Brachyspira hyodysenteriae. Medical search

A species of anaerobic, spiral bacteria that was formerly classified as Serpulina hyodysenteriae and Treponema hyodysenteriae (and for a short while, Serpula hyodysenteriae). This organism is the agent of swine dysentery.

A genus of spiral bacteria of the family Brachyspiraceae.

Infections with bacteria of the order SPIROCHAETALES.

An order of slender, flexuous, helically coiled bacteria, with one or more complete turns in the helix.

Acute inflammation of the intestine associated with infectious DIARRHEA of various etiologies, generally acquired by eating contaminated food containing TOXINS, BIOLOGICAL derived from BACTERIA or other microorganisms. Dysentery is characterized initially by watery FECES then by bloody mucoid stools. It is often associated with ABDOMINAL PAIN; FEVER; and DEHYDRATION.

Diseases of domestic swine and of the wild boar of the genus Sus.

Infections with bacteria of the family Desulfovibrionaceae.

Infections with bacteria of the genus TREPONEMA.

Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.

A genus of gram-negative, obligate intracellular bacteria causing a proliferative enteritis in animals, especially pigs, deer, horses, and rabbits.

A genus of microorganisms of the order SPIROCHAETALES, many of which are pathogenic and parasitic for man and animals.

Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).

A family of spiral bacteria of the order SPIROCHAETALES.

An antibacterial agent that has been used in veterinary practice for treating swine dysentery and enteritis and for promoting growth. However, its use has been prohibited in the UK following reports of carcinogenicity and mutagenicity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p125)

A genus of flexible, spiral rods found in hydrogen sulfide-containing mud, sewage, and polluted water. None of the species properly referred to in this genus are pathogenic.

Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.

The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX.

The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed)

A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.

Diagnostic procedures, such as laboratory tests and x-rays, routinely performed on all individuals or specified categories of individuals in a specified situation, e.g., patients being admitted to the hospital. These include routine tests administered to neonates.

A cell-separation technique where magnetizable microspheres or beads are first coated with monoclonal antibody, allowed to search and bind to target cells, and are then selectively removed when passed through a magnetic field. Among other applications, the technique is commonly used to remove tumor cells from the marrow (BONE MARROW PURGING) of patients who are to undergo autologous bone marrow transplantation.

Procedures, such as TISSUE CULTURE TECHNIQUES; mathematical models; etc., when used or advocated for use in place of the use of animals in research or diagnostic laboratories.

The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.

The protection of animals in laboratories or other specific environments by promoting their health through better nutrition, housing, and care.

The use of animals as investigational subjects.

Alternatives to the use of animals in research, testing, and education. The alternatives may include reduction in the number of animals used, replacement of animals with a non-animal model or with animals of a species lower phylogenetically, or refinement of methods to minimize pain and distress of animals used.

Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).

A reflex wherein impulses are conveyed from the cupulas of the SEMICIRCULAR CANALS and from the OTOLITHIC MEMBRANE of the SACCULE AND UTRICLE via the VESTIBULAR NUCLEI of the BRAIN STEM and the median longitudinal fasciculus to the OCULOMOTOR NERVE nuclei. It functions to maintain a stable retinal image during head rotation by generating appropriate compensatory EYE MOVEMENTS.

Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.

A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.

Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.

A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.

A hemeprotein that catalyzes the oxidation of the iodide radical to iodine with the subsequent iodination of many organic compounds, particularly proteins. EC 1.11.1.8.

A group of metabolites derived from THYROXINE and TRIIODOTHYRONINE via the peripheral enzymatic removal of iodines from the thyroxine nucleus. Thyronine is the thyroxine nucleus devoid of its four iodine atoms.

Exclusive legal rights or privileges applied to inventions, plants, etc.

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.

A metabolite of THYROXINE, formed by the peripheral enzymatic monodeiodination of T4 at the 5 position of the inner ring of the iodothyronine nucleus.

Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.

An acute inflammation of the INTESTINAL MUCOSA that is characterized by the presence of pseudomembranes or plaques in the SMALL INTESTINE (pseudomembranous enteritis) and the LARGE INTESTINE (pseudomembranous colitis). It is commonly associated with antibiotic therapy and CLOSTRIDIUM DIFFICILE colonization.

An enzyme that catalyzes the conversion of L-glutamate and water to 2-oxoglutarate and NH3 in the presence of NAD+. (From Enzyme Nomenclature, 1992) EC 1.4.1.2.

A common inhabitant of the colon flora in human infants and sometimes in adults. It produces a toxin that causes pseudomembranous enterocolitis (ENTEROCOLITIS, PSEUDOMEMBRANOUS) in patients receiving antibiotic therapy.

People who take drugs for a non-therapeutic or non-medical effect. The drugs may be legal or illegal, but their use often results in adverse medical, legal, or social consequences for the users.

The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Analysis of Serpulina hyodysenteriae strain variation and its molecular epidemiology using pulsed-field gel electrophoresis. (1/81)

Pulsed-field gel electrophoresis (PFGE) was applied as a molecular typing tool for the spirochaete Serpulina hyodysenteriae, the agent of swine dysentery. Analysis of a collection of 40 mainly Australian isolates, previously characterized by other methods, divided these into 23 PFGE types. This confirmed that there are many strains of the spirochaete in Australia. PFGE was more discriminatory for strain typing than both multilocus enzyme electrophoresis and serotyping. It had similar discriminatory power to restriction endonuclease analysis, but the results of PFGE were easier to interpret. When applied to 29 isolates collected from 4 farms over periods of up to 8 years, 2 PFGE patterns were found on 3 farms, and a single pattern on the other. In each case a new strain had apparently emerged as a variant of an original parent strain. PFGE was found to be a powerful technique for investigating the molecular epidemiology of swine dysentery outbreaks. (+info)

A comparison of the morphologic effects of Serpulina hyodysenteriae or its beta-hemolysin on the murine cecal mucosa. (2/81)

Studies were carried out to compare the early morphologic changes in the cecal mucosa of mice either infected with Serpulina hyodysenteriae or exposed to the beta-hemolysin of S. hyodysenteriae. Sixty-five 12-24-week-old C3H/HeOuJ mice were infected with S. hyodysenteriae by gastric intubation. Two mice were necropsied every hour for 30 hours following infection. S. hyodysenteriae was isolated from the cecal contents of each mouse at all time points. Macroscopic lesions were first apparent at 14 hours postinfection (PI), and light microscopic lesions were first apparent at 10 hours PI, earlier than has been previously reported. Ultrastructural changes, first evident at 6 hours PI, included disarray and loss of microvilli and terminal web, with dilatation of intercellular spaces. Luminal bacteria were translocated through epithelial cells to the lamina propria, where capillaries exhibited changes indicative of increased permeability. In another experiment, solutions containing between 2,500 and 25,000 hemolytic units of purified S. hyodysenteriae hemolysin were placed within the lumen of surgically closed murine ceca (n = 10); ceca were collected for examination 3 hours following treatment. Ultrastructural changes consisted of loss of microvilli and terminal web and marked vacuolation and exfoliation of epithelial cells. Significant numbers of necrotic and apoptotic epithelial cells were present, and epithelial cells internalized moderate numbers of bacteria. The hemolysin of S. hyodysenteriae induces some of the same early ultrastructural changes in the cecal epithelium of mice as occur following infection with S. hyodysenteriae. Based on the observed bacterial translocation, luminal bacteria also appear to play a unique role in lesion development in this model. (+info)

Isolation, oxygen sensitivity, and virulence of NADH oxidase mutants of the anaerobic spirochete Brachyspira (Serpulina) hyodysenteriae, etiologic agent of swine dysentery. (3/81)

Brachyspira (Serpulina) hyodysenteriae, the etiologic agent of swine dysentery, uses the enzyme NADH oxidase to consume oxygen. To investigate possible roles for NADH oxidase in the growth and virulence of this anaerobic spirochete, mutant strains deficient in oxidase activity were isolated and characterized. The cloned NADH oxidase gene (nox; GenBank accession no. U19610) on plasmid pER218 was inactivated by replacing 321 bp of coding sequence with either a gene for chloramphenicol resistance (cat) or a gene for kanamycin resistance (kan). The resulting plasmids, respectively, pCmDeltaNOX and pKmDeltaNOX, were used to transform wild-type B. hyodysenteriae B204 cells and generate the antibiotic-resistant strains Nox-Cm and Nox-Km. PCR and Southern hybridization analyses indicated that the chromosomal wild-type nox genes in these strains had been replaced, through allelic exchange, by the inactivated nox gene containing cat or kan. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western immunoblot analysis revealed that both nox mutant cell lysates were missing the 48-kDa Nox protein. Soluble NADH oxidase activity levels in cell lysates of Nox-Cm and Nox-Km were reduced 92 to 96% compared to the activity level in parent strain B204. In an aerotolerance test, cells of both nox mutants were at least 100-fold more sensitive to oxygen exposure than were cells of the wild-type parent strain B204. In swine experimental infections, both nox mutants were less virulent than strain B204 in that fewer animals were colonized by the mutant cells and infected animals displayed mild, transient signs of disease, with no deaths. These results provide evidence that NADH oxidase serves to protect B. hyodysenteriae cells against oxygen toxicity and that the enzyme, in that role, contributes to the pathogenic ability of the spirochete. (+info)

Characterization of a periplasmic ATP-binding cassette iron import system of Brachyspira (Serpulina) hyodysenteriae. (4/81)

