Borna disease virus
A species in the genus Bornavirus, family BORNAVIRIDAE, causing a rare and usually fatal encephalitic disease in horses and other domestic animals and possibly deer. Its name derives from the city in Saxony where the condition was first described in 1894, but the disease occurs in Europe, N. Africa, and the Near East.
Newcastle disease virus
Foot-and-Mouth Disease Virus
Mononegavirales
Infectious bursal disease virus
Bornaviridae
Virus Replication
Aphthovirus
Parapoxvirus
Vero Cells
Horses
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Cercopithecus aethiops
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Viral Structural Proteins
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
Newcastle Disease
Hemorrhagic Disease Virus, Rabbit
Gene Expression Regulation, Viral
Marek Disease
Base Sequence
Electrophoresis, Gel, Two-Dimensional
Neuroglia
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Cell Adhesion Molecules, Neuronal
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
Neurons
Retina
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
Transcription, Genetic
Lung
Interferons
Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.
Rabbits
Interferon Type I
Central Nervous System Infections
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
Taste
Reverse transcription-nested polymerase chain reaction for detecting p40 RNA of Borna disease virus, without risk of plasmid contamination. (1/250)
Several methods for the detection of Borna disease virus (BDV) RNA have been reported, one being the reverse transcription-nested polymerase chain reaction (RT-nested PCR) method. However, due to the possibility of contamination of the cloned DNA in a reaction tube, false-positive results might be obtained by RT-nested PCR. To detect only BDV RNA without anxiety of contamination, we developed an RT-nested PCR system using "mRNA selective PCR kit". Using this system, cDNA of BDV p40 in the plasmid (up to 5 x 10(7) molecules) was not amplified. BDV specific sequence was amplified from total RNA (more than 50 pg) of MDCK/BDV cells, which were persistently infected with BDV. These results indicate that this mRNA selective RT-nested PCR system can specifically amplify target RNA as distinguished from plasmid contaminated. (+info)A serosurvey of Borna disease virus infection in wild rats by a capture ELISA. (2/250)
For a serological diagnostic test for Borna disease (BD), we developed a capture ELISA with specificity and sensitivity based on detection of antibodies against BD virus (BDV) p40 protein. Using our capture ELISA system, the antibody response of rats inoculated intracerebrally with BDV at 4 weeks after birth showed a sharp increase from 1 to 4 weeks postinoculation (p.i.) and a steady level after 5 weeks p.i. To investigate prevalence of BDV infection among wild rats, we examined sera of Rattus norvegicus in Kami-iso town, Oshima district, Hokkaido, suggesting that rats in this area had not been infected by BDV. (+info)Immortalized cell lines derived from mice lacking both type I and type II IFN receptors unify some functions of immature and mature dendritic cells. (3/250)
Cells with dendritic morphology obtained from several organs of mice lacking both type I and II IFN receptors were immortalized by a retrovirus and analysed for their phenotype and for their function to induce cognate immune responses in vitro and in vivo. Two cell lines called AG101 (skin) and AG116 (brain) were cloned and analysed in more detail. They constitutively expressed the cell surface markers CD45, CD11b, MHC class II, F4/80, N418, B7-2 and ICAM1 but were CD8- and B220-negative. Cells from both lines were capable of taking up ovalbumin (OVA). The processed protein was presented to the OVA-specific T cell hybridoma BO97.105 which responded specifically with the production of IL-2. AG101 and AG116 cells were able to induce a mixed lymphocyte reaction as shown by a 50-fold increase of IL-2 production over background. Naive T cells were stimulated by antigen-primed AG101 and AG116, resulting in a T cell proliferation which was 20-30 times over background, and in IL-2 production it was 10 times the background. The capacity of AG101 or AG116 cells to prime naive T cells was directly compared with freshly isolated and cultured cutaneous dendritic cells (DC) from 129 Sv/Ev mice (wtDC). After cognate T cell interaction, IL-6 (20-100-fold) and IL-12 p40 (100-1000-fold) were similarly up-regulated in either AG101, AG116 or mature wtDC. To analyse the capacity of the immortalized DC to induce antibodies in vivo, cell line AG116 was permanently infected with Borna disease virus (BDV) which is unable to replicate in adult mice. One hundred and twenty-nine Sv/Ev mice injected with different cell numbers of AG116 carrying BDV (but not control cells) produced antibodies against the viral BDVp40 and BDVp24 protein. Therefore, the cell lines AG101 and AG116 appear to unify some functions of immature and mature DC. They are able to pick up antigen and process it. In the absence of externally added cytokines, the antigen presented on AG101 or AG116 cells drives T cells with an efficiency similar to mature DC. The cloned cell lines may prove to be useful to study both immune response and replication of infectious agents in the absence of functional interferon receptors. (+info)Nuclear localization of the protein from the open reading frame x1 of the Borna disease virus was through interactions with the viral nucleoprotein. (4/250)
Previous studies have predicted the presence of a small open reading frame (ORFx1) located between ORF-1 and ORF-2 of the Borna disease viral (BDV) genome. The ORFx1 is expressed as a p10 protein that is localized in the nucleus and cytoplasm of BDV-infected cells. In this study, we cloned the nucleotide sequence of ORFx1 into expression vectors and showed that it is expressed as p10. An anti-p10 serum gave nuclear and cytoplasmic staining of cells persistently infected with BDV. Immunoprecipitation of p10 from BDV-infected cells coprecipitated the p40 nucleoprotein N and the 24-kDa viral phosphoprotein P. Transient transfection of noninfected cells showed that p10 and p40 can be coprecipitated and revealed that p10 localized in the cytoplasm was imported into the nucleus in the presence of the BDV p40 N. In vitro protein-protein interaction studies on solid phase showed the direct interaction of the p10 with the BDV N protein. The subcellular distribution of p10 and its interaction with p40 suggest that this protein may play a role in the nuclear replication and/or transcription of BDV. (+info)Pathogenesis of borna disease virus: granulocyte fractions of psychiatric patients harbor infectious virus in the absence of antiviral antibodies. (5/250)
Borna disease virus (BDV) causes acute and persistent infections in various vertebrates. During recent years, BDV-specific serum antibodies, BDV antigen, and BDV-specific nucleic acid were found in humans suffering from psychiatric disorders. Furthermore, viral antigen was detected in human autopsy brain tissue by immunohistochemical staining. Whether BDV infection can be associated with psychiatric disorders is still a matter of debate; no direct evidence has ever been presented. In the present study we report on (i) the detection of BDV-specific nucleic acid in human granulocyte cell fraction from three different psychiatric patients and (ii) the isolation of infectious BDV from these cells obtained from a patient with multiple psychiatric disorders. In leukocyte preparations other than granulocytes, either no BDV RNA was detected or positive PCR results were obtained only if there was at least 20% contamination with granulocytes. Parts of the antigenome of the isolated virus were sequenced, demonstrating the close relationship to the prototype BDV strains (He/80 and strain V) as well as to other human virus sequences. Our data provide strong evidence that cells in the granulocyte fraction represent the major if not the sole cell type harboring BDV-specific nucleic acid in human blood and contain infectious virus. In contrast to most other reports of putative human isolates, where sequences are virtually identical to those of the established laboratory strains, this isolate shows divergence in the region previously defined as variable in BDV from naturally infected animals. (+info)Inhibition of Borna disease virus replication by ribavirin. (6/250)
