The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Benign and malignant intra-axial tumors of the MESENCEPHALON; PONS; or MEDULLA OBLONGATA of the BRAIN STEM. Primary and metastatic neoplasms may occur in this location. Clinical features include ATAXIA, cranial neuropathies (see CRANIAL NERVE DISEASES), NAUSEA, hemiparesis (see HEMIPLEGIA), and quadriparesis. Primary brain stem neoplasms are more frequent in children. Histologic subtypes include GLIOMA; HEMANGIOBLASTOMA; GANGLIOGLIOMA; and EPENDYMOMA.
Electrical waves in the CEREBRAL CORTEX generated by BRAIN STEM structures in response to auditory click stimuli. These are found to be abnormal in many patients with CEREBELLOPONTINE ANGLE lesions, MULTIPLE SCLEROSIS, or other DEMYELINATING DISEASES.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Infarctions that occur in the BRAIN STEM which is comprised of the MIDBRAIN; PONS; and MEDULLA OBLONGATA. There are several named syndromes characterized by their distinctive clinical manifestations and specific sites of ischemic injury.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Parts of plants that usually grow vertically upwards towards the light and support the leaves, buds, and reproductive structures. (From Concise Dictionary of Biology, 1990)
Progenitor cells from which all blood cells derive.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Cells with high proliferative and self renewal capacities derived from adults.
Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Cells that can give rise to cells of the three different GERM LAYERS.
The front part of the hindbrain (RHOMBENCEPHALON) that lies between the MEDULLA and the midbrain (MESENCEPHALON) ventral to the cerebellum. It is composed of two parts, the dorsal and the ventral. The pons serves as a relay station for neural pathways between the CEREBELLUM to the CEREBRUM.
The lower portion of the BRAIN STEM. It is inferior to the PONS and anterior to the CEREBELLUM. Medulla oblongata serves as a relay station between the brain and the spinal cord, and contains centers for regulating respiratory, vasomotor, cardiac, and reflex activities.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
A particular zone of tissue composed of a specialized microenvironment where stem cells are retained in a undifferentiated, self-renewable state.
Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. Neural stem cells are precursors to both NEURONS and NEUROGLIA.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Cells from adult organisms that have been reprogrammed into a pluripotential state similar to that of EMBRYONIC STEM CELLS.
GRAY MATTER located in the dorsomedial part of the MEDULLA OBLONGATA associated with the solitary tract. The solitary nucleus receives inputs from most organ systems including the terminations of the facial, glossopharyngeal, and vagus nerves. It is a major coordinator of AUTONOMIC NERVOUS SYSTEM regulation of cardiovascular, respiratory, gustatory, gastrointestinal, and chemoreceptive aspects of HOMEOSTASIS. The solitary nucleus is also notable for the large number of NEUROTRANSMITTERS which are found therein.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
A circumscribed collection of purulent exudate in the brain, due to bacterial and other infections. The majority are caused by spread of infected material from a focus of suppuration elsewhere in the body, notably the PARANASAL SINUSES, middle ear (see EAR, MIDDLE); HEART (see also ENDOCARDITIS, BACTERIAL), and LUNG. Penetrating CRANIOCEREBRAL TRAUMA and NEUROSURGICAL PROCEDURES may also be associated with this condition. Clinical manifestations include HEADACHE; SEIZURES; focal neurologic deficits; and alterations of consciousness. (Adams et al., Principles of Neurology, 6th ed, pp712-6)
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Elements of limited time intervals, contributing to particular results or situations.
Part of the brain located in the MEDULLA OBLONGATA and PONS. It receives neural, chemical and hormonal signals, and controls the rate and depth of respiratory movements of the DIAPHRAGM and other respiratory muscles.
Refers to animals in the period of time just after birth.
A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.
Neural tracts connecting one part of the nervous system with another.
The 12th cranial nerve. The hypoglossal nerve originates in the hypoglossal nucleus of the medulla and supplies motor innervation to all of the muscles of the tongue except the palatoglossus (which is supplied by the vagus). This nerve also contains proprioceptive afferents from the tongue muscles.
A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis and is a growth factor for a number of cell types including the MAST CELLS and the MELANOCYTES in addition to the HEMATOPOIETIC STEM CELLS.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
A region extending from the PONS & MEDULLA OBLONGATA through the MESENCEPHALON, characterized by a diversity of neurons of various sizes and shapes, arranged in different aggregations and enmeshed in a complicated fiber network.
Multi-channel hearing devices typically used for patients who have tumors on the COCHLEAR NERVE and are unable to benefit from COCHLEAR IMPLANTS after tumor surgery that severs the cochlear nerve. The device electrically stimulates the nerves of cochlea nucleus in the BRAIN STEM rather than the inner ear as in cochlear implants.
A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
C57BL mice are a commonly used strain of laboratory mice that are inbred to produce consistent and predictable results in scientific research.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Nerve tissue proteins are the structural and functional components of neurons and glial cells that make up the nervous system.
Nuclei of the trigeminal nerve situated in the brain stem. They include the nucleus of the spinal trigeminal tract (TRIGEMINAL NUCLEUS, SPINAL), the principal sensory nucleus, the mesencephalic nucleus, and the motor nucleus.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
Use of electric potential or currents to elicit biological responses.
The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Cells derived from a FETUS that retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A condition characterized by abnormal posturing of the limbs that is associated with injury to the brainstem. This may occur as a clinical manifestation or induced experimentally in animals. The extensor reflexes are exaggerated leading to rigid extension of the limbs accompanied by hyperreflexia and opisthotonus. This condition is usually caused by lesions which occur in the region of the brainstem that lies between the red nuclei and the vestibular nuclei. In contrast, decorticate rigidity is characterized by flexion of the elbows and wrists with extension of the legs and feet. The causative lesion for this condition is located above the red nuclei and usually consists of diffuse cerebral damage. (From Adams et al., Principles of Neurology, 6th ed, p358)
The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).
The circulation of blood through the BLOOD VESSELS of the BRAIN.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Experimentation on STEM CELLS and on the use of stem cells.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The dorsal portion or roof of the midbrain which is composed of two pairs of bumps, the INFERIOR COLLICULI and the SUPERIOR COLLICULI. These four colliculi are also called the quadrigeminal bodies (TECTUM MESENCEPHALI). They are centers for visual sensorimotor integration.
The middle of the three primitive cerebral vesicles of the embryonic brain. Without further subdivision, midbrain develops into a short, constricted portion connecting the PONS and the DIENCEPHALON. Midbrain contains two major parts, the dorsal TECTUM MESENCEPHALI and the ventral TEGMENTUM MESENCEPHALI, housing components of auditory, visual, and other sensorimoter systems.
Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.
Nerve structures through which impulses are conducted from a nerve center toward a peripheral site. Such impulses are conducted via efferent neurons (NEURONS, EFFERENT), such as MOTOR NEURONS, autonomic neurons, and hypophyseal neurons.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges.
Portion of midbrain situated under the dorsal TECTUM MESENCEPHALI. The two ventrolateral cylindrical masses or peduncles are large nerve fiber bundles providing a tract of passage between the FOREBRAIN with the HINDBRAIN. Ventral MIDBRAIN also contains three colorful structures: the GRAY MATTER (PERIAQUEDUCTAL GRAY), the black substance (SUBSTANTIA NIGRA), and the RED NUCLEUS.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Bleeding into structures of BRAIN STEM, including the MIDBRAIN; PONS; or MEDULLA OBLONGATA, as the result of CRANIOCEREBRAL TRAUMA. DIFFUSE AXONAL INJURY is commonly associated. Clinical manifestations may include OCULAR MOTILITY DISORDERS; ATAXIA; PARALYSIS; PERSISTENT VEGETATIVE STATE; and COMA.
Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.
Nucleus of the spinal tract of the trigeminal nerve. It is divided cytoarchitectonically into three parts: oralis, caudalis (TRIGEMINAL CAUDAL NUCLEUS), and interpolaris.
The time from the onset of a stimulus until a response is observed.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS.
A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.
Paired bodies containing mostly GRAY MATTER and forming part of the lateral wall of the THIRD VENTRICLE of the brain.
The human being as a non-anatomical and non-zoological entity. The emphasis is on the philosophical or artistic treatment of the human being, and includes lay and social attitudes toward the body in history. (From J. Cassedy, NLM History of Medicine Division)
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Therapy for MOVEMENT DISORDERS, especially PARKINSON DISEASE, that applies electricity via stereotactic implantation of ELECTRODES in specific areas of the BRAIN such as the THALAMUS. The electrodes are attached to a neurostimulator placed subcutaneously.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
One of three principal openings in the SUBARACHNOID SPACE. They are also known as cerebellomedullary cistern, and collectively as cisterns.
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.
The 6th cranial nerve which originates in the ABDUCENS NUCLEUS of the PONS and sends motor fibers to the lateral rectus muscles of the EYE. Damage to the nerve or its nucleus disrupts horizontal eye movement control.
Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.
NEURAL PATHWAYS and connections within the CENTRAL NERVOUS SYSTEM, beginning at the hair cells of the ORGAN OF CORTI, continuing along the eighth cranial nerve, and terminating at the AUDITORY CORTEX.
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.
The observable response an animal makes to any situation.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Neurons which activate MUSCLE CELLS.
The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Twelve pairs of nerves that carry general afferent, visceral afferent, special afferent, somatic efferent, and autonomic efferent fibers.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes.
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
An acute or subacute inflammatory process of the CENTRAL NERVOUS SYSTEM characterized histologically by multiple foci of perivascular demyelination. Symptom onset usually occurs several days after an acute viral infection or immunization, but it may coincide with the onset of infection or rarely no antecedent event can be identified. Clinical manifestations include CONFUSION, somnolence, FEVER, nuchal rigidity, and involuntary movements. The illness may progress to COMA and eventually be fatal. (Adams et al., Principles of Neurology, 6th ed, p921)
Common name for the only family (Petromyzontidae) of eellike fish in the order Petromyzontiformes. They are jawless but have a sucking mouth with horny teeth.
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A form of electrophysiologic audiometry in which an analog computer is included in the circuit to average out ongoing or spontaneous brain wave activity. A characteristic pattern of response to a sound stimulus may then become evident. Evoked response audiometry is known also as electric response audiometry.
A part of the MEDULLA OBLONGATA situated in the olivary body. It is involved with motor control and is a major source of sensory input to the CEREBELLUM.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
Techniques used mostly during brain surgery which use a system of three-dimensional coordinates to locate the site to be operated on.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.
A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Formation of NEURONS which involves the differentiation and division of STEM CELLS in which one or both of the daughter cells become neurons.
A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.
The physiological renewal, repair, or replacement of tissue.
The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.
The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
Surgical insertion of an electronic hearing device (AUDITORY BRAIN STEM IMPLANTS) with electrodes to the cochlea nucleus in the BRAIN STEM rather than to the inner ear as in COCHLEAR IMPLANTATION.
The space between the arachnoid membrane and PIA MATER, filled with CEREBROSPINAL FLUID. It contains large blood vessels that supply the BRAIN and SPINAL CORD.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Localized or diffuse reduction in blood flow through the vertebrobasilar arterial system, which supplies the BRAIN STEM; CEREBELLUM; OCCIPITAL LOBE; medial TEMPORAL LOBE; and THALAMUS. Characteristic clinical features include SYNCOPE; lightheadedness; visual disturbances; and VERTIGO. BRAIN STEM INFARCTIONS or other BRAIN INFARCTION may be associated.
Collections of small neurons centrally scattered among many fibers from the level of the TROCHLEAR NUCLEUS in the midbrain to the hypoglossal area in the MEDULLA OBLONGATA.
Established cell cultures that have the potential to propagate indefinitely.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Wave-like oscillations of electric potential between parts of the brain recorded by EEG.
The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.
The anterior subdivision of the embryonic PROSENCEPHALON or the corresponding part of the adult prosencephalon that includes the cerebrum and associated structures.
An octamer transcription factor that is expressed primarily in totipotent embryonic STEM CELLS and GERM CELLS and is down-regulated during CELL DIFFERENTIATION.
The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)
Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
Cells specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptor cells may monitor external stimuli, as in TASTE and OLFACTION, or internal stimuli, such as the concentrations of OXYGEN and CARBON DIOXIDE in the blood.
The electric response evoked in the CEREBRAL CORTEX by stimulation along AFFERENT PATHWAYS from PERIPHERAL NERVES to CEREBRUM.
An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.
The most common inhibitory neurotransmitter in the central nervous system.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
The anterior of the three primitive cerebral vesicles of the embryonic brain arising from the NEURAL TUBE. It subdivides to form DIENCEPHALON and TELENCEPHALON. (Stedmans Medical Dictionary, 27th ed)
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
The infratentorial compartment that contains the CEREBELLUM and BRAIN STEM. It is formed by the posterior third of the superior surface of the body of the sphenoid (SPHENOID BONE), by the occipital, the petrous, and mastoid portions of the TEMPORAL BONE, and the posterior inferior angle of the PARIETAL BONE.
Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.
The cochlear part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The cochlear nerve fibers originate from neurons of the SPIRAL GANGLION and project peripherally to cochlear hair cells and centrally to the cochlear nuclei (COCHLEAR NUCLEUS) of the BRAIN STEM. They mediate the sense of hearing.
The four cellular masses in the floor of the fourth ventricle giving rise to a widely dispersed special sensory system. Included is the superior, medial, inferior, and LATERAL VESTIBULAR NUCLEUS. (From Dorland, 27th ed)
An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
The 8th cranial nerve. The vestibulocochlear nerve has a cochlear part (COCHLEAR NERVE) which is concerned with hearing and a vestibular part (VESTIBULAR NERVE) which mediates the sense of balance and head position. The fibers of the cochlear nerve originate from neurons of the SPIRAL GANGLION and project to the cochlear nuclei (COCHLEAR NUCLEUS). The fibers of the vestibular nerve arise from neurons of Scarpa's ganglion and project to the VESTIBULAR NUCLEI.
Cell separation is the process of isolating specific cells from a mixture of cells, often for the purpose of further study or treatment.
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
A transient absence of spontaneous respiration.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The brain stem nucleus that receives the central input from the cochlear nerve. The cochlear nucleus is located lateral and dorsolateral to the inferior cerebellar peduncles and is functionally divided into dorsal and ventral parts. It is tonotopically organized, performs the first stage of central auditory processing, and projects (directly or indirectly) to higher auditory areas including the superior olivary nuclei, the medial geniculi, the inferior colliculi, and the auditory cortex.
Any operation on the cranium or incision into the cranium. (Dorland, 28th ed)
Relatively complete absence of oxygen in one or more tissues.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Single cells that have the potential to form an entire organism. They have the capacity to specialize into extraembryonic membranes and tissues, the embryo, and all postembryonic tissues and organs. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)
Rhodanine is a heterocyclic compound with potential medicinal applications, including as a chelating agent for heavy metals and as an anti-inflammatory.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
The decrease in neuronal activity (related to a decrease in metabolic demand) extending from the site of cortical stimulation. It is believed to be responsible for the decrease in cerebral blood flow that accompanies the aura of MIGRAINE WITH AURA. (Campbell's Psychiatric Dictionary, 8th ed.)
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Depolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during neurotransmission. Excitatory postsynaptic potentials can singly or in summation reach the trigger threshold for ACTION POTENTIALS.
An irregularly shaped cavity in the RHOMBENCEPHALON, located between the MEDULLA OBLONGATA; the PONS; and the isthmus in front, and the CEREBELLUM behind. It is continuous with the central canal of the cord below and with the CEREBRAL AQUEDUCT above, and through its lateral and median apertures it communicates with the SUBARACHNOID SPACE.
Any of various diseases affecting the white matter of the central nervous system.
Any operation on the spinal cord. (Stedman, 26th ed)
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A type VI intermediate filament protein expressed mostly in nerve cells where it is associated with the survival, renewal and mitogen-stimulated proliferation of neural progenitor cells.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
Conditions characterized by persistent brain damage or dysfunction as sequelae of cranial trauma. This disorder may result from DIFFUSE AXONAL INJURY; INTRACRANIAL HEMORRHAGES; BRAIN EDEMA; and other conditions. Clinical features may include DEMENTIA; focal neurologic deficits; PERSISTENT VEGETATIVE STATE; AKINETIC MUTISM; or COMA.

FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. (1/3138)

Beads containing recombinant FGF8 (FGF8-beads) were implanted in the prospective caudal diencephalon or midbrain of chick embryos at stages 9-12. This induced the neuroepithelium rostral and caudal to the FGF8-bead to form two ectopic, mirror-image midbrains. Furthermore, cells in direct contact with the bead formed an outgrowth that protruded laterally from the neural tube. Tissue within such lateral outgrowths developed proximally into isthmic nuclei and distally into a cerebellum-like structure. These morphogenetic effects were apparently due to FGF8-mediated changes in gene expression in the vicinity of the bead, including a repressive effect on Otx2 and an inductive effect on En1, Fgf8 and Wnt1 expression. The ectopic Fgf8 and Wnt1 expression domains formed nearly complete concentric rings around the FGF8-bead, with the Wnt1 ring outermost. These observations suggest that FGF8 induces the formation of a ring-like ectopic signaling center (organizer) in the lateral wall of the brain, similar to the one that normally encircles the neural tube at the isthmic constriction, which is located at the boundary between the prospective midbrain and hindbrain. This ectopic isthmic organizer apparently sends long-range patterning signals both rostrally and caudally, resulting in the development of the two ectopic midbrains. Interestingly, our data suggest that these inductive signals spread readily in a caudal direction, but are inhibited from spreading rostrally across diencephalic neuromere boundaries. These results provide insights into the mechanism by which FGF8 induces an ectopic organizer and suggest that a negative feedback loop between Fgf8 and Otx2 plays a key role in patterning the midbrain and anterior hindbrain.  (+info)

Characterization of an amphioxus paired box gene, AmphiPax2/5/8: developmental expression patterns in optic support cells, nephridium, thyroid-like structures and pharyngeal gill slits, but not in the midbrain-hindbrain boundary region. (2/3138)

On the basis of developmental gene expression, the vertebrate central nervous system comprises: a forebrain plus anterior midbrain, a midbrain-hindbrain boundary region (MHB) having organizer properties, and a rhombospinal domain. The vertebrate MHB is characterized by position, by organizer properties and by being the early site of action of Wnt1 and engrailed genes, and of genes of the Pax2/5/8 subfamily. Wada and others (Wada, H., Saiga, H., Satoh, N. and Holland, P. W. H. (1998) Development 125, 1113-1122) suggested that ascidian tunicates have a vertebrate-like MHB on the basis of ascidian Pax258 expression there. In another invertebrate chordate, amphioxus, comparable gene expression evidence for a vertebrate-like MHB is lacking. We, therefore, isolated and characterized AmphiPax2/5/8, the sole member of this subfamily in amphioxus. AmphiPax2/5/8 is initially expressed well back in the rhombospinal domain and not where a MHB would be expected. In contrast, most of the other expression domains of AmphiPax2/5/8 correspond to expression domains of vertebrate Pax2, Pax5 and Pax8 in structures that are probably homologous - support cells of the eye, nephridium, thyroid-like structures and pharyngeal gill slits; although AmphiPax2/5/8 is not transcribed in any structures that could be interpreted as homologues of vertebrate otic placodes or otic vesicles. In sum, the developmental expression of AmphiPax2/5/8 indicates that the amphioxus central nervous system lacks a MHB resembling the vertebrate isthmic region. Additional gene expression data for the developing ascidian and amphioxus nervous systems would help determine whether a MHB is a basal chordate character secondarily lost in amphioxus. The alternative is that the MHB is a vertebrate innovation.  (+info)

Angiotensin II type 1 receptor-mediated inhibition of K+ channel subunit kv2.2 in brain stem and hypothalamic neurons. (3/3138)

Angiotensin II (Ang II) has powerful modulatory actions on cardiovascular function that are mediated by specific receptors located on neurons within the hypothalamus and brain stem. Incubation of neuronal cocultures of rat hypothalamus and brain stem with Ang II elicits an Ang II type 1 (AT1) receptor-mediated inhibition of total outward K+ current that contributes to an increase in neuronal firing rate. However, the exact K+ conductance(s) that is inhibited by Ang II are not established. Pharmacological manipulation of total neuronal outward K+ current revealed a component of K+ current sensitive to quinine, tetraethylammonium, and 4-aminopyridine, with IC50 values of 21.7 micromol/L, 1.49 mmol/L, and 890 micromol/L, respectively, and insensitive to alpha-dendrotoxin (100 to 500 nmol/L), charybdotoxin (100 to 500 nmol/L), and mast cell degranulating peptide (1 micromol/L). Collectively, these data suggest the presence of Kv2.2 and Kv3.1b. Biophysical examination of the quinine-sensitive neuronal K+ current demonstrated a macroscopic conductance with similar biophysical properties to those of Kv2.2 and Kv3.1b. Ang II (100 nmol/L), in the presence of the AT2 receptor blocker PD123,319, elicited an inhibition of neuronal K+ current that was abolished by quinine (50 micromol/L). Reverse transcriptase-polymerase chain reaction analysis confirmed the presence of Kv2.2 and Kv3.1b mRNA in these neurons. However, Western blot analyses demonstrated that only Kv2.2 protein was present. Coexpression of Kv2.2 and the AT1 receptor in Xenopus oocytes demonstrated an Ang II-induced inhibition of Kv2.2 current. Therefore, these data suggest that inhibition of Kv2.2 contributes to the AT1 receptor-mediated reduction of neuronal K+ current and subsequently to the modulation of cardiovascular function.  (+info)

The superior olivary nucleus and its influence on nucleus laminaris: a source of inhibitory feedback for coincidence detection in the avian auditory brainstem. (4/3138)

Located in the ventrolateral region of the avian brainstem, the superior olivary nucleus (SON) receives inputs from nucleus angularis (NA) and nucleus laminaris (NL) and projects back to NA, NL, and nucleus magnocellularis (NM). The reciprocal connections between the SON and NL are of particular interest because they constitute a feedback circuit for coincidence detection. In the present study, the chick SON was investigated. In vivo tracing studies show that the SON projects predominantly to the ipsilateral NM, NL, and NA. In vitro whole-cell recording reveals single-cell morphology, firing properties, and postsynaptic responses. SON neurons are morphologically and physiologically suited for temporal integration; their firing patterns do not reflect the temporal structure of their excitatory inputs. Of most interest, direct stimulation of the SON evokes long-lasting inhibition in NL neurons. The inhibition blocks both intrinsic spike generation and orthodromically evoked activity in NL neurons and can be eliminated by bicuculline methiodide, a potent antagonist for GABAA receptor-mediated neurotransmission. These results strongly suggest that the SON provides GABAergic inhibitory feedback to laminaris neurons. We discuss a mechanism whereby SON-evoked GABAergic inhibition can influence the coding of interaural time differences for sound localization in the avian auditory brainstem.  (+info)

Concurrent inhibition and excitation of phrenic motoneurons during inspiration: phase-specific control of excitability. (5/3138)

The movements that define behavior are controlled by motoneuron output, which depends on the excitability of motoneurons and the synaptic inputs they receive. Modulation of motoneuron excitability takes place over many time scales. To determine whether motoneuron excitability is specifically modulated during the active versus the quiescent phase of rhythmic behavior, we compared the input-output properties of phrenic motoneurons (PMNs) during inspiratory and expiratory phases of respiration. In neonatal rat brainstem-spinal cord preparations that generate rhythmic respiratory motor outflow, we blocked excitatory inspiratory synaptic drive to PMNs and then examined their phase-dependent responses to superthreshold current pulses. Pulses during inspiration elicited fewer action potentials compared with identical pulses during expiration. This reduced excitability arose from an inspiratory-phase inhibitory input that hyperpolarized PMNs in the absence of excitatory inspiratory inputs. Local application of bicuculline blocked this inhibition as well as the difference between inspiratory and expiratory firing. Correspondingly, bicuculline locally applied to the midcervical spinal cord enhanced fourth cervical nerve (C4) inspiratory burst amplitude. Strychnine had no effect on C4 output. Nicotinic receptor antagonists neither potentiated C4 output nor blocked its potentiation by bicuculline, further indicating that the inhibition is not from recurrent inhibitory pathways. We conclude that it is bulbospinal in origin. These data demonstrate that rapid changes in motoneuron excitability occur during behavior and suggest that integration of overlapping, opposing synaptic inputs to motoneurons is important in controlling motor outflow. Modulation of phasic inhibition may represent a means for regulating the transfer function of PMNs to suit behavioral demands.  (+info)

A clinical study of motor evoked potentials using a triple stimulation technique. (6/3138)

