A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
A calcium-binding protein that is 92 AA long, contains 2 EF-hand domains, and is concentrated mainly in GLIAL CELLS. Elevation of S100B levels in brain tissue correlates with a role in neurological disorders.
Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.
The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.
The circulation of blood through the BLOOD VESSELS of the BRAIN.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Elements of limited time intervals, contributing to particular results or situations.
Conditions characterized by persistent brain damage or dysfunction as sequelae of cranial trauma. This disorder may result from DIFFUSE AXONAL INJURY; INTRACRANIAL HEMORRHAGES; BRAIN EDEMA; and other conditions. Clinical features may include DEMENTIA; focal neurologic deficits; PERSISTENT VEGETATIVE STATE; AKINETIC MUTISM; or COMA.
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
Refers to animals in the period of time just after birth.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
Mechanical or anoxic trauma incurred by the infant during labor or delivery.
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
A circumscribed collection of purulent exudate in the brain, due to bacterial and other infections. The majority are caused by spread of infected material from a focus of suppuration elsewhere in the body, notably the PARANASAL SINUSES, middle ear (see EAR, MIDDLE); HEART (see also ENDOCARDITIS, BACTERIAL), and LUNG. Penetrating CRANIOCEREBRAL TRAUMA and NEUROSURGICAL PROCEDURES may also be associated with this condition. Clinical manifestations include HEADACHE; SEIZURES; focal neurologic deficits; and alterations of consciousness. (Adams et al., Principles of Neurology, 6th ed, pp712-6)
Vegetative state refers to the neurocognitive status of individuals with severe brain damage, in whom physiologic functions (sleep-wake cycles, autonomic control, and breathing) persist, but awareness (including all cognitive function and emotion) is abolished.
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
A hydro-lyase that catalyzes the dehydration of 2-phosphoglycerate to form PHOSPHOENOLPYRUVATE. Several different isoforms of this enzyme exist, each with its own tissue specificity.
A nonspecific term used to describe transient alterations or loss of consciousness following closed head injuries. The duration of UNCONSCIOUSNESS generally lasts a few seconds, but may persist for several hours. Concussions may be classified as mild, intermediate, and severe. Prolonged periods of unconsciousness (often defined as greater than 6 hours in duration) may be referred to as post-traumatic coma (COMA, POST-HEAD INJURY). (From Rowland, Merritt's Textbook of Neurology, 9th ed, p418)
Derived from TELENCEPHALON, cerebrum is composed of a right and a left hemisphere. Each contains an outer cerebral cortex and a subcortical basal ganglia. The cerebrum includes all parts within the skull except the MEDULLA OBLONGATA, the PONS, and the CEREBELLUM. Cerebral functions include sensorimotor, emotional, and intellectual activities.
Respiratory failure in the newborn. (Dorland, 27th ed)
Restoration of blood supply to tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. It is primarily a procedure for treating infarction or other ischemia, by enabling viable ischemic tissue to recover, thus limiting further necrosis. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing REPERFUSION INJURY.
Acquired or inborn metabolic diseases that produce brain dysfunction or damage. These include primary (i.e., disorders intrinsic to the brain) and secondary (i.e., extracranial) metabolic conditions that adversely affect cerebral function.
Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.
The measure of the level of heat of a human or animal.
Fractures of the skull which may result from penetrating or nonpenetrating head injuries or rarely BONE DISEASES (see also FRACTURES, SPONTANEOUS). Skull fractures may be classified by location (e.g., SKULL FRACTURE, BASILAR), radiographic appearance (e.g., linear), or based upon cranial integrity (e.g., SKULL FRACTURE, DEPRESSED).
Cognitive disorders characterized by an impaired ability to perceive the nature of objects or concepts through use of the sense organs. These include spatial neglect syndromes, where an individual does not attend to visual, auditory, or sensory stimuli presented from one side of the body.
A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The observable response an animal makes to any situation.
Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
An organophosphorus compound that inhibits cholinesterase. It causes seizures and has been used as a chemical warfare agent.
The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
An infant during the first month after birth.
A cognitive disorder marked by an impaired ability to comprehend or express language in its written or spoken form. This condition is caused by diseases which affect the language areas of the dominant hemisphere. Clinical features are used to classify the various subtypes of this condition. General categories include receptive, expressive, and mixed forms of aphasia.
An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
A mental disorder associated with chronic ethanol abuse (ALCOHOLISM) and nutritional deficiencies characterized by short term memory loss, confabulations, and disturbances of attention. (Adams et al., Principles of Neurology, 6th ed, p1139)
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Traumatic injuries to the cranium where the integrity of the skull is not compromised and no bone fragments or other objects penetrate the skull and dura mater. This frequently results in mechanical injury being transmitted to intracranial structures which may produce traumatic brain injuries, hemorrhage, or cranial nerve injury. (From Rowland, Merritt's Textbook of Neurology, 9th ed, p417)
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A relatively common sequela of blunt head injury, characterized by a global disruption of axons throughout the brain. Associated clinical features may include NEUROBEHAVIORAL MANIFESTATIONS; PERSISTENT VEGETATIVE STATE; DEMENTIA; and other disorders.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
Deficient oxygenation of FETAL BLOOD.
The arterial blood vessels supplying the CEREBRUM.
A genotoxicological technique for measuring DNA damage in an individual cell using single-cell gel electrophoresis. Cell DNA fragments assume a "comet with tail" formation on electrophoresis and are detected with an image analysis system. Alkaline assay conditions facilitate sensitive detection of single-strand damage.
The coordination of a sensory or ideational (cognitive) process and a motor activity.
Veins draining the cerebrum.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Penetrating and nonpenetrating traumatic injuries to an extracranial or intracranial blood vessel that supplies the brain. This includes the CAROTID ARTERIES; VERTEBRAL ARTERIES; MENINGEAL ARTERIES; CEREBRAL ARTERIES; veins, and venous sinuses.
Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).
Assessment of sensory and motor responses and reflexes that is used to determine impairment of the nervous system.
Benzenesulfonate derivative used as a systemic hemostatic.
An amino acid that, as the D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors (RECEPTORS, NMDA).
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Intellectual or mental process whereby an organism obtains knowledge.
Dominance of one cerebral hemisphere over the other in cerebral functions.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
Pressure within the cranial cavity. It is influenced by brain mass, the circulatory system, CSF dynamics, and skull rigidity.
Elongated gray mass of the neostriatum located adjacent to the lateral ventricle of the brain.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Central nervous system vasculitis that is associated with SYSTEMIC LUPUS ERYTHEMATOSUS. Clinical manifestations may include DEMENTIA; SEIZURES; CRANIAL NERVE DISEASES; HEMIPARESIS; BLINDNESS; DYSPHASIA; and other neurological disorders.
Upper central part of the cerebral hemisphere. It is located posterior to central sulcus, anterior to the OCCIPITAL LOBE, and superior to the TEMPORAL LOBES.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Failure of a professional person, a physician or lawyer, to render proper services through reprehensible ignorance or negligence or through criminal intent, especially when injury or loss follows. (Random House Unabridged Dictionary, 2d ed)
Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
Therapy for MOVEMENT DISORDERS, especially PARKINSON DISEASE, that applies electricity via stereotactic implantation of ELECTRODES in specific areas of the BRAIN such as the THALAMUS. The electrodes are attached to a neurostimulator placed subcutaneously.
Abnormally low BODY TEMPERATURE that is intentionally induced in warm-blooded animals by artificial means. In humans, mild or moderate hypothermia has been used to reduce tissue damages, particularly after cardiac or spinal cord injuries and during subsequent surgeries.
Recurrent seizures causally related to CRANIOCEREBRAL TRAUMA. Seizure onset may be immediate but is typically delayed for several days after the injury and may not occur for up to two years. The majority of seizures have a focal onset that correlates clinically with the site of brain injury. Cerebral cortex injuries caused by a penetrating foreign object (CRANIOCEREBRAL TRAUMA, PENETRATING) are more likely than closed head injuries (HEAD INJURIES, CLOSED) to be associated with epilepsy. Concussive convulsions are nonepileptic phenomena that occur immediately after head injury and are characterized by tonic and clonic movements. (From Rev Neurol 1998 Feb;26(150):256-261; Sports Med 1998 Feb;25(2):131-6)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
Paired bodies containing mostly GRAY MATTER and forming part of the lateral wall of the THIRD VENTRICLE of the brain.
Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and cognitive disorders. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1)
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Neural tracts connecting one part of the nervous system with another.
A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
Learning the correct route through a maze to obtain reinforcement. It is used for human or animal populations. (Thesaurus of Psychological Index Terms, 6th ed)
The production of a dense fibrous network of neuroglia; includes astrocytosis, which is a proliferation of astrocytes in the area of a degenerative lesion.
Injections into the cerebral ventricles.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Severe or complete loss of motor function on one side of the body. This condition is usually caused by BRAIN DISEASES that are localized to the cerebral hemisphere opposite to the side of weakness. Less frequently, BRAIN STEM lesions; cervical SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; and other conditions may manifest as hemiplegia. The term hemiparesis (see PARESIS) refers to mild to moderate weakness involving one side of the body.
Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)
Partial or complete loss of vision in one half of the visual field(s) of one or both eyes. Subtypes include altitudinal hemianopsia, characterized by a visual defect above or below the horizontal meridian of the visual field. Homonymous hemianopsia refers to a visual defect that affects both eyes equally, and occurs either to the left or right of the midline of the visual field. Binasal hemianopsia consists of loss of vision in the nasal hemifields of both eyes. Bitemporal hemianopsia is the bilateral loss of vision in the temporal fields. Quadrantanopsia refers to loss of vision in one quarter of the visual field in one or both eyes.
A surgical specialty concerned with the treatment of diseases and disorders of the brain, spinal cord, and peripheral and sympathetic nervous system.
The anterior of the three primitive cerebral vesicles of the embryonic brain arising from the NEURAL TUBE. It subdivides to form DIENCEPHALON and TELENCEPHALON. (Stedmans Medical Dictionary, 27th ed)
Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A group of cognitive disorders characterized by the inability to perform previously learned skills that cannot be attributed to deficits of motor or sensory function. The two major subtypes of this condition are ideomotor (see APRAXIA, IDEOMOTOR) and ideational apraxia, which refers to loss of the ability to mentally formulate the processes involved with performing an action. For example, dressing apraxia may result from an inability to mentally formulate the act of placing clothes on the body. Apraxias are generally associated with lesions of the dominant PARIETAL LOBE and supramarginal gyrus. (From Adams et al., Principles of Neurology, 6th ed, pp56-7)
An interleukin-1 receptor subtype that is involved in signaling cellular responses to INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The binding of this receptor to its ligand causes its favorable interaction with INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN and the formation of an activated receptor complex.
The largest and most lateral of the BASAL GANGLIA lying between the lateral medullary lamina of the GLOBUS PALLIDUS and the EXTERNAL CAPSULE. It is part of the neostriatum and forms part of the LENTIFORM NUCLEUS along with the GLOBUS PALLIDUS.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.
Neurologic disorders caused by exposure to toxic substances through ingestion, injection, cutaneous application, or other method. This includes conditions caused by biologic, chemical, and pharmaceutical agents.
A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
The awareness of the spatial properties of objects; includes physical space.
Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
A family of tricyclic hydrocarbons whose members include many of the commonly used tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC).
A language dysfunction characterized by the inability to name people and objects that are correctly perceived. The individual is able to describe the object in question, but cannot provide the name. This condition is associated with lesions of the dominant hemisphere involving the language areas, in particular the TEMPORAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, p484)
The largest of the cerebral arteries. It trifurcates into temporal, frontal, and parietal branches supplying blood to most of the parenchyma of these lobes in the CEREBRAL CORTEX. These are the areas involved in motor, sensory, and speech activities.
The process by which chemical compounds provide protection to cells against harmful agents.
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
Relatively complete absence of oxygen in one or more tissues.
The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)
A syndrome of abnormally low BLOOD GLUCOSE level. Clinical hypoglycemia has diverse etiologies. Severe hypoglycemia eventually lead to glucose deprivation of the CENTRAL NERVOUS SYSTEM resulting in HUNGER; SWEATING; PARESTHESIA; impaired mental function; SEIZURES; COMA; and even DEATH.
An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.
A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.
A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
A plant genus of the family ROSACEAE. Members contain sanguiin.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
A scale that assesses the response to stimuli in patients with craniocerebral injuries. The parameters are eye opening, motor response, and verbal response.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
A technique in which tissue is rendered resistant to the deleterious effects of prolonged ISCHEMIA and REPERFUSION by prior exposure to brief, repeated periods of vascular occlusion. (Am J Physiol 1995 May;268(5 Pt 2):H2063-7, Abstract)
Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
The time from the onset of a stimulus until a response is observed.
(2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
The observable response of a man or animal to a situation.
Loss of the ability to comprehend the meaning or recognize the importance of various forms of stimulation that cannot be attributed to impairment of a primary sensory modality. Tactile agnosia is characterized by an inability to perceive the shape and nature of an object by touch alone, despite unimpaired sensation to light touch, position, and other primary sensory modalities.
The measurement of an organ in volume, mass, or heaviness.
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Abnormally high BLOOD GLUCOSE level.
Wave-like oscillations of electric potential between parts of the brain recorded by EEG.
An acquired cognitive disorder characterized by inattentiveness and the inability to form short term memories. This disorder is frequently associated with chronic ALCOHOLISM; but it may also result from dietary deficiencies; CRANIOCEREBRAL TRAUMA; NEOPLASMS; CEREBROVASCULAR DISORDERS; ENCEPHALITIS; EPILEPSY; and other conditions. (Adams et al., Principles of Neurology, 6th ed, p1139)
Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Performance of complex motor acts.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)
The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.

Unilateral neglect and disambiguation of the Necker cube. (1/706)

Three groups of patients (right brain-damaged patients with or without left neglect, and left brain-damaged patients) and a group of healthy subjects, matched for age and educational level to the three groups of patients, were asked to report which of the two frontal surfaces of Necker cubes oriented in four different ways looked, at first sight, nearer to the viewer. The extent to which, and the way in which, disambiguation of the apparent perspective of Necker cubes occurred was found to vary across the four orientations and to be different in left-neglect patients compared with subjects of the other three groups. With normal subjects, the disambiguating factor is suggested to be a disposition to perceive the upper surface, which is nearly orthogonal to the frontal plane, as external to the cube. This would result from a navigation of the observer's spatial attention towards its target along a particular path that is altered in patients suffering from left neglect. It is suggested that comparison of the paths followed by the attentional vectors of normal subjects and left-neglect patients is potentially fruitful for a better understanding of the brain's normal mechanisms of spatial attention and of unresolved issues concerning the perception of the Necker cube.  (+info)

Space representation in unilateral spatial neglect. (2/706)

Patients with unilateral brain lesions were given a task requiring exploration of space with the hand in order to assess the visual dependency of unilateral spatial neglect. The task was carried out both without visual control and under visual control. Performances were compared with that of normal subjects. Results were :(1) patients with right brain damage with no visual field defect demonstrated left-sided neglect only when the exploration was not controlled visually; (2) patients with left and right brain damage with visual field defect demonstrated contralateral neglect only when the exploration was under visual guidance. The performance of the patients with right brain damage without visual field defect in not clearly understood. The other results suggest that inner spatial representation remains intact in most cases of spatial neglect. The role of parietal lobe damage in the development of this visually induced phenomenon is hypothesised. The dominant position of vision among the senses is indicated.  (+info)

Predictive value of plasma and cerebrospinal fluid tumour necrosis factor-alpha and interleukin-1 beta concentrations on outcome of full term infants with hypoxic-ischaemic encephalopathy. (3/706)

AIM: To determine the predictive value of plasma and cerebrospinal fluid (CSF) tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) concentrations on the outcome of hypoxic-ischaemic encephalopathy (HIE) in full term infants. METHODS: Thirty term infants with HIE were included in the study. HIE was classified according to the criteria of Sarnat and Sarnat. Blood and CSF were obtained within the first 24 hours of life and stored until assay. Five infants died soon after hypoxic insult. Neurological examinations and Denver Developmental Screening Test (DDST) were performed at 12 months in the survivors. RESULTS: At the age of 12 months neurological examination and DDST showed that 11 infants were normal; 14 had abnormal neurological findings and/or an abnormal DDST result. Eleven normal infants were classified as group 1 and 19 infants (14 with abnormal neurological findings and/or an abnormal DDST and five who died) as group 2. CSF IL-1 beta and TNF-alpha concentrations in group 2 were significantly higher than those in group 1. Plasma IL-1 beta and TNF-alpha concentrations were not significantly different between the two groups. IL-1 beta, but not TNF-alpha concentrations, in group 2 were even higher than those in group 1, although non-survivors were excluded from group 2. When the patients were evaluated according to the stages of Sarnat, the difference in the three groups was again significant. Patients whose CSF samples were taken within 6 hours of the hypoxic insult had higher IL-1 beta and TNF-alpha concentrations than the patients whose samples were taken after 6 hours. CONCLUSIONS: Both cytokines probably contribute to the damage sustained by the central nervous system after hypoxic insult. IL-1 beta seems to be a better predictor of HIE than TNF-alpha.  (+info)

Stroke in patients with acute coronary syndromes: incidence and outcomes in the platelet glycoprotein IIb/IIIa in unstable angina. Receptor suppression using integrilin therapy (PURSUIT) trial. The PURSUIT Investigators. (4/706)

BACKGROUND: The incidence of stroke in patients with acute coronary syndromes has not been clearly defined because few trials in this patient population have been large enough to provide stable estimates of stroke rates. METHODS AND RESULTS: We studied the 10 948 patients with acute coronary syndromes without persistent ST-segment elevation who were randomly assigned to placebo or the platelet glycoprotein IIb/IIIa receptor inhibitor eptifibatide in the Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) trial to determine stroke rates, stroke types, clinical outcomes in patients with stroke, and independent baseline clinical predictors for nonhemorrhagic stroke. Stroke occurred in 79 (0.7%) patients, with 66 (0.6%) nonhemorrhagic, 6 intracranial hemorrhages, 3 cerebral infarctions with hemorrhagic conversion, and 4 of uncertain cause. There were no differences in stroke rates between patients who received placebo and those assigned high-dose eptifibatide (odds ratios and 95% confidence intervals 0.82 [0.59, 1.14] and 0.70 [0.49, 0.99], respectively). Of the 79 patients with stroke, 17 (22%) died within 30 days, and another 26 (32%) were disabled by hospital discharge or 30 days, whichever came first. Higher heart rate was the most important baseline clinical predictor of nonhemorrhagic stroke, followed by older age, prior anterior myocardial infarction, prior stroke or transient ischemic attack, and diabetes mellitus. These factors were used to develop a simple scoring nomogram that can predict the risk of nonhemorrhagic stroke. CONCLUSIONS: Stroke was an uncommon event in patients with acute coronary syndromes in the PURSUIT trial. These strokes are, however, associated with substantial morbidity and mortality rates. The majority of strokes were of nonhemorrhagic causes. Eptifibatide was not associated with an increase in intracranial hemorrhage, and no significant effect on nonhemorrhagic stroke was observed. We developed a useful nomogram for assigning baseline nonhemorrhagic stroke risk in this patient population.  (+info)

Postural characteristics of diabetic neuropathy. (5/706)

OBJECTIVE: To explore the posturographic correlates of diabetic neuropathy by comparing the performances of three groups of diabetic patients (severe, moderate, and absent neuropathy) with those of normal subjects and four clinical control groups. RESEARCH DESIGN AND METHODS: Using the Interactive Balance System (Tetrax, Ramat Gan, Israel), based on the assessment of the interaction of vertical pressure fluctuations on four independent platforms, one for each heel and toe part, respectively, posturographic examinations were given to 28 diabetic patients (8 with severe, 12 with moderate, and 8 with no peripheral neuropathy), 30 normal control subjects, and a clinical control group of 52 patients (14 with stage II Parkinson's disease, 13 with brain damage, 7 with whiplash, and 19 with peripheral vestibular pathology). The following posturographic parameters were evaluated; 1) general stability; 2) Fourier analysis showing patterns of sway intensity within eight frequency bands between 0.1 and 3 Hz; 3) weight distribution; 4) synchronization of sway; and 5) performance patterns for eight positions, requiring closure of eyes and standing on an elastic surface, as well as left, right, back, and downward head turns. RESULTS: For positions with closed eyes, diabetic patients with severe and moderate neuropathy were significantly less stable than normal subjects and diabetic patients without neuropathy, but diabetic patients with severe and moderate neuropathy turned out to be as equally unstable as clinical control subjects. However, for sway intensity within the band of 0.5 to 1.00 Hz on positions with lateral head turn with occluded vision, neuropathic diabetic patients performed significantly worse than did both normal and clinical control subjects. The same posturographic parameter also differed significantly between normal subjects and diabetic patients without neuropathy. CONCLUSIONS: As reported in previous studies, general instability in diabetic neuropathy is not a sufficiently characteristic correlate of the syndrome. On the other hand, spectral analysis of sway on stressful positions involving head turning appears to differentiate diabetic neuropathy from other disorders involving postural disturbances.  (+info)

Language related brain potentials in patients with cortical and subcortical left hemisphere lesions. (6/706)

The role of the basal ganglia in language processing is currently a matter of discussion. Therefore, patients with left frontal cortical and subcortical lesions involving the basal ganglia as well as normal controls were tested in a language comprehension paradigm. Semantically incorrect, syntactically incorrect and correct sentences were presented auditorily. Subjects were required to listen to the sentences and to judge whether the sentence heard was correct or not. Event-related potentials and reaction times were recorded while subjects heard the sentences. Three different components correlated with different language processes were considered: the so-called N400 assumed to reflect processes of semantic integration; the early left anterior negativity hypothesized to reflect processes of initial syntactic structure building; and a late positivity (P600) taken to reflect second-pass processes including re-analysis and repair. Normal participants showed the expected N400 component for semantically incorrect sentences and an early anterior negativity followed by a P600 for syntactically incorrect sentences. Patients with left frontal cortical lesions displayed an attenuated N400 component in the semantic condition. In the syntactic condition only a late positivity was observed. Patients with lesions of the basal ganglia, in contrast, showed an N400 to semantic violations and an early anterior negativity as well as a P600 to syntactic violations, comparable to normal controls. Under the assumption that the early anterior negativity reflects automatic first-pass parsing processes and the P600 component more controlled second-pass parsing processes, the present results suggest that the left frontal cortex might support early parsing processes, and that specific regions of the basal ganglia, in contrast, may not be crucial for early parsing processes during sentence comprehension.  (+info)

Early neurobehavioral outcome after stroke is related to release of neurobiochemical markers of brain damage. (7/706)

BACKGROUND AND PURPOSE: The study aimed to investigate the predictive value of neurobiochemical markers of brain damage (protein S-100B and neuron-specific enolase [NSE]) with respect to early neurobehavioral outcome after stroke. METHODS: We investigated 58 patients with completed stroke who were admitted to the stroke unit of the Department of Neurology at Magdeburg University. Serial venous blood samples were taken after admission and during the first 4 days, and protein S-100B and NSE were analyzed by the use of immunoluminometric assays. In all patients, lesion topography and vascular supply were analyzed and volume of infarcted brain areas was calculated. The neurological status was evaluated by a standardized neurological examination and the National Institutes of Health Stroke Scale (NIHSS) on admission, at days 1 and 4 on the stroke unit, at day 10, and at discharge from the hospital. Comprehensive neuropsychological examinations were performed in all patients with first-ever stroke event and supratentorial brain infarctions. Functional outcome was measured with the Barthel score at discharge from the hospital. RESULTS: NSE and protein S-100B concentrations were significantly correlated with both volume of infarcted brain areas and NIHSS scores. Patients with an adverse neurological outcome had a significantly higher and significantly longer release of both markers. Neuropsychological impairment was associated with higher protein S-100B release, but this did not reach statistical significance. CONCLUSIONS: Serum concentrations and kinetics of protein S-100B and NSE have a high predictive value for early neurobehavioral outcome after acute stroke. Protein S-100B concentrations at days 2 to 4 after acute stroke may provide valuable information for both neurological status and functional impairment at discharge from the acute care hospital.  (+info)

Cognitive rehabilitation for schizophrenia: problems, prospects, and strategies. (8/706)

Increasing awareness of the importance of neurocognitive impairments in schizophrenia has fostered considerable interest in the prospects for cognitive rehabilitation. Nevertheless, optimism has outpaced progress. We first review recent literature on the central assumptions that underlie cognitive rehabilitation, including the hypothesis that cognitive deficits play a central role in social disability and other problems schizophrenia patients experience in daily living, and that these impairments must be rectified if we are to achieve effective rehabilitation. We next discuss developments in knowledge about the neurobiology of schizophrenia that bear on the potential for cognitive rehabilitation and the selection of appropriate targets for intervention. Third, we propose a new research strategy for investigating cognitive functioning in schizophrenia and for examining the relationship of cognitive deficits to role functioning in the community: examining patients who have good vocational outcomes in order to identify strengths or compensatory factors that compensate for core deficits. We present new data that lend support to our proposed approach. We next discuss putative limits to cognitive rehabilitation based on data documenting cognitive deficits in healthy siblings and parents. Finally, we briefly describe an interim rehabilitation strategy that minimizes the load on cognitive processes rather than attempting to improve cognitive functioning.  (+info)

Some common causes of chronic brain damage include:

1. Traumatic brain injury (TBI): A blow to the head or other traumatic injury that causes the brain to bounce or twist inside the skull, leading to damage to brain cells and tissues.
2. Stroke or cerebral vasculature disorders: A loss of blood flow to the brain due to a blockage or rupture of blood vessels, leading to cell death and tissue damage.
3. Infections such as meningitis or encephalitis: Inflammation of the brain and its membranes caused by viral or bacterial infections, which can lead to damage to brain cells and tissues.
4. Chronic exposure to toxins, such as pesticides or heavy metals: Prolonged exposure to these substances can damage brain cells and tissues over time.
5. Neurodegenerative diseases, such as Alzheimer's disease or Parkinson's disease: These conditions are characterized by the progressive loss of brain cells and tissue, leading to cognitive decline and other symptoms.

The effects of chronic brain damage can vary depending on the location and severity of the damage. Some common effects include:

1. Cognitive impairments: Difficulty with memory, attention, problem-solving, and other cognitive functions.
2. Emotional and behavioral changes: Depression, anxiety, irritability, and mood swings.
3. Physical symptoms: Weakness or paralysis on one side of the body, difficulty with balance and coordination, and changes in sensation or perception.
4. Communication difficulties: Slurred speech, difficulty finding the right words, and trouble understanding spoken language.
5. Social and occupational impairments: Difficulty with daily activities, social interactions, and work-related tasks.

The good news is that there are several strategies that can help mitigate the effects of chronic brain damage. These include:

1. Physical exercise: Regular physical activity has been shown to promote brain health and reduce the risk of cognitive decline.
2. Cognitive stimulation: Engaging in mentally challenging activities, such as reading, puzzles, or learning a new skill, can help build cognitive reserve and reduce the risk of cognitive decline.
3. Social engagement: Building and maintaining social connections has been shown to promote brain health and reduce the risk of cognitive decline.
4. Stress management: Chronic stress can exacerbate brain damage, so finding ways to manage stress, such as through meditation or exercise, is important.
5. Proper nutrition: Eating a diet rich in fruits, vegetables, and omega-3 fatty acids can help support brain health and reduce the risk of cognitive decline.
6. Medication and therapy: In some cases, medication or therapy may be necessary to manage the symptoms of chronic brain damage.
7. Neuroplasticity-based interventions: Techniques that promote neuroplasticity, such as non-invasive brain stimulation, can help improve cognitive function and reduce the risk of cognitive decline.

It's important to note that these strategies may not reverse chronic brain damage, but they can help mitigate its effects and improve overall brain health. If you suspect that you or someone you know may be experiencing chronic brain damage, it is important to seek medical attention as soon as possible. Early diagnosis and treatment can help reduce the risk of long-term cognitive decline and improve quality of life.

There are several different types of brain injuries that can occur, including:

1. Concussions: A concussion is a type of mild traumatic brain injury that occurs when the brain is jolted or shaken, often due to a blow to the head.
2. Contusions: A contusion is a bruise on the brain that can occur when the brain is struck by an object, such as during a car accident.
3. Coup-contrecoup injuries: This type of injury occurs when the brain is injured as a result of the force of the body striking another object, such as during a fall.
4. Penetrating injuries: A penetrating injury occurs when an object pierces the brain, such as during a gunshot wound or stab injury.
5. Blast injuries: This type of injury occurs when the brain is exposed to a sudden and explosive force, such as during a bombing.

