Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Brain disorders resulting from inborn metabolic errors, primarily from enzymatic defects which lead to substrate accumulation, product reduction, or increase in toxic metabolites through alternate pathways. The majority of these conditions are familial, however spontaneous mutation may also occur in utero.
Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Systemic lysosomal storage disease caused by a deficiency of alpha-L-iduronidase (IDURONIDASE) and characterized by progressive physical deterioration with urinary excretion of DERMATAN SULFATE and HEPARAN SULFATE. There are three recognized phenotypes representing a spectrum of clinical severity from severe to mild: Hurler syndrome, Hurler-Scheie syndrome and Scheie syndrome (formerly mucopolysaccharidosis V). Symptoms may include DWARFISM; hepatosplenomegaly; thick, coarse facial features with low nasal bridge; corneal clouding; cardiac complications; and noisy breathing.
Any of various diseases affecting the white matter of the central nervous system.
Acquired or inborn metabolic diseases that produce brain dysfunction or damage. These include primary (i.e., disorders intrinsic to the brain) and secondary (i.e., extracranial) metabolic conditions that adversely affect cerebral function.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. Neural stem cells are precursors to both NEURONS and NEUROGLIA.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
A circumscribed collection of purulent exudate in the brain, due to bacterial and other infections. The majority are caused by spread of infected material from a focus of suppuration elsewhere in the body, notably the PARANASAL SINUSES, middle ear (see EAR, MIDDLE); HEART (see also ENDOCARDITIS, BACTERIAL), and LUNG. Penetrating CRANIOCEREBRAL TRAUMA and NEUROSURGICAL PROCEDURES may also be associated with this condition. Clinical manifestations include HEADACHE; SEIZURES; focal neurologic deficits; and alterations of consciousness. (Adams et al., Principles of Neurology, 6th ed, pp712-6)
A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
The means of interchanging or transmitting and receiving information. Historically the media were written: books, journals, newspapers, and other publications; in the modern age the media include, in addition, radio, television, computers, and information networks.
Portable electronics device for storing and playing audio and or media files. MP3 for MPEG-1 audio layer 3, is a digital coding format.
Transmission of information over distances via electronic means.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Discussion of lists of works, documents or other publications, usually with some relationship between them, e.g., by a given author, on a given subject, or published in a given place, and differing from a catalog in that its contents are restricted to holdings of a single collection, library, or group of libraries. (from The ALA Glossary of Library and Information Science, 1983)
A list of works, documents, and other publications on medical subjects and topics of interest to the field of medicine.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.
An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.
Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784)
The units based on political theory and chosen by countries under which their governmental power is organized and administered to their citizens.

Neuropathological findings after bone marrow transplantation: an autopsy study of 180 cases. (1/159)

We prospectively evaluated the neuropathological complications of 180 patients who underwent autopsy studies following bone marrow transplantation (BMT) (177 allogeneic, three autologous). The most frequent underlying disorders included severe aplastic anemia (n = 55), chronic myelogenous leukemia (n = 53), acute myelogenous leukemia (n = 24) and Fanconi anemia (n = 16). There were 114 males and 66 females. Neuropathological findings were detected in 90.55% of the patients. The most frequent findings were subarachnoid hemorrhages (SAH) (n = 57), intraparenchymal hemorrhages (IHP) (n = 49), fungal infections (n = 16), Wernicke's encephalopathy (n = 10), microglial nodular encephalopathy (n = 10) and neurotoxoplasmosis (n = 8). In only 17 patients was the brain within normal limits. Survival time after BMT averaged 5.4 months and the majority of patients died in the first 3 months post BMT (n = 105). Central nervous system (CNS) pathology was the main cause of death in 17% of the patients (n = 31), with a predominance of IHP in this particular group. Furthermore, the survival time of these patients who died of CNS causes (96.3 days) was almost half of the survival time of those who died of extra-cerebral causes (177.8 days) (P = 0.0162). IHP (70. 96 vs27.22%) (P < 0.001), fungal infections (25.8 vs 8.88%) (P < 0. 001) and toxoplasmosis (9.67 vs 4.44%) (P < 0.001) were significantly more frequent in the group of patients who died due to CNS causes than in the control group. The findings of this work provide a possible guide to the possible causes of neurological syndromes following BMT. Bone Marrow Transplantation (2000) 25, 301-307.  (+info)

Bone marrow transplantation corrects osteopetrosis in the carbonic anhydrase II deficiency syndrome. (2/159)

Carbonic anhydrase II (CAII), found in renal tubules, brain, and osteoclasts, is critical in acid-base homeostasis and bone remodeling. Deficiency of CAII gives rise to a syndrome of osteopetrosis, renal tubular acidosis (RTA), and cerebral calcification with associated developmental delay. It is inherited in an autosomal recessive fashion and found most frequently in the Mediterranean region and the Middle East. We report 2 related Irish families with clinically severe CAII deficiency in whom the gene mutation has been fully elucidated. Two children, one from each family, have undergone allogeneic bone marrow transplantation because of severe progressive visual and hearing loss. The older 2 children had already developed cerebral calcification and marked visual loss at the time of diagnosis and were treated symptomatically. Post-transplantation evaluation at 2 and 3 years demonstrates histologic and radiologic resolution of their osteopetrosis with stabilization of hearing and vision. Both children remain developmentally delayed and continue to have RTA, and the older child has now developed cerebral calcification. Allogeneic bone marrow stem cell replacement cures the osteoclast component of CAII deficiency and retards the development of cerebral calcification, but it appears to have little or no effect on the renal lesions. (Blood. 2001;97:1947-1950)  (+info)

Prognostic significance of cerebral metabolic abnormalities in patients with congestive heart failure. (3/159)

BACKGROUND: Cerebral metabolic abnormalities were proposed as a potential marker of disease severity in congestive heart failure (CHF), but their prognostic significance remains uncertain. METHODS AND RESULTS: We investigated the prognostic value of cerebral metabolic abnormalities in 130 consecutive patients with advanced CHF (100 men aged 42.6+/-11.9 years; left ventricular ejection fraction, 22.2+/-6.2%). Proton magnetic resonance spectroscopy data were obtained from localized regions ( approximately 8 mL) of the occipital gray matter and the parietal white matter. The primary end point was the occurrence of death after the proton magnetic resonance spectroscopy. During follow-up (18.5+/-14.4 months), 21 patients died and 15 underwent urgent heart transplantation. In the Cox proportional model, occipital metabolites (N-acetylaspartate, creatine, choline, and myoinositol), parietal N-acetylaspartate level, and the duration of CHF symptoms (>12 months) were validated as univariate predictors of death. In multivariate Cox analyses, however, the occipital N-acetylaspartate level was an independent predictor of death (hazard ratio, 0.52; 95% CI, 0.41 to 0.67; P<0.001). An analysis with respect to the combined end point of death or urgent transplantation showed similar results. The best cutoff value (9.0 mmol/kg) for occipital N-acetylaspartate level had 75% sensitivity and 67% specificity to predict mortality. CONCLUSIONS: The occipital N-acetylaspartate level is a powerful and independent predictor of CHF mortality, suggesting that cerebral metabolic abnormalities may be used as a new prognostic marker in the assessment of patients with CHF.  (+info)

Regression of ventral striatum hypometabolism after calcium/calcitriol therapy in paroxysmal kinesigenic choreoathetosis due to idiopathic primary hypoparathyroidism. (4/159)

A [(18)F]-FDG PET study was performed in a 44 year old man with proximal kinesigenic choreoathetosis (PKC) secondary to idiopathic primary hypoparathyroidism (IPH) before and 1 year after calcium/calcitriol therapy. The [(18)F]-FDG PET performed before the start of the therapy disclosed a significant bilateral hypometabolism in the ventral striatum. One year later, with the patient still under calcium/calcitriol therapy and free of any occurrence of PKC episodes, the [(18)F]-FDG PET did not show the previously detected hypometabolism. The hypometabolism of the ventral striatum secondary to hypocalcaemia seems to play a crucial part in the pathogenesis of paroxysmal kinesigenic choreoathetosis associated with IPH.  (+info)

Non-hepatic hyperammonaemia: an important, potentially reversible cause of encephalopathy. (5/159)

The clinical syndrome of encephalopathy is most often encountered in the context of decompensated liver disease and the diagnosis is usually clear cut. Non-hepatic causes of encephalopathy are rarer and tend to present to a wide range of medical specialties with variable and episodic symptoms. Delay can result in the development of potentially life threatening complications, such as seizures and coma. Early recognition is vital. A history of similar episodes or clinical risk factors and early assessment of blood ammonia levels help establish the diagnosis. In addition to adequate supportive care, investigation of the underlying cause of the hyperammonaemia is essential and its reversal, where possible, will often result in complete recovery. Detection of an unborn error of metabolism should lead to the initiation of appropriate maintenance therapy and genetic counselling.  (+info)

Glucose and oxygen hypometabolism in aceruloplasminemia brains. (6/159)

OBJECTIVE: Aceruloplasminemia is an iron metabolic disorder caused by mutations in the ceruloplasmin gene. It is characterized by progressive neurodegeneration in association with iron accumulation. Excess iron functions as a potent catalyst of biologic oxidation. Previously we showed that an increased iron concentration is associated with the products of lipid peroxidation in the serum, cerebrospinal fluid, and brain tissues. To clarify the free radical-mediated tissue injury caused by intracellular iron accumulation through mitochondrial dysfunction. PATIENTS AND METHODS: We have measure brain oxygen and glucose metabolisms using positron emission tomography (PET) and examined brains at autopsy for iron contents and activities of the mitochondrial respiratory chain in two affected patients who had different truncation mutations of the ceruloplasmin gene. RESULTS: PET showed a marked decrease in glucose and oxygen consumption in the entire brain of aceruloplasminemia patients, with a preponderance of metabolic reduction in basal ganglia. Enzyme activities in the mitochondrial respiratory chain of the basal ganglia were reduced to approximately 45% and 42% respectively for complexes I and IV. An inverse relationship was shown between the amounts of iron accumulated and the levels of mitochondrial enzyme activities in all the brain regions examined. CONCLUSION: Iron-mediated free radicals may contribute to the impairment of mitochondrial energy metabolism in aceruloplasminemia.  (+info)

Fat oxidation defect presenting with overwhelming ketonuria. (7/159)

Ketonuria accompanying hypoglycaemia is conventionally thought to exclude fat oxidation defects. We describe a 2 year old girl with hypoglycaemic encephalopathy in whom a diagnosis of very long chain acyl CoA dehydrogenase deficiency was suggested on the basis of acylcarnitine analysis despite massive ketonuria.  (+info)

Axonal damage: a key predictor of outcome in human CNS diseases. (8/159)

Axonal damage has recently been recognized to be a key predictor of outcome in a number of diverse human CNS diseases, including head and spinal cord trauma, metabolic encephalopathies, multiple sclerosis and other white-matter diseases (acute haemorrhagic leucoencephalitis, leucodystrophies and central pontine myelinolysis), infections [malaria, acquired immunodeficiency syndrome (AIDS) and infection with human lymphotropic virus type 1 (HTLV-I) causing HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP)] and subcortical ischaemic damage. The evidence for axonal damage and, where available, its correlation with neurological outcome in each of these conditions is reviewed. We consider the possible pathogenetic mechanisms involved and how increasing understanding of these may lead to more effective therapeutic or preventive interventions.  (+info)

