A specific species of bacteria, part of the BORRELIA BURGDORFERI GROUP, whose common name is Lyme disease spirochete.
Gram-negative helical bacteria, in the genus BORRELIA, that are the etiologic agents of LYME DISEASE. The group comprises many specific species including Borrelia afzelii, Borellia garinii, and BORRELIA BURGDORFERI proper. These spirochetes are generally transmitted by several species of ixodid ticks.
An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.
Infections with bacteria of the genus BORRELIA.
The largest genus of TICKS in the family IXODIDAE, containing over 200 species. Many infest humans and other mammals and several are vectors of diseases such as LYME DISEASE, tick-borne encephalitis (ENCEPHALITIS, TICK-BORNE), and KYASANUR FOREST DISEASE.
Blood-sucking acarid parasites of the order Ixodida comprising two families: the softbacked ticks (ARGASIDAE) and hardbacked ticks (IXODIDAE). Ticks are larger than their relatives, the MITES. They penetrate the skin of their host by means of highly specialized, hooked mouth parts and feed on its blood. Ticks attack all groups of terrestrial vertebrates. In humans they are responsible for many TICK-BORNE DISEASES, including the transmission of ROCKY MOUNTAIN SPOTTED FEVER; TULAREMIA; BABESIOSIS; AFRICAN SWINE FEVER; and RELAPSING FEVER. (From Barnes, Invertebrate Zoology, 5th ed, pp543-44)
Members of the class Arachnida, especially SPIDERS; SCORPIONS; MITES; and TICKS; which transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.
A genus of gram-negative, anaerobic, helical bacteria, various species of which produce RELAPSING FEVER in humans and other animals.
Proteins isolated from the outer membrane of Gram-negative bacteria.
A genus of the subfamily SIGMODONTINAE consisting of 49 species. Two of these are widely used in medical research. They are P. leucopus, or the white-footed mouse, and P. maniculatus, or the deer mouse.
Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.
A deep type of gyrate erythema that follows a bite by an ixodid tick; it is a stage-1 manifestation of LYME DISEASE. The site of the bite is characterized by a red papule that expands peripherally as a nonscaling, palpable band that clears centrally. This condition is often associated with systemic symptoms such as chills, fever, headache, malaise, nausea, vomiting, fatigue, backache, and stiff neck.
Substances elaborated by bacteria that have antigenic activity.
Vaccines or candidate vaccines used to prevent LYME DISEASE.
The immature stage in the life cycle of those orders of insects characterized by gradual metamorphosis, in which the young resemble the imago in general form of body, including compound eyes and external wings; also the 8-legged stage of mites and ticks that follows the first moult.
An acute infection characterized by recurrent episodes of PYREXIA alternating with asymptomatic intervals of apparent recovery. This condition is caused by SPIROCHETES of the genus BORRELIA. It is transmitted by the BITES of either the body louse (PEDICULUS humanus corporis), for which humans are the reservoir, or by soft ticks of the genus ORNITHODOROS, for which rodents and other animals are the principal reservoirs.
Infestations with soft-bodied (Argasidae) or hard-bodied (Ixodidae) ticks.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Nervous system infections caused by tick-borne spirochetes of the BORRELIA BURGDORFERI GROUP. The disease may affect elements of the central or peripheral nervous system in isolation or in combination. Common clinical manifestations include a lymphocytic meningitis, cranial neuropathy (most often a facial neuropathy), POLYRADICULOPATHY, and a mild loss of memory and other cognitive functions. Less often more extensive inflammation involving the central nervous system (encephalomyelitis) may occur. In the peripheral nervous system, B. burgdorferi infection is associated with mononeuritis multiplex and polyradiculoneuritis. (From J Neurol Sci 1998 Jan 8;153(2):182-91)
Deoxyribonucleic acid that makes up the genetic material of bacteria.
A protein with a molecular weight of 40,000 isolated from bacterial flagella. At appropriate pH and salt concentration, three flagellin monomers can spontaneously reaggregate to form structures which appear identical to intact flagella.
An order of slender, flexuous, helically coiled bacteria, with one or more complete turns in the helix.
Animate or inanimate sources which normally harbor disease-causing organisms and thus serve as potential sources of disease outbreaks. Reservoirs are distinguished from vectors (DISEASE VECTORS) and carriers, which are agents of disease transmission rather than continuing sources of potential disease outbreaks.
Proteins found in any species of bacterium.
Bacterial, viral, or parasitic diseases transmitted to humans and animals by the bite of infected ticks. The families Ixodidae and Argasidae contain many bloodsucking species that are important pests of man and domestic birds and mammals and probably exceed all other arthropods in the number and variety of disease agents they transmit. Many of the tick-borne diseases are zoonotic.
Arthritis caused by BACTERIA; RICKETTSIA; MYCOPLASMA; VIRUSES; FUNGI; or PARASITES.
A species of gram-negative bacteria in the genus ANAPLASMA, family ANAPLASMATACEAE, formerly called Ehrlichia phagocytophila or Ehrlichia equi. This organism is tick-borne (IXODES) and causes disease in horses and sheep. In humans, it causes human granulocytic EHRLICHIOSIS.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
An idiopathic disorder characterized by the loss of filiform papillae leaving reddened areas of circinate macules bound by a white band. The lesions heal, then others erupt.
A tick-borne disease characterized by FEVER; HEADACHE; myalgias; ANOREXIA; and occasionally RASH. It is caused by several bacterial species and can produce disease in DOGS; CATTLE; SHEEP; GOATS; HORSES; and humans. The primary species causing human disease are EHRLICHIA CHAFFEENSIS; ANAPLASMA PHAGOCYTOPHILUM; and Ehrlichia ewingii.
Arthropods, other than insects and arachnids, which transmit infective organisms from one host to another or from an inanimate reservoir to an animate host.
A species of protozoa infecting humans via the intermediate tick vector IXODES scapularis. The other hosts are the mouse PEROMYSCUS leucopus and meadow vole MICROTUS pennsylvanicus, which are fed on by the tick. Other primates can be experimentally infected with Babesia microti.
The functional hereditary units of BACTERIA.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Diagnostic procedures involving immunoglobulin reactions.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A mammalian order which consists of 29 families and many genera.
Small, often pleomorphic, coccoid to ellipsoidal organisms occurring intracytoplasmically in circulating LYMPHOCYTES. They are the etiologic agents of tick-borne diseases of humans; DOGS; CATTLE; SHEEP; GOATS; and HORSES.
A genus of tick-borne protozoan parasites that infests the red blood cells of mammals, including humans. There are many recognized species, and the distribution is world-wide.
The articulations between the various TARSAL BONES. This does not include the ANKLE JOINT which consists of the articulations between the TIBIA; FIBULA; and TALUS.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
Invertebrates or non-human vertebrates which transmit infective organisms from one host to another.
The intergenic DNA segments that are between the ribosomal RNA genes (internal transcribed spacers) and between the tandemly repeated units of rDNA (external transcribed spacers and nontranscribed spacers).
Inflammation involving the skin of the extremities, especially the hands and feet. Several forms are known, some idiopathic and some hereditary. The infantile form is called Gianotti-Crosti syndrome.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
A group of tick-borne diseases of mammals including ZOONOSES in humans. They are caused by protozoa of the genus BABESIA, which parasitize erythrocytes, producing hemolysis. In the U.S., the organism's natural host is mice and transmission is by the deer tick IXODES SCAPULARIS.
A family of hardbacked TICKS, in the subclass ACARI. Genera include DERMACENTOR and IXODES among others.
COUMARINS with an amino group, exemplified by NOVOBIOCIN.
An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).
Also known as articulations, these are points of connection between the ends of certain separate bones, or where the borders of other bones are juxtaposed.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Endogenous proteins that inhibit or inactivate COMPLEMENT C3B. They include COMPLEMENT FACTOR H and COMPLEMENT FACTOR I (C3b/C4b inactivator). They cleave or promote the cleavage of C3b into inactive fragments, and thus are important in the down-regulation of COMPLEMENT ACTIVATION and its cytolytic sequence.
The relationships of groups of organisms as reflected by their genetic makeup.
The science of developing, caring for, or cultivating forests.
A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.
A subfamily of the family MURIDAE comprised of 69 genera. New World mice and rats are included in this subfamily.
Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.
A widely distributed genus of TICKS, in the family IXODIDAE, including a number that infest humans and other mammals. Several are vectors of diseases such as TULAREMIA; ROCKY MOUNTAIN SPOTTED FEVER; COLORADO TICK FEVER; and ANAPLASMOSIS.
Created 1 January 1993 as a result of the division of Czechoslovakia into the Czech Republic and Slovakia.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.
A family of the order Rodentia containing 250 genera including the two genera Mus (MICE) and Rattus (RATS), from which the laboratory inbred strains are developed. The fifteen subfamilies are SIGMODONTINAE (New World mice and rats), CRICETINAE, Spalacinae, Myospalacinae, Lophiomyinae, ARVICOLINAE, Platacanthomyinae, Nesomyinae, Otomyinae, Rhizomyinae, GERBILLINAE, Dendromurinae, Cricetomyinae, MURINAE (Old World mice and rats), and Hydromyinae.
Change in the surface ANTIGEN of a microorganism. There are two different types. One is a phenomenon, especially associated with INFLUENZA VIRUSES, where they undergo spontaneous variation both as slow antigenic drift and sudden emergence of new strains (antigenic shift). The second type is when certain PARASITES, especially trypanosomes, PLASMODIUM, and BORRELIA, survive the immune response of the host by changing the surface coat (antigen switching). (From Herbert et al., The Dictionary of Immunology, 4th ed)
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
A synthetic tetracycline derivative with similar antimicrobial activity.
The family Cervidae of 17 genera and 45 species occurring nearly throughout North America, South America, and Eurasia, on most associated continental islands, and in northern Africa. Wild populations of deer have been established through introduction by people in Cuba, New Guinea, Australia, New Zealand, and other places where the family does not naturally occur. They are slim, long-legged and best characterized by the presence of antlers. Their habitat is forests, swamps, brush country, deserts, and arctic tundra. They are usually good swimmers; some migrate seasonally. (Walker's Mammals of the World, 5th ed, p1362)
Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
A whiplike motility appendage present on the surface cells. Prokaryote flagella are composed of a protein called FLAGELLIN. Bacteria can have a single flagellum, a tuft at one pole, or multiple flagella covering the entire surface. In eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella have the same basic structure as CILIA but are longer in proportion to the cell bearing them and present in much smaller numbers. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
A DNA-directed RNA polymerase found in BACTERIA. It is a holoenzyme that consists of multiple subunits including sigma factor 54.
The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.
Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.
Constituent of 50S subunit of prokaryotic ribosomes containing about 3200 nucleotides. 23S rRNA is involved in the initiation of polypeptide synthesis.
Created 7 April 1992 as a result of the division of Yugoslavia.
Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).
Genotypic differences observed among individuals in a population.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.
A method for diagnosing a disease in one organism by inoculating the putative causative organism in a second animal of a different species. It has been used for the detection of parasites (Trypanosoma cruzi and Trichinella spiralis) when peripheral blood smears are negative. (Segen, Current Med Talk, 1995)
Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.
A protein which is a subunit of RNA polymerase. It effects initiation of specific RNA chains from DNA.
Organs and other anatomical structures of non-human vertebrate and invertebrate animals.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
The natural bactericidal property of BLOOD due to normally occurring antibacterial substances such as beta lysin, leukin, etc. This activity needs to be distinguished from the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy, which is measured by a SERUM BACTERICIDAL TEST.
A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.
A genus of softbacked TICKS, in the family ARGASIDAE, serving as the vector of BORRELIA, causing RELAPSING FEVER, and of the AFRICAN SWINE FEVER VIRUS.
Porins are protein molecules that were originally found in the outer membrane of GRAM-NEGATIVE BACTERIA and that form multi-meric channels for the passive DIFFUSION of WATER; IONS; or other small molecules. Porins are present in bacterial CELL WALLS, as well as in plant, fungal, mammalian and other vertebrate CELL MEMBRANES and MITOCHONDRIAL MEMBRANES.
Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)
A subfamily of MURIDAE found nearly world-wide and consisting of about 20 genera. Voles, lemmings, and muskrats are members.
Proteins prepared by recombinant DNA technology.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
A family of the order Rodentia which contains 49 genera. Some of the more common genera are MARMOTA, which includes the marmot and woodchuck; Sciurus, the gray squirrel, S. carolinensis, and the fox squirrel, S. niger; Tamias, the eastern and western chipmunk; and Tamiasciurus, the red squirrel. The flying squirrels, except the scaly-tailed Anomaluridae, also belong to this family.
Constituent of the 50S subunit of prokaryotic ribosomes containing about 120 nucleotides and 34 proteins. It is also a constituent of the 60S subunit of eukaryotic ribosomes. 5S rRNA is involved in initiation of polypeptide synthesis.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Substances that reduce the growth or reproduction of BACTERIA.
A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.
Species of gram-negative bacteria in the family ANAPLASMATACEAE, causing EHRLICHIOSIS in DOGS. The most common vector is the brown dog tick. It can also cause disease in humans.
The causative agent of venereal and non-venereal syphilis as well as yaws.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
A family of bacteria which inhabit RED BLOOD CELLS and cause several animal diseases.
Animals considered to be wild or feral or not adapted for domestic use. It does not include wild animals in zoos for which ANIMALS, ZOO is available.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
The hearing and equilibrium system of the body. It consists of three parts: the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR. Sound waves are transmitted through this organ where vibration is transduced to nerve signals that pass through the ACOUSTIC NERVE to the CENTRAL NERVOUS SYSTEM. The inner ear also contains the vestibular organ that maintains equilibrium by transducing signals to the VESTIBULAR NERVE.
Structures within the nucleus of bacterial cells consisting of or containing DNA, which carry genetic information essential to the cell.
The genetic complement of a BACTERIA as represented in its DNA.
Measurable quantity of bacteria in an object, organism, or organism compartment.
Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of causes.
Antibodies produced by a single clone of cells.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
Created 1 January 1993 as a result of the division of Czechoslovakia into the Czech Republic and Slovakia.
Ability of a microbe to survive under given conditions. This can also be related to a colony's ability to replicate.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The geographic area of New England in general and when the specific state or states are not indicated. States usually included in this region are Maine, New Hampshire, Vermont, Massachusetts, Connecticut, and Rhode Island.

