A species in the genus Bornavirus, family BORNAVIRIDAE, causing a rare and usually fatal encephalitic disease in horses and other domestic animals and possibly deer. Its name derives from the city in Saxony where the condition was first described in 1894, but the disease occurs in Europe, N. Africa, and the Near East.
An encephalomyelitis of horses, sheep and cattle caused by BORNA DISEASE VIRUS.
The most well known avian paramyxovirus in the genus AVULAVIRUS and the cause of a highly infectious pneumoencephalitis in fowl. It is also reported to cause CONJUNCTIVITIS in humans. Transmission is by droplet inhalation or ingestion of contaminated water or food.
Viruses whose taxonomic relationships have not been established.
The type species of APHTHOVIRUS, causing FOOT-AND-MOUTH DISEASE in cloven-hoofed animals. Several different serotypes exist.
Proteins found in any species of virus.
An order comprising four families of eukaryotic viruses possessing linear, non-segmented, negative-strand RNA genomes. The families are BORNAVIRIDAE; FILOVIRIDAE; PARAMYXOVIRIDAE; and RHABDOVIRIDAE.
Ribonucleic acid that makes up the genetic material of viruses.
A species of AVIBIRNAVIRUS causing severe inflammation of the bursa of Fabricius in chickens and other fowl. Transmission is thought to be through contaminated feed or water. Vaccines have been used with varying degrees of success.
Immunoglobulins produced in response to VIRAL ANTIGENS.
A family in the order MONONEGAVIRALES comprising one genus Bornavirus. This family has a unique form of mRNA processing: replication and transcription takes place in the nucleus.
Substances elaborated by viruses that have antigenic activity.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
A genus of the family PICORNAVIRIDAE infecting mainly cloven-hoofed animals. They cause vesicular lesions and upper respiratory tract infections. FOOT AND MOUTH DISEASE VIRUS is the type species.
A genus of the family POXVIRIDAE, subfamily CHORDOPOXVIRINAE, which infect ungulates and may infect humans. ORF VIRUS is the type species.
Proteins conjugated with nucleic acids.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.
Diseases of domestic and wild horses of the species Equus caballus.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
Established cell cultures that have the potential to propagate indefinitely.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Viral proteins that are components of the mature assembled VIRUS PARTICLES. They may include nucleocapsid core proteins (gag proteins), enzymes packaged within the virus particle (pol proteins), and membrane components (env proteins). These do not include the proteins encoded in the VIRAL GENOME that are produced in infected cells but which are not packaged in the mature virus particle,i.e. the so called non-structural proteins (VIRAL NONSTRUCTURAL PROTEINS).
The complete genetic complement contained in a DNA or RNA molecule in a virus.
An acute febrile, contagious, viral disease of birds caused by an AVULAVIRUS called NEWCASTLE DISEASE VIRUS. It is characterized by respiratory and nervous symptoms in fowl and is transmissible to man causing a severe, but transient conjunctivitis.
A species in the genus LAGOVIRUS which causes hemorrhagic disease, including hemorrhagic septicemia, in rabbits.
Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses.
A transmissible viral disease of birds caused by avian herpesvirus 2 (HERPESVIRUS 2, GALLID) and other MARDIVIRUS. There is lymphoid cell infiltration or lymphomatous tumor formation in the peripheral nerves and gonads, but may also involve visceral organs, skin, muscle, and the eye.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The systematic study of the complete complement of proteins (PROTEOME) of organisms.
Electrophoresis in which a second perpendicular electrophoretic transport is performed on the separate components resulting from the first electrophoresis. This technique is usually performed on polyacrylamide gels.
The protein complement of an organism coded for by its genome.
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
The ability to detect chemicals through gustatory receptors in the mouth, including those on the TONGUE; the PALATE; the PHARYNX; and the EPIGLOTTIS.

