Brain diseases metabolic. Medical search

Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.

The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.

Brain disorders resulting from inborn metabolic errors, primarily from enzymatic defects which lead to substrate accumulation, product reduction, or increase in toxic metabolites through alternate pathways. The majority of these conditions are familial, however spontaneous mutation may also occur in utero.

Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.

Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.

Systemic lysosomal storage disease caused by a deficiency of alpha-L-iduronidase (IDURONIDASE) and characterized by progressive physical deterioration with urinary excretion of DERMATAN SULFATE and HEPARAN SULFATE. There are three recognized phenotypes representing a spectrum of clinical severity from severe to mild: Hurler syndrome, Hurler-Scheie syndrome and Scheie syndrome (formerly mucopolysaccharidosis V). Symptoms may include DWARFISM; hepatosplenomegaly; thick, coarse facial features with low nasal bridge; corneal clouding; cardiac complications; and noisy breathing.

Any of various diseases affecting the white matter of the central nervous system.

Acquired or inborn metabolic diseases that produce brain dysfunction or damage. These include primary (i.e., disorders intrinsic to the brain) and secondary (i.e., extracranial) metabolic conditions that adversely affect cerebral function.

Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.

A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.

The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.

Self-renewing cells that generate the main phenotypes of the nervous system in both the embryo and adult. Neural stem cells are precursors to both NEURONS and NEUROGLIA.

Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.

A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.

A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.

Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.

A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.

A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.

The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.

Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

A circumscribed collection of purulent exudate in the brain, due to bacterial and other infections. The majority are caused by spread of infected material from a focus of suppuration elsewhere in the body, notably the PARANASAL SINUSES, middle ear (see EAR, MIDDLE); HEART (see also ENDOCARDITIS, BACTERIAL), and LUNG. Penetrating CRANIOCEREBRAL TRAUMA and NEUROSURGICAL PROCEDURES may also be associated with this condition. Clinical manifestations include HEADACHE; SEIZURES; focal neurologic deficits; and alterations of consciousness. (Adams et al., Principles of Neurology, 6th ed, pp712-6)

A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.

The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.

A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.

Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.

Discussion of lists of works, documents or other publications, usually with some relationship between them, e.g., by a given author, on a given subject, or published in a given place, and differing from a catalog in that its contents are restricted to holdings of a single collection, library, or group of libraries. (from The ALA Glossary of Library and Information Science, 1983)

A list of works, documents, and other publications on medical subjects and topics of interest to the field of medicine.

The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)

The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.

An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.

Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784)

The units based on political theory and chosen by countries under which their governmental power is organized and administered to their citizens.

A prodromal phase of cognitive decline that may precede the emergence of ALZHEIMER DISEASE and other dementias. It may include impairment of cognition, such as impairments in language, visuospatial awareness, ATTENTION and MEMORY.

Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.

Disturbances in mental processes related to learning, thinking, reasoning, and judgment.

An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)

An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.

Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.

Neuropathological findings after bone marrow transplantation: an autopsy study of 180 cases. (1/159)

We prospectively evaluated the neuropathological complications of 180 patients who underwent autopsy studies following bone marrow transplantation (BMT) (177 allogeneic, three autologous). The most frequent underlying disorders included severe aplastic anemia (n = 55), chronic myelogenous leukemia (n = 53), acute myelogenous leukemia (n = 24) and Fanconi anemia (n = 16). There were 114 males and 66 females. Neuropathological findings were detected in 90.55% of the patients. The most frequent findings were subarachnoid hemorrhages (SAH) (n = 57), intraparenchymal hemorrhages (IHP) (n = 49), fungal infections (n = 16), Wernicke's encephalopathy (n = 10), microglial nodular encephalopathy (n = 10) and neurotoxoplasmosis (n = 8). In only 17 patients was the brain within normal limits. Survival time after BMT averaged 5.4 months and the majority of patients died in the first 3 months post BMT (n = 105). Central nervous system (CNS) pathology was the main cause of death in 17% of the patients (n = 31), with a predominance of IHP in this particular group. Furthermore, the survival time of these patients who died of CNS causes (96.3 days) was almost half of the survival time of those who died of extra-cerebral causes (177.8 days) (P = 0.0162). IHP (70. 96 vs27.22%) (P < 0.001), fungal infections (25.8 vs 8.88%) (P < 0. 001) and toxoplasmosis (9.67 vs 4.44%) (P < 0.001) were significantly more frequent in the group of patients who died due to CNS causes than in the control group. The findings of this work provide a possible guide to the possible causes of neurological syndromes following BMT. Bone Marrow Transplantation (2000) 25, 301-307. (+info)

Bone marrow transplantation corrects osteopetrosis in the carbonic anhydrase II deficiency syndrome. (2/159)

Carbonic anhydrase II (CAII), found in renal tubules, brain, and osteoclasts, is critical in acid-base homeostasis and bone remodeling. Deficiency of CAII gives rise to a syndrome of osteopetrosis, renal tubular acidosis (RTA), and cerebral calcification with associated developmental delay. It is inherited in an autosomal recessive fashion and found most frequently in the Mediterranean region and the Middle East. We report 2 related Irish families with clinically severe CAII deficiency in whom the gene mutation has been fully elucidated. Two children, one from each family, have undergone allogeneic bone marrow transplantation because of severe progressive visual and hearing loss. The older 2 children had already developed cerebral calcification and marked visual loss at the time of diagnosis and were treated symptomatically. Post-transplantation evaluation at 2 and 3 years demonstrates histologic and radiologic resolution of their osteopetrosis with stabilization of hearing and vision. Both children remain developmentally delayed and continue to have RTA, and the older child has now developed cerebral calcification. Allogeneic bone marrow stem cell replacement cures the osteoclast component of CAII deficiency and retards the development of cerebral calcification, but it appears to have little or no effect on the renal lesions. (Blood. 2001;97:1947-1950) (+info)

Prognostic significance of cerebral metabolic abnormalities in patients with congestive heart failure. (3/159)

BACKGROUND: Cerebral metabolic abnormalities were proposed as a potential marker of disease severity in congestive heart failure (CHF), but their prognostic significance remains uncertain. METHODS AND RESULTS: We investigated the prognostic value of cerebral metabolic abnormalities in 130 consecutive patients with advanced CHF (100 men aged 42.6+/-11.9 years; left ventricular ejection fraction, 22.2+/-6.2%). Proton magnetic resonance spectroscopy data were obtained from localized regions ( approximately 8 mL) of the occipital gray matter and the parietal white matter. The primary end point was the occurrence of death after the proton magnetic resonance spectroscopy. During follow-up (18.5+/-14.4 months), 21 patients died and 15 underwent urgent heart transplantation. In the Cox proportional model, occipital metabolites (N-acetylaspartate, creatine, choline, and myoinositol), parietal N-acetylaspartate level, and the duration of CHF symptoms (>12 months) were validated as univariate predictors of death. In multivariate Cox analyses, however, the occipital N-acetylaspartate level was an independent predictor of death (hazard ratio, 0.52; 95% CI, 0.41 to 0.67; P<0.001). An analysis with respect to the combined end point of death or urgent transplantation showed similar results. The best cutoff value (9.0 mmol/kg) for occipital N-acetylaspartate level had 75% sensitivity and 67% specificity to predict mortality. CONCLUSIONS: The occipital N-acetylaspartate level is a powerful and independent predictor of CHF mortality, suggesting that cerebral metabolic abnormalities may be used as a new prognostic marker in the assessment of patients with CHF. (+info)

Regression of ventral striatum hypometabolism after calcium/calcitriol therapy in paroxysmal kinesigenic choreoathetosis due to idiopathic primary hypoparathyroidism. (4/159)

A [(18)F]-FDG PET study was performed in a 44 year old man with proximal kinesigenic choreoathetosis (PKC) secondary to idiopathic primary hypoparathyroidism (IPH) before and 1 year after calcium/calcitriol therapy. The [(18)F]-FDG PET performed before the start of the therapy disclosed a significant bilateral hypometabolism in the ventral striatum. One year later, with the patient still under calcium/calcitriol therapy and free of any occurrence of PKC episodes, the [(18)F]-FDG PET did not show the previously detected hypometabolism. The hypometabolism of the ventral striatum secondary to hypocalcaemia seems to play a crucial part in the pathogenesis of paroxysmal kinesigenic choreoathetosis associated with IPH. (+info)

Non-hepatic hyperammonaemia: an important, potentially reversible cause of encephalopathy. (5/159)

The clinical syndrome of encephalopathy is most often encountered in the context of decompensated liver disease and the diagnosis is usually clear cut. Non-hepatic causes of encephalopathy are rarer and tend to present to a wide range of medical specialties with variable and episodic symptoms. Delay can result in the development of potentially life threatening complications, such as seizures and coma. Early recognition is vital. A history of similar episodes or clinical risk factors and early assessment of blood ammonia levels help establish the diagnosis. In addition to adequate supportive care, investigation of the underlying cause of the hyperammonaemia is essential and its reversal, where possible, will often result in complete recovery. Detection of an unborn error of metabolism should lead to the initiation of appropriate maintenance therapy and genetic counselling. (+info)

Glucose and oxygen hypometabolism in aceruloplasminemia brains. (6/159)

OBJECTIVE: Aceruloplasminemia is an iron metabolic disorder caused by mutations in the ceruloplasmin gene. It is characterized by progressive neurodegeneration in association with iron accumulation. Excess iron functions as a potent catalyst of biologic oxidation. Previously we showed that an increased iron concentration is associated with the products of lipid peroxidation in the serum, cerebrospinal fluid, and brain tissues. To clarify the free radical-mediated tissue injury caused by intracellular iron accumulation through mitochondrial dysfunction. PATIENTS AND METHODS: We have measure brain oxygen and glucose metabolisms using positron emission tomography (PET) and examined brains at autopsy for iron contents and activities of the mitochondrial respiratory chain in two affected patients who had different truncation mutations of the ceruloplasmin gene. RESULTS: PET showed a marked decrease in glucose and oxygen consumption in the entire brain of aceruloplasminemia patients, with a preponderance of metabolic reduction in basal ganglia. Enzyme activities in the mitochondrial respiratory chain of the basal ganglia were reduced to approximately 45% and 42% respectively for complexes I and IV. An inverse relationship was shown between the amounts of iron accumulated and the levels of mitochondrial enzyme activities in all the brain regions examined. CONCLUSION: Iron-mediated free radicals may contribute to the impairment of mitochondrial energy metabolism in aceruloplasminemia. (+info)