The symptoms of brain injuries can vary depending on the severity of the injury and the location of the damage in the brain. Some common symptoms include:

* Headaches
* Dizziness or loss of balance
* Confusion or disorientation
* Memory loss or difficulty with concentration
* Slurred speech or difficulty with communication
* Vision problems, such as blurred vision or double vision
* Sleep disturbances
* Mood changes, such as irritability or depression
* Personality changes
* Difficulty with coordination and balance

In some cases, brain injuries can be treated with medication, physical therapy, and other forms of rehabilitation. However, in more severe cases, the damage may be permanent and long-lasting. It is important to seek medical attention immediately if symptoms persist or worsen over time.

The term ischemia refers to the reduction of blood flow, and it is often used interchangeably with the term stroke. However, not all strokes are caused by ischemia, as some can be caused by other factors such as bleeding in the brain. Ischemic stroke accounts for about 87% of all strokes.

There are different types of brain ischemia, including:

1. Cerebral ischemia: This refers to the reduction of blood flow to the cerebrum, which is the largest part of the brain and responsible for higher cognitive functions such as thought, emotion, and voluntary movement.
2. Cerebellar ischemia: This refers to the reduction of blood flow to the cerebellum, which is responsible for coordinating and regulating movement, balance, and posture.
3. Brainstem ischemia: This refers to the reduction of blood flow to the brainstem, which is responsible for controlling many of the body's automatic functions such as breathing, heart rate, and blood pressure.
4. Territorial ischemia: This refers to the reduction of blood flow to a specific area of the brain, often caused by a blockage in a blood vessel.
5. Global ischemia: This refers to the reduction of blood flow to the entire brain, which can be caused by a cardiac arrest or other systemic conditions.

The symptoms of brain ischemia can vary depending on the location and severity of the condition, but may include:

1. Weakness or paralysis of the face, arm, or leg on one side of the body
2. Difficulty speaking or understanding speech
3. Sudden vision loss or double vision
4. Dizziness or loss of balance
5. Confusion or difficulty with memory
6. Seizures
7. Slurred speech or inability to speak
8. Numbness or tingling sensations in the face, arm, or leg
9. Vision changes, such as blurred vision or loss of peripheral vision
10. Difficulty with coordination and balance.

It is important to seek medical attention immediately if you experience any of these symptoms, as brain ischemia can cause permanent damage or death if left untreated.

Brain hypoxia is a serious medical condition that requires prompt treatment to prevent long-term damage and improve outcomes for patients. Treatment options may include oxygen therapy, medications to improve blood flow to the brain, and surgery to remove any blockages or obstructions in blood vessels.

Brain neoplasms can arise from various types of cells in the brain, including glial cells (such as astrocytes and oligodendrocytes), neurons, and vascular tissues. The symptoms of brain neoplasms vary depending on their size, location, and type, but may include headaches, seizures, weakness or numbness in the limbs, and changes in personality or cognitive function.

There are several different types of brain neoplasms, including:

1. Meningiomas: These are benign tumors that arise from the meninges, the thin layers of tissue that cover the brain and spinal cord.
2. Gliomas: These are malignant tumors that arise from glial cells in the brain. The most common type of glioma is a glioblastoma, which is aggressive and hard to treat.
3. Pineal parenchymal tumors: These are rare tumors that arise in the pineal gland, a small endocrine gland in the brain.
4. Craniopharyngiomas: These are benign tumors that arise from the epithelial cells of the pituitary gland and the hypothalamus.
5. Medulloblastomas: These are malignant tumors that arise in the cerebellum, specifically in the medulla oblongata. They are most common in children.
6. Acoustic neurinomas: These are benign tumors that arise on the nerve that connects the inner ear to the brain.
7. Oligodendrogliomas: These are malignant tumors that arise from oligodendrocytes, the cells that produce the fatty substance called myelin that insulates nerve fibers.
8. Lymphomas: These are cancers of the immune system that can arise in the brain and spinal cord. The most common type of lymphoma in the CNS is primary central nervous system (CNS) lymphoma, which is usually a type of B-cell non-Hodgkin lymphoma.
9. Metastatic tumors: These are tumors that have spread to the brain from another part of the body. The most common types of metastatic tumors in the CNS are breast cancer, lung cancer, and melanoma.

These are just a few examples of the many types of brain and spinal cord tumors that can occur. Each type of tumor has its own unique characteristics, such as its location, size, growth rate, and biological behavior. These factors can help doctors determine the best course of treatment for each patient.

The effects of hypoxia-ischemia on the brain can vary depending on the severity and duration of the insult, but may include:

* Cellular damage and death
* Inflammation and oxidative stress
* Neurotransmitter imbalances
* Blood-brain barrier disruption
* White matter degeneration

The long-term consequences of hypoxia-ischemia, brain may include cognitive impairments such as memory loss, attention deficits, and language difficulties. Behavioral changes, such as depression, anxiety, and mood swings, may also occur. In severe cases, the condition can lead to permanent vegetative state or death.

The diagnosis of hypoxia-ischemia, brain is based on a combination of clinical evaluation, laboratory tests, and imaging studies such as CT or MRI scans. Treatment options may include supportive care, medications, and rehabilitation therapies to address cognitive and behavioral impairments. In some cases, surgical interventions may be necessary to relieve pressure or restore blood flow to the affected areas.

Overall, hypoxia-ischemia, brain is a serious medical condition that requires prompt recognition and appropriate treatment to minimize long-term cognitive and functional impairments.

The word "edema" comes from the Greek word "oidema", meaning swelling.

Some common types of brain diseases include:

1. Neurodegenerative diseases: These are progressive conditions that damage or kill brain cells over time, leading to memory loss, cognitive decline, and movement disorders. Examples include Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS).
2. Stroke: This occurs when blood flow to the brain is interrupted, leading to cell death and potential long-term disability.
3. Traumatic brain injury (TBI): This refers to any type of head injury that causes damage to the brain, such as concussions, contusions, or penetrating wounds.
4. Infections: Viral, bacterial, and fungal infections can all affect the brain, leading to a range of symptoms including fever, seizures, and meningitis.
5. Tumors: Brain tumors can be benign or malignant and can cause a variety of symptoms depending on their location and size.
6. Cerebrovascular diseases: These conditions affect the blood vessels of the brain, leading to conditions such as aneurysms, arteriovenous malformations (AVMs), and Moyamoya disease.
7. Neurodevelopmental disorders: These are conditions that affect the development of the brain and nervous system, such as autism spectrum disorder, ADHD, and intellectual disability.
8. Sleep disorders: Conditions such as insomnia, narcolepsy, and sleep apnea can all have a significant impact on brain function.
9. Psychiatric disorders: Mental health conditions such as depression, anxiety, and schizophrenia can affect the brain and its functioning.
10. Neurodegenerative with brain iron accumulation: Conditions such as Parkinson's disease, Alzheimer's disease, and Huntington's disease are characterized by the accumulation of abnormal proteins and other substances in the brain, leading to progressive loss of brain function over time.

It is important to note that this is not an exhaustive list and there may be other conditions or factors that can affect the brain and its functioning. Additionally, many of these conditions can have a significant impact on a person's quality of life, and it is important to seek medical attention if symptoms persist or worsen over time.

1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.

2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.

3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.

4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.

5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.

6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.

7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.

8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.

9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.

10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.

Infarction Middle Cerebral Artery (MCA) is a type of ischemic stroke that occurs when there is an obstruction in the middle cerebral artery. This artery supplies blood to the temporal lobe of the brain, which controls many important functions such as memory, language, and spatial reasoning. When this artery becomes blocked or ruptured, it can cause a lack of blood supply to the affected areas resulting in tissue death (infarction).

The symptoms of an MCA infarction can vary depending on the location and severity of the blockage. Some common symptoms include weakness or paralysis on one side of the body, difficulty with speech and language, memory loss, confusion, vision problems, and difficulty with coordination and balance. Patients may also experience sudden severe headache, nausea, vomiting, and fever.

The diagnosis of MCA infarction is based on a combination of clinical examination, imaging studies such as CT or MRI scans, and laboratory tests. Imaging studies can help to identify the location and severity of the blockage, while laboratory tests may be used to rule out other conditions that may cause similar symptoms.

Treatment for MCA infarction depends on the underlying cause of the blockage or rupture. In some cases, medications such as thrombolytics may be given to dissolve blood clots and restore blood flow to the affected areas. Surgery may also be required to remove any blockages or repair damaged blood vessels. Other interventions such as endovascular procedures or brain bypass surgery may also be used to restore blood flow.

In summary, middle cerebral artery infarction is a type of stroke that occurs when the blood supply to the brain is blocked or interrupted, leading to damage to the brain tissue. It can cause a range of symptoms including weakness or paralysis on one side of the body, difficulty with speech and language, memory loss, confusion, vision problems, and difficulty with coordination and balance. The diagnosis is based on a combination of clinical examination, imaging studies, and laboratory tests. Treatment options include medications, surgery, endovascular procedures, or brain bypass surgery.

Cerebral infarction can result in a range of symptoms, including sudden weakness or numbness in the face, arm, or leg on one side of the body, difficulty speaking or understanding speech, sudden vision loss, dizziness, and confusion. Depending on the location and severity of the infarction, it can lead to long-term disability or even death.

There are several types of cerebral infarction, including:

1. Ischemic stroke: This is the most common type of cerebral infarction, accounting for around 87% of all cases. It occurs when a blood clot blocks the flow of blood to the brain, leading to cell death and tissue damage.
2. Hemorrhagic stroke: This type of cerebral infarction occurs when a blood vessel in the brain ruptures, leading to bleeding and cell death.
3. Lacunar infarction: This type of cerebral infarction affects the deep structures of the brain, particularly the basal ganglia, and is often caused by small blockages or stenosis (narrowing) in the blood vessels.
4. Territorial infarction: This type of cerebral infarction occurs when there is a complete blockage of a blood vessel that supplies a specific area of the brain, leading to cell death and tissue damage in that area.

Diagnosis of cerebral infarction typically involves a combination of physical examination, medical history, and imaging tests such as CT or MRI scans. Treatment options vary depending on the cause and location of the infarction, but may include medication to dissolve blood clots, surgery to remove blockages, or supportive care to manage symptoms and prevent complications.

Types: There are several types of brain infarction, including:

1. Cerebral infarction: This type of infarction occurs when there is a blockage or obstruction in the blood vessels that supply the cerebrum, which is the largest part of the brain.
2. Cerebellar infarction: This type of infarction occurs when there is a blockage or obstruction in the blood vessels that supply the cerebellum, which is located at the base of the brain.
3. Brain stem infarction: This type of infarction occurs when there is a blockage or obstruction in the blood vessels that supply the brain stem, which is the part of the brain that controls vital functions such as breathing, heart rate, and blood pressure.

Symptoms: The symptoms of brain infarction can vary depending on the location and size of the affected area, but common symptoms include:

1. Sudden weakness or numbness in the face, arm, or leg
2. Sudden confusion or trouble speaking or understanding speech
3. Sudden difficulty seeing or blindness
4. Sudden difficulty walking or loss of balance
5. Sudden severe headache
6. Difficulty with coordination and movement
7. Slurred speech
8. Vision changes
9. Seizures

Diagnosis: Brain infarction is typically diagnosed using a combination of physical examination, medical history, and imaging tests such as CT or MRI scans. Other diagnostic tests may include blood tests to check for signs of infection or blood clotting abnormalities, and an electroencephalogram (EEG) to measure the electrical activity of the brain.

Treatment: The treatment of brain infarction depends on the underlying cause, but common treatments include:

1. Medications: To control symptoms such as high blood pressure, seizures, and swelling in the brain.
2. Endovascular therapy: A minimally invasive procedure to open or remove blockages in the blood vessels.
3. Surgery: To relieve pressure on the brain or repair damaged blood vessels.
4. Rehabilitation: To help regain lost function and improve quality of life.

Prognosis: The prognosis for brain infarction depends on the location and size of the affected area, as well as the promptness and effectiveness of treatment. In general, the earlier treatment is received, the better the outcome. However, some individuals may experience long-term or permanent disability, or even death.

Some common symptoms of chronic brain injury include:

* Memory loss or difficulty with concentration
* Dizziness or balance problems
* Headaches or migraines
* Mood changes, such as depression or irritability
* Sleep disturbances
* Fatigue or lethargy

Chronic brain injury can be caused by a variety of factors, including:

* Repeated blows to the head, such as from playing contact sports or experiencing physical abuse
* Traumatic injuries, such as those sustained in car accidents or falls
* Infections, such as meningitis or encephalitis
* Stroke or other cardiovascular problems
* Poor nutrition or exposure to toxins

Treatment for chronic brain injury typically involves a team of healthcare professionals, including neurologists, psychiatrists, physical therapists, and occupational therapists. Treatment may include medication, physical therapy, cognitive rehabilitation, and lifestyle changes.

Prognosis for chronic brain injury varies depending on the severity of the injury and the promptness and effectiveness of treatment. Some people may experience significant improvement with treatment, while others may have ongoing symptoms and disabilities.

Example sentence: "The patient experienced a transient ischemic attack, which was caused by a temporary blockage in one of the blood vessels in their brain."

Synonyms: TIA, mini-stroke.

Some common types of birth injuries include:

1. Brain damage: This can occur due to a lack of oxygen to the baby's brain during delivery, resulting in conditions such as cerebral palsy or hypoxic ischemic encephalopathy (HIE).
2. Nerve damage: This can result from prolonged labor, use of forceps or vacuum extraction, or improper handling of the baby during delivery, leading to conditions such as brachial plexus injuries or Erb's palsy.
3. Fractures: These can occur due to improper use of forceps or vacuum extraction, or from the baby being dropped or handled roughly during delivery.
4. Cutaneous injuries: These can result from rough handling or excessive pressure during delivery, leading to conditions such as caput succedaneum (swelling of the scalp) or cephalohematoma (bleeding under the skin of the head).
5. Infections: These can occur if the baby is exposed to bacteria during delivery, leading to conditions such as sepsis or meningitis.
6. Respiratory distress syndrome: This can occur if the baby does not breathe properly after birth, resulting in difficulty breathing and low oxygen levels.
7. Shoulder dystocia: This occurs when the baby's shoulder becomes stuck during delivery, leading to injury or damage to the baby's shoulder or neck.
8. Umbilical cord prolapse: This occurs when the umbilical cord comes out of the birth canal before the baby, leading to compression or strangulation of the cord and potentially causing injury to the baby.
9. Meconium aspiration: This occurs when the baby inhales a mixture of meconium (bowel movement) and amniotic fluid during delivery, leading to respiratory distress and other complications.
10. Brachial plexus injuries: These occur when the nerves in the baby's neck and shoulder are damaged during delivery, leading to weakness or paralysis of the arm and hand.

It is important to note that not all birth injuries can be prevented, but proper medical care and attention during pregnancy, labor, and delivery can help minimize the risk of complications. If you suspect that your baby has been injured during delivery, it is important to seek prompt medical attention to ensure proper diagnosis and treatment.

There are many different types of seizures, each with its own unique set of symptoms. Some common types of seizures include:

1. Generalized seizures: These seizures affect both sides of the brain and can cause a range of symptoms, including convulsions, loss of consciousness, and muscle stiffness.
2. Focal seizures: These seizures affect only one part of the brain and can cause more specific symptoms, such as weakness or numbness in a limb, or changes in sensation or vision.
3. Tonic-clonic seizures: These seizures are also known as grand mal seizures and can cause convulsions, loss of consciousness, and muscle stiffness.
4. Absence seizures: These seizures are also known as petit mal seizures and can cause a brief loss of consciousness or staring spell.
5. Myoclonic seizures: These seizures can cause sudden, brief muscle jerks or twitches.
6. Atonic seizures: These seizures can cause a sudden loss of muscle tone, which can lead to falls or drops.
7. Lennox-Gastaut syndrome: This is a rare and severe form of epilepsy that can cause multiple types of seizures, including tonic, atonic, and myoclonic seizures.

Seizures can be diagnosed through a combination of medical history, physical examination, and diagnostic tests such as electroencephalography (EEG) or imaging studies. Treatment for seizures usually involves anticonvulsant medications, but in some cases, surgery or other interventions may be necessary.

Overall, seizures are a complex and multifaceted symptom that can have a significant impact on an individual's quality of life. It is important to seek medical attention if you or someone you know is experiencing seizures, as early diagnosis and treatment can help to improve outcomes and reduce the risk of complications.

1. Ischemic stroke: This is the most common type of stroke, accounting for about 87% of all strokes. It occurs when a blood vessel in the brain becomes blocked, reducing blood flow to the brain.
2. Hemorrhagic stroke: This type of stroke occurs when a blood vessel in the brain ruptures, causing bleeding in the brain. High blood pressure, aneurysms, and blood vessel malformations can all cause hemorrhagic strokes.
3. Transient ischemic attack (TIA): Also known as a "mini-stroke," a TIA is a temporary interruption of blood flow to the brain that lasts for a short period of time, usually less than 24 hours. TIAs are often a warning sign for a future stroke and should be taken seriously.

Stroke can cause a wide range of symptoms depending on the location and severity of the damage to the brain. Some common symptoms include:

* Weakness or numbness in the face, arm, or leg
* Difficulty speaking or understanding speech
* Sudden vision loss or double vision
* Dizziness, loss of balance, or sudden falls
* Severe headache
* Confusion, disorientation, or difficulty with memory

Stroke is a leading cause of long-term disability and can have a significant impact on the quality of life for survivors. However, with prompt medical treatment and rehabilitation, many people are able to recover some or all of their lost functions and lead active lives.

The medical community has made significant progress in understanding stroke and developing effective treatments. Some of the most important advances include:

* Development of clot-busting drugs and mechanical thrombectomy devices to treat ischemic strokes
* Improved imaging techniques, such as CT and MRI scans, to diagnose stroke and determine its cause
* Advances in surgical techniques for hemorrhagic stroke
* Development of new medications to prevent blood clots and reduce the risk of stroke

Despite these advances, stroke remains a significant public health problem. According to the American Heart Association, stroke is the fifth leading cause of death in the United States and the leading cause of long-term disability. In 2017, there were over 795,000 strokes in the United States alone.

There are several risk factors for stroke that can be controlled or modified. These include:

* High blood pressure
* Diabetes mellitus
* High cholesterol levels
* Smoking
* Obesity
* Lack of physical activity
* Poor diet

In addition to these modifiable risk factors, there are also several non-modifiable risk factors for stroke, such as age (stroke risk increases with age), family history of stroke, and previous stroke or transient ischemic attack (TIA).

The medical community has made significant progress in understanding the causes and risk factors for stroke, as well as developing effective treatments and prevention strategies. However, more research is needed to improve outcomes for stroke survivors and reduce the overall burden of this disease.

The symptoms of a brain abscess can vary depending on the location and size of the abscess, but may include:

* Headache
* Fever
* Confusion or disorientation
* Seizures
* Weakness or numbness in the arms or legs
* Vision problems
* Speech difficulties

If a brain abscess is suspected, a doctor will typically perform a physical examination and order imaging tests such as CT or MRI scans to confirm the diagnosis. Treatment usually involves antibiotics to treat the underlying infection, as well as surgery to drain the abscess and remove any infected tissue. In severe cases, hospitalization may be necessary to monitor and treat the patient.

With prompt and appropriate treatment, most people with a brain abscess can recover fully or almost fully, but in some cases, the condition can result in long-term complications such as memory loss, cognitive impairment, or personality changes. In rare instances, a brain abscess can be fatal if not treated promptly and properly.

The diagnosis of PVS is made by a team of healthcare professionals, including neurosurgeons, neurologists, and rehabilitation specialists. The diagnosis is based on a combination of clinical examination and medical imaging studies, such as electroencephalograms (EEGs) and functional magnetic resonance imaging (fMRI).

There are three main criteria for diagnosing PVS:

1. Lack of awareness: The patient is unable to open their eyes or respond purposefully to stimuli.
2. Lack of purposeful movement: The patient is unable to move voluntarily, except for possibly some reflex movements.
3. Abnormal sleep-wake cycle: The patient exhibits a persistent vegetative state sleep-wake cycle, characterized by periods of sleep and wakefulness that are not consistent with normal sleep patterns.

Treatment for PVS is focused on supporting the patient's basic needs, such as breathing and nutrition, and managing any underlying medical conditions. However, there is no cure for PVS, and the condition is often permanent. Some patients may eventually recover some cognitive and behavioral functions over time, but many will remain in a state of persistent vegetative state for the rest of their lives.

In summary, the definition of persistent vegetative state (PVS) in the medical field refers to a severe loss of cognitive and behavioral function, resulting from traumatic brain injury or other causes, characterized by a lack of awareness, purposeful movement, and abnormal sleep-wake cycle. The diagnosis is made by a team of healthcare professionals, and treatment focuses on supporting the patient's basic needs and managing any underlying medical conditions.

There are many different types of nerve degeneration that can occur in various parts of the body, including:

1. Alzheimer's disease: A progressive neurological disorder that affects memory and cognitive function, leading to degeneration of brain cells.
2. Parkinson's disease: A neurodegenerative disorder that affects movement and balance, caused by the loss of dopamine-producing neurons in the brain.
3. Amyotrophic lateral sclerosis (ALS): A progressive neurological disease that affects nerve cells in the brain and spinal cord, leading to muscle weakness, paralysis, and eventually death.
4. Multiple sclerosis: An autoimmune disease that affects the central nervous system, causing inflammation and damage to nerve fibers.
5. Diabetic neuropathy: A complication of diabetes that can cause damage to nerves in the hands and feet, leading to pain, numbness, and weakness.
6. Guillain-Barré syndrome: An autoimmune disorder that can cause inflammation and damage to nerve fibers, leading to muscle weakness and paralysis.
7. Chronic inflammatory demyelinating polyneuropathy (CIDP): An autoimmune disorder that can cause inflammation and damage to nerve fibers, leading to muscle weakness and numbness.

The causes of nerve degeneration are not always known or fully understood, but some possible causes include:

1. Genetics: Some types of nerve degeneration may be inherited from one's parents.
2. Aging: As we age, our nerve cells can become damaged or degenerate, leading to a decline in cognitive and physical function.
3. Injury or trauma: Physical injury or trauma to the nervous system can cause nerve damage and degeneration.
4. Infections: Certain infections, such as viral or bacterial infections, can cause nerve damage and degeneration.
5. Autoimmune disorders: Conditions such as Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy (CIDP) are caused by the immune system attacking and damaging nerve cells.
6. Toxins: Exposure to certain toxins, such as heavy metals or pesticides, can damage and degenerate nerve cells.
7. Poor nutrition: A diet that is deficient in essential nutrients, such as vitamin B12 or other B vitamins, can lead to nerve damage and degeneration.
8. Alcoholism: Long-term alcohol abuse can cause nerve damage and degeneration due to the toxic effects of alcohol on nerve cells.
9. Drug use: Certain drugs, such as chemotherapy drugs and antiviral medications, can damage and degenerate nerve cells.
10. Aging: As we age, our nerve cells can deteriorate and become less functional, leading to a range of cognitive and motor symptoms.

It's important to note that in some cases, nerve damage and degeneration may be irreversible, but there are often strategies that can help manage symptoms and improve quality of life. If you suspect you have nerve damage or degeneration, it's important to seek medical attention as soon as possible to receive an accurate diagnosis and appropriate treatment.

Concussions are often referred to as "mild" because they do not typically cause severe, long-term damage like more severe forms of traumatic brain injury. However, concussions can still have a significant impact on a person's cognitive, emotional, and physical functioning, and can take several weeks or even months to fully recover from.

Some common symptoms of a concussion include:

* Headache
* Dizziness or loss of balance
* Confusion or disorientation
* Nausea and vomiting
* Sensitivity to light and noise
* Memory loss or difficulty concentrating
* Mood changes, such as irritability or depression

Concussions can be caused by a variety of events, including:

* Sports injuries, such as falling and hitting your head during a game or practice
* Car accidents or other forms of trauma where the head is jolted or shaken violently
* Slips and falls, where the head hits the ground or a hard surface
* Physical abuse or assault, where the head is struck with an object or by another person.

If you suspect that you or someone else has suffered a concussion, it is important to seek medical attention as soon as possible. A healthcare professional can evaluate the symptoms and perform tests to determine the severity of the injury. Treatment for a concussion typically involves rest and avoiding activities that may exacerbate the injury, such as sports or heavy physical activity. In some cases, medication may be prescribed to help manage symptoms such as pain or anxiety.

In summary, a brain concussion is a form of mild traumatic brain injury that can cause a range of symptoms and can take several weeks or months to fully recover from. If you suspect that you or someone else has suffered a concussion, it is important to seek medical attention as soon as possible to ensure proper diagnosis and treatment.

This can happen for various reasons, such as:

1. Prolonged labor or difficult delivery
2. Umbilical cord compression or knotting
3. Fetal distress or heart rate abnormalities during delivery
4. Maternal hypertension or pre-eclampsia
5. Placental abruption or placental insufficiency
6. Infection in the mother or baby during pregnancy or delivery
7. Drug or alcohol exposure during pregnancy
8. Maternal trauma or shock during delivery
9. Fetal growth restriction or small for gestational age
10. Congenital anomalies or birth defects

The symptoms of asphyxia neonatorum can vary depending on the severity and duration of the oxygen deprivation, but may include:

1. Cyanosis (blue skin color)
2. Apnea (pauses in breathing)
3. Bradycardia (slow heart rate)
4. Hypotonia (low muscle tone)
5. Poor reflexes
6. Seizures or convulsions
7. Gradual decline in muscle tone and organ function over time
8. Increased risk of infection or sepsis
9. Neurological damage, including cerebral palsy or cognitive impairment
10. Mortality (death)

Asphyxia neonatorum is a medical emergency that requires immediate attention and treatment. Treatment may include oxygen therapy, mechanical ventilation, and other supportive care to help the baby recover from the asphyxial event. In severe cases, asphyxia neonatorum can lead to long-term disabilities or death, so it is crucial to identify and treat the underlying causes promptly and effectively.

These disorders can cause a range of symptoms including cognitive impairment, confusion, memory loss, seizures, and changes in behavior and mood. Treatment options for brain disease metabolic disorders vary depending on the specific condition and may include medication, lifestyle changes, and other interventions such as surgery or rehabilitation therapy.

Examples of brain diseases, metabolic include:

* Hypoglycemia (low blood sugar)
* Hyperglycemia (high blood sugar)
* Diabetes mellitus (type 1 and type 2)
* Metabolic stroke
* Traumatic brain injury
* Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.

It is important to note that while these conditions are considered metabolic disorders, they can also have a significant impact on other aspects of an individual's life, including their mood, behavior, and cognitive functioning. Therefore, it is important to seek medical attention if symptoms persist or worsen over time.

Encephalitis can cause a range of symptoms, including fever, headache, confusion, seizures, and loss of consciousness. In severe cases, encephalitis can lead to brain damage, coma, and even death.

The diagnosis of encephalitis is based on a combination of clinical signs, laboratory tests, and imaging studies. Laboratory tests may include blood tests to detect the presence of antibodies or antigens specific to the causative agent, as well as cerebrospinal fluid (CSF) analysis to look for inflammatory markers and/or bacteria or viruses in the CSF. Imaging studies, such as CT or MRI scans, may be used to visualize the brain and identify any areas of damage or inflammation.

Treatment of encephalitis typically involves supportive care, such as intravenous fluids, oxygen therapy, and medication to manage fever and pain. Antiviral or antibacterial drugs may be used to target the specific causative agent, if identified. In severe cases, hospitalization in an intensive care unit (ICU) may be necessary to monitor and manage the patient's condition.

Prevention of encephalitis includes vaccination against certain viruses that can cause the condition, such as herpes simplex virus and Japanese encephalitis virus. Additionally, avoiding exposure to mosquitoes and other insects that can transmit viruses or bacteria that cause encephalitis, as well as practicing good hygiene and sanitation, can help reduce the risk of infection.

Overall, encephalitis is a serious and potentially life-threatening condition that requires prompt medical attention for proper diagnosis and treatment. With appropriate care, many patients with encephalitis can recover fully or partially, but some may experience long-term neurological complications or disability.

There are several types of atrophy that can occur in different parts of the body. For example:

1. Muscular atrophy: This occurs when muscles weaken and shrink due to disuse or injury.
2. Neuronal atrophy: This occurs when nerve cells degenerate, leading to a loss of cognitive function and memory.
3. Cardiac atrophy: This occurs when the heart muscle weakens and becomes less efficient, leading to decreased cardiac output.
4. Atrophic gastritis: This is a type of stomach inflammation that can lead to the wasting away of the stomach lining.
5. Atrophy of the testes: This occurs when the testes shrink due to a lack of use or disorder, leading to decreased fertility.

Atrophy can be diagnosed through various medical tests and imaging studies, such as MRI or CT scans. Treatment for atrophy depends on the underlying cause and may involve physical therapy, medication, or surgery. In some cases, atrophy can be prevented or reversed with proper treatment and care.

In summary, atrophy is a degenerative process that can occur in various parts of the body due to injury, disease, or disuse. It can lead to a loss of function and decreased quality of life, but with proper diagnosis and treatment, it may be possible to prevent or reverse some forms of atrophy.