The nucleotide sequence of the pathogenic spirochete Brachyspira hyodysenteriae bit (for "Brachyspira iron transport") genomic region has been determined. The bit region is likely to encode an iron ATP-binding cassette transport system with some homology to those encountered in gram-negative bacteria. Six open reading frames oriented in the same direction and physically linked have been identified. This system possesses a protein containing ATP-binding motifs (BitD), two hydrophobic cytoplasmic membrane permeases (BitE and BitF), and at least three lipoproteins (BitA, BitB, and BitC) with homology to iron periplasmic binding proteins. These periplasmic binding proteins exhibit lipoprotein features. They are labeled by [(3)H]palmitate when tested in recombinant Escherichia coli, and their signal peptides are typical for substrates of the type II secretory peptidase. The FURTA system and Congo red assay indicate that BitB and BitC are involved in iron binding. The Bit system is detected only in B. hyodysenteriae and is absent from B. innocens and B. pilosicoli. (+info)

Changes in bacterial community structure in the colon of pigs fed different experimental diets and after infection with Brachyspira hyodysenteriae. (5/81)

Bacterial communities in the large intestines of pigs were compared using terminal restriction fragment length polymorphism (T-RFLP) analysis targeting the 16S ribosomal DNA. The pigs were fed different experimental diets based on either modified standard feed or cooked rice supplemented with dietary fibers. After feeding of the animals with the experimental diets for 2 weeks, differences in the bacterial community structure in the spiral colon were detected in the form of different profiles of terminal restriction fragments (T-RFs). Some of the T-RFs were universally distributed, i.e., they were found in all samples, while others varied in distribution and were related to specific diets. The reproducibility of the T-RFLP profiles between individual animals within the diet groups was high. In the control group, the profiles remained unchanged throughout the experiment and were similar between two independent but identical experiments. When the animals were experimentally infected with Brachyspira hyodysenteriae, causing swine dysentery, many of the T-RFs fluctuated, suggesting a destabilization of the microbial community. (+info)

The spirochete FlaA periplasmic flagellar sheath protein impacts flagellar helicity. (6/81)

Spirochete periplasmic flagella (PFs), including those from Brachyspira (Serpulina), Spirochaeta, Treponema, and Leptospira spp., have a unique structure. In most spirochete species, the periplasmic flagellar filaments consist of a core of at least three proteins (FlaB1, FlaB2, and FlaB3) and a sheath protein (FlaA). Each of these proteins is encoded by a separate gene. Using Brachyspira hyodysenteriae as a model system for analyzing PF function by allelic exchange mutagenesis, we analyzed purified PFs from previously constructed flaA::cat, flaA::kan, and flaB1::kan mutants and newly constructed flaB2::cat and flaB3::cat mutants. We investigated whether any of these mutants had a loss of motility and altered PF structure. As formerly found with flaA::cat, flaA::kan, and flaB1::kan mutants, flaB2::cat and flaB3::cat mutants were still motile, but all were less motile than the wild-type strain, using a swarm-plate assay. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot analysis indicated that each mutation resulted in the specific loss of the cognate gene product in the assembled purified PFs. Consistent with these results, Northern blot analysis indicated that each flagellar filament gene was monocistronic. In contrast to previous results that analyzed PFs attached to disrupted cells, purified PFs from a flaA::cat mutant were significantly thinner (19.6 nm) than those of the wild-type strain and flaB1::kan, flaB2::cat, and flaB3::cat mutants (24 to 25 nm). These results provide supportive genetic evidence that FlaA forms a sheath around the FlaB core. Using high-magnification dark-field microscopy, we also found that flaA::cat and flaA::kan mutants produced PFs with a smaller helix pitch and helix diameter compared to the wild-type strain and flaB mutants. These results indicate that the interaction of FlaA with the FlaB core impacts periplasmic flagellar helical morphology. (+info)

Antigen-specific proliferation of porcine CD8alphaalpha cells to an extracellular bacterial pathogen. (7/81)

A vaccine inducing protective immunity to a spirochaete-induced colitis of pigs predominantly stimulates expansion of CD8+ cells in vivo and in antigen-stimulated lymphocyte cultures. CD8+ cells, however, are rarely considered necessary for protection against extracellular bacterial pathogens. In the present study, pigs recovering from colitis resulting from experimental infection with Brachyspira (Serpulina) hyodysenteriae had increased percentages of peripheral blood CD4- CD8+ (alphaalpha-expressing) cells compared with non-infected pigs. CD8alphaalpha+ cells proliferated in antigen-stimulated cultures of peripheral blood mononuclear cells from B. hyodysenteriae-vaccinated pigs. Proliferating CD8alphaalpha+ cells consisted of CD4-, CD4+ and gammadelta T-cell receptor-positive cells. CD4- CD8alphabeta+ cells from vaccinated or infected pigs did not proliferate upon in vitro antigen stimulation. Of the CD8alphaalpha cells that had proliferated, flow cytometric analysis indicated that the majority of the CD4+ CD8+ cells were large (i.e. lymphoblasts) whereas the CD4- CD8+ cells were predominantly small. Addition of monoclonal antibodies (mAb) specific for either porcine major histocompatibility complex (MHC) class I or class II antigens diminished B. hyodysenteriae-specific proliferative responses whereas addition of mAb to porcine MHC II, but not porcine MHC I, reduced the CD8alphaalpha response. In vitro depletion of CD4+ cells by flow cytometric cell sorting diminished, but did not completely abrogate, the proliferative response of cells from vaccinated pigs to B. hyodysenteriae antigen stimulation. These results suggest that CD8alphaalpha cells are involved in recovery and possibly protection from a spirochaete-induced colitis of pigs; yet, this response appears to be partially dependent upon CD4+ cells. (+info)

Cloning of a beta-hemolysin gene of Brachyspira (Serpulina) hyodysenteriae and its expression in Escherichia coli. (8/81)

Brachyspira (Serpulina) hyodysenteriae induces a mucohemorrhagic diarrheal disease in pigs. The production of a beta-hemolysin has been considered a major virulence attribute of this organism. Previous reports have failed to correlate a specific cloned gene sequence with a purified beta-hemolytic protein sequence. Thus, questions still remain concerning the structural gene sequence of the hemolysin. To answer this question unequivocally, the beta-hemolytic toxin was purified from extracts of log-phase spirochetes, and the N-terminal amino acid sequence was determined (K-D-V-V-A-N-Q-L-N-I-S-D-K) and compared with the translated sequences of previously cloned genes, tlyA to tlyC. The lack of homology between tlyA to tlyC translated sequences and the purified beta-hemolytic toxin sequence resulted in the study that is reported here. A degenerate probe was designed based on the N-terminal amino acid sequence of the purified beta-hemolysin and used to screen a B. hyodysenteriae genomic library. Three overlapping clones were identified, and one was sequenced to reveal an open reading frame coding for a putative 8.93-kDa polypeptide containing the N-terminal sequence of the purified beta-hemolysin. To distinguish this gene from the tlyA to tlyC genes, it has been designated hlyA. A hemolysis-negative Escherichia coli strains containing hlyA was beta-hemolytic on blood agar media. Also, the hemolytic activity of the recombinant protein had identical protease and lipase sensitivities and electrophoretic mobility to those of native B. hyodysenteriae beta-hemolysin. Based on sequence analysis, the translated protein had a pI of 4.3, an alpha-helical structure, and a phosphopantetheine binding motif. Hybridization analysis of genomic DNA indicated that the hlyA gene was present in B. hyodysenteriae and B. intermedia but was not detected in B. innocens, B. pilosicoli, or B. murdochii under high-stringency conditions. The location of hlyA on the chromosomal map was distinct from the locations of tlyA, tlyB, and tlyC. (+info)

Porcine and avian intestinal spirochetosis are caused by Brachyspira hyodysenteriae and Brachyspira pilosicoli. It is diagnosed ... Human intestinal spirochetosis is caused by Brachyspira pilosicoli and Brachyspira aalborgi. ...

https://en.wikipedia.org/wiki/Intestinal_spirochetosis

... and proposals of Brachyspira hyodysenteriae Comb. Nov., Brachyspira innocens Comb. Nov. and Brachyspira pilosicoli Comb. Nov". ... Both species however are classified as belonging to the genus Brachyspira, together with Brachyspira pilosicoli. They are ... nov., as Serpula hyodysenteriae comb. nov. and Serpula innocens comb. nov". International Journal of Systematic Bacteriology. ... Containing the Species Serpulina hyodysenteriae comb. nov. and Serpulina innocens comb. nov". International Journal of ...

https://en.wikipedia.org/wiki/Serpulina_innocens

Brachyspira hyodysenteriae and Brachyspira pilosicoli. Infection causes mild gastrointestinal signs in young pigs and can also ...

https://en.wikipedia.org/wiki/Porcine_intestinal_spirochaetosis

... genes associated with prophage-like gene transfer agents in the pathogenic intestinal spirochaetes Brachyspira hyodysenteriae, ... Brachyspira pilosicoli and Brachyspira intermedia". Veterinary Microbiology. 134 (3-4): 340-5. doi:10.1016/j.vetmic.2008.09.051 ... Brachyspira is a genus of spirochete; several species have been shown to carry homologous GTA gene clusters. Particles contain ... Brachyspira, and Rhodobacter species". Anaerobe. 13 (2): 43-9. doi:10.1016/j.anaerobe.2007.03.004. PMID 17513139. Grüll MP, ...

https://en.wikipedia.org/wiki/Gene_transfer_agent

... hyodysenteriae or Brachyspira pilosicoli by PCR. Brachyspira species previously capable of weak hemolysis only, like B. ... Antimicrobial susceptibility of porcine Brachyspira hyodysenteriae and Brachyspira pilosicoli isolated in Sweden between 1990 ... Brachyspira are capable of hemolysis, the degree of which has been used to characterize them, with B. hyodysenteriae showing ... Zmudzki J, Szczotka A, Nowak A, Strzelecka H, Grzesiak A, Pejsak Z.Antimicrobial susceptibility of Brachyspira hyodysenteriae ...