Four clones of Borrelia burgdorferi sensu stricto cause invasive infection in humans. (1/1041)

Lyme disease begins at the site of a tick bite, producing a primary infection with spread of the organism to secondary sites occurring early in the course of infection. A major outer surface protein expressed by the spirochete early in infection is outer surface protein C (OspC). In Borrelia burgdorferi sensu stricto, OspC is highly variable. Based on sequence divergence, alleles of ospC can be divided into 21 major groups. To assess whether strain differences defined by ospC group are linked to invasiveness and pathogenicity, we compared the frequency distributions of major ospC groups from ticks, from the primary erythema migrans skin lesion, and from secondary sites, principally from blood and spinal fluid. The frequency distribution of ospC groups from ticks is significantly different from that from primary sites, which in turn is significantly different from that from secondary sites. The major groups A, B, I, and K had higher frequencies in the primary sites than in ticks and were the only groups found in secondary sites. We define three categories of major ospC groups: one that is common in ticks but very rarely if ever causes human disease, a second that causes only local infection at the tick bite site, and a third that causes systemic disease. The finding that all systemic B. burgdorferi sensu stricto infections are associated with four ospC groups has importance in the diagnosis, treatment, and prevention of Lyme disease.  (+info)

Detection of Borrelia burgdorferi sensu stricto by reverse line blot in the joints of Dutch patients with Lyme arthritis. (2/1041)

OBJECTIVE: To analyze the presence of Borrelia burgdorferi sensu lato in synovial samples from the knee joint of patients with Lyme arthritis by polymerase chain reaction, and to differentiate the species by reverse line blot (RLB). METHODS: Synovial fluid (SF) and synovial tissue (ST) samples were obtained from patients with Lyme arthritis (n = 4) and from patients with various other forms of arthritis (n = 9). DNA extracted from synovial samples was amplified by using, as a target, the spacer region between the 5S and 23S ribosomal RNA genes of B. burgdorferi sensu lato. Subsequently, 4 species-specific DNA probes were used in the RLB for specific hybridization. RESULTS: DNA from B. burgdorferi sensu stricto DNA was detected in the SF and ST from 3 patients with Lyme arthritis. B. burgdorferi sensu lato DNA was not detected in the synovial samples from 9 control patients. CONCLUSION: The relationship between different species of B. burgdorferi sensu lato and arthritis can be studied using direct analysis of extracted DNA from joint samples. This method can be used to study the association between particular clinical manifestations of Lyme disease and different species of B. burgdorferi sensu lato.  (+info)

Scored antibody reactivity determined by immunoblotting shows an association between clinical manifestations and presence of Borrelia burgdorferi sensu stricto, B. garinii, B. afzelii, and B. Valaisiana in humans. (3/1041)

An immunoglobulin G immunoblot was developed with antigenic extracts of Borrelia burgdorferi sensu stricto, B. garinii, B. afzelii, and B. valaisiana genospecies and was reacted with sera from patients with neuroborreliosis, acrodermatitis, and Lyme arthritis. A detailed analysis of the reactivities of the protein bands was performed, and a two-step scoring procedure was selected to determine the preferential reactivity of sera to one particular genospecies. The discriminative potential of 5 proteins (12-kDa, 16-kDa, 18-kDa, OspA, and 66-kDa proteins) was used as a rapid first-step scoring method, followed by scoring of 14 additional protein bands if necessary. The advantage of this procedure is the low percentage of serum samples with inconclusive results for one of the four species (10% for patients with neuroborreliosis, 6% for patients with acrodermatitis chronica atrophicans, and 6% for patients with Lyme arthritis). Among 31 serum samples from patients with neuroborreliosis, 16 were more reactive to B. garinii, 7 were more reactive to B. afzelii, 3 were more reactive to B. valaisiana, and 2 were more reactive to B. burgdorferi sensu stricto. Of 31 serum samples from patients with acrodermatitis, 26 showed a higher level of reactivity to B. afzelii. Of 34 serum samples from patients with Lyme arthritis, 21 were more reactive to B. burgdorferi sensu stricto, 10 were more reactive to B. afzelii, and 1 was more reactive to B. valaisiana. Our results suggest an organotropism of Borrelia species and provide some evidence of a pathogenic potential of B. valaisiana in humans.  (+info)

Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice. (4/1041)

The Lyme disease-associated spirochete, Borrelia burgdorferi, is maintained in enzootic cycles involving Ixodes ticks and small mammals. Previous studies demonstrated that B. burgdorferi expresses outer surface protein A (OspA) but not OspC when residing in the midgut of unfed ticks. However, after ticks feed on blood, some spirochetes stop making OspA and express OspC. Our current work examined the timing and frequency of OspA and OspC expression by B. burgdorferi in infected Ixodes scapularis nymphs as they fed on uninfected mice and in uninfected I. scapularis larvae and nymphs as they first acquired spirochetes from infected mice. Smears of midguts from previously infected ticks were prepared at 12- or 24-h intervals following attachment through repletion at 96 h, and spirochetes were stained for immunofluorescence for detection of antibodies to OspA and OspC. As shown previously, prior to feeding spirochetes in nymphs expressed OspA but not OspC. During nymphal feeding, however, the proportion of spirochetes expressing OspA decreased, while spirochetes expressing OspC became detectable. In fact, spirochetes rapidly began to express OspC, with the greatest proportion of spirochetes having this protein at 48 h of attachment and then with the proportion decreasing significantly by the time that the ticks had completed feeding. In vitro cultivation of the spirochete at different temperatures showed OspC to be most abundant when the spirochetes were grown at 37 degrees C. Yet, the synthesis of this protein waned with continuous passage at this temperature. Immunofluorescence staining of spirochetes in smears of midguts from larvae and nymphs still attached or having completed feeding on infected mice demonstrated that OspA but not OspC was produced by these spirochetes recently acquired from mice. Therefore, the temporal synthesis of OspC by spirochetes only in feeding ticks that were infected prior to the blood meal suggests that this surface protein is involved in transmission from tick to mammal but not from mammal to tick.  (+info)

The relapsing fever spirochete Borrelia hermsii contains multiple, antigen-encoding circular plasmids that are homologous to the cp32 plasmids of Lyme disease spirochetes. (5/1041)

Borrelia hermsii, an agent of tick-borne relapsing fever, was found to contain multiple circular plasmids approximately 30 kb in size. Sequencing of a DNA library constructed from circular plasmid fragments enabled assembly of a composite DNA sequence that is homologous to the cp32 plasmid family of the Lyme disease spirochete, B. burgdorferi. Analysis of another relapsing fever bacterium, B. parkeri, indicated that it contains linear homologs of the B. hermsii and B. burgdorferi cp32 plasmids. The B. hermsii cp32 plasmids encode homologs of the B. burgdorferi Mlp and Bdr antigenic proteins and BlyA/BlyB putative hemolysins, but homologs of B. burgdorferi erp genes were absent. Immunoblot analyses demonstrated that relapsing fever patients produced antibodies to Mlp proteins, indicating that those proteins are synthesized by the spirochetes during human infection. Conservation of cp32-encoded genes in different Borrelia species suggests that their protein products serve functions essential to both relapsing fever and Lyme disease spirochetes. Relapsing fever borreliae replicate to high levels in the blood of infected animals, permitting direct detection and possible functional studies of Mlp, Bdr, BlyA/BlyB, and other cp32-encoded proteins in vivo.  (+info)