In medical terminology, coma is defined as a state of prolonged unconsciousness that lasts for more than 24 hours and is characterized by a lack of responsiveness to stimuli, including pain, light, sound, or touch. Coma can be caused by a variety of factors, such as:

1. Traumatic brain injury: Coma can result from a severe head injury that causes damage to the brain.
2. Stroke: A stroke can cause coma if it affects a large part of the brain.
3. Infections: Bacterial or viral infections can spread to the brain and cause coma.
4. Poisoning: Toxic substances, such as drugs or chemicals, can cause coma by damaging the brain.
5. Hypoxia: Lack of oxygen to the brain can cause coma.
6. Hypoglycemia: Low blood sugar can cause coma.
7. Metabolic disorders: Certain metabolic disorders, such as diabetic ketoacidosis or hypothyroidism, can cause coma.
8. Electrolyte imbalance: An imbalance of electrolytes, such as sodium or potassium, can cause coma.
9. Chronic conditions: Certain chronic conditions, such as brain tumors or degenerative diseases like Alzheimer's or Parkinson's, can cause coma over time.

It is important to note that a coma is different from a vegetative state, which is characterized by awakening and opening one's eyes but lacking any meaningful response to stimuli. A comatose patient may also exhibit automatic responses, such as breathing or reacting to pain, but they are not aware of their surroundings or able to communicate.

The diagnosis of coma is typically made by a neurologist based on the patient's medical history, physical examination, and results of diagnostic tests such as electroencephalography (EEG) or imaging studies like computed tomography (CT) or magnetic resonance imaging (MRI). Treatment of coma depends on the underlying cause and may include supportive care, medication, or surgical intervention.

Symptoms of cerebral hemorrhage may include sudden severe headache, confusion, seizures, weakness or numbness in the face or limbs, and loss of consciousness. The condition is diagnosed through a combination of physical examination, imaging tests such as CT or MRI scans, and laboratory tests to determine the cause of the bleeding.

Treatment for cerebral hemorrhage depends on the location and severity of the bleeding, as well as the underlying cause. Medications may be used to control symptoms such as high blood pressure or seizures, while surgery may be necessary to repair the ruptured blood vessel or relieve pressure on the brain. In some cases, the condition may be fatal, and immediate medical attention is essential to prevent long-term damage or death.

Some of the most common complications associated with cerebral hemorrhage include:

1. Rebleeding: There is a risk of rebleeding after the initial hemorrhage, which can lead to further brain damage and increased risk of death.
2. Hydrocephalus: Excess cerebrospinal fluid can accumulate in the brain, leading to increased intracranial pressure and potentially life-threatening complications.
3. Brain edema: Swelling of the brain tissue can occur due to the bleeding, leading to increased intracranial pressure and potentially life-threatening complications.
4. Seizures: Cerebral hemorrhage can cause seizures, which can be a sign of a more severe injury.
5. Cognitive and motor deficits: Depending on the location and severity of the bleeding, cerebral hemorrhage can result in long-term cognitive and motor deficits.
6. Vision loss: Cerebral hemorrhage can cause vision loss or blindness due to damage to the visual cortex.
7. Communication difficulties: Cerebral hemorrhage can cause difficulty with speech and language processing, leading to communication difficulties.
8. Behavioral changes: Depending on the location and severity of the bleeding, cerebral hemorrhage can result in behavioral changes, such as irritability, agitation, or apathy.
9. Infection: Cerebral hemorrhage can increase the risk of infection, particularly if the hemorrhage is caused by a ruptured aneurysm or arteriovenous malformation (AVM).
10. Death: Cerebral hemorrhage can be fatal, particularly if the bleeding is severe or if there are underlying medical conditions that compromise the patient's ability to tolerate the injury.

In medical terms, craniocerebral trauma is defined as any injury that affects the skull, brain, or both, as a result of an external force. This can include fractures of the skull, intracranial hemorrhages (bleeding inside the skull), and diffuse axonal injuries (DAI), which are tears in the fibers of the brain.

Craniocerebral trauma can be classified into two main categories: closed head injury and open head injury. Closed head injury occurs when the skull does not fracture, but the brain is still affected by the impact, such as from whiplash or shaking. Open head injury, on the other hand, involves a fracture of the skull, which can cause the brain to be exposed to the outside environment and increase the risk of infection.

Treatment for craniocerebral trauma depends on the severity of the injury and may include observation, medication, surgery, or a combination of these. In severe cases, craniocerebral trauma can lead to long-term cognitive, emotional, and physical impairments, and may require ongoing rehabilitation and support.

There are several different types of skull fractures, including:

1. Linear skull fractures: These are fractures that occur in a straight line and do not involve the brain.
2. Depressed skull fractures: These are fractures that cause the bone to be pushed inward, creating a depression in the skull.
3. Comminuted skull fractures: These are fractures that involve multiple pieces of bone breaking off and fragmenting.
4. Basilar skull fractures: These are fractures that occur at the base of the skull and can involve the brainstem or cranial nerves.
5. Cerebral edema: This is a condition in which fluid accumulates in the brain as a result of a head injury or other traumatic event.
6. Epidural hematoma: This is a collection of blood between the skull and the dura mater, which is the membrane that covers the brain.
7. Subdural hematoma: This is a collection of blood between the dura mater and the brain.
8. Intracerebral hematoma: This is a collection of blood within the brain tissue.

Skull fractures can be diagnosed using a variety of imaging tests, such as X-rays, CT scans, or MRI scans. Treatment for skull fractures may involve observation, medication, or surgery, depending on the severity of the injury and any other complications that may have arisen.

Complications of skull fractures can include:

1. Cerebral edema
2. Epidural hematoma
3. Subdural hematoma
4. Intracerebral hematoma
5. Brain contusion
6. Skull base fractures
7. Facial trauma
8. Sinus fractures
9. Orbital blowout fractures
10. Meningitis or sepsis.

It is important to seek medical attention immediately if any of the following symptoms are present:

1. Severe headache
2. Confusion or disorientation
3. Slurred speech or difficulty speaking
4. Weakness or numbness in the arms or legs
5. Vision changes, such as double vision or blurred vision
6. Difficulty with balance or coordination
7. Seizures or convulsions
8. Fever
9. Stiff neck
10. Loss of consciousness or coma.

Some common types of perceptual disorders include:

1. Visual perceptual disorders: These disorders affect an individual's ability to interpret and make sense of visual information from the environment. They can result in difficulties with recognizing objects, perceiving depth and distance, and tracking movement.
2. Auditory perceptual disorders: These disorders affect an individual's ability to interpret and make sense of sound. They can result in difficulties with hearing and understanding speech, as well as distinguishing between different sounds.
3. Tactile perceptual disorders: These disorders affect an individual's ability to interpret and make sense of touch. They can result in difficulties with recognizing objects through touch, as well as interpreting tactile sensations such as pain, temperature, and texture.
4. Olfactory perceptual disorders: These disorders affect an individual's ability to interpret and make sense of smells. They can result in difficulties with identifying different odors and distinguishing between them.
5. Gustatory perceptual disorders: These disorders affect an individual's ability to interpret and make sense of tastes. They can result in difficulties with identifying different flavors and distinguishing between them.
6. Balance and equilibrium disorders: These disorders affect an individual's ability to maintain balance and equilibrium. They can result in difficulties with standing, walking, and maintaining posture.

Perceptual disorders can have a significant impact on an individual's daily life, making it difficult to perform everyday tasks and activities. Treatment for perceptual disorders often involves a combination of sensory therapy, behavioral therapy, and assistive technologies. The goal of treatment is to help the individual compensate for any impairments in sensory processing and improve their ability to function in daily life.

Types of Cognition Disorders: There are several types of cognitive disorders that affect different aspects of cognitive functioning. Some common types include:

1. Attention Deficit Hyperactivity Disorder (ADHD): Characterized by symptoms of inattention, hyperactivity, and impulsivity.
2. Traumatic Brain Injury (TBI): Caused by a blow or jolt to the head that disrupts brain function, resulting in cognitive, emotional, and behavioral changes.
3. Alzheimer's Disease: A progressive neurodegenerative disorder characterized by memory loss, confusion, and difficulty with communication.
4. Stroke: A condition where blood flow to the brain is interrupted, leading to cognitive impairment and other symptoms.
5. Parkinson's Disease: A neurodegenerative disorder that affects movement, balance, and cognition.
6. Huntington's Disease: An inherited disorder that causes progressive damage to the brain, leading to cognitive decline and other symptoms.
7. Frontotemporal Dementia (FTD): A group of neurodegenerative disorders characterized by changes in personality, behavior, and language.
8. Post-Traumatic Stress Disorder (PTSD): A condition that develops after a traumatic event, characterized by symptoms such as anxiety, avoidance, and hypervigilance.
9. Mild Cognitive Impairment (MCI): A condition characterized by memory loss and other cognitive symptoms that are more severe than normal age-related changes but not severe enough to interfere with daily life.

Causes and Risk Factors: The causes of cognition disorders can vary depending on the specific disorder, but some common risk factors include:

1. Genetics: Many cognitive disorders have a genetic component, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
2. Age: As people age, their risk of developing cognitive disorders increases, such as Alzheimer's disease, vascular dementia, and frontotemporal dementia.
3. Lifestyle factors: Factors such as physical inactivity, smoking, and poor diet can increase the risk of cognitive decline and dementia.
4. Traumatic brain injury: A severe blow to the head or a traumatic brain injury can increase the risk of developing cognitive disorders, such as chronic traumatic encephalopathy (CTE).
5. Infections: Certain infections, such as meningitis and encephalitis, can cause cognitive disorders if they damage the brain tissue.
6. Stroke or other cardiovascular conditions: A stroke or other cardiovascular conditions can cause cognitive disorders by damaging the blood vessels in the brain.
7. Chronic substance abuse: Long-term use of drugs or alcohol can damage the brain and increase the risk of cognitive disorders, such as dementia.
8. Sleep disorders: Sleep disorders, such as sleep apnea, can increase the risk of cognitive disorders, such as dementia.
9. Depression and anxiety: Mental health conditions, such as depression and anxiety, can increase the risk of cognitive decline and dementia.
10. Environmental factors: Exposure to certain environmental toxins, such as pesticides and heavy metals, has been linked to an increased risk of cognitive disorders.

It's important to note that not everyone with these risk factors will develop a cognitive disorder, and some people without any known risk factors can still develop a cognitive disorder. If you have concerns about your cognitive health, it's important to speak with a healthcare professional for proper evaluation and diagnosis.

There are several types of aphasia, including:

1. Broca's aphasia: Characterized by difficulty speaking in complete sentences and using correct grammar.
2. Wernicke's aphasia: Characterized by difficulty understanding spoken language and speaking in complete sentences.
3. Global aphasia: Characterized by a severe impairment of all language abilities.
4. Primary progressive aphasia: A rare form of aphasia that is caused by neurodegeneration and worsens over time.

Treatment for aphasia typically involves speech and language therapy, which can help individuals with aphasia improve their communication skills and regain some of their language abilities. Other forms of therapy, such as cognitive training and physical therapy, may also be helpful.

It's important to note that while aphasia can significantly impact an individual's quality of life, it does not affect their intelligence or cognitive abilities. With appropriate treatment and support, individuals with aphasia can continue to lead fulfilling lives and communicate effectively with others.

Definition: Meningitis, pneumococcal, is an inflammatory disease caused by Streptococcus pneumoniae (pneumococcus) that affects the protective membranes (meninges) covering the brain and spinal cord, leading to a range of symptoms including fever, headache, vomiting, and altered mental status. It can be a severe and potentially life-threatening infection, particularly in certain patient populations such as children under 5 years old, older adults, and those with underlying medical conditions.

Epidemiology: Pneumococcal meningitis is relatively uncommon, but it remains an important public health concern, particularly in developed countries. According to the Centers for Disease Control and Prevention (CDC), there are approximately 350 cases of pneumococcal meningitis reported each year in the United States, resulting in about 10% of all cases of bacterial meningitis.

Risk Factors: Several risk factors have been identified for developing pneumococcal meningitis, including:

1. Age: Children under 5 years old and older adults are at increased risk.
2. Underlying medical conditions: Patients with conditions such as sickle cell disease, HIV/AIDS, and chronic lung disease are more likely to develop pneumococcal meningitis.
3. Weakened immune system: Those with compromised immune systems, such as those taking immunosuppressive medications or who have undergone organ transplants, are at higher risk.
4. Recent exposure to someone with pneumococcal disease: Close contact with someone who has recently been diagnosed with pneumococcal disease can increase the risk of developing the infection.

Clinical Presentation: Symptoms of pneumococcal meningitis can vary depending on the age of the patient, but common presentations include:

1. Fever
2. Headache
3. Vomiting
4. Altered mental status (in infants and young children) or confusion (in older adults)
5. Stiff neck
6. Sensitivity to light (photophobia)
7. Bulging of the soft spots on the skull in infants (in infants)

Diagnosis: The diagnosis of pneumococcal meningitis is based on a combination of clinical findings, laboratory tests, and imaging studies. Laboratory tests may include blood cultures, cerebrospinal fluid (CSF) cultures, and polymerase chain reaction (PCR) to detect the presence of S. pneumoniae. Imaging studies, such as CT or MRI scans, may be used to evaluate the brain and identify any signs of inflammation or abscesses.

Treatment: Pneumococcal meningitis is typically treated with antibiotics, which are usually given intravenously. The choice of antibiotic depends on the severity of the infection and the patient's age and medical history. In addition to antibiotics, supportive care may be provided to manage symptoms such as fever, headache, and muscle aches. In severe cases, hospitalization may be necessary to monitor and treat the infection.

Complications: Pneumococcal meningitis can lead to serious complications, including:

1. Hearing loss
2. Learning disabilities
3. Behavioral changes
4. Seizures
5. Brain damage
6. Death

Prevention: Pneumococcal conjugate vaccine (PCV) is recommended for children under the age of 2 years and for certain high-risk groups, such as adults over the age of 65 and people with certain medical conditions. The vaccine can help prevent pneumococcal meningitis and other serious infections caused by S. pneumoniae. Good hygiene practices, such as frequent handwashing, can also help prevent the spread of the bacteria.

Prognosis: With prompt and appropriate treatment, the prognosis for pneumococcal meningitis is generally good. However, in severe cases or those with complications, the prognosis may be poorer. In some cases, long-term sequelae such as hearing loss, learning disabilities, and behavioral changes may occur.

Incubation period: The incubation period for pneumococcal meningitis is typically between 2 and 4 days, but it can range from 1 to 10 days.

Diagnosis: Pneumococcal meningitis is diagnosed based on a combination of clinical symptoms, physical examination findings, laboratory tests, and imaging studies such as CT or MRI scans. Laboratory tests may include blood cultures, cerebrospinal fluid (CSF) analysis, and PCR testing to identify the presence of S. pneumoniae.

Treatment: Treatment for pneumococcal meningitis typically involves antibiotics and supportive care to manage symptoms such as fever, headache, and muscle aches. In severe cases, hospitalization may be necessary to monitor and treat the infection.

In conclusion, pneumococcal meningitis is a serious infection that can cause significant morbidity and mortality. Prompt diagnosis and appropriate treatment are essential to prevent long-term sequelae and improve outcomes for affected individuals.

Reperfusion injury can cause inflammation, cell death, and impaired function in the affected tissue or organ. The severity of reperfusion injury can vary depending on the duration and severity of the initial ischemic event, as well as the promptness and effectiveness of treatment to restore blood flow.

Reperfusion injury can be a complicating factor in various medical conditions, including:

1. Myocardial infarction (heart attack): Reperfusion injury can occur when blood flow is restored to the heart muscle after a heart attack, leading to inflammation and cell death.
2. Stroke: Reperfusion injury can occur when blood flow is restored to the brain after an ischemic stroke, leading to inflammation and damage to brain tissue.
3. Organ transplantation: Reperfusion injury can occur when a transplanted organ is subjected to ischemia during harvesting or preservation, and then reperfused with blood.
4. Peripheral arterial disease: Reperfusion injury can occur when blood flow is restored to a previously occluded peripheral artery, leading to inflammation and damage to the affected tissue.

Treatment of reperfusion injury often involves medications to reduce inflammation and oxidative stress, as well as supportive care to manage symptoms and prevent further complications. In some cases, experimental therapies such as stem cell transplantation or gene therapy may be used to promote tissue repair and regeneration.

The disorder is caused by the damage of brain cells due to the deficiency of thiamine (Vitamin B1) which is essential for proper brain functioning. The condition can be divided into two main categories:

1. Wernicke's Encephalopathy: This is the acute form of the disorder where the individual experiences confusion, ataxia (loss of coordination), and oculomotor dysfunction (abnormal eye movements).
2. Korsakoff's Psychosis: This is the chronic form of the disorder where the individual experiences memory loss and confabulation (making up memories).

Symptoms of Alcohol Amnestic Disorder include:

* Memory loss for events that occurred both short-term and long-term
* Difficulty learning new information
* Confusion and disorientation
* Slurred speech and difficulty with coordination
* Increased risk of seizures

Diagnosis of the disorder is based on a combination of medical history, physical examination, and laboratory tests such as blood tests to check for thiamine deficiency. Treatment typically involves abstinence from alcohol, thiamine supplements, and supportive care to manage symptoms.

Prognosis for Alcohol Amnestic Disorder varies depending on the severity of the condition and the individual's response to treatment. In general, the earlier the diagnosis and treatment, the better the prognosis. However, if left untreated, the condition can lead to permanent brain damage and even death.

It is important to note that Alcohol Amnestic Disorder is preventable by avoiding excessive alcohol consumption and ensuring adequate thiamine intake through a balanced diet or supplements. Early detection and treatment can help to reduce the risk of long-term cognitive impairment and improve overall outcomes.

Examples of closed head injuries include:

* Concussions
* Contusions
* Cerebral edema (swelling of the brain)
* Brain hemorrhages (bleeding in the brain)

Closed head injuries can be caused by a variety of mechanisms, such as falls, motor vehicle accidents, sports injuries, and assaults.

Symptoms of closed head injuries may include:

* Headache
* Dizziness or loss of balance
* Confusion or disorientation
* Memory loss or difficulty concentrating
* Sleep disturbances
* Mood changes, such as irritability or depression
* Vision problems, such as blurred vision or sensitivity to light

Closed head injuries can be difficult to diagnose, as there may be no visible signs of injury. However, a healthcare provider may use imaging tests such as CT scans or MRI to look for evidence of damage to the brain. Treatment for closed head injuries typically involves rest, medication, and rehabilitation to help the patient recover from any cognitive, emotional, or physical symptoms. In some cases, surgery may be necessary to relieve pressure on the brain or repair damaged blood vessels.

1. Stroke: A stroke occurs when the blood supply to the brain is interrupted, either due to a blockage or a rupture of the blood vessels. This can lead to cell death and permanent brain damage.
2. Cerebral vasospasm: Vasospasm is a temporary constriction of the blood vessels in the brain, which can occur after a subarachnoid hemorrhage (bleeding in the space surrounding the brain).
3. Moyamoya disease: This is a rare condition caused by narrowing or blockage of the internal carotid artery and its branches. It can lead to recurrent transient ischemic attacks (TIs) or stroke.
4. Cerebral amyloid angiopathy: This is a condition where abnormal protein deposits accumulate in the blood vessels of the brain, leading to inflammation and bleeding.
5. Cavernous malformations: These are abnormal collections of blood vessels in the brain that can cause seizures, headaches, and other symptoms.
6. Carotid artery disease: Atherosclerosis (hardening) of the carotid arteries can lead to a stroke or TIAs.
7. Vertebrobasilar insufficiency: This is a condition where the blood flow to the brain is reduced due to narrowing or blockage of the vertebral and basilar arteries.
8. Temporal lobe dementia: This is a type of dementia that affects the temporal lobe of the brain, leading to memory loss and other cognitive symptoms.
9. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL): This is a rare genetic disorder that affects the blood vessels in the brain, leading to recurrent stroke-like events.
10. Moyamoya disease: This is a rare condition caused by narrowing or blockage of the internal carotid artery and its branches, leading to decreased blood flow to the brain and increased risk of stroke.

It's important to note that this list is not exhaustive and there may be other causes of stroke and TIAs that are not included here. A proper diagnosis can only be made by a qualified medical professional after conducting a thorough examination and reviewing the individual's medical history.

DAI is often seen in cases of mild traumatic brain injury (mTBI), also known as concussion, and is thought to be caused by the shearing forces that occur when the brain is subjected to rapid acceleration and deceleration, such as during a car accident or sports injury.

The symptoms of DAI can vary widely depending on the severity of the injury and may include:

* Memory loss
* Confusion
* Difficulty concentrating
* Dizziness and balance problems
* Sleep disturbances
* Mood changes, such as irritability or depression
* Changes in behavior, such as increased impulsivity or aggression

DAI is diagnosed through a combination of physical examination, medical history, and imaging tests, such as CT or MRI scans. Treatment for DAI typically focuses on managing symptoms and supporting the brain's natural healing process, and may include medication, physical therapy, and cognitive rehabilitation.

Prognosis for DAI varies depending on the severity of the injury, but in general, people with DAI can expect a full recovery within a few months to a year after the initial injury. However, some individuals may experience persistent symptoms or develop long-term cognitive and emotional changes as a result of the injury.

The signs and symptoms of fetal hypoxia may include:

1. Decreased fetal movement
2. Abnormal fetal heart rate
3. Meconium staining of the amniotic fluid
4. Premature contractions
5. Preterm labor

If left untreated, fetal hypoxia can lead to serious complications such as:

1. Intracranial hemorrhage
2. Cerebral palsy
3. Developmental delays
4. Learning disabilities
5. Memory and cognitive impairments
6. Behavioral problems
7. Autism
8. Seizures
9. Hearing and vision loss

Treatment of fetal hypoxia depends on the underlying cause, but may include:

1. Bed rest or hospitalization
2. Corticosteroids to promote fetal growth and maturity
3. Oxygen supplementation
4. Antibiotics for infections
5. Planned delivery, if necessary

In some cases, fetal hypoxia may be detected through ultrasound examination, which can show a decrease in fetal movement or abnormal heart rate. However, not all cases of fetal hypoxia can be detected by ultrasound, and regular prenatal check-ups are essential to monitor the health of the developing fetus.

Prevention of fetal hypoxia includes proper prenatal care, avoiding harmful substances such as tobacco and alcohol, maintaining a healthy diet, and managing any underlying medical conditions. Early detection and treatment of fetal hypoxia can significantly improve outcomes for both the mother and the baby.

Cerebrovascular Trauma is often caused by external factors such as traffic accidents, falls, sports injuries, or assaults. It can also be caused by internal factors such as blood clots or atherosclerosis (the buildup of plaque in the arteries).

There are several types of cerebrovascular trauma, including:

1. Cerebral contusions: These are bruises that occur when the brain is jolted or shaken, often as a result of a head injury.
2. Cerebral lacerations: These are cuts or tears in the brain tissue caused by a sharp object, such as a knife or a broken glass.
3. Cerebral hemorrhages: These occur when a blood vessel in the brain ruptures and bleeds into the surrounding tissue.
4. Cerebral infarctions: These are areas of dead brain tissue caused by a lack of blood flow, often as a result of a blood clot or atherosclerosis.

Diagnosis of cerebrovascular trauma typically involves imaging tests such as CT or MRI scans, and may also involve lumbar puncture (spinal tap) to collect cerebrospinal fluid for further analysis. Treatment depends on the type and severity of the injury, and may include medication, surgery, or rehabilitation therapy.

In summary, Cerebrovascular Trauma is a serious medical condition that can result in long-term cognitive, emotional, and behavioral changes. It is important to seek immediate medical attention if symptoms persist or worsen over time.

The symptoms of Alzheimer's disease can vary from person to person and may progress slowly over time. Early symptoms may include memory loss, confusion, and difficulty with problem-solving. As the disease progresses, individuals may experience language difficulties, visual hallucinations, and changes in mood and behavior.

There is currently no cure for Alzheimer's disease, but there are several medications and therapies that can help manage its symptoms and slow its progression. These include cholinesterase inhibitors, memantine, and non-pharmacological interventions such as cognitive training and behavioral therapy.

Alzheimer's disease is a significant public health concern, affecting an estimated 5.8 million Americans in 2020. It is the sixth leading cause of death in the United States, and its prevalence is expected to continue to increase as the population ages.

There is ongoing research into the causes and potential treatments for Alzheimer's disease, including studies into the role of inflammation, oxidative stress, and the immune system. Other areas of research include the development of biomarkers for early detection and the use of advanced imaging techniques to monitor progression of the disease.

Overall, Alzheimer's disease is a complex and multifactorial disorder that poses significant challenges for individuals, families, and healthcare systems. However, with ongoing research and advances in medical technology, there is hope for improving diagnosis and treatment options in the future.

There are two types of heart arrest:

1. Asystole - This is when the heart stops functioning completely and there is no electrical activity in the heart.
2. Pulseless ventricular tachycardia or fibrillation - This is when the heart is still functioning but there is no pulse and the rhythm is abnormal.

Heart arrest can be diagnosed through various tests such as electrocardiogram (ECG), blood tests, and echocardiography. Treatment options for heart arrest include cardiopulmonary resuscitation (CPR), defibrillation, and medications to restore a normal heart rhythm.

In severe cases of heart arrest, the patient may require advanced life support measures such as mechanical ventilation and cardiac support devices. The prognosis for heart arrest is generally poor, especially if it is not treated promptly and effectively. However, with proper treatment and support, some patients can recover and regain normal heart function.

Examples of Nervous System Diseases include:

1. Alzheimer's disease: A progressive neurological disorder that affects memory and cognitive function.
2. Parkinson's disease: A degenerative disorder that affects movement, balance and coordination.
3. Multiple sclerosis: An autoimmune disease that affects the protective covering of nerve fibers.
4. Stroke: A condition where blood flow to the brain is interrupted, leading to brain cell death.
5. Brain tumors: Abnormal growth of tissue in the brain.
6. Neuropathy: Damage to peripheral nerves that can cause pain, numbness and weakness in hands and feet.
7. Epilepsy: A disorder characterized by recurrent seizures.
8. Motor neuron disease: Diseases that affect the nerve cells responsible for controlling voluntary muscle movement.
9. Chronic pain syndrome: Persistent pain that lasts more than 3 months.
10. Neurodevelopmental disorders: Conditions such as autism, ADHD and learning disabilities that affect the development of the brain and nervous system.

These diseases can be caused by a variety of factors such as genetics, infections, injuries, toxins and ageing. Treatment options for Nervous System Diseases range from medications, surgery, rehabilitation therapy to lifestyle changes.

Symptoms of CNS lupus vasculitis can include headaches, seizures, confusion, weakness or paralysis, vision problems, and changes in personality or behavior. The condition can be difficult to diagnose, as it may mimic other conditions such as stroke, infection, or tumors.

Treatment of CNS lupus vasculitis typically involves high doses of corticosteroids to reduce inflammation and prevent further damage. In severe cases, intravenous immunoglobulin (IVIG) or plasmapheresis may be used to remove harmful antibodies from the blood. Anticoagulation therapy may also be prescribed to prevent blood clots.

While CNS lupus vasculitis can be a life-threatening condition, early diagnosis and aggressive treatment can improve outcomes. However, long-term follow-up is essential to monitor for recurrences of the disease and manage any ongoing neurological symptoms.

Causes:

1. Brain injury during fetal development or birth
2. Hypoxia (oxygen deficiency) to the brain, often due to complications during labor and delivery
3. Infections such as meningitis or encephalitis
4. Stroke or bleeding in the brain
5. Traumatic head injury
6. Genetic disorders
7. Premature birth
8. Low birth weight
9. Multiples (twins, triplets)
10. Maternal infections during pregnancy.

Symptoms:

1. Weakness or paralysis of muscles on one side of the body
2. Lack of coordination and balance
3. Difficulty with movement, posture, and gait
4. Spasticity (stiffness) or hypotonia (looseness) of muscles
5. Intellectual disability or learning disabilities
6. Seizures
7. Vision, hearing, or speech problems
8. Swallowing difficulties
9. Increased risk of infections and bone fractures
10. Delays in reaching developmental milestones.

Diagnosis:

1. Physical examination and medical history
2. Imaging tests, such as CT or MRI scans
3. Electromyography (EMG) to test muscle activity
4. Developmental assessments to evaluate cognitive and motor skills
5. Genetic testing to identify underlying causes.

Treatment:

1. Physical therapy to improve movement, balance, and strength
2. Occupational therapy to develop daily living skills and fine motor activities
3. Speech therapy for communication and swallowing difficulties
4. Medications to control seizures, spasticity, or pain
5. Surgery to correct anatomical abnormalities or release contracted muscles
6. Assistive devices, such as braces, walkers, or wheelchairs, to aid mobility and independence.

