Benign and malignant intra-axial tumors of the MESENCEPHALON; PONS; or MEDULLA OBLONGATA of the BRAIN STEM. Primary and metastatic neoplasms may occur in this location. Clinical features include ATAXIA, cranial neuropathies (see CRANIAL NERVE DISEASES), NAUSEA, hemiparesis (see HEMIPLEGIA), and quadriparesis. Primary brain stem neoplasms are more frequent in children. Histologic subtypes include GLIOMA; HEMANGIOBLASTOMA; GANGLIOGLIOMA; and EPENDYMOMA.
The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Electrical waves in the CEREBRAL CORTEX generated by BRAIN STEM structures in response to auditory click stimuli. These are found to be abnormal in many patients with CEREBELLOPONTINE ANGLE lesions, MULTIPLE SCLEROSIS, or other DEMYELINATING DISEASES.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Infarctions that occur in the BRAIN STEM which is comprised of the MIDBRAIN; PONS; and MEDULLA OBLONGATA. There are several named syndromes characterized by their distinctive clinical manifestations and specific sites of ischemic injury.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Parts of plants that usually grow vertically upwards towards the light and support the leaves, buds, and reproductive structures. (From Concise Dictionary of Biology, 1990)
Progenitor cells from which all blood cells derive.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Cells with high proliferative and self renewal capacities derived from adults.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
The front part of the hindbrain (RHOMBENCEPHALON) that lies between the MEDULLA and the midbrain (MESENCEPHALON) ventral to the cerebellum. It is composed of two parts, the dorsal and the ventral. The pons serves as a relay station for neural pathways between the CEREBELLUM to the CEREBRUM.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
A variant of ADENOMATOUS POLYPOSIS COLI caused by mutation in the APC gene (GENES, APC) on CHROMOSOME 5. It is characterized by not only the presence of multiple colonic polyposis but also extracolonic ADENOMATOUS POLYPS in the UPPER GASTROINTESTINAL TRACT; the EYE; the SKIN; the SKULL; and the FACIAL BONES; as well as malignancy in organs other than the GI tract.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE), found in Australia and New Guinea. It causes a fulminating viremia resembling Japanese encephalitis (ENCEPHALITIS, JAPANESE).
A TEXTILE fiber obtained from the pappus (outside the SEEDS) of cotton plant (GOSSYPIUM). Inhalation of cotton fiber dust over a prolonged period can result in BYSSINOSIS.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Intracranial tumors originating in the region of the brain inferior to the tentorium cerebelli, which contains the cerebellum, fourth ventricle, cerebellopontine angle, brain stem, and related structures. Primary tumors of this region are more frequent in children, and may present with ATAXIA; CRANIAL NERVE DISEASES; vomiting; HEADACHE; HYDROCEPHALUS; or other signs of neurologic dysfunction. Relatively frequent histologic subtypes include TERATOMA; MEDULLOBLASTOMA; GLIOBLASTOMA; ASTROCYTOMA; EPENDYMOMA; CRANIOPHARYNGIOMA; and choroid plexus papilloma (PAPILLOMA, CHOROID PLEXUS).
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
Neoplasms composed of neuroepithelial cells, which have the capacity to differentiate into NEURONS, oligodendrocytes, and ASTROCYTES. The majority of craniospinal tumors are of neuroepithelial origin. (From Dev Biol 1998 Aug 1;200(1):1-5)
Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
A general term collectively applied to tumors associated with the APUD CELLS series, irrespective of their specific identification.
A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.
The ginseng plant family of the order Apiales, subclass Rosidae, class Magnoliopsida. Leaves are generally alternate, large, and compound. Flowers are five-parted and arranged in compound flat-topped umbels. The fruit is a berry or (rarely) a drupe (a one-seeded fruit). It is well known for plant preparations used as adaptogens (immune support and anti-fatigue).
Tuberculosis resistant to chemotherapy with two or more ANTITUBERCULAR AGENTS, including at least ISONIAZID and RIFAMPICIN. The problem of resistance is particularly troublesome in tuberculous OPPORTUNISTIC INFECTIONS associated with HIV INFECTIONS. It requires the use of second line drugs which are more toxic than the first line regimens. TB with isolates that have developed further resistance to at least three of the six classes of second line drugs is defined as EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
Societies whose membership is limited to physicians.
An examination, review and verification of all financial accounts.
Reorganization of the hospital corporate structure.
Management control systems for structuring health care delivery strategies around case types, as in DRGs, or specific clinical services.
Professional society representing the field of medicine.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)
Disciplines concerned with the interrelationships of individuals in a social environment including social organizations and institutions. Includes Sociology and Anthropology.
Social media model for enabling public involvement and recruitment in participation. Use of social media to collect feedback and recruit volunteer subjects.
Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Mapping of the KARYOTYPE of a cell.
A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)
Established cell cultures that have the potential to propagate indefinitely.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.

Selective innervation of retinorecipient brainstem nuclei by retinal ganglion cell axons regenerating through peripheral nerve grafts in adult rats. (1/149)

The pattern of axonal regeneration, specificity of reinnervation, and terminal arborization in the brainstem by axotomized retinal ganglion cell axons was studied in rats with peripheral nerve grafts linking the retina with ipsilateral regions of the brainstem, including dorsal and lateral aspects of the diencephalon and lateral aspect of the superior colliculus. Four to 13 months later, regenerated retinal projections were traced using intraocular injection of cholera toxin B subunit. In approximately one-third of the animals, regenerated retinal axons extended into the brainstem for distances of up to 6 mm. Although axons followed different patterns of ingrowth depending on their site of entry to the brainstem, within the pretectum, they innervated preferentially the nucleus of the optic tract and the olivary pretectal nucleus in which they formed two types of terminal arbors. Within the superior colliculus, axons extended laterally and formed a different terminal arbor type within the stratum griseum superficiale. In the remaining two-thirds of the animals, retinal fibers formed a neuroma-like structure at the site of entry into the brainstem, or a few fibers extended for very short distances within the neighboring neuropil. These experiments suggest that regenerated retinal axons are capable of a highly selective reinnervation pattern within adult denervated retinorecipient nuclei in which they form well defined terminal arbors that may persist for long periods of time. In addition, these studies provide the anatomical correlate for our previous functional study on the re-establishment of the pupillary light reflex in this experimental paradigm.  (+info)

Radiation therapy and high-dose tamoxifen in the treatment of patients with diffuse brainstem gliomas: results of a Brazilian cooperative study. Brainstem Glioma Cooperative Group. (2/149)

PURPOSE: The efficacy of radiation therapy (RT) combined with tamoxifen (TX) was tested in patients diagnosed with diffuse brainstem gliomas in a multicenter trial. PATIENTS AND METHODS: TX was administered orally (maintenance dose: 200 mg/m(2) per day) along with conventional local RT and then continued for 52 additional weeks. Survival, tumoral radiologic response, and toxicity were evaluated. Compliance was assessed using pharmacokinetic measurements. RESULTS: Of 29 patients, 27 completed RT (median dose, 54 Gy). Of 22 assessable patients, 11 (50%) had an objective radiologic response. The mean TX steady-state serum level was 2.44 micromol/L +/- 1.02 micromol/L. Only three patients completed the entire course of treatment without tumoral progression or significant toxicity. Common side effects included nausea and vomiting. Hepatotoxicity (five patients), neurotoxicity (two patients), venous thrombosis (one patient), bilateral ovarian cysts (two patients), and transient neutropenia (one patient) were also observed. Median survival was 10.3 months. Only four patients remain alive without tumoral progression. The 1-year survival rate (mean +/- SD) was 37.0% +/- 9.5%. CONCLUSION: This treatment combination produced no significant change in the overall poor prognosis of these patients. Most tumors responded initially to treatment but recurred as the study progressed. A minority of patients seemed to benefit from the extended use of TX. Generally, treatment was well tolerated, with good patient compliance, but we recommend continuous close monitoring for side effects. Based on our poor results, we recommend that alternative treatments be tested in patients with this type of tumor.  (+info)

Intramedullar stimulation of the facial and hypoglossal nerves: estimation of the stimulated site. (3/149)

AIM: To determine the stimulation site of both facial and hypoglossal nerves after transcranial magnetic stimulation. METHODS: After surgical exposure of the brainstem in 22 patients with intrinsic pontine (n=9) or medullary (n=13) tumors, the facial colliculus and the hypoglossal triangle were electrically stimulated. The EMG responses were recorded with flexible wire electrodes from the orbicularis oculi/orbicularis oris muscles, and genioglossal muscles. Patients had no preoperative deficit of the nerves. RESULTS: The EMG mean latencies of the unaffected facial nerve were 5.2+/-0.6 ms for the orbicularis oculi, and 5.2+/-0.5 ms for the orbicularis oris muscle. After the stimulation of 18 possibly affected facial nerves, the EMG mean latencies were 5.3+/-0.3 ms for the orbicularis oculi (p=0.539, unpaired Student's t-test), and 5.4+/-0.2 ms for the orbicularis oris (p=0.122). The EMG mean latency of the unaffected hypoglossal nerve was 4.1+/-0.6 ms for the genioglossal muscle. After the stimulation of 26 possibly affected hypoglossal nerves, the EMG mean latency for the genioglossal muscle was 5.3+/-0.3 ms. There was a significant difference (p<0.001) in latency for genioglossal EMG responses between the patients with pontine and those with medullary tumors. CONCLUSION: Shorter EMG mean latencies of unaffected facial nerves obtained after direct stimulation of the facial colliculi confirm that magnetic stimulation is most likely to occur closer to the nerve's exit from the brainstem than to its entrance into the internal auditory meatus. The hypoglossal nerve seems to have the site of excitation at the axon hillock of the hypoglossal motor neurons.  (+info)

Intra-axial tumors of the medullocervical junction: diagnosis and microsurgical treatment. (4/149)

OBJECTIVE: To describe the clinical features, operative methods and postoperative management of the intra-axial tumors of medullocervical junction, and to make differential diagnosis for different subtypes. METHODS: Fifteen patients with intra-axial tumors of medullocervical junction were treated from August 1988 to June 1997. The diagnoses were confirmed by MRI and histological examinations. The tumors were divided into two subtypes according to the clinical features and the main body of the tumor. The distinctive points of the two subtypes and the appropriate surgical methods of different pathological type tumors were expounded. RESULTS: Tumors were totally removed in 10 patients and subtotally in 5. There was no death caused by operation. Postoperative complications included respiratory disturbance in six cases, upper digestive tract bleeding in one, depressed cough reflex in two, most of which recovered after proper treatment. On discharge, the nervous system status was improved in 11 cases, stable in 2 and worsened in 2. CONCLUSIONS: The intra-axial tumors of medullocervical junction can be divided into cervicomedullary and medullocervical subtypes. The MRI examination is decisive in the distinction of the diagnosis, and is important in the determination of the nature of the medullar cystic lesions and the guidance of the resection of tumor extent. The cervicomedullary tumors are more amenable to an aggressive surgical treatment, during which the surgeon should remove the tumors first in the cervical spinal cord area, then in the medullar area with the tumor resection expanding rostrally. It can make the operation safer to remove the tumors using appropriate techniques varied with pathological types of the tumors. Managing postoperative respiratory disturbances without delay is one of the important points in improving the therapeutic effect.  (+info)

Paroxysmal alternating skew deviation and nystagmus after partial destruction of the uvula. (5/149)

A patient with suspected brain stem glioma involving the area of the left vestibular nuclei and cerebellar peduncle, developed paroxysmal alternating skew deviation and direction changing nystagmus after biopsy of the inferior cerebellar vermis resulting in destruction of the uvula. Between attacks she had right over left skew deviation with asymptomatic right beating horizontal nystagmus. Slow phases of the resting nystagmus showed increasing velocity, similar to congenital nystagmus. At intervals of 40-50 seconds, paroxysmal reversal of her skew deviation occurred, accompanied by violent left beating horizontal torsional nystagmus lasting 10-12 seconds and causing severe oscillopsia. It is proposed that this complex paroxysmal eye movement disorder results from (1) a lesion in the left vestibular nuclei causing right over left skew and right beating resting nystagmus and (2) a disruption of cerebellar inhibition of vestibular nuclei, causing alternating activity in the vestibular system with intermittent reversal of the skew deviation and paroxysmal nystagmus towards the side of the lesion.  (+info)

Perfusion-sensitive MR imaging of gliomas: comparison between gradient-echo and spin-echo echo-planar imaging techniques. (6/149)

BACKGROUND AND PURPOSE: The different sensitivities to vessel size of gradient-echo echo-planar imaging (GE-EPI) and spin-echo EPI (SE-EPI) might indicate the relative cerebral blood volumes (rCBVs) of different tumor sizes. The techniques of GE-EPI and SE-EPI were compared for detecting low- versus high-grade gliomas. METHODS: Six patients with low-grade gliomas and 19 patients with high-grade gliomas underwent two perfusion-sensitive MR procedures, one produced by a GE- and the other by an SE-EPI technique. Maximum rCBV ratios normalized with rCBV of contralateral white matter were calculated for evaluation. P <.05 was considered statistically significant. RESULTS: Maximum rCBV ratios of high-grade gliomas obtained with the GE-EPI technique (mean, 5.0 +/- 2.9) were significantly higher than those obtained with the SE-EPI technique (mean, 2.9 +/- 2.3) (P =.02). Maximum rCBV ratios of low-grade gliomas obtained with the GE-EPI technique (mean, 1.2 +/- 0.7) were almost equal to those obtained with the SE-EPI technique (mean, 1.2 +/- 0.6), and there was no significant difference (P =.66). The difference in the maximum rCBV ratios between the low- and high-grade gliomas reached significance when obtained with the GE-EPI technique (P =.01). CONCLUSION: The GE-EPI technique seems more useful for detecting low- versus high-grade gliomas than the SE-EPI technique.  (+info)

The causes of dysphagia in carcinoma of the lung. (7/149)

Dysphagia occurs in only a small percentage of patients with lung cancer, but the frequency of this cancer means that large numbers are affected. Non-quantitative analysis of a large Scottish series of lung cancer cases indicates the following eight broad categories of dysphagia according to underlying mechanisms: mediastinal disease; cervical lymphadenopathy; brainstem lesions; gastrointestinal tract metastases; associated systemic disorders; second primaries; oropharyngeal and oesophageal infections; and radiation-induced oesophageal toxicity.  (+info)

Brainstem gliomas in adults: prognostic factors and classification. (8/149)