Fat oxidation defect presenting with overwhelming ketonuria. (7/159)

Ketonuria accompanying hypoglycaemia is conventionally thought to exclude fat oxidation defects. We describe a 2 year old girl with hypoglycaemic encephalopathy in whom a diagnosis of very long chain acyl CoA dehydrogenase deficiency was suggested on the basis of acylcarnitine analysis despite massive ketonuria. (+info)

Axonal damage: a key predictor of outcome in human CNS diseases. (8/159)

Axonal damage has recently been recognized to be a key predictor of outcome in a number of diverse human CNS diseases, including head and spinal cord trauma, metabolic encephalopathies, multiple sclerosis and other white-matter diseases (acute haemorrhagic leucoencephalitis, leucodystrophies and central pontine myelinolysis), infections [malaria, acquired immunodeficiency syndrome (AIDS) and infection with human lymphotropic virus type 1 (HTLV-I) causing HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP)] and subcortical ischaemic damage. The evidence for axonal damage and, where available, its correlation with neurological outcome in each of these conditions is reviewed. We consider the possible pathogenetic mechanisms involved and how increasing understanding of these may lead to more effective therapeutic or preventive interventions. (+info)

Metabolic Brain Disease. 30 (5): 1279-84. doi:10.1007/s11011-015-9672-2. PMID 25920484.. ... Puck JM, Willard HF (January 1998). "X inactivation in females with X-linked disease". The New England Journal of Medicine. 338 ... An extreme case of this was seen where monozygotic female twins had extreme variance in expression of Menkes disease (an X- ... For example, a female heterozygous for haemophilia (an X-linked disease) would have about half of her liver cells functioning ...

https://en.wikipedia.org/wiki/X-chromosome_inactivation

Metabolic Brain Disease. 4 (3): 169-76. doi:10.1007/bf01000293. PMID 2796871. Bergeron, M; Swain, MS; Reader, TA; Grondin, L; ... Metabolic Brain Disease. 17 (4): 463-75. doi:10.1023/A:1021986624600. PMID 12602522. Butterworth, RF (2003). "Role of ... severe metabolic alterations and cerebral edema that can lead to brain death. In these cases the mortality without liver ... pathophysiology and treatment of these diseases Evaluate the clinical impact of MARS therapy on the course of the disease in ...

https://en.wikipedia.org/wiki/Liver_support_system

Metabolic Brain Disease. 28 (2): 151-4. doi:10.1007/s11011-012-9337-3. PMID 23010935. S2CID 11206990. Ortez, C; Jou, C; Cortès- ... doi:10.1093/brain/aws038. ISSN 1460-2156. PMC 3326257. PMID 22396397. Hauser, Robert A (July 6, 2016). "Parkinson Disease ... doi:10.1093/brain/aws038. PMC 3326257. PMID 22396397. Kolb, B. Whishaw, I. (2011) An Introduction to Brain and Behavior, 592. ... "Improved efficacy of temporally non-regular deep brain stimulation in Parkinson's disease". Experimental Neurology. 239: 60-7. ...

https://en.wikipedia.org/wiki/Hypokinesia

Metabolic Brain Disease. 29 (2): 231-243. doi:10.1007/s11011-013-9457-4. ISSN 0885-7490. PMID 24307180. S2CID 17239167. ... "diseases of the mind." Hippocrates writes: Men ought to know that from the brain, and from the brain only, arise our pleasures ... and Parkinson's disease focal neurological disease, such as stroke, brain tumors, multiple sclerosis, and some forms of ... Mashour GA, Walker EE, Martuza RL (June 2005). "Psychosurgery: past, present, and future". Brain Research. Brain Research ...

https://en.wikipedia.org/wiki/Psychosis

Metabolic Brain Disease. 27 (1): 1-5. doi:10.1007/s11011-011-9274-6. PMC 3276770. PMID 22193538. Mashiyama ST, Courtemanche C, ... De Gregori S, De Gregori M, Ranzani GN, Allegri M, Minella C, Regazzi M (2012). "Morphine metabolism, transport and brain ...

https://en.wikipedia.org/wiki/Uracil

Metabolic Brain Disease. 17 (4): 375-387. doi:10.1023/a:1021970120965. ISSN 0885-7490. PMID 12602514. S2CID 23679769. Furrow, S ...

https://en.wikipedia.org/wiki/Briggs–Rauscher_reaction

Metabolic Brain Disease. 23 (1): 115-22. doi:10.1007/s11011-007-9076-z. PMID 18034292. S2CID 9020059. Watson, A. J. S.; Walker ... Metabolic Brain Disease. 14 (1): 1-20. doi:10.1023/A:1020653312697. PMID 10348310. S2CID 19954743. Navarro, Darren; Zwingmann, ... Metabolic Brain Disease. 10 (1): 17-24. doi:10.1007/BF01991779. PMID 7596325. S2CID 9751459.. ... Brain atrophy associated with WKS occurs in the following regions of the brain: the mammillary bodies, the thalamus, the ...

https://en.wikipedia.org/wiki/Wernicke–Korsakoff_syndrome

Metabolic Brain Disease. 31 (3): 631-641. doi:10.1007/s11011-016-9794-1. ISSN 0885-7490. PMC 4863909. PMID 26821073. Al Zarouni ... which can cause brain damage, other organ damage, central nervous system damage and death in sheep. Arundo donax, 0.0057% DMT ...

https://en.wikipedia.org/wiki/List_of_psychoactive_plants

December 2011). "Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse". Metabolic Brain Disease ... Vanier MT, Suzuki K (January 1998). "Recent advances in elucidating Niemann-Pick C disease". Brain Pathology. 8 (1): 163-74. ... Niemann-Pick disease, type C1 (NPC1) is a disease of a membrane protein that mediates intracellular cholesterol trafficking in ... July 1997). "Linkage of Niemann-Pick disease type D to the same region of human chromosome 18 as Niemann-Pick disease type C". ...

https://en.wikipedia.org/wiki/NPC1

Metabolic Brain Disease. 29 (2): 351-7. doi:10.1007/s11011-014-9496-5. PMID 24532047. S2CID 14880172. Roy-Byrne PP, Craske MG, ... Current research also supports this perspective as it has been found that those with panic disorder also have a brain circuit ... "FASTSTATS - Illegal Drug Use". Centers for Disease Control and Prevention. 30 May 2013. Archived from the original on 5 July ... The reason chronic alcohol misuse worsens panic disorder is due to distortion of the brain chemistry and function. ...

https://en.wikipedia.org/wiki/Panic_disorder

Metabolic Brain Disease. 24 (1): 95-102. doi:10.1007/s11011-008-9112-7. hdl:1866/9593. ISSN 0885-7490. PMID 19104924. Mandiga, ... Sleep inversion is a feature of African trypanosomiasis, after which the disease takes its common name, "African sleeping ... Bosoi, Cristina R.; Rose, Christopher F. (March 2009). "Identifying the direct effects of ammonia on the brain". ... Disease". www.cdc.gov. 2020-04-28. Retrieved 2020-08-11. Maxfield, Luke; Bermudez, Rene (2020), "Trypanosomiasis ( ...

https://en.wikipedia.org/wiki/Sleep_inversion

Metabolic Brain Disease. 31 (3): 631-641. doi:10.1007/s11011-016-9794-1. ISSN 0885-7490. PMC 4863909. PMID 26821073. Díaz, J. L ...

https://en.wikipedia.org/wiki/Calea_ternifolia

Wu C, Sun D (April 2015). "GABA receptors in brain development, function, and injury". Metabolic Brain Disease. 30 (2): 367-79 ... AMPARs are found in many parts of the brain and are the most commonly found receptor in the nervous system. The AMPA receptor ... Due to their wide distribution within the nervous system of mammals, they play a role in virtually all brain functions. Various ... At membrane potentials more negative than approximately −50 mV, the Mg2+ in the extracellular fluid of the brain virtually ...

https://en.wikipedia.org/wiki/Ligand-gated_ion_channel

Metabolic Brain Disease. 24 (1): 27-53. doi:10.1007/s11011-008-9118-1. PMID 19085093. Sanacora, G; Treccani, G; Popoli, M ( ... At this time, decreased serotonin levels in the brain and symptoms of depression have not been linked Although there is ... Studies also show that the chronic secretion of stress hormones as a result of disease, including somatic infections or ... Murphy, DL; Andrews, AM; Wichems, CH; Li, Q; Tohda, M; Greenberg, B (1998). "Brain serotonin neurotransmission: An overview and ...

https://en.wikipedia.org/wiki/Pharmacology_of_antidepressants

Metabolic Brain Disease. 22 (3-4): 337-352. doi:10.1007/s11011-007-9064-3. PMID 17712616. S2CID 5823156. Stone TW (April 2001 ... Hypertryptophanemia, is a rare autosomal recessive metabolic disorder that results in a massive buildup of the amino acid ... As the main defect behind hypertryptophanemia is suspected to alter and disrupt the metabolic pathway from tryptophan to ... Stone TW, Mackay GM, Forrest CM, Clark CJ, Darlington LG (July 2003). "Tryptophan metabolites and brain disorders". Clinical ...

https://en.wikipedia.org/wiki/Hypertryptophanemia

Metabolic Brain Disease. 29 (1): 121-30. doi:10.1007/s11011-014-9480-0. PMID 24435938. S2CID 10955351. Piroli GG, Grillo CA, ... Adipose tissue, commonly known as fat, is a depository for energy in order to conserve metabolic homeostasis. As the body takes ... Sonksen P, Sonksen J (July 2000). "Insulin: understanding its action in health and disease". British Journal of Anaesthesia. 85 ... Moreover, impairment in insulin-stimulated trafficking of GLUT4 in the hippocampus result in decreased metabolic activities and ...