It's important to note that each individual with Cerebral Palsy may have a unique combination of symptoms and require a personalized treatment plan. With appropriate medical care and support, many individuals with Cerebral Palsy can lead fulfilling lives and achieve their goals despite the challenges they face.

The risk of developing PTE is highest in individuals who experienced a severe head injury, such as a concussion, contusion, or penetrating injury. Additionally, the risk is higher if the injury involved the temporal lobe, which is a part of the brain that is prone to seizures.

Post-traumatic epilepsy can be difficult to diagnose because it may not develop until years after the initial trauma. The symptoms of PTE can also be similar to other conditions, such as post-traumatic stress disorder (PTSD). Therefore, it is important for individuals who have experienced a head injury to receive regular follow-up care with a healthcare provider.

There are several types of seizures that can occur in PTE, including:

1. Generalized seizures: These seizures affect both sides of the brain and can cause symptoms such as convulsions, muscle stiffness, and loss of consciousness.
2. Partial seizures: These seizures affect only one part of the brain and can cause symptoms such as confusion, weakness, or numbness.
3. Simple partial seizures: These seizures do not involve convulsions or loss of consciousness and may be accompanied by symptoms such as staring spells or repetitive movements.
4. Complex partial seizures: These seizures involve both the conscious and unconscious mind and can cause symptoms such as confusion, hallucinations, and changes in behavior.

There are several treatment options for PTE, including medication, surgery, and lifestyle modifications. The goal of treatment is to control seizures and improve quality of life. In some cases, PTE may be a lifelong condition, but with proper management, individuals can lead fulfilling lives.

Overall, post-traumatic epilepsy is a serious condition that can have a significant impact on an individual's quality of life. If you or someone you know has experienced a traumatic brain injury and is experiencing seizures, it is important to seek medical attention as soon as possible. With proper diagnosis and treatment, it is possible to manage PTE and improve overall health and well-being.

PVL is often seen in premature infants, especially those born before 32 weeks of gestation, as their brains are not fully developed and are more susceptible to injury. It can also occur in full-term newborns who have experienced hypoxia (lack of oxygen) during delivery or shortly after birth.

The symptoms of PVL can vary depending on the severity of the condition and may include:

* Delayed developmental milestones
* Poor muscle tone and coordination
* Seizures
* Vision problems
* Hearing loss

PVL is typically diagnosed through a combination of physical examination, medical history, and imaging studies such as ultrasound or MRI. Treatment for PVL often focuses on managing the underlying cause, such as hypoxia or infection, and providing supportive care to help the brain heal. In some cases, medications may be prescribed to help control seizures or other symptoms.

Overall, periventricular leukomalacia is a serious condition that can have long-lasting effects on the developing brain, but with proper medical care and support, many children are able to recover and lead normal lives.

There are two main types of status epilepticus:

1. Generalized status epilepticus: This type affects the entire brain and is characterized by severe convulsions, loss of consciousness, and muscle stiffness.
2. Focal status epilepticus: This type affects only one part of the brain and can cause more subtle symptoms, such as weakness or numbness in a limb, speech difficulties, or confusion.

The diagnosis of status epilepticus is based on clinical findings, medical history, and electroencephalography (EEG) recordings. Treatment typically involves prompt administration of anticonvulsant medications, such as benzodiazepines or barbiturates, to control seizures and prevent further brain damage. In severe cases, sedation, mechanical ventilation, or anesthesia may be required to support the patient's vital functions.

The prognosis for status epilepticus depends on several factors, including the underlying cause, the severity of the seizure, and the promptness and effectiveness of treatment. In general, the earlier the treatment is initiated, the better the outcome. However, long-term neurological and cognitive deficits can occur in some cases.

Preventive measures for status epilepticus include proper management of underlying conditions that may trigger seizures, such as epilepsy or head trauma, and avoiding triggers like alcohol or drugs. Additionally, prompt medical attention should be sought if seizure warning signs are present, such as changes in sensation, confusion, or convulsions.

Gliosis is made up of glial cells, which are non-neuronal cells that provide support and protection to neurons. When neural tissue is damaged, glial cells proliferate and form a scar-like tissue to fill in the gap and repair the damage. This scar tissue can be made up of astrocytes, oligodendrocytes, or microglia, depending on the type of injury and the location of the damage.

Gliosis can have both beneficial and harmful effects on the brain. On one hand, it can help to prevent further damage by providing a physical barrier against invading substances and protecting the surrounding neural tissue. It can also promote healing by bringing in immune cells and growth factors that aid in the repair process.

On the other hand, gliosis can also have negative effects on brain function. The scar tissue can disrupt normal communication between neurons, leading to impaired cognitive and motor function. In addition, if the scar tissue is too extensive or severe, it can compress or displaces surrounding neural tissue, leading to long-term neurological deficits or even death.

There are several ways to diagnose gliosis, including magnetic resonance imaging (MRI), positron emission tomography (PET), and histopathology. Treatment options for gliosis depend on the underlying cause of the condition and can include medications, surgery, or a combination of both.

In summary, gliosis is a type of scar tissue that forms in the brain and spinal cord as a result of damage to neural tissue. It can have both beneficial and harmful effects on brain function, and diagnosis and treatment options vary depending on the underlying cause of the condition.

Hemiplegia can cause a range of symptoms including weakness, paralysis, loss of sensation, and difficulty with movement and coordination on one side of the body. The affected side may also experience muscle spasticity or rigidity, causing stiffness and limited mobility.

Depending on the severity and location of the damage, hemiplegia can be classified into different types:

1. Left hemiplegia: This type affects the left side of the body and is caused by damage to the left hemisphere of the brain.
2. Right hemiplegia: This type affects the right side of the body and is caused by damage to the right hemisphere of the brain.
3. Mixed hemiplegia: This type affects both sides of the body and is caused by damage to both hemispheres of the brain or other areas of the brainstem.
4. Progressive hemiplegia: This type progressively worsens over time and is often associated with neurodegenerative disorders such as Parkinson's disease or multiple sclerosis.

Treatment for hemiplegia typically focuses on physical therapy, occupational therapy, and rehabilitation to improve mobility, strength, and function. Medications such as anticonvulsants, muscle relaxants, and pain relievers may also be prescribed to manage symptoms. In severe cases, surgery may be necessary to relieve pressure on the brain or spinal cord.

In summary, hemiplegia is a condition characterized by paralysis or weakness on one side of the body, often caused by damage to the brain or spinal cord. Treatment options vary depending on the severity and underlying cause of the condition.

1. Fatigue and weakness: Thiamine is necessary for the production of ATP, the primary source of energy for the body's cells. Without enough thiamine, cells may not be able to produce enough ATP, leading to fatigue, weakness, and a lack of endurance.
2. Numbness and tingling: Thiamine is important for the health of the peripheral nerves, which can cause numbness, tingling, and pain in the hands and feet if there is a deficiency.
3. Memory loss and confusion: Thiamine is necessary for the proper functioning of the brain and can lead to memory loss, confusion, and difficulty concentrating if there is a deficiency.
4. Mood changes: Thiamine plays a role in the production of neurotransmitters, such as serotonin and dopamine, which are important for mood regulation. A thiamine deficiency can lead to mood changes, such as depression, anxiety, and irritability.
5. Digestive problems: Thiamine is necessary for the proper functioning of the digestive system, and a deficiency can lead to nausea, vomiting, diarrhea, and abdominal pain.
6. Heart problems: Thiamine is important for the health of the heart, and a deficiency can lead to heart failure, arrhythmias, and other cardiovascular problems.
7. Weight loss: Thiamine is necessary for the proper metabolism of carbohydrates, fats, and proteins, and a deficiency can lead to weight loss and muscle wasting.
8. Beriberi: A severe thiamine deficiency can lead to beriberi, a condition characterized by weakness, fatigue, and a range of other health problems.

Thiamine deficiency can be caused by a variety of factors, including:

1. Poor diet: A diet that is low in thiamine-rich foods, such as whole grains, lean meats, and fish, can lead to a deficiency.
2. Alcoholism: Alcohol can interfere with the absorption of thiamine in the gut, leading to a deficiency.
3. Gastrointestinal disorders: Certain conditions, such as Crohn's disease and ulcerative colitis, can lead to malabsorption of thiamine and other nutrients.
4. Medications: Some medications, such as furosemide and other diuretics, can interfere with the absorption of thiamine.
5. Genetic disorders: Certain genetic disorders, such as maple syrup urine disease, can lead to a thiamine deficiency.

If you suspect that you or someone you know may have a thiamine deficiency, it is important to consult with a healthcare professional for proper diagnosis and treatment. Treatment typically involves supplementation with thiamine, along with addressing any underlying causes of the deficiency. In severe cases, hospitalization may be necessary to manage symptoms and prevent complications.

There are several causes of hemianopsia, including:

1. Stroke or cerebral vasculitis: These conditions can damage the occipital lobe and result in hemianopsia.
2. Brain tumors: Tumors in the occipital lobe can cause hemianopsia by compressing or damaging the visual pathways.
3. Traumatic brain injury: A head injury can cause damage to the occipital lobe and result in hemianopsia.
4. Cerebral palsy: This condition can cause brain damage that leads to hemianopsia.
5. Multiple sclerosis: This autoimmune disease can cause damage to the visual pathways and result in hemianopsia.

Symptoms of hemianopsia may include:

1. Blindness or impaired vision in one side of both eyes.
2. Difficulty recognizing objects or people on one side of the visual field.
3. Inability to see objects that are peripheral to the affected side.
4. Difficulty with depth perception and spatial awareness.
5. Eye movements that are abnormal or restricted.

Diagnosis of hemianopsia typically involves a comprehensive eye exam, including visual acuity testing, visual field testing, and imaging studies such as MRI or CT scans to evaluate the brain. Treatment options for hemianopsia depend on the underlying cause and may include:

1. Glasses or contact lenses to correct refractive errors.
2. Prism lenses to realign the visual image.
3. Visual therapy to improve remaining vision.
4. Medications to treat underlying conditions such as multiple sclerosis or brain tumors.
5. Surgery to repair damaged blood vessels or relieve pressure on the brain.

It is important to note that hemianopsia can significantly impact daily life and may affect an individual's ability to perform certain tasks, such as driving or reading. However, with proper diagnosis and treatment, many people with hemianopsia are able to adapt and lead fulfilling lives.

There are different types of amnesia, including:

1. Retrograde amnesia: loss of memory of events that occurred before the onset of amnesia.
2. Anterograde amnesia: inability to form new memories after the onset of amnesia.
3. Transient global amnesia: temporary and reversible loss of memory due to a specific cause, such as a stroke or a head injury.
4. Korsakoff's syndrome: a condition caused by alcoholism and malnutrition that affects the hippocampus and the ability to form new memories.
5. Dissociative amnesia: loss of memory due to psychological trauma or stress, often accompanied by dissociation from reality.

The symptoms of amnesia can vary depending on the underlying cause and the severity of the condition. Some common symptoms include:

1. Difficulty learning new information
2. Forgetting recent events or conversations
3. Inability to recall past events or experiences
4. Confusion and disorientation
5. Difficulty with problem-solving and decision-making

The diagnosis of amnesia is based on a combination of medical history, physical examination, and neuropsychological tests. Imaging studies such as CT or MRI scans may also be used to rule out other causes of memory loss.

Treatment for amnesia depends on the underlying cause and may include:

1. Medications to manage symptoms such as anxiety, depression, or cognitive impairment.
2. Cognitive rehabilitation therapy to improve memory and problem-solving skills.
3. Behavioral interventions to help the individual adapt to their condition.
4. In some cases, surgery may be necessary to treat the underlying cause of amnesia, such as a tumor or a blood clot.

Overall, amnesia can have a significant impact on an individual's quality of life, but with proper diagnosis and treatment, many people are able to manage their symptoms and lead fulfilling lives.

There are several types of apraxias, each with distinct symptoms and characteristics:

1. Ideomotor apraxia: Difficulty performing specific movements or gestures, such as grasping and manipulating objects, due to a lack of understanding of the intended purpose or meaning of the action.
2. Ideational apraxia: Inability to initiate or perform movements due to a lack of understanding of the task or goal.
3. Kinesthetic apraxia: Difficulty judging the weight, shape, size, and position of objects in space, leading to difficulties with grasping, manipulating, or coordinating movements.
4. Graphomotor apraxia: Difficulty writing or drawing due to a lack of coordination between the hand and the intended movement.
5. Dressing apraxia: Difficulty dressing oneself due to a lack of coordination and planning for the movements required to put on clothes.
6. Gait apraxia: Difficulty walking or maintaining balance due to a lack of coordinated movement of the legs, trunk, and arms.
7. Speech apraxia: Difficulty articulating words or sounds due to a lack of coordination between the mouth, tongue, and lips.

The diagnosis of apraxias typically involves a comprehensive neurological examination, including assessments of motor function, language, and cognitive abilities. Treatment options vary depending on the underlying cause and severity of the apraxia, but may include physical therapy, speech therapy, occupational therapy, and medication.

Necrosis is a type of cell death that occurs when cells are exposed to excessive stress, injury, or inflammation, leading to damage to the cell membrane and the release of cellular contents into the surrounding tissue. This can lead to the formation of gangrene, which is the death of body tissue due to lack of blood supply.

There are several types of necrosis, including:

1. Coagulative necrosis: This type of necrosis occurs when there is a lack of blood supply to the tissues, leading to the formation of a firm, white plaque on the surface of the affected area.
2. Liquefactive necrosis: This type of necrosis occurs when there is an infection or inflammation that causes the death of cells and the formation of pus.
3. Caseous necrosis: This type of necrosis occurs when there is a chronic infection, such as tuberculosis, and the affected tissue becomes soft and cheese-like.
4. Fat necrosis: This type of necrosis occurs when there is trauma to fatty tissue, leading to the formation of firm, yellowish nodules.
5. Necrotizing fasciitis: This is a severe and life-threatening form of necrosis that affects the skin and underlying tissues, often as a result of bacterial infection.

The diagnosis of necrosis is typically made through a combination of physical examination, imaging studies such as X-rays or CT scans, and laboratory tests such as biopsy. Treatment depends on the underlying cause of the necrosis and may include antibiotics, surgical debridement, or amputation in severe cases.

The different types of Neurotoxicity Syndromes include:

1. Organophosphate-induced neurotoxicity: This syndrome is caused by exposure to organophosphate pesticides, which can damage the nervous system and cause symptoms such as headaches, dizziness, and memory loss.
2. Heavy metal neurotoxicity: Exposure to heavy metals, such as lead, mercury, and arsenic, can damage the nervous system and cause symptoms such as tremors, muscle weakness, and cognitive impairment.
3. Pesticide-induced neurotoxicity: This syndrome is caused by exposure to pesticides, which can damage the nervous system and cause symptoms such as headaches, dizziness, and memory loss.
4. Solvent-induced neurotoxicity: Exposure to solvents, such as toluene and benzene, can damage the nervous system and cause symptoms such as memory loss, difficulty with concentration, and mood changes.
5. Medication-induced neurotoxicity: Certain medications, such as antidepressants and antipsychotics, can damage the nervous system and cause symptoms such as tremors, muscle rigidity, and cognitive impairment.
6. Environmental neurotoxicity: Exposure to environmental toxins, such as air pollution and pesticides, can damage the nervous system and cause symptoms such as headaches, dizziness, and memory loss.
7. Neurodegenerative disease-induced neurotoxicity: Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, can cause neurotoxicity and lead to symptoms such as cognitive decline, memory loss, and motor dysfunction.
8. Traumatic brain injury-induced neurotoxicity: Traumatic brain injury can cause neurotoxicity and lead to symptoms such as cognitive impairment, memory loss, and mood changes.
9. Stroke-induced neurotoxicity: A stroke can cause neurotoxicity and lead to symptoms such as weakness or paralysis on one side of the body, difficulty with speech and language, and memory loss.
10. Neurodevelopmental disorder-induced neurotoxicity: Neurodevelopmental disorders, such as autism spectrum disorder, can cause neurotoxicity and lead to symptoms such as cognitive impairment, social withdrawal, and repetitive behaviors.

It is important to note that these are just a few examples of the many different types of neurotoxicity that can occur, and that each type may have its own unique set of causes, symptoms, and treatments. If you suspect that you or someone you know may be experiencing neurotoxicity, it is important to seek medical attention as soon as possible in order to receive an accurate diagnosis and appropriate treatment.

Some common examples of neurodegenerative diseases include:

1. Alzheimer's disease: A progressive loss of cognitive function, memory, and thinking skills that is the most common form of dementia.
2. Parkinson's disease: A disorder that affects movement, balance, and coordination, causing tremors, rigidity, and difficulty with walking.
3. Huntington's disease: An inherited condition that causes progressive loss of cognitive, motor, and psychiatric functions.
4. Amyotrophic lateral sclerosis (ALS): A disease that affects the nerve cells responsible for controlling voluntary muscle movement, leading to muscle weakness, paralysis, and eventually death.
5. Prion diseases: A group of rare and fatal disorders caused by misfolded proteins in the brain, leading to neurodegeneration and death.
6. Creutzfeldt-Jakob disease: A rare, degenerative, and fatal brain disorder caused by an abnormal form of a protein called a prion.
7. Frontotemporal dementia: A group of diseases that affect the front and temporal lobes of the brain, leading to changes in personality, behavior, and language.

Neurodegenerative diseases can be caused by a variety of factors, including genetics, age, lifestyle, and environmental factors. They are typically diagnosed through a combination of medical history, physical examination, laboratory tests, and imaging studies. Treatment options for neurodegenerative diseases vary depending on the specific condition and its underlying causes, but may include medications, therapy, and lifestyle changes.

Preventing or slowing the progression of neurodegenerative diseases is a major focus of current research, with various potential therapeutic strategies being explored, such as:

1. Stem cell therapies: Using stem cells to replace damaged neurons and restore brain function.
2. Gene therapies: Replacing or editing genes that are linked to neurodegenerative diseases.
3. Small molecule therapies: Developing small molecules that can slow or prevent the progression of neurodegenerative diseases.
4. Immunotherapies: Harnessing the immune system to combat neurodegenerative diseases.
5. Lifestyle interventions: Promoting healthy lifestyle choices, such as regular exercise and a balanced diet, to reduce the risk of developing neurodegenerative diseases.

In conclusion, neurodegenerative diseases are a complex and diverse group of disorders that can have a profound impact on individuals and society. While there is currently no cure for these conditions, research is providing new insights into their causes and potential treatments. By continuing to invest in research and developing innovative therapeutic strategies, we can work towards improving the lives of those affected by neurodegenerative diseases and ultimately finding a cure.

Anomia is a condition characterized by memory loss or impairment of word-finding ability, especially for proper nouns (e.g., names of people and places). Also called nominal anomia or dysnomia.

Anomia can be caused by various factors, such as brain injury, stroke, traumatic brain injury, neurodegenerative diseases (e.g., Alzheimer's disease), infections (e.g., encephalitis), and certain medications.

Symptoms of anomia may include difficulty naming objects or people, trouble finding the right words to describe something, and confusion about the meaning of words. In some cases, anomia can be treated with speech and language therapy, but in more severe cases, it may be a permanent condition.

There are different types of anoxia, including:

1. Cerebral anoxia: This occurs when the brain does not receive enough oxygen, leading to cognitive impairment, confusion, and loss of consciousness.
2. Pulmonary anoxia: This occurs when the lungs do not receive enough oxygen, leading to shortness of breath, coughing, and chest pain.
3. Cardiac anoxia: This occurs when the heart does not receive enough oxygen, leading to cardiac arrest and potentially death.
4. Global anoxia: This is a complete lack of oxygen to the entire body, leading to widespread tissue damage and death.

Treatment for anoxia depends on the underlying cause and the severity of the condition. In some cases, hospitalization may be necessary to provide oxygen therapy, pain management, and other supportive care. In severe cases, anoxia can lead to long-term disability or death.

Prevention of anoxia is important, and this includes managing underlying medical conditions such as heart disease, diabetes, and respiratory problems. It also involves avoiding activities that can lead to oxygen deprivation, such as scuba diving or high-altitude climbing, without proper training and equipment.

In summary, anoxia is a serious medical condition that occurs when there is a lack of oxygen in the body or specific tissues or organs. It can cause cell death and tissue damage, leading to serious health complications and even death if left untreated. Early diagnosis and treatment are crucial to prevent long-term disability or death.

In extreme cases, hypoglycemia can lead to seizures, loss of consciousness, and even coma. It is important to recognize the symptoms of hypoglycemia early on and seek medical attention if they persist or worsen over time. Treatment typically involves raising blood sugar levels through the consumption of quick-acting carbohydrates such as glucose tablets, fruit juice, or hard candy.

If left untreated, hypoglycemia can have serious consequences, including long-term damage to the brain, heart, and other organs. It is important for individuals with diabetes to monitor their blood sugar levels regularly and work with their healthcare provider to manage their condition effectively.

Some common types of memory disorders include:

1. Amnesia: A condition where an individual experiences memory loss, either partial or total, due to brain damage or other causes.
2. Dementia: A broad term that describes a decline in cognitive function, including memory loss, confusion, and difficulty with communication and daily activities. Alzheimer's disease is the most common cause of dementia.
3. Mild Cognitive Impairment (MCI): A condition characterized by memory loss and other cognitive symptoms that are more severe than normal age-related changes but not as severe as dementia.
4. Attention Deficit Hyperactivity Disorder (ADHD): A neurodevelopmental disorder that affects attention, impulse control, and hyperactivity. Memory problems are often a component of ADHD.
5. Traumatic Brain Injury (TBI): A condition that occurs when the brain is injured due to a blow or jolt to the head, which can result in memory loss and other cognitive problems.
6. Stroke: A condition where blood flow to the brain is interrupted, leading to brain cell death and potential memory loss.
7. Meningitis: An inflammatory condition that affects the membranes covering the brain and spinal cord, which can lead to memory loss and other cognitive problems.
8. Encephalitis: An inflammatory condition that affects the brain directly, leading to memory loss and other cognitive problems.
9. Chronic Fatigue Syndrome (CFS): A condition characterized by persistent fatigue, memory loss, and other cognitive symptoms.
10. Sleep Disorders: Sleep disturbances can affect memory and cognitive function, including conditions such as insomnia, sleep apnea, and restless leg syndrome.

The diagnosis of memory disorders typically involves a combination of medical history, physical examination, laboratory tests, and neuropsychological evaluations. The specific treatment approach will depend on the underlying cause of the memory loss, but may include medication, behavioral interventions, and lifestyle changes.

There are several key features of inflammation:

1. Increased blood flow: Blood vessels in the affected area dilate, allowing more blood to flow into the tissue and bringing with it immune cells, nutrients, and other signaling molecules.
2. Leukocyte migration: White blood cells, such as neutrophils and monocytes, migrate towards the site of inflammation in response to chemical signals.
3. Release of mediators: Inflammatory mediators, such as cytokines and chemokines, are released by immune cells and other cells in the affected tissue. These molecules help to coordinate the immune response and attract more immune cells to the site of inflammation.
4. Activation of immune cells: Immune cells, such as macrophages and T cells, become activated and start to phagocytose (engulf) pathogens or damaged tissue.
5. Increased heat production: Inflammation can cause an increase in metabolic activity in the affected tissue, leading to increased heat production.
6. Redness and swelling: Increased blood flow and leakiness of blood vessels can cause redness and swelling in the affected area.
7. Pain: Inflammation can cause pain through the activation of nociceptors (pain-sensing neurons) and the release of pro-inflammatory mediators.

Inflammation can be acute or chronic. Acute inflammation is a short-term response to injury or infection, which helps to resolve the issue quickly. Chronic inflammation is a long-term response that can cause ongoing damage and diseases such as arthritis, asthma, and cancer.

There are several types of inflammation, including:

1. Acute inflammation: A short-term response to injury or infection.
2. Chronic inflammation: A long-term response that can cause ongoing damage and diseases.
3. Autoimmune inflammation: An inappropriate immune response against the body's own tissues.
4. Allergic inflammation: An immune response to a harmless substance, such as pollen or dust mites.
5. Parasitic inflammation: An immune response to parasites, such as worms or fungi.
6. Bacterial inflammation: An immune response to bacteria.
7. Viral inflammation: An immune response to viruses.
8. Fungal inflammation: An immune response to fungi.

There are several ways to reduce inflammation, including:

1. Medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and disease-modifying anti-rheumatic drugs (DMARDs).
2. Lifestyle changes, such as a healthy diet, regular exercise, stress management, and getting enough sleep.
3. Alternative therapies, such as acupuncture, herbal supplements, and mind-body practices.
4. Addressing underlying conditions, such as hormonal imbalances, gut health issues, and chronic infections.
5. Using anti-inflammatory compounds found in certain foods, such as omega-3 fatty acids, turmeric, and ginger.

It's important to note that chronic inflammation can lead to a range of health problems, including:

1. Arthritis
2. Diabetes
3. Heart disease
4. Cancer
5. Alzheimer's disease
6. Parkinson's disease
7. Autoimmune disorders, such as lupus and rheumatoid arthritis.

Therefore, it's important to manage inflammation effectively to prevent these complications and improve overall health and well-being.

There are several subtypes of agnosia, each with distinct symptoms:

1. Visual agnosia: Difficulty recognizing objects, colors, or shapes.
2. Auditory agnosia: Inability to recognize familiar sounds or voices.
3. Tactile agnosia: Difficulty identifying objects by touch.
4. Olfactory agnosia: Loss of the ability to smell.
5. Gustatory agnosia: Inability to taste or identify different flavors.
6. Hyperagnosia: Excessive sensitivity to stimuli, leading to over-recognition of objects and excessive memory for details.
7. Hypoagnosia: Under-recognition of objects, leading to difficulty identifying familiar items.

Agnosia can be caused by various factors, such as stroke, traumatic brain injury, infections, neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease), and developmental disorders (e.g., autism spectrum disorder). Treatment options depend on the underlying cause of the agnosia and may include rehabilitation therapies, medications, or surgery.

In summary, agnosia is a neurological condition characterized by difficulty in recognizing objects, voices, or other sensory stimuli due to damage to specific areas of the brain. It can affect one or more senses and can be caused by various factors. Treatment options vary depending on the underlying cause of the disorder.

The committee defined "brain death" as follows:

* The absence of any clinical or electrophysiological signs of consciousness, including the lack of response to pain, light, sound, or other stimuli.
* The absence of brainstem reflexes, such as pupillary reactivity, oculocephalic reflex, and gag reflex.
* The failure of all brain waves, including alpha, beta, theta, delta, and epsilon waves, as detected by electroencephalography (EEG).
* The absence of any other clinical or laboratory signs of life, such as heartbeat, breathing, or blood circulation.

The definition of brain death is important because it provides a clear and consistent criteria for determining death in medical settings. It helps to ensure that patients who are clinically dead are not inappropriately kept on life support, and that organ donation can be performed in a timely and ethical manner.

There are several possible causes of hyperglycemia, including:

1. Diabetes: This is a chronic condition where the body either does not produce enough insulin or cannot use insulin effectively.
2. Insulin resistance: This occurs when the body's cells become less responsive to insulin, leading to high blood sugar levels.
3. Pancreatitis: This is inflammation of the pancreas, which can lead to high blood sugar levels.
4. Cushing's syndrome: This is a rare hormonal disorder that can cause high blood sugar levels.
5. Medications: Certain medications, such as steroids and some types of antidepressants, can raise blood sugar levels.
6. Stress: Stress can cause the release of hormones such as cortisol and adrenaline, which can raise blood sugar levels.
7. Infections: Certain infections, such as pneumonia or urinary tract infections, can cause high blood sugar levels.
8. Trauma: Traumatic injuries can cause high blood sugar levels due to the release of stress hormones.
9. Surgery: Some types of surgery, such as heart bypass surgery, can cause high blood sugar levels.
10. Pregnancy: High blood sugar levels can occur during pregnancy, especially in women who have a history of gestational diabetes.

Hyperglycemia can cause a range of symptoms, including:

1. Increased thirst and urination
2. Fatigue
3. Blurred vision
4. Headaches
5. Cuts or bruises that are slow to heal
6. Tingling or numbness in the hands and feet
7. Dry, itchy skin
8. Flu-like symptoms, such as weakness, dizziness, and stomach pain
9. Recurring skin, gum, or bladder infections
10. Sexual dysfunction in men and women

If left untreated, hyperglycemia can lead to serious complications, including:

1. Diabetic ketoacidosis (DKA): A life-threatening condition that occurs when the body produces high levels of ketones, which are acidic substances that can cause confusion, nausea, and vomiting.
2. Hypoglycemia: Low blood sugar levels that can cause dizziness, confusion, and even loss of consciousness.
3. Nerve damage: High blood sugar levels over an extended period can damage the nerves, leading to numbness, tingling, and pain in the hands and feet.
4. Kidney damage: The kidneys may become overworked and damaged if they are unable to filter out the excess glucose in the blood.
5. Eye damage: High blood sugar levels can cause damage to the blood vessels in the eyes, leading to vision loss and blindness.
6. Cardiovascular disease: Hyperglycemia can increase the risk of cardiovascular disease, including heart attacks, strokes, and peripheral artery disease.
7. Cognitive impairment: Hyperglycemia has been linked to cognitive impairment and an increased risk of dementia.

