Zinc Compounds: Inorganic compounds that contain zinc as an integral part of the molecule.Xylariales: An order of ascomycetous FUNGI which includes many economically important plant parasites as well as saprophytes.Zinc: A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Zinc Fingers: Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.Zinc Sulfate: A compound given in the treatment of conditions associated with zinc deficiency such as acrodermatitis enteropathica. Externally, zinc sulfate is used as an astringent in lotions and eye drops. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.Medicine, Ayurvedic: The traditional Hindu system of medicine which is based on customs, beliefs, and practices of the Hindu culture. Ayurveda means "the science of Life": veda - science, ayur - life.Soybeans: An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.Medicine, Chinese Traditional: A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.China: A country spanning from central Asia to the Pacific Ocean.Drugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.Hydrology: Science dealing with the properties, distribution, and circulation of water on and below the earth's surface, and atmosphere.Fertility: The capacity to conceive or to induce conception. It may refer to either the male or female.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Minerals: Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Trace Elements: A group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)EncyclopediasBone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Wound Healing: Restoration of integrity to traumatized tissue.Fingers: Four or five slender jointed digits in humans and primates, attached to each HAND.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Dietary Supplements: Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.Vitamins: Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.Lactose Intolerance: The condition resulting from the absence or deficiency of LACTASE in the MUCOSA cells of the GASTROINTESTINAL TRACT, and the inability to break down LACTOSE in milk for ABSORPTION. Bacterial fermentation of the unabsorbed lactose leads to symptoms that range from a mild indigestion (DYSPEPSIA) to severe DIARRHEA. Lactose intolerance may be an inborn error or acquired.Vitamin B Complex: A group of water-soluble vitamins, some of which are COENZYMES.Diet: Regular course of eating and drinking adopted by a person or animal.Halitosis: An offensive, foul breath odor resulting from a variety of causes such as poor oral hygiene, dental or oral infections, or the ingestion of certain foods.Science: The study of natural phenomena by observation, measurement, and experimentation.Sulfur Compounds: Inorganic or organic compounds that contain sulfur as an integral part of the molecule.Breath Tests: Any tests done on exhaled air.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Mouth: The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.African Americans: Persons living in the United States having origins in any of the black groups of Africa.Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.Infertility, Male: The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.Cystinyl Aminopeptidase: A zinc-containing sialoglycoprotein that is used to study aminopeptidase activity in the pathogenesis of hypertension. EC 3.4.11.3.Aminopeptidases: A subclass of EXOPEPTIDASES that act on the free N terminus end of a polypeptide liberating a single amino acid residue. EC 3.4.11.Glucose Transporter Type 4: A glucose transport protein found in mature MUSCLE CELLS and ADIPOCYTES. It promotes transport of glucose from the BLOOD into target TISSUES. The inactive form of the protein is localized in CYTOPLASMIC VESICLES. In response to INSULIN, it is translocated to the PLASMA MEMBRANE where it facilitates glucose uptake.Nootropic Agents: Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.Glutamyl Aminopeptidase: A ZINC-dependent membrane-bound aminopeptidase that catalyzes the N-terminal peptide cleavage of GLUTAMATE (and to a lesser extent ASPARTATE). The enzyme appears to play a role in the catabolic pathway of the RENIN-ANGIOTENSIN SYSTEM.Angiotensin II: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.Leucyl Aminopeptidase: A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.Epithelial-Mesenchymal Transition: Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition.Extracellular Matrix: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.Matrix Metalloproteinases: A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Mesoderm: The middle germ layer of an embryo derived from three paired mesenchymal aggregates along the neural tube.Cadherins: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Matrix Metalloproteinase 2: A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.
Zinc compounds, more specifically zinc ascorbate, also play a role in preventing plaque accumulation due to antimicrobial ... Zinc salts inhibit bacterial growth by binding to sulfur to control plaque formation, as well as reduce foul oral odours. ... are able to bind directly to the enamel as well as the mineralized sections of the teeth where it takes up the binding sites ... These compounds are able to work on the whole mouth including between teeth and all the way up to the gum line, and is not ...
... (C2H5)2Zn, or DEZ, is a highly pyrophoric organozinc compound consisting of a zinc center bound to two ethyl groups ... Edward Frankland first reported the compound in 1848 from zinc and ethyl iodide, the first organozinc compound discovered. He ... 1 mixture of ethyl iodide and ethyl bromide with a zinc-copper couple, a source of reactive zinc. The compound crystallizes in ... E. Frankland, B. F. Duppa (1864). "On a new reaction for the production of the zinc-compounds of the alkyl-radical". Journal of ...
NV038, like other zinc ejector compounds, chelates zinc to remove it from its binding site. However, it is thought to act ... It ejects the zinc from the zinc binding sites in a two steps. The zinc in the carboxyl-terminal zinc finger is released first ... that make up the zinc (II) ion binding sites. The binding of zinc (II) in the CCHC binding site is necessary for the domain to ... Zinc finger inhibitors, or zinc ejectors, are substances or compounds that interact adversely with zinc fingers and cause them ...