Reverse transcription-nested polymerase chain reaction for detecting p40 RNA of Borna disease virus, without risk of plasmid contamination. (1/250)

Several methods for the detection of Borna disease virus (BDV) RNA have been reported, one being the reverse transcription-nested polymerase chain reaction (RT-nested PCR) method. However, due to the possibility of contamination of the cloned DNA in a reaction tube, false-positive results might be obtained by RT-nested PCR. To detect only BDV RNA without anxiety of contamination, we developed an RT-nested PCR system using "mRNA selective PCR kit". Using this system, cDNA of BDV p40 in the plasmid (up to 5 x 10(7) molecules) was not amplified. BDV specific sequence was amplified from total RNA (more than 50 pg) of MDCK/BDV cells, which were persistently infected with BDV. These results indicate that this mRNA selective RT-nested PCR system can specifically amplify target RNA as distinguished from plasmid contaminated.  (+info)

A serosurvey of Borna disease virus infection in wild rats by a capture ELISA. (2/250)

For a serological diagnostic test for Borna disease (BD), we developed a capture ELISA with specificity and sensitivity based on detection of antibodies against BD virus (BDV) p40 protein. Using our capture ELISA system, the antibody response of rats inoculated intracerebrally with BDV at 4 weeks after birth showed a sharp increase from 1 to 4 weeks postinoculation (p.i.) and a steady level after 5 weeks p.i. To investigate prevalence of BDV infection among wild rats, we examined sera of Rattus norvegicus in Kami-iso town, Oshima district, Hokkaido, suggesting that rats in this area had not been infected by BDV.  (+info)

Immortalized cell lines derived from mice lacking both type I and type II IFN receptors unify some functions of immature and mature dendritic cells. (3/250)

Cells with dendritic morphology obtained from several organs of mice lacking both type I and II IFN receptors were immortalized by a retrovirus and analysed for their phenotype and for their function to induce cognate immune responses in vitro and in vivo. Two cell lines called AG101 (skin) and AG116 (brain) were cloned and analysed in more detail. They constitutively expressed the cell surface markers CD45, CD11b, MHC class II, F4/80, N418, B7-2 and ICAM1 but were CD8- and B220-negative. Cells from both lines were capable of taking up ovalbumin (OVA). The processed protein was presented to the OVA-specific T cell hybridoma BO97.105 which responded specifically with the production of IL-2. AG101 and AG116 cells were able to induce a mixed lymphocyte reaction as shown by a 50-fold increase of IL-2 production over background. Naive T cells were stimulated by antigen-primed AG101 and AG116, resulting in a T cell proliferation which was 20-30 times over background, and in IL-2 production it was 10 times the background. The capacity of AG101 or AG116 cells to prime naive T cells was directly compared with freshly isolated and cultured cutaneous dendritic cells (DC) from 129 Sv/Ev mice (wtDC). After cognate T cell interaction, IL-6 (20-100-fold) and IL-12 p40 (100-1000-fold) were similarly up-regulated in either AG101, AG116 or mature wtDC. To analyse the capacity of the immortalized DC to induce antibodies in vivo, cell line AG116 was permanently infected with Borna disease virus (BDV) which is unable to replicate in adult mice. One hundred and twenty-nine Sv/Ev mice injected with different cell numbers of AG116 carrying BDV (but not control cells) produced antibodies against the viral BDVp40 and BDVp24 protein. Therefore, the cell lines AG101 and AG116 appear to unify some functions of immature and mature DC. They are able to pick up antigen and process it. In the absence of externally added cytokines, the antigen presented on AG101 or AG116 cells drives T cells with an efficiency similar to mature DC. The cloned cell lines may prove to be useful to study both immune response and replication of infectious agents in the absence of functional interferon receptors.  (+info)

Nuclear localization of the protein from the open reading frame x1 of the Borna disease virus was through interactions with the viral nucleoprotein. (4/250)

Previous studies have predicted the presence of a small open reading frame (ORFx1) located between ORF-1 and ORF-2 of the Borna disease viral (BDV) genome. The ORFx1 is expressed as a p10 protein that is localized in the nucleus and cytoplasm of BDV-infected cells. In this study, we cloned the nucleotide sequence of ORFx1 into expression vectors and showed that it is expressed as p10. An anti-p10 serum gave nuclear and cytoplasmic staining of cells persistently infected with BDV. Immunoprecipitation of p10 from BDV-infected cells coprecipitated the p40 nucleoprotein N and the 24-kDa viral phosphoprotein P. Transient transfection of noninfected cells showed that p10 and p40 can be coprecipitated and revealed that p10 localized in the cytoplasm was imported into the nucleus in the presence of the BDV p40 N. In vitro protein-protein interaction studies on solid phase showed the direct interaction of the p10 with the BDV N protein. The subcellular distribution of p10 and its interaction with p40 suggest that this protein may play a role in the nuclear replication and/or transcription of BDV.  (+info)