In contrast to childhood brainstem gliomas, adult brainstem gliomas are rare and poorly understood. The charts of 48 adults suffering from brainstem glioma were reviewed in order to determine prognostic factors, evaluate the effect of treatment and propose a classification of these tumours. Mean age at onset was 34 years (range 16-70 years). The main presenting symptoms were gait disturbance (61%), headache (44%), weakness of the limbs (42%) and diplopia (40%). Four patterns were identified on MRI, representing non-enhancing, diffusely infiltrative tumours (50%), contrast-enhancing localized masses (31%), isolated tectal tumours (8%) and other patterns (11%). Treatment consisted of partial resection (8%), radiotherapy (94%) and chemotherapy (56%). Overall median survival was 5.4 years. On univariate analysis, the following favourable prognostic factors were identified (P< 0.01): age of onset <40 years, duration of symptoms before diagnosis >3 months, Karnofski performance status >70, low-grade histology, absence of contrast enhancement and 'necrosis' on MRI. On multivariate analysis, the duration of symptoms, the appearance of 'necrosis' on MRI and the histological grade of the tumour remained significant and independent prognostic factors (P< 0.05). Eighty-five percent of the tumours could be classified into one of the following three groups on the basis of clinical, radiological and histological features. (i) Diffuse intrinsic low-grade gliomas (46%) usually occurred in young adults with a long clinical history before diagnosis and a diffusely enlarged brainstem on MRI that did not show contrast enhancement. These patients were improved by radiotherapy in 62% of cases and had a long survival time (median 7.3 years). Anaplastic transformation (appearance of contrast enhancement, 27%) and relentless growth without other changes (23%) were the main causes of death. (ii) Malignant gliomas (31%) occurred in elderly patients with a short clinical history. Contrast enhancement and necrosis were the rule on MRI. These tumours were highly resistant to treatment and the patients had a median survival time of 11.2 months. (iii) Focal tectal gliomas (8%) occurred in young patients and were often revealed by isolated hydrocephalus. The course was indolent and the projected median survival period exceeded 10 years. In conclusion, adult brainstem gliomas are different from the childhood forms and resemble supratentorial gliomas in adults. Low-grade tumours have a clinicoradiological pattern that is so characteristic that the need for a potentially harmful biopsy is debatable. The optimum timing of treatment for supratentorial low-grade tumours remains unclear. In high-grade gliomas, the prognosis remains extremely poor despite aggressive treatment with radiotherapy and chemotherapy.  (+info)