Amplitudes of motor evoked potentials (MEPs) are usually much smaller than those of motor responses to maximal peripheral nerve stimulation, and show marked variation between normal subjects and from one stimulus to another. Consequently, amplitude measurements have low sensitivity to detect central motor conduction failures due to the broad range of normal values. Since these characteristics are mostly due to varying desynchronization of the descending action potentials, causing different degrees of phase cancellation, we applied the recently developed triple stimulation technique (TST) to study corticospinal conduction to 489 abductor digiti minimi muscles of 271 unselected patients referred for possible corticospinal dysfunction. The TST allows resynchronization of the MEP, and thereby a quantification of the proportion of motor units activated by the transcranial stimulus. TST results were compared with those of conventional MEPs. In 212 of 489 sides, abnormal TST responses suggested conduction failure of various degrees. By contrast, conventional MEPs detected conduction failures in only 77 of 489 sides. The TST was therefore 2.75 times more sensitive than conventional MEPs in disclosing corticospinal conduction failures. When the results of the TST and conventional MEPs were combined, 225 sides were abnormal: 145 sides showed central conduction failure, 13 sides central conduction slowing and 67 sides both conduction failure and slowing. It is concluded that the TST is a valuable addition to the study of MEPs, since it improves detection and gives quantitative information on central conduction failure, an abnormality which appears to be much more frequent than conduction slowing. This new technique will be useful in following the natural course and the benefit of treatments in disorders affecting central motor conduction.  (+info)

Infratentorial atrophy on magnetic resonance imaging and disability in multiple sclerosis. (7/3138)

Loss of tissue volume in the central nervous system may provide an index of fixed neurological dysfunction in multiple sclerosis. Recent magnetic resonance studies have shown a modest relationship between clinical disability rating scores and transverse sectional area of the cervical spinal cord. To explore further the relationship between atrophy and disability in multiple sclerosis, we estimated the volumes of infratentorial structures from MRIs in a cross-sectional study of 41 patients, 21 with relapsing-remitting multiple sclerosis and 20 with secondary progressive multiple sclerosis. We used the Cavalieri method of modern design stereology with point counting to estimate the volume of brainstem, cerebellum and upper cervical spinal cord from three-dimensional MRIs acquired with an MPRAGE (Magnetization-prepared Rapid Acquisition Gradient Echo) sequence. The volume of the upper (C1-C3) cervical spinal cord was significantly correlated with a composite spinal cord score derived from the appropriate Functional Scale scores of the Expanded Disability Status Scale (r = -0.50, P < 0.01). The cerebellar (r = 0.49, P < 0.01) and brainstem (r = 0.34, P < 0.05) volumes correlated with the Scripp's Neurological Disability Rating Scale scores. The upper cervical cord volumes (r = -0.39, P < 0.01), but not the brainstem or cerebellar volumes, were significantly associated with disease duration. MRI-estimated structural volumes may provide a simple index of axonal and/or myelin loss, the presumed pathological substrates of irreversible impairment and disability in multiple sclerosis.  (+info)

Tissue-specific changes of type 1 angiotensin II receptor and angiotensin-converting enzyme mRNA in angiotensinogen gene-knockout mice. (8/3138)

This study examined whether type 1 angiotensin II receptor (AT1) and angiotensin-converting enzyme (ACE) mRNAs are regulated during dietary salt loading in angiotensinogen gene-knockout (Atg-/-) mice which are genetically deficient in endogenous production of angiotensin II. Wild-type (Atg+/+) and Atg-/- mice were fed a normal-salt (0.3% NaCl) or a high-salt (4% NaCl) diet for 2 weeks. The mRNA levels were measured by Northern blot analysis. In Atg+/+ mice, concentrations of plasma angiotensin peptides were decreased by salt loading, whereas the treatment increased the brainstem, cardiac, pulmonary, renal cortex, gastric and intestinal AT1 mRNA levels. Salt loading also enhanced renal cortex ACE mRNA levels in Atg+/+ mice. Although plasma angiotensin peptides and urinary aldosterone excretion were not detected in Atg-/- mice, salt loading increased blood pressure in Atg-/- mice. In Atg-/- mice, pulmonary, renal cortex, gastric and intestinal AT1, and renal cortex and intestinal ACE mRNA levels were higher than those in Atg+/+ mice. However, salt loading upregulated AT1 mRNA expression only in the liver of Atg-/- mice, and the treatment did not affect ACE mRNA levels in Atg-/- mice. Furthermore, although the levels of ACE enzymatic activity showed the same trend with the ACE mRNA levels in the lung, renal cortex and intestine of both Atg-/- and Atg+/+ mice, the results of radioligand binding assay showed that cardiac expression of AT1 protein was regulated differently from AT1 mRNA expression both in Atg-/- and Atg+/+ mice. Thus, expression of AT1 and ACE is regulated by salt loading in a tissue-specific manner that appears to be mediated, at least partly, by a mechanism other than changes in the circulating or tissue levels of angiotensin peptides.  (+info)

The brainstem is the lower part of the brain that connects the brain to the spinal cord. It is responsible for controlling many of the body's essential functions, including breathing, heart rate, blood pressure, and sleep. The brainstem consists of three main parts: the midbrain, pons, and medulla oblongata. These structures are responsible for regulating many different bodily functions, including sensory perception, motor control, and autonomic functions such as heart rate and breathing. Damage to the brainstem can result in a range of symptoms, including difficulty breathing, changes in heart rate, and loss of consciousness.

Brain chemistry refers to the chemical processes that occur within the brain, including the production, release, and regulation of neurotransmitters, hormones, and other chemical messengers. These chemical processes play a critical role in regulating mood, behavior, cognition, and other aspects of brain function. In the medical field, brain chemistry is often studied in the context of neurological and psychiatric disorders, such as depression, anxiety, schizophrenia, and addiction. By understanding the underlying chemical imbalances or abnormalities in the brain, researchers and healthcare providers can develop more effective treatments for these conditions. Some common neurotransmitters and hormones involved in brain chemistry include dopamine, serotonin, norepinephrine, acetylcholine, and cortisol. Medications such as antidepressants, antipsychotics, and mood stabilizers often work by altering the levels of these chemicals in the brain to improve symptoms of various disorders.

Brain injuries refer to any type of damage or trauma that affects the brain, which is the most complex and vital organ in the human body. Brain injuries can be caused by a variety of factors, including physical trauma, such as a blow to the head, exposure to toxins, infections, or degenerative diseases. Brain injuries can range from mild to severe and can affect different parts of the brain, leading to a wide range of symptoms and complications. Some common types of brain injuries include concussion, contusion, hematoma, edema, and traumatic brain injury (TBI). Symptoms of brain injuries can vary depending on the severity and location of the injury, but may include headache, dizziness, nausea, vomiting, confusion, memory loss, difficulty speaking or understanding speech, changes in behavior or personality, seizures, and loss of consciousness. Treatment for brain injuries depends on the severity and type of injury, and may include medications, surgery, physical therapy, occupational therapy, and speech therapy. In some cases, rehabilitation may be necessary to help individuals recover from the effects of a brain injury and regain their ability to function in daily life.

Brain neoplasms, also known as brain tumors, are abnormal growths of cells in the brain. They can be either benign (non-cancerous) or malignant (cancerous). Brain tumors can occur in any part of the brain and can be primary (originating from brain cells) or secondary (spreading from other parts of the body to the brain). Symptoms of brain neoplasms can vary depending on the location and size of the tumor, but may include headaches, seizures, changes in vision or hearing, difficulty with balance or coordination, and changes in personality or behavior. Diagnosis of brain neoplasms typically involves a combination of imaging tests such as MRI or CT scans, as well as a biopsy to confirm the presence of cancer cells. Treatment options for brain neoplasms may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. The specific treatment plan will depend on the type, location, and stage of the tumor, as well as the overall health of the patient.

Brain stem neoplasms refer to tumors that develop in the brain stem, which is the part of the brain that connects the spinal cord to the rest of the brain. The brain stem is responsible for controlling vital functions such as breathing, heart rate, and blood pressure, and it also plays a role in regulating consciousness and movement. Brain stem neoplasms can be either benign (non-cancerous) or malignant (cancerous). Benign brain stem tumors are less common than malignant tumors, but they can still cause significant symptoms and complications. Malignant brain stem tumors are more aggressive and can spread to other parts of the brain and body. Symptoms of brain stem neoplasms can vary depending on the location and size of the tumor, but they may include headache, nausea, vomiting, dizziness, weakness or numbness in the face, arms, or legs, difficulty speaking or swallowing, and changes in vision or hearing. Diagnosis typically involves a combination of imaging tests such as MRI or CT scans, as well as a biopsy to confirm the presence of a tumor. Treatment for brain stem neoplasms may include surgery, radiation therapy, chemotherapy, or a combination of these approaches. The goal of treatment is to remove or shrink the tumor, relieve symptoms, and improve quality of life. However, because the brain stem is a critical part of the brain, treatment for these tumors can be complex and may carry risks and complications.

Brain mapping is a technique used in the medical field to create detailed images of the structure and function of the brain. It involves the use of various imaging technologies, such as magnetic resonance imaging (MRI), positron emission tomography (PET), and functional magnetic resonance imaging (fMRI), to create three-dimensional maps of the brain's anatomy and activity. The goal of brain mapping is to identify the specific areas of the brain that are responsible for different functions, such as movement, sensation, language, and emotion. By understanding how different parts of the brain work together, researchers and clinicians can better diagnose and treat a wide range of neurological and psychiatric disorders, including stroke, epilepsy, Alzheimer's disease, and depression. Brain mapping can also be used to study the effects of drugs, surgery, and other interventions on brain function, and to develop new treatments for neurological and psychiatric conditions. Overall, brain mapping is an important tool in the field of neuroscience, helping researchers and clinicians to better understand the complex workings of the human brain.

Brain stem infarctions refer to the blockage or occlusion of blood vessels in the brain stem, which is the lower part of the brain that connects the brain to the spinal cord. This can result in the death of brain cells in the affected area, leading to a range of symptoms and complications. The brain stem is responsible for controlling vital functions such as breathing, heart rate, blood pressure, and swallowing. As a result, brain stem infarctions can cause a range of symptoms, including difficulty speaking or understanding speech, difficulty swallowing, loss of balance or coordination, double vision, and changes in consciousness or alertness. Brain stem infarctions can be caused by a variety of factors, including high blood pressure, diabetes, high cholesterol, smoking, and atherosclerosis (the hardening and narrowing of arteries). Treatment typically involves managing the underlying cause of the infarction, as well as addressing any symptoms or complications that may arise. In some cases, rehabilitation may also be necessary to help individuals recover from the effects of a brain stem infarction.

In the medical field, the brain is the most complex and vital organ in the human body. It is responsible for controlling and coordinating all bodily functions, including movement, sensation, thought, emotion, and memory. The brain is located in the skull and is protected by the skull bones and cerebrospinal fluid. The brain is composed of billions of nerve cells, or neurons, which communicate with each other through electrical and chemical signals. These neurons are organized into different regions of the brain, each with its own specific functions. The brain is also divided into two hemispheres, the left and right, which are connected by a bundle of nerve fibers called the corpus callosum. Damage to the brain can result in a wide range of neurological disorders, including stroke, traumatic brain injury, Alzheimer's disease, Parkinson's disease, and epilepsy. Treatment for brain disorders often involves medications, surgery, and rehabilitation therapies to help restore function and improve quality of life.

Adult stem cells are a type of stem cell that are found in various tissues and organs of the adult body. These cells have the ability to self-renew and differentiate into specialized cell types, such as muscle cells, nerve cells, or blood cells, depending on the signals they receive from their environment. There are several types of adult stem cells, including hematopoietic stem cells, mesenchymal stem cells, and neural stem cells. Hematopoietic stem cells are responsible for producing all types of blood cells, while mesenchymal stem cells can differentiate into a variety of cell types, including bone, cartilage, and fat cells. Neural stem cells can differentiate into neurons and glial cells, which support and protect neurons in the brain and spinal cord. Adult stem cells have potential therapeutic applications in regenerative medicine, as they can be used to repair or replace damaged or diseased tissues and organs. For example, mesenchymal stem cells have been used in clinical trials to treat a variety of conditions, including heart disease, diabetes, and spinal cord injuries. However, more research is needed to fully understand the potential of adult stem cells and to develop safe and effective treatments using these cells.

Brain edema is a medical condition characterized by the accumulation of excess fluid in the brain tissue, leading to swelling and increased pressure within the skull. This can occur due to a variety of factors, including injury, infection, inflammation, or certain medical conditions such as hypertension or heart failure. Brain edema can cause a range of symptoms, including headache, nausea, vomiting, confusion, seizures, and loss of consciousness. In severe cases, it can lead to brain damage, coma, and even death. Treatment for brain edema typically involves addressing the underlying cause and reducing the pressure within the skull. This may involve medications to reduce inflammation or lower blood pressure, as well as procedures such as surgery to relieve pressure or remove excess fluid. In some cases, supportive care such as oxygen therapy or mechanical ventilation may also be necessary.

Brain ischemia is a medical condition that occurs when there is a lack of blood flow to the brain, which can lead to brain damage or even death. This can happen due to a blockage in one or more of the blood vessels that supply blood to the brain, or due to a decrease in the amount of oxygenated blood reaching the brain. Brain ischemia can be caused by a variety of factors, including stroke, heart disease, high blood pressure, and certain medical conditions such as sickle cell anemia. Symptoms of brain ischemia can include headache, confusion, dizziness, weakness, and loss of consciousness. Treatment for brain ischemia typically involves medications to dissolve blood clots or to reduce blood pressure, as well as surgery in some cases.

Brain death is a medical condition in which the brain is no longer capable of performing any vital functions, including maintaining heartbeat and respiration. It is a state of irreversible coma, and it is considered to be equivalent to death in most legal and ethical contexts. The diagnosis of brain death is typically made by a team of medical professionals, including neurologists, neurosurgeons, and critical care physicians. The process involves a series of tests and evaluations, including a neurological examination, imaging studies, and tests of brain function. Once brain death has been diagnosed, the patient is considered legally and medically dead, and organ donation may be considered. However, it is important to note that brain death is not the same as clinical death, which refers to the absence of heartbeat and breathing.

The cerebral cortex is the outermost layer of the brain, responsible for many of the higher functions of the nervous system, including perception, thought, memory, and consciousness. It is composed of two hemispheres, each of which is divided into four lobes: the frontal, parietal, temporal, and occipital lobes. The cerebral cortex is responsible for processing sensory information from the body and the environment, as well as generating motor commands to control movement. It is also involved in complex cognitive processes such as language, decision-making, and problem-solving. Damage to the cerebral cortex can result in a range of neurological and cognitive disorders, including dementia, aphasia, and apraxia.

The cerebellum is a part of the brain located at the base of the skull, just above the brainstem. It is responsible for coordinating and regulating many of the body's movements, as well as playing a role in balance, posture, and motor learning. The cerebellum receives information from the sensory systems, including the eyes, ears, and muscles, and uses this information to fine-tune motor movements and make them more precise and coordinated. It also plays a role in cognitive functions such as attention, language, and memory. Damage to the cerebellum can result in a range of movement disorders, including ataxia, which is characterized by uncoordinated and poorly controlled movements.

A brain abscess is a collection of pus that forms in the brain or spinal cord. It is a serious medical condition that requires prompt diagnosis and treatment. Brain abscesses can be caused by bacterial, fungal, or parasitic infections, as well as by injury or inflammation. Symptoms of a brain abscess may include headache, fever, nausea and vomiting, seizures, confusion, and changes in consciousness. Treatment typically involves antibiotics to treat the underlying infection, as well as surgery to drain the abscess and remove any infected tissue.,,。

In the medical field, "Animals, Newborn" typically refers to animals that are less than 28 days old. This age range is often used to describe the developmental stage of animals, particularly in the context of research or veterinary medicine. Newborn animals may require specialized care and attention, as they are often more vulnerable to illness and injury than older animals. They may also have unique nutritional and behavioral needs that must be addressed in order to promote their growth and development. In some cases, newborn animals may be used in medical research to study various biological processes, such as development, growth, and disease. However, the use of animals in research is highly regulated, and strict ethical guidelines must be followed to ensure the welfare and safety of the animals involved.

Hypoxia, brain refers to a condition in which the brain is not receiving enough oxygen. This can occur due to a variety of factors, including low oxygen levels in the blood, decreased blood flow to the brain, or damage to the blood vessels that supply oxygen to the brain. Hypoxia, brain can have serious consequences, as the brain is highly sensitive to oxygen deprivation. It can lead to a range of symptoms, including confusion, dizziness, headache, seizures, and loss of consciousness. In severe cases, it can cause permanent brain damage or even death. Treatment for hypoxia, brain depends on the underlying cause. In some cases, it may involve increasing oxygen levels in the blood through oxygen therapy or administering medications to improve blood flow to the brain. In other cases, it may require more aggressive interventions, such as surgery or mechanical ventilation. Early recognition and treatment of hypoxia, brain are critical for preventing long-term complications and improving outcomes.

Stem cell factor (SCF) is a protein that plays a crucial role in the development and maintenance of blood cells. It is also known as c-kit ligand because it binds to a protein called c-kit, which is found on the surface of certain types of cells, including hematopoietic stem cells. SCF is produced by a variety of cells, including endothelial cells, fibroblasts, and macrophages, and it acts as a growth factor for hematopoietic stem cells. It promotes the proliferation and differentiation of these cells, leading to the production of various types of blood cells, including red blood cells, white blood cells, and platelets. In addition to its role in hematopoiesis, SCF has been implicated in a variety of other biological processes, including angiogenesis, wound healing, and immune function. It has also been studied for its potential therapeutic applications in the treatment of various diseases, including cancer, anemia, and bone marrow failure.

In the medical field, "Cells, Cultured" refers to cells that have been grown and maintained in a controlled environment outside of their natural biological context, typically in a laboratory setting. This process is known as cell culture and involves the isolation of cells from a tissue or organism, followed by their growth and proliferation in a nutrient-rich medium. Cultured cells can be derived from a variety of sources, including human or animal tissues, and can be used for a wide range of applications in medicine and research. For example, cultured cells can be used to study the behavior and function of specific cell types, to develop new drugs and therapies, and to test the safety and efficacy of medical products. Cultured cells can be grown in various types of containers, such as flasks or Petri dishes, and can be maintained at different temperatures and humidity levels to optimize their growth and survival. The medium used to culture cells typically contains a combination of nutrients, growth factors, and other substances that support cell growth and proliferation. Overall, the use of cultured cells has revolutionized medical research and has led to many important discoveries and advancements in the field of medicine.

Auditory Brain Stem Implants (ABIs) are a type of medical device used to treat severe to profound hearing loss in individuals who have lost their ability to perceive sound through the normal hearing channels. ABIs work by bypassing the damaged parts of the inner ear and directly stimulating the auditory nerve, which sends signals to the brain about the sounds that are being detected. The ABI consists of an external sound processor that captures and processes sound, and an internal implant that is surgically placed in the brainstem. The sound processor sends electrical signals to the implant, which then stimulates the auditory nerve and sends the signals to the brain. The brain interprets these signals as sound, allowing the individual to perceive and understand speech and other sounds. ABIs are typically recommended for individuals who have lost their ability to hear through conventional hearing aids or cochlear implants, and who have a functioning auditory nerve. The implantation procedure is typically performed under general anesthesia and may take several hours. The recovery period can vary depending on the individual, but most people are able to return to their normal activities within a few weeks. Overall, ABIs can be an effective treatment option for individuals with severe to profound hearing loss who are not able to benefit from conventional hearing aids or cochlear implants. However, the success of the implantation depends on several factors, including the individual's age, the extent of their hearing loss, and their overall health.

Chronic brain damage refers to a type of damage that occurs over a prolonged period of time, typically months or years, and can result from a variety of causes such as stroke, traumatic brain injury, neurodegenerative diseases, infections, or substance abuse. Chronic brain damage can lead to a range of cognitive, emotional, and physical impairments, including memory loss, difficulty with language and communication, mood disorders, motor dysfunction, and changes in personality. The severity and extent of the damage can vary depending on the location and extent of the injury, as well as the individual's age, overall health, and other factors. Treatment for chronic brain damage typically involves a combination of medications, therapy, and lifestyle changes to manage symptoms and improve quality of life. In some cases, rehabilitation may also be necessary to help individuals regain lost skills and function.

Nerve tissue proteins are proteins that are found in nerve cells, also known as neurons. These proteins play important roles in the structure and function of neurons, including the transmission of electrical signals along the length of the neuron and the communication between neurons. There are many different types of nerve tissue proteins, each with its own specific function. Some examples of nerve tissue proteins include neurofilaments, which provide structural support for the neuron; microtubules, which help to maintain the shape of the neuron and transport materials within the neuron; and neurofilament light chain, which is involved in the formation of neurofibrillary tangles, which are a hallmark of certain neurodegenerative diseases such as Alzheimer's disease. Nerve tissue proteins are important for the proper functioning of the nervous system and any disruption in their production or function can lead to neurological disorders.

The Blood-Brain Barrier (BBB) is a highly selective semipermeable barrier that separates the circulating blood from the brain and spinal cord. It is formed by specialized endothelial cells that line the walls of the blood vessels in the brain and spinal cord, along with astrocytes and pericytes that support and regulate the BBB. The BBB plays a critical role in maintaining the homeostasis of the brain by regulating the transport of molecules and ions into and out of the brain. It acts as a barrier to prevent harmful substances, such as toxins and pathogens, from entering the brain, while allowing essential nutrients and signaling molecules to pass through. The BBB is also involved in the regulation of immune responses in the brain and spinal cord, and plays a role in the development and progression of neurological disorders such as multiple sclerosis, Alzheimer's disease, and stroke.

In the medical field, "Disease Models, Animal" refers to the use of animals to study and understand human diseases. These models are created by introducing a disease or condition into an animal, either naturally or through experimental manipulation, in order to study its progression, symptoms, and potential treatments. Animal models are used in medical research because they allow scientists to study diseases in a controlled environment and to test potential treatments before they are tested in humans. They can also provide insights into the underlying mechanisms of a disease and help to identify new therapeutic targets. There are many different types of animal models used in medical research, including mice, rats, rabbits, dogs, and monkeys. Each type of animal has its own advantages and disadvantages, and the choice of model depends on the specific disease being studied and the research question being addressed.

Cerebral ventricles are the cavities within the brain that are filled with cerebrospinal fluid (CSF). They are responsible for producing and circulating CSF, which serves as a cushion and lubricant for the brain and spinal cord, and helps to protect them from injury. The cerebral ventricles are divided into four main parts: the lateral ventricles, the third ventricle, the fourth ventricle, and the cerebellar ventricles. Disorders of the cerebral ventricles can lead to a variety of neurological symptoms, including headaches, seizures, and cognitive impairment.

In the medical field, "cats" typically refers to Felis catus, which is the scientific name for the domestic cat. Cats are commonly kept as pets and are known for their agility, playful behavior, and affectionate nature. In veterinary medicine, cats are commonly treated for a variety of health conditions, including respiratory infections, urinary tract infections, gastrointestinal issues, and dental problems. Cats can also be used in medical research to study various diseases and conditions, such as cancer, heart disease, and neurological disorders. In some cases, the term "cats" may also refer to a group of animals used in medical research or testing. For example, cats may be used to study the effects of certain drugs or treatments on the immune system or to test new vaccines.

In the medical field, a cell lineage refers to the developmental history of a cell, tracing its origin back to a common ancestor cell and following its subsequent divisions and differentiation into specialized cell types. Cell lineage is an important concept in the study of stem cells, which have the potential to differentiate into a wide variety of cell types. By understanding the cell lineage of stem cells, researchers can better understand how they develop into specific cell types and how they might be used to treat various diseases. In addition, cell lineage is also important in the study of cancer, as cancer cells often arise from normal cells that have undergone mutations and have begun to divide uncontrollably. By studying the cell lineage of cancer cells, researchers can gain insights into the genetic and molecular changes that have occurred during cancer development and identify potential targets for cancer therapy.

In the medical field, a decerebrate state refers to a condition in which the brainstem is damaged or removed, resulting in a lack of control over movement and reflexes. This can occur as a result of injury or disease affecting the brainstem, such as a stroke, tumor, or trauma. In a decerebrate state, the individual may have difficulty maintaining posture and balance, and may exhibit abnormal movements such as tremors or jerky, uncoordinated movements. They may also have difficulty swallowing and speaking, and may experience changes in their level of consciousness or responsiveness. Treatment for a decerebrate state depends on the underlying cause and may include medications to manage symptoms, physical therapy to improve movement and coordination, and other supportive care. In some cases, surgery may be necessary to address the underlying cause of the condition.

Cerebrovascular circulation refers to the blood flow to and from the brain and spinal cord. It is responsible for delivering oxygen and nutrients to the brain and removing waste products. The brain is a highly metabolically active organ, and it requires a constant supply of oxygen and nutrients to function properly. The cerebrovascular system is made up of the arteries, veins, and capillaries that supply blood to the brain. Any disruption in the cerebrovascular circulation can lead to serious health problems, including stroke and brain injury.

In the medical field, RNA, Messenger (mRNA) refers to a type of RNA molecule that carries genetic information from DNA in the nucleus of a cell to the ribosomes, where proteins are synthesized. During the process of transcription, the DNA sequence of a gene is copied into a complementary RNA sequence called messenger RNA (mRNA). This mRNA molecule then leaves the nucleus and travels to the cytoplasm of the cell, where it binds to ribosomes and serves as a template for the synthesis of a specific protein. The sequence of nucleotides in the mRNA molecule determines the sequence of amino acids in the protein that is synthesized. Therefore, changes in the sequence of nucleotides in the mRNA molecule can result in changes in the amino acid sequence of the protein, which can affect the function of the protein and potentially lead to disease. mRNA molecules are often used in medical research and therapy as a way to introduce new genetic information into cells. For example, mRNA vaccines work by introducing a small piece of mRNA that encodes for a specific protein, which triggers an immune response in the body.