https://en.wikipedia.org/wiki/GLUT4

Metabolic Brain Disease Metab Brain Dis. 30 (5): 1279-284. doi:10.1007/s11011-015-9672-2. CS1 maint: Multiple names: authors ... An extreme case of this was seen where monozygotic female twins had extreme variance in expression of Menkes disease (an X- ... Puck, J; Willard, HF (1998). "X Inactivation in Females with X-Linked Disease". N. Engl. J. Med. 338 (5): 325-8. doi:10.1056/ ... For example, a female heterozygous for haemophilia (an X-linked disease) would have about half of her liver cells functioning ...

https://en.wikipedia.org/wiki/X-inactivation

Metabolic brain disease, 32(1), 195-202. "Anatoly Skalny". publications indexed by Google Scholar. Retrieved December 4, 2020. ... Another area of research is studying the effect of the elements' imbalance on the development of various diseases. Anatoly ... and treatment of many diseases. Anatoly Skalny is an editorial board member in two journals in the field of trace elements ...

https://en.wikipedia.org/wiki/Anatoly_Skalny

Metabolic Brain Disease. 13 (2): 97-122. doi:10.1023/A:1020657129593. PMID 9699919.. ... cancer, AIDS,[41] Creutzfeldt-Jakob disease,[7][42] febrile infections[5]. *this disease may even occur in some people with ... Metabolic Brain Disease. 10 (1): 17-24. doi:10.1007/BF01991779. PMID 7596325.. ... pancreatitis, liver dysfunction, chronic diarrhea, celiac disease, Crohn's disease, uremia,[35] thyrotoxicosis[40] ...

https://en.m.wikipedia.org/wiki/Wernicke's_encephalopathy

"Brain metabolic effects of Neotrofin in patients with Alzheimer's disease". Brain Research. 951 (1): 87-95. doi:10.1016/s0006- ... It stimulates release of nerve growth factors and enhances survival of neurons in the brain, and is under development as a ... Johnston TH, Brotchie JM (July 2004). "Drugs in development for Parkinson's disease". Current Opinion in Investigational Drugs ... potential treatment for neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and stroke. Di Iorio P, ...

https://en.wikipedia.org/wiki/Leteprinim

Metabolic Brain Disease. 17 (4): 375-87. doi:10.1023/A:1021970120965. PMID 12602514. S2CID 23679769. Cersosimo, M. G.; Koller, ... Takeda, A. (2003). "Manganese action in brain function". Brain Research Reviews. 41 (1): 79-87. doi:10.1016/S0165-0173(02)00234 ... Unlike Parkinson's disease, manganism is not associated with loss of the sense of smell and patients are typically unresponsive ... In the human brain, the manganese is bound to manganese metalloproteins, most notably glutamine synthetase in astrocytes. ...

https://en.wikipedia.org/wiki/Manganese

They include toxic, metabolic, degenerative diseases, traumatic brain injury, or thrombotic or embolic stroke.[citation needed ... Huntington's disease, Niemann-Pick disease, and Friedreich's ataxia.[citation needed] Toxic and metabolic conditions include: ... Brain tumor Cerebral palsy Guillain-Barré syndrome Hypothermia Lyme disease Stroke Idiopathic intracranial hypertension ( ... formerly known as pseudotumor cerebri) Tay-Sachs disease, and late-onset Tay-Sachs disease (LOTS) Dysarthrias are classified in ...

https://en.wikipedia.org/wiki/Dysarthria

Clinical use of proton spectroscopy Maturation, abnormalities and metabolic diseases of children's brains Functional imaging of ... PMID 1974962 Grodd, W., Krägeloh-Mann, I., Klose, U., and Sauter, R. (1991). Metabolic and destructive brain disorders in ... In vivo assessment of N-acetylaspartate in brain in spongy degeneration (Canavan's disease) by proton spectroscopy. Lancet 336 ... Hum Brain Mapp 8, 157-169. PMID 10619411 Heun, R., Freymann, K., Erb, M., Leube, D.T., Jessen, F., Kircher, T.T., and Grodd, W ...

https://en.wikipedia.org/wiki/Wolfgang_Grodd

NGF and Related Molecules in Health and Disease. Progress in Brain Research. 146. pp. 111-26. doi:10.1016/S0079-6123(03)46008-1 ... and metabolic syndrome.[46] Reduced plasma levels of NGF and BDNF have been associated with acute coronary syndromes and ... a role for NGF and BDNF in cardiovascular disease?". Progress in Brain Research. 146: 279-89. doi:10.1016/S0079-6123(03)46018-4 ... from animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer's disease". Progress in Brain Research. ...

https://en.wikipedia.org/wiki/Nerve_growth_factor

OPCA may also be found in the brains of individuals with prion disorders and inherited metabolic diseases. The characteristic ... This is more likely as the disease progresses; it is possible to have OPCA and have a normal brain MRI (especially within the ... MRI of the brain may show characteristics of OPCA, such as specific changes in the size of affected parts of the brain. ... areas of brain damage that indicate OPCA can be seen by imaging the brain using CT scans or MRI studies. The term was ...

https://en.wikipedia.org/wiki/Olivopontocerebellar_atrophy

Proteome-based plasma biomarkers for Alzheimer's disease." Brain 129: 3042-3050, (2006). ... "Pathway Analysis of Kidney Cancer Using Proteomics and *Metabolic Profiling." Biomed Central: 65-82, (24 नवम्बर 2006). ... "Biomarkers of cardiovascular disease: molecular basis and practical considerations" Circulation. 2006;113:2335-2362. ... "Platelet Genomics and Proteomics in Human Health and Disease." The Journal of Clinical Investigation 115: 3370-3377, (December ...

https://hi.wikipedia.org/wiki/प्रोटीनोमिक्स

... metabolic derangement, and brain lesions such as strokes. Several neurodegenerative disorders also may present with ... doi:10.1093/brain/aws038. PMC 3326257. PMID 22396397.. *^ "Parkinson's Disease vs. Parkinsonism" (PDF). National Parkinson ... to distinguish it from other neurodegenerative diseases, such as Alzheimer's disease where the brain accumulates tau protein.[ ... Maria, Nord (2017). Levodopa pharmacokinetics -from stomach to brain A study on patients with Parkinson's disease. Linköping: ...

https://en.wikipedia.org/?title=Parkinson's_disease

N. Duarte, João M (2015). "Metabolic Alterations Associated to Brain Dysfunction in Diabetes". Aging and Disease. 6 (5): 304-21 ... and to the creation of mathematical model of brain metabolism encompassing quantitative metabolic rates in the live brain. More ... his contributions led to the direct measurement of brain glucose levels in human brain over time; to the in vivo measurement of ... to the diagnosis and quantification of glutathione and vitamin C in the brain; and to the in vivo mensuration of brain glycogen ...

https://en.wikipedia.org/wiki/Rolf_Gruetter

Implications for Alzheimer's disease". Brain. 122 (8): 1519-1531. doi:10.1093/brain/122.8.1519. ISSN 1460-2156.. ... metabolic abnormality is linked to amyloid deposition and brain atrophy with a spatial distribution that resembles the nodes of ... doi:10.1093/brain/awt162. PMC 3891440. PMID 23869106.. *^ a b c d e Pearson, John M.; Heilbronner, Sarah R.; Barack, David L.; ... Alzheimer's disease[edit]. The PCC is commonly affected by neurodegenerative disease.[15] In fact, reduced metabolism in the ...

https://en.wikipedia.org/wiki/Posterior_cingulate_cortex

Other causes include toxins within the brain, autoimmune disease, and infections, which include meningitis. Since the basal ... Hyperkinesia can be caused by a large number of different diseases including metabolic disorders, endocrine disorders, ... Deep Brain Stimulation surgery targeting the globus pallidus, thalamus and other areas of the brain may be effective in ... Parkinson's disease was one of the first disorders to be named as a result of the recent classification of its featured ...

https://en.wikipedia.org/wiki/Hyperkinesia

Metabolic alterations in MS Last post by frodo « Wed Sep 15, 2021 10:53 am Posted in MS Etiology and Pathogenesis ... Focus on the gut-brain axis Last post by Petr75 « Tue Sep 21, 2021 7:47 am Posted in General Discussion ... Sex & Gender in Health & Disease Last post by Leonard « Wed Sep 15, 2021 2:54 am Posted in General Discussion ... How major fungal infections can initiate severe autoimmune diseases Abstract. Several autoimmune... ...

https://www.thisisms.com/forum/search.php?search_id=active_topics

Tulsi reduces total cholesterol levels, thus it is useful for heart disease patients. ... Ayurvedic practice recommends Tulsi in several formulations to enhance immunity and metabolic functions as well as in the ... Is a powerful food for the brain.. *Amla helps in lowering cholesterol level. ... amla can definitely keep a number of diseases at bay. ...

https://www.myaplombbusiness.com/Default.aspx?action=productpage&pcid=1&pid=271

A difuse area of gray enigma everywhere in the brain stem, known as the reticular crystallization, is coupled to sleep and ... An out of doors worker has been recognized with and handled for Lyme disease and continues to have non-particular symptoms. ... toxic substances and metabolic derangements. Pathologies of the Vestibular System There are numerous completely different ... Table 21 lists selected sexually transmissible microorganisms and the diseases they cause. With respect to different so matic ...

http://wp.ospreyspecimengroup.com/phpbb/viewtopic.php?t=1&f=2

Evidence suggests sugar consumption plays greater role in heart disease than saturated fat Last post by RitaA « Thu 5 May 2016 ... Test Of Experimental Alzheimers Drug Finds Progress Against Brain Plaques Last post by amr « Fri 4 Nov 2016 4:17 ... A Diagnostic Algorithm for Metabolic Myopathies Last post by RitaA « Sat 29 Aug 2015 18:26 ... Infectious Agents and Neurodegenerative Diseases: Exploring the links Last post by lou « Tue 24 Jan 2017 3:51 ...

https://www.lymeneteurope.org/forum/viewforum.php?f=13

Lipodystrophy & Metabolic Problems. Nutrition & HIV. Research News & Studies. Off Topic Forums. Off Topic Forum. Forums ... Theres much more to life than disease prevention. As long as I keep anxiety to a manageable level, I dont think anything ... not because I need to taught about this disease. You all are important to me in your respective ways and I dont understand the ...

https://forums.poz.com/index.php?topic=36769.msg458077

IpsiHand retrains the brain and restores hand function Last post by NHE « Sun Jun 13, 2021 7:15 pm Posted in Medical Devices ... Metabolic alterations in MS Last post by frodo « Wed Sep 15, 2021 10:53 am Posted in MS Etiology and Pathogenesis ... Magnesium in Infectious Diseases in Older People (2021) Reduced magnesium (Mg) intake is a frequent cause of deficiency with ... Metabolic abnormalities in MS Last post by frodo « Sat Jul 31, 2021 5:08 am Posted in MS Etiology and Pathogenesis ...