https://en.wikipedia.org/wiki/Brachyspira

... and proposals of Brachyspira hyodysenteriae Comb. Nov., Brachyspira innocens Comb. Nov. and Brachyspira pilosicoli Comb. Nov". ... Casas V, Vadillo S, San Juan C, Carrascal M, Abian J (2016-07-21). "The Exposed Proteomes of Brachyspira hyodysenteriae and B. ... Mikosza AS, La T, Margawani KR, Brooke CJ, Hampson DJ (April 2001). "PCR detection of Brachyspira aalborgi and Brachyspira ... Hidalgo A, Rubio P, Osorio J, Carvajal A (December 2010). "Prevalence of Brachyspira pilosicoli and "Brachyspira canis" in dogs ...

https://en.wikipedia.org/wiki/Brachyspira_pilosicoli

... , formerly known as Brachyspira hyodysenteriae and Treponema hyodysenteriae, is a species of bacteria. ... Harris DL; Glock RD; Christensen CR; Kinyon JM (January 1972). "Inoculation of pigs with Treponema hyodysenteriae (new species ...

https://en.wikipedia.org/wiki/Serpulina_hyodysenteriae

The Brachyspira holin (B-Hol) Family (TC# 1.E.55) consists of several proteins from the GTA holin of Brachyspira hyodysenteriae ... a prophage-like gene transfer agent of Brachyspira hyodysenteriae". Journal of Bacteriology 187 (17): 5885-5892. doi:10.1128/JB ... Biology portal As of this edit, this article uses content from "1.E.55 The Brachyspira holin (B-Hol) Family", which is licensed ... "1.E.55 The Brachyspira holin (B-Hol) Family". TCDB. Retrieved 2016-03-29. ...

https://en.wikipedia.org/wiki/Brachyspira_holin_family

Methane metabolism - Brachyspira hyodysenteriae WA1 [ Pathway menu , Organism menu , Pathway entry , Download KGML , Show ...

http://www.genome.jp/kegg-bin/show_pathway?bhy00680+BHWA1_01885

... formerly Serpulina hyodysenteriae) isolates. The genetic basis of macrolide and lincosamide resistance in B. hyodysenteriae was ... Resistance to tylosin, erythromycin and clindamycin in B. hyodysenteriae was ass … ... Macrolide antibiotic resistance is widespread among Brachyspira hyodysenteriae ( ... Macrolide antibiotic resistance is widespread among Brachyspira hyodysenteriae (formerly Serpulina hyodysenteriae) isolates. ...

https://pubmed.ncbi.nlm.nih.gov/10188254/?dopt=Abstract

The most common aetiological agent is the anaerobic intestinal spirochaete Brachyspira hyodysenteriae.The related... ... Identification of Brachyspira hyodysenteriae and other pathogenic Brachyspira species in chickens from laying flocks with ... Development of a duplex PCR assay for the detection of Brachyspira hyodysenteriae and Brachyspira pilosicoli in pig feces. J ... although in some regions the related species Brachyspira hampsonii and Brachyspira suanatina also may cause SD [2]. Brachyspira ...

https://link.springer.com/article/10.1186%2Fs40813-019-0133-x

Results reported on Tuesdays. The specimen type(s) listed for this test will provide an adequate sample volume to conduct this test. If multiple tests are to be requested on a specimen, there may not be adequate sample volume to perform each test. Please submit an adequate sample volume to meet the requirements of each test. If multiple agent testing is requested, please submit 2 tablespoons/30ml of fecal material. This will allow for an adequate sample volume to properly conduct each test.. Brachyspira PCR Fact Sheet. ...

https://www.vdl.umn.edu/node/12906

... being Brachyspira intermedia, Brachyspira pilosicoli, Brachyspira alvinipulli and Brachyspira hyodysenteriae, and one or more ... Diagnóstico de Brachyspira pilosicoli, Brachyspira hyodysenteriae e Brachyspira intermedia em aves de postura e matrizes de ... Diagnosis of Brachyspira pilosicoli, Brachyspira hyodysenteriae and Brachyspira intermedia in hens and laying hens in the ... INDEX TERMS: Brachyspira pilosicoli; Brachyspira hyodysenteriae; Brachyspira intermedia; hens; laying hens; Paraná; bacterial ...

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2019000700476&tlng=en

Brachyspira (Serpulina)hyodysenteriae, the etiologic agent of swine dysentery, uses the enzyme NADH oxidase to consume oxygen. ... Brachyspira(Serpulina) hyodysenteriae cells colonize the oxygen-respiring mucosal tissues of the swine cecum and colon. During ... Results with B. hyodysenteriaeB204 (wild type) (A) and B. hyodysenteriae Nox-Km (nox mutant) (B) are shown. Two-microliter ... Derivation of B. hyodysenteriae nox mutants.Transformation of B. hyodysenteriae B204 cells by electroporation was based on ...

https://aem.asm.org/content/65/11/5028

For swine dysentery, which is caused by Brachyspira hyodysenteriae infection and is an economically important disease in ... For swine dysentery, which is caused by Brachyspira hyodysenteriae infection and is an economically important disease in ... Estimating diagnostic test accuracies for brachyspira hyodysenteriae accounting for the complexities of population structure in ... Estimating diagnostic test accuracies for brachyspira hyodysenteriae accounting for the complexities of population structure in ...

https://www.zora.uzh.ch/id/eprint/104202/

... hyodysenteriae farm strains. This study highlights the potential role of shipments in B. hyodysenteriae spread. Moreover, it ... The objective of this study was to investigate the role of slaughterhouse vehicles in spreading B. hyodysenteriae between ... hyodysenteriae genetic profiles. STVT 83-3, which seems to be the current dominant type in Italy, was identified in 56.25% of ... hyodysenteriae, followed by categories 4 and 3 with 85.7% and 83.3%, respectively. The results of MLST and MLVA suggest that ...

https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-017-1328-5

Changes in the content of neuropeptides in intestinal lymph nodes of pigs suffering from experimental Brachyspira ... hyodysenteriae infection , M. Lakomy, A. Winnicka, K. Wasowicz, J. Zmudzki, J. Kaleczyc, W. Sienkiewicz, P. Podlasz , ... in 4-months old pigs in which experimental enteritis was induced with Brachyspira hyodysenteriae infection, a statistically ... in the content of neuropeptides in intestinal lymph nodes of pigs suffering from experimental Brachyspira hyodysenteriae ...

https://www.agriculturejournals.cz/web/vetmed.htm?type=article&id=98_2009-VETMED

In pigs, seven Brachyspira spp. have been described, i.e. B. hyodysenteriae, B. pilosicoli, B. intermedia, B. murdochii, B. ... Brachyspira hyodysenteriae is especially relevant in pigs as it causes swine dysentery and hence considerable economic losses ... A review of methods used for studying the molecular epidemiology of Brachyspira hyodysenteriae.. ... This review is based on papers published in the field of epidemiology and molecular epidemiology of B. hyodysenteriae in pigs. ...

https://www.pacb.com/publications/a-review-of-methods-used-for-studying-the-molecular-epidemiology-of-brachyspira-hyodysenteriae/

Brachyspira hyodysenteriae, Brachyspira hyodysenteriae WA1, Brachyspira hyodysenteriae str. WA1, Brachyspira hyodysenteriae ... Brachyspira hyodysenteriae. NCBI taxonomy Id: 565034. Other names: B. hyodysenteriae WA1, ...

https://string-db.org/network/565034.BHWA1_00468

Antimicrobial susceptibility testing of Australian isolates of Brachyspira hyodysenteriae using a new broth dilution method ... The antimicrobial susceptibilities of 76 field isolates of Brachyspira hyodysenteriae from different states of Australia were ... 2002) Antimicrobial susceptibility testing of Australian isolates of Brachyspira hyodysenteriae using a new broth dilution ...

http://researchrepository.murdoch.edu.au/id/eprint/12712/

Animals , Swine Diseases/diagnosis , Gram-Negative Bacterial Infections , Brachyspira hyodysenteriae , Brachyspira , Sus scrofa ... Brachyspira hyodysenteriae / Brachyspira / Sus scrofa / Dysentery Clinical aspect: Diagnosis Limits: Animals Language: ... Disenteria Suína e Colite Espiroquetal são duas enfermidades importantes em suínos causados pela Brachyspira hyodysenteriae e ... Hibridização in situ fluorescente para diagnóstico de Brachyspira hyodysenteriae e B. pilosicoli -em suínos / Fluorescence in ...

https://search.bvsalud.org/gim/resource/en/biblio-895346

Virulence of strong and weakly haemolytic strains of Brachyspira hyodysenteriae. . Biblioteca virtual para leer y descargar ... Virulence of strong and weakly haemolytic strains of Brachyspira hyodysenteriae - Descarga este documento en PDF. Documentación ...

http://libros.duhnnae.com/2017/aug6/150280538946-Virulence-of-strong-and-weakly-haemolytic-strains-of-Brachyspira-hyodysenteriae.php

... study was to compare the relative sensitivity of IMS for isolation of Brachyspira pilosicoli and Brachyspira hyodysenteriae ... Further development of IMS techniques is required to improve isolation rates of Brachyspira species from faecal samples. ... Immunomagnetic separation of the intestinal spirochaetes Brachyspira pilosicoli and Brachyspira hyodysenteriae from porcine ... Immunomagnetic separation of the intestinal spirochaetes Brachyspira pilosicoli and Brachyspira hyodysenteriae from porcine ...