Many compounds in the thiol zinc-binding groups have good water solubility and are air stable in plasma and these groups will ... Jacobsen, J. A.; Major Jourden, J. L.; Miller, M. T.; Cohen, S. M. (2010). "To bind zinc or not to bind zinc: An examination of ... MMI-166 has an N-arylsulfonyl-α-aminocarboxylate zinc-binding group, different from the hydroxamate-zinc binding group seen in ... Carbamoyl phosphonate zinc binding groups binds Zn2+ through the oxygen of the phosphonate and the oxygen of the alpha carbonyl ...
The zinc finger motif is a rigid substructure in a protein which facilitates the binding of the protein to another molecule ... Other binary compounds of zinc include zinc peroxide ZnO 2, zinc hydride ZnH 2, and zinc carbide ZnC 2. Zinc nitrate Zn(NO 3) 2 ... Cadmium zinc telluride Mercury cadmium telluride Zinc gluconate Zinc pyrithione Zinc ricinoleate Zinc stearate Zinc pest ... zinc molybdate ZnMoO 4 (used as white pigment), zinc chromate ZnCrO 4 (one of the few colored zinc compounds), zinc arsenite Zn ...
... is an inorganic compound with the formula ZnO. ZnO is a white powder that is insoluble in water, and it is widely ... For material science applications, zinc oxide has high refractive index, high thermal conductivity, binding, antibacterial and ... Zinc oxide itself is non-toxic; however it is hazardous to inhale zinc oxide fumes, as generated when zinc or zinc alloys are ... Zinc oxide is added to many food products, including breakfast cereals, as a source of zinc,[83] a necessary nutrient. (Zinc ...
... with the gram-positive wall providing a composition more conducive to binding. Recently the compound has found use as a mineral ... It was noted that ZnO2 was preferable to the usage of barium compounds, as it was deemed to be less toxic. The zinc compound ... Zinc peroxide can be synthesized through the reaction of zinc chloride and hydrogen peroxide. zinc hydroxide is reacted with a ... "ESR Studies on Zinc Peroxide and Zinc Oxide Obtained from a Decomposition of Zinc Peroxide". J. Phys. Chem. 75 (20): 3089-3092 ...
... which are available for binding. When zinc lacks electron donating ligands it is unable to obtain coordination saturation, ... The first such compound, decamethyldizincocene, was reported in 2004. Compounds of zinc Compounds of carbon with other elements ... Zinc-copper couple is commonly used to activate zinc. Organozinc compounds derived from methylene bromide or iodide can ... The zinc must be activated to facilitate this redox reaction. One of such activated form of zinc employed by Frankland is zinc- ...
The structure is relevant to its considerable stability (the compound is distillable at 330 °C). Basic zinc acetate - ... "Basic acetates" consist of an ensemble of metal centres bound to a central oxide ion, and a collection of acetate ligands. ... Basic beryllium acetate is the chemical compound with the formula Be4O(O2CCH3)6. Although this compound has no applications and ... The compound is a colourless solid that is soluble in organic solvents. It can be prepared by treating basic beryllium ...
... are a class of diol ligands often used to bind titanium, but have been adopted for zinc addition chemistry. These ligands ... In asymmetric addition of dialkylzinc compounds to aldehydes dialkyl zinc compounds can be used to perform asymmetric additions ... Many ligands have been developed for binding zinc during addition reactions. TADDOLs (tetraaryl-1,3-dioxolane-4,5-dimethanols ... Dimethyl zinc is often used with an asymmetric amino alcohol, amino thiol, or other ligand to affect enantioselective additions ...
... for it include: ZX1, a compound comprizing a dipicolylamine (DPA) Zinc binding subunit that has greater ... a compound containing a dichlorofluorescein fluorescent compound bound to two 2-picolamine (DPA) species that bind Zn(II). ZP1 ... Chemodosimeters, complexes that undergo irreversible reactions with other species upon binding a metal to form new compounds ... CTAP-1 is effective as it has a large modulation in its spectrum upon binding Cu, and is selective for the binding of Cu over ...
Cu3He binding energy 0.90 cm−1, O4He binding energy 5.83 cm−1, S4He binding energy 6.34 cm−1, Se4He binding energy 6.50 cm−1, ... Zinc vapour did not react with helium. J. J. Manley claimed to have found gaseous mercury helide HeHg in 1925 HgHe10; ... F4He binding energy 3.85 cm−1, Cl4He binding energy 7.48 cm−1, Br4He binding energy 7.75 cm−1, I4He binding energy 8.40 cm−1, ... N4He binding energy 2.85 cm−1, P4He binding energy 3.42 cm−1, As4He binding energy 3.49 cm−1, Bi4He binding energy 33.26 cm−1, ...
