Bothrops
Crotalid Venoms
Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.
Snake Bites
Snake Venoms
Group II Phospholipases A2
L-Amino Acid Oxidase
Batroxobin
A proteolytic enzyme obtained from the venom of fer-de-lance (Bothrops atrox). It is used as a plasma clotting agent for fibrinogen and for the detection of fibrinogen degradation products. The presence of heparin does not interfere with the clotting test. Hemocoagulase is a mixture containing batroxobin and factor X activator. EC 3.4.21.-.
Crotalus
A genus of snakes of the family VIPERIDAE, one of the pit vipers, so-called from the pit hollowing out the maxillary bone, opening between the eye and the nostril. They are distinctively American serpents. Most of the 25 recognized species are found in the southwestern United States and northern Mexico. Several species are found as far north as Canada and east of the Mississippi, including southern Appalachia. They are named for the jointed rattle (Greek krotalon) at the tip of their tail. (Goin, Goin, and Zug: Introduction to Herpetology, 3d ed; Moore: Poisonous Snakes of the World, 1980, p335)
Viperidae
A family of snakes comprising three subfamilies: Azemiopinae (the mountain viper, the sole member of this subfamily), Viperinae (true vipers), and Crotalinae (pit vipers). They are widespread throughout the world, being found in the United States, Central and South America, Europe, Asia and Africa. Their venoms act on the blood (hemotoxic) as compared to the venom of elapids which act on the nervous system (neurotoxic). (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, pp333-36)
Phospholipases A2
Edema
Viper Venoms
Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.
Pentacyclic Triterpenes
Neurogenic Inflammation
Access to Information
Journal Impact Factor
Pinnipedia
Vesicular Exanthema of Swine
Authorship
Knowledge Bases
Alice in Wonderland Syndrome
Hawks
Melanesia
The collective name for the islands of the Pacific Ocean northeast of Australia, including NEW CALEDONIA; VANUATU; New Hebrides, Solomon Islands, Admiralty Islands, Bismarck Archipelago, FIJI, etc. Melanesia (from the Greek melas, black + nesos, island) is so called from the black color of the natives who are generally considered to be descended originally from the Negroid Papuans and the Polynesians or Malays. (From Webster's New Geographical Dictionary, 1988, p748 & Room, Brewer's Dictionary of Names, 1992, p344)
Atlantic Islands
Widely scattered islands in the Atlantic Ocean as far north as the AZORES and as far south as the South Sandwich Islands, with the greatest concentration found in the CARIBBEAN REGION. They include Annobon Island, Ascension, Canary Islands, Falkland Islands, Fernando Po (also called Isla de Bioko and Bioko), Gough Island, Madeira, Sao Tome and Principe, Saint Helena, and Tristan da Cunha.
Pyrophosphatases
Phosphoric Diester Hydrolases
Phosphodiesterase I
Chromatography, High Pressure Liquid
Creatine Kinase
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for bothrops snake bites. (1/183)
OBJECTIVE: To investigate the efficacy of the H1 antihistamine promethazine against early anaphylactic reactions to antivenom. DESIGN: Sequential randomised, double blind, placebo controlled trial. SETTING: Public hospital in a venom research institute, Sao Paulo, Brazil. PARTICIPANTS: 101 patients requiring antivenom treatment after being bitten by bothrops snakes. INTERVENTION: Intramuscular injection of promethazine (25 mg for adults and 0.5/kg for children) or placebo given 15-20 min before starting intravenous infusion of antivenom. MAIN OUTCOME MEASURES: Incidence and severity of anaphylactic reactions occurring within 24 hours after antivenom. RESULTS: Reactions occurred in 12 of 49 patients treated with promethazine (24%) and in 13 of 52 given placebo (25%); most were mild or moderate. Continuous sequential analysis indicated that the study could be interrupted at the 22nd untied pair, without preference for promethazine or placebo. CONCLUSION: Prophylaxis with promethazine does not prevent early reactions. Patients should be observed carefully during antivenom infusion and the subsequent few hours. (+info)Crystallization and preliminary X-ray diffraction analysis of a myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom. (2/183)
Crystals of a myotoxic phospholipase A(2) from Bothrops neuwiedi pauloensis have been obtained. They diffracted at 2.5 A resolution using a synchrotron radiation source and belong to space group P3(1)21. Preliminary analysis shows that there are two molecules in the asymmetric unit. (+info)"RKKH" peptides from the snake venom metalloproteinase of Bothrops jararaca bind near the metal ion-dependent adhesion site of the human integrin alpha(2) I-domain. (3/183)
Integrin alpha(1)beta(1) and alpha(2)beta(1) are the major cellular receptors for collagen, and collagens bind to these integrins at the inserted I-domain in their alpha subunit. We have previously shown that a cyclic peptide derived from the metalloproteinase domain of the snake venom protein jararhagin blocks the collagen-binding function of the alpha(2) I-domain. Here, we have optimized the structure of the peptide and identified the site where the peptide binds to the alpha(2) I-domain. The peptide sequence Arg-Lys-Lys-His is critical for recognition by the I-domain, and five negatively charged residues surrounding the "metal ion-dependent adhesion site" (MIDAS) of the I-domain, when mutated, show significantly impaired binding of the peptide. Removal of helix alphaC, located along one side of the MIDAS and suggested to be involved in collagen-binding in these I-domains, does not affect peptide binding. This study supports the notion that the metalloproteinase initially binds to the alpha(2) I-domain at a location distant from the active site of the protease, thus blocking collagen binding to the adhesion molecule in the vicinity of the MIDAS, while at the same time leaving the active site free to degrade nearby proteins, the closest being the beta(1) subunit of the alpha(2)beta(1) cell-surface integrin itself. (+info)Histologic and functional renal alterations caused by Bothrops moojeni snake venom in rats. (4/183)
Acute renal failure (ARF) is the main cause of death following snake bites by Bothrops species. In this study, we investigated the morphologic and functional renal disturbances caused by Bothrops moojeni venom in rats. Renal function was assessed based on creatinine and lithium clearances and on histologic examination of renal tissue 5 hr after the intravenous administration of 0.2 mg of venom/kg and 5 hr, 16 hr, and 48 hr after 0.4 mg of venom/ kg. A venom dose of 0.4 mg/kg produced renal tubule disturbances, including acute impairment of proximal and post-proximal tubule sodium handling associated with acute tubule necrosis. The glomerular filtration rate (GFR) decreased significantly and was accompanied by severe morphologic disturbances in the renal glomeruli. These functional and morphologic findings were observed in the absence of any change in mean arterial blood pressure. The decrease in GFR was not related to the presence of fibrin deposits in the glomerular capillary loops. These results suggest an early nephrotoxic action of B. moojeni venom involving significant morphologic and functional changes similar to those observed in snakebite-induced ARF in humans. (+info)Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties. (5/183)
Myotoxic phospholipases A(2) (PLA(2)s; group II) account for most of the muscle-tissue damage that results from envenomation by viperid snakes. In the venom of the Godman's viper (Cerrophidion godmani, formerly Bothrops godmani), an enzymically active PLA(2) (myotoxin I) and an inactive, Lys-49 variant (myotoxin II) induce extensive muscle damage and oedema. In this study, two distinct myotoxin inhibitor proteins of C. godmani, CgMIP-I and CgMIP-II, were purified directly from blood plasma by selective binding to affinity columns containing either myotoxin I or myotoxin II, respectively. Both proteins are glycosylated, acidic (pI=4) and composed of 20-25-kDa subunits that form oligomers of 110 kDa (CgMIP-I) or 180 kDa (CgMIP-II). In inhibition studies, CgMIP-I specifically neutralized the PLA(2) and the myotoxic, oedema-forming and cytolytic activities of myotoxins I, whereas CgMIP-II selectively inhibited the toxic properties of myotoxin II. N-terminal amino acid sequence analysis and sequencing of cDNAs encoding the two inhibitors revealed that CgMIP-I is similar to gamma-type inhibitors, which share a pattern of cysteine residues present in the Ly-6 superfamily of proteins, whereas CgMIP-II shares sequence identity with alpha-type inhibitors that contain carbohydrate-recognition-like domains, also found in C-type lectins and mammalian PLA(2) receptors. N-terminal sequencing of myotoxin I revealed a different primary structure from myotoxin II [De Sousa, Morhy, Arni, Ward, Diaz and Gutierrez (1998) Biochim. Biophys. Acta 1384, 204-208], which provides insight into the nature of such pharmacological specificity. (+info)Antibody from mice immunized with DNA encoding the carboxyl-disintegrin and cysteine-rich domain (JD9) of the haemorrhagic metalloprotease, Jararhagin, inhibits the main lethal component of viper venom. (6/183)