TY - JOUR. T1 - Proceedings of the diffuse intrinsic pontine glioma (DIPG) Toronto Think Tank. T2 - Advancing basic and translational research and cooperation in DIPG. AU - Bartels, Ute. AU - Hawkins, Cynthia. AU - Vézina, Gilbert. AU - Kun, Larry. AU - Souweidane, Mark. AU - Bouffet, Eric. PY - 2011/10/1. Y1 - 2011/10/1. N2 - Diffuse intrinsic pontine glioma (DIPG) nearly exclusively affects children. The prognosis of DIPGs has remained grim despite more than three decades of clinical research and numerous clinical trials. More than 90% of the children with DIPG will succumb within 2 years of diagnosis. The tumors incidence is still undefined, but data suggest 100-150 affected children annually in the US. The single proven effective treatment modality in DIPG remains radiation therapy. For the majority of patients however this treatment is only of transient effectiveness. Recent breakthroughs in the understanding of the molecular biology of DIPG have raised new hope and opened new avenues for ...
TY - JOUR. T1 - Liquid biopsy for diffuse intrinsic pontine glioma. T2 - An update. AU - Lu, Victor M.. AU - Power, Erica A.. AU - Zhang, Liang. AU - Daniels, David J.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Diffuse intrinsic pontine glioma (DIPG), otherwise known as diffuse midline glioma with H3K27M mutation, is a devastating brainstem glioma without a cure. Efforts are currently underway to better optimize molecular diagnoses through biological sampling, which today remains largely limited to surgical biopsy sampling. Surgical intervention is not without its risks, and therefore a preference remains for a less invasive modality that can provide biological information about the tumor. There is emerging evidence to suggest that a liquid biopsy, targeting biofluids such as CSF and blood plasma, presents an attractive alternative for brain tumors in general. In this update, the authors provide a summary of the progress made to date regarding the use of liquid biopsy to diagnose and monitor DIPG, and ...
Due to the poor prognosis of diffuse intrinsic pontine gliomas, the limited therapy options, the relevant portion of EGFR expression and the unexpected good response to the therapy with OSAG 101 in the phase II study, a phase III study was planned in newly diagnosed diffuse intrinsic pontine gliomas in children and adolescents. A phase II study in patients of recurrence/resistance high grade glioma in childhood or adolescence showed that, in particular, a part of the intrinsic pontine glioma response to the monotherapy with OSAG 101 resulting in a reduction in the size of the tumour or stabilisation in the growth of the tumour. Together with clinical improvement, stabilisation lasted markedly over 6 months in two thirds of the patients. The current phase III study was scheduled to provide evidence of the effectiveness in the case of newly diagnosed intrinsic pontine glioma. In this study, OSAG 101 will be given concomitantly to the only standard therapy for this kind of tumour, i.e. the ...
TY - JOUR. T1 - Radiosensitization by histone H3 demethylase inhibition in diffuse intrinsic pontine glioma. AU - Katagi, Hiroaki. AU - Louis, Nundia. AU - Unruh, Dusten. AU - Sasaki, Takahiro. AU - He, Xingyao. AU - Zhang, Ali. AU - Ma, Quanhong. AU - Piunti, Andrea. AU - Shimazu, Yosuke. AU - Lamano, Jonathan B.. AU - Carcaboso, Angel M.. AU - Tian, Xiao. AU - Seluanov, Andrei. AU - Gorbunova, Vera. AU - Laurie, Kathryn L.. AU - Kondo, Akihide. AU - Wadhwani, Nitin R.. AU - Lulla, Rishi. AU - Goldman, Stewart. AU - Venneti, Sriram. AU - Becher, Oren J.. AU - Zou, Lihua. AU - Shilatifard, Ali. AU - Hashizume, Rintaro. PY - 2019/9/15. Y1 - 2019/9/15. N2 - Purpose: Radiotherapy (RT) has long been and remains the only treatment option for diffuse intrinsic pontine glioma (DIPG). However, all patients show evidence of disease progression within months of completing RT. No further clinical benefit has been achieved using alternative radiation strategies. Here, we tested the hypothesis that histone ...
TY - THES. T1 - Diffuse Intrinsic Pontine Glioma. T2 - A multi-facetted and global view. AU - Veldhuijzen van Zanten, SEM. PY - 2017. Y1 - 2017. KW - Diffuse intrinsic pontine glioma. M3 - Research VU University Amsterdam, graduation VU University Amsterdam. ER - ...
For 45 years, clinicians around the nation have been offering the parents of pediatric patients diagnosed with diffuse intrinsic pontine glioma (DIPG) the same grim prognosis. Now, researchers at Children’s National are seizing the opportunity to change that narrative, by exploring the genetic mutations associated with this disease to unlock the possibility of new therapies.
OBJECTIVE In this clinical trial report, the authors analyze safety and infusion distribution of IL13-Pseudomonas exotoxin, an antitumor chimeric molecule, administered via intratumoral convection enhanced delivery (CED) in pediatric patients with diffuse intrinsic pontine glioma (DIPG). METHODS Thi …
Diffuse intrinsic pontine glioma (DIPG) is the deadliest central nervous system tumor in children. The survival of affected children has remained poor despite treatment with radiation therapy (RT) wit
We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of ,1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumors. Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct. Uncommon pathway dysregulation is seen in small subsets of tumors, further defining the molecular diversity of the disease, opening up avenues for biological study and providing a basis for functionally defined future treatment stratification ...
This phase I trial studies the side effects and best dose of panobinostat in treating younger patients with diffuse intrinsic pontine glioma that is growing,
TY - JOUR. T1 - Overcoming the Blood-Brain Barrier to Target Diffuse Intrinsic Pontine Glioma. T2 - Whats New?. AU - Lu, Victor M.. AU - Power, Erica A.. AU - Zhang, Liang. AU - Daniels, David J.. PY - 2020. Y1 - 2020. UR - http://www.scopus.com/inward/record.url?scp=85085917004&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85085917004&partnerID=8YFLogxK. U2 - 10.1016/j.wneu.2020.05.008. DO - 10.1016/j.wneu.2020.05.008. M3 - Article. C2 - 32389870. AN - SCOPUS:85085917004. JO - World Neurosurgery. JF - World Neurosurgery. SN - 1878-8750. ER - ...
Brain Stem Glioma Treatment, Brain Stem Glioma Treatment India, Brain Stem Glioma Treatment Cost In India Info On Cost Brain Stem Glioma Treatment Mumbai Delhi Bangalore India, Brain Stem Glioma Treatment Hospitals Center India, Brain Stem Glioma Treatment Doctors Surgeon India
Full Title A Phase I Study of Convection-Enhanced Delivery of 124I-Omburtomab for Patients with Non-Progressive Diffuse Pontine Gliomas Previously Treated with External Beam Radiation Therapy Purpose Diffuse intrinsic pontine glioma (DIPG, also known as brain stem glioma) is a cancer of the brain stem, most often in children, which is very difficult to treat successfully. Radiation treatment is usually the first form of therapy, followed by chemotherapy. While patients may respond to therapy initially, the tumor almost always returns.
Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study. J Clin Oncol. 2010 Jun 20; 28(18):3069-75 ...
Inoperable brainstem gliomas (BSG) are among the most difficult to treat malignancies. In the intent-to-treat (ITT) population of the BT-11 study for BSG, forty patients (median age 11.2 years old) were enrolled. Antineoplastons A10 and AS2-1 (ANP) were administered intravenously daily. The median daily dose of A10 was 8.70 g/kg/day and AS2-1 was 0.32 g/kg/day. Efficacy analyses were conducted in two subgroups: recurrent pediatric diffuse intrinsic pontine glioma (RPDIPG, N = 17) and non-diffuse intrinsic pontine glioma (NDIPG, N = 11). This paper reports the results of the study of the efficacy and safety of ANP in patients with NDIPG. The results in the RPDIPG group were reported before; complete response (CR) was 6%, partial response (PR) 23.5%, and stable disease (SD) 17.6%. One year overall survival (OS) was 29.4%, 2 years 11.8%, and 5, 10, and 15 years 6%. In the NDIPG group, there were 36% CR and 27.5% SD. OS at 1, 5, 10, and 15 years was 82%, 73%, 62%, and 50% correspondingly. There
The following data/materials will be collected:. Clinical: Demographic data, date of diagnosis, signs and symptoms at diagnosis, laboratory data, detailed treatment data (e.g. types and dates of surgeries (if any), chemotherapy, radiotherapy), best response to treatment, dates of progression, types of progression (local or metastatic), and follow-up data.. Imaging: All radiographic imaging obtained since diagnosis will be requested at the time of study entry.. Pathology Central Review: If glass slides (stained or unstained) or paraffin blocks of tumor tissue (from biopsy or autopsy) are available, they will be requested at the time of registry entry but are not mandatory for enrollment.. Bioinfomatics repository: Collection of existing molecular and/or genomic data or analysis that has been performed as well as prospective analysis of tissue from the registry will be submitted to a central bioinformatics repository and may be linked to clinical data housed in the DIPG registry.. Tissue ...
Comprehensive reviews of DIPG-specific clinical trials have previously been published, analyzing a total of 55 DIPG-specific trials covering the period from 1984 to March 2011 [10,11]. Despite the large number of clinical trials, no clear improvement in either the quality of life or length of survival has been demonstrated, and most studies are, in hindsight, complicated by the wide variance in the selection criteria and absence of accompanying genomic and molecular data. Additionally, a systematic clinical review from the Netherlands has emphasized the necessity of cross-national cooperation to prevent potential epidemiological bias [5]. The pharmacologic agents investigated to date are largely based on therapies proven to convey survival benefit in the treatment of adult gliomas. The only agents with activity against DIPG genomic targets which have been investigated are anti-EGFR tyrosine kinase inhibitors, and results to date are inconclusive, possibly owing to varied selection criteria. One ...
Glioblastoma multiforme (GBM) and diffuse intrinsic pontine glioma (DIPG) are aggressive subtypes of brain tumors that both have a very poor prognosis and are almost always lethal. Two new studies in Nature and this journal today identify the same recurrent mutations in H3F3A in pediatric cases of glioblastoma multiforme and diffuse intrinsic pontine glioma. These are the first reports of human disease associated with mutations in histones, which play an extraordinarily important and conserved role in chromatin structure and gene regulation. With the recent spate of papers reporting somatic mutations in chromatin remodelers in various types of cancer (examples from this journal alone include the histone H3K27 demethylase UTX, transitional cell carcinoma of the bladder, histone methyltransferase EZH2 in follicular and diffuse large B-cell lymphoma and myeloid disorders, DNMT3A in AML, ARID2 in hepatocellular carcinoma, MLL2 in DLBCL, and ARID1a in gastric cancer) it is clear that targeting the ...
ISI Document Delivery No.: AG4XE Times Cited: 1 Cited Reference Count: 20 Taylor, Kathryn R. Mackay, Alan Truffaux, Nathalene Butterfield, Yaron S. Morozova, Olena Philippe, Cathy Castel, David Grasso, Catherine S. Vinci, Maria Carvalho, Diana Carcaboso, Angel M. de Torres, Carmen Cruz, Ofelia Mora, Jaume Entz-Werle, Natacha Ingram, Wendy J. Monje, Michelle Hargrave, Darren Bullock, Alex N. Puget, Stephanie Yip, Stephen Jones, Chris Grill, Jacques Cancer Research UK Genomics Initiative [A14078]; Stavros Niarchos Foundation; Abbies Army; Lyla Nsouli Foundation; Royal Marsden Hospital Childrens Department Fund; Fondo Alicia Pueyo; National Institutes of Neurological Disease and Stroke (NINDS) [K08NS070926]; Alexs Lemonade Stand Foundation; McKenna Claire Foundation; charity lEtoile de Martin; Agence National de la Recherche; Enfants et Sante; Fundacion Cientifica de la Asociacion Espanola Contra el Cancer; Childrens Health Foundation Queensland; Brainchild Foundation; Canada Foundation for ...
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About 15 months ago I went on Facebook to see if a friend of mine, who lives in Raleigh, had a Facebook page. When I typed in her name, I was taken to a link to a prayer group for Ella Newmiller. Now I knew that Ella was my friends daughter (we do exchange holiday cards) and quite frankly, I was in shock. Ella, now 6, was diagnosed at the end of April 2008 with a DIPG (diffuse intrinsic pontine glioma), or brain-stem tumor. DIPG is a rare form of cancer (approximately 200 children per year are diagnosed with the disease), which sits in the brain stem, or pons region of the brain. Essentially every major function within the human body (with the exception of smell) must pass through the pons (e.g. consciousness, sight, the ability to swallow etc). The trouble with DIPG is that it is inoperable and for the most part, untreatable. The diagnosis remains grim. Approximately 90% of children diagnosed with the disease do not live longer than 18 months ...
As a researcher of The Morgan Adams Foundation Pediatric Brain Tumor Research Program at Childrens Hospital Colorado, she is working to find a cure for DIPG - diffuse intrinsic pontine glioma - which is 100% fatal. I am currently working on identifying the genes that cause DIPG and to identify gene pathways that make the DIPG tumor aggressive after relapse from radiation treatment.. The typical treatment for DIPG patients is radiation, the only standard therapy so far. But, the tumor comes back after radiation, growing even more aggressively than the original tumor and becomes resistant to radiation therapy. At that point, there are no treatment options and parents are often told to take their child home to spend the limited time they have left away from the hospital.. DIPG affects children almost exclusively. Approximately 200-400 children in the United States are diagnosed with DIPG each year. Since very little is known about DIPG tumor biology, I want to understand the biology of this ...
With the lag time between presentation at a meeting and publications often times things can just slip under the radar. For me, this was certainly true of this American Association for Cancer Research abstract presented last year in Philadelphia- High-level activation of the Notch pathway in diffuse intrinsic pontine glioma. The title doesnt immediately excite me. However, packed in this short abstract is a number of significant advancements in DIPG research. ...
Michael Mosier Defeat DIPG Foundation and The ChadTough Foundation are funding ten new Diffuse Intrinsic Pontine Glioma (DIPG)-specific research projects totaling more than $2.8 million over the next three years (2020-22). Two of the new grants will be ma ...
Brain tumors are the most common solid cancer in children. Up to 12% of pediatric brain tumors are high-grade gliomas (HGGs). Typical management involves surgical removal, followed by chemotherapy and radiation treatment. However, despite ongoing research and a variety of treatment approaches, the five- year survival rate for children with high-grade glioma is only 20%, with the majority of children succumbing to their disease.. Approximately 15% of pediatric brain tumors arise in the brainstem, of which 80% are a subtype known as diffuse intrinsic pontine glioma (DIPG). DIPG is an infiltrative, high-grade tumor, and has the highest mortality rate of all pediatric solid tumors. DIPG affects young children with onset between 6 and 9 years of age. Radiation therapy is the standard treatment, temporarily decreasing symptoms, yet DIPG continues to exhibit the highest mortality rate of all pediatric brain tumors with median survival less than 12 months and 5-year survival less than 5%. Despite almost ...
Brain stem gliomas are tumors found in the brain stem.. The brainstem is a very delicate location where many pathways from the brain to the spinal cord travel. Tumors in this location can be very challenging to treat. The majority of the tumors are located in the middle of the brainstem and cannot be surgically removed. A minority of brainstem tumors are more favorably located and can be treated with surgery.. Brain stem gliomas occur almost exclusively in children; the group most often affected is the school-age child. The child usually does not have increased intracranial pressure, but may have problems with double vision, movement of the face or one side of the body, or difficulty with walking and coordination. ...
Positron emission tomography (PET) scanning with [18 F]fluorodeoxyglucose (18 F-FDG) is a useful diagnostic and prediction tool in brain tumors, but its value in childhood diffuse intrinsic pontine glioma (DIPG) is still unclear. For interpretation of 18 F-FDG PET results in DIPG, uptake values of the normal pons of children of increasing ages are mandatory. The aim of this study was to determine 18 F-FDG standard uptake value ratios (SUVr) of the normal pons and to compare these to those of DIPG. We studied 36 subjects with a normal, non-affected pons (aged 5 to 23 years) and 6 patients with DIPG (aged 4 to 17 years) who underwent 18 F-FDG PET scanning. Magnetic resonance imaging (MRI) was co-registered to define the regions of interest. SUVr and SUVrmax for the pons/cerebellum (SUVrp/c) and the pons/occipital lobe (SUVrp/o) were calculated. Independent-samples t tests and Mann-Whitney U tests were used to compare the mean SUVr and Pearsons test for correlations. For the normal pons, mean SUVrp/c and
