AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and Occupations
Brain NeoplasmsInfratentorial NeoplasmsNeoplasms, NeuroepithelialIothalamic AcidGliomaMagnetic Resonance ImagingBrain ChemistryBrain InjuriesBrain MappingPancreatic NeoplasmsNeoplasmsBrainNeoplasms, Cystic, Mucinous, and SerousBrain EdemaBrain StemBrain IschemiaSkin NeoplasmsNeoplasms, Multiple PrimaryBrain AbscessImmunohistochemistryKidney NeoplasmsNeoplasms, Second PrimaryThyroid NeoplasmsAdenocarcinoma, MucinousMyeloproliferative DisordersLung NeoplasmsNeuronsDNA, NeoplasmHypoxia, BrainBlood-Brain BarrierParotid NeoplasmsCerebral CortexCystadenomaNeoplasms, Connective and Soft TissueLiver NeoplasmsNeoplasms, Plasma CellAppendiceal NeoplasmsCystadenoma, MucinousOvarian NeoplasmsNeoplasms, ExperimentalEndocrine Gland NeoplasmsGastrointestinal Neoplasms
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Infratentorial Neoplasms
Intracranial tumors originating in the region of the brain inferior to the tentorium cerebelli, which contains the cerebellum, fourth ventricle, cerebellopontine angle, brain stem, and related structures. Primary tumors of this region are more frequent in children, and may present with ATAXIA; CRANIAL NERVE DISEASES; vomiting; HEADACHE; HYDROCEPHALUS; or other signs of neurologic dysfunction. Relatively frequent histologic subtypes include TERATOMA; MEDULLOBLASTOMA; GLIOBLASTOMA; ASTROCYTOMA; EPENDYMOMA; CRANIOPHARYNGIOMA; and choroid plexus papilloma (PAPILLOMA, CHOROID PLEXUS).
Neoplasms, Neuroepithelial
Neoplasms composed of neuroepithelial cells, which have the capacity to differentiate into NEURONS, oligodendrocytes, and ASTROCYTES. The majority of craniospinal tumors are of neuroepithelial origin. (From Dev Biol 1998 Aug 1;200(1):1-5)
Iothalamic Acid
A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts.
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Magnetic Resonance Imaging
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Brain Chemistry
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Brain Injuries
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Brain Mapping
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Neoplasms, Cystic, Mucinous, and Serous
Neoplasms containing cyst-like formations or producing mucin or serum.
Brain Edema
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Brain Stem
The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
Brain Ischemia
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Skin Neoplasms
Tumors or cancer of the SKIN.
Neoplasms, Multiple Primary
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Brain Abscess
A circumscribed collection of purulent exudate in the brain, due to bacterial and other infections. The majority are caused by spread of infected material from a focus of suppuration elsewhere in the body, notably the PARANASAL SINUSES, middle ear (see EAR, MIDDLE); HEART (see also ENDOCARDITIS, BACTERIAL), and LUNG. Penetrating CRANIOCEREBRAL TRAUMA and NEUROSURGICAL PROCEDURES may also be associated with this condition. Clinical manifestations include HEADACHE; SEIZURES; focal neurologic deficits; and alterations of consciousness. (Adams et al., Principles of Neurology, 6th ed, pp712-6)
Immunohistochemistry
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Kidney Neoplasms
Tumors or cancers of the KIDNEY.
Neoplasms, Second Primary
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Thyroid Neoplasms
Tumors or cancer of the THYROID GLAND.
Adenocarcinoma, Mucinous
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Myeloproliferative Disorders
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
Lung Neoplasms
Tumors or cancer of the LUNG.
Neurons
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
DNA, Neoplasm
DNA present in neoplastic tissue.
Hypoxia, Brain
A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.
Blood-Brain Barrier
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
Parotid Neoplasms
Tumors or cancer of the PAROTID GLAND.
Cerebral Cortex
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
Cystadenoma
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)
Neoplasms, Connective and Soft Tissue
Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.
Liver Neoplasms
Tumors or cancer of the LIVER.
Neoplasms, Plasma Cell
Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.
Appendiceal Neoplasms
Tumors or cancer of the APPENDIX.
Cystadenoma, Mucinous
A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Neoplasms, Experimental
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Endocrine Gland Neoplasms
Tumors or cancer of the ENDOCRINE GLANDS.
Gastrointestinal Neoplasms
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.

Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells. (1/10928)

We have investigated the effects of the truncated trkB receptor isoform T1 (trkB.T1) by transient transfection into mouse N2a neuroblastoma cells. We observed that expression of trkB.T1 leads to a striking change in cell morphology characterized by outgrowth of filopodia and processes. A similar morphological response was also observed in SH-SY5Y human neuroblastoma cells and NIH3T3 fibroblasts transfected with trkB.T1. N2a cells lack endogenous expression of trkB isoforms, but express barely detectable amounts of its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). The morphological change was ligand-independent, since addition of exogenous BDNF or NT-4 or blockade of endogenous trkB ligands did not influence this response. Filopodia and process outgrowth was significantly suppressed when full-length trkB.TK+ was cotransfected together with trkB.T1 and this inhibitory effect was blocked by tyrosine kinase inhibitor K252a. Transfection of trkB.T1 deletion mutants showed that the morphological response is dependent on the extracellular, but not the intracellular domain of the receptor. Our results suggest a novel ligand-independent role for truncated trkB in the regulation of cellular morphology.  (+info)

Transduction of glioma cells using a high-titer retroviral vector system and their subsequent migration in brain tumors. (2/10928)

The intracranial migration of transduced glioma cells was investigated in order to improve the treatment of malignant glioma by gene therapy using retroviral vectors. In this study, about half the volume of the tumor mass could be transduced in 14 days after only a single implantation of 3 x 10(5) retrovirus-producing cells into a tumor mass with a diameter of 5 mm. Moreover, we were able to follow the migration of glioma cells transduced by the lacZ-harboring retroviruses originating from the high-titer retrovirus-producing cells. Besides the importance of using a high-titer retroviral vector system, our results also indicate that the implantation site of the virus-producing cells and the interval between the implantation of the virus-producing cells and the subsequent administration of ganciclovir are important factors for the efficient killing of glioma cells.  (+info)

An improved method for the structural profiling of keratan sulfates: analysis of keratan sulfates from brain and ovarian tumors. (3/10928)

A previously developed method for the structural fingerprinting of keratan sulfates (Brown et al., Glycobiology, 5, 311-317, 1995) has been adapted for use with oligosaccharides fluorescently labeled with 2-aminobenzoic acid following keratanase II digestion. The oligosaccharides are separated by high-pH anion-exchange chromatography on a Dionex AS4A-SC column. This methodology permits quantitative analysis of labeled oligosaccharides which can be detected at the sub-nanogram ( approximately 100 fmol) level. Satisfactory calibration of this method can be achieved using commercial keratan sulfate standards. Keratan sulfates from porcine brain phosphocan and human ovarian tumors have been examined using this methodology, and their structural features are discussed.  (+info)

Synthesis and evaluation of [18F]1-amino-3-fluorocyclobutane-1-carboxylic acid to image brain tumors. (4/10928)

We have developed a new tumor-avid amino acid, 1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC), labeled with 18F for nuclear medicine imaging. METHODS: [18F]FACBC was prepared with high specific activity (no carrier added [NCA]) and was evaluated for its potential in tumor localization. A comparative study was performed for [18F]FACBC and [18F]2-fluorodeoxyglucose (FDG) in which the uptake of each agent in 9L gliosarcoma (implanted intracerebrally in Fisher 344 rats) was measured. In addition, the first human PET study of [18F]FACBC was performed on a patient with residual glioblastoma multiforme. Quantitative brain images of the patient were obtained by using a Siemens 921 47-slice PET imaging system. RESULTS: In the rat brain, the initial level of radioactivity accumulation after injection of [18F]FACBC was low (0.11 percentage injected dose per gram [%ID/g]) at 5 min and increased slightly to 0.26 %ID/g at 60 min. The tumor uptake exhibited a maximum at 60 min (1.72 %ID/g), resulting in a tumor-to-brain ratio increase of 5.58 at 5 min to 6.61 at 60 min. In the patient, the uptake of [18F]FACBC in the tumor exhibited a maximum concentration of 146 nCi/mL at 35 min after injection. The uptake of radioactivity in the normal brain tissue was low, 21 nCi/mL at 15 min after injection, and gradually increased to 29 nCi/mL at 60 min after injection. The ratio of tumor to normal tissue was 6 at 20 min after injection. The [18F]FACBC PET scan showed intense uptake in the left frontal region of the brain. CONCLUSION: The amino acid FACBC can be radiofluorinated for clinical use. [18F]FACBC is a potential PET tracer for tumor imaging.  (+info)

Spontaneous pinealoma in a male Crj:CD (SD) IGS rat. (5/10928)

A pinealoma (benign) was found in a 61-week-old male Crj:CD (SD) IGS rat. The neoplasm was located between the cerebral hemispheres and the cerebellum. Histologically, the tumor cells consisted of two cell types: large, pale-staining cells and small dark-staining cells. A fibrovascular stroma divided the tumor cells into incomplete lobules or nest structures. Relatively numerous mitoses were noted in the tumor cells. Ultrastructurally, the tumor cells contained dense-cored vesicles, approximately 120 nm in diameter.  (+info)

Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma. (6/10928)

Inhibition of angiogenesis has been shown to reduce tumor growth, metastasis, and tumor microvascular density in experimental models. To these effects we would now like to add induction of differentiation, based on biological analysis of xenografted human neuroblastoma (SH-SY5Y, WAG rnu/rnu) treated with the angiogenesis inhibitor TNP-470. Treatment with TNP-470 (10 mg/kg s.c., n = 15) reduced the tumor growth by 66% and stereological vascular parameters (Lv, Vv, Sv) by 36-45%. The tumor cell apoptotic fraction increased more than threefold, resulting in a decrease in viable tumor cells by 33%. In contrast, the mean vascular diameter (29 microm) and the mean tumor cell proliferative index (49%) were unaffected. TNP-470-treated tumors exhibited striking chromaffin differentiation of neuroblastoma cells, observed as increased expression of insulin-like growth factor II gene (+88%), tyrosine hydroxylase (+96%), chromogranin A, and cellular processes. Statistical analysis revealed an inverse correlation between differentiation and angiogenesis. It is suggested that by inhibiting angiogenesis, TNP-470 induces metabolic stress, resulting in chromaffin differentiation and apoptosis in neuroblastoma. Such agonal differentiation may be the link between angiostatic therapy and tumor cell apoptosis.  (+info)

Expression and tissue localization of membrane-type 1, 2, and 3 matrix metalloproteinases in human astrocytic tumors. (7/10928)

Three different membrane-type matrix metalloproteinases (MT1-, MT2-, and MT3-MMPs) are known to activate in vitro the zymogen of MMP-2 (pro-MMP-2, progelatinase A), which is one of the key MMPs in invasion and metastasis of various cancers. In the present study, we have examined production and activation of pro-MMP-2, expression of MT1-, MT2-, and MT3-MMPs and their correlation with pro-MMP-2 activation, and localization of MMP-2, MT1-MMP, and MT2-MMP in human astrocytic tumors. The sandwich enzyme immunoassay demonstrates that the production levels of pro-MMP-2 in the anaplastic astrocytomas and glioblastomas are significantly higher than that in the low-grade astrocytomas (P<0.05 and P<0.01, respectively), metastatic brain tumors (P<0.05), or normal brains (P<0.01). Gelatin zymography indicates that the pro-MMP-2 activation ratio is significantly higher in the glioblastomas than in other astrocytic tumors (P<0.01), metastatic brain tumors (P<0.01), and normal brains (P<0.01). The quantitative reverse transcription polymerase chain reaction analyses demonstrate that MT1-MMP and MT2-MMP are expressed predominantly in glioblastoma tissues (17/17 and 12/17 cases, respectively), and their expression levels increase significantly as tumor grade increases. MT3-MMP is detectable in both astrocytic tumor and normal brain tissues, but the mean expression level is approximately 50-fold lower compared with that of MT1-MMP and MT2-MMP in the glioblastomas. The activation ratio of pro-MMP-2 correlates directly with the expression levels of MT1-MMP and MT2-MMP but not MT3-MMP. In situ hybridization indicates that neoplastic astrocytes express MT1-MMP and MT2-MMP in the glioblastoma tissues (5/5 cases and 5/5 cases, respectively). Immunohistochemically, MT1-MMP and MT2-MMP are localized to the neoplastic astrocytes in glioblastoma samples (17/17 cases and 12/17 cases, respectively), which are also positive for MMP-2. In situ zymography shows gelatinolytic activity in the glioblastoma tissues but not in the normal brain tissues. These results suggest that both MT1-MMP and MT2-MMP play a key role in the activation of pro-MMP-2 in the human malignant astrocytic tumors and that the gelatinolytic activity is involved in the astrocytic tumor invasion.  (+info)