Envenoming by the Brazilian pit viper, Bothrops jararaca, induces extensive local and systemic haemorrhage in humans. The severe and occasionally lethal outcome of envenoming is prevented only by administration of antivenom which is conventionally prepared by hyperimmunization of large animals with an individual venom or a range of venoms. Since snake venoms typically consist of numerous molecules, only some of which are toxic, antivenoms are antigenically crude preparations whose therapeutic value would theoretically be enhanced by restricting antibody specificity to toxic venom molecules. We report here that high-titre IgG antibody from mice immunized by the GeneGun with DNA encoding the carboxy-terminal JD9 domain of Jararhagin, a haemorrhage-inducing metalloprotease in B. jararaca venom, extensively neutralized the main lethal component of B. jararaca venom. This is to our knowledge the first study to apply DNA-based methods to preparation of antivenom; it represents a novel approach with greater immunological specificity and fewer hazards than conventional systems of antivenom production. (+info)Basic residues of human group IIA phospholipase A2 are important for binding to factor Xa and prothrombinase inhibition comparison with other mammalian secreted phospholipases A2. (7/183)
Human secreted group IIA phospholipase A2 (hGIIA) was reported to inhibit prothrombinase activity because of binding to factor Xa. This study further shows that hGIIA and its catalytically inactive H48Q mutant prolong the lag time of thrombin generation in human platelet-rich plasma with similar efficiency, indicating that hGIIA exerts an anticoagulant effect independently of phospholipid hydrolysis under ex vivo conditions. Charge reversal of basic residues on the interfacial binding surface (IBS) of hGIIA leads to decreased ability to inhibit prothrombinase activity, which correlates with a reduced affinity for factor Xa, as determined by surface plasmon resonance. Mutation of other surface-exposed basic residues, hydrophobic residues on the IBS, and His48, does not affect the ability of hGIIA to inhibit prothrombinase activity and bind to factor Xa. Other basic, but not neutral or acidic, mammalian secreted phospholipases A2 (sPLA2s) exert a phospholipid-independent inhibitory effect on prothrombinase activity, suggesting that these basic sPLA2s also bind to factor Xa. In conclusion, this study demonstrates that the anticoagulant effect of hGIIA is independent of phospholipid hydrolysis and is based on its interaction with factor Xa, leading to prothrombinase inhibition, even under ex vivo conditions. This study also shows that such an interaction involves basic residues located on the IBS of hGIIA, and suggests that other basic mammalian sPLA2s may also inhibit blood coagulation by a similar mechanism to that described for hGIIA. (+info)Local haemorrhage induced by Bothrops jararaca venom: relationship to neurogenic inflammation. (8/183)
We investigated morphological alterations induced by s.c. injection of 2.5 microg of Bothrops jararaca venom in rats. Intense disorganisation of collagen fibres was observed 1 min after the venom injection, particularly at regions near vessels and nerves. Mast cells were degranulated, and erythrocytes were seen leaving venules throughout the endothelial junctions. At this time, damaged endothelial cells were not observed. In rats envenomed as above, but immediately after cardiorespiratory failure induced by deep ether anaesthesia, alterations in the connective tissue structures, as previously described, were not observed. The mediation of this haemorrhage was investigated by injecting the venom into the foot pad of mice and compared to the mediation of oedema. Local haemorrhage was significantly reduced in mice pre-treated with capsaicin or guanethidine or submitted to a surgical section of sciatic and saphenous nerves. In these animals, oedema was not affected. Groups treated with methysergide or morphine showed both haemorrhage and oedema significantly reduced. Indomethacin or dexamethasone pre-treatments significantly reduced the oedema, but not the haemorrhage. Moreover, in animals treated with promethazine or mepyramine, oedema and haemorrhage were not affected. These data suggest that local haemorrhage induced by Bothrops jararaca venom is partially controlled by serotonin and neurohumoral mediators. Furthermore, results indicate that haemorrhage and oedema are mediated by different pharmacological systems. (+info)
Rapid purification of serine proteinases from Bothrops alternatus and Bothrops moojeni venoms
Neutralization of myonecrosis, hemorrhage, and edema induced by Bothrops asper snake venom by homologous and heterologous pre...
Acervo Digital: Molecular cloning and biochemical characterization of a myotoxin inhibitor from Bothrops alternatus snake plasma
Recombinant Bothrops jararaca Thrombin-like enzyme TL-BJ 2[Thrombin-like enzyme TL-BJ 2] - thrombrin - a serine protease...
BOTHROPS JARARACUSSU PDF
BOTHROPS LANCEOLATUS. - THE ENCYCLOPEDIA OF PURE MATERIA MEDICA By TIMOTHY F. ALLEN, A.M.,
M.D.
Estudo do efeito da Alternagina-C, uma desintegrina do veneno de Bothrops alternatus e de um peptídeo sintético derivado de sua...
NPP-BJ, a nucleotide pyrophosphatase/phosphodiesterase from Bothrops jararaca snake venom, inhibits platelet aggregation. |...
Local haemorrhage induced by Bothrops jararaca venom: relationship to neurogenic inflammation
Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops...
SciELO - Journal of Venomous Animals and Toxins, Volume: 8, Issue: 2, Published: 2002
Isolation of a myotoxin from Bothrops asper venom: Partial characterization and action on skeletal muscle
Envenenamento experimental por Bothrops jararaca em camundongos prenhes: Eficácia do soro antibotrópico
Bothrops asper - Wikipedia
L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis. | Sigma-Aldrich
Repositorio da Producao Cientifica e Intelectual da Unicamp: Insights into the loss of muscle mass following B. jararacussu...
Quantitation by enzyme-immunoassay of antibodies against Bothrops myotoxins in four commercially-available antivenoms
SABIIA - Sistema Aberto e Integrado de Informação em Agricultura (Sabiia)
Repositorio da Producao Cientifica e Intelectual da Unicamp: Effect Of Bothrops Insularis Venom On The Mouse And Chick Nerve...
Toxins | Free Full-Text | Isolation and Functional Characterization of an Acidic Myotoxic Phospholipase A2 from Colombian...
Thrombin-like enzyme BjussuSP-1 - Bothrops jararacussu (Jararacussu)
Bmoo FIBMP-I: A New Fibrinogenolytic Metalloproteinase from Bothrops moojeni Snake Venom
Crystallization and preliminary diffraction data of two myotoxins isolated from the venoms of Bothrops asper (Terciopelo) and...
ReP USP - Detalhe do registro: Enhancement of the citrulline-nitric oxide cycle in astroglioma cells by the proline-rich...
alpha(1)-adrenoceptors trigger the snake venom production cycle in secretory cells by activating phosphatidylinositol 4,5...
Toxins | Free Full-Text | Molecular Characterization of Lys49 and Asp49 Phospholipases A2 from Snake Venom and Their Antiviral...
Acervo Digital: Renal and cardiovascular effects of Bothrops marajoensis venom and phospholipase A(2)
Avaliação da transferência passiva de imunoglobulinas específicas do gênero Bothrops de éguas hiperimunizadas para o neonato -...
CiNii Articles -
3-D Structure of Botrocetin, a von Willebrand Factor Modulator Protein from Snake Venom of Bothrops...
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Natural phospholipase A(2) myotoxin inhibitor proteins from snakes, mammals and plants
br Cytosolic lactate dehydrogenase LDH is used
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Kinetic investigations and stability studies of two Bothrops L-amino acid oxidases | Journal of Venomous Animals and Toxins...