Pathogenesis of borna disease virus: granulocyte fractions of psychiatric patients harbor infectious virus in the absence of antiviral antibodies. (5/250)

Borna disease virus (BDV) causes acute and persistent infections in various vertebrates. During recent years, BDV-specific serum antibodies, BDV antigen, and BDV-specific nucleic acid were found in humans suffering from psychiatric disorders. Furthermore, viral antigen was detected in human autopsy brain tissue by immunohistochemical staining. Whether BDV infection can be associated with psychiatric disorders is still a matter of debate; no direct evidence has ever been presented. In the present study we report on (i) the detection of BDV-specific nucleic acid in human granulocyte cell fraction from three different psychiatric patients and (ii) the isolation of infectious BDV from these cells obtained from a patient with multiple psychiatric disorders. In leukocyte preparations other than granulocytes, either no BDV RNA was detected or positive PCR results were obtained only if there was at least 20% contamination with granulocytes. Parts of the antigenome of the isolated virus were sequenced, demonstrating the close relationship to the prototype BDV strains (He/80 and strain V) as well as to other human virus sequences. Our data provide strong evidence that cells in the granulocyte fraction represent the major if not the sole cell type harboring BDV-specific nucleic acid in human blood and contain infectious virus. In contrast to most other reports of putative human isolates, where sequences are virtually identical to those of the established laboratory strains, this isolate shows divergence in the region previously defined as variable in BDV from naturally infected animals.  (+info)

Inhibition of Borna disease virus replication by ribavirin. (6/250)

The guanosine analogue ribavirin was tested for antiviral activity in two neural cell lines, human oligodendrocytes and rat glia, against Borna disease virus (BDV) strains V and He/80. Ribavirin treatment resulted in lower levels of virus and viral transcripts within 12 h. Addition of guanosine but not adenosine resulted in a profound reduction of the ribavirin effect. Ribavirin appears to be an effective antiviral agent for treatment of BDV infection in vitro. A likely mechanism for its activity is reduction of the intracellular GTP pool, resulting in inhibition of transcription and capping of BDV mRNAs.  (+info)

T cell ignorance in mice to Borna disease virus can be overcome by peripheral expression of the viral nucleoprotein. (7/250)

Infection of neonates with Borna disease virus (BDV) induces severe meningoencephalitis and neurological disorder in wild-type but not in beta(2)-microglobulin-deficient mice of strain MRL (H-2(k)). Temporary in vivo depletion of CD8(+) T cells delayed BDV-induced disease for several weeks. Depletion of CD4(+) T cells had a similar beneficial effect, indicating that the BDV-induced neurological disorder in mice is a CD4(+) T cell-dependent immunopathological process that is mediated by CD8(+) T cells. Lymphocytes prepared from brains of diseased mice were mainly from the CD8(+) T cell subset. They showed up-regulation of activation markers and exerted strong MHC I-restricted cytotoxic activity against target cells expressing the BDV nucleoprotein p40. Infection of B10.BR (H-2(k)) or congenic C57BL/10 (H-2(b)) mice resulted in symptomless, lifelong persistence of BDV in the brain. Superinfection with a recombinant vaccinia virus expressing BDV p40 but not with other vaccinia viruses induced severe neurological disease and encephalitis in persistently infected B10.BR mice but not in persistently infected C57BL/10 mice, indicating that the disease-inducing T cell response is restricted to the nucleoprotein of BDV in H-2(k) mice. Our results demonstrate that the cellular arm of the immune system may ignore the presence of a replicating virus in the central nervous system until proper antigenic stimulation at a peripheral site triggers the antiviral response.  (+info)

Enhancement of Borna disease virus transcription in persistently infected cells by serum starvation. (8/250)

Transcription of Borna disease virus (BDV) in persistently infected MDCK (MDCK/BDV) cells increased in the fetal bovine serum free media as detected by Northern blot analysis. Especially, the amount of 1.9-kb RNA without cap formation at the 5' end and polyadenylation at the 3' end, increased as compared to other mRNA molecules of BDV. Growth arrest of MDCK/BDV cells observed in the condition of serum starvation might be important for increasing viral transcription. Since N-cadherin is the responsible factor for cell-to-cell contact, MDCK/BDV cells were cultured in calcium free medium which inhibits the interaction of N-cadherin. However, inhibition of cell-to-cell contact by N-cadherin is not effective on up regulation of viral transcription. Our finding in this study indicates that enhancement of BDV transcription by serum starvation is a useful technique for further investigation in understanding of mechanisms of BDV transcription.  (+info)