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most diseases are caused by faulty diets and can be prevented by nutritional interventions any use of food additives and ... What is more, even if the brain were a quantum system, that would not imply that it can break the laws of physics any more than ... as well as measures to rid the body of certain toxins and metabolic byproducts that are thought to accumulate, to the detriment ... Disease is thought to arise from imbalance or stress in an individuals conciousness, and is exacerbated by unhealthy ...

http://www.ebvet.com/forum/viewtopic.php?p=192

http://www.ebvet.com/forum/viewtopic.php?p=2233

http://www.ebvet.com/forum/viewtopic.php?p=630

IpsiHand retrains the brain a… by NHE View the latest post Sun Jun 13, 2021 7:15 pm ... Metabolic alterations in MS by frodo View the latest post Wed Sep 15, 2021 10:53 am ... Options for basing Dietary Reference Intakes (DRIs) on chronic disease endpoints: report from a joint US-/Canadian-sponsored... ... Gilenya, or Fingolimod, is the first approved oral disease modifying drug for MS. Topics: 153 ...

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Lipodystrophy & Metabolic Problems. Nutrition & HIV. Research News & Studies. Off Topic Forums. Off Topic Forum. Forums ... 2) I have some other disease like cancer too and they are scrambling to figure out how to tell me Not Likely. 3) I have a ... Meningitis and other brain infections Fungal infections Malignancies such as lymphoma, cervical cancer, and Kaposis Sarcoma. ... 2) I have some other disease like cancer too and they are scrambling to figure out how to tell me. 3) I have a bizarre strain ...

https://forums.poz.com/index.php?topic=9310.msg113689

https://forums.poz.com/index.php?topic=9310.msg113931

https://forums.poz.com/index.php?topic=9310.msg113660

https://forums.poz.com/index.php?topic=9310.msg113828

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Lipodystrophy & Metabolic Problems. Nutrition & HIV. Research News & Studies. Off Topic Forums. Off Topic Forum. Forums ... your count of 19 is no doubt close to mine.I dont know for sure and would hurt my small brain to remember all of them.Good ole ... I still have GI disease even today, and a lot of joint inflammation, as well a neuropathy in my feet & hands. also I have ...

https://forums.poz.com/index.php?topic=36945.msg613947

Lipodystrophy & Metabolic Problems. Nutrition & HIV. Research News & Studies. Off Topic Forums. Off Topic Forum. Forums ... Im not riding the roads like I use to since I have had a small battle with prostate cancer and kidney disease but am still ... I advanced to AIDS in 1995 after having a cyst erupt between the lobes of my brain (not HIV related) for which I ended up ... This stimulates a part of the brain that they think is responsible for depression. Ive had 15 or 16 treatments. Im not ...

https://forums.poz.com/index.php?topic=11342.msg242835

Brain metabolic dysfunction is known to influence brain activity in several neurological disorders, including Alzheimer's disease (AD). (frontiersin.org)
In the central nervous system, mTOR inhibition demonstrates neuroprotective patterns in aging and Alzheimer's disease (AD) by preserving mitochondrial function and reducing amyloid beta retention. (frontiersin.org)
Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer's disease. (inserm.fr)
A sensitive marker for monitoring progression of early Alzheimer's disease would help to develop and test new therapeutic strategies. (inserm.fr)
Neuropsychiatric subsyndromes and brain metabolic network dysfunctions in early onset Alzheimer's disease. (escholarship.org)
In this review, we provide information about the associations of physical activity (PA) with major age-related neurodegenerative diseases and syndromes, including Alzheimer's disease, vascular dementia, and mild cognitive impairment. (mdpi.com)
There are now an estimated 5.4 million Americans (one in nine), aged 65 years and older, with Alzheimer's disease (AD), the most common form of dementia, and this number is expected to almost triple by 2050, as the population ages [ 3 ]. (mdpi.com)
Boeve BF (2012) Mild cognitive impairment associated with underlying Alzheimer's disease versus Lewy body disease. (springer.com)
Prevalence of cardiovascular drug use before and after diagnosis of Alzheimer's disease. (alzforum.org)
β-Amyloid Peptide: the Cell Compartment Multi-faceted Interaction in Alzheimer's Disease. (alzforum.org)
Role for ATXN1, ATXN2, and HTT intermediate repeats in frontotemporal dementia and Alzheimer's disease. (alzforum.org)
Brain metabolic signatures across the Alzheimer's disease spectrum. (alzforum.org)
Is the Subject Area "Alzheimer's disease" applicable to this article? (plos.org)
Alzheimer's disease (AD) is the most common dementia, and the development of drug therapies for AD has advanced in recent years. (jneuropsychiatry.org)
Cortical metabolism declines as Alzheimer's disease progresses [ 10 - 13 ]. (jneuropsychiatry.org)
Alzheimer's disease (AD) is a progressive disorder associated with disruption of neuronal function and neuronal loss. (elsevier.com)
TgF344-AD is a transgenic rat model of Alzheimer's disease (AD) that shows all its pathological hallmarks in a progressive way. (ismrm.org)
On the research front, he leads the MAC PET imaging program , is principal investigator of a cohort study of early-onset Alzheimer's disease and of Imaging Dementia: Evidence for Amyloid Scanning (IDEAS), a U.S.-wide study sponsored by the Centers for Medicare and Medicaid Services to assess the clinical utility of amyloid PET in 18,500 Medicare beneficiaries. (ucsf.edu)
Awards recognizing his work include the 2015 Christopher Clark Award for Advancement of the Field of Amyloid Imaging, the 2012 American Academy of Neurology Research Award in Geriatric Neurology and the 2010 Best Paper in Alzheimer's Disease Neuroimaging: New Investigator Award from the Alzheimer's Association. (ucsf.edu)
Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease. (ucsf.edu)
Alzheimer's pathology targets distinct memory networks in the ageing brain. (ucsf.edu)
Alzheimer's disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation. (ucsf.edu)
Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain. (ucsf.edu)
A research team at the University of Miami Miller School of Medicine's Center for Therapeutic Innovation ( CTI ) has identified a novel epigenetic drug target to simultaneously normalize multiple deficits in Alzheimer's disease (AD), the most common form of dementia in the elderly and the sixth leading cause of death in the U.S., according to the Alzheimer's Association. (healthcanal.com)
The researchers demonstrated that epigenetic "eraser" enzyme, histone deacetylase 3 (HDAC3) is connected to multiple Alzheimer's disease hallmarks, including beta-amyloid (Aβ), hyperphosphorylated tau and several other aberrant genes. (healthcanal.com)
His laboratory conducted the new study, which was supported by the National Institutes of Health and the State of Florida Department of Health (the Ed and Ethel Moore Alzheimer's Disease Research Program). (healthcanal.com)
We were able to demonstrate that it is possible to re-program neuronal cell gene expression and thereby achieve a very striking reversal of deteriorating memory in our Alzheimer's disease model. (healthcanal.com)
Efficacy was investigated by the change of the scores of Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-Cog), Activities of Daily Life (ADL) and Unified Parkinson's Disease Rating Scale (UPDRS) part III (motor scale). (scirp.org)
The Mitochondrial Hypothesis: Is Alzheimer's a Metabolic Disease? (plos.org)
Despite decades of research devoted to understanding its origins, Alzheimer's disease remains a daunting and devastating neurological mystery, ranking as the sixth leading killer of Americans. (plos.org)
A common thread across many of these drugs is their targeting the defining marker of the disease, amyloid plaques - those nasty extracellular deposits of beta-amyloid protein that invariably present in the Alzheimer's brain and are thought to be toxic to neurons. (plos.org)
Its proponents posit that mitochondrial dysfunction lies at the heart of neural degeneration, driven by metabolic abnormalities which lead to classic Alzheimer's pathology. (plos.org)
So if mitochondrial dysfunction initiates the Alzheimer's cascade, what are the steps leading from metabolic disruption to neurodegeneration and ultimately, dementia? (plos.org)
its activity is reduced not just in those with Alzheimer's , but even in asymptomatic individuals who are at genetic risk for the disease or had a mother with Alzheimer's . (plos.org)
For the mitochondrial theory to hold water, it must critically account for the classic pathological markers that define Alzheimer's and have shaped traditional disease models - namely, amyloid plaques, tau tangles and brain atrophy. (plos.org)
LA JOLLA, CALIF. - Nov. 21, 2018 - Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified gene recombination in neurons that produces thousands of new gene variants within Alzheimer's disease brains. (eurekalert.org)
Using new analytical methods focused on single and multiple-cell samples, the researchers found that the APP gene, which produces the toxic beta amyloid proteins defining Alzheimer's disease, gives rise to novel gene variants in neurons--creating a genomic mosaic. (eurekalert.org)
Gene recombination was discovered as both a normal process for the brain and one that goes wrong in Alzheimer's disease. (eurekalert.org)
One hundred percent of the Alzheimer's disease brain samples contained an over-abundance of distinct APP gene variants, compared to samples from normal brains. (eurekalert.org)
Among these Alzheimer's-enriched variations, the scientists identified 11 single-nucleotide changes identical to known mutations in familial Alzheimer's disease--a very rare inherited form of the disorder. (eurekalert.org)
Although found in a mosaic pattern, the identical APP variants were observed in the most common form of Alzheimer's disease, further linking gene recombination in neurons to disease. (eurekalert.org)
These findings may fundamentally change how we understand the brain and Alzheimer's disease," says Chun. (eurekalert.org)
The secret code is being used in healthy brains but also appears to be disrupted in Alzheimer's disease. (eurekalert.org)
Although there is no medical evidence that HIV or AIDS causes Alzheimer's disease, existing FDA-approved antiretroviral therapies for HIV that block reverse transcriptase might also be able to halt the recombination process and could be explored as a new treatment for Alzheimer's disease. (eurekalert.org)
The scientists noted the relative absence of proven Alzheimer's disease in aging HIV patients on antiretroviral medication, supporting this possibility. (eurekalert.org)
Our findings provide a scientific rationale for immediate clinical evaluation of HIV antiretroviral therapies in people with Alzheimer's disease," says Chun. (eurekalert.org)
Such studies may also be valuable for high-risk populations, such as people with rare genetic forms of Alzheimer's disease. (eurekalert.org)
This helps explain why copies of the APP gene are not accurate in Alzheimer's disease and how the diversity of DNA in the neurons is created. (eurekalert.org)
The amyloid hypothesis, or the theory that accumulation of a protein called beta-amyloid in the brain causes Alzheimer's disease, has driven Alzheimer's research to date. (eurekalert.org)
The thousands of APP gene variations in Alzheimer's disease provide a possible explanation for the failures of more than 400 clinical trials targeting single forms of beta-amyloid or involved enzymes," says Chun. (eurekalert.org)
APP gene recombination in Alzheimer's disease may be producing many other genotoxic changes as well as disease-related proteins that were therapeutically missed in prior clinical trials. (eurekalert.org)