Looking for Menkes' syndrome? Find out information about Menkes' syndrome. Med any combination of signs and symptoms that are indicative of a particular disease or disorder Syndrome, Mr. Incredibles wannabe sidekick turned bad... Explanation of Menkes' syndrome
At eGroups: Open to anyone interested in making friends, sharing information and providing support for persons affected by Menkes Kinky Hair Syndrome ...
NOAKES, Timothy David. The University of Cape Town taught me how to challenge beliefs. SAMJ, S. Afr. med. j. [online]. 2012, vol.102, n.6, pp.430-432. ISSN 2078-5135.. The worlds first successful human heart transplantation on 2 December 1967 inspired me to study medicine at the University of Cape Towns Faculty of Health Sciences. There I learned 5 key elements for a successful career in either medicine or science or both - perfectionism, passion, compassion, the dispassionate investigation of all the available evidence, and the need to challenge established beliefs for which the scientific evidence appears imperfect. Challenging such beliefs enabled us to prove that hyponatraemic encephalopathy was caused by persistent and heroic over-drinking during prolonged exercise, usually lasting more than 4 hours, and was unrelated to salt losses in sweat and urine; to understand that the brain not the muscles must regulate the exercise performance, and thus develop the Central Governor Model of ...
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If required by your instructor, you can add annotations to your citations. Just select Add Annotation while finalizing your citation. You can always edit a citation as well. ...
Arora, D., Mudgal, J., Nampoothiri, M., Mallik, S. B., Kinra, M., Hall, S., Anoopkumar-Dukie, S., Grant, G. D. & Rao, C. M., 07-03-2018, (Accepted/In press) In : Metabolic Brain Disease. p. 1-7 7 p.. Research output: Contribution to journal › Article › peer-review ...
If required by your instructor, you can add annotations to your citations. Just select Add Annotation while finalizing your citation. You can always edit a citation as well. ...
Posterior Cortical Atrophy disease dementia is a type of dementia, related to Alzheimers disease. Learn about Posterior Cortical Atrophy disease signs and symptoms and treatment and get support resources.
There is no effective common treatment known. Injection of copper has been used with mixed results. Present therapy consists of: Copper acetate administered into a vein (intravenously) and Subcutaneous (injected under the skin) copper histidinate.. Treatment can even begin before birth; while still pregnant, mothers of babies identified with Menkes disease can receive injections of copper histidine under the skin. Healthcare professionals, including geneticists (specialists in hereditary diseases), should be consulted in the treatment of Menkes disease. Seizures, abnormally light pigmentation of the skin and hair. Death usually occurs in the first few years of life. Menkes is a serious disorder with early death being common. ...
Tkachenko, V. I. (2014). Liky Ukrainy, 4, 55-59. Pankiv V. I. (2012). Pathogenetic treatment of Diabetic Neuropathy: an integrated approach To the practicing endocrinologist. mif-ua.com. Available at: www.mif-ua.com/archive/article/34898. Sözbir, E., & Nazıroğlu, M. (2015). Diabetes enhances oxidative stress-induced TRPM2 channel activity and its control by N-acetylcysteine in rat dorsal root ganglion and brain. Metabolic Brain Disease, 31 (2), 385-393. https://doi.org/10.1007/s11011-015-9769-7 Özcelik, D., Uzun, H., & Nazıroglu, M. (2012). N-Acetylcysteine Attenuates Copper Overload-Induced Oxidative Injury in Brain of Rat. Biological Trace Element Research, 147 (1-3), 292-298. https://doi.org/10.1007/s12011-012-9320-1 Şenol, N., Nazıroğlu, M., & Yürüker, V. (2014). N-Acetylcysteine and Selenium Modulate Oxidative Stress, Antioxidant Vitamin and Cytokine Values in Traumatic Brain Injury-Induced Rats. Neurochemical Research, 39 (4), 685-692. https://doi.org/10.1007/s11064-014-1255-9 ...
This program is about gene technology - the actual techniques used by the scientists producing remarkable breakthroughs in areas like health, agriculture and forensics. The following techniques are covered in depth: polymerase chain reactions; gel electrophoresis; DNA sequencing (in two parts); and genetic modification of organisms. The program focuses on three examples of this technology in action - Menkes disease research (health); transgenic pasture grass research (agriculture); and police forensic work. Footage and expert comment from these working labs along with detailed graphics bring clarity to this difficult subject ...
Our representatives are available to schedule your appointment on weekdays from 8am to 8pm and weekends from 9am to 5pm You may also leave a voicemail message after regular business hours, and we will return your call.. Request an appointment. If this is a medical emergency, please call 9-1-1.. ...
Free Online Library: A Greater Capacity of Metallothionein Synthesis: Would it be Sufficient as Explanation for the Absence of Pathological Effects in Marine Mammals with Extremely High Cd Concentrations? A Review.(Report) by Orbital: The Electronic Journal of Chemistry; Cadmium Distribution Environmental aspects Cadmium compounds Physiological aspects Marine mammals Health aspects Metabolic conjugation Analysis Properties
Posterior cortical atrophy is a clinico-radiological syndrome characterized by progressive decline in visual processing and atrophy of posterior brain regions. With the majority of cases attributable to Alzheimers disease and recent evidence for genetic risk factors specifically related to posterior cortical atrophy, the syndrome can provide important insights into selective vulnerability and phenotypic diversity. The present study describes the first major longitudinal investigation of posterior cortical atrophy disease progression. Three hundred and sixty-one individuals (117 posterior cortical atrophy, 106 typical Alzheimers disease, 138 controls) fulfilling consensus criteria for posterior cortical atrophy-pure and typical Alzheimers disease were recruited from three centres in the UK, Spain and USA. Participants underwent up to six annual assessments involving MRI scans and neuropsychological testing. We constructed longitudinal trajectories of regional brain volumes within posterior ...
Posterior cortical atrophy is a syndromic diagnosis. It is characterised by progressive impairment of higher (cortical) visual function with imaging evidence of degeneration affecting the occipital, parietal and posterior temporal lobes bilaterally. Most caseswill prove to have Alzheimer pathology. The aim of this review is to summarise the development of the concept of this disorder since it was first introduced. A critical discussion of the evolving diagnostic criteria is presented and the differential diagnosis with regard to the underlying pathology is reviewed. Emphasis is given to the visual dysfunction that defines the disorder, and the classical deficits, such as simultanagnosia and visual agnosia, as well as the more recently recognised visual field defects, are reviewed, along with the evidence on their neural correlates. The latest developments on the imaging of PCA are summarised, with special attention to its role on the differential diagnosis with related conditions.
Posterior cortical atrophy (PCA) is a syndromic diagnosis. It is characterized by progressive impairment of higher (cortical) visual function with imaging evidence of degeneration affecting the occipital, parietal, and posterior temporal lobes bilaterally. Most cases will prove to have Alzheimer
Learn more about Posterior Cortical Atrophy causes, sign and symptoms, treatment and diagnosis at FindaTopdoc. Read more information on homeopathic remedies, risks, and prevention.
The Evolution of Alexia in Two Cases of Posterior Cortical Atrophy. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
TY - JOUR. T1 - Looking into posterior cortical atrophy. T2 - Providing insight into Alzheimer disease. AU - Tang-Wai, David F.. AU - Graff-Radford, Neill R.. PY - 2011/5/24. Y1 - 2011/5/24. UR - http://www.scopus.com/inward/record.url?scp=79958134802&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=79958134802&partnerID=8YFLogxK. U2 - 10.1212/WNL.0b013e31821ccd4f. DO - 10.1212/WNL.0b013e31821ccd4f. M3 - Editorial. C2 - 21525423. AN - SCOPUS:79958134802. VL - 76. SP - 1778. EP - 1779. JO - Neurology. JF - Neurology. SN - 0028-3878. IS - 21. ER - ...
The little boy in the picture is my good buddy Logan. He was diagnosed with Leighs disease about two years ago after years of diagnostic testing. Leighs is a Mitochondrial disease. You can read more about Leighs disease here and here. But the short explanation is:Leighs disease, genetic mutations in mitochondrial DNA interfere with the energy sources…
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Clinical Grade Non-Transfusable Mobilized Peripheral Blood CD19 Depleted Cells, G-CSF, Frozen, Human B cells are lymphocytes that are characterized by the expression of CD19 on the cell surface. These cells are one of the main cell types involved in the
TEXTBOOKS. Goodman SI, Frerman FE. Organic acidemias due to defects in lysine oxidation: 2-ketoadipic acidemia and glutaric acidemia. In: Scriver CR, Beaudet AL, Sly WS, et al. Eds. The Metabolic Molecular Basis of Inherited Disease. 7th ed. McGraw-Hill Companies. New York, NY; 1995:1451-60.. JOURNAL ARTICLES. Bahr O, Mader I, Zschocke J, et al. Adult onset glutaric aciduria type I presenting with leukoencephalopathy. Neurology. 2002;59:1802-04.. Kolker S, Ramaekers VT, Zschocke J, et al. Acute encephalopathy despite early therapy in a patient with homozygosity for E365K in the glutaryl-coenzyme A dehydrogenase gene. J Pediatr 2001;138:277-79.. Zafeiriou DI, Zschocke J, Augustidou-Savvopoulou P, et al. Atypical and variable clinical presentation of glutaric aciduria type I. Neuropediatrics. 2000;31:303-06.. Kafil-Hussain NA, Monavari A, Bowell R, et al. Ocular findings in glutaric aciduria type I. J Pediatr Ophthalmol Strabismus. 2000;37:289-93.. Busquets C, Coll MJ, Merinero B, et al. Prenatal ...
OVERVIEW: What every practitioner needs to know Are you sure your patient has glutaric aciduria type I? What are the typical findings for this disease? Glutaric aciduria type I (GA-I) should be considered in any patient who has a history of dystonia/dyskinesia with macrocephaly. Prior to these overt chronic neurologic symptoms, there is usually a…. ...
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However, much later on an infant suffering from glutaric aciduria II will develop macrocephaly. What will trigger the appearance of the symptoms is infection or conditions like gastrointestinal disturbance. The initial results will show symptoms resembling viral encephalitis or ADEM. The patients diagnose with this condition exhibit deterioration of their condition. In some instances, those that exhibit glutaric aciduria II later in their adult life will show encephalopathy and still other symptoms. It is important to have an MRI for proper imaging and to avoid triggering the condition to move from a slower to faster phase and have an effect on the person suffering from this genetic disorder. This inherited genetic disorder leads to an accumulation of glutaric acid in the brain and body fluids. This also includes its presence in the urine. This is an altogether disease different from other unrelated enzyme deficiencies. Even if there are laboratory testing made like routine blood, urine and CSF ...
In Leighs disease, genetic mutations in mitochondrial DNA interfere with the energy sources that run cells in an area of the brain that plays a role in motor movements. The primary function of mitochondria is to convert the energy in glucose and fatty acids into a substance called adenosine triphosphate ( ATP). The energy in ATP drives virtually all of a cells metabolic functions. Genetic mutations in mitochondrial DNA, therefore, result in a chronic lack of energy in these cells, which in turn affects the central nervous system and causes progressive degeneration of motor functions.. There is also a form of Leighs disease (called X-linked Leighs disease) which is the result of mutations in a gene that produces another group of substances that are important for cell metabolism. This gene is only found on the X chromosome. ...
We reviewed the clinical features and etiologies of Leigh disease in 66 patients from 60 pedigrees. Biochemical or molecular defects were identified in 50% of all pedigrees, and in 74% of the 19 pedigrees with pathologically proved Leigh disease. Isolated deficiency of respiratory chain complex I wa …
Emilio Gonzales is a 16 month old baby boy. Hes in has a degenerative neurological condition called Leighs disease. A Google search will reveal that Leighs disease --is a rare inherited neurometabolic disorder characterized by degeneration of the central nervous system. Symptoms of Leighs disease usually begin between the ages of 3 months to 2 years and progress rapidly. In most children, the first signs may be poor sucking ability and loss of head control and motor skills. These symptoms may be accompanied by loss of appetite, vomiting, irritability, continuous crying, and seizures. As the disorder progresses, symptoms may also include generalized weakness, lack of muscle tone, and episodes of lactic acidosis, which can lead to impairment of respiratory and kidney function. Heart problems may also occur.…The most common treatment for Leighs disease is thiamine or Vitamin B1. In patients who have a deficiency of pyruvate dehydrogenase enzyme complex, a high-fat, low-carbohydrate diet ...
2 members Glutaric Aciduria Type 1 is a rare inherited disorder in which the body is unable to break down completely the amino acids lysine, hydroxylysine and tryptophan causing damage to the brain and other... ...
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The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
The most striking feature of the initial clinical presentation was expressive dysphasia. He also initially developed visuoconstructional difficulties, later becoming increasingly ataxic. The imaging is a good demonstration of parietal volume los...
Comparative study of clinical grade human tolerogenic dendritic cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
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Looking for online definition of Glutaric aciduria type 1 in the Medical Dictionary? Glutaric aciduria type 1 explanation free. What is Glutaric aciduria type 1? Meaning of Glutaric aciduria type 1 medical term. What does Glutaric aciduria type 1 mean?
Glutaric acidemia type 1 (or glutaric aciduria, GA1, or GAT1) is an inherited disorder in which the body is unable to completely break down the amino acids lysine, hydroxylysine and tryptophan. Excessive levels of their intermediate breakdown products (glutaric acid, glutaryl-CoA, 3-hydroxyglutaric acid, glutaconic acid) can accumulate and cause damage to the brain (and also other organs), but particularly the basal ganglia, which are regions that help regulate movement. GA1 causes secondary carnitine deficiency, as glutaric acid, like other organic acids, is detoxified by carnitine. Mental retardation may also occur. The severity of glutaric acidemia type 1 varies widely; some individuals are only mildly affected, while others have severe problems. GA1 can be defined as two clinical entities: GA1 before the encephalopathic crisis and GA1 after the encephalopathic crisis. Babies with glutaric acidemia type 1 often are born with unusually large heads (macrocephaly). Macrocephaly is amongst ...
Genetic testing for the GCDH gene, which is associated with glutaric aciduria type I (GA1) and elevated C5-DC on newborn screening (NBS) or acylcarnitine analysis.
Glutaric acid can be prepared by the ring-opening of butyrolactone with potassium cyanide to give the mixed potassium carboxylate-nitrile that is hydrolyzed to the diacid.[1] Alternatively hydrolysis, followed by oxidation of dihydropyran gives glutaric acid. It can also be prepared from reacting 1,3-dibromopropane with sodium or potassium cyanide to obtain the dinitrile, followed by hydrolysis. ...