Early induction of angiogenetic signals in gliomas of GFAP-v-src transgenic mice. (8/10928)

Angiogenesis is a prerequisite for solid tumor growth. Glioblastoma multiforme, the most common malignant brain tumor, is characterized by extensive vascular proliferation. We previously showed that transgenic mice expressing a GFAP-v-src fusion gene in astrocytes develop low-grade astrocytomas that progressively evolve into hypervascularized glioblastomas. Here, we examined whether tumor progression triggers angiogenetic signals. We found abundant transcription of vascular endothelial growth factor (VEGF) in neoplastic astrocytes at surprisingly early stages of tumorigenesis. VEGF and v-src expression patterns were not identical, suggesting that VEGF activation was not only dependent on v-src. Late-stage gliomas showed perinecrotic VEGF up-regulation similarly to human glioblastoma. Expression patterns of the endothelial angiogenic receptors flt-1, flk-1, tie-1, and tie-2 were similar to those described in human gliomas, but flt-1 was expressed also in neoplastic astrocytes, suggesting an autocrine role in tumor growth. In crossbreeding experiments, hemizygous ablation of the tumor suppressor genes Rb and p53 had no significant effect on the expression of VEGF, flt-1, flk-1, tie-1, and tie-2. Therefore, expression of angiogenic signals is an early event during progression of GFAP-v-src tumors and precedes hypervascularization. Given the close similarities in the progression pattern between GFAP-v-src and human gliomas, the present results suggest that these mice may provide a useful tool for antiangiogenic therapy research.  (+info)