The basilar artery is a large blood vessel located at the base of the brain. It is one of the three main arteries that supplies blood to the brain, along with the internal carotid arteries and vertebral arteries. The basilar artery arises from the fusion of the two vertebral arteries and runs downward through the brainstem, where it branches into two smaller arteries called the pontine arteries. The basilar artery is a crucial blood supply to the brainstem and cerebellum, and any damage or blockage to this artery can have serious consequences for brain function.

Cell proliferation refers to the process of cell division and growth, which is essential for the maintenance and repair of tissues in the body. In the medical field, cell proliferation is often studied in the context of cancer, where uncontrolled cell proliferation can lead to the formation of tumors and the spread of cancer cells to other parts of the body. In normal cells, cell proliferation is tightly regulated by a complex network of signaling pathways and feedback mechanisms that ensure that cells divide only when necessary and that they stop dividing when they have reached their full capacity. However, in cancer cells, these regulatory mechanisms can become disrupted, leading to uncontrolled cell proliferation and the formation of tumors. In addition to cancer, cell proliferation is also important in other medical conditions, such as wound healing, tissue regeneration, and the development of embryos. Understanding the mechanisms that regulate cell proliferation is therefore critical for developing new treatments for cancer and other diseases.

Brain infarction, also known as a stroke, is a medical condition that occurs when blood flow to a part of the brain is interrupted or reduced, leading to the death of brain cells in that area. This can be caused by a blockage in a blood vessel (ischemic stroke) or by bleeding in the brain (hemorrhagic stroke). The symptoms of brain infarction can vary depending on the location and size of the affected area of the brain. Common symptoms include sudden weakness or numbness in the face, arm, or leg, especially on one side of the body; difficulty speaking or understanding speech; vision problems; dizziness or loss of balance; and severe headache. Treatment for brain infarction depends on the cause and severity of the stroke. In some cases, medications may be used to dissolve blood clots or prevent further blood clots from forming. In other cases, surgery may be necessary to remove the blockage or repair damaged blood vessels. Rehabilitation may also be necessary to help patients recover from the effects of the stroke.

The Central Nervous System (CNS) is a complex network of nerves and neurons that controls and coordinates all bodily functions in the human body. It is composed of the brain and spinal cord, which are protected by the skull and vertebral column, respectively. The brain is the control center of the CNS and is responsible for processing sensory information, controlling movement, regulating bodily functions, and governing emotions and thoughts. It is divided into several regions, including the cerebrum, cerebellum, and brainstem. The spinal cord is a long, thin, tubular structure that extends from the base of the brain down through the vertebral column. It serves as a communication pathway between the brain and the rest of the body, transmitting signals from the body's sensory receptors to the brain and from the brain to the body's muscles and glands. Together, the brain and spinal cord make up the central nervous system, which is responsible for controlling and coordinating all bodily functions, including movement, sensation, thought, and emotion.

In the medical field, aging refers to the natural process of physical, biological, and psychological changes that occur over time in living organisms, including humans. These changes can affect various aspects of an individual's health and well-being, including their metabolism, immune system, cardiovascular system, skeletal system, and cognitive function. Aging is a complex process that is influenced by a combination of genetic, environmental, and lifestyle factors. As people age, their bodies undergo a gradual decline in function, which can lead to the development of age-related diseases and conditions such as arthritis, osteoporosis, cardiovascular disease, diabetes, and dementia. In the medical field, aging is studied in the context of geriatrics, which is the branch of medicine that focuses on the health and well-being of older adults. Geriatricians work to identify and manage age-related health issues, promote healthy aging, and improve the quality of life for older adults.

Brain stem hemorrhage, traumatic refers to a type of bleeding in the brain stem that occurs as a result of a traumatic injury, such as a blow to the head. The brain stem is the part of the brain that controls vital functions such as breathing, heart rate, and blood pressure. A traumatic brain stem hemorrhage can be life-threatening and can cause a range of symptoms, including headache, nausea, vomiting, confusion, and loss of consciousness. Treatment typically involves surgery to remove the blood clot and manage any underlying conditions that may have contributed to the hemorrhage.

Afferent pathways refer to the neural pathways that carry sensory information from the body's sensory receptors to the central nervous system (CNS), which includes the brain and spinal cord. These pathways are responsible for transmitting information about the external environment and internal bodily sensations to the CNS for processing and interpretation. Afferent pathways can be further divided into two types: sensory afferent pathways and motor afferent pathways. Sensory afferent pathways carry information about sensory stimuli, such as touch, temperature, pain, and pressure, from the body's sensory receptors to the CNS. Motor afferent pathways, on the other hand, carry information about the state of the body's muscles and organs to the CNS. Afferent pathways are essential for our ability to perceive and respond to the world around us. Any damage or dysfunction to these pathways can result in sensory deficits or other neurological disorders.

Cell differentiation is the process by which cells acquire specialized functions and characteristics during development. It is a fundamental process that occurs in all multicellular organisms, allowing cells to differentiate into various types of cells with specific functions, such as muscle cells, nerve cells, and blood cells. During cell differentiation, cells undergo changes in their shape, size, and function, as well as changes in the proteins and other molecules they produce. These changes are controlled by a complex network of genes and signaling pathways that regulate the expression of specific genes in different cell types. Cell differentiation is a critical process for the proper development and function of tissues and organs in the body. It is also involved in tissue repair and regeneration, as well as in the progression of diseases such as cancer, where cells lose their normal differentiation and become cancerous.

Astrocytes are a type of glial cell found in the central nervous system (CNS), including the brain and spinal cord. They are star-shaped cells that play a crucial role in supporting and maintaining the health of neurons, which are the nerve cells that transmit information throughout the brain and spinal cord. Astrocytes have many functions in the brain, including: 1. Providing structural support to neurons and synapses, the connections between neurons. 2. Regulating the extracellular environment by controlling the levels of ions, neurotransmitters, and other molecules in the brain. 3. Maintaining the blood-brain barrier, which protects the brain from harmful substances in the bloodstream. 4. Participating in the formation and repair of blood vessels in the brain. 5. Modulating the activity of neurons by releasing signaling molecules called gliotransmitters. Astrocytes are also involved in many neurological disorders, including Alzheimer's disease, multiple sclerosis, and epilepsy. Understanding the role of astrocytes in the brain is an active area of research in neuroscience and may lead to new treatments for these and other neurological conditions.

Deep Brain Stimulation (DBS) is a surgical procedure used to treat certain neurological and movement disorders, such as Parkinson's disease, dystonia, essential tremor, and epilepsy. The procedure involves implanting a small device, called a neurostimulator, into the brain, which sends electrical impulses to specific areas of the brain to reduce symptoms of the disorder. During DBS surgery, a neurosurgeon makes a small incision in the scalp and skull to access the brain. They then use imaging techniques, such as MRI or CT scans, to guide the placement of electrodes into the targeted area of the brain. The electrodes are connected to the neurostimulator, which is typically placed under the skin near the collarbone. Once the device is implanted, it can be programmed to deliver electrical impulses to the targeted area of the brain at specific intervals. The frequency and intensity of the impulses can be adjusted as needed to optimize symptom control and minimize side effects. DBS is considered a highly effective treatment for certain neurological and movement disorders, with many patients experiencing significant improvements in their symptoms after surgery. However, the procedure is not without risks, and patients should carefully weigh the potential benefits and risks with their healthcare provider before making a decision to undergo DBS.

Serotonin is a neurotransmitter, a chemical messenger that transmits signals between nerve cells in the brain and throughout the body. It plays a crucial role in regulating mood, appetite, sleep, and other bodily functions. In the medical field, serotonin is often studied in relation to mental health conditions such as depression, anxiety, and obsessive-compulsive disorder (OCD). Low levels of serotonin have been linked to these conditions, and medications such as selective serotonin reuptake inhibitors (SSRIs) are often prescribed to increase serotonin levels in the brain and improve symptoms. Serotonin is also involved in the regulation of pain perception, blood pressure, and other bodily functions. Imbalances in serotonin levels have been implicated in a variety of medical conditions, including migraines, fibromyalgia, and irritable bowel syndrome (IBS).

Glioma is a type of brain tumor that arises from the glial cells, which are the supportive cells of the brain and spinal cord. Gliomas are the most common type of primary brain tumor, accounting for about 80% of all brain tumors. They can occur in any part of the brain, but are most commonly found in the frontal and temporal lobes. Gliomas are classified based on their degree of malignancy, with grades I to IV indicating increasing levels of aggressiveness. Grade I gliomas are slow-growing and have a better prognosis, while grade IV gliomas are highly aggressive and have a poor prognosis. Symptoms of gliomas can vary depending on the location and size of the tumor, but may include headaches, seizures, changes in vision or speech, difficulty with coordination or balance, and personality changes. Treatment options for gliomas may include surgery, radiation therapy, chemotherapy, and targeted therapy, depending on the type and stage of the tumor.

The Cisterna Magna is a large, fluid-filled space located at the base of the brain, between the brainstem and the cerebellum. It is also known as the caudal cistern or the fourth ventricle. The Cisterna Magna is an important part of the central nervous system, as it serves as a reservoir for cerebrospinal fluid (CSF), which is produced by the choroid plexuses in the ventricles of the brain. The CSF circulates throughout the brain and spinal cord, providing cushioning and protection for the delicate neural tissue. The Cisterna Magna also plays a role in regulating the flow of CSF and maintaining the proper balance of pressure within the brain. Any problems with the Cisterna Magna, such as blockages or leaks, can lead to a variety of neurological symptoms and complications.

Atrophy refers to the decrease in size, volume, or mass of a body part or organ due to a lack of use, injury, or disease. In the medical field, atrophy can occur in various parts of the body, including muscles, organs, and tissues. For example, muscle atrophy can occur when a person is bedridden or has a sedentary lifestyle, leading to a decrease in muscle mass and strength. Organ atrophy can occur in conditions such as kidney failure, where the kidneys become smaller and less functional over time. Brain atrophy, also known as neurodegeneration, can occur in conditions such as Alzheimer's disease, where the brain's cells gradually die off, leading to a decline in cognitive function. Atrophy can also be a symptom of certain diseases or conditions, such as cancer, where the body's cells are damaged or destroyed, leading to a decrease in size and function of affected organs or tissues. In some cases, atrophy can be reversible with appropriate treatment, while in other cases, it may be permanent.

Encephalitis is a medical condition characterized by inflammation of the brain. It can be caused by a variety of factors, including viral or bacterial infections, autoimmune disorders, or exposure to certain toxins. Symptoms of encephalitis can vary widely and may include fever, headache, confusion, seizures, and changes in behavior or personality. In severe cases, encephalitis can lead to long-term neurological damage or even death. Treatment for encephalitis typically involves addressing the underlying cause of the inflammation and providing supportive care to manage symptoms and prevent complications.

The abducens nerve is the sixth cranial nerve, also known as the oculomotor nerve. It is responsible for controlling the movement of the eye by innervating the lateral rectus muscle, which is responsible for abduction (moving the eye outward). The abducens nerve also provides motor innervation to the superior oblique muscle, which is responsible for depression and abduction of the eye. The nerve arises from the brainstem and travels through the cavernous sinus to reach the orbit, where it supplies the muscles of the eye. Damage to the abducens nerve can result in diplopia (double vision) and other eye movement disorders.

Cerebellar diseases refer to a group of medical conditions that affect the cerebellum, a part of the brain responsible for coordinating movement, balance, and posture. The cerebellum is located at the base of the brain, just above the brainstem, and is divided into several lobes. Cerebellar diseases can be classified into two main categories: primary and secondary. Primary cerebellar diseases are those that affect the cerebellum directly, while secondary cerebellar diseases are those that affect the cerebellum as a result of damage to other parts of the brain or the body. Some common primary cerebellar diseases include: 1. Cerebellar ataxia: A group of disorders characterized by difficulty with balance,。 2. Spinocerebellar ataxia: A group of genetic disorders that affect the cerebellum and spinal cord. 3. Wilson's disease: A rare genetic disorder that causes copper to build up in the liver, brain, and other organs, leading to damage to the cerebellum. 4. Multiple sclerosis: A chronic autoimmune disorder that can affect the cerebellum and other parts of the brain and spinal cord. Some common secondary cerebellar diseases include: 1. Stroke: A cerebrovascular accident that occurs when blood flow to the brain is interrupted, leading to damage to the cerebellum. 2. Brain tumors: Tumors that grow in the brain can compress the cerebellum and cause symptoms such as difficulty with balance and coordination. 3. Infections: Infections such as meningitis and encephalitis can cause inflammation and damage to the cerebellum. 4. Trauma: Head injuries can cause damage to the cerebellum and lead to symptoms such as difficulty with balance and coordination. Treatment for cerebellar diseases depends on the underlying cause and the severity of symptoms. In some cases, medications may be used to manage symptoms or slow the progression of the disease. Physical therapy and other forms of rehabilitation may also be recommended to help improve balance, coordination, and other motor functions. In severe cases, surgery may be necessary to remove a brain tumor or repair damage to the cerebellum.

Auditory pathways refer to the neural pathways in the brain that are responsible for processing and interpreting sound information. These pathways begin in the cochlea, a structure in the inner ear that converts sound waves into electrical signals. From there, the signals travel through the auditory nerve to the brainstem, where they are processed by various nuclei before being sent to the auditory cortex in the temporal lobe for further analysis. The auditory pathways are responsible for a wide range of functions related to hearing, including the perception of sound intensity, frequency, and direction, as well as the ability to distinguish between different sounds and to understand speech. Damage to these pathways can result in hearing loss, tinnitus (ringing in the ears), and other auditory disorders.

In the medical field, "Behavior, Animal" refers to the study of the actions, responses, and interactions of animals, including humans, with their environment. This field encompasses a wide range of topics, including animal behavior in the wild, animal behavior in captivity, animal behavior in domestic settings, and animal behavior in laboratory settings. Animal behaviorists study a variety of behaviors, including social behavior, mating behavior, feeding behavior, communication behavior, and aggression. They use a variety of research methods, including observational studies, experiments, and surveys, to understand the underlying mechanisms that drive animal behavior. Animal behavior research has important applications in fields such as conservation biology, animal welfare, and veterinary medicine. For example, understanding animal behavior can help conservationists develop effective strategies for protecting endangered species, and it can help veterinarians develop more effective treatments for behavioral disorders in animals.

Analysis of Variance (ANOVA) is a statistical method used to compare the means of three or more groups. In the medical field, ANOVA can be used to compare the effectiveness of different treatments, interventions, or medications on a particular outcome or variable of interest. For example, a researcher may want to compare the effectiveness of three different medications for treating a particular disease. They could use ANOVA to compare the mean response (e.g., improvement in symptoms) between the three groups of patients who received each medication. If the results show a significant difference between the groups, it would suggest that one medication is more effective than the others. ANOVA can also be used to compare the means of different groups of patients based on a categorical variable, such as age, gender, or race. For example, a researcher may want to compare the mean blood pressure of patients in different age groups. They could use ANOVA to compare the mean blood pressure between the different age groups and determine if there are significant differences. Overall, ANOVA is a powerful statistical tool that can be used to compare the means of different groups in the medical field, helping researchers to identify which treatments or interventions are most effective and to better understand the factors that influence health outcomes.

Cranial nerves are a group of twelve pairs of nerves that emerge from the brainstem and are responsible for controlling various functions of the head and neck. These nerves are responsible for transmitting sensory information, such as touch, taste, and smell, as well as controlling movement and regulating vital functions such as heart rate and blood pressure. The cranial nerves are numbered and named according to their location and function. Some of the most well-known cranial nerves include the optic nerve (which carries visual information), the olfactory nerve (which carries information about smell), and the trigeminal nerve (which controls sensation in the face and head).

Brain diseases refer to a wide range of medical conditions that affect the structure, function, or chemistry of the brain. These diseases can be caused by a variety of factors, including genetic mutations, infections, injuries, toxins, and degenerative processes. Some common examples of brain diseases include: 1. Alzheimer's disease: A progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes. 2. Parkinson's disease: A movement disorder caused by the degeneration of dopamine-producing neurons in the brain. 3. Multiple sclerosis: An autoimmune disorder that affects the central nervous system, causing inflammation and damage to the myelin sheath that surrounds nerve fibers. 4. Huntington's disease: A genetic disorder that causes the progressive breakdown of nerve cells in the brain, leading to movement, cognitive, and psychiatric symptoms. 5. Epilepsy: A neurological disorder characterized by recurrent seizures, which can be caused by a variety of factors, including brain injury, genetic mutations, and brain tumors. 6. Stroke: A medical emergency caused by a disruption of blood flow to the brain, which can result in brain damage or death. 7. Brain tumors: Benign or malignant growths of abnormal cells in the brain that can cause a range of symptoms, depending on their location and size. These are just a few examples of the many different types of brain diseases that can affect people. Treatment options for brain diseases depend on the specific condition and its severity, and may include medications, surgery, physical therapy, and other interventions.

In the medical field, a base sequence refers to the specific order of nucleotides (adenine, thymine, cytosine, and guanine) that make up the genetic material (DNA or RNA) of an organism. The base sequence determines the genetic information encoded within the DNA molecule and ultimately determines the traits and characteristics of an individual. The base sequence can be analyzed using various techniques, such as DNA sequencing, to identify genetic variations or mutations that may be associated with certain diseases or conditions.

Action potentials are electrical signals that are generated by neurons in the nervous system. They are responsible for transmitting information throughout the body and are the basis of all neural communication. When a neuron is at rest, it has a negative electrical charge inside the cell and a positive charge outside the cell. When a stimulus is received by the neuron, it causes the membrane around the cell to become more permeable to sodium ions. This allows sodium ions to flow into the cell, causing the membrane potential to become more positive. This change in membrane potential is called depolarization. Once the membrane potential reaches a certain threshold, an action potential is generated. This is a rapid and brief change in the membrane potential that travels down the length of the neuron. The action potential is characterized by a rapid rise in membrane potential, followed by a rapid fall, and then a return to the resting membrane potential. Action potentials are essential for the proper functioning of the nervous system. They allow neurons to communicate with each other and transmit information throughout the body. They are also involved in a variety of important physiological processes, including muscle contraction, hormone release, and sensory perception.

Acute disseminated encephalomyelitis (ADEM) is a rare autoimmune disorder that affects the central nervous system (CNS). It is characterized by inflammation and damage to the myelin sheath, which is the protective covering of nerve fibers in the brain and spinal cord. In ADEM, the immune system mistakenly attacks the myelin sheath, causing it to break down and release inflammatory chemicals. This leads to inflammation and damage to the nerve fibers, which can result in a wide range of symptoms, including fever, headache, fatigue, and difficulty with coordination and balance. The symptoms of ADEM can vary widely depending on the location and severity of the inflammation in the brain and spinal cord. Some people may experience only mild symptoms, while others may have more severe symptoms that can be life-threatening. ADEM is usually a self-limiting condition, meaning that it will resolve on its own over time. However, in some cases, treatment with corticosteroids or other immunosuppressive drugs may be necessary to reduce inflammation and prevent further damage to the nervous system.

Audiometry, Evoked Response is a diagnostic test used to evaluate the function of the auditory system, specifically the hearing ability of an individual. It measures the electrical response of the auditory system to sound stimuli, which can help identify any abnormalities or damage to the auditory pathway. During the test, the patient is seated in a soundproof room and is asked to wear headphones or earplugs. A series of sounds, ranging from quiet to loud, are presented to the patient, and electrodes are placed on the scalp to record the electrical activity of the auditory system in response to the sounds. There are several types of evoked response audiometry tests, including: 1. Brainstem Auditory Evoked Response (BAER) test: This test measures the electrical activity in the brainstem in response to sound stimuli. 2. Auditory Middle Latency Response (AMLR) test: This test measures the electrical activity in the auditory cortex in response to sound stimuli. 3. Long Latency Auditory Evoked Potential (LLAEP) test: This test measures the electrical activity in the auditory cortex in response to sound stimuli, with a longer delay than the AMLR test. The results of evoked response audiometry tests can help diagnose hearing loss, identify the cause of hearing loss, and monitor the progression of hearing loss over time. It is often used in conjunction with other hearing tests, such as pure-tone audiometry, to provide a comprehensive evaluation of an individual's hearing ability.

Cerebral infarction, also known as a stroke, is a medical condition that occurs when blood flow to a part of the brain is interrupted, causing brain tissue to die. This can happen when a blood vessel in the brain becomes blocked by a clot or when a blood vessel bursts and leaks blood into the surrounding brain tissue. Cerebral infarction can cause a range of symptoms, depending on the location and size of the affected area of the brain. Common symptoms include sudden weakness or numbness in the face, arm, or leg, especially on one side of the body; difficulty speaking or understanding speech; vision problems; dizziness or loss of balance; and severe headache. Cerebral infarction is a medical emergency that requires prompt treatment to minimize the risk of long-term disability or death. Treatment options may include medications to dissolve or remove the blood clot, surgery to remove the clot or repair the damaged blood vessel, and rehabilitation to help patients recover from the effects of the stroke.

Bone marrow cells are the cells found in the bone marrow, which is the soft, spongy tissue found in the center of bones. These cells are responsible for producing blood cells, including red blood cells, white blood cells, and platelets. There are two types of bone marrow cells: hematopoietic stem cells and progenitor cells. Hematopoietic stem cells are capable of dividing and differentiating into any type of blood cell, while progenitor cells are capable of dividing and differentiating into specific types of blood cells. In the medical field, bone marrow cells are often used in the treatment of blood disorders, such as leukemia and lymphoma, as well as in the transplantation of bone marrow to replace damaged or diseased bone marrow. In some cases, bone marrow cells may also be used in research to study the development and function of blood cells.

In the medical field, oxygen is a gas that is essential for the survival of most living organisms. It is used to treat a variety of medical conditions, including respiratory disorders, heart disease, and anemia. Oxygen is typically administered through a mask, nasal cannula, or oxygen tank, and is used to increase the amount of oxygen in the bloodstream. This can help to improve oxygenation of the body's tissues and organs, which is important for maintaining normal bodily functions. In medical settings, oxygen is often used to treat patients who are experiencing difficulty breathing due to conditions such as pneumonia, chronic obstructive pulmonary disease (COPD), or asthma. It may also be used to treat patients who have suffered from a heart attack or stroke, as well as those who are recovering from surgery or other medical procedures. Overall, oxygen is a critical component of modern medical treatment, and is used in a wide range of clinical settings to help patients recover from illness and maintain their health.

In the medical field, a coma is a state of prolonged unconsciousness in which a person is unresponsive to their environment and cannot be awakened. Comas can be caused by a variety of factors, including head injuries, brain infections, drug overdose, and certain medical conditions such as stroke or heart attack. During a coma, a person's brain activity is significantly reduced, and they may show little to no signs of awareness or responsiveness. They may also experience changes in their vital signs, such as a slower heart rate and lower blood pressure. The duration of a coma can vary widely, from a few hours to several weeks or even months. In some cases, a person may emerge from a coma with no lasting effects, while in other cases, they may experience permanent brain damage or disability. Treatment for a coma typically involves addressing the underlying cause and providing supportive care to help the person's body recover.

Auditory Brain Stem Implantation (ABI) is a surgical procedure that involves the placement of an electrode array directly into the auditory nerve, which is located in the brainstem. The electrode array is connected to a speech processor, which converts sound into electrical signals that are transmitted directly to the auditory nerve. This allows individuals with severe to profound hearing loss to perceive sound and speech, even if they have no functional hearing in the outer or middle ear. The procedure is typically performed on individuals who have not responded to other forms of hearing rehabilitation, such as hearing aids or cochlear implants.

Alzheimer's disease is a progressive neurodegenerative disorder that affects memory, thinking, and behavior. It is the most common cause of dementia, a condition characterized by a decline in cognitive abilities severe enough to interfere with daily life. The disease is named after Alois Alzheimer, a German psychiatrist who first described it in 1906. Alzheimer's disease is characterized by the accumulation of abnormal protein deposits in the brain, including amyloid-beta plaques and neurofibrillary tangles. These deposits disrupt the normal functioning of brain cells, leading to their death and the progressive loss of cognitive abilities. Symptoms of Alzheimer's disease typically begin with mild memory loss and gradually worsen over time. As the disease progresses, individuals may experience difficulty with language, disorientation, and changes in personality and behavior. Eventually, they may become unable to care for themselves and require around-the-clock care. There is currently no cure for Alzheimer's disease, but treatments are available to manage symptoms and improve quality of life for those affected by the disease. These treatments may include medications, lifestyle changes, and support from caregivers and healthcare professionals.