The guanosine analogue ribavirin was tested for antiviral activity in two neural cell lines, human oligodendrocytes and rat glia, against Borna disease virus (BDV) strains V and He/80. Ribavirin treatment resulted in lower levels of virus and viral transcripts within 12 h. Addition of guanosine but not adenosine resulted in a profound reduction of the ribavirin effect. Ribavirin appears to be an effective antiviral agent for treatment of BDV infection in vitro. A likely mechanism for its activity is reduction of the intracellular GTP pool, resulting in inhibition of transcription and capping of BDV mRNAs. (+info)T cell ignorance in mice to Borna disease virus can be overcome by peripheral expression of the viral nucleoprotein. (7/250)
Infection of neonates with Borna disease virus (BDV) induces severe meningoencephalitis and neurological disorder in wild-type but not in beta(2)-microglobulin-deficient mice of strain MRL (H-2(k)). Temporary in vivo depletion of CD8(+) T cells delayed BDV-induced disease for several weeks. Depletion of CD4(+) T cells had a similar beneficial effect, indicating that the BDV-induced neurological disorder in mice is a CD4(+) T cell-dependent immunopathological process that is mediated by CD8(+) T cells. Lymphocytes prepared from brains of diseased mice were mainly from the CD8(+) T cell subset. They showed up-regulation of activation markers and exerted strong MHC I-restricted cytotoxic activity against target cells expressing the BDV nucleoprotein p40. Infection of B10.BR (H-2(k)) or congenic C57BL/10 (H-2(b)) mice resulted in symptomless, lifelong persistence of BDV in the brain. Superinfection with a recombinant vaccinia virus expressing BDV p40 but not with other vaccinia viruses induced severe neurological disease and encephalitis in persistently infected B10.BR mice but not in persistently infected C57BL/10 mice, indicating that the disease-inducing T cell response is restricted to the nucleoprotein of BDV in H-2(k) mice. Our results demonstrate that the cellular arm of the immune system may ignore the presence of a replicating virus in the central nervous system until proper antigenic stimulation at a peripheral site triggers the antiviral response. (+info)Enhancement of Borna disease virus transcription in persistently infected cells by serum starvation. (8/250)
Transcription of Borna disease virus (BDV) in persistently infected MDCK (MDCK/BDV) cells increased in the fetal bovine serum free media as detected by Northern blot analysis. Especially, the amount of 1.9-kb RNA without cap formation at the 5' end and polyadenylation at the 3' end, increased as compared to other mRNA molecules of BDV. Growth arrest of MDCK/BDV cells observed in the condition of serum starvation might be important for increasing viral transcription. Since N-cadherin is the responsible factor for cell-to-cell contact, MDCK/BDV cells were cultured in calcium free medium which inhibits the interaction of N-cadherin. However, inhibition of cell-to-cell contact by N-cadherin is not effective on up regulation of viral transcription. Our finding in this study indicates that enhancement of BDV transcription by serum starvation is a useful technique for further investigation in understanding of mechanisms of BDV transcription. (+info)
Characterization of the Borna disease virus phosphoprotein, p2...
Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection<...
Detection and sequence analysis of borna disease virus p24 RNA...
Authentic Borna disease virus transcripts are spliced less efficiently than cDNA-derived viral RNAs - Academic Commons
Welcome to CDC stacks | Borna disease. - 15386 | Emerging Infectious Diseases
Development of a real-time PCR for in vivo diagnosis of feline Borna disease - Epsilon Archive for Student Projects
Neuron-glia interactions in the rat retina infected by Borna disease virus, Archives of Virology | 10.1007/s007050050010 |...
Low prevalence of Borna disease virus 1 (BoDV-1) IgG antibodies in humans from areas endemic for animal Borna disease of...
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Borna Disease Virus - LABOKLIN GMBH & CO.KG LABOR FÜR KLINISCHE DIAGNOSTIK
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W. Ian Lipkin
Lipkin, W. I; Hornig, M; Briese, T (2001). "Borna disease virus and neuropsychiatric disease--a reappraisal". Trends in ... "Does Borna Disease Virus Cause Mental Health? Stephanie Berger. Columbia University Mailman School of Public Health. January 31 ... Bode, L; Ludwig, H (2003). "Borna Disease Virus Infection, a Human Mental-Health Risk". Clinical Microbiology Reviews. 16 (3): ... "Borna disease is a neurotropic negative-strand RNA virus that infects a wide range of vertebrate hosts," causing "an immune- ...
Bicolored shrew
... white-toothed shrew is a natural reservoir species for the Borna disease virus which is the causative agent of Borna disease, a ... "Shrews as Reservoir Hosts of Borna Disease Virus". Emerging Infectious Diseases. 12 (4): 675-677. doi:10.3201/eid1204.051418. ... Kamhieh S, Flower RL (June 2006). "Borna disease virus (BDV) infection in cats. A concise review based on current knowledge". ... Rott, R.; Herzog, S.; Bechter, K.; Frese, K. (1991). "Borna disease, a possible hazard for man?". Archives of Virology. 118 (3- ...
Bornaviridae
"Borna Disease Virus Infection in Animals and Humans". Emerging Infectious Diseases. 3 (3): 343-352. doi:10.3201/eid0303.970311 ... Diseases associated with bornaviruses include Borna disease, a fatal neurologic disease of mammals restricted to central Europe ... Richt, JA; Rott, R (2001). "Borna disease virus: a mystery as an emerging zoonotic pathogen". Vet J. 161 (1): 24-40. doi: ... Borna disease was first identified in 1926 and its genome was isolated in 1990. In 1996, ICTV proposed the creation of the ...
Tupaia (mammal)
A study investigating the effects of the Borna disease virus on treeshrews has given new insight into neurological disease. ... Sprankel, H., Richarz, K., Ludwig, H. and Rott, R. (1978). Behavior Alterations in Tree Shrews Induced by Borna Disease Virus. ... Their susceptibility to viruses has also piqued interest in using them to study immune responses to infections such as ... Recent studies have used treeshrews to study infectious, metabolic, neurological, and psychiatric diseases, as well as cancers ...
Avian bornavirus
In general these viruses show only about 65% sequence identity with mammalian Borna disease virus 1 (BoDV-1). The overall ... "Novel Borna Virus in Psittacine Birds with Proventricular Dilatation Disease". Emerging Infectious Diseases. 14 (12): 1883-1886 ... Avian bornaviruses have been reported, yet not proven, as the cause of proventricular dilatation disease (PDD), a disease of ... "Use of Avian Bornavirus Isolates to Induce Proventricular Dilatation Disease in Conures". Emerging Infectious Diseases. 16 (3 ...
MiR-122
"Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells". Antiviral Res. 87 (2): 249- ... Jangra RK, Yi M, Lemon SM (2010). "Regulation of hepatitis C virus translation and infectious virus production by the microRNA ... other RNA viruses and viral mimetics (e.g. poly(I:C)). Recent studies have shown that replication of hepatitis C virus (HCV) is ... Biomarkers in Liver Disease. V. B. Patel and V. R. Preedy. Dordrecht, Springer Netherlands: ISBN 978-94-007-7675-3, page 193- ...
Animal model of autism
Pletnikov, M. V.; Moran, T. H.; Carbone, K. M. (2002). "Borna disease virus infection of the neonatal rat: Developmental brain ... Much research has been done into the use of a rat model to show how Borna virus infection, exposure to valproic acid in utero, ... Centers for Disease Control (2008-02-08). "Mercury and vaccines (thimerosal)". Retrieved 2011-08-01. Crawley, J. N. (2012). " ... Klauck, S. M.; Poustka, A. (2006). "Animal models of autism". Drug Discovery Today: Disease Models. 3 (4): 313-318. doi:10.1016 ...
Perforin
Nöske K, Bilzer T, Planz O, Stitz L (1998). "Virus-Specific CD4+ T Cells Eliminate Borna Disease Virus from the Brain via ...
Sue VandeWoude
... where she studied the virus associated with Borna disease. She joined the faculty of Colorado State University in 1990 and ... VandeWoude studies viruses including Feline Immunodeficiency Virus, Feline Leukemia Virus, and Feline Foamy Virus that infect ... Susan (Sue) VandeWoude is a veterinarian and researcher in the United States, specializing in viral diseases of cats. She is ...
Risk factors of schizophrenia
Polio, measles, varicella-zoster, rubella, herpes simplex virus type 2, maternal genital infections, Borna disease virus, and ... It is a pathogenic theory of disease in which it is thought that a proximal cause of certain cases of schizophrenia is the ... An updated meta-analysis on CNVs for schizophrenia published in 2015 expanded the number of CNVs indicated in the disease, ... 2010-10-26). "Disease-relevant autoantibodies in first episode schizophrenia". Journal of Neurology. 258 (4): 686-688. doi: ...