Researchers at the University of Michigan have secured a federal grant for research into a potential treatment for Diffuse Intrinsic Pontine Glioma (DIPG).
Gupta N, Goumnerova LC, Manley P, Chi SN, Neuberg D, Puligandla M, Fangusaro J, Goldman S, Tomita T, Alden T, DiPatri A, Rubin JB, Gauvain K, Limbrick D, Leonard J, Geyer JR, Leary S, Browd S, Wang Z, Sood S, Bendel A, Nagib M, Gardner S, Karajannis MA, Harter D, Ayyanar K, Gump W, Bowers DC, Weprin B, MacDonald TJ, Aguilera D, Brahma B, Robison NJ, Kiehna E, Krieger M, Sandler E, Aldana P, Khatib Z, Ragheb J, Bhatia S, Mueller S, Banerjee A, Bredlau AL, Gururangan S, Fuchs H, Cohen KJ, Jallo G, Dorris K, Handler M, Comito M, Dias M, Nazemi K, Baird L, Murray J, Lindeman N, Hornick JL, Malkin H, Sinai C, Greenspan L, Wright KD, Prados M, Bandopadhayay P, Ligon KL, Kieran MW. Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma. Neuro Oncol. 2018 10 09; 20(11):1547-1555 ...
The outcome for children with high-grade gliomas (HGG) remains dismal, with a 2-year survival rate of only 10% to 30%. Diffuse intrinsic pontine glioma (DIPG) comprise a subset of HGG that arise in the brainstem almost exclusively in children. Genome-wide analyses of copy number imbalances previously showed that platelet-derived growth factor receptor alpha (PDGFRA) is the most frequent target of focal amplification in pediatric HGGs, including DIPGs. To determine whether PDGFRA is also targeted by more subtle mutations missed by copy number analysis, we sequenced all PDGFRA coding exons from a cohort of pediatric HGGs. Somatic-activating mutations were identified in 14.4% (13 of 90) of nonbrainstem pediatric HGGs and 4.7% (2 of 43) of DIPGs, including missense mutations and in-frame deletions and insertions not previously described. Forty percent of tumors with mutation showed concurrent amplification, whereas 60% carried heterozygous mutations. Six different mutations impacting different ...
Introduction Diffuse intrinsic pontine glioma (DIPG) is a malignant pediatric brain tumor associated with dismal outcome. Recent high-throughput molecular studies have shown a high frequency of mutations in histone-encoding genes (H3F3A and HIST1B) and distinctive epigenetic alterations in these tumors. Epigenetic alterations described in DIPG include global DNA hypomethylation. In addition to the generally repressive methylcytosine DNA alteration, 5-hydroxymethylation of cytosine (5hmC) is recognized as an epigenetic mark associated with active chromatin. We hypothesized that in addition to alterations in DNA methylation, that there would be changes in 5hmC. To test this hypothesis, we performed immunohistochemical studies to compare epigenetic alterations in DIPG to extrapontine adult and pediatric glioblastoma (GBM) and normal brain. A total of 124 tumors were scored for histone 3 lysine 27 trimethylation (H3K27me3) and histone 3 lysine 9 trimethylation (H3K9me3) and 104 for 5hmC
Our young friend Cooper knew research was being done on rare types of kids brain tumors. He knew that research took money. So when doctors explained last April that his hope for remission was gone, the bright 12-year-old had an idea: he would use his life savings to find a cure. If only it were that simple. If only the dollars Cooper had saved for college could have made that happen. If only diffuse intrinsic pontine glioma, or DIPG, werent the deadly pediatric brain cancer it is. If only the answers had been found before it claimed his life.. After Cooper passed, Sujatha Venkataraman, PhD - one of the researchers working closely with The Morgan Adams Foundation (MAF) - told his parents that targeting DIPG is her only mission and focus in life. I lost my own small son Rishi to cancer, Venkataraman reflects. Kids should not go through these sufferings. DIPG is under-researched and it is always fatal. We are working hard to find a way to improve outcomes for these children. Childhood ...
Our young friend Cooper knew research was being done on rare types of kids brain tumors. He knew that research took money. So when doctors explained last April that his hope for remission was gone, the bright 12-year-old had an idea: he would use his life savings to find a cure. If only it were that simple. If only the dollars Cooper had saved for college could have made that happen. If only diffuse intrinsic pontine glioma, or DIPG, werent the deadly pediatric brain cancer it is. If only the answers had been found before it claimed his life.. After Cooper passed, Sujatha Venkataraman, PhD - one of the researchers working closely with The Morgan Adams Foundation (MAF) - told his parents that targeting DIPG is her only mission and focus in life. I lost my own small son Rishi to cancer, Venkataraman reflects. Kids should not go through these sufferings. DIPG is under-researched and it is always fatal. We are working hard to find a way to improve outcomes for these children. Childhood ...
Diffuse Intrinsic Pontine Glioma (DIPG) is a childhood brain cancer without cure. Children with this cancer die within a year of diagnosis. My research focuses on an innovative approach to find a cure for DIPG. This is currently the only research on DIPG in Australia where the tumor cells are collected from patients, grown and treated with drugs in search for an effective therapy. It is like finding a needle in a haystack. For some it is a hopeless end but for me it is an endless hope.. ...
Doctors told Giannina and Michael Gioe of Scranton that their daughter, Ava, had a rare brain stem tumor and there was nothing that could be done to save her life.. Its a death sentence, Mrs. Gioe said of the diagnosis, diffuse intrinsic pontine glioma, that claimed Avas life at age 5 on July 20, 2012, after a 20-month battle.. That there was no hope given and so little known about the DIPG tumor was unacceptable to the couple, who established A Miracle For Ava Pediatric Brain Tumor Foundation to raise awareness and fund research into the cause and treatment of the illness.. The foundation held its inaugural Golden Gala on Saturday at Genetti Manor in Dickson City. Organizers were hoping to raise $5,000 at the event.. The DIPG tumor, which causes children to lose their ability to speak, eat, walk and swallow, is so rare that there are only 150 to 200 cases diagnosed annually in the United States, they said.. Surgery is not an option because of the way the tumor entangles itself in the brain ...
The median overall survival for children with diffuse intrinsic pontine glioma (DIPG) is less than one year. The majority of diffuse midline gliomas, including more than 70% of DIPGs, harbor an amino acid substitution from lysine (K) to methionine (M) at position 27 of histone 3 variant 3 (H3.3). From a CD8+ T cell clone established by stimulation of HLA-A2+ CD8+ T cells with synthetic peptide encompassing the H3.3K27M mutation, complementary DNA for T cell receptor (TCR) α- and β-chains were cloned into a retroviral vector. TCR-transduced HLA-A2+ T cells efficiently killed HLA-A2+H3.3K27M+ glioma cells in an antigen- and HLA-specific manner. Adoptive transfer of TCR-transduced T cells significantly suppressed the progression of glioma xenografts in mice. Alanine-scanning assays suggested the absence of known human proteins sharing the key amino acid residues required for recognition by the TCR, suggesting that the TCR could be safely used in patients. These data provide us with a strong basis ...
Highly recurrent mutations in H3F3A, which encodes the histone H3 variant H3.3, and HIST1H3B, which encodes the histone H3 variant H3.1, have recently been identified in pediatric gliomas. Remarkably, these mutations invariably occur at or near sites of key regulatory posttranslational modifications, namely Lys27 and Gly34, suggesting that these cancers may be driven by altered epigenetic states. Lewis and colleagues analyzed global levels of regulatory histone modifications in diffuse intrinsic pontine glioma (DIPG) samples with H3.1 or H3.3 Lys27Met (K27M) mutations and specifically found decreased levels of H3K27 trimethylation (H3K27me3) and increased H3K27 acetylation compared with non-K27M mutant DIPGs. The finding that H3K27me3 was globally reduced despite the low contribution of mutant histone variants to total cellular histone H3 levels indicated that K27M expression reduces methylation on wild-type H3 histones. Indeed, nucleosomes purified from K27M-expressing cells had markedly lower ...
Background and Purpose: Radiation therapy is the traditional and only therapy that offers benefits to patients with diffuse intrinsic pontine gliomas (DIPG) which are highly aggressive pediatric central nervous system tumors without known curative therapies. However, unfortunately, efficacy of radiation therapy is transient. Seneca Valley virus-001(SVV-001) is a novel non-pathogenic oncolytic piconavirus that can be systemically administered and pass through brain blood barrier (BBB). Phase I clinical trial of SVV has proven its efficacy in adults patients with cancers with neuroendocrine features and in pediatric patients with non-central nerve system (CNS) tumors. We sought to examine if combining ionizing radiation with an oncolytic virus SVV-001 would lead to synergistically enhanced tumor cell killing and significantly improve therapeutic efficacy in vivo in DIPG patient tumor-derived intra-brain stem orthotopic xenograft mouse models (PDOX).. Methods: By infecting PDOX derived tumor cells ...
Diffuse pontine gliomas are tumors on the pons portion of the brainstem. Their peak incidence is in children between 5 and 10 years old. Their location
Brain tumor news: A prospective study of temozolomide plus thalidomide during and after radiation therapy for pediatric diffuse pontine gliomas: preliminary results of the Korean Society for Pediatric Neuro-Oncology study.
DARIEN, Ill. -- In September of 2016, Joey Ventimiglia, who was 6 at the time, was diagnosed with DIPG. DIPG, Diffuse Intrinsic Pontine Glioma, is a brain tumor that rests in the pons of the brain.
Diffuse intrinsic pontine glioma (DIPG) is the deadliest brainstem cancer in children, and significant therapeutic progress has not been made in decades. DIPG is resistant to pro-apoptotic chemotherapeutics, exhibits a profile of oxidative stress, and has disrupted cellular metabolism. Ferroptosis is an iron-dependent form of cell death mediated by the accumulation of toxic
DARIEN, Ill. - In September of 2016, Joey Ventimiglia, who was 6 at the time, was diagnosed with DIPG. DIPG, Diffuse Intrinsic Pontine Glioma, is a brain tumor that rests in the pons of the brain. This area controls essential bodily functions such as the heartbeat, breathing, eyesight, and balance. What
TY - JOUR. T1 - Carotid cavernous fistula imitating brainstem glioma. AU - Clark, Stephen W.. AU - Dang, Toan. AU - Toth, Gabor. AU - Pride, Glenn L.. AU - Greenberg, Benjamin. AU - Warnack, Worthy. PY - 2011/2. Y1 - 2011/2. UR - http://www.scopus.com/inward/record.url?scp=79951537591&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=79951537591&partnerID=8YFLogxK. U2 - 10.1001/archneurol.2010.366. DO - 10.1001/archneurol.2010.366. M3 - Article. C2 - 21320994. AN - SCOPUS:79951537591. VL - 68. SP - 256. EP - 257. JO - Archives of Neurology. JF - Archives of Neurology. SN - 0003-9942. IS - 2. ER - ...
Childhood CNS germ cell tumors form in germ cells, which are cells that develop into sperm or ova (eggs). There are different types of childhood germ cell tumors. These include germinomas, embryonal yolk sac carcinomas, choriocarcinomas, and teratomas. A mixed germ cell tumor has two types of germ cell tumors in it. Germ cell tumors can be either benign or malignant.. Germ cell brain tumors usually form in the center of the brain, near the pineal gland. The pineal gland is a tiny organ in the brain that makes melatonin, which is a substance that helps control the sleeping and waking cycle. Germ cell tumors can spread to other parts of the brain and spinal cord.. ...
Phase I clinical trial of p28 in pediatric patients with Recurrent or Progressive CNS tumors. We recently completed a national, multi-center trial (9 institutions) Phase I a, b clinical trial of p28 (NSC7451040) in pediatric patients with recurrent or progressive CNS tumors supported by the Pediatric Brain Tumor Consortium (PBTC-041) and NCI-DCT-CTEP.. ASCO 2015 Poster: Phase 1 Trial of p28 (NSC745104), A Non-HDM2 Mediated Peptide Inhibitor of p53 Ubiquitination in Children with Recurrent or Progressive CNS Tumors: A Final Report from the Pediatric Brain Tumor Consortium Report Pediatric patients were administered p28 i.v. 3 times weekly for 4 consecutive weeks of a 6-week cycle at 4.16 mg/kg/dose (50 mg/kg/course) using a rolling 6 study design. Serum pharmacokinetics were established. A total of 18 patients were registered on the study, 12 patients with malignant glioma, choroid plexus carcinoma, medulloblastoma, pineoblastoma, DIPG and AT/RT completed the DLT period and were evaluable for ...
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A glioma is a type of tumor that starts in the brain or spine. Gliomas arise from glial cells, which act as a supportive cell in the central nervous system. Gliomas are the second most common type of tumor after meningiomas.. There are three types of normal glial cells that can produce tumors. An astrocyte will produce astrocytomas (including glioblastomas), an oligodendrocyte will produce oligodendrogliomas, and ependymomas come from ependymal cells. Tumors that display a mixture of these different cells are called mixed gliomas. Tumors are also commonly identified by their specific locations (such as brain stem gliomas), not the tissue type from which they originate.. Gliomas are also categorized by grade, determined by pathologic evaluation of the tumor. Of numerous grading systems in use, the most common is the World Health Organization (WHO) grading system for astrocytoma, under which tumors are graded from I (least advanced disease / best prognosis) to IV (most advanced disease / worst ...
Original Research and Commentary on p28 CDG Therapeutics Lead Agent and Analogs. Binding of Amphipathic Cell Penetrating Peptide p28 to Wild Type and Mutated p53 as studied by Raman, Atomic Force and Surface Plasmon Resonance spectroscopies.. Signorelli S, Santini S, Yamada T, Bizzarri AR, Beattie CW, Cannistraro S.. Biochim Biophys Acta. 2017 Apr;1861(4):910-921.. Phase 1 trial of p28 (NSC745104), a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in pediatric patients with recurrent or progressive central nervous system tumors: A Pediatric Brain Tumor Consortium Study.. Lulla RR, Goldman S, Yamada T, Beattie CW, Bressler L, Pacini M, Pollack IF, Fisher PG, Packer RJ, Dunkel IJ, Dhall G, Wu S, Onar A, Boyett JM, Fouladi M.. Neuro Oncol., 2016 Sep;18(9):1319-25. p28-mediated Activation of p53 in G2/M Phase of the Cell Cycle Enhances the Efficacy of DNA Damaging and Antimitotic Chemotherapy.. Yamada T, Das Gupta TK, Beattie CW.. Cancer Res. 2016 Feb 26; 76(8): 2354-2365. Chirality ...
According to results from phase II studies conducted through the Pediatric Brain Tumor Consortium, a subtype of the brain stem tumor medulloblastoma may respond to vismodegib (Erivedge; Genentech)-approved for basal cell carcinomas-with less toxicity than current standard therapy. Both cancers arise from aberrant Sonic hedgehog (SHH) pathway activity; vismodegib inhibits a key protein, Smoothened (SMO), in this signaling cascade.. Medulloblastomas SHH subtype (SHH-MB) occurs in about 60% of adult and 25% of pediatric patients. Initial treatment involves a combination of surgery, radiation, and cytotoxic therapy, with a 5-year overall survival of 70%. However, patients are often left with severe long-term side effects, and a grim prognosis if the tumor recurs.. We need a therapy that is less toxic and better honed to its target, says corresponding author Giles Robinson, MD, a pediatric neuro-oncologist at St. Jude Childrens Research Hospital in Memphis, TN.. The studies enrolled 31 adults and ...
PURPOSE: To use multimodal magnetic resonance imaging (MRI) to quantify treatment-induced changes in the whole volume of diffuse infiltrating pontine gliomas and correlate them with progression-free survival (PFS). METHODS AND MATERIALS: This prospective study included 22 children aged 3.3 to 14.7 years (median, 5.9 years). Multimodal MRI was performed at 3 distinct time points: before treatment, the first week following radiation therapy (RT), and 2 months after RT. The imaging protocol included morphologic, multi b-value diffusion; arterial spin labeling; and dynamic susceptibility contrast-enhanced perfusion. Morphologic and multimodal data-lesion volume, diffusion coefficients, relative cerebral blood flow, and relative cerebral blood volume (rCBV)-were recorded at the 3 aforementioned time points. The Wilcoxon test was used to compare each individual parameter variation between time points, and its correlation with PFS was assessed by the Spearman test. RESULTS: Following RT, the tumors ...
Conditions: Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Sarcoma; Colorectal Neoplasms; Salivary Gland Neoplasms; Biliary Tract Neoplasms; Brain Neoplasm, Primary; Carcinoma, Ductal, Breast; Melanoma; Solid Tumors; Glioblastoma; Bile Duct Neoplasms; Astrocytoma; Head and Neck Squamous Cell Carcinoma; Pontine Glioma; Pancreatic Neoplasms; Ovarian Neoplasms; Carcinoma, Renal Cell; Cholangiocarcinoma; Carcinoma; Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms, Nerve Tissue; Nevi and ...
http://www.cristianriverafoundation.org On January 22nd, 2007, 4-year-old Cristian was diagnosed with Pontine Glioma, which is an ...