Vertebrobasilar insufficiency (VBI) is a medical condition that occurs when there is a reduced blood flow to the brainstem and cerebellum, which are supplied by the vertebrobasilar artery system. This can lead to symptoms such as dizziness, balance problems, headache, and vision changes. VBI can be caused by a variety of factors, including atherosclerosis (hardening and narrowing of the arteries), blood clots, and certain medical conditions such as high blood pressure and diabetes. Treatment for VBI may include medications to improve blood flow or prevent blood clots, as well as lifestyle changes such as exercise and a healthy diet. In severe cases, surgery may be necessary.

In the medical field, a cell line refers to a group of cells that have been derived from a single parent cell and have the ability to divide and grow indefinitely in culture. These cells are typically grown in a laboratory setting and are used for research purposes, such as studying the effects of drugs or investigating the underlying mechanisms of diseases. Cell lines are often derived from cancerous cells, as these cells tend to divide and grow more rapidly than normal cells. However, they can also be derived from normal cells, such as fibroblasts or epithelial cells. Cell lines are characterized by their unique genetic makeup, which can be used to identify them and compare them to other cell lines. Because cell lines can be grown in large quantities and are relatively easy to maintain, they are a valuable tool in medical research. They allow researchers to study the effects of drugs and other treatments on specific cell types, and to investigate the underlying mechanisms of diseases at the cellular level.

In the medical field, an amino acid sequence refers to the linear order of amino acids in a protein molecule. Proteins are made up of chains of amino acids, and the specific sequence of these amino acids determines the protein's structure and function. The amino acid sequence is determined by the genetic code, which is a set of rules that specifies how the sequence of nucleotides in DNA is translated into the sequence of amino acids in a protein. Each amino acid is represented by a three-letter code, and the sequence of these codes is the amino acid sequence of the protein. The amino acid sequence is important because it determines the protein's three-dimensional structure, which in turn determines its function. Small changes in the amino acid sequence can have significant effects on the protein's structure and function, and this can lead to diseases or disorders. For example, mutations in the amino acid sequence of a protein involved in blood clotting can lead to bleeding disorders.

Blotting, Western is a laboratory technique used to detect specific proteins in a sample by transferring proteins from a gel to a membrane and then incubating the membrane with a specific antibody that binds to the protein of interest. The antibody is then detected using an enzyme or fluorescent label, which produces a visible signal that can be quantified. This technique is commonly used in molecular biology and biochemistry to study protein expression, localization, and function. It is also used in medical research to diagnose diseases and monitor treatment responses.

In the medical field, brain waves refer to the electrical activity that occurs in the brain. These electrical signals are generated by the movement of ions across the cell membranes of neurons in the brain. Brain waves can be measured using an electroencephalogram (EEG), which is a non-invasive test that records the electrical activity of the brain. There are several different types of brain waves, each with its own characteristic frequency and pattern. The most common types of brain waves are: 1. Alpha waves: These are the most common type of brain wave, and they occur when a person is relaxed and awake. Alpha waves have a frequency of 8-13 Hz. 2. Beta waves: These brain waves occur when a person is alert and focused. Beta waves have a frequency of 14-30 Hz. 3. Theta waves: These brain waves occur when a person is in a light sleep or daydreaming state. Theta waves have a frequency of 4-7 Hz. 4. Delta waves: These brain waves occur when a person is in a deep sleep state. Delta waves have a frequency of less than 4 Hz. Brain waves can be used to diagnose and monitor a variety of neurological conditions, including epilepsy, sleep disorders, and brain injuries. They can also be used to study the effects of drugs and other substances on brain function.

Octamer Transcription Factor-3 (Oct3/4) is a transcription factor that plays a crucial role in the regulation of gene expression during embryonic development and stem cell maintenance. It is a member of the POU family of transcription factors, which are characterized by a conserved DNA-binding domain called the POU domain. Oct3/4 is expressed in the inner cell mass of the blastocyst, which gives rise to the embryo proper, and in the embryonic stem cells that can differentiate into all cell types of the body. It is also expressed in some adult tissues, such as the brain and testes. In stem cells, Oct3/4 is essential for maintaining their self-renewal capacity and pluripotency, which allows them to differentiate into any cell type in the body. It does this by binding to specific DNA sequences called Octamer boxes, which are located in the promoter regions of genes that are important for stem cell maintenance and differentiation. In addition to its role in stem cells, Oct3/4 has also been implicated in the development of various diseases, including cancer. For example, some cancer cells can reprogram themselves to express Oct3/4, which allows them to evade immune surveillance and continue to grow and divide uncontrollably. Therefore, targeting Oct3/4 may be a promising strategy for the treatment of certain types of cancer.

Autoradiography is a technique used in the medical field to visualize the distribution of radioactive substances within a biological sample. It involves exposing a sample to a small amount of a radioactive tracer, which emits radiation as it decays. The emitted radiation is then detected and recorded using a special film or imaging device, which produces an image of the distribution of the tracer within the sample. Autoradiography is commonly used in medical research to study the metabolism and distribution of drugs, hormones, and other substances within the body. It can also be used to study the growth and spread of tumors, as well as to investigate the structure and function of cells and tissues. In some cases, autoradiography can be used to visualize the distribution of specific proteins or other molecules within cells and tissues.

Chemoreceptor cells are specialized sensory cells that detect changes in chemical concentrations in the environment. In the medical field, chemoreceptor cells are particularly important in the regulation of breathing and heart rate. There are two main types of chemoreceptor cells: central chemoreceptors and peripheral chemoreceptors. Central chemoreceptors are located in the medulla oblongata of the brainstem and detect changes in the levels of oxygen and carbon dioxide in the blood. Peripheral chemoreceptors are located in the carotid and aortic bodies in the neck and chest, respectively, and detect changes in the levels of oxygen and carbon dioxide in the blood as well as other chemicals such as hydrogen ions and lactic acid. When the levels of oxygen or carbon dioxide in the blood change, the chemoreceptor cells respond by sending signals to the brainstem, which then adjusts the rate and depth of breathing to maintain the proper balance of gases in the blood. Similarly, when the levels of other chemicals such as hydrogen ions or lactic acid change, the chemoreceptor cells can trigger changes in heart rate and blood pressure to help the body maintain homeostasis. Overall, chemoreceptor cells play a critical role in regulating the body's response to changes in chemical concentrations in the environment, particularly in the context of breathing and heart rate.

Strychnine is a highly toxic alkaloid found in certain plants, including the seeds of the Strychnos nux-vomica tree. It is known for its ability to stimulate the central nervous system, leading to symptoms such as muscle spasms, convulsions, and hallucinations. In the medical field, strychnine is sometimes used as a muscle relaxant or as a treatment for certain types of muscle spasms. However, due to its toxicity, it is only used under the supervision of a qualified healthcare professional and is typically administered in very small doses. Strychnine is also used as a pesticide and is sometimes found in illicit drugs.

Gamma-Aminobutyric Acid (GABA) is a neurotransmitter that plays a crucial role in the central nervous system. It is a non-protein amino acid that is synthesized from glutamate in the brain and spinal cord. GABA acts as an inhibitory neurotransmitter, meaning that it reduces the activity of neurons and helps to calm and relax the brain. In the medical field, GABA is often used as a treatment for anxiety disorders, insomnia, and epilepsy. It is available as a dietary supplement and can also be prescribed by a doctor in the form of medication. GABA supplements are believed to help reduce feelings of anxiety and promote relaxation by increasing the levels of GABA in the brain. However, more research is needed to fully understand the effects of GABA on the human body and to determine the most effective ways to use it as a treatment.

The cranial fossa, posterior refers to the posterior part of one of the four main cavities or spaces within the skull. The skull is composed of several bones that fit together to form a protective structure around the brain. The cranial fossae are the main cavities within the skull that house the brain. There are four main cranial fossae: the anterior cranial fossa, the middle cranial fossa, the posterior cranial fossa, and the temporal fossa. The posterior cranial fossa is located at the back of the skull, behind the middle cranial fossa. It is the largest of the four cranial fossae and contains several important structures, including the cerebellum, the brainstem, and the occipital lobe of the cerebrum. The posterior cranial fossa is bounded by several bones, including the occipital bone, the cerebellar peduncles, and the tentorium cerebelli. The tentorium cerebelli is a thin, translucent membrane that separates the cerebellum from the brainstem. The cerebellar peduncles are the two thickened areas of the brainstem that connect the cerebellum to the rest of the brain. The posterior cranial fossa is an important part of the skull and plays a crucial role in protecting the brain. Any damage to the bones that form the posterior cranial fossa can potentially cause serious injury to the brain.

Cerebral hemorrhage, also known as intracerebral hemorrhage, is a medical emergency that occurs when a blood vessel in the brain ruptures, causing blood to leak into the surrounding brain tissue. This can cause severe brain damage and can be life-threatening if not treated promptly. Cerebral hemorrhage is a type of stroke, which is a leading cause of disability and death worldwide. It can occur due to a variety of factors, including high blood pressure, aneurysms, brain tumors, and certain medications. Symptoms of cerebral hemorrhage can include sudden and severe headache, nausea and vomiting, confusion, loss of consciousness, weakness or numbness in the face, arms, or legs, difficulty speaking or understanding speech, and vision problems. Treatment for cerebral hemorrhage typically involves reducing blood pressure, controlling bleeding, and managing symptoms. In some cases, surgery may be necessary to remove the blood clot or repair the ruptured blood vessel. The outcome of cerebral hemorrhage depends on the severity of the bleeding, the location of the hemorrhage in the brain, and the promptness and effectiveness of treatment.

The cochlear nerve, also known as the vestibulocochlear nerve (CN VIII), is the eighth cranial nerve in the human body. It is responsible for transmitting sound and balance information from the inner ear (cochlea and vestibule) to the brainstem. The cochlear nerve is a mixed nerve, meaning it contains both sensory and motor fibers. The sensory fibers carry information about sound and balance, while the motor fibers control the muscles of the middle ear. Damage to the cochlear nerve can result in hearing loss, vertigo, and balance disorders. It is an important part of the auditory system and plays a crucial role in our ability to hear and maintain balance.

Glial Fibrillary Acidic Protein (GFAP) is a protein that is primarily found in astrocytes, which are a type of glial cell in the central nervous system. GFAP is a structural protein that helps to maintain the shape and stability of astrocytes, and it is also involved in various cellular processes such as cell signaling and communication. In the medical field, GFAP is often used as a diagnostic marker for certain neurological conditions, particularly those that involve damage or dysfunction of astrocytes. For example, increased levels of GFAP in the cerebrospinal fluid or brain tissue have been associated with a variety of neurological disorders, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury. Additionally, GFAP has been studied as a potential therapeutic target for these and other neurological conditions, as it plays a key role in astrocyte function and may be involved in the development and progression of disease.

Astrocytoma is a type of brain tumor that arises from astrocytes, which are star-shaped cells that support and nourish neurons in the brain. Astrocytomas are the most common type of primary brain tumor, accounting for about 30% of all brain tumors. They can occur at any age, but are most common in adults between the ages of 40 and 60. Astrocytomas are classified into four grades based on their degree of malignancy and ability to invade surrounding tissues. Grade I astrocytomas are slow-growing and low-grade, while grade IV astrocytomas are highly aggressive and fast-growing. Treatment options for astrocytomas depend on the grade of the tumor, the location of the tumor in the brain, and the patient's overall health. Treatment may include surgery, radiation therapy, chemotherapy, and targeted therapy.

In the medical field, cell separation refers to the process of isolating specific types of cells from a mixture of cells. This can be done for a variety of reasons, such as to study the properties and functions of a particular cell type, to prepare cells for transplantation, or to remove unwanted cells from a sample. There are several methods for cell separation, including centrifugation, fluorescence-activated cell sorting (FACS), and magnetic bead separation. Centrifugation involves spinning a sample of cells at high speeds to separate them based on their size and density. FACS uses lasers to excite fluorescent markers on the surface of cells, allowing them to be sorted based on their fluorescence intensity. Magnetic bead separation uses magnetic beads coated with antibodies to bind to specific cell surface markers, allowing them to be separated from other cells using a magnetic field. Cell separation is an important technique in many areas of medicine, including cancer research, stem cell biology, and immunology. It allows researchers to study specific cell types in detail and to develop new treatments for diseases based on a better understanding of cell biology.

Glutamic acid is an amino acid that is naturally occurring in the human body and is essential for various bodily functions. It is a non-essential amino acid, meaning that the body can produce it from other compounds, but it is still important for maintaining good health. In the medical field, glutamic acid is sometimes used as a medication to treat certain conditions. For example, it is used to treat epilepsy, a neurological disorder characterized by recurrent seizures. Glutamic acid is also used to treat certain types of brain injuries, such as stroke, by promoting the growth of new brain cells. In addition to its medicinal uses, glutamic acid is also an important component of the diet. It is found in many foods, including meats, fish, poultry, dairy products, and grains. It is also available as a dietary supplement.

Apnea is a medical term that refers to a temporary cessation of breathing. It can occur in both children and adults and can be caused by a variety of factors, including sleep disorders, respiratory problems, and neurological conditions. In medical settings, apnea is typically diagnosed through a sleep study, which involves monitoring a person's breathing patterns while they sleep. There are different types of apnea, including obstructive sleep apnea, central sleep apnea, and mixed sleep apnea. Obstructive sleep apnea occurs when the airway becomes blocked during sleep, preventing air from flowing in and out of the lungs. Central sleep apnea occurs when the brain fails to send signals to the muscles that control breathing, leading to pauses in breathing. Mixed sleep apnea is a combination of both obstructive and central sleep apnea. Untreated sleep apnea can lead to a range of health problems, including high blood pressure, heart disease, stroke, and diabetes. Treatment options for sleep apnea may include lifestyle changes, such as weight loss and quitting smoking, as well as the use of continuous positive airway pressure (CPAP) machines or other medical devices to help keep the airway open during sleep.

The cochlear nucleus is a part of the auditory pathway in the brainstem that receives and processes information from the cochlea, which is the sensory organ of hearing. It is located in the ventral cochlear sulcus, which is a groove in the medulla oblongata of the brainstem. The cochlear nucleus receives input from the cochlear nerve, which carries auditory information from the cochlea to the brainstem. The cochlear nucleus then sends information to other parts of the brain, including the inferior colliculus and the auditory cortex, which are involved in processing and interpreting sound. Damage to the cochlear nucleus can result in hearing loss or other auditory disorders. It is also involved in the processing of other types of sensory information, such as balance and spatial orientation.

A craniotomy is a surgical procedure in which a portion of the skull is removed to access the brain. It is typically performed to treat brain tumors, bleeding, infections, or other conditions that require direct access to the brain. During a craniotomy, a surgeon will make an incision in the scalp and remove a portion of the skull, called a bone flap, to expose the brain. The surgeon will then perform the necessary procedures to treat the underlying condition and then replace the bone flap and close the incision in the scalp. Craniotomies are typically performed under general anesthesia and may require a period of recovery in the hospital.

Anoxia is a medical condition characterized by a lack of oxygen in the body's tissues. This can occur due to a variety of factors, including low oxygen levels in the air, reduced blood flow to the tissues, or a lack of oxygen-carrying red blood cells. Anoxia can lead to a range of symptoms, including confusion, dizziness, shortness of breath, and loss of consciousness. In severe cases, anoxia can be life-threatening and may require immediate medical attention.

Rhodanine is a heterocyclic organic compound with the chemical formula C4H4N2O2. It is a white, crystalline solid that is soluble in water and alcohol. Rhodanine is used in the medical field as a starting material for the synthesis of various pharmaceuticals and as a reagent in analytical chemistry. It has also been studied for its potential therapeutic effects, including anti-inflammatory, anti-cancer, and anti-viral activity. However, more research is needed to fully understand its potential medical applications.

In the medical field, "cell count" refers to the measurement of the number of cells present in a specific sample of tissue or fluid. This measurement is typically performed using a microscope and a specialized staining technique to distinguish between different types of cells. For example, a complete blood count (CBC) is a common laboratory test that measures the number and types of cells in the blood, including red blood cells, white blood cells, and platelets. Similarly, a urine analysis may include a cell count to measure the number of white blood cells or bacteria present in the urine. Cell counts can be used to diagnose a variety of medical conditions, such as infections, inflammation, or cancer. They can also be used to monitor the effectiveness of treatments or to detect any changes in the body's cellular makeup over time.

Dopamine is a neurotransmitter that plays a crucial role in the brain's reward and pleasure centers. It is also involved in regulating movement, motivation, and emotional responses. In the medical field, dopamine is often used to treat conditions such as Parkinson's disease, which is characterized by a lack of dopamine in the brain. It can also be used to treat high blood pressure, as well as to manage symptoms of depression and schizophrenia. Dopamine is typically administered through injections or intravenous infusions, although it can also be taken orally in some cases.

Cortical Spreading Depression (CSD) is a phenomenon that occurs in the cerebral cortex, which is the outer layer of the brain. It is characterized by a wave of depolarization that spreads across the cortex, followed by a period of hyperpolarization. This wave of depolarization is accompanied by a decrease in blood flow, a decrease in oxygen levels, and an increase in glutamate release. CSD is thought to play a role in a variety of neurological conditions, including migraine headaches, stroke, and epilepsy. It is also thought to be involved in the spread of brain injury following trauma, and in the development of neurodegenerative diseases such as Alzheimer's and Parkinson's. CSD is typically studied using electroencephalography (EEG), which measures the electrical activity of the brain. It is also studied using magnetic resonance imaging (MRI), which can visualize changes in blood flow and oxygen levels in the brain during a CSD event.

Biological markers, also known as biomarkers, are measurable indicators of biological processes, pathogenic processes, or responses to therapeutic interventions. In the medical field, biological markers are used to diagnose, monitor, and predict the progression of diseases, as well as to evaluate the effectiveness of treatments. Biological markers can be found in various biological samples, such as blood, urine, tissue, or body fluids. They can be proteins, genes, enzymes, hormones, metabolites, or other molecules that are associated with a specific disease or condition. For example, in cancer, biological markers such as tumor markers can be used to detect the presence of cancer cells or to monitor the response to treatment. In cardiovascular disease, biological markers such as cholesterol levels or blood pressure can be used to assess the risk of heart attack or stroke. Overall, biological markers play a crucial role in medical research and clinical practice, as they provide valuable information about the underlying biology of diseases and help to guide diagnosis, treatment, and monitoring.

Leukoencephalopathies are a group of neurological disorders characterized by damage to the white matter of the brain. The white matter is made up of nerve fibers that transmit signals between different parts of the brain and spinal cord. Damage to these fibers can result in a variety of symptoms, depending on the specific type of leukoencephalopathy and the location of the affected white matter. There are many different types of leukoencephalopathies, including inherited disorders such as Alexander disease, Canavan disease, and Pelizaeus-Merzbacher disease, as well as acquired disorders such as multiple sclerosis, HIV-related encephalopathy, and hypoxic-ischemic encephalopathy. Some leukoencephalopathies are progressive, meaning that the symptoms worsen over time, while others are static, meaning that the symptoms remain the same or improve slightly. Symptoms of leukoencephalopathy can vary widely depending on the specific disorder and the location of the affected white matter. Common symptoms include difficulty with movement, coordination, and balance, as well as cognitive and behavioral changes such as memory loss, difficulty with language and communication, and mood disorders. In some cases, leukoencephalopathy can also cause seizures, vision problems, and hearing loss.

A cordotomy is a surgical procedure that involves cutting or severing the spinal cord to relieve pain. It is typically performed when other pain management methods have been unsuccessful and the pain is severe and unrelenting. The procedure is usually done under general anesthesia and involves making a small incision in the skin over the spinal cord, then using a special instrument to cut or sever a small section of the cord. The goal of a cordotomy is to interrupt the nerve signals that are causing the pain, but it does not affect the ability to move or feel sensations below the level of the cut. Cordotomy is typically used to treat chronic pain conditions such as cancer pain, complex regional pain syndrome (CRPS), and severe back pain.

Norepinephrine, also known as noradrenaline, is a neurotransmitter and hormone that plays a crucial role in the body's "fight or flight" response. It is produced by the adrenal glands and is also found in certain neurons in the brain and spinal cord. In the medical field, norepinephrine is often used as a medication to treat low blood pressure, shock, and heart failure. It works by constricting blood vessels and increasing heart rate, which helps to raise blood pressure and improve blood flow to vital organs. Norepinephrine is also used to treat certain types of depression, as it can help to increase feelings of alertness and energy. However, it is important to note that norepinephrine can have side effects, including rapid heartbeat, high blood pressure, and anxiety, and should only be used under the supervision of a healthcare professional.

Nestin is a type of intermediate filament protein that is expressed in various types of stem cells, including neural stem cells, muscle stem cells, and hematopoietic stem cells. It is a marker of neural progenitor cells and is often used to identify and isolate these cells for research and therapeutic purposes. In the medical field, Nestin is also used as a diagnostic tool to identify certain types of tumors, such as gliomas and neuroblastomas, which often express high levels of Nestin. Additionally, Nestin has been shown to play a role in the development and maintenance of neural stem cells, making it a potential target for therapies aimed at promoting neural regeneration and repair.

Blood pressure is the force exerted by the blood against the walls of the blood vessels as the heart pumps blood through the body. It is measured in millimeters of mercury (mmHg) and is typically expressed as two numbers: systolic pressure (the pressure when the heart beats) and diastolic pressure (the pressure when the heart is at rest between beats). Normal blood pressure is considered to be below 120/80 mmHg, while high blood pressure (hypertension) is defined as a systolic pressure of 140 mmHg or higher and/or a diastolic pressure of 90 mmHg or higher. High blood pressure is a major risk factor for heart disease, stroke, and other health problems.

Proto-oncogene proteins c-fos are a group of proteins that play a role in cell growth and differentiation. They are encoded by the c-fos gene and are involved in the regulation of cell proliferation, differentiation, and survival. In normal cells, c-fos proteins are expressed at low levels and play a role in the regulation of cell growth and differentiation. However, in cancer cells, the expression of c-fos proteins is often increased, leading to uncontrolled cell growth and the development of cancer. Proto-oncogene proteins c-fos are therefore considered to be oncogenes, which are genes that have the potential to cause cancer.

Nervous system diseases refer to a broad range of medical conditions that affect the nervous system, which is responsible for transmitting signals between different parts of the body. These diseases can affect any part of the nervous system, including the brain, spinal cord, nerves, and muscles. Some examples of nervous system diseases include: 1. Neurodegenerative diseases: These are conditions that cause the progressive loss of nerve cells and their functions, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. Neuromuscular diseases: These are conditions that affect the muscles and nerves that control movement, such as muscular dystrophy, amyotrophic lateral sclerosis (ALS), and multiple sclerosis. 3. Neurological disorders: These are conditions that affect the brain and nervous system, such as epilepsy, stroke, and traumatic brain injury. 4. Neuropsychiatric disorders: These are conditions that affect the brain and behavior, such as schizophrenia, bipolar disorder, and depression. 5. Infections of the nervous system: These are conditions caused by infections, such as meningitis, encephalitis, and neurocysticercosis. Treatment for nervous system diseases depends on the specific condition and can include medications, surgery, physical therapy, and lifestyle changes. Early diagnosis and treatment are important for improving outcomes and managing symptoms.

Chronic brain injury refers to a type of brain injury that persists over a long period of time, typically lasting for more than six months. It can result from a variety of causes, including traumatic brain injury, stroke, or neurodegenerative diseases such as Alzheimer's or Parkinson's. Chronic brain injury can have a wide range of effects on a person's cognitive, physical, and emotional functioning. These effects can vary depending on the severity and location of the injury, as well as the individual's age, overall health, and other factors. Symptoms of chronic brain injury may include memory loss, difficulty with concentration and attention, mood changes, physical weakness or coordination problems, and changes in speech or language. Treatment for chronic brain injury typically involves a combination of medications, therapy, and lifestyle changes to manage symptoms and improve functioning.

Acoustic Stimulation refers to the use of sound waves to stimulate or activate certain areas of the brain or body. This technique is commonly used in the medical field for various purposes, including: 1. Treating hearing loss: Acoustic Stimulation can be used to stimulate the auditory nerve and improve hearing in individuals with sensorineural hearing loss. 2. Treating tinnitus: Acoustic Stimulation can be used to reduce the perception of ringing or buzzing in the ears, which is commonly known as tinnitus. 3. Treating sleep disorders: Acoustic Stimulation can be used to promote relaxation and improve sleep in individuals with insomnia or other sleep disorders. 4. Treating neurological disorders: Acoustic Stimulation can be used to stimulate specific areas of the brain to improve symptoms of neurological disorders such as Parkinson's disease, stroke, and traumatic brain injury. Acoustic Stimulation is typically delivered through a device that emits low-level sound waves, which are then directed to the targeted area of the body or brain. The frequency and intensity of the sound waves can be adjusted to optimize the therapeutic effect.

CD34 is a protein found on the surface of certain cells in the body, including hematopoietic stem cells, progenitor cells, and endothelial cells. In the medical field, CD34 is often used as a marker to identify and isolate these cells for various purposes, such as in bone marrow transplantation or in research studies. Antigens, CD34 refers to the specific portion of the CD34 protein that serves as an antigen, or a substance that triggers an immune response in the body. Antigens, CD34 can be used as a diagnostic tool to detect the presence of certain diseases or conditions, such as certain types of leukemia or myelodysplastic syndromes. They can also be used in the development of targeted therapies for these conditions.