Longitudinal MRI Evaluation of Intracranial Development and Vascular Characteristics of Breast Cancer Brain Metastases in a...
TY - JOUR. T1 - Longitudinal MRI Evaluation of Intracranial Development and Vascular Characteristics of Breast Cancer Brain Metastases in a Mouse Model. AU - Zhou, Heling. AU - Chen, Min. AU - Zhao, Dawen. PY - 2013/4/29. Y1 - 2013/4/29. N2 - Longitudinal MRI was applied to monitor intracranial initiation and development of brain metastases and assess tumor vascular volume and permeability in a mouse model of breast cancer brain metastases. Using a 9.4T system, high resolution anatomic MRI and dynamic susceptibility contrast (DSC) perfusion MRI were acquired at different time points after an intracardiac injection of brain-tropic breast cancer MDA-MB231BR-EGFP cells. Three weeks post injection, multifocal brain metastases were first observed with hyperintensity on T2-weighted images, but isointensity on T1-weighted post contrast images, indicating that blood-tumor-barrier (BTB) at early stage of brain metastases was impermeable. Follow-up MRI revealed intracranial tumor growth and increased ...
https://utsouthwestern.pure.elsevier.com/en/publications/longitudinal-mri-evaluation-of-intracranial-development-and-vascu
Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors: A pediatric brain tumor consortium study<...
TY - JOUR. T1 - Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors. T2 - A pediatric brain tumor consortium study. AU - Gururangan, Sridharan. AU - Turner, Christopher D.. AU - Stewart, Clinton F.. AU - OShaughnessy, Melinda. AU - Kocak, Mehmet. AU - Poussaint, Tina Young. AU - Phillips, Peter C.. AU - Goldman, Stewart. AU - Packer, Roger. AU - Pollack, Ian F.. AU - Blaney, Susan M.. AU - Karsten, Verena. AU - Gerson, Stanton L.. AU - Boyett, James M.. AU - Friedman, Henry S.. AU - Kun, Larry E.. PY - 2008/2/15. Y1 - 2008/2/15. N2 - Purpose: VNP40101M (Cloretazine), a novel DNA alkylating agent, was evaluated in a phase I study in children with recurrent brain tumors. Experimental Design: VNP40101M was given i.v. daily for 5 consecutive days every 6 weeks for up to eight cycles. Dose escalation was done independently in patients stratified based on intensity of prior therapy (moderately pretreated, stratum I; heavily pretreated, stratum II). Correlative studies ...
https://utsouthwestern.pure.elsevier.com/en/publications/phase-i-trial-of-vnp40101m-cloretazine-in-children-with-recurrent
Comprehensive molecular biomarker identification in breast cancer brain metastases | Journal of Translational Medicine | Full...Comprehensive molecular biomarker identification in breast cancer brain metastases | Journal of Translational Medicine | Full...
Breast cancer brain metastases (BCBM) develop in about 20-30% of breast cancer (BC) patients. BCBM are associated with dismal prognosis not at least due to lack of valuable molecular therapeutic targets. The aim of the study was to identify new molecular biomarkers and targets in BCBM by using complementary state-of-the-art techniques. We compared array expression profiles of three BCBM with 16 non-brain metastatic BC and 16 primary brain tumors (prBT) using a false discovery rate (FDR) p | 0.05 and fold change (FC) | 2. Biofunctional analysis was conducted on the differentially expressed probe sets. High-density arrays were employed to detect copy number variations (CNVs) and whole exome sequencing (WES) with paired-end reads of 150 bp was utilized to detect gene mutations in the three BCBM. The top 370 probe sets that were differentially expressed between BCBM and both BC and prBT were in the majority comparably overexpressed in BCBM and included, e.g. the coding genes BCL3, BNIP3, BNIP3P1, BRIP1,
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1370-x/figures/6
Clinicopathological significance of N-cadherin and VEGF in advanced gastric cancer brain metastasis and the effects of...Clinicopathological significance of N-cadherin and VEGF in advanced gastric cancer brain metastasis and the effects of...
TY - JOUR. T1 - Clinicopathological significance of N-cadherin and VEGF in advanced gastric cancer brain metastasis and the effects of metformin in preclinical models. AU - Jun, Kyong Hwa. AU - Lee, Jung Eun. AU - Kim, Se Hoon. AU - Jung, Ji Han. AU - Choi, Hyun Joo. AU - Kim, Young Il. AU - Chin, Hyung Min. AU - Yang, Seung Ho. PY - 2015/10/1. Y1 - 2015/10/1. N2 - Gastric cancer is the second most common cause of cancer-related death worldwide. Although brain metastasis is a rare complication of gastric cancer, no standard therapy for gastric cancer brain metastasis has been established. We attempted to identify biological markers that predict brain metastasis, and investigated how to modulate such markers. A case-control study of patients newly diagnosed with gastric cancer who had developed brain metastasis during follow-up, was conducted. These patients were compared with patients who had advanced gastric cancer but no evidence of brain metastasis. Immunohistochemistry was used to analyze ...
https://yonsei.pure.elsevier.com/en/publications/clinicopathological-significance-of-n-cadherin-and-vegf-in-advanc
Cases reported • Brain Neoplasms; Brain Cancer; Brain Tumors; Cancer of Brain; Malignant Primary Brain Tumors; Neoplasms,...Cases reported • Brain Neoplasms; Brain Cancer; Brain Tumors; Cancer of Brain; Malignant Primary Brain Tumors; Neoplasms,...
Cases reported • Brain Neoplasms; Brain Cancer; Brain Tumors; Cancer of Brain; Malignant Primary Brain Tumors; Neoplasms, Intracranial. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
https://lookfordiagnosis.com/cases.php?term=Brain+Neoplasms&filter=macrophage%7Cbone&values=0.011892%7C0.003593&lang=1
Cases reported • Brain Neoplasms; Brain Cancer; Brain Tumors; Cancer of Brain; Malignant Primary Brain Tumors; Neoplasms,...Cases reported • Brain Neoplasms; Brain Cancer; Brain Tumors; Cancer of Brain; Malignant Primary Brain Tumors; Neoplasms,...
Cases reported • Brain Neoplasms; Brain Cancer; Brain Tumors; Cancer of Brain; Malignant Primary Brain Tumors; Neoplasms, Intracranial. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
https://lookfordiagnosis.com/cases.php?term=Brain+Neoplasms&filter=schwann+cell%7Cschwann&values=0.019374%7C0.011095&lang=1
Imaging Needed to Monitor Melanoma Brain Metastases During PD-1 Therapy | Journal Of Clinical PathwaysImaging Needed to Monitor Melanoma Brain Metastases During PD-1 Therapy | Journal Of Clinical Pathways
Central nervous system imaging is needed during programmed death 1 (PD-1) inhibitor therapy to monitor incidence, patterns of progression, and outcomes of melanoma brain metastases, according to research presented at the 2017 ASCO Annual Meeting (June 2-6, 2017; Chicago, IL).. -----. Related Content. Ipilimumab Combination Significantly Improves Melanoma Outcomes. Skip whole-brain radiation in patients with limited brain metastases. -----. Metastases in the brain is a common occurrence for patients with metastatic melanoma. Currently available therapies are often unable to treat metastatic melanoma tumors in the brain. Limited data exists concerning the incidence, patterns of progression, and outcomes of patients with melanoma brain metastasis treated with PD-1 inhibitors, particularly in conjunction with central nervous system-focused therapy.. Gustavo Schvartsman, MD, MD Anderson Cancer Center (Houston, TX), and colleagues retrospectively reviewed the survival outcomes of patients with ...
https://www.journalofclinicalpathways.com/article/imaging-needed-monitor-melanoma-brain-metastases-during-pd-1-therapy
IB Neuro Earns Recognition as National Standard for Use in High-grade Brain Tumors | Imaging Technology NewsIB Neuro Earns Recognition as National Standard for Use in High-grade Brain Tumors | Imaging Technology News
June 19, 2020 - Imaging Biometrics, LLC (IB), a subsidiary of IQ-AI Limited and a recognized leader in quantitative imaging analysis for brain tumor diagnosis and treatment, today announced that the MRI DSC perfusion technology, first made commercially available in IB Neuro, earned recognition as the national standard for use in high-grade brain tumors. This recognition was the outcome of the DSC-MRI Standardization Subcommittee of the Jumpstarting Brain Tumor Drug Development Coalition. The Committees findings, published in Neuro Oncology (Consensus Recommendations for a DSC MRI Protocol), provide evidence-based best practices for routine clinical use from both an MR acquisition and post-processing perspective. DSC, which stands for dynamic susceptibility contrast, is the most common perfusion MRI technology used for the evaluation of brain tumors. This national consensus is long overdue. Despite its widespread use, MRI-DSC imaging has been plagued by inconsistent and suboptimal ways of ...
https://www.itnonline.com/content/ib-neuro-earns%C2%A0recognition-national-standard-use-high-grade-brain-tumors
Metastatic Brain Tumors - Get Through It Together
A metastatic, or secondary, brain tumor is one that begins as cancer in another part of the body. Some of the cancer cells may be carried to the brain by the blood or lymphatic fluid, or may spread from adjacent tissue. The site where the cancerous cells originated is referred to as the primary cancer. Metastatic brain tumors are often referred to as lesions or brain metastases. Metastatic brain tumors are the most common brain tumors. There has been an increase in metastatic lesions as people are surviving primary cancers for longer periods of time ...
http://getthroughittogether.weebly.com/metastatic-brain-tumors.html
Diagnosis of recurrent brain tumor: Value of <sup>201</sup>TI SPECT vs <sup>18</sup>F-...
TY - JOUR. T1 - Diagnosis of recurrent brain tumor. T2 - Value of 201TI SPECT vs 18F- fluorodeoxyglucose PET. AU - Kahn, D.. AU - Follett, K. A.. AU - Bushnell, D. L.. AU - Nathan, M. A.. AU - Piper, J. G.. AU - Madsen, M.. AU - Kirchner, P. T.. PY - 1994. Y1 - 1994. N2 - OBJECTIVE. This prospective study was designed to compare the sensitivity and specificity of a relatively simple examination, 201TI chloride single- photon emission CT (SPECT), with a more complex examination, 18F- fluorodeoxyglucose (FDG) positron emission tomography (PET), in patients thought to have recurrent brain tumor. Because both agents have been shown to be markers of viable tumor, we hypothesized that their sensitivity and specificity should be the same. SUBJECTS AND METHODS. Nineteen patients with evidence of recurrent tumor on CT or MR images were studied with both 201TI SPECT and FDG PET imaging. Two patients were examined twice, so a total of 21 studies were evaluated. The 201TI SPECT and FDG PET examinations were ...
https://experts.nebraska.edu/en/publications/diagnosis-of-recurrent-brain-tumor-value-of-sup201supti-spect-vs-
Visionary approach for the treatment of brain tumors<...
TY - JOUR. T1 - Visionary approach for the treatment of brain tumors. AU - Yoshimoto, Koji. AU - Kada, Akiko. AU - Hatae, Ryusuke. AU - Murata, Hideki. AU - Akagi, Yojiro. AU - Nishimura, Kunihiro. AU - Mizoguchi, Masahiro. AU - Iihara, Koji. PY - 2015/10/25. Y1 - 2015/10/25. N2 - To investigate patient background and current trends in the treatment of brain tumor patients, we analyzed a patient dataset using the Diagnosis Procedure Combination(DPC) database. The DPC data of all inpatients treated between April 2013 and March 2014 in the 327 core and branch hospitals enrolled in the Japan Neurosurgical Society training program were collected. Using ICD-10 code, we could extract 6,142 primary malignant brain tumor patients, 2,538 secondary malignant brain tumor patients, 2,043 pituitary tumor patients, 3,854 meningioma patients, and 5,666 other benign brain tumor patients from amongst a total of 501,609 patients. In this study, we focused on the primary and secondary malignant brain tumor ...
https://kyushu-u.pure.elsevier.com/ja/publications/visionary-approach-for-the-treatment-of-brain-tumors
T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases...T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases...
Background:. Sometimes breast cancer spreads (metastasizes) to the brain. Researchers want to study new treatments for brain metastases. The drug Temozolomide is approved to treat brain tumors. Researchers want to see if combining it with the drug T-DMI prevents the formation of new metastases in the brain.. Objective:. To study if Temozolomide with T-DM1 lowers the chance of having new metastases in the brain.. Eligibility:. Adults at least 18 years old with a HER2-positive breast cancer that has spread to the brain and was recently treated with stereotactic radiation or surgery.. Design:. Participants will be screened with. ...
https://clinicaltrials.gov/ct2/show/study/NCT03190967?view=record
Stereotactic Radiotherapy of Resection Cavity For Single Brain Metastasis Versus Whole-Brain Radiotherapy After Resection -...Stereotactic Radiotherapy of Resection Cavity For Single Brain Metastasis Versus Whole-Brain Radiotherapy After Resection -...
Patients with surgically removed single brain metastasis are randomly allocated to control or experimental arm. Before treatment the MRC Neurological Status Scale is used for assessing neurological status, the EORTC QLQ-C30 and QLQ-BN20 for quality of life and Mini-Mental State Examination to assess cognitive functioning. The control group receive 30Gy in 10 fractions of 3Gy over 12 days to the whole brain. The patients in the experimental arm are treated with stereotactic radiotherapy to the resection cavity. The dose to the tumor bed is 15-18Gy in one fraction or 25Gy in 5 fractions. The study hypothesis is that the difference in the 5-months failure free survival rate isnt higher than 25% in experimental arm compared to control arm ...
https://clinicaltrials.gov/ct2/show/NCT01535209?recr=Open&intr=radiotherapy&rank=9
Pediatric brain tumors - Diseases & ConditionsPediatric brain tumors - Diseases & Conditions
Pediatric brain tumors are masses or growths of abnormal cells that occur in the brain or the tissue and structures that are near it. Many different types of pediatric brain tumors exist. Some pediatric brain tumors are noncancerous (benign), and some pediatric brain tumors are cancerous (malignant).
http://pharmacypedia.org/diseases-and-conditions/pediatric-brain-tumors/
US$ 1659.4 Million by 2023 worth of Revenue Growth Expected From Global Pediatric Brain Tumor Market - ABNewswire - Press...US$ 1659.4 Million by 2023 worth of Revenue Growth Expected From Global Pediatric Brain Tumor Market - ABNewswire - Press...