It is essential to manage hyperglycemia by making lifestyle changes, such as following a healthy diet, regular exercise, and taking medication if prescribed by a healthcare professional. Monitoring blood sugar levels regularly can help identify the signs of hyperglycemia and prevent long-term complications.

The key symptoms of Korsakoff syndrome are:

* Memory loss: Sufferers experience difficulty in forming new memories, which can result in short-term memory loss. They may not remember recent events or conversations, and may have trouble recalling information they learned recently.
* Confabulation: Individuals with Korsakoff syndrome may fill in memory gaps with fabricated information, leading to confabulation (false memories). This can result in inaccurate or distorted recollections of past events.
* Dissociation: The condition can lead to dissociative symptoms such as depersonalization (feeling detached from oneself) and derealization (feeling detached from the world around them).

Korsakoff syndrome is a serious condition that requires prompt medical attention, particularly if it is caused by severe alcoholism or malnutrition. Treatment typically involves addressing the underlying cause of the disorder, such as stopping alcohol consumption and correcting any nutritional deficiencies. In some cases, medication may be prescribed to manage symptoms like anxiety or depression.

The condition is often seen in people who have a history of chronic alcoholism, although it can also occur in individuals with other conditions that affect the brain and central nervous system. Korsakoff syndrome can significantly impact an individual's ability to function in daily life, particularly if left untreated.

There are several types of intracranial hemorrhage, including:

1. Cerebral hemorrhage: Bleeding within the cerebral tissue itself, which can cause damage to brain cells and lead to a variety of complications.
2. Subarachnoid hemorrhage: Bleeding between the brain and the thin membrane that covers it (the meninges), which can cause severe headaches and other symptoms.
3. Epidural hemorrhage: Bleeding between the dura mater, a protective layer of tissue surrounding the brain, and the skull.
4. Subdural hemorrhage: Bleeding between the dura mater and the arachnoid membrane, which can cause severe headaches and other symptoms.

The symptoms of intracranial hemorrhage can vary depending on the location and severity of the bleeding, but may include:

* Sudden, severe headache
* Nausea and vomiting
* Confusion and disorientation
* Weakness or numbness in the face, arm, or leg
* Seizures
* Loss of consciousness

Diagnosis is typically made through a combination of physical examination, imaging tests (such as CT or MRI scans), and laboratory tests to determine the cause of the hemorrhage. Treatment depends on the location and severity of the bleeding, but may include medications to control symptoms, surgery to repair the source of the bleeding, or other interventions as needed.

There are various causes of intellectual disability, including:

1. Genetic disorders, such as Down syndrome, Fragile X syndrome, and Turner syndrome.
2. Congenital conditions, such as microcephaly and hydrocephalus.
3. Brain injuries, such as traumatic brain injury or hypoxic-ischemic injury.
4. Infections, such as meningitis or encephalitis.
5. Nutritional deficiencies, such as iron deficiency or iodine deficiency.

Intellectual disability can result in a range of cognitive and functional impairments, including:

1. Delayed language development and difficulty with communication.
2. Difficulty with social interactions and adapting to new situations.
3. Limited problem-solving skills and difficulty with abstract thinking.
4. Slow learning and memory difficulties.
5. Difficulty with fine motor skills and coordination.

There is no cure for intellectual disability, but early identification and intervention can significantly improve outcomes. Treatment options may include:

1. Special education programs tailored to the individual's needs.
2. Behavioral therapies, such as applied behavior analysis (ABA) and positive behavior support (PBS).
3. Speech and language therapy.
4. Occupational therapy to improve daily living skills.
5. Medications to manage associated behaviors or symptoms.

It is essential to recognize that intellectual disability is a lifelong condition, but with appropriate support and resources, individuals with ID can lead fulfilling lives and reach their full potential.

The symptoms of WE can vary depending on the severity of the deficiency, but common manifestations include:

1. Confusion and disorientation
2. Memory loss and difficulty learning new information
3. Difficulty with coordination and balance
4. Loss of muscle tone and weakness in the arms and legs
5. Disturbances in vision, hearing, and taste
6. Nausea and vomiting
7. Abnormalities in heart rate and blood pressure
8. Increased risk of seizures and coma

If left untreated, WE can lead to more severe complications such as Wernicke-Korsakoff Syndrome (WKS), a condition that involves the loss of brain tissue and memory loss. Treatment for WE typically involves thiamine supplements and addressing any underlying causes of the deficiency. In severe cases, hospitalization may be necessary to monitor and treat complications.

Types of Alcoholic Psychoses:

1. Alcohol-related psychosis (ARP): This type of psychosis can occur in people who are intoxicated or experiencing withdrawal symptoms after stopping alcohol use. Symptoms include hallucinations, delusions, and disorganized thinking and behavior.
2. Korsakoff's syndrome: This is a memory disorder that occurs as a result of vitamin B1 (thiamine) deficiency caused by heavy drinking. People with Korsakoff's syndrome may experience confusion, amnesia, and psychotic symptoms such as hallucinations and delusions.
3. Wernicke-Korsakoff syndrome: This is a disorder that affects the brain and nervous system, caused by a combination of thiamine deficiency and chronic alcohol consumption. Symptoms include confusion, memory loss, and psychotic symptoms such as hallucinations and delusions.

Causes and Risk Factors:

1. Alcohol use: The primary cause of alcoholic psychosis is excessive and long-term alcohol consumption.
2. Genetics: People with a family history of mental health issues may be more susceptible to developing alcoholic psychosis.
3. Nutritional deficiencies: Poor nutrition, especially a lack of vitamin B1 (thiamine), can contribute to the development of alcoholic psychosis.
4. Brain changes: Long-term heavy drinking can cause changes in brain structure and function, which may increase the risk of developing psychotic symptoms.
5. Other factors: Trauma, stress, and social isolation may also contribute to the development of alcoholic psychosis.

Symptoms:

1. Hallucinations: People with alcoholic psychosis may experience hallucinations that can be visual, auditory, or both. These can range from simple sounds or voices to complex visions or conversations.
2. Delusions: Delusions are false beliefs that are not based in reality and cannot be explained by a person's cultural or religious beliefs. In alcoholic psychosis, delusions can range from paranoid thoughts to grandiose ideas.
3. Confusion: People with alcoholic psychosis may experience confusion about their surroundings, events, or people in their lives.
4. Memory loss: Alcoholic psychosis can cause short-term memory loss, difficulty with concentration, and difficulty learning new information.
5. Psychomotor agitation: People with alcoholic psychosis may exhibit agitated behavior, such as pacing, restlessness, or irritability.
6. Catatonia: In severe cases of alcoholic psychosis, people may exhibit catatonic symptoms, such as immobility, mutism, or negativism (resisting instructions or commands).

Diagnosis:

1. Physical examination: A healthcare professional will perform a physical examination to rule out other medical conditions that may cause similar symptoms.
2. Medical history: The healthcare professional will ask questions about the person's medical history, including their alcohol use and any previous psychotic episodes.
3. Mental status evaluation: The healthcare professional will evaluate the person's mental status, including their cognitive function, memory, and thought processes.
4. Laboratory tests: The healthcare professional may order laboratory tests to rule out other medical conditions that may cause similar symptoms.
5. Imaging studies: The healthcare professional may order imaging studies, such as a CT or MRI scan, to rule out other medical conditions that may cause similar symptoms.

Treatment:

1. Hospitalization: People with alcoholic psychosis are often hospitalized for their own safety and the safety of others.
2. Detoxification: The person will undergo detoxification to remove alcohol from their body.
3. Antipsychotic medications: The healthcare professional may prescribe antipsychotic medications to reduce the severity of symptoms.
4. Antidepressant medications: The healthcare professional may prescribe antidepressant medications to help manage depressive symptoms.
5. Counseling and therapy: The person will receive counseling and therapy to address their alcohol use disorder and any co-occurring mental health conditions.
6. Family support: The healthcare professional may involve the person's family in their treatment, as they can provide valuable support and help with recovery.
7. Follow-up care: The healthcare professional will follow up with the person to monitor their progress and make any necessary adjustments to their treatment plan.

Prognosis:
The prognosis for alcoholic psychosis is generally good if the person receives prompt and appropriate treatment. However, the condition can be challenging to treat, and recovery may take time. It is essential for the person to stay in treatment and follow their healthcare professional's recommendations to achieve the best possible outcome.

Complications:
Alcoholic psychosis can have several complications, including:

1. Suicide: People with alcoholic psychosis are at a higher risk of suicide due to their underlying mental health conditions and the stress of dealing with the condition.
2. Seizures: Alcohol withdrawal seizures can occur in people who suddenly stop drinking alcohol.
3. Dementia: Chronic alcohol consumption can cause permanent damage to the brain, leading to dementia.
4. Liver disease: Long-term heavy drinking can lead to liver disease, which can be life-threatening.
5. Heart disease: Excessive alcohol consumption can increase the risk of heart disease and stroke.
6. Nutritional deficiencies: Alcohol can interfere with the body's ability to absorb nutrients, leading to deficiencies in vitamins and minerals.
7. Social problems: Alcoholic psychosis can cause significant social problems, including strained relationships, financial difficulties, and legal issues.

Prevention:
Preventing alcoholic psychosis is essential, as it can be challenging to treat once it has developed. Some ways to prevent the condition include:

1. Avoiding excessive alcohol consumption: Limiting alcohol intake to moderate levels (up to one drink per day for women and up to two drinks per day for men) can reduce the risk of developing alcoholic psychosis.
2. Seeking professional help: If you or someone you know is struggling with alcohol addiction, seeking professional help from a mental health professional or a substance abuse treatment center can be beneficial.
3. Maintaining a healthy lifestyle: Engaging in regular exercise, eating a balanced diet, and getting enough sleep can help reduce the risk of developing alcoholic psychosis.
4. Avoiding triggers: Identifying and avoiding triggers that may cause you to drink excessively can help prevent the development of alcoholic psychosis.
5. Support groups: Joining a support group, such as Alcoholics Anonymous (AA), can provide a supportive community and resources for individuals struggling with alcohol addiction.

Treatment:
If you or someone you know is experiencing symptoms of alcoholic psychosis, it is essential to seek professional help immediately. Treatment options may include:

1. Hospitalization: In severe cases of alcoholic psychosis, hospitalization may be necessary to ensure the individual's safety and provide appropriate care.
2. Medications: Antipsychotic medications, such as risperidone or olanzapine, may be prescribed to manage symptoms of alcoholic psychosis.
3. Therapy: Cognitive-behavioral therapy (CBT) and other forms of talk therapy can help individuals understand the underlying causes of their addiction and develop strategies for maintaining sobriety.
4. Support groups: Joining a support group, such as Alcoholics Anonymous (AA), can provide a supportive community and resources for individuals recovering from alcoholic psychosis.
5. Lifestyle changes: Making lifestyle changes, such as avoiding triggers, engaging in regular exercise, and maintaining a healthy diet, can help individuals recovering from alcoholic psychosis maintain their sobriety and reduce the risk of relapse.

Some common types of movement disorders include:

1. Parkinson's disease: A degenerative disorder characterized by tremors, rigidity, bradykinesia, and postural instability.
2. Dystonia: A movement disorder characterized by sustained or intermittent muscle contractions that cause abnormal postures or movements.
3. Huntington's disease: An inherited disorder that causes progressive damage to the brain, leading to involuntary movements, cognitive decline, and psychiatric symptoms.
4. Tourette syndrome: A neurodevelopmental disorder characterized by repetitive, involuntary movements and vocalizations (tics).
5. Restless leg syndrome: A condition characterized by an uncomfortable sensation in the legs, often described as a creeping or crawling feeling, which is relieved by movement.
6. Chorea: A movement disorder characterized by rapid, jerky movements that can be triggered by emotional stress or other factors.
7. Ballism: Excessive, large, and often circular movements of the limbs, often seen in conditions such as Huntington's disease or drug-induced movements.
8. Athetosis: A slow, writhing movement that can be seen in conditions such as cerebral palsy or tardive dyskinesia.
9. Myoclonus: Sudden, brief muscle jerks or twitches that can be caused by a variety of factors, including genetic disorders, infections, and certain medications.
10. Hyperkinesis: An excessive amount of movement, often seen in conditions such as attention deficit hyperactivity disorder (ADHD) or hyperthyroidism.

Movement disorders can significantly impact an individual's quality of life, and treatment options vary depending on the specific condition and its underlying cause. Some movement disorders may be managed with medication, while others may require surgery or other interventions.

Disease progression can be classified into several types based on the pattern of worsening:

1. Chronic progressive disease: In this type, the disease worsens steadily over time, with a gradual increase in symptoms and decline in function. Examples include rheumatoid arthritis, osteoarthritis, and Parkinson's disease.
2. Acute progressive disease: This type of disease worsens rapidly over a short period, often followed by periods of stability. Examples include sepsis, acute myocardial infarction (heart attack), and stroke.
3. Cyclical disease: In this type, the disease follows a cycle of worsening and improvement, with periodic exacerbations and remissions. Examples include multiple sclerosis, lupus, and rheumatoid arthritis.
4. Recurrent disease: This type is characterized by episodes of worsening followed by periods of recovery. Examples include migraine headaches, asthma, and appendicitis.
5. Catastrophic disease: In this type, the disease progresses rapidly and unpredictably, with a poor prognosis. Examples include cancer, AIDS, and organ failure.

Disease progression can be influenced by various factors, including:

1. Genetics: Some diseases are inherited and may have a predetermined course of progression.
2. Lifestyle: Factors such as smoking, lack of exercise, and poor diet can contribute to disease progression.
3. Environmental factors: Exposure to toxins, allergens, and other environmental stressors can influence disease progression.
4. Medical treatment: The effectiveness of medical treatment can impact disease progression, either by slowing or halting the disease process or by causing unintended side effects.
5. Co-morbidities: The presence of multiple diseases or conditions can interact and affect each other's progression.

Understanding the type and factors influencing disease progression is essential for developing effective treatment plans and improving patient outcomes.

There are several types of gliomas, including:

1. Astrocytoma: This is the most common type of glioma, accounting for about 50% of all cases. It arises from the star-shaped cells called astrocytes that provide support and nutrients to the brain's nerve cells.
2. Oligodendroglioma: This type of glioma originates from the oligodendrocytes, which are responsible for producing the fatty substance called myelin that insulates the nerve fibers.
3. Glioblastoma (GBM): This is the most aggressive and malignant type of glioma, accounting for about 70% of all cases. It is fast-growing and often spreads to other parts of the brain.
4. Brain stem glioma: This type of glioma arises in the brain stem, which is responsible for controlling many of the body's vital functions such as breathing, heart rate, and blood pressure.

The symptoms of glioma depend on the location and size of the tumor. Common symptoms include headaches, seizures, weakness or numbness in the arms or legs, and changes in personality, memory, or speech.

Gliomas are diagnosed through a combination of imaging tests such as CT or MRI scans, and tissue biopsy to confirm the presence of cancer cells. Treatment options for glioma depend on the type and location of the tumor, as well as the patient's overall health. Surgery is often the first line of treatment to remove as much of the tumor as possible, followed by radiation therapy and/or chemotherapy to kill any remaining cancer cells.

The prognosis for glioma patients varies depending on the type and location of the tumor, as well as the patient's overall health. In general, the prognosis is better for patients with slow-growing, low-grade tumors, while those with fast-growing, high-grade tumors have a poorer prognosis. Overall, the 5-year survival rate for glioma patients is around 30-40%.

Intracranial hematoma occurs within the skull and is often caused by head injuries, such as falls or car accidents. It can lead to severe neurological symptoms, including confusion, seizures, and loss of consciousness. Extracranial hematomas occur outside the skull and are commonly seen in injuries from sports, accidents, or surgery.

The signs and symptoms of hematoma may vary depending on its location and size. Common symptoms include pain, swelling, bruising, and limited mobility. Diagnosis is typically made through imaging tests such as CT scans or MRI scans, along with physical examination and medical history.

Treatment for hematoma depends on its severity and location. In some cases, conservative management with rest, ice, compression, and elevation (RICE) may be sufficient. However, surgical intervention may be necessary to drain the collection of blood or remove any clots that have formed.

In severe cases, hematoma can lead to life-threatening complications such as infection, neurological damage, and organ failure. Therefore, prompt medical attention is crucial for proper diagnosis and treatment.

1. Respiratory distress syndrome (RDS): This is a breathing disorder that occurs when the baby's lungs are not fully developed, causing difficulty in breathing. RDS can be treated with oxygen therapy and other medical interventions.
2. Jaundice: Jaundice is a yellowish tint to the skin and eyes caused by high levels of bilirubin in the blood. It is a common condition in newborns, but if left untreated, it can lead to brain damage. Treatment may involve phototherapy or blood exchange transfusions.
3. Neonatal jaundice: This is a milder form of jaundice that occurs in the first few days of life. It usually resolves on its own within a week, but if it persists, treatment may be necessary.
4. Premature birth: Premature babies are at risk for various health issues, including respiratory distress syndrome, intraventricular hemorrhage (bleeding in the brain), and retinopathy (eye problems).
5. Congenital heart disease: This is a heart defect that occurs during fetal development. It can range from mild to severe and may require surgical intervention.
6. Infections: Newborns are susceptible to bacterial and viral infections, such as group B strep, pneumonia, and urinary tract infections. These can be treated with antibiotics if caught early.
7. Hypoglycemia (low blood sugar): This is a condition that occurs when the baby's blood sugar levels drop too low. It can cause seizures, lethargy, and other symptoms. Treatment involves feeding or providing glucose supplements.
8. Hyperbilirubinemia (high bilirubin levels): Bilirubin is a yellow pigment produced during the breakdown of red blood cells. High levels can cause jaundice, which can lead to kernicterus, a condition that can cause brain damage and hearing loss.
9. Intracranial hemorrhage (bleeding in the brain): This is a serious condition that occurs when there is bleeding in the baby's brain. It can be caused by various conditions, including premature birth, abruption, and vasculitis.
10. Meconium aspiration: This occurs when the baby inhales a mixture of meconium (a substance produced by the intestines) and amniotic fluid during delivery. It can cause respiratory problems and other complications.

It's important to note that while these conditions can be serious, many babies born at 37 weeks gestation do not experience any complications. Proper prenatal care and a healthy pregnancy can help reduce the risk of these conditions.

Symptoms of Sturge-Weber Syndrome can vary in severity and may include:

* Port-wine stain (nevus flammeus) on one side of the face and/or neck
* Seizures, including epilepsy
* Developmental delays and intellectual disability
* Vision problems, including glaucoma, cataracts, and visual field defects
* Hearing loss
* Scoliosis or other spinal abnormalities
* Weakened muscles (hypotonia)

There is no cure for Sturge-Weber Syndrome, but various treatments can help manage the symptoms. These may include:

* Anticonvulsant medications to control seizures
* Surgery to remove the port-wine stain or repair related eye problems
* Physical therapy to improve muscle strength and coordination
* Speech and language therapy to address communication difficulties
* Occupational therapy to help with daily living skills

The prognosis for Sturge-Weber Syndrome varies depending on the severity of the disorder and the presence of other health problems. Some individuals with the condition may have a relatively mild course, while others may experience more significant challenges. With appropriate medical care and support, many individuals with Sturge-Weber Syndrome can lead fulfilling lives.

Types of cerebral arterial diseases include:

1. Cerebral vasospasm: A temporary constriction of the blood vessels in the brain, often seen after subarachnoid hemorrhage (bleeding in the space surrounding the brain).
2. Moyamoya disease: A rare condition caused by narrowing or blockage of the internal carotid artery and its branches, leading to decreased blood flow to the brain.
3. Cerebral amyloid angiopathy: A condition in which abnormal protein deposits accumulate in the walls of blood vessels supplying the brain, leading to inflammation and damage.
4. Cerebral infarction (stroke): The loss of brain tissue due to reduced blood flow or a blockage in an artery supplying the brain.
5. Cerebral hemorrhage: Bleeding in the brain, often due to rupture of a blood vessel or aneurysm.

Symptoms of cerebral arterial diseases can vary depending on the location and severity of the affected blood vessels, but may include headache, confusion, weakness or numbness in the face or limbs, difficulty speaking or understanding speech, and vision problems.

Diagnosis of cerebral arterial diseases typically involves a combination of physical examination, medical history, neuroimaging studies (such as CT or MRI scans), and angiography (a test that uses dye and X-rays to visualize the blood vessels in the brain).

Treatment options for cerebral arterial diseases depend on the underlying cause and severity of the condition, but may include medications to control blood pressure, cholesterol levels, or inflammation, as well as surgical interventions such as endarterectomy (removing plaque from the affected blood vessel) or aneurysm repair. In some cases, cerebral arterial diseases may be treated with a combination of medical and surgical therapies.

Complications of cerebral arterial diseases can include stroke, seizures, and cognitive decline. With prompt and appropriate treatment, however, many individuals with cerebral arterial diseases can experience significant improvement in symptoms and quality of life.

The Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) defines alcohol use disorder as a maladaptive pattern of alcohol use that leads to clinically significant impairment or distress in at least three of the following areas:

1. Drinking more or for longer than intended.
2. Desire or unsuccessful efforts to cut down or control drinking.
3. Spending a lot of time drinking or recovering from its effects.
4. Craving or strong desire to drink.
5. Drinking interferes with work, school, or home responsibilities.
6. Continuing to drink despite social or personal problems caused by alcohol use.
7. Giving up important activities in order to drink.
8. Drinking in hazardous situations (e.g., while driving).
9. Continued drinking despite physical or psychological problems caused or worsened by alcohol use.
10. Developing tolerance (i.e., needing to drink more to achieve the desired effect).
11. Experiencing withdrawal symptoms when alcohol use is stopped or reduced.

The severity of alcoholism is categorized into three subtypes based on the number of criteria met: mild, moderate, and severe. Treatment for alcoholism typically involves a combination of behavioral interventions (e.g., cognitive-behavioral therapy, motivational interviewing) and medications (e.g., disulfiram, naltrexone, acamprosate) to manage withdrawal symptoms and cravings.

In conclusion, alcoholism is a chronic and often progressive disease characterized by excessive and compulsive consumption of alcohol despite negative consequences to physical and mental health, relationships, and social functioning. The diagnostic criteria for alcoholism include a combination of physiological, behavioral, and subjective symptoms, and treatment typically involves a combination of behavioral interventions and medications to manage withdrawal symptoms and cravings.

Hypothermia can be mild, moderate, or severe. Mild hypothermia is characterized by shivering and a body temperature of 95 to 97 degrees Fahrenheit (32 to 36.1 degrees Celsius). Moderate hypothermia has a body temperature of 82 to 94 degrees Fahrenheit (28 to 34 degrees Celsius), and the person may appear lethargic, drowsy, or confused. Severe hypothermia is characterized by a body temperature below 82 degrees Fahrenheit (28 degrees Celsius) and can lead to coma and even death if not treated promptly.

Treatment for hypothermia typically involves warming the person up slowly, using blankets or heating pads, and providing warm fluids to drink. In severe cases, medical professionals may use a specialized warm water bath or apply warm packs to specific areas of the body.

Preventing hypothermia is important, especially in cold weather conditions. This can be done by dressing appropriately for the weather, staying dry and avoiding wet clothing, eating regularly to maintain energy levels, and seeking shelter if you become stranded or lost. It's also essential to recognize the signs of hypothermia early on so that treatment can begin promptly.

Epidemiology:
Febrile seizures are relatively common in children under the age of five. They affect approximately 2-5% of children in this age group and account for nearly one-third of all seizures in childhood. Febrile seizures are more common in boys than girls and tend to occur more frequently between 12 and 18 months of age.

Causes:
The exact cause of febrile seizures is not known, but they are believed to be triggered by a rapid increase in body temperature. This can occur due to an infection such as a viral or bacterial infection, or due to other factors such as dehydration or an allergic reaction.

Symptoms:
During a febrile seizure, the child may experience a variety of symptoms including:

* Convulsions or shaking of the arms and legs
* Loss of consciousness or confusion
* Stiffness or rigidity of the body
* Confusion or disorientation after the seizure has ended

Diagnosis:
Febrile seizures are typically diagnosed based on a combination of symptoms and medical history. A doctor may perform a physical examination and order additional tests such as blood work or imaging studies to rule out other conditions that could be causing the fever and seizure.

Treatment:
There is no specific treatment for febrile seizures, but there are steps parents can take to help their child feel more comfortable and reduce the risk of future seizures. These include:

* Providing plenty of fluids to prevent dehydration
* Keeping the child cool with a cool compress or bath
* Medications such as acetaminophen or ibuprofen to reduce fever
* Home remedies such as ginger or chamomile tea to help soothe the child and reduce inflammation

Prevention:
While there is no surefire way to prevent febrile seizures, parents can take steps to reduce the risk of their child experiencing one. These include:

* Keeping the child's immunizations up to date to prevent infections that can cause fever and seizures
* Monitoring the child's temperature and seeking medical attention if it reaches 104°F (40°C) or higher
* Providing plenty of fluids to prevent dehydration
* Avoiding overdressing the child and keeping them in a cool, well-ventilated environment to prevent overheating

Prognosis:
In most cases, febrile seizures are not a cause for concern and do not indicate any underlying medical condition. However, if your child experiences a second seizure or if the first seizure lasts for more than 15 minutes, it is important to seek immediate medical attention. Additionally, if your child has a fever that does not come down with treatment or if they experience other symptoms such as stiffness or confusion, you should also seek medical help.

In rare cases, febrile seizures can be a sign of a more serious underlying condition such as a brain infection or a congenital disorder. Therefore, it is important to be aware of the signs and symptoms of these conditions and to seek medical attention if you suspect that your child may have one.

In conclusion, while febrile seizures can be alarming for parents, they are generally not a cause for concern and can be treated effectively with home remedies and over-the-counter medications. However, it is important to be aware of the signs and symptoms of more serious underlying conditions and to seek medical attention if you suspect that your child may have one.

Prenatal Exposure Delayed Effects can affect various aspects of the child's development, including:

1. Physical growth and development: PDEDs can lead to changes in the child's physical growth patterns, such as reduced birth weight, short stature, or delayed puberty.
2. Brain development: Prenatal exposure to certain substances can affect brain development, leading to learning disabilities, memory problems, and cognitive delays.
3. Behavioral and emotional development: Children exposed to PDEDs may exhibit behavioral and emotional difficulties, such as anxiety, depression, or attention deficit hyperactivity disorder (ADHD).
4. Immune system functioning: Prenatal exposure to certain substances can affect the immune system's development, making children more susceptible to infections and autoimmune diseases.
5. Reproductive health: Exposure to certain chemicals during fetal development may disrupt the reproductive system, leading to fertility problems or an increased risk of infertility later in life.

The diagnosis of Prenatal Exposure Delayed Effects often requires a comprehensive medical history and physical examination, as well as specialized tests such as imaging studies or laboratory assessments. Treatment for PDEDs typically involves addressing the underlying cause of exposure and providing appropriate interventions to manage any associated symptoms or developmental delays.

In summary, Prenatal Exposure Delayed Effects can have a profound impact on a child's growth, development, and overall health later in life. It is essential for healthcare providers to be aware of the potential risks and to monitor children exposed to substances during fetal development for any signs of PDEDs. With early diagnosis and appropriate interventions, it may be possible to mitigate or prevent some of these effects and improve outcomes for affected children.

Examples of fetal diseases include:

1. Down syndrome: A genetic disorder caused by an extra copy of chromosome 21, which can cause delays in physical and intellectual development, as well as increased risk of heart defects and other health problems.
2. Spina bifida: A birth defect that affects the development of the spine and brain, resulting in a range of symptoms from mild to severe.
3. Cystic fibrosis: A genetic disorder that affects the respiratory and digestive systems, causing thick mucus buildup and recurring lung infections.
4. Anencephaly: A condition where a portion of the brain and skull are missing, which is usually fatal within a few days or weeks of birth.
5. Clubfoot: A deformity of the foot and ankle that can be treated with casts or surgery.
6. Hirschsprung's disease: A condition where the nerve cells that control bowel movements are missing, leading to constipation and other symptoms.
7. Diaphragmatic hernia: A birth defect that occurs when there is a hole in the diaphragm, allowing organs from the abdomen to move into the chest cavity.
8. Gastroschisis: A birth defect where the intestines protrude through a opening in the abdominal wall.
9. Congenital heart disease: Heart defects that are present at birth, such as holes in the heart or narrowed blood vessels.
10. Neural tube defects: Defects that affect the brain and spine, such as spina bifida and anencephaly.