Metabolic Brain Disease is directed to neuroscientists, psychiatrists, neurologists, pathologists, and others involved in the research and treatment of a broad range of brain disorders. (springer.com)
Brain diseases include many different areas and etiologies, but generically this refers to disorders of the brain tissue. (healthtap.com)
Besides deficits in glucose utilization in AD patients, recent evidence has implicated neuroinflammation and endoplasmic reticulum (ER) stress as components of a novel form of brain metabolic stress that develop in AD and other neurological disorders. (frontiersin.org)
A similar scenario has been recently described in the brains of patients that suffer from neurodegenerative disorders, such as AD. (frontiersin.org)
Such findings may impact translational research, as treating brain metabolic dysfunction might be a key strategy to fight neurological disorders. (frontiersin.org)
These include primary (i.e., disorders intrinsic to the brain) and secondary (i.e., extracranial) metabolic conditions that adversely affect cerebral function. (sickkids.ca)
Genetic brain disorders affect the development and function of the brain. (medlineplus.gov)
Some genetic brain disorders are due to random gene mutations or mutations caused by environmental exposure, such as cigarette smoke. (medlineplus.gov)
Many people with genetic brain disorders fail to produce enough of certain proteins that influence brain development and function. (medlineplus.gov)
These brain disorders can cause serious problems that affect the nervous system. (medlineplus.gov)
Experts argue whether Wernicke-Korsakoff syndrome (WKS) is two separate but linked disorders, or if it is a spectrum of a single disease state . (medicalnewstoday.com)
This event will discuss the effect of inflammation and metabolic disturbances on mood disorders. (psychu.org)
Consistent with its critical role for physiological brain function, disruption of normal glucose metabolism as well as its interdependence with cell death pathways forms the pathophysiological basis for many brain disorders. (nih.gov)
Such strategies have potential not only for the treatment of PD, but perhaps other neurological disorders with a clear pathological pattern of brain activity . (medicalxpress.com)
With some of these disorders, if treated early, brain dysfunction can be reversible. (medlineplus.gov)
Metabolic disorders may cause confusion and changes in thinking or reasoning. (medlineplus.gov)
To rule out certain brain disorders, an EEG (electroencephalogram), head CT scan , or head MRI scan is usually done. (medlineplus.gov)
With some metabolic disorders, treatment may stop or even reverse the dementia symptoms. (medlineplus.gov)
Medicines used to treat Alzheimer disease have not been shown to work for these types of disorders. (medlineplus.gov)
Toxic and Metabolic Disorders. (buecher.de)
Experienced clinicians recognize that some children who appear to have static cerebral palsy (CP) actually have underlying genetic-metabolic disorders. (biomedsearch.com)
We report a series of patients with motor disorders seen in children with extrapyramidal CP in whom brain magnetic resonance imaging abnormalities provided important diagnostic clues in distinguishing genetic-metabolic disorders from other causes. (biomedsearch.com)
Other signal abnormalities and atrophy in the putamen, globus pallidus, or caudate can point to genetic-metabolic diseases, including disorders of mitochondrial and organic acid metabolism. (biomedsearch.com)
Progress in understanding and treating genetic diseases of the developing brain makes it essential to diagnose disorders that masquerade as static CP. (biomedsearch.com)
The objectives of the present study were to determine the prevalence of developmental defects of the corpus callosum in patients attending a genetics-metabolic disorders clinic, to describe the spectrum of abnormalities in brain development in patients with confirmed inborn errors of metabolism and abnormalities of the corpus callosum as ascertained by neuroimaging and/or postmortem studies. (biomedsearch.com)
Naringin is a potential therapeutic agent which could play an important role in the management of metabolic disorders. (greenmedinfo.com)
Some of the symptoms that can occur with metabolic disorders are lethargy , weight loss , jaundice and seizures . (wikipedia.org)
Inherited metabolic disorders are one cause of metabolic disorders, and occur when a defective gene causes an enzyme deficiency. (wikipedia.org)
Metabolic disorders can be present at birth, and many can be identified by routine screening. (wikipedia.org)
Specific blood and DNA tests can be done to diagnose genetic metabolic disorders. (wikipedia.org)
Metabolic disorders can be treatable by nutrition management, especially if detected early. (wikipedia.org)

This is a naturalistic study in which clinical evaluations and brain scans will be performed on 72 people with Down syndrome (DS), 36 non-demented and 36 with dementia, as well as 36 age-matched healthy controls. (clinicaltrials.gov)
Is Metabolic Syndrome dumbing down the teenage brain? (pritikin.com)
Yes, suggests new research, which found lower reading and math scores and other measures of cognitive ability among U.S. teens with the Metabolic Syndrome. (pritikin.com)
What is the Metabolic Syndrome, and what can we do about it? (pritikin.com)
A new study published in the medical journal Pediatrics found that overweight or obese teens with the Metabolic Syndrome "showed significantly lower arithmetic, spelling, attention, and mental flexibility and a trend for lower overall intelligence, " reported the New York University School of Medicine authors. (pritikin.com)
What is the Metabolic Syndrome? (pritikin.com)
The Metabolic Syndrome is a cluster of factors indicating a dysfunctional metabolism. (pritikin.com)
Government health surveys estimate that nearly 1 in 10 U.S. teens - and more than one-third of overweight and obese teens - have the Metabolic Syndrome. (pritikin.com)
For years, scientists have known that the Metabolic Syndrome can greatly increase the risk of diabetes and heart attacks. (pritikin.com)
But they assumed that the brain dysfunction seen in adults had happened after many years, maybe even decades, of living with the syndrome. (pritikin.com)
It suggests that if you have the Metabolic Syndrome in your adolescent years, you may be suffering some of its damaging effects - in your adolescent years. (pritikin.com)
Shockingly, the NYU scientists also found that the syndrome affected the physical nature of the brain. (pritikin.com)
They took MRIs of 49 teens with the Metabolic Syndrome as well as MRIs of 62 other teens who were syndrome-free, and discovered that the youth with the syndrome had "smaller hippocampal volumes" (the hippocampus plays a major role in the learning and recall of new information), as well as other brain changes, including "reductions of microstructural integrity in major white matter tracts. (pritikin.com)
And the more Metabolic Syndrome factors the teenagers had, the greater the brain impairments were. (pritikin.com)
In all three studies, tracking overweight children ages 8 to 17 who arrived at Pritikin with the Metabolic Syndrome, the scientists found that 100% of the children were able to reduce several metabolic risk factors, including triglycerides, blood pressure, and blood sugar. (pritikin.com)
And 100% of the children returned home no longer classified as having the Metabolic Syndrome. (pritikin.com)
It is poor food and fitness that cause the Metabolic Syndrome. (pritikin.com)
Not so with the Metabolic Syndrome. (pritikin.com)
Intrinsic brain abnormalities in irritable bowel syndrome and effect of anxiety and depression. (rochester.edu)
Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial. (ucsf.edu)
Metabolic syndrome increases the risk for development of heart disease. (bioportfolio.com)
Another condition associated with metabolic syndrome is fatty liver disease which is also referred to as nonalcoholic fatty liver disease (NAFLD). (bioportfolio.com)
The present study will test the drug 3-V Bioscience-2640 in healthy subjects with characteristics of the metabolic syndrome before and after 10 days of treatment to determine if 200 mg/d significantly reduces liver fat synthesis and lowers liver fat storage. (bioportfolio.com)
Here, the subjects will be men with characteristics of the metabolic syndrome, who are otherwise healthy. (bioportfolio.com)
The focus on subjects with metabolic syndrome is based on the fact that the future use of the drug will be in patients with NAFLD who will likely have metabolic syndrome characteristics. (bioportfolio.com)
14 A 2014 study in Surgical Neurology International coined a term for this increasingly prevalent problem: "diminished brain resilience (DBR) syndrome. (westonaprice.org)
Not to be confused with Metabolic syndrome or Diabetes . (wikipedia.org)
Subscribe to the world's most popular newsletters for Fibromyalgia, ME/CFS (Chronic Fatigue Syndrome) and Lyme Disease. (prohealth.com)