Pediatric brain cancer is one of the most common forms of disease diagnosed in children. Market Research Future, a firm which specializes in market reports related to the healthcare sector among others, published in its recent report on Pediatric Brain Tumor Market Research Report - Global Forecast till 2023, that the global pediatric brain tumor market is growing at the CAGR of 4.1% during the forecast period and expected to reach US$ 1659.4 million by 2023. Increasing incidences of pediatric brain tumor are being identified around the world which has contributed gradually to the growth of the market.. The main causative factor for pediatric brain tumor market is genetics. Most of the tumors are diagnosed after child birth till 12 years of age, which is usually detected after appearance of certain symptoms. Due to the appearance of additional types of mutations in terms of pediatric brain tumor, the scope of the market has widened significantly. Most of the tumors currently known in this ...
http://www.abnewswire.com/pressreleases/us-16594-million-by-2023-worth-of-revenue-growth-expected-from-global-pediatric-brain-tumor-market_170778.html
Advanced age negatively impacts survival in an experimental brain tumor model<...
TY - JOUR. T1 - Advanced age negatively impacts survival in an experimental brain tumor model. AU - Ladomersky, Erik. AU - Zhai, Lijie. AU - Gritsina, Galina. AU - Genet, Matthew. AU - Lauing, Kristen L.. AU - Wu, Meijing. AU - James, C. David. AU - Wainwright, Derek A.. N1 - Funding Information: C.D. James is supported by PHS grant numbers P50CA097257 , R01CA159467 , awarded by the NIH/NCI , as well as R01NS080619 , awarded by the NIH/NINDS and D.A. Wainwright is supported by PHS grant numbers R00NS082381 and R01NS097851 , awarded by the NIH/NINDS, U.S. Department of Health and Human Services; a Robert H. Lurie Comprehensive Cancer Center - Zell Scholar Program of the Zell Family Foundation Gift; and the Northwestern Brain Tumor Institute. PY - 2016/9/6. Y1 - 2016/9/6. N2 - Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with an average age of 64 years at the time of diagnosis. To study GBM, a number of mouse brain tumor models have been utilized. In these animal ...
https://www.scholars.northwestern.edu/en/publications/advanced-age-negatively-impacts-survival-in-an-experimental-brain
Metastatic Brain Tumors | MDedge Hematology and OncologyMetastatic Brain Tumors | MDedge Hematology and Oncology
Series Editor: Arthur T. Skarin, MD, FACP, FCCP Systemic cancer can affect the central nervous system in several different ways, including direct tumor metastasis and indirect remote effects. Intracranial metastasis can involve the skull, dura, and leptomeninges (arachnoid and pia mater), as well as the brain parenchyma. Of these, parenchymal brain metastases are the most common and have been found in as many as 24% of cancer patients in autopsy studies. It has been reported that metastatic brain tumors outnumber primary brain tumors 10 to 1. To read the full article in PDF: Click here ...
https://www.mdedge.com/hematology-oncology/article/146137/cns/brain-cancer/metastatic-brain-tumors?channel=41019
who knows about brain radiation? | Cancer Survivors Networkwho knows about brain radiation? | Cancer Survivors Network
Side Effects of Whole Brain Radiation. The initial approach to using radiation postoperatively to treat brain metastases, used to be whole brain radiation, but this was abandoned because of the substantial neurological deficits that resulted, sometimes appearing a considerable time after treatment. Whole brain radiation was routinely administered to patients after craniotomy for excision of a cerebral metastasis in an attempt to destroy any residual cancer cells at the surgical site. However, the deleterious effects of whole brain radiation, such as dementia and other irreversible neurotoxicities, became evident. This raised the question as to whether elective postoperative whole brain radiation should be administered to patients after excision of a solitary brain metastasis. Current clinical practice, at most leading cancer centers, use a more focused radiation field that includes only 2-3cm beyond the periphery of the tumor site. This may involve therapy once a day for about six weeks and ...
https://csn.cancer.org/node/143438
Plus itPlus it
2814 An estimated 30% of breast cancer patients have metastases to the brain and no effective treatment is yet available. Breast cancer brain metastases flourishes under the brains highly vascularized microenvironment, which provides nutrients and oxygen to the tumor. The purpose of this study was to analyze the functional properties of endothelial cells derived from metastatic breast cancer to the brain (BBEC). BBEC were isolated from brain tissue specimens of a patient with advanced breast cancer brain metastases. Primary cultures of human BBEC were purified using flow cytometry and characterized as endothelial cells based on positive immunostaining for Factor VIII, CD31, and CD105. BBEC are morphologically larger and more flattened than normal brain endothelial cells (BEC). A functional analysis of BBEC demonstrate that these cells proliferate more slowly than the BEC, and exhibit a significantly higher expression of the proangiogenic growth factors: vascular endothelial growth factor ...
http://cancerres.aacrjournals.org/content/66/8_Supplement/661.1
Rehabilitation of motor dysfunction in primary brain tumor patients<...
TY - JOUR. T1 - Rehabilitation of motor dysfunction in primary brain tumor patients. AU - Kushner, David S.. AU - Amidei, Christina. N1 - Publisher Copyright: © The Author(s) 2015.. PY - 2015/2/26. Y1 - 2015/2/26. N2 - In 2010 it was estimated that .688 000 Americans were living with a primary brain tumor (PBT) corresponding to a U.S. prevalence rate of approximately 221.8 per 100 000 people. Five-year survival is 96.1% in nonmalignant PBTs, 34% in malignant PBTs for all ages, and 71% in children [1985-2005]. Case fatality rates have decreased in the U.S. since the 1970s for nonmalignant PBTs and for medulloblastoma, oligodendroglioma, and astrocytoma. Statistics of increasing survival highlight the importance of rehabilitation interventions to improve function and quality of life in survivors. PBT motor dysfunction is multifactorial, occurring as a result of direct effects of tumor and/or swelling or as a result of treatments; etiologies include encephalopathy, myopathy, neuropathy, ...
https://miami.pure.elsevier.com/en/publications/rehabilitation-of-motor-dysfunction-in-primary-brain-tumor-patien-2
Perilesional edema in brain metastases: potential causes and implications for treatment with immune therapy | Journal for...Perilesional edema in brain metastases: potential causes and implications for treatment with immune therapy | Journal for...
Little is known about tumor-associated vasogenic edema in brain metastasis, yet it causes significant morbidity and mortality. Our purpose was to characterize edema in patients treated with anti-PD-1 and to study potential causes of vessel leakage in humans and in pre-clinical models. We analyzed tumor and edema volume in 18 non-small cell lung (NSCLC) and 18 melanoma patients with untreated brain metastases treated with pembrolizumab on a phase II clinical trial. Melanoma brain metastases were stained with anti-CD34 to assess vessel density and its association with edema. We employed an in vitro model of the blood-brain barrier using short-term cultures from melanoma brain and extracranial metastases to determine tight junction resistance as a measure of vessel leakiness. Edema volumes are similar in NSCLC and melanoma brain metastases. While larger tumors tended to have more edema, the correlation was weak (R2 = 0.30). Patients responding to pembrolizumab had concurrent shrinkage of edema volume and
https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0684-z/figures/2
GlaxoSmithKline initiates trial of Tykerb (lapatinib) in patients with ErbB2-overexpressing breast cancer brain metastasis...GlaxoSmithKline initiates trial of Tykerb (lapatinib) in patients with ErbB2-overexpressing breast cancer brain metastasis...
SAN ANTONIO, December 9, 2005 GlaxoSmithKline (GSK) has announced the initiation of a global multicenter Phase II trial (known as EGF105084) to evaluate Tykerb (lapatinib) for the treatment of ErbB2-...
https://www.webwire.com/ViewPressRel.asp?aId=6704
Purpose Glioblastoma (GBM) may be the most commonly diagnosed primary human brain tumor in adults - Serine Protease Inhibitors...
Purpose Glioblastoma (GBM) may be the most commonly diagnosed primary human brain tumor in adults. NHEJ reporter assay. Cell apoptosis was dependant on Caspase3/7 activity. Autophagy was examined using CYTO-ID? Autophagy recognition kit. Tumor development was analyzed by U87 xenograft mice model. Outcomes DNA repair performance of nonhomologous JNJ-28312141 end signing up for (NHEJ) pathway is normally significantly elevated in TMZ- and IR-resistant GBM cells. Significantly, APLF, that is among the DNA end digesting elements in NHEJ, is normally upregulated in Rabbit Polyclonal to TIGD3 TMZ- and IR-resistant GBM sufferers and cells. APLF deficiency considerably decreases NHEJ performance and increases cell awareness to TMZ and IR both in vitro and in vivo. Bottom line Our research provides proof for APLF portion being a promising, book focus on in GBM chemo- and radio-therapy. was performed using quantitative RT-PCR (qPCR) with Fast SYBR? Green Professional Combine (ThermoFisher Scientific) and ...
http://anticaeviae.com/?p=24
brain tumor - Latest Health Tips, News and Articles on brain tumor | TheHealthSite.combrain tumor - Latest Health Tips, News and Articles on brain tumor | TheHealthSite.com
brain tumor- Latest news on brain tumor, health news brain tumor, tips on brain tumor, health tips at thehealthsite.com. Get latest updates on brain tumor, health news and articles, health videos, photos.
https://www.thehealthsite.com/topics/brain-tumor/
Stereotactic radiosurgery combined with nivolumab or Ipilimumab for patients with melanoma brain metastases: evaluation of...Stereotactic radiosurgery combined with nivolumab or Ipilimumab for patients with melanoma brain metastases: evaluation of...
Between September 2012 and December 2017, 112 consecutive patients ≥18 years old receiving combined SRS and ipilimumab or nivolumab for one to ten melanoma brain metastases were retrospectively evaluated. In general, patients with lesions up to 2.5 cm in size were treated with single-fraction SRS, while larger lesions located near or in eloquent areas (i.e., motor, somatosensory, speech, visual cortices, basal ganglia, thalamus, and the brainstem) received multi-fraction SRS to minimize potential increased risk of late radiation-induced brain necrosis (RN).. All radiographic, surgical, and pathological information were drawn from a prospectively maintained database of patients with brain tumors treated at Sant Andrea Hospital and UPMC Hillman Cancer Center San Pietro Hospital. Thirty-two patients were excluded due to insufficient clinical information, previous use of anti-PD-1/PD-L1, brain surgery or radiation. Previous adjuvant therapies, including ipilimumab or BRAF/MEK inhibitors, were ...
https://jitc.bmj.com/content/7/1/102?ijkey=2ff738e4b666a2c40a9cd4c8eb21f16224e0c269&keytype2=tf_ipsecsha
Pediatric Brain Tumors - Columbia NeurosurgeryPediatric Brain Tumors - Columbia Neurosurgery
Pediatric brain tumors are abnormal growths that arise in the brain during childhood. Several treatment options are available, including close observation, surgery, radiation therapy and chemotherapy. Although brain tumors are rare overall, they are the most common solid tumor among children. Whats important to remember is that children are not simply miniature adults. Brain tumors in children behave differently than brain tumors in adults. Whats more, children require treatment that is tailored not just to their tumor type, but also to their age and development. At the Pediatric Neurosurgery Center, we are committed to meeting the special needs of young patients and their families. Pediatric brain tumors can be either benign or malignant. Malignant, or cancerous, tumors tend to be fast-growing and aggressive, invading surrounding brain tissue. Benign tumors are not cancerous; they do not spread and they tend to be slow-growing. Even slow-growing benign brain tumors can eventually become ...
http://www.columbianeurosurgery.org/conditions/pediatric-brain-tumors/
Brain Tumor Surgery | Brain Tumor Treatment | Wockhardt Hospitals InternationalBrain Tumor Surgery | Brain Tumor Treatment | Wockhardt Hospitals International
Wockhardt Hospitals provides brain tumor treatment for international patients from around the world whilst ensuring excellent international patient care. Visit us to know more about the brain tumor surgery in India.
https://international.wockhardthospitals.com/specialities/brain-spine-care/brain-tumor-treatment
NewYork-Presbyterian Queens - Brain Tumors
A brain tumor is an abnormal growth of tissue in the brain. The tumor can either originate in the brain itself (primary brain tumor), or come from another part of the body and travel to the brain (metastastic or secondary brain tumor). Brain tumors may be classified as either benign (noncancerous) or malignant (cancerous), depending on their behavior.. A benign tumor does not contain cancer cells and usually, once removed, does not recur. Most benign brain tumors have clear borders, meaning they do not invade surrounding tissue. These tumors can, however, cause symptoms similar to cancerous tumors because of their size and location in the brain.. Malignant brain tumors contain cancer cells. Malignant brain tumors are usually fast growing and invade surrounding tissue. Malignant brain tumors very rarely spread to other areas of the body, but may recur after treatment. Sometimes, brain tumors that are not cancer are called malignant because of their size and location, and the damage they can do to ...
http://www.nyhq.org/diw/Content.asp?PageID=DIW002627
Brain tumor patients with impaired cognitive flexibility do not efficiently update functional connectivity within the fronto...Brain tumor patients with impaired cognitive flexibility do not efficiently update functional connectivity within the fronto...