Early detection and diagnosis of fetal diseases can be crucial for ensuring proper medical care and improving outcomes for affected babies. Prenatal testing, such as ultrasound and blood tests, can help identify fetal anomalies and genetic disorders during pregnancy.

Types of Arterial Occlusive Diseases:

1. Atherosclerosis: Atherosclerosis is a condition where plaque builds up inside the arteries, leading to narrowing or blockages that can restrict blood flow to certain areas of the body.
2. Peripheral Artery Disease (PAD): PAD is a condition where the blood vessels in the legs and arms become narrowed or blocked, leading to pain or cramping in the affected limbs.
3. Coronary Artery Disease (CAD): CAD is a condition where the coronary arteries, which supply blood to the heart, become narrowed or blocked, leading to chest pain or a heart attack.
4. Carotid Artery Disease: Carotid artery disease is a condition where the carotid arteries, which supply blood to the brain, become narrowed or blocked, leading to stroke or mini-stroke.
5. Renal Artery Stenosis: Renal artery stenosis is a condition where the blood vessels that supply the kidneys become narrowed or blocked, leading to high blood pressure and decreased kidney function.

Symptoms of Arterial Occlusive Diseases:

1. Pain or cramping in the affected limbs
2. Weakness or fatigue
3. Difficulty walking or standing
4. Chest pain or discomfort
5. Shortness of breath
6. Dizziness or lightheadedness
7. Stroke or mini-stroke

Treatment for Arterial Occlusive Diseases:

1. Medications: Medications such as blood thinners, cholesterol-lowering drugs, and blood pressure medications may be prescribed to treat arterial occlusive diseases.
2. Lifestyle Changes: Lifestyle changes such as quitting smoking, exercising regularly, and eating a healthy diet can help manage symptoms and slow the progression of the disease.
3. Endovascular Procedures: Endovascular procedures such as angioplasty and stenting may be performed to open up narrowed or blocked blood vessels.
4. Surgery: In some cases, surgery may be necessary to treat arterial occlusive diseases, such as bypass surgery or carotid endarterectomy.

Prevention of Arterial Occlusive Diseases:

1. Maintain a healthy diet and lifestyle
2. Quit smoking and avoid exposure to secondhand smoke
3. Exercise regularly
4. Manage high blood pressure, high cholesterol, and diabetes
5. Avoid excessive alcohol consumption
6. Get regular check-ups with your healthcare provider

Early detection and treatment of arterial occlusive diseases can help manage symptoms, slow the progression of the disease, and prevent complications such as heart attack or stroke.

There are several types of apnea that can occur during sleep, including:

1. Obstructive sleep apnea (OSA): This is the most common type of apnea and occurs when the airway is physically blocked by the tongue or other soft tissue in the throat, causing breathing to stop for short periods.
2. Central sleep apnea (CSA): This type of apnea occurs when the brain fails to send the proper signals to the muscles that control breathing, resulting in a pause in breathing.
3. Mixed sleep apnea (MSA): This type of apnea is a combination of OSA and CSA, where both central and obstructive factors contribute to the pauses in breathing.
4. Hypopneic apnea: This type of apnea is characterized by a decrease in breathing, but not a complete stop.
5. Hypercapnic apnea: This type of apnea is caused by an excessive buildup of carbon dioxide in the blood, which can lead to pauses in breathing.

The symptoms of apnea can vary depending on the type and severity of the condition, but may include:

* Pauses in breathing during sleep
* Waking up with a dry mouth or sore throat
* Morning headaches
* Difficulty concentrating or feeling tired during the day
* High blood pressure
* Heart disease

Treatment options for apnea depend on the underlying cause, but may include:

* Lifestyle changes, such as losing weight, avoiding alcohol and sedatives before bedtime, and sleeping on your side
* Oral appliances or devices that advance the position of the lower jaw and tongue
* Continuous positive airway pressure (CPAP) therapy, which involves wearing a mask during sleep to deliver a constant flow of air pressure into the airways
* Bi-level positive airway pressure (BiPAP) therapy, which involves two levels of air pressure: one for inhalation and another for exhalation
* Surgery to remove excess tissue in the throat or correct physical abnormalities that are contributing to the apnea.

There are many different types of epilepsy, each with its own unique set of symptoms and characteristics. Some common forms of epilepsy include:

1. Generalized Epilepsy: This type of epilepsy affects both sides of the brain and can cause a range of seizure types, including absence seizures, tonic-clonic seizures, and atypical absence seizures.
2. Focal Epilepsy: This type of epilepsy affects only one part of the brain and can cause seizures that are localized to that area. There are several subtypes of focal epilepsy, including partial seizures with complex symptoms and simple partial seizures.
3. Tonic-Clonic Epilepsy: This type of epilepsy is also known as grand mal seizures and can cause a loss of consciousness, convulsions, and muscle stiffness.
4. Lennox-Gastaut Syndrome: This is a rare and severe form of epilepsy that typically develops in early childhood and can cause multiple types of seizures, including tonic, atonic, and myoclonic seizures.
5. Dravet Syndrome: This is a rare genetic form of epilepsy that typically develops in infancy and can cause severe, frequent seizures.
6. Rubinstein-Taybi Syndrome: This is a rare genetic disorder that can cause intellectual disability, developmental delays, and various types of seizures.
7. Other forms of epilepsy include Absence Epilepsy, Myoclonic Epilepsy, and Atonic Epilepsy.

The symptoms of epilepsy can vary widely depending on the type of seizure disorder and the individual affected. Some common symptoms of epilepsy include:

1. Seizures: This is the most obvious symptom of epilepsy and can range from mild to severe.
2. Loss of consciousness: Some people with epilepsy may experience a loss of consciousness during a seizure, while others may remain aware of their surroundings.
3. Confusion and disorientation: After a seizure, some people with epilepsy may feel confused and disoriented.
4. Memory loss: Seizures can cause short-term or long-term memory loss.
5. Fatigue: Epilepsy can cause extreme fatigue, both during and after a seizure.
6. Emotional changes: Some people with epilepsy may experience emotional changes, such as anxiety, depression, or mood swings.
7. Cognitive changes: Epilepsy can affect cognitive function, including attention, memory, and learning.
8. Sleep disturbances: Some people with epilepsy may experience sleep disturbances, such as insomnia or sleepiness.
9. Physical symptoms: Depending on the type of seizure, people with epilepsy may experience physical symptoms such as muscle weakness, numbness or tingling, and sensory changes.
10. Social isolation: Epilepsy can cause social isolation due to fear of having a seizure in public or stigma associated with the condition.

It's important to note that not everyone with epilepsy will experience all of these symptoms, and some people may have different symptoms depending on the type of seizure they experience. Additionally, some people with epilepsy may experience additional symptoms not listed here.

There are several causes of hypotension, including:

1. Dehydration: Loss of fluids and electrolytes can cause a drop in blood pressure.
2. Blood loss: Losing too much blood can lead to hypotension.
3. Medications: Certain medications, such as diuretics and beta-blockers, can lower blood pressure.
4. Heart conditions: Heart failure, cardiac tamponade, and arrhythmias can all cause hypotension.
5. Endocrine disorders: Hypothyroidism (underactive thyroid) and adrenal insufficiency can cause low blood pressure.
6. Vasodilation: A condition where the blood vessels are dilated, leading to low blood pressure.
7. Sepsis: Severe infection can cause hypotension.

Symptoms of hypotension can include:

1. Dizziness and lightheadedness
2. Fainting or passing out
3. Weakness and fatigue
4. Confusion and disorientation
5. Pale, cool, or clammy skin
6. Fast or weak pulse
7. Shortness of breath
8. Nausea and vomiting

If you suspect that you or someone else is experiencing hypotension, it is important to seek medical attention immediately. Treatment will depend on the underlying cause of the condition, but may include fluids, electrolytes, and medication to raise blood pressure. In severe cases, hospitalization may be necessary.

1. Atrial fibrillation (a type of irregular heartbeat)
2. Heart disease or valve problems
3. Blood clots in the legs or lungs
4. Infective endocarditis (an infection of the heart valves)
5. Cancer and its treatment
6. Trauma to the head or neck
7. High blood pressure
8. Atherosclerosis (the buildup of plaque in the arteries)

When a blockage occurs in one of the blood vessels of the brain, it can deprive the brain of oxygen and nutrients, leading to cell death and potentially causing a range of symptoms including:

1. Sudden weakness or numbness in the face, arm, or leg
2. Sudden confusion or trouble speaking or understanding speech
3. Sudden trouble seeing in one or both eyes
4. Sudden severe headache
5. Dizziness or loss of balance
6. Fainting or falling

Intracranial embolism and thrombosis can be diagnosed through a variety of imaging tests, including:

1. Computed tomography (CT) scan
2. Magnetic resonance imaging (MRI)
3. Magnetic resonance angiography (MRA)
4. Cerebral angiography
5. Doppler ultrasound

Treatment options for intracranial embolism and thrombosis depend on the underlying cause of the blockage, but may include:

1. Medications to dissolve blood clots or prevent further clotting
2. Surgery to remove the blockage or repair the affected blood vessel
3. Endovascular procedures, such as angioplasty and stenting, to open up narrowed or blocked blood vessels
4. Supportive care, such as oxygen therapy and pain management, to help manage symptoms and prevent complications.

The symptoms of MS can vary widely depending on the location and severity of the damage to the CNS. Common symptoms include:

* Weakness, numbness, or tingling in the limbs
* Fatigue
* Vision problems, such as blurred vision, double vision, or loss of vision
* Difficulty with balance and coordination
* Tremors or spasticity
* Memory and concentration problems
* Mood changes, such as depression or mood swings
* Bladder and bowel problems

There is no cure for MS, but various treatments can help manage the symptoms and slow the progression of the disease. These treatments include:

* Disease-modifying therapies (DMTs) - These medications are designed to reduce the frequency and severity of relapses, and they can also slow the progression of disability. Examples of DMTs include interferons, glatiramer acetate, natalizumab, fingolimod, dimethyl fumarate, teriflunomide, and alemtuzumab.
* Steroids - Corticosteroids can help reduce inflammation during relapses, but they are not a long-term solution.
* Pain management medications - Pain relievers, such as acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs), can help manage pain caused by MS.
* Muscle relaxants - These medications can help reduce spasticity and tremors.
* Physical therapy - Physical therapy can help improve mobility, balance, and strength.
* Occupational therapy - Occupational therapy can help with daily activities and assistive devices.
* Speech therapy - Speech therapy can help improve communication and swallowing difficulties.
* Psychological counseling - Counseling can help manage the emotional and psychological aspects of MS.

It's important to note that each person with MS is unique, and the best treatment plan will depend on the individual's specific symptoms, needs, and preferences. It's essential to work closely with a healthcare provider to find the most effective treatment plan.

Body weight is an important health indicator, as it can affect an individual's risk for certain medical conditions, such as obesity, diabetes, and cardiovascular disease. Maintaining a healthy body weight is essential for overall health and well-being, and there are many ways to do so, including a balanced diet, regular exercise, and other lifestyle changes.

There are several ways to measure body weight, including:

1. Scale: This is the most common method of measuring body weight, and it involves standing on a scale that displays the individual's weight in kg or lb.
2. Body fat calipers: These are used to measure body fat percentage by pinching the skin at specific points on the body.
3. Skinfold measurements: This method involves measuring the thickness of the skin folds at specific points on the body to estimate body fat percentage.
4. Bioelectrical impedance analysis (BIA): This is a non-invasive method that uses electrical impulses to measure body fat percentage.
5. Dual-energy X-ray absorptiometry (DXA): This is a more accurate method of measuring body composition, including bone density and body fat percentage.

It's important to note that body weight can fluctuate throughout the day due to factors such as water retention, so it's best to measure body weight at the same time each day for the most accurate results. Additionally, it's important to use a reliable scale or measuring tool to ensure accurate measurements.

Other definitions:

* Premature birth: A birth that occurs before 37 completed weeks of gestation.
* Preterm birth: A birth that occurs before 37 completed weeks of gestation, but not necessarily before 22 weeks.
* Very preterm birth: A birth that occurs before 28 completed weeks of gestation.
* Extremely preterm birth: A birth that occurs before 24 completed weeks of gestation.

Diseases associated with premature infants:

1. Respiratory distress syndrome (RDS): A condition in which the baby's lungs do not produce enough surfactant, a substance that helps the air sacs in the lungs expand and contract properly.
2. Bronchopulmonary dysplasia (BPD): A chronic lung disease that can develop in premature infants who have RDS.
3. Intraventricular hemorrhage (IVH): Bleeding in the brain that can occur in premature infants, particularly those with RDS or BPD.
4. Retinopathy of prematurity (ROP): A condition that can cause blindness in premature infants due to abnormal blood vessel growth in the retina.
5. Necrotizing enterocolitis (NEC): A condition that can cause damage to the intestines and other parts of the digestive system in premature infants.
6. Intracranial hemorrhage (ICH): Bleeding in the brain that can occur in premature infants, particularly those with RDS or BPD.
7. Gastrointestinal problems: Premature infants are at risk for gastroesophageal reflux disease (GERD), necrotizing enterocolitis (NEC), and other gastrointestinal problems.
8. Feeding difficulties: Premature infants may have difficulty feeding, which can lead to weight gain issues or the need for a feeding tube.
9. Respiratory infections: Premature infants are at increased risk for respiratory infections, such as pneumonia and bronchiolitis.
10. Developmental delays: Premature infants may be at risk for developmental delays or learning disabilities, particularly if they experienced significant health problems or required oxygen therapy.

It is important to note that not all premature infants will develop these complications, and the severity of the conditions can vary depending on the individual baby's health and the level of care they receive. However, it is essential for parents and caregivers to be aware of the potential risks and seek prompt medical attention if they notice any signs of distress or illness in their premature infant.

Hyponatremia can be caused by various factors, such as excessive fluid intake, certain medications, kidney or liver disease, and hormonal imbalances. Symptoms may include headache, nausea, vomiting, fatigue, muscle weakness, and in severe cases, seizures or coma.

Treatment for hyponatremia typically involves correcting the underlying cause of the condition. This may involve discontinuing certain medications, addressing any underlying medical conditions, or limiting fluid intake. In severe cases, hospitalization may be necessary to monitor and treat the condition. In some instances, sodium supplements or diuretics may be prescribed to help correct sodium levels.

It is important to note that hyponatremia can be a serious condition, and prompt medical attention should be sought if symptoms persist or worsen over time. A healthcare professional should be consulted for proper diagnosis and treatment.

There are several types of ischemia, including:

1. Myocardial ischemia: Reduced blood flow to the heart muscle, which can lead to chest pain or a heart attack.
2. Cerebral ischemia: Reduced blood flow to the brain, which can lead to stroke or cognitive impairment.
3. Peripheral arterial ischemia: Reduced blood flow to the legs and arms.
4. Renal ischemia: Reduced blood flow to the kidneys.
5. Hepatic ischemia: Reduced blood flow to the liver.

Ischemia can be diagnosed through a variety of tests, including electrocardiograms (ECGs), stress tests, and imaging studies such as CT or MRI scans. Treatment for ischemia depends on the underlying cause and may include medications, lifestyle changes, or surgical interventions.

Examples of acute diseases include:

1. Common cold and flu
2. Pneumonia and bronchitis
3. Appendicitis and other abdominal emergencies
4. Heart attacks and strokes
5. Asthma attacks and allergic reactions
6. Skin infections and cellulitis
7. Urinary tract infections
8. Sinusitis and meningitis
9. Gastroenteritis and food poisoning
10. Sprains, strains, and fractures.

Acute diseases can be treated effectively with antibiotics, medications, or other therapies. However, if left untreated, they can lead to chronic conditions or complications that may require long-term care. Therefore, it is important to seek medical attention promptly if symptoms persist or worsen over time.

There are several subtypes of astrocytoma, including:

1. Low-grade astrocytoma: These tumors grow slowly and are less aggressive. They can be treated with surgery, radiation therapy, or chemotherapy.
2. High-grade astrocytoma: These tumors grow more quickly and are more aggressive. They are often resistant to treatment and may recur after initial treatment.
3. Anaplastic astrocytoma: These are the most aggressive type of astrocytoma, growing rapidly and spreading to other parts of the brain.
4. Glioblastoma (GBM): This is the most common and deadliest type of primary brain cancer, accounting for 55% of all astrocytomas. It is highly aggressive and resistant to treatment, often recurring after initial surgery, radiation, and chemotherapy.

The symptoms of astrocytoma depend on the location and size of the tumor. Common symptoms include headaches, seizures, weakness or numbness in the arms or legs, and changes in personality or behavior.

Astrocytomas are diagnosed through a combination of imaging tests such as MRI or CT scans, and tissue biopsy. Treatment options vary depending on the type and location of the tumor, but may include surgery, radiation therapy, chemotherapy, or a combination of these.

The prognosis for astrocytoma varies based on the subtype and location of the tumor, as well as the patient's age and overall health. In general, low-grade astrocytomas have a better prognosis than high-grade tumors. However, even with treatment, the survival rate for astrocytoma is generally lower compared to other types of cancer.

The symptoms of paresis may include weakness or paralysis of specific muscle groups, loss of sensation, tremors, and difficulty with coordination and balance. The severity of the paresis can vary depending on the underlying cause and the extent of the damage to the nervous system. Treatment options for paresis depend on the underlying cause and may include physical therapy, medications, surgery, or other interventions aimed at improving motor function and preventing complications.

In summary, paresis is a loss or impairment of motor function resulting from damage to the nervous system, and can be caused by various conditions such as stroke, traumatic brain injury, and neurological disorders. Treatment options depend on the underlying cause and may include physical therapy, medications, surgery, or other interventions aimed at improving motor function and preventing complications.

Glioblastomas are highly malignant tumors that can grow rapidly and infiltrate surrounding brain tissue, making them difficult to remove surgically. They often recur after treatment and are usually fatal within a few years of diagnosis.

The symptoms of glioblastoma can vary depending on the location and size of the tumor but may include headaches, seizures, weakness or numbness in the arms or legs, and changes in personality, memory or cognitive function.

Glioblastomas are diagnosed through a combination of imaging tests such as CT or MRI scans, and a biopsy to confirm the presence of cancerous cells. Treatment typically involves surgery to remove as much of the tumor as possible, followed by radiation therapy and chemotherapy to slow the growth of any remaining cancerous cells.

Prognosis for glioblastoma is generally poor, with a five-year survival rate of around 5% for newly diagnosed patients. However, the prognosis can vary depending on factors such as the location and size of the tumor, the patient's age and overall health, and the effectiveness of treatment.

Symptoms of meningitis may include fever, headache, stiff neck, confusion, nausea and vomiting, and sensitivity to light. In severe cases, it can lead to seizures, brain damage, and even death.

There are several types of meningitis, including:

1. Viral meningitis: This is the most common form of the infection and is usually caused by enteroviruses or herpesviruses. It is typically less severe than bacterial meningitis and resolves on its own with supportive care.
2. Bacterial meningitis: This is a more serious form of the infection and can be caused by a variety of bacteria, such as Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. It requires prompt antibiotic treatment to prevent long-term complications and death.
3. Fungal meningitis: This type of meningitis is more common in people with weakened immune systems and is caused by fungi that are commonly found in the environment. It can be treated with antifungal medications.
4. Parasitic meningitis: This type of meningitis is rare and is caused by parasites that are typically found in tropical regions. It can be treated with antiparasitic medications.

Diagnosis of meningitis is based on a combination of clinical findings, laboratory tests, and imaging studies. Laboratory tests may include blood cultures, polymerase chain reaction (PCR) testing, and cerebrospinal fluid (CSF) analysis. Imaging studies, such as CT or MRI scans, may be used to rule out other conditions and to evaluate the extent of brain damage.

Treatment of meningitis depends on the cause of the infection and may include antibiotics, antiviral medications, antifungal medications, or supportive care to manage symptoms and prevent complications. Supportive care may include intravenous fluids, oxygen therapy, and pain management. In severe cases, meningitis may require hospitalization in an intensive care unit (ICU) and may result in long-term consequences such as hearing loss, learning disabilities, or cognitive impairment.

Prevention of meningitis includes vaccination against the bacteria or viruses that can cause the infection, good hygiene practices, and avoiding close contact with people who are sick. Vaccines are available for certain types of meningitis, such as the meningococcal conjugate vaccine (MenACWY) and the pneumococcal conjugate vaccine (PCV). Good hygiene practices include washing hands frequently, covering the mouth and nose when coughing or sneezing, and avoiding sharing food, drinks, or personal items.

In conclusion, meningitis is a serious and potentially life-threatening infection that can affect people of all ages. Early diagnosis and treatment are crucial to prevent long-term consequences and improve outcomes. Prevention includes vaccination, good hygiene practices, and avoiding close contact with people who are sick.



Early Postmortem Changes:

1. Cessation of metabolic processes: After death, the body's metabolic processes come to a standstill, leading to a decrease in body temperature, cellular respiration, and other physiological functions.
2. Decline in blood pressure: The heart stops pumping blood, causing a rapid decline in blood pressure.
3. Cardiac arrest: The heart stops beating, leading to a lack of oxygen supply to the body's tissues.
4. Brain death: The brain ceases to function, causing a loss of consciousness and reflexes.
5. Rigor mortis: The muscles become stiff and rigid due to the buildup of lactic acid and other metabolic byproducts.
6. Livor mortis: Blood settles in the dependent parts of the body, causing discoloration and swelling.
7. Algor mortis: The body's temperature cools, causing the skin to feel cool to the touch.

Late Postmortem Changes:

1. Decomposition: Bacteria and other microorganisms begin to break down the body's tissues, leading to putrefaction and decay.
2. Autolysis: Enzymes within the body's cells break down cellular components, causing self-digestion and softening of the tissues.
3. Lipid decomposition: Fats and oils in the body undergo oxidation, leading to the formation of offensive odors.
4. Coagulative necrosis: Blood pools in the body's tissues, causing damage to the cells and tissues.
5. Putrefaction: Bacteria in the gut and other parts of the body cause the breakdown of tissues, leading to the formation of gases and fluids.

It is important to note that postmortem changes can significantly impact the interpretation of autopsy findings and the determination of cause of death. Therefore, it is essential to consider these changes when performing an autopsy and interpreting the results.

Experimental radiation injuries are those that are intentionally caused in animal models or human subjects for research purposes, with the goal of understanding the effects of ionizing radiation on living organisms and developing treatments to mitigate these effects.

The study of experimental radiation injuries involves exposing animals or human subjects to varying levels of ionizing radiation and observing the resulting damage and recovery processes. This research has led to a better understanding of the mechanisms of radiation injury and the development of treatment strategies, such as blood transfusions and antioxidants, to mitigate the effects of radiation exposure.

Experimental radiation injuries are classified into two main types: acute and late-onset injuries. Acute radiation syndrome (ARS), also known as radiation sickness or radiation poisoning, occurs within hours to days after exposure and is characterized by nausea, vomiting, diarrhea, fatigue, and damage to the bone marrow, lungs, and gastrointestinal tract. Late-onset injuries, such as cancer and other chronic effects, can occur months or years after exposure and are caused by DNA damage and epigenetic changes.

Prevention of experimental radiation injuries is essential in reducing the risk of radiation exposure to humans and the environment. This includes using personal protective equipment, minimizing the use of ionizing radiation in medical procedures and research, and developing new technologies that reduce radiation exposure.

In summary, experimental radiation injuries are intentionally caused in animal models or human subjects for research purposes to understand the effects of ionizing radiation on living organisms and develop treatments to mitigate these effects. The study of experimental radiation injuries has led to a better understanding of the mechanisms of radiation injury and the development of treatment strategies, but prevention is essential in reducing the risk of radiation exposure.

There are different types of fever, including:

1. Pyrexia: This is the medical term for fever. It is used to describe a body temperature that is above normal, usually above 38°C (100.4°F).
2. Hyperthermia: This is a more severe form of fever, where the body temperature rises significantly above normal levels.
3. Febrile seizure: This is a seizure that occurs in children who have a high fever.
4. Remittent fever: This is a type of fever that comes and goes over a period of time.
5. Intermittent fever: This is a type of fever that recurs at regular intervals.
6. Chronic fever: This is a type of fever that persists for an extended period of time, often more than 3 weeks.

The symptoms of fever can vary depending on the underlying cause, but common symptoms include:

* Elevated body temperature
* Chills
* Sweating
* Headache
* Muscle aches
* Fatigue
* Loss of appetite

In some cases, fever can be a sign of a serious underlying condition, such as pneumonia, meningitis, or sepsis. It is important to seek medical attention if you or someone in your care has a fever, especially if it is accompanied by other symptoms such as difficulty breathing, confusion, or chest pain.

Treatment for fever depends on the underlying cause and the severity of the symptoms. In some cases, medication such as acetaminophen (paracetamol) or ibuprofen may be prescribed to help reduce the fever. It is important to follow the recommended dosage instructions carefully and to consult with a healthcare professional before giving medication to children.

In addition to medication, there are other ways to help manage fever symptoms at home. These include:

* Drinking plenty of fluids to stay hydrated
* Taking cool baths or using a cool compress to reduce body temperature
* Resting and avoiding strenuous activities
* Using over-the-counter pain relievers, such as acetaminophen (paracetamol) or ibuprofen, to help manage headache and muscle aches.

Preventive measures for fever include:

* Practicing good hygiene, such as washing your hands frequently and avoiding close contact with people who are sick
* Staying up to date on vaccinations, which can help prevent certain infections that can cause fever.

There are two types of hypertension:

1. Primary Hypertension: This type of hypertension has no identifiable cause and is also known as essential hypertension. It accounts for about 90% of all cases of hypertension.
2. Secondary Hypertension: This type of hypertension is caused by an underlying medical condition or medication. It accounts for about 10% of all cases of hypertension.

Some common causes of secondary hypertension include:

* Kidney disease
* Adrenal gland disorders
* Hormonal imbalances
* Certain medications
* Sleep apnea
* Cocaine use

There are also several risk factors for hypertension, including:

* Age (the risk increases with age)
* Family history of hypertension
* Obesity
* Lack of exercise
* High sodium intake
* Low potassium intake
* Stress

Hypertension is often asymptomatic, and it can cause damage to the blood vessels and organs over time. Some potential complications of hypertension include:

* Heart disease (e.g., heart attacks, heart failure)
* Stroke
* Kidney disease (e.g., chronic kidney disease, end-stage renal disease)
* Vision loss (e.g., retinopathy)
* Peripheral artery disease

Hypertension is typically diagnosed through blood pressure readings taken over a period of time. Treatment for hypertension may include lifestyle changes (e.g., diet, exercise, stress management), medications, or a combination of both. The goal of treatment is to reduce the risk of complications and improve quality of life.

There are several types of genomic instability, including:

1. Chromosomal instability (CIN): This refers to changes in the number or structure of chromosomes, such as aneuploidy (having an abnormal number of chromosomes) or translocations (the movement of genetic material between chromosomes).
2. Point mutations: These are changes in a single base pair in the DNA sequence.
3. Insertions and deletions: These are changes in the number of base pairs in the DNA sequence, resulting in the insertion or deletion of one or more base pairs.
4. Genomic rearrangements: These are changes in the structure of the genome, such as chromosomal breaks and reunions, or the movement of genetic material between chromosomes.

Genomic instability can arise from a variety of sources, including environmental factors, errors during DNA replication and repair, and genetic mutations. It is often associated with cancer, as cancer cells have high levels of genomic instability, which can lead to the development of resistance to chemotherapy and radiation therapy.

Research into genomic instability has led to a greater understanding of the mechanisms underlying cancer and other diseases, and has also spurred the development of new therapeutic strategies, such as targeted therapies and immunotherapies.

In summary, genomic instability is a key feature of cancer cells and is associated with various diseases, including cancer, neurodegenerative disorders, and aging. It can arise from a variety of sources and is the subject of ongoing research in the field of molecular biology.

Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1% of the population over the age of 60. It is more common in men than women and has a higher incidence in Caucasians than in other ethnic groups.

The primary symptoms of Parkinson's disease are:

* Tremors or trembling, typically starting on one side of the body
* Rigidity or stiffness, causing difficulty with movement
* Bradykinesia or slowness of movement, including a decrease in spontaneous movements such as blinking or smiling
* Postural instability, leading to falls or difficulty with balance

As the disease progresses, symptoms can include:

* Difficulty with walking, gait changes, and freezing episodes
* Dry mouth, constipation, and other non-motor symptoms
* Cognitive changes, such as dementia, memory loss, and confusion
* Sleep disturbances, including REM sleep behavior disorder
* Depression, anxiety, and other psychiatric symptoms

The exact cause of Parkinson's disease is not known, but it is believed to involve a combination of genetic and environmental factors. The disease is associated with the degradation of dopamine-producing neurons in the substantia nigra, leading to a deficiency of dopamine in the brain. This deficiency disrupts the normal functioning of the basal ganglia, a group of structures involved in movement control, leading to the characteristic symptoms of the disease.