Bothrops pirajai snake venom L-amino acid oxidase: in vitro effects on infection of Toxoplasma gondii in human foreskin...
THE COAGULATION OF BLOOD BY SNAKE VENOMS AND ITS PHYSIOLOGIC SIGNIFICANCE | JEM
Distinct sites for myotoxic and membrane-damaging activities in the C-terminal region of a Lys49-phospholipase A2 | Biochemical...
Snake venomics of Bothrops punctatus, a semiarboreal pitviper species from Antioquia, Colombia [PeerJ]
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Potent virucidal activity against Flaviviridae of a group IIA phospholipase A2 isolated from the venom of Bothrops asper
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Queensland Groper Epinephelus lanceolatus Stock Photo
Queensland Groper Epinephelus lanceolatus Stock Photo
Ammospermophilus leucurus - Wikispecies
Cynomys leucurus - Wikispecies
WoRMS - World Register of Marine Species - Masturus lanceolatus (Liénard, 1840)
Online Virtual Flora of Wisconsin - Streptopus lanceolatus
Bothrocophias lojanus
Bothrops lojanus. The IUCN Red List of Threatened Species 2019: e.T174144A54445329. Downloaded on 19 July 2019. McDiarmid RW, ... ISBN 1-893777-00-6 (series). ISBN 1-893777-01-4 (volume). "Bothrops". Integrated Taxonomic Information System. Retrieved 3 ...
Bothrocophias colombianus
ISBN 1-893777-00-6 (series). ISBN 1-893777-01-4 (volume). "Bothrops". Integrated Taxonomic Information System. Retrieved 3 ... Bothrops microphthalmus colombianus, p. 15.) v t e. ...
Saint Lucia lancehead
The Saint Lucia lancehead or Saint Lucia pit viper (Bothrops caribbaeus) is a Endangered species of venomous snake from the ... www.iccs.org.uk/wp-content/thesis/consci/2009/Breach.docx Bothrops caribbaeus at the Reptile Database v t e. ... "Clinical and immunological aspects of envenomations by Bothrops snakes". Journal of Venomous Animals and Toxins including ... Bothrops caribbaeus. The IUCN Red List of Threatened Species 2019: e.T50956889A50956898. https://dx.doi.org/10.2305/IUCN.UK. ...
Erpetogomphus
Paulson, D. R. (2009). "Erpetogomphus bothrops". IUCN Red List of Threatened Species. 2009: e.T165051A5975649. doi:10.2305/IUCN ... 1859 Erpetogomphus bothrops Garrison, 1994 - one-striped ringtail Erpetogomphus compositus Hagen in Selys, 1858 - white-belted ...
Bothrocophias andianus
"Bothrops andiana sp. nov.", pp. 103-105). Bothrocophias andianus at the Reptarium.cz Reptile Database. Accessed 12 August 2008. ...
Bothriechis rowleyi
Bothrops rowleyi, new species). Heimes P (2016). Snakes of Mexico: Herpetofauna Mexicana Vol. I. Frankfurt, Germany: Chimaira. ... ISBN 978-1-4214-0135-5. (Bothriechis rowleyi, p. 228). Bogert CM (1968). "A New Arboreal Pit Viper of the Genus Bothrops from ...
Cerrophidion tzotzilorum
Bothrops tzotzilorum, new species). Heimes P (2016). Snakes of Mexico: Herpetofauna Mexicana Vol I. Frankfurt am Main, Germany ... Campbell JA (1985). "A New Species of Highland Pitviper of the Genus Bothrops from Southern Mexico". Journal of Herpetology 19 ...
Porthidium nasutum
"Bothrops nasutus n. sp.", p. 202.) Porthidium nasutum at Honduras Silvestre. Accessed 12 February 2008.. ... Descriptions de quelques Crotaliens nouveaux appartenant au genre Bothrops, recueillis dans le Guatémala. Annales des sciences ...
Clodoveo Carrión Mora
Reptiles: Atractus carrioni Parker, 1930; Bothrops lojanus Parker, 1930; Stenocercus carrioni Parker, 1934. Arthropods: ...
Snake venom
The chicken snake (Spilotes pullatus) is the enemy of the fer-de-lance (Bothrops caribbaeus) in St. Lucia, and in their ... In Brazil, serum prepared with the venom of lanceheads (Bothrops spp.) is without action on rattlesnake (Crotalus spp.) venom. ... Bothrops spp.); and the African adders (Bitis spp.), night adders (Causus spp.), and horned vipers (Cerastes spp.), cause fatal ...
Bothrocophias campbelli
Bothrops pulchra - Amaral, 1923, and Bothrops pulcher - J.Peters & Orejas-Miranda, 1970. Campbell and Lamar (1992) considered ... Bothrops campbelli, new species). (in Spanish). Bothrocophias campbelli at the Reptarium.cz Reptile Database. Accessed 27 ... Schätti and Kramer (1993) argued that Bothrops campbelli (Freire-Lascano, 1991) was a nomen invalidum and suggested a new name ... de altura [4,900-6,600 feet]". In previous accounts, Bothrocophias campbelli has often been included in Bothrops pulcher (W. ...
Porthidium ophryomegas
"Bothrops ophryomegas n. sp.") Porthidium ophryomegas at the Reptarium.cz Reptile Database. Accessed 6 August 2008.. ... Descriptions de quelques Crotaliens nouveaux appartenant au genre Bothrops, recueillis dans le Guatémala. Annales des sciences ...
Great American Interchange
Lanceheads (Bothrops). *Bushmasters (Lachesis). *Other pit vipers (Bothriechis schlegelii, Bothriopsis, Porthidium)[188] ...
Tropidolaemus wagleri
Bothrops] philippensis - Maslin, 1942. *Tropidolaemus wagleri - Hoge & Romano-Hoge, 1981. *Tropidolaemus philippinensis - David ...
Bothriechis marchi
"On some Hondurian and Guatemalan snakes with the description of a new arboreal pit viper of the genus Bothrops ". Bulletin of ... the Antivenin Institute of America 3: 1-3. (Bothrops nigroviridis marchi, new subspecies).. ...
Protobothrops flavoviridis
Bothrops flavoviridis, pp. 492-493.) Protobothrops flavoviridis at the Reptarium.cz Reptile Database. Accessed 25 July 2007.. ...
Adolfo Lutz
... and Bothrops lutzi, a venomous snake. For his work on tropical diseases, Lutz received a nomination for the Nobel Prize in ...
Bothrocophias microphthalmus
Bothrops microphthalmus, new species, pp. 182-183). v t e. ...
Trimeresurus hageni
"Bothrops Hageni", new species, pp. 53-54). Sanders KL, Malhotra A, Thorpe RS (2002). "A contribution to the systematics of two ...
GP1BA
Andrews RK, Booth WJ, Gorman JJ, Castaldi PA, Berndt MC (1989). "Purification of botrocetin from Bothrops jararaca venom. ...
Taipoxin
Gutiérrez JM, Lomonte B (November 1995). "Phospholipase A2 myotoxins from Bothrops snake venoms". Toxicon. 33 (11): 1405-24. ... a lysine-49 phospholipase A2 of Bothrops asper snake venom". Toxicon. 32 (11): 1359-69. doi:10.1016/0041-0101(94)90408-1. PMID ...
Cerastocytin
For example, botrocetin, found in the venom of Bothrops jararaca, activates von Willebrand factor (vWF) by inducing it to bind ... In contrast, cerastocytin and cerastotin (from the venom of Cerastes cerastes), as well as thrombocytin (from Bothrops atrox) ... 74(3):1031-5 Niewiarowski S, Kirby EP, Brudzynski TM, Stocker K. (1979) Thrombocytin, a serine protease from Bothrops atrox ... 74(3):1031-5 Bothrops atrox venom. 2. Interaction with platelets and plasma-clotting factors. Biochemistry. 18(16):3570-7. ...
Venombin A
Stocker K, Barlow GH (1976). "The coagulant enzyme from Bothrops atrox venom (batroxobin)". Methods in Enzymology. 45: 214-23. ...
Glycoprotein IX
1990). "Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von ...