The results of the study will be presented during a press conference today at the AACR Annual Meeting 2012 in Chicago.. The study, led by Ian F. Pollack, M.D., F.A.C.S., F.A.A.P., chief, Pediatric Neurosurgery at Childrens Hospitals Brain Care Institute and co-director of UPCIs Brain Tumor Program, and Dr. Regina I. Jakacki, M.D., director of Pediatric Neuro-Oncology, enrolled 27 children with gliomas, including 16 with newly diagnosed brainstem gliomas, five with newly diagnosed cerebral high-grade gliomas and six with recurrent gliomas. Each child received serial doses of a peptide vaccine, which stimulates an immune response to a protein fragment present on their tumor cells.. Weve found that this vaccine is tolerated well with limited systemic toxicity, but weve also observed that there are some patients who have immunological responses in the vaccine target in the brain that can cause swelling and transient worsening and, subsequently, some of those children can have very favorable ...
The Adult Brainstem Glioma online support group is a private email list consisting of adults dealing with the diagnosis of a brain stem tumor and their caregivers. Researchers and clinicians are also welcome.. No Cost ...
Cardio-facio-cutaneous syndrome Malignant melanoma Carcinoma of colon Papillary thyroid carcinoma Astrocytoma, low-grade, somatic Germ cell tumor, nonseminomatous Non-small cell lung cancer not provided Malignant melanoma of skin Colonic Neoplasms Squamous cell carcinoma of the head and neck Brainstem glioma Glioblastoma Adenocarcinoma of lung Multiple myeloma Ovarian Neoplasms Lung cancer Neoplasm of brain Gastrointestinal stromal tumor Papillary renal cell carcinoma, sporadic Neoplasm Colorectal Neoplasms ...
Duke University Medical Center A collaborative effort between Duke Medicine researchers and neurosurgeons and scientists in China has produced new genetic insights into a rare and deadly form of childhood and young adult brain cancer called brainstem glioma.. The researchers identified a genetic mutation in the tumor cells that plays a role in both the growth and the death of a cell. Additionally, the mutation to the newly identified gene may also contribute to the tumors resistance to radiation.. The findings, published online in the journal Nature Genetics on June 1, 2014, provide both immediate and long-term benefits. Knowing that this mutation may render radiation ineffective, patients could be spared that therapy. The mutation would also serve as a strong candidate for drug development.. The researchers conducted genetic tests and found that many of the tumor cells had a mutation in a gene called PPM1D, which causes cells to proliferate and avoid natural death. It is the first time this ...
Abnormal growth of cells in the nervous system without evidence of malignant characteristics. Unlike other organ systems, tumors in the central nervous system can have benign histological characteristics but still have life threatening effects due to their location within the neuraxis (e.g., brainstem gliomas ...
Its of course mainly glioblastoma histologically = glioma grade 4 = most aggressive and resistant to treatment - if there was anything except radiation, which gives only temporary relief. On the other hand, surgery and chemo possible in case of glioblastoma multiforme, also doesnt make the positive outcome: ...
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... or confusion Brain stem - Tetraparesis, facial weakness, decreased level of consciousness, gaze paresis, ocular bobbing, miosis ... Hemorrhagic neoplasms are more complex, heterogeneous bleeds often with associated edema. These hemorrhages are related to ... A CT scan is the best test to look for bleeding in or around your brain. In some hospitals, a perfusion CT scan may be done to ... In some hospitals, a perfusion MRI scan may be done to see where the blood is flowing and not flowing in your brain. Angiogram ...
... syndrome Braddock-Jones-Superneau syndrome Bradykinesia Brain cavernous angioma Brain neoplasms Brain stem neoplasms Branchial ... Birt-Hogg-Dubé syndrome Bixler-Christian-Gorlin syndrome Björnstad syndrome BK virus nephritis Black piedra Bladder neoplasm ... craniosynostosis proptosis hydrocephalus Bone marrow failure neurologic abnormalities Bone marrow failure Bone neoplasms Bone ...
4. Brain Stem Gliomas Brain stem glioma is a distinct category of central nervous system tumor because of its unique location ... Neuro-oncology is the study of brain and spinal cord neoplasms, many of which are (at least eventually) very dangerous and life ... and brain stem tumors are among the many examples of these). Among the malignant brain cancers, gliomas of the brainstem and ... The histology of brain stem gliomas spans the spectrum of gliomas located elsewhere in the central nervous system. The cause of ...
It is caused by lesions of the upper brain stem and is named for Henri Parinaud (1844-1905), considered to be the father of ... trauma and brainstem toxoplasmosis infection. Neoplasms and giant aneurysms of the posterior fossa have also been associated ... Classically, it has been associated with three major groups: Young patients with brain tumors in the pineal gland or midbrain: ... Women in their 20s-30s with multiple sclerosis Older patients following stroke of the upper brainstem However, any other ...
Brain neoplasms. *Brain stem neoplasms. *Branchial arch defects. *Branchial arch syndrome X linked ...
"Stem cell marker expression in the Bergmann glia population of the adult mouse brain". Brain Research. 1099 (1): 8-17. doi: ... Misago N, Narisawa Y (September 2006). "Cytokeratin 15 expression in neoplasms with sebaceous differentiation". Journal of ... Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. Stem cells can ... 2005). "Somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitors". Stem Cells. 23 (6 ...
... brain stem neoplasms MeSH C10.228.140.211.500.200 - cerebellar neoplasms MeSH C10.228.140.211.692 - neurocytoma MeSH C10.228. ... brain stem neoplasms MeSH C10.551.240.250.400.300 - cerebellar neoplasms MeSH C10.551.240.250.550 - neurocytoma MeSH C10.551. ... brain neoplasms MeSH C10.228.140.211.280 - cerebral ventricle neoplasms MeSH C10.228.140.211.280.300 - choroid plexus neoplasms ... brain neoplasms MeSH C10.551.240.250.200 - cerebral ventricle neoplasms MeSH C10.551.240.250.200.200 - choroid plexus neoplasms ...
Of the above malignant characteristics, some elements do not apply to primary neoplasms of the brain: *Primary brain tumors ... Brain stem: Tumors on this can affect blood pressure, swallowing, and heartbeat.[citation needed] ... Secondary brain tumorsEdit. Secondary tumors of the brain are metastatic and have invaded the brain from cancers originating in ... A brain tumor occurs when abnormal cells form within the brain.[2] There are two main types of tumors: malignant or cancerous ...
Of the above malignant characteristics, some elements do not apply to primary neoplasms of the brain: *Primary brain tumors ... "Brain Stem Gliomas in Childhood". Childhoodbraintumor.org. Archived from the original on 9 March 2012. Retrieved 17 February ... "Brain Tumors". Children's Hospital of Wisconsin. 6 March 2019.. *^ a b c Jones, Caleb. "Brain Tumor Symptoms , Miles for Hope ... "Central Brain Tumor Registry of the United States. 31 March 2019.. *^ "Brain, other CNS and intracranial tumours statistics". ...
Neoplasm Neuroepithelial cell Astrocytes Glial cells Brain cancer Astroblastoma at Curlie Unal, Ekrem, and Yavuz Koksal. " ... This specific genetic makeup lends to self-renewal, differentiation, and propagation of neural stem cells in the brain. However ... and brain stem. The most defining physical symptom of astroblastoma, regardless of location, is elevated intracranial pressure ... often mistaking astroblastoma with glial neoplasms, high-grade astrocytes, and embryonal neoplasms. However, the "bubbly" ...
... (Nnat) is a protein coding gene involved in mammalian brain development. It is located on Chromosome 20 in humans ... Neuronatin begins the differentiation of pluripotent stem cells into cells with a neural fate by increasing their calcium ... The loss of methylation within these areas triggers an irregular cell growth, resulting in embryonic neoplasms. Numata, Shusuke ... It is also expressed in several tissues outside of the brain. For example, expression in skin cells controls the ...
Primary familial brain calcification (see Fahr's syndrome) is a rare disease involving bilateral calcifications in the brain, ... This continuous signaling, it is presumed, leads to the development of myeloid and/or lymphoid neoplasms that commonly include ... Heldin CH, Lennartsson J (August 2013). "Structural and functional properties of platelet-derived growth factor and stem cell ... It is proposed that signal transduction through PDGFRB maintains blood-brain barrier integrity and that loss of the PDGFRB ...
Uncommon neurological symptoms like migraines, seizures, or coma can occur as a result of brain stem pressure. All symptoms ... Reiter A, Gotlib J (2017). "Myeloid neoplasms with eosinophilia". Blood. 129 (6): 704-714. doi:10.1182/blood-2016-10-695973. ... CNS prophylaxis (preventive therapy) to stop the cancer from spreading to the brain and nervous system in high-risk patients. ... These can potentially show leukemia's effects on such body parts as bones (X-ray), the brain (MRI), or the kidneys, spleen, and ...
... such as brain herniation. Mass lesions in the brain stem normally cause coma due to their effects on the reticular formation. ... Neoplasms within the intracranial cavity can also affect consciousness, as can epilepsy and post-seizure states. A decreased ... Normally, stupor and coma are produced by interference with the brain stem, such as can be caused by a lesion or indirect ... A pH outside of the range the brain can tolerate will also alter LOC. Exposure to drugs (e.g. alcohol) or toxins may also lower ...
Cheng JX, Liu BL, Zhang X (August 2009). "How powerful is CD133 as a cancer stem cell marker in brain tumors?". Cancer ... "CD133 expression pattern distinguishes intraductal papillary mucinous neoplasms from ductal adenocarcinomas of the pancreas" ( ... CD133 is expressed in hematopoietic stem cells, endothelial progenitor cells, glioblastoma, neuronal and glial stem cells, ... "Cancerous stem cells can arise from pediatric brain tumors". Proceedings of the National Academy of Sciences of the United ...
Uncommon neurological symptoms like migraines, seizures, or coma can occur as a result of brain stem pressure. All symptoms ... These disorders may evolve into chronic eosinophilic leukemia or may be associated with various forms of myeloid neoplasms, ... The stem cells that cause different types of leukaemia are also being researched. Leukemia is rarely associated with pregnancy ... These can potentially show leukemia's effects on such body parts as bones (X-ray), the brain (MRI), or the kidneys, spleen, and ...
... until a stem cell arose that generated either small polyps (which may be benign neoplasms) or else a malignant neoplasm (cancer ... In gliomas, a form of brain cancer, radiation therapy appears to select for stem cells,[116][117] though it is unclear if the ... Cancer stem cells[edit]. Main article: Cancer stem cell. The first malignant cell, that gives rise to the tumor, is often ... The monoclonal model of cancer and the cancer stem-cell model are not mutually exclusive.[90] Cancer stem cell arises by clonal ...
... and will open great interests for clinical applications in stem‐cell‐based therapy. Direct nose-to-brain drug delivery is being ... "A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option". ... The brain has a limited capacity to repair itself. Many drugs cannot cross the blood-brain barrier to act on the tumor. ... It is the most common cancer that begins within the brain and the second-most common brain tumor, after meningioma. About 3 in ...
... brain hemorrhage, traumatic MeSH C21.866.915.300.200.175.200 - brain stem hemorrhage, traumatic MeSH C21.866.915.300.200.175. ... neoplasms, radiation-induced MeSH C21.866.733.579 - osteoradionecrosis MeSH C21.866.733.720 - radiation injuries, experimental ... brain hemorrhage, traumatic MeSH C21.866.915.300.490.150.200 - brain stem hemorrhage, traumatic MeSH C21.866.915.300.490.150. ... brain hemorrhage, traumatic MeSH C21.866.260.118.175.150 - brain stem hemorrhage, traumatic MeSH C21.866.260.118.175.300 - ...
The proximity of chordomas to vital neurological structures such as the brain stem and nerves limits the dose of radiation that ... Chordoma is a rare slow-growing neoplasm thought to arise from cellular remnants of the notochord. The evidence for this is the ...
Hence, a neural stem cell can give rise to another neural stem cell, or to any of the differentiated cell types found in the ... To localize mRNA in brain tissue, one can use a fragment of DNA or RNA as a neuronal lineage marker, a hybridization probe that ... In pathological conditions was also reported that glial neoplasms and reactive glial cells expressed this marker. Calretinin is ... Neural stem cells are an example of somatic stem cell found in various tissues, both during development and in the adult. They ...
Cell Stem Cell. 20 (4): 518-532.e9. doi:10.1016/j.stem.2016.11.005. PMC 5384872. PMID 28017796.. ... "GT1b in human metastatic brain tumors: GT1b as a brain metastasis-associated ganglioside1Ganglioside nomenclature is based on ... Its expression is also increased in a wide range of other malignant neoplasms. Factor X (F10) is frequently expressed in normal ... "Differential expression profiles of glycosphingolipids in human breast cancer stem cells vs. cancer non-stem cells". ...
Hyperventilation can occur when the brain stem or tegmentum is damaged. As a rule, patients with normal blood pressure retain ... In cases of confirmed brain neoplasm, dexamethasone is given to decrease ICP. Although the exact mechanism is unknown, current ... shift brain structures, contribute to hydrocephalus, cause brain herniation, and restrict blood supply to the brain. It is a ... This type of drain is known as an external ventricular drain (EVD). This is rarely required outside brain injury and brain ...
Pluripotent stem cells including human induced pluripotent stem cells have a unique property of being able to generate ... Saito K, Katsumata Y, Hirabuki T, Kato K, Yamanaka M (2007). "Fetus-in-fetu: parasite or neoplasm? A study of two cases". Fetal ... Teratomas derived from embryonic cells usually occur on the subject's midline: in the brain, elsewhere in the skull, in the ... "Human Induced Pluripotent Stem Cells Develop Teratoma More Efficiently and Faster Than Human Embryonic Stem Cells Regardless ...
Treatments for AML like chemotherapy or stem cell transplant can trigger side effects. People that receive a stem cell ... p. I. ISBN 978-0-19-503448-6. Aoki K, Kurihars M, Hayakawa N (1992). Death Rates for Malignant Neoplasms for Selected Sites by ... Occasionally, spread may occur to the brain, skin, or gums. As an acute leukemia, AML progresses rapidly and is typically fatal ... and whether a suitable stem cell donor is available. For people who are not eligible for a stem cell transplant, immunotherapy ...
... (GCT) is a neoplasm derived from germ cells. Germ-cell tumors can be cancerous or benign. Germ cells normally ... Embryonic stem cells Cancer research Maoz, Asaf; Matsuo, Koji; Ciccone, Marcia A.; Matsuzaki, Shinya; Klar, Maximilian; Roman, ... Brain & Development. 39 (5): 448-451. doi:10.1016/j.braindev.2016.12.003. PMID 28040316. S2CID 8224022. Ulbright TM (February ... of all germ cell neoplasms pelvis, particularly sacrococcygeal teratoma In females, GCTs account for 30% of ovarian tumors, but ...
... brain stem neoplasms MeSH C04.588.614.250.195.411.211 - cerebellar neoplasms MeSH C04.588.614.250.195.648 - neurocytoma MeSH ... central nervous system neoplasms MeSH C04.588.614.250.195 - brain neoplasms MeSH C04.588.614.250.195.205 - cerebral ventricle ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588.274.120.250.250 - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ...
In contrast, SKIDA1 expression in the fetal brain is higher than in the adult brain. SKIDA1 in the African clawed frog is ... US 9994911, Ahlquist DA, Kisiel JB, Taylor WR, Yab TC, Mahoney DW, Lidgard GP, Allawi HT, "Detecting Neoplasm", issued 12 June ... Transcriptome analysis of induced pluripotent stem cells from monozygotic twins discordant for trisomy 21". Genomics Data. 2: ... SKIDA1 is expressed at high levels in the brain, thyroid, and testes. It's expressed at medium to low levels in adipose tissue ...
Preganglionic parasympathetic fibers leave the brain stem from inferior salivatory nucleus in the glossopharyngeal nerve and ... Pleomorphic adenoma is seen to be a common benign neoplasm of the salivary gland and has an overall incidence of 54-68%. The ... Pain is more common in patients with parotid cancer (10-29% feel pain) than those with benign neoplasms (only 2.5-4%), but pain ... The word parotid literally means "beside the ear". From Greek παρωτίς (stem παρωτιδ-) : (gland) behind the ear < παρά - pará : ...
... blood-brain barrier - body fat redistribution (BFR) syndrome - body fluids - bone marrow - bone marrow suppression - booster - ... stem cells (FDCs) - steroid - Stevens-Johnson syndrome - STI - stomatitis - strain - stratification - structured intermittent ... neoplasm - nephrotoxic - neuralgia - neurological complications of AIDS - neuropathy - neutralization - neutralizing antibody ...
Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ... Source of cancer stem cells' resistance to radiation explained on YouTube.. *Cancer Management Handbook: Principles of ... This is a concern during treatment of brain tumors and brain metastases, especially where there is pre-existing raised ... Cancer cells are generally less differentiated and more stem cell-like; they reproduce more than most healthy differentiated ...