Phytic acid has a strong binding affinity to minerals such as calcium, magnesium, iron, copper, and zinc. This results in ... These compounds chelate metals such as iron and zinc and reduce the absorption of these nutrients,[19] but they also inhibit ... It binds very tightly to biotin (vitamin B7)[15] and can cause deficiency of B7 in animals[16] and, in extreme cases, in humans ... Widespread form of antinutrients are the flavonoids, which are a group of polyphenolic compounds that include tannins.[18] ...
He settled on using a sulfhydryl group which binds strongly to zinc. Ondetti had discovered Captopril, an ACE inhibitor with ... U.S. Patent 3,740,385 "N-Terminal Derivatives of Secretin", filed May 1970, issued June 1973 U.S. Patent 4,199,512 "Compounds ... He argued that using a strong chemical binder to the zinc in the enzyme would increase activity. ... "Compounds for alleviating angiotensin related hypertension", filed February 1978, issued July 1982 U.S. Patent 4,722,810 " ...
Organolithium can also be used in to prepare organozinc compounds through transmetalation with zinc salts. Llithium ... This is the most common method for preparing alkynyllithium reagents, because the terminal hydrogen bound to the sp carbon is ... In allyl lithium compounds, the lithium cation coordinates to the face of the carbon π bond in an η-3 fashion instead of a ... For aromatic compounds, the position of lithiation is also determined by the directing effect of substituent groups. Some of ...
Soil is also assessed for several micronutrients, like zinc and boron. The percentage of organic matter, soil pH, and nutrient ... Techniques include no-tilling crops, planting of soil-binding grasses along contours on steep slopes, and contour drains of ... Common macronutrients analyzed include compounds of nitrogen, phosphorus, potassium, calcium, magnesium, and sulfur. ...
This compound was first described in the 1930s. Pyrithione is the conjugate base derived from 2-mercaptopyridine-N-oxide (CAS# ... When used in latex paints with water containing high amount of iron, a sequestering agent that will preferentially bind the ... Zinc pyrithione (or pyrithione zinc) is a coordination complex of zinc. It has fungistatic (that is, it inhibits the division ... In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer (see figure), where each zinc is bonded to two ...
In porphyrin systems, the zinc ion (Zn2+) appears to hinder the photodynamic activity of the compound. By contrast, in the ... Expanded porphyrins have a larger central binding cavity, increasing the range of potential metals.[5] ... Zinc phthalocyanine[edit]. A liposomal formulation of zinc phthalocyanine (CGP55847) has undergone clinical trials (Phase I/II ... Zinc and copper cationic derivatives have been investigated. The positively charged zinc complexed PC is less photodynamically ...
Copper and zinc are known to bind to amyloid beta proteins in Alzheimer's disease. This bound form is thought to mediate the ... One study of two strains of mice fed copper compounds found a varying increased incidence of reticulum cell sarcoma in males of ... Faller P (2009-12-14). "Copper and zinc binding to amyloid-beta: coordination, dynamics, aggregation, reactivity and metal-ion ... Copper in the blood and blood stream exists in two forms: bound to ceruloplasmin (85-95%), and the rest "free", loosely bound ...
... appears to bind copper and zinc in vivo only weakly. In contrast DMPS und DMSA bind these ions more strongly. Its ... The U.S. FDA in April 2012 also designated the compound as an orphan drug Like most thiols, BDTH2 binds to mercury salts to ... BDTH2 appears to bind mercury more strongly than do other chelators. The mercury-BDT complex does not break down even at high ... The compound was reported in about 1994 after a search for chelating agents selective for mercury. It was licensed in 2006 to ...
The acyl group of the carboxyalkanoyl amino acid binds the zinc ion of the enzyme and occupies the same position at the active ... zinc chelating group. Silicone forms a dialkylsilanediol compound that is sufficiently hindered so the formation of a siloxane ... Then the search for a better zinc-binding group started. Replacement of the succinyl carboxyl group by nitrogen-containing ... a group with greater affinity for the enzyme bound zinc ion. This yielded a potent inhibitor that was 1000 times more potent ...
The parent compound (with the organic substituent replaced by hydrogen) is the hypothetical compound sulfurous acid. Salts or ... Sulfonic acids tend to bind tightly to proteins and carbohydrates. Most "washable" dyes are sulfonic acids (or have the ... Methanesulfonic acid is used as the supporting electrolyte of the zinc-cerium and lead-acid (methanesulfonate) flow batteries. ... A sulfonic acid (or sulphonic acid) refers to a member of the class of organosulfur compounds with the general formula R−S(=O)2 ...
The human dopamine transporter (hDAT) contains a high affinity extracellular zinc binding site which, upon zinc binding, ... Amphetamine and its derivatives like methamphetamine are weak base compounds that are the only widely used class of drugs known ... do not contain zinc binding sites. Zinc supplementation may reduce the minimum effective dose of amphetamine when it is used ... Zinc binds at ... extracellular sites of the DAT [103], serving as a DAT inhibitor. In this context, controlled double-blind ...