List of venomous animals
Bothrops spp.), including the fer-de-lance (B. lanceolatus) and the terciopelo (B. asper) Bushmasters (Lachesis spp.) ...
Teprotide
... is nonapeptide which has been isolated from the snake Bothrops jararaca. It is an angiotensin converting enzyme ... Ferreira, Sergio (February 1965). "A bradykinin-potentiating factor (bpf) present in the venom of bothrops jararaca". British ... "Angiotensin-converting enzyme inhibitors from the venom of bothrops jararaca. Isolation, elucidation of structure, and ... "Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom". Biochemistry. 9 (13): 2583-2593. doi:10.1021/ ...
Philodryas olfersii
Philodryas does not cause the coagulopathy that Bothrops does. Only one fatality has been reported, and that in a child. The ... Patients complaining of snakebite may be given an antivenom for Bothrops snake venom, which is inappropriate for the treatment ... higher than Bothrops jararaca, in addition to containing neurotoxic properties, In mice, doses such as 5.6 µg / 20g result in ... equivalent to the lethality of Bothrops asper. However, due to the anatomy of their inoculating teeth located in the posterior ...
Epidemiology of snakebites
Of these, Bothrops asper is the most important species, partly because it is abundant in lowland areas and partly because it is ... Hardy, D. L. (1994). "Bothrops asper (Viperidae) snakebite and field researchers in Middle America". Biotropica. 26 (2): 198- ... "Complications of Bothrops, Porthidium, and Bothriechis snakebites in Colombia. A clinical and epidemiological study of 39 cases ...
Metlapilcoatlus
Notes on Bothrops nummifera, mano de piedra or timbo. Bulletin of the Antivenin Institute of America. 2(3): 58. Müller JW von. ... Phylogenetic relationships of Central and South American pitvipers of the genus Bothrops (sensu lato): cladistic analyses of ...
Porthidium hespere
Bothrops hesperis) Porthidium hespere at the Reptarium.cz Reptile Database. Accessed 15 September 2007.. ... A New Terrestrial Pit Viper of the Genus Bothrops (Reptilia, Serpentes, Crotalidae) from western Mexico. Journal of Herpetology ...
Bothrops - Wikipedia
Bothrops is a genus of highly venomous pit vipers endemic to Central and South America. The generic name, Bothrops, is derived ... Many species of Bothrops exhibit tail vibration behavior when disturbed. Members of this genus are responsible for more ... This species, unlike most Bothrops, preys primarily on birds, due to the absence of native mammal species on Queimada Grande. ... Found in northeastern Mexico (Tamaulipas) southward through Central and South America to Argentina, Bothrops species also occur ...
Bothrops insularis - Wikipedia
"Pharmacological evidence for a presynaptic action of venoms from Bothrops insularis (jararaca ilhoa) and Bothrops neuwiedi ( ... Sexually mature Bothrops insularis mate during August and September, and have been known to mate both in the trees and on the ... Bothrops insularis can usually be found either in the trees hunting for its prey, or seeking shelter among leaf litter or in ... Adult Bothrops insularis are the only animals on the island of Queimada Grande that have been reported to eat birds. There are ...
Bothrops ammodytoides - Wikispecies
Bradykinin-Potentiating Peptides from the Venom of Bothrops Jararaca | SpringerLink
Bothrops brazili Amaral, 1923
Bothrops species Bothrops brazili Name. Synonyms. Bothrops neglectus Amaral, 1923. Homonyms. Bothrops brazili Amaral, 1923. ... Bothrops brazili Amaral, 1923 Dataset GBIF Backbone Taxonomy Rank SPECIES Classification. kingdom Animalia phylum Chordata ... Hoge,A.R. (1954) A new Bothrops from Brazil - Bothrops brazili, sp. nov.: Mem. Inst. Butantan 25: 15-21 [1953] ... Bothrops brazili Hoge, 1954. Common names. Brazils Lancehead in English. Bibliographic References. * Amaral,A. do (1923) New ...
Snaclec aspercetin subunit beta - Bothrops asper (Terciopelo)
"Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces ... "Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces ... "Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces ... sp,P0DJC9,SLB_BOTAS Snaclec aspercetin subunit beta (Fragment) OS=Bothrops asper OX=8722 PE=1 SV=1 ...
Bradykinin-potentiating peptide 11g - Bothrops jararaca (Jararaca)
"Peptidomics of three Bothrops snake venoms: insights into the molecular diversification of proteomes and peptidomes.". Tashima ... "Peptidomics of three Bothrops snake venoms: insights into the molecular diversification of proteomes and peptidomes.". Tashima ... "Peptidomics of three Bothrops snake venoms: insights into the molecular diversification of proteomes and peptidomes.". Tashima ... Bothrops jararaca (Jararaca) (Bothrops jajaraca). ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_ ...
Cytokine profile of Ehrlich ascites tumor treated with Bothrops jararaca venom
Local haemorrhage induced by Bothrops jararaca venom: relationship to neurogenic inflammation
Habitat Selection by Bothrops atrox (Serpentes: Viperidae) in Central Amazonia, Brazil
Rafael de Fraga, William E. Magnusson, Carlos R. Abrahão, Tania Sanaiotti, and Albertina P. Lima "Habitat Selection by Bothrops ... Habitat Selection by Bothrops atrox (Serpentes: Viperidae) in Central Amazonia, Brazil. Rafael de Fraga, William E. Magnusson, ... Rafael de Fraga, William E. Magnusson, Carlos R. Abrahão, Tania Sanaiotti, Albertina P. Lima "Habitat Selection by Bothrops ... Bothrops atrox). We estimated densities and probabilities of detection of snakes in riparian and upland plots in Reserva Ducke ...
Phylogenie der Gattung Bothrops
Bothrops, Bothrocophias), with the aim to solve systematic conflicts within the Bothrops-complex (~50 species) using a ... Bothrops diporus shall serve as a model species for studying possible influences of environmental factors on the phenotypical ... As part of this project we are currently working on a systematic revision of the Bothrops-complex in Peru (11 + 2 new species ... Startseite , Forschung , Projekte , Phylogenie der Gattung Bothrops , Menu position router , Menu position router ...
WikiGenes - Bothrops
Increments in serum cytokine and nitric oxide levels in mice injected with Bothrops asper and Bothrops jararaca snake venoms. ... Associations of Bothrops with chemical compounds. *Heparin binds to phospholipase A2 myotoxins from Bothrops asper snake venom ... Biological context of Bothrops. *A 1.8-kb cDNA clone was isolated from a Bothrops jararaca venom gland cDNA library that ... High impact information on Bothrops. *Cloning and sequence analysis of a Bothrops jararaca cDNA encoding a precursor of seven ...
Darkinal (Bothrops Atrox; Heparin Sodium) Llorente
Jararhagin, a hemorrhagic snake venom metalloproteinase from Bothrops jararaca.
Jararaca (Bothrops jararaca) longevity, ageing, and life history
Morfologia dos fotorreceptores e genética dos pigmentos visuais de Bothrops jararaca...
Morfologia dos fotorreceptores e genética dos pigmentos visuais de Bothrops jararaca e Crotalus durissus terrificus (Serpentes ... Bothrops jararaca e Crotalus durissus terrificus. Três indivíduos de cada espécie foram obtidos junto ao laboratório de ... Bothrops jararaca and Crotalus durissus terrificus. Three subjects of each species were collected at the Butantan Institute. ...
Purificación y caracterización de la l-amino ácido oxidasa del veneno de la serpiente Bothrops brazili 'jergón shushupe' - DOAJ
Se ha purificado y caracterizado parcialmente la L-aminoácido oxidasa de la serpiente Bothrops brazili. El aislamiento se ... Purificación y caracterización de la l-amino ácido oxidasa del veneno de la serpiente Bothrops brazili jergón shushupe * ... Se ha purificado y caracterizado parcialmente la L-aminoácido oxidasa de la serpiente Bothrops brazili. El aislamiento se ...