Rapid differentiation of Borrelia garinii from Borrelia afzelii and Borrelia burgdorferi sensu stricto by LightCycler fluorescence melting curve analysis of a PCR product of the recA gene. (6/1041)

To differentiate the Borrelia burgdorferi sensu lato genospecies, LightCycler real-time PCR was used for the fluorescence (SYBR Green I) melting curve analysis of borrelial recA gene PCR products. The specific melting temperature analyzed is a function of the GC/AT ratio, length, and nucleotide sequence of the amplified product. A total of 32 DNA samples were tested. Of them three were isolated from B. burgdorferi reference strains and 16 were isolated from B. burgdorferi strains cultured from Ixodes ricinus ticks; 13 were directly isolated from nine human biopsy specimens and four I. ricinus tick midguts. The melting temperature of B. garinii was 2 degrees C lower than that of B. burgdorferi sensu stricto and B. afzelii. Melting curve analysis offers a rapid alternative for identification and detection of B. burgdorferi sensu lato genospecies.  (+info)

Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi. (7/1041)

Outer surface protein C (OspC) is a major antigen on the surface of the Lyme disease spirochete, Borrelia burgdorferi, when it is being transmitted to humans. Crystal structures of OspC have been determined for strains HB19 and B31 to 1.8 and 2.5 A resolution, respectively. The three-dimensional structure is predominantly helical. This is in contrast to the structure of OspA, a major surface protein mainly present when spirochetes are residing in the midgut of unfed ticks, which is mostly beta-sheet. The surface of OspC that would project away from the spirochete's membrane has a region of strong negative electrostatic potential which may be involved in binding to positively charged host ligands. This feature is present only on OspCs from strains known to cause invasive human disease.  (+info)

Impact of genotypic variation of Borrelia burgdorferi sensu stricto on kinetics of dissemination and severity of disease in C3H/HeJ mice. (8/1041)

Various genotypes of Borrelia burgdorferi sensu stricto have been previously identified among a large collection of isolates cultured from patients with Lyme disease in the United States. Furthermore, association of specific genotypes with hematogenous dissemination early in the disease course has been observed. The present study assessed kinetics of spirochete dissemination and disease severity in C3H/HeJ mice infected with two different genotypes of B. burgdorferi. Spirochete load in plasma and ear and other tissue samples of infected mice was measured by quantitative PCR, and these data were compared to those obtained by culture and histopathologic analysis. In mice infected with isolate BL206 (a type 1 strain), the peak number of spirochetes was observed in plasma between day 4 and 7, in heart and ear tissue on day 14, and in joints on day 28 postinoculation. There was a correlation between the peak number of spirochetes in plasma on day 4 or 7 and that in ear biopsy and joint specimens on day 14. By contrast, spirochete burdens in plasma of mice infected with isolate B356 (a type 3 strain) were 16- and 5-fold lower than those of BL206-infected mice on days 7 and 14 of infection, respectively. Similarly, approximately 6- and 13-fold fewer spirochetes were detected in the heart tissues of B356-infected mice compared to BL206-infected mice. Histopathologically, severe arthritis and aortitis were noted only in mice infected with isolate BL206. Spirochete dissemination and disease severity vary significantly in mice infected with distinct genotypes of B. burgdorferi, suggesting that genotypic differences in the infecting spirochetes play a key role in the pathogenesis and development of clinical disease.  (+info)

Lyme disease is typically diagnosed based on a combination of physical symptoms, medical history, and laboratory tests. Treatment typically involves antibiotics, which can help to clear the infection and alleviate symptoms.

Prevention of Lyme disease involves protecting against tick bites by using insect repellents, wearing protective clothing when outdoors, and conducting regular tick checks. Early detection and treatment of Lyme disease can help to prevent long-term complications, such as joint inflammation and neurological problems.

In this definition, we have used technical terms such as 'bacterial infection', 'blacklegged tick', 'Borrelia burgdorferi', and 'antibiotics' to provide a more detailed understanding of the medical concept.

There are several types of Borrelia infections, including:

1. Lyme disease: This is the most common Borrelia infection, and it is caused by the bacterium Borrelia burgdorferi. It is transmitted through the bite of an infected blacklegged tick (Ixodes scapularis) and can cause symptoms such as fever, headache, and a distinctive rash called erythema migrans.
2. Babesiosis: This infection is caused by the bacterium Borrelia microti and is transmitted through the bite of an infected deer tick (Ixodes scapularis). It can cause symptoms such as fever, chills, and fatigue.
3. Anaplasmosis: This infection is caused by the bacterium Borrelia anaplasmataceae and is transmitted through the bite of an infected blacklegged tick (Ixodes scapularis). It can cause symptoms such as fever, headache, and muscle pain.
4. Relapsing fever: This infection is caused by the bacterium Borrelia hermsii and is transmitted through the bite of an infected soft tick (Ornithodoros mojavensis). It can cause symptoms such as fever, headache, and joint pain.

Borrelia infections can be diagnosed through a combination of physical examination, medical history, and laboratory tests, such as blood tests or polymerase chain reaction (PCR) assays. Treatment typically involves antibiotics, which can help to clear the infection and alleviate symptoms.

Prevention of Borrelia infections involves protecting against tick bites, such as using insect repellents, wearing protective clothing, and doing regular tick checks. It is also important to be aware of the risks of Borrelia infections in different regions and to take appropriate precautions when traveling or spending time outdoors.

Overall, while Borrelia infections can be serious and potentially life-threatening, they are treatable with antibiotics and preventable through awareness and protection against tick bites. It is important to seek medical attention if symptoms persist or worsen over time, as early treatment can help to improve outcomes.

The term "erythema chronicum migrans" is derived from the Latin words "erythema," meaning redness, and "chronicum," meaning long-lasting. The term "migrans" refers to the fact that the rash typically spreads or migrates over time. ECM is considered a hallmark symptom of Lyme disease and is often used as a diagnostic criterion for the condition.

The exact cause of ECM is not fully understood, but it is thought to be due to an immune response to the bacterial infection. Treatment for ECM typically involves antibiotics to eradicate the infection, and symptoms may resolve within several weeks of treatment. However, some patients may experience persistent symptoms or develop long-term complications, such as arthritis or neurological problems.

The symptoms of relapsing fever can vary depending on the severity of the infection, but may include:

* Fever (which can be quite high, often exceeding 104°F)
* Headache
* Muscle pain
* Joint pain
* Swollen lymph nodes
* Sore throat
* Rash
* Weakness and fatigue

The infection is typically diagnosed through a combination of physical examination, medical history, and laboratory tests such as blood cultures or PCR (polymerase chain reaction) tests.

Relapsing fever is treated with antibiotics, such as doxycycline or penicillin G. The infection can be cured with proper treatment, but without treatment, it can lead to complications such as meningitis, encephalitis, or death.

Prevention of relapsing fever includes avoiding tick bites, using protective clothing and insect repellents when outdoors in areas where the bacteria is found, and promptly seeking medical attention if symptoms develop.

Synonyms: tick bites, tick infestations, tick-borne illnesses, tick-transmitted diseases.

Antonyms: none.

Types of Tick Infestations:

1. Lyme disease: Caused by the bacterium Borrelia burgdorferi, which is transmitted through the bite of an infected blacklegged tick (Ixodes scapularis). Symptoms include fever, headache, and a distinctive skin rash.
2. Rocky Mountain spotted fever: Caused by the bacterium Rickettsia rickettsii, which is transmitted through the bite of an infected American dog tick (Dermacentor variabilis). Symptoms include fever, headache, and a rash with small purple spots.
3. Tick-borne relapsing fever: Caused by the bacterium Borrelia duttoni, which is transmitted through the bite of an infected soft tick (Ornithodoros moenia). Symptoms include fever, headache, and a rash with small purple spots.
4. Babesiosis: Caused by the parasite Babesia microti, which is transmitted through the bite of an infected blacklegged tick (Ixodes scapularis). Symptoms include fever, chills, and fatigue.
5. Anaplasmosis: Caused by the bacterium Anaplasma phagocytophilum, which is transmitted through the bite of an infected blacklegged tick (Ixodes scapularis). Symptoms include fever, headache, and muscle aches.

Causes and Risk Factors:

1. Exposure to ticks: The risk of developing tick-borne diseases is high in areas where ticks are common, such as wooded or grassy areas with long grass or leaf litter.
2. Warm weather: Ticks are most active during warm weather, especially in the spring and summer months.
3. Outdoor activities: People who engage in outdoor activities, such as hiking, camping, or gardening, are at higher risk of exposure to ticks.
4. Poor tick awareness: Not knowing how to protect yourself from ticks or not being aware of the risks of tick-borne diseases can increase your likelihood of getting sick.
5. Lack of tick prevention measures: Failing to use tick repellents, wear protective clothing, or perform regular tick checks can increase your risk of exposure to ticks and tick-borne diseases.

Prevention and Treatment:

1. Tick awareness: Learn how to identify ticks, the risks of tick-borne diseases, and how to protect yourself from ticks.
2. Use tick repellents: Apply tick repellents to your skin and clothing before going outdoors, especially in areas where ticks are common.
3. Wear protective clothing: Wear long sleeves, pants, and closed-toe shoes to cover your skin and make it harder for ticks to attach to you.
4. Perform regular tick checks: Check yourself, children, and pets frequently for ticks when returning indoors, especially after spending time outdoors in areas where ticks are common.
5. Remove attached ticks: If you find a tick on your body, remove it promptly and correctly to reduce the risk of infection.
6. Use permethrin-treated clothing and gear: Treating your clothing and gear with permethrin can help repel ticks and reduce the risk of infection.
7. Vaccination: There are vaccines available for some tick-borne diseases, such as Lyme disease, which can help protect against these illnesses.
8. Early treatment: If you suspect that you have been bitten by a tick and develop symptoms of a tick-borne disease, seek medical attention promptly. Early treatment can help prevent long-term complications and improve outcomes.

It's important to note that not all ticks carry diseases, but it's always better to be safe than sorry. By following these tips, you can reduce your risk of tick bites and the potential for tick-borne illnesses.

1. Meningitis: Inflammation of the membranes surrounding the brain and spinal cord.
2. Encephalitis: Inflammation of the brain tissue.
3. Cranial neuritis: Inflammation of the nerves in the head.
4. Radiculoneuritis: Inflammation of the nerves in the spine.
5. Peripheral neuropathy: Damage to the nerves outside of the CNS.