There is no cure for Parkinson's disease, but various treatments are available to manage its symptoms. These include:

* Medications such as dopaminergic agents (e.g., levodopa) and dopamine agonists to replace lost dopamine and improve motor function
* Deep brain stimulation, a surgical procedure that involves implanting an electrode in the brain to deliver electrical impulses to specific areas of the brain
* Physical therapy to improve mobility and balance
* Speech therapy to improve communication and swallowing difficulties
* Occupational therapy to improve daily functioning

It is important for individuals with Parkinson's disease to work closely with their healthcare team to develop a personalized treatment plan that addresses their specific needs and improves their quality of life. With appropriate treatment and support, many people with Parkinson's disease are able to manage their symptoms and maintain a good level of independence for several years after diagnosis.

1. Infection: Bacterial or viral infections can develop after surgery, potentially leading to sepsis or organ failure.
2. Adhesions: Scar tissue can form during the healing process, which can cause bowel obstruction, chronic pain, or other complications.
3. Wound complications: Incisional hernias, wound dehiscence (separation of the wound edges), and wound infections can occur.
4. Respiratory problems: Pneumonia, respiratory failure, and atelectasis (collapsed lung) can develop after surgery, particularly in older adults or those with pre-existing respiratory conditions.
5. Cardiovascular complications: Myocardial infarction (heart attack), cardiac arrhythmias, and cardiac failure can occur after surgery, especially in high-risk patients.
6. Renal (kidney) problems: Acute kidney injury or chronic kidney disease can develop postoperatively, particularly in patients with pre-existing renal impairment.
7. Neurological complications: Stroke, seizures, and neuropraxia (nerve damage) can occur after surgery, especially in patients with pre-existing neurological conditions.
8. Pulmonary embolism: Blood clots can form in the legs or lungs after surgery, potentially causing pulmonary embolism.
9. Anesthesia-related complications: Respiratory and cardiac complications can occur during anesthesia, including respiratory and cardiac arrest.
10. delayed healing: Wound healing may be delayed or impaired after surgery, particularly in patients with pre-existing medical conditions.

It is important for patients to be aware of these potential complications and to discuss any concerns with their surgeon and healthcare team before undergoing surgery.

The term "schizophrenia" was first used by the Swiss psychiatrist Eugen Bleuler in 1908 to describe the splitting of mental functions, which he believed was a key feature of the disorder. The word is derived from the Greek words "schizein," meaning "to split," and "phrenos," meaning "mind."

There are several subtypes of schizophrenia, including:

1. Paranoid Schizophrenia: Characterized by delusions of persecution and suspicion, and a tendency to be hostile and defensive.
2. Hallucinatory Schizophrenia: Characterized by hearing voices or seeing things that are not there.
3. Disorganized Schizophrenia: Characterized by disorganized thinking and behavior, and a lack of motivation or interest in activities.
4. Catatonic Schizophrenia: Characterized by immobility, mutism, and other unusual movements or postures.
5. Undifferentiated Schizophrenia: Characterized by a combination of symptoms from the above subtypes.

The exact cause of schizophrenia is still not fully understood, but it is believed to involve a combination of genetic, environmental, and neurochemical factors. It is important to note that schizophrenia is not caused by poor parenting or a person's upbringing.

There are several risk factors for developing schizophrenia, including:

1. Genetics: A person with a family history of schizophrenia is more likely to develop the disorder.
2. Brain chemistry: Imbalances in neurotransmitters such as dopamine and serotonin have been linked to schizophrenia.
3. Prenatal factors: Factors such as maternal malnutrition or exposure to certain viruses during pregnancy may increase the risk of schizophrenia in offspring.
4. Childhood trauma: Traumatic events during childhood, such as abuse or neglect, have been linked to an increased risk of developing schizophrenia.
5. Substance use: Substance use has been linked to an increased risk of developing schizophrenia, particularly cannabis and other psychotic substances.

There is no cure for schizophrenia, but treatment can help manage symptoms and improve quality of life. Treatment options include:

1. Medications: Antipsychotic medications are the primary treatment for schizophrenia. They can help reduce positive symptoms such as hallucinations and delusions, and negative symptoms such as a lack of motivation or interest in activities.
2. Therapy: Cognitive-behavioral therapy (CBT) and other forms of talk therapy can help individuals with schizophrenia manage their symptoms and improve their quality of life.
3. Social support: Support from family, friends, and support groups can be an important part of the treatment plan for individuals with schizophrenia.
4. Self-care: Engaging in activities that bring pleasure and fulfillment, such as hobbies or exercise, can help individuals with schizophrenia improve their overall well-being.

It is important to note that schizophrenia is a complex condition, and treatment should be tailored to the individual's specific needs and circumstances. With appropriate treatment and support, many people with schizophrenia are able to lead fulfilling lives and achieve their goals.

1. Neurodegenerative diseases: These are diseases that cause progressive loss of brain cells, leading to cognitive decline and motor dysfunction. Examples include Alzheimer's disease, Parkinson's disease, and Huntington's disease.
2. Stroke: A stroke occurs when blood flow to the brain is interrupted, leading to cell death and potential long-term disability.
3. Traumatic brain injury: This type of injury occurs when the brain is subjected to a sudden and forceful impact, such as in a car accident or fall.
4. Infections: Bacterial, viral, and fungal infections can all cause CNS diseases, such as meningitis and encephalitis.
5. Autoimmune disorders: These are conditions in which the immune system mistakenly attacks healthy cells in the brain, leading to inflammation and damage. Examples include multiple sclerosis and lupus.
6. Brain tumors: Tumors can occur in any part of the brain and can be benign or malignant.
7. Cerebrovascular diseases: These are conditions that affect the blood vessels in the brain, such as aneurysms and arteriovenous malformations (AVMs).
8. Neurodevelopmental disorders: These are conditions that affect the development of the brain and nervous system, such as autism spectrum disorder and attention deficit hyperactivity disorder (ADHD).

CNS diseases can have a significant impact on quality of life, and some can be fatal. Treatment options vary depending on the specific diagnosis and severity of the disease. Some CNS diseases can be managed with medication, while others may require surgery or other interventions.

1. Preeclampsia: A condition characterized by high blood pressure during pregnancy, which can lead to complications such as stroke or premature birth.
2. Gestational diabetes: A type of diabetes that develops during pregnancy, which can cause complications for both the mother and the baby if left untreated.
3. Placenta previa: A condition in which the placenta is located low in the uterus, covering the cervix, which can cause bleeding and other complications.
4. Premature labor: Labor that occurs before 37 weeks of gestation, which can increase the risk of health problems for the baby.
5. Fetal distress: A condition in which the fetus is not getting enough oxygen, which can lead to serious health problems or even death.
6. Postpartum hemorrhage: Excessive bleeding after delivery, which can be life-threatening if left untreated.
7. Cesarean section (C-section) complications: Complications that may arise during a C-section, such as infection or bleeding.
8. Maternal infections: Infections that the mother may contract during pregnancy or childbirth, such as group B strep or urinary tract infections.
9. Preterm birth: Birth that occurs before 37 weeks of gestation, which can increase the risk of health problems for the baby.
10. Chromosomal abnormalities: Genetic disorders that may affect the baby's growth and development, such as Down syndrome or Turner syndrome.

It is important for pregnant women to receive regular prenatal care to monitor for any potential complications and ensure a healthy pregnancy outcome. In some cases, pregnancy complications may require medical interventions, such as hospitalization or surgery, to ensure the safety of both the mother and the baby.