Cerebellar neoplasms, also known as cerebellar tumors, are abnormal growths of cells that develop in the cerebellum, which is the part of the brain responsible for controlling balance, coordination, and movement. These tumors can be either benign (non-cancerous) or malignant (cancerous) and can occur at any age, although they are more common in adults. Cerebellar neoplasms can cause a variety of symptoms, depending on their size and location. Some common symptoms include headache, nausea and vomiting, dizziness, unsteadiness, difficulty with coordination and balance, weakness or numbness in the limbs, and changes in speech or vision. Diagnosis of cerebellar neoplasms typically involves a combination of imaging tests, such as MRI or CT scans, and a biopsy to confirm the presence of cancer cells. Treatment options for cerebellar neoplasms depend on the type, size, and location of the tumor, as well as the patient's overall health and preferences. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.

In the medical field, carbon dioxide (CO2) is a gas that is produced as a byproduct of cellular respiration and is exhaled by the body. It is also used in medical applications such as carbon dioxide insufflation during colonoscopy and laparoscopic surgery, and as a component of medical gases used in anesthesia and respiratory therapy. High levels of CO2 in the blood (hypercapnia) can be a sign of respiratory or metabolic disorders, while low levels (hypocapnia) can be caused by respiratory failure or metabolic alkalosis.

The cardiovascular system is a complex network of organs and tissues that work together to pump blood throughout the body. It is responsible for delivering oxygen and nutrients to the body's cells and removing waste products. The main components of the cardiovascular system include the heart, blood vessels (arteries, veins, and capillaries), and blood. The heart is a muscular organ that pumps blood throughout the body. It is divided into four chambers: the right atrium, right ventricle, left atrium, and left ventricle. The right side of the heart pumps deoxygenated blood to the lungs, where it picks up oxygen and releases carbon dioxide. The left side of the heart pumps oxygenated blood to the rest of the body. Blood vessels are responsible for transporting blood throughout the body. Arteries carry oxygenated blood away from the heart, while veins carry deoxygenated blood back to the heart. Capillaries are tiny blood vessels that connect arteries and veins and allow for the exchange of oxygen, nutrients, and waste products between the blood and body tissues. Together, the heart, blood vessels, and blood make up the cardiovascular system, which is essential for maintaining the health and function of the body.

SOXB1 transcription factors are a family of proteins that play a crucial role in regulating gene expression in various biological processes, including development, differentiation, and homeostasis. The SOXB1 family includes three members: SOX9, SOX8, and SOX10. SOX9 is primarily expressed in the developing testis and is essential for the development of male sexual characteristics. It also plays a role in the development of the skeleton, cartilage, and bone. SOX8 is expressed in a variety of tissues, including the brain, heart, and skeletal muscle. It is involved in the regulation of cell proliferation and differentiation, as well as the development of the nervous system. SOX10 is expressed in neural crest cells, which give rise to a variety of cell types, including melanocytes, Schwann cells, and neurons. It is involved in the development of the peripheral nervous system, as well as the development of the skin and eyes. Mutations in SOXB1 transcription factors have been associated with a variety of human diseases, including developmental disorders, cancers, and neurological disorders. Understanding the function of these transcription factors is important for developing new treatments for these diseases.

In the medical field, consciousness refers to an individual's awareness of their surroundings, thoughts, and emotions. It is the subjective experience of being awake and aware of one's environment, thoughts, and feelings. Consciousness is often assessed through various clinical measures, such as the Glasgow Coma Scale, which evaluates a patient's level of consciousness based on their eye opening, verbal response, and motor response to stimuli. Consciousness is a complex and multifaceted phenomenon that is not yet fully understood by scientists. It is thought to involve the activity of various brain regions, including the prefrontal cortex, thalamus, and brainstem. Disorders of consciousness, such as coma, vegetative state, and minimally conscious state, can result from damage to these brain regions and can have significant implications for a patient's quality of life and prognosis.

The Area Postrema is a small region located at the base of the fourth ventricle in the brainstem. It is a part of the chemoreceptor trigger zone (CTZ), which is responsible for regulating various autonomic functions, including appetite, nausea, and vomiting. The Area Postrema is particularly important in the regulation of vomiting, as it contains receptors that respond to various chemicals that can trigger nausea and vomiting, such as toxins, infections, and certain medications. When these chemicals are detected in the bloodstream, they bind to receptors in the Area Postrema, which sends signals to the brainstem and spinal cord to initiate vomiting. In addition to its role in vomiting, the Area Postrema is also involved in the regulation of appetite and satiety. It contains receptors that respond to various hormones and neurotransmitters that are involved in hunger and fullness, such as ghrelin and leptin. Damage to the Area Postrema can result in a condition called persistent vomiting, which is characterized by persistent nausea and vomiting that is not relieved by normal treatments. It can also lead to other autonomic dysfunction, such as changes in heart rate and blood pressure.

Receptors, Glycine are a type of ionotropic receptor that are activated by the neurotransmitter glycine. These receptors are found in the central nervous system and are involved in a variety of physiological processes, including muscle relaxation, sleep regulation, and pain perception. Activation of glycine receptors leads to the opening of ion channels, allowing positively charged ions to flow into the cell and causing a change in the electrical potential across the cell membrane. This change in membrane potential can lead to the generation of an electrical signal, which can then be transmitted to other cells in the nervous system.

Green Fluorescent Proteins (GFPs) are a class of proteins that emit green light when excited by blue or ultraviolet light. They were first discovered in the jellyfish Aequorea victoria and have since been widely used as a tool in the field of molecular biology and bioimaging. In the medical field, GFPs are often used as a marker to track the movement and behavior of cells and proteins within living organisms. For example, scientists can insert a gene for GFP into a cell or organism, allowing them to visualize the cell or protein in real-time using a fluorescent microscope. This can be particularly useful in studying the development and function of cells, as well as in the diagnosis and treatment of diseases. GFPs have also been used to develop biosensors, which can detect the presence of specific molecules or changes in cellular environment. For example, researchers have developed GFP-based sensors that can detect the presence of certain drugs or toxins, or changes in pH or calcium levels within cells. Overall, GFPs have become a valuable tool in the medical field, allowing researchers to study cellular processes and diseases in new and innovative ways.

In the medical field, "cell survival" refers to the ability of cells to survive and continue to function despite exposure to harmful stimuli or conditions. This can include exposure to toxins, radiation, or other forms of stress that can damage or kill cells. Cell survival is an important concept in many areas of medicine, including cancer research, where understanding how cells survive and resist treatment is crucial for developing effective therapies. In addition, understanding the mechanisms that regulate cell survival can also have implications for other areas of medicine, such as tissue repair and regeneration.

Nerve degeneration refers to the progressive loss of function and structure of a nerve over time. This can occur due to a variety of factors, including injury, disease, or aging. Nerve degeneration can lead to a range of symptoms, depending on which nerves are affected and the severity of the degeneration. Common symptoms of nerve degeneration include pain, numbness, weakness, and tingling sensations. In some cases, nerve degeneration can lead to more serious complications, such as muscle atrophy or paralysis. Treatment for nerve degeneration typically involves addressing the underlying cause of the degeneration, as well as managing symptoms and preventing further damage to the affected nerves.

In the medical field, an axon is a long, slender projection of a nerve cell (neuron) that conducts electrical impulses away from the cell body towards other neurons, muscles, or glands. The axon is covered by a myelin sheath, which is a fatty substance that insulates the axon and helps to speed up the transmission of electrical signals. Axons are responsible for transmitting information throughout the nervous system, allowing the brain and spinal cord to communicate with other parts of the body. They are essential for many bodily functions, including movement, sensation, and cognition. Damage to axons can result in a variety of neurological disorders, such as multiple sclerosis, Guillain-Barré syndrome, and peripheral neuropathy. Treatments for these conditions often focus on preserving and regenerating axons to restore normal function.

In the medical field, "age factors" refer to the effects of aging on the body and its various systems. As people age, their bodies undergo a variety of changes that can impact their health and well-being. These changes can include: 1. Decreased immune function: As people age, their immune system becomes less effective at fighting off infections and diseases. 2. Changes in metabolism: Aging can cause changes in the way the body processes food and uses energy, which can lead to weight gain, insulin resistance, and other metabolic disorders. 3. Cardiovascular changes: Aging can lead to changes in the heart and blood vessels, including increased risk of heart disease, stroke, and high blood pressure. 4. Cognitive changes: Aging can affect memory, attention, and other cognitive functions, which can lead to conditions such as dementia and Alzheimer's disease. 5. Joint and bone changes: Aging can cause changes in the joints and bones, including decreased bone density and increased risk of osteoporosis and arthritis. 6. Skin changes: Aging can cause changes in the skin, including wrinkles, age spots, and decreased elasticity. 7. Hormonal changes: Aging can cause changes in hormone levels, including decreased estrogen in women and decreased testosterone in men, which can lead to a variety of health issues. Overall, age factors play a significant role in the development of many health conditions and can impact a person's quality of life. It is important for individuals to be aware of these changes and to take steps to maintain their health and well-being as they age.

The cerebellopontine angle (CPA) is a region of the brain located at the base of the skull, where the cerebellum and pons meet. It is also known as the posterior fossa or the posterior cranial fossa. The CPA is a critical area of the brain that contains several important structures, including the eighth cranial nerve (the vestibulocochlear nerve), which is responsible for hearing and balance, and the trigeminal nerve, which is responsible for sensation in the face. The CPA is also home to several blood vessels and lymph nodes. In the medical field, the CPA is often studied in the context of disorders that affect these structures, such as acoustic neuromas, meningiomas, and schwannomas.

Hypertensive encephalopathy is a medical condition that occurs when high blood pressure (hypertension) causes damage to the brain. It is a type of stroke that occurs when the blood vessels in the brain become narrowed or blocked, leading to a lack of oxygen and nutrients to the brain cells. This can cause a range of symptoms, including headache, confusion, difficulty speaking or understanding speech, weakness or numbness in the face, arms, or legs, and vision problems. In severe cases, hypertensive encephalopathy can lead to seizures, coma, and even death. Treatment typically involves lowering blood pressure to normal levels as quickly as possible, as well as addressing any underlying causes of hypertension.

Ocular motility disorders refer to a group of conditions that affect the movement of the eyes. These disorders can be caused by a variety of factors, including damage to the nerves or muscles that control eye movement, problems with the brain's ability to coordinate eye movements, or abnormalities in the shape or position of the eyes or orbit. Symptoms of ocular motility disorders can include double vision, difficulty tracking objects with the eyes, limited ability to move the eyes in certain directions, and a sensation of the eyes being stuck or unable to move. These symptoms can be caused by a variety of conditions, including muscle weakness or paralysis, nerve damage, or problems with the brain's control of eye movement. Diagnosis of ocular motility disorders typically involves a comprehensive eye examination, including tests of eye movement and coordination, as well as imaging studies such as MRI or CT scans. Treatment options for ocular motility disorders depend on the underlying cause and may include medications, physical therapy, or surgery. In some cases, corrective lenses or other optical aids may also be helpful in improving vision and reducing symptoms.

The cerebral aqueduct is a narrow channel located in the brainstem that connects the third ventricle to the fourth ventricle. It is also known as the aqueduct of Sylvius, after the French anatomist who first described it in the 17th century. The cerebral aqueduct is an important part of the brain's cerebrospinal fluid (CSF) circulation system. CSF is a clear, colorless fluid that circulates throughout the brain and spinal cord, providing nutrients and removing waste products. The CSF is produced in the choroid plexuses of the ventricles and flows through the cerebral aqueduct to the fourth ventricle, where it is absorbed into the bloodstream. The cerebral aqueduct is a tight, narrow channel that is only about 1 millimeter wide in most places. It is surrounded by a layer of connective tissue called the arachnoid mater, which helps to protect and support the aqueduct. The aqueduct is also lined with ependymal cells, which are specialized cells that help to regulate the flow of CSF through the channel. Damage or blockage of the cerebral aqueduct can lead to a condition called aqueductal stenosis, which can cause an accumulation of CSF in the brain and lead to hydrocephalus, a condition characterized by an abnormal increase in the pressure within the brain. Hydrocephalus can cause a range of symptoms, including headache, nausea, vomiting, confusion, and loss of consciousness. Treatment for aqueductal stenosis and hydrocephalus may involve the placement of a shunt, a tube that is placed in the brain to drain excess CSF from the brain to another part of the body where it can be absorbed.

In the medical field, cognition refers to the mental processes involved in acquiring, processing, and using information. It encompasses a wide range of mental functions, including perception, attention, memory, language, problem-solving, and decision-making. Cognitive abilities are essential for daily functioning and can be affected by various medical conditions, such as brain injuries, neurological disorders, and mental illnesses. In medical settings, cognitive assessments are often used to evaluate a patient's cognitive abilities and diagnose any underlying conditions that may be affecting them. Cognitive therapy is also a type of psychotherapy that focuses on improving cognitive processes to alleviate symptoms of mental health conditions such as depression, anxiety, and post-traumatic stress disorder (PTSD).

Transcription factors are proteins that regulate gene expression by binding to specific DNA sequences and controlling the transcription of genetic information from DNA to RNA. They play a crucial role in the development and function of cells and tissues in the body. In the medical field, transcription factors are often studied as potential targets for the treatment of diseases such as cancer, where their activity is often dysregulated. For example, some transcription factors are overexpressed in certain types of cancer cells, and inhibiting their activity may help to slow or stop the growth of these cells. Transcription factors are also important in the development of stem cells, which have the ability to differentiate into a wide variety of cell types. By understanding how transcription factors regulate gene expression in stem cells, researchers may be able to develop new therapies for diseases such as diabetes and heart disease. Overall, transcription factors are a critical component of gene regulation and have important implications for the development and treatment of many diseases.

Horseradish Peroxidase (HRP) is an enzyme that is commonly used in medical research and diagnostics. It is a protein that catalyzes the oxidation of a wide range of substrates, including hydrogen peroxide, which is a reactive oxygen species that is produced by cells as a byproduct of metabolism. In medical research, HRP is often used as a label for antibodies or other molecules, allowing researchers to detect the presence of specific proteins or other molecules in tissues or cells. This is done by first attaching HRP to an antibody or other molecule of interest, and then using a substrate that reacts with HRP to produce a visible signal. This technique is known as immunohistochemistry or immunofluorescence. HRP is also used in diagnostic tests, such as pregnancy tests, where it is used to detect the presence of specific hormones or other molecules in urine or blood samples. In these tests, HRP is attached to an antibody that binds to the target molecule, and the presence of the target molecule is detected by the production of a visible signal. Overall, HRP is a versatile enzyme that is widely used in medical research and diagnostics due to its ability to catalyze the oxidation of a wide range of substrates and its ability to be easily labeled and detected.

Cerebrospinal fluid (CSF) is a clear, colorless liquid that surrounds and protects the brain and spinal cord. It is produced by the choroid plexuses, which are specialized structures located in the ventricles of the brain. CSF serves several important functions in the body, including: 1. Providing cushioning and support for the brain and spinal cord 2. Maintaining the proper pressure within the skull and spinal canal 3. Removing waste products and excess fluids from the brain and spinal cord 4. Protecting the brain and spinal cord from injury CSF is constantly being produced and absorbed by the body, and its composition and pressure can provide important clues about the health of the brain and spinal cord. In some cases, problems with the production, absorption, or circulation of CSF can lead to serious medical conditions, such as hydrocephalus or meningitis.

Glioblastoma is a type of brain tumor that is classified as a grade IV astrocytoma, which means it is a highly aggressive and rapidly growing cancer. It is the most common and deadly type of primary brain tumor in adults, accounting for about 15% of all brain tumors. Glioblastoma typically arises from the supportive cells of the brain called astrocytes, but it can also develop from other types of brain cells. The tumor is characterized by its ability to infiltrate and spread into the surrounding brain tissue, making it difficult to remove completely through surgery. Symptoms of glioblastoma can vary depending on the location of the tumor in the brain, but common symptoms include headaches, seizures, nausea, vomiting, memory loss, and changes in personality or behavior. Treatment for glioblastoma typically involves a combination of surgery, radiation therapy, and chemotherapy. Despite these treatments, glioblastoma is generally considered to be incurable, with a median survival rate of about 15 months from diagnosis.

A brain concussion is a type of traumatic brain injury (TBI) that occurs when the brain is jolted or shaken inside the skull. This can happen when the head is hit, struck, or shaken violently, causing the brain to bounce around inside the skull. The symptoms of a brain concussion can vary widely and may include headache, dizziness, confusion, memory loss, nausea, vomiting, sensitivity to light and sound, and changes in mood or behavior. In some cases, a person may also experience temporary loss of consciousness or amnesia. Concussions are a common type of TBI, and they can occur in a variety of settings, including sports, car accidents, falls, and assaults. It is important to seek medical attention if you suspect that you or someone else may have suffered a concussion, as untreated concussions can lead to long-term complications and even permanent brain damage. Treatment typically involves rest, pain management, and monitoring for any signs of worsening symptoms.

Homeodomain proteins are a class of transcription factors that play a crucial role in the development and differentiation of cells and tissues in animals. They are characterized by a highly conserved DNA-binding domain called the homeodomain, which allows them to recognize and bind to specific DNA sequences. Homeodomain proteins are involved in a wide range of biological processes, including embryonic development, tissue differentiation, and organogenesis. They regulate the expression of genes that are essential for these processes by binding to specific DNA sequences and either activating or repressing the transcription of target genes. There are many different types of homeodomain proteins, each with its own unique function and target genes. Some examples of homeodomain proteins include the Hox genes, which are involved in the development of the body plan in animals, and the Pax genes, which are involved in the development of the nervous system. Mutations in homeodomain proteins can lead to a variety of developmental disorders, including congenital malformations and intellectual disabilities. Understanding the function and regulation of homeodomain proteins is therefore important for the development of new treatments for these conditions.

Hydrocephalus is a medical condition characterized by the accumulation of cerebrospinal fluid (CSF) within the brain, leading to increased pressure within the skull. This pressure can cause damage to the brain and result in a range of symptoms, including headache, nausea, vomiting, blurred vision, difficulty walking, and cognitive impairment. Hydrocephalus can be caused by a variety of factors, including brain injury, infection, tumors, genetic disorders, and bleeding in the brain. Treatment typically involves the insertion of a shunt, which is a tube that drains excess CSF from the brain to another part of the body where it can be absorbed or eliminated. In some cases, surgery may be necessary to remove the underlying cause of the hydrocephalus or to repair damage to the brain or spinal cord.

Body temperature refers to the internal temperature of an organism, typically measured in degrees Celsius (°C) or Fahrenheit (°F). In humans, the normal body temperature is generally considered to be around 36.5-37.5°C (97.7-99.5°F) when measured orally, rectally, or under the arm. Body temperature is regulated by the hypothalamus, a part of the brain that acts as the body's thermostat. The hypothalamus receives information about the body's internal temperature from sensors located throughout the body, and then initiates responses to either increase or decrease the body's temperature as needed to maintain homeostasis. Changes in body temperature can be caused by a variety of factors, including physical activity, environmental conditions, illness, and medication. Fever, which is an elevation of body temperature above the normal range, can be a sign of infection or other underlying medical conditions and is typically treated with medication to reduce the fever.

Cerebrovascular disorders refer to conditions that affect the blood vessels in the brain, leading to a disruption in blood flow and oxygen supply to the brain tissue. These disorders can be caused by a variety of factors, including atherosclerosis (hardening and narrowing of the arteries), high blood pressure, diabetes, smoking, and genetic factors. Cerebrovascular disorders can be classified into two main categories: ischemic and hemorrhagic. Ischemic cerebrovascular disorders are caused by a lack of blood flow to the brain, which can result from a blockage or narrowing of the blood vessels. Hemorrhagic cerebrovascular disorders, on the other hand, are caused by bleeding in the brain, which can result from a ruptured blood vessel or an aneurysm. Some common examples of cerebrovascular disorders include stroke, transient ischemic attack (TIA), and aneurysm. Stroke is a type of cerebrovascular disorder that occurs when blood flow to the brain is completely blocked or reduced, leading to brain damage or death. TIA, also known as a mini-stroke, is a temporary disruption in blood flow to the brain that usually lasts only a few minutes. An aneurysm is a bulge in a blood vessel in the brain that can rupture and cause bleeding. Cerebrovascular disorders can have serious consequences, including disability, cognitive impairment, and even death. Treatment options for these disorders depend on the underlying cause and the severity of the condition. Early detection and prompt medical intervention are crucial for improving outcomes and reducing the risk of complications.

In the medical field, cell movement refers to the ability of cells to move from one location to another within a tissue or organism. This movement can occur through various mechanisms, including crawling, rolling, and sliding, and is essential for many physiological processes, such as tissue repair, immune response, and embryonic development. There are several types of cell movement, including: 1. Chemotaxis: This is the movement of cells in response to chemical gradients, such as the concentration of a signaling molecule. 2. Haptotaxis: This is the movement of cells in response to physical gradients, such as the stiffness or topography of a substrate. 3. Random walk: This is the movement of cells in a seemingly random manner, which can be influenced by factors such as cell adhesion and cytoskeletal dynamics. 4. Amoeboid movement: This is the movement of cells that lack a well-defined cytoskeleton and rely on changes in cell shape and adhesion to move. Understanding cell movement is important for many medical applications, including the development of new therapies for diseases such as cancer, the study of tissue regeneration and repair, and the design of new materials for tissue engineering and regenerative medicine.

Central nervous system (CNS) diseases refer to disorders that affect the brain and spinal cord. These diseases can be caused by a variety of factors, including genetic mutations, infections, injuries, and degenerative processes. Some common examples of CNS diseases include: 1. Neurodegenerative diseases: These are disorders that cause the progressive loss of brain cells and function, leading to cognitive decline and physical disability. Examples include Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. Infections: Infections caused by viruses, bacteria, fungi, or parasites can affect the brain and spinal cord, leading to a range of symptoms such as fever, headache, seizures, and paralysis. 3. Trauma: Traumatic injuries to the brain and spinal cord, such as those caused by car accidents, falls, or sports injuries, can result in a range of neurological symptoms. 4. Genetic disorders: Some genetic disorders can affect the development and function of the brain and spinal cord, leading to a range of symptoms such as intellectual disability, movement disorders, and seizures. 5. Autoimmune disorders: Autoimmune disorders, such as multiple sclerosis, can cause inflammation and damage to the myelin sheath that surrounds nerve fibers in the brain and spinal cord, leading to a range of neurological symptoms. Overall, CNS diseases can have a significant impact on a person's quality of life and can be challenging to diagnose and treat.

Seizures are abnormal electrical discharges in the brain that can cause a variety of symptoms, including convulsions, muscle spasms, loss of consciousness, and changes in behavior or sensation. Seizures can be caused by a variety of factors, including brain injury, infection, genetic disorders, and certain medications. They can be classified into different types based on their symptoms and the part of the brain affected. Treatment for seizures may include medications, surgery, or other interventions, depending on the underlying cause and severity of the seizures.

Ophthalmoplegia is a medical condition characterized by weakness or paralysis of the muscles that control eye movement. It can affect one or both eyes and can be caused by a variety of factors, including injury, infection, inflammation, or neurological disorders. Symptoms of ophthalmoplegia may include double vision, difficulty moving the eyes, drooping eyelids, and loss of vision. Treatment for ophthalmoplegia depends on the underlying cause and may include medications, surgery, or physical therapy.

A Colony-Forming Units (CFU) Assay is a method used to determine the number of viable bacterial cells present in a sample. The assay involves plating a known volume of the sample onto a solid growth medium and incubating the plate for a specific period of time. The number of colonies that grow on the plate is then counted and used to calculate the number of CFUs per milliliter of the original sample. This information is important in the medical field for monitoring the effectiveness of antibiotics, assessing the quality of water and food, and diagnosing and tracking the spread of bacterial infections.

Tyrosine 3-monooxygenase (T3MO) is an enzyme that plays a role in the metabolism of tyrosine, an amino acid that is a precursor to many important molecules in the body, including neurotransmitters, hormones, and melanin. T3MO catalyzes the conversion of tyrosine to 3,4-dihydroxyphenylalanine (DOPA), which is then converted to dopamine, norepinephrine, and epinephrine by other enzymes. T3MO is primarily found in the brain and adrenal gland, and it is involved in the regulation of mood, motivation, and stress response. Abnormalities in T3MO activity have been linked to a number of neurological and psychiatric disorders, including depression, anxiety, and schizophrenia.

Leigh disease is a rare, inherited disorder that affects the nervous system. It is caused by a deficiency in an enzyme called pyruvate dehydrogenase (PDH), which is involved in the metabolism of fatty acids and glucose. This deficiency leads to the accumulation of toxic byproducts in the brain and spinal cord, causing damage to the nerve cells and leading to a range of symptoms. The symptoms of Leigh disease can vary widely depending on the age of onset and the severity of the deficiency. Common symptoms include developmental delays, muscle weakness, difficulty with coordination and balance, seizures, and vision and hearing problems. In some cases, the disease can also affect the heart and lungs. Leigh disease is usually diagnosed in infancy or early childhood, although it can occur at any age. It is inherited in an autosomal recessive pattern, which means that a child must inherit two copies of the mutated gene (one from each parent) in order to develop the disease. There is no cure for Leigh disease, and treatment is focused on managing the symptoms and providing supportive care.