https://www.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.05500-0

Brachyspira hyodysenteriae 1 (5-phosphoribosyl) 5 [ (5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase ... Brachyspira hyodysenteriae 1- (5-phosphoribosyl) -5-[ (5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide ... Brachyspira hyodysenteriae 1- (5-phosphoribosyl) -5-[ (5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide ... Recombinant Brachyspira hyodysenteriae 1- (5-phosphoribosyl) -5-[ (5-phosphoribosylamino) methylideneamino] imidazole-4- ...

https://gentaursearch.com/product/human/882824/brachyspira-hyodysenteriae-1-5-phosphoribosyl-5-5-phosphoribosylamino-methylideneamino-imidazole-4-carboxamide-isomerase.html

https://en.wikipedia.org/wiki/Brachyspira_pilosicoli

Except for Brachyspira hyodysenteriae, the clinical significance of these in vitro activities is unknown. ... Tiamulin is active against Brachyspira hyodysenteriae. The antibacterial activity of tiamulin is due to its inhibitory effects ... Denagard Injection is effective for treatment of swine dysentery associated with Brachyspira hyodysenteriae susceptible to ...

https://www.drugs.com/vet/denagard-injection-can.html

https://en.wikipedia.org/wiki/Brachyspira

Full text: Available Index: LILACS (Americas) Main subject: Microbial Sensitivity Tests / Brachyspira hyodysenteriae / NADPH ... Full text: Available Index: LILACS (Americas) Main subject: Microbial Sensitivity Tests / Brachyspira hyodysenteriae / NADPH ... Minimum inhibitory concentration of Brazilian Brachyspira hyodysenteriae strains Minimum inhibitory concentration of Brazilian ... Brachyspira hyodysenteriae strains / Concentração inibitória mínima de cepas Brachyspira hyodysenteriae brasileiras Daniel, ...

https://search.bvsalud.org/gim/resource/en/biblio-895411

Identification of the gene encoding BmpB, a 30 kDa outer envelope lipoprotein of Brachyspira (Serpulina) hyodysenteriae, and ... 2000) Identification of the gene encoding BmpB, a 30 kDa outer envelope lipoprotein of Brachyspira (Serpulina) hyodysenteriae, ... A gene encoding a 30 kDa outer envelope protein of the intestinal spirochaete Brachyspira (Serpulina) hyodysenteriae, was ... Sera from these mice and pigs recognised the 30 kDa lipoprotein in outer membrane preparations of B. hyodysenteriae, indicating ...

https://researchrepository.murdoch.edu.au/id/eprint/9758/

All eight genes previously associated with haemolysis in B. hyodysenteriae were present in the whBh. No consistent patterns of ... Typical strains of B. hyodysenteriae are strongly haemolytic on blood agar, and the haemolytic activity is believed to ... However, recently there have been reports of atypical weakly haemolytic isolates of B. hyodysenteriae (whBh). In this study, 34 ... hyodysenteriae. Another difference in this region was the presence of three CDSs in whBh that are pseudogenes in strongly ...

https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-019-0639-x/tables/1

We evaluated the susceptibility of B. hyodysenteriae, B. hampsonii, Brachyspira pilosicoli, and Brachyspira murdochii to ... Outbreaks of swine dysentery, caused by Brachyspira hyodysenteriae and the recently discovered "Brachyspira hampsonii," have ... Antimicrobial susceptibility of porcine Brachyspira hyodysenteriae and Brachyspira pilosicoli isolated in Sweden between 1990 ... Multiresistant Brachyspira hyodysenteriae in a Dutch sow herd. Tijdschr Diergeneeskd 133:604-608. (In Dutch.). ...

https://jcm.asm.org/content/54/8/2109

An update of Brachyspira hyodysenteriae serotyping.. Res Vet Sci. 2017 111: 135-139.. Herbst W, Willems H. (2017). Detection of ... Phylogenetic diversity, antimicrobial susceptibility and virulence gene profiles of Brachyspira hyodysenteriae isolates from ... Isolation and antimicrobial susceptibility of Brachyspira species from feces of layer chickens in Germany. Tierarztl Prax Ausg ...

http://www.uni-giessen.de/fbz/fb10/institute_klinikum/institute/ihit/Forschung/Publikationen

A water extract of Thyme inhibited Brachyspira hyodysenteriae, the causative agent of swine dysentery.Nov 30, 2016. ...

https://www.greenmedinfo.com/substance/thyme

Genes and proteins of brachyspira hyodysenteriae and uses thereof. EP3147365A1. Apr 20, 2007. Mar 29, 2017. Intervet ... Genes and proteins of brachyspira hyodysenteriae and use of same for diagnosis and therapy. ... Sequences of brachyspira, immunogenic composition, methods for preparation and use thereof. EP2636743A1. Apr 20, 2007. Sep 11, ... Novel sequences of brachyspira, immunogenic compositions, methods for preparation and use thereof. ...

http://www.google.com/patents/US4399121?dq=7143430

... prevention of swine dysentery associated with Brachyspira hyodysenteriae; control of swine pneumonias caused by bacterial ...

https://www.drugs.com/vet/tylan-40-sulfa-g.html

The essential causal agent is Brachyspira hyodysenteriae, an anaerobic spirochete that produces a hemolysin, although other ... Brachyspira sp SASK 30446, and B hampsonii. The Brachyspira proliferate in the large intestine and causes degeneration and ... B hyodysenteriae produces strong β hemolysis on blood agar under anaerobic incubation conditions. Other strongly β-hemolytic ... Mice are an important reservoir of infection for B hyodysenteriae, and any eradication attempt must include elimination/ ...

https://www.merckvetmanual.com/digestive-system/intestinal-diseases-in-pigs/swine-dysentery

Brachyspira contains Hemolysin. The more ____ the bacteria, the more chance that it will be associated with bad disease ... What virulence factor is necessary for Brachyspira and allows the bacteria to move through intestinal mucosa? ... What are the differentials for Brachyspira Hyodysenteriea that are hard to differentiate? ... The more virulent the strain of Brachyspira, the more ____ on blood agar ...

https://www.brainscape.com/flashcards/brachyspira-3058921/packs/4890933

Brachyspira hyodysenteriae ‎ *15:35, 13 August 2013 (diff , hist) . . (+14)‎ . . Body Odor ‎ (current) ...

https://microbewiki.kenyon.edu/index.php?title=Special:Contributions/BarichD&offset=20130813160045&limit=500&target=BarichD