Lyme neuroborreliosis can be difficult to diagnose, as it may mimic other conditions such as multiple sclerosis or Bell's palsy. Diagnosis is typically based on a combination of clinical evaluation, laboratory tests, and imaging studies. Treatment usually involves antibiotics, and early recognition and intervention are important to prevent long-term neurological damage.

Symptoms of Lyme neuroborreliosis can vary depending on the stage of the disease and the severity of the infection. They may include:

1. Fever, headache, and neck stiffness
2. Confusion, seizures, or loss of consciousness
3. Weakness, numbness, or paralysis in the limbs
4. Pain or tingling sensations in the arms and legs
5. Difficulty with speech, vision, or hearing
6. Incoordination or difficulty walking
7. Balance problems or dizziness
8. Memory loss or difficulty concentrating
9. Mood changes, such as depression or anxiety
10. Sleep disturbances

It is important to note that some people may experience long-term neurological symptoms after treatment for Lyme disease, known as post-treatment Lyme disease syndrome (PTLDS). This condition is not well understood and may be due to a variety of factors, including persistent infection, autoimmune responses, or inflammation.

The diagnosis of Lyme neuroborreliosis can be challenging, as the symptoms can be similar to those of other conditions such as meningitis or encephalitis. Laboratory tests may include blood tests to detect antibodies against the bacteria, as well as spinal fluid testing to rule out other conditions. Imaging studies such as CT or MRI scans may also be used to support the diagnosis.

Treatment of Lyme neuroborreliosis typically involves antibiotics, which can help to clear the infection and alleviate symptoms. In severe cases, hospitalization may be necessary to manage complications such as seizures or muscle weakness. Early recognition and treatment are important to prevent long-term neurological damage.

Prevention is key to avoiding Lyme neuroborreliosis, and this involves protecting against tick bites. Some ways to do this include:

1. Wearing protective clothing such as long sleeves and pants when outdoors in tick-prone areas
2. Using insect repellents that contain DEET or picaridin on exposed skin and clothing
3. Conducting regular tick checks on oneself, children, and pets after spending time outdoors
4. Avoiding areas with high grass and leaf litter, where ticks are more likely to be found
5. Using permethrin-treated clothing and gear to reduce the risk of tick bites.

Overall, Lyme neuroborreliosis is a serious condition that can have long-lasting effects on the nervous system if left untreated. Early recognition and treatment are crucial to preventing complications and improving outcomes for patients with this condition.

Some common tick-borne diseases include:

1. Lyme disease: This is the most common tick-borne disease in the United States, and it is caused by the bacterium Borrelia burgdorferi. It can cause symptoms such as fever, headache, and a distinctive rash, and if left untreated, can lead to joint pain, swelling, and long-term health problems.
2. Rocky Mountain spotted fever: This is a tick-borne disease caused by the bacterium Rickettsia rickettsii, and it can cause symptoms such as fever, headache, and a rash with tiny red spots. It can be severe and even life-threatening if left untreated.
3. Babesiosis: This is a tick-borne disease caused by the parasite Babesia, and it can cause symptoms such as fever, chills, and fatigue. It can be particularly dangerous for people with weakened immune systems, such as the elderly or those with chronic illnesses.
4. Anaplasmosis: This is a tick-borne disease caused by the bacterium Anaplasma, and it can cause symptoms such as fever, headache, and muscle pain. It can be severe and even life-threatening if left untreated.
5. Powassan virus disease: This is a rare tick-borne disease caused by the Powassan virus, and it can cause symptoms such as fever, headache, and confusion. It can be severe and even life-threatening if left untreated.

Prevention of tick-borne diseases includes protecting against tick bites by using insect repellents, wearing protective clothing, and doing regular tick checks. Early detection and treatment of tick-borne diseases can help prevent complications and improve outcomes.

A type of arthritis that is caused by an infection in the joint, typically bacterial or viral. The most common form of infectious arthritis is Lyme disease, which is caused by the bacterium Borrelia burgdorferi and is transmitted through the bite of an infected blacklegged tick. Other types of infectious arthritis include septic arthritis (caused by bacterial infection) and reactive arthritis (caused by a bacterial or viral infection in another part of the body).

Symptoms: Pain, swelling, redness, warmth, and limited range of motion in the affected joint. Fever may also be present.

Diagnosis: A diagnosis is made based on symptoms, physical examination, blood tests (such as a complete blood count or a polymerase chain reaction test to detect the presence of bacteria or viruses), and imaging studies (such as X-rays or ultrasound).

Treatment: Treatment typically involves antibiotics to eradicate the infection, as well as medication to manage symptoms such as pain and inflammation. In severe cases, surgery may be necessary to repair damaged tissue or joints.

Symptoms of glossitis, benign migratory include:

Painful patches on the tongue that come and go
Difficulty speaking or eating due to discomfort
Tongue appears to have a map-like pattern with different areas having different textures
Burning sensation in the mouth
Redness and swelling of the tongue
The condition is diagnosed based on the appearance of the tongue and the patient's symptoms. Treatment options include avoiding trigger foods, practicing good oral hygiene, using topical anesthetics or anti-inflammatory medications, and in severe cases, corticosteroid therapy.

While the condition is not serious, it can cause significant discomfort and affect quality of life. Therefore, if you experience symptoms of glossitis, benign migratory, it is essential to seek medical attention from a healthcare professional for proper diagnosis and treatment.

Symptoms of ehrlichiosis typically begin within one to two weeks after the tick bite and may include fever, headache, muscle pain, joint pain, and rash. In severe cases, the infection can spread to the bloodstream and cause more serious complications, such as respiratory distress, liver failure, and kidney failure.

Ehrlichiosis is diagnosed through a combination of physical examination, medical history, and laboratory tests, including a polymerase chain reaction (PCR) test to detect the bacterial DNA in the blood. Treatment typically involves antibiotics, such as doxycycline or azithromycin, which are effective against the bacteria that cause ehrlichiosis.

Prevention of ehrlichiosis primarily involves avoiding tick habitats and using tick-repellent clothing and insecticides to prevent tick bites. Early detection and treatment of ehrlichiosis can help reduce the risk of serious complications and improve outcomes for infected individuals.

Here are some common types of bites and stings and their symptoms:

1. Insect bites: These can cause redness, swelling, itching, and pain at the site of the bite. Some people may experience an allergic reaction to insect venom, which can be severe and potentially life-threatening. Common insect bites include mosquito bites, bee stings, wasp stings, hornet stings, and fire ant bites.
2. Spider bites: Spiders can also cause a range of symptoms, including redness, swelling, pain, and itching. Some spider bites can be serious and require medical attention, such as the black widow spider bite or the brown recluse spider bite. These bites can cause necrotic lesions, muscle cramps, and breathing difficulties.
3. Animal bites: Animal bites can be serious and can cause infection, swelling, pain, and scarring. Rabies is a potential risk with animal bites, especially if the animal is not up to date on its vaccinations. Common animal bites include dog bites, cat bites, and bat bites.
4. Allergic reactions: Some people may experience an allergic reaction to insect or animal bites or stings, which can be severe and potentially life-threatening. Symptoms of an allergic reaction include hives, itching, difficulty breathing, swelling of the face, tongue, or throat, and a rapid heartbeat.
5. Infections: Bites and stings can also cause infections, especially if the wound becomes infected or is not properly cleaned and cared for. Symptoms of an infection include redness, swelling, pain, warmth, and pus.

It's important to seek medical attention immediately if you experience any of these symptoms after a bite or sting, as they can be serious and potentially life-threatening. A healthcare professional can assess the severity of the injury and provide appropriate treatment.

The symptoms of acrodermatitis may include:

* Redness and swelling of the skin on the hands and feet
* Blisters or ulcers on the palms and soles
* Itching, burning, or stinging sensations on the affected areas
* Cracking or peeling of the skin on the hands and feet
* Skin thickening and pigmentation on the palms and soles

Acrodermatitis can be diagnosed by a dermatologist based on the appearance of the skin and may require a biopsy to rule out other conditions. Treatment for acrodermatitis typically involves avoiding exposure to allergens or irritants, topical corticosteroids, and in severe cases, systemic medications such as antibiotics or immunosuppressive drugs.

The term "acrodermatitis" is derived from the Greek words "akros," meaning "tip" or "extremity," and "derma," meaning skin. It was first used in the medical literature in the late 19th century to describe a condition characterized by inflammation of the skin on the hands and feet. Since then, the term has been used interchangeably with other terms such as "hand and foot dermatitis" or "acral dermatitis."

In addition to its use in medical literature, the term "acrodermatitis" is also used in some alternative medicine practices to describe a condition characterized by inflammation of the skin on the extremities, typically accompanied by fatigue, fever, and malaise. However, this usage is not widely accepted in conventional medical practice and should be approached with caution.

1. Hantavirus pulmonary syndrome (HPS): This is a severe respiratory disease caused by the hantavirus, which is found in the urine and saliva of infected rodents. Symptoms of HPS can include fever, headache, muscle pain, and difficulty breathing.
2. Leptospirosis: This is a bacterial infection caused by the bacterium Leptospira, which is found in the urine of infected rodents. Symptoms can include fever, headache, muscle pain, and jaundice (yellowing of the skin and eyes).
3. Rat-bite fever: This is a bacterial infection caused by the bacterium Streptobacillus moniliformis, which is found in the saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and swollen lymph nodes.
4. Lymphocytic choriomeningitis (LCM): This is a viral infection caused by the lymphocytic choriomeningitis virus (LCMV), which is found in the urine and saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and meningitis (inflammation of the membranes surrounding the brain and spinal cord).
5. Tularemia: This is a bacterial infection caused by the bacterium Francisella tularensis, which is found in the urine and saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and swollen lymph nodes.

These are just a few examples of the many diseases that can be transmitted to humans through contact with rodents. It is important to take precautions when handling or removing rodents, as they can pose a serious health risk. If you suspect that you have been exposed to a rodent-borne disease, it is important to seek medical attention as soon as possible.

1. Parvovirus (Parvo): A highly contagious viral disease that affects dogs of all ages and breeds, causing symptoms such as vomiting, diarrhea, and severe dehydration.
2. Distemper: A serious viral disease that can affect dogs of all ages and breeds, causing symptoms such as fever, coughing, and seizures.
3. Rabies: A deadly viral disease that affects dogs and other animals, transmitted through the saliva of infected animals, and causing symptoms such as aggression, confusion, and paralysis.
4. Heartworms: A common condition caused by a parasitic worm that infects the heart and lungs of dogs, leading to symptoms such as coughing, fatigue, and difficulty breathing.
5. Ticks and fleas: These external parasites can cause skin irritation, infection, and disease in dogs, including Lyme disease and tick-borne encephalitis.
6. Canine hip dysplasia (CHD): A genetic condition that affects the hip joint of dogs, causing symptoms such as arthritis, pain, and mobility issues.
7. Osteosarcoma: A type of bone cancer that affects dogs, often diagnosed in older dogs and causing symptoms such as lameness, swelling, and pain.
8. Allergies: Dog allergies can cause skin irritation, ear infections, and other health issues, and may be triggered by environmental factors or specific ingredients in their diet.
9. Gastric dilatation-volvulus (GDV): A life-threatening condition that occurs when a dog's stomach twists and fills with gas, causing symptoms such as vomiting, pain, and difficulty breathing.
10. Cruciate ligament injuries: Common in active dogs, these injuries can cause joint instability, pain, and mobility issues.