A linear rate of H2O2 production is found when glutaryl-CoA is incubated with liver homogenates. We term this enzyme activity glutaryl-CoA oxidase. Its main characteristics are described and compared with those of glutaryl-CoA dehydrogenase (EC 1.3.99.7) and palmitoyl-CoA oxidase (EC 1.1.3.-). The latter enzyme catalyses the first step of peroxisomal beta-oxidation. Glutaryl-CoA oxidase shares several properties with palmitoyl-CoA oxidase. The activities of both enzymes in mouse liver are increased by feeding the animals with a clofibrate-containing diet. Subcellular fractionation of the liver homogenates on a linear sucrose gradient indicates that glutaryl-CoA oxidase is a peroxisomal enzyme.. ...
Sorry its been a crazy week, had guests and had showings finally sold our house (building a new one thats almost done) I am doing ok . Yes i have asthma for the person up and my son has some lung stuff going on too. WE have some rare conditions in our family. I have altogether itp, fms, graves, hypoparathyroidism, ibs and a probable neuro muscular disease/metabolic. MY son has glutaric aciduria type 2, and chronic pneumonia and asthma, hypotonia and severe speech delays. my thyroid levels all seem to be in tact, yet, my goiter is still present. I am checked redily on my calcium yet i cant sustain a calcium level of over 6 w/o suppliments. The humidity has brought the worst out in my wheezing. I also noticed blood in urine i have to have checked this week too someitme. I do notice upon excersize sudden race of the heart my o2 drops to lower levels. and I feel it. Is it from being out of shape like my mom says? I find i have a hard time even excersizing but i try to do it safely. Sarah ...
Posterior cortical atrophy (PCA) is a group of neurodegenerative dementing disorders characterized by initial predominant visual complaints followed by progressive decline in cognitive functions. The visuospatial and visuoperceptual defects arise from the dysfunction of, respectively, the dorsal (occipito-parietal) and the ventral (occipito-temporal) streams. Clinical symptoms, results of neuropsychological examination, and findings of posterior cerebral atrophy and/or posterior hypoperfusion/hypometabolism contribute to the diagnosis. However, owing to the insidious onset of PCA and the non-specificity of initial symptoms, the diagnosis is often delayed. Specific etiologies include Alzheimers disease, dementia with Lewy bodies, subcortical gliosis, corticobasal degeneration, and prion-associated diseases. Alzheimers disease accounts for at least 80 % of PCA cases. Recent research has concentrated on better defining the clinical presentation of PCA, improving neuroimaging analysis, t
In the 52 years since the original description of Menkes kinky hair disease (MKHD), advances in understanding the clinical, biochemical, and molecular aspects of this rare disorder of copper metabolism have outstripped progress in the design of effective therapies. The most promising therapy to date, very early subcutaneous copper injections,...
The greatest challenge of majoring in biology in college was mastering the chemical steps that build up and break down the 20 types of amino acids specified by the genetic code. I could memorize ...
The Golm Metabolome Database (GMD) facilitates the search for and dissemination of mass spectra from biologically active metabolites quantified using GC-MS.
(EDIT, May 31, 2014: It has come to my attention that this post is referenced in a book on bioethics. If you have come from that book, remember that (although Ive done my best to be accurate) this is a blog, not a peer-reviewed scientific article. Be sure and read all the comments at the…
If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patients written consent to publication and send them to the editorial office before submitting your response [Patient consent forms] ...
GCDH antibody (glutaryl-CoA dehydrogenase) for ICC/IF, IHC-P, WB. Anti-GCDH pAb (GTX114427) is tested in Human, Mouse samples. 100% Ab-Assurance.
Menkes disease, also known as trichopoliodystrophy or Kinky hair kinky vessel syndrome, is an X-linked recessive disorder that results in a derangement in copper handling. It results in low copper levels and subsequently, deficiency in copper dep...
"Leighs disease" . Genetically modified children: Baby born with DNA from three different people. disease. Preventing genetic diseaseThe fertility procedure was performed on a couple in which the woman was a carrier for a fatal genetic disorder known as Leigh Syndrome. The syndrome is a progressive
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Metabolic Brain Disease. 30 (5): 1279-84. doi:10.1007/s11011-015-9672-2. PMID 25920484.. ... Puck JM, Willard HF (January 1998). "X inactivation in females with X-linked disease". The New England Journal of Medicine. 338 ... An extreme case of this was seen where monozygotic female twins had extreme variance in expression of Menkes disease (an X- ... For example, a female heterozygous for haemophilia (an X-linked disease) would have about half of her liver cells functioning ...
Metabolic Brain Disease. 23 (1): 115-22. doi:10.1007/s11011-007-9076-z. PMID 18034292.. ... "Brain. 128 (7): 1584-94. doi:10.1093/brain/awh496. PMID 15817513.. *^ Kamien, Max (19 June 2006). "The repeating history of ... Metabolic Brain Disease. 14 (1): 1-20. doi:10.1023/A:1020653312697. PMID 10348310.. ... Metabolic Brain Disease. 10 (1): 17-24. doi:10.1007/BF01991779. PMID 7596325.. ...
Metabolic Brain Disease Metab Brain Dis. 30 (5): 1279-284. doi:10.1007/s11011-015-9672-2. CS1 maint: Multiple names: authors ... An extreme case of this was seen where monozygotic female twins had extreme variance in expression of Menkes disease (an X- ... Puck, J; Willard, HF (1998). "X Inactivation in Females with X-Linked Disease". N. Engl. J. Med. 338 (5): 325-8. doi:10.1056/ ... For example, a female heterozygous for haemophilia (an X-linked disease) would have about half of her liver cells functioning ...
Metabolic Brain Disease. 4 (3): 169-76. doi:10.1007/bf01000293. PMID 2796871. Bergeron, M; Swain, MS; Reader, TA; Grondin, L; ... Metabolic Brain Disease. 17 (4): 463-75. doi:10.1023/A:1021986624600. PMID 12602522. Butterworth, RF (2003). "Role of ... severe metabolic alterations and cerebral edema that can lead to brain death. In these cases the mortality without liver ... pathophysiology and treatment of these diseases Evaluate the clinical impact of MARS therapy on the course of the disease in ...
Metabolic Brain Disease. 28 (2): 151-4. doi:10.1007/s11011-012-9337-3. PMID 23010935. S2CID 11206990. Ortez, C; Jou, C; Cortès- ... doi:10.1093/brain/aws038. ISSN 1460-2156. PMC 3326257. PMID 22396397. Hauser, Robert A (July 6, 2016). "Parkinson Disease ... doi:10.1093/brain/aws038. PMC 3326257. PMID 22396397. Kolb, B. Whishaw, I. (2011) An Introduction to Brain and Behavior, 592. ... "Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease". Experimental Neurology. 239: 60-7. ...
Metabolic Brain Disease. 26 (1): 79-85. doi:10.1007/s11011-011-9237-y. PMID 21327546. S2CID 19377135. Robson, D; Welch, E; ... is a disease or category of diseases that commonly causes disability and increases mortality. The causes of TAN are not ... The disease affects poor tropical populations; there are no good statistics on how many people are affected worldwide, but in ... It is possible that there are several diseases being categorized as TAN. It has been estimated that 5% of surviving World War ...
Metabolic Brain Disease. 29 (2): 231-243. doi:10.1007/s11011-013-9457-4. ISSN 0885-7490. PMID 24307180. S2CID 17239167. ... "diseases of the mind." Hippocrates writes: Men ought to know that from the brain, and from the brain only, arise our pleasures ... and Parkinson's disease focal neurological disease, such as stroke, brain tumors, multiple sclerosis, and some forms of ... Mashour GA, Walker EE, Martuza RL (June 2005). "Psychosurgery: past, present, and future". Brain Research. Brain Research ...
Metabolic Brain Disease. 27 (1): 1-5. doi:10.1007/s11011-011-9274-6. PMC 3276770. PMID 22193538. Mashiyama ST, Courtemanche C, ... De Gregori S, De Gregori M, Ranzani GN, Allegri M, Minella C, Regazzi M (2012). "Morphine metabolism, transport and brain ...
Metabolic Brain Disease. 17 (4): 375-387. doi:10.1023/a:1021970120965. ISSN 0885-7490. PMID 12602514. S2CID 23679769. Furrow, S ...
Metabolic Brain Disease. 23 (1): 115-22. doi:10.1007/s11011-007-9076-z. PMID 18034292. S2CID 9020059. Watson, A. J. S.; Walker ... Metabolic Brain Disease. 14 (1): 1-20. doi:10.1023/A:1020653312697. PMID 10348310. S2CID 19954743. Navarro, Darren; Zwingmann, ... Metabolic Brain Disease. 10 (1): 17-24. doi:10.1007/BF01991779. PMID 7596325. S2CID 9751459.. ... Brain atrophy associated with WKS occurs in the following regions of the brain: the mammillary bodies, the thalamus, the ...
Metabolic Brain Disease. 24 (2): 271-82. doi:10.1007/s11011-009-9136-7. PMID 19296210. S2CID 13460935. Galloway GP, Frederick ... It is a precursor to GABA, glutamate, and glycine in certain brain areas. It acts on the GHB receptor and is a weak agonist at ... Both of the metabolic breakdown pathways shown for GHB can run in either direction, depending on the concentrations of the ... GHB-induced stimulation of tissue serotonin turnover may be due to an increase in tryptophan transport to the brain and in its ...
Metabolic Brain Disease. 31 (3): 631-641. doi:10.1007/s11011-016-9794-1. ISSN 0885-7490. PMC 4863909. PMID 26821073. Al Zarouni ... which can cause brain damage, other organ damage, central nervous system damage and death in sheep. Arundo donax, 0.0057% DMT ...
December 2011). "Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse". Metabolic Brain Disease ... Vanier MT, Suzuki K (January 1998). "Recent advances in elucidating Niemann-Pick C disease". Brain Pathology. 8 (1): 163-74. ... Niemann-Pick disease, type C1 (NPC1) is a disease of a membrane protein that mediates intracellular cholesterol trafficking in ... July 1997). "Linkage of Niemann-Pick disease type D to the same region of human chromosome 18 as Niemann-Pick disease type C". ...
Metabolic Brain Disease. 29 (2): 351-7. doi:10.1007/s11011-014-9496-5. PMID 24532047. S2CID 14880172. Roy-Byrne PP, Craske MG, ... Current research also supports this perspective as it has been found that those with panic disorder also have a brain circuit ... "FASTSTATS - Illegal Drug Use". Centers for Disease Control and Prevention. 30 May 2013. Archived from the original on 5 July ... The reason chronic alcohol misuse worsens panic disorder is due to distortion of the brain chemistry and function. ...
Metabolic Brain Disease. 24 (1): 27-53. doi:10.1007/s11011-008-9118-1. PMID 19085093. S2CID 4564675. Sanacora G, Treccani G, ... Centers for Disease Control and Prevention. Archived from the original on 4 February 2016. Retrieved 4 February 2016. ... Winberg S, Carter CG, McCarthy JD, He XY, Nilsson GE, Houlihan DF (1993). "Feeding rank and brain serotonergic activity in ... According to data from the Centers for Disease Control and Prevention, less than one-third of Americans taking one ...
Metabolic Brain Disease. 31 (1): 205-212. doi:10.1007/s11011-015-9681-1. PMID 25987537. S2CID 3234882. Fusco, Carlo; Ucchino, ... Huntington's disease, Wilson disease, hyperthyroidism, lupus erythematosus, pregnancy (chorea gravidarum), drug intoxication ... causing a variety of streptococcal related diseases including Sydenham's chorea but also rheumatic heart disease and nephritic ... biotin-thiamine-responsive basal ganglia disease, Fahr disease, familial dyskinesia-facial myokymia (Bird-Raskind syndrome) due ...
Metabolic Brain Disease. 24 (1): 95-102. doi:10.1007/s11011-008-9112-7. hdl:1866/9593. ISSN 0885-7490. PMID 19104924. Mandiga, ... Sleep inversion is a feature of African trypanosomiasis, after which the disease takes its common name, "African sleeping ... Bosoi, Cristina R.; Rose, Christopher F. (March 2009). "Identifying the direct effects of ammonia on the brain". ... Disease". www.cdc.gov. 2020-04-28. Retrieved 2020-08-11. Maxfield, Luke; Bermudez, Rene (2020), "Trypanosomiasis ( ...
Metabolic Brain Disease. 31 (3): 631-641. doi:10.1007/s11011-016-9794-1. ISSN 0885-7490. PMC 4863909. PMID 26821073. Díaz, J. L ...
Metabolic Brain Disease. 10 (1): 17-24. doi:10.1007/BF01991779. PMID 7596325. Zarranz, Juan J. (2007). Neurologia. (4a ed. ed ... Metabolic Brain Disease. 13 (2): 97-122. doi:10.1023/A:1020657129593. PMID 9699919. James S. Nelson, Hernando Mena & S. ... Martin PR, Singleton CK, Hiller-Sturmhöfel S (2003). "The role of thiamine deficiency in alcoholic brain disease". Alcohol ... Creutzfeldt-Jakob disease, febrile infections this disease may even occur in some people with normal, or even high blood ...
Wu C, Sun D (April 2015). "GABA receptors in brain development, function, and injury". Metabolic Brain Disease. 30 (2): 367-79 ... AMPARs are found in many parts of the brain and are the most commonly found receptor in the nervous system. The AMPA receptor ... Due to their wide distribution within the nervous system of mammals, they play a role in virtually all brain functions. Various ... At membrane potentials more negative than approximately −50 mV, the Mg2+ in the extracellular fluid of the brain virtually ...
Metabolic Brain Disease. 24 (1): 27-53. doi:10.1007/s11011-008-9118-1. PMID 19085093. Sanacora, G; Treccani, G; Popoli, M ( ... At this time, decreased serotonin levels in the brain and symptoms of depression have not been linked Although there is ... Studies also show that the chronic secretion of stress hormones as a result of disease, including somatic infections or ... Murphy, DL; Andrews, AM; Wichems, CH; Li, Q; Tohda, M; Greenberg, B (1998). "Brain serotonin neurotransmission: An overview and ...
Metabolic Brain Disease. 4 (1): 61-65. doi:10.1007/BF00999495. PMID 2704347. Dictionary of Biological Psychology By Philip Winn ... The area postrema also has a significant role in the discussion of Parkinson's disease. Drugs that treat Parkinson's disease ... "Purinergic modulation of area postrema neuronal excitability in rat brain slices". Brain Research. 1165: 50-59. doi:10.1016/j. ... In 1896, he published a two-volume monograph on the gross anatomy of the human brain in which the area postrema was mentioned.[ ...
Metabolic Brain Disease. 22 (3-4): 337-352. doi:10.1007/s11011-007-9064-3. PMID 17712616. S2CID 5823156. Stone TW (April 2001 ... Hypertryptophanemia, is a rare autosomal recessive metabolic disorder that results in a massive buildup of the amino acid ... As the main defect behind hypertryptophanemia is suspected to alter and disrupt the metabolic pathway from tryptophan to ... Stone TW, Mackay GM, Forrest CM, Clark CJ, Darlington LG (July 2003). "Tryptophan metabolites and brain disorders". Clinical ...
Metabolic Brain Disease. 29 (1): 121-30. doi:10.1007/s11011-014-9480-0. PMID 24435938. S2CID 10955351. Piroli GG, Grillo CA, ... Adipose tissue, commonly known as fat, is a depository for energy in order to conserve metabolic homeostasis. As the body takes ... Sonksen P, Sonksen J (July 2000). "Insulin: understanding its action in health and disease". British Journal of Anaesthesia. 85 ... Moreover, impairment in insulin-stimulated trafficking of GLUT4 in the hippocampus result in decreased metabolic activities and ...
Metabolic Brain Disease [serial online]. September 2014;29(3):813-824. Diagram. ... Unilateral asterixis may occur with structural brain disease. It can be a sign of hepatic encephalopathy, damage to brain cells ... With a metabolic encephalopathy, the patient is unable to hold their hands back resulting in a "flapping" motion consistent ... It can also be a feature of Wilson's disease. Asterixis is also seen in respiratory failure due to carbon dioxide toxicity ( ...
Metabolic Brain Disease. 13 (2): 97-122. doi:10.1023/A:1020657129593. PMID 9699919.. ... cancer, AIDS,[41] Creutzfeldt-Jakob disease,[7][42] febrile infections[5]. *this disease may even occur in some people with ... Metabolic Brain Disease. 10 (1): 17-24. doi:10.1007/BF01991779. PMID 7596325.. ... pancreatitis, liver dysfunction, chronic diarrhea, celiac disease, Crohn's disease, uremia,[35] thyrotoxicosis[40] ...
Teune, Laura Klaaske (2013). Glucose metabolic patterns in neurodegenerative brain diseases. PhD Dissertation. Jong, J.T.; J.T ... development of diagnostic tools for Parkinson's disease and more. Much of the data from the LOFAR telescope is stored, accessed ... GLIMPS is a research project set to find faster and more reliable diagnostic tools for Parkinson's disease. GLIMPS explores the ... "Universal risk factors for multifactorial diseases: LifeLines: a three-generation population-based study". European Journal of ...