Mady Hornig
She directs the clinical core of an international investigation of the role of Borna disease virus in human mental illness and ... based on neonatal rat infection with Borna disease virus. In 2004, Hornig published a controversial paper concluding that, in a ... In the 1990s, Hornig investigated the potential link between the Borna virus and depression in humans. Hornig has been ... In 2008, she published a study concluding that there was no association between presence of measles vaccine virus in the gut of ...
Causes of autism
Laboratory rats infected with Borna disease virus show some symptoms similar to those of autism but blood studies of autistic ... Viruses have long been suspected as triggers for immune-mediated diseases such as multiple sclerosis but showing a direct role ... or whether they are secondary to the disease processes. As autoantibodies are found in diseases other than ASD, and are not ... Clinical Infectious Diseases. 2009;48(4):456-461. doi:10.1086/596476. PMID 19128068. Paul R. Parents ask: am I risking autism ...
Infections associated with diseases
Bode, L; Ludwig, H (2003). "Borna disease virus infection, a human mental-health risk". Clinical Microbiology Reviews. 16 (3): ... JC Virus and Simian Virus 40 Infection in Humans, and Association with Human Tumors". Polyomaviruses and Human Diseases. ... June 2010). "Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine". Cell ... Takahashi, M; Yamada, T (1999). "Viral etiology for Parkinson's disease--a possible role of influenza A virus infection". ...
Virus-Taxonomie
Borna Disease Virus, das Virus der Bornaschen Krankheit, mit Species Mammalian 1 orthobornavirus (Typus) u. a. ... Usutu-Virus - en. Usutu virus (USUV), Zika-Virus - en. Zika virus (ZIKV), sowie Gelbfieber-Virus - en. Yellow fever virus (YFV) ... Genus ‚Negevirus', mit Species ‚Blackford virus', ‚Bofa virus', ‚Buckhurst virus', ‚Marsac virus', sowie ‚Muthill virus'[53] ... Sorghum mosaic virus (SrMV), Lily-Mottle-Virus - en. Lily mottle virus (LMoV), sowie Sellerie-Virus Y - en. Apium virus Y (ApVY ...
Borna
... a family of viruses associated with Borna disease Borna disease virus Borna language (Democratic Republic of the Congo), a ... Borna may refer to: Borna, Leipzig, a town in Saxony, Germany Borna, a subdivision of Bahretal municipality, Saxony, German ... a Croatian masculine given name Bertin Borna (1930-2007), a Beninese politician Borna disease, an infectious neurological ... Borna Dam, an earthfill dam on Borna river near Ambejogai, Beed district, Maharashtra, India Borna (duke), the Duke of Dalmatia ...
Proventricular dilatation disease
Novel borna virus in psittacine birds with proventricular dilatation disease. Emerging infectious diseases 14(12), 1883-6.e ... Kristen Bole (2008-07-29). "UCSF researchers identify virus behind mysterious parrot disease". UCSF News Office. Archived from ... Proventricular dilatation disease (PDD) is an incurable probably viral disease of psittacine birds. It was first recognized and ... The virus can also affect the Purkinje cells of the heart, the adrenal medulla, the brain, and the spinal cord. On necropsy the ...
Borna disease
Although Borna disease viruses 1 and 2 are mainly seen as the causative agent of Borna disease in horses and other animals, ... Borna disease viruses 1 and 2 are neurotropic viruses and members of the Bornaviridae family within the Mononegavirales order. ... Borna disease, also known as sad horse disease, is an infectious neurological syndrome of warm-blooded animals, caused by Borna ... The virus name is derived from the town of Borna in Saxony, Germany, which suffered an epidemic of the disease in horses in ...
Borna disease virus
The ancestral virus seems likely to have been a high AT content virus. Borna disease was first described in 1885 as "heated ... The Borna disease viruses 1 and 2 (BoDV-1 and BoDV-2) are members of the species Mammalian 1 orthobornavirus and cause Borna ... "N-terminal domain of Borna disease virus G (p56) protein is sufficient for virus receptor recognition and cell entry". Journal ... Wolff T, Pfleger R, Wehner T, Reinhardt J, Richt JA (April 2000). "A short leucine-rich sequence in the Borna disease virus p10 ...
Orthomyxoviridae
Thogoto and Borna disease viruses". Virus Res. 95 (1-2): 3-12. doi:10.1016/S0168-1702(03)00159-X. PMID 12921991.. ... Influenza virus A Influenza A virus* H1N1, H1N2, H2N2, H3N1, H3N2, H3N8, H5N1, H5N2, H5N3, H5N8, H5N9, H7N1, H7N2, H7N3, H7N4, ... International Committee on Taxonomy of Viruses Index of Viruses - Orthomyxovirus (2006). In: ICTVdB-The Universal Virus ... "CIDRAP - Center for Infectious Disease Research and Policy. University of Minnesota.. *^ "Flu viruses 'can live for decades' on ...
RNA virus
Borna disease virus Family Filoviridae - includes Ebola virus, Marburg virus Family Mymonaviridae Family Nyamiviridae Family ... virus Extra small virus Goji berry chlorosis virus Harmonia axyridis virus 1 Hepelivirus Jingmen tick virus Le Blanc virus ... includes Yellow fever virus, West Nile virus, Hepatitis C virus, Dengue fever virus, Zika virus Family Fusariviridae Family ... Viruses portal Virus classification List of viruses Viral replication Positive/negative-sense Animal viruses Double-stranded ...
Category:Protein pages needing a picture
Borna disease virus. *BpuJI. *Bradykinin. *Bradykinin receptor. *Brain-specific angiogenesis inhibitor. *Branched chain amino ...
Virus classification
Borna disease virus Enveloped Helical ss(-) V 15. Arteriviridae Arterivirus, equine arteritis virus Enveloped Icosahedral ss IV ... Measles virus, mumps virus, respiratory syncytial virus, Rinderpest virus, canine distemper virus Enveloped Helical ss(-) V ... and foot-and-mouth virus), SARS virus, hepatitis C virus, yellow fever virus, and rubella virus. ... DNA virusesEdit. Further information: DNA virus. Viruses with a DNA genome, except for the DNA reverse transcribing viruses, ...
Influenza bahasa Indonesia, ensiklopedia bebas
Thogoto and Borna disease viruses". Virus Res. 95 (1-2): 3-12. doi:10.1016/S0168-1702(03)00159-X. PMID 12921991.. Parameter , ... Virus influenza C. Virus-virus tersebut memiliki kekerabatan yang jauh dengan virus parainfluenza manusia, yang merupakan virus ... Jenis-jenis virusSunting. Dalam klasifikasi virus, virus influenza termasuk virus RNA yang merupakan tiga dari lima genera ... Virus influenza A subtipe H10N7. Virus influenza BSunting. Genus ini memiliki satu spesies, yaitu virus influenza B. influenza ...
List of MeSH codes (C02)
... kyasanur forest disease MeSH C02.782.417.505 - lassa fever MeSH C02.782.417.560 - marburg virus disease MeSH C02.782.417.762 - ... borna disease MeSH C02.782.580.250 - filoviridae infections MeSH C02.782.580.250.400 - hemorrhagic fever, ebola MeSH C02.782. ... border disease MeSH C02.782.350.675.106 - bovine virus diarrhea-mucosal disease MeSH C02.782.350.675.200 - classical swine ... marburg virus disease MeSH C02.782.580.600 - paramyxoviridae infections MeSH C02.782.580.600.080 - avulavirus infections MeSH ...