The related spirochaete Brachyspira pilosicoli causes a milder form of colitis. (springer.com)
We report the first isolation of B. hyodysenteriae and B. pilosicoli from a pig farm in Hong Kong. (springer.com)
The samples were subjected to selective anaerobic culture and PCR for B. hyodysenteriae and B. pilosicoli , and two isolates of both species were obtained. (springer.com)
The B. hyodysenteriae isolates showed clinical resistance to tylosin and lincomycin, whilst the B. pilosicoli isolates were resistant to tylosin and showed intermediate susceptibility to lincomycin. (springer.com)
In this short communication, we describe the isolation and characterisation of B. hyodysenteriae and B. pilosicoli from pig faeces on a farm in Hong Kong. (springer.com)
Diagnóstico de Brachyspira pilosicoli , Brachyspira hyodysenteriae e Brachyspira intermedia em aves de postura e matrizes de corte na região oeste do Paraná através do isolamento bacteriano e identificação na qPCR. (scielo.br)
through isolation and confirmation of the species Brachyspira pilosicoli , Brachyspira hyodysenteriae and Brachyspira intermedia using the qPCR technique. (scielo.br)
através do isolamento e confirmação das espécies Brachyspira pilosicoli, Brachyspira hyodysenteriae e Brachyspira intermedia utilizando a técnica de qPCR. (scielo.br)
Disenteria Suína e Colite Espiroquetal são duas enfermidades importantes em suínos causados pela Brachyspira hyodysenteriae e Brachyspira pilosicoli, respectivamente. (bvsalud.org)
Propõe-se avaliar a técnica de hibridização in situ de fluorescência (FISH) para detecção de B. hyodysenteriae e B. pilosicoli em fragmentos histopatológicos de intestino de suínos e compará- la ao PCR duplex. (bvsalud.org)
Baseado no fato dessa técnica poder ser realizada em tecidos formolizados, ser prática, rápida e associar a marcação especifica do agente com lesões histológicas, o FISH demonstrou ser mais uma alternativa no diagnóstico de Brachyspira hyodysenteriae e B. pilosicoli. (bvsalud.org)
This study aimed to evaluate the fluorescent in situ hybridization (FISH) for the diagnosis of B. hyodysenteriae and B. pilosicoli in histopathologic fragments of pig's intestine and compare it to the duplex PCR . (bvsalud.org)
Based on the fact this technique can be performed in formalin fixed tissue samples, it is practical, fast and allows the association of labeling a specific agent with histological lesions, FISH has become an alternative diagnostic method for Brachyspira hyodysenteriae and B. pilosicoli. (bvsalud.org)
The purpose of the present study was to compare the relative sensitivity of IMS for isolation of Brachyspira pilosicoli and Brachyspira hyodysenteriae with current routine diagnostic methods (culture on selective media and PCR) for detection of these micro-organisms in pig faeces. (microbiologyresearch.org)
We evaluated the susceptibility of B. hyodysenteriae , B. hampsonii , Brachyspira pilosicoli , and Brachyspira murdochii to tiamulin, valnemulin, doxycycline, lincomycin, and tylosin by broth microdilution and that to carbadox by agar dilution. (asm.org)
A milder enteric syndrome of chronic mucodiarrheal disease of grower-finisher pigs, termed porcine intestinal spirochetosis, is caused by Brachyspira pilosicoli ( 1 ). (asm.org)
Outbreaks of swine dysentery were diagnosed based on clinical presentation, bacterial isolation, gross and microscopic lesions, duplex PCR for B. hyodysenteriae and B. pilosicoli and nox gene sequencing. (bvsalud.org)
Surtos de disenteria suína foram diagnosticados com base na apresentação clínica, isolamento bacteriano, lesões macroscópicas e microscópicas, PCR duplex para B. hyodysenteriae e B. pilosicoli e sequenciamento do gene nox. (bvsalud.org)
Restriction endonuclease digested DNA's of twenty-seven spirochete strains representing six Brachyspira species (B. hyodysenteriae, B. innocens, B. pilosicoli, B. murdochii, B. intermedia, B. alvinipulli), contained a single fragment which hybridized with the svp38 gene probe. (usda.gov)
Brachyspira pilosicoli which is often associated with a less severe colitis and may also cause disease in chickens and humans. (thepigsite.com)
Brachyspira pilosicoli is a sporadic cause of colitis. (iastate.edu)
Brachyspira pilosicoli is a gram-negative, anaerobic, host-associated spirochete that colonizes the intestinal tract of animals and humans. (wikipedia.org)
B. pilosicoli is unique from other Brachyspira species because it colonizes a variety of domestic animals including pigs, chickens, dogs, wild birds, rodents, and humans. (wikipedia.org)
Although Spirochetes have been described dating back to 1877, it would be another hundred years before Brachyspira pilosicoli would be first described in 1980, and recognized as a causative agent of diarrhea and dysentery in pigs. (wikipedia.org)
Following these early descriptions, Brachyspira pilosicoli was discovered in various human populations including Asian communities, homosexual communities, and a wide variety of communities within Muscat, the capital of Oman. (wikipedia.org)
It wasn't until the mid-1990s that the pathogen was attributed to all three host species under the species name Brachyspira pilosicoli. (wikipedia.org)
Despite being isolated in other species, Brachyspira pilosicoli remains predominantly a spirochete associated with porcine intestinal spirochetosis. (wikipedia.org)
Brachyspira pilosicoli is a gram-negative, anaerobic, spirochete bacteria that is approximately 4 - 10 um in length and 0.2 - 0.3 um in width. (wikipedia.org)
In Sweden, 10-15% of B. pilosicoli isolates between 2002 and 2010 were resistant to tiamulin (MICs >4 μg/ml), and a gradual increase in tiamulin MICs was seen in B. hyodysenteriae between 1990 and 2003, which has since plateaued. (wikipedia.org)
Brachyspira: Brachyspira hyodysenteriae, B. pilosicoli. (hyperdrug.co.uk)
Performance (laying %) of a Brachyspira pilosicoli infected flock against the breed standard. (thepoultrysite.com)
Other Brachyspira spp were also isolated, such as B. hyodysenteriae (commonly associated with on-site pig production) and B. alvinipulli, which has mainly been reported in the USA, and is considered mildly pathogenic like B. pilosicoli. (thepoultrysite.com)
Brachyspira pilosicoli, however, was a good gut coloniser, as well as B. intermedia and B. hyodysenteriae. (thepoultrysite.com)
BACKGROUND: A multiplex qPCR targeting a 128 bp region on the 23S rDNA gene was developed for detection of Brachyspira (B.) hyodysenteriae and B. pilosicoli, the agents of swine dysentery (SD) and porcine intestinal spirochaetosis (PIS), together with a triplet of apathogenic Brachyspira spp. (uzh.ch)
D-ribose utilisation differentiates porcine Brachyspira pilosicoli from other porcine Brachyspira species. (evira.fi)
Brachyspira pilosicoli is an anaerobic spirochaete (bacterium) that colonizes the lumen and crypts of the large intestine of pigs, as well as a number of other animal species. (cabi.org)
Scanning electron micrograph showing the attachment of large numbers of Brachyspira pilosicoli cells to the surface of the colonic mucosa in an experimentally-infected pig. (cabi.org)
A variety of Brachyspira species can be detected in birds, but the pathogenic species in chickens are considered to be B. pilosicoli, intermedia and alvinipulli . (thepoultrysite.com)
PCR tests developed for pigs are of limited value in identifying species other than B. hyodysenteriae and pilosicoli , and although PCRs for avian Brachyspira species have been developed, the differentiation of the 'non-pathogenic' species remains problematic. (thepoultrysite.com)
Treatment of Porcine Colonic Spirochaetosis (colitis) caused by Brachyspira pilosicoli susceptible to tiamulin. (dechra.co.uk)
The report is a literature study to gain more insights in the role of feed in pig enteric bacterial diseases dysentery (Brachyspira hyodysenteriae), colitis (Brachyspira pilosicoli), ileitis (Lawsonia intracellularis) and salmonellosis (Salmonella typhimurium). (allaboutfeed.net)
BACKGROUND: The anaerobic spirochetes Brachyspira hyodysenteriae and Brachyspira pilosicoli cause diarrheal diseases in pigs. (usda.gov)

Brachyspira ( Serpulina ) hyodysenteriae , the etiologic agent of swine dysentery, uses the enzyme NADH oxidase to consume oxygen. (asm.org)
For swine dysentery, which is caused by Brachyspira hyodysenteriae infection and is an economically important disease in intensive pig production systems worldwide, a perfect or error-free diagnostic test (''gold standard'') is not available. (uzh.ch)
Brachyspira hyodysenteriae is especially relevant in pigs as it causes swine dysentery and hence considerable economic losses to the pig industry. (pacb.com)
A novel method for the isolation of Brachyspira ( Serpulina ) hyodysenteriae from pigs with swine dysentery in Italy. (microbiologyresearch.org)
Denagard Injection is effective for treatment of swine dysentery associated with Brachyspira hyodysenteriae susceptible to tiamulin when administered intramuscularly at 11 mg tiamulin per kilogram body weight once daily until clinical signs have disappeared or for a maximum of 4 days. (drugs.com)
Outbreaks of swine dysentery, caused by Brachyspira hyodysenteriae and the recently discovered " Brachyspira hampsonii ," have reoccurred in North American swine herds since the late 2000s. (asm.org)
The spirochete Brachyspira hyodysenteriae is considered to be the primary etiological agent of swine dysentery ( 1 ), but the advent of more-discriminatory microbiological methods has revealed considerable genetic diversity among Brachyspira species ( 2 - 4 ). (asm.org)
A decade ago, Brachyspira suanatina was isolated from pigs with dysentery-like disease in Sweden and Denmark ( 5 ). (asm.org)
More recently, a novel pathogenic species designated " Brachyspira hampsonii " was isolated in North America from cases of mucohemorrhagic diarrhea that were clinically indistinguishable from swine dysentery ( 3 ). (asm.org)
Pleuromutilins (tiamulin and valnemulin) have been used to treat and to control swine dysentery in many countries, due to their relatively short withdrawal periods and the sensitivity of Brachyspira species to them. (asm.org)
Other strongly β-hemolytic Brachyspira have been described that produce lesions of swine dysentery when inoculated into pigs, namely B suanatina , some strains of B intermedia, Brachyspira sp SASK 30446, and B hampsonii . (merckvetmanual.com)
Brachyspira hyodysenteriae is a helical-shaped bacterium that causes the disease swine dysentery. (usda.gov)
B. hyodysenteriae leads to diarrheal disease in growing pigs worldwide, causing the so-called swine dysentery, typhlocolitis or porcine intestinal spirochaetosis, which contributes to major "production losses" in agrobusiness. (wikipedia.org)
citation needed] Veterinary antibiotics used to treat pigs with dysentery due to Brachyspira species include the lincosamide lincomycin, the ionophore salinomycin, the quinoxaline carbadox, the pleuromodulins tiamulin and valnemulin, as well as the aminoglycoside gentamicin, an important antibiotic used in humans. (wikipedia.org)
Swine dysentery (SD) is a severe mucohaemorrhagic diarrheal disease of swine that has been recognised since the 1920s and is classically associated with infection by Brachyspira hyodysenteriae . (thepigsite.com)
Swine dysentery or bloody diarrhoea is a bacterial intestinal disease with varying clinical pictures caused by the anaerobic spirochete Brachyspira hyodysenteriae. (pigprogress.net)
For the treatment, prevention and control of swine dysentery caused by Brachyspira hyodysenteriae and complicated by Fusobacterium and Bacteroides spp. (hyperdrug.co.uk)
Swine dysentery, caused by Brachyspira hyodysenteriae , seemed to have gone through a relatively quiet patch and had almost disappeared in the US. (pigprogress.net)
In a similar situation, a group of six Saddleback weaners bought in three weeks earlier developed haemorrhagic diarrhoea, inappetence and poor growth and Brachyspira hyodysenteriae was isolated from a pooled faecal sample submitted to Langford, confirming a diagnosis of swine dysentery. (thepigsite.com)
Swine dysentery is a bacterial disease of pigs caused by Brachyspira hyodysenteriae. (npa-uk.org.uk)
An experiment was conducted to study the effect of diets with contrasting fermentability in the large intestine on experimental infections with Brachyspira hyodysenteriae, the causative agent of swine dysentery, and the whip worm, Trichuris suis, in pigs. (dtu.dk)
Pigs fed Diet 2 and challenged with B. hyodysenteriae did not develop swine dysentery and B. hyodysenteriae was not demonstrated in any of the pigs during the study. (dtu.dk)
In contrast, 94% of the B. hyodysenteriae challenged pigs fed Diet I showed clinical symptoms of swine dysentery and all the pigs were shedding B. hyodysenteriae in faeces at some points in time during the experiment. (dtu.dk)
Comparison of lesion severity, distribution, and colonic mucin expression in pigs with acute swine dysentery following oral inoculation with " Brachyspira hampsonii " or Brachyspira hyodysenteriae . (iastate.edu)
The authors described a weakly haemolytic intestinal spirochaete that was distinct from the strongly haemolytic spirochaete that causes swine dysentery (now known as Brachyspira hyodysenteriae ). (cabi.org)
The fructan-rich diet has previously been shown to prevent swine dysentery caused by Brachyspira hyodysenteriae. (dtu.dk)
Brachyspira hyodysenteriae causes swine dysentery (SD), leading to global financial losses to the pig industry. (readbyqxmd.com)
Treatment of Swine Dysentery caused by Brachyspira hyodysenteriae susceptible to tiamulin. (dechra.co.uk)
Knowledge of the cytokine response at infection with Brachyspira hyodysenteriae can help understanding disease mechanisme involved during swine dysentery. (biomedcentral.com)
B. hyodysenteriae inoculation induced production of systemic levels of IL-1β during the dysentery period and increased levels of IL-10 coincided with recovery from dysentery. (biomedcentral.com)