TY - JOUR. T1 - Brain tumor patients with impaired cognitive flexibility do not efficiently update functional connectivity within the fronto-parietal network. AU - De Baene, Wouter. AU - Jansma, J.M.. AU - Rutten, Geert-Jan. AU - Sitskoorn, Margriet. PY - 2018. Y1 - 2018. N2 - Background The majority of brain tumor patients suffers from cognitive deficits. These deficits can be very disruptive for a persons daily functioning, quality of life and treatment compliance. Examining functional connectivity patterns during the performance of a cognitive task may enhance our understanding of the relationship between functional brain networks and cognitive performance. Despite the similarity in network topology across rest and task states, there are also meaningful differences in functional connectivity that are likely to be linked to cognitive performance. Currently, it is largely unknown how differences between rest and task functional connectivity patterns are related to cognitive functioning in ...
https://research.tilburguniversity.edu/en/publications/brain-tumor-patients-with-impaired-cognitive-flexibility-do-not-e
Regression of orthotopic brain tumors by cytokine-assisted tumor vaccines primed in the brain<...
TY - JOUR. T1 - Regression of orthotopic brain tumors by cytokine-assisted tumor vaccines primed in the brain. AU - Tseng, Sheng Hong. AU - Hsieh, Chia Ling. AU - Lin, Swei Ming. AU - Hwang, Lih Hwa. PY - 1999. Y1 - 1999. N2 - This study investigated the therapeutic effects of a rat glioma cell line, C6, that was engineered to secrete mouse GM-CSF (mGM-CSF) on intracerebral (i.c.) brain tumors. Significant antitumor immunity was induced in rats when the live or irradiated mGM-CSF-secreting tumor vaccine was implanted i.c. The antitumor activity was effective on small tumors and, to a lesser extent, on large tumors or tumors existing in vivo for a longer duration, Immunohistochemical analysis revealed cellular infiltrates (granulocytes, macrophages, and CD4+ and CD8+ T cells) at both the vaccine site and the tumor site, indicating that immune responses were similarly activated when tumor vaccine was inoculated in the brain, as at the subcutis. Additional studies demonstrated that the therapeutic ...
https://tmu.pure.elsevier.com/en/publications/regression-of-orthotopic-brain-tumors-by-cytokine-assisted-tumor-
Nano-sized delivery systems for immunotherapies - Prof. Ronit Sacthi-Fainaro labNano-sized delivery systems for immunotherapies - Prof. Ronit Sacthi-Fainaro lab
Our research is currently focused on the pharmacological aspects of a multidisciplinary project within the frontier of cancer immunotherapy where nanotechnology, immunology, chemical biology, biotechnology and animal modeling will provide the rationale for novel anticancer treatments. This approach is based on the design of precision nanomedicines that will interfere within tumor-host interactions and stimulate the immune system to attack the tumor cells. We are synthesizing PLGA-based nanovaccines targeting the dendritic cells to activate T cells against primary and secondary brain neoplasms such as glioblastoma, melanoma brain metastases and breast cancer brain metastases. Another immunotherapy approach tagging heteroaryl chemotherapeutic drug molecules with a ketone functional group and employing it for Antibody-Drug Conjugates (ADC) applications was recently published. This project is the basis for an ERC Advanced grant awarded to our lab in 2019-2024. Based on this project, we signed a ...
https://satchifainarolab.com/nano-sized-delivery-systems-for-immunotherapies/
Treatment For Deadly Brain Tumors and Infections Discovered by ResearchersTreatment For Deadly Brain Tumors and Infections Discovered by Researchers
Los Angeles - March 22, 2006 - In a study published in the March 15 issue of The Journal of Immunology, researchers at Board of Governors Gene Therapeutics Research Institute at Cedars-Sinai Medical Center have developed a way to overcome immune privilege in the brain to eradicate potentially deadly brain tumors such as glioblastoma multiforme and other types of brain infections.. Brain tumors account for 85 to 90 percent of all primary central nervous system tumors. Of those tumors, almost 40 percent are either the deadly glioblastoma multiforme or anaplastic astrocytomas. Each year about 19,000 people in the United States are diagnosed with primary brain cancers, and close to 70 percent of those diagnosed will not survive more than five years. In addition, approximately 150,000 Americans a year are diagnosed with metastatic brain tumors, cancer that has spread into the brain from another part of the body.. We have developed a novel gene therapy strategy to modify the brain microenvironment ...
https://www.cedars-sinai.edu/About-Us/News/News-Releases-2006/Treatment-For-Deadly-Brain-Tumors-and-Infections-Discovered-by-Researchers.aspx
Get Highly Specialized Brain Tumor Treatment | Blog IBS HospitalGet Highly Specialized Brain Tumor Treatment | Blog IBS Hospital
Brain is the central organ of the nervous system. The main role of the brain is to control various different activities of our body. It receives and processes all the information that it gets from the sense organs. The decisions are then made according to the signals. There are different diseases and disorders of the brain which does not let our brain function in a normal way. Brain Tumor is one of diseases which when diagnosed, should be treated immediately. For best brain tumor treatment in India, visit IBS Hospitals.. Brain tumor is a condition of the brain in which abnormal mass grows in the cell. A tumor is classified into two parts -. ...
https://www.ibshospitals.com/blog/title/get-highly-specialized-brain-tumor-treatment
An instrument for estimating the 6-month survival probability after whole-brain irradiation alone for cerebral metastases from...
TY - JOUR. T1 - An instrument for estimating the 6-month survival probability after whole-brain irradiation alone for cerebral metastases from gynecological cancer. AU - Janssen, Stefan. AU - Hansen, Heinke C.. AU - Schild, Steven E.. AU - Rades, Dirk. PY - 2018/6/1. Y1 - 2018/6/1. N2 - Background/Aim: Patients with cerebral metastases from gynecological cancer who receive whole-brain irradiation (WBI) alone require personalized therapy. This study contributes to personalized care by creating an instrument to predict 6-month survival probability. Patients and Methods: In 49 patients, six pre-treatment variables, namely age, Eastern Cooperative Oncology Group performance score (ECOG-PS), primary tumor type, number of cerebral metastases, metastasis outside the brain, and interval between diagnosis of gynecological cancer and WBI, were analyzed for survival. Results: Of the six pre-treatment variables, ECOG-PS was significantly associated with survival (p=0.014) and metastasis outside the brain ...
https://mayoclinic.pure.elsevier.com/en/publications/an-instrument-for-estimating-the-6-month-survival-probability-aft
Brainlab Raises Awareness about Radiosurgery for Brain Metastases Patients on World Cancer Day 2017 - BrainlabBrainlab Raises Awareness about Radiosurgery for Brain Metastases Patients on World Cancer Day 2017 - Brainlab
Munich, February 3, 2017-In support of World Cancer Day 2017, which aims to bring global attention to cancer, Brainlab, a leader in cancer-fighting technologies, raises awareness about metastatic brain cancer and the revolutionary new methods being used to treat the disease. According to the World Health Organization (WHO), 14 million new cases of cancer are diagnosed every year, with that number expected to rise by 70% over the next two decades. Cancers of the lung, breast, skin, colon and kidney present the highest risk of metastasizing to the brain.. As treatments improve, in combination with early detection, cancer patients are living longer, resulting in higher incidence of brain metastases, according to the American Brain Tumor Association (ABTA). One of the most prevalent procedures for treating multiple brain metastases is whole brain radiation therapy (WBRT) despite increasing evidence that WBRT can lead to significant cognitive side effects and the existence of alternative, less severe ...
https://www.brainlab.com/bp/press-releases/brainlab-raises-awareness-about-radiosurgery-for-brain-metastases-patients-on-world-cancer-day-2017/
How to impart brain tumor treatment in India
Brain is used for almost every function of the body. It is related to the work of most of the parts. It controls and coordinates the actions and allows us to think and feel. It processes information that is received from different parts of the body and the way how we react is dependent on brain only. It is considered as the most complex organ in the body. It consists of billions of neurons which are connected by synapses to several other neurons. There are some conditions and disorders related to this part which stops it from working properly and affect the whole body. Brain tumor is one of those conditions. Brain tumor treatment hospital in India diagnoses the symptoms and treats according to the severity of the condition.. It is the condition in which there is growth of abnormal cells or mass in the brain. Tumors are of different types. They can either be benign which means they are non cancerous or can be malignant which means they have the potential to spread to different parts of the body. ...
http://www.blkhospital.ug/blogview-subject-How-to-impart-brain-tumor-treatment-in-India--id-8.php
Aerobic Glycolysis as a Marker of Tumor Aggressiveness: Preliminary Data in High Grade Human Brain TumorsAerobic Glycolysis as a Marker of Tumor Aggressiveness: Preliminary Data in High Grade Human Brain Tumors
|i|Objectives.|/i| Glucose metabolism outside of oxidative phosphorylation, or aerobic glycolysis (AG), is a hallmark of active cancer cells that is not directly measured with standard |sup|18|/sup|F-fluorodeoxyglucose (FDG) positron emission tomography (PET). In this study, we characterized tumor regions with elevated AG defined based on PET measurements of glucose and oxygen metabolism.|i| Methods.|/i| Fourteen individuals with high-grade brain tumors underwent structural MR scans and PET measurements of cerebral blood flow (CBF), oxygen (CMRO|sub|2|/sub|) and glucose (CMRGlu) metabolism, and AG, using |sup|15|/sup|O-labeled CO, O|sub|2|/sub| and H|sub|2|/sub|O, and FDG, and were compared to a normative cohort of 20 age-matched individuals.|i| Results.|/i| Elevated AG was observed in most high-grade brain tumors and it was associated with decreased CMRO|sub|2|/sub| and CBF, but not with significant changes in CMRGlu. Elevated AG was a dramatic and early sign of tumor growth associated with decreased
https://www.hindawi.com/journals/dm/2015/874904/
Brain Tumor Treatments | Treatment Options for Brain Tumor | RGCIRCBrain Tumor Treatments | Treatment Options for Brain Tumor | RGCIRC
Brain tumour treatment depends on various factors, such as size and location of the tumour, as well as the patients age and heath. The treatment options are differs for adults and children. Visit here to know more.
https://www.rgcirc.org/blog/brain-tumor-treatment/
Nanoparticle-Based MRI for First-In-Man Immune-Therapy Trials in Brain Tumor PatientsNanoparticle-Based MRI for First-In-Man Immune-Therapy Trials in Brain Tumor Patients
This neurosurgeon and neuroradiologist team will determine whether a new non-invasive MRI imaging technique can reveal innate immune cells presence in deadly brain tumors in children and adults, and can be used to assess responses to an experimental immunotherapy that is soon to undergo human clinical testing. Prognoses for malignant brain tumors in children and adults remain stubbornly poor, with a life expectancy of about one year, despite decades of vigorous research on experimental treatments. Prior research has demonstrated that innate (first line of defense) immune cells called macrophages infiltrate brain tumors; in fact, they make up 30-70 percent of brain tumor tissue. The degree of macrophage infiltration has been found to relate to overall survival in a few types of cancers including breast cancers and Hodgkins lymphoma, and in a type of brain tumor called malignant-astrocytoma. Despite the abundant macrophage presence in brain tumors, no current immunotherapy has employed the use ...
http://dana.org/Media/GrantsDetails.aspx?id=115677
role of magnetic resonance spectroscopy in differentiation between recurrent brain neoplasms versus postradiation effects for...role of magnetic resonance spectroscopy in differentiation between recurrent brain neoplasms versus postradiation effects for...
Thesis, English, role of magnetic resonance spectroscopy in differentiation between recurrent brain neoplasms versus postradiation effects for Amin Mai Hafez Abbas
http://www.philadelphia.edu.jo/newlibrary/eng/english-books/671-english-books/102252-engb-102252
Management of patients with newly diagnosed malignant primary brain tu | TCRMManagement of patients with newly diagnosed malignant primary brain tu | TCRM
Management of patients with newly diagnosed malignant primary brain tumors with a focus on the evolving role of temozolomide Mark R Gilbert1, Terri S Armstrong21Department of Neuro-Oncology, The University of Texas MD, Anderson Cancer Center, Houston, TX, USA; 2Department of Integrated Nursing Care, University of Texas Science Center â School of Nursing, Houston, TX, USAAbstract: The prognosis for patients with newly diagnosed malignant gliomas remains poor; however there have been some recent advances in treatment that have generated optimism. Medical management usually includes administration of corticosteroids to control peritumoral edema. Anticonvulsants are indicated for patients with established tumor-related seizures; however, the prophylactic use of anticonvulsants remains controversial. Advances in neurosurgical techniques have improved the safety of tumor resection and most patients undergo the maximal safe surgical debulking of tumor. The tissue sample obtained provides conclusive
https://www.dovepress.com/management-of-patients-with-newly-diagnosed-malignant-primary-brain-tu-peer-reviewed-article-TCRM
Superiority of PCNU over AZQ in the treatment of primary brain tumors: results of a prospective randomized trial (81-20) by the...
TY - JOUR. T1 - Superiority of PCNU over AZQ in the treatment of primary brain tumors. T2 - results of a prospective randomized trial (81-20) by the brain tumor study group. AU - Malkin, Mark G.. AU - Green, Sylvan B.. AU - Byar, David P.. AU - Strike, Thomas A.. AU - Burger, Peter C.. AU - Vogel, F. Stephen. AU - Pistenmaa, David A.. AU - Mahaley, M. Stephen. AU - Ransohoff, Joseph. AU - Shapiro, William R.. AU - Mealey, John. AU - Robertson, James T.. AU - Selker, Robert G.. AU - Van Gilder, John C.. PY - 1994/2. Y1 - 1994/2. N2 - Purpose: A two-arm randomized clinical trial was performed to determine the efficacy of PCNU and AZQ in the treatment of de novo or recurrent primary brain tumors. An additional objective was to gather information on the administration and toxicity of these compounds, supplementing that obtained previously in phase I/II studies. Methods: During 1982 and 1983 the Brain Tumor Study Group randomized 152 adult patients with primary brain tumors to receive PCNU 75-100 ...