It is important to monitor your dog's health regularly and seek veterinary care if you notice any changes or abnormalities in their behavior, appetite, or physical condition.

Symptoms of babesiosis can vary in severity and may include:

* Fever
* Chills
* Headache
* Muscle and joint pain
* Fatigue
* Nausea and vomiting
* Diarrhea
* Anemia (low red blood cell count)

In severe cases, babesiosis can lead to complications such as:

* Hemolytic anemia (breakdown of red blood cells)
* Kidney failure
* Respiratory distress syndrome
* Septic shock

Babesiosis is diagnosed through a combination of physical examination, medical history, and laboratory tests, including:

* Blood smear
* Polymerase chain reaction (PCR)
* Enzyme-linked immunosorbent assay (ELISA)

Treatment for babesiosis typically involves the use of antimicrobial drugs, such as azithromycin and atovaquone, or clindamycin and primaquine. In severe cases, hospitalization may be necessary to manage complications.

Prevention of babesiosis primarily involves protecting against tick bites through measures such as:

* Using insect repellents containing DEET or permethrin
* Wearing long-sleeved shirts and pants, and tucking pant legs into socks
* Checking for ticks on the body after spending time outdoors
* Removing any attached ticks promptly and correctly

Early detection and treatment of babesiosis can help to reduce the risk of complications and improve outcomes for affected individuals.

The symptoms of myocarditis can vary depending on the severity of the inflammation and the location of the affected areas of the heart muscle. Common symptoms include chest pain, shortness of breath, fatigue, and swelling in the legs and feet.

Myocarditis can be difficult to diagnose, as its symptoms are similar to those of other conditions such as coronary artery disease or heart failure. Diagnosis is typically made through a combination of physical examination, medical history, and results of diagnostic tests such as electrocardiogram (ECG), echocardiogram, and blood tests.

Treatment of myocarditis depends on the underlying cause and severity of the condition. Mild cases may require only rest and over-the-counter pain medication, while more severe cases may require hospitalization and intravenous medications to manage inflammation and cardiac function. In some cases, surgery may be necessary to repair or replace damaged heart tissue.

Prevention of myocarditis is important, as it can lead to serious complications such as heart failure and arrhythmias if left untreated. Prevention strategies include avoiding exposure to viruses and other infections, managing underlying medical conditions such as diabetes and high blood pressure, and getting regular check-ups with a healthcare provider to monitor cardiac function.

In summary, myocarditis is an inflammatory condition that affects the heart muscle, causing symptoms such as chest pain, shortness of breath, and fatigue. Diagnosis can be challenging, but treatment options range from rest and medication to hospitalization and surgery. Prevention is key to avoiding serious complications and maintaining good cardiac health.

There are several types of erythema, including:

1. Erythema migrans (Lyme disease): A rash that occurs due to an infection with the bacteria Borrelia burgdorferi and is characterized by a red, expanding rash with a central clearing.
2. Erythema multiforme: A condition that causes small, flat or raised red lesions on the skin, often triggered by an allergic reaction to medication or infection.
3. Erythema nodosum: A condition that causes small, painful lumps under the skin, usually due to an allergic reaction to medication or infection.
4. Erythema infectiosum (Fifth disease): A viral infection that causes a red rash on the face, arms, and legs.
5. Erythema annulare centrifugum: A condition that causes a ring-shaped rash with raised borders, often seen in people with autoimmune disorders or taking certain medications.

Treatment for erythema depends on the underlying cause, and may include topical creams or ointments, oral medications, or antibiotics. It is important to seek medical attention if you experience any unusual skin changes or symptoms, as some types of erythema can be a sign of a more serious underlying condition.