Brachyspira ( Serpulina ) hyodysenteriae cells colonize the oxygen-respiring mucosal tissues of the swine cecum and colon. (asm.org)
NADH oxidase has been viewed as a mechanism by which B. hyodysenteriae cells either contend with oxygen (as an antioxidant defense mechanism) or take advantage of oxygen (as an alternative NADH-regenerating pathway) in their native habitat, the oxygen-respiring tissues of the swine intestinal tract ( 40 , 41 ). (asm.org)
The objectives of our study were to determine the antimicrobial susceptibility trends of four Brachyspira species originating from U.S. swine herds and to investigate their associations with the bacterial species, genotypes, and epidemiological origins of the isolates. (asm.org)
Dr. Burrough's primary research focus is on Brachyspira- associated colitis of swine with projects investigating pathogenesis and the development of improved diagnostic techniques. (iastate.edu)
We characterized the swine colonic mucin O-glycome and identified the differences in glycosylation between B. hyodysenteriae-infected and noninfected pigs. (readbyqxmd.com)

The results of MLST and MLVA suggest that trucks transporting pigs from a high number of farms also play a critical role in spreading different B. hyodysenteriae genetic profiles. (biomedcentral.com)
Lakomy M., Winnicka A., Wasowicz K., Zmudzki J., Kaleczyc J., Sienkiewicz W., Podlasz P. (2009): Changes in the content of neuropeptides in intestinal lymph nodes of pigs suffering from experimental Brachyspira hyodysenteriae infection. (agriculturejournals.cz)
As compared to 4-months old pigs of the control group, in 4-months old pigs in which experimental enteritis was induced with Brachyspira hyodysenteriae infection, a statistically significant increase in SP and GAL concentration was shown in the lymph nodes. (agriculturejournals.cz)
In pigs, seven Brachyspira spp. (pacb.com)
Growing and finishing pigs are affected by pathogenic spirochetes of the genus Brachyspira sp. (bvsalud.org)
The objectives of this study were to characterize Brachyspira hyodysenteriae isolates and to evaluate the antimicrobial susceptibility patterns of strains obtained from pigs in Brazil based on the minimal inhibitory concentration test (MIC). (bvsalud.org)
Sera from these mice and pigs recognised the 30 kDa lipoprotein in outer membrane preparations of B. hyodysenteriae, indicating the immunogenicity of recombinant BmpB. (edu.au)
Sera from pigs naturally infected with B. hyodysenteriae also reacted with recombinant BmpB expressed in E. coli. (edu.au)
Phylogenetic diversity, antimicrobial susceptibility and virulence gene profiles of Brachyspira hyodysenteriae isolates from pigs in Germany. (uni-giessen.de)
Brachyspira intermedia which is commonly found in poultry and its significance in pigs remains unclear. (thepigsite.com)
There have also been recent reports of an emergence of two newly described also strongly haemolytic pathogenic species, Brachyspira suanatina and Brachyspira hampsonii both of which appear to have reservoirs of infection in migratory water birds, and which may be transmitted to and between pigs. (thepigsite.com)
studies have shown that even when given large doses of B. hyodysenteriae experimentally, pigs fed on cooked white rice show few clinical signs and that diets with a high digestibility in the small intestine e.g. meal, produce less solid matter passed through undigested into the large intestine for the bacteria to thrive on and so less damage occurs. (thepigsite.com)
This distinction was made as isolates from pigs exhibiting diarrhea differed from Treponema hyodysenteriae, the presumed pathogen, in both their gross and microscopic morphology and their pathological presentation. (wikipedia.org)
While isolation of 'B. hampsonii' from pigs with mucohaemorrhagic colitis is not uncommon in diagnostic cases received at the ISU VDL, B. hyodysenteriae is still the predominant species recovered from such submissions. (thepigsite.com)
Additionally, and in contrast to what has been observed in the United States, 'B. hampsonii' isolation from pigs with loose, bloody or mucoid diarrhoea has been reported at an approximately three-fold higher frequency than that observed for B. hyodysenteriae . (thepigsite.com)
A larger study followed in 2011 where groups of pigs were inoculated with one of eight different clinical isolates of Brachyspira originating from different US herds and including several weakly β-haemolytic species, typical strongly β-haemolytic B. hyodysenteriae and multiple strongly β-haemolytic isolates identified as either Brachyspira intermedia or 'Brachyspira sp. (thepigsite.com)
The study had a three-factorial design, with eight groups of pigs receiving Diet I or Diet 2, +/- B. hyodysenteriae, and +/- T suis. (dtu.dk)
Pigs on Diet I and challenged with both pathogens showed clinical symptoms of SD for a longer period than pigs inoculated with B. hyodysenteriae only. (dtu.dk)
Investigation of the impact of increased dietary insoluble fiber through the feeding of distillers dried grains with solubles (DDGS) on the incidence and severity of Brachyspira -associated colitis in pigs. (iastate.edu)
hyodysenteriae in colon of pigs when they are fed fructan-rich diets. (dtu.dk)
Ten conventional pigs (~23 kg) were orally inoculated with Brachyspira hyodysenteriae B204 T . Eight animals developed muco-haemorrhagic diarrhoea with impaired general body condition. (biomedcentral.com)

Macrolide antibiotic resistance is widespread among Brachyspira hyodysenteriae (formerly Serpulina hyodysenteriae) isolates. (nih.gov)
A gene encoding a 30 kDa outer envelope protein of the intestinal spirochaete Brachyspira (Serpulina) hyodysenteriae, was cloned and expressed in Escherichia coli strain XLOLR. (edu.au)
It was first identified in the late 1960s and previously known as Treponema hyodysenteriae and Serpulina hyodysenteriae . (thepigsite.com)
The disease is caused by a variety of spirochaete bacteria, now called Brachyspira (formerly known as Serpulina, Treponema and even Vibrio). (thepoultrysite.com)
1984 ) had been described before the genus Serpulina was created ( Stanton, 1982 ), it was considered that the four species of intestinal spirochaetes were sufficiently closely related to warrant them being included in a single genus, and the genus name Brachyspira had chronological priority over Serpulina . (cabi.org)

Retrospective analysis of partial nox gene sequences from the majority of these atypical and untypable isolates reveals they are identical or nearly identical over the region compared to either clade I or clade II isolates of the recently proposed novel species 'Brachyspira hampsonii' 2). (thepigsite.com)
Comparison of culture, PCR, and fluorescent in situ hybridization for detection of Brachyspira hyodysenteriae and " Brachyspira hampsonii " in pig feces. (iastate.edu)

A major mechanism for oxygen metabolism by B. hyodysenteriae and other Brachyspira species is NADH oxidase, based on the high specific activities of the enzyme in soluble (membrane-free) cell fractions of the spirochetes ( 40 , 43 ). (asm.org)
Further development of IMS techniques is required to improve isolation rates of Brachyspira species from faecal samples. (microbiologyresearch.org)
Additionally, multiple Brachyspira species have been increasingly isolated by North American diagnostic laboratories. (asm.org)
In general, Brachyspira species showed high susceptibility to tiamulin, valnemulin, and carbadox, heterogeneous susceptibility to doxycycline, and low susceptibility to lincomycin and tylosin. (asm.org)
Finally, this study also highlights the urgent need for Clinical and Laboratory Standards Institute-approved clinical breakpoints for Brachyspira species, to facilitate informed therapeutic and control strategies. (asm.org)
Isolation and antimicrobial susceptibility of Brachyspira species from feces of layer chickens in Germany. (uni-giessen.de)
What is the most important species of Brachyspira? (brainscape.com)
What species of Brachyspira causes avian intestial spirochaetosis? (brainscape.com)
VSH-1-like agents appear to be widely distributed among Brachyspira species and, as demonstrated for B. hyodysenteriae, may serve as useful gene transfer agents. (usda.gov)
Brachyspira murdochii which was thought to be commensal (normal inhabitant) to the intestine but is now considered to be a low-pathogenic species that interestingly has also been isolated from chickens and rodents - who infects who remains unclear. (thepigsite.com)
Because of this, to accurately determine species-level identification of Brachyspira species, genetic sequencing should be considered (i.e. (wikipedia.org)
It is, therefore, an important part of diagnosis to differentiate the species of Brachyspira that is involved. (thepoultrysite.com)
Multiple pooled-faeces samples were taken from each farm to try to increase the chances of diagnosis as Brachyspira are difficult to culture and to differentiate the species requires additional culture and biochemical tests. (thepoultrysite.com)
Little work has been done on the pathogenic effect of these various spirochaetes but a study was reported where different Brachyspira species were given to day old chicks to see if they would colonise the gut and would have a depressive effect on chick growth (see Fig. 2). (thepoultrysite.com)
Brachyspira species isolated from UK layer samples. (thepoultrysite.com)
The multiplex qPCR with a limit of detection of 5-10 genomic equivalents (GE) per reaction (6 × 102 GE per gram) allows reliable detection of Brachyspira species directly from fecal swab DNA. (uzh.ch)
This phylum contains many medically important bacteria including Treponema pallidum (syphilis), several Borrelia species (relapsing fever), Borrelia burgdorferi (Lyme disease), Leptospira interrogans (leptospirosis), Brachyspira sp. (pnas.org)
UK - The term avian intestinal spirochaetosis (AIS) refers to disease in chickens and sometimes other avian species associated with the presence of Brachyspira species spirochaetes in the large intestine, according to the Animal Health and Veterinary Laboratories Agency in their Veterinary Information Note . (thepoultrysite.com)
Brachyspira species are primarily detected in the caeca, and persistent caecal colonisation can occur. (thepoultrysite.com)
B. hyodysenteriae is the most pathogenic of all spiral-shaped, haemolytic Brachyspira species with an anaerobe metabolism. (huvepharma.com)