Metabolic brain disease, 32(1), 195-202. "Anatoly Skalny". publications indexed by Google Scholar. Retrieved December 4, 2020. ... Another area of research is studying the effect of the elements' imbalance on the development of various diseases. Anatoly ... and treatment of many diseases. Anatoly Skalny is an editorial board member in two journals in the field of trace elements ...
"Brain metabolic effects of Neotrofin in patients with Alzheimer's disease". Brain Research. 951 (1): 87-95. doi:10.1016/s0006- ... It stimulates release of nerve growth factors and enhances survival of neurons in the brain, and is under development as a ... Johnston TH, Brotchie JM (July 2004). "Drugs in development for Parkinson's disease". Current Opinion in Investigational Drugs ... potential treatment for neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and stroke. Di Iorio P, ...
Metabolic Brain Disease. 17 (4): 375-87. doi:10.1023/A:1021970120965. PMID 12602514. S2CID 23679769. Cersosimo, M. G.; Koller, ... Takeda, A. (2003). "Manganese action in brain function". Brain Research Reviews. 41 (1): 79-87. doi:10.1016/S0165-0173(02)00234 ... Unlike Parkinson's disease, manganism is not associated with loss of the sense of smell and patients are typically unresponsive ... In the human brain, the manganese is bound to manganese metalloproteins, most notably glutamine synthetase in astrocytes. ...
... crosses the blood-brain-barrier and acts as a TAAR1 agonist,[3] functioning as a selective norepinephrine ... Cody, J. D. (1 December 1993). "Metabolic Precursors to Amphetamine and Methamphetamine". Forensic Science Review. 5 (2): 109- ... a therapeutic strategy for Parkinson's disease?". BioEssays. 26 (1): 80-90. doi:10.1002/bies.10378. PMID 14696044.. ... "Neuroprotection of MAO-B inhibitor and dopamine agonist in Parkinson disease". International Journal of Clinical and ...
... and since brain pathologies such as Alzheimer's disease greatly decrease brain metabolism of both glucose and oxygen in tandem ... Positron-emission tomography (PET)[1] is a nuclear medicine functional imaging technique that is used to observe metabolic ... Khan, FR; Henderson, JM (2013). "Deep Brain Stimulation Surgical Techniques". In Lozano, AM; Hallet, M (eds.). Brain ... and for clinical diagnosis of certain diffuse brain diseases such as those causing various types of dementias. PET is also an ...
These vibrations result in an increase in the metabolic demands of the auditory system. During exposure to sound, metabolic ... any major damage or loss of these hair cells leads to permanent hearing impairment and other hearing-related diseases.[2] Outer ... "Behavioral and Brain Functions. 9 (24). doi:10.1186/1744-9081-9-24. PMC 3685526.. ... The extra demands on the metabolic activity of the system can result in damage that can propagate throughout the ear. ...
mainly in liver, kidneys, brain and muscles. Elimination half-life. ca. 7 days (in hyperthyroidism 3-4 days, in hypothyroidism ... Mandel SJ, Brent GA, Larsen PR (September 1993). "Levothyroxine therapy in patients with thyroid disease". Annals of Internal ... as thyroid hormones may cause an acute adrenal crisis by increasing the metabolic clearance of glucocorticoids.[20] For oral ... For older people (over 50 years old) and people with known or suspected ischemic heart disease, levothyroxine therapy should ...
listen)) is the science and practice of the diagnosis, treatment, and prevention of disease.[4][5] The word "medicine" is ... A main focus of neuroscience is the biology and physiology of the human brain and spinal cord. Some related clinical ... metabolic pathway, blood flow, or other), and a radionuclide (usually either a gamma-emitter or a positron emitter). There is a ... Preventive medicine is the branch of medicine concerned with preventing disease. *Community health or public health is an ...
sulfur compound metabolic process. • metanephric S-shaped body morphogenesis. • metanephros development. • cellular response to ... PAX8 releases the hormones important for regulating growth, brain development, and metabolism. Also functions in very early ... differentiation and disease". Nature Reviews. Endocrinology. 11 (1): 29-42. doi:10.1038/nrendo.2014.186. PMID 25350068.. ... "Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse". The Journal of Clinical ...
Valenstein, Elliot S. (2002). Blaming the Brain : The Truth About Drugs and Mental Health. New York: Free Press. pp. 173-174. ... Chronic illnesses, malnutrition, endocrine, metabolic disorders or chromosomal anomalies are characterized by proportionate ... disease of a major organ system, mistreatment, treatment with certain drugs, chromosomal deletions. Human growth hormone (HGH) ... have worked to medicalize short stature by convincing the public that short stature is a disease rather than a natural ...
Intended for use in the diagnosis of disease or other conditions, or in the cure, mitigation, treatment, or prevention of ... and which does not achieve its principal intended action in or on the human body by pharmacological, immunological or metabolic ... including deep-brain stimulators, can incorporate the ability to transmit vital health information from a patient's body to ... diagnosis, prevention, monitoring, treatment or alleviation of disease,. *diagnosis, monitoring, treatment, alleviation of or ...
"Metabolic syndrome pathophysiology: The role of adiposetissue". Nutrition, Metabolism and Cardiovascular Diseases. 17 (2): 125 ... In the central nervous system, the three outer membranes (the meninges) that envelop the brain and spinal cord are composed of ... Mixed connective tissue disease - a disease of the autoimmune system, also undifferentiated connective tissue disease. ... Congenital diseases include Marfan syndrome and Ehlers-Danlos Syndrome.. *Myxomatous degeneration - a pathological weakening of ...
... and neurofibromatosis type 2 carry a high risk for the development of brain tumors.[21][22] People with celiac disease have a ... Glia come in several types, which perform a number of critical functions, including structural support, metabolic support, ... Secondary brain tumorsEdit. Secondary tumors of the brain are metastatic and have invaded the brain from cancers originating in ... A brain tumor occurs when abnormal cells form within the brain.[2] There are two main types of tumors: malignant or cancerous ...
Paterson, Sue (December 17, 2007). Skin Diseases of Exotic Pets. Blackwell Science, Ltd. pp. 74-79. ISBN 9780470752432. .. ... Reptiles are generally considered less intelligent than mammals and birds.[32] The size of their brain relative to their body ... The allantois (8) is a sac that collects the metabolic waste produced by the embryo. The amniotic sac (10) contains amniotic ... The reptilian nervous system contains the same basic part of the amphibian brain, but the reptile cerebrum and cerebellum are ...
Brain Research. Brain Research Reviews. 37 (1-3): 91-7. doi:10.1016/S0165-0173(01)00126-6. PMID 11744077.. ... Several efficient benzodiazepines offer choices about dosage form, length of action, metabolic interaction and safety. ... "Neuropsychiatric Disease and Treatment. 1 (4): 329-43. PMC 2424120. PMID 18568113.. .mw-parser-output cite.citation{font-style: ... In a rat brain slice preparation, the synthetic steroidal anesthetic alphaxalone (5α-pregnan-3α-ol-11,20 dione) enhanced both ...
"Effect of a 21 day Daniel Fast on metabolic and cardiovascular disease risk factors in men and women" (PDF). Lipids in Health ... During prolonged fasting or very low calorie diets the reduction of blood glucose, the preferred energy source of the brain, ... 2006). "Low-carbohydrate-diet score and the risk of coronary heart disease in women". N. Engl. J. Med. 355 (19): 1991-2002. doi ... Jennifer Petrelli; Kathleen Y. Wolin (2009). Obesity (Biographies of Disease). Westport, Conn: Greenwood. p. 11. ISBN 978-0-313 ...
Heinonen EH, Myllylä V (July 1998). "Safety of selegiline (deprenyl) in the treatment of Parkinson's disease". Drug Saf. 19 (1 ... Moclobemide increases levels of extracellular monoamines and decreases levels of their metabolites in rat brains; tolerance to ... "Moclobemide treatment causes a substantial rise in the sparteine metabolic ratio. Danish University Antidepressant Group". Br ... Reversible MAOIs such as moclobemide may have advantages in the treatment of depression associated with Alzheimer's disease due ...
... main component of amyloid deposits found in AD brains). These mutations result in early-onset Alzheimer's Disease, which is a ... cellular protein metabolic process. • neurogenesis. • intracellular signal transduction. • protein processing. • protein ... Alzheimer's disease[edit]. Alzheimer's disease (AD) patients with an inherited form of the disease may carry mutations in the ... "Entrez Gene: PSEN1 presenilin 1 (Alzheimer disease 3)".. *^ Chan YM, Jan YN (August 1998). "Roles for proteolysis and ...
"Brain-immune interactions and disease susceptibility" (PDF). Molecular Psychiatry. 10: 239-250. doi:10.1038/sj.mp.4001643. ... Interactions between the proinflammatory cytokines and the brain can alter the metabolic activity of neurotransmitters and ... Cortisol is a major stress hormone and has effects on many tissues in the body, including the brain. In the brain, cortisol ... Stress and disease[edit]. The HPA axis is involved in the neurobiology of mood disorders and functional illnesses, including ...
Stargardt's disease. *Uveitis: is a group of 30 intraocular inflammatory diseases[44] caused by infections, systemic diseases, ... Cortical blindness results from injuries to the occipital lobe of the brain that prevent the brain from correctly receiving or ... metabolic disorders, and genetically transmitted syndromes.[29] Cataracts are the leading cause of child and adult blindness ... This is due to the fact the object needs to be approached and carefully felt until a rough idea can be constructed in the brain ...
DNA metabolic process. • telomere organization. • positive regulation of DNA ligation. • cellular response to alkaloid. • ... Liu J, Yuan Y, Huan J, Shen Z (Jan 2001). "Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily ... news from an old disease". Veterinary Pathology. 48 (1): 98-116. doi:10.1177/0300985810390826. PMID 21149845.. ...
Parkinson's Disease and Alzheimer's Disease.[3] There is also an interest in the military potential of biological neurotoxins ... Alkaloids act on diverse metabolic systems in humans and other animals, often with psychotropic or toxic effects. Almost ... As a result, the muscle cells contract permanently, the communication between the brain and the muscles is disrupted and ... "Neurobiology of Disease. 25 (2): 360-366. doi:10.1016/j.nbd.2006.10.002. PMC 3959771. PMID 17098435.. ...
Metabolic Engineering. 49: 153-163. doi:10.1016/j.ymben.2018.08.004. PMID 30107263.. ... higher resistance to pests and diseases, and increased cold-weather tolerance.[109] ... Brain-computer interface. *Electroencephalography. *Mind uploading *Brain-reading. *Neuroinformatics. *Neuroprosthetics *Bionic ...
fatty acid metabolic process. • metabolism. • cardiolipin acyl-chain remodeling. • fatty acid beta-oxidation. ... A compound heterozygous mutation of the HADHB gene can causes axonal Charcot-Marie-tooth disease, which is a neurological ... "Deposition of Alzheimer's vascular amyloid-beta is associated with decreased expression of brain L-3-hydroxyacyl-coenzyme A ... dehydrogenase (ERAB)". Brain Res. 907 (1-2): 44-53. doi:10.1016/S0006-8993(01)02497-0. PMID 11430884.. ...
... excess levels of PAI and alpha 2-antiplasmin have been implicated in the metabolic syndrome and various other disease states. ... experimentally after a stroke to allow blood flow back to the affected part of the brain; and in the event of a massive ... Role in disease[edit]. Few congenital disorders of the fibrinolytic system have been documented. Nevertheless, ... Such results can be seen in peoples with liver disease, PAI-1 deficiency or alpha 2-antiplasmin deficiency. Similar results are ...
The brain type is predominant in adult brain and embryonic tissues, whereas the liver and muscle types are predominant in adult ... Mutations in the liver isoform of glycogen phosphorylase (PYGL) are associated with Hers' Disease (glycogen storage disease ... Moller DE (Dec 2001). "New drug targets for type 2 diabetes and the metabolic syndrome". Nature. 414 (6865): 821-7. doi:10.1038 ... GeneReviews/NCBI/NIH/UW entry on Glycogen Storage Disease Type VI - Hers disease ...
Metabolic functions[edit]. A major function of the peroxisome is the breakdown of very long chain fatty acids through beta ... explaining the disease known as gout, caused by the accumulation of uric acid. Certain enzymes within the peroxisome, by using ... ether phospholipids critical for the normal function of mammalian brains and lungs.[4] They also contain approximately 10% of ... along with a number of metabolic enzymes that were likely recruited from the mitochondria.[21] Recently, it has been suggested ...
F06.9) Unspecified mental disorder due to brain damage and dysfunction and to physical disease *Organic brain syndrome NOS ... Endocrine, nutritional and metabolic diseases V F00-F99 Mental and behavioural disorders ... F62) Enduring personality changes, not attributable to brain damage and disease. *(F63) Habit and impulse disorders *(F63.0) ... F06) Other mental disorders due to brain damage and dysfunction and to physical disease *(F06.0) Organic hallucinosis ...
... reduction in death from coronary heart disease to a point where people are no more likely to die of coronary heart disease than ... Less commonly, arteries of the brain are affected; this may lead to transient ischemic attacks (brief episodes of weakness on ... such as combined hyperlipidemia due to metabolic syndrome.[8] ... The related disease sitosterolemia, which has many similarities ... the underlying cause of cardiovascular disease. The most common problem in FH is the development of coronary artery disease ( ...
... and brain degenerative diseases (Parkinson's disease, dementia, multiple sclerosis, Huntington's disease), among others.[7][76] ... These disorders include certain endocrine diseases (hypo- and hyperthyroidism, hyperprolactinemia),[7][70] metabolic disorders ... celiac disease, non-celiac gluten sensitivity, inflammatory bowel disease),[73][74][75] heart diseases, blood diseases (anemia ... Harris, J. (1998). How the Brain Talks to Itself: A Clinical Primer of Psychotherapeutic Neuroscience. Haworth. p. 284. ISBN ...
"Orphanet Journal of Rare Diseases. 6 (Jun 17): 41. doi:10.1186/1750-1172-6-41. PMC 3143089. PMID 21682876.. ... Brain MRI to rule out any structural abnormalities in the hypothalamus or pituitary and to check for presence of olfactory ... Metabolic. *Amino acid: Ornithine transcarbamylase deficiency. *Oculocerebrorenal syndrome. *Dyslipidemia: Adrenoleukodystrophy ... "Rare Diseases. National Organisation for Rare Disorders (NORD). 2012. Retrieved December 16, 2017.. ...
The adults are larger with different body proportions, less sexual dimorphism, and higher metabolic rates. They mature more ... However, under suitable conditions of drought followed by rapid vegetation growth, serotonin in their brains triggers a ... the linking of human disease outbreaks to locust plagues was widespread. A pestilence in the northwestern provinces of China in ... A Novel Model for Assessing Vertebrate Brain Uptake". Journal of Pharmacology and Experimental Therapeutics. 346 (2): 211-218. ...
Blood-brain barrier. endothelial cells (via passive diffusion/ osmosis & active selection). P-glycoprotein (mechanism by which ... "Pathophysiology: Principles of Disease. Computing Centre, Slovak Academy of Sciences: Academic Electronic Press. Archived from ... As with animals, plants attacked by insects or other pathogens use a set of complex metabolic responses which lead to the ... Main article: Plant disease resistance § Immune system. Members of every class of pathogen that infect humans also infect ...
Instructions for Authors Types of papers Metabolic Brain Disease is committed to high standards of presentation and will ... Metabolic Brain Disease is committed to high standards of presentation and will consider:. Research Papers: No page limitations ... Images such as x rays, laparoscopic images, ultrasound images, brain scans, pathology slides unless there is a concern about ...