Influenza
Thogoto and Borna disease viruses". Virus Research. 95 (1-2): 3-12. doi:10.1016/S0168-1702(03)00159-X. PMID 12921991.. ... In virus classification, influenza viruses are RNA viruses that make up four of the seven genera of the family Orthomyxoviridae ... These viruses are only distantly related to the human parainfluenza viruses, which are RNA viruses belonging to the ... how the virus produces disease (pathogenesis), host immune responses, viral genomics, and how the virus spreads (epidemiology ...
List of MeSH codes (B04)
... borna disease virus MeSH B04.820.455.300 - filoviridae MeSH B04.820.455.300.200 - ebola-like viruses MeSH B04.820.455.300.650 ... borna disease virus MeSH B04.909.777.455.300 - filoviridae MeSH B04.909.777.455.300.200 - ebola-like viruses MeSH B04.909. ... border disease virus MeSH B04.820.250.700.150 - diarrhea viruses, bovine viral MeSH B04.820.250.700.150.100 - diarrhea virus 1 ... african horse sickness virus MeSH B04.820.630.550.100 - bluetongue virus MeSH B04.820.630.550.400 - hemorrhagic disease virus, ...
Virus
Many serious diseases such as rabies, Ebola virus disease, AIDS (HIV), avian influenza, and SARS are caused by viruses. The ... January 1999). "High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health ... Viruses are important pathogens of livestock. Diseases such as foot-and-mouth disease and bluetongue are caused by viruses. ... A virus has either a DNA or an RNA genome and is called a DNA virus or an RNA virus, respectively. The vast majority of viruses ...
Virus
Many serious diseases such as Ebola virus disease, AIDS, avian influenza, and SARS are caused by viruses. The relative ability ... Chen C, Chiu Y, Wei F, Koong F, Liu H, Shaw C, Hwu H, Hsiao K. High seroprevalence of Borna virus infection in schizophrenic ... I: dsDNA viruses. II: ssDNA viruses. III: dsRNA viruses. IV: (+)ssRNA viruses. V: (−)ssRNA viruses. VI: ssRNA-RT viruses. VII: ... A virus has either a DNA or an RNA genome and is called a DNA virus or an RNA virus, respectively. The vast majority of viruses ...
Virus
Many serious diseases such as Ebola virus disease, AIDS, avian influenza, and SARS are caused by viruses. The relative ability ... Chen C, Chiu Y, Wei F, Koong F, Liu H, Shaw C, Hwu H, Hsiao K. High seroprevalence of Borna virus infection in schizophrenic ... A virus has either a DNA or an RNA genome and is called a DNA virus or an RNA virus, respectively. The vast majority of viruses ... Viruses are important pathogens of livestock. Diseases such as foot-and-mouth disease and bluetongue are caused by viruses.[208 ...
人畜共通傳染病 - 維基百科,自由的百
科薩努爾森林病(英語:Kyasanur forest disease) *KFDV(英語:Kyasanur forest disease virus) ... 玻那病毒Borna virusinfection. *馬爾堡病毒. *裂谷熱Rift Valley fever ... N, 580-629(英語:List of ICD-9 codes 580-629: diseases of the genitourinary system)). *Urologic disease(英語:Urologic disease) *腎病變 ... G, 320-359(英語:List of ICD-9 codes 320-359: diseases of the nervous system)). *神經系統疾
Execution of Imam Khomeini's Order
... virus yjc.ir The Iranian vaccine neutralizes the British virus mehrnews.com The Iranian vaccine neutralized the British virus ... "The country's first special pharmaceutical economic zone was registered in Alborz". Borna News. Retrieved 3 September 2018. " ... research on the medicine of the disease, launching the 4030 phone line with the help of 2,200 doctors and paramedics for ... the results show that this vaccine also neutralizes the British mutated COVID-19 virus. The vaccine is currently in phase 2 and ...
Barakat Pharmaceutical Group
... using in the treatment of high-dose diseases such as Multiple sclerosis, blood diseases and cancer, "Research and development ... The Iranian vaccine neutralizes the British virus yjc.ir The Iranian vaccine neutralizes the British virus mehrnews.com Iranian ... CS1 maint: discouraged parameter (link) "The First Special Economic Zone of the Country Recorded in Alborz". Borna News. 3 ... Also, "cell therapy" by producing five products for the treatment of skin and heart disease and knee arthritis, production of " ...
Wheat
There are many wheat diseases, mainly caused by fungi, bacteria, and viruses. Plant breeding to develop new disease-resistant ... Pronin, Darina; Borner, Andreas; Weber, Hans; Scherf, Ann (10 July 2020). "Wheat (Triticum aestivum L.) Breeding from 1891 to ... Both of these diseases are soil borne. Stem rust diseases: Caused by basidiomycete fungi e.g. Ug99 Viral diseases: Wheat ... A wide range of organisms infect wheat, of which the most important are viruses and fungi. The main wheat-disease categories ...
COVID-19 pandemic in Croatia
Concerns over the virus began as soon as it began its rapid rise in China and its effects on the international scale became ... A day after, Croatian player Borna Ćorić confirmed he was infected as well, with organizers urging fans and citizens who were ... They left self-isolation on 18 March after none of them showed symptoms of the disease. On 24 March, Croatia national football ... On 12 March, the first recovery was reported, and on 18 March, the first death from the virus was confirmed. The pandemic in ...
Obstructive sleep apnea
The Epstein-Barr virus, for example, is known to be able to dramatically increase the size of lymphoid tissue during acute ... Stroke and other cardiovascular diseases are related to OSA, and those under the age of 70 have an increased risk of early ... Borner, Urs; Tschopp, Kurt (2021-03-30). "Night-to-night variability in obstructive sleep apnea using peripheral arterial ... This repeated brain hypoxia is also considered to be a cause of Alzheimer's disease. Diagnosis of obstructive sleep apnea is ...
Aral Sea
In 1971, weaponized smallpox from the island reached a nearby ship, which then allowed the virus to spread to the city of Aral ... In June 2007, BBC World broadcast a documentary called Back From the Brink? made by Borna Alikhani and Guy Creasey, which ... and infectious diseases are common ailments. Liver, kidney, and eye problems can also be attributed to the toxic dust storms. ... Archives of Disease in Childhood. 88 (11): 966-968. doi:10.1136/adc.88.11.966. PMC 1719339. PMID 14612357. Crighton, Eric James ...