The nucleotide sequences of the peptidyl transferase region of the 23S rDNA from seven macrolide and lincosamide resistant and seven susceptible strains of Brachyspira spp. (nih.gov)
The resulting plasmids, respectively, pCmΔNOX and pKmΔNOX, were used to transform wild-type B. hyodysenteriae B204 cells and generate the antibiotic-resistant strains Nox-Cm and Nox-Km. (asm.org)
Multilocus sequence typing (MLST) and Multiple Locus Variable number tandem repeat Analysis (MLVA) were used to characterize B. hyodysenteriae strains isolated from trucks. (biomedcentral.com)
This result confirmed that MLST and MLVA can support the study of epidemiological links between different B. hyodysenteriae farm strains. (biomedcentral.com)
Virulence of strong and weakly haemolytic strains of Brachyspira hyodysenteriae - Descarga este documento en PDF. (duhnnae.com)
Alternative disease control strategies (for example, vaccines) will benefit from, if not require, tools and techniques for genetically attenuating virulent strains of B. hyodysenteriae. (usda.gov)
The amplicon was used as a probe in Southern blot hybridizations to detect homologous svp38 genes in the digested genomic DNA's of 27 Brachyspira strains. (usda.gov)
Subclinical colitis associated with moderately hemolytic Brachyspira strains. (aasv.org)
SmpB: a novel outer membrane protein present in some Brachyspira hyodysenteriae strains. (biomedsearch.com)
It is only in recent years we have been able to differentiate between the strains of Brachyspira, which can be found in the chicken's intestine following excellent work by David Hampson's group in Murdoch University, Western Australia. (thepoultrysite.com)

It can be evidenced by the occurrence of Brachyspira s p. in laying farms and hens in Brazil, with special relevance to Brachyspira intermedia that can be potentially pathogenic for these animals. (scielo.br)

Furthermore, reduced susceptibility of B. hyodysenteriae to antimicrobials is of increasing concern. (pacb.com)

Genetic evidence, including targeted mutagenesis studies in Treponema denticola and Brachyspira hyodysenteriae , have shown that these organelles are directly involved in motility ( 9 , 10 ) (C. Li and N.W.C., unpublished observations). (pnas.org)

These results provide evidence that NADH oxidase serves to protect B. hyodysenteriae cells against oxygen toxicity and that the enzyme, in that role, contributes to the pathogenic ability of the spirochete. (asm.org)
The enzyme may be important in early stages of the disease when cells first populate mucosal tissues or in later stages when oxygen-carrying erythrocytes enter the spirochete habitat and are possibly lysed by the B. hyodysenteriae hemolysin. (asm.org)
The essential causal agent is Brachyspira hyodysenteriae , an anaerobic spirochete that produces a hemolysin, although other organisms may contribute to the severity of lesions. (merckvetmanual.com)

Bacteria of the genus Brachyspira can cause enteric diseases in poultry causing a decrease in productivity. (scielo.br)
The objective of this study was to evaluate the presence of bacteria of the genus Brachyspira sp. (scielo.br)
What virulence factor is necessary for Brachyspira and allows the bacteria to move through intestinal mucosa? (brainscape.com)
Brachyspira is a genus of bacteria classified within the phylum Spirochaetes. (wikipedia.org)
permanent intracellular host = mitochondrion Brachyspira bacteria have evolved a parasitic lifestyle through genomic reduction (~2.5 to 3.3 Mb) compared to other gram negative bacteria (~5 Mb). (wikipedia.org)
Once attached apically to the enterocyte, hidden to the natural and acquired immunity by the mucous layer and occupying a niche that other bacteria cannot use, Brachyspira most likely expresses at its apex porins [3] allowing it to import from the colonocyte's cytoplasm the amino acids and nucleic acids necessary to replicate. (wikipedia.org)

Additionally, since the latter part of 2008, there has been a concurrent increase in the number of cases with diarrhoea and lesions suggestive of SD from which a strongly β-haemolytic spirochaete was isolated that was not identified as B. hyodysenteriae by available laboratory methods (Figure 1). (thepigsite.com)
Easily recognisable symptoms of a B. hyodysenteriae infection are a bloody, mucoid diarrhoea together with a different consistency and colour of the faeces. (huvepharma.com)

Brachyspira murdochii appeared to be a relatively poor coloniser, which may account for its infrequent isolation in the field but it and B. hyodysenteriae could be potentially pathogenic in chickens. (thepoultrysite.com)

Except for Brachyspira hyodysenteriae , the clinical significance of these in vitro activities is unknown. (drugs.com)
What is the major clinical sign of Brachyspira? (brainscape.com)
Diagnosis in a large breeding and/or grower-finisher unit will be based upon on the history of how the disease has spread and for how long, the clinical signs, post-mortem examinations, laboratory tests on faecal smears and the isolation and identification of B. hyodysenteriae by serological or biochemical tests and DNA analysis. (thepigsite.com)
While no Clinical and Laboratory Standards Institute (CLSI) antimicrobial breakpoints for Brachyspira have been established, resistance to the pleuromodulins tiamulin and valnemulin is considered at MIC ≥ 2 µg/ml. (wikipedia.org)
The results of this pilot study revealed that these strongly β-haemolytic isolates were indeed pathogenic and produced clinical disease resembling SD associated with typical B. hyodysenteriae infection (4). (thepigsite.com)
In Canada, Harding and others (2011) have reported on outbreaks of clinical disease in finishing sheds with B. hyodysenteriae but also with a potential new strain of Brachyspira sp. (pigprogress.net)
The diagnosis is based on the detection of the Brachyspira organisms is association with clinical signs of disease. (thepoultrysite.com)

Several virulence factors are described for B. hyodysenteriae . (pigprogress.net)
The pathogenicity of B. hyodysenteriae depends on the virulence factors of the strain. (huvepharma.com)

Mice are an important reservoir of infection for B hyodysenteriae , and any eradication attempt must include elimination/reduction of the mouse population on the farm. (merckvetmanual.com)
In vitro, colonic mucus-producing mucosal surfaces were treated with these factors along with B. hyodysenteriae infection and analyzed for their effect on mucin production. (gu.se)
Therefore, we suggest that the SPDEF, FOXA3, and MAPK3/ERK1 signaling pathways are behind the transcriptional program regulating mucin biosynthesis in the colon during B. hyodysenteriae infection. (gu.se)
Natural infection of chickens with B.hyodysenteriae is rarely reported, but this organism can cause severe ulcerative typhlitis in the rhea. (thepoultrysite.com)
Efforts should be made to minimise the impact of diet and other infectious and non-infectious factors which may underlie Brachyspira infection. (thepoultrysite.com)
Brachyspira hyodysenteriae Infection Regulates Mucin Glycosylation Synthesis Inducing an Increased Expression of Core-2 O-Glycans in Porcine Colon. (readbyqxmd.com)
Infection with this pathogen results in an increase in B. hyodysenteriae binding sites on mucins, along with increased colonic mucin secretion. (readbyqxmd.com)

Crows may contribute in the spread of Brachyspira hyodysenteriae. (pigprogress.net)

The disease's aetiological agent is Brachyspira hyodysenteriae , a gram-negative anaerobic bacterium capable of damaging the enterocytes of the large intestine and causing severe mucohaemorragic enteric disease. (biomedcentral.com)
The Brachyspira proliferate in the large intestine and causes degeneration and inflammation of the superficial mucosa, hypersecretion of mucus by mucosal epithelium, and multifocal bleeding points on the mucosal surface. (merckvetmanual.com)
Confirmation is based on demonstration of typical histologic lesions in the large intestine and isolation of strongly β-hemolytic Brachyspira by anaerobic culture. (merckvetmanual.com)

Animals are infected after an oral intake of Brachyspira pathogens from a contaminated environment or infected vectors. (pigprogress.net)

Details of the four previously sequenced weakly haemolytic B. hyodysenteriae are included for comparison. (biomedcentral.com)
Green line: Weakly Β-haemolytic Brachyspira spp. (thepigsite.com)
Black line: strongly Β-haemolytic, not identified as B. hyodysenteriae by PCR. (thepigsite.com)
Following the identification of several untypable strongly β-haemolytic Brachyspira spp. (thepigsite.com)