The human dopamine transporter contains a high affinity extracellular zinc binding site which, upon zinc binding, inhibits ... "Compound Summary". p-Hydroxyamphetamine. PubChem Compound. United States National Library of Medicine - National Center for ... Zinc binds at ... extracellular sites of the DAT [103], serving as a DAT inhibitor. In this context, controlled double-blind ... With regard to zinc supplementation, a placebo controlled trial reported that doses up to 30 mg/day of zinc were safe for at ...
The human dopamine transporter contains a high affinity extracellular zinc binding site which, upon zinc binding, inhibits ... "Compound Summary". p-Hydroxyamphetamine. PubChem Compound. United States National Library of Medicine - National Center for ... Zinc binds at ... extracellular sites of the DAT [103], serving as a DAT inhibitor. In this context, controlled double-blind ... The human serotonin transporter and norepinephrine transporter do not contain zinc binding sites. 4-Hydroxyamphetamine has been ...
Kornhuber J., Herr B., Thome J., Riederer P. (1995). "The antiparkinsonian drug budipine binds to NMDA and sigma receptors in ... Tert-butyl compounds. *Benzhydryl compounds. *Nervous system drug stubs. Hidden categories: *CS1 maint: multiple names: authors ...
The paper focuses on the relationship between binding affinities/inhibition capacity and the structures of the ligands that ... These two insights allowed the elegant and very rapid discovery of the zinc-binding thiol compound captopril, which entered the ... This compound has a binding affinity for hippocampus membranes that is 40 times lower than that of compound 2. A ligand ... The quinoline compounds HFI-435 and HFI-437 cannot adopt the same binding mode as the pyridinyl compound HFI-419 for steric ...
These compounds bind minerals like zinc, calcium, magnesium, iron, copper etc and make them unavailable for absorption. But ... These beans also contain other chemical compounds which mimic our body hormones and cause hormonal imbalance. Here is a list of ... Hence consumption of soybean can cause deficiency of minerals like zinc, iron and calcium which are needed for healthy sperm ... these compounds can be eliminated by few processing techniques like soaking, boiling, sprouting etc. But phytates present in ...
Metallic zinc has the greatest hemolytic effect and largest hemoglobin binding capacity; it is followed by ZnO and ZnS. It is ... Hemolysis and hemoglobinadsorption of zinc compounds. Summary. The effect of Zn, ZnO and ZnS dusts was investigated in cell ... Cadweller, D. E., Husa, W. J.: The effect of zinc-acetate on red corpuscles. J. Amer. pharm. Ass.47, 703-705 (1958).Google ... Sastry, K. S., Viswanathan, L., Ramaiah, A., Sarma, P. S.: Studies on the binding of65Zn by equine erythrozytes in vitro. ...
Diallyl sulfied, a compound found in garlic, and zinc ameliorate the cadmium-induced testicular toxicity and inhibition of ... Additional Keywords : Sex Hormone-Binding Globulin. Problem Substances : Oral Contraceptives. Adverse Pharmacological Actions ... Zinc deficiency may be associated with androgen insufficiency and hypogonadism. May 01, 1997 Add to My Research ... Vitamin A, vitamin E, zinc and selenium deficiencies may be associated with androgen deficiency in aging men. Jul 01, 1999 Add ...
Binding ≤ 10μM SCN2A-1-E. Sodium Channel Protein Type II Alpha Subunit (cluster #1 Of 2), Eukaryotic. Eukaryotes. 300. 0.37. ... Binding ≤ 10μM SCN3A-1-E. Sodium Channel Protein Type III Alpha Subunit (cluster #1 Of 2), Eukaryotic. Eukaryotes. 300. 0.37. ... Binding ≤ 10μM SCN8A-1-E. Sodium Channel Protein Type VIII Alpha Subunit (cluster #1 Of 2), Eukaryotic. Eukaryotes. 300. 0.37. ... Binding ≤ 10μM SCN1A-1-E. Sodium Channel Protein Type I Alpha Subunit (cluster #1 Of 2), Eukaryotic. Eukaryotes. 300. 0.37. ...
Low levels of zinc are essential for maintaining good health. Exposure to large amounts of zinc can be harmful. It can cause ... Zinc has been found in at least 953 of the 1,636 National Priority List sites identified by the Environmental Protection Agency ... Exposure to high levels of zinc occurs mostly from eating food, drinking water, or breathing workplace air that is contaminated ... Common zinc compounds found at hazardous waste sites include zinc chloride, zinc oxide, zinc sulfate, and zinc sulfide. Zinc ...
Structure-based identification of C-terminal Binding Protein inhibitors from the Zinc-database compound library. Antony Gruness ... Solvent Coordinated Compounds of the Family L2CuX2, where L= 2-chloro-3-fluoropyridine and X=Cl,Br. Robert DuBois 17 (Sponsor ... Thanaphorn Suk-in 16, MA 17, BCMB 5th Year Program, "Functionalization of liner poly(ethylenimine) (PEI) as DNA-binding ... Analyzing Aggregation Properties Across A Family of Amyloid Fibril Binding Small Molecules Anh-Vy Le, 20 (sponsor: Professor ...