InfectionAbstractPathogenesisAntibodies to Borna diseaBornaviridaeRatsViral diseaseDetectionSchizophreniaAnalysis of bornaHumansInfectionsSheepStrainsProteinsBornavirusPhosphoproteinCausative agentEmerging InfectioMononegaviralesHorses in 1885AvianSaxonySpeciesEndogenousNeuropsychiatric disordersMammalsInfectsProtein2019Encephalitis associatedPsittacine birdsPsychiatricReplicationGenomeNeuronalFatalWhite-tootheProventricularResearchersNeurotropic virusNaturally infectedPathogenGlycoproteinSingle strandedOccursVariantsGenes
Infection38
- Persistent Borna Disease Virus infection changes expression and function of astroglial gap junctions in vivo and in vitro. (nih.gov)
- Neonatal Borna Disease Virus (BDV) infection of the Lewis rat brain leads to dentate gyrus (DG) degeneration, underlying mechanisms are not fully understood. (nih.gov)
- RT-PCR and Western blot analysis of forebrain (FB) samples revealed a virus dependent reduction of both Cx types 8 but not 4 weeks post infection (p.i. (nih.gov)
- The research interest in BDV moved to include Asia in the middle of the 1980s, with specific interests in virus infection and human neuropsychiatric diseases. (asmscience.org)
- The direct effects and mechanisms of BDV infection on brain dysfunction, in the absence of immunopathological brain injury, need to be determined for a better understanding of BD pathogenesis but also for a better understanding of the links between BDV, human infection, and noninflammatory neuropsychiatric diseases. (asmscience.org)
- Besides its significance for the practitioner, Boma disease virus infection remains to be unique as a disease model: it allows to study most diverse alterations in neurobiological processes. (scialert.net)
- Borna disease virus infection impairs synaptic plasticity. (inserm.fr)
- While empirical studies have found that an endogenous bornavirus-like element derived from viral nucleoprotein (itEBLN) in the ground squirrel genome shows antiviral effect on virus replication and de novo infection, the antiviral mechanism, dynamics, and quantitative effect of itEBLN remain unknown. (asm.org)
- The effect of interferon (IFN) on infection and maintenance of persistent infection of Borna disease (BD) virus in cell cultures was investigated. (microbiologyresearch.org)
- Acutely BD virus-infected primary rabbit brain and rat lung cells produced significant levels of interferon detectable 3 days post-infection in the culture supernatants. (microbiologyresearch.org)
- Exogenous homologous IFN completely inhibited the expression of BD virus antigen in acutely infected rabbit brain cells, when added during the first 24 h after infection. (microbiologyresearch.org)
- IFN added later (2 to 6 days post-infection) reduced virus titres to different degrees depending on the onset of treatment. (microbiologyresearch.org)
- Thus, MDCK cells, which could not be induced to produce IFN, can be readily persistently infected with BD virus in vitro , and exogenous IFN did not appear to influence persistent BD virus infection. (microbiologyresearch.org)
- Neonatal Borna Disease Virus (BDV) infection in rats leads to a neuronal loss in the cortex, hippocampus and cerebellum. (biomedcentral.com)
- The data demonstrate for the first time that a non-lytic persistent virus infection of neurons activates microglia long before any measurable neuronal loss. (biomedcentral.com)
- Carbone, K. M. / Hematologic consequences of Borna disease virus infection of rat bone marrow and thymus stromal cells . (elsevier.com)
- Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disorders. (elsevier.com)
- This model utilizes neonatal Borna disease virus (BDV) infection of the rat brain as a unique experimental teratogen to study the pathogenesis of neurodevelopmental damage. (elsevier.com)
- The progression of a clinically manifested infection is lethal (duration of the disease usually 1 - 3 weeks). (laboklin.com)
- Borna disease virus (BDV) infection in horses either occurs as persistent infection without any clinical symptoms, or is associated with various clinical entities. (fu-berlin.de)
- Whether Borna disease virus (BDV-1) is a human pathogen remained controversial until recent encephalitis cases showed BDV-1 infection could even be deadly. (biomedcentral.com)
- On 31 August 2016 the autonomous Community of Madrid, Spain, reported two cases of infection with Crimean-Congo haemorrhagic fever (CCHF) virus. (europa.eu)
- Following infection, individuals may develop Borna disease, or may remain subclinical, possibly acting as a carrier of the virus. (wikipedia.org)
- There is some evidence that there may be a relationship between BoDV-1 infection and psychiatric disease. (wikipedia.org)
- HIV/AIDS and Borna Disease Virus (BDV) in animals help to bring the infection-based model of schizophrenia to the realm of scientific imagination Viruses can influence the human genome. (thefreedictionary.com)
- In The Neurobiology of Autism (Bauman and Kemper 2005), the authors draw parallels in neurobiology and behavior with autism and another type of infection, neonatal Borna disease virus. (thefreedictionary.com)
- Infection of newborn Lewis rats with Borna disease virus (neonatal Borna disease [NBD]) results in cerebellar damage without the cellular inflammation associated with infections in later life. (biomedsearch.com)
- Borna disease virus infection of adult and neonatal rats: models for neuropsychiatric disease. (medigraphic.com)
- Ludwig H, Bode L. Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology. (medigraphic.com)
- Varied prevalence of Borna disease virus infection in Arabic, thoroughbred and their cross-bred horses in Iran. (medigraphic.com)
- Borna disease appears as a sporadic infection affecting small numbers of animals each year. (cdc.gov)
- Human infection with foamy viruses. (uniklinik-freiburg.de)
- The researchers in this study aimed to determine the relationship between infection with Borna Disease Virus (BDV) and schizophrenia and other mood disorders, with respect to symptom subtypes and clinical time course. (stanford.edu)
- Discovered more than 40 years ago, with an efficient vaccine developed against it, the Human Hepatitis B virus (HBV) infection is still a frequent viral disease and a major cause of chronic liver pathogenesis. (frontiersin.org)
- It's an idea to shake up our notion of mind and body: That a virus or bacterial infection could lead to a personality-changing mental illness. (chicagotribune.com)
- With depression, the researchers are not sure whether the fault lies with an actual virus or an auto-immune condition that mimics a viral infection. (chicagotribune.com)
- Anti-idiotypic antibody as potential serodiagnostic reagent for detection of bluetongue virus infection. (asm.org)
- Differential genes expression in rats-hippocampus and -cerebellum after Borna disease virus infection. (mpg.de)
Abstract1
- abstract = "Borne disease virus (BDV) was previously believed to have a strict tropism for the nervous system. (elsevier.com)
Pathogenesis4
- Recent discoveries to diagnose BDV-infections intra vitam indicate blood mononuclear cells (PBMCs) to play a key-role in pathogenesis of disease symptoms of horses and man. (fu-berlin.de)
- Gosztonyi G, Ludwig H. Borna disease--neuropathology and pathogenesis. (medigraphic.com)
- Although many viruses use various strategies to control the cell death machinery by encoding anti-apoptotic virulence factors, it is now becoming clear that, in addition to their role in inhibiting apoptosis, these factors function in multiple immune and metabolic pathways to promote fitness and pathogenesis. (jove.com)
- The pathogenesis of Borna disease (BD) has been proposed to be immune-mediated, mainly through the effects of cytotoxic T cells. (maxshouse.com)
Antibodies to Borna disea1
- In serum samples from diseased cats, antibodies to Borna disease virus were demonstrated. (maxshouse.com)
Bornaviridae5
- The Borna virus is a non-segmented, enveloped RNA virus which constitutes the only member of the family Bornaviridae. (laboklin.com)
- Borna disease viruses 1 and 2 are neurotropic viruses and members of the Bornaviridae family within the Mononegavirales order. (wikipedia.org)
- Before this discovery, the family Bornaviridae contained only 1 species, Borna disease virus (BDV). (thefreedictionary.com)
- Avian bornavirus (ABV) is a newly discovered member of the family Bornaviridae that has been associated with the development of a lethal neurologic syndrome in birds, termed proventricular dilatation disease (PDD). (cdc.gov)
- Borna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. (nel.edu)
Rats5
- We now report the identification of BDV RNA end infectious virus in thymus cells from rats infected either as neonates (PTI- NB) or as adults (4 weeks of age). (elsevier.com)
- We also report the association between BDV in the thymus with the lack, or loss, of encephalitis in neonatally inoculated rats or adult-inoculated rats during the chronic stage of disease. (elsevier.com)
- Neutralizing antibodies in Borna disease virus-infected rats. (medigraphic.com)