https://jhu.pure.elsevier.com/en/publications/superiority-of-pcnu-over-azq-in-the-treatment-of-primary-brain-tu-4
Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors | BMC Cancer | Full TextBrain metastases from hepatocellular carcinoma: clinical features and prognostic factors | BMC Cancer | Full Text
Brain metastases (BM) from hepatocellular carcinoma (HCC) are extremely rare and are associated with a poor prognosis. The aim of this study was to define clinical outcome and prognostic determinants in patients with BM from HCC. Between January 1994 and December 2009, all patients with HCC and BM treated in Sun Yat-sen University Cancer Center were retrospectively reviewed. Univariate and multivariate survival analyses were performed to identify possible prognostic factors. Forty-one patients were diagnosed with BM from HCC, an incidence of 0.47%. The median age at diagnosis of BM was 48.5 years. Thirty-three patients (80.5%) developed extracranial metastases at diagnosis of BM, and 30 patients (73.2%) had hepatitis B. Intracranial hemorrhage occurred in 19 patients (46.3%). BM were treated primarily either with whole brain radiation therapy (WBRT; 5 patients), stereotactic radiosurgery (SRS; 7 patients), or surgical resection (6 patients). The cause of death was systemic disease in 17 patients and
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-12-49
Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors | BMC Cancer | Open peer reviewBrain metastases from hepatocellular carcinoma: clinical features and prognostic factors | BMC Cancer | Open peer review
Brain metastases (BM) from hepatocellular carcinoma (HCC) are extremely rare and are associated with a poor prognosis. The aim of this study was to define clinical outcome and prognostic determinants in patients with BM from HCC. Between January 1994 and December 2009, all patients with HCC and BM treated in Sun Yat-sen University Cancer Center were retrospectively reviewed. Univariate and multivariate survival analyses were performed to identify possible prognostic factors. Forty-one patients were diagnosed with BM from HCC, an incidence of 0.47%. The median age at diagnosis of BM was 48.5 years. Thirty-three patients (80.5%) developed extracranial metastases at diagnosis of BM, and 30 patients (73.2%) had hepatitis B. Intracranial hemorrhage occurred in 19 patients (46.3%). BM were treated primarily either with whole brain radiation therapy (WBRT; 5 patients), stereotactic radiosurgery (SRS; 7 patients), or surgical resection (6 patients). The cause of death was systemic disease in 17 patients and
https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-12-49/open-peer-review
Cancer and brain tumors : - Med Notes
metastatic brain tumors are malignant.. - Primary brain tumors - gliomas. About 80% of primary malignant brain tumors known as gliomas.It is not any particular type of cancer, but the term is used to describe tumors that arise from glial cells (glia or glial cells - These cells surround nerve cells and play a supportive role, glial cells, except microglia have common features and some common origin,they constitute microenvironment specific to neurons, providing conditions for the transmission of nerve impulses).Glial cells are the building blocks of the connective tissue or supporting cells in the central nervous system (CNS).. gliomas are divided into four classes, which reflect the degree of malignancy.Classes (degree) I and II are considered low-grade, and classes III and IV - full-fledged.Classes I and II - with the slowest and least malignant.Class III malignant tumors and is considered to grow at a moderate rate.Class IV malignant - tumor such as glioblastoma, the most rapidly growing and ...
http://mednotess.com/en/pages/1423591
Metastatic brain tumor | University of Maryland Medical CenterMetastatic brain tumor | University of Maryland Medical Center
Treatment depends on the size and type of the tumor, from where in the body it spread, and the persons general health. The goals of treatment may be to relieve symptoms, improve functioning, or provide comfort.. Radiation to the whole brain is often used to treat tumors that have spread to the brain, especially if there are many tumors.. Surgery may be used when there is a single tumor and the cancer has not spread to other parts of the body. Some tumors may be completely removed. Tumors that are deep or that extend into brain tissue may be reduced in size (debulked).. Surgery may reduce pressure and relieve symptoms in cases when the tumor cannot be removed.. Chemotherapy for metastatic brain tumors is usually not as helpful as surgery or radiation. Some types of tumors, though, do respond to chemotherapy.. Stereotactic radiosurgery may also be used. This form of radiation therapy focuses high-power x-rays on a small area of the brain. It is used when there are only a few tumors.. Medicines ...
https://www.umm.edu/Health/Medical/Ency/Articles/Metastatic-brain-tumor
소장자료상세 - 연세대학교 의학도서관소장자료상세 - 연세대학교 의학도서관
Introduction to Brain Tumor Stem Cells -- Isolation and Culture of Glioblastoma Brain Tumor Stem Cells -- Establishment and Culture of Patient-Derived Primary Medulloblastoma Cell Lines -- Bioinformatic Strategies for the Genomic and Epigenomic Characterization of Brain Tumors -- Detecting Stem Cell Marker Expression Using the NanoString nCounter System -- Flow Cytometric Analysis of Brain Tumor Stem Cells -- In Vitro Self-Renewal Assays for Brain Tumor Stem Cells -- Differentiation of Brain Tumor Initiating Cells -- The Study of Brain Tumor Stem Cell Migration -- The Study of Brain Tumor Stem Cell Invasion -- Cell Cycle Dynamics in Glioma Cancer Stem Cells -- Embryonic Stem Cell Models of Human Brain Tumors -- Chromatin Immunoprecipitation (ChIP) Protocols for the Cancer and Developmental Biology Laboratory -- EPH Profiling of BTIC Populations in Glioblastoma Multiforme Using CyTOF -- Pooled Lentiviral CRISPR-Cas9 Screens for Functional Genomics in Mammalian Cells -- In Vitro Assays for ...
https://ymlib.yonsei.ac.kr/catalog/search/book-detail/?rurl=%2Fcatalog%2Fsearch%2F%3Fquery%3DMedicine%2B%26Public_Health_%26si%3DTOTAL%26st%3DFRNT%26sortkey%3Dtitle%26sortorder%3DASC%26bk_0%26bk_3%3Djttj2019jttj%26&cid=CAT000000419725
Use of 5-ALA fluorescence guided endoscopic biopsy of a deep-seated primary malignant brain tumor: Technical note<...Use of 5-ALA fluorescence guided endoscopic biopsy of a deep-seated primary malignant brain tumor: Technical note<...
TY - JOUR. T1 - Use of 5-ALA fluorescence guided endoscopic biopsy of a deep-seated primary malignant brain tumor. T2 - Technical note. AU - Ritz, Rainer. AU - Feigl, Guenther C.. AU - Schuhmann, Martin U.. AU - Ehrhardt, André. AU - Danz, Soeren. AU - Noell, Susan. AU - Bornemann, Antje. AU - Tatagiba, Marcos S.. PY - 2011/1/1. Y1 - 2011/1/1. N2 - The introduction of fluorescence-guided resection of primary malignant brain tumors was a milestone in neurosurgery. Deep-seated malignant brain tumors are often not approachable for microsurgical resection. For diagnosis and therapy, new strategies are recommended. The combination of endoscopy and 5-aminolevulinic acid-induced protoporphyrin IX (5-ALA-induced Pp IX) fluorescence-guided procedures supported by neuronavigation seems an interesting option. Here the authors report on a combined approach for 5-ALA fluorescence-guided biopsy in which they use an endoscopy system based on an Xe lamp (excitation approximately λ = 407 nm; dichroic filter ...
https://scholars.houstonmethodist.org/en/publications/use-of-5-ala-fluorescence-guided-endoscopic-biopsy-of-a-deep-seat
Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases - CareAcross
This phase I trial studies the side effects and best dose of trametinib with or without whole brain radiation therapy in treating patients with brain metastases. Trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy x rays to kill tumor cells. Drugs, such as trametinib, may make tumor cells more sensitive to radiation therapy. Giving trametinib with whole brain radiation therapy may be an effective treatment for brain metastases.
https://www.careacross.com/clinical-trials/trial/NCT02015117
Brain Tumour Tissue Bank
When you fundraise for Brain Tumour Foundation of Canada, one of the many things that you are helping to fund is the Brain Tumour Tissue Bank. Brain Tumour Foundation of Canada is the sole funder of the Brain Tumour Tissue Bank, which is housed in state-of-the-art facilities located at University Hospital, London Health Sciences Centre, London, Ontario.. We recently went on a tour of the facility, which is located close to the surgery theatres to ensure that tissue samples are collected and processed as quickly as possible.. The Brain Tumour Tissue Bank started when Iain, a nine year old boy, became ill with an inoperable brain stem tumour. His family realized that there was no cure and that research was the only way to find a cure. The Brain Tumour Tissue Bank officially opened on June 10, 1991, the first anniversary of Iains death ...
http://blog.braintumour.ca/2016/06/brain-tumour-tissue-bank/
Whole-Brain Radiation Therapy for Brain MetastasisWhole-Brain Radiation Therapy for Brain Metastasis
Whole-brain radiation therapy (WBRT) delivers radiation treatments to the entire brain over a period of many weeks. WBRT is typically used if there are more than a few areas of cancer in the brain. WBRT helps to shrink the tumors and improve symptoms. WBRT also may be used in place of, or in addition to, stereotactic radiosurgery. The side effects of WBRT include thought and memory problems, so its important to have a conversation with your doctor to weigh the risks and benefits of WBRT in your situation. If you have HER2-positive breast cancer that has moved into the brain, you may be able to delay whole-brain radiation therapy by using the combination of Tykerb (chemical name: lapatinib) and Xeloda (chemical name: capecitabine). For more information, see Targeted Therapies to Treat Recurrent and Metastatic Breast Cancer. ...
https://www.breastcancer.org/symptoms/types/recur_metast/treat_metast/options/local/brain/radiation
Brain Tumor Treatment In Kigali, Brain Tumor Treatment Hospital Cost KigaliBrain Tumor Treatment In Kigali, Brain Tumor Treatment Hospital Cost Kigali
Know the cost of Brain Tumor Treatment in Kigali. HEALGURU INDIA is associated with best Brain Tumor Treatment Hospital in Kigali and top surgeons in Kigali. Book your appointment now
https://www.healguru.in/brain-tumor-treatment-in-kigali.html
Survival after surgery and stereotactic radiosurgery for patients with multiple intracranial metastases: Results of a single...Survival after surgery and stereotactic radiosurgery for patients with multiple intracranial metastases: Results of a single...
TY - JOUR. T1 - Survival after surgery and stereotactic radiosurgery for patients with multiple intracranial metastases. T2 - Results of a single-center retrospective study. AU - Smith, Timothy R.. AU - Lall, Rohan R.. AU - Lall, Rishi Rajiv. AU - Abecassis, Isaac Josh. AU - Arnaout, Omar M.. AU - Marymont, Mary Anne H.. AU - Swanson, Kristin R.. AU - Chandler, James P.. PY - 2014/10/1. Y1 - 2014/10/1. N2 - Object. Patients with systemic cancer and a single brain metastasis who undergo treatment with resection plus radiotherapy live longer and have a better quality of life than those treated with radiotherapy alone. Historically, whole-brain radiotherapy (WBRT) has been the mainstay of radiation therapy; however, it is associated with significant delayed neurocognitive sequelae. In this study, the authors looked at survival in patients with single and multiple intracranial metastases who had undergone surgery and adjuvant stereotactic radiosurgery (SRS) to the tumor bed and synchronous ...
https://researchexperts.utmb.edu/en/publications/survival-after-surgery-and-stereotactic-radiosurgery-for-patients
high grade glioma classification [Operative Neurosurgery]high grade glioma classification [Operative Neurosurgery]
High grade glioma classification The term malignant or high grade glioma refers to tumors that are classified as: ●WHO Grade 3 glioma: Anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma, anaplastic ependymoma ● Grade 4 (glioblastoma multiforme) ---------- see Pediatric high grade glioma. Brainstem high grade glioma Cystic high grade glioma Pediatric high grade glioma Recurrent high grade glioma Temporal lobe high grade glioma Thalamic high grade glioma…
https://operativeneurosurgery.com/doku.php?id=high_grade_glioma_classification
Simultaneously integrated boost to multiple brain metastases during whole brain radiation therapy-hippocampal avoidance<...Simultaneously integrated boost to multiple brain metastases during whole brain radiation therapy-hippocampal avoidance<...
TY - CHAP. T1 - Simultaneously integrated boost to multiple brain metastases during whole brain radiation therapy-hippocampal avoidance. AU - Gutiérrez, Alonso N.. AU - Tomé, Wolfgang A.. AU - Ghia, Amol. AU - Thomas, Sayana. AU - Cannon, George. AU - Khuntia, Deepak. AU - Kuo, John S.. AU - Mehta, Minesh. PY - 2010/3/19. Y1 - 2010/3/19. N2 - Purpose: To evaluate the feasibility of delivering a radiosurgery-quality integrated boost to visible brain metastases combined with hippocampal sparing whole brain radiotherapy using helical tomotherapy. Materials and Methods: Ten patients were planned on helical tomotherapy using MR-CT fusion-defined target and normal structure contours. Individually contoured hippocampi were used as conformal avoidance structures and limited to a mean-NTD2 of 6 Gy, where NTD2 denotes the normalized total dose delivered in 2 Gy fractions assuming an α/β-ratio of 2 Gy. A whole brain dose of 32.25 Gy and simultaneous boost doses to brain metastases of either 63.0 Gy (, ...
https://einstein.pure.elsevier.com/en/publications/simultaneously-integrated-boost-to-multiple-brain-metastases-duri-2
Medullary Carcinoma Thyroid with Intracranial Metastasis | OGH ReportsMedullary Carcinoma Thyroid with Intracranial Metastasis | OGH Reports