Zinc Description Zinc is a mineral that is essential for a healthy immune system, production of certain hormones, wound healing ... Perhaps most important is zinc oxide, or zinc white, a versatile compound with many uses. Other zinc compounds include zinc ... zinc (Zn) An element that is required by plants. It is found bound to a variety of enzymes, stabilizing them and also being ... Zinc in nutritional supplements is available as zinc gluconate, zinc oxide, zinc aspartate, zinc picolinate, zinc citrate, zinc ...
PBT2 is a metal-binding compound that binds to copper and zinc with an intermediate affinity; this is essential to its function ... Several drug hits identified in yeast models are metal-binding compounds.. Metal-binding compounds show varying activities in ... a type of compound that irreversibly binds to and removes metals from the body, but an ionophore, a type of compound that ... Copper binding to Aβ can also generate free radicals, which cause oxidative damage. When amyloid plaques sequester zinc and ...
... cells to concentrate zinc to preferentially trap zinc-binding molecules within ? cells, resulting in ?-cell-targeted compound ... Indeed, the hybrid compound preferentially accumulated within rodent and human islets in a zinc-dependent manner and increased ... Latent TGF-beta binding protein-3 (LTBP-3) requires binding to TGF-beta for secretion FEBS LETTERS Chen, Y., Dabovic, B., Annes ... Next, we asked whether appending a zinc-chelating moiety onto a ?-cell replication-inducing compound was sufficient to confer ...
The mixture not only improves the dispersion of zinc salts in the elastomeric composition but also reduces mold fouling by ... reducing the migration of zinc salts to the interfacial area of the elastomeric composition. ... Process for the preparation of a rubber having polymer bound functionality Cited By (21). * Cited by examiner, † Cited by third ... Method for improving dispersion and compatibility of zinc salts in elastomeric compounds during vulcanization Download PDF Info ...
NV038, like other zinc ejector compounds, chelates zinc to remove it from its binding site. However, it is thought to act ... It ejects the zinc from the zinc binding sites in a two steps. The zinc in the carboxyl-terminal zinc finger is released first ... that make up the zinc (II) ion binding sites. The binding of zinc (II) in the CCHC binding site is necessary for the domain to ... Zinc finger inhibitors, or zinc ejectors, are substances or compounds that interact adversely with zinc fingers and cause them ...
ZINC-A free database of commercially available compounds for virtual screening. J. Chem. Inf. Model. 45, 177-182 (2005).. ... By screening the ZINC database (38) for compounds that are structurally similar to cyanuric acid or melamine, but have stronger ... The binding affinity of 4 is ~30-fold lower than 3. Two factors contribute to the difference in binding affinity: (i) ... A) A competing H-bond pairing process shows the binding of two H-bonding acceptors A and B bound to the same nonpolar site of a ...
Mercaptoamide compounds, represented by Formulas (IA), (IB), (IIA), and (IIB): ,chemistry id=CHEM-US-00001 num=1,,img id= ... HDAC is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as a hydroxamic acid or ... The compound of claim 1 wherein R1 is R2NHC(O)NH-. 12. The compound of claim 1 wherein R1 is R2NHC(S)NH-. 13. The compound of ... 2. The compound of claim 1 wherein R1 is R2NR3C(O)-. 3. The compound of claim 2 wherein R2 is -C0-2alkyl-aryl which is ...
Calcium and iron compete for absorption; so do copper and zinc. Other food components (including oxalates, compounds in leafy ... greens) bind nutrients, making them unavailable. Such interactions are factored into the recommended intakes, which assume you ... beta carotene and zinc, slowed progression of the disease. ...
This invention relates to a method for using a zinc sensor compound to detect a disease associated with the disruption of zinc ... 4 depicts the biphasic optical response of the zinc sensor compounds towards analyte binding using zinc as an example. ... Method for Zinc Quantification Using Biphasic Zinc Sensors. The biphasic zinc-response properties of the zinc sensor compounds ... The invention also relates to a method of quantifying zinc using a zinc sensor compound. The zinc sensor compound comprises an ...
The flavouring combination is unexpectedly effective in masking the unpleasant taste or aftertaste of zinc. ... of at least a flavouring oil and lauryl alcohol for use in an orally administered formulation which contains an ionisable zinc ... Zinc oxide is also used as a binding materials in denture adhesives. Zinc chloride and zinc citrate are used as anti-odour ... zinc oxide, zinc citrate, zinc chloride, zinc acetate, zinc hydroxide, zinc fluorosilicate, zinc fluorozirconate, zinc ...
... cells to concentrate zinc to preferentially trap zinc-binding molecules within ? cells, resulting in ?-cell-targeted compound ... The zinc transporter ZnT2 imports zinc into secretory vesicles and regulates zinc export from the mammary epithelial cell. ... Indeed, the hybrid compound preferentially accumulated within rodent and human islets in a zinc-dependent manner and increased ... Next, we asked whether appending a zinc-chelating moiety onto a ?-cell replication-inducing compound was sufficient to confer ...