The official diagnosis was organic brain damage, Alzheimer's disease. Initially, the writer settled into very good conditions ... Titarenko suffered from chronic alcoholism. Every year, his condition only worsened. Around 1989 Titarenko finally moved to the ...
Korsakoff psychosis typically follows after the symptoms of Wernicke's decrease and result from chronic brain damage. Korsakoff ... Neurotrauma, brain damage or brain injury (BI) is the destruction or degeneration of brain cells. Brain injuries occur due to a ... Look up brain damage in Wiktionary, the free dictionary. Brain damage at Curlie Brain injury at Curlie (CS1 German-language ... and cause of the brain damage (see Traumatic brain injury, Focal and diffuse brain injury, Primary and secondary brain injury ...
Murelius O, Haglund Y (1991). "Does Swedish amateur boxing lead to chronic brain damage? A retrospective neuropsychological ... "The effect of character and array type on visual spatial search acuity following traumatic brain injury". Brain Injury. 12: 69- ... and motor speed on visual spatial search quality following traumatic brain injury". Brain Injury. 11 (1): 59-66. doi:10.1080/ ... The speed of finger tapping has also been found to be related to severity of initial traumatic brain injury, and can be used to ...
I was pretty lucky that I didn't have brain damage." In a 2015 interview on the Philadelphia-based Preston & Steve radio show ... Summers went back to his initial doctor in a panic; ultimately the original diagnosis of chronic lymphatic leukemia was ... He created and hosted the short-lived children's game show Pick Your Brain, co-hosted Great Day America on the PAX Network, ... Exploratory surgery revealed that he had chronic lymphatic leukemia. The initial doctor recommended chemotherapy, but fearing ...
However, the brain is still susceptible to damage, disease, and infection. Damage can be caused by trauma, or a loss of blood ... Chronic traumatic encephalopathy can develop following multiple head injuries. Neurodegenerative diseases result in progressive ... Immediate problems may include bleeding within the brain, this may compress the brain tissue or damage its blood supply. ... Brain of human embryo at 4.5 weeks, showing interior of forebrain Brain interior at 5 weeks Brain viewed at midline at 3 months ...
A potential cause of chronic alcoholic cerebellar dysfunction is an alteration of GABA-A receptor. This dysfunction causes an ... "that can cause severe brain damage and dysfunction". Adolescents are much more vulnerable to alcohol-related brain damage in ... Alcohol-related brain damage alters both the structure and function of the brain as a result of the direct neurotoxic effects ... can lead to damage in the limbic system that occurs after a relatively short period of time. This brain damage increases the ...
... brain damage, and death. Haemophilic arthropathy is characterized by chronic proliferative synovitis and cartilage destruction ... Bleeding into a joint can result in permanent damage while bleeding in the brain can result in long term headaches, seizures, ... Rapid treatment of bleeding episodes decreases damage to the body. Factor VIII is used in haemophilia A and factor IX in ... Bleeding into soft tissues such as muscles and subcutaneous tissues is less severe but can lead to damage and requires ...
Brain and kidney damage can result. Chronic exposure can cause losses in bone density, weight loss and anorexia. Experiments ... Copper can also cause damage to the liver and other major organs. Metal fluorides are generally safe at low levels and are ...
Harmful chemicals damage the blood-brain barrier. Cerebral edema (swelling of the brain) occurs due to leakage of large ... Acquired Mitochondropathy-A New Paradigm in Western Medicine Explaining Chronic Diseases). The fact that the ischemic cascade ... This "vasogenic edema" causes compression of and damage to brain tissue (Freye 2011; ... If and when the brain is reperfused, a number of factors lead to reperfusion injury. An inflammatory response is mounted, and ...
It can have a variety of long-term adverse effects on health, such as liver damage and brain damage, and its consumption is the ... Chronic alcohol abusers are at additional risk for brain injury from related causes, such as poor nutrition, liver disease, and ... Alcohol can cause brain damage, Wernicke's encephalopathy and Alcoholic Korsakoff syndrome (AKS) which frequently occur ... Prolonged heavy consumption of alcohol can cause significant permanent damage to the brain and other organs resulting in ...
... his brain was donated to research in sports-related brain damage. His brain, unlike others, showed no evidence of chronic ... Sean Fitz-Gerald (26 July 2011). "Researchers find degenerative disease in brains donated by CFL players". National Post. ... Tony Care (26 July 2011). "Donated CFL brains show concussion-related disease". CBC News. Retrieved 2 January 2012. Tony ...
Olbrich R, Watzl H, Völter M, Siedow H (March 1991). "Lithium in the treatment of chronic alcoholic patients with brain damage ...
An eclamptic convulsion usually does not cause chronic brain damage unless intracranial haemorrhage occurs. If a pregnant woman ... Such disorders include seizure disorders as well as brain tumor, aneurysm of the brain, and medication- or drug-related ... Sanders, T G; Clayman, D A; Sanchez-Ramos, L; Vines, F S; Russo, L (August 1991). "Brain in eclampsia: MR imaging with clinical ... These may be signs that the brain is swelling (cerebral edema) or bleeding (intracerebral hemorrhage). Eclampsia, like pre- ...
"Fetal cerebrovascular response to chronic hypoxia--implications for the prevention of brain damage" (PDF). The Journal of ... During pregnancy, women with preeclampsia faces serious risk of damage to vital organs such as the kidneys, liver, brain, and ... Intrauterine hypoxia can cause cellular damage that occurs within the central nervous system (the brain and spinal cord). This ... leading to increased susceptibility to hypoxia-induced brain damage. Maternal anemia in which smoking has also been implicated ...
This delayed neurodegeneration could be associated with chronic brain damage that follows a stroke. Studies have found that ... These areas of the brain that had the most damage at these stages. The increase in quinolinic acid correlates with the early ... Brain ischemia is characterized by insufficient blood flow to the brain. Studies with ischaemic gerbils indicate that, after a ... Quinolinic acid has also been found in HAND patients' brains. In fact, the amount of quinolinic acid found in the brain of HAND ...
Chronic alcohol exposure can result in increased DNA damage in the brain, as well as reduced DNA repair and increased neuronal ... The developing adolescent brain is at increased risk of brain damage and other long-lasting alterations to the brain. ... This region of the brain is vulnerable to chronic alcohol-induced oxidative DNA damage. The social skills that are impaired by ... The brain goes through dynamic changes during adolescence as a result of advancing pubertal maturation, and alcohol can damage ...
Signs of chronic brain damage can also affect irritability, paranoia and cause violent outbursts. Dementia pugilistica is ... most of the contusive damage is found deeper in the brain. In sports, most cerebral contusions are caused when the brain is ... there is bruising to the brain and damage to the internal tissue and blood vessels. Additionally, the jarring of the brain ... The damage is done in four primary sites of the brain: the septal regions, the cerebellum, the substantia nigra and the neurons ...
The chronic phase of uncontrollable epilepsy leads to various degree of cognitive impairments. These seizures damage the ... Brain. Brain.oxfordjournals.org. 134 (Pt 10): 2802-2818. doi:10.1093/brain/awr215. PMID 21914716. Fox, Kristy; Wells, Mary ... The damage mainly occurred in frontal and temporal lobe regions and resulted in learning disorder, memory function impairment, ... Medical diagnostic tests may initially return no clear diagnosis and may not detect any obvious swelling on the brain. The ...
Relatives would later question if this caused Brian to have brain damage; as a youth Brian suffered severe headaches followed ... Brian was also a chronic bed wetter, a condition his adult father also suffered from. Brian showed classic symptoms of ... Taylor, Matthew (2011-11-14). "Psychopaths: Born Evil or with a Diseased Brain?". BBC News. Retrieved 2013-07-25. Gutowsk, ...
"Repeated Head Hits, Not Just Concussions, May Lead To A Type Of Chronic Brain Damage". NPR.org. Archived from the original on ... Repeated concussions (and possibly sub-concussive head impacts) can increase a person's risk in later life for CTE (chronic ... Bennet Omalu, a neuropathologist who was the first to discover and publish findings of chronic traumatic encephalopathy or CTE ... Age of First Exposure to Tackle Football and Chronic Traumatic Encephalopathy Archived December 15, 2018, at the Wayback ...
Alcoholism is a chronic problem. However, if managed properly, damage to the brain can be stopped and to some extent reversed. ... Brain. Oxford University Press. 130 (1): 36-47. doi:10.1093/brain/awl303. PMID 17178742. Morse, RM; Flavin, DK (August 26, 1992 ... Upon analyzing the brains of these two strains of rats, it was discovered that there were differences in chemical composition ... However, with recent advances in neuroscience, it is clear that dependence is as much a disorder of the brain as any other ...
Brain damage is typically seen with chronic long-term use of solvents as opposed to short-term exposure. Even though many ... Brain damage is typically seen with chronic long-term use as opposed to short-term exposure. Parkinsonism (see: Signs and ... and damage to the central nervous system and brain. Serious but potentially reversible effects include liver and kidney damage ... The hypoxic effect of inhalants can cause damage to many organ systems (particularly the brain, which has a very low tolerance ...
Methamphetamine use can be neurotoxic, which means it damages dopamine neurons. As a result of this brain damage, chronic use ... "Drugs, Brains, and Behavior: The Science of Addiction - Drug Misuse and Addiction". www.drugabuse.gov. North Bethesda, Maryland ... It contains nicotine, which crosses the blood-brain barrier in 10-20 seconds. It mimics the action of the neurotransmitter ... acetylcholine at nicotinic acetylcholine receptors in the brain and the neuromuscular junction. The neuronal forms of the ...
... has the propensity to result in brain damage faster as well as more severely than chronic drinking (alcoholism ... Frequent binge drinking can lead to brain damage faster and more severely than chronic drinking (alcoholism). The neurotoxic ... The tolerance that occurs during chronic ('non-stop') drinking delays alcohol-related brain damage compared to binge drinking, ... "Biochemical and neurotransmitter changes implicated in alcohol-induced brain damage in chronic or 'binge drinking' alcohol ...
"Biochemical and neurotransmitter changes implicated in alcohol-induced brain damage in chronic or 'binge drinking' alcohol ...
The reason that chronic sustained alcoholism is thought by some researchers to be less brain damaging than binge drinking is ... regular binge drinking in the long-term is thought to be more likely to result in brain damage than chronic (daily) alcoholism ... "Biochemical and neurotransmitter changes implicated in alcohol-induced brain damage in chronic or 'binge drinking' alcohol ... The finding of kindling in alcoholism is consistent with the mechanism of brain damage due to binge drinking and subsequent ...
Lead - can cause damage to the nervous connections as well as blood and brain disorders. Specific diseases include nephropathy ... ISBN 978-0-415-70040-5. Ngim, CH; Foo, SC; Boey, K.W.; Keyaratnam, J (1992). "Chronic neurobehavioral effects of elemental ... and evidence of damage to the lung tissue. Zinc - The U.S. Food and Drug Administration (FDA) has stated that zinc damages ... PCBs - People exposed to high levels of PCBs can exhibit skin conditions, such as rashes and liver damage. Common symptoms ...
Stress can cause acute and chronic changes in certain brain areas which can cause long-term damage. Over-secretion of stress ... Chronic stress can affect the brain structure and cognition. Studies considered the effects of both intrinsic and extrinsic ... A case of sociopathy". Brain. 123 (6): 1122-1141. doi:10.1093/brain/123.6.1122. PMID 10825352. Hitch, G. J. (1985). Short-term ... When chronic stress is perceived, however, the body is in a continuous state of fight-or-flight response and never reaches a ...
Brain damage is typically seen with chronic long-term use of solvents as opposed to short-term exposure. Even though contact ...
Knocking a person unconscious or even causing a concussion may cause permanent brain damage. There is no clear division between ... Also, contact sports, especially combat sports, are directly related to a brain disease called chronic traumatic encephalopathy ... Brain. 141 (2): 422-458. doi:10.1093/brain/awx350. PMC 5837414. PMID 29360998 - via Silverchair. Montenigro, Philip H; Baugh, ... No evidence of brain trauma or concussion was found and the initial autopsy has proved inconclusive. Coroner Rae Wooten ...
Repeated bleeds into a joint capsule can cause permanent joint damage and disfigurement resulting in chronic arthritis and ... Joints Muscles Digestive tract Brain Muscle and joint haemorrhages - or haemarthrosis - are indicative of haemophilia, while ... Joint damage is not a result of blood in the capsule but rather the healing process. When blood in the joint is broken down by ...
Hypoxic damage can also occur to most of the infant's organs (heart, lungs, liver, gut, kidneys), but brain damage is of most ... Causes for early birth may be unknown or may be related to certain chronic conditions such as diabetes, infections, and other ... newborn or oligohydramnios Fetal demise Gestational hypertension Maternal conditions such as gestational diabetes or chronic ...
This substance use may be episodic binge drinking or chronic substance use that can meet diagnostic criteria for substance use ... BTT incorporates both attachment and damage from a caregiver in the definition of the theory. BTT includes dissociation as a ... Schore, Allan N. (2002-02-01). "Dysregulation of the right brain: a fundamental mechanism of traumatic attachment and the ... dissociation during times of extreme stress or trauma can invoke neural mechanisms resulting in long-term alterations in brain ...
... is known to cause depression symptoms but the effect of chronic stress on sleep can lead to a ripple effect of further damage ... "Brain Basics: Understanding Sleep". Office of Communications and Public Liaison, National Institute of Neurological Disorders ... In a study focusing on the impacts of chronic stress on the heart, it was found that during times of chronic stress, the body ... Chronic stress leads to the malfunction of the HPA axis which can lead to sudden relapse in previously well-recovering ...
... brains. The Bumblebee Conservation Trust considers this evidence of reduced brain function "particularly alarming given that ... Evidence from Japan and South America indicates bumblebees can escape and naturalise in new environments, causing damage to ... Stanley, Dara A.; Raine, Nigel E. (2017). "Bumblebee colony development following chronic exposure to field-realistic levels of ... "Bumblebee brains affected by neonicotinoids". Bumblebee Conservation Trust. 3 February 2014. Archived from the original on 19 ...
Furthermore, damage of arterioles and capillaries was found in brain tissue samples of people who died from COVID‑19. COVID‑19 ... The virus can cause acute myocardial injury and chronic damage to the cardiovascular system. An acute cardiac injury was found ... Research conducted when Alpha was the dominant variant has suggested COVID-19 may cause brain damage. It is unknown if such ... shedding of olfactory epithelium Brain: infarction Kidneys: acute tubular damage. Spleen: white pulp depletion. Preventive ...
At the time, his daughter suffered from a chronic illness, which required continuous medical attention. Soon after this ... using chemicals like ammonia to enhance absorption of nicotine in the lungs and affect the brain and central nervous system ... 368 billion settlement in health-related damages by the tobacco companies. Thousands of pages of B&W documents were donated ...
Seddon HJ (1943). "Three Types of Nerve Injury". Brain. 66 (4): 238-288. doi:10.1093/brain/66.4.237. Savastano (2014). "Sciatic ... Classification of nerve damage was well-defined by Sir Herbert Seddon and Sunderland in a system that remains in use. The ... "A systematic review of therapeutic facet joint interventions in chronic spinal pain". Pain Physician. 10 (1): 229-53. doi: ... doi:10.1093/brain/74.4.491. PMID 14895767. Burnett (2004). "Pathophysiology of peripheral nerve injury: a brief review". ...
... overdose has also been described to cause spinal cord infarction in high doses and ischemic damage to the brain, due ... It is unclear if use in chronic pain results in improved quality of life or ongoing pain relief. Oxycodone is available as a ... and brain. At equilibrium the unbound concentration in the brain is threefold higher than the unbound concentration in blood ... Oxycodone is used for managing moderate to severe acute or chronic pain when other treatments are not sufficient. It may ...
... which is a category of kidney damage that may cause chronic kidney disease. Dogs may also experience chronic joint disease if ... A report on three patients and review of literature". Brain. 119 (Pt 6): 2143-54. doi:10.1093/brain/119.6.2143. PMID 9010017. ... Chronic symptoms from an autoimmune reaction could explain why some symptoms persist even after the spirochetes have been ... The term "chronic Lyme disease" is controversial and not recognized in the medical literature, and most medical authorities ...
"Heart-type fatty acid-binding protein is more sensitive than troponin T to detect the ongoing myocardial damage in chronic ... Cheon MS, Kim SH, Fountoulakis M, Lubec G (2004). Heart type fatty acid binding protein (H-FABP) is decreased in brains of ... H-FABP is more effective than Troponin T in risk stratifying Chronic Heart Failure patients. H-FABP is beginning to create ...
... at a dose of 25 mg/day for 3 weeks has been found to decrease cortisol levels by 16% in adults with chronic insomnia ... Cusack B, Nelson A, Richelson E (May 1994). "Binding of antidepressants to human brain receptors: focus on newer generation ... liver damage of the cholestatic type (rarely), hepatitis (extremely rare), leuko- or thrombocytopenia (rarely), agranulocytosis ... for the treatment of chronic urticaria (hives). As of 2017, it is in phase II clinical trials for this indication. The drug was ...
Brain Research. Molecular Brain Research. 109 (1-2): 18-33. doi:10.1016/S0169-328X(02)00458-8. PMID 12531512. MRC (Medical ... The same drug has been shown to interfere in the hypothalamic-pituitary-adrenal axis, with chronic oral administration of this ... has been found to cause more damage to neurons in the presence of group I mGluR agonists. On the other hand, agonists of group ... Brain Research Reviews. 31 (2-3): 302-12. doi:10.1016/S0165-0173(99)00046-6. PMID 10719157. S2CID 13040014. Patil ST, Zhang L, ...
The similar brain functions and behaviors of dogs with CCD and humans with OCD suggests they have a connection, not only in ... Rhesus macaque males become hyperactive in response to long-term chronic food restriction. Thin sow syndrome (TSS) is a ... bodily damage, or wasted effort." Being apathetic can have a fitness advantage for the organism. Depression has also been ... Rats have also been used to test the possibility of a problem with dopamine levels in the brains of animals that exhibit ...
The pathology is damage to the core of the brain including the thalamus and mamillary bodies. Its most striking clinical ... Chronic psychoses can supervene many years later, based on myxoedema, hypoglycaemia or Addisonian crisis. But these patients ... The cause of postpartum bipolar disorder breaks down into two parts - the nature of the brain anomalies that predispose to ... In fatal cases, there are arterial lesions in many organs including the brain. This is the second most frequent organic ...
Pot doesn't cause permanent brain damage. Reuters Health E-Line Bolla KI, Brown K, Eldreth D, Tate K, Cadet JL (November 2002 ... Falvo, D R (2005). Medical and psychosocial aspects of chronic illness and disability (Third ed.). Jones & Bartlett Learning. p ... DeLisi LE (March 2008). "The effect of cannabis on the brain: can it cause brain anomalies that lead to increased risk for ... but did not cause permanent brain damage. Researchers looked at data from 15 previously published controlled studies involving ...
... chronic pain and Parkinson's disease. In 2012, MTMC opened the area's first Epilepsy Monitoring Unit. The Saint Thomas Brain & ... an advanced stereostatic radiotherapy treatment that focuses radiation to the shape of the tumor and results in minimum damage ... Among the ailments and diseases treated through the Neurosciences Institute are epilepsy, stroke, brain tumors, ALS, sleep ... focusing on chronic pain and incontinence. The center touts the use of unique treatments, such as non-surgical interventions ( ...
Pieces of fat can wind up in the lungs, or even the brain. Fat emboli may cause permanent disability or, in some cases, be ... Some side effects and complications include, but are not limited to, the following: Pain, which may be temporary or chronic ... Ultrasound-assisted liposuction techniques used in the 1980s and 1990s were associated with cases of tissue damage, usually ... Reconstructive uses include treatment of lipedema, to remove excess fat in the chronic medical condition lymphedema, and to ...
BRD can lead to lung tissue damage and impair the performance of the cattle leading to a low final body mass at slaughter, or ... Since only a tiny amount of the contaminating prion begins the cascading brain disease, any amount of mixed feed could cause ... evolutionary implications for reducing diet-related chronic disease". European Journal of Clinical Nutrition. 56 (3): 181-91. ... composition of wild ruminant tissues may serve as a model for dietary lipid recommendations in treating and preventing chronic ...
... because they pass through the brain stem on one side of its central core. Prolonged pain, on the other hand, such as chronic ... Melzack and Wall noticed that some individuals felt immense pain when damage to the body was minimal, and some people with ... Melzack R (Dec 2001). "Pain and the Neuromatrix in the Brain". J Dent Educ. 65 (12): 1378-82. doi:10.1002/j.0022-0337.2001. ... in which he asserted that pain is subjective and multidimensional because several parts of the brain contribute to it at the ...
However, dysregulation of ROS can lead to DNA damaging, inactivation of enzymes and proteins, disruption of membranes. This ... Therefore, they have the ability to prevent chronic diseases such as cancer, cerebrovascular and cardiovascular diseases and ... brain, kidney and skin against oxidative stress. This is done by reducing the concentration of ROS and by enhancing the ... from Blakeslea trispora may lead to great improvements to human health in the treatment and prevention of certain chronic ...
... resulting in some fiber damage. Edema and fiber damage were not noted in another cohort of animals studied 9 days after landing ... studies performed on rodents during chronic HS indicate that only a transient reduction occurs in electrical activity of the ... Experimental Brain Research. Experimentelle Hirnforschung. Experimentation Cerebrale. 113 (1): 104-16. doi:10.1007/bf02454146. ... Their findings suggest that in atrophied slow types of skeletal muscle, there is no evidence of fiber damage when the muscles ...
... meaning nerves beyond the brain and spinal cord. Damage to peripheral nerves may impair sensation, movement, gland, or organ ... Cooper TE, Fisher E, Gray AL, Krane E, Sethna N, van Tilburg MA, Zernikow B, Wiffen PJ (July 2017). "Opioids for chronic non- ... Wiffen PJ, Derry S, Bell RF, Rice AS, Tölle TR, Phillips T, Moore RA (June 2017). "Gabapentin for chronic neuropathic pain in ... Cooper TE, Chen J, Wiffen PJ, Derry S, Carr DB, Aldington D, Cole P, Moore RA (May 2017). "Morphine for chronic neuropathic ...
On the other hand, a patient with a chronic hepatic disease can suffer an acute decompensation of liver function following a ... Bergeron, M; Swain, MS; Reader, TA; Grondin, L; Butterworth, RF (July 1990). "Effect of ammonia on brain serotonin metabolism ... Graft damage during preparation and transportation Infection Hepatotoxic drugs Graft rejection Technical complications ( ... Hessel, FP (Oct 5, 2006). "Economic evaluation of the artificial liver support system MARS in patients with acute-on-chronic ...
On September 5, 2018, a federal lawsuit was filed to seek monetary damages on the basis of the inflicted psychological harm and ... "Decades of psychological and brain research have demonstrated that forced parental separation and placement in incarceration- ... separation and reported that the separation of the children from their parents together with a background of chronic and acute ... and money for damages of pain and suffering. Another lawsuit is that of a 9-year-old boy from Honduras who, according to the ...
Accumulation of DNA damage with age in the mammalian brain has been reported during the period 1971 to 2008 in at least 29 ... "The emerging role of epigenetic modifiers in repair of DNA damage associated with chronic inflammatory diseases". Mutation ... showed that DNA damages which block the polymerase chain reaction in rat brain accumulate with age. Swain and Rao observed ... In the brain, promoters of genes with reduced expression have markedly increased DNA damage. In cultured human neurons, these ...
Progress in Brain Research. Vol. 182. Elsevier. pp. 343-73. doi:10.1016/s0079-6123(10)82015-1. ISBN 978-0-444-53616-7. PMC ... Overall toxicity was low, with no high-grade haematological (blood) or kidney damage reported. At the end of that same year, a ... Kattah AG, Garovic VD (May 2013). "The management of hypertension in pregnancy". Advances in Chronic Kidney Disease. 20 (3): ... Furthermore, the intravenous contrast used in CT can cause kidney damage and should therefore be avoided in patients with pre- ...
However, evolution has provided all extant plants and animals with defenses that repair such damage or remove the damaged cells ... The study confirmed the results of the 2012 UK study for leukaemia and brain cancer but also investigated other cancer types. ... I. Survival and tumor incidence following chronic irradiation of 0.11 r per day". Journal of the National Cancer Institute. 15 ... Neurological damage has a different biology than cancer. In a 2009 study, cancer rates among UK radiation workers were found to ...
However, some may have high eye pressure for years and never develop damage. Conversely, optic nerve damage may occur with ... also known as chronic open-angle glaucoma, chronic simple glaucoma, glaucoma simplex High-tension glaucoma Low-tension glaucoma ... that carries visual information from the eye to the brain, thereby causing changes in vision. Jindal A, Ctori I, Virgili G, ... The modern goals of glaucoma management are to avoid glaucomatous damage and nerve damage, and preserve visual field and total ...
Is chronic brain damage in boxing a hazard of the past? M Kaste, T Kuurne, J Vilkki, K Katevuo, K Sainio, H Meurala ... Is chronic brain damage in boxing a hazard of the past? M Kaste et al. Lancet. 1982. . ... Brain damage in modern boxers. Casson IR, Siegel O, Sham R, Campbell EA, Tarlau M, DiDomenico A. Casson IR, et al. JAMA. 1984 ... The results indicate that modern medical control of boxing cannot prevent chronic brain injuries but may create a dangerous ...
Chronic brain damage in HIV-infected individuals under antiretroviral therapy is associated with viral reservoirs, sulfatide ... Chronic brain damage in HIV-infected individuals under antiretroviral therapy is associate ... HIV infection has become a chronic and manageable disease due to the effective use of antiretroviral therapies (ART); however, ... Here, we identified that glial and myeloid viral reservoirs are associated with local myelin damage and the release of several ...
Prenatal and perinatal factors associated with brain disorders / John M. Freeman, editor. by Freeman, John M , National ...
Brain damage, chronic: 32 Brain diseases: 50 Cannabis: 121 Child abuse: 26 Child behavior: 115, 135, 136, 167, 182 Child ...
Kidney and brain damage. *Death. Health effects from chronic exposures A person who is exposed to lead over long periods of ... Lead can damage a developing babys nervous system. It can also cause miscarriage, stillbirths, and infertility in both men and ... Some scientists think exposures to lead AND noise together can damage hearing to an even greater degree than hearing loss ...
... collection of blood and blood breakdown products between the surface of the brain and its outermost covering (the dura). The ... Permanent brain damage. *Persistent symptoms, such as anxiety, confusion, difficulty paying attention, dizziness, headache, and ... A chronic subdural hematoma is an "old" collection of blood and blood breakdown products between the surface of the brain and ... A collection of blood then forms over the surface of the brain. In a chronic subdural collection, blood leaks from the veins ...
Kernicterus causes brain damage that leads to specific symptoms.. Kernicterus is an irreversible and chronic condition when ... Kernicterus is a type of brain damage caused by high levels of bilirubin in a babys blood. Jaundice begins with yellowing of ...
Chronic brain damage in HIV-infected individuals under antiretroviral therapy is associated with viral reservoirs, sulfatide ...
Chronic Disease [C23.550.291.500] * Brain Damage, Chronic [C23.550.291.500.063] * Brain Injury, Chronic [C23.550.291.500. ... Brain Damage, Chronic Preferred Concept UI. M0002872. Scope Note. A condition characterized by long-standing brain dysfunction ... see BRAIN DISEASES, METABOLIC); and other conditions.. Terms. Brain Damage, Chronic Preferred Term Term UI T005484. Date01/01/ ... see BRAIN DISEASES, METABOLIC); and other conditions.. Entry Term(s). Chronic Encephalopathy Encephalopathy, Chronic Date ...
stroke-brain damage caused by lack of blood flow to the brain ... Chronic Kidney Disease (CKD) Show child pages. * What Is ... More information about nutrition for CKD is provided in the NIDDK health topics, Eating Right for Chronic Kidney Disease and ... chronic kidney disease (CKD)-reduced kidney function over a period of time ... such as improving the quality of life for people with chronic illnesses. Find out if clinical trials are right for you. ...
Sometimes brain damage is irreversible. As many as 50%. of stroke survivors experience chronic disability post-stroke. ... It is a medical emergency that occurs when the brain receives inadequate blood flow and cells become damaged or die. ... It is an important time for the brain to restructure its functions, adjusting to the damage from the stroke. ... A 2021 study found that the brain is actively reorienting its functions during the subacute phase. Between 60-90 days, it is ...
Categories: Brain Damage, Chronic Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
"These results give us a way to test new therapies that might speed up the brains healing process and prevent brain damage that ... Chronic lesions with inflamed rims, or "smoldering" plaques, in the brains of people with multiple sclerosis (MS) have been ... Reich and his team reported that damaging, chronic active lesions may be a hallmark of progressive MS. The current study ... A subset of people develop progressive MS, resulting in extensive brain tissue damage and disability. Anti-inflammatory ...
Brain Damage, Chronic / etiology Actions. * Search in PubMed * Search in MeSH * Add to Search ... Assessment of brain connectome alterations in male chronic smokers using structural and generalized q-sampling MRI. Weng JC, ... These data suggest chronic tobacco use is correlated with prefrontal gray matter damage , while differences in insula gray ... Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced ...
Brain Damage, Chronic/congenital; Brain Damage, Chronic/etiology*; Brain Damage, Chronic/metabolism; Brain Damage, Chronic/ ... Because the developing brain requires iron during specific phases of growth in a region-specific manner, we hypothesized that ... Title: Gestational iron deficiency differentially alters the structure and function of white and gray matter brain regions of ...
Moderate exposure can cause residual damage and a serious exposure that causes coma or convulsions may damage the brain and ... and chronic cough. Neurologic symptoms, including psychological disorders, have been associated with chronic exposure. Chronic ... Survivors of severe exposure may develop psychological disturbances and permanent damage to the brain and heart. The cornea may ... Chronic Exposure. Hydrogen sulfide does not accumulate in the body. Nevertheless, repeated or prolonged exposure has been ...
... perhaps we can also learn from our colleagues involved in assessing the brain damage that chronic alcohol exposure produces in ... This might explain why facial dysmorphology is linked to a pattern of brain damage. The face may be a marker for brain damage, ... West stressed that lack of recovery indicates brain damage, but Dr. Lozoff was reluctant to use the term "brain damage." ... Lozoff would consider brain damage to include subtle brain changes related to nerve conduction measures. Dr. Lozoff replied ...
Organ damage is the major medical consequence of chronic alcohol abuse. This damage is mostly to the liver, brain, ... Research is needed into the underlying mechanisms of alcoholic hepatitis, brain damage (especially alcohol dementia/Korsakoffs ... Understanding the cellular and molecular mechanisms of craving for alcohol after chronic use and how it might be reduced is ... Since death from alcohol overdoses results from respiratory arrest, those depressed mechanisms in the brain stem related to ...
Chronic hypertension related to HUS. Prognosis:. • Permanent brain damage (no hope to regain significant cognitive function). ... Severe neurologic damage (severe encephalopathy, brain damage, seizures, multiple episodes of brain hemorrhage, loss of ... Chronic kidney stage 3, with hypertension and proteinuria; damage from HUS, will likely require greater than one kidney ... Chronic kidney stage 3, damage from HUS, likely transplant candidate if survives ,10 years. • Requires 24-hour, 100% assistance ...
Thus, applications of neural probes are not limited to extracellular recording, brain-machine interface, and deep brain ... and investigation of brain disorders. However, the biggest limitation of the current neural probe technology is chronic ... While chronic viability is imperative for both clinical uses and animal experiments, achieving one is a major technological ... Thus, this review aims to outline the factors that potentially affect chronic recording in chronological order of implantation ...
8. Pharmacological strategies against glucocorticoid-mediated brain damage during chronic disorders.. Martocchia A; Curto M; ... Effect of chronic stress on tumorigenesis and development.. Wang C; Shen Y; Ni J; Hu W; Yang Y. Cell Mol Life Sci; 2022 Aug; 79 ... Brain Behav Immun; 2013 Mar; 30 Suppl():S41-7. PubMed ID: 22790082. [TBL] ... Brain Behav Immun; 2007 Nov; 21(8):1009-18. PubMed ID: 17889502. [TBL] ...
Infants affected by the disease face possible paralysis or damage to the brain and other organs. ... Neurofibromatosis can leave its patients miserable and debilitated with chronic itching or pain from disfiguring tumors. ... Tags: Allergy, Asthma, B Cell, Blood, Blood Vessel, Blood Vessels, Brain, Cell, Cell Division, Chemicals, Chemotherapy, ... The tumors can interfere with the function of the brain and other organs, or prevent patients from walking. ...
Those With Chronic Pain More Likely to Have Suicidal Thoughts Mind. What Happens if the Prefrontal Cortex Is Damaged? ... To investigate a possible brain basis of the EHS, the patients had resting state fMRI scanning. Heuser and Heuser say that all ... A strange new paper reports abnormal brain activity in 10 patients with electrohypersensitivity (EHS) - a controversial ... The Electrosensitive Brain. NeuroskepticBy NeuroskepticJul 7, 2017 1:03 PM ...
Lupus is a chronic (long-lasting) disease that damages different organs, including the skin, joints, kidneys, heart, and brain ... Lupus is a chronic disease, but treatments can help with symptoms and lower the risk of flares. New and better tools to ... The damage happens because the germ-fighting immune system attacks the bodys own cells. This is called autoimmunity. ...
Traumatic brain injury (TBI): Chronic headaches can also result from TBI when an impact damages the brain. ... Brain tumor: About 50% of people with cancerous tumors in the brain experience headaches, which can become chronic and ... Inflammation: Inflammation or interrupted blood flow around the brain can also cause chronic headaches. ... Sudden onset of chronic headache in those 50 or older. *New headaches in those with a history of cancer or human ...
... brain damage or spasticity.. Pulmonary: Debilitated patients with chronic lung disease; reduction in bronchial secretions can ...
Chronic arthritis. *Brain and nerve damage. *Hemolytic uremic syndrome, resulting in kidney failure ...
  • Ethylmalonic encephalopathy (EE) causes damage to the brain, nerves, and blood vessels. (nih.gov)
  • The condition, known as chronic traumatic encephalopathy, or CTE, was the first hard evidence that playing football could cause permanent brain damage. (pbs.org)
  • These studies show that prion protein, like the tau protein in chronic traumatic encephalopathy (CTE), acts abnormally following brain injury. (nih.gov)
  • Permanent or transitory encephalopathy arising from severely reduced oxygen delivery to the brain. (wikipedia.org)
  • A form of encephalopathy caused by chemicals and prescription drugs, often resulting in permanent brain damage. (wikipedia.org)
  • Prenatal and perinatal factors associated with brain disorders / John M. Freeman, editor. (who.int)
  • Using brain tissue from humans, researchers at the National Institutes of Health's National Institute of Neurological Disorders and Stroke (NINDS) built a detailed cellular map of chronic MS lesions, identifying genes that play a critical role in lesion repair and revealing potential new therapeutic targets for progressive MS. The study was published in Nature . (nih.gov)
  • Thus, applications of neural probes are not limited to extracellular recording, brain-machine interface, and deep brain stimulation, but also include a wide range of new applications such as brain mapping, restoration of neuronal functions, and investigation of brain disorders. (mdpi.com)
  • 8. Pharmacological strategies against glucocorticoid-mediated brain damage during chronic disorders. (nih.gov)
  • It causes a group of brain disorders that share many clinical features. (psp.org)
  • We identified a set of cells that appear to be driving some of the chronic inflammation seen in progressive MS," said Daniel Reich, M.D., Ph.D., senior investigator at NINDS. (nih.gov)
  • Additionally, in another group of animals, blocking C1q reduced iron-containing microglia, revealing a potential new therapeutic avenue to treat chronic brain inflammation in MS and related neurodegenerative diseases. (nih.gov)
  • A 2022 review explains that, immediately after a stroke, the brain initiates a body-wide state of immune activation and inflammation. (medicalnewstoday.com)
  • Health claims of oral dietary supplements containing trans -resveratrol include protection from free-radical damage, inhibition of arthritic inflammation, inhibition of the cyclooxygenase-2 enzyme, protection of blood vessels, protection against cardiovascular disease and cancer, and alleviation of menopausal symptoms. (nih.gov)
  • This damage can also result in inflammation. (webmd.com)
  • A study funded by the National Institutes of Health found that biomarkers present in the blood on the day of a traumatic brain injury (TBI) can accurately predict a patient’s risk of death or severe disability six months later. (nih.gov)
  • Reports in the press of concussions in high-profile professional athletes have renewed a focus on diagnosis and management of mild traumatic brain injury. (jucm.com)
  • Dr Elliott selected 10 patients who had sustained traumatic brain injury. (psychiatrictimes.com)
  • While some stroke damage is irreversible, many people can regain skills through subacute phase rehabilitation. (medicalnewstoday.com)
  • According to scientists speaking at the conference session, this type of social isolation and sensory deprivation can have traumatic effects on the brain, many of which may be irreversible. (madinamerica.com)
  • This applies especially to the brain, its damage is usually irreversible. (refresher.com)
  • With repeated concussions, irreversible brain damage can occur over time , as we have already seen in history with a number of professional fighters (as well as other athletes). (refresher.com)
  • It also predisposes affected kids to irreversible brain damage or intellectual impairment that hinders their chances of becoming effective future drivers of economic growth. (businessdailyafrica.com)
  • Human spinal cord cell atlas provides foundation to study neurodegeneration, chronic pain, and other diseases. (nih.gov)
  • Microglia normally help protect the brain, but in MS and other neurodegenerative diseases, they can become overactive and secrete toxic molecules that damage nerve cells. (nih.gov)
  • Scientists at NIAID's Rocky Mountain Laboratories (RML) in Hamilton, Montana, have studied prion diseases since the 1960s when Dr. William Hadlow spearheaded work on the sheep brain disease known as scrapie, which was later shown to be a prion disease. (nih.gov)
  • These studies could provide a new model for scientists to study how prion diseases affect the human brain. (nih.gov)
  • My interest in pediatric rheumatology first sparked during my pediatric and adolescent medicine residency at the American University of Beirut, in Lebanon when I saw many patients devastated by their chronic disabling diseases, in the absence of a pediatric rheumatologist in the country. (lupus.org)
  • There is a spectrum of brain diseases that often onset in the 50's and 60's when people may have family responsibilities, careers and active lives. (psp.org)
  • A collection of diseases all caused by prions, and characterized by "spongy" brain tissue (riddled with holes), impaired locomotion or coordination, and a 100% mortality rate. (wikipedia.org)
  • In MS, the immune system attacks myelin, a protective layer that forms around nerve cells in the brain and spinal cord, leading to vision loss, muscle weakness, problems with balance and coordination, fatigue, numbness, and other debilitating symptoms. (nih.gov)
  • Occasionally, tumors may develop in the brain, on cranial nerves, or on the spinal cord. (news-medical.net)
  • Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. (psp.org)
  • The damage to the nerves in turn causes the brain to have trouble communicating with the rest of the body. (gofundme.com)
  • Chronic lesions with inflamed rims, or “smoldering” plaques, in the brains of people with multiple sclerosis (MS) have been linked to more aggressive and disabling forms of the disease. (nih.gov)
  • Researchers used single-cell RNA sequencing to map the cells found at the edges of chronic MS lesions. (nih.gov)
  • Chronic active lesions are characterized by a slow, expanding rim of immune cells called microglia. (nih.gov)
  • Other cells found at the edge of the lesions, such as astrocytes and lymphocytes, may also contribute to ongoing tissue damage. (nih.gov)
  • To better understand MS lesions, Dr. Reich and his colleagues used single-cell RNA sequencing, a powerful technique which enables researchers to catalog gene activity patterns in individual cells, to examine post-mortem brain tissue of five MS patients and three healthy controls. (nih.gov)
  • By analyzing the gene activity profiles of over 66,000 cells from human brain tissue, researchers created the first comprehensive map of cell types involved in chronic lesions, as well as their gene expression patterns and interactions. (nih.gov)
  • Dr. Reich's team found a great diversity of cell types in the tissue surrounding chronic active lesions compared to normal tissue, and a high proportion of immune cells and astrocytes at the active edges of those lesions. (nih.gov)
  • He had to end his career in 2013, at the age of 37, after lesions on his brain were discovered during a pre-match examination. (refresher.com)
  • CWD is caused by abnormal proteins or prions, which cause brain damage and eventual death among infected cervids (deer, elk, moose, caribou). (nih.gov)
  • These studies have shown how prions move through the brain and how cells in the brain called microglia help slow down disease. (nih.gov)
  • They have also shown that prions derived from slightly different forms of the prion protein gene can influence how prions accumulate in the brain. (nih.gov)
  • RML chronic wasting disease studies have focused on whether infectious prions can cross species from cervids, like deer and elk, into people. (nih.gov)
  • A 2021 study found that the brain is actively reorienting its functions during the subacute phase. (medicalnewstoday.com)
  • A subdural hematoma is more common in older adults because of normal brain shrinkage that occurs with aging. (medlineplus.gov)
  • These results give us a way to test new therapies that might speed up the brain's healing process and prevent brain damage that occurs over time. (nih.gov)
  • It is a medical emergency that occurs when the brain receives inadequate blood flow and cells become damaged or die. (medicalnewstoday.com)
  • This happens because DNA damage occurs along with protein oxidation. (webmd.com)
  • They often require surgery, especially when there are neurologic problems, seizures, or chronic headaches. (medlineplus.gov)
  • A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. (nih.gov)
  • A catch-all for brain dysfunction caused by infection, organ failure, or intoxication. (wikipedia.org)
  • A strange new paper reports 'abnormal' brain activity in 10 patients with electrohypersensitivity ( EHS ) - a controversial condition allegedly triggered by electromagnetic fields from devices such as phones and power-lines. (discovermagazine.com)
  • Heuser and Heuser say that 'all ten patients had abnormal functional MRI brain scans', but I'm not convinced. (discovermagazine.com)
  • To determine the function of C1q, researchers knocked out the gene in the microglia of mouse models of MS and examined the brain tissue for signs of neuroinflammation. (nih.gov)
  • A subset of people develop progressive MS, resulting in extensive brain tissue damage and disability. (nih.gov)
  • No objective evidence of specific pathology of brain tissue has been documented. (druglibrary.org)
  • Their organization, structure, and electrical signaling mimic some aspects of brain tissue. (nih.gov)
  • It can break down cell tissue and cause DNA damage. (webmd.com)
  • A study from the National Institutes of Health describes the immune response triggered by COVID-19 infection that damages the brain’s blood vessels and may lead to short- and long-term neurological symptoms. (nih.gov)
  • Eighteen former and active boxers underwent neurological examination, EEG, computed tomographic scan of the brain, and neuropsychological testing. (nih.gov)
  • Acetaldehyde insidiously interferes with brain functions, causing damage to neurological structures. (lesliekenton.com)
  • Multiple Sclerosis (MS) is a chronic and progressive auto-immune disease that affects the central nervous system. (gofundme.com)
  • Can affect many body systems, particularly the brain and nervous system. (wikipedia.org)
  • Cerebral organoids are small balls of human brain cells - developed from skin stem cells - that range in size from a poppy seed to a small pea. (nih.gov)
  • When you have fewer antioxidants, you're more likely to have cerebral damage if you had a stroke. (webmd.com)
  • To determine the long-term chronic effects of heavy marihuana use, the Commission has carefully reviewed the world literature and contemporary studies of heavy, chronic (up to 41 years) cannabis users in the world. (druglibrary.org)
  • Researchers have found differences in the gut microbiomes of people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) compared to healthy controls. (nih.gov)
  • This case describes a man with Down syndrome who, after an accident, sustained minor brain trauma. (psychiatrictimes.com)
  • This is a case of a man with Down syndrome whose recent brain injury likely caused him to regress to a rage state he had experienced when he was younger. (psychiatrictimes.com)
  • They also suggest that damage to the brain might be a way in which CJD infection starts in some people. (nih.gov)
  • The Department of Veterans Affairs (VA) and National Institutes of Health have launched a study to gain a better understanding of the chronic symptoms of Gulf War Illness. (nih.gov)
  • The goal of treatment is to control symptoms and reduce or prevent permanent damage to the brain. (medlineplus.gov)
  • Chronic subdural hematomas that cause symptoms usually do not heal on their own over time. (medlineplus.gov)
  • Contact your provider right away if you or a family member has symptoms of chronic subdural hematoma. (medlineplus.gov)
  • Diagnosis is based on the symptoms, clinical exam, laboratory testing of blood and urine, and imaging studies of the brain. (nih.gov)
  • Brain Damage In MMA And Boxing: What Do The Symptoms Look Like And How Can You Protect Yourself? (refresher.com)
  • Early researchers considered propranolol the best -blocker for rage symptoms-it was believed to affect norepinephrine activity in the brain because of its fat solubility. (psychiatrictimes.com)
  • When the alcohol produced by Candida begins to break down in your body, this produces acetaldehyde-a chemical six times more toxic to the brain than ethanol itself. (lesliekenton.com)
  • The NIH Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN​) Initiative Cell Census Network (BICCN) has unveiled an atlas of cell types and an anatomical neuronal wiring diagram for the mammalian primary motor cortex, derived from detailed studies of mice, monkeys, and humans. (nih.gov)
  • Brain damage is a frequent result of a career in professional boxing. (nih.gov)
  • Is chronic brain damage in boxing a hazard of the past? (nih.gov)
  • Boxing and chronic brain damage. (nih.gov)
  • The therapeutic use of propranolol to control rage behavior after brain trauma was well described in 1977 by Frank Elliott, MD, 1 former Chief of the department of neurology of the University of Pennsylvania. (psychiatrictimes.com)
  • To clarify these findings, we treated adult male Wistar Han rats with 0, 2, 10, or 25 mg/kg MPH by gavage once daily for 28 consecutive days and measured micronucleated reticulocyte (MN-RET) frequencies in blood, and DNA damage in blood, brain, and liver cells 4 hr after final dosing. (nih.gov)
  • Chronic use can cause brain and liver damage. (aroundthebay.ca)
  • Samples were provided by the Netherlands Brain Bank, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands, and the NINDS Neuroimmunology Clinic . (nih.gov)
  • Such decrements in normal pulmonary capacity may represent early warning signals in the development of chronic lung disease. (druglibrary.org)
  • The researchers theorized that nadolol muted the effects of excess adrenaline, thereby reducing the adrenergic "crisis signals" being sent by the body to the brain. (psychiatrictimes.com)
  • In a small study, researchers funded by the National Institutes of Health captured more than 1,000 hours of brain recordings from patients with OCD in the clinic and at home. (nih.gov)
  • Neurofibromatosis can leave its patients miserable and debilitated with chronic itching or pain from disfiguring tumors. (news-medical.net)
  • The tumors can interfere with the function of the brain and other organs, or prevent patients from walking. (news-medical.net)
  • All 10 patients had normal brain function before the injury but began demonstrating episodes of rage reactivity after the injury. (psychiatrictimes.com)
  • Stroke may happen in the brain, but it can pose health risks throughout the body for weeks or months. (medicalnewstoday.com)
  • Infants affected by the disease face possible paralysis or damage to the brain and other organs. (news-medical.net)
  • Inside Mike Webster's brain, he'd make a startling discovery: a disease never previously identified in football players. (pbs.org)
  • The North Carolina Wildlife Resources Commission recently announced that Chronic Wasting Disease (CWD) was detected in a sample from a white-tailed deer harvested in Yadkin County, which is just west of Winston-Salem. (nih.gov)
  • In response, an effort is underway to pass the Chronic Wasting Disease Research and Management Act, which would provide the USDA with $70 million per year in CWD research funding. (nih.gov)
  • Frontotemporal dementia (FTD) is a disease process that results in progressive damage to the temporal and/or frontal lobes of the brain. (psp.org)
  • ἐνκέφαλος "brain" + πάθος "suffering") means any disorder or disease of the brain , especially chronic degenerative conditions. (wikipedia.org)
  • however, several chronic aging -related comorbidities, including cognitive impairment , remain a major public health issue. (bvsalud.org)
  • Using a mouse model, researchers have discovered a new daily rhythm in a type of synapse that dampens brain activity. (nih.gov)
  • Researchers have identified two types of cells in our brains that are involved in organizing discrete memories based on when they occurred. (nih.gov)
  • Researchers may have mapped out new treatment pathways for chronic COVID-19. (medicaldaily.com)
  • Gestational iron deficiency differentially alters the structure and function of white and gray matter brain regions of developing rats. (nih.gov)
  • In turn, they can help protect cells from damage. (webmd.com)
  • I'm not impressed by what MICSC are doing, either: telling people there's something wrong with their brain, apparently without any scientific basis. (discovermagazine.com)
  • I saw changes that shouldn't be in a 50-year-old man's brains, and also changes that shouldn't be in a brain that looked normal. (pbs.org)
  • NIAID scientists at RML also have shown that, in response to damage to the brain, normal prion protein acquires properties similar to those of infectious prion protein. (nih.gov)
  • 11. Effect of chronic stress on tumorigenesis and development. (nih.gov)
  • Chronic stress damages the hippocampus , a brain area important for memory, spatial orientation and emotion regulation. (madinamerica.com)
  • Following a 2005 report of chromosomal damage in children with attention deficit/hyperactivity disorder (ADHD) who were treated with the commonly prescribed medication methylphenidate (MPH), numerous studies have been conducted to clarify the risk for MPH-induced genetic damage. (nih.gov)
  • Although most of these studies reported no changes in genetic damage endpoints associated with exposure to MPH, one recent study (Andreazza et al. (nih.gov)
  • It's a type of brain damage that has left the former multiple match of the night winner struggling with memory lapses and depression . (refresher.com)
  • Chronic bloody diarrhea and difficulty swallowing leads to poor growth. (nih.gov)
  • Social deprivation is bad for brain structure and function. (madinamerica.com)
  • Sensory deprivation is bad for brain structure and function. (madinamerica.com)
  • This research project leverages ongoing funded longitudinal studies examining brain function and development in cSLE, led by Dr. Andrea Knight, my primary mentor. (lupus.org)
  • It should be noted that new research is still ongoing in this area and the UFC itself has invested in a specialized clinic to learn more about brain damage . (refresher.com)
  • Blood vessel damage causes tiny red spots under the skin (petechiae) and blue discoloration in the hands and feet due to reduced blood flow (acrocyanosis). (nih.gov)