Scholia has a topic profile for Borrelia burgdorferi. NCBI Borrelia Taxonomy Browser Borrelia burgdoferi B31 Genome Page (CS1: ... Borrelia burgdorferi is a bacterial species of the spirochete class in the genus Borrelia, and is one of the causative agents ... Borrelia species are Gram-negative. Borrelia burgdorferi is named after the researcher Willy Burgdorfer, who first isolated the ... Borrelia burgdorferi is a microaerophile, requiring small amounts of oxygen in order to undergo glycolysis and survive. Like ...
Most bacterial chromosomes are circular although some examples of linear DNA exist (e.g. Borrelia burgdorferi). Usually a ...
Pathogens that have been shown to recruit factor H include: Aspergillus spp.; Borrelia burgdorferi; B. duttonii; B. recurrentis ... The Gram-negative bacterium B.burgdorferi has five Factor H binding proteins: CRASP-1, CRASP-2, CRASP-3, CRASP-4 and CRASP-5. ...
The major Borrelia species causing Lyme disease are Borrelia burgdorferi, Borrelia afzelii, and Borrelia garinii. All species ... 2020 Borrelia mazzottii ♦ Davis 1956 "Borrelia merionesi" Hougen 1974 "Borrelia microti" (Rafyi 1946) Davis 1948 "Ca. Borrelia ... containing the members of the Lyme disease Borrelia (Borrelia burgdorferi sensu lato complex)". Antonie van Leeuwenhoek. 105 (6 ... Wang G (2015). "Chapter 104 - Borrelia burgdorferi and Other Borrelia Species". Molecular Medical Microbiology. Vol. 3 (Second ...
The Lyme-related Borrelia species are collectively known as Borrelia burgdorferi sensu lato, and show a great deal of genetic ... In North America the bacteria Borrelia burgdorferi and B. mayonii cause Lyme disease. In Europe and Asia Borrelia afzelii, ... and the spirochete was named Borrelia burgdorferi in his honor. After the identification of B. burgdorferi as the causative ... Borrelia afzelii is most frequently detected in rodent-feeding vector ticks, and Borrelia garinii and Borrelia valaisiana ...
Borrelia burgdorferi causes Lyme disease. Rickettsia rickettsii causes Rocky Mountain spotted fever. Rickettsia conorii causes ...
He believed Borrelia burgdorferi was a persistent infection, and that the current serological testing methodologies needed to ... He discovered the bacterial pathogen that causes Lyme disease, a spirochete named Borrelia burgdorferi in his honor. He was ... The agent was named after him - Borrelia burgdorferi. Throughout his career, Burgdorfer participated in a number of World ... Burgdorfer, W. How the discovery of Borrelia burgdorferi came about. Clin. Dermatol. 11:335-338, 1993. Burgdorfer, W. Arthropod ...
OspA from Borrelia burgdorferi is an unusual outer surface protein, it has two globular domains which are connected with a ... Borrelia burgdorferi (responsible for lyme disease) outer surface proteins play a role in persistence within ticks (OspA, OspB ... OspA OspC is a major surface lipoprotein produced by Borrelia burgdorferi when infected ticks feed. OspC is necessary for tick ... "Borrelia burgdorferi OspC Protein Required Exclusively in a Crucial Early Stage of Mammalian Infection". Infection and Immunity ...
Tetracycline is the first choice for treating Borrelia burgdorferi, the causative agent of Lyme disease. Additionally, ... "Antibiotic treatment of experimentally Borrelia burgdorferi-infected ponies". Veterinary Microbiology. 107 (3-4): 285-294. doi: ...
Wormser GP, Schwartz I (July 2009). "Antibiotic treatment of animals infected with Borrelia burgdorferi". Clin. Microbiol. Rev ... a known medical disorder caused by infection with Borrelia burgdorferi, or with post-treatment Lyme disease syndrome, a set of ... A few doctors attribute these symptoms to persistent infection with Borrelia, or co-infections with other tick-borne pathogens ... complexes for which there is no reproducible or convincing scientific evidence of any relationship to Borrelia burgdorferi ...
It is caused by infection with Borrelia burgdorferi. Types include:[citation needed] Acrodermatitis enteropathica ...
In 1997, TIGR determined the genome of Borrelia burgdorferi (which causes Lyme Disease) . In 1998, TIGR sequenced the genome of ... Borrelia burgdorferi". Nature. 390 (6660): 580-586. Bibcode:1997Natur.390..580F. doi:10.1038/37551. PMID 9403685. S2CID 4388492 ...
Infection of ticks happen in the larval/nymph stage (after the first blood meal) when they are exposed to Borrelia burgdorferi ... "Host association of Borrelia burgdorferi sensu lato: A review". Ticks and Tick-borne Diseases. 12 (5): 101766. doi:10.1016/j. ... Although it is a European species from the Lyme borreliosis spirochetes, Borrelia garinii was recently documented from infected ... "Genetic diversity of Borrelia garinii from Ixodes uriae collected in seabird colonies of the northwestern Atlantic Ocean". ...
Other examples are Rickettsia, Buchnera aphidicola, and Borrelia burgdorferi. Small genome size in such species is associated ...
Wolcott KA, Margos G, Fingerle V, Becker NS (June 2021). "Host association of Borrelia burgdorferi sensu lato: A review". Ticks ... NCBI Taxonomy Browser - Borrelia "Borrelia bissettii" at the Encyclopedia of Life Type strain of Borrelia bissettii at BacDive ... "Expanded diversity among Californian borrelia isolates and description of Borrelia bissettii sp. nov. (formerly Borrelia group ... "Whole-genome sequences of Borrelia bissettii, Borrelia valaisiana, and Borrelia spielmanii". Journal of Bacteriology. 194 (2): ...
Ticks, their hosts, and Borrelia burgdorferi on the outer banks of North Carolina. Pp. 7-8 in Apperson, C.S., Levine, J.F. and ... Tick-host associations and maintenance of Borrelia burgdorferi in Virginia. Pp. 8-9 in Apperson, C.S., Levine, J.F. and Snoddy ... Reservoir competence of rice rat and lizards for the Lyme disease spirochete, Borrelia burgdorferi. Pp. 11-13 in Apperson, C.S ... Levine, Jay F.; Sonenshine, Daniel E.; Nicholson, William L.; Turner, R. T. (1991). "Borrelia burgdorferi in Ticks (Acari: ...
Antibodies against Borrelia burgdorferi, the bacterium that causes Lyme disease in the United States, have been found in marsh ... IgG antibodies to Borrelia burgdorferi in rodents in Tennessee. Journal of Spirochetal and Tick-Borne Diseases 3(3-4):130-134. ... Ticks and antibodies to Borrelia burgdorferi from mammals at Cape Hatteras, NC and Assateague Island, MD and VA (abstract only ...
In most places in the US, 30-50% of deer ticks will be infected with Borrelia burgdorferi (the agent of Lyme disease). Other ... Wolcott KA, Margos G, Fingerle V, Becker NS (September 2021). "Host association of Borrelia burgdorferi sensu lato: A review". ... Major tick-borne diseases include: Lyme disease or borreliosis Organism: Borrelia burgdorferi sensu lato (bacterium) Vector: at ... different from Lyme disease due to different Borrelia species and ticks) Organisms: Borrelia species such as B. hermsii, B. ...
... as well as the Escherichia coli and Borrelia burgdorferi N,N'-diacetylchitobiose (Chb) porters. It is part of the PTS-GFL ... "Genetics and regulation of chitobiose utilization in Borrelia burgdorferi". Journal of Bacteriology. 183 (19): 5544-5553. doi: ... While the Lac porters consist of two polypeptide chains (IIA and IICB), the Chb porters of E. coli and B. burgdorferi consist ...
"Borrelia burgdorferi in Ticks (Acari: Ixodidae) from Coastal Virginia". Journal of Medical Entomology. 28 (5): 668-674. doi: ...
In addition, cat fleas have been found to carry Borrelia burgdorferi, the etiologic agent of Lyme disease, but their ability to ... Teltow GJ, Fournier PV, Rawlings JA (May 1991). "Isolation of Borrelia burgdorferi from arthropods collected in Texas". Am J ...
The bacterium that causes Lyme is Borrelia burgdorferi, a spirochete. A number of other bacteria are transmitted by ticks, such ... Faulde MK, Robbins RG (February 2008). "Tick infestation risk and Borrelia burgdorferi s.l. infection-induced increase in host- ... There is some evidence that Ixodes ricinus infected with Borrelia burgdorferi may become more efficient at infestation. ...
McInerney JO (1998). "Replicational and transcriptional selection on codon usage in Borrelia burgdorferi". Proc Natl Acad Sci ...
1997). "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi". Nature. 390 (6660): 580-586. Bibcode:1997Natur. ...
PPachner, A. R. (1988). "Borrelia burgdorferi in the nervous system: The new "great imitator"". Annals of the New York Academy ... he was noted to have positive serologic tests for Borrelia burgdorferi. Treatment with a 14 day course of intravenous ...
Transtadial (between tick stages) passage of Borrelia burgdorferi is common. Vertical passage (from mother to egg) of Borrelia ... It can also transmit other Borrelia species, including Borrelia miyamotoi. Ticks that transmit B. burgdorferi to humans can ... While adult deer ticks are more likely to carry and transmit Borrelia burgdorferi, it is more common for the hard-to-spot ... "Role of migratory birds in introduction and range expansion of Ixodes scapularis ticks and of Borrelia burgdorferi and ...
1997). "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi". Nature. 390 (6660): 580-6. Bibcode:1997Natur.390 ... 2004). "Comparative analysis of the Borrelia garinii genome". Nucleic Acids Res. 32 (20): 6038-46. doi:10.1093/nar/gkh953. PMC ...
McInerney, J. O. (1 September 1998). "Replicational and transcriptional selection on codon usage in Borrelia burgdorferi". ... career focused on the study of codon usage in a variety of organisms including Trichomonas vaginalis and Borrelia burgdorferi. ...
McInerney, James O. (1998-09-01). "Replicational and transcriptional selection on codon usage in Borrelia burgdorferi". ...
Pachner AR (1988). "Borrelia burgdorferi in the nervous system: the new "great imitator"". Annals of the New York Academy of ...
Examples of this are seen in Streptococcus pyogenes and Borrelia burgdorferi. It is possible, but uncommon for molecular ...
Several studies have failed to detect Borrelia burgdorferi, which is the causative agent of Lyme disease, in patients from the ... Borrelia Zoonosis Kirkland KB, Klimko TB, Meriwether RA, et al. (1997). "Erythema migrans-like rash illness at a camp in North ... It is spread by tick bites and it was hypothesized that the illness was caused by the bacteria Borrelia lonestari. However, ... This disease may be caused by the related bacterium Borrelia lonestari, which is a spirochete first isolated in culture in 2004 ...
Host associations of ticks parasitizing rodents at Borrelia burgdorferi enzootic sites in South Carolina. Journal of ...
Genetic remains of the bacterium that causes Lyme disease, Borrelia burgdorferi, were discovered in the body. Not only can past ...
Lantos, P. M.; Auwaerter, P. G.; Wormser, G. P. (12 December 2013). "A Systematic Review of Borrelia burgdorferi Morphologic ... This culture method was discredited when it was found that the method used a medium that killed B. burgdorferi. Mattman also ... Mattman developed a new method for culturing B. burgdorferi from patients with purported chronic Lyme disease. ... "A proposal for the reliable culture ofBorrelia burgdorferi from patients with chronic lyme disease, even from those previously ...
Borrelia burgdorferi, a bacterium that causes lyme disease, can affect multiple large joints such as the knee. Confirmation of ... immunocompromised state Borrelia burgdorferi - ticks, causes lyme disease Spirillum minus, Streptobacillus moniliformis - rat ... Synovial fluid PCR analysis is useful in finding less common organisms such as Borrelia species. However, measuring protein and ...
... which include Lyme disease bacterial variants Borrelia burgdorferi and Rickettsia rickettsii. A number of scientists who have ...
Lyme disease, an infection caused by Borrelia burgdorferi bacteria and spread by ticks, can account for about 25% of cases of ...
Holden K, Boothby JT, Anand S, Massung RF (July 2003). "Detection of Borrelia burgdorferi, Ehrlichia chaffeensis, and Anaplasma ...
"Use of nonelectrolytes reveals the channel size and oligomeric constitution of the Borrelia burgdorferi P66 porin". PLOS ONE. 8 ...
Mitchell, PD; Reed, KD; Hofkes, JM (1996). "Immunoserologic evidence of coinfection with Borrelia burgdorferi, Babesia microti ...
... receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells". FASEB J. 6 ...
A recent study in British Columbia of 218 deer mice showed 30% (66) were seropositive for Borrelia burgdorferi, the agent of ...
Introduction of the Borrelia burgdorferi blyAB locus into Escherichia coli produces a hemolytic phenotype that is dependent on ... Damman, C. J.; Eggers, C. H.; Samuels, D. S.; Oliver, D. B. (2000-12-01). "Characterization of Borrelia burgdorferi BlyA and ... from Borrelia burgdorferi". International Journal of Medical Microbiology. 298 (5-6): 473-481. doi:10.1016/j.ijmm.2007.07.014. ... BlyA membrane protein and the BlyB soluble accessory protein are encoded on the conserved cp32 plasmid of Borrelia burgdorferi ...
"Northern White-Breasted Hedgehogs Erinaceus Roumanicus as Hosts for Ticks Infected with Borrelia Burgdorferi Sensu Lato and ...