Abstract:. Thyroid carcinoma with metastatic intracranial involvement is very rare. Intracranial metastases occur in ,1% of all cases. Even in thyroid carcinoma medullary carcinoma with intracranial metastasis is extremely rare. This is a case report of 58-year-old male presenting with scalp swelling over the left fronto parietal region, which was diagnosed as medullary carcinoma thyroid with intracranial metastases. This case presented because of it rarity of presentation.. ...
http://oghreports.org/article/159
Radiosurgery or whole-brain radiation in patients with multiple brain metastases? | Science CodexRadiosurgery or whole-brain radiation in patients with multiple brain metastases? | Science Codex
Although targeted therapies have produced dramatic advances in our ability to control some types of advanced lung cancer, growth of the disease in the brain remains a major problem. Radiation is often used to treat deposits in the brain, but the best technique to deliver radiation can be controversial. Whole-brain radiation therapy, as its name suggest, treats the entire brain but can be associated with notable cognitive side effects. Another strategy, radiosurgery, directs highly-focused radiation only to the sites of metastasis, largely sparing the normal brain. The challenge has been to define in which circumstances each technique is best. The debate has centered on the number of brain metastases, with the field generally agreeing that with three or fewer deposits, radiosurgery is the preferred approach, and then switching to the use of whole-brain radiation to treat four or more deposits.. A University of Colorado Cancer Center study published today in the Journal of Thoracic Oncology ...
http://www.sciencecodex.com/radiosurgery-or-whole-brain-radiation-patients-multiple-brain-metastases-617847
Whole Brain Radiation | Cancer Survivors NetworkWhole Brain Radiation | Cancer Survivors Network
My wife received postoperative whole brain radiation therapy for a single brain metastasis in the Summer of 1998. She began developing brain radiation necrosis within 6-10 months after whole brain radiation, confirmed by an enhanced MRI in June of 1999. Her radiation-induced brain necrosis could have been focal or diffuse, depending on the modality of treatment. The five fractions of focal radiation to the local tumor bed could have resulted in either focal necrosis around the tumor bed or metastatic recurrance. In her case she developed metastatic recurrance as per Pet Scan of August 2000 showing abnormal foci of radiotracer accumulation within the right cerebellar hemisphere, right cerebellopontine angle, pons and base of the fourth ventricle consistent with new metastatic foci. Her previous tumor resection of July 1998, was a 3.5cm necrotic mass in the right cerebellar hemisphere. Recurrance of a cerebral metastasis was very likely to happen in the future. It did, observed via an enhanced MRI ...
https://csn.cancer.org/comment/494616
A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy. | Tempol.infoA phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy. | Tempol.info
Clin Cancer Res. 2004 Oct 1;10(19):6411-7. A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy. Metz JM¹, Smith D, Mick R, Lustig R, Mitchell J, Cherakuri M, Glatstein E, Hahn SM. ¹Department of Radiation Oncology, University of Pennsylvania, Philadelphia Abstract PURPOSE: Complete alopecia is a universal complication of whole brain radiation therapy which contributes to patient anxiety over treatment. Tempol, a nitroxide radioprotector, has been shown to protect against radiation-induced alopecia in an animal model. This phase Ib study was designed to evaluate the safety and side effect profile of topical Tempol in patients with brain metastases being treated with whole brain radiotherapy. EXPERIMENTAL DESIGN: Twelve patients with metastatic cancer to the brain were enrolled in the study between October 2000 and February 2003. Tempol (70 mg/ml concentration solution) was applied topically to the scalp 15 minutes before and washed off immediately
http://tempol.info/a-phase-i-study-of-topical-tempol-for-the-prevention-of-alopecia-induced-by-whole-brain-radiotherapy/
Clinical Analysis of Gamma Knife Radiosurgery for Brain Metastases.Clinical Analysis of Gamma Knife Radiosurgery for Brain Metastases.
Brain metastases from systemic cancer remains a significant source of morbidity and mortality. The clinical results of gamma knife radiosurgery for brain metastases are analyzed to identify treatment parameters and ascertain effectiveness correlated with local tumor control. Between May 1990 and August 1993, 103 patients with brain metastases were treated with gamma knife radiosurgery. Forty four patients had single metastasis. But the rest of the patients had multiple brain metastases: two lesions in 22 patients, three lesions in 13 patients, and more than four lesions in 24 patients. They were expected to survive more than three months and their Karnofsky performance scores were 70% or more. Fifty nine patients underwent radiosurgery only. Seventeen patients had received adjuvant whole brain radiotherapy(WBRT) with radiosurgery. Among 27 patients who underwent tumor resection and radiosurgery, 10 patients had received combined WBRT also. Despite of 91.6% of local tumor control, overall median ...
https://www.jkns.or.kr/journal/view.php?number=3475
Tarceva With Whole Brain Radiation Therapy - Brain Mets From Non-Small Cell Lung CancerTarceva With Whole Brain Radiation Therapy - Brain Mets From Non-Small Cell Lung Cancer
The goal of this clinical research study is to learn whether Tarceva (erlotinib hydrochloride), when given in addition to whole brain radiation therapy,
http://www.knowcancer.com/cancer-trials/NCT00871923/
Best Malignant Astrocytoma Doctor in Delhi NCR, Malignant Astrocytoma Doctors | CredihealthBest Malignant Astrocytoma Doctor in Delhi NCR, Malignant Astrocytoma Doctors | Credihealth
Find the best malignant astrocytoma doctors in Delhi NCR. Get guidance from medical experts to select malignant astrocytoma specialist in Delhi NCR from trusted hospitals - credihealth.com
https://www.credihealth.com/doctors/delhi-ncr/malignant-astrocytoma
Anti-cancer Therapies in High Grade Gliomas | Bentham ScienceAnti-cancer Therapies in High Grade Gliomas | Bentham Science
Title:Anti-cancer Therapies in High Grade Gliomas. VOLUME: 10 ISSUE: 3. Author(s):Cristiana Pistol Tanase, Ana-Maria Enciu, Simona Mihai, Ana Iulia Neagu, Bogdan Calenic and Maria Linda Cruceru. Affiliation:Victor Babes National Institute of Pathology, Dept. of Biochemistry-Proteomics, no 99-101 Splaiul Independentei, 050096 sect 5 Bucharest, Romania.. Keywords:Antiangiogenic therapy, cancer stem cells, glioma, microRNA, personalized medicine, PI-3K.. Abstract:High grade gliomas represent one of the most aggressive and treatment-resistant types of human cancer, with only 1-2 years median survival rate for patients with grade IV glioma. The treatment of glioblastoma is a considerable therapeutic challenge; combination therapy targeting multiple pathways is becoming a fast growing area of research. This review offers an up-to-date perspective of the literature about current molecular therapy targets in high grade glioma, that include angiogenic signals, tyrosine kinase receptors, nodal signaling ...
https://www.eurekaselect.com/116666/article?tracking-code=4
Whole brain radiotherapy - WikipediaWhole brain radiotherapy - Wikipedia
Whole brain radiotherapy (WBRT) is a palliative option for patients with brain metastases that alleviates symptoms, decreases the use of corticosteroids needed to control tumor-associated edema, and potentially improves overall survival. It has been reported to increase the risk of cognitive decline. McTyre, E; Scott, J; Chinnaiyan, P (2013). Whole brain radiotherapy for brain metastasis. Surg Neurol Int. 4: S236-44. doi:10.4103/2152-7806.111301. PMC 3656558 . PMID 23717795. Whole-Brain Radiotherapy: Risks Worth Benefit?. Medscape.com. Retrieved August 20, 2015 ...
https://en.wikipedia.org/wiki/Whole_brain_radiotherapy
Efficacy and toxicity of whole brain radiotherapy in patients with multiple cerebral metastases from malignant melanoma |...Efficacy and toxicity of whole brain radiotherapy in patients with multiple cerebral metastases from malignant melanoma |...
To retrospectively access outcome and toxicity of whole brain radiotherapy (WBRT) in patients with multiple brain metastases (BM) from malignant melanoma (MM). Results of 87 patients (median age 58 years; 35 female, 52 male) treated by WBRT for BM of MM between 2000 and 2011 were reviewed. Total dose applied was either 30 Gy in 10 fractions (n = 56) or 40 Gy in 20 fractions (n = 31). All but 9 patients suffered from extra-cerebral metastases. Prior surgical resection of BM was performed in 18 patients, salvage stereotactic radiosurgery in 13 patients. Mean follow-up was 8 months (range, 0-57 months), the 6- and 12-months overall-(OS) survival rates were 29.2% and 16.5%, respectively. The median OS was 3.5 months. In cerebral follow-up imaging 6 (11) patients showed a complete (partial) remission, while 11 (17) patients had stable disease (intra-cerebral tumor progression). In comparison of total dose, the group treated with 40 Gy in 20 fractions achieved a significant longer OS (p = 0.003, median 3.1 vs
https://ro-journal.biomedcentral.com/articles/10.1186/1748-717X-7-130
Spontaneous haemorrhage into metastatic brain tumours after stereotactic radiosurgery using a linear accelerator | Journal of...Spontaneous haemorrhage into metastatic brain tumours after stereotactic radiosurgery using a linear accelerator | Journal of...
The effect of radiosurgery on spontaneous haemorrhage into metastatic brain tumours has not been sufficiently investigated. This study showed that haemorrhage was observed in 7.4% of patients (3.8% of tumours) before radiosurgery and in 18.5% of patients (7.6% of tumours) after radiosurgery. This would not necessarily imply that radiosurgery increases the likelihood of haemorrhage, as the incidence of intratumour haemorrhage is quite different between the early and later stages of brain metastases, which grow very rapidly. Rather, the incidence of haemorrhage after radiosurgery (18.5%) was no greater than that of untreated tumours reported previously (0-50%).3 However, it is not possible to state definitively whether radiosurgery increases, does not change, or decreases the risk of haemorrhage, because of the lack of a control group. However, 50% of the observed haemorrhages occurred within one month of the procedure. As most haemorrhagic tumours were under good local control at the time of the ...
http://jnnp.bmj.com/content/74/7/908
Preoperative embolization of hypervascular pediatric brain tumors: Evaluation of technical safety and outcome<...
TY - JOUR. T1 - Preoperative embolization of hypervascular pediatric brain tumors. T2 - Evaluation of technical safety and outcome. AU - Wang, Hsueh Han. AU - Luo, Chao Bao. AU - Guo, Wan Yuo. AU - Wu, Hsiu Mei. AU - Lirng, Jiing Feng. AU - Wong, Tai-Tong. AU - Lu, Yueh Hsun. AU - Chang, Feng Chi. PY - 2013/11/1. Y1 - 2013/11/1. N2 - Background: Surgical management of pediatric hypervascular brain tumors is challenging because of the risk of bleeding. We sought to evaluate the technical factors associated with safety and outcome of preoperative embolization of pediatric hypervascular brain tumors. Materials and methods: Eight pediatric brain tumor patients received preoperative endovascular embolization during the past 8 years. The cases included four choroid plexus papillomas, one yolk sac tumor, one intraventricular meningioma, one astrocytoma, and one hemangioblastoma. Embolization was done by superselection of the feeding arteries with microcatheters followed by slow injection of either ...
https://tmu.pure.elsevier.com/zh/publications/preoperative-embolization-of-hypervascular-pediatric-brain-tumors
Stereotactic radiosurgery for patients with multiple brain metastases: a case-matched study comparing treatment results for...
TY - JOUR. T1 - Stereotactic radiosurgery for patients with multiple brain metastases. T2 - a case-matched study comparing treatment results for patients with 2-9 versus 10 or more tumors. AU - Yamamoto, Masaaki. AU - Kawabe, Takuya. AU - Sato, Yasunori. AU - Higuchi, Yoshinori. AU - Nariai, Tadashi. AU - Watanabe, Shinya. AU - Kasuya, Hidetoshi. PY - 2014/12/1. Y1 - 2014/12/1. N2 - OBJECT: Although stereotactic radiosurgery (SRS) alone is not a standard treatment for patients with 4-5 tumors or more, a recent trend has been for patients with 5 or more, or even 10 or more, tumors to undergo SRS alone. The aim of this study was to reappraise whether the treatment results for SRS alone for patients with 10 or more tumors differ from those for patients with 2-9 tumors.METHODS: This was an institutional review board-approved, retrospective cohort study that gathered data from the Katsuta Hospital Mito GammaHouse prospectively accumulated database. Data were collected for 2553 patients who ...
https://keio.pure.elsevier.com/en/publications/stereotactic-radiosurgery-for-patients-with-multiple-brain-metast-2
Prognostic factors and survival patterns in pediatric low-grade gliomas over 4 decades<...
TY - JOUR. T1 - Prognostic factors and survival patterns in pediatric low-grade gliomas over 4 decades. AU - Youland, Ryan S.. AU - Khwaja, Shariq S.. AU - Schomas, David A.. AU - Keating, Gesina F.. AU - Wetjen, Nicholas M.. AU - Laack, Nadia N.. PY - 2013/4/1. Y1 - 2013/4/1. N2 - BACKGROUND:: This study reports changes in long-term survival after the introduction of modern imaging in pediatric patients with low-grade gliomas (LGGs). METHODS:: Records from 351 consecutive pediatric patients diagnosed with LGG between 1970 and 2009 at Mayo Clinic Rochester were reviewed and divided into diagnosis before (group I: 1970 to 1989) and after (group II: 1990 to 2009) postoperative magnetic resonance imaging became regularly used in pediatric LGG. RESULTS:: Median progression-free survival (PFS) and overall survival (OS) were not reached. Overall, 10-year PFS was 62% and OS was 90%. On multivariate analysis, improved PFS was associated with gross total resection (GTR; P,0.0001) and postoperative ...
https://mayoclinic.pure.elsevier.com/en/publications/prognostic-factors-and-survival-patterns-in-pediatric-low-grade-g
COMBINED MODALITY TREATMENT INCLUDING METHOTREXATE-BASED CHEMOTHERAPY FOR PRIMARY CEREBRAL NERVOUS SYSTEM LYMPHOMA: A SINGLE...COMBINED MODALITY TREATMENT INCLUDING METHOTREXATE-BASED CHEMOTHERAPY FOR PRIMARY CEREBRAL NERVOUS SYSTEM LYMPHOMA: A SINGLE...
COMBINED MODALITY TREATMENT INCLUDING METHOTREXATE-BASED CHEMOTHERAPY FOR PRIMARY CEREBRAL NERVOUS SYSTEM LYMPHOMA: A SINGLE INSTITUTION EXPERIENCE