Acquired or inborn metabolic diseases that produce brain dysfunction or damage. (sickkids.ca)
In 2001, I joined the faculty of the Department of Biophysics at MCW, where I continue my work on redox mechanisms of cardiovascular and fetal brain dysfunction. (mcw.edu)
These, in conjunction with an underlying deficiency in long chain PUFA, may damage the arcuate nucleus as well as neuropeptide-Y and pro-opiomelanocortin neurons and insulin receptors in the brain, especially during fetal life, infancy, and childhood, resulting in their dysfunction(32). (blogspot.com)
Cattaneo E (2003) Dysfunction of wild type huntingtin in Huntington disease. (springer.com)

2019). "Sodium and water handling during hemodialysis: new pathophysiologic insights and management approaches for improving outcomes in end-stage kidney disease. (nottingham.ac.uk)
2019). Lipid metabolic pathways converge in motor neuron degenerative diseases. (news-medical.net)
CHICAGO - Aug. 26, 2019 - PRLog -- An estimated 250,000 people in the United States have dystonia, a chronic movement disorder affecting the brain and nervous system. (prlog.org)

Background: iRBD is commonly considered to be a prodromal stage of alpha-synucleinopathies such as Parkinson's disease (PD), Dementia with Lewy Bodies (DLB), or Multiple System Atrophy (MSA). (rug.nl)
Methods: In our first study ("REMPET1"), 21 iRBD patients without parkinsonism or dementia, 19 controls, 20 PD patients, and 22 DLB patients underwent static [18F]FDG-PET brain imaging. (rug.nl)
Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study. (alzforum.org)
His work investigates how structural, functional and molecular brain imaging techniques can be used to improve diagnostic accuracy in dementia and to study the biology of neurodegenerative diseases, with the goal of accelerating treatment development. (ucsf.edu)
Many patients with Parkinson's disease suffer cognitive impairment or dementia. (scirp.org)
Cholinesterase inhibitors (ChEIs) have positive effects on patients with Parkinson's Disease Dementia (PDD). (scirp.org)
Aarsland, D., Zaccai, J. and Brayne, C. (2005) A Systematic Review of Prevalence Studies of Dementia in Parkinson's Disease. (scirp.org)
Fletcher, P., Leake, A. and Marion, M.H. (2011) Patients with Parkinson's Disease Dementia Stay in the Hospital Twice as Long as Those without Dementia. (scirp.org)
Dementia is loss of brain function that occurs with certain diseases. (medlineplus.gov)
Dementia due to metabolic causes is a loss of brain function that can occur with abnormal chemical processes in the body. (medlineplus.gov)
Outcome varies, depending on the cause of the dementia and the amount of damage to the brain. (medlineplus.gov)
Treating the underlying cause may reduce the risk for metabolic dementia. (medlineplus.gov)
In the terminal stages of Niemann-Pick type C disease, the patient is bedridden, with complete ophthalmoplegia, loss of volitional movement and severe dementia. (wikipedia.org)

We investigated the glucose metabolism in an adeno-associated viral vector based alpha-synuclein rat model for Parkinson's disease (PD) using longitudinal 18 F-FDG PET imaging, which resulted in an improved characterization of this animal model. (nature.com)
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that typically occurs in elderly people and affects about one percent of persons older than 60 years 1 . (nature.com)
Neuroprotective effect of crocin against rotenone-induced Parkinson's disease in rats: Interplay between PI3K/Akt/mTOR signaling pathway and enhanced expression of miRNA-7 and miRNA-221. (alzforum.org)
Parkinson's disease (PD) is a devastating and incurable disease that causes abnormal poverty of movement, involuntary tremor, and lack of coordination. (medicalxpress.com)
Jankovic, J. (2008) Parkinson's Disease: Clinical Features and Diagnosis. (scirp.org)
Bedard C, Wallman MJ, Pourcher E, Gould PV, Parent A, Parent M (2011) Serotonin and dopamine striatal innervation in Parkinson's disease and Huntington's chorea. (springer.com)

Consideration of Sex Differences in the Measurement and Interpretation of Alzheimer Disease-Related Biofluid-Based Biomarkers. (alzforum.org)
The principal objective of the study is to find biomarkers that quantify the natural progression of the disease and to know if they are useful to determine the improvement or lack of impairment of the disease in response to Enzyme Replacement Therapy (ERT). (clinicaltrials.gov)
Measurements of MDA, HNE and carbonyl groups, biomarkers of lipid peroxidation and protein oxidation respectively, were found to be statistically significantly increased in TAA-rats compared to control-rats (3.16-, 2.44- and 1.95-fold, respectively), reflecting the presence of oxidative stress in the brain of TAA-rats. (scirp.org)
No statistical significant differential protein expression in the cortex of TAA-rats was observed, although oxidative stress biomarkers for lipid and proteins were higher in the brain of TAA-rats than in control-rats. (scirp.org)

Enlargement of the spleen or liver frequently becomes less apparent with time, in contrast to the progression of other lysosomal storage diseases such as Niemann-Pick disease, Types A and B or Gaucher disease. (wikipedia.org)

We discuss here potential mechanisms by which metabolic defects affect diverse biochemical pathways, altering key neurobiological processes (e.g. defective cell membrane formation, cellular bioenergetics and cell-to-cell signaling), that eventually lead to structural abnormalities in the developing nervous system. (biomedsearch.com)
Defect in gene transcription, excitotoxicity, neuroinflammation and oxidative stress are the dominant disease process that causes striatal cell loss with motor abnormalities in Huntington's disease (HD). (springer.com)

Metabolic Brain Disease serves as a forum for the publication of outstanding basic and clinical papers on brain diseases, including both human and animal studies. (springer.com)
Conclusion:Our preliminary findings show that abnormal metabolic expression begins years before clinical manifestation of parkinsonian symptoms in iRBD patients, and that changes in PDRP expression over time may provide a useful metric for predicting phenoconversion to alpha-synucleinopathy diseases. (rug.nl)
The present study is aimed at investigating brain metabolism changes over time, as a potential monitoring marker, in patients with amnestic mild cognitive impairment, according to their clinical outcome (converters or non-converters), and in relation to their cognitive decline. (inserm.fr)
This Physician Initiated Request program allows physicians to request permission from Amicus to receive migalastat HCl for specific patients with Fabry disease who have a mutation amenable to this treatment, who do not have access to available treatment alternatives, or do not meet requirements for participation in an existing migalastat clinical study. (clinicaltrials.gov)
This project is an observational prospective study in which patients affected by an adult onset Pompe disease will be followed-up during three years using different clinical, analytical and radiological tests in order to know which is the natural history of the disease and which is the impact that treatment with recombinant enzyme has in the progression of the disease. (clinicaltrials.gov)
The results were published in the Journal of Clinical Endocrinology and Metabolis by Dr. Johnny Deladoëy, a pediatric endocrinologist and researcher in metabolic and genetic diseases at CHU Sainte-Justine Research Center and an assistant professor of pediatrics and biochemistry at University of Montreal. (healthcanal.com)
Considering that the majority of clinical trials focused on traditional AD targets have failed to date, our group focused on the multifactorial aspect of the disease, and we hope our recent discovery will guide the development of AD therapeutics. (healthcanal.com)
The results provided new insight into brain activity underlying PD pathology and suggested that clinical improvement was achieved by disruption of a particular pattern from the variety of abnormal activity seen in the Parkinsonian brain. (medicalxpress.com)
Our aim was to evaluate whether brain development in late pregnancy can be predicted by fetal brain Doppler, head biometry and the clinical form of CHD at the time of diagnosis. (nih.gov)
Thus, the new study could help to improve diagnosis and predict the clinical course of the disease, including the severity of the final stages. (news-medical.net)
It will focus on obtaining insights into the interrelated problems of developmental and molecular biology and clinical diseases by i. generating MR probes that function as real-time in vivo physiological reporters (exogenous), ii. (chicagobiomedicalconsortium.org)
These metabolic models will be combined with enhanced MR imaging applicable to clinical field strengths of 3.0 Telsa. (chicagobiomedicalconsortium.org)
Good clinical outcome achieved when hematopoietic stem cell transplantation performed at the very early stage of the disease. (sigmaaldrich.com)

We generated a PD specific pattern (PDSP) based on a multivariate classification approach to differentiate between a PD and control group at a late disease stage, where the neurodegeneration is considered nearly complete. (nature.com)
In the central nervous system, mTOR inhibition has been shown to prevent neurodegeneration and protect brain functions in aging. (frontiersin.org)
Huntington's disease HD is caused by an expansion of the trinucleotide poly CAG tract located in exon 1 of the huntingtin Htt gene leading to progressive neurodegeneration in selected brain regions, and associated functional impairments in motor, cognitive, and psychiatric domains. (duhnnae.com)
Researchers have discovered that impairing a critical partnership between brain cells can lead to neurodegeneration. (medicalxpress.com)

Hepatic encephalopathy is probably not truly a degenerative brain disease, but it certainly causes confusion. (healthtap.com)
Any metabolic stress can lead to serious illness, with encephalopathy - a reduced level. (evidence.nhs.uk)
Wernicke's encephalopathy may be underdiagnosed because symptoms vary between people depending on the area of the brain most affected. (medicalnewstoday.com)
Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy. (ucsf.edu)
She is now applying these developments on chronic hepatic encephalopathy, a research area that she developed at CIBM ( https://actu.epfl.ch/news/when-liver-disease-affects-the-brain/ ), and on different collaborative projects with researchers from the five partner institutions of CIBM. (epfl.ch)
Jiang, W., Desjardins, P. and Butterworth, R.F. (2009b) Hypothermia attenuates oxidative/nitrosative stress, encephalopathy and brain edema in acute (ischemic) liver failure. (scirp.org)

The characteristic brain pathology in PD results in a pattern of abnormal cerebral glucose metabolism known as the PD-related pattern (PDRP). (rug.nl)