Characterization of the Borna disease virus phosphoprotein, p23.: Borna disease virus infection is diagnosed by the presence of serum antibodies reactive with t
TY - JOUR. T1 - Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection. AU - Bautista, Jan R.. AU - Schwartz, Gary J.. AU - De La Torre, Juan Carlos. AU - Moran, Timothy H. AU - Carbone, Kathryn M.. PY - 1994. Y1 - 1994. N2 - Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), with no signs of encephalitis or Borna disease. We measured body weight, body length, taste preferences, and spontaneous locomotor activity over a 4-month period in PTI-NB and control rats. PTI-NB rats had decreased weight and length but not detectable disturbances in growth hormone and insulin-like growth factor-1 biosynthesis as compared to control rats. In single bottle taste acceptance tests, PTI-NB rats did not differ from controls and drank normal amounts of all solutions. When offered a choice of solutions in two-bottle taste preference tests, PTI-NB rats exhibited a normal preference for saccharin and a ...
Detection and sequence analysis of borna disease virus p24 RNA from peripheral blood mononuclear cells of patients with mood disorders or schizophrenia and of b
Borna disease virus (BDV) is a non-segmented, negative-strand RNA virus that replicates and transcribes its genome in the nucleus of infected cells. It uses the cellular splicing machinery to generate a set of alternatively spliced mRNAs from the 2.8 and 7.1 kb primary transcripts, each harbouring two introns. To determine whether splicing of these transcripts is regulated by viral factors, the extent of splicing was studied in infected cells and COS-7 cells transiently transfected with plasmids encoding the 2.8 kb RNA of BDV. Unspliced RNA was found to be the most abundant RNA species in infected cells, whereas viral transcripts lacking both introns were only found in minute amounts. In sharp contrast, plasmid-derived 2.8 kb RNA was predominantly intron 1-spliced and double-spliced. Co-expression of the BDV proteins P, N and X did not influence splicing of plasmid-expressed 2.8 kb RNA. Furthermore, the splicing pattern did not change when the 2.8 kb RNA was expressed in BDV-infected cells. Based on
Borna disease virus, a newly classified nonsegmented negative-strand RNA virus with international distribution, infects a broad range of warm-blooded animals from birds to primates. Infection causes movement and behavioral disturbances reminiscent of some neuropsychiatric syndromes. The virus has not been clearly linked to any human disease; however, an association between infection with the virus and selected neuropsychiatric disorders has been suggested. We reviewed recent advances in Borna disease virus research, focusing on evidence of infection in humans ...
Borna disease virus (BDV) is the causative agent of a neurological disorder in mammals and ostriches called Borna disease. BDV is also of interest as infective agent in humans with psychiatric diseases, such as mood disorders and schizophrenia, as well as in experimental models of these diseases. In Sweden, the progressive and mostly fatal neurological disorder among domestic cats, known as staggering disease or feline Borna disease, is caused by BDV. Except for cats, natural BDV infection has also been described in horses and a free-ranging lynx in Sweden. Major clinical signs of staggering disease are staggering movement, alteration in behaviour, lumbosacral pain and inability to retract the claws. Today staggering disease is clinically suspected by excluding other reasons for clinical signs and the diagnosis is further established by examining the central nervous system histopathologically at autopsy. The diagnosis is finally confirmed by immunohistochemistry. In order to get a better ...
Read Neuron-glia interactions in the rat retina infected by Borna disease virus, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Borna disease virus-1 (BoDV-1) was recently discovered as cause of severe and often fatal encephalitis in humans. BoDV-1 is known to cause neurological disease in horses and sheep mainly in South and Central Germany. The virus is maintained in bicolored white-toothed shrews (Crocidura leucodon). The incidence of infection and risk factors in humans are completely unresolved. Veterinarians may be disproportionally BoDV-1-exposed through contact to animals not recognized to be BoDV-1 infected. We conducted three serosurveys predominantly in endemic areas of South Germany for the presence of BoDV-1-reactive antibodies. Anonymized residual samples from two serosurveys of veterinarians (n = 736) with interview data on exposures and one serosurvey among blood donors (n = 373) were screened with an indirect immunofluorescence antibody test, followed by a newly developed immunoblot as confirmatory assay. One serum from a 55-59-year-old veterinarian who worked in an animal practice and as a meat ...