... go after the stink rather than the stinkers with ions of zinc or other metals that bind and neutralize sulfur compounds. ... These smelly compounds are waste products released by the millions of bacteria feasting on particles of food and tissue in our ... Sulfur compounds that easily vaporize were among the stinkiest chemicals Tonzetich identified in bad breath, especially ... He used his lab's gas chromatograph, a machine that separates a complex gaseous bouquet into its constituent compounds, to ...
... the only premium zinc supplement approved by the FDA for human nutrition. Unlike other zinc supplements, OptiZinc® will not ... It also resists binding with dietary fiber and phytate, organic compounds that inhibit zinc absorption. ... Zinc (as monomethionine)*. 20 mg 134%. Note:. L-OptiZinc brand of zinc monomethionine (U.S. Patents 4,764,633 and 5,278,329) is ... Zinc supplementation may be beneficial in these cases.. One of zincs prime uses comes in boosting the immune system. People ...
For long, the same has been thought for all types of zinc. Recent studies, however, indicate that plant phytates do not affect ... zinc that has been provided as feed supplement. ... and liberate the native zinc that was bound to these compounds ... These plants contain the same native zinc concentration as normal species - i.e. not all of the zinc is bound to phytates. ... Therefore, the use of other zinc sources, like zinc sulfate or zinc oxide, is necessary. ...
... approaches to small molecule MMP inhibitors include optimization of compounds based on an array of different zinc-binding ... To bind zinc or not to bind zinc: an examination of innovative approaches to improved metalloproteinase inhibition. Biochim ... The catalytic zinc and substrate binding cleft of the catalytic domain comprise the MMP region targeted for binding and ... These synthetic compounds typically feature a zinc-chelating group such as hydroxamate derivitized with peptidic or nonpeptidic ...
Zinc acetate supplementation: Zinc binds to sulfhydryl compounds in flatulence ultimately serving to deodorize the gas. ... Activated charcoal tablets: These tablets are not likely to be effective because the charcoal-binding sites are filled on the ...
Zinc oxide is an inorganic compound with the formula ZnO. ZnO is a white powder that is insoluble in water, and it is widely ... For material science applications, zinc oxide has high refractive index, high thermal conductivity, binding, antibacterial and ... Zinc oxide itself is non-toxic; however it is hazardous to inhale zinc oxide fumes, as generated when zinc or zinc alloys are ... Zinc oxide is added to many food products, including breakfast cereals, as a source of zinc,[83] a necessary nutrient. (Zinc ...
Zhang, Siqi (2011). Effect of zinc substitution on the structure of calcium Fluoro-Alumino-Silicate glasses and glass-ceramics. ... Bright, Lois Eleanor (2017). Ligands and complexes for non-covalent binding to G-quadruplex DNA structures. University of ... Jones, Haydn Frederick (1972). Synthesis of some starch carbamates and related compounds. University of Birmingham. Ph.D. ... Slope, Louise Nicola (2018). Selective lanthanide binding sites engineered within a De Novo designed coiled coil. University of ...
  • Other viruses such as SARS, polio, Ebola, measles, human coxsackie, Dengue, rabies, human hepatitis, human parainfluenza and human respiratory syncytical have similar zinc finger motifs and could potentially benefit from zinc finger inhibitor technology. (wikipedia.org)
  • Men may benefit from zinc for two common problems. (vitabase.com)
  • However, it's possible that people with certain genes that make them susceptible to age-related vision loss might benefit from zinc supplements. (medlineplus.gov)
  • ADA inhibits HIV by electophilically attacking the sulfur atoms of the zinc coordinated cysteine. (wikipedia.org)
  • In the same manner as ADA, the compounds interact with an 18-residue polypeptide on the N terminal zinc knuckle region of the HIV nucleocapsid protein which causes ejection of the zinc from the region by covalently modifying the cysteine residues. (wikipedia.org)
  • They react with the cysteine residues on the zinc finger of the NCp7 and cause a covalent conformation change which ejects the zinc from the zinc finger domain. (wikipedia.org)
  • Dotted lines indicate the coordination of prodomain cysteine to the catalytic zinc (gray sphere), as well as the points of covalent attachment between the catalytic domain and the prodomain, fibronectin repeats, and PEX domain. (springer.com)
  • Phenylarsine oxide (PAO), which covalently binds to vicinal protein cysteine thiol groups, induces Mt1 with a magnitude of higher potency than that of As(3+). (cdc.gov)
  • PAO affinity beads effectively pulls down the carboxyl half of MTF1 (MTF1(321-675)) by binding to a cluster of five cysteine residues near the terminus. (cdc.gov)
  • Preincubation with As(3+), Cd(2+), Co(2+), Ni(2+), Ag(+), Hg(2+), and Bi(3+) blocks pulldown of MTF1(321-675) by PAO beads in vitro and in vivo, indicating that binding of the metal inducers to the same C-terminal cysteine cluster as PAO occurs. (cdc.gov)