Hansen, K; Cruz, M; Link, H (June 1990). "Oligoclonal Borrelia burgdorferi-specific IgG antibodies in cerebrospinal fluid in ...
... psittaci Borrelia burgdorferi the causative agent of Lyme disease (borreliosis) magnified 400 times TEM micrograph showing ...
for his research on Effects of Low Frequency Magnetic Fields on Borrelia burgdorferi. List of German scientists Manfred E Bayer ...
... in the natural cycle of Borrelia burgdorferi sensu lato, the Lyme disease spirochaete". International Journal of Medical ... Borrelia bacteria. Some species of Borrelia cause Lyme disease, and ground-feeding birds like the song thrush may act as a ...
A mutant strain of rrp1 has been found to cause growth deficits with Borrelia burgdorferi. In Escherichia coli, the chb operon ... Chitobiose is utilized by Borrelia burgdorferi to produce N-acetylglucosamine, a component of the bacterial cell wall, and is ... of the response regulator Rrp1 reveals its regulatory role in chitobiose utilization and virulence of Borrelia burgdorferi". ...
... has recently been found to have excellent activity against stationary phase Borrelia burgdorferi, the causative ... "Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound ...
Lyme disease, caused by the spirochete Borrelia burgdorferi, is a tick-borne illness with both peripheral and central ...
Initially thought to be associated with Borrelia burgdorferi this organism was finally brought to light with more advanced ...
Lyme disease is an infection of the Borrelia burgdorferi bacterium that is spread through black legged ticks (otherwise known ... corkscrew shaped bacteria called spirochetes and with the name Borrelia burgdorferi. When the bacteria invade our bodies and ...
... Christina ... Assessment of new culture method for detection of Borrelia species from serum of Lyme disease patients. J Clin Microbiol 2014; ... has received inquiries regarding a laboratory-developed test that uses a novel culture method to identify Borrelia burgdorferi ... Improved culture conditions for the growth and detection of Borrelia from human serum. Int J Med Sci 2013;10:362-76. ...
Lyme disease is caused by a bacterium called Borrelia burgdorferi. It is known as a spirochete because of its long, corkscrew ... Lyme disease is caused by a bacterium called Borrelia burgdorferi. It is known as a spirochete because of its long, corkscrew ...
Isolation of the B. burgdorferi from different organs six months post infection causes a generalized infection thus ... Gerbils appear to be susceptible to infection by human isolates of Borrelia burgdorferi; we obtained 100% infection. ... The Borrelia burgdorferi specific antibody titers increased with time after infection thus indicating the persistence of ... Persistence of Borrelia burgdorferi and histopathological alterations in experimentally infected animals. A comparison with ...
Atovaquone plus cholestyramine in patients coinfected with Babesia microti and Borrelia burgdorferi refractory to other ... A double-blind, placebo-controlled, crossover trial enrolled 25 patients with confirmed Borrelia burgdorferi/B microti ... Atovaquone plus cholestyramine in patients coinfected with Babesia microti and Borrelia burgdorferi refractory to other ... Patients coinfected with B burgdorferi and B microti derive measurable clinical benefit from prolonged treatment with ...
Basis für diese Untersuchungen war das bakterielle Lipoprotein OspA (outer surface protein A) aus Borrelia burgdorferi. Dieses ... Previous studies have been shown that OspA is lipidated on its N-terminus both in B. burgdorferi and when expressed in ... burgdorferi als auch nach heterologer Expression in E. coli einer post-translationalen Lipidierung am N-Terminus unterliegt. ... For this investigation, the bacterial lipoprotein OspA (outer surface protein A) of Borrelia burgdorferi was chosen, a protein ...
Tag Archives: Borrelia burgdorferi. Lyme Disease is more tenacious than a Master Earthdog. Posted on June 22, 2012. by Toni ... Posted in Health & Wellness, Terrier Community, Terrier Logic, Uncategorized , Tagged Borrelia burgdorferi, Dogs, Earthdog, ... Recent reports say that 10% of black-legged ticks carry the bacteria (Borrelia burgdorferi) that`s responsible for Lyme Disease ... Posts about Borrelia burgdorferi written by Toni ...
Borrelia burgdorferi Antibody [1D5] is a Mouse monoclonal antibody. It reacts with Bacteria/Archaea. This antibody has been ... B burgdorferi antibody;B. burgdorferi antibody;B.burgdorferi antibody;Lyme disease antibody. ... Mouse Anti-Borrelia burgdorferi[1D5]. Target Antigen:. Recognizes a flagellar antigen on the surface of Borrelia burgdorferi. ...
Be the first to review "S BORRELIA burgdorferi IgM WB" Cancel reply. Your email address will not be published. Required fields ... S BORRELIA burgdorferi IgM WB. RSD4,000.00. S BORRELIA burgdorferi IgM WB quantity. ...
Borrelia burgdorferi) case definitions; uniform criteria used to define a disease for public health surveillance. ... Lyme Disease (Borrelia burgdorferi) , 2022 Case Definition. *Lyme Disease (Borrelia burgdorferi) , 2017 Case Definition ... Lyme Disease (Borrelia burgdorferi) , 2011 Case Definition. *Lyme Disease (Borrelia burgdorferi) , 2008 Case Definition ... Lyme Disease (Borrelia burgdorferi) , 1996 Case Definition. *Lyme Disease (Borrelia burgdorferi) , 1995 Case Definition ...
Rabbit Anti-Borrelia burgdorferi CRASP-2 antibody is a polyclonal recognising Borrelia burgdorferi, for use in ELISA and ... Rabbit Anti-Borrelia burgdorferi CRASP-2 antibody is a polyclonal recognising Borrelia burgdorferi sensu stricto. The antibody ... PRODUCT DETAILS - RABBIT ANTI-BORRELIA BURGDORFERI SENSU STRICTO (B31) CRASP-2 ANTIBODY. *Rabbit anti-B. burgdorferi sensu ... Home / Products / All Products / Veterinary / Borrelia antibodies / Rabbit Anti-Borrelia burgdorferi sensu stricto (B31) CRASP- ...
Borrelia Burgdorferi (Lyme disease) Antibody Level. CPT Code 86618 A blood test that determines if lyme disease bacteria is ... antibodies for borrelia burgdorferi).. Show Related Procedures Related Procedures. Related procedures are health care services ...
Seroprevalence of West Nile virus, Crimean-Congo hemorrhagic fever virus, Francisella tularensis and Borrelia burgdorferi in ... Francisella tularensis and Borrelia burgdorferi among the rural residents of Manisa region, Turkey and to identify the ... burgdorferi with commercially available kits. The demographic structure of the rural residents and risk factors related to ... burgdorferi were 4.3% (n = 14), 3.7% (n = 12) and 0.9% (n = 3), respectively. Older age and uncompleted secondary education ...
Increased prevalence of Borrelia burgdorferi infections in Bernese Mountain Dogs: a possible breed predisposition. Overview of ... Increased prevalence of Borrelia burgdorferi infections in Bernese Mountain Dogs: a possible breed predisposition ... burgdorferi. The aim of this study was to determine the prevalence of antibodies against B. burgdorferi sensu lato in a well ... In Bernese Mountain Dogs with glomerulonephritis antibodies against B. burgdorferi have been found in most dogs, raising the ...
BBA03 is a Borrelia burgdorferi outer surface lipoprotein encoded on one of the most conserved plasmids in Borrelia genome, ... N2 - BBA03 is a Borrelia burgdorferi outer surface lipoprotein encoded on one of the most conserved plasmids in Borrelia genome ... AB - BBA03 is a Borrelia burgdorferi outer surface lipoprotein encoded on one of the most conserved plasmids in Borrelia genome ... abstract = "BBA03 is a Borrelia burgdorferi outer surface lipoprotein encoded on one of the most conserved plasmids in Borrelia ...
Lyme disease is a multisystem illness caused by infection with the spirochete Borrelia burgdorferi and the bodys immune ... Borrelia burgdorferi infectious cycle. The infectious cycle of B burgdorferi involves colonization, infection of Ixodes ticks, ... The spirochete Borrelia burgdorferi is introduced into the skin with a bite from an infected Ixodes tick. In the northeastern ... Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritis. Proc Natl Acad Sci U S A. 2019 Jul ...
Lyme encephalopathy: Arising from Lyme disease bacteria, including Borrelia burgdorferi.. *Toxic encephalopathy: A form of ...
Dive into the research topics of The flat-ribbon configuration of the periplasmic flagella of Borrelia burgdorferi and its ... T1 - The flat-ribbon configuration of the periplasmic flagella of Borrelia burgdorferi and its relationship to motility and ... title = "The flat-ribbon configuration of the periplasmic flagella of Borrelia burgdorferi and its relationship to motility and ... The flat-ribbon configuration of the periplasmic flagella of Borrelia burgdorferi and its relationship to motility and ...
Borrelia burgdorferi. Tooth Decay. Streptococcus mutans. Tooth Decay. Streptococcus sobrinus. Tooth Decay. Streptococcus ... In later stages, this plaque can also involve species of Fusobacterium, Borrelia and Actinomycetes. ...
Borrelia burgdorferi The following in vitro data are available, but their clinical significance is unknown. At least 90 percent ... of the presence of antibodies specific to Borrelia burgdorferi, the etiologic agent of Lyme disease. The efficacy data in Table ... caused by susceptible strains of Borrelia burgdorferi. ...
Borrelia burgdorferi (causes Lyme disease). *Corynebacterium diphtheriae (diphtheria). *Legionella pneumophila (Legionnaires ...
Also, the low infection levels of Borrelia and C. burnetii and lack of Babesia among the febrile patients call for further ... was present among 57 (60.2%) of the 88 malaria RDT-negative patients, whereas the prevalence of Borrelia, C. burnetii, and ... were used to assess the presence of sub-RDT Plasmodium falciparum as well as Borrelia, Coxiella burnetii, and Babesia applying ... Biology of infection with Borrelia burgdorferi. Infect Dis Clin North Am 22: 217-234. ...
Destruction of spirochete Borrelia burgdorferi round-body propagules (RBs) by the antibiotic tigecycline. Proc. Natl Acad. Sci ...
Fatty acids of Treponema pallidum and Borrelia burgdorferi lipoproteins. J Bacteriol. 1994;176:2151-2157. ...
... is an infection caused by the Borrelia burgdorferi bacteria. Deer ticks and Western blacklegged ticks can bite ...
... from Borrelia burgdorferi-infected ticks that escaped from a laboratory at the Plum Island Animal Disease Center where ... Borrelia burgdorferi, is transmitted only by Ixodes ticks, the question of sexual transmission of Borrelia burgdorferi has been ... At one time, Borrelia burgdorferi, was thought to possess an endotoxin since a product isolated from B. burgdorferi was ... OspA and OspB, though certainly specific for Borrelia burgdorferi, are expressed primarily when B. burgdorferi is grown on ...
  • Borrelia burgdorferi is a bacterial species of the spirochete class in the genus Borrelia , and is one of the causative agents of Lyme disease in humans. (wikipedia.org)
  • [1] [2] Along with a few similar genospecies, some of which also cause Lyme disease, it makes up the species complex of Borrelia burgdorferi sensu lato . (wikipedia.org)
  • [2] B. burgdorferi sensu stricto exists in North America and Eurasia and until 2016 was the only known cause of Lyme disease in North America. (wikipedia.org)
  • However, the prevalence of Borrelia burgdorferi , Northeast (82%), followed distantly by the Midwest (9%) the bacterium that causes Lyme disease, in the tick vector ( 1 ). (cdc.gov)
  • We address the Lyme disease incidence may result from a disparity in the hypothesis that B. burgdorferi populations in the Northeast human invasiveness of the bacteria in the Northeast and Midwest caused by fundamentally different evolutionary and Midwest have fundamentally different evolutionary histories. (cdc.gov)
  • Lyme disease, caused by the bacterium Borrelia burg- Genetic loci are found in perfect or near-perfect association dorferi , is the most common vector-borne disease in the in B. burgdorferi in the Northeast ( 9-12 ). (cdc.gov)
  • Evidence is strong human Lyme disease cases reported in the Northeast and that recombination occurs within a genomic lineage of B. burgdorferi ( 15-17 ). (cdc.gov)
  • Recently, CDC has received inquiries regarding a laboratory-developed test that uses a novel culture method to identify Borrelia burgdorferi , the spirochete that causes Lyme disease. (cdc.gov)
  • Assessment of new culture method for detection of Borrelia species from serum of Lyme disease patients. (cdc.gov)
  • Lyme disease is caused by a bacterium called Borrelia burgdorferi . (medlineplus.gov)
  • The persistence of B. burgdorferi and the high number of organs involved with slight to severe signs of inflammation in this series can be compared to persistence and to the multiorgan involvement seen in human Lyme disease. (nih.gov)
  • Thus gerbils can serve as suitable experimental animals to study the pathogenesis of Lyme disease and the extent of organ damage caused by B. burgdorferi. (nih.gov)