- Identification of differentially expressed genes in brains of newborn Borna disease virus-infected rats in the absence of inflammation. (uniklinik-freiburg.de)
- Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with Borna disease virus. (columbia.edu)
Viral disease3
- Proventricular dilatation disease (PDD) is a suspected viral disease that has been given many other names over the years, including macaw wasting disease (as it was thought to be prevalent in this species), neuropathic ganglioneuritis, and lymphoplasmocytic ganglioneuritis. (avianavenue.com)
- Borna disease , a viral disease of warm-blooded animals, notably horses and sheep , characterized by inflammation of the brain and spinal cord . (britannica.com)
- A viral disease transmitted by mosquitoes and is endemic in tropical and subtropical regions. (citizendium.org)
Detection5
- The detection of live virus and mRNA (PCR or in situ hybridization) strongly indicates virus replication in monocytes. (fu-berlin.de)
- The hypothesis that microbial infections may be linked to mental disorders has long been addressed for Borna disease virus (BDV), but clinical and epidemiological evidence remained inconsistent due to non-conformities in detection methods. (beds.ac.uk)
- Rapid detection of herpes simplex virus and varicella-zoster virus infections by real-time PCR. (uniklinik-freiburg.de)
- Comparison of commercial enzyme immunoassay kits with plaque reduction neutralization test for detection of measles virus antibody. (asm.org)
- Detection of Borna disease virus RNA in formalin-fixed, paraffin-embedded brain tissues by nested PCR. (asm.org)
Schizophrenia2
- Borna disease virus (BDV) is well known as a neurotropic virus، however، its role in human neurological diseases such as schizophrenia and bipolar disorder is still unclear. (magiran.com)
- In humans, the virus has been linked (albeit inconclusively) to various psychiatric disorders including schizophrenia. (scienceblogs.com)
Analysis of borna1
- A Bayesian analysis of Borna disease virus 1 suggests that the current strains diversified ~300 years ago and that avian-host bornaviruses evolved considerably earlier than this. (wikipedia.org)
Humans13
- It has been a controversial issue whether this virus also infects humans and is there linked to neuropsychiatric disorders. (laboklin.com)
- Many researchers are now investigating the claim that a simple virus known to infect horses, could be a major factor in the cause of mental illness in humans. (sciencephoto.com)
- Borna disease virus (BDV) is an evolutionary old RNA virus, which infects brain and blood cells of humans, their primate ancestors, and other mammals. (biomedcentral.com)
- Some studies have claimed a link between exposure to the Borna disease virus and mental illness in humans, but such a connection has not been conclusively proven. (britannica.com)
- Borna disease virus-1 (BoDV-1) was recently discovered as cause of severe and often fatal encephalitis in humans. (rki.de)
- Due to the fact that this would be a first incidence of a previously unknown disease, there is no definitive method of testing for VSBV-1, or for Borna disease viruses in humans. (healthmap.org)
- The role of BoDV-1 and -2 in human illness is controversial and it is yet to be established whether BoDV-1 or -2 cause any overt disease in humans. (wikipedia.org)
- Borna virus has been detected in humans, and researchers have presented evidence connecting these infections with psychiatric disorders. (wikipedia.org)
- Humans and viruses have been coevolving for millennia. (pnas.org)
- Insect-borne virus, of the genus Alphavirus , that is transmitted to humans by virus-carrying Aedes mosquitoes. (citizendium.org)
- DNA viruses that cause upper respiratory tract infections, conjunctivitis, and other infections in humans. (citizendium.org)
- The virus has a predilection for the hypothalamus -- the part of the brain that, in humans, mediates our moods," Amsterdam says. (chicagotribune.com)
- That led Amsterdam and Hornig-Rohan to start looking for this virus in humans. (chicagotribune.com)
Infections12
- It is more difficult to disclose infections by growing the virus in tissue culture and by animal inoculation. (scialert.net)
- The ability of Boma disease virus to cause persistent infections of neurons most probably plays the key role in pathogenetic events. (scialert.net)
- The study published today in the renowned medical journal „The Lancet Infectious Diseases" collects and characterizes known human infections with Borna Disease Virus (BoDV-1). (idw-online.de)
- This document assesses the risk associated with the outbreak of Zika virus infections, considered as an emerging disease, to public health in the EU/EEA and the risk to EU/EEA citizens in order to anticipate future developments. (europa.eu)
- Counter-claims state that Borna virus infections are not cleared by amantadine. (wikipedia.org)
- Representing a major addition to the world literature on the subject, Viral Infections and Global Change explores trends of paramount concern globally, regarding the emergence and reemergence of vector-borne and zoonotic viruses. (wiley.com)
- Viral Infections and Global Change is an indispensable resource for research scientists, epidemiologists, and medical and veterinary students working in ecology, environmental management, climatology, neurovirology, virology, and infectious disease. (wiley.com)
- Bode L, Riegel S, Lange W, Ludwig H. Human infections with Borna disease virus: seroprevalence in patients with chronic diseases and healthy individuals. (medigraphic.com)
- Bode L, Durrwald R, Ludwig H. Borna virus infections in cattle associated with fatal neurological disease. (medigraphic.com)
- The unfolded protein response in virus infections. (frontiersin.org)
- Researchers are finding evidence that some diseases with only psychological symptoms could be triggered by infections or abnormalities of the immune system. (chicagotribune.com)
- PC inhibitors are suggested as promising antiviral drugs for quite a number of viruses causing severe infections. (springer.com)
Sheep13
- A similar disease had been observed in horses, sheep, and cattle for more than 100 years. (cdc.gov)
- Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. (sciencemag.org)
- BoDV-1, which has long been known as the causative agent of Borna disease in horses, sheep and other mammals, was first identified as the cause of severe human encephalitis in 2018. (idw-online.de)
- It is of clinical relevance particularly in horses, in cats (where the disease is also called "staggering disease") and in sheep. (laboklin.com)
- this disease has been reported for over two centuries ago in horses, sheep and cats in Central Europe and some regions of Asia. (scirp.org)
- BoDV-1 is known to cause neurological disease in horses and sheep mainly in South and Central Germany. (rki.de)
- Borna diseases viruses 1 and 2 appear to have wide host ranges, having been detected in horses, cattle, sheep, dogs and foxes. (wikipedia.org)
- citation needed] Borna disease in sheep and horses arises after a four-week incubation period followed by the development of immune-mediated meningitis and encephalomyelitis. (wikipedia.org)
- The most common causes for viral encephalitis in sheep include maedi-visna virus, Borna disease virus, and rabies virus. (thefreedictionary.com)
- Borna disease (BD) is a fatal neurologic disorder in horses and sheep. (thefreedictionary.com)
- Vahlenkamp TW, Konrath A, Weber M, Muller H. Persistence of Borna disease virus in naturally infected sheep. (medigraphic.com)
- Lundgren AL, Czech G, Bode L, Ludwig H. Natural Borna disease in domestic animals others than horses and sheep. (medigraphic.com)
- BDV causes a neurologic syndrome, Borna disease, which is restricted to central Europe, where it is found primarily in horses and sheep. (cdc.gov)
Strains4
- Pyrosequencing of cDNA from brains of parrots with proventricular dilatation disease (PDD), an unexplained fatal inflammatory central, autonomic, and peripheral nervous system disease, showed 2 strains of a novel Borna virus. (elsevier.com)
- Four strains of BDV have been described: Borna V, Borna HE/80, Borna No/98 and Borna H1766. (scirp.org)
- Strain H1766 has 95% - 98% homology with strains V and He/80, and only 81% with Borna No/98. (scirp.org)
- The ion channel blockers amantadine and rimantadine are of limited use because of a lack of activity against influenza B virus, side effects, and the rapid emergence of resistant virus strains ( 9 ). (asm.org)
Proteins4
- To favor their replication, viruses express proteins that target diverse mammalian cellular pathways. (sigmaaldrich.com)
- These studies provided insights into how NNS RNA viruses synthesize 5′-capped mRNAs using their RNA-dependent RNA polymerase L proteins equipped with an unconventional mRNA capping enzyme, namely GDP polyribonucleotidyltransferase (PRNTase), domain. (frontiersin.org)