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): This article cites 58 articles, 23 of which can be accessed free
Summary The effect of interferon (IFN) on infection and maintenance of persistent infection of Borna disease (BD) virus in cell cultures was investigated. Acutely BD virus-infected primary rabbit brain and rat lung cells produced significant levels of interferon detectable 3 days post-infection in the culture supernatants. Rat brain and rat lung cells persistently infected with BD virus produced only moderate levels of IFN over a long period. In contrast, persistently infected Madin-Darby canine kidney (MDCK) cells did not produce detectable amounts of IFN. Exogenous homologous IFN completely inhibited the expression of BD virus antigen in acutely infected rabbit brain cells, when added during the first 24 h after infection. IFN added later (2 to 6 days post-infection) reduced virus titres to different degrees depending on the onset of treatment. However, IFN added to persistently infected rat lung cells did not appear to influence the degree or quality of BD virus antigen expression or the
Numerous species of mammals are susceptible to this virus. It is of clinical relevance particularly in horses, in cats (where the disease is also called staggering disease) and in sheep. The virus has a strong neurotropism and triggers non-purulent meningoencephalitis, associated with anorexia, apathy, somnolence and multiple neuronal dysfunctions. Animals suffering from Borna disease develop motor and behavioural disorders. In horses and sheep, in addition to the symptoms listed above, a lowered head posture, separation from the herd, empty chewing and salivation have been described and, at a later stage, recumbency and flailing movements. Cats frequently suffer from hind-leg ataxia and lumbosacral pain.. There is often little or no immune response, which makes it difficult to diagnose by testing for antibodies. The incubation period is unknown. The progression of a clinically manifested infection is lethal (duration of the disease usually 1 - 3 weeks).. Clinically inapparent infections are ...
Previous studies have shown that schizophrenics and those with mood disorders have higher levels of Borna Disease Virus (BDV) RNA and anti-BDV antibodies. The researchers in this study aimed to determine the relationship between infection with Borna Disease Virus (BDV) and schizophrenia and other mood disorders, with respect to symptom subtypes and clinical time course. 32 schizophrenics and 33 mood disorder patients were tested against 25 controls. Serum was collected from the patients, and Western Blots were used to detect anti-BDV-p10 (nucleoprotein fusion proteins) antibodies. The study found a statistically significant correlation with the levels of anti-BDV antibodies and the mood disorder patients, but the study found no significant correlations in the case with schizophrenia. A significant relationship was found, however, between BDV antibody levels and the type of schizophrenia (productive or positive, against deficit or negative). The study also found a similar relationship between ...
Borna disease virus replication in organotypic hippocampal slice cultures from rats results in selective damage of dentate granule cells. J Virol 79: 11716-23. (#: these authors were co-senior authors) H. Brinks, S. Conrad, J. Vogt, J. Oldekamp, A. Sierra, L. Deitinghoff, I. Bechmann, G. Alvarez-Bolado, B. Heimrich#, P.P. Monnier#, B.K. Müller#, and T. Skutella# (2004 ...
Borna disease virus replication in organotypic hippocampal slice cultures from rats results in selective damage of dentate granule cells. J Virol 79: 11716-23. (#: these authors were co-senior authors) J. Schwenk, N. Harmel, G. Zolles, W. Bildl, A. Kulik, B. Heimrich, O. Chisaka, P. Jonas, U. Schulte, B. Fakler, N. Klöcker (2009 ...
The disease in horses is endemic in some regions of Germany and Switzerland. In recent years infections have been reported in cattle, sheep, goats, monkeys, ostriches, cats and humans. Serological evidence from humans indicate that the virus is probably widespread in Europe and North America.. Humans are infected by Borna disease virus and show an antibody response but not clinical disease. Whether or not these infections can be responsible for some psychiatric disorders is currently under investigation. Some serological evidence suggests they may be.. Questions that need to be answered are: What is the prevalence rate in humans? What is the source or sources of human infections? Is there a natural reservoir? Can humans transmit the disease in the way horses do? ...