  • A UT Arlington professor will use a new $450,000 National Science Foundation grant to develop new chemical processes and technologies based on a better understanding of the way that metals such as gold, silver, mercury and zinc bind with organic compounds for chemical reactions. (uta.edu)
  • Dias' work will explore the interaction between six metals found in the right section of the Periodic Table of Elements' d-block and what are called pi-acid ligands, which include familiar organic compounds like carbon monoxide, ethylene, acetylene and the related olefins and alkynes. (uta.edu)
  • The single crystals of representative organic and iron complex compounds were obtained and analyzed by the X-ray diffraction analysis, indicating the distorted bipyramidal geometry around the iron core. (jove.com)
  • It is a certain group of organic compounds, when ingested into our body in excess amount, get converted into uric acid. (stylecraze.com)
  • Douglas Laboratories OptiZinc supplies zinc monomethionine, a patented organic compound which provides zinc bound to the amino acid methionine in order to increase the bioavailability of zinc. (earthturns.com)
  • Ingredients such as polyphosphate, zinc salts, and chlorhexidine have active properties to help prevent or reduce the formation of plaque and tartar. (wikipedia.org)
  • However, it is not DEZ's sensitivity to oxidation which is the key to its use as a preserving agent, but its ability to neutralise acids by forming zinc salts with them. (newscientist.com)
  • Zinc can also combine with other elements, such as these sites may be sources of exposure and exposure chlorine, oxygen, and sulfur, to form zinc to zinc may harm you. (cdc.gov)
  • Zinc can also combine with other elements, such as chlorine, oxygen, and sulfur, to form zinc compounds. (cdc.gov)
  • Nov 15, 2006· The vulcanization of rubber by sulfur is a large-scale industrial process that is only poorly understood, especially the role of zinc oxide, which is added as an activator. (steunmijnclub.nl)
  • The addition of zinc oxide (ZnO) as an activator for the sulfur vulcanization of rubbers enhances the vulcanization efficiency and vulcanizate properties and reduces the vulcanization time. (steunmijnclub.nl)
  • Most zinc ore found area, such as an industrial plant, or from a container, naturally in the environment is in the form of zinc such as a drum or bottle, it enters the environment. (cdc.gov)
  • A potentiated form of zinc oxide and a new source of copper are now available for the optimal supply of these nutrients which are essential for the animal and for the gut. (allaboutfeed.net)
  • From more than 40 samples of feed grade ZnO collected worldwide, a potentiated form of zinc oxide (HiZox) showed significant differences with other products ( Figure 2 ). (allaboutfeed.net)
  • The doses used in studies have been in the high range, requiring medical supervision, but increasing dietary zinc or taking a modest supplement in order to get the RDA amount is low risk and may prove helpful for those suffering from acne. (encyclopedia.com)
  • Like all rapidly dividing cells, immune cells depend on adequate amounts of dietary zinc. (earthturns.com)
  • Testosterone is one of the hormones that requires zinc for production. (encyclopedia.com)
  • The hormone testosterone requires zinc for its production. (vitabase.com)
  • Unlike activation of phase II genes by tBHQ, induction of Mt1 expression does not occur in the presence of EDTA, when cells are cultured in zinc-depleted medium, or in cells with reduced intracellular "free" zinc due to overexpression of ZnT1, a zinc-efflux transporter, indicating that induction requires zinc. (cdc.gov)
  • X-ray crystal studies of the carbonic anhydrase II-trithiocarbonate adduct--an inhibitor mimicking the sulfonamide and urea binding to the enzyme. (proteopedia.org)
  • This is the first demonstration that imidazole and thiazole carboxylic acid-based compounds are more efficacious MMP-2 inhibitor than their hydroxamic acid derivatives. (frontiersin.org)
  • This compound was tested on human recombinant CK2 and turned out to be an active inhibitor with an IC 50 value of 1.24 µM. (mdpi.com)
  • Additionally, we performed three sets of 100 ns MD simulations of each complex in order to understand the interaction mechanism of Mrlip1 with known inhibitor RHC80267 and the newly identified compounds such as ZINC85530919, ZINC95914464 and ZINC85530320, respectively. (bioportfolio.com)
  • The timing of its reaction has not been fully clarified, doubts remain regarding its substrate and catalytic mechanism.The crystal structure of OleP in complex with clotrimazole, an inhibitor of P450s used in therapy, was solved and the complex formation dynamics was characterized by equilibrium and kinetic binding studies and compared to ketoconazole, another azole differing for the N1-substituent.Clotrimazole coordinates the heme and occupies the active site. (chemweb.com)
  • Kinetic characterization of inhibitor binding revealed OleP to follow a simple bimolecular reaction, without detectable intermediates.Clotrimazole-bound OleP adopts an open form, held by a π-π stacking chain that fastens helices F and G and the FG loop. (chemweb.com)
  • Zinc tetrakis(N-methyl-4'-pyridyl) porphyrinato is an effective inhibitor of stimulant-induced activation of RAW 264.7 cells. (cdc.gov)