... Metabolic Brain Disease serves as a forum for the publication of outstanding basic and ... Metabolic Brain Disease is directed to neuroscientists, psychiatrists, neurologists, pathologists, and others involved in the ... nutritional disorders affecting the brain, diseases affecting neurotransmitters, Alzheimers disease, Parkinsons disease, ... genetic diseases affecting the brain, alcohol and brain metabolism, neuroendocrinopathies, viral and nonviral encephalitides, ...
Metabolic Brain Disease is a quarterly peer-reviewed medical journal covering the study of metabolic brain diseases. It was ... "Metabolic Brain Disease". 2014 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2015. Official website ...
If required by your instructor, you can add annotations to your citations. Just select Add Annotation while finalizing your citation. You can always edit a citation as well. ...
We were able to quantify disease expression at previous time points by projecting onto the PDSP and PDMP. While a univariate ... based on a multivariate classification approach to differentiate between a PD and control group at a late disease stage, where ... analysis indicated metabolic changes which did not persist through time, both PDSP and PDMP were able to differentiate ... investigated the glucose metabolism in an adeno-associated viral vector based alpha-synuclein rat model for Parkinsons disease ...
Interactions among metabolic disease, brain microstructure and cognition. Add to your list(s) Download to your calendar using ... University of Cambridge , Talks.cam , ims-mrl external research seminar , Interactions among metabolic disease, brain ... Institute of Metabolic Science (IMS), Level 4 ATC, Seminar rooms 1-2 . ... Institute of Metabolic Science (IMS), Level 4 ATC, Seminar rooms 1-2 ...
... is drug addiction a brain disease? Answered by Dr. Barbara Lavi: Drug addiction is a: Disease. It changes your brain and leads ... brain disease implies a disorder involving the entire brain in an organic, cellular, or functional way -- not likely to be ... Brain diseases include many different areas and etiologies, but generically this refers to disorders of the brain tissue. They ... Any brain problem is complex because the brain is complex. So yes, drug addiction is a complex brain illness. ...
18F] FDG-PET-based Parkinsons Disease-related Metabolic Brain Pattern (PDRP) As A Progression Biomarker: A 4-year Follow-up In ... FDG-PET brain scan. Previous reports have shown that this pattern is a useful biomarker of disease progression and of ... Background: iRBD is commonly considered to be a prodromal stage of alpha-synucleinopathies such as Parkinsons disease (PD), ... Conclusion:Our preliminary findings show that abnormal metabolic expression begins years before clinical manifestation of ...
Metabolic Brain Disease. Ausgabe 2/2019. Inhaltsverzeichnis ( 29 Artikel ) 14.12.2018 , Review Article , Ausgabe 2/2019 ... Behavioral and electrophysiological brain effects of aspartame on well-nourished and malnourished rats. Paula Catirina Germano ... Serotonin 5-HT1A receptors modulate depression-related symptoms following mild traumatic brain injury in male adult mice. ... Acute stress response to a cognitive task in patients with major depressive disorder: potential metabolic and proinflammatory ...
In the central nervous system, mTOR inhibition demonstrates neuroprotective patterns in aging and Alzheimers disease (AD) by ... for enhancing brain vascular and metabolic functions in rodents at young age (5-6 months of age) and preserving those functions ... for enhancing brain vascular and metabolic functions in rodents at young age (5-6 months of age) and preserving those functions ... However, the effects of mTOR inhibition for in vivo brain physiology remain largely unknown. Here we review recent findings of ...
Findings that piracetam enhances fluidity of brain mitochondrial membranes led to the hypothesis that piracetam might improve ... and reduced sensitivity for apoptosis in a variety of cell and animal models for aging and Alzheimer disease (AD). As a ... and reduced sensitivity for apoptosis in a variety of cell and animal models for aging and Alzheimer disease (AD). As a ... many of the therapeutic effects of piracetam on cognition in aging and dementia as well as different situations of brain ...
All results for evidence-based information from Brain Tumour Charity or British Inherited Metabolic Disease Group for health ... Remove: British Inherited Metabolic Disease Group source - 22 May 2013. - Publisher: British Inherited Metabolic Disease Group ... Remove: British Inherited Metabolic Disease Group source - 22 May 2013. - Publisher: British Inherited Metabolic Disease Group ... Remove: British Inherited Metabolic Disease Group source - 22 March 2012. - Publisher: British Inherited Metabolic Disease ...
Brain Dysfunction in Metabolic Disorders Association for Research in Nervous and Mental Disease Symposia, Volume 53: Brain ... A. N. DAVISON; Association for Research in Nervous and Mental Disease Symposia, Volume 53: Brain Dysfunction in Metabolic ... Association for Research in Nervous and Mental Disease Symposia, Volume 53: ...
Finally, the metabolic change in BA8/9/10 was inversely related to that in BA25 and showed relative increase with cognitive ... The present study is aimed at investigating brain metabolism changes over time, as a potential monitoring marker, in patients ... PET-PAC maps reflecting metabolic per cent annual changes were created for correlation analyses with cognitive decline. In the ... Converters had significantly greater metabolic decrease than non-converters in two ventro-medial prefrontal areas, the ...
Behavioral abnormalities in EOAD are associated with specific dysfunctional changes in brain metabolic activity, in particular ... Consistent with these SSy regional correlations with brain metabolic dysfunction, the connectivity analysis showed increases in ... The aim of this study was to investigate the association between 18 F-FDG-PET regional and connectivity-based brain metabolic ... Voxel-wise correlations between SSy scores and brain glucose metabolism (assessed with 18 F-FDG positron emission tomography) ...
Build: Sat Feb 17 08:59:16 EST 2018 (commit: 16064c5). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
"Brain Diseases, Metabolic" by people in this website by year, and whether "Brain Diseases, Metabolic" was a major or minor ... Acquired Metabolic Diseases, Nervous System*Acquired Metabolic Diseases, Nervous System. *Nervous System Acquired Metabolic ... "Brain Diseases, Metabolic" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Acquired or inborn metabolic diseases that produce brain dysfunction or damage. These include primary (i.e., disorders ...
... with major age-related neurodegenerative diseases and syndromes, including Alzheimers disease, vascular dementia, and mild ... We also provide evidence of PAs role in reducing the risks of these diseases and helping to improve cognitive outcomes in ... A recent alarming rise of neurodegenerative diseases in the developed world is one of the major medical issues affecting older ... by nourishing more brain cells and helping to remove metabolic waste or AD-inducing Aβ. The potential risk-reducing effect of ...
"Brain Tumors." The Online Metabolic and Molecular Bases of Inherited Disease Valle D, Antonarakis S, Ballabio A, Beaudet A, ... Dave Valle, et al.eds. The Online Metabolic and Molecular Bases of Inherited Disease New York, NY: McGraw-Hill; . http://ommbid ... These neoplasms can occur in all areas of the brain and spinal cord in children and adults. Although the vast majority of ... The astrocyte, one form of glial cell that comprises much of the background substance of the brain and spinal cord, is believed ...
Inherited Metabolic Diseases and the Brain R Angus Harkness, J Jaeken, G M Addison, G T N Besley, R J Pollitt ... De som k pt den h r boken har ofta ocks k pt Inherited Metabolic Diseases and the Brain av R Angus Harkness, J Jaeken, G M ... Studies in Inherited Metabolic Disease G M Addison, J M Connor, R Angus Harkness, R J Pollitt H ftad ... Studies in Inherited Metabolic Disease G M Addison, J M Connor, R Angus Harkness, R J Pollitt ...
Alzheimers disease (AD) is a chronic neurodegenerative disorder which can contribute to memory loss and cognitive damage in ... Metabolic Brain Disease. December 2018. , Volume 33, Issue 6, pp 1961-1974 , Cite as ... Peng S, Wuu J, Mufson EJ, Fahnestock M (2010) Precursor form of brain-derived neurotrophic factor and mature brain-derived ... Boeve BF (2012) Mild cognitive impairment associated with underlying Alzheimers disease versus Lewy body disease. Parkinsonism ...
Metabolic Brain Disease Collection: Springer Link 1700 Collection and Nature Journal. Publisher: Springer US ... Experimental Brain Research Collection: Springer Link 1700 Collection and Nature Journal. Publisher: Springer Berlin Heidelberg ...
Brain metabolic signatures across the Alzheimers disease spectrum.. Eur J Nucl Med Mol Imaging. 2020 Feb;47(2):256-269. Epub ... Vasomotion as a Driving Force for Paravascular Clearance in the Awake Mouse Brain.. Neuron. 2020 Feb 5;105(3):549-561.e5. Epub ... A Machine Learning Approach to Identify a Circulating MicroRNA Signature for Alzheimer Disease.. J Appl Lab Med. 2020 Jan 1;5(1 ... Prevalence of cardiovascular drug use before and after diagnosis of Alzheimers disease.. Int J Cardiol. 2020 Feb 1;300:221-225 ...
Brain Diseases, Metabolic, Inborn. Brain Diseases. Lysosomal Storage Diseases. Leukodystrophy, Metachromatic. Metabolic ... Brain Diseases, Metabolic. Nervous System Diseases. Hereditary Central Nervous System Demyelinating Diseases. Lysosomal Storage ... Leukodystrophy, Metachromatic Hereditary Central Nervous System Demyelinating Diseases Brain Diseases, Metabolic, Inborn ... Central Nervous System Diseases. Metabolism, Inborn Errors. Genetic Diseases, Inborn. Sulfatidosis. Leukoencephalopathies. ...
Disease. Pathologic Processes. Brain Diseases. Central Nervous System Diseases. Nervous System Diseases. Tauopathies. ... Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down Syndrome and Dementia. The recruitment status of this study is ... An experimental approach to detecting dementia in Down syndrome: a paradigm for Alzheimers disease. Brain Cogn. 2007 Jun;64(1 ... Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down Syndrome and Dementia. ...
Vijay Varma and colleagues identified metabolites for which brain tissue levels were associated with Alzheimer disease (AD) ... Metabolic pathways Is the Subject Area "Metabolic pathways" applicable to this article? Yes. No. ... Alzheimers disease Is the Subject Area "Alzheimers disease" applicable to this article? Yes. No. ...
Metabolic Brain Disease. 30 (5): 1279-84. doi:10.1007/s11011-015-9672-2. PMID 25920484.. ... Puck JM, Willard HF (January 1998). "X inactivation in females with X-linked disease". The New England Journal of Medicine. 338 ... An extreme case of this was seen where monozygotic female twins had extreme variance in expression of Menkes disease (an X- ... For example, a female heterozygous for haemophilia (an X-linked disease) would have about half of her liver cells functioning ...
Metabolic Brain Disease. 23 (1): 115-22. doi:10.1007/s11011-007-9076-z. PMID 18034292.. ... "Brain. 128 (7): 1584-94. doi:10.1093/brain/awh496. PMID 15817513.. *^ Kamien, Max (19 June 2006). "The repeating history of ... Metabolic Brain Disease. 14 (1): 1-20. doi:10.1023/A:1020653312697. PMID 10348310.. ... Metabolic Brain Disease. 10 (1): 17-24. doi:10.1007/BF01991779. PMID 7596325.. ...
Brain Diseases, Metabolic, Inborn. Brain Diseases, Metabolic. Brain Diseases. Central Nervous System Diseases. Nervous System ... Cerebral Small Vessel Diseases. Cerebrovascular Disorders. Vascular Diseases. Cardiovascular Diseases. Genetic Diseases, X- ... MedlinePlus Genetics related topics: Fabry disease Genetic and Rare Diseases Information Center resources: Fabry Disease ... Genetic Diseases, Inborn. Metabolism, Inborn Errors. Lipidoses. Lipid Metabolism, Inborn Errors. Lysosomal Storage Diseases. ...
Brain Diseases, Metabolic, Inborn. Brain Diseases, Metabolic. Brain Diseases. Central Nervous System Diseases. Nervous System ... Genetic Diseases, Inborn. Glycogen Storage Disease. Lysosomal Storage Diseases. Metabolic Diseases. Metabolism, Inborn Errors. ... Patients with adult onset POMPE disease (onset of symptoms after two years old) and molecular diagnosis confirming the disease ... Genetic and Rare Diseases Information Center resources: Glycogen Storage Disease Type 2 ...
  • Metabolic Brain Disease is directed to neuroscientists, psychiatrists, neurologists, pathologists, and others involved in the research and treatment of a broad range of brain disorders. (springer.com)
  • Brain diseases include many different areas and etiologies, but generically this refers to disorders of the brain tissue. (healthtap.com)
  • These include primary (i.e., disorders intrinsic to the brain) and secondary (i.e., extracranial) metabolic conditions that adversely affect cerebral function. (sickkids.ca)
  • Niemann-Pick disease is a group of severe inherited metabolic disorders, in which sphingomyelin accumulates in lysosomes in cells (the lysosomes normally degrade material that comes from out of cells). (wikipedia.org)
  • These disorders involve the dysfunctional metabolism of sphingolipids, which are fats found in cell membranes (so it is a kind of sphingolipidosis, which is included in the larger family of lysosomal storage diseases). (wikipedia.org)
  • Niemann-Pick diseases are a subgroup of lipid storage disorders called sphingolipidoses in which harmful quantities of fatty substances, or lipids, accumulate in the spleen, liver, lungs, bone marrow, and brain. (wikipedia.org)
  • Genetic brain disorders affect the development and function of the brain. (medlineplus.gov)
  • Some genetic brain disorders are due to random gene mutations or mutations caused by environmental exposure, such as cigarette smoke. (medlineplus.gov)
  • Many people with genetic brain disorders fail to produce enough of certain proteins that influence brain development and function. (medlineplus.gov)
  • These brain disorders can cause serious problems that affect the nervous system. (medlineplus.gov)
  • Experts argue whether Wernicke-Korsakoff syndrome (WKS) is two separate but linked disorders, or if it is a spectrum of a single disease state . (medicalnewstoday.com)
  • This event will discuss the effect of inflammation and metabolic disturbances on mood disorders. (psychu.org)
  • Consistent with its critical role for physiological brain function, disruption of normal glucose metabolism as well as its interdependence with cell death pathways forms the pathophysiological basis for many brain disorders. (nih.gov)
  • Therapy for MOVEMENT DISORDERS, especially PARKINSON DISEASE, that applies electricity via stereotactic implantation of ELECTRODES in specific areas of the BRAIN such as the THALAMUS. (nih.gov)
  • Such strategies have potential not only for the treatment of PD, but perhaps other neurological disorders with a clear pathological pattern of brain activity . (medicalxpress.com)
  • With some of these disorders, if treated early, brain dysfunction can be reversible. (medlineplus.gov)
  • Metabolic disorders may cause confusion and changes in thinking or reasoning. (medlineplus.gov)
  • To rule out certain brain disorders, an EEG (electroencephalogram), head CT scan , or head MRI scan is usually done. (medlineplus.gov)
  • With some metabolic disorders, treatment may stop or even reverse the dementia symptoms. (medlineplus.gov)
  • Medicines used to treat Alzheimer disease have not been shown to work for these types of disorders. (medlineplus.gov)
  • Toxic and Metabolic Disorders. (buecher.de)
  • Experienced clinicians recognize that some children who appear to have static cerebral palsy (CP) actually have underlying genetic-metabolic disorders. (biomedsearch.com)
  • We report a series of patients with motor disorders seen in children with extrapyramidal CP in whom brain magnetic resonance imaging abnormalities provided important diagnostic clues in distinguishing genetic-metabolic disorders from other causes. (biomedsearch.com)
  • Other signal abnormalities and atrophy in the putamen, globus pallidus, or caudate can point to genetic-metabolic diseases, including disorders of mitochondrial and organic acid metabolism. (biomedsearch.com)
  • Progress in understanding and treating genetic diseases of the developing brain makes it essential to diagnose disorders that masquerade as static CP. (biomedsearch.com)