http://mjhid.org/index.php/mjhid/article/view/2009.020/64
Pseudoprogression of glioblastoma after chemo- and radiation therapy: Diagnosis by using dynamic susceptibility-weighted...Pseudoprogression of glioblastoma after chemo- and radiation therapy: Diagnosis by using dynamic susceptibility-weighted...
TY - JOUR. T1 - Pseudoprogression of glioblastoma after chemo- and radiation therapy. T2 - Diagnosis by using dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging with ferumoxytol versus gadoteridol and correlation with survival. AU - Gahramanov, Seymur. AU - Muldoon, Leslie. AU - Varallyay, Csanad G.. AU - Li, Xin. AU - Kraemer, Dale. AU - Fu, Rongwei (Rochelle). AU - Hamilton, Bronwyn. AU - Rooney, William. AU - Neuwelt, Edward. PY - 2013/3. Y1 - 2013/3. N2 - Purpose: To compare gadoteridol and ferumoxytol for measurement of relative cerebral blood volume (rCBV) in patients with glioblastoma multiforme (GBM) who showed progressive disease at conventional magnetic resonance (MR) imaging after chemo- and radiation therapy (hereafter, chemoradiotherapy) and to correlate rCBV with survival. Materials and Methods: Informed consent was obtained from all participants before enrollment in one of four institutional review board-approved protocols. Contrast agent leakage maps and rCBV ...
https://ohsu.pure.elsevier.com/en/publications/pseudoprogression-of-glioblastoma-after-chemo-and-radiation-thera-2
Anaplastic astrocytoma - WikipediaAnaplastic astrocytoma - Wikipedia
Anaplastic astrocytoma is a rare WHO grade III type of astrocytoma, which is a type of cancer of the brain. In the United States, the annual incidence rate for Anaplastic astrocytoma is 0.44 per 100,000 persons Anaplastic astrocytomas fall under the category of high grade gliomas (WHO grade III-IV), which are pathologically undifferentiated gliomas that carry a poor clinical prognosis. Unlike glioblastomas (WHO grade IV), anaplastic astrocytomas lack vascular proliferation and necrosis on pathologic evaluation. Compared to grade II tumors, anaplastic astrocytomas are more cellular, demonstrate more atypia, and mitoses are seen. Initial presenting symptoms most commonly are headache, depressed mental status, focal neurological deficits, and/or seizures. The growth rate and mean interval between onset of symptoms and diagnosis is approximately 1.5-2 years but is highly variable, being intermediate between that of low-grade astrocytomas and glioblastomas. Seizures are less common among patients ...
https://en.wikipedia.org/wiki/Anaplastic_astrocytoma
Stereotactic radiosurgery can result in less cognitive deterioration in certain patients - NeuroNews International
The researchers found that there was less cognitive deterioration at 3 months after stereotactic radiosurgery alone (40/63 patients, 64%) than when combined with whole brain radiotherapy (44/48 patients, 92%). Quality of life was higher at three months with stereotactic radiosurgery alone, including overall quality of life. There was no significant difference in functional independence at three months between the treatment groups. Median overall survival was 10.4 months for stereotactic radiosurgery alone and 7.4 months for stereotactic radiosurgery plus whole brain radiotherapy. For long-term survivors, the incidence of cognitive deterioration was less after stereotactic radiosurgery alone at three months and at 12 months.. In the absence of a difference in overall survival, these findings suggest that for patients with one to three brain metastases amenable to radiosurgery, stereotactic radiosurgery alone may be a preferred strategy, the authors write.. The debate between whole brain ...
https://neuronewsinternational.com/stereotactic-radiosurgery-can-result-in-less-cognitive-deterioration-in-certain-patients/
Brain Tumors
Allexperts Brain Tumors Q&A Prominent doctors and others answer your detailed one-on-one questions about brain tumors and cancers for free.. Sutter Gamma Knife Radiosurgery Center provides non-invasive, stereotactic radiosurgery treatment for tumors, neuromas, arteriovenous malformations, Parkinsons Disease and other brain disorders.. NYU Neurosurgery Information about brain tumors, spine disorders, functional neurosurgery and radiosurgery. Clinical Trials And Noteworthy Treatments For Brain Tumors - Brain tumor treatment information. What You Need to Know about Brain Tumors A booklet from the National Cancer Institute on brain tumors. Pacific Neurosurgical Associates treatments for disorders of the brain and spine, brain tumors, and epilepsy.. Wake Forest University Neurosurgery Presents comprehensive links to neurosurgical treatments such as the Gamma Knife and to diseases such as Parkinsons and brain tumors.. The Rory David Deutsch Foundation The Rory David Deutsch Foundation is dedicated to ...
http://ability.org.uk/Brain_Tumors.html
Indian Journal of Medical and Paediatric OncologyIndian Journal of Medical and Paediatric Oncology
Background: The atmosphere of valley of Kashmir is ideal for fresh and dry fruit production. Millions of tons of pesticides, insecticides and fungicides (chemicals like chlorpyriphos, mancozeb, captan, dimethoate, phosalone, etc.) are being used by the orchard farmers to spray the plants, fruits and the leaves every year. The increasing trend in the incidence of primary malignant brain tumors in orchard farmers of Kashmir is alarming. Aim: To determine the relationship between the patients of primary malignant brain tumors and their occupation. Materials and Methods: Retrospectively case files along with death certificates of 432 patients of primary malignant brain tumors and 457 controls (non-tumor neurologic diseases), admitted for treatment simultaneously over a period of 4 years from January 2005 to December 2008, to the Department of Neurosurgery, Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Kashmir, were studied. Follow-up and family contact was established. The serum ...
http://www.ijmpo.org/showstats.asp?sabs=y&a=ts
Preoperative diffusion-weighted imaging of single brain metastases correlates with patient survival times - University of...Preoperative diffusion-weighted imaging of single brain metastases correlates with patient survival times - University of...
Berghoff, Anna Sophie, Spanberger, Thomas, Ilhan-Mutlu, Aysegül, Magerle, Manuel, Hutterer, Markus, Woehrer, Adelheid, Hackl, Monika, Widhalm, Georg, Dieckmann, Karin, Marosi, Christine, Birner, Peter, Prayer, Daniela and Preusser, Matthias (2013) Preoperative diffusion-weighted imaging of single brain metastases correlates with patient survival times. PloS one 8 (2), e55464 ...
https://epub.uni-regensburg.de/29107/
PLGA Foundation Sponsors International Low Grade Glioma Symposium - A Kids Brain Tumor Cure Foundation | PLGA Foundation
The June 2012 International Society of Pediatric Neuro Oncology (ISPNO) meeting in Toronto, Canada featuried a Low Grade Glioma (LGG) Symposium. This was the third time the PLGA Foundation had sponsored a targeted session at ISPNO and interest in the low grade glioma field continues to grow amongst scientists and medical experts because of meeting such as these.. The ISPNO meets once every 2 years and attracts an international audience of over 1000 experts in the clinical and research fields. The exposure that this symposium gives to this disease is immense. The LGG session sold out in the first two weeks with over 200 participants registering. This means that more attention will be focused on the most common forms of childrens brain tumors giving hope to the children battling these tumors for more effective treatments and a cure.. The LGG Session was moderated by Dr. Charles Eberhart, Associate Professor of Oncology, Pathology and Opthomology at Johns Hopkins University School of Medicine, and ...
https://akidsbraintumorcure.org/6081/conferences/plga-foundation-sponsors-international-low-grade-glioma-symposium-2/
Tolerance of awake surgery for glioma: A prospective European Low Grade Glioma Network multicenter study<...
TY - JOUR. T1 - Tolerance of awake surgery for glioma. T2 - A prospective European Low Grade Glioma Network multicenter study. AU - Beez, Thomas. AU - Boge, Kira. AU - Wager, Michel. AU - Whittle, Ian. AU - Fontaine, Denys. AU - Spena, Giannantonio. AU - Braun, Sebastian. AU - Szelényi, Andrea. AU - Bello, Lorenzo. AU - Duffau, Hugues. AU - Sabel, Michael. PY - 2013/7. Y1 - 2013/7. N2 - Background: Gross total removal of glioma is limited by proximity to eloquent brain. Awake surgery allows for intraoperative monitoring to safely identify eloquent regions. However, data on adverse psychological effects induced in these patients is limited. Objective: This study explored patients perception of awake surgery for glioma, with special focus on intraoperative pain and anxiety. Methods: This study was conducted at five neurosurgical centers within the European Low Grade Glioma Network. Patients underwent awake surgery for glioma according to the protocol of the individual center. Pain and discomfort ...
https://moh-it.pure.elsevier.com/en/publications/tolerance-of-awake-surgery-for-glioma-a-prospective-european-low-
AKBTC Sponsored Research Projects - A Kids Brain Tumor Cure Foundation | PLGA Foundation
Pediatric brain tumors are the second most common form of cancer and the leading cause of cancer-related morbidity and mortality in pediatrics. Until recently, the majority of research in pediatric brain tumors was focused on the highly aggressive embryonal tumors, such as medulloblastoma, and there have been recent dramatic advances in the understanding of this subset of tumors.. However, more than half of childhood primary central nervous system tumors are gliomas and, unlike the situation in adulthood, low-grade gliomas constitute most pediatric gliomas. Pediatric low-grade gliomas arise throughout the nervous system and, despite their often indolent nature - dependent on their location in the nervous system - they may not be amenable to safe, extensive resections and can result in significant morbidity and, at times, mortality.. Radiation has been a conventional second step in therapy when surgery is not deemed feasible. In many children, this can result in excellent long-term control, but ...
https://akidsbraintumorcure.org/medical-research-on-childhood-brain-tumors/plga-sponsored-research-projects/
Anaplastic pleomorphic xanthoastrocytoma - Semantic ScholarAnaplastic pleomorphic xanthoastrocytoma - Semantic Scholar
A case of anaplastic pleomorphic xanthoastrocytoma (PXA) in a 9-year-old girl is reported. Histological features of PXAs are cellular pleomorphism of GFAP-positive cells, with intracytoplasmic lipidic vacuoles and a reticulin network, bizarre giant cells, low mitotic activity, and lack of necrosis and of endothelial vascular proliferations. These tumors are generally reported to have a favorable postoperative course. In our case, a poor clinical prognosis and spread of the illness through the CSF was observed. Immunohistochemical features of the tumor, which were histologically anaplastic in nature, were analyzed. There were small foci of necrosis in the sections of the material obtained at the first operation and extensive necrosis in that from the second operation, although the patient had not received radiotherapy between the operations. The presence of necrosis in PXA is an uncommon and significant feature. It predicts the poor prognosis seen in this case, and therefore this report strongly supports
https://www.semanticscholar.org/paper/Anaplastic-pleomorphic-xanthoastrocytoma-Bayindir-Balak/d6fe57c582e5535e192d70047b0bcfca710bc84e
Similar Local Recurrence Rates But Increased Distant Metastases With Adjuvant Localized vs Whole-Brain Radiotherapy in Patients...Similar Local Recurrence Rates But Increased Distant Metastases With Adjuvant Localized vs Whole-Brain Radiotherapy in Patients...
In patients who had undergone surgery for brain metastases, the rate of recurrence at the resected site was similar between patients who received adjuvant whole-brain radiotherapy vs those who underwent adjuvant localized radiotherapy, according to a retrospective study by Hsieh et al in the journal Neurosurgery. However, localized radiotherapy was associated with a higher incidence of distant metastases.. Surgery followed by adjuvant whole-brain radiotherapy is a well-established treatment for brain metastases, particularly in patients who have a limited number of brain metastases. Yet discussions continue as to whether these patients require whole-brain radiotherapy or can be treated with localized radiotherapy. Localized radiotherapy is associated with fewer side effects compared with whole-brain radiotherapy, but some studies have documented an association with an increased risk for development of new intracranial metastases.. Thus, the investigators conducted a study to examine the rate of ...
https://www.ascopost.com/News/24600
Brain metastasis from papillary thyroid carcinomas
Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma and has a relatively favorable prognosis. PTC brain metastases are rare, occurring in 0.1‑5% of cases in previous studies. In the present study, we treated 5 cases of PTC brain metastasis in our institute and retrospectively evaluated these patients. A retrospective database was generated from the patient medical records of our institution for the years between 1976 and 2011. The mean patient age at diagnosis was 64.6 years and the average duration from PTC resection to the detection of a brain metastasis using magnetic resonance imaging (MRI) or computed tomography (CT) was 91.7 months. The patients were treated with various combinations of surgery and radiation therapy. All 5 patients died and the mean overall survival following the diagnosis of a brain metastasis was 9.0 months. One patient succumbed to an intratumoral hemorrhage of the metastatic brain tumor. The remaining patients died following metastasis to ...
https://tessera.spandidos-publications.com/10.3892/mco.2013.139/abstract
Imaging in Glioblastoma Multiforme: Overview, Radiography, Computed TomographyImaging in Glioblastoma Multiforme: Overview, Radiography, Computed Tomography
Glioblastomas (malignant glioma) are the most common adult malignant brain tumors, and 20% of all primary brain neoplasms are glioblastoma multiforme tumors. Glioblastoma multiforme (GBM; malignant glioma) is the highest-grade form of astrocytoma and makes up about two thirds of all brain astrocytomas.
https://emedicine.medscape.com/article/340870-overview

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