Neuropeptides are small, protein-like molecules that are synthesized and secreted by neurons in the nervous system. They play a variety of roles in regulating and modulating various physiological processes, including mood, appetite, pain perception, and hormone release. Neuropeptides are typically composed of 3-50 amino acids and are synthesized in the endoplasmic reticulum of neurons. They are then transported to the synaptic terminals, where they are released into the synaptic cleft and bind to specific receptors on the postsynaptic neuron or on other cells in the body. There are many different types of neuropeptides, each with its own unique structure and function. Some examples of neuropeptides include dopamine, serotonin, and opioid peptides such as endorphins. Neuropeptides can act as neurotransmitters, neuromodulators, or hormones, and they play important roles in both the central and peripheral nervous systems.

Tetrodotoxin (TTX) is a potent neurotoxin that is produced by certain species of marine animals, including pufferfish, cone snails, and some species of sea slugs. TTX is a colorless, odorless, and tasteless compound that is highly toxic to humans and other animals. In the medical field, TTX is primarily used as a research tool to study the function of voltage-gated sodium channels, which are essential for the transmission of nerve impulses. TTX blocks these channels, leading to a loss of electrical activity in nerve cells and muscles. TTX has also been used in the treatment of certain medical conditions, such as chronic pain and epilepsy. However, its use in humans is limited due to its toxicity and the difficulty in administering it safely. In addition to its medical uses, TTX has also been used as a pesticide and a tool for controlling invasive species. However, its use as a pesticide is controversial due to its potential toxicity to non-target organisms and its persistence in the environment.

Meningoencephalitis is a medical condition that refers to the inflammation of both the meninges, which are the protective membranes that surround the brain and spinal cord, and the brain itself. This inflammation can be caused by a variety of factors, including viral or bacterial infections, autoimmune disorders, or certain medications. Symptoms of meningoencephalitis can include fever, headache, nausea and vomiting, sensitivity to light, confusion, seizures, and changes in mental status. In severe cases, meningoencephalitis can lead to coma or even death. Diagnosis of meningoencephalitis typically involves a combination of physical examination, medical history, and laboratory tests, such as blood tests, cerebrospinal fluid analysis, and imaging studies like MRI or CT scans. Treatment for meningoencephalitis depends on the underlying cause and can include antiviral or antibiotic medications, corticosteroids to reduce inflammation, and supportive care to manage symptoms and prevent complications. In some cases, hospitalization and intensive care may be necessary.

In the medical field, algorithms are a set of step-by-step instructions used to diagnose or treat a medical condition. These algorithms are designed to provide healthcare professionals with a standardized approach to patient care, ensuring that patients receive consistent and evidence-based treatment. Medical algorithms can be used for a variety of purposes, including diagnosing diseases, determining the appropriate course of treatment, and predicting patient outcomes. They are often based on clinical guidelines and best practices, and are continually updated as new research and evidence becomes available. Examples of medical algorithms include diagnostic algorithms for conditions such as pneumonia, heart attack, and cancer, as well as treatment algorithms for conditions such as diabetes, hypertension, and asthma. These algorithms can help healthcare professionals make more informed decisions about patient care, improve patient outcomes, and reduce the risk of medical errors.

Encephalitis, viral refers to an inflammation of the brain caused by a viral infection. The virus can affect any part of the brain, but it most commonly affects the temporal lobe, which is responsible for memory and speech. Symptoms of viral encephalitis can include fever, headache, nausea, vomiting, confusion, seizures, and changes in behavior or personality. In severe cases, it can lead to coma or even death. Treatment typically involves antiviral medications, supportive care, and rehabilitation to help manage symptoms and improve outcomes.

Ataxia is a medical condition characterized by a lack of coordination and balance, resulting in difficulty with movement and stability. It can affect various parts of the body, including the arms, legs, speech, and gait. Ataxia can be caused by a variety of factors, including genetic disorders, brain injuries, infections, toxins, and degenerative diseases such as multiple sclerosis, Huntington's disease, and Parkinson's disease. The severity of ataxia can vary widely, ranging from mild to severe, and it can impact a person's ability to perform daily activities and may require medical treatment and rehabilitation.

Cell- and tissue-based therapy, also known as regenerative medicine, is a medical approach that involves the use of cells, tissues, or organs to repair or replace damaged or diseased tissues in the body. This approach is based on the principle that cells have the ability to divide and differentiate into different types of cells, which can be used to regenerate damaged tissues. Cell-based therapy involves the use of cells, such as stem cells, to repair or replace damaged tissues. Stem cells are undifferentiated cells that have the ability to differentiate into different types of cells, such as muscle cells, nerve cells, or blood cells. Stem cells can be obtained from various sources, including embryos, adult tissues, and umbilical cord blood. Tissue-based therapy involves the use of tissues, such as skin, bone, or cartilage, to repair or replace damaged tissues. Tissue engineering is a technique used to create functional tissues in the laboratory by combining cells, scaffolds, and growth factors. These engineered tissues can then be implanted into the body to replace damaged or diseased tissues. Cell- and tissue-based therapy has the potential to treat a wide range of medical conditions, including heart disease, diabetes, spinal cord injuries, and cancer. However, this approach is still in the early stages of development, and more research is needed to fully understand its potential benefits and risks.

In the medical field, infarction refers to the death of tissue due to a lack of blood supply. This can occur in various organs, including the heart, brain, lungs, and kidneys. In the case of a heart infarction, also known as a heart attack, the lack of blood supply to the heart muscle can cause damage or death to the affected area. This is typically caused by a blockage in one of the coronary arteries, which supply blood to the heart. In the case of a brain infarction, also known as a stroke, the lack of blood supply to the brain can cause damage or death to brain tissue. This is typically caused by a blockage in a blood vessel that supplies blood to the brain. In the case of a lung infarction, the lack of blood supply to the lung tissue can cause damage or death to the affected area. This is typically caused by a blockage in a blood vessel that supplies blood to the lung. In the case of a kidney infarction, the lack of blood supply to the kidney tissue can cause damage or death to the affected area. This is typically caused by a blockage in a blood vessel that supplies blood to the kidney.

Brain tissue transplantation is a medical procedure in which healthy brain tissue is transplanted into a patient's brain to replace damaged or diseased tissue. This procedure is typically used to treat neurological disorders such as Parkinson's disease, Huntington's disease, and multiple sclerosis. The transplantation process involves removing healthy brain tissue from a donor, typically a brain-dead individual, and then surgically implanting it into the patient's brain. The transplanted tissue can either be used to replace damaged tissue in a specific area of the brain or to provide a source of healthy cells that can help to regenerate damaged tissue. While brain tissue transplantation has shown promise in preclinical studies, it is still a relatively new and experimental procedure, and there are many challenges associated with its use in humans. These challenges include finding suitable donors, ensuring that the transplanted tissue is properly matched to the patient, and preventing rejection of the transplanted tissue by the patient's immune system.

Coculture techniques refer to the process of growing two or more different cell types together in a single culture dish or flask. This is commonly used in the medical field to study interactions between cells, such as how cancer cells affect normal cells or how immune cells respond to pathogens. Coculture techniques can be used in a variety of ways, including co-culturing cells from different tissues or organs, co-culturing cells with different cell types, or co-culturing cells with microorganisms or other foreign substances. Coculture techniques can also be used to study the effects of drugs or other treatments on cell interactions. Overall, coculture techniques are a valuable tool in the medical field for studying cell interactions and developing new treatments for diseases.

Amyloid beta (Aβ) peptides are a group of proteins that are produced as a normal byproduct of metabolism in the brain. They are formed from the cleavage of a larger protein called amyloid precursor protein (APP) by enzymes called beta-secretase and gamma-secretase. In healthy individuals, Aβ peptides are cleared from the brain by a process called phagocytosis, in which immune cells called microglia engulf and degrade the peptides. However, in individuals with Alzheimer's disease (AD), the clearance of Aβ peptides is impaired, leading to the accumulation of these peptides in the brain. The accumulation of Aβ peptides in the brain is thought to play a key role in the development of AD. The peptides can form insoluble aggregates called amyloid plaques, which are a hallmark of AD. These plaques can disrupt the normal functioning of neurons and contribute to the cognitive decline associated with the disease. In addition to their role in AD, Aβ peptides have also been implicated in other neurological disorders, such as Parkinson's disease and frontotemporal dementia.

The amygdala is a small almond-shaped structure located deep within the temporal lobes of the brain. It is part of the limbic system, which is responsible for regulating emotions, memory, and behavior. The amygdala plays a crucial role in processing emotions, particularly fear and anxiety. It receives sensory information from the thalamus and evaluates it for potential threats or danger. If a threat is detected, the amygdala sends signals to other parts of the brain, such as the hypothalamus and the brainstem, to initiate a fight-or-flight response. The amygdala is also involved in the formation and retrieval of emotional memories. It helps to consolidate emotional memories and store them in long-term memory, which can be important for learning from past experiences and avoiding similar situations in the future. In addition to its role in emotion regulation and memory, the amygdala is also involved in other functions, such as social behavior, decision-making, and addiction. Damage to the amygdala can result in a range of emotional and behavioral problems, including anxiety disorders, depression, and aggression.

Natriuretic Peptide, Brain (NPB) is a hormone that is produced by the brain and released into the bloodstream. It is a member of the natriuretic peptide family, which also includes atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). NPB has several functions in the body, including regulating blood pressure, fluid balance, and heart rate. It works by inhibiting the release of renin, a hormone that stimulates the production of angiotensin II, which in turn constricts blood vessels and increases blood pressure. NPB also has a role in the regulation of the autonomic nervous system, which controls heart rate and blood pressure. It can stimulate the release of nitric oxide, a molecule that helps to relax blood vessels and lower blood pressure. In the medical field, NPB is being studied as a potential diagnostic tool for various cardiovascular diseases, including heart failure and hypertension. It may also have therapeutic potential for these conditions, as it has been shown to improve cardiac function and reduce blood pressure in animal models.

Denervation refers to the loss of nerve supply to a particular tissue or organ. This can occur due to various reasons such as injury, disease, or surgical removal of the nerve. When a tissue or organ is denervated, it loses its ability to receive signals from the nervous system, which can lead to a range of symptoms and complications. In the medical field, denervation can have significant implications for the diagnosis and treatment of various conditions. For example, denervation of the muscles can lead to muscle weakness or paralysis, while denervation of the heart can lead to arrhythmias or other cardiac problems. In some cases, denervation may be reversible with appropriate treatment, while in other cases it may be permanent.

Nitric Oxide Synthase Type I (NOS1) is an enzyme that is responsible for the production of nitric oxide (NO) in the body. NO is a gas that plays a crucial role in various physiological processes, including vasodilation, neurotransmission, and immune function. NOS1 is primarily expressed in neurons and is involved in the regulation of synaptic transmission and neurotransmitter release. It is also expressed in immune cells, where it plays a role in the regulation of inflammation and immune responses. Abnormalities in NOS1 function have been implicated in a number of diseases, including neurodegenerative disorders, cardiovascular disease, and cancer. Therefore, understanding the regulation and function of NOS1 is important for the development of new therapeutic strategies for these diseases.

An autopsy is a medical examination of a dead body to determine the cause of death. It involves a thorough examination of the body, including internal organs and tissues, to identify any signs of disease, injury, or other conditions that may have contributed to the person's death. During an autopsy, the body is typically opened and the organs and tissues are removed and examined under a microscope or other specialized equipment. The pathologist who performs the autopsy will also take samples of tissue and fluids for further analysis in the laboratory. Autopsies can be performed for a variety of reasons, including to determine the cause of death in cases where the death was unexpected or unexplained, to investigate criminal or suspicious deaths, or to provide information for medical research. They are an important tool for advancing medical knowledge and improving public health.

Vestibulocochlear nerve diseases refer to disorders that affect the vestibulocochlear nerve, which is also known as the eighth cranial nerve. This nerve is responsible for transmitting signals from the inner ear to the brain, allowing us to hear and maintain balance. Vestibulocochlear nerve diseases can affect either the hearing portion of the nerve (cochlear) or the balance portion of the nerve (vestibular). Some common vestibulocochlear nerve diseases include: 1. Meniere's disease: This is a disorder that affects the inner ear and can cause symptoms such as hearing loss, ringing in the ears (tinnitus), vertigo, and a feeling of fullness in the ear. 2. Acoustic neuroma: This is a benign tumor that grows on the vestibulocochlear nerve and can cause symptoms such as hearing loss, ringing in the ears, and vertigo. 3. Labyrinthitis: This is an inflammation of the inner ear that can cause symptoms such as hearing loss, vertigo, and ringing in the ears. 4. Vestibular neuronitis: This is an inflammation of the vestibular nerve that can cause symptoms such as vertigo, dizziness, and nausea. Treatment for vestibulocochlear nerve diseases depends on the specific disorder and its severity. In some cases, medications or lifestyle changes may be sufficient to manage symptoms. In more severe cases, surgery may be necessary to remove a tumor or repair damage to the nerve.

Glycine is an amino acid that is essential for the proper functioning of the human body. It is a non-essential amino acid, meaning that the body can synthesize it from other compounds, but it is still important for various physiological processes. In the medical field, glycine is used as a dietary supplement to support muscle growth and recovery, as well as to improve sleep quality. It is also used in the treatment of certain medical conditions, such as liver disease, as it can help to reduce the buildup of toxins in the liver. Glycine is also used in the production of various medications, including antibiotics and tranquilizers. It has been shown to have a calming effect on the nervous system and may be used to treat anxiety and other mental health conditions. Overall, glycine is an important nutrient that plays a vital role in many physiological processes in the body.

Cell division is the process by which a single cell divides into two or more daughter cells. This process is essential for the growth, development, and repair of tissues in the body. There are two main types of cell division: mitosis and meiosis. Mitosis is the process by which somatic cells (non-reproductive cells) divide to produce two identical daughter cells with the same number of chromosomes as the parent cell. This process is essential for the growth and repair of tissues in the body. Meiosis, on the other hand, is the process by which germ cells (reproductive cells) divide to produce four genetically diverse daughter cells with half the number of chromosomes as the parent cell. This process is essential for sexual reproduction. Abnormalities in cell division can lead to a variety of medical conditions, including cancer. In cancer, cells divide uncontrollably and form tumors, which can invade nearby tissues and spread to other parts of the body.

Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate (WGA-HRP) is a laboratory reagent used in medical research and diagnostics. It is a combination of two molecules: Wheat Germ Agglutinin (WGA) and Horseradish Peroxidase (HRP). WGA is a protein found in wheat seeds that binds to specific carbohydrates on the surface of cells. HRP is an enzyme that catalyzes the conversion of hydrogen peroxide into water and oxygen, producing a colored reaction product that can be detected and measured. When WGA-HRP conjugate is used in medical research, it is often applied to tissue samples or cells to visualize specific structures or markers. The WGA portion of the conjugate binds to the carbohydrate structures on the surface of the cells or tissue, while the HRP portion catalyzes the production of a colored reaction product that can be visualized under a microscope. In diagnostics, WGA-HRP conjugate is used in immunoassays to detect specific antigens or antibodies in biological samples. The conjugate is applied to a test strip or slide, and if the target antigen or antibody is present in the sample, it will bind to the WGA portion of the conjugate. The HRP portion of the conjugate will then catalyze the production of a colored reaction product, which can be detected and quantified. Overall, WGA-HRP conjugate is a valuable tool in medical research and diagnostics, allowing researchers and clinicians to visualize and detect specific structures and markers in cells and tissues.

Aspartate-tRNA ligase is an enzyme that plays a crucial role in protein synthesis. It is responsible for attaching the amino acid aspartate to its corresponding transfer RNA (tRNA) molecule. This process is known as aminoacylation and is a critical step in the translation of genetic information from messenger RNA (mRNA) into a protein. During aminoacylation, aspartate-tRNA ligase uses energy from ATP to bind the amino acid aspartate to the 3' end of the tRNA molecule. This reaction is highly specific and ensures that the correct amino acid is attached to the correct tRNA molecule, which is essential for the proper assembly of proteins. Aspartate-tRNA ligase is a member of the aminoacyl-tRNA synthetase family of enzymes, which are responsible for attaching all 20 amino acids to their corresponding tRNA molecules. Deficiencies or mutations in aspartate-tRNA ligase can lead to various genetic disorders, including aspartyluria, which is a rare inherited disorder characterized by the accumulation of aspartic acid in the urine and blood.

Pentobarbital is a barbiturate medication that is primarily used as a sedative, hypnotic, and anesthetic. It is a short-acting drug that is often used for the treatment of insomnia, anxiety, and seizures. Pentobarbital is also used as an anesthetic for minor surgical procedures and for the induction of general anesthesia in combination with other anesthetic agents. It is available in both oral and injectable forms and is typically administered by a healthcare professional. Pentobarbital can cause drowsiness, dizziness, and other side effects, and it may interact with other medications. It is a controlled substance and is regulated by the government to prevent abuse and misuse.

Subarachnoid hemorrhage (SAH) is a medical condition that occurs when blood leaks into the space between the arachnoid mater and the pia mater, which are two layers of tissue that cover the surface of the brain. This can happen due to a ruptured aneurysm, which is a bulge in a blood vessel in the brain that can burst and cause bleeding. SAH is a serious medical emergency that requires prompt diagnosis and treatment. The symptoms of SAH can include severe headache, nausea and vomiting, sensitivity to light, confusion, and loss of consciousness. If left untreated, SAH can lead to brain damage, stroke, and even death. Treatment for SAH typically involves surgery to repair or remove the ruptured aneurysm, as well as medications to manage symptoms and prevent further bleeding. The prognosis for SAH depends on several factors, including the severity of the bleeding, the location of the aneurysm, and the patient's overall health.

In the medical field, the term "cattle" refers to large domesticated animals that are raised for their meat, milk, or other products. Cattle are a common source of food and are also used for labor in agriculture, such as plowing fields or pulling carts. In veterinary medicine, cattle are often referred to as "livestock" and may be treated for a variety of medical conditions, including diseases, injuries, and parasites. Some common medical issues that may affect cattle include respiratory infections, digestive problems, and musculoskeletal disorders. Cattle may also be used in medical research, particularly in the fields of genetics and agriculture. For example, scientists may study the genetics of cattle to develop new breeds with desirable traits, such as increased milk production or resistance to disease.

The cerebellar nuclei are a group of nuclei located in the center of the cerebellum, a part of the brain that plays a crucial role in motor control, coordination, and balance. The cerebellar nuclei receive input from various parts of the brain and spinal cord, including the cerebral cortex, brainstem, and spinal cord, and send output to the thalamus and brainstem. The cerebellar nuclei are composed of several subnuclei, including the dentate nucleus, the globose nucleus, the emboliform nucleus, and the fastigial nucleus. Each of these subnuclei has a specific function and receives input from different regions of the brain. Damage to the cerebellar nuclei can result in a range of neurological symptoms, including ataxia (loss of coordination and balance), tremors, and difficulty with speech and swallowing. The cerebellar nuclei are also involved in cognitive functions such as attention, memory, and language processing.

In the medical field, blinking refers to the rapid closing and opening of the eyelids. Blinking is a natural reflex that helps to keep the eyes lubricated and protected from dust, debris, and other foreign objects. It also helps to distribute tears evenly over the surface of the eye, which helps to maintain clear vision. Blinking is an important aspect of eye health and can be affected by a variety of factors, including eye strain, dry eye syndrome, and certain medical conditions such as blepharospasm or myasthenia gravis. In some cases, blinking may be reduced or absent due to neurological disorders or injuries to the facial muscles. In medical settings, blinking can be monitored and evaluated as part of a comprehensive eye examination. This can help to identify any underlying issues that may be affecting the function of the eyelids or the overall health of the eyes.

Membrane proteins are proteins that are embedded within the lipid bilayer of a cell membrane. They play a crucial role in regulating the movement of substances across the membrane, as well as in cell signaling and communication. There are several types of membrane proteins, including integral membrane proteins, which span the entire membrane, and peripheral membrane proteins, which are only in contact with one or both sides of the membrane. Membrane proteins can be classified based on their function, such as transporters, receptors, channels, and enzymes. They are important for many physiological processes, including nutrient uptake, waste elimination, and cell growth and division.

The corpus striatum is a part of the brain that plays a crucial role in movement control, reward processing, and cognitive functions. It is located in the basal ganglia, a group of subcortical nuclei in the brain that are involved in a wide range of functions, including motor control, learning, and memory. The corpus striatum is composed of two main structures: the caudate nucleus and the putamen. These structures are interconnected and work together to process information and coordinate movement. The corpus striatum receives input from various parts of the brain, including the cerebral cortex, thalamus, and cerebellum, and sends output to other parts of the brain, including the globus pallidus and substantia nigra. Damage to the corpus striatum can result in a range of movement disorders, such as Parkinson's disease, Huntington's disease, and dystonia. It can also affect cognitive functions, such as learning and memory, and can lead to behavioral and emotional changes.

Cord Blood Stem Cell Transplantation (CBSC Transplantation) is a medical procedure that involves the transplantation of stem cells from a donor's umbilical cord blood into a patient who has a damaged or diseased bone marrow or blood system. The stem cells are collected from the umbilical cord blood after a baby is born and are then cryopreserved for future use. CBSC transplantation is used to treat a variety of conditions, including leukemia, lymphoma, myelodysplastic syndrome, and sickle cell disease. The procedure is typically performed in a hospital setting and involves the administration of high-dose chemotherapy or radiation to the patient's bone marrow and blood system to destroy the diseased cells. The cryopreserved stem cells are then infused into the patient's bloodstream, where they can engraft and repopulate the patient's bone marrow and blood system with healthy, functioning cells. CBSC transplantation is considered a less invasive and less toxic alternative to traditional bone marrow transplantation, as it does not require the collection of stem cells from the patient's bone marrow or the use of a matched donor. However, the success of CBSC transplantation depends on the availability of a suitable donor and the patient's overall health and medical condition.

In the medical field, "Brain Diseases, Metabolic" refers to a group of disorders that affect the brain's metabolism, which is the process by which the brain uses nutrients to produce energy and maintain its normal functions. These disorders can result from a variety of causes, including genetic mutations, hormonal imbalances, and nutritional deficiencies. Some examples of metabolic brain diseases include: 1. Alpers-Huttenlocher syndrome: A rare genetic disorder that affects the metabolism of certain fatty acids in the brain, leading to progressive brain damage and seizures. 2. Maple syrup urine disease: A genetic disorder that affects the metabolism of certain amino acids, leading to a sweet-smelling urine and neurological symptoms. 3. Phenylketonuria (PKU): A genetic disorder that affects the metabolism of the amino acid phenylalanine, leading to intellectual disability and other neurological problems if left untreated. 4. Leigh syndrome: A genetic disorder that affects the metabolism of certain fatty acids in the brain, leading to progressive neurological symptoms and often death in childhood. 5. Wilson's disease: A genetic disorder that affects the metabolism of copper, leading to liver and neurological damage. Treatment for metabolic brain diseases often involves dietary changes, supplements, and medications to correct the underlying metabolic abnormality. In some cases, a liver transplant may be necessary to remove excess copper in Wilson's disease.

Apoptosis is a programmed cell death process that occurs naturally in the body. It is a vital mechanism for maintaining tissue homeostasis and eliminating damaged or unwanted cells. During apoptosis, cells undergo a series of changes that ultimately lead to their death and removal from the body. These changes include chromatin condensation, DNA fragmentation, and the formation of apoptotic bodies, which are engulfed by neighboring cells or removed by immune cells. Apoptosis plays a critical role in many physiological processes, including embryonic development, tissue repair, and immune function. However, when apoptosis is disrupted or dysregulated, it can contribute to the development of various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.

The baroreflex is a complex physiological mechanism that helps regulate blood pressure and maintain cardiovascular homeostasis. It involves a reflex arc that involves the stretch receptors in the walls of the aorta and carotid arteries, which detect changes in blood pressure, and the central nervous system, which responds to these changes by adjusting heart rate and blood vessel tone. When blood pressure increases, the stretch receptors in the aorta and carotid arteries are activated, which sends signals to the brainstem. The brainstem then sends signals to the heart to decrease its rate and to the blood vessels to dilate, which reduces resistance and allows more blood to flow through the body, thereby lowering blood pressure. Conversely, when blood pressure decreases, the stretch receptors are deactivated, and the brainstem sends signals to the heart to increase its rate and to the blood vessels to constrict, which increases resistance and helps raise blood pressure. The baroreflex is a critical mechanism for maintaining blood pressure within a narrow range and preventing cardiovascular disease. It is also involved in other physiological processes, such as the regulation of breathing and the control of body temperature.