  • The objectives of the present study were to determine the prevalence of developmental defects of the corpus callosum in patients attending a genetics-metabolic disorders clinic, to describe the spectrum of abnormalities in brain development in patients with confirmed inborn errors of metabolism and abnormalities of the corpus callosum as ascertained by neuroimaging and/or postmortem studies. (biomedsearch.com)
  • Naringin is a potential therapeutic agent which could play an important role in the management of metabolic disorders. (greenmedinfo.com)
  • Some of the symptoms that can occur with metabolic disorders are lethargy , weight loss , jaundice and seizures . (wikipedia.org)
  • Inherited metabolic disorders are one cause of metabolic disorders, and occur when a defective gene causes an enzyme deficiency. (wikipedia.org)
  • Metabolic disorders can be present at birth, and many can be identified by routine screening. (wikipedia.org)
  • Specific blood and DNA tests can be done to diagnose genetic metabolic disorders. (wikipedia.org)
  • Metabolic disorders can be treatable by nutrition management, especially if detected early. (wikipedia.org)
  • Age-related neuropsychiatric disorders such as Parkinson disease with and without dementia (PDD and PD, respectively), dementia with Lewy bodies (DLB), amnestic mild cognitive impairment (aMCI), and Alzheimer disease dementia (AD) represent a growing socioeconomic challenge. (snmjournals.org)
  • Although pathophysiologically and clinically different, PD and AD share some aspects in common: both are age-related neurodegenerative disorders characterized by aggregation of pathologic proteins leading to dysfunction of cerebral networks and distinct patterns of metabolic changes ( 3 - 6 ). (snmjournals.org)
  • Researchers in the U.K. are looking to breed marijuana to make medicines for metabolic disorders, epilepsy, and other diseases. (the-scientist.com)
  • In the central nervous system, mTOR inhibition demonstrates neuroprotective patterns in aging and Alzheimer's disease (AD) by preserving mitochondrial function and reducing amyloid beta retention. (frontiersin.org)
  • Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer's disease. (inserm.fr)
  • A sensitive marker for monitoring progression of early Alzheimer's disease would help to develop and test new therapeutic strategies. (inserm.fr)
  • Neuropsychiatric subsyndromes and brain metabolic network dysfunctions in early onset Alzheimer's disease. (escholarship.org)
  • In this review, we provide information about the associations of physical activity (PA) with major age-related neurodegenerative diseases and syndromes, including Alzheimer's disease, vascular dementia, and mild cognitive impairment. (mdpi.com)
  • There are now an estimated 5.4 million Americans (one in nine), aged 65 years and older, with Alzheimer's disease (AD), the most common form of dementia, and this number is expected to almost triple by 2050, as the population ages [ 3 ]. (mdpi.com)
  • Boeve BF (2012) Mild cognitive impairment associated with underlying Alzheimer's disease versus Lewy body disease. (springer.com)
  • Prevalence of cardiovascular drug use before and after diagnosis of Alzheimer's disease. (alzforum.org)
  • β-Amyloid Peptide: the Cell Compartment Multi-faceted Interaction in Alzheimer's Disease. (alzforum.org)
  • Role for ATXN1, ATXN2, and HTT intermediate repeats in frontotemporal dementia and Alzheimer's disease. (alzforum.org)
  • Brain metabolic signatures across the Alzheimer's disease spectrum. (alzforum.org)
  • Is the Subject Area "Alzheimer's disease" applicable to this article? (plos.org)
  • Alzheimer's disease (AD) is the most common dementia, and the development of drug therapies for AD has advanced in recent years. (jneuropsychiatry.org)
  • Cortical metabolism declines as Alzheimer's disease progresses [ 10 - 13 ]. (jneuropsychiatry.org)
  • Alzheimer's disease (AD) is a progressive disorder associated with disruption of neuronal function and neuronal loss. (elsevier.com)
  • TgF344-AD is a transgenic rat model of Alzheimer's disease (AD) that shows all its pathological hallmarks in a progressive way. (ismrm.org)
  • On the research front, he leads the MAC PET imaging program , is principal investigator of a cohort study of early-onset Alzheimer's disease and of Imaging Dementia: Evidence for Amyloid Scanning (IDEAS), a U.S.-wide study sponsored by the Centers for Medicare and Medicaid Services to assess the clinical utility of amyloid PET in 18,500 Medicare beneficiaries. (ucsf.edu)
  • Awards recognizing his work include the 2015 Christopher Clark Award for Advancement of the Field of Amyloid Imaging, the 2012 American Academy of Neurology Research Award in Geriatric Neurology and the 2010 Best Paper in Alzheimer's Disease Neuroimaging: New Investigator Award from the Alzheimer's Association. (ucsf.edu)
  • Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease. (ucsf.edu)
  • Alzheimer's disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation. (ucsf.edu)
  • Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain. (ucsf.edu)
  • A research team at the University of Miami Miller School of Medicine's Center for Therapeutic Innovation ( CTI ) has identified a novel epigenetic drug target to simultaneously normalize multiple deficits in Alzheimer's disease (AD), the most common form of dementia in the elderly and the sixth leading cause of death in the U.S., according to the Alzheimer's Association. (healthcanal.com)
  • The researchers demonstrated that epigenetic "eraser" enzyme, histone deacetylase 3 (HDAC3) is connected to multiple Alzheimer's disease hallmarks, including beta-amyloid (Aβ), hyperphosphorylated tau and several other aberrant genes. (healthcanal.com)
  • His laboratory conducted the new study, which was supported by the National Institutes of Health and the State of Florida Department of Health (the Ed and Ethel Moore Alzheimer's Disease Research Program). (healthcanal.com)
  • We were able to demonstrate that it is possible to re-program neuronal cell gene expression and thereby achieve a very striking reversal of deteriorating memory in our Alzheimer's disease model. (healthcanal.com)
  • Efficacy was investigated by the change of the scores of Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-Cog), Activities of Daily Life (ADL) and Unified Parkinson's Disease Rating Scale (UPDRS) part III (motor scale). (scirp.org)
  • Despite decades of research devoted to understanding its origins, Alzheimer's disease remains a daunting and devastating neurological mystery, ranking as the sixth leading killer of Americans. (plos.org)
  • LA JOLLA, CALIF. - Nov. 21, 2018 - Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified gene recombination in neurons that produces thousands of new gene variants within Alzheimer's disease brains. (eurekalert.org)
  • Using new analytical methods focused on single and multiple-cell samples, the researchers found that the APP gene, which produces the toxic beta amyloid proteins defining Alzheimer's disease, gives rise to novel gene variants in neurons--creating a genomic mosaic. (eurekalert.org)
  • Gene recombination was discovered as both a normal process for the brain and one that goes wrong in Alzheimer's disease. (eurekalert.org)
  • One hundred percent of the Alzheimer's disease brain samples contained an over-abundance of distinct APP gene variants, compared to samples from normal brains. (eurekalert.org)
  • Among these Alzheimer's-enriched variations, the scientists identified 11 single-nucleotide changes identical to known mutations in familial Alzheimer's disease--a very rare inherited form of the disorder. (eurekalert.org)
  • Although found in a mosaic pattern, the identical APP variants were observed in the most common form of Alzheimer's disease, further linking gene recombination in neurons to disease. (eurekalert.org)
  • These findings may fundamentally change how we understand the brain and Alzheimer's disease," says Chun. (eurekalert.org)
  • The secret code is being used in healthy brains but also appears to be disrupted in Alzheimer's disease. (eurekalert.org)
  • Although there is no medical evidence that HIV or AIDS causes Alzheimer's disease, existing FDA-approved antiretroviral therapies for HIV that block reverse transcriptase might also be able to halt the recombination process and could be explored as a new treatment for Alzheimer's disease. (eurekalert.org)
  • The scientists noted the relative absence of proven Alzheimer's disease in aging HIV patients on antiretroviral medication, supporting this possibility. (eurekalert.org)
  • Our findings provide a scientific rationale for immediate clinical evaluation of HIV antiretroviral therapies in people with Alzheimer's disease," says Chun. (eurekalert.org)
  • Such studies may also be valuable for high-risk populations, such as people with rare genetic forms of Alzheimer's disease. (eurekalert.org)
  • This helps explain why copies of the APP gene are not accurate in Alzheimer's disease and how the diversity of DNA in the neurons is created. (eurekalert.org)
  • The amyloid hypothesis, or the theory that accumulation of a protein called beta-amyloid in the brain causes Alzheimer's disease, has driven Alzheimer's research to date. (eurekalert.org)
  • The thousands of APP gene variations in Alzheimer's disease provide a possible explanation for the failures of more than 400 clinical trials targeting single forms of beta-amyloid or involved enzymes," says Chun. (eurekalert.org)
  • APP gene recombination in Alzheimer's disease may be producing many other genotoxic changes as well as disease-related proteins that were therapeutically missed in prior clinical trials. (eurekalert.org)
  • The researchers believe that berberine is a promising drug candidate against Alzheimer's disease. (naturalnews.com)
  • Alzheimer's disease is a progressive degenerative disease that affects the central nervous system. (naturalnews.com)
  • According to the researchers, therapeutic strategies that were based on decreasing the amount of B -amyloid in the brain have failed in clinical trials, suggesting that Alzheimer's disease therapy should not be focused on addressing a single cause, but rather a number of different pathways that lead to the disease. (naturalnews.com)
  • BOSTON - (February 11, 2019) -- Scientists continue to find evidence linking Type 2 diabetes with Alzheimer's disease, the most common form of dementia and the seventh leading cause of death in the. (joslin.org)
  • 2019). "Sodium and water handling during hemodialysis: new pathophysiologic insights and management approaches for improving outcomes in end-stage kidney disease. (nottingham.ac.uk)
  • 2019). Lipid metabolic pathways converge in motor neuron degenerative diseases. (news-medical.net)
  • CHICAGO - Aug. 26, 2019 - PRLog -- An estimated 250,000 people in the United States have dystonia, a chronic movement disorder affecting the brain and nervous system. (prlog.org)
  • BOSTON -- (May 6, 2019) -- Many in-development cures for type 1 diabetes have understandably focused on tackling the autoimmune aspect of the disease before figuring out a way to replace the destroyed. (joslin.org)
  • This is a naturalistic study in which clinical evaluations and brain scans will be performed on 72 people with Down syndrome (DS), 36 non-demented and 36 with dementia, as well as 36 age-matched healthy controls. (clinicaltrials.gov)
  • Is Metabolic Syndrome dumbing down the teenage brain? (pritikin.com)
  • Yes, suggests new research, which found lower reading and math scores and other measures of cognitive ability among U.S. teens with the Metabolic Syndrome. (pritikin.com)
  • What is the Metabolic Syndrome, and what can we do about it? (pritikin.com)
  • A new study published in the medical journal Pediatrics found that overweight or obese teens with the Metabolic Syndrome "showed significantly lower arithmetic, spelling, attention, and mental flexibility and a trend for lower overall intelligence, " reported the New York University School of Medicine authors. (pritikin.com)
  • What is the Metabolic Syndrome? (pritikin.com)
  • The Metabolic Syndrome is a cluster of factors indicating a dysfunctional metabolism. (pritikin.com)
  • Government health surveys estimate that nearly 1 in 10 U.S. teens - and more than one-third of overweight and obese teens - have the Metabolic Syndrome. (pritikin.com)
  • For years, scientists have known that the Metabolic Syndrome can greatly increase the risk of diabetes and heart attacks. (pritikin.com)
  • But they assumed that the brain dysfunction seen in adults had happened after many years, maybe even decades, of living with the syndrome. (pritikin.com)
  • It suggests that if you have the Metabolic Syndrome in your adolescent years, you may be suffering some of its damaging effects - in your adolescent years. (pritikin.com)
  • Shockingly, the NYU scientists also found that the syndrome affected the physical nature of the brain. (pritikin.com)
  • They took MRIs of 49 teens with the Metabolic Syndrome as well as MRIs of 62 other teens who were syndrome-free, and discovered that the youth with the syndrome had "smaller hippocampal volumes" (the hippocampus plays a major role in the learning and recall of new information), as well as other brain changes, including "reductions of microstructural integrity in major white matter tracts. (pritikin.com)
  • And the more Metabolic Syndrome factors the teenagers had, the greater the brain impairments were. (pritikin.com)
  • In all three studies, tracking overweight children ages 8 to 17 who arrived at Pritikin with the Metabolic Syndrome, the scientists found that 100% of the children were able to reduce several metabolic risk factors, including triglycerides, blood pressure, and blood sugar. (pritikin.com)
  • And 100% of the children returned home no longer classified as having the Metabolic Syndrome. (pritikin.com)
  • It is poor food and fitness that cause the Metabolic Syndrome. (pritikin.com)
  • Not so with the Metabolic Syndrome. (pritikin.com)
  • Intrinsic brain abnormalities in irritable bowel syndrome and effect of anxiety and depression. (rochester.edu)
  • Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial. (ucsf.edu)
  • Metabolic syndrome increases the risk for development of heart disease. (bioportfolio.com)
  • Another condition associated with metabolic syndrome is fatty liver disease which is also referred to as nonalcoholic fatty liver disease (NAFLD). (bioportfolio.com)
  • The present study will test the drug 3-V Bioscience-2640 in healthy subjects with characteristics of the metabolic syndrome before and after 10 days of treatment to determine if 200 mg/d significantly reduces liver fat synthesis and lowers liver fat storage. (bioportfolio.com)
  • Here, the subjects will be men with characteristics of the metabolic syndrome, who are otherwise healthy. (bioportfolio.com)
  • The focus on subjects with metabolic syndrome is based on the fact that the future use of the drug will be in patients with NAFLD who will likely have metabolic syndrome characteristics. (bioportfolio.com)
  • 14 A 2014 study in Surgical Neurology International coined a term for this increasingly prevalent problem: "diminished brain resilience (DBR) syndrome. (westonaprice.org)
  • Not to be confused with Metabolic syndrome or Diabetes . (wikipedia.org)
  • Subscribe to the world's most popular newsletters for Fibromyalgia, ME/CFS (Chronic Fatigue Syndrome) and Lyme Disease. (prohealth.com)
  • Its proponents posit that mitochondrial dysfunction lies at the heart of neural degeneration, driven by metabolic abnormalities which lead to classic Alzheimer's pathology. (plos.org)
  • We discuss here potential mechanisms by which metabolic defects affect diverse biochemical pathways, altering key neurobiological processes (e.g. defective cell membrane formation, cellular bioenergetics and cell-to-cell signaling), that eventually lead to structural abnormalities in the developing nervous system. (biomedsearch.com)
  • Defect in gene transcription, excitotoxicity, neuroinflammation and oxidative stress are the dominant disease process that causes striatal cell loss with motor abnormalities in Huntington's disease (HD). (springer.com)
  • Brain ischemia has been linked to a variety of diseases or abnormalities. (wikipedia.org)
  • We investigated the glucose metabolism in an adeno-associated viral vector based alpha-synuclein rat model for Parkinson's disease (PD) using longitudinal 18 F-FDG PET imaging, which resulted in an improved characterization of this animal model. (nature.com)