L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis. | Sigma-Aldrich
Bothrops jararacussu venom-induced neuromuscular blockade inhibited by Casearia gossypiosperma Briquet hydroalcoholic extract
Bothrops venom. Crude venom was obtained from adult Bothrops jararacussu (Bjssu) snakes (Serpentarium of the Nature Study ... In vivo myotoxic effects and in vitro irreversible neuromuscular blockade effects of crude venom from the snake Bothrops ... Rodrigues-Simioni L, Borgese N, Ceccarelli B. The effects of Bothrops jararacussu venom and its components on frog nerve-muscle ... Neutralization of the neuromuscular activity of bothropstoxin-I, a myotoxin from Bothrops jararacussu snake venom, by a ...
Efeitos de toxinas com estrutura de fosfolipase A2, isoladas do veneno de Bothrops...
... isoladas de Bothrops asper (VBa) e CB2, de Crotalus durissus terrificus (VCdt) e os venenos brutos, sobre a expressão de ... Efeitos de toxinas com estrutura de fosfolipase A2, isoladas do veneno de Bothrops asper e Crotalus durissus terrificus, e dos ... A ação de fosfolipases A2 (FLA2s): miotoxinas (MTs) ?II e III, isoladas de Bothrops asper (VBa) e CB2, de Crotalus durissus ... Action of the phospholipase A2 (PLA22): myotoxins (MTs) -II and -III, from Bothrops asper (BaV) and CB2, from Crotalus durissus ...
Bothrops lutzi | The Reptile Database
Bothrops iglesiasi - RODRIGUES 2003. Bothrops lutzi - SILVA in CAMPBELL & LAMAR 2004. Bothrops lutzi - JANSEN 2008. Bothrops ... Bothrops iglesiasi - PETERS et al. 1970: 46. Bothrops neuwiedi lutzi - PETERS & OREJAS-MIRANDA 1970: 50. Bothrops iglesiasi - ... Bothrops neuwiedi lutzi - AMARAL 1929: 238. Bothrops neuwiedi lutzi HOGE 1966 [1965]: 128. Bothrops neuwiedi piauhyensis HOGE ... Bothrops iglesiasi AMARAL 1923: 97. Bothrops neuwiedi bahiensis AMARAL 1925: 57. Bothrops neuwiedi piauhyensis AMARAL 1925: 58 ...
Bothrops diporus | The Reptile Database
Bothrops diporus - SILVA in CAMPBELL & LAMAR 2004. Bothrops diporus - TRUTNAU 2008. Bothrops diporus - DA SILVA & RODRIGUES ... Bothrops neuwiedi diporus PETERS & OREJAS-MIRANDA 1970: 50. Bothrops neuwiedi diporus - CEI 1993. Bothrops neuwiedi diporus - ... Bothrops neuwiedi meridionalis AMARAL 1930: 66 (preoccupied). Bothrops neuwiedi diporus - COCHRAN 1961: 151. Bothrops neuwiedi ... Bothrops diporus COPE 1862: 347. Bothrops diporus - BOULENGER 1886: 438. Lachesis neuwiedi BOULENGER 1896 (part.). Lachesis ...
NPP-BJ, a nucleotide pyrophosphatase/phosphodiesterase from Bothrops jararaca snake venom, inhibits platelet aggregation. |...
Toxins | Free Full-Text | Isolation and Functional Characterization of an Acidic Myotoxic Phospholipase A2 from Colombian...
A new myotoxic acidic Asp49 PLA2 (BaCol PLA2) was isolated from Colombian Bothrops asper venom using reverse-phase high ... BaCol PLA2 showed structural homology with other acidic PLA2 isolated from Bothrops venoms, including a non-myotoxic PLA2 from ... are responsible for many clinical manifestations in envenomation by Bothrops snakes. ... Keywords: acidic myotoxic phospholipase A2; Bothrops asper; edema; myotoxicity; snake venom acidic myotoxic phospholipase A2; ...
Neutralizing capacity of a new monovalent anti-Bothrops atrox antivenom: comparison with two commercial antivenoms
Biological characterization of Bothrops marajoensis snake venom - Library Publishing Media
Toxins | Free Full-Text | Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced...
... and wild forms have previously been shown to inhibit some toxic activities of Bothrops asper snake venom if preincubated before ... Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: ... Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: ... "Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: ...
Sequence Similarity
- 1GOD: MONOMERIC LYS-49 PHOSPHOLIPASE A2 HOMOLOGUE ISOLATED FROM THE VENOM OF CERROPHIDION ...
RCSB PDB - 1Z76: Crystal structure of an acidic phospholipase A2 (BthA-I) from Bothrops jararacussu venom complexed with p...
Crystal structure of an acidic phospholipase A2 (BthA-I) from Bothrops jararacussu venom complexed with p-bromophenacyl bromide ... The crystal structure of an acidic phospholipase A(2) isolated from Bothrops jararacussu venom (BthA-I) chemically modified ... The crystal structure of an acidic phospholipase A(2) isolated from Bothrops jararacussu venom (BthA-I) chemically modified ...
OCCIPITAL INFARCTION REVEALED BY QUADRANOPSIA FOLLOWING SNAKEBITE BY BOTHROPS LANCEOLATUS | The American Journal of Tropical...
The patient, a 46-year-old man, was bitten on the right thumb by Bothrops lanceolatus. Treatment with a specific equine ... f OCCIPITAL INFARCTION REVEALED BY QUADRANOPSIA FOLLOWING SNAKEBITE BY BOTHROPS LANCEOLATUS * HAROLD MERLE1,*, ANGÉLIQUE DONNIO ... Multiple cerebral infarctions following a snakebite by Bothrops caribbaeus. Am J Trop Med Hyg 67 : 287-288. ... The patient, a 46-year-old man, was bitten on the right thumb by Bothrops lanceolatus. Treatment with a specific equine ...
GenusVenomsEnvenomationSpeciesAtroxAlternatusMoojeni snake venomSnakesSerpentesAsper venomJararacussu venomCrotalusMyotoxinAntivenomInsularisLanceolatusVeneno de la serpiente peruanaPitviperSnakebiteIsolated from the venomHogeBjssuVenenosCharacterizationToxinSystemicReptile DatabaseMyotoxinsBraziliBrazilNeuromuscularSnake venom metalloproteinasePLA21966AmaralPlatelet aggregationEnvenomationsProteinCrude
Genus19
- Bothrops is a genus of highly venomous pit vipers endemic to Central and South America. (wikipedia.org)
- The species is named for the light yellowish-brown color of its underside and for its head shape that is characteristic of the genus Bothrops. (wikipedia.org)
- The name "lancehead" refers to the distinctive head shape of all snakes in the genus Bothrops, which is somewhat elongated and comes to a point at the nose. (wikipedia.org)
- Chemical analysis of the venom of B. insularis suggests that it is five times as potent as that of B. jararaca and is the fastest acting venom in the genus Bothrops. (wikipedia.org)
- Within the genus Bothrops, the closest living relative of the golden lancehead is B. jararaca. (wikipedia.org)
- Salomão, M.G., W. Wüster, R.S. Thorpe & BBBSP (1999) MtDNA phylogeny of Neotropical pitvipers of the genus Bothrops (Squamata: Serpentes: Viperidae). (gbif.org)
- Until recently, most phylogenetic analyses of the South American pitviper genus Bothrops used exclusively mitochondrial DNA sequences, whereas few of them have included morphological traits. (zfmk.de)
- Bothrops diporus shall serve as a model species for studying possible influences of environmental factors on the phenotypical diversity of species in the genus Bothrops. (zfmk.de)
- In Brazil, the genus Bothrops is a major group of snakes that commonly cause envenomation. (biomedcentral.com)
- Snakebites from this genus, which includes those of Bothrops jararacussu , are characterized by local and systemic effects, such as inflammation at the bite site, ecchymosis, bleeding, and skin infection with abscess. (biomedcentral.com)
- The genus Bothrops is widespread throughout Central and South America and is the principal cause of snakebite in these regions. (biomedcentral.com)
- The genus Bothrops is responsible for most cases of snakebite throughout Latin America [ 21 ] and in Brazil accounts for 80-90% of bites by venomous snakes. (biomedcentral.com)
- Genus: Bothrops. (argentinamotoadventure.com)
- Although there have been studies that demonstrate the application of photobiomodulation in the treatment of local adverse events due to snakebites from snakes of the genus Bothrops , its role in the activation of leukocytes , particularly macrophages , has not been evaluated. (bvsalud.org)
- Several crystal structures of Lys49 PLA2s from genus Bothrops have already been solved, revealing very similar fold patterns. (eurekaselect.com)
- Fer-de-lance' meaning 'spear head, is a common name given to the variety of snakes from the genus Bothrops, a group of snakes also known as pit vipers. (ypte.org.uk)
- The PLA 2 isoforms are divided into two categories: neurotoxic (family Elapidae - genus micrurus ) and non-neurotoxic (family Viperidae - genera Crotalus and Bothrops ) [ 23 ]. (biomedcentral.com)
- The isoforms isolated from snakes belonging to the genus Bothrops are the main venom components that account for cell damage mediated by hydrolysis of membrane phospholipids [ 24 ]. (biomedcentral.com)
- This is the first study that characterizes genetic variability for this important species of the Bothrops genus , and our data are of significant importance in terms of classifying populations in relation to their conservational value and management strategies. (geneticsmr.com)
Venoms15
- Effects of toxins with phospholipase A2 structure isolated from Bothrops asper and Crotalus durissus terrificus venoms and the respective crude venoms on expression of cyclooxygenases and biosynthesis of prostaglandins. (usp.br)
- Action of the phospholipase A 2 (PLA 2 2): myotoxins (MTs) -II and -III, from Bothrops asper (BaV) and CB2, from Crotalus durissus terrificus (CdtV) and these venoms on cyclooxygenases (COXs) and synthesis of prostaglandins (PGs) E 2 and D 2 were studied in vivo and in vitro. (usp.br)
- BaCol PLA 2 showed structural homology with other acidic PLA 2 isolated from Bothrops venoms, including a non-myotoxic PLA 2 from Costa Rican B. asper . (mdpi.com)
- The mature svVEGF appears to be ubiquitously distributed throughout snake venoms and was also confirmed by Northern blot studies of other related Viperidae species and by cDNA cloning of svVEGF from Bothrops jararaca pit viper. (reliatech.de)
- Bothrops alternatus venom gland contains the major toxin classes described for other Bothrops venoms based on trancriptomic and proteomic studies. (biomedcentral.com)
- A rapid, three-step, chromatographic procedure was developed to routinely purify serine proteinases from the venoms of Bothrops alternatus and Bothrops moojeni. (unesp.br)
- The partial sequences indicated that these enzymes share high identity with serine proteinases from the venoms of other Bothrops species. (unesp.br)
- Phospholipases A(2) (PLA(2)s) are important components of Bothrops snake venoms, that can induce several effects on envenomations such as myotoxicity, inhibition or induction of platelet aggregation and edema. (unesp.br)
- An inhibitory protein that neutralizes the enzymatic and toxic activities of several PLA2s from Bothrops venoms was isolated from Bothrops alternatus snake plasma by affinity chromatography using the immobilized myotoxin BthTX-I on CNBr-activated Sepharose. (unesp.br)
- 1993). Crystallization and preliminary diffraction data of two myotoxins isolated from the venoms of Bothrops asper (Terciopelo) and Bothrops nummifer (jumping viper). (core.ac.uk)
- 1995). Phospholipase a(2), myotoxins from bothrops snake-venoms. (core.ac.uk)
- 2015). Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways. (ke-i.org)
- Secretory phospholipases A2 isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases by: Moreira, Vanessa, et al. (csuca.org)
- Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo by: Zamunér, Stella Regina, et al. (csuca.org)
- The venoms of Bothrops (Rhinocerophis) alternatus (B.a.) from different regions of Argentina have shown biochemical, toxicological and immunological variations. (elsevier.com)
Envenomation9
- Acute renal failure is a common complication caused by Bothrops viper envenomation. (sigmaaldrich.com)
- Myotoxic phospholipases A 2 (PLA 2 ) are responsible for many clinical manifestations in envenomation by Bothrops snakes. (mdpi.com)
- Effect of light emitting diode photobiomodulation on murine macrophage function after Bothrops envenomation. (bvsalud.org)
- In conclusion, this study showed that LED treatment has the potential to be used in combination with conventional serum therapy to prevent or minimize the progression of local to severe symptoms after Bothrops envenomation. (bvsalud.org)
- The mechanism of consumption coagulopathy observed in cases of human envenomation by Bothrops jararaca is well established. (bvsalud.org)
- Envenomation by Bothrops species results, among other symptoms, in hemostatic disturbances. (unesp.br)
- Experimental Bothrops jararaca (Bj) envenomation can provoke marked morphological alterations in the antimesometrial (AM) region of uterus in pregnant mice which can culminate in the end of gestation. (unifesp.br)
- This investigation aimed to verify whether Bothrops antivenom (BAV) could restore the normal morphology of murine uterus, after Bj envenomation. (unifesp.br)
- Envenomation by Bothrops snakes cause local damage as well as systemic, hemostatic and cardiovascular effects. (butantan.gov.br)
Species19
- Found in northeastern Mexico (Tamaulipas) southward through Central and South America to Argentina, Bothrops species also occur on the islands of Saint Lucia and Martinique in the Lesser Antilles, as well as on Ilha da Queimada Grande off the coast of Brazil. (wikipedia.org)
- This species, unlike most Bothrops, preys primarily on birds, due to the absence of native mammal species on Queimada Grande. (wikipedia.org)
- Many species of Bothrops exhibit tail vibration behavior when disturbed. (wikipedia.org)
- Bothrops insularis, commonly known as the golden lancehead, is a highly venomous pit viper species endemic to Ilha da Queimada Grande, off the coast of São Paulo state, in Brazil. (wikipedia.org)
- Ferrarezzi, H. & Freire, E.M.X. (2001) New species of Bothrops Wagler, 1824 from the Atlantic forest of northeastern Brazil (Serpentes, Viperidae, Crotalinae). (gbif.org)
- As part of this project we are currently working on a systematic revision of the Bothrops-complex in Peru (11 + 2 new species). (zfmk.de)
- Additionally, the morphological variability in the Bothrops neuwiedii species group will be examined, with special respect to the widely distributed B. diporus. (zfmk.de)
- Synonymy: Note that Amaral described Bothrops iglesiasi as a new species in two independent papers, published in 1923 and 1926. (reptarium.cz)
- Origin and phylogenetic position of the Lesser Antillean species of Bothrops (Serpentes, Viperidae): biogeographical and medical implications. (ajtmh.org)
- Proteolytic activity of the venom on renal glomeruli could then contribute to the onset of acute renal failure, and would explain the clinical manifestations of renal injury after bites by this and other Bothrops species. (ajtmh.org)
- 7 ], has inspired other studies with other species of Bothrops . (biomedcentral.com)
- Bothrops punctatus is an endangered, semi-arboreal pitviper species distributed in Panamá, Colombia, and Ecuador, whose venom is poorly characterized. (peerj.com)
- In this work, we used a transcriptomic approach to examine the venom gland genes of Bothrops alternatus , a clinically important species found in southeastern and southern Brazil, Uruguay, northern Argentina and eastern Paraguay. (biomedcentral.com)
- The lack of basic PLA 2 agrees with the lower myotoxicity of this venom compared to other Bothrops species with these toxins. (biomedcentral.com)
- Detailed transcriptomic studies of snake venom glands began with the report of Junqueira-de-Azevedo and Ho [ 13 ] who analyzed expressed sequence tags (ESTs) from the venom gland of the Brazilian pitviper Bothrops insularis , a species endemic to the island of Queimada Grande off the coast of the State of São Paulo in southeastern Brazil. (biomedcentral.com)
- The effect of the three main Brazilian polyspecific antivenoms on venom clearance was assessed in 118 moderately envenomed victims of bites by Bothrops species (mainly B. jararaca) in Sao Paulo State, Brazil. (ox.ac.uk)
- However, many scientists now restrict the name 'fer-de-lance' to the Martinican species, Bothrops lanceolatus. (ypte.org.uk)
- Like other pit vipers Bothrops species have two indentations or 'pits' behind and above the nostrils which can detect a rise or drop in temperature of just 0.001°C, allowing it to detect warm-blooded mammals. (ypte.org.uk)
- Bothrops species are able to climb and swim. (ypte.org.uk)
Atrox3
- Three horse-derived antivenoms were tested for their ability to neutralize lethal, hemorrhagic, edema-forming, defibrinating and myotoxic activities induced by the venom of Bothrops atrox from Antioquia and Chocó (Colombia). (scielo.br)
- The batroxobin from the snake Bothrops atrox is patented as Reptilase and used as a hemostatic drug. (creative-enzymes.com)
- Bothrops atrox is responsible for the majority of snakebite accidents in the Brazilian Amazon region. (biomedcentral.com)
Alternatus2
- El objetivo del presente trabajo fue estudiar la histología de las glándulas cefálicas de la víbora de la cruz ( Bothrops alternatus), identificar los tipos celulares y caracterizar histoquimicamente el producto de secreción. (bvsalud.org)
- Alternagin-C (ALT-C), a disintegrin-like protein from the venom of Bothrops alternatus induces in vivo angiogenesis as well as the cyclic peptide derived from its primary structure, with the ECD motif (ALT-C PEP). (ufscar.br)
Moojeni snake venom4
- Bothrops moojeni snake venom-induced renal glomeruli changes in rat. (ajtmh.org)
- Herein, we isolated and characterized Moojase, a potent coagulant enzyme from Bothrops moojeni snake venom. (bioinfor.com)
- Here we addressed whether MjTX-I, a phospholipase A 2 isolated from Bothrops moojeni snake venom, affects the viability of imatinib mesylate-resistant Bcr-Abl + cell lines. (biomedcentral.com)
- The MjTX-I isolated from Bothrops moojeni snake venom ( B. moojeni myotoxin I) is genotoxic to human lymphocyte DNA. (biomedcentral.com)
Snakes4
- In this study, we performed genetic analysis of the opsin genes and morphological analysis of the photoreceptors of two snakes from the Viperidae family, Bothrops jararaca and Crotalus durissus terrificus. (usp.br)
- In order to monitor and investigate the high number of atretic eggs released by captive Bothrops snakes, we investigated possible apoptotic cell death studing cell cycle as a molecular approaches. (who.int)
- Different cell cycle phases were identified in the embryos of captive Bothrops snakes. (who.int)
- Hemorrhage, intravascular coagulation and cardiovascular shock are effects commonly observed in victims bitten by Bothrops snakes. (ke-i.org)
Serpentes3
- RONALD L. GUTBERLET JR, JENNAFER A. EVANS, CHRISTOPHER L. PARKINSON (2009) Morphological and molecular evidence for phylogeny and classification of South American pitvipers, genera Bothrops, Bothriopsis, and Bothrocophias (Serpentes: Viperidae). (gbif.org)
- Neste trabalho foi realizada a análise dos genes de fotopigmentos visuais e da morfologia dos fotorreceptores de duas espécies de serpentes da família Viperidae, Bothrops jararaca e Crotalus durissus terrificus. (usp.br)
- Morphological and molecular evidence for phylogeny and classification of South American pitvipers, genera Bothrops, Bothriopsis, and Bothrocophias Serpentes: If no motor vehicle jaarracussu boat is available, the patient can be carried on a stretcher or hurdle, on the pillion or crossbar of a bicycle or on someone's back. (argentinamotoadventure.com)
Asper venom3
- A new myotoxic acidic Asp49 PLA 2 (BaCol PLA 2 ) was isolated from Colombian Bothrops asper venom using reverse-phase high performance liquid chromatography (RP-HPLC). (mdpi.com)
- Bothrops asper venom-induced hyperalgesia was blocked by the bradykinin B2 receptor antagonist HOE 140 and attenuated by dexamethasone, an inhibitor of phospholipase A2. (ucr.ac.cr)
- Pathogenesis of the myonecrotic, hemorrhagic and edema-forming effects in white mice inoculated with Bothrops asper venom was studied at different time intervals by means of light microscopy, determination of serum levels of the enzyme creatinephosphokinase (CPK), and evaluation of edema. (ucr.ac.cr)
Jararacussu venom4
- Thus, the aim of the present study was to verify the capability of Casearia gossypiosperma hydroalcoholic extract to neutralize the neuromuscular blockade induced by Bothrops jararacussu venom. (scielo.br)
- The crystal structure of an acidic phospholipase A(2) isolated from Bothrops jararacussu venom (BthA-I) chemically modified with p-bromophenacyl bromide (BPB) has been determined at 1.85 Angstroms resolution. (rcsb.org)
- The anti-snake venom activity was measured by Vf's ability to neutralize the in vitro neuromuscular blockade caused by Bothrops jararacussu venom (Bjssu) in a mouse phrenic nerve-diaphragm model (PND). (biomedcentral.com)
- Several sesquiterpene lactone were synthesized and their inhibitive activities on phospholipase A2 (PLA2) from Bothrops jararacussu venom were evaluated. (unicamp.br)
Crotalus5
- A ação de fosfolipases A 2 (FLA 2 s): miotoxinas (MTs) ?II e III, isoladas de Bothrops asper (VBa) e CB2, de Crotalus durissus terrificus (VCdt) e os venenos brutos, sobre a expressão de ciclooxigenases (COXs) e síntese de prostaglandina (PG) E 2 e PGD 2 foi avaliada. (usp.br)
- The neotropical pitvipers Crotalus durissus and Bothrops jararaca show a sazonal reproductive cycle with an active stage of follicular development (vitellogenesis Type II) in late austral autumn and winter. (openthesis.org)
- Males of Bothrops and Crotalus show two elongated testes which communicate bilaterally with the cloaca through the coiled deferent ducts. (openthesis.org)
- Effects of polyspecific Bthrops antivenom were not impressive, and it has been suggested that anti-Bothrops and anti-Crotalus antivenoms should be given in combination. (argentinamotoadventure.com)
- These are Crotalus Horridus and Bothrops. (hubpages.com)
Myotoxin3
- Recent studies on site directed mutagenesis of the recombinant Lys49 myotoxin from Bothrops jararacussu revealed the participation of important amino acid residues in the membrane damaging and myotoxic activities. (eurekaselect.com)
- The binding of Bothrops asper myotoxin to mouse skeletal muscle was studied at both the light and electron microscope levels using the peroxidase anti-peroxidase technique. (ucr.ac.cr)
- This study evaluated the influence of molecular weight on the ability of fucoidan to prevent muscle necrosis when rapidly administered after injection of a purified myotoxin or crude venom of Bothrops asper, in a mouse model. (nih.gov)
Antivenom3
- In vivo myotoxic effects and in vitro irreversible neuromuscular blockade effects of crude venom from the snake Bothrops jararacussu are well known pharmacological methods used to study drugs showing antivenom properties (29, 30). (scielo.br)
- Prevention of thromboses in human patients with Bothrops lanceolatus envenoming in Martinique: failure of anticoagulants and efficacy of a monospecific antivenom. (ajtmh.org)
- Rutin, a flavonoid, may complement antivenom as an effective co-treatment for envenoming from Bothrops jaraca. (eurekalert.org)
Insularis7
- No subspecies of Bothrops insularis are currently recognized. (wikipedia.org)
- Sexually mature Bothrops insularis mate during August and September, and have been known to mate both in the trees and on the ground. (wikipedia.org)
- Bothrops insularis can usually be found either in the trees hunting for its prey, or seeking shelter among leaf litter or in rock crevices, especially during unfavorable weather or after having just ingested its prey. (wikipedia.org)
- The svVEGF-F was identified during the generation of abundant expressed sequence tags from the Viperidae snake Bothrops insularis venom glands. (reliatech.de)
- The present paper reports this condition in an 18-year-old captive golden lancehead ( Bothrops insularis ) from Brazil. (usp.br)
- Molecular identification and phylogenetic analysis of Bothrops insularis bacterial and fungal microbiota. (usp.br)
- During the generation of Expressed Sequence Tags (ESTs) from the venom glands of the Viperidae snake Bothrops insularis, we identified a cDNA coding for a putative Ca 2+ binding protein with four EF-hand motifs, named here calglandulin. (elsevier.com)
Lanceolatus5
- Clinical indicators of envenoming and serum levels of venom antigens in patients bitten by Bothrops lanceolatus in Martinique. (ajtmh.org)
- Prognostic significance of clinical grading of patients envenomed by Bothrops lanceolatus in Martinique. (ajtmh.org)
- Bothrops lanceolatus snake venom causes systemic thrombotic syndrome but also local inflammation involving extensive oedema, pain, and haemorrhage. (cf.ac.uk)
- Repositorio da Producao Cientifica e Intelectual da Unicamp: Neuromuscular Action Of Bothrops Lanceolatus (fer De Lance) Venom And A Caseinolytic Fraction. (unicamp.br)
- A protein capable of inducing neuromuscular blockade in avian preparations and of depolarizing mouse diaphragm muscle was isolated from Bothrops lanceolatus venom using gel filtration and ion-exchange chromatography. (unicamp.br)
Veneno de la serpiente peruana1
- Se ha aislado una enzima proteolítica del veneno de la serpiente peruana Bothrops brazili, por cromatografía en Sephadex G-100 y CM-Sephadex C-50, con buffer acetato de amonio 0,05M pH 7,0. (wroc.pl)
Pitviper2
- 2015. Bothrops diporus (southern pitviper) diet / ophiophagy. (reptarium.cz)
- The Chocoan forest lancehead, Bothrops punctatus , known in Colombia as 'rabo de chucha', is a large semi-arboreal pitviper, ranging from 1.0 to 1.5 m in length. (peerj.com)
Snakebite2
- Snakebite envenoming by Bothrops caribbaeus, an endemic viperid from the Lesser Antillean island of Saint Lucia, is clinically characterized by local tissue damage and systemic thrombosis that can lead to cerebral, myocardial or pulmonary infarctions and venous thromboses. (ox.ac.uk)
- Bothrops moojeni is an abundant venomous snake responsible for most of the snakebite cases in the Central region of Brazil and as a result of the anthropogenic habitat disturbance, such as the increase in extensive farming, the range of B. moojeni has been greatly fragmented. (geneticsmr.com)
Isolated from the venom3
- We evaluated the antiviral action of Mt-I (catalytically-active sPLA2) and Mt-II (catalytically-inactive variant) isolated from the venom of Bothrops asper, against a diverse group of viruses. (medworm.com)
- The medicine Defibrase is the trade name given to batroxobin and is isolated from the venom of Bothrops moojeni. (creative-enzymes.com)
- The ability of the P-I metalloproteinase BaP1, isolated from the venom of the snake Bothrops asper, to induce systemic bleeding, thrombocytopenia and defibrinogenation was assessed in an experimental mouse model. (lstmed.ac.uk)
Hoge1
- Hoge,A.R. (1954) A new Bothrops from Brazil - Bothrops brazili, sp. (gbif.org)
Bjssu3
- The pharmacological activity of C. gossypiosperma (Cg) hydroalcoholic extract was assayed by a traditional in vitro test, which involved irreversible neuromuscular blockade induced by Bothrops jararacussu (Bjssu) venom (60 µ g/mL) in mouse phrenic nerve-diaphragm preparations. (scielo.br)
- These extracts were evaluated against the myotoxicity (58%) and the irreversible in vitro neuromuscular blockade of Bothrops jararacussu (Bjssu) venom (40µg/ml) in a mouse phrenic-nerve diaphragm preparation, by using light-microscopy and conventional myographic techniques. (libpubmedia.co.uk)
- The crude venom of Bothrops jararacussu (Bjssu) is known to induce muscular paralysis in vitro. (bvs-vet.org.br)
Venenos1
- Venenos do gênero Bothrops causam, além de efeitos locais, efeitos sistêmicos sobre os sistemas hemostático e cardiovascular. (butantan.gov.br)
Characterization1
- Here we describe for the first time the isolation and functional characterization of a soluble phosphodiesterase from Bothrops jararaca venom, which shows amino acid sequence similarity to mammalian nucleotide pyrophosphatase/phosphodiesterase 3 (NPP3), and inhibits ADP-induced platelet aggregation. (sigmaaldrich.com)
Toxin1
- Relative abundance of the major toxin families in Bothrops venom gland transcriptomes. (biomedcentral.com)
Systemic2
- Moderate and severe envenomations by the snake Bothrops asper provoke systemic alterations, such as systemic bleeding, coagulopathy, hypovolemia, hemodynamic instability and shock, and acute renal failure. (ucr.ac.cr)
- Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model. (ox.ac.uk)
Reptile Database1
- The American Naturalist 188.4 (2016): 475-483 Bothrops at the Reptarium.cz Reptile Database. (wikipedia.org)
Myotoxins3
- Role of enzymatic activity in muscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved? (peerj.com)
- Mora-Obando D, Díaz C, Angulo Y, Gutiérrez JM, Lomonte B. ( 2014 ) Role of enzymatic activity in muscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A 2 myotoxins: are there additional effector mechanisms involved? (peerj.com)
- The neutralization of two myotoxic phospholipases A2 from the venom of Bothrops asper, myotoxins I and II, by two murine monoclonal antibodies is reported. (ucr.ac.cr)
Brazili2
- Se ha purificado y caracterizado parcialmente la L-aminoácido oxidasa de la serpiente Bothrops brazili. (doaj.org)
- A proteolitic enzyme was purified from Bothrops brazili peruvian snake venom using Sephadex G-100 followed by CM-Sephadex C-50, in both two cases with 0.05M ammonium acetate pH 7,0. (wroc.pl)
Brazil3
- Snake bites by the jararacucu (Bothrops jararacussu): Clinicopathological studies of 29 proven cases in Sao Paulo State, Brazil. (argentinamotoadventure.com)
- Belonging to the Viperidae family, Bothrops moojeni are widely distributed in South America, tropical savanna ecoregion (Cerrado) of Argentina, Bolivia, Brazil, and Paraguay with medical importance in Brazil. (jvenomres.co.uk)
- Bothrops marajoensis is found in the savannah of Marajo Island in the State of Par S and regions of Amapa State, Brazil. (unesp.br)
Neuromuscular1
- This study describe s the effects of Bothrops marajoensis venom (Marajó lancehead) on isolated neuromuscular preparations of chick biventer cervicis (CBC) and mouse phrenic nerve-diaphragm (PND). (libpubmedia.co.uk)
Snake venom metalloproteinase1
- Jararhagin, a hemorrhagic snake venom metalloproteinase from Bothrops jararaca. (biomedsearch.com)
PLA22
- MP-III 4R PLA2 was purified from the venom of Bothrops pirajai venom (Bahia's jararacussu) after three chromatographic steps which started with RP-HPLC. (eurekamag.com)
- The complete amino acid sequence of MP-III 4R PLA2 from Bothrops pirajai was determined by amino acid sequencing of reduced and carboxymethylated MP-III 4R and the isolated peptides from clostripain and protease V8 digestion. (eurekamag.com)
19661
- 1966). In this communication we describe the isolation of nine biologically active peptides from Bothrops jararaca venom, present the amino acid sequence determination of the smallest of the active peptides, PCA-Lys-Trp-Ala-Pro, and describe the synthesis of this peptide by the solid phase method. (springer.com)
Amaral1
- Bothrops neuwiedi bolivianus Amaral. (reptarium.cz)
Platelet aggregation1
- NPP-BJ, a nucleotide pyrophosphatase/phosphodiesterase from Bothrops jararaca snake venom, inhibits platelet aggregation. (sigmaaldrich.com)
Envenomations1
- In Central America, the majority of human envenomations due to snakebites are inflicted by Bothrops aspe r, commonly known as "ter-ciopelo" or "barba amarilla" ( Gutiérrez 1995, 2002 ). (scielo.sa.cr)
Protein1
- 2014). Interaction of Bothrops jararaca venom metalloproteinases with protein inhibitors. (ke-i.org)
Crude1
- From the crude snake venom of Bothrops moojeni, a homodimeric lectin was purified by affinity chromatography in lactose and was named BMooL. (unicamp.br)