  • These motifs contain two peptide units of Cys-X2-Cys-X4-His-X4-Cys (CCHC), where the X represents a substituted amino acid, that make up the zinc (II) ion binding sites. (wikipedia.org)
  • L-OptiZinc is a patented 1:1 complex of zinc and 100% natural methionine, the amino acid that is best absorbed by the body, and serves as an antioxidant. (vitabase.com)
  • for example, carboxypeptidase, a hydrolytic enzyme important in digestion, contains a zinc ion coordinated to several amino acid residues of the protein. (britannica.com)
  • While zinc and selenium deficiencies can occur at any age, by the time you reach 60, your risk can soar as high as 40 percent. (mercola.com)
  • People who are deficient in zinc are prone to getting more frequent and longer lasting infections of various types. (encyclopedia.com)
  • People who are deficient in zinc are more susceptible to infections. (vitabase.com)
  • If so, you may be deficient in zinc. (mercola.com)
  • The developed capillary electrophoresis (CE) method was applied to evaluate the aggregation activity of divalent metal ions (zinc) on bacterial cells. (springer.com)
  • In our study, the influence of the Lactococcus lactis surface modification by zinc ions at different concentration (1, 3 and 10 mM, respectively) was determined. (springer.com)
  • Sodium phytate is known to bind easily to supplemented zinc, as it is ionisable under a large pH range. (pigprogress.net)
  • In practice, this means that sodium phytate binds to zinc in a stronger way than vegetable phytate would. (pigprogress.net)
  • Stannous fluoride is a more expensive compound than sodium fluoride (a common toothpaste ingredient) and keeps tooth enamel resistant to bacteria longer. (beautylish.com)
  • Sodium tripolyphosphates as an example, are able to bind directly to the enamel as well as the mineralized sections of the teeth where it takes up the binding sites for calcium to attach, and interacts with calcium already bonded to enamel, to prevent it being able to form crystals. (wikipedia.org)
  • Sodium Hyaluronate: A powerful moisturizing agent which is not oily, sodium hyaluronate binds moisture to the skin for long lasting hydration. (neimanmarcus.com)
  • Zinc is also a trace mineral nutrient and as preparations, acne and poison ivy preparations, and such, small amounts of zinc are needed in all antidandruff shampoos. (cdc.gov)
  • It is called an "essential trace element" because very small amounts of zinc are necessary for human health. (medlineplus.gov)
  • These beans also contain other chemical compounds which mimic our body hormones and cause hormonal imbalance. (ayurhelp.com)
  • Chemical compounds such as anti-microbial elements are added to some dental diets to directly target the oral cavity in order to prevent gingivitis. (wikipedia.org)
  • Information can be found on the chemical and physical properties of zinc in Chapter 4 and on its occurrence and fate in the environment in Chapter 6. (cdc.gov)
  • Waste streams from zinc and other metal manufacturing and zinc chemical industries, domestic waste water, and run-off from soil containing zinc can discharge zinc into waterways. (cdc.gov)
  • Zineb is the chemical compound with the formula n. (steunmijnclub.nl)
  • The Notre Dame researcher told the journal Chemical Biology that his team is working to improve the stability of the zinc (II) complexes in blood to facilitate their use in living organisms. (nd.edu)
  • Induction of metallothionein I by phenolic antioxidants requires metal-activated transcription factor 1 (MTF-1) and zinc. (cdc.gov)
  • These findings establish that phenolic antioxidants activate Mt1 transcription by a zinc-dependent mechanism that involves MTF-1 binding to MREs. (cdc.gov)
  • 5.61 In order to mimic this natural binding principle we designed the artificial hosts 1 and 2. (docme.ru)
  • Metal-activated transcription factor 1 (MTF1) mediates the induction of metallothioneins I and II by zinc and stress signals. (cdc.gov)
  • On the basis of theoretical and experimental correlations between H-bond pairings and their effects on ligand binding affinity, we demonstrate that H-bonds enhance receptor-ligand interactions when both the donor and acceptor have either significantly stronger or significantly weaker H-bonding capabilities than the hydrogen and oxygen atoms in water. (sciencemag.org)
  • Zinc compounds are used by the drug industry as ingredients in some common products, such as vitamin supplements, sun blocks, diaper rash ointments, deodorants, athlete's foot preparations, acne and poison ivy preparations, and antidandruff shampoos. (cdc.gov)
  • It is also used extensively in materials science chemistry as a zinc source in the synthesis of nanoparticles. (wikipedia.org)
  • Dias' team has already experienced noted success, publishing x-ray crystal structures that revealed new information about compounds featuring gold-ethylene and gold-carbon monoxide bonds in journals such as Angewandte Chemie-International Edition, Organometallics, and Inorganic Chemistry, which is based upon work supported by the prior National Science Foundation Grant CHE-0845321. (uta.edu)
  • Subsamples of 193 children with goitre and 151 healthy children were assessed for urinary iodine excretion, thyroid hormone profile, insulin-like growth factor-1 (IGF-1) and serum zinc. (who.int)