  • An NIH-supported team recently uncovered a unique gene expression pattern in white blood cells from people infected with the Lyme disease-causing bacterium Borrelia burgdorferi [1]. (nih.gov)
  • Recent reports say that 10% of black-legged ticks carry the bacteria (Borrelia burgdorferi) that`s responsible for Lyme Disease. (terrierlogic.com)
  • A blood test that determines if lyme disease bacteria is present (antibodies for borrelia burgdorferi). (nh.gov)
  • B. burgdorferi -infected ticks can cause Lyme disease in mammalian hosts. (nih.gov)
  • This technology relates to the use of B. burgdorferi outer surface proteins (BBA64 and BBA66) as Lyme disease vaccine candidates. (nih.gov)
  • Lyme disease, the most common vector-borne illness in the United States, is a multisystem illness usually caused by infection with the spirochete Borrelia burgdorferi (see the image below) and the body's immune response to the infection. (medscape.com)
  • Lyme disease is an infection caused by Borrelia Burgdorferi, a spirochete bacterium carried by deer ticks and transmitted to humans through a bite. (seattledailyobserver.com)
  • Electron cryotomography was used to analyze the structure of the Lyme disease spirochete, Borrelia burgdorferi. (arizona.edu)
  • This initiative also targets development of more sensitive and accurate methods of detection of Borrelia burgdorferi, leading to improved diagnostics for Lyme disease. (nih.gov)
  • Another example is Borrelia burgdorferi , which can cause Lyme disease. (nih.gov)
  • The most common tick-borne illness in the United States, Lyme disease is caused by Borrelia burgdorferi bacteria that are transmitted to people by Ixodes scapularis ticks. (nih.gov)
  • To see if ticks can be used to detect B. burgdorferi in people who have had Lyme disease and received antibiotic therapy and if it correlates with persistent symptoms. (nih.gov)
  • Lyme disease is a common vector-borne illness most often caused by Borrelia burgdorferi in infected ticks. (medscape.com)
  • [ 1 ] Lyme disease is typically caused by Borrelia burgdorferi and rarely by Borrelia mayonii . (medscape.com)
  • B. burgdorferi is a microaerobic , motile spirochete with seven to 11 bundled perisplasmic flagella set at each end that allow the bacterium to move in low- and high-viscosity media alike, which is related to its high virulence factor. (wikipedia.org)
  • B. burgdorferi is a slow-growing microaerophilic spirochete with a doubling time of 24 to 48 hours. (wikipedia.org)
  • This is a polyclonal antibody, prepared against CRASP-2 from the spirochete B. burgdorferi, for use in ELISA and western blotting applications. (thenativeantigencompany.com)
  • What concerns us is not what this creature takes but rather what it leaves in our body after it bites us: corkscrew shaped bacteria called spirochetes and with the name Borrelia burgdorferi. (scienceblogs.com)
  • Here, we evaluated the activity of 34 essential oils against B. burgdorferi stationary phase culture as a model for persister bacteria. (frontiersin.org)
  • These proteins represent another immune evasion mechanism of B. burgdorferi , as bacteria acquire human complement regulators to control complement activation on their surface and prevent formation of toxic activation products (Kraiczy, et al. (thenativeantigencompany.com)
  • Deer are vitally important to the survival of deer ticks, but they are not involved with transmitting the Lyme bacteria, Borrelia burgdorferi ," explains senior author Stephen Rich, professor of microbiology. (outbreaknewstoday.com)
  • In this paper, we report the solution NMR structure of the B. burgdorferi outer surface lipoprotein BBA03, which is known to provide a competitive advantage to the bacteria during the transmission from tick vector to mammalian host. (rsu.lv)
  • B. burgdorferi circulates between Ixodes ticks and a vertebrate host in an enzootic cycle . (wikipedia.org)
  • The illness is transmitted by a tick bite and in some endemic areas, where more than 40% of the ticks are infected with the causative agent of Borreliosis, Borrelia burgdorferi sensu lato complex species, which increases the risk of transmission to human host ( 2 ). (frontiersin.org)
  • Blood samples from 324 randomly selected subjects were screened for the presence of IgG antibodies to WNV, CCHFV, F. tularensis and B. burgdorferi with commercially available kits. (bvsalud.org)
  • In Bernese Mountain Dogs with glomerulonephritis antibodies against B. burgdorferi have been found in most dogs, raising the question if the breed is predisposed to infections with B. burgdorferi. (altmetric.com)
  • The aim of this study was to determine the prevalence of antibodies against B. burgdorferi sensu lato in a well defined population of Bernese Mountain Dogs and to compare this prevalence with data from dogs of other breeds. (altmetric.com)
  • Projects will focus on approaches that provide substantial and significant advances over conventional serology-based diagnostics using antibodies, consider host responses, and/or have the capacity to detect and differentiate multiple B. burgdorferi strains. (nih.gov)
  • B. burgdorferi strains appear to be highly insufficient for use in bacterial transformation due to the large amount of DNA needed for transformation, the time it takes to produce reliable transformants, and the influence of restriction modification systems . (wikipedia.org)
  • 1984). CRASP-2 (CSPz) is a 20/21-kDa protein which binds to FHL-1 and factor H binding protein (although it interacts preferentially with Factor H) and may be predominantly expressed by serum-resistant Borrelia strains (Rossmann, et al. (thenativeantigencompany.com)
  • If the patient has been in Europe, where different strains of Borrelia are more common, a C6 peptide ELISA is a more accurate confirmatory test than the Western blots, which have been developed to B burgdorferi , which is the most common strain found in the United States. (medscape.com)
  • [19] Despite this, some headway has been made in unraveling the mysteries of B. burgdorferi, such as the discovery of gene cyaB as essential for mammalian infection. (wikipedia.org)
  • Isolation of the B. burgdorferi from different organs six months post infection causes a generalized infection thus demonstrating that borreliae persist in these animals for a long period. (nih.gov)
  • The Borrelia burgdorferi specific antibody titers increased with time after infection thus indicating the persistence of spirochetes. (nih.gov)
  • Rabbit Anti- Borrelia burgdorferi CRASP-2 antibody is a polyclonal recognising Borrelia burgdorferi sensu stricto. (thenativeantigencompany.com)
  • In the United States, this is usually a bacterium called Borrelia burgdorferi. (nih.gov)
  • The activity of all agents against 16 different Borrelia isolates belonging to all borrelial genospecies known to be pathogenic for humans was investigated and analyzed under standardized conditions. (nih.gov)
  • B. burgdorferi is transmitted to humans disequilibrium among genetic loci can result from several during the blood meal of an infected Ixodes tick, predomi- evolutionary and ecologic forces in addition to small popu- nantly Ixodes scapularis in North America ( 2 ). (cdc.gov)
  • B. burgdorferi resembles other spirochetes in that it has an outer membrane and inner membrane with a thin layer of peptidoglycan in between. (wikipedia.org)
  • The program eliminates not only the Borrelia organism but also the equally troublesome co-infections from other organisms. (seattledailyobserver.com)
  • In later stages, this plaque can also involve species of Fusobacterium, Borrelia and Actinomycetes. (earthlife.net)
  • Seroprevalence of West Nile virus, Crimean-Congo hemorrhagic fever virus, Francisella tularensis and Borrelia burgdorferi in rural population of Manisa, western Turkey. (bvsalud.org)
  • The aim of this study was to determine the seroprevalence of West Nile virus (WNV), Crimean-Congo hemorrhagic fever virus (CCHFV), Francisella tularensis and Borrelia burgdorferi among the rural residents of Manisa region, Turkey and to identify the associated risk factors . (bvsalud.org)
  • However, the activity of essential oils against the causative agent Borrelia burgdorferi ( B. burgdorferi ) has not been well studied. (frontiersin.org)
  • [7] B. burgdorferi possesses flagella that allow it motility. (wikipedia.org)
  • Previous results indicate that B. burgdorferi motility is dependent on the rotation of the periplasmic flagella in generating backward-moving waves along the length of the cell. (arizona.edu)
  • Basis für diese Untersuchungen war das bakterielle Lipoprotein OspA (outer surface protein A) aus Borrelia burgdorferi. (uni-wuerzburg.de)
  • In vivo animal studies demonstrate these outer surface proteins inhibit tick-to-host B. burgdorferi transmission. (nih.gov)
  • BBA03 is a Borrelia burgdorferi outer surface lipoprotein encoded on one of the most conserved plasmids in Borrelia genome, linear plasmid 54 (lp54). (rsu.lv)
  • Genomic coordinate predictions for the boundaries of ORFs, 5′ UTRs, 3′ UTRs, rRNAs, tRNAs, and sRNAs for B. burgdorferi grown to logarithmic phase in BSKII culture media, at 35°C. (nih.gov)
  • Dieses Protein wird zur Prävention von Lyme-Borreliose eingesetzt und frühere Untersuchungen zeigten, dass OspA sowohl in B. burgdorferi als auch nach heterologer Expression in E. coli einer post-translationalen Lipidierung am N-Terminus unterliegt. (uni-wuerzburg.de)
  • 2005. A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi. (thenativeantigencompany.com)
  • Complement regulator-acquiring surface protein 1 of Borrelia burgdorferi binds to human bone morphogenic protein 2, several extracellular matrix proteins, and plasminogen. (thenativeantigencompany.com)
  • 2004. Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins. (thenativeantigencompany.com)
  • Improved culture conditions for the growth and detection of Borrelia from human serum. (cdc.gov)
  • Glomerulonephritis in dogs has been associated with B. burgdorferi infections. (altmetric.com)
  • It may be oxidase negative, but B. burgdorferi possesses a gene coding for superoxide dismutase . (wikipedia.org)
  • [17] [18] In fact, infectivity of B. burgdorferi often requires the gene pncA , which is present on a bacterial plasmid that contains the gene bbe02 that is highly selected against during transformation. (wikipedia.org)
  • The preva- lation size (drift), such as lack of recombination machinery lence and density of B. burgdorferi -infected I. scapularis or limited opportunity for gene exchange ( 13 ). (cdc.gov)
  • Bacterial transformation has been utilized by researchers in order to isolate specific pathogenic genes among the Borrelia burgdorferi . (wikipedia.org)
  • B. burgdorferi differ in their susceptibility to normal human serum and are therefore classified as complement-resistant, complement-sensitive and intermediate complement-sensitive. (thenativeantigencompany.com)
  • [2] B. burgdorferi living in a tick is mainly acquired through blood meals from an infected, competent vertebrate host, [21] but rare cases of transovarial transmission exist. (wikipedia.org)
  • Patients coinfected with B burgdorferi and B microti derive measurable clinical benefit from prolonged treatment with atovaquone and cholestyramine. (druglib.com)
  • Atovaquone plus cholestyramine in patients coinfected with Babesia microti and Borrelia burgdorferi refractory to other treatment. (druglib.com)
  • A double-blind, placebo-controlled, crossover trial enrolled 25 patients with confirmed Borrelia burgdorferi/B microti coinfection, abnormal visual contrast sensitivity (VCS), and persistent symptoms despite prior treatment with atovaquone and azithromycin. (druglib.com)
  • We found that not all essential oils had activity against the B. burgdorferi stationary phase culture, with top five essential oils (oregano, cinnamon bark, clove bud, citronella, and wintergreen) at a low concentration of 0.25% showing high anti-persister activity that is more active than the known persister drug daptomycin. (frontiersin.org)
  • Carvacrol was found to be the most active ingredient of oregano oil showing excellent activity against B. burgdorferi stationary phase cells, while other ingredients of oregano oil p-cymene and α-terpinene had no apparent activity. (frontiersin.org)
  • We found that the periplasmic space of B. burgdorferi was quite narrow (16.0 nm) compared to those of Escherichia coli and Pseudomonas aeruginosa. (arizona.edu)
  • Borrelia burgdorferi is a microaerophile, requiring small amounts of oxygen in order to undergo glycolysis and survive. (wikipedia.org)
  • linkage disequilibrium within B. burgdorferi populations likely result from small effective population sizes ( 9-11 ). (cdc.gov)
  • 16 mg/L). High in vitro activity of the new glycylcycline against Borrelia was further substantiated by time-kill experiments performed with B. afzelii isolate EB1. (nih.gov)
  • Distribution of the positive results for WNV, CCHFV and B. burgdorferi were 4.3% (n = 14), 3.7% (n = 12) and 0.9% (n = 3), respectively. (bvsalud.org)