Therewere inconsistencies between the regions with increased metabolic activity and perfusionafter memantine treatment in drug-naïve AD patients, suggesting that brain metabolism mayincrease without a concurrent increase in blood perfusion. (jneuropsychiatry.org)
The mammalian brain depends upon glucose as its main source of energy, and tight regulation of glucose metabolism is critical for brain physiology. (nih.gov)
Here, we review recent advances in understanding how glucose metabolism sustains basic brain physiology. (nih.gov)
Glucose (Glc) is the main source of energy for the mammalian brain, (a) Specialized centers in the brain, including proopiomelanocortin (POMC) and agouti-related peptide (AgRP) neurons in the hypothalamus, sense central and peripheral glucose levels and regulate glucose metabolism through the vagal nerve as well as neuroendocrine signals. (nih.gov)
(b) Glucose supply to the brain is regulated by neurovascular coupling and may be modulated by metabolism-dependent and -independent mechanisms. (nih.gov)
those whose mother (but not father) had the disease also show reduced glucose metabolism and cognitive function , as well as elevated PIB uptake (a marker of amyloid) and brain atrophy . (plos.org)
A new study published in the journal Brain: a Journal of Neurology suggests a novel hypothesis as to how motor neuron disease (MND) develops as a result of abnormal cholesterol metabolism within nerve cells. (news-medical.net)
Belenky P, Bogan KL, Brenner C (2007) NAD+ metabolism in health and disease. (springer.com)
[6] These diseases, of which there are many subtypes, are known as inborn errors of metabolism . (wikipedia.org)
The recent discovery of mutations affecting metabolic enzymes such as succinate dehydrogenase, fumarate hydratase and isocitrate dehydrogenase provides genetic evidence that altered cellular metabolism can cause cancer. (keystonesymposia.org)

Treatment of rats with 3-NP altered the motor function, elevated oxidative stress and caused significant histopathological changes in the brain. (springer.com)
Oxidative stress induced by a high ammonia concentration could modify protein expression in the brain. (scirp.org)
Methylglyoxal-induced cytotoxicity in neonatal rat brain: a role for oxidative stress and MAP kinases. (sigmaaldrich.com)

Mahmoodabadi SZ, Alirezaie J, Babyn P, Kassner A, Widjaja E. Wavelets and fuzzy relational classifiers: a novel diffusion-weighted image analysis system for pediatric metabolic brain diseases. (sickkids.ca)
and guidance on limiting the use of ionizing radiation in evaluating pediatric diseases. (elsevier.com)
Research in pediatric thyroid diseases at CHU Sainte-Justine is supported by the Girafonds/CHU Sainte-Justine Foundation. (healthcanal.com)

Toxic metabolic encephalopathies (TMEs) present as an acute derangement in consciousness, cognition and behavior, and can be brought about by various triggers, including endocrine and metabolic disturbances, exogenous toxins, pain and infection. (nih.gov)
Andreassen OA, Dedeoglu A, Stanojevic V, Hughes DB, Browne SE, Leech CA, Ferrante RJ, Habener JF, Beal MF, Thomas MK (2002) Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression. (springer.com)

Brain cells are particularly sensitive to low levels of thiamine because it is required in many cellular pathways needed for normal brain activity. (medicalnewstoday.com)
The brain regulates the gut and its microbiota via neuroanatomic, immunological, and neuroendocrine-HPA axis pathways, communicating via neurotransmitters, neuropeptides, or microbial-derived products effecting gut microbiota. (springermedizin.de)

brain disease' implies a disorder involving the entire brain in an organic, cellular, or functional way -- not likely to be treated by surgery alone. (healthtap.com)
A genetic brain disorder is caused by a variation or a mutation in a gene. (medlineplus.gov)
Inflammatory bowel disease (IBD) is a gut disorder which is characterized by a recurrent and chronic gastrointestinal inflammation. (springermedizin.de)
Bilney B, Morris ME, Churchyard A, Chiu E, Georgiou-Karistianis N (2005) Evidence for a disorder of locomotor timing in Huntington's disease. (springer.com)
A metabolic disorder can happen when abnormal chemical reactions in the body alter the normal metabolic process . (wikipedia.org)
The symptoms expressed would vary with the type of metabolic disorder. (wikipedia.org)
If a metabolic disorder is not identified early, then it may be diagnosed later in life, when symptoms appear. (wikipedia.org)
In terms of pathophysiological/mechanism interactions, an abnormal gut microbioma can play a role in metabolic disorder related obesity. (wikipedia.org)
It is the third most common movement disorder after essential tremor and Parkinson disease. (prlog.org)

Patients with glycogen storage disease type III may become hypoglycaemic during a fast, the length of which varies widely between patients. (evidence.nhs.uk)
Glioblastoma multiforme, the most common malignant primary brain tumor of adults, is characterized by gains of chromosome 7 and losses of chromosome 10, which are seen in up to 80 to 90 percent of patients. (mhmedical.com)
PD patients' astrocytes manifest several hallmarks of the disease, these include: (1) increased production of alpha-synuclein, (2) increased reactivity upon inflammatory stimulation, (3) increased astrocytic Ca2+ levels, (4) mtDNA maintenance defects and (5) metabolomic changes. (eurekalert.org)
This program allows physicians to request permission from Amicus Therapeutics (Amicus) for treatment access to migalastat hydrochloride (HCl) for specific adult patients with Fabry disease. (clinicaltrials.gov)
We believe this is the first stu dy focusing on brain metabolic activity and perfusioni n the same drug-naïve moderate AD patients before and after memantine treatment. (jneuropsychiatry.org)
Many previous studies have measured perfusion and metabolic activity in AD patients treated with ChEIs. (jneuropsychiatry.org)
Re-Establishing Brain Networks in Patients with ESRD after Successful Kidney Transplantation. (rochester.edu)
A technique called deep brain stimulation (DBS) is sometimes used to improve motor symptoms in patients with advanced disease. (medicalxpress.com)
Nineteen patients (10 males, 9 females) with confirmed metabolic diagnoses were identified by systematic search of the genetics clinic database. (biomedsearch.com)

Previous reports have shown that this pattern is a useful biomarker of disease progression and of phenoconversion from iRBD to PD. (rug.nl)
We expect to find a biomarker useful to follow-up the progression of Pompe disease. (clinicaltrials.gov)
To know the natural progression of the disease regarding muscle atrophy measured using muscle MRI during a period of three years. (clinicaltrials.gov)
Now, a study published by Cell Press in the October 20 issue of the journal Neuron describes a new and more effective DBS paradigm that makes real-time adjustments in response to disease dynamics and progression and may be better for managing symptoms of advanced PD. (medicalxpress.com)
A dihydroflavonoid naringin extends the lifespan of C. elegans and delays the progression of aging-related diseases. (greenmedinfo.com)
Our data showed that hematopoietic stem cell transplantation performed at an advanced stage of the cerebral X- linked adrenoleukodystrophy would accelerate the progression of the disease. (sigmaaldrich.com)

The aim of this study was to use longitudinal small animal 18 F-FDG PET imaging to determine a PD specific glucose metabolic brain pattern for a PD rat model. (nature.com)
These alterations can be used as longitudinal markers for the disease. (elsevier.com)
Spatial regression analysis of serial DTI for subject-specific longitudinal changes of neurodegenerative disease. (rochester.edu)
In the current study, we characterized the zQ175 model housed in an academic laboratory under reversed dark-light cycle, including motor function, in vivo longitudinal structural MRI imaging for brain volume, MRS for striatal metabolites, neuropathology, as well as a panel of key disease marker proteins in the striatum at different ages. (duhnnae.com)

Starting with an illustrative case, this paper provides a neurologist's approach to the diagnosis, differential diagnosis and management of toxic metabolic encephalopathies. (nih.gov)

The discovery of detailed mechanisms leading to neuronal metabolic stress may be a key step that will allow the understanding how cognitive impairment develops in AD, thereby offering new avenues for effective disease prevention and therapeutic targeting. (frontiersin.org)
The understanding of molecular mechanisms driving AD pathogenesis may shed new light on novel targets for drug development and offer strategies for disease prevention. (frontiersin.org)
Imbalanced neurotransmitter signaling and pathologically heightened brain inflammatory cytokine signaling have been proposed as candidate mechanisms. (nih.gov)
11 When we are physiologically intact and healthy, intrinsic brain mechanisms typically allow us to recover spontaneously from uncomplicated single concussions within twenty-four to seventy-two hours. (westonaprice.org)
Thank you for your interest in spreading the word on Disease Models & Mechanisms. (biologists.org)
Message Body (Your Name) thought you would like to see the Disease Models & Mechanisms web site. (biologists.org)

Darocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, Rodríguez M, Sánchez B, Hyman BT, Gómez-Isla T (2011) Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice. (springer.com)
The purpose of this study is to develop small molecule radio-labeled probes of beta-amyloid, to be used with positron emission tomography (PET) for early detection and treatment monitoring of Alzheimer disease (AD). (clinicaltrials.gov)
We used new approaches to study the APP gene, which gives rise to amyloid plaques, a pathological hallmark of the disease," says Jerold Chun, M.D., Ph.D. , senior author of the paper and professor and senior vice president of Neuroscience Drug Discovery at SBP. (eurekalert.org)

MLD is caused by a deficiency of the enzyme arylsulfatase A. MLD is one of several lipid storage diseases, which results in the toxic build-up of fatty materials (lipids) in cells in the nervous system, liver, and kidneys. (clinicaltrials.gov)
Blasi P, Giovagnoli S, Schoubben A, Ricci M, Rossi C (2007) Solid lipid nanoparticles for targeted brain drug delivery. (springer.com)
A collaborative Stony Brook University research team has discovered a novel metabolic pathway of the lipid ceramide, which is involved in cell death. (medicalxpress.com)