"Islet Cell Tumors of the Pancreas / Endocrine Neoplasms of the Pancreas". The Sol Goldman Pancreas Cancer Research Center. ... Zhan HX, Xu JW, Wu D, Zhang TP, Hu SY (2015). "Pancreatic cancer stem cells: New insight into a stubborn disease". Cancer Lett ... See page 95 for citation regarding "... lesser degree of involvement of bones and brain and other anatomical sites." ... Farrell JJ, Fernández-del Castillo C (juni 2013). "Pancreatic cystic neoplasms: management and unanswered questions". ...
doi:10.1016/j.stem.2012.03.009. PMC 3348510 . PMID 22560078.. *^ Maitland NJ, Collins AT (2008). "Prostate cancer stem cells-a ... "Male Genitals - Prostate Neoplasms". Pathology study images. University of Virginia School of Medicine. Archived from the ... PC-3 and DU-145 cells were established from human prostatic adenocarcinoma metastatic to bone and to brain, respectively. LNCaP ... It is possible that for further advances, a combination of androgen signaling blocking agent with stem-like cell directed ...
A brain-stem glioma in four year old. MRI ಸ್ಯಾಗಿಟಲ್, ಉತೌಟ್ ಕಾಂಟ್ರಾಸ್ಟ್ ... "CNS and Miscellaneous Intracranial and Instraspinal Neoplasms" (PDF). SEER Pediatric Monograph. National Cancer Institute. pp ... It has been suggested that [[::Malignant brain tumor,Malignant brain tumor]] be merged into this article or section. (Discuss) ... Infantile Brain Tumors by Brian Rood for The Childhood Brain Tumor Foundation (accessed July 2007) ...
Additional treatments may include intrathecal chemotherapy or radiation therapy if spread to the brain has occurred.[2] Stem ... "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): ... can determine whether the spinal column and brain have been invaded. Brain and spinal column involvement can be diagnosed ... Chemotherapy, stem cell transplantation, radiation therapy, targeted therapy[1]. Prognosis. Children: 90% five-year survival ...
The blood-brain barrier poses a difficult obstacle to pass to deliver chemotherapy to the brain. This is because the brain has ... Secondary neoplasm[edit]. Development of secondary neoplasia after successful chemotherapy or radiotherapy treatment can occur ... In very severe myelosuppression, which occurs in some regimens, almost all the bone marrow stem cells (cells that produce white ... Drug transporters can pump out drugs from the brain and brain's blood vessel cells into the cerebrospinal fluid and blood ...
Note: Not all brain tumors are of nervous tissue, and not all nervous tissue tumors are in the brain (see brain metastasis).. ... Nervous tissue tumors/NS neoplasm/Neuroectodermal tumor (ICD-O 9350-9589) (C70-C72, D32-D33, 191-192/225) ... Newer treatments, such as high dose chemotherapy combined with autologous stem cell transplant are proving to increase survival ... A primary central nervous system lymphoma (PCNSL), also known as microglioma and primary brain lymphoma,[1] is a primary ...
... such as brain herniation.[9] Mass lesions in the brain stem normally cause coma due to their effects on the reticular formation ... Neoplasms within the intracranial cavity can also affect consciousness,[12] as can epilepsy and post-seizure states.[9] A ... Normally, stupor and coma are produced by interference with the brain stem, such as can be caused by a lesion or indirect ... A lowered level of consciousness indicate a deficit in brain function.[4] Level of consciousness can be lowered when the brain ...
The main use of cyclophosphamide is with other chemotherapy agents in the treatment of lymphomas, some forms of brain cancer, ... Bernatsky S, Clarke AE, Suissa S (February 2008). "Hematologic malignant neoplasms after drug exposure in rheumatoid arthritis ... "Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent hematopoietic stem cells to ... Myeloproliferative neoplasms, including acute leukemia, non-Hodgkin lymphoma and multiple myeloma, occurred in 5 of 119 ...
Besco JA, Hooft van Huijsduijnen R, Frostholm A, Rotter A (October 2006). "Intracellular substrates of brain-enriched receptor ... Polyak K, Weinberg RA (April 2009). "Transitions between epithelial and mesenchymal states: acquisition of malignant and stem ... Neoplasm: Tumor suppressor genes/proteins and Oncogenes/Proto-oncogenes. Ligand. Growth factors. ... protein tyrosine phosphatase rho (RPTPrho/PTPRT)". Brain Research. 1116 (1): 50-7. doi:10.1016/j.brainres.2006.07.122. PMID ...
Majumder, edited by Sadhan (2009). Stem cells and cancer (Online-Ausg. ed.). New York: Springer. p. 193. ISBN 978-0-387-89611-3 ... Primary lung cancers themselves most commonly metastasize to the brain, bones, liver and adrenal glands.[6] Immunostaining of a ... Horn, L; Lovly, CM; Johnson, DH (2015). "Chapter 107: Neoplasms of the lung". In Kasper, DL; Hauser, SL; Jameson, JL; Fauci, AS ... The cell lines of origin are not fully understood.[1] The mechanism may involve abnormal activation of stem cells. In the ...
Majumder S. Stem cells and cancer Online-Ausg. New York: Springer. 2009: 193. ISBN 978-0-387-89611-3. (原始内容存档于2015-10-18).. ... Chapter 107: Neoplasms of the lung. (编) Kasper DL, Hauser SL, Jameson JL, Fauci AS, Longo DL, Loscalzo J. Harrison's Principles ... D'Antonio C, Passaro A, Gori B, Del Signore E, Migliorino MR, Ricciardi S, Fulvi A, de Marinis F. Bone and brain metastasis in ... Mulvihill MS, Kratz JR, Pham P, Jablons DM, He B. The role of stem cells in airway repair: implications for the origins of lung ...
The mutations can be inherited or acquired, and most probably occur in the intestinal crypt stem cell.[37][38][39] The most ... "Brain Behav. Immun. 30: S75-87. doi:10.1016/j.bbi.2012.05.001. PMC 3638811. PMID 22610066.. ... Srikumar Chakravarthi; Baba Krishnan; Malathy Madhavan (1999). "Apoptosis and expression of p53 in colorectal neoplasms". ... These genes are normally important for stem cell renewal and differentiation, but when inappropriately expressed at high levels ...
Comparison of Neoplasms in Six Sources of Rats *^ Diamond JM (January 2006). Collapse: How Societies Choose to Fail or Succeed ... Rat traversing complex terrain under the influence of electrode inputs to its brain ... which lend themselves better to the embryonic stem cell techniques typically used for genetic manipulation. Many investigators ... A 1972 study compared neoplasms in Sprague Dawley rats from six different commercial suppliers and found highly significant ...
Brain-stem auditory evoked potentials demonstrate delayed interpeak latencies (IPLs) I-III, III-V and I-V. Toxic overdoses ... These were cancers of the brain, lung, bowel, breast, and bladder, and other neoplasms. Not only are benzodiazepines associated ... In a brain sample of a fatal nitrazepam poisoning high concentrations of nitrazepam and its metabolite were found in the brain ... "Short latency somatosensory evoked potentials and brain-stem auditory evoked potentials in coma due to CNS depressant drug ...
I61.3) Intracerebral haemorrhage in brain stem. *(I61.4) Intracerebral haemorrhage in cerebellum. *(I61.5) Intracerebral ... Neoplasms III D50-D89 Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism ...
"Islet Cell Tumors of the Pancreas / Endocrine Neoplasms of the Pancreas". The Sol Goldman Pancreas Cancer Research Center. ... Zhan HX, Xu JW, Wu D, Zhang TP, Hu SY (2015). "Pancreatic cancer stem cells: New insight into a stubborn disease". Cancer Lett ... See page 95 for citation regarding "... lesser degree of involvement of bones and brain and other anatomical sites." ... Pancreatic mucinous cystic neoplasms are a broad group of pancreas tumors that have varying malignant potential. They are being ...
Hein G, Singer T (2008). "I feel how you feel but not always: the empathic brain and its modulation". Curr. Opin. Neurobiol. 18 ... "Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes". Proceedings of the National Academy of ... Bartz JA, Hollander E (2008). "Oxytocin and experimental therapeutics in autism spectrum disorders". Progress in Brain Research ... 2006). "Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery". Science ...
Mast cells express a cell surface receptor, c-kit[11] (CD117), which is the receptor for stem cell factor (scf). In laboratory ... "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): ... "Mixed organic brain syndrome as a manifestation of systemic mastocytosis". Psychosom Med. 48 (6): 437-47. doi:10.1097/00006842 ... Allogeneic stem cell transplantation has been used in rare cases with aggressive systemic mastocytosis in patients deemed to be ...
Scientists discover thymus stem cells, No. 38c3e, 22.08.2014. *Kathleen E Sullivan, E. Richard Stiehm, Stiehm's Immune ... Tseng-Tong Kuo, Classification of thymic epithelial neoplasms: a controversial issue coming to an end?, J.Cell.Mol.Med. 5. ... Kendall MD, al-Shawaf AA., Innervation of the rat thymus gland., Brain Behav Immun. märts 1991 ;5(1):9-28., (vaadatud 4.10.2014 ... Kendall MD, al-Shawaf AA., Innervation of the rat thymus gland., Brain Behav Immun. märts 1991;5(1):9-28., märts 1991 ...
... until stem cells arise that generate either small polyps or else a malignant neoplasm (cancer). In the photo, an apparent field ... and neural progenitor cells from adipose-derived stem cells to preserve neurovascular structures in rat hypoxic-ischemic brain ... termed Cancer Stem Cell. Cancer stem cells may arise from transformation of adult stem cells or differentiated cells within a ... Cancer stem cells[edit]. Main article: Cancer stem cell. A new way of looking at carcinogenesis comes from integrating the ...
... brain stem dysfunction, myelopathy, mononeuritis multiplex, Guillain-Barré-like syndrome, and antiganglioside-positive ... also EATL is the most common neoplasm.[7] ... "Brain white-matter lesions in celiac disease: a prospective ... According to recent studies, calcifications of channels seen in dementia can also occur in specific brain areas such as the ... One prime example is calcium channel obstruction in the brain and dementia.[80][81] There is a growing body of evidence ...
腫瘤:內分泌腺腫瘤(C73-C75/D34-D35、193-194/226-227(英語:List of ICD-9 codes 140-239: neoplasms#Malignant neoplasm of other and unspecified ... Pancreatic cancer stem cells: New insight into a stubborn disease. Cancer Lett. 2015, 357 (2): 429-37. PMID 25499079. doi: ... See page 95 for citation regarding "... lesser degree of involvement of bones and brain and other anatomical sites." ... 最後一種則是主要發生在女性的胰黏液性囊狀腫瘤(英語:pancreatic mucinous
Brain stem neoplasms - Tumor of the brain stem, is clearly explained in Medindia s glossary of medical terms ... Brain stem neoplasms - Glossary. Written & Compiled by Medindia Content Team. Medically Reviewed by The Medindia Medical Review ...
"Brain Stem Neoplasms" by people in this website by year, and whether "Brain Stem Neoplasms" was a major or minor topic of these ... "Brain Stem Neoplasms" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Primary brain stem neoplasms are more frequent in children. Histologic subtypes include GLIOMA; HEMANGIOBLASTOMA; GANGLIOGLIOMA ... Brain Stem Neoplasms*Brain Stem Neoplasms. *Brain Stem Neoplasm. *Neoplasm, Brain Stem ...
ICD-10-CM Neoplasms Index References for C71.7 - Malignant neoplasm of brain stem The ICD-10-CM Neoplasms Index links the ... Malignant neoplasm of brain stem BILLABLE Billable Code Billable codes are sufficient justification for admission to an acute ... C71.7 is a billable ICD code used to specify a diagnosis of malignant neoplasm of brain stem. A billable code is detailed ... DRG Group #054-055 - Nervous system neoplasms without MCC. Related Concepts SNOMET-CT * Primary malignant neoplasm of brain ...
... there are conflicting data on the content of cancer stem cells responsible for recurrence and resistance to chemotherapy in ... Content of stem tumor CD133+ cells in brain neoplasms of different histological type. Lisyaniy N.I.*, Stanetskaya D.N., ... Brain tumour stem cells. Nat Rev Cancer 2006; 6: 425-6.. *7. Dalerba P, Cho R, Clarke M. Cancer stem cells: Models and concepts ... Singh S, Clarke I, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003; 63: 5821-8. ...
Brain Stem Neoplasms / drug therapy. Brain Stem Neoplasms / radiotherapy. Carboplatin / therapeutic use. Glioma / drug therapy ... Brain Stem Neoplasms / drug therapy. Brain Stem Neoplasms / radiotherapy. Glioma / drug therapy. Glioma / radiotherapy ... Brain Neoplasms / drug therapy. Brain Stem Neoplasms / drug therapy. Glioma / drug therapy. Medulloblastoma / drug therapy. ... MeSH-major] Brain Stem Hemorrhage, Traumatic / diagnosis. Brain Stem Neoplasms / diagnosis. Magnetic Resonance Imaging / ...
Neoplasms by Histologic Type. Neoplasms, Glandular and Epithelial. Neoplasms, Nerve Tissue. Neoplasms by Site. Nervous System ... Nervous System Neoplasms. Central Nervous System Neoplasms. Neoplasms, Neuroepithelial. Neuroectodermal Tumors. Neoplasms, Germ ... DNA Analysis of Tumor Tissue Samples From Patients With Diffuse Brain Stem Glioma. The safety and scientific validity of this ... Explore protein expression patterns identified by immunohistochemistry or western blot and compare them to normal brain stem ...
Neoplasms, Germ Cell and Embryonal. Neoplasms by Histologic Type. Neoplasms. Neoplasms, Glandular and Epithelial. Neoplasms, ... Genetic and Rare Diseases Information Center resources: Glioma Diffuse Intrinsic Pontine Glioma Childhood Brain Stem Glioma ... of pediatric brain tumors, and is the most lethal form of brainstem gliomas in children. There is currently no effective ... brainstem tumor and constitutional tissue from patients with diffuse intrinsic pontine glioma or brainstem glioma will be ...
Kjaer M. Brain stem auditory and visual evoked potentials in multiple sclerosis. Acta Neurol Scand. 1980 Jul. 62(1):14-9. [ ... Rowed et al used SEP to identify the somatosensory cortex in an effort to help remove intracranial neoplasms and spare eloquent ... Brainstem Auditory Evoked Potentials. The brainstem auditory evoked potential (BAEP), or brainstem auditory evoked response ( ... Effects of insulin and hypoglycemia on the auditory brain stem response in humans. J Neurophysiol. 1994 Aug. 72(2):678-83. [ ...
Caetano Coimbra, MD, a highly rated Neurosurgery Specialist in Dallas, TX specializing in Meningiomas, Brain Surgery, Subdural ... Coimbra performed a 12 hour surgery to remove my tumor that was pushing my brain stem to the left. It was a very risky surgery ... Brain Cancer. *Brain Disorders. *Brain Surgery. *Brain Tumor. *Brain Tumor Surgery. *Brainstem Neoplasm ... He is incredibly arrogant (he called my surgery baby brain surgery, because it was so easy.) However, I had brain surgery ...
Recent studies indicate that brain tumor cells resemble neural stem cells in terms of phenotype, signaling, and behavior in ... In light of these similarities, it has been suggested that brain tumors arise from stem cells … ... Brain tumors are among the most aggressive and intractable types of cancer. ... Brain Neoplasms / genetics * Brain Neoplasms / pathology* * Cell Differentiation / genetics * Cell Differentiation / physiology ...
Metastatic neoplasms of the brain stem K. M. Hunter and N. B. Rewcastle ...
8. Brain Stem Neoplasms. 9. Cerebellar abscess. 10. Cerebellar ataxia, X-linked. More causes » , Show All 66 Causes , Show ... Brain symptoms (2787 causes) *Clumsiness (408 causes) *Nerve symptoms (9132 causes) *Balance symptoms (1691 causes) *Head ...
... of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem ... Brain Stem Neoplasms / genetics* * Brain Stem Neoplasms / pathology * Genome, Human / genetics * Glioblastoma / genetics* ... Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas Nat Genet. 2012 ... of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem ...
Brain Metastases - Cancer that has spread from the original (primary) tumor to the brain, is clearly explained in Medindia s ... Brain Stem. * Brain Stem Glioma. * Brain stem neoplasmsVer 2. * Brain Stem Tumor ... Medical Word - Brain Metastases. Ans : Cancer that has spread from the original (primary) tumor to the brain. ... Brain Metastases - Glossary. Written & Compiled by Medindia Content Team. Medically Reviewed by The Medindia Medical Review ...
Brain Stem Neoplasms; Breast Cancer; Cervical Cancer; Colorectal Cancer; &n.... Source: ClinicalTrials.gov - July 22, 2019. ... Conditions: Adenocarcinoma; Adenocystic Carcinoma; Anal Cancer; Appendix Cancer; Brain Tumor; Glioblastoma; Astrocytoma; Bile ...
Brain Stem Neoplasms; Breast Cancer; Cervical Cancer; Colorectal Cancer; &n.... Source: ClinicalTrials.gov - July 22, 2019. ... NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance ... More News: Brain , Cancer , Cancer & Oncology , Carcinoma , Clinical Trials , Colon Cancer , Colorectal Cancer , Genetics , ... Conditions: Adenocarcinoma; Adenocystic Carcinoma; Anal Cancer; Appendix Cancer; Brain Tumor; Glioblastoma; Astrocytoma; Bile ...
ACVR1 and Brain Stem Glioma, Childhood. View Publications. 8. Brain Tumours, Childhood. ACVR1 and Brain Tumours. View ... ACVR1 and Brain, Astrocytoma, Childhood. View Publications. 3. Colorectal Cancer. ACVR1 and Colonic Neoplasms. View ... Brain Stem Glioma - Childhood Signal Transduction Wu G, Diaz AK, Paugh BS, et al.. The genomic landscape of diffuse intrinsic ... Brain Stem Glioma - Childhood NTRK1 gene NTRK2 NTRK3 gene Signal Transduction Fontebasso AM, Papillon-Cavanagh S, ...