Borna disease virus (BDV) The only species in the genus Bornavirus. Named after a town in Saxony where the first major outbreak in horses occurred. Negative-strand RNA virus which produces persistent infection in a variety of experimental …. The London encyclopaedia, or, Universal dictionary of science, art, literature, and practical mechanics, by the orig. ed. of the Encyclopaedia metropolitana [T. Curtis]. (1839). by Thomas Curtis (of Grove house sch, Islington ...
Borna disease virus (BDV) The only species in the genus Bornavirus. Named after a town in Saxony where the first major outbreak in horses occurred. Negative-strand RNA virus which produces persistent infection in a variety of experimental …. The London encyclopaedia, or, Universal dictionary of science, art, literature, and practical mechanics, by the orig. ed. of the Encyclopaedia metropolitana [T. Curtis]. (1839). by Thomas Curtis (of Grove house sch, Islington ...
Perez, M., Clemente, R., Robison, C. S., Jeetendra, E., Jayakar, H. R., Whitt, M. A., de la Torre, J. C. Generation and characterization of a recombinant vesicular stomatitis virus expressing the glycoprotein of Borna disease virus Journal of Virology 2007 81:5527-5536 DOI:10.1128/jvi.02586-06 PMID:17376911 ...
Borna disease virus 1 (BoDV-1) has been associated with human disease in four cases in Germany resulting in the death of three people. As three of the cases belong to a cluster of solid organ recipients from a single donor, donor-derived BoDV-1 transmission is possible. There is no evidence that the donor had any clinical manifestation of the disease. ...
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Nonsegmented negative-strand (NNS) RNA viruses initiate infection by delivering into the host cell an extremely specific RNA synthesis machine comprising the genomic RNA completely encapsidated from the viral nucleocapsid protein and from the viral polymerase. cap-forming actions. The capping enzyme maps to a globular site, which can be juxtaposed towards the band, as well as the cap methyltransferase maps to a far more distal and connected globule flexibly. Upon P binding, L goes through a substantial rearrangement that may reveal an optimal placing of its practical domains for transcription. The structural map of L provides fresh insights in to the interrelationship of its different domains, and their rearrangement on P binding thats likely very important to RNA synthesis. As the set up of conserved areas involved with catalysis can be homologous, the structural insights acquired for VSV L most likely extend to all or any NNS RNA infections. rows in Fig. 4with averages 8C10 in Fig. 1row in ...
Yamaguchi, Kazunari et al Detection of Borna Disease Virus-Reactive Antibodies from Patients with Psychiatric Disorders and from Horses by Electrochemiluminescence Immunoassay. Clinical and Diagnostic Laboratory Immunology 6.5 (1999): 696-700. Web. 15 Aug. 2020. ...
This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 25-31 March 2018 and includes updates on dengue, chikungunya, measles, listeria, Borna diseases and gonorrhoeae. ...
The Tap-tagged PA and its interacting proteins ended up co-purified with immunoglobinlin G-Sepharose (GE Health care) and washed with binding buffer . The
Bornaviridae is a family of viruses in the order Mononegavirales. Horses, sheep, cattle, rodents, birds, reptiles, and humans serve as natural hosts. Currently, 16 viruses are assigned to eight species included in one genus in this family. Diseases associated with bornaviruses include Borna disease, a fatal neurologic disease of mammals restricted to central Europe; and proventricular dilatation disease in birds. Borna disease was first identified in 1926 and its genome was isolated in 1990. The viral family is named after the city of Borna in Saxony, Germany, which is where a large number of animals were lost to the sporadic encephalopathy caused by the viral disease. Table legend: * denotes type species. Bornavirions are enveloped, with spherical geometries. The diameter is around 70 to 130 nm. Genomes are linear, around 8.9kb in length. The genome codes for 9 proteins. Below are a few of the essential proteins of Bornaviridae that have been characterized. Viral replication is nuclear. Entry ...
Borna Disease Virus (BDV) is single stranded RNA virus, which may infect a wide range of animal species. Manifestations of the experimental BDV infection show some resemblance to psychopathological symptoms of mental disorders in humans. Several reports suggest the higher prevalence of anti-