Bothrops: A genus of poisonous snakes of the VIPERIDAE family. About 50 species are known and all are found in tropical America and southern South America. Bothrops atrox is the fer-de-lance and B. jararaca is the jararaca. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p336)Crotalid Venoms: Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.Antivenins: Antisera used to counteract poisoning by animal VENOMS, especially SNAKE VENOMS.Reptilian Proteins: Proteins obtained from species of REPTILES.Snake Bites: Bites by snakes. Bite by a venomous snake is characterized by stinging pain at the wound puncture. The venom injected at the site of the bite is capable of producing a deleterious effect on the blood or on the nervous system. (Webster's 3d ed; from Dorland, 27th ed, at snake, venomous)Snake Venoms: Solutions or mixtures of toxic and nontoxic substances elaborated by snake (Ophidia) salivary glands for the purpose of killing prey or disabling predators and delivered by grooved or hollow fangs. They usually contain enzymes, toxins, and other factors.Group II Phospholipases A2: A subcategory of secreted phospholipases A2 that includes enzymes isolated from a variety of sources. The creation of this group is based upon similarities in the structural determinants of the enzymes including a negatively charged carboxy-terminal segment.L-Amino Acid Oxidase: An enzyme that catalyzes the oxidative deamination of L-amino acids to KETO ACIDS with the generation of AMMONIA and HYDROGEN PEROXIDE. L-amino acid oxidase is widely distributed in and is thought to contribute to the toxicity of SNAKE VENOMS.Eclipta: A plant genus of the family ASTERACEAE. Members contain wedelolactone.Batroxobin: A proteolytic enzyme obtained from the venom of fer-de-lance (Bothrops atrox). It is used as a plasma clotting agent for fibrinogen and for the detection of fibrinogen degradation products. The presence of heparin does not interfere with the clotting test. Hemocoagulase is a mixture containing batroxobin and factor X activator. EC 3.4.21.-.Snakes: Limbless REPTILES of the suborder Serpentes.Crotalus: A genus of snakes of the family VIPERIDAE, one of the pit vipers, so-called from the pit hollowing out the maxillary bone, opening between the eye and the nostril. They are distinctively American serpents. Most of the 25 recognized species are found in the southwestern United States and northern Mexico. Several species are found as far north as Canada and east of the Mississippi, including southern Appalachia. They are named for the jointed rattle (Greek krotalon) at the tip of their tail. (Goin, Goin, and Zug: Introduction to Herpetology, 3d ed; Moore: Poisonous Snakes of the World, 1980, p335)Viperidae: A family of snakes comprising three subfamilies: Azemiopinae (the mountain viper, the sole member of this subfamily), Viperinae (true vipers), and Crotalinae (pit vipers). They are widespread throughout the world, being found in the United States, Central and South America, Europe, Asia and Africa. Their venoms act on the blood (hemotoxic) as compared to the venom of elapids which act on the nervous system (neurotoxic). (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, pp333-36)Coagulants: Agents that cause clotting.Phospholipases A2: Phospholipases that hydrolyze the acyl group attached to the 2-position of PHOSPHOGLYCERIDES.Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.Viper Venoms: Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.Pentacyclic Triterpenes: Five-ring derivatives of dammarane having a chair-chair-chair-boat configuration. They include the lupanes, oleananes, amyrins, GLYCYRRHIZIC ACID, and soyasaponins.Neurogenic Inflammation: Inflammation caused by an injurious stimulus of peripheral neurons and resulting in release of neuropeptides which affect vascular permeability and help initiate proinflammatory and immune reactions at the site of injury.Access to Information: Individual's rights to obtain and use information collected or generated by others.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Alice in Wonderland Syndrome: Neurological condition characterized by disturbances in VISUAL PERCEPTION, most often of BODY SCHEMA, TIME PERCEPTION and HALLUCINATIONS. It is associated with MIGRAINE, infections (e.g., INFECTIOUS MONONUCLEOSIS), FEVER, EPILEPSY, and other neurological and psychiatric disorders.Hawks: Common name for many members of the FALCONIFORMES order, family Accipitridae, generally smaller than EAGLES, and containing short, rounded wings and a long tail.JapanMelanesia: The collective name for the islands of the Pacific Ocean northeast of Australia, including NEW CALEDONIA; VANUATU; New Hebrides, Solomon Islands, Admiralty Islands, Bismarck Archipelago, FIJI, etc. Melanesia (from the Greek melas, black + nesos, island) is so called from the black color of the natives who are generally considered to be descended originally from the Negroid Papuans and the Polynesians or Malays. (From Webster's New Geographical Dictionary, 1988, p748 & Room, Brewer's Dictionary of Names, 1992, p344)Atlantic Islands: Widely scattered islands in the Atlantic Ocean as far north as the AZORES and as far south as the South Sandwich Islands, with the greatest concentration found in the CARIBBEAN REGION. They include Annobon Island, Ascension, Canary Islands, Falkland Islands, Fernando Po (also called Isla de Bioko and Bioko), Gough Island, Madeira, Sao Tome and Principe, Saint Helena, and Tristan da Cunha.Pyrophosphatases: A group of enzymes within the class EC 3.6.1.- that catalyze the hydrolysis of diphosphate bonds, chiefly in nucleoside di- and triphosphates. They may liberate either a mono- or diphosphate. EC 3.6.1.-.Phosphoric Diester Hydrolases: A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.Phosphodiesterase I: A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis.Materia Medica: Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.Martinique: An island in the Lesser Antilles, one of the Windward Islands. Its capital is Fort-de-France. It was discovered by Columbus in 1502 and from its settlement in 1635 by the French it passed into and out of Dutch and British hands. It was made a French overseas department in 1946. One account of the name tells of native women on the shore calling "Madinina" as Columbus approached the island. The meaning was never discovered but was entered on early charts as Martinique, influenced by the name of St. Martin. (From Webster's New Geographical Dictionary, 1988, p734 & Room, Brewer's Dictionary of Names, 1992, p339)Osmeriformes: An order of fish including smelts, galaxiids, and salamanderfish.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Paroxysmal Hemicrania: A primary headache disorder that is similar to the CLUSTER HEADACHE with unilateral head pain, but differs by its multiple short severe attacks. It is usually seen in females, and may be responsive to non-steroidal-anti-inflammatory drugs (NSAIDS).Costa RicaChromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Creatine Kinase: A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.Phospholipases A: Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates.Gilbert Disease: A benign familial disorder, transmitted as an autosomal dominant trait. It is characterized by low-grade chronic hyperbilirubinemia with considerable daily fluctuations of the bilirubin level.Transglutaminases: Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.ColombiaIctaluridae: A family of North American freshwater CATFISHES. It consists of four genera (Ameiurus, Ictalurus, Noturus, Pylodictis,) comprising several species, two of which are eyeless.D-Amino-Acid OxidaseCharaciformes: An order of fresh water fish with 18 families and over 1600 species. The order includes CHARACINS, hatchetfish, piranhas, and TETRAS.Bee Venoms: Venoms obtained from Apis mellifera (honey bee) and related species. They contain various enzymes, polypeptide toxins, and other substances, some of which are allergenic or immunogenic or both. These venoms were formerly used in rheumatism to stimulate the pituitary-adrenal system.Venoms: Poisonous animal secretions forming fluid mixtures of many different enzymes, toxins, and other substances. These substances are produced in specialized glands and secreted through specialized delivery systems (nematocysts, spines, fangs, etc.) for disabling prey or predator.Atrial Flutter: Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).o-Chlorobenzylidenemalonitrile: A riot control agent which causes temporary irritation of the eyes and the mucosal surface of the respiratory tract. It is a more potent irritant than OMEGA-CHLOROACETOPHENONE, but less incapacitating.Ancrod: An enzyme fraction from the venom of the Malayan pit viper, Agkistrodon rhodostoma. It catalyzes the hydrolysis of a number of amino acid esters and a limited proteolysis of fibrinogen. It is used clinically to produce controlled defibrination in patients requiring anticoagulant therapy. EC 3.4.21.-.Agkistrodon: A genus of venomous snakes of the subfamily Crotalinae. Twelve species of this genus are found in North and Central America and Asia. Agkistrodon contortrix is the copperhead, A. piscivorus, the cottonmouth. The former is named for its russet or orange-brown color, the latter for the white interior of its mouth. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p336; Moore, Poisonous Snakes of the World, 1980, p75)

Sequential randomised and double blind trial of promethazine prophylaxis against early anaphylactic reactions to antivenom for bothrops snake bites. (1/183)

OBJECTIVE: To investigate the efficacy of the H1 antihistamine promethazine against early anaphylactic reactions to antivenom. DESIGN: Sequential randomised, double blind, placebo controlled trial. SETTING: Public hospital in a venom research institute, Sao Paulo, Brazil. PARTICIPANTS: 101 patients requiring antivenom treatment after being bitten by bothrops snakes. INTERVENTION: Intramuscular injection of promethazine (25 mg for adults and 0.5/kg for children) or placebo given 15-20 min before starting intravenous infusion of antivenom. MAIN OUTCOME MEASURES: Incidence and severity of anaphylactic reactions occurring within 24 hours after antivenom. RESULTS: Reactions occurred in 12 of 49 patients treated with promethazine (24%) and in 13 of 52 given placebo (25%); most were mild or moderate. Continuous sequential analysis indicated that the study could be interrupted at the 22nd untied pair, without preference for promethazine or placebo. CONCLUSION: Prophylaxis with promethazine does not prevent early reactions. Patients should be observed carefully during antivenom infusion and the subsequent few hours.  (+info)

Crystallization and preliminary X-ray diffraction analysis of a myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom. (2/183)

Crystals of a myotoxic phospholipase A(2) from Bothrops neuwiedi pauloensis have been obtained. They diffracted at 2.5 A resolution using a synchrotron radiation source and belong to space group P3(1)21. Preliminary analysis shows that there are two molecules in the asymmetric unit.  (+info)

"RKKH" peptides from the snake venom metalloproteinase of Bothrops jararaca bind near the metal ion-dependent adhesion site of the human integrin alpha(2) I-domain. (3/183)