Background and Objective: Previous studies revealed the association between serum Nterminal pro-brain natriuretic peptide (NT-proBNP) level and chronic kidney diseases (CKD) in general population. (eurekaselect.com)
Parents of children with chronic diseases often report increased level of stress and anxiety. (bioportfolio.com)
Later on, if the condition becomes long-term (your doctor will say it's chronic), you might notice brain fog, a confused and spacey feeling. (webmd.com)
Find out why we're experts in chronic disease. (prohealth.com)

Are metabolic enzymes the pathological trigger? (plos.org)

For example, blood clots that occur after traumatic brain injury(ie. (healthtap.com)
Geoff Manley, MD, PhD, is a leader in the study of traumatic brain injury. (ucsf.edu)
The problems and various other aspects of diagnosis of intra- and extra-axial brain tumors (more than 30,000 verified cases) as well as of cerebrovascular, infectious, demyelinating, degenerative and traumatic brain and spine lesions are discussed. (buecher.de)
When the film Concussion was released in late 2015, pundits noted that the topic of sports-related traumatic brain injuries (TBIs) had "gone Hollywood. (westonaprice.org)
Causes include genetics, traumatic brain injury, drug reaction, and numerous neurological or metabolic diseases. (prlog.org)

A recent alarming rise of neurodegenerative diseases in the developed world is one of the major medical issues affecting older adults. (mdpi.com)

In recent years, the role of PD driven aberrant discharge patterns of neuronal activity have emerged as pivotal in the pathophysiology of the disease, and there is an urgent need for an automatic and dynamic system that can continually adjust the stimulus in response to ongoing pathological changes ," explains Dr. Boris Rosin and Professor Hagai Bergman from The Hebrew University of Jerusalem. (medicalxpress.com)
Huntington's disease (HD) is characterized by cognitive and psychiatric impairment caused by neuronal degeneration in the brain. (springer.com)

Because species composition changes with disease state, some microbiome OTUs may serve as potential diagnostic indicators of disease. (nature.com)
Diagnostic testing must include a search for metabolic and infectious derangements. (nih.gov)
Brain magnetic resonance imaging is a useful diagnostic tool in the initial evaluation of children who appear to have CP. (biomedsearch.com)
The treatment for human disease at the earliest stages requires sensitive, quantitative, and non-destructive diagnostic monitoring methods. (chicagobiomedicalconsortium.org)
However, their diagnostic accuracy suffers when dealing with complex diseases particularly those that involve multiple domains in medicine. (wiley.com)

Magnetic resonance imaging (MRI) is one of the few technologies capable of localized, nondestructive metabolic characterization without ionizing radiation. (chicagobiomedicalconsortium.org)

Children with GLUT1 deficiency have an impaired glucose transport into the brain and glucose levels in CSF are low (hypoglychorrhachia). (evidence.nhs.uk)

Do Inflammation & Metabolic Disturbances Metastasize To The Brain? (psychu.org)
Additionally, it will discuss how innovative treatment approaches that target metabolic disturbances may have a positive impact on mental health. (psychu.org)
A series of deeply interrelated environmental and lifestyle problems-pesticide and chemical toxicity, exposure to heavy metals such as aluminum, poor gut health, overconsumption of processed foods, nutritional deficiencies (especially during the formative years), and insufficient access to sunlight-are setting into motion a perfect storm of events that are making our brains less resilient to shocks and disturbances of all types. (westonaprice.org)

This study was undertaken in order to investigate the impact of hyperammonemia, caused by thioacetmide (TAA) in rats, on brain cortex protein expression using 2D-DIGE, and analyzing its role in the pathogenesis of HE. (scirp.org)

This translational approach will result in metabolic imaging for monitoring the earliest stages of diseases, thereby stimulating the development of earlier, and therefore less expensive, interventions. (chicagobiomedicalconsortium.org)

Various magnetic resonance (MR) methods [i.e., imaging (MRI), angiography (MRA), and spectroscopy (MRS)], confocal microscopic imaging, and positron emission tomography (PET) provided in vivo metabolic and vascular measures. (frontiersin.org)
She is now developing new research lines at CIBM, being oriented towards new acquisition and quantification techniques for in vivo proton, phosphorous, carbon, nitrogen MRS and fast MRSI, diffusion weighted spectroscopy and brain macromolecules quantification. (epfl.ch)
1H-MR spectroscopy, performed in an affected 2-year-old girl with markedly delayed neuromotor development and typical supratentorial white-matter disease (WMD), showed an increase of choline and α-glutamate concentrations. (semanticscholar.org)

Altered spontaneous brain activity pattern in cognitively normal young adults carrying mutations of APP, presenilin-1/2 and APOE ε4. (rochester.edu)
Niemann-Pick type C (NPC) is a lysosomal storage disease associated with mutations in NPC1 and NPC2 genes. (wikipedia.org)

10(th) centile or abnormal metabolic profile in the frontal lobe. (nih.gov)

Brain Diseases, Metabolic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (sickkids.ca)

Sugar for the brain: the role of glucose in physiological and pathological brain function. (nih.gov)
Glucose enters the brain from the blood by crossing the BBB through glucose transporter 1 (GLUT1), and (c) glucose and other metabolites (e.g. lactate, Lac) are rapidly distributed through a highly coupled metabolic network of brain cells. (nih.gov)

In AD, evidence arising from in vitro , in vivo and neuropathology studies supports that such events occur throughout disease development and are linked to AβO neurotoxicity. (frontiersin.org)
However, the effects of mTOR inhibition for in vivo brain physiology remain largely unknown. (frontiersin.org)
Here, we review recent findings of in vivo metabolic and vascular measures using non-invasive, multimodal neuroimaging methods in rodent models for brain aging and AD. (frontiersin.org)
In 2006 she obtained her PhD degree in Localized Proton MRS and time domain quantification of cerebral metabolites at 7T and 4.7T at University Lyon 1, RMN Laboratory, Villeurbanne, France.In 2007, she joined, as a Scientist, the Laboratory for Functional and Metabolic Imaging at EPFL, where she implemented new acquisition and quantification techniques for in vivo nitrogen, proton and carbon MRS for preclinical studies. (epfl.ch)

Development of a new MS-based biomarker for the early and sensitive diagnosis of metachromatic leukodystrophy disease from plasma. (clinicaltrials.gov)

however, usually one or more of the symptoms develops later as the disease progresses. (wikipedia.org)
Both events occur early in the disease process, even before individuals show any symptoms of cognitive impairment. (plos.org)

Co-researcher Emma Baple says that the current research should help to achieve greater progress in the area of motor neuron disease, eventually leading to better diagnosis and treatment plans - a crucial need in this group of conditions that affects the quality of life of those affected very severely. (news-medical.net)

The astrocyte, one form of glial cell that comprises much of the background substance of the brain and spinal cord, is believed to give rise to a large category of primary brain tumors, the astrocytomas. (mhmedical.com)

The Centers for Disease Control and Prevention (CDC) categorizes concussions as a "mild" form of TBI but acknowledges that all TBIs disrupt normal brain function. (westonaprice.org)

Finally, the metabolic change in BA8/9/10 was inversely related to that in BA25 and showed relative increase with cognitive decline, suggesting that compensatory processes may occur in this dorso-medial prefrontal region. (inserm.fr)
These neoplasms can occur in all areas of the brain and spinal cord in children and adults. (mhmedical.com)
[7] Metabolic diseases can also occur when the liver or pancreas do not function properly. (wikipedia.org)

In fact, dysregulation of the GBMAx has been implicated in a variety of gastrointestinal and central nervous system (CNS) diseases. (springermedizin.de)
Demyelinating Diseases of the Central Nervous System. (buecher.de)

In the following sections, we review current evidence indicating that a newly defined form of metabolic stress leads the path to cognitive decline in AD. (frontiersin.org)

Metabolic imaging using both exogenous and endogenous agents is an essential technology for developing such early intervention strategies for humans. (chicagobiomedicalconsortium.org)

Failure in diagnosis of WE and thus treatment of the disease leads to death in approximately 20% of cases, while 75% are left with permanent brain damage associated with WKS. (wikipedia.org)
The strategic plan of the NIH emphasizes healthcare cost containment through earlier treatment of disease. (chicagobiomedicalconsortium.org)

Likewise, common diseases of modern adulthood, including obesity and diabetes mellitus, have been often regarded as AD risk factors ( De Felice, 2013 ). (frontiersin.org)
Concluded the scientists: "In view of these alarming results, it is plausible that obesity-associated metabolic disease…may be mechanistically linked to lower the academic and professional potential of adolescents. (pritikin.com)

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Neuropathological findings after bone marrow transplantation: an autopsy study of 180 cases. (1/159)

Bone marrow transplantation corrects osteopetrosis in the carbonic anhydrase II deficiency syndrome. (2/159)

Prognostic significance of cerebral metabolic abnormalities in patients with congestive heart failure. (3/159)

Regression of ventral striatum hypometabolism after calcium/calcitriol therapy in paroxysmal kinesigenic choreoathetosis due to idiopathic primary hypoparathyroidism. (4/159)

Non-hepatic hyperammonaemia: an important, potentially reversible cause of encephalopathy. (5/159)

Glucose and oxygen hypometabolism in aceruloplasminemia brains. (6/159)

Fat oxidation defect presenting with overwhelming ketonuria. (7/159)

Axonal damage: a key predictor of outcome in human CNS diseases. (8/159)

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Neuropathological findings after bone marrow transplantation: an autopsy study of 180 cases. (1/159)

Bone marrow transplantation corrects osteopetrosis in the carbonic anhydrase II deficiency syndrome. (2/159)

Prognostic significance of cerebral metabolic abnormalities in patients with congestive heart failure. (3/159)

Regression of ventral striatum hypometabolism after calcium/calcitriol therapy in paroxysmal kinesigenic choreoathetosis due to idiopathic primary hypoparathyroidism. (4/159)

Non-hepatic hyperammonaemia: an important, potentially reversible cause of encephalopathy. (5/159)

Glucose and oxygen hypometabolism in aceruloplasminemia brains. (6/159)

Fat oxidation defect presenting with overwhelming ketonuria. (7/159)

Axonal damage: a key predictor of outcome in human CNS diseases. (8/159)

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