- PRNTase or PRNTase-like domains are evolutionally conserved among L proteins of all known NNS RNA viruses and their related viruses belonging to Jingchuvirales , a newly established order, in the class Monjiviricetes , suggesting that they may have evolved from a common ancestor that acquired the unique capping system to replicate in a primitive eukaryotic host. (frontiersin.org)
- Alternatively, agents preventing cleavage of viral surface (glyco)proteins block fusion capacity and multicyclic virus replications. (springer.com)
Bornavirus3
- In this study, we experimentally and theoretically investigated the dynamics of how an extant bornavirus, Borna disease virus 1 (BoDV-1), spreads and replicates in uninfected, BoDV-1-infected, and itEBLN-expressing cultured cells. (asm.org)
- The new virus, which has been provisionally termed 'variegated squirrel 1 bornavirus' or VSBV-1, was found to be unique from the previously known and described bornaviruses (1). (healthmap.org)
- Almost all of these hidden sequences match the N gene of the most famous bornavirus - BDV or Borna disease virus. (scienceblogs.com)
Phosphoprotein3
- CiteSeerX - Borna Disease Virus Phosphoprotein Represses p53-Mediated. (yasni.com)
- Modulation of Borna Disease Virus Phosphoprotein Nuclear Localization. (yasni.com)
- Active Borna Disease Virus polymerase complex requires a distinct nucleoprotein-to-phosphoprotein ratio but no viral X protein. (uniklinik-freiburg.de)
Causative agent4
- The causative agent was later found to be a negative-stranded RNA virus, which may also be a human pathogen. (cdc.gov)
- This virus is the causative agent of congenital disorder of lambs and reproductive problems in ewes. (kitpcr.com)
- It was first described as the causative agent of a neurologic disease outbreak among horses in the German town of Borna in the 1800s (4, 8). (healthmap.org)
- Although Borna disease viruses 1 and 2 are mainly seen as the causative agent of Borna disease in horses and other animals, they are also controversially discussed as human infectious agents and therefore as potential zoonotic agents. (wikipedia.org)
Emerging Infectio2
- Emerging Infectious Diseases , 15 (9), 1452. (cdc.gov)
- Emerging Infectious Diseases , 14 (12), 1883-1886. (elsevier.com)
Mononegavirales7
- It is a linear negative-sense single stranded RNA virus in the order Mononegavirales. (wikipedia.org)
- These are the only animal viruses within the order Mononegavirales to do this. (wikipedia.org)
- Borna disease virus (BDV), the prototype of a new family within the order Mononegavirales, is unusual in its nuclear localization for replication and transcription and use of RNA splicing for gene expression. (asm.org)
- Borna disease virus (BDV) is an enveloped virus with a nonsegmented negative-strand RNA genome whose organization is characteristic of Mononegavirales. (eurekamag.com)
- Non-segmented negative strand (NNS) RNA viruses belonging to the order Mononegavirales are highly diversified eukaryotic viruses including significant human pathogens, such as rabies, measles, Nipah, and Ebola. (frontiersin.org)
- The order Mononegavirales comprises highly diversified eukaryotic viruses with a monopartite negative strand RNA genome (rarely bipartite genomes), which includes important human pathogens [e.g., rabies virus (RABV), measles virus (MeV), Nipah virus (NiV), human respiratory syncytial virus (HRSV), Ebola virus (EBOV)] ( Lamb, 2013 ). (frontiersin.org)
- Virus of the Mononegavirales species that causes Borna disease. (citizendium.org)
Horses in 18853
- Borna disease was first described in 1885 as "heated head disease" of cavalry horses in 1885 in the town of Borna, Germany. (wikipedia.org)
- The virus name is derived from the town of Borna in Saxony, Germany, which suffered an epidemic of the disease in horses in 1885. (wikipedia.org)
- tT was actually named for the town of Borna, Germany, where a killer epidemic of cavalry horses in 1885 led to its discovery. (scienceblogs.com)
Avian4
- In 2008, identification of the previously unknown avian Borna virus (ABV) in birds infected with PDD was achieved for the first time. (laboklin.com)
- Avian Borna viruses are RNA viruses which show high genetic divergence. (laboklin.com)
- We will speak about Avian Borna Virus in an upcoming section). (avianavenue.com)
- Avian bornaviruses, a group of related viruses, have been reported, yet not proven, as the cause of proventricular dilatation disease (PDD), a disease of pet parrots. (wikipedia.org)
Saxony3
- Borna disease virus was named after the town of Borna in Saxony, southeastern Germany, where in 1885 many horses in a German cavalry regiment died of a fatal neurologic disease. (cdc.gov)
- Its name derives from the city in Saxony where the condition was first described in 1894, but the disease occurs in europe , N. africa , and the Near East. (lookfordiagnosis.com)
- In 2015, German officials reported a cluster of three acute fatal encephalitis cases in the Saxony-Anhalt region to the Early Warning and Response System of the European Center for Disease Control (ECDC) (4). (healthmap.org)
Species12
- The Borna disease viruses 1 and 2 (BoDV-1 and BoDV-2) are members of the species Mammalian 1 orthobornavirus and cause Borna disease in mammals. (wikipedia.org)
- Horse and human P24 have no species-specific amino acid residues, suggesting that the two viruses are related. (wikipedia.org)
- The great adaptability of the virus to different animal species and its affinity for neurons allow to investigate clinical alterations involving the CNS and to quantitate the virological and immunological interactions of the agent with nerve cells in the brain and the eye. (scialert.net)
- Numerous species of mammals are susceptible to this virus. (laboklin.com)
- The disease has been identified in a wide variety of birds, including 80 species of psittacines, toucans, honey creepers, weaver finches, water fowl, raptors and passerines. (avianavenue.com)
- Borna disease, also known as sad horse disease, is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease viruses 1 and 2 (BoDV-1/2), both of which are members of the species Mammalian 1 orthobornavirus. (wikipedia.org)
- It is considered a serious disease because many of these birds are highly endangered, and several affected species depend on captive breeding for their survival. (cdc.gov)
- Family of double-stranded DNA viruses with icosahedral symmetry, usually found in the respiratory tract of the host species and often associated with respiratory diseases. (citizendium.org)
- Species of the genus Orthohepadnavirus , characterized by the causing the disease Hepatitis B, which can also lead to cirrhosis and hepatocellular carcinoma, and is transmitted by contaminated blood or blood derivatives. (citizendium.org)
- Prevalence studies of rodents collected in Turkey revealed 6% seropositivity to Puumala virus in Microtus voles and no appearance of hantavirus antibodies in the Apodemus species of rodents (9). (thefreedictionary.com)
- Borna disease virus (BDV) is a neurotropic agent with capacity to cause encephalomyelitis in a wide range of animal species, including horses and cats. (maxshouse.com)
- Newcastle disease is caused by a paramyxovirus, which can affect all species, and causes tremors, paralysis, and opisthotonos (where the head and tail are bent upward while the abdomen is pushed down). (mickaboo.org)
Endogenous3
- IMPORTANCE Accumulating evidence suggests that some endogenous viral elements (EVEs), including endogenous retroviruses and endogenous nonretroviral virus elements, have acquired functions in the host as a result of long-term coevolution. (asm.org)
- As a result, Horie and Honda christened their newfound sequences as EBLNs (or "endogenous Borna-like N" elements). (scienceblogs.com)
- 2010. Endogenous non-retroviral RNA virus elements in mammalian genomes. (scienceblogs.com)
Neuropsychiatric disorders1
- Comments on the article 'Borna Disease Virus in Human Brains with a Rare Form of Hippocampal Degeneration But Not in Brains of Patients with Common Neuropsychiatric Disorders,' by M. Czygan, W. Hallensleben et al, published in the 1999 issue of the 'Journal of Infectious Diseases. (ebscohost.com)
Mammals2
- This virus triggers the co-called Borna disease in mammals and the proventricular dilatation disease in birds. (laboklin.com)
- Viruses of the Parvoviridae family, that contain DNA in an icosahedral protein shell and cause disease in many vertebrates, especially mammals such as dogs and cattle. (citizendium.org)
Infects1
- The virus infects neurons and astrocytes, and the resulting disease appears to be mediated by an immunopathologic response of the host to the virus. (cdc.gov)
Protein6
- Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential. (sigmaaldrich.com)
- One salient example is the X protein of Borna disease virus, which is expressed both at the mitochondria and in the nucleus. (sigmaaldrich.com)
- Unprocessed envelope protein p57 is thought to be involved in attachment of the virus to its cell surface receptor. (cusabio.com)
- An Interferon-gamma-binding protein of novel structure encoded by the fowlpox virus. (uniklinik-freiburg.de)