For the most part, bacterial characteristics essential for B. hyodysenteriae colonization and pathogenesis have not been thoroughly investigated, although there is evidence that hemolytic activity ( 15 , 48 ) and bacterial motility and chemotaxis ( 18 , 26 , 32 ) are important contributing factors. (asm.org)
One of the genes for this virus was detected in bacterial groups that are related to B. hyodysenteriae. (usda.gov)
For the 50 years that followed, the root of the disease was unknown until researchers discovered it is caused by the bacterial agent Brachyspira hyodysenteriae. (kemin.com)

Culture B. hyodysenteriae from mucosa or feces. (iastate.edu)
Brachyspira hyodysenteriae can occasionally be isolated from feces (swabs are even less reliable). (iastate.edu)

Publications now tend to point out that Brachyspira colonization should not be considered harmless commensalism: Chronic diarrhea Irritable bowel syndrome Acute intestinal pain Ulcerative colitis Post translocation spirochetemia and cardiogenic shock Treament with 10 days co-amoxicilline 1g bid + metronidazole 500 tid seems to have very good results on abdominal symptoms. (wikipedia.org)

Brachyspira innocens which is considered non-pathogenic. (thepigsite.com)

Brachyspira contains Hemolysin. (brainscape.com)

We predict that B. hyodysenteriae modifies the glycosylation pattern of the porcine intestinal mucus layer to optimize its host niche. (readbyqxmd.com)

The MIC was performed for 22 B. hyodysenteriae isolates obtained from 2011 to 2013 using the following antimicrobial drugs tylosin , tiamulin, valnemulin, doxycycline , lincomycin and tylvalosin. (bvsalud.org)

Brachyspira hyodysenteriae colonizes the pig colon, resulting in mucoid hemorrhagic diarrhea and mucus layer changes. (gu.se)

what is the pathogenesis for Brachyspira? (brainscape.com)

In general, Brachyspira isolates from the United States were more susceptible to these antimicrobials than were isolates from other countries. (asm.org)

The gene for the B. hyodysenteriae NADH oxidase has been cloned ( 47 ). (asm.org)
All of the samples subjected to phylogenetic analysis based on the nox gene sequence exhibited similar results, showing 100% identity to B. hyodysenteriae. (bvsalud.org)
Todas as amostras submetidas à análise filogenética com base na sequência do gene nox exibiram resultados semelhantes, indicando 100% de identidade com B. hyodysenteriae. (bvsalud.org)
In these studies, one genetic tool, VSH-1, a bacteriophage virus that transfers genes between B. hyodysenteriae cells, was characterized at the gene level. (usda.gov)
VSH-1 is the first recognized mechanism for gene transfer between B. hyodysenteriae cells. (usda.gov)
A 343-bp region of gene svp38, encoding the VSH-1 major head protein, was amplified from B. hyodysenteriae genomic DNA by PCR. (usda.gov)
The VSH-1 svp- 38 gene was associated with a 40 kb SalI-SmaI fragment of the B. hyodysenteriae B78**T chromosome, indicating VSH-1 DNA insertion into the chromosome at a unique site. (usda.gov)

Sixty-one of 976 and 4 of 763 environmental swabs collected from trucks before and after cleaning and disinfection operations, respectively, were positive for B. hyodysenteriae . (biomedcentral.com)

The purified NADH oxidase of B. hyodysenteriae B204 is a flavin adenine dinucleotide-dependent, monomeric protein with an apparent molecular mass, based on gel migration, of 47 to 48 kDa ( 45 ). (asm.org)
To increase solubility and stability of 5BT, it was conjugated with BmpB, the membrane protein B of Brachyspira hyodysenteriae (B5BT). (biomedcentral.com)

The genetic basis of macrolide and lincosamide resistance in B. hyodysenteriae was elucidated. (nih.gov)

No antimicrobials are specifically licensed for the control of Brachyspira in poultry, but several products are routinely used under the cascade. (thepoultrysite.com)

The aim of the present study was to estimate test accuracies of a PCR originally designed for use as a confirmatory test, displaying a high diagnostic specificity, and cultural examination for B. hyodysenteriae. (uzh.ch)
Since then, increasing numbers of Brachyspira isolations have been reported by veterinary diagnostic laboratories in the United States ( 9 ). (asm.org)
Multiplex qPCRs are promising diagnostic tools, as Brachyspira do not grow on conventional media. (wikipedia.org)

B. hyodysenteriae is an aerotolerant anaerobe. (asm.org)

There is a lot on new interest in Brachyspira spp, which has almost been left behind microbiologically but its whole genome has now been sequenced and further advances will be made both on its pathogenicity and hopefully diagnosis. (pigprogress.net)

What are the most important reservoir for Brachyspira hyodysenteriae? (brainscape.com)
Finally, also rodents constitute a reservoir of Brachyspira . (pigprogress.net)

The epidemiology of B. hyodysenteriae infections is only partially understood, but different methods for detection, identification and typing have supported recent improvements in knowledge and understanding. (pacb.com)
Infections with Brachyspira hyodysenteriae have a significant negative impact on several technical parameters such as daily growth, feed conversion and mortality rate and result in increasing treatment costs. (huvepharma.com)

It is interesting to consider that Brachyspira could be the missing link between independent gram-negatives and eventually internalized organisms like Mitochondria. (wikipedia.org)
Brachyspira organisms are strict anaerobes and samples should be kept as anaerobic as possible. (thepoultrysite.com)

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Analysis of Serpulina hyodysenteriae strain variation and its molecular epidemiology using pulsed-field gel electrophoresis. (1/81)

A comparison of the morphologic effects of Serpulina hyodysenteriae or its beta-hemolysin on the murine cecal mucosa. (2/81)

Isolation, oxygen sensitivity, and virulence of NADH oxidase mutants of the anaerobic spirochete Brachyspira (Serpulina) hyodysenteriae, etiologic agent of swine dysentery. (3/81)

Characterization of a periplasmic ATP-binding cassette iron import system of Brachyspira (Serpulina) hyodysenteriae. (4/81)

Changes in bacterial community structure in the colon of pigs fed different experimental diets and after infection with Brachyspira hyodysenteriae. (5/81)

The spirochete FlaA periplasmic flagellar sheath protein impacts flagellar helicity. (6/81)

Antigen-specific proliferation of porcine CD8alphaalpha cells to an extracellular bacterial pathogen. (7/81)

Cloning of a beta-hemolysin gene of Brachyspira (Serpulina) hyodysenteriae and its expression in Escherichia coli. (8/81)

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Analysis of Serpulina hyodysenteriae strain variation and its molecular epidemiology using pulsed-field gel electrophoresis. (1/81)

A comparison of the morphologic effects of Serpulina hyodysenteriae or its beta-hemolysin on the murine cecal mucosa. (2/81)

Isolation, oxygen sensitivity, and virulence of NADH oxidase mutants of the anaerobic spirochete Brachyspira (Serpulina) hyodysenteriae, etiologic agent of swine dysentery. (3/81)

Characterization of a periplasmic ATP-binding cassette iron import system of Brachyspira (Serpulina) hyodysenteriae. (4/81)

Changes in bacterial community structure in the colon of pigs fed different experimental diets and after infection with Brachyspira hyodysenteriae. (5/81)

The spirochete FlaA periplasmic flagellar sheath protein impacts flagellar helicity. (6/81)

Antigen-specific proliferation of porcine CD8alphaalpha cells to an extracellular bacterial pathogen. (7/81)

Cloning of a beta-hemolysin gene of Brachyspira (Serpulina) hyodysenteriae and its expression in Escherichia coli. (8/81)

Virulent Serpulina hyodysenteriae from a pig in a herd free of clinical swine dysentery - Murdoch Research Repository

Estimating diagnostic test accuracies for brachyspira hyodysenteriae accounting for the complexities of population structure in...

Brachyspira hyodysenteriae 1- (5-phosphoribosyl) -5-[ (5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide...

probeBase 2016 | An online resource for rRNA-targeted oligonucleotides

Most recent papers with the keyword Mlst | Read by QxMD

AID 205190 - In vitro antibacterial activity against Serpulina (Treponema) hyodysenteriae was tested and is expressed as...

Pre GI: BLASTP Hits

Combating Antibiotic Resistance in Veterinary Medicine and Animal Production with Antibiotic Substitutes (Part 3) | The...

Valnemulin Hydrochloride | Bacterial Inhibitor | MedChemExpress

The effect of fermentable carbohydrates on experimental swine dysentery and whip worm infections in pigs - DTU Orbit

KEGG PATHWAY: Methane metabolism - Brachyspira hyodysenteriae WA1

Genetic relatedness amongst intestinal spirochaetes isolated from rats and birds - Murdoch Research Repository

Efficacy of virginiamycin as a prophylactic drug to prevent swine dysentery

Farmers urged to sign up to disease charter following recent Swine Dysentery cases

Friendship RM. Gastric ulceration in swine

Porcine Epidemic Diarrhea (PED) | Iowa State University

Porcine Epidemic Diarrhea (PED) | Iowa State University

Blood concentrations of the cytokines IL-1beta, IL-6, IL-10, TNF-alpha and IFN-gamma during experimentally induced swine...

Another case of Swine Dysentery detected in Yorkshire

PigProgress - Swine dysentery today (Special 2005)

Suffolk swine dysentery outbreak demands vigilance - Farmers Weekly

Swine Dysentery - Digestive System - Merck Veterinary Manual

Immunomagnetic separation of the intestinal spirochaetes Brachyspira pilosicoli and Brachyspira hyodysenteriae from porcine...