  • The characteristic brain pathology in PD results in a pattern of abnormal cerebral glucose metabolism known as the PD-related pattern (PDRP). (rug.nl)
  • The present study is aimed at investigating brain metabolism changes over time, as a potential monitoring marker, in patients with amnestic mild cognitive impairment, according to their clinical outcome (converters or non-converters), and in relation to their cognitive decline. (inserm.fr)
  • Therewere inconsistencies between the regions with increased metabolic activity and perfusionafter memantine treatment in drug-naïve AD patients, suggesting that brain metabolism mayincrease without a concurrent increase in blood perfusion. (jneuropsychiatry.org)
  • The mammalian brain depends upon glucose as its main source of energy, and tight regulation of glucose metabolism is critical for brain physiology. (nih.gov)
  • Here, we review recent advances in understanding how glucose metabolism sustains basic brain physiology. (nih.gov)
  • Glucose (Glc) is the main source of energy for the mammalian brain, (a) Specialized centers in the brain, including proopiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons in the hypothalamus, sense central and peripheral glucose levels and regulate glucose metabolism through the vagal nerve as well as neuroendocrine signals. (nih.gov)
  • (b) Glucose supply to the brain is regulated by neurovascular coupling and may be modulated by metabolism-dependent and -independent mechanisms. (nih.gov)
  • those whose mother (but not father) had the disease also show reduced glucose metabolism and cognitive function , as well as elevated PIB uptake (a marker of amyloid) and brain atrophy . (plos.org)
  • A new study published in the journal Brain: a Journal of Neurology suggests a novel hypothesis as to how motor neuron disease (MND) develops as a result of abnormal cholesterol metabolism within nerve cells. (news-medical.net)
  • Belenky P, Bogan KL, Brenner C (2007) NAD+ metabolism in health and disease. (springer.com)
  • [6] These diseases, of which there are many subtypes, are known as inborn errors of metabolism . (wikipedia.org)
  • The recent discovery of mutations affecting metabolic enzymes such as succinate dehydrogenase, fumarate hydratase and isocitrate dehydrogenase provides genetic evidence that altered cellular metabolism can cause cancer. (keystonesymposia.org)
  • Ischemia leads to alterations in brain metabolism, reduction in metabolic rates, and energy crisis. (wikipedia.org)
  • Brain cells are particularly sensitive to low levels of thiamine because it is required in many cellular pathways needed for normal brain activity. (medicalnewstoday.com)
  • The brain regulates the gut and its microbiota via neuroanatomic, immunological, and neuroendocrine-HPA axis pathways, communicating via neurotransmitters, neuropeptides, or microbial-derived products effecting gut microbiota. (springermedizin.de)
  • Researchers unveil the most comprehensive atlas of genes underlying human metabolic pathways, paving the way for improved understanding and treatment of metabolic diseases. (the-scientist.com)
  • Metabolic Brain Disease serves as a forum for the publication of outstanding basic and clinical papers on brain diseases, including both human and animal studies. (springer.com)
  • Conclusion:Our preliminary findings show that abnormal metabolic expression begins years before clinical manifestation of parkinsonian symptoms in iRBD patients, and that changes in PDRP expression over time may provide a useful metric for predicting phenoconversion to alpha-synucleinopathy diseases. (rug.nl)
  • This Physician Initiated Request program allows physicians to request permission from Amicus to receive migalastat HCl for specific patients with Fabry disease who have a mutation amenable to this treatment, who do not have access to available treatment alternatives, or do not meet requirements for participation in an existing migalastat clinical study. (clinicaltrials.gov)
  • This project is an observational prospective study in which patients affected by an adult onset Pompe disease will be followed-up during three years using different clinical, analytical and radiological tests in order to know which is the natural history of the disease and which is the impact that treatment with recombinant enzyme has in the progression of the disease. (clinicaltrials.gov)
  • The results were published in the Journal of Clinical Endocrinology and Metabolis by Dr. Johnny Deladoëy, a pediatric endocrinologist and researcher in metabolic and genetic diseases at CHU Sainte-Justine Research Center and an assistant professor of pediatrics and biochemistry at University of Montreal. (healthcanal.com)
  • Considering that the majority of clinical trials focused on traditional AD targets have failed to date, our group focused on the multifactorial aspect of the disease, and we hope our recent discovery will guide the development of AD therapeutics. (healthcanal.com)
  • The results provided new insight into brain activity underlying PD pathology and suggested that clinical improvement was achieved by disruption of a particular pattern from the variety of abnormal activity seen in the Parkinsonian brain. (medicalxpress.com)
  • Jankovic, J. (2008) Parkinson's Disease: Clinical Features and Diagnosis. (scirp.org)
  • Our aim was to evaluate whether brain development in late pregnancy can be predicted by fetal brain Doppler, head biometry and the clinical form of CHD at the time of diagnosis. (nih.gov)
  • Thus, the new study could help to improve diagnosis and predict the clinical course of the disease, including the severity of the final stages. (news-medical.net)
  • It will focus on obtaining insights into the interrelated problems of developmental and molecular biology and clinical diseases by i. generating MR probes that function as real-time in vivo physiological reporters (exogenous), ii. (chicagobiomedicalconsortium.org)
  • These metabolic models will be combined with enhanced MR imaging applicable to clinical field strengths of 3.0 Telsa. (chicagobiomedicalconsortium.org)
  • Good clinical outcome achieved when hematopoietic stem cell transplantation performed at the very early stage of the disease. (sigmaaldrich.com)
  • The clinical course may be similar to LEIGH DISEASE. (harvard.edu)
  • Parkinson disease with and without dementia (PDD and PD, respectively), dementia with Lewy bodies (DLB), and Alzheimer dementia (AD) traditionally have been viewed as distinct clinical and pathologic entities. (snmjournals.org)
  • Indeed, the notion that PD and AD may be extremes of a spectrum of neurodegenerative diseases-with DLB and PDD presenting overlapping neuropathologic and clinical features within this spectrum-has received growing attention in recent years ( 4 ). (snmjournals.org)
  • Because the pattern of histopathology, neuronal network dysfunction, and associated clinical deficits is indeed continuous, the traditional view of distinct disease entities is increasingly being questioned. (snmjournals.org)
  • Acquired or inborn metabolic diseases that produce brain dysfunction or damage. (sickkids.ca)
  • In 2001, I joined the faculty of the Department of Biophysics at MCW, where I continue my work on redox mechanisms of cardiovascular and fetal brain dysfunction. (mcw.edu)
  • These, in conjunction with an underlying deficiency in long chain PUFA, may damage the arcuate nucleus as well as neuropeptide-Y and pro-opiomelanocortin neurons and insulin receptors in the brain, especially during fetal life, infancy, and childhood, resulting in their dysfunction(32). (blogspot.com)
  • So if mitochondrial dysfunction initiates the Alzheimer's cascade, what are the steps leading from metabolic disruption to neurodegeneration and ultimately, dementia? (plos.org)
  • Cattaneo E (2003) Dysfunction of wild type huntingtin in Huntington disease. (springer.com)
  • Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that typically occurs in elderly people and affects about one percent of persons older than 60 years 1 . (nature.com)
  • brain disease' implies a disorder involving the entire brain in an organic, cellular, or functional way -- not likely to be treated by surgery alone. (healthtap.com)
  • A genetic brain disorder is caused by a variation or a mutation in a gene. (medlineplus.gov)
  • A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. (nih.gov)
  • Inflammatory bowel disease (IBD) is a gut disorder which is characterized by a recurrent and chronic gastrointestinal inflammation. (springermedizin.de)
  • Bilney B, Morris ME, Churchyard A, Chiu E, Georgiou-Karistianis N (2005) Evidence for a disorder of locomotor timing in Huntington's disease. (springer.com)
  • A metabolic disorder can happen when abnormal chemical reactions in the body alter the normal metabolic process . (wikipedia.org)
  • The symptoms expressed would vary with the type of metabolic disorder. (wikipedia.org)
  • If a metabolic disorder is not identified early, then it may be diagnosed later in life, when symptoms appear. (wikipedia.org)
  • In terms of pathophysiological/mechanism interactions, an abnormal gut microbioma can play a role in metabolic disorder related obesity. (wikipedia.org)
  • It is the third most common movement disorder after essential tremor and Parkinson disease. (prlog.org)
  • An autosomal recessive metabolic disorder caused by absent or decreased PYRUVATE CARBOXYLASE activity, the enzyme that regulates gluconeogenesis, lipogenesis, and neurotransmitter synthesis. (harvard.edu)
  • Background: iRBD is commonly considered to be a prodromal stage of alpha-synucleinopathies such as Parkinson's disease (PD), Dementia with Lewy Bodies (DLB), or Multiple System Atrophy (MSA). (rug.nl)
  • Neuroprotective effect of crocin against rotenone-induced Parkinson's disease in rats: Interplay between PI3K/Akt/mTOR signaling pathway and enhanced expression of miRNA-7 and miRNA-221. (alzforum.org)
  • Parkinson's disease (PD) is a devastating and incurable disease that causes abnormal poverty of movement, involuntary tremor, and lack of coordination. (medicalxpress.com)
  • Many patients with Parkinson's disease suffer cognitive impairment or dementia. (scirp.org)
  • Cholinesterase inhibitors (ChEIs) have positive effects on patients with Parkinson's Disease Dementia (PDD). (scirp.org)
  • Aarsland, D., Zaccai, J. and Brayne, C. (2005) A Systematic Review of Prevalence Studies of Dementia in Parkinson's Disease. (scirp.org)
  • Fletcher, P., Leake, A. and Marion, M.H. (2011) Patients with Parkinson's Disease Dementia Stay in the Hospital Twice as Long as Those without Dementia. (scirp.org)
  • Bedard C, Wallman MJ, Pourcher E, Gould PV, Parent A, Parent M (2011) Serotonin and dopamine striatal innervation in Parkinson's disease and Huntington's chorea. (springer.com)
  • Alzheimer's pathology targets distinct memory networks in the ageing brain. (ucsf.edu)
  • citation needed] Niemann-Pick disease is inherited in an autosomal recessive pattern, which means both copies, or both alleles of the gene, must be defective to cause the disease. (wikipedia.org)
  • We generated a PD specific pattern (PDSP) based on a multivariate classification approach to differentiate between a PD and control group at a late disease stage, where the neurodegeneration is considered nearly complete. (nature.com)
  • In the central nervous system, mTOR inhibition has been shown to prevent neurodegeneration and protect brain functions in aging. (frontiersin.org)
  • As a specific feature of piracetam and other similar compounds, beneficial effects on cognition are usually associated with impaired brain function such as aging, hypoxia, glucose deprivation, injuries, or even neurodegeneration. (frontiersin.org)
  • Huntington's disease HD is caused by an expansion of the trinucleotide poly CAG tract located in exon 1 of the huntingtin Htt gene leading to progressive neurodegeneration in selected brain regions, and associated functional impairments in motor, cognitive, and psychiatric domains. (duhnnae.com)
  • Researchers have discovered that impairing a critical partnership between brain cells can lead to neurodegeneration. (medicalxpress.com)
  • The metabolic imaging analysis supports the notion that there is a continuous spectrum of neurodegeneration between AD and PD. (snmjournals.org)
  • Mahmoodabadi SZ, Alirezaie J, Babyn P, Kassner A, Widjaja E. Wavelets and fuzzy relational classifiers: a novel diffusion-weighted image analysis system for pediatric metabolic brain diseases. (sickkids.ca)
  • and guidance on limiting the use of ionizing radiation in evaluating pediatric diseases. (elsevier.com)
  • Research in pediatric thyroid diseases at CHU Sainte-Justine is supported by the Girafonds/CHU Sainte-Justine Foundation. (healthcanal.com)
  • Consideration of Sex Differences in the Measurement and Interpretation of Alzheimer Disease-Related Biofluid-Based Biomarkers. (alzforum.org)
  • The principal objective of the study is to find biomarkers that quantify the natural progression of the disease and to know if they are useful to determine the improvement or lack of impairment of the disease in response to Enzyme Replacement Therapy (ERT). (clinicaltrials.gov)
  • Findings that piracetam enhances fluidity of brain mitochondrial membranes led to the hypothesis that piracetam might improve mitochondrial function, e.g., might enhance ATP synthesis. (frontiersin.org)
  • This assumption has recently been supported by a number of observations showing enhanced mitochondrial membrane potential, enhanced ATP production, and reduced sensitivity for apoptosis in a variety of cell and animal models for aging and Alzheimer disease. (frontiersin.org)
  • The Mitochondrial Hypothesis: Is Alzheimer's a Metabolic Disease? (plos.org)
  • For the mitochondrial theory to hold water, it must critically account for the classic pathological markers that define Alzheimer's and have shaped traditional disease models - namely, amyloid plaques, tau tangles and brain atrophy. (plos.org)
  • Increasing levels of such stress and the switch to immune and metabolic downregulation are detailed next in relation to the advent of hypernitrosylation, impaired mitochondrial performance, immune suppression, cellular hibernation, endotoxin tolerance and sirtuin 1 activation. (prohealth.com)
  • Toxic metabolic encephalopathies (TMEs) present as an acute derangement in consciousness, cognition and behavior, and can be brought about by various triggers, including endocrine and metabolic disturbances, exogenous toxins, pain and infection. (nih.gov)
  • Andreassen OA, Dedeoglu A, Stanojevic V, Hughes DB, Browne SE, Leech CA, Ferrante RJ, Habener JF, Beal MF, Thomas MK (2002) Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression. (springer.com)
  • Darocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, Rodríguez M, Sánchez B, Hyman BT, Gómez-Isla T (2011) Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice. (springer.com)
  • The purpose of this study is to develop small molecule radio-labeled probes of beta-amyloid, to be used with positron emission tomography (PET) for early detection and treatment monitoring of Alzheimer disease (AD). (clinicaltrials.gov)
  • A common thread across many of these drugs is their targeting the defining marker of the disease, amyloid plaques - those nasty extracellular deposits of beta-amyloid protein that invariably present in the Alzheimer's brain and are thought to be toxic to neurons. (plos.org)
  • We used new approaches to study the APP gene, which gives rise to amyloid plaques, a pathological hallmark of the disease," says Jerold Chun, M.D., Ph.D. , senior author of the paper and professor and senior vice president of Neuroscience Drug Discovery at SBP. (eurekalert.org)
  • One of the most widely accepted is the amyloid- B protein cascade hypothesis, which states that the accumulation of amyloid- B peptides in the brain is the primary cause of Alzheimer's. (naturalnews.com)
  • Methods: In our first study ("REMPET1"), 21 iRBD patients without parkinsonism or dementia, 19 controls, 20 PD patients, and 22 DLB patients underwent static [18F]FDG-PET brain imaging. (rug.nl)
  • Patients with glycogen storage disease type III may become hypoglycaemic during a fast, the length of which varies widely between patients. (evidence.nhs.uk)
  • Glioblastoma multiforme, the most common malignant primary brain tumor of adults, is characterized by gains of chromosome 7 and losses of chromosome 10, which are seen in up to 80 to 90 percent of patients. (mhmedical.com)