- Bunyamwera virus nonstructural protein NSs counteracts interferon regulatory factor 3-mediated induction of early cell deaath. (uniklinik-freiburg.de)
- Identification of a novel C-terminal cleavage of Crimean-Congo hemorrhagic fever virus PreGN that leads to generation of an NSM protein. (springer.com)
20191
- The risk for EU/EEA citizens to become infected with communicable diseases during the 2019 hajj is considered low, thanks to the vaccination requirements for travelling to Makkah (Mecca) and the Saudi Arabian preparedness plans that address the management of health hazards during and after hajj. (europa.eu)
Encephalitis associated1
- Fatal Encephalitis Associated with Borna Disease Virus 1. (nih.gov)
Psittacine birds1
- An epornitic of this disease is currently occurring in imported and captive-bred psittacine birds in North America and Europe. (avianavenue.com)
Psychiatric6
- Consequently, debate about the role of BDV in psychiatric diseases remains alive. (wikipedia.org)
- The impact of Borna Disease virus (BDV) in Asian psychiatric patients remains to be clear. (org.ir)
- However, not all researchers consider the link between BoDV-1 and human psychiatric disease to be conclusively proven. (wikipedia.org)
- Borna disease virus circulating immunocomplex positivity and psychopathology in psychiatric patients in the Czech Republic. (nel.edu)
- State psychiatric hospitals used to be filled with people who had tertiary syphilis," an infectious disease, he points out. (chicagotribune.com)
- Serum autoantibody against the muscarinic cholinergic receptor (mAChR) was increased in some patients with chronic fatigue syndrome (CFS) or psychiatric disease. (ebscohost.com)
Replication7
- Quantifying antiviral effect based on time course data sets, we found that the antiviral effects of itEBLN are estimated to be 75% and 34% on intercellular virus spread and intracellular virus replication, respectively. (asm.org)
- This discrepancy between intercellular virus spread and intracellular viral replication suggests that viral processes other than the replication of viral ribonucleoprotein complex (RNP) contributed to the suppression of virus spread in itEBLN-expressing cells. (asm.org)
- Over the past 40 years, vesicular stomatitis virus (VSV), closely related to rabies virus, has served as a paradigm to study the fundamental molecular mechanisms of transcription and replication of NNS RNA viruses. (frontiersin.org)
- Replication of primate foamy viruses in natural and experimental hosts. (uniklinik-freiburg.de)
- Virus classification is based mainly on phenotypic characteristics, including morphology , nucleic acid type, mode of replication, host organisms , and the type of disease they cause. (wikidoc.org)
- These groups are designated by Roman numerals and separate viruses based on their mode of replication, and genome type. (wikidoc.org)
- Baltimore classification (first defined in 1971) is a classification system which places viruses into one of seven groups depending on a combination of their nucleic acid ( DNA or RNA ), strandedness (single-stranded or double-stranded), and method of replication . (wikidoc.org)
Genome6
- Nonetheless, the virus' genome has been characterised. (wikipedia.org)
- Borna disease virus (BDV) is a non-segmented, negative-strand RNA virus that replicates and transcribes its genome in the nucleus of infected cells. (columbia.edu)
- Borna Disease Virus (BDV) is an enveloped virus with a negative-strand RNA, non-segmented, non cytolytic and neurotrophic, with a genome of approximately 8.9 Kb. (scirp.org)
- Classifying viruses according to their genome means that those in a given category will all behave in a similar fashion, offering some indication of how to proceed with further research. (wikidoc.org)
- The human genome is littered with the remains of viruses that, in ages past, integrated their genes into the DNA of our ancestors. (scienceblogs.com)
- Background: Two large-scale genome-wide association studies have identified rs610932 and rs670139 polymorphisms within the MS4A gene cluster as being significantly associated with susceptibility to Alzheimer's disease (AD) in those with European ancestry. (eurekaselect.com)
Neuronal4
- The mechanisms whereby Borna disease virus (BDV) can impair neuronal function and lead to neurobehavioral disease are not well understood. (inserm.fr)
- This question is of importance since BDV is a non-lytic neurotropic virus and does not kill neurons in vitro , suggesting that activation of microglia may trigger neuronal damage and/or exacerbate initial subtle dysfunctions produced by the virus. (biomedcentral.com)
- The virus has a strong neurotropism and triggers non-purulent meningoencephalitis, associated with anorexia, apathy, somnolence and multiple neuronal dysfunctions. (laboklin.com)
- Neuronal retrograde transport of Borna disease virus occurs in signalling endosomes. (google.fr)
Fatal1
- It has since been recognized as an often-fatal disease affecting a range of livestock and domestic animals (5). (healthmap.org)
White-toothe1
- The virus is maintained in bicolored white-toothed shrews (Crocidura leucodon). (rki.de)
Proventricular2
- Proventricular dilatation disease (PDD) is a globally distributed, serious disease particularly affecting psittacines (large parrots) like macaws, amazons or grey parrots. (laboklin.com)
- Borna virus, which can result in Proventricular Dilatation Disease (PDD), attacks the nerves. (mickaboo.org)
Researchers3
- A few people have tested positive for this virus, and a disproportionate number of those are also clinically depressed, leading researchers to suspect a connection. (chicagotribune.com)
- The virus, named for an 1894 outbreak among horses near Borna, Germany, was described by German researchers as making the horses sad before it destroyed their nervous systems and killed them. (chicagotribune.com)
- Virus expert Hillary Koprowski of Thomas Jefferson University, who has collaborated with the Penn researchers, is skeptical that the depressed people really have the virus. (chicagotribune.com)
Neurotropic virus1
- BDV is a neurotropic virus that causes changes. (nel.edu)
Naturally infected1
- Peripheral and intracerebral T cell immune response in cats naturally infected with Borna disease virus. (maxshouse.com)
Pathogen3
- In addition, the significance of BDV or a BDV-related virus as a human pathogen can now be more directly examined. (sciencemag.org)
- The Borna disease virus (BDV), a potential human pathogen, provides a unique model to study such mechanisms. (pasteur.fr)
- This review highlights the current understanding of the mechanisms of the ER stress activation by Human Hepatitis B virus (HBV), a deadly pathogen affecting more than 350 million people worldwide. (frontiersin.org)
Glycoprotein2
- BDV cell entry follows a receptor-mediated endocytosis pathway, which is initiated by the recognition of an as-yet-unidentified receptor at the cell surface by the virus glycoprotein G. BDV G is synthesized as a precursor (GPC) that is cleaved by the cellular protease furin to produce the mature glycoproteins GP1 and GP2, which have been implicated in receptor recognition and pH-dependent fusion events, respectively. (eurekamag.com)
- Analysis of the glycoprotein gene of Tacaribe virus and neutralization-resistant variants. (springer.com)
Single stranded4
- The Borna disease virus (BDV) is caused by an infectious agent - a negative-sense, single-stranded RNA virus. (psychcentral.com)
- BDV is a single stranded RNA virus that preferentially invades the central nervous system - leading to cognitive changes and encephalopathy (6-7). (healthmap.org)
- viruses possess single-stranded DNA and include such virus families as Parvoviridae and the important bacteriophage M13 . (wikidoc.org)
- viruses possess positive-sense single-stranded RNA genomes. (wikidoc.org)
Occurs3
- Virus spread occurs mainly intraaxonally. (scialert.net)
- It is important that in particular unclear cases of encephalitis in regions where BoDV-1 occurs are investigated for presence of the virus" says Prof. Dr. Martin Beer, head of the Institute of Diagnostic Virology of the FLI. (idw-online.de)
- Borna disease in the horse gives rise to signs like: Unusual posture, gait and ear positions Movement Disturbances (principally ataxia or excess movement) The mode of transmission of BoDV-1/2 is unclear but probably occurs through intranasal exposure to contaminated saliva or nasal secretions. (wikipedia.org)
Variants1
- A negative result does therefore not entirely rule out PDD, as there may be other virus variants, which have not yet been described, leading to this disease. (laboklin.com)
Genes2
- Readers learn about the history of this unique science, how viruses are named, how their genes work, how they copy and package themselves, how they interact with their hosts, how immune systems counteract viruses, and how viruses travel from host to host. (credoreference.com)
- It's possible that BDV creates disease-causing mutations by inserting its genes into the wrong parts of our genomes. (scienceblogs.com)