Biogenic amines are organic compounds that are produced by living organisms, including humans. They are derived from amino acids and are involved in a variety of physiological processes, including neurotransmission, hormone release, and regulation of blood pressure. In the medical field, biogenic amines are often studied in relation to various diseases and disorders. For example, high levels of certain biogenic amines, such as dopamine and norepinephrine, have been linked to conditions such as Parkinson's disease and hypertension. On the other hand, low levels of certain biogenic amines, such as serotonin, have been associated with depression and anxiety disorders. In addition, biogenic amines are also used as diagnostic tools in medical testing. For example, the measurement of levels of certain biogenic amines in the blood or urine can be used to help diagnose and monitor certain diseases, such as pheochromocytoma (a tumor of the adrenal gland) or carcinoid syndrome (a condition caused by the overproduction of certain hormones). Overall, biogenic amines play important roles in many physiological processes and are the subject of ongoing research in the medical field.

The cerebellar cortex is the outer layer of the cerebellum, a part of the brain that plays a crucial role in motor coordination, balance, and posture. It is composed of several layers of neurons that receive and process information from various parts of the brain and body, and then send signals to the spinal cord and muscles to control movement. The cerebellar cortex is divided into several regions, each of which is responsible for controlling different aspects of movement. For example, the anterior lobe of the cerebellum is involved in controlling movements of the arms and hands, while the posterior lobe is involved in controlling movements of the legs and trunk. Damage to the cerebellar cortex can result in a range of movement disorders, including ataxia (lack of coordination), tremors, and difficulty with balance and posture. These disorders can be caused by a variety of factors, including genetic mutations, infections, and head injuries.

Hearing disorders refer to any condition that affects an individual's ability to perceive sound. These disorders can range from mild to severe and can be caused by a variety of factors, including genetics, aging, exposure to loud noises, infections, and certain medical conditions. Some common types of hearing disorders include: 1. Conductive hearing loss: This type of hearing loss occurs when sound waves cannot pass through the outer or middle ear properly. Causes of conductive hearing loss include ear infections, earwax buildup, and damage to the eardrum or middle ear bones. 2. Sensorineural hearing loss: This type of hearing loss occurs when there is damage to the inner ear or the auditory nerve. Causes of sensorineural hearing loss include aging, exposure to loud noises, certain medications, and genetic factors. 3. Mixed hearing loss: This type of hearing loss occurs when there is a combination of conductive and sensorineural hearing loss. 4. Auditory processing disorder: This type of hearing disorder affects an individual's ability to process and interpret sounds. It can cause difficulties with speech and language development, as well as problems with reading and writing. 5. Tinnitus: This is a condition characterized by a ringing, buzzing, or hissing sound in the ears. It can be caused by a variety of factors, including exposure to loud noises, ear infections, and certain medications. Treatment for hearing disorders depends on the type and severity of the condition. Some common treatments include hearing aids, cochlear implants, and medications to manage symptoms such as tinnitus. In some cases, surgery may be necessary to correct structural problems in the ear.

Cognition disorders refer to a group of conditions that affect an individual's ability to think, reason, remember, and learn. These disorders can be caused by a variety of factors, including brain injury, neurological disorders, genetic factors, and aging. Cognition disorders can manifest in different ways, depending on the specific area of the brain that is affected. For example, a person with a memory disorder may have difficulty remembering important information, while someone with a language disorder may have trouble expressing themselves or understanding what others are saying. Some common types of cognition disorders include: 1. Alzheimer's disease: A progressive neurological disorder that affects memory, thinking, and behavior. 2. Dementia: A general term used to describe a decline in cognitive function that is severe enough to interfere with daily life. 3. Delirium: A sudden onset of confusion and disorientation that can be caused by a variety of factors, including illness, medication side effects, or dehydration. 4. Aphasia: A language disorder that affects a person's ability to speak, understand, or use language. 5. Attention deficit hyperactivity disorder (ADHD): A neurodevelopmental disorder that affects a person's ability to focus, pay attention, and control impulses. 6. Learning disorders: A group of conditions that affect a person's ability to acquire and use knowledge and skills. Cognition disorders can have a significant impact on a person's quality of life, and treatment options may include medication, therapy, and lifestyle changes. Early diagnosis and intervention are important for managing these conditions and improving outcomes.