  • This program allows physicians to request permission from Amicus Therapeutics (Amicus) for treatment access to migalastat hydrochloride (HCl) for specific adult patients with Fabry disease. (clinicaltrials.gov)
  • We believe this is the first stu dy focusing on brain metabolic activity and perfusioni n the same drug-naïve moderate AD patients before and after memantine treatment. (jneuropsychiatry.org)
  • Many previous studies have measured perfusion and metabolic activity in AD patients treated with ChEIs. (jneuropsychiatry.org)
  • Re-Establishing Brain Networks in Patients with ESRD after Successful Kidney Transplantation. (rochester.edu)
  • Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy. (ucsf.edu)
  • A technique called deep brain stimulation (DBS) is sometimes used to improve motor symptoms in patients with advanced disease. (medicalxpress.com)
  • Nineteen patients (10 males, 9 females) with confirmed metabolic diagnoses were identified by systematic search of the genetics clinic database. (biomedsearch.com)
  • Following this concept, we built a topological map based on regional patterns of the cerebral metabolic rate of glucose as measured with 18 F-FDG PET to rank and localize single subjects' disease status according to PD-typical (PD vs. controls) and AD-typical (AD vs. controls) pattern expression in patients clinically characterized as PD, PDD, DLB, amnestic mild cognitive impairment, and AD. (snmjournals.org)
  • For the health and safety of our patients, visitors, and staff we are following recommendations of the Massachusetts Department of Public Health and the Centers for Disease Control . (joslin.org)
  • Hepatic encephalopathy is probably not truly a degenerative brain disease, but it certainly causes confusion. (healthtap.com)
  • Any metabolic stress can lead to serious illness, with encephalopathy - a reduced level. (evidence.nhs.uk)
  • Wernicke's encephalopathy may be underdiagnosed because symptoms vary between people depending on the area of the brain most affected. (medicalnewstoday.com)
  • She is now applying these developments on chronic hepatic encephalopathy, a research area that she developed at CIBM ( https://actu.epfl.ch/news/when-liver-disease-affects-the-brain/ ), and on different collaborative projects with researchers from the five partner institutions of CIBM. (epfl.ch)
  • Background and Objective: Previous studies revealed the association between serum Nterminal pro-brain natriuretic peptide (NT-proBNP) level and chronic kidney diseases (CKD) in general population. (eurekaselect.com)
  • Parents of children with chronic diseases often report increased level of stress and anxiety. (bioportfolio.com)
  • Find out why we're experts in chronic disease. (prohealth.com)
  • The aim of this study was to use longitudinal small animal 18 F-FDG PET imaging to determine a PD specific glucose metabolic brain pattern for a PD rat model. (nature.com)
  • These alterations can be used as longitudinal markers for the disease. (elsevier.com)
  • Spatial regression analysis of serial DTI for subject-specific longitudinal changes of neurodegenerative disease. (rochester.edu)
  • In the current study, we characterized the zQ175 model housed in an academic laboratory under reversed dark-light cycle, including motor function, in vivo longitudinal structural MRI imaging for brain volume, MRS for striatal metabolites, neuropathology, as well as a panel of key disease marker proteins in the striatum at different ages. (duhnnae.com)
  • Mutations in the SMPD1 gene cause Niemann-Pick disease types A and B. They produce a deficiency in the activity of the lysosomal enzyme acid sphingomyelinase, that breaks down the lipid sphingomyelin. (wikipedia.org)
  • MLD is caused by a deficiency of the enzyme arylsulfatase A. MLD is one of several lipid storage diseases, which results in the toxic build-up of fatty materials (lipids) in cells in the nervous system, liver, and kidneys. (clinicaltrials.gov)
  • Blasi P, Giovagnoli S, Schoubben A, Ricci M, Rossi C (2007) Solid lipid nanoparticles for targeted brain drug delivery. (springer.com)
  • A collaborative Stony Brook University research team has discovered a novel metabolic pathway of the lipid ceramide, which is involved in cell death. (medicalxpress.com)
  • Previous reports have shown that this pattern is a useful biomarker of disease progression and of phenoconversion from iRBD to PD. (rug.nl)
  • We expect to find a biomarker useful to follow-up the progression of Pompe disease. (clinicaltrials.gov)
  • To know the natural progression of the disease regarding muscle atrophy measured using muscle MRI during a period of three years. (clinicaltrials.gov)
  • Now, a study published by Cell Press in the October 20 issue of the journal Neuron describes a new and more effective DBS paradigm that makes real-time adjustments in response to disease dynamics and progression and may be better for managing symptoms of advanced PD. (medicalxpress.com)
  • A dihydroflavonoid naringin extends the lifespan of C. elegans and delays the progression of aging-related diseases. (greenmedinfo.com)
  • Our data showed that hematopoietic stem cell transplantation performed at an advanced stage of the cerebral X- linked adrenoleukodystrophy would accelerate the progression of the disease. (sigmaaldrich.com)
  • Starting with an illustrative case, this paper provides a neurologist's approach to the diagnosis, differential diagnosis and management of toxic metabolic encephalopathies. (nih.gov)
  • Treatment of rats with 3-NP altered the motor function, elevated oxidative stress and caused significant histopathological changes in the brain. (springer.com)
  • Methylglyoxal-induced cytotoxicity in neonatal rat brain: a role for oxidative stress and MAP kinases. (sigmaaldrich.com)
  • Causes include genetics, traumatic brain injury, drug reaction, and numerous neurological or metabolic diseases. (prlog.org)
  • For example, blood clots that occur after traumatic brain injury(ie. (healthtap.com)
  • Geoff Manley, MD, PhD, is a leader in the study of traumatic brain injury. (ucsf.edu)
  • The problems and various other aspects of diagnosis of intra- and extra-axial brain tumors (more than 30,000 verified cases) as well as of cerebrovascular, infectious, demyelinating, degenerative and traumatic brain and spine lesions are discussed. (buecher.de)
  • When the film Concussion was released in late 2015, pundits noted that the topic of sports-related traumatic brain injuries (TBIs) had "gone Hollywood. (westonaprice.org)
  • The Centers for Disease Control and Prevention (CDC) categorizes concussions as a "mild" form of TBI but acknowledges that all TBIs disrupt normal brain function. (westonaprice.org)
  • The symptoms of brain ischemia range from mild to severe. (wikipedia.org)
  • however, usually one or more of the symptoms develops later as the disease progresses. (wikipedia.org)
  • Both events occur early in the disease process, even before individuals show any symptoms of cognitive impairment. (plos.org)
  • The main symptoms of Brain ischemia involve impairments in vision, body movement, and speaking. (wikipedia.org)
  • Symptoms of brain ischemia can include unconsciousness, blindness, problems with coordination, and weakness in the body. (wikipedia.org)
  • The symptoms of brain ischemia reflect the anatomical region undergoing blood and oxygen deprivation. (wikipedia.org)
  • Ischemia within the arteries branching from the vertebral arteries in the back of the brain may result in symptoms such as dizziness, vertigo, double vision, or weakness on both sides of the body[citation needed]. (wikipedia.org)
  • If the brain becomes damaged irreversibly and infarction occurs, the symptoms may be permanent. (wikipedia.org)
  • Children with GLUT1 deficiency have an impaired glucose transport into the brain and glucose levels in CSF are low (hypoglychorrhachia). (evidence.nhs.uk)
  • Pyruvate Carboxylase Deficiency Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This graph shows the total number of publications written about "Pyruvate Carboxylase Deficiency Disease" by people in Harvard Catalyst Profiles by year, and whether "Pyruvate Carboxylase Deficiency Disease" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Pyruvate Carboxylase Deficiency Disease" by people in Profiles. (harvard.edu)
  • The astrocyte, one form of glial cell that comprises much of the background substance of the brain and spinal cord, is believed to give rise to a large category of primary brain tumors, the astrocytomas. (mhmedical.com)
  • Do Inflammation & Metabolic Disturbances Metastasize To The Brain? (psychu.org)
  • Additionally, it will discuss how innovative treatment approaches that target metabolic disturbances may have a positive impact on mental health. (psychu.org)
  • A series of deeply interrelated environmental and lifestyle problems-pesticide and chemical toxicity, exposure to heavy metals such as aluminum, poor gut health, overconsumption of processed foods, nutritional deficiencies (especially during the formative years), and insufficient access to sunlight-are setting into motion a perfect storm of events that are making our brains less resilient to shocks and disturbances of all types. (westonaprice.org)
  • Diagnostic testing must include a search for metabolic and infectious derangements. (nih.gov)
  • His work investigates how structural, functional and molecular brain imaging techniques can be used to improve diagnostic accuracy in dementia and to study the biology of neurodegenerative diseases, with the goal of accelerating treatment development. (ucsf.edu)
  • Brain magnetic resonance imaging is a useful diagnostic tool in the initial evaluation of children who appear to have CP. (biomedsearch.com)
  • The treatment for human disease at the earliest stages requires sensitive, quantitative, and non-destructive diagnostic monitoring methods. (chicagobiomedicalconsortium.org)
  • However, their diagnostic accuracy suffers when dealing with complex diseases particularly those that involve multiple domains in medicine. (wiley.com)
  • NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
  • Additionally, it is unclear whether donepezil can protect neurons to improve cognitive function through the brain-derived neurotropic factor (BDNF)/tyrosine receptor kinase B (TrkB) signalling pathway in the tree shrew (TS), which has a closer evolutionary relationship to primates than rodents. (springer.com)
  • It is a complex disease that's driven by multiple factors , such as the loss of neurons and the decrease in the levels of acetylcholine, a neurotransmitter, and choline acetylase, the enzyme involved in its production. (naturalnews.com)
  • Various magnetic resonance (MR) methods [i.e., imaging (MRI), angiography (MRA), and spectroscopy (MRS)], confocal microscopic imaging, and positron emission tomography (PET) provided in vivo metabolic and vascular measures. (frontiersin.org)
  • She is now developing new research lines at CIBM, being oriented towards new acquisition and quantification techniques for in vivo proton, phosphorous, carbon, nitrogen MRS and fast MRSI, diffusion weighted spectroscopy and brain macromolecules quantification. (epfl.ch)
  • 1H-MR spectroscopy, performed in an affected 2-year-old girl with markedly delayed neuromotor development and typical supratentorial white-matter disease (WMD), showed an increase of choline and α-glutamate concentrations. (semanticscholar.org)
  • Magnetic resonance imaging (MRI) is one of the few technologies capable of localized, nondestructive metabolic characterization without ionizing radiation. (chicagobiomedicalconsortium.org)
  • 10(th) centile or abnormal metabolic profile in the frontal lobe. (nih.gov)
  • Brain Diseases, Metabolic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (sickkids.ca)
  • Mutations in NPC1 or NPC2 cause Niemann-Pick disease, type C (NPC), which affects a protein used to transport lipids. (wikipedia.org)
  • Altered spontaneous brain activity pattern in cognitively normal young adults carrying mutations of APP, presenilin-1/2 and APOE ε4. (rochester.edu)
  • However, the effects of mTOR inhibition for in vivo brain physiology remain largely unknown. (frontiersin.org)
  • Here, we review recent findings of in vivo metabolic and vascular measures using non-invasive, multimodal neuroimaging methods in rodent models for brain aging and AD. (frontiersin.org)
  • In 2006 she obtained her PhD degree in Localized Proton MRS and time domain quantification of cerebral metabolites at 7T and 4.7T at University Lyon 1, RMN Laboratory, Villeurbanne, France.In 2007, she joined, as a Scientist, the Laboratory for Functional and Metabolic Imaging at EPFL, where she implemented new acquisition and quantification techniques for in vivo nitrogen, proton and carbon MRS for preclinical studies. (epfl.ch)
  • Development of a new MS-based biomarker for the early and sensitive diagnosis of metachromatic leukodystrophy disease from plasma. (clinicaltrials.gov)
  • Co-researcher Emma Baple says that the current research should help to achieve greater progress in the area of motor neuron disease, eventually leading to better diagnosis and treatment plans - a crucial need in this group of conditions that affects the quality of life of those affected very severely. (news-medical.net)
  • At the time of diagnosis, we recorded fetal head circumference (HC), biparietal diameter, middle cerebral artery pulsatility index (MCA-PI), cerebroplacental ratio (CPR) and brain perfusion by fractional moving blood volume. (nih.gov)
  • This leads to poor oxygen supply or cerebral hypoxia and thus leads to the death of brain tissue or cerebral infarction / ischemic stroke. (wikipedia.org)
  • Similar to cerebral hypoxia, severe or prolonged brain ischemia will result in unconsciousness, brain damage or death, mediated by the ischemic cascade. (wikipedia.org)
  • Failure in diagnosis of WE and thus treatment of the disease leads to death in approximately 20% of cases, while 75% are left with permanent brain damage associated with WKS. (wikipedia.org)
  • The strategic plan of the NIH emphasizes healthcare cost containment through earlier treatment of disease. (chicagobiomedicalconsortium.org)
  • Many care providers mistakenly "see treatment-resistant hypertension as a disease of noncompliance," although it is much more often the result of a missed diagnosis and inadequate intervention, she explained. (medscape.com)
  • Sugar for the brain: the role of glucose in physiological and pathological brain function. (nih.gov)
  • It is our hope that in the near future we will see a new era of DBS strategies, based on real-time adaptive paradigms targeted at different pathological brain activity," conclude Dr. Rosin and Prof. Bergman. (medicalxpress.com)
  • Are metabolic enzymes the pathological trigger? (plos.org)
  • citation needed] Other pathological events that may result in brain ischemia include cardiorespiratory arrest, stroke, and severe irreversible brain damage. (wikipedia.org)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • However, recent findings are beginning to oppose this idea in favor of the hyper-phosphorylated tau hypothesis, which suggests that the mis-sorting of tau proteins in the brain is behind the onset of Alzheimer's . (naturalnews.com)
  • In fact, dysregulation of the GBMAx has been implicated in a variety of gastrointestinal and central nervous system (CNS) diseases. (springermedizin.de)
  • Demyelinating Diseases of the Central Nervous System. (buecher.de)
  • A Machine Learning Approach to Identify a Circulating MicroRNA Signature for Alzheimer Disease. (alzforum.org)
  • Investigating the energy crisis in Alzheimer disease using transcriptome study. (alzforum.org)
  • Association of Early-Onset Alzheimer Disease With Elevated Low-density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB. (ucsf.edu)
  • In rats, the major metabolic pathway of morphine is glucuronidation to morphine-3-glucuronide (M3G) by UDP-glucuronosyltransferase. (scirp.org)
  • Metabolic imaging using both exogenous and endogenous agents is an essential technology for developing such early intervention strategies for humans. (chicagobiomedicalconsortium.org)
  • Memantine is a noncompetitive N-methyl-D-aspartate receptor (NMDAR)ant agoni st that im proves or stabilizes cognitive impairment in moderate to severeAlzheimer's disease (AD). (jneuropsychiatry.org)