Brain Stem Neoplasms. Benign and malignant intra-axial tumors of the MESENCEPHALON; PONS; or MEDULLA OBLONGATA of the BRAIN ... Primary brain stem neoplasms are more frequent in children. Histologic subtypes include GLIOMA; HEMANGIOBLASTOMA; GANGLIOGLIOMA ... STEM. Primary and metastatic neoplasms may occur in this location. Clinical features include ATAXIA, cranial neuropathies (see ... A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by ...
... prolong the progression-free survival in brain stem glioma. Dif ... Brain Neoplasms. *Brain Stem Tumor. *Brain Neoplasms. * ... Phase I Study of Vioxx and Radiation Therapy for Brainstem Glioma. Trial Phase:. Phase 1. Minimum Age:. 3 Years. Maximum Age:. ... MRI of the brain with or without gadolinium within 4 weeks of starting therapy.. - Clinical history < 6 months duration. - ... Phase I Study of Vioxx and Radiation Therapy for Brainstem Glioma. Rofecoxib is a non-steroidal anti-inflammatory drug.. ...
Brain Stem Neoplasms / pathology. Cranial Nerve Neoplasms / pathology*, surgery*. Female. Humans. Immunohistochemistry. ...
Neoplasms by Histologic Type. Neoplasms. Brain Infarction. Brain Ischemia. Cerebrovascular Disorders. Brain Diseases. Central ... Brain Stem Infarctions. Disease. Pathologic Processes. Skin Abnormalities. Congenital Abnormalities. Skin Diseases. Hemangioma ...
For patients with 1-6 intraparenchymal brain metastases from various primary histologies (except for melanoma), stereotactic ... Lung Neoplasms. *Neoplasm Metastasis. *Prostatic Neoplasms. *Brain Neoplasms. .map{width:100%;height:300px;margin-bottom:15px} ... receive standard whole brain radiation therapy or whole brain radiation therapy in a neural. stem cell-preserving manner. ... A Study of Neural Stem Cell (NSC) Preserving Whole Brain Radiation Therapy (WBRT) and Stereotactic Radiosurgery in Patients ...
Auditory Brain Stem Implantation. Surgical insertion of an electronic hearing device (AUDITORY BRAIN STEM IMPLANTS) with ... Neoplasm Seeding. The local implantation of tumor cells by contamination of instruments and surgical equipment during and after ... Brain Computer Interface for Communication in ICU: a Feasibility Study. The main objective of this study is to evaluate the ... electrodes to the cochlea nucleus in the BRAIN STEM rather than to the inner ear as in COCHLEAR IMPLANTATION. ...
Kjaer M. Brain stem auditory and visual evoked potentials in multiple sclerosis. Acta Neurol Scand. 1980 Jul. 62(1):14-9. [ ... Somatosensory evoked potential identification of sensorimotor cortex in removal of intracranial neoplasms. Can J Neurol Sci. ... Effects of insulin and hypoglycemia on the auditory brain stem response in humans. J Neurophysiol. 1994 Aug. 72(2):678-83. [ ... Brainstem auditory and visual evoked potentials in infants with myelomeningocele. Brain Dev. 1996 Mar-Apr. 18(2):99-104. [ ...
The biopsied tumor was diagnosed as a glioneuronal neoplasm. We compared the tumor cells and the patients peripheral blood ... A) Brain MRI (T2) demonstrating a lesion (arrow) based on the tentorium, next to the brain stem (BS).. (B) Spinal-lumbar MRI ( ... Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient.. Amariglio N1, ... This is the first report of a human brain tumor complicating neural stem cell therapy. The findings here suggest that neuronal ...
Hunter KMFRewcastle NB: Metastatic neoplasms of the brain stem. Can Med Assoc J 98:1-71968 ... Julow JViola AMajor TValalik ISagi SMangel L: Iodine-125 brachytherapy of brain stem tumors. Strahlenther Onkol 180:449-4542004 ... Metastatic neoplasms of the brain stem. . Can Med Assoc J. 98. :. 1. -. 7. , 1968. ), false ... Shuto TFujino HAsada HInomori SNagano H: Gamma knife radiosurgery for metastatic tumours in the brain stem. Acta Neurochir ( ...
... maintain and gear stem cells towards re-activation. Cancer stem cells have been extensively studied in most malignancies, ... Cancer stem cells have been extensively studied in most malignancies, including glioma. Here, the aberrant niche activities ... different molecular mechanisms and properties of the neighboring cells can influence the molecular processes behind glioma stem ... different molecular mechanisms and properties of the neighboring cells can influence the molecular processes behind glioma stem ...
brain stem cancer. *malignant neoplasm of brain stem. diffuse midline glioma, h3 k27m-mutant. *diffuse intrinsic pontine glioma ... Diseases associated with H3C6 include Childhood Brain Stem Glioma and Brain Stem Cancer. Among its related pathways are ... aggressive gliomas including pediatric non-brain stem glioblastoma and diffuse intrinsic pontine glioma (DIPG) (PubMed:22286216 ... No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from ...
brain stem cancer. *malignant neoplasm of brain stem. - elite association - COSMIC cancer census association via MalaCards ... mRNA expression in embryonic tissues and stem cells from LifeMap Discovery. *span" data-trigger="SectionLoaded"> Eye (Sensory ... Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. ... Tissue specificity: Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their ...
Brain -- bone -- fat ... bone cysts, bone lumps, bone lumps*Brain Stem Neoplasms ... increased pressure inside skull*Branchial ... Cartilaginous neoplasms ... bone lump*Casanthranol -- Teratogenic Agent ... extra digits*Cat Eye Syndrome ... hip dislocation, ... Adrenal Cortex Neoplasms ... osteoporosis*Adrenal gland hyperfunction ... osteoporosis*Adrenal incidentaloma ... osteoporosis* ... Anencephaly ... absence of skull bone normally surrounding the brain*Aneurysmal bone cysts ... bone swelling, bone lump, bone ...
  • Today, there are conflicting data on the content of cancer stem cells responsible for recurrence and resistance to chemotherapy in tumors of human brain. (exp-oncology.com.ua)
  • The aim of the study was to analyze the content of CD133 + cells in different brain tumors by immunofluorescence assay and immunohistochemical method. (exp-oncology.com.ua)
  • The samples of different brain tumors removed during neurosurgical operations were studied for CD133 expression. (exp-oncology.com.ua)
  • In tumors of the brain of different genesis and degree of anaplasia CD133 + cells are found out. (exp-oncology.com.ua)
  • In malignant tumors (glioblastomas and medulloblastomas), CD133 + cells are much more frequently detected than in benign brain tumors. (exp-oncology.com.ua)
  • The content of CD133 + cells in brain tumors is highly variable being small and some malignant tumors, indicating low predictive and diagnostic value of cancer stem cell content in clinical practice. (exp-oncology.com.ua)
  • STCs of the brain tumors are characterized by unlimited capacity for self-renewal, the formation of tumors in experimental immunodeficient mouse, genetic damage and the generation of new tumor cells [6]. (exp-oncology.com.ua)
  • confirmed the possibility of the spontaneous transformation of CD133 + normal stem cells to STCs with a potential to produce invasive brain tumors in immunodeficient mice [9]. (exp-oncology.com.ua)
  • The most commonly used method is the determination of CD133 molecule (prominin-1) as a marker for many STCs identified to date in the tumors of brain, lung, liver, prostate, etc. [4, 12]. (exp-oncology.com.ua)
  • This multi-institutional study will prospectively collect tumor and constitutional tissue samples from patients with diffuse brainstem glioma and other types of brainstem gliomas either during therapy or at autopsy to perform an extensive analysis of genetic and molecular abnormalities in these tumors. (clinicaltrials.gov)
  • High grade diffuse intrinsic pontine glioma (DIPG) accounts for approximately 80% of pediatric brainstem tumors and 10% of pediatric brain tumors, and is the most lethal form of brainstem gliomas in children. (clinicaltrials.gov)
  • Brain tumors are among the most aggressive and intractable types of cancer. (nih.gov)
  • In light of these similarities, it has been suggested that brain tumors arise from stem cells, that they co-opt stem cell strategies for self-renewal, and even that they contain "cancer stem cells" that are critical for tumor maintenance. (nih.gov)
  • We will examine these possibilities and discuss their implications for the understanding and treatment of brain tumors. (nih.gov)
  • However, several properties of brain tumors add complexity to this model. (nih.gov)
  • In addition, these tumors recruit normal CNS stem and progenitor cells to the tumor mass leading to the possibility of a heterogeneous and polyclonal cell population. (nih.gov)
  • It is likely that a complete description of the role of stem cells in brain tumors will be more complex than our current models. (nih.gov)
  • However, concerns have been raised over the safety of this experimental therapeutic approach, including, for example, whether there is the potential for tumors to develop from transplanted stem cells. (nih.gov)
  • The authors review imaging and clinical outcomes in patients with metastatic brainstem tumors treated using Gamma Knife surgery (GKS). (thejns.org)
  • Pontine tumors are the most common variety of brainstem tumor. (medscape.com)
  • However, thalamic/hypothalamic neoplasms are not included historically in the classification of brainstem tumors. (medscape.com)
  • Taken together, these data validate the use of hSDSCs for targeting human brain tumors. (aacrjournals.org)
  • Brain tumors, such as glioblastoma multiforme, are highly aggressive tumors and are characterized by marked angiogenesis and extensive tumor cell invasion into the normal brain parenchyma ( 1 - 3 ). (aacrjournals.org)
  • In particular, my research has focused on the effective care of children through characterization of direct or surrogate imaging markers to improve understanding of physiologic and metabolic profiles of pediatric brain tumors at diagnosis and after therapy. (childrenshospital.org)
  • Brain tumors are the leading cause of cancer-related death in children but high-grade gliomas in children and adolescents have remained a relatively under-investigated disease despite this. (semanticscholar.org)
  • Preclinical Models of Pediatric Brain Tumors-Forging Ahead. (semanticscholar.org)
  • For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned. (icd10data.com)
  • Primary brain tumors appear to be relatively uncommon in most domestic species, however this is not the case in dogs and cats. (vin.com)
  • Most primary brain tumors are solitary, but multiple primary brain tumors have been reported. (vin.com)
  • Skull tumors may affect the brain by local extension. (vin.com)
  • Although brain tumors occur in dogs of all breeds, either sex and any age, the incidence increases over 5 years of age, and with certain breeds. (vin.com)
  • Secondary tumors reported to occur in the brain of cats include pituitary macroadenomas macrocarcinomas, and metastatic carcinomas. (vin.com)
  • Primary brain tumors originate from cells normally found within the brain and meninges, while secondary tumors are metastasis from a primary tumor located outside the nervous system, or by local invasion from adjacent non- neural tissues (e.g., bone). (vin.com)
  • Pituitary gland neoplasms and tumors arising from cranial nerves are considered secondary brain tumors. (vin.com)
  • Most cytologically malignant brain tumors are also biologically malignant, despite current treatments. (vin.com)
  • Cytologically benign brain tumors may be biologically malignant due to various secondary effects such as increased intracranial pressure (ICP). (vin.com)
  • Brain tumors cause cerebral dysfunction through infiltration of normal brain tissue, compression of adjacent structures, disruption of cerebral circulation and local necrosis. (vin.com)
  • Secondary effects of brain tumors include hydrocephalus, increased ICP, cerebral edema and brain herniation. (vin.com)
  • Primary brain tumors often are slow growing and the brain adapts to the slow increase in ICP. (vin.com)
  • Although brain tumors are classified and treated based upon their histology, the molecular factors involved in the development of various tumor types remain unknown. (uni-regensburg.de)
  • In this study, we show that the type and order of genetic events directs the development of gliomas, central nervous system primitive neuroectodermal tumors, and atypical teratoid/rhabdoid-like tumors from postnatal mouse neural stem/progenitor cells (NSC/NPC). (uni-regensburg.de)
  • We found that the overexpression of specific genes led to the development of these three different brain tumors from NSC/NPCs, and manipulation of the order of genetic events was able to convert one established tumor type into another. (uni-regensburg.de)
  • Taken together, our findings indicate that the order of genetic events determines the phenotypes of brain tumors derived from a common precursor cell pool, and suggest that the UPR may represent a therapeutic target in atypical teratoid/rhabdoid tumors. (uni-regensburg.de)
  • Dr. Cage has comprehensive neurosurgical training in treating traumatic brain injury, traumatic spine injury, degenerative and oncologic spine disorders, as well as extra-axial and intra-axial brain tumors. (stanford.edu)
  • The purpose of this clinical study is to confirm the utility of chemosensitivity tumor testing on cancer stem cells (ChemoID) as a predictor of clinical response in poor prognosis malignant brain tumors such as recurrent glioblastoma (GBM). (clinicaltrials.gov)
  • Nevertheless, the effectiveness of GKRS is much less known as concerns other unusual Low-Grade Primitive Neuroepithelial Tumors (LGPNTs) of the brain because data regarding the long-term efficacy of GKRS on a large series of patients with such tumors is lacking. (scribd.com)
  • They are the most common primary central nervous system tumors, representing about half of all primary brain and spinal cord tumors. (uamshealth.com)
  • One of the impediments to the treatment of brain tumors (e.g., gliomas) has been the degree to which they expand, infiltrate surrounding tissue, and migrate widely into normal brain, usually rendering them "elusive" to effective resection, irradiation, chemotherapy, or gene therapy. (pnas.org)
  • These data suggest the adjunctive use of inherently migratory NSCs as a delivery vehicle for targeting therapeutic genes and vectors to refractory, migratory, invasive brain tumors. (pnas.org)
  • Malignant brain tumors, e.g., glioblastoma multiforme, remain virtually untreatable and inevitably lethal despite extensive surgical excision and adjuvant radio- and chemotherapy ( 1 ). (pnas.org)
  • The latter may well include hypoxic-ischemic brain injury caused by recurrent respiratory infections and the direct (e.g., brain metastases) and possibly even paraneoplastic effects of tumors, making it impossible to determine precisely which lesions are the primary ones, i.e., caused exclusively by the direct effect of the A-T mutation in the brain. (pnas.org)
  • Within the umbrella of adult brainstem glioma, there is a subset of tumors that is similar in appearance and potentially similar in etiology to childhood DIPG, but with slightly older onset, generally affecting young adults. (frontiersin.org)
  • Brain stem glioma accounts for 6-9% of brain tumors in children. (cancerindex.org)
  • Glioma stem-like cells (GSCs) are undifferentiated and self-renewing cells that develop and maintain these tumors. (mdpi.com)
  • Here, we review current research associated with BMP4 in brain tumors, with an emphasis on pediatric malignant gliomas. (mdpi.com)
  • While chemo can be more effective in the rest of the body, the blood-brain barrier prevents the full force of chemotherapy from attacking intracranial tumors. (medgadget.com)
  • Brain tumors can be benign, with no cancer cells, or malignant, with cancer cells that grow quickly.brain tumors can cause many symptoms. (icd10data.com)
  • doctors diagnose brain tumors by doing a neurologic exam and tests including an mri, ct scan, and biopsy. (icd10data.com)
  • People with brain tumors have several treatment options. (icd10data.com)
  • In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain. (umassmed.edu)
  • An Update on the Approach to the Imaging of Brain Tumors. (umassmed.edu)
  • Classically, it has been associated with three major groups: Young patients with brain tumors in the pineal gland or midbrain: pinealoma (intracranial germinomas) are the most common lesion producing this syndrome. (wikipedia.org)
  • C71.7 is a billable ICD code used to specify a diagnosis of malignant neoplasm of brain stem. (icd.codes)
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. (icd10data.com)
  • A primary or metastatic malignant neoplasm affecting the brain. (icd10data.com)
  • Categories D37 - D44 , and D48 classify by site neoplasms of uncertain behavior, i.e., histologic confirmation whether the neoplasm is malignant or benign cannot be made. (icd10data.com)
  • The terms benign and malignant must be used carefullywhen referringto a brain neoplasm. (vin.com)
  • Although a canine meningioma may be classified as benign, it may be locally invasive and have poor demarcation from normal brain tissue. (vin.com)
  • Neoplasms show partial or complete lack of structural organization and functional coordination with the normal tissue, and usually form a distinct mass of tissue, which may be either benign (benign tumor) or malignant (cancer). (pituitary.org)
  • Therefore, acquisition of somatic mutations that drive clonal expansion in the absence of cytopenias and dysplastic hematopoiesis can be considered clonal hematopoiesis of indeterminate potential (CHIP), analogous to monoclonal gammopathy of undetermined significance and monoclonal B-cell lymphocytosis, which are precursor states for hematologic neoplasms but are usually benign and do not progress. (bloodjournal.org)
  • Primary neoplasms are subdivided into benign and malignant forms. (umassmed.edu)
  • Primary and metastatic neoplasms may occur in this location. (uchicago.edu)
  • Between March 1989 and March 2005, 53 patients (24 men and 29 women) with metastatic brainstem lesions underwent GKS. (thejns.org)
  • Thirty-four patients died of extracranial disease, three of the progressing metastatic brainstem lesion, and six of additional progressing intracranial deposits in other parts of the brain. (thejns.org)
  • Compared with allowing a metastatic brainstem lesion to take its natural course, GKS prolongs survival. (thejns.org)
  • A metastatic brain tumor starts somewhere else in the body and moves to the brain. (icd10data.com)
  • Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. (umassmed.edu)
  • 45%). The junction and peri-junctional areas between the brain stem and cerebellum appear to be the most vulnerable area by DAI, with the order of incidence SCP, ICP, and MCP. (biomedsearch.com)
  • Brain and Nervous System Cancer (incl. (healthgrades.com)
  • Cancer that has spread from the original (primary) tumor to the brain. (medindia.net)
  • One of the most devastating CNS pathologies is brain cancer. (nih.gov)
  • The undifferentiated character of brain tumor cells and recent reports of cancer stem cells prompt questions regarding the involvement of normal stem/progenitor cells in brain tumor biology, their potential contribution to the tumor itself, and whether they are the cause or the consequence of tumor initiation and progression. (nih.gov)
  • The cancer stem cell model proposes a clonally derived brain tumor arising from a cancer stem cell. (nih.gov)
  • The tumor cells differentiate unidirectionally from the cancer stem cell in a way parallel to normal development. (nih.gov)
  • Cancer patients (except patients with melanoma) with 1-6 brain metastases are randomized to receive standard whole brain radiation therapy or whole brain radiation therapy in a neural stem cell-preserving manner. (knowcancer.com)
  • Histologically confirmed non-melanoma primary malignancy with 1-6 intraparenchymal brain metastases (or small cell lung cancer being considered for prophylactic brain irradiation (PBI) with no demonstrable intracranial lesions). (knowcancer.com)
  • Cancer stem-like cells (CSCs) have been extensively studied in most malignancies, including glioma. (frontiersin.org)
  • Diseases associated with H3C6 include Childhood Brain Stem Glioma and Brain Stem Cancer . (genecards.org)
  • All-trans retinoic acid modulates cancer stem cells of glioblastoma multiforme in an MAPK-dependent manner. (semanticscholar.org)
  • Standard Chemotherapy Versus Chemotherapy Chosen by Cancer Stem Cell Chemosensitivity Testing in the Management of Patients With Recurrent Glioblastoma Multiforme (GBM). (clinicaltrials.gov)
  • The ChemoID test is a CLIA-certified and CAP-accredited drug response assay performed by a hospital clinical pathology laboratory that uses patient's live tumor cells to indicate which chemotherapy agent (or combinations) will kill not only bulk of tumor cells, but importantly the cancer stem cells (CSCs) that are known to cause cancer to recur. (clinicaltrials.gov)
  • During the assay, cancer stem cells and bulk tumor cells from an individual patient are exposed to FDA-approved chemotherapy drugs. (clinicaltrials.gov)
  • Stemline Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing novel oncology therapeutics that target both cancer stem cells (CSCs) as well as the tumor bulk. (cnbc.com)
  • Stemline's clinical candidates, SL-401 and SL-701, have demonstrated clinical activity, including durable complete responses (CRs), in Phase 1/2 studies of patients with advanced hematologic and brain cancer, respectively. (cnbc.com)
  • SL-701 is a subcutaneously-administered cancer vaccine comprised of multiple synthetic peptides corresponding to targets on tumor bulk and cancer stem cells (CSCs). (cnbc.com)
  • Cancer of the brain is usually called a brain tumor. (icd10data.com)
  • In this study, we undertook a series of experiments to investigate the tumor targeting capacity of human skin-derived stem cells (hSDSCs) in animal models of human glioblastoma. (aacrjournals.org)
  • SL-701 is being advanced into later stage trials of adults with second-line glioblastoma multiforme (GBM) and children with brainstem and non-brainstem glioma. (cnbc.com)
  • More broadly, they suggest that NSC migration can be extensive, even in the adult brain and along nonstereotypical routes, if pathology (as modeled here by tumor) is present. (pnas.org)
  • We hypothesized that pathology promotes NSC migration to an extent not assumed possible based on knowledge drawn from the normal adult brain and that, therefore, an approach for targeting gene therapy to the most migratory tumor cells in the adult central nervous system (CNS) might be the use of inherently migratory NSCs to deliver therapeutic genes and/or their products. (pnas.org)
  • Neither previous whole-brain radiation therapy nor a single brainstem metastasis was statistically related to the duration of survival. (thejns.org)
  • The tropism of NSCs for brain tumor can be used for delivering therapeutic molecules, such as genes, proteins, peptides, or small chemical molecules ( 13 , 14 ). (aacrjournals.org)
  • At the same time, recent large-scale sequencing studies have also revealed that acquisition of clonally restricted somatic mutations in MDS-associated genes in hematopoietic cells is not limited to individuals with MDS or related myeloid neoplasms. (bloodjournal.org)
  • Primary brain stem neoplasms are more frequent in children. (uchicago.edu)
  • Cerebral meningioma is the most frequently reported primary brain tumor of cats and accounts for almost 10% of all nonhematopoietic neoplasms. (vin.com)
  • INTRODUCTION: Traumatic brain injury (TBI) remains a primary cause of pediatric morbidity. (stanford.edu)
  • In addition, it is very likely that the neuropathology uncovered so far in A-T reflects a mixture of the primary neural insult plus its own progression, with an added component derived from protracted systemic complications that also cause brain alterations. (pnas.org)
  • Pediatric diffuse intrinsic pontine glioma (DIPG) - the most frequent malignant primary brain tumor of childhood - on the other hand, has been found to have substantially different biological underpinnings. (frontiersin.org)
  • In contrast to pediatric DIPG, which accounts for approximately 20% of pediatric primary brain neoplasms, adult brainstem glioma constitutes less than 2% of adult gliomas, with a slight male preponderance ( 3 , 4 ). (frontiersin.org)
  • A primary brain tumor starts in the brain. (icd10data.com)
  • A diagnostic contrast-enhanced magnetic resonance imaging (MRI) demonstrating the presence of 1-6 brain metastases performed within 4 weeks of registration. (knowcancer.com)
  • Increase in the Bi-dimensional Tumor Area for Any of the Tracked Brain Metastases or the Appearance of Any New Brain Metastases on a Follow-up MRI. (knowcancer.com)
  • The severity of systemic diseases largely determines the prognosis of metastases to the brainstem. (thejns.org)
  • These were implanted into mice with metastases in the brain. (medgadget.com)
  • Repeat Stereotactic Radiosurgery for Locally Recurrent Brain Metastases. (umassmed.edu)
  • Although usually a brain tumor, AT/RT can occur anywhere in the central nervous system (CNS) including the spinal cord. (icd.codes)
  • She also has completed a Neurotrauma fellowship at UCSF and San Francisco General Hospital with Geoff Manley, MD, PhD where she received specialized training in caring for patients after traumatic brain and spinal cord injuries. (stanford.edu)
  • The bottom-most portion of the brain connecting the cerebrum with the spinal cord. (uamshealth.com)
  • Pertaining to the brain, cranial nerves and spinal cord. (uamshealth.com)
  • The purpose of this study is to prospectively collect specimens from pediatric patients with diffuse intrinsic pontine glioma or brainstem glioma, either during therapy or at autopsy, in order to characterize the molecular abnormalities of this tumor. (clinicaltrials.gov)
  • The aim of this trial is to collect specimens from pediatric patients with diffuse intrinsic pontine glioma including serum, cerebrospinal fluid, urine, brain tumor and other constitutional tissue, during therapy and/or at autopsy. (clinicaltrials.gov)
  • Cerebrospinal fluid, serum, urine, brainstem tumor and constitutional tissue from patients with diffuse intrinsic pontine glioma or brainstem glioma will be collected. (clinicaltrials.gov)
  • The two-year survival for paediatric HGG ranges from 30%, for tumours arising in the cerebral cortex, to less than 10% for diffuse intrinsic pontine gliomas (DIPGs), which arise in the brainstem. (cancerindex.org)
  • Landolfi et al studied 19 adults with brainstem gliomas, which included 13 diffuse intrinsic pontine, 4 cervicomedullary, and 2 tectal gliomas. (medscape.com)
  • New experimental approaches have shown tumor regression after the grafting of neural stem cells and human mesenchymal stem cells into experimental intracranial gliomas of adult rodents. (aacrjournals.org)
  • Mesenchymal stem cells (MSC) can be easily isolated from the bone marrow ( 15 , 16 ) and migrate after local intracranial delivery to human gliomas ( 17 ). (aacrjournals.org)
  • Substantial displacement of brain parenchyma may cause elevation of intracranial pressure (ICP) and potentially fatal herniation syndromes. (wikipedia.org)
  • We demonstrate that neural stem cells (NSCs), when implanted into experimental intracranial gliomas in vivo in adult rodents, distribute themselves quickly and extensively throughout the tumor bed and migrate uniquely in juxtaposition to widely expanding and aggressively advancing tumor cells, while continuing to stably express a foreign gene. (pnas.org)
  • Intracranial neoplasms are notoriously difficult to kill. (medgadget.com)
  • Since very little is known about the biology of diffuse brainstem glioma, the goal of this protocol is to undertake a systematic analysis of DNA abnormalities, and of RNA and protein expression in prospectively collected fresh-frozen and fixed tumor samples and correspondent normal tissue from patients affected with this tumor. (clinicaltrials.gov)
  • Perform genome-wide analysis of DNA gains and losses and RNA expression in tumor samples and normal tissue from patients with diffuse brain stem glioma. (clinicaltrials.gov)
  • Confirm genomic gains or losses identified by means of fluorescence in situ hybridization (FISH) performed on tissue microarray using non-neoplastic brain tissue from each patient as control when available. (clinicaltrials.gov)
  • Explore protein expression patterns identified by immunohistochemistry or western blot and compare them to normal brain stem tissue. (clinicaltrials.gov)
  • We isolated recently and characterized a multipotent stem cells from human skin tissue expressing the CD133, a hemapoietic/endothelial marker ( 19 ). (aacrjournals.org)
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified ( C25.9 ). (icd10data.com)
  • Meningiomas in cats are almost always well defined with a clear demarcation between normal and affected brain tissue and appear to grow more slowly than canine meningiomas. (vin.com)
  • 2) high risk of permanent delayed brain tissue radiation damage in often very young patients and with long life expectancy. (scribd.com)
  • They often invade adjacent tissue and spread to distant organs, including the brain. (uamshealth.com)
  • Swelling of the brain tissue due to an accumulation of fluid which may be caused by tumor, toxic chemicals or interaction. (uamshealth.com)
  • Intracerebral hemorrhages and accompanying edema may disrupt or compress adjacent brain tissue, leading to neurological dysfunction. (wikipedia.org)
  • The findings here suggest that neuronal stem/progenitor cells may be involved in gliomagenesis and provide the first example of a donor-derived brain tumor. (nih.gov)
  • Kesari et al reported on 101 adult patients with brainstem glioma. (medscape.com)
  • Little is known about the endogenous mechanisms and molecules negatively regulating NSPC proliferation in the adult brain, which act to suppress the neurogenic response after stroke. (jneurosci.org)
  • have now extended the list of organisms with defined adult stem cell niches to include the golden star tunicate Botryllus schlosseri . (biologists.org)
  • This suggests that stem cell niches are highly conserved among species and illustrates the potential for this urochordate as a tractable model organism for defining the shared characteristics of adult stem cell niches. (biologists.org)
  • Steven Pollard and colleagues describe glioma stem cell culture on adult mouse brain slices to model tumour-host interactions. (biologists.org)
  • Because of these factors, our understanding of the biology of adult brainstem glioma is incomplete. (frontiersin.org)
  • Unfortunately, it is perhaps more apt to describe adult brainstem glioma as the valley shrouded in shadow between the two growing mountains of knowledge that represent adult glioma and pediatric DIPG, as few studies have investigated this particular diagnosis. (frontiersin.org)
  • The anatomical basis of adult brainstem glioma does not lend itself to easy study, as the brainstem is packed full of brainstem nuclei and white matter tracts that are essential for basic functions. (frontiersin.org)
  • The subset of adult brainstem gliomas presenting in later adulthood are typically more akin to other de novo malignant gliomas of adulthood. (frontiersin.org)
  • In this article, we will review the current state of knowledge (and lack of knowledge) for adult brainstem glioma and highlight prospects for advances in therapy. (frontiersin.org)
  • The dogma that the genesis of new cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of CNS tumours. (elsevier.com)
  • The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies. (elsevier.com)
  • Neuronal stem cells (NSCs), neuronal cells, precursors and differentiated glioma cells are considered as the sources of STCs. (exp-oncology.com.ua)
  • Neuronal neoplasms are rare in domestic animals ( KOESTNER & HIGGINS, 2002 ). (scielo.br)
  • Neural stem cells play a critical role in the production of neuronal cells in neurogenesis is of great importance. (meta.org)
  • DRG Group #054-055 - Nervous system neoplasms with MCC. (icd.codes)
  • Recently, transplanted neural stem cells (NSCs) have been recognized for their ability to migrate throughout the central nervous system ( 11 , 12 ). (aacrjournals.org)
  • The clinical picture suggested a posterior fossa neoplasm. (elsevier.com)
  • Neoplasms and giant aneurysms of the posterior fossa have also been associated with the midbrain syndrome. (wikipedia.org)
  • The limited available data suggest that adults fare better than children with brainstem gliomas. (medscape.com)
  • They identified 4 factors that were significantly associated with survival in adults with brainstem gliomas. (medscape.com)
  • however, the possibility of prolonged survival with limited neurologic impairment must be recognized when counseling adults with brainstem gliomas. (medscape.com)
  • Brainstem gliomas are not nearly as common in adults as they are in children. (frontiersin.org)
  • Malignant gliomas are heterogeneous neoplasms. (mdpi.com)
  • Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. (nih.gov)
  • This is the first report of a human brain tumor complicating neural stem cell therapy. (nih.gov)
  • Brain Stem Neoplasms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Bone Marrow Neoplasms are cancers that occur in the bone marrow. (meta.org)
  • Discover the latest research on Bone Marrow Neoplasms here. (meta.org)
  • A) Brain MRI (T2) demonstrating a lesion (arrow) based on the tentorium, next to the brain stem (BS). (nih.gov)
  • This review article covers the current knowledge regarding normal and aberrant cellular quiescence control whilst also exploring how different molecular mechanisms and properties of the neighboring cells can influence the molecular processes behind glioma stem cell quiescence. (frontiersin.org)
  • Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. (semanticscholar.org)
  • Poor prognostic indicators include (1) age younger than 2 years, (2) multiple brainstem signs, (3) cranial nerve palsies, (4) diffuse intrinsic lesions of the pons, (5) short duration of signs and symptoms prior to the time of diagnosis, and (6) high-grade histology on tumor biopsy. (medscape.com)
  • Hemorrhagic neoplasms are more complex, heterogeneous bleeds often with associated edema. (wikipedia.org)
  • Pilot Study for the Development of a Diagnostic Score to Differentiate Myeloproliferative Neoplasms. (bioportfolio.com)
  • Neoplasms involving the brain stem may result in cranial nerve deficits. (vin.com)
  • FAs may be asymptomatic or cause brain stem and cranial nerve compression, subarachnoid hemorrhage (SAH) or infarction. (scielo.br)
  • Pediatric brain tumor cell lines. (semanticscholar.org)
  • Her research has been recognized with the Lucien J. Rubenstein Memorial Award from the American Brain Tumor Association, the Young Investigator Award from the Pediatric Brain Tumor Foundation, and the Best Basic Science Research Paper Award from UCSF Neurological Surgery residency program. (stanford.edu)
  • Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium. (cancerindex.org)
  • Surgery involving the removal of skull bone to gain access to the brain. (uamshealth.com)
  • All patients had brain stem glioma not amenable to surgery. (cancerindex.org)
  • Peroperative cardiovascular stability during brainstem surgery. (meta.org)