A brain stem tumor is a tumor in the part of the brain that connects to the spinal cord (the brain stem). The symptoms of brain ... http://neurosurgery.mgh.harvard.edu/abta/primer.htm[full citation needed] Brainstem Gliomas~treatment at eMedicine Brain stem ... The most common form of brainstem tumor is the brainstem glioma. Treatment typically consists of radiotherapy and steroids for ... Headaches related to brainstem tumors may be worse shortly after waking up in the morning. An MRI is better than a CT scan when ...
The brainstem (or brain stem) is the stalk-like: 152 part of the brain that interconnects the cerebrum and diencephalon with ... 3D visualization of the brainstem in an average human brain Triune brain - reptilian brain Haines, D; Mihailoff, G (2018). ... In the human brain the brainstem is composed of the midbrain, the pons, and the medulla oblongata.: 152 The midbrain is ... "Cranial Nerve Nuclei and Brain Stem Circulation". Neuroanatomy Online. Retrieved 2020-05-13. Kolb, B. & Whishaw, I. Q. (2009). ...
Are 'brain dead' (or 'brain stem dead') patients neurologically recoverable? In Finis Vitae - 'brain death' is not true death. ... Pallis, C. From Brain Death to Brain Stem Death, BMJ, 285, November 1982 Coimbra CG. Implications of ischemic penumbra for the ... ABC of brain stem death. BMJ Publishing Group, 1996, p.30 Shewmon DA. 'Brain body' disconnection : implications for the ... The demise of 'brain death' in Britain. In Beyond brain death - the case against brain based criteria for human death. Eds. ...
The Childhood Brain Tumor Foundation. 23 Oct. 2008. "Brain Stem Gliomas." Brain Tumor Society. 25 Oct. 2008. "Brain Stem Glioma ... "Brain Stem Gliomas in Childhood." Brain Tumor Types and Imaging. ... "Immunotherapy for Patients With Brain Stem Glioma and ... is the main diagnostic tool for brain stem gliomas. In very rare cases, surgery and biopsy are performed. Unlike most brain ... A brainstem glioma is a cancerous glioma tumor in the brainstem. Around 75% are diagnosed in children and young adults under ...
Moore, Ernest J (1983). Bases of auditory brain stem evoked responses. New York: Grune & Stratton. ISBN 978-0-8089-1465-5. OCLC ... Long, K.J.; Allen, N. (October 1984). "Abnormal brain-stem auditory evoked potentials following Ondine's curse". Arch. Neurol. ... Brain Research. Don M, Kwong B, Tanaka C (2012). "Interaural stacked auditory brainstem response measures for detecting small ... The auditory brainstem response (ABR), also called brainstem evoked response audiometry (BERA), is an auditory evoked potential ...
Bickerstaff ER (1957). "Brain-stem encephalitis: further observations on a grave syndrome with benign prognosis". Br Med J. 1 ( ... Brain. OUP. 126 (10): 2279-90. doi:10.1093/brain/awg233. PMID 12847079. Odaka, et al, 2003, "Bickerstaff's brainstem ... "Orphanet: Bickerstaff brainstem encephalitis". www.orpha.net. Retrieved 28 October 2019. "Bickerstaff's Brainstem Encephalitis ... Bickerstaff brainstem encephalitis is a rare inflammatory disorder of the central nervous system, first described by Edwin ...
Long, KJ; Allen, N (October 1984). "Abnormal brain-stem auditory evoked potentials following Ondine's curse". Archives of ... In human neuroanatomy, brainstem auditory evoked potentials (BAEPs), also called brainstem auditory evoked responses (BAERs), ... These investigators hypothesized that their patient's brainstem was poisoned, but not destroyed, by her chronic alcoholism. ... and inferior colliculus of the brainstem. They typically have a response latency of no more than six milliseconds with an ...
Yang et al (1987). A developmental study of bone-conduction auditory brain stem response in infants. Ear & Hearing; 8, 4. ... Bone-conduction auditory brainstem response (BCABR) are similar to air conduction auditory brainstem responses, with the main ... Auditory brain stem evoked responses to bone-conducted signals. Archives of Otolaryngology; 105, 656-661. ... Bone-conduction auditory brainstem response or BCABR is a type of auditory evoked response that records neural response from ...
"Brain Stem Death". Gender Justice Uncovered Awards. Women's Link Worldwide. Retrieved 13 June 2017. Judgments: P.P -v- Health ... The cause was a large cerebellar cystic lesion causing acute hydrocephalus and compression of brain stem. She was placed on ... McDonald, Henry (26 December 2014). "Brain-dead pregnant woman's life support can be switched off, Irish court rules". The ... Carolan, Mary (11 April 2016). "Judgment on brain-dead pregnant woman wins award". The Irish Times. Retrieved 13 June 2017. " ...
Bickerstaff ER (June 1957). "Brain-stem encephalitis; further observations on a grave syndrome with benign prognosis". British ... Brain 1986; 109: 1115-1126". Brain. 139 (7): 2096-2100. doi:10.1093/brain/aww127. Asbury AK, Cornblath DR (1990). "Assessment ... Brain. 130 (Pt 9): 2245-57. doi:10.1093/brain/awm004. PMID 17337484. Darweesh SK, Polinder S, Mulder MJ, Baena CP, van Leeuwen ... Brain 1969; 92: 589-606; with An acute axonal form of Guillain-Barré polyneuropathy by T.E. Feasby, J.J. Gilbert, W.F. Brown, C ...
Bickerstaff, E.R. (15 June 1957). "Brain-stem encephalitis; further observations on a grave syndrome with benign prognosis". ...
"Paraneoplastic brain stem encephalitis". Current Treatment Options in Neurology. 15 (2): 201-209. doi:10.1007/s11940-013-0221-1 ... brainstem encephalitis, opsoclonus myoclonus ataxia syndrome, anti-NMDA receptor encephalitis, and polymyositis. The following ... The purpose of this exploration was to shed light on immunotherapies and distinguishing between neurotoxicity and brain ...
Deep dissection of brain-stem. Lateral view. Dissection of brain-stem. Lateral view. Dissection of brain-stem. Dorsal view. ... The fibers continue to course through the medulla oblongata of the brainstem, at which point they pass through the inferior ... ISBN 978-1-58890-572-7. Cooke, J. D. (October 1971). "Origin and termination of cuneocerebellar tract". Experimental Brain ... Superficial dissection of brain-stem. Lateral view. ...
... is yellow) Superficial dissection of brain-stem. Lateral view. Dissection of brain-stem. Lateral view. Scheme ... The fibers from the retina run along the optic nerve to nine primary visual nuclei in the brain, from which a major relay ... The optic nerve on MRI Stained brain slice images which include the "optic%20nerve" at the BrainMaps project IFOND online case ... Optic nerve Optic nerve Human brain dura mater (reflections) Optic nerve Optic nerve Optic nerve Cerebrum.Inferior view.Deep ...
Thalamus Deep dissection of brain-stem. Lateral view. Deep dissection of brain-stem. Lateral view. Dissection of brain-stem. ... Brainstem. Posterior view. Buffalo.edu at the Library of Congress Web Archives (archived 2001-11-27) Brainconnection.com at the ...
It sends fibers to deep cerebellar nuclei that, in turn, project to both the cerebral cortex and the brain stem, thus providing ... Brainstem. Posterior view. Midsagittal view Lobules of the vermis. Coffman, K.A.; Dum, R.P.; Strick, P.L. (2011). "Cerebellar ... It is also commonly associated with dysplasias of brainstem nuclei. DWM has been reported to be in association with a wide ... S.K. Clarren; J. Alvord; S.M. Sumi (1978). "Brain malformations related to prenatal exposure to ethanol". Journal of Pediatrics ...
Superficial dissection of brain-stem. Lateral view. Deep dissection of brain-stem. Lateral view. Dissection of brain-stem. ... Brainstem. Posterior view. Auditory system List of regions in the human brain Shore, S. E.: Auditory/Somatosensory Interactions ... Stained brain slice images which include the "inferior colliculus" at the BrainMaps project NIF Search - Brachium of inferior ... This indicates that the inferior colliculus is metabolically more active than many other parts of the brain. The hippocampus, ...
Superficial dissection of brain-stem. Lateral view. Superficial dissection of brain-stem. Ventral view. Dissection of brain- ... stem. Dorsal view. External capsule External capsule Ventricles of brain and basal ganglia. Superior view. Horizontal section. ... The external capsule is a series of white matter fiber tracts in the brain. These fibers run between the most lateral (toward ... Ventricles of brain and basal ganglia.Superior view. Horizontal section. Deep dissection. Internal capsule Extreme capsule ...
Superficial dissection of brain-stem. Ventral view. Transverse section through mid-brain Section of brain showing upper surface ... Schematic representation of the chief ganglionic categories (I to V) Dissection of brain-stem. Lateral view. ... Deep dissection Ventricles of brain and basal ganglia. Superior view. Horizontal section. Deep dissection Striatum This article ... section of brain immediately in front of pons Coronal section through anterior cornua of lateral ventricles Ventricles of brain ...
Brain stem involvement is common. Depression, weakness, head tilt, and dysphagia also occur. S. fayeri may cause myositis in ... Garnham, P. C. C.; Duggan, A. J.; Sinden, R. E. (1979). "A new species of Sarcocystis in the brain of two exotic birds". ... This genus was distinguished from Sarcocystis on the basis of its tendency to encyst within the brain rather than within muscle ...
Scheme showing the connections of the several parts of the brain. Superficial dissection of brain-stem. Lateral view. Hind- and ... The middle cerebellar peduncle (or brachium pontis) is a paired structure of the brain. It connects the pons to the cerebellum ... Basal view of a human brain Dissection of human midbrain with middle cerebellar peduncle labeled. Cross section through lower ...
Deep dissection of brain-stem. Lateral view. Deep dissection of brain-stem. Ventral view. Dissection of brain-stem. Dorsal view ... Dissection of brain-stem. Lateral view. Deep dissection of brain-stem. Lateral view. ... Coronal section through mid-brain. Transverse section of mid-brain at level of inferior colliculi. Scheme showing the course of ... The lateral lemniscus is a tract of axons in the brainstem that carries information about sound from the cochlear nucleus to ...
Superficial dissection of brain-stem. Ventral view. Hind- and mid-brains; postero-lateral view. Figure showing the mode of ... before exiting the brainstem at the pontomedullary junction.[citation needed] The abducens nerve emerges from the brainstem at ... A right-sided brain tumor can produce either a right-sided or a left-sided sixth nerve palsy as an initial sign. Thus a right- ... ISBN 978-0-8089-2371-8. Dura mater and its processes exposed by removing part of the right half of the skull, and the brain. ...
Brain-Stem Localization and Function. Springer Science & Business Media. ISBN 9783642781728. Schmidt, D.; Thoden, U. (1978-06- ... Findings in normals and patients with brainstem lesions". Brain. 116 (3): 727-738. doi:10.1093/brain/116.3.727. ISSN 0006-8950 ... According to (Urban 1993), "In patients with brainstem disease abnormal transverse auricular muscle coactivation is ...
Thalamus Dissection of brain-stem. Lateral view. Scheme showing central connections of the optic nerves and optic tracts. ... Regions in the brainstem that are not involved in visual perception also project to the LGN, such as the mesencephalic ... Stained brain slice images which include the "lateral%20geniculate%20nucleus" at the BrainMaps project Atlas image: eye_38 at ... In humans as well as other mammals, the two strongest pathways linking the eye to the brain are those projecting to the dorsal ...
Brain stem sagittal section "Trochlear , Definition of Trochlear by Oxford Dictionary on Lexico.com also meaning of Trochlear ... Cytoarchitecture of the Human Brain Stem (2nd ed.). Basel: S. Karger. pp. 50-51. ISBN 3-8055-2210-X. Atlas image: n2a4p4 at the ... in the midbrain before emerging from the brainstem posteriorly/dorsally.[citation needed] In other words, trochlear nucleus on ... University of Michigan Health System - "Brainstem, Cranial Nerve Nuclei, Sagittal Section, Medial View" v t e (Articles with ...
Deep dissection of brain-stem. Ventral view. Superior terminations of the posterior fasciculi of the medulla spinalis. This ... Unlike other ascending tracts of the brain, fibres of the medial lemniscus do not give off collateral branches as they travel ... along the brainstem. The fibres that make up the sensory decussation are responsible for fine touch, proprioception and two- ...
Brain stem: Tumors on the brainstem can cause seizures, endocrine problems, respiratory changes, visual changes, headaches and ... Most brain tumors have higher ADC than normal brain tissues and doctors can match the observed ADC of the patient's brain tumor ... White British brain tumour patients 'more likely to die in a year' The Guardian "Quick Brain Tumor Facts". National Brain Tumor ... Brain Tumor Nervous system neoplasm List of brain tumor cases "Adult Brain Tumors Treatment". NCI. 28 February 2014. Archived ...
"First stem cell brain surgery". Hindustan Times. 3 January 2009. Archived from the original on 5 February 2015. Retrieved 4 ... He is known to have introduced microdialysis of brain and stem cell therapy for cerebral palsy for the first time in Asia. ... Stereotactic surgery Deep brain stimulation Stem cell therapy Cerebral palsy Parkinson's disease India portal Medicine portal " ... The magazine "Brain Voice" is yet another initiative to create awareness about brain, spine, spirituality and related issues to ...
Dorsal column-medial lemniscus pathway Deep dissection of brain-stem. Lateral view. Deep dissection of brain-stem. Ventral view ... Fibres from these nuclei will pass to the contralateral side of the brainstem, as the internal arcuate fibres. At the open ... Transverse section of mid-brain at level of inferior colliculi. Scheme showing the course of the fibers of the lemniscus; ... Diffusion tensor tractography of the somatosensory system in the human brainstem: initial findings using high isotropic spatial ...
A brain stem tumor is a tumor in the part of the brain that connects to the spinal cord (the brain stem). The symptoms of brain ... http://neurosurgery.mgh.harvard.edu/abta/primer.htm[full citation needed] Brainstem Gliomas~treatment at eMedicine Brain stem ... The most common form of brainstem tumor is the brainstem glioma. Treatment typically consists of radiotherapy and steroids for ... Headaches related to brainstem tumors may be worse shortly after waking up in the morning. An MRI is better than a CT scan when ...
Broken heart syndrome may be linked to the brain. ... Broken-Heart Syndrome May Stem from the Brain. News By Yasemin ... The brain scans were compared with another 39 brain scans, taken in patients without broken-heart syndrome. The researchers ... Broken-heart syndrome "clearly involves interactions between the brain and the heart," Ghardi said. It is "in fact a brain- ... The brain scans took place in 2013 and 2014; patients had been diagnosed, on average, about a year before the scan. The scans ...
The brain stem controls vital bodily functions, including breathing and heartbeat. Thus, a brain stem stroke is a life- ... The way a stroke affects the brain depends on which part of the brain suffers damage, and to what degree. ... A stroke occurs when blood supply to the brain is interrupted. ... Were dependent on brain stem function for survival. A brain ... All of the signals from your brain move through the brain stem to reach the different parts of your body. Nerve cells that come ...
A stroke affecting the brain stem is potentially life threatening since this area of the brain controls functions such as ... Brain stem stroke may also cause double vision, nausea and loss of coordination. The brain stem also controls less essential ... A stroke affecting the brain stem is potentially life threatening since this area of the brain controls functions such as ... Brain stem stroke may also cause double ...
Although various systems are used to classify these tumors, the authors have divided brainstem gliomas into 3 distinct anatomic ... Brainstem gliomas are tumors that occur in the region of the brain referred to as the brain stem, which is the area between the ... Brainstem gliomas are tumors that occur in the region of the brain referred to as the brain stem, which is the area between the ... As the name implies, brainstem gliomas occur in the region of the brain stem. Approximately 60% of the time they are centered ...
Scientists have created a way to isolate neural stem cells †... Stem cell advance a step forward for treatment of brain ... They used the virus to deliver the synthetic DNA to neural stem cells in the brain tissue. The technique compelled neural stem ... These stem cells can renew themselves and have the potential to become a number of brain cell types - for instance, ... Scientists have created a way to isolate neural stem cells - cells that give rise to all the cell types of the brain - from ...
Quinones-Hinojosas Brain Tumor Stem Cell Research Lab at Mayo Clinic explores glioblastoma therapies, cell migration & ... Projects in the Brain Tumor Stem Cell Research Lab investigate the effect of ion transporters in brain tumor cell migration and ... Using fat to fight cancer. The Brain Tumor Stem Cell Research Lab at Mayo Clinic engineers human mesenchymal stem cells with ... The Brain Tumor Stem Cell Research Laboratory has created a human tissue bank to preserve tissue and cell cultures for use in ...
A deep dive into the science and impact of stem cells. ... Stem Cell Research. Stem Cells and Clinical Genomics for ... Brain Organoids and Robotics / AI - Sanford Stem Cell Symposium. 2/20/2022; 88 minutos ... Stem Cells and Clinical Genomics for Clinical Trials in Dish - Breaking News in Stem Cells. ...
... discusses an NIH-sponsored study investigating the effectiveness of an auditory brain stem implant in young children with ... PODCAST: Auditory brain stem implants in young children.. January 14, 2016. Podcast ... Jamie Glater, MD, discusses an NIH-sponsored study investigating the effectiveness of an auditory brain stem implant in young ... Pediatrics about a National Institutes of Health-sponsored study investigating the effectiveness of an auditory brain stem ...
Astrocytic Tumors Brain Stem Gliomas Treatment of brain stem gliomas may include the following: Radiation therapy . Use ... ... General Information About Childhood Brain Stem Glioma Key Points for This Section Childhood brain stem ... ... Childhood Brain Stem Glioma Treatment (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf ... Childhood Brain Stem Glioma Treatment (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf ...
Stem Cell Protocol Investigated For Brain Trauma 01-23-2012. • arclein n numerous studies, stem cell implantation has ... SEX ON THE BRAIN Sex can help protect against dementia - heres how much youll need to have. Donna Hancock ... Light therapy helps the brain clear out toxic Alzheimers proteins. Robert Lee ... substantially improved brain function in experimental animals with brain trauma. But just how these improvements occur has ...
Meningioma Stem Cells. This entry was posted in Research Projects on October 13, 2009. by brainscience. ... Johnsons laboratory is working to determine whether cancer stem cells exist in meningiomas. His goal is to isolate these cells ... Studies in several cancers (including brain, breast, prostate, ovarian, skin) suggest that only a small fraction of the cells ... These tumor-initiating cells (also called cancer stem cells) are thought to be responsible for tumor development and recurrence ...
The idea that new nerve cells can grow in adult brains forms the basis of current research into stem cell therapy. However, not ... If these stem cells could be delivered to the damaged part of the brain, maybe they would divide and specialise, replenishing ... Implications for stem cell research. Suddenly, scientists could see the potential for using newly dividing brain cells to treat ... The field of stem cell research was opened wide.. Written by Sara Loughnane, NZ Science, Mathematics, and Technology Teacher ...
So I figured if I could activate the entire stem in the same way, my inner vision would multiply in power. And oh yes, they ... If any of you know how I can help calm and program my brainstem to be tranquil and peaceful, Id love to hear about it, but I ... Brainstem activation: Overwhelming and even frightening!. Ive been trying to activate my pineal gland for about six years now ... If you cant stop your brain from doing these things, then youre not in charge. Its like putting your foot down on the pedal ...
brain researchcognitive scienceGeneticsgliaMultiple SclerosisneurobiologyNeurogeneticsoligodendrocytessciencespinal cordstem ... A First: Brain Support Cells from Umbilical Cord Stem Cells: For the first time ever, stem cells from umbilical … http://t.co/ ... A First: Brain Support Cells from Umbilical Cord Stem Cells: For the first time ever, stem cells from umbilical … http://t.co/ ... A First: Brain Support Cells from Umbilical Cord Stem Cells: For the first time ever, stem cells from umbilical … http://t.co/ ...
A deep dive into the science and impact of stem cells. ... Brain Organoids and Robotics / AI - Sanford Stem Cell Symposium ... Rescuing Phenotypes in PTHS-Derived Brain Organoids with Alysson Muotri - Sanford Stem Cell Symposium 2022. 11/28/2022; 18 ... Alysson Muotri discusses modeling Pitt-Hopkins syndrome (PTHS) using stem cells and brain organoids. He shares how rescuing ... Stem Cells and Clinical Genomics for Clinical Trials in Dish - Breaking News in Stem Cells. ...
Brain Stem / chemistry* * Brain Stem / physiology * Immunoenzyme Techniques * Male * Microscopy, Electron * Neural Pathways / ... Contribution of brainstem GABAergic circuitry to descending antinociceptive controls: II. Electron microscopic ...
Trending / Cell & Molecular Biology / Might Alzheimers Disease Stem From a Brain Infection? ... The work builds on the idea that as the blood-brain barrier gets weak with age, it cant keep infections out. Aβ comes in to do ... Berislav Zlokovic, said his research on the blood-brain barrier would fit well with this new hypothesis. He discovered that as ... its work as an antimicrobial agent, but after the invader is killed, whats left behind damages the brain. This new research is ...
Cerebellum and Brain Stem Following Dietary Monosodium Glutamate Administration in Mice ... reduced in the brain stem and remained unchanged in the cerebellum. Catalase (CAT) activity in both the brain stem and the ... Lipid Peroxidation and Antioxidant Status of the Cerebrum, Cerebellum and Brain Stem Following Dietary Monosodium Glutamate ... Lipid Peroxidation and Antioxidant Status of the Cerebrum, Cerebellum and Brain Stem Following Dietary Monosodium Glutamate ...
Drugs stimulate bodys stem cells to replace the brain cells lost in multiple sclerosis. Print Email ... Home multiple sclerosis Drugs stimulate bodys stem cells to replace the brain cells lost in multiple sclerosis ... Two FDA approved drugs were found to stimulate stem cells in the brain and spinal cord to regenerate to the protective coating ... Stem Cell Therapy May Help Treat Multiple Sclerosis. on September 28, 2023 at 3:10 am New research finds a stem cell treatment ...
Brain Organoids and Robotics / AI - Sanford Stem Cell Symposium. 2/20/2022; 88 minutes ... Stem Cells and Clinical Genomics for Clinical Trials in Dish - Breaking News in Stem Cells. ... Studying the Brain Through the Lens of Neurodevelopmental Disorders with Gaia Novarino. ... One Niche to Rule Them All: Stem Cell-Lymphatic Interactome in Regeneration and Cancer ...
Researchers have discovered that a small cluster of neurons in the brain stem not only regulates tempo but also coordinates ... Researchers at UC San Francisco have discovered that a small cluster of neurons in the brain stem not only regulates tempo but ... The researchers then determined which cells in the brain stem were responsible for this rhythm, which turned out to be a ... Reference: Wei XP, Collie M, Dempsey B, Fortin G, Yackle K. A novel reticular node in the brainstem synchronizes neonatal mouse ...
Stem Cells and Disease Modeling in a Dish, Autism Research via Brain Organoids. 8/28/2020; 6 minutes ... In this excerpt Muotri discusses stem cell and brain organoid research for possible applications to human diseases. (#36301) ... Stem Cells and Clinical Genomics for Clinical Trials in Dish - Breaking News in Stem Cells. ... Studying the Brain Through the Lens of Neurodevelopmental Disorders with Gaia Novarino. ...
... from Russia with stem cells, MS, & more including recommended pub list ... Recommended reads: Bee brain, COVID, from Russia with stem cells, pubs. By Professor Paul Knoepfler, Ph.D. / Leave a Comment / ... Stem Cells, Generation of hypoimmunogenic human pluripotent stem cells via expression of membrane‐bound and secreted β2m‐HLA‐G ... Elizabeth Preston, NY Times, Meet a Bee With a Very Big Brain.This is a great read about brain evolution in general. ...
... report that they have discovered a way to stimulate neurons that are derived from human induced pluripotent stem cells (hiPSCs ... In a paper published online September 13th in Stem Cell Reports, Foundation 2013 NARSAD Distinguished Investigator Grantee ... Stem Cell Technology Offers New Insight into Brain Mechanisms Underlying Schizophrenia. Stem Cell Technology Offers New Insight ... "The significance of this study is that patient-derived stem cell neurons can uncover previously unknown neurotransmitter brain ...
A Youthful Brain Boost via DNA Hydroxymethylation: TET1 Enters the Myelin Repair Technicians Toolkit. December 13, 2021. ... Does it feel like your aging brain cells have been firing a little slower lately? Why not refresh your connection and speed up ... A Youthful Brain Boost via DNA Hydroxymethylation: TET1 Enters the Myelin Repair Technicians Toolkit ...
Stroke Stem Cell China, ALS Stem Cell China, Stem Cell Brain Trauma treatment China, PSP Stem Cell China, MSA Stem Cell China, ... Traumatic Brain Injury Stem Cell China, Cerebral Palsy Stem Cell China, ... Multiple Sclerosis Stem Cell China, Neurological Conditions Stem Cell China. ... Mediescapes India provides Info on Stem cell treatment center for Parkinson China, ...
Syrinx of the Spinal Cord or Brain Stem - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD ... Syringobulbia, which is rare, usually occurs as a slitlike gap within the lower brain stem and may disrupt or compress the ... Syringobulbia (a syrinx in the brain stem), which is rare, may cause vertigo, nystagmus, unilateral or bilateral loss of facial ... A syrinx is a fluid-filled cavity within the spinal cord (syringomyelia) or brain stem (syringobulbia). Predisposing factors ...
human mesenchymal stem cell, adult neurogenesis, dopaminergic neuron, tetrahedral amorphous carbon, carbon nanodiamond, brain ... Differentiation of Human Mesenchymal Stem Cells into Dopaminergic Neurons on Brain Electrode Materials. , Login ... Differentiation of Human Mesenchymal Stem Cells into Dopaminergic Neurons on Brain Electrode Materials. ... Differentiation of Human Mesenchymal Stem Cells into Dopaminergic Neurons on Brain Electrode Materials. Ihmisen ...
  • Scientists have created a way to isolate neural stem cells - cells that give rise to all the cell types of the brain - from human brain tissue with unprecedented precision, an important step toward developing new treatments for conditions of the nervous system, like Parkinson's and Huntington's diseases and spinal cord injury. (medicaldaily.com)
  • When it comes to the latest in stem cell healthcare, Tiantan Puhua Hospital doctors have developed a number of unprecedented and world leading stem cell treatment programs including 'Self stem cells Activation and Proliferation Program', neural stem cells implantation by Sterotacxios technique and Spinal Cord Stem Cell Injections. (mediescapes.com)
  • Autophagy in neural stem cells and glia for brain health and diseases. (bvsalud.org)
  • Autophagy facilities the utilization of energy and the microenvironment for developing neural stem cells . (bvsalud.org)
  • Autophagy also plays an indispensable role in the maintenance of stemness and homeostasis in neural stem cells during essential brain physiology and also in the instigation and progression of diseases . (bvsalud.org)
  • Thus, this review composes pertinent information regarding the involvement of autophagy in neural stem cells and glial regulation and the role of this connexion in normal brain functions, neurodevelopmental disorders , and neurodegenerative diseases . (bvsalud.org)
  • Nerve cells that come from various sections of the brain carry these signals right through the brain stem to the spinal cord. (healthline.com)
  • Dr. Quinones-Hinojosa's lab is studying ways to engineer human fat cells to turn them into cancer-fighting Trojan horses and evaluating a gel to locally administer to patients during brain cancer surgery. (mayo.edu)
  • The Brain Tumor Stem Cell Research Lab at Mayo Clinic engineers human mesenchymal stem cells with nanotechnology to serve as Trojan horses for the treatment of cancer. (mayo.edu)
  • Dr. Quinones-Hinojosa's lab is evaluating the efficacy of a gel for administering human fat-derived mesenchymal stem cells within the brain cancer resection cavity during surgery. (mayo.edu)
  • Summary: CD133 marks self-renewing cancer stem cells (CSCs) in a variety of solid tumors, and CD133+ tumor-initiating cells are known markers of chemo- and radio-resistance in multiple aggressive cancers, including glioblastoma (GBM), that may drive intra-tumoral heterogeneity. (weeksmd.com)
  • All three showed activity against patient-derived CD133+ GBM cells, and CART133 cells demonstrated superior efficacy in patient-derived GBM xenograft models without causing adverse effects on normal CD133+ hematopoietic stem cells in humanized CD34+ mice. (weeksmd.com)
  • The lab identified that the protein is a marker of cancer stem cells that have the properties necessary to grow glioblastoma tumours that are difficult to treat. (weeksmd.com)
  • They also looked at the safety of CD133-targeting therapies on normal, non-cancerous human stem cells including hematopoietic stem cells which create blood cells and progenitor cells which can form one or more kinds of cells. (weeksmd.com)
  • Studies in several cancers (including brain, breast, prostate, ovarian, skin) suggest that only a small fraction of the cells within each tumor is capable of giving rise to another tumor. (brainsciencefoundation.org)
  • These tumor-initiating cells (also called cancer stem cells) are thought to be responsible for tumor development and recurrence and have been shown to be more aggressive and resistant to therapy than the bulk of the cells within tumors. (brainsciencefoundation.org)
  • It is not known whether meningiomas contain such cancer stem cells. (brainsciencefoundation.org)
  • Dr. Johnson's laboratory is working to determine whether cancer stem cells exist in meningiomas. (brainsciencefoundation.org)
  • The idea that new nerve cells can grow in adult brains forms the basis of current research into stem cell therapy. (sciencelearn.org.nz)
  • At the time, few scientists believed that an adult brain could produce new cells. (sciencelearn.org.nz)
  • He suggested instead that the canary brain was making nerve cells in the regions where they were needed, causing that region to get larger, while the cells in other areas were sacrificed, and those regions got smaller. (sciencelearn.org.nz)
  • If these stem cells could be delivered to the damaged part of the brain, maybe they would divide and specialise, replenishing the damaged tissue and restoring people to good health. (sciencelearn.org.nz)
  • For the first time ever, stem cells from umbilical cords have been converted into other types of cells, which may eventually lead to new treatment options for spinal cord injuries and multiple sclerosis, among other nervous system diseases. (neurosciencenews.com)
  • This is the first time this has been done with non-embryonic stem cells," says James Hickman, a University of Central Florida bioengineer and leader of the research group, whose accomplishment is described in the Jan. 18 issue of the journal ACS Chemical Neuroscience . (neurosciencenews.com)
  • We're very excited about where this could lead because it overcomes many of the obstacles present with embryonic stem cells. (neurosciencenews.com)
  • Stem cells from umbilical cords do not pose an ethical dilemma because the cells come from a source that would otherwise be discarded. (neurosciencenews.com)
  • The pharmaceutical company Geron, based in Menlo Park, Calif., developed a treatment for spinal cord repair based on embryonic stem cells, but it took the company 18 months to get approval from the FDA for human trials due in large part to the ethical and public concerns tied to human embryonic stem cell research. (neurosciencenews.com)
  • The main challenge in working with stem cells is figuring out the chemical or other triggers that will convince them to convert into a desired cell type. (neurosciencenews.com)
  • When the new paper's lead author, Hedvika Davis, a postdoctoral researcher in Hickman's lab, set out to transform umbilical stem cells into oligodendrocytes-critical structural cells that insulate nerves in the brain and spinal cord-she looked for clues from past research. (neurosciencenews.com)
  • In early tests, she found that norepinephrine, along with other stem cell growth promoters, caused the umbilical stem cells to convert, or differentiate, into oligodendrocytes. (neurosciencenews.com)
  • We realized that the stem cells are very sensitive to environmental conditions," Davis said. (neurosciencenews.com)
  • Alysson Muotri discusses modeling Pitt-Hopkins syndrome (PTHS) using stem cells and brain organoids. (uctv.tv)
  • Two FDA approved drugs were found to stimulate stem cells in the brain and spinal cord to regenerate to the protective coating around neurons that is damaged in diseases such as multiple sclerosis. (innovationtoronto.com)
  • A pair of topical medicines already alleviating skin conditions may prove to have another, even more compelling use: instructing stem cells in the brain to reverse damage caused by multiple sclerosis. (innovationtoronto.com)
  • Led by researchers at Case Western Reserve University , a multi-institutional team used a new discovery approach to identify drugs that could activate mouse and human brain stem cells in the laboratory. (innovationtoronto.com)
  • The two most potent drugs-one that currently treats athlete's foot, and the other, eczema-were capable of stimulating the regeneration of damaged brain cells and reversing paralysis when administered systemically to animal models of multiple sclerosis. (innovationtoronto.com)
  • We know that there are stem cells throughout the adult nervous system that are capable of repairing the damage caused by multiple sclerosis, but until now, we had no way to direct them to act," said Paul Tesar, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics, and associate professor in the Department of Genetics & Genome Sciences at the Case Western Reserve School of Medicine. (innovationtoronto.com)
  • Our approach was to find drugs that could catalyze the body's own stem cells to replace the cells lost in multiple sclerosis. (innovationtoronto.com)
  • The disease is the most common chronic neurological disorder among young adults, and results from aberrant immune cells destroying the protective coating, called myelin, around nerve cells in the brain and spinal cord. (innovationtoronto.com)
  • To replace damaged cells, much of the stem cell field has focused on direct transplantation of stem cell-derived tissues for regenerative medicine, and that approach is likely to provide enormous benefit down the road," said Tesar, also a New York Stem Cell Foundation Robertson Investigator and member of the National Center for Regenerative Medicine . (innovationtoronto.com)
  • But here we asked if we could find a faster and less invasive approach by using drugs to activate native stem cells already in the adult nervous system and direct them to form new myelin. (innovationtoronto.com)
  • The researchers then determined which cells in the brain stem were responsible for this rhythm, which turned out to be a previously unknown circuit that appears to control the breath and coordinate the muscles needed to produce the vocal sounds. (technologynetworks.com)
  • Researcher Alysson Muotri is using stem cells to study everything from autism to the Zika virus. (ucsd.tv)
  • What are stem cells? (ipscell.com)
  • Reprogramming roadmap is interesting for the steps involved in induced pluripotency but also reveals route to human induced trophoblast stem cells. (ipscell.com)
  • In a paper published online September 13th in Stem Cell Reports , Foundation 2013 NARSAD Distinguished Investigator Grantee Vivian Hook, Ph.D. , and colleagues at the Salk Institute in La Jolla, California, report that they have discovered a way to stimulate neurons that are derived from human induced pluripotent stem cells (hiPSCs)-from the skin cells of patients with schizophrenia -to release neurotransmitters. (bbrfoundation.org)
  • In this study, Drs. Hook, Gage and colleagues created stem cells and then neurons in culture dishes using skin cells from three people with schizophrenia and compared them with three control subjects. (bbrfoundation.org)
  • Because in vivo human brain research is limited, hiPSC neurons derived from patients create new opportunities to understand changes in brain cells occurring in nervous system disorders. (bbrfoundation.org)
  • Does it feel like your aging brain cells have been firing a little slower lately? (epigenie.com)
  • Our senior staff of stem cells procedures is lead by Dr. Wu Li Ke and Dr. Wang Xiao Juan both have years of extensive stem cell research experience conducting clinical trials in China - Hebei Medical University. (mediescapes.com)
  • In charged of all stem cells operations is Dr. Han Xiao Di, who spent two years at Australia's Alfred Hospital in the neurosurgical department and in the Australia National Trauma Institute. (mediescapes.com)
  • Glial cells have attained relatively less consideration despite their unquestioned influence on various aspects of neural development, synaptic function, brain metabolism , cellular debris clearing, and restoration of damaged or injured tissues . (bvsalud.org)
  • Several avenues of investigation are being explored in Dr. Quinones-Hinojosa's Brain Tumor Stem Cell Research Laboratory at Mayo Clinic. (mayo.edu)
  • Researchers in the Brain Tumor Stem Cell Research Lab are investigating the oncostatic effects of melatonin on glioblastoma to improve treatment and provide better quality of life for patients. (mayo.edu)
  • Projects in the Brain Tumor Stem Cell Research Lab investigate the effect of ion transporters in brain tumor cell migration and the molecular engines that drive tumor invasion. (mayo.edu)
  • The Brain Tumor Stem Cell Research Lab studies genetic controls and mediators of tumor growth, invasion, and migration to understand how tumors move into the healthy brain. (mayo.edu)
  • The Brain Tumor Stem Cell Research Laboratory has created a human tissue bank to preserve tissue and cell cultures for use in present and future experiments. (mayo.edu)
  • This could have important implications for medulloblastoma, the most common pediatric brain tumor. (ipscell.com)
  • They account for about 20% of all pediatric primary brain tumors, but constitute less than 2% of all adult gliomas. (medscape.com)
  • Molecular, Pathological, Radiological, and Immune Profiling of Non- brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial. (nih.gov)
  • It turns out it is an article about going to Russia to get chemo and then hematopoietic stem cell transplant or HSCT for multiple sclerosis. (ipscell.com)
  • 0.05) in the cerebrum, reduced in the brain stem and remained unchanged in the cerebellum. (scialert.net)
  • 0.05) in the cerebellum but the antioxidants were not affected in the cerebrum and the brain stem. (scialert.net)
  • Dr. Quinones-Hinojosa's lab has research platforms on novel therapeutics for glioblastoma, cell migration and invasion, cellular therapy, and models of brain and spine cancers, and maintains a human tissue bank. (mayo.edu)
  • McMaster University Researchers of McMaster University and the University of Toronto have developed a promising immunotherapy treatment for a deadly form of adult brain cancer called glioblastoma. (weeksmd.com)
  • New projects related to aggressive brain cancers include research on nanodrug treatments and magnetic resonance-guided focused ultrasound for systemic therapy. (mayo.edu)
  • What is a brain stem stroke? (healthline.com)
  • A stroke occurs when blood supply to the brain is interrupted. (healthline.com)
  • The way a stroke affects the brain depends on which part of the brain suffers damage, and to what degree. (healthline.com)
  • A brain stem stroke threatens vital bodily functions, making it a life-threatening condition. (healthline.com)
  • Symptoms of stroke depend on which area of the brain is affected. (healthline.com)
  • A stroke in the brain stem can interfere with vital functions such as breathing and heartbeat. (healthline.com)
  • Brain stem stroke can also impair your speech and hearing, and cause vertigo. (healthline.com)
  • When blood flow in the brain stem is interrupted, such as with stroke, those brain signals are also disrupted. (healthline.com)
  • A brain stem stroke can cause you to lose your sense of smell and taste. (healthline.com)
  • A brain stem stroke is a life-threatening medical emergency. (healthline.com)
  • A stroke affecting the brain stem is potentially life threatening since this area of the brain controls functions such as breathing and instructing the heart to beat. (medlineplus.gov)
  • Brain stem stroke may also cause double vision, nausea and loss of coordination. (medlineplus.gov)
  • As a result of dependence upon higher brain centers, certain lesions or diseases of the brain (eg, stroke, cancer, dementia) can result in a loss of voluntary control of the normal micturition reflex as well as symptoms such as urinary urgency. (medscape.com)
  • PODCAST: Auditory brain stem implants in young children. (contemporarypediatrics.com)
  • Jamie Glater, MD, discusses an NIH-sponsored study investigating the effectiveness of an auditory brain stem implant in young children with congenital cochlear nerve agenesis. (contemporarypediatrics.com)
  • Jamie Glater, MD, assistant professor of clinical otolaryngology at the University of Southern California (USC) and faculty member at the USC Caruso Family Center for Childhood Communication, speaks with Contemporary Pediatrics about a National Institutes of Health-sponsored study investigating the effectiveness of an auditory brain stem implant in young children with congenital cochlear nerve agenesis. (contemporarypediatrics.com)
  • Auditory brainstem response is a response to external stimulation that represents the neural electrophysiological activity of the auditory system at the brainstem level. (bvsalud.org)
  • The Brainstem Auditory Evoked Response (BAEP) is a complex response to externalstimulation that represents the neural electrophysiological activity of the auditory system at the level of the brainstem, mapping the synapses of the auditory pathways from the cochlear nerve, cochlear nucleus, superior olivary brainstem complex to the inferior colliculus-midbrain 1,2 . (bvsalud.org)
  • His research was focused in enhancement of Neurogenesis after brain trauma under supervisory of Dr. Cristina Koshman and Prof. Jeffrey Rosenfeld. (mediescapes.com)
  • Neurons form connections in order to talk with one another and send signals across the brain. (livescience.com)
  • Researchers at UC San Francisco have discovered that a small cluster of neurons in the brain stem not only regulates tempo but also coordinates vocalization with breathing. (technologynetworks.com)
  • The significance of this study is that patient-derived stem cell neurons can uncover previously unknown neurotransmitter brain mechanisms occurring in schizophrenia," explains Dr. Hook. (bbrfoundation.org)
  • Now, a new study finds that the brain also appears to play a role: Researchers discovered that in people who develop broken-heart syndrome, areas of the brain responsible for controlling a person's stress response don't function as well as they do in people without broken-heart syndrome. (livescience.com)
  • The researchers found that people with the condition had fewer connections between brain regions associated with emotional processing and the autonomic nervous system - the apparatus that controls automatic processes in our bodies such as blinking and heartbeat. (livescience.com)
  • In addition, because the researchers don't have brain scans of the patients before they developed broken-heart syndrome, they can't say whether the decreased communication might be driving broken-heart syndrome or if the development of the syndrome is driving decreased communication in the brain. (livescience.com)
  • Tiantan Puhua (pronounced Tee En Tan [rhymes with Ron] Pooh Hwah) Hospital is proud to be home to many of not only Asia's, but the world's leading doctors and researchers in neurosurgery, and conducts well over 4,000 brain operations each year. (mediescapes.com)
  • Their stem cell experience has focused on the healing of brain trauma, spinal cord injury, cerebral vascular diseases, multiple sclerosis and myelitis, among other illnesses. (mediescapes.com)
  • During 1994-1995 in Louisiana, five cases of central nervous system trauma associated with riding bulls in rodeo events were identified through the Louisiana Central Nervous System Injury Registry, a statewide, population-based surveillance system addressing brain and spinal cord injury incidence, etiology, and outcome. (cdc.gov)
  • He sustained a brain stem contusion and an incomplete C2 spinal cord injury and was unconscious for 16 days. (cdc.gov)
  • n numerous studies, stem cell implantation has substantially improved brain function in experimental animals with brain trauma. (freedomsphoenix.com)
  • In this excerpt Muotri discusses stem cell and brain organoid research for possible applications to human diseases. (ucsd.tv)
  • This review will provide insight into establishing a concrete strategic approach for investigating pathological mechanisms and developing therapies for brain diseases . (bvsalud.org)
  • A syrinx is a fluid-filled cavity within the spinal cord (syringomyelia) or brain stem (syringobulbia). (msdmanuals.com)
  • All of the signals from your brain move through the brain stem to reach the different parts of your body. (healthline.com)
  • Neurotransmitters are chemicals that excite or inhibit the transmission of electrical signals through the brain and are crucial for brain function. (bbrfoundation.org)
  • When blood can't get to a section of the brain, the brain tissue in that area dies off because it's not receiving oxygen. (healthline.com)
  • A month later, the canaries were killed and their brain tissue examined. (sciencelearn.org.nz)
  • The team wondered, could this regeneration be directed to heal damaged brain tissue? (sciencelearn.org.nz)
  • The brain scans were compared with another 39 brain scans, taken in patients without broken-heart syndrome. (livescience.com)
  • While it is not required for diagnosis or treatment of brainstem glioma, judicious use of biopsy/resection is recommended when safe. (medscape.com)
  • 2002 Review Childhood Brain Stem Glioma Treatment (PDQ®): Patient Version [PDQ Cancer Information Summari. (nih.gov)
  • Previous research has shown that abnormal activity in the amygdala in particular - an area of the brain involved with fear - has been linked to an increased risk of heart disease according to the study. (livescience.com)
  • The field of stem cell research was opened wide. (sciencelearn.org.nz)
  • The Brain & Behavior Research Foundation is a 501(c)(3) nonprofit organization, our Tax ID # is 31-1020010. (bbrfoundation.org)
  • The data from this study has led to the formation of a new Hamilton-based start-up brain cancer immunotherapy company called Empirica Therapeutics. (weeksmd.com)
  • We're dependent on brain stem function for survival. (healthline.com)
  • Normal voiding is essentially a spinal reflex modulated by the central nervous system (brain and spinal cord), which coordinates function of the bladder and urethra. (medscape.com)
  • Aim: To analyze the wave characteristics of brainstem evoked potential (BEP), observe normative BEP V wave latency-intensity function curve and changes of corresponding threshold, and provide the reference for the combined application of air-conduction and bone-conduction BEP in clinic. (who.int)
  • To confirm the existence of this brain circuit, Yackle and his team studied the sounds made by baby mice when they were separated from their mothers. (technologynetworks.com)
  • Syringobulbia , which is rare, usually occurs as a slitlike gap within the lower brain stem and may disrupt or compress the lower cranial nerve nuclei or ascending sensory or descending motor pathways. (msdmanuals.com)
  • While some of her brain scans have been encouraging, she has felt serious side effects and it's unclear in the longer term how her MS will do. (ipscell.com)
  • Autophagy is a multifaceted cellular process that not only maintains the homeostatic and adaptive responses of the brain but is also dynamically involved in the regulation of neural cell generation, maturation, and survival . (bvsalud.org)
  • The central nervous system is composed of the brain, brain stem, and the spinal cord. (medscape.com)
  • Crossed deficits (facial signs and symptoms contralateral to arm/leg signs and symptoms) are also characteristic of brainstem gliomas. (medscape.com)
  • The study details are published in Cell Stem Cell. (weeksmd.com)
  • Beijing Tiantan Puhua Hospital in China provides the world's most advanced stem cell procedures and treatments in Asia's top neurosurgical hospital, bringing new hope and a better quality of life to people all over the globe. (mediescapes.com)
  • Sitting just above the spinal cord, the brain stem controls your breathing, heartbeat, and blood pressure. (healthline.com)
  • Contribution of brainstem GABAergic circuitry to descending antinociceptive controls: II. (nih.gov)
  • It's been widely understood that many animals, including humans, have innate control of breathing-you don't have to use your brain to do it. (technologynetworks.com)
  • Approximately 60% of the time they are centered within the pons, but can arise from the midbrain or medulla, and can infiltrate beyond the brainstem. (medscape.com)