Integrin alpha(1)beta(1) and alpha(2)beta(1) are the major cellular receptors for collagen, and collagens bind to these integrins at the inserted I-domain in their alpha subunit. We have previously shown that a cyclic peptide derived from the metalloproteinase domain of the snake venom protein jararhagin blocks the collagen-binding function of the alpha(2) I-domain. Here, we have optimized the structure of the peptide and identified the site where the peptide binds to the alpha(2) I-domain. The peptide sequence Arg-Lys-Lys-His is critical for recognition by the I-domain, and five negatively charged residues surrounding the "metal ion-dependent adhesion site" (MIDAS) of the I-domain, when mutated, show significantly impaired binding of the peptide. Removal of helix alphaC, located along one side of the MIDAS and suggested to be involved in collagen-binding in these I-domains, does not affect peptide binding. This study supports the notion that the metalloproteinase initially binds to the alpha(2) I-domain at a location distant from the active site of the protease, thus blocking collagen binding to the adhesion molecule in the vicinity of the MIDAS, while at the same time leaving the active site free to degrade nearby proteins, the closest being the beta(1) subunit of the alpha(2)beta(1) cell-surface integrin itself.  (+info)

Histologic and functional renal alterations caused by Bothrops moojeni snake venom in rats. (4/183)

Acute renal failure (ARF) is the main cause of death following snake bites by Bothrops species. In this study, we investigated the morphologic and functional renal disturbances caused by Bothrops moojeni venom in rats. Renal function was assessed based on creatinine and lithium clearances and on histologic examination of renal tissue 5 hr after the intravenous administration of 0.2 mg of venom/kg and 5 hr, 16 hr, and 48 hr after 0.4 mg of venom/ kg. A venom dose of 0.4 mg/kg produced renal tubule disturbances, including acute impairment of proximal and post-proximal tubule sodium handling associated with acute tubule necrosis. The glomerular filtration rate (GFR) decreased significantly and was accompanied by severe morphologic disturbances in the renal glomeruli. These functional and morphologic findings were observed in the absence of any change in mean arterial blood pressure. The decrease in GFR was not related to the presence of fibrin deposits in the glomerular capillary loops. These results suggest an early nephrotoxic action of B. moojeni venom involving significant morphologic and functional changes similar to those observed in snakebite-induced ARF in humans.  (+info)

Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties. (5/183)

Myotoxic phospholipases A(2) (PLA(2)s; group II) account for most of the muscle-tissue damage that results from envenomation by viperid snakes. In the venom of the Godman's viper (Cerrophidion godmani, formerly Bothrops godmani), an enzymically active PLA(2) (myotoxin I) and an inactive, Lys-49 variant (myotoxin II) induce extensive muscle damage and oedema. In this study, two distinct myotoxin inhibitor proteins of C. godmani, CgMIP-I and CgMIP-II, were purified directly from blood plasma by selective binding to affinity columns containing either myotoxin I or myotoxin II, respectively. Both proteins are glycosylated, acidic (pI=4) and composed of 20-25-kDa subunits that form oligomers of 110 kDa (CgMIP-I) or 180 kDa (CgMIP-II). In inhibition studies, CgMIP-I specifically neutralized the PLA(2) and the myotoxic, oedema-forming and cytolytic activities of myotoxins I, whereas CgMIP-II selectively inhibited the toxic properties of myotoxin II. N-terminal amino acid sequence analysis and sequencing of cDNAs encoding the two inhibitors revealed that CgMIP-I is similar to gamma-type inhibitors, which share a pattern of cysteine residues present in the Ly-6 superfamily of proteins, whereas CgMIP-II shares sequence identity with alpha-type inhibitors that contain carbohydrate-recognition-like domains, also found in C-type lectins and mammalian PLA(2) receptors. N-terminal sequencing of myotoxin I revealed a different primary structure from myotoxin II [De Sousa, Morhy, Arni, Ward, Diaz and Gutierrez (1998) Biochim. Biophys. Acta 1384, 204-208], which provides insight into the nature of such pharmacological specificity.  (+info)

Antibody from mice immunized with DNA encoding the carboxyl-disintegrin and cysteine-rich domain (JD9) of the haemorrhagic metalloprotease, Jararhagin, inhibits the main lethal component of viper venom. (6/183)

Envenoming by the Brazilian pit viper, Bothrops jararaca, induces extensive local and systemic haemorrhage in humans. The severe and occasionally lethal outcome of envenoming is prevented only by administration of antivenom which is conventionally prepared by hyperimmunization of large animals with an individual venom or a range of venoms. Since snake venoms typically consist of numerous molecules, only some of which are toxic, antivenoms are antigenically crude preparations whose therapeutic value would theoretically be enhanced by restricting antibody specificity to toxic venom molecules. We report here that high-titre IgG antibody from mice immunized by the GeneGun with DNA encoding the carboxy-terminal JD9 domain of Jararhagin, a haemorrhage-inducing metalloprotease in B. jararaca venom, extensively neutralized the main lethal component of B. jararaca venom. This is to our knowledge the first study to apply DNA-based methods to preparation of antivenom; it represents a novel approach with greater immunological specificity and fewer hazards than conventional systems of antivenom production.  (+info)

Basic residues of human group IIA phospholipase A2 are important for binding to factor Xa and prothrombinase inhibition comparison with other mammalian secreted phospholipases A2. (7/183)

Human secreted group IIA phospholipase A2 (hGIIA) was reported to inhibit prothrombinase activity because of binding to factor Xa. This study further shows that hGIIA and its catalytically inactive H48Q mutant prolong the lag time of thrombin generation in human platelet-rich plasma with similar efficiency, indicating that hGIIA exerts an anticoagulant effect independently of phospholipid hydrolysis under ex vivo conditions. Charge reversal of basic residues on the interfacial binding surface (IBS) of hGIIA leads to decreased ability to inhibit prothrombinase activity, which correlates with a reduced affinity for factor Xa, as determined by surface plasmon resonance. Mutation of other surface-exposed basic residues, hydrophobic residues on the IBS, and His48, does not affect the ability of hGIIA to inhibit prothrombinase activity and bind to factor Xa. Other basic, but not neutral or acidic, mammalian secreted phospholipases A2 (sPLA2s) exert a phospholipid-independent inhibitory effect on prothrombinase activity, suggesting that these basic sPLA2s also bind to factor Xa. In conclusion, this study demonstrates that the anticoagulant effect of hGIIA is independent of phospholipid hydrolysis and is based on its interaction with factor Xa, leading to prothrombinase inhibition, even under ex vivo conditions. This study also shows that such an interaction involves basic residues located on the IBS of hGIIA, and suggests that other basic mammalian sPLA2s may also inhibit blood coagulation by a similar mechanism to that described for hGIIA.  (+info)

Local haemorrhage induced by Bothrops jararaca venom: relationship to neurogenic inflammation. (8/183)

We investigated morphological alterations induced by s.c. injection of 2.5 microg of Bothrops jararaca venom in rats. Intense disorganisation of collagen fibres was observed 1 min after the venom injection, particularly at regions near vessels and nerves. Mast cells were degranulated, and erythrocytes were seen leaving venules throughout the endothelial junctions. At this time, damaged endothelial cells were not observed. In rats envenomed as above, but immediately after cardiorespiratory failure induced by deep ether anaesthesia, alterations in the connective tissue structures, as previously described, were not observed. The mediation of this haemorrhage was investigated by injecting the venom into the foot pad of mice and compared to the mediation of oedema. Local haemorrhage was significantly reduced in mice pre-treated with capsaicin or guanethidine or submitted to a surgical section of sciatic and saphenous nerves. In these animals, oedema was not affected. Groups treated with methysergide or morphine showed both haemorrhage and oedema significantly reduced. Indomethacin or dexamethasone pre-treatments significantly reduced the oedema, but not the haemorrhage. Moreover, in animals treated with promethazine or mepyramine, oedema and haemorrhage were not affected. These data suggest that local haemorrhage induced by Bothrops jararaca venom is partially controlled by serotonin and neurohumoral mediators. Furthermore, results indicate that haemorrhage and oedema are mediated by different pharmacological systems.  (+info)

*Erpetogomphus

Paulson, D. R. (2009). "Erpetogomphus bothrops". The IUCN Red List of Threatened Species. IUCN. 2009: e.T165051A5975649. doi: ... 1859 Erpetogomphus bothrops Garrison, 1994 - one-striped ringtail Erpetogomphus compositus Hagen in Selys, 1858 - white-belted ...

*Bothriechis rowleyi

Bothrops rowleyi, new species). Bothriechis rowleyi at the Reptarium.cz Reptile Database. Accessed 14 September 2007.. ... Bogert CM (1968). "A New Arboreal Pit Viper of the Genus Bothrops from the Isthmus of Tehuantepec, Mexico". American Museum ...

*Cerrophidion tzotzilorum

Bothrops tzotzilorum, new species). Cerrophidion tzotzilorum at the Reptarium.cz Reptile Database. Accessed 14 September 2007. ... Campbell JA (1985). "A New Species of Highland Pitviper of the Genus Bothrops from Southern Mexico". Journal of Herpetology 19 ...

*Clodoveo Carrión Mora

Reptiles: Atractus carrioni Parker, 1930; Bothrops lojanus Parker, 1930; Stenocercus carrioni Parker, 1934. Arthropods: ...

*Snake venom

The chicken snake (Spilotes pullatus) is the enemy of the Fer-de-Lance (Bothrops caribbaeus) in St. Lucia, and it is said[by ... In Brazil, serum prepared with the venom of lanceheads (Bothrops spp.) is without action on rattlesnake (Crotalus spp.) venom. ... Bothrops spp.); and the African adders (Bitis spp.), night adders (Causus spp.), and horned vipers (Cerastes spp.), cause fatal ...

*Trimeresurus hageni

"Bothrops Hageni", pp. 53-54). Trimeresurus hageni at the Reptarium.cz Reptile Database. Accessed 24 November 2012.. ...

*Protobothrops flavoviridis

Bothrops flavoviridis, pp. 492-493.) Protobothrops flavoviridis at the Reptarium.cz Reptile Database. Accessed 25 July 2007.. ...

*Adolfo Lutz

... and Bothrops lutzi, a venomous snake. Lutz-Jeanselme syndrome Beolens B, Watkins M, Grayson M. 2013. The Eponym Dictionary of ...

*GP1BA

Andrews RK, Booth WJ, Gorman JJ, Castaldi PA, Berndt MC (1989). "Purification of botrocetin from Bothrops jararaca venom. ...

*GP1BB

Andrews RK, Booth WJ, Gorman JJ, Castaldi PA, Berndt MC (1989). "Purification of botrocetin from Bothrops jararaca venom. ...

*Taipoxin

Gutiérrez, J. M.; Lomonte, B. (1995). "Phospholipase A2 myotoxins from Bothrops snake venoms". Toxicon. 33 (11): 1405-24. PMID ... a lysine-49 phospholipase A2 of Bothrops asper snake venom". Toxicon. 32 (11): 1359-69. PMID 7886694. ...

*Cerastocytin

For example, botrocetin, found in the venom of Bothrops jararaca, activates von Willebrand factor (vWF) by inducing it to bind ... In contrast, cerastocytin and cerastotin (from the venom of Cerastes cerastes), as well as thrombocytin (from Bothrops atrox) ... 74(3):1031-5 Niewiarowski S, Kirby EP, Brudzynski TM, Stocker K. (1979) Thrombocytin, a serine protease from Bothrops atrox ... 74(3):1031-5 Bothrops atrox venom. 2. Interaction with platelets and plasma-clotting factors. Biochemistry. 18(16):3570-7. ...

*Venombin A

Stocker, K.; Barlow, G.H. (1976). "The coagulant enzyme from Bothrops atrox venom (batroxobin)". Methods Enzymol. 45: 214-223. ...

*Glycoprotein IX

1990). "Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von ...

*List of venomous animals

Bothrops spp.), including the fer-de-lance (B. lanceolatus) and the terciopelo (B. asper) Bushmasters (Lachesis spp.) ...

*Teprotide

... is nonapeptide which has been isolated from the snake Bothrops jararaca. It is an angiotensin converting enzyme ... Ferreira, Sergio (February 1965). "A bradykinin-potentiating factor (bpf) present in the venom of bothrops jararaca". British ... "Angiotensin-converting enzyme inhibitors from the venom of bothrops jararaca. Isolation, elucidation of structure, and ... "Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom". Biochemistry. 9 (13): 2583-2593. doi:10.1021/ ...

*Philodryas olfersii

Philodryas does not cause the coagulopathy that Bothrops does. The bite of this snake is almost never lethal; only one fatality ... Patients complaining of snakebite may be given an antivenom for Bothrops snake venom, which is inappropriate for the treatment ...

*Porthidium hespere

Bothrops hesperis) Porthidium hespere at the Reptarium.cz Reptile Database. Accessed 15 September 2007.. ... A New Terrestrial Pit Viper of the Genus Bothrops (Reptilia, Serpentes, Crotalidae) from western Mexico. Journal of Herpetology ...

*Atropoides

Notes on Bothrops nummifera, mano de piedra or timbo. Bulletin of the Antivenin Institute of America. 2(3): 58. Müller JW von. ... Phylogenetic relationships of Central and South American pitvipers of the genus Bothrops (sensu lato): cladistic analyses of ...

*Yarara (disambiguation)

Yarara or Yarará is the common name of the venomous pit viper species Bothrops jararaca endemic to southern Brazil, Paraguay, ... Also known as Yarará perezosa (Argentina), jararaca (Brazil) Yarara may also refer to: Bothrops alternatus, a venomous pit ... Bothrops ammodytoides, a venomous pit viper species endemic to Argentina; common name Yarará ñata. EDESA Yarará, a self- ...

*Bothriechis supraciliaris

Bothrops schlegelii supraciliaris, new subspecies, pp. 791-794, Figure 39).. ...

*Bothropasin

... (EC 3.4.24.49, Bothrops jararaca venom metalloproteinase) is an enzyme. This enzyme catalyses the following ... Bothrops jararaca). Mandelbaum, F.J.; Reichel, A.P.; Assakura, M.T. (1982). "Isolation and characterization of a proteolytic ... enzyme from the venom of the snake Bothrops jararaca (jararaca)". Toxicon. 20: 955-972. doi:10.1016/0041-0101(82)90098-8. PMID ...

*Batroxobin

... , also known as reptilase, is a snake venom produced by Bothrops atrox and Bothrops moojeni, venomous species of pit ... There will be an overview of two different snakes, Bothrops atrox and Bothrops moojeni. When injected with batroxobin there ... Bothrops atrox was described by Carl Linnaeus as early as 1758, but batroxobin, the active compound in its venom, was first ... Batroxobin from Bothrops atrox mediates the formation of fibrin I. This then renders the blood more prone to coagulation. An ...

*Pirajá da Silva

A species of venomous snake, Bothrops pirajai, is named in his honor. Manoel Augusto Pirajá da Silva. bahiana.edu.br Manuel ...

*ACE inhibitor

Ferreira SH (February 1965). "A bradykinin-potentiating factor (bpf) present in the venom of bothrops jararaca". Br J Pharmacol ... Brazilian scientist Sérgio Henrique Ferreira reported a bradykinin-potentiating factor (BPF) present in the venom of Bothrops ...

*Bothrolysin

... (EC 3.4.24.50, Bothrops metalloendopeptidase J, J protease) is an enzyme. This enzyme catalyses the following ... Bothrops jararaca). Tanizaki, M.M.; Zingali, R.B.; Kawazaki, H.; Imajoh, S.; Yamazaki, S.; Suzuki, K. (1989). "Purification and ... some characteristics of a zinc metalloprotease from the venom of Bothrops jararaca (jararaca)". Toxicon. 27: 747-755. doi: ...
The ability of pre-existing antibodies to neutralize locally-acting toxins of Bothrops asper snake venom was investigated. Hemorrhage, myonecrosis, and edema were markedly reduced in actively immunized mice, although none of these effects was completely abolished. In mice passively immunized with equine antivenom, hemorrhage was prevented completely, while myonecrosis and edema were partially reduced. Pre-existing antibodies did not modify the early stage ( , 3 hr) of venom-induced edema, but significantly accelerated the normalization of this effect within 24 hr. Passive administration of antivenom either 5 or 120 min before venom injection gave similar results, suggesting that the presence of antibodies in the intravascular compartment may fully neutralize locally acting toxins, in this experimental animal model. Overall, the homologous or heterologous origin of antibodies was not a significant factor influencing their in uit,o neutralizing efficiency against local venom effects. Antibody ...
Phospholipases A(2) (PLA(2)s) are important components of Bothrops snake venoms, that can induce several effects on envenomations such as myotoxicity, inhibition or induction of platelet aggregation and edema. It is known that venomous and non-venomous snakes present PLA(2) inhibitory proteins (PLIs) in their blood plasma. An inhibitory protein that neutralizes the enzymatic and toxic activities of several PLA2s from Bothrops venoms was isolated from Bothrops alternatus snake plasma by affinity chromatography using the immobilized myotoxin BthTX-I on CNBr-activated Sepharose. Biochemical characterization of this inhibitory protein, denominated alpha BaltMIP, showed it to be a glycoprotein with Mr of similar to 24,000 for the monomeric subunit. CD spectra of the PLA(2)/inhibitor complexes are considerably different from those corresponding to the individual proteins and data deconvolution suggests that the complexes had a relative gain of helical structure elements in comparison to the individual ...
Order Recombinant Bothrops jararaca Thrombin-like enzyme TL-BJ 2 Thrombin-like enzyme TL-BJ 2 03015123706 at Gentaur Bothrops jararaca Thrombin-like TL-BJ 2[Thrombin-like TL-BJ 2]
Presented by M di-T. BOTHROPS LANCEOLATUS.. B. lanceolatus, Wagler-Dumeril; synonyms, Coluber glaucus, Linn. Vipera c rulescens, Laurent; Coluber megara, Shaw; Cophias lanceolatus, Merrem; Craspedocephalus lanceolatus, Gray (Trigonocephale jaune, Cuvier; Vipera jaune; Fer-de-lance).. An Ophidian of the family Crotalid , found in the Island of Martinique.. Authority. Dr. Ch. Ozanam, LArt. M d., 19, 116 (A collection of cases (15) and general observations on the effect of the bite, quoted from Dr. Rufz, Enqu te sur le serpent de la Martinique.). MIND. ► Consecutive and long-lasting hypochondria. ► Ideas confused. ► Coma, becoming deeper until death ensues.. HEAD. ► Vertigo. ► Frequent dizziness. ► Hemicrania.. EYE. ► Amaurosis (sometimes immediately after the bite). ► Persistent amaurosis. ► Amaurosis, without perceptible dilatation of the pupil. ► Hemeralopic amaurosis; can scarcely see her way, especially after sunrise. [10.] ► Pupil a little dilated.. FACE. ► Altered ...
Angiogenesis and wound repair are mediated by several growth factors that are strictly released. Alternagin-C (ALT-C), a disintegrin-like protein from the venom of Bothrops alternatus induces in vivo angiogenesis as well as the cyclic peptide derived from its primary structure, with the ECD motif (ALT-C PEP). This study investigated the effects of ALT-C and ALT-C PEP on angiogenesis and expression of growth factors in a model of wounded rat skin. The rats were anaesthetized; one cutaneous excision (4 mm diameter) was made on the back of each animal, close to the cervical area. Animals were then divided into 7 groups (five rats/group): control (treated with vehicle); locally treated with 10, 60 and 100 ng ALT-C or 10, 20 and 100 ng ALT-C PEP ALT-C PEP for 1, 3, 5 or 7 consecutive days. At the end of experiments animals were killed, the skin was removed; the cranial portion was used for histological analysis and from the caudal portion; protein were extracted, separated by SDS-PAGE and VEGF, ...
Sigma-Aldrich offers abstracts and full-text articles by [Marcelo L Santoro, Tais S Vaquero, Adriana F Paes Leme, Solange M T Serrano].
Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.
Common names: fer-de-lance, terciopelo, Bothrops asper is a highly venomous pit viper species ranging from southern Mexico to northern South America. Sometimes referred to as the "ultimate pit viper", these snakes are found in a wide range of lowland habitats, often near human habitations. Its proximity to human habitations and temperament are likely the reasons why it is considered more dangerous to humans than others. This species is the main cause of snakebite incidents within its range. No subspecies are currently recognized. The generic name, Bothrops, comes from the Greek words bothros and ops, which mean "pit" and "face" (or "eye"), respectively. This is a reference to these snakes highly sensitive heat-detecting pit organs. The specific epithet, asper, which is a Latin word meaning "rough" or "harsh", may allude to the species keeled dorsal scales. Some of the common names applied to this snake are terciopelo, fer-de-lance, Mapepire balsain (Trinidad), barba amarilla (Guatemala, ...
Sigma-Aldrich offers abstracts and full-text articles by [Isabel C O Morais, Gustavo J S Pereira, M Orzáez, Roberta J B Jorge, Claudia Bincoletto, Marcos H Toyama, Helena S A Monteiro, Soraya S Smaili, Enrique Pérez-Payá, Alice M C Martins].
Bothrops jararacussu snake venom produces myonecrosis and nerve degeneration. In this work, we investigated whether nerve lesions or impaired muscle regeneration contributed to the permanent loss of muscle mass, a long-term sequela of envenoming. The right soleus muscle of adult male mice was injected with B. jararacussu venom (80 mug) while the left muscle received only saline (control). The mice were killed after 2 and 3 months and the muscles were removed and processed for examination by transmission electron microscopy and light microscopy. The nerve fibers, Schwann cells and neuromuscular junctions had regenerated in venom-treated muscle. The total number of muscle fibers was significantly lower (p , 0.05) than in the control (617 +/- 48 versus 1235 +/- 97, respectively; mean +/- SEM, n = 10). These results show that the loss of muscle mass was most likely related to a decrease in the ability of the muscle to regenerate rather than to nerve lesions. (C) 2004 Elsevier Ltd. All rights reserved ...
An enzyme-immunoassay (EIA) for the quantitation of antibodies against myotoxins present in the venoms of Bothrops asper (Costa Rica), B. atrox (Colombia) and B. moojeni (Brazil), was developed. This EIA was utilized for the evaluation of four antivenoms produced in Mexico (Laboratorios Myn; MYN), Costa Rica (Instituto Clodomiro Picado; ICP), Colombia (Instituto Nacional de Salud; INS) and Brazil (Instituto Butantan; IB). Antivenoms ICP, IB and INS showed a higher titer of antibodies against the three myotoxins tested, with only slight differences between them, depending on the antigen utilized. In contrast, MYN antivenom had very low levels of antibodies to the three myotoxins. Seventeen batches of ICP antivenom were analyzed by EIA, using B. asper myotoxin II as antigen. Although all batches had high anti-myotoxin titers, these varied significantly. Batches produced after 1988 had, in general, higher titers than older (1986-1987) ones. Antivenom stored for one year at 37 degrees C had a ...
J. C. Cogo, J. Prado-Franceschi, M. A. Cruz-Hofling, A. P. Corrado and L. Rodrigues-Simioni. Effect of Bothrops insularis venom on the mouse and chick nerve-muscle preparation. Toxicon 31, 1237-1247, 1993.-The effects of Bothrops insularis venom were examined in vivo in mice and chicks and in vitro using the mouse phrenic nerve diaphragm and chick biventer cervicis muscle preparations. Incubation of the indirectly or directly stimulated mouse preparation with B. insularis venom (20-80 μg/ml) produced an initial increase in twitch tension followed by irreversible blockade. With direct stimulation in the presence of d-tubocurarine, no increase in twitch tension was observed prior to the onset of blockade. A venom-induced effect on presynaptic activity was suggested by the marked increase in the frequency of the mepps recorded in vitro 5-15 min after venom addition. A direct muscular effect was shown by the dose- and time-dependent reduction in the resting membrane potential of the diaphragm. ...
Myotoxic phospholipases A2 (PLA2) are responsible for many clinical manifestations in envenomation by Bothrops snakes. A new myotoxic acidic Asp49 PLA2 (BaCol PLA2) was isolated from Colombian Bothrops asper venom using reverse-phase high performance liquid chromatography (RP-HPLC). BaCol PLA2 had a molecular mass of 14,180.69 Da (by mass spectrometry) and an isoelectric point of 4.4. The complete amino acid sequence was obtained by cDNA cloning (GenBank accession No. MF319968) and revealed a mature product of 124 amino acids with Asp at position 49. BaCol PLA2 showed structural homology with other acidic PLA2 isolated from Bothrops venoms, including a non-myotoxic PLA2 from Costa Rican B. asper. In vitro studies showed cell membrane damage without exposure of phosphatidylserine, an early apoptosis hallmark. BaCol PLA2 had high indirect hemolytic activity and moderate anticoagulant action. In mice, BaCol PLA2 caused marked edema and myotoxicity, the latter seen as an increase in plasma creatine kinase
Thrombin-like enzyme that shows clotting activity upon human plasma. Shows specific fibrinogenolytic activity for Aalpha chain (FGA). Hydrolyzes fibrin, BAPNA and TAME, as well as chromogenic artificial substrates of the blood coagulation cascasde: S-27654 for factor X (F10), S-2302 for kallikrein (KLK), factor XIa (F11), and XIIa (F12), and S-2266 for kallikrein and factor XIa (F11). Subcutaneous injection into mice induces a mild edema. Intravenous and intramuscular injection reduce plasma fibrinogen concentration and increase the levels of fibrin(ogen) degradation products. Intramuscular injection also promotes an increase in the expression of proMMP-9, but is unable to activate it.
International Scholarly Research Notices is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journals Editorial Board as well as its Table of Contents are divided into 108 subject areas that are covered within the journals scope.
Loss of venom from the venom gland after biting or manual extraction leads to morphological changes in venom secreting cells and the start of a cycle of production of new venom. We have previously shown that stimulation of both (alpha- and beta-adrenoceptors in the secretory cells of the venom gland is essential for the onset of the venom production cycle in Bothrops jararaca. We investigated the signaling pathway by which the alpha(1)-adrenoceptor initiates the venom production cycle. Our results show that the alpha(1)-adrenoceptor subtype is present in venom gland of the snake. in quiescent cells, stimulation of alpha(1)-adrenoceptor with phenylephrine increased the total inositol phosphate concentration, and this effect was blocked by the phospholipase C inhibitor U73122. Phenylephrine mobilized Ca(2+) from thapsigargin-sensitive stores and increased protein kinase C activity. in addition, alpha(1)-adrenoceptor stimulation increased the activity of ERK 1/2, partially via protein kinase C. ...
We report the detailed molecular characterization of two PLA2s, Lys49 and Asp49 isolated from Bothrops leucurus venom, and examined their effects against Dengue virus (DENV). The Bl-PLA2s, named BlK-PLA2 and BlD-PLA2, are composed of 121 and 122 amino acids determined by automated sequencing of the native proteins and peptides produced by digestion with trypsin. They contain fourteen cysteines with pIs of 9.05 and 8.18 for BlK- and BlD-PLA2s, and show a high degree of sequence similarity to homologous snake venom PLA2s, but may display different biological effects. Molecular masses of 13,689.220 (Lys49) and 13,978.386 (Asp49) were determined by mass spectrometry. DENV causes a prevalent arboviral disease in humans, and no clinically approved antiviral therapy is currently available to treat DENV infections. The maximum non-toxic concentration of the proteins to LLC-MK2 cells determined by MTT assay was 40 µg/mL for Bl-PLA2s (pool) and 20 µg/mL for each isoform. Antiviral effects of Bl-PLA2s were
Bothrops marajoensis is found in the savannah of Marajo Island in the State of Par S and regions of Amapa State, Brazil. The aim of the work was to study the renal and cardiovascular effects of the B. marajoensis venom and phospholipase A(2) (PLA(2)). The venom was fractionated by Protein Pack 5PW. N-terminal amino acid sequencing of sPLA(2) showed amino acid identity with other lysine K49sPLA(2)s of snake venom. B. marajoensis venom (30 mu g/mL) decreased the perfusion pressure, renal vascular resistance, urinary flow, glomerular filtration rate and sodium tubular transport. PLA(2) did not change the renal parameters. The perfusion pressure of the mesenteric bed did not change after infusion of venom. In isolated heart, the venom decreased the force of contraction and increased PP but did not change coronary flow. In the arterial pressure, the venom and PLA(2) decreased mean arterial pressure and cardiac frequency. The presence of atrial flutter and late hyperpolarisation reversed, indicating ...
The story of angiotensin converting enzyme (ACE) inhibitors started approximately 50 years ago, when it was discovered that human plasma incubated with the venom of the Brazilian viper,Bothrops Jararaca, generated a hypotensive compound. This discovery quickly led to the characterisation of the active principle of the venom by Fereira and Greene as a family of peptides, which were named bradykinin potentiating factors as they selectively improved the biological effects of bradykinin. The observation was then made by Vane that these peptides could also block the conversion of angiotensin I into angiotensin II via the angiotensin converting enzyme. The active peptides were isolated and teprotide became the first ACE inhibitor to be evaluated clinically. The search for an orally active compound that was sufficiently potent to be developed as an antihypertensive drug resulted in the design and development of captopril, which entered first phase clinical studies in 1977.. ACE has a key role in two ...
This drug is slightly more popular than comparable drugs? If it will help reduce wrinkles and brown spots it will make getting older easier? Present in the venom of Bothrops jararaca, list of usa online casinos a South American pit viper, in 1965? Astonishingly, Asprey says even if it were to turn out that Provigil could shorten his life he wouldnt give it up and neither would the lobbyist or brain researcher who take it? Asbestos: cialis uk over the counter meltingly Risk Assessment, Epidemiology, and Health Effects? Consistent with Title VII, list of usa online casinos Indian tribes and tribally-owned businesses may prefer indigenous people in hiring. An independent judiciary and an independent and active bar are dedicated to the ideal and reality of fair trials and appellate procedures. Climestra libido pills enhance sexual vitality, list of usa online casinos intensity, interest and excitement! Viagra® demonstrou melhora estatisticamente significativa comparada com placebo em todos os 21 ...
Sérgio Henrique Ferreira (October 4, 1934 - July 17, 2016) was a Brazilian physician and pharmacologist noted for the discovery of the bradykinin potentiating factor, which led to new and widely used anti-hypertension drugs - the ACE inhibitors. Ferreira received his M.D. from the Faculty of Medicine of Ribeirão Preto of the University of São Paulo (USP) and soon became staff member of the same school, where he is a member of the Department of Pharmacology. His research training in pharmacology initiated in this Department with Prof. Maurício Rocha e Silva, the discoverer of bradykinin. While working on this subject, he discovered a family of peptides present in the venom of a Brazilian snake, Bothrops jararaca, which inhibited kininase activity and strongly potentiated the effects of bradykinin in vivo and in vitro. This factor was named bradykinin potentiating factor, BPF. In 1968, with the collaboration of Dr. Lewis Joel Greene, from the Brookhaven National Laboratory, U.S., he isolated ...
A toxic phospholipase A was isolated from the venom of Bothrops asper. It induced skeletal muscle damage, anticoagulant effects and edema in the foot pad. The toxin had an intravenous LD50 of 95 micrograms/16-18 g mouse ...
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The great legendary Bill Haast, pioneer of venom production for venom research since 1946, was founder and director of the world renowned Miami Serpentarium Laboratories
Introduction. Bothrops pirajai snake is an endemic species from the South region of Bahia state, Brazil, and it belongs nowadays to a national list of Brazilian fauna species threatened of extinction (Martins & Molina, 2008). Its venom is rich in proteins such as phospholipases A2, desintegrins, metalloproteases, serinoproteases, L-amino acid oxidases and others (Rodrigues et al., 2009). L-amino acid oxidases (LAAO, EC 1.4.3.2) are enantioselective flavoenzymes catalyzing the oxidative deamination of a wide range of L-amino acids (Stábeli et al., 2007). During the reductive half-reaction, the amino acid substrate is oxidized to the imino acid with concomitant reduction of the flavin adenine dinucleotide (FAD) cofactor. The imino acid product of oxidation undergoes a non-enzymatic hydrolysis to give the respective α-keto acid and ammonia. An oxidative half-reaction completes the catalytic cycle re-oxidizing the FAD with molecular oxygen and producing hydrogen peroxide (Moustafa et al., ...
Nine of the 17 venoms here tested were found capable of coagulating citrated blood or plasma. As has been believed by most workers in the field, 7 of these 9 coagulant venoms convert fibrinogen to an insoluble modification resembling fibrin (Bothrops atrox, Bothrops jararaca, Bothrops nummifera, Crotalus adamanteus, Crotalus horridus, Crotalus terrificus basiliscus, Crotalus terrificus terrificus). The optimum pH for this coagulation was determined for 3 of these, and was found in each case to be approximately pH 6.5, the same as that for the action of thrombin on fibrinogen. Unlike thrombin, however, the fibrinogen-coagulating activity of the venoms was unaffected by the antithrombin elaborated in the course of anaphylactic shock.. In addition to coagulating fibrinogen directly, 3 of these venoms (Bothrops atrox, Bothrops jararaca, and to a less extent, Crotalus terrificus basiliscus) acted on prothrombin to convert it to thrombin, without the necessary intervention of either calcium or ...
Bothropstoxin-I (BthTx-I) is a Lys49-phospholipase A2 from the venom of Bothrops jararacussu which demonstrates both myotoxic and Ca2+-independent membrane-damaging activities. The structural determinants of these activities are poorly defined, therefore site-directed mutagenesis has been used to substitute all cationic and aromatic residues between positions 115 and 129 in the C-terminal loop region of the protein. Substitution of lysine and arginine residues with alanine in the region 117-122 resulted in a significant reduction of myotoxic activity of the recombinant BthTx-I. With the exception of Lys122, these same substitutions did not significantly alter the Ca2+-independent membrane-damaging activity. In contrast, substitution of the positively-charged residues at positions 115, 116 and 122 resulted in reduced Ca2+-independent membrane-damaging activity but, with the exception of Lys122, had no effect on myotoxicity. These results indicate that the two activities are independent and are ...
Bothrops punctatus is an endangered, semi-arboreal pitviper species distributed in Panamá, Colombia, and Ecuador, whose venom is poorly characterized. In the present work, the protein composition of this venom was profiled using the snake venomics analytical strategy. Decomplexation of the crude venom by RP-HPLC and SDS-PAGE, followed by tandem mass spectrometry of tryptic digests, showed that it consists of proteins assigned to at least nine snake toxin families. Metalloproteinases are predominant in this secretion (41.5% of the total proteins), followed by C-type lectin/lectin-like proteins (16.7%), bradykinin-potentiating peptides (10.7%), phospholipases A2 (93%), serine proteinases (5.4%), disintegrins (38%), L-amino acid oxidases (3.1%), vascular endothelial growth factors (17%), and cysteine-rich secretory proteins (1.2%). Altogether, 6.6% of the proteins were not identified. In vitro, the venom exhibited proteolytic, phospholipase A2, and L-amino acid oxidase activities, as well as angiotensin
Fer-de-lance Bothrops atrox or Bothrops lanceolatus The Fer-de-lance (also known as Lancehead) are several closely related species in this group. All are very considered to be very aggressive and dangerous to man and one of the most feared snakes on the planet. Description: Lancehead or Fer-de-lance snakes have highly variable ...
Publication date: Available online 12 December 2019Source: BiologicalsAuthor(s): Hebleen Brenes, Gilbert D. Loría, Bruno LomonteAbstractSecreted phospholipase A2 (sPLA2) molecules are small, calcium-dependent enzymes involved in many biological processes. Viperid venoms possess gIIA sPLA2s and sPLA2-like proteins, both having homology to human gIIA sPLA2, an innate immunity enzyme. We evalu...
Atlantic Forest Virginia Morrell Mark Moffett biology conservation Rain Forest in Rio s Backyard Adriano Chiarello snakes sloths muriquis tamarins porcupine plants green amphibian species environmentalists destruction habitat rare unique animals human sprawl HotSpot Catholic University of Minas Gerais S o Louren o Municipal Park Mata Atl ntica Bothrops jararaca Ann Williams
[Purification and isolation of isoenzymes of L-amino acid oxidase from the venom of Bothrops asper].: L-amino acid oxidase (E.C. 1.4.3.2) was purified from the
Garden Buddies Ok….not quite buddies, but we could call them co-workers. The Fer-de-Lance or "Terciopelo", is one of the most dangerous snakes south of Texas. The name means "velvet" in Spanish and is the common name used in Costa Rica. Its scientific name is the "Bothrops asper". This snake is…. Continue reading. ...
Garden Buddies Ok….not quite buddies, but we could call them co-workers. The Fer-de-Lance or "Terciopelo", is one of the most dangerous snakes south of Texas. The name means "velvet" in Spanish and is the common name used in Costa Rica. Its scientific name is the "Bothrops asper". This snake is…. Continue reading. ...
My laboratory, in collaboration with my colleague Dr. Jon Bjarnason, was one of the first to identify and characterize the metalloproteinases present in numerous snake venoms. These Snake Venom Metalloproteinases; SVMPs are responsible for many of the pathologies associated with snake envenoming. Our research has elucidated the structures of these toxins and identified the biochemical and cellular mechanisms by which the toxins function to give rise to their noted pathologies. Specifically my research interests have been centered on metalloproteinases and extracellular matrix and the processes they regulate in normal and pathological circumstances. Our recent focus has expanded to include the interaction of host and tumor in carcinogenesis and metastasis and the role of stromal microenvironment, inflammation in cancer metastasis and invasion. We are also carrying out research on the discovery and validation of biomarkers associated with normal and chronic wound healing. Our longstanding interest ...
Lys49 phospholipase A2 homologues constitute a group of catalytically-inactive proteins, present in the venoms of many crotalid snakes, which induce myonecrosis. Current evidence supports the mapping of their toxic site to the C-terminal region, where amino acids comprised within the sequence 115-129 appear to play a central role in toxicity. This study evaluated the possible toxic effects of several synthetic peptides corresponding to the sequence 115-129 of different Lys49 myotoxins, using in vitro cytotoxicity and in vivo myotoxicity assays. Peptides varied widely in their activities, ranging from fully toxic to harmless. Thus, the toxic actions of Lys49 myotoxins cannot always be reproduced by their free peptides 115-129. Peptides from Agkistrodon p. piscivorus (AppK) and A. contortrix laticinctus Lys49 myotoxins exerted both cytotoxicity and myotoxicity. Random scrambling of peptide AppK resulted in complete loss of toxicity, demonstrating that its specific sequence of residues, rather than ...
Stock Photo of Queensland Groper Epinephelus lanceolatus. High Quality Queensland Groper Images and Gloss Prints are available from Oceanwide Images Stock Photo Library.
Stock Photo of Queensland Groper Epinephelus lanceolatus. High Quality Queensland Groper Images and Gloss Prints are available from Oceanwide Images Stock Photo Library.
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additional source King, C.M.; Roberts, C.D.; Bell, B.D.; Fordyce, R.E.; Nicoll, R.S.; Worthy, T.H.; Paulin, C.D.; Hitchmough, R.A.; Keyes, I.W.; Baker, A.N.; Stewart, A.L.; Hiller, N.; McDowall, R.M.; Holdaway, R.N.; McPhee, R.P.; Schwarzhans, W.W.; Tennyson, A.J.D.; Rust, S.; Macadie, I. (2009). Phylum Chordata: lancelets, fishes, amphibians, reptiles, birds, mammals, in: Gordon, D.P. (Ed.) (2009). New Zealand inventory of biodiversity: 1. Kingdom Animalia: Radiata, Lophotrochozoa, Deuterostomia. pp. 431-554. [details] ...
A 50 kDa protein that inhibits platelet adhesion to collagen has been isolated from snake venom of Crotalus atrox (western diamondback rattlesnake) and has been named catrocollastatin. The cDNA cloning of catrocollastatin has been accomplished. A full-length cDNA of 2310 bp with an open reading frame between nucleotides 51 and 1880 was obtained. The deduced amino acid sequence consists of 609 amino acids. The cDNA-predicted amino acid sequence is highly similar to that of haemorrhagic metalloproteinase jararhagin from Bothrops jararaca venom, HR1B from Trimeresurus flavoviridis, Ht-e from C. atrox and trigramin from T. gramineus. Like jararhagin and HR1B, catrocollastatin is a multidomain molecule composed of an N-terminal domain, a metalloproteinase domain, a disintegrin-like domain and a cysteine-rich C-terminal domain. In the disintegrin-like domain, the frequently seen RGD (Arg-Gly-Asp) sequence is replaced by SECD (Ser-Glu-Cys-Asp). This cDNA was expressed in Spodoptera frugiperda (fall ...
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Böhlke, E.B. and J.E. Randall, 2000. A review of the moray eels (Anguilliformes: Muraenidae) of the Hawaiian Islands, with descriptions of two new species. Proc. Acad. Nat. Sci. Philad. 150:203-278. (Ref. 35990 ...
The formation of a blood clot depends on a number of proteins found within plasma called clotting factors. Normally the clotting factors are inactive and do not cause clotting. Following injury however, the clotting factors are activated to produce a clot. This is a complex process involving chemical reactions, but it can be summarized in 3 main stages; the chemical reactions can be stated in two ways: just as with platelets, the contact of inactive clotting factors with exposed connective tissue can result in their activation. Chemicals released from injured tissues can also cause activation of clotting factors. After the initial clotting factors are activated, they in turn activate other clotting factors. A series of reactions results in which each clotting factor activates the next clotting factor in the series until the clotting factor prothrombin activator is formed. Prothrombin activator acts on an inactive clotting factor called prothrombin. Prothrombin is converted to its active form ...
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ANSWER: Prothrombin activator formed by intrinsic and extrinsic systems, converts prothrombin to thrombin which converts fibrinogen to fibrin which forms a clot with platelets ...
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Snake prothrombin activator that attacks the hemostatic system of prey. This catalytic subunit is functionally similar to blood coagulation factor Xa. It requires a non-catalytic subunit present in the venom, which is similar to coagulation factor Va, to be fully active (By similarity).
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. ...
5-nucleotidase is an enzyme with system name 5-ribonucleotide phosphohydrolase. This enzyme catalyses the following chemical reaction:a 5-ribonucleotide + H2O↔ a rib
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Doctors Without Borders says the world will run out of one of the most effective treatments for snakebites next year, risking the lives of tens of thousands of people, mostly in developing countries.... World News Summaries. | Newser
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Can you name the players who played for Finland in IHWC 1996-2010? Test your knowledge on this sports quiz to see how you do and compare your score to others. Quiz by Bleu
Beizhan Yan, Uta Passow, Jeffrey P. Chanton, Eva-Maria Nöthig, Vernon Asper, Julia Sweet, Masha Pitiranggon, Arne Diercks, and Dorothy Pak ...
A few years ago, if someone said that youd be risking your neck for that of another, you would have laughed right in their face. There was no way you of all people would put your life on the line for people you hardly knew, or complete strangers for that matter. You grew up alone, raised yourself alone, survived alone, and climbed your way up to the top of the corporate ladder alone. Granted, a couple mutated genes saddled you with some unwanted superpowers along the way, but youve managed with it so far; its not as if having the ability to regenerate is too much of a burden ...
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The gross effect of protein factors from mouse salivary glands and certain snake venoms on the growth, in tissue culture, of expiants of sensory ganglia from chick embryos is well established (Levi-Montalcini, 1964, 1965; Angeletti, Calissano, Chen & Levi-Montalcini, 1967; Banks et al. 1968; Varon, Nomura & Shooter, 1967a, b). The effects of these substances, called nerve growth factors, on individual neurons in vitro have, however, been little investigated and no quantitative studies have been reported. In order to make such a study we required a method of making cell suspensions of high density from chick embryonic sensory ganglia: the target tissue normally used for the assay of nerve growth factors.. Several methods for obtaining dispersed cells from nervous tissue are recorded in the literature and, of these methods, micro-dissection of mammalian central nervous tissue (Hyden, 1959; Lowry, 1962; Hyden & Lange, 1965) appears to result in the least damage to cells.. ...
Objectives : To identify the toxicity profile of snakebites and to assess clinical severity. Methods : An analysis of all patients admitted to Ngwelezane Hospital's Emergency Department with a diagnosis of snakebite over five years was done. All patients were admitted, assessed and standard haematological and biochemical tests were done. Patients were observed for a minimum of 12 hours' observation. Results : In total, 879 cases were analysed. Envenomation was identified in over two-thirds of admissions. Cytotoxic snakebites accounted for 98% of envenomations. Only four cases of haemotoxic bleeding and five cases of neurotoxicity were admitted. Abnormal laboratory indices correlated with severity: INR > 1 5 (odds ratio 2.25, CI 1.12-4.53; p = 0.023), platelets < 100x109/L (OR 2.35, CI 1.01- 5.49; p = 0.048), haemoglobin concentration < 8.0 g/dL (OR 5.68, CI 2.15-15.00; p < 0.001) and leucocyte count > 10x109 (OR 3.15, CI 1.89-5.26, p < 0.001). Children and delays to admission
Curious to know about venom and its usage! Snake Venom means snakes poison. Stay away from it. Venom is poisonous fluid generate by animals such as snakes,
A nanofiber hydrogel infused with snake venom may work better than anti-coagulants to stop bleeding quickly, a new study suggests.
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Snake venom is sometimes used as medicine; recent research has shown that snake venom may have value in treating cardiovascular diseases.
Le Lotus Bleu has announced DuneSteps, a soundset featuring pure electronic presets for the DUNE synthesizer instrument by Synapse Audio.
Most people these days consume beer solely for the health benefits, but for those who want to be intoxicated by more than just the lure o...
The woman in the picture is Ashley Braistle and she was born with more than 4 limbs: a condition known as POLYMELIA. Another person in ...
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Genetic information processingProtein fateDegradation of proteins, peptides, and glycopeptidesperiplasmic serine peptidase DegS (TIGR02038; EC 3.4.21.-; HMM-score: 18.5) ...
Genetic information processingProtein fateDegradation of proteins, peptides, and glycopeptidesperiplasmic serine peptidase DegS (TIGR02038; EC 3.4.21.-; HMM-score: 139.4) ...
Slidin into the DMs! BJ Novak is in a relationship with a 21-year-old Instagram model he met online, and, according to Page Six, its a bit of an odd pairing.
Back on the good side, theres separate sinks for food prep and nappy changes. Yippee!!! This is a great feature of all the Parent Rooms reviewed at Westpoint. The nappy change sink is in the middle of the change bays, with a soap dispenser in arms reach. The food prep sink is on a separate bench with the microwave and bottle warmer. Having both a bottle warmer and microwave is pretty rare, giving this room another tick.. On the down side, for drying hands theres only an automatic hand-dryer. Paper towel is much more hygienic and convenient. Id like to see the hand-dryer removed and have paper towel units installed in its place. My little one hates the sound of hand dryers, and Im guessing other kids have the same reaction too. So why not get rid of them? ...
Hemorrhage is the most potent manifestation of envenomation by Vipera ammodytes ammodytes (V. a. ammodytes) venom in man. A detailed description of the venom components contributing to this effect is thus medically very important. We have characterized a novel component, termed here VaH3, as a potently hemorrhagic snake venom metalloproteinase (SVMP). Its proteolytic activity and overall stability depend on the presence of Zn(2+) and Ca(2+) ions. The molecular mass of this slightly acidic molecule, determined by MALDI/TOF analysis, is 104 kDa. Chemical reduction and S-carbamoylmethylation result in a single monomer of 53.7 kDa. N-deglycosylation decreased this mass by 4.6 kDa. The complete amino acid sequence of VaH3 was determined by protein and cDNA sequencing, showing that each of the identical glycoprotein subunits comprise a metalloproteinase, a disintegrin-like domain and a cysteine-rich domain, VaH3 belongs to the P-IIIc class of SVMPs. It shows strong sequence similarity to vascular endothelial
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There is no way to find out by just reading this, but Ive heard a lot about snake venom deforming tissues after exposure, now Im not saying that you should just take some venom and the penis will get bigger. But what Im suggesting that further studies of snake venom and the reactions of tissue under controlled environments might lead the way to understand the benefits of tissue deformation without death. There is an antidote for the snake venom if bitten in the wild, it uses a plant of some kind which acts alone in some cases and target the venom in the nervous system rendering the venom useless as it deforms the cells.. Could a controlled dose of venom mixed with another tissue isolating chemical change the size of cells in the penis? Could such a thing be possible? Its a long shot so dont all laugh at once, but its the ideas that people have that spark discovery.. Here is some facts on what people are trying.. The relationship between microstructural features and macroscopic mechanical ...
Learn something to Save Your Life & that of others… Know About Snakebite How to Avoid Getting Bitten First Aid & Treatment How NOT to Treat Snakebite About Venom - About Antivenom Serum KNOW ABOUT SNAKEBITE Total ignorance prevails about snakes and snakebite in India and because of the deep-rooted superstitions many precious lives are lost…
The Atlas of Florida Plants provides a source of information for the distribution of plants within the state and taxonomic information. The website also provides access to a database and images of herbarium specimens found at the University of South Florida and other herbaria.
Marian Blanca Ramírez from the CSIC in Spain has been studying the effects of LRRK2, a protein associated with Parkinsons disease, on cell motility. A Travelling Fellowship from Journal of Cell Science allowed her to spend time in Prof Maddy Parsons lab at Kings College London, learning new cell migration assays and analysing fibroblasts cultured from individuals with Parkinsons. Read more on her story here. Where could your research take you? The deadline to apply for the current round of Travelling Fellowships is 30 Nov 2017. Apply now!. ...
It is estimated that every year, over 100,000 human deaths can be attributed to snakebite from the worlds 700 venomous snake species -- all inflicted in self-defence when the snakes feel threatened by encroaching humans. However, a new piece of research concludes that snake venom did not evolve as a defence mechanism.
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Bewleys Theatre), Durang Durang (Brazen Tales). David Fennelly makes his Devious Theatre debut in The Hellfire Squad. David graduated from the Gaiety School of Acting Full Time Acting Course in June 2009. He made his screen debut with a supporting role in Nick Hamms Killing Bono. He has since featured in Game of Thrones (HBO), Half Shade (UNA Films) What Richard Did (Element Pictures) and Sanctuary (Venom Productions). David wrote and performed in the stage play Fishes. Fishes was recently made into a short film The Caller in which David also acted. Recent theatre credits include This Lime Tree Bower (Project Arts Centre) Advocacy (Best Ensemble Fringe 14), Fishes (Stuart Parker Bursary 14), Mavericks (Theatre Upstairs/ Bewleys Theatre) and two once off performances in Abbey Theatre with 24 Hour Plays and Seven Jewish Children. Dave Fleming also makes his Devious Theatre debut in The Hellfire Squad. Dave began his acting career in UCD Dramsoc. Credits include Jacob in Spectres (Sickle Moon ...
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Corbin Bleu Height Weight Body Statistics. Corbin Bleu Height -1.80 m, Weight -76 kg, Measurements -43 chest, 15 biceps, waist, shoe size, workout, diet
As of February 2018, the World Health Organization (WHO) has estimated that approximately 5.5 million people are bitten by snakes each year, and about 2.7 million contracts a deadly disease called snakebite envenoming. This is an issue in most tropical and subtropical regions of the world.
Australias Royal Flying Doctor Service has updated its advice and procedures following the publication of a new 10 year study into snakebites.
The dreaded Matabuey, a snake so fearsome its name means ox killer, has a deadly bite that immobilizes its prey in minutes, making it the kind of creature generally to be avoided. But far from steering clear of the legless ...
There is a good reason why the snake is a symbol for the medical profession in America. - Dr. Naftali Primor.As the world looks to nature to find cures f
On 15 October 2011, in the presence of Hervé This, the physical-chemist and the co-creator of molecular gastronomy, Le Cordon Bleu chefs prepared a
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Pollen & Bleu @ Farrer Drive courtesy of Singland Development Pte Ltd carries a contemporary residence proudly established along Farrer Drive District 10. this kind of property offers a total land area of about 67, 471 sq. feet along with the site area of 6, 268 square meter plus 10, 030 square meters allowable gross floor area and stalls at eight storey building. This project holds 99-yearsleasehold tenure where modern look and state-of-the-arts facilities attempt to grasp you and your family ...
IN-FORM Present Bleu, representing the champion combination of trainer Martin Pipe and jockey Tony McCoy, can put punters in the black by continuing his winning sequence in the Dean & Dyball Handicap Hurdle at Exeter this afternoon.
A Natural Approach To Health Living With a Snakebite I had a question the other day about snakebites. There are 4 types of poisonous snakes in
Clinical Toxinology Resources Website provides information on venoms, toxins, antivenoms, diagnosis, treatment and emergency medicine, for snakebite, spiderbite, envenoming and poisoning by animals, plants, mushrooms.
Until the past few years, the recommended first aid for a snakebite was to tourniquet the area above the bite, cut the skin open, suck out the venom and then spit it out. The reasoning behind this was that you could remove much of the venom before it had a chance to enter the victims bloodstream. However, a study published in the New England Journal of Medicine in 2002 officially refuted this method [source: OConnor]. Venom enters the bloodstream extremely quickly, and trying to suck it out is ineffective. The best way for a bite victim to prevent venom from quickly moving through the bloodstream is to remain calm, keep the wound below the heart, and avoid running or doing anything that would increase the heart rate.. Many first aid and snakebite kits contain a suction device for removing venom from a snakebite wound. These devices provide way more suction than your mouth ever could and dont require an incision (which is dangerous and could cause infection). Tip: If your snakebite kit ...
A University of Arizona researcher developing a therapy to prevent or delay the dangerous results of rattlesnake and other venomous snakebites in humans has shown that a combination of carbon monoxide and iron inhibits snake venoms effects for up to an hour in animals, a major advance in bringing the treatment to market.. Snake venom is hemotoxic-destructive to the ability of blood to clot-and can cause the destruction of fibrinogen, an essential protein that enables blood to clot and stop excessive bleeding. Snake-venom enzymes also can cause abnormally fast clotting, which can lead to heart attack, stroke and damage to the bodys organs. Both reactions are inhibited by the therapy.. Vance G. Nielsen, professor and vice chair for research in the Department of Anesthesiology at the UA College of Medicine - Tucson, has confirmed that, if given soon enough after a snake bite, the carbon monoxide-iron-based therapy directly can inhibit snake venoms ability to block blood clotting in laboratory ...
As serpentes peçonhentas dos gêneros Bothrops e Crotalus têm sido mantidas em cativeiro visando à extração de venenos para a produção de imunobiológicos. O conhecimento da fisiologia desses animais e as alterações na concentração de proteínas e suas frações séricas são importantes para a identificação precoce de importantes enfermidades que cursam com estados de hipoproteinemia e hiperproteinemia. O objetivo do trabalho foi determinar a concentração de proteína total e o perfil eletroforético das proteínas séricas de serpentes Crotalus durissus terrificus (cascavel) criadas em cativeiro. Foram colhidas amostras de sangue da veia coccígea ventral de 21 serpentes adultas e sadias, divididas em dois grupos: Grupo 1 de 12 machos com peso médio de 588,89±193,55g, e Grupo 2 de nove fêmeas com peso médio de 708,33±194,04g. A proteína total sérica foi determinada pelo método de refratometria e a eletroforese em gel de agarose. Obtiveram-se valores da proteína total ...
Boris, a sweet 11 month old male British Shorthaired cat presented to the clinic after his owners had noticed he had been lethargic for a few days. Boris would walk for a short distance and then lie down. Upon presentation with Dr Thulz, it was noted that Boris was walking slightly stilted in the consultation and was constantly licking his lips.. As Boris lives in a snake area and is an outdoors cat, the possibility of Boris having snake bite toxicity was high as he presented with these symptoms.. To learn more about snake bites and your pet, click here: http://brunswickcentralvet.com.au/snakebite-and-your-pet. Boris was placed in hospital on frequent intravenous fluids to help flush his system of any toxicity or venom. We performed a urine test and an urgent blood test. With these results we were able to confirm that Boris had been bitten by a snake by testing his muscle enzyme (CK) count. The count was high which indicated that muscle damage had occurred - a symptom of snake bite venom.. Boris ...

Acervo Digital: Molecular cloning and biochemical characterization of a myotoxin inhibitor from Bothrops alternatus snake plasmaAcervo Digital: Molecular cloning and biochemical characterization of a myotoxin inhibitor from Bothrops alternatus snake plasma

Molecular cloning and biochemical characterization of a myotoxin inhibitor from Bothrops alternatus snake plasma. Author(s): * ... Phospholipases A(2) (PLA(2)s) are important components of Bothrops snake venoms, that can induce several effects on ... An inhibitory protein that neutralizes the enzymatic and toxic activities of several PLA2s from Bothrops venoms was isolated ... from Bothrops alternatus snake plasma by affinity chromatography using the immobilized myotoxin BthTX-I on CNBr-activated ...
more infohttps://acervodigital.unesp.br/handle/11449/17716

Perfil eletroforético das proteínas séricas de serpentes Crotalus durissus terrificus (cascavel) criadas em cativeiro | Portal...Perfil eletroforético das proteínas séricas de serpentes Crotalus durissus terrificus (cascavel) criadas em cativeiro | Portal...

The poisonous snakes of the genera Crotalus and Bothrops have been kept in captivity with the purpose of extracting poison for ... As serpentes peçonhentas dos gêneros Bothrops e Crotalus têm sido mantidas em cativeiro visando à extração de venenos para a ...
more infohttps://pesquisa.bvsalud.org/bvs-vet/resource/pt/vti-560

Bothrops - WikipediaBothrops - Wikipedia

Bothrops is a genus of pit vipers endemic to Central and South America. The generic name, Bothrops, is derived from the Greek ... Video of Bothrops jararacussu on YouTube. Accessed 6 December 2007. Video of Bothrops moojeni on YouTube. Accessed 6 December ... List of crotaline species and subspecies Bothrops by common name Bothrops by taxonomic synonyms Crotalinae by common name ... Bothrops at the Reptarium.cz Reptile Database. Accessed 6 December 2007. Video of Bothrops jararacussu on YouTube. Accessed 6 ...
more infohttps://en.wikipedia.org/wiki/Bothrops

Bothrops andianus - WikipediaBothrops andianus - Wikipedia

altitude" (2,743-3,048 m). List of crotaline species and subspecies Bothrops by common name Bothrops by taxonomic synonyms ... Bothrops andianus is a venomous pitviper species endemic to the Andes in South America. No subspecies are currently recognized ... "Bothrops andiana sp. nov.", pp. 103-105). Bothrocophias andianus at the Reptarium.cz Reptile Database. Accessed 12 August 2008. ... ISBN 0-8014-4141-2. "Bothrops andianus". Integrated Taxonomic Information System. Retrieved 12 August 2008. Amaral, Afranio. ...
more infohttps://en.wikipedia.org/wiki/Bothrops_andianus

Bothrops ammodytoides - WikispeciesBothrops ammodytoides - Wikispecies

Retrieved from "https://species.wikimedia.org/w/index.php?title=Bothrops_ammodytoides&oldid=2817808" ...
more infohttps://species.wikimedia.org/wiki/Bothrops_ammodytoides

Bradykinin-Potentiating Peptides from the Venom of Bothrops Jararaca | SpringerLinkBradykinin-Potentiating Peptides from the Venom of Bothrops Jararaca | SpringerLink

Greene L.J., Stewart J.M., Ferreira S.H. (1970) Bradykinin-Potentiating Peptides from the Venom of Bothrops Jararaca. In: ... In this communication we describe the isolation of nine biologically active peptides from Bothrops jararaca venom, present the ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4684-3198-8_11

Bothrops brazili Amaral, 1923Bothrops brazili Amaral, 1923

Bothrops species Bothrops brazili Name. Synonyms. Bothrops neglectus Amaral, 1923. Homonyms. Bothrops brazili Amaral, 1923. ... Bothrops brazili Amaral, 1923 Dataset GBIF Backbone Taxonomy Rank SPECIES Classification. kingdom Animalia phylum Chordata ... Hoge,A.R. (1954) A new Bothrops from Brazil - Bothrops brazili, sp. nov.: Mem. Inst. Butantan 25: 15-21 [1953] ... Bothrops brazili Hoge, 1954. Common names. Brazils Lancehead in English. Bibliographic References. * Amaral,A. do (1923) New ...
more infohttps://www.gbif.org/species/5220810

Snaclec aspercetin subunit beta - Bothrops asper (Terciopelo)Snaclec aspercetin subunit beta - Bothrops asper (Terciopelo)

"Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces ... "Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces ... "Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces ... sp,P0DJC9,SLB_BOTAS Snaclec aspercetin subunit beta (Fragment) OS=Bothrops asper OX=8722 PE=1 SV=1 ...
more infohttps://www.uniprot.org/uniprot/P0DJC9

Bradykinin-potentiating peptide 11g - Bothrops jararaca (Jararaca)Bradykinin-potentiating peptide 11g - Bothrops jararaca (Jararaca)

"Peptidomics of three Bothrops snake venoms: insights into the molecular diversification of proteomes and peptidomes.". Tashima ... "Peptidomics of three Bothrops snake venoms: insights into the molecular diversification of proteomes and peptidomes.". Tashima ... "Peptidomics of three Bothrops snake venoms: insights into the molecular diversification of proteomes and peptidomes.". Tashima ... Bothrops jararaca (Jararaca) (Bothrops jajaraca). ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_ ...
more infohttps://www.uniprot.org/uniprot/P0DL01

Cytokine profile of Ehrlich ascites tumor treated with Bothrops jararaca venomCytokine profile of Ehrlich ascites tumor treated with Bothrops jararaca venom

... Reinaldo J. da Silva,1 Márcia G. da Silva,2 ... "Cytokine profile of Ehrlich ascites tumor treated with Bothrops jararaca venom," Mediators of Inflammation, vol. 11, no. 4, pp ...
more infohttps://www.hindawi.com/journals/mi/2002/932828/cta/

Local haemorrhage induced by Bothrops jararaca venom: relationship to neurogenic inflammationLocal haemorrhage induced by Bothrops jararaca venom: relationship to neurogenic inflammation

... Luis Roberto C. Gonçalves1 and ... We investigated morphological alterations induced by s.c. injection of 2.5 μg of Bothrops jararaca venom in rats. Intense ... These data suggest that local haemorrhage induced by Bothrops jararaca venom is partially controlled by serotonin and ...
more infohttps://www.hindawi.com/journals/mi/2000/450741/abs/

Jararhagin, a hemorrhagic snake venom metalloproteinase from Bothrops jararaca.Jararhagin, a hemorrhagic snake venom metalloproteinase from Bothrops jararaca.

Jararhagin is a metalloproteinase isolated from Bothrops jararaca snake venom, which has been extensively studied. These ... Jararhagin is a metalloproteinase isolated from Bothrops jararaca snake venom, which has been extensively studied. These ...
more infohttp://www.biomedsearch.com/nih/Jararhagin-hemorrhagic-snake-venom-metalloproteinase/22534074.html

Morfologia dos fotorreceptores e genética dos pigmentos visuais de Bothrops jararaca...Morfologia dos fotorreceptores e genética dos pigmentos visuais de Bothrops jararaca...

Morfologia dos fotorreceptores e genética dos pigmentos visuais de Bothrops jararaca e Crotalus durissus terrificus (Serpentes ... Bothrops jararaca e Crotalus durissus terrificus. Três indivíduos de cada espécie foram obtidos junto ao laboratório de ... Bothrops jararaca and Crotalus durissus terrificus. Three subjects of each species were collected at the Butantan Institute. ...
more infohttp://www.teses.usp.br/teses/disponiveis/47/47132/tde-24012019-150846/pt-br.php

L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis. | Sigma-AldrichL-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis. | Sigma-Aldrich

L-Aminoacid Oxidase from Bothrops leucurus Venom Induces Nephrotoxicity via Apoptosis and Necrosis.. [Isabel C O Morais, ... Acute renal failure is a common complication caused by Bothrops viper envenomation. In this study, the nefrotoxicity of a main ...
more infohttps://www.sigmaaldrich.com/catalog/papers/26193352

Bothrops jararacussu venom-induced neuromuscular blockade inhibited by Casearia gossypiosperma Briquet hydroalcoholic extractBothrops jararacussu venom-induced neuromuscular blockade inhibited by Casearia gossypiosperma Briquet hydroalcoholic extract

Bothrops venom. Crude venom was obtained from adult Bothrops jararacussu (Bjssu) snakes (Serpentarium of the Nature Study ... In vivo myotoxic effects and in vitro irreversible neuromuscular blockade effects of crude venom from the snake Bothrops ... Rodrigues-Simioni L, Borgese N, Ceccarelli B. The effects of Bothrops jararacussu venom and its components on frog nerve-muscle ... Neutralization of the neuromuscular activity of bothropstoxin-I, a myotoxin from Bothrops jararacussu snake venom, by a ...
more infohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000300009&lng=pt&nrm=iso&tlng=en

Efeitos de toxinas com estrutura de fosfolipase A2, isoladas do veneno de Bothrops...Efeitos de toxinas com estrutura de fosfolipase A2, isoladas do veneno de Bothrops...

... isoladas de Bothrops asper (VBa) e CB2, de Crotalus durissus terrificus (VCdt) e os venenos brutos, sobre a expressão de ... Efeitos de toxinas com estrutura de fosfolipase A2, isoladas do veneno de Bothrops asper e Crotalus durissus terrificus, e dos ... A ação de fosfolipases A2 (FLA2s): miotoxinas (MTs) ?II e III, isoladas de Bothrops asper (VBa) e CB2, de Crotalus durissus ... Action of the phospholipase A2 (PLA22): myotoxins (MTs) -II and -III, from Bothrops asper (BaV) and CB2, from Crotalus durissus ...
more infohttp://www.teses.usp.br/teses/disponiveis/42/42136/tde-07112007-150546/pt-br.php

Bothrops lutzi | The Reptile DatabaseBothrops lutzi | The Reptile Database

Bothrops iglesiasi - RODRIGUES 2003. Bothrops lutzi - SILVA in CAMPBELL & LAMAR 2004. Bothrops lutzi - JANSEN 2008. Bothrops ... Bothrops iglesiasi - PETERS et al. 1970: 46. Bothrops neuwiedi lutzi - PETERS & OREJAS-MIRANDA 1970: 50. Bothrops iglesiasi - ... Bothrops neuwiedi lutzi - AMARAL 1929: 238. Bothrops neuwiedi lutzi HOGE 1966 [1965]: 128. Bothrops neuwiedi piauhyensis HOGE ... Bothrops iglesiasi AMARAL 1923: 97. Bothrops neuwiedi bahiensis AMARAL 1925: 57. Bothrops neuwiedi piauhyensis AMARAL 1925: 58 ...
more infohttp://reptile-database.reptarium.cz/species?genus=Bothrops&species=lutzi&search_param=%28%28taxon%3D%27Viperidae%27%29%29

Bothrops diporus | The Reptile DatabaseBothrops diporus | The Reptile Database

Bothrops diporus - SILVA in CAMPBELL & LAMAR 2004. Bothrops diporus - TRUTNAU 2008. Bothrops diporus - DA SILVA & RODRIGUES ... Bothrops neuwiedi diporus PETERS & OREJAS-MIRANDA 1970: 50. Bothrops neuwiedi diporus - CEI 1993. Bothrops neuwiedi diporus - ... Bothrops neuwiedi meridionalis AMARAL 1930: 66 (preoccupied). Bothrops neuwiedi diporus - COCHRAN 1961: 151. Bothrops neuwiedi ... Bothrops diporus COPE 1862: 347. Bothrops diporus - BOULENGER 1886: 438. Lachesis neuwiedi BOULENGER 1896 (part.). Lachesis ...
more infohttp://reptile-database.reptarium.cz/species?genus=Bothrops&species=diporus

NPP-BJ, a nucleotide pyrophosphatase/phosphodiesterase from Bothrops jararaca snake venom, inhibits platelet aggregation. |...NPP-BJ, a nucleotide pyrophosphatase/phosphodiesterase from Bothrops jararaca snake venom, inhibits platelet aggregation. |...

Here we describe for the first time the isolation and functional characterization of a soluble phosphodiesterase from Bothrops ... NPP-BJ, a nucleotide pyrophosphatase/phosphodiesterase from Bothrops jararaca snake venom, inhibits platelet aggregation.. [ ...
more infohttps://www.sigmaaldrich.com/catalog/papers/19481561

Toxins | Free Full-Text | Isolation and Functional Characterization of an Acidic Myotoxic Phospholipase A2 from Colombian...Toxins | Free Full-Text | Isolation and Functional Characterization of an Acidic Myotoxic Phospholipase A2 from Colombian...

A new myotoxic acidic Asp49 PLA2 (BaCol PLA2) was isolated from Colombian Bothrops asper venom using reverse-phase high ... BaCol PLA2 showed structural homology with other acidic PLA2 isolated from Bothrops venoms, including a non-myotoxic PLA2 from ... are responsible for many clinical manifestations in envenomation by Bothrops snakes. ... Keywords: acidic myotoxic phospholipase A2; Bothrops asper; edema; myotoxicity; snake venom acidic myotoxic phospholipase A2; ...
more infohttp://www.mdpi.com/2072-6651/9/11/342

Biological characterization of Bothrops marajoensis snake venom - Library Publishing MediaBiological characterization of Bothrops marajoensis snake venom - Library Publishing Media

Biological characterization of Bothrops marajoensis snake venom. Walter LG Cavalcante †,¥ , Saraguaci Hernandez-Oliveira †, ... This study describe s the effects of Bothrops marajoensis venom (Marajó lancehead) on isolated neuromuscular preparations of ...
more infohttp://libpubmedia.co.uk/biological-characterization-of-bothrops-marajoensis-snake-venom/

Toxins | Free Full-Text | Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced...Toxins | Free Full-Text | Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced...

... and wild forms have previously been shown to inhibit some toxic activities of Bothrops asper snake venom if preincubated before ... Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: ... Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: ... "Extracts of Renealmia alpinia (Rottb.) MAAS Protect against Lethality and Systemic Hemorrhage Induced by Bothrops asper Venom: ...
more infohttp://www.mdpi.com/2072-6651/7/5/1532

OCCIPITAL INFARCTION REVEALED BY QUADRANOPSIA FOLLOWING SNAKEBITE BY BOTHROPS LANCEOLATUS | The American Journal of Tropical...OCCIPITAL INFARCTION REVEALED BY QUADRANOPSIA FOLLOWING SNAKEBITE BY BOTHROPS LANCEOLATUS | The American Journal of Tropical...

The patient, a 46-year-old man, was bitten on the right thumb by Bothrops lanceolatus. Treatment with a specific equine ... f OCCIPITAL INFARCTION REVEALED BY QUADRANOPSIA FOLLOWING SNAKEBITE BY BOTHROPS LANCEOLATUS * HAROLD MERLE1,*, ANGÉLIQUE DONNIO ... Multiple cerebral infarctions following a snakebite by Bothrops caribbaeus. Am J Trop Med Hyg 67 : 287-288. ... The patient, a 46-year-old man, was bitten on the right thumb by Bothrops lanceolatus. Treatment with a specific equine ...
more infohttp://www.ajtmh.org/content/journals/10.4269/ajtmh.2005.73.583

BOTHROPS LANCEOLATUS. - THE ENCYCLOPEDIA OF PURE MATERIA MEDICA By TIMOTHY F. ALLEN, A.M.,
M.D.BOTHROPS LANCEOLATUS. - THE ENCYCLOPEDIA OF PURE MATERIA MEDICA By TIMOTHY F. ALLEN, A.M., M.D.

BOTHROPS LANCEOLATUS.. B. lanceolatus, Wagler-Dumeril; synonyms, Coluber glaucus, Linn. Vipera c rulescens, Laurent; Coluber ...
more infohttp://www.homeoint.org/allen/b/both.htm
  • Hoge,A.R. (1954) A new Bothrops from Brazil - Bothrops brazili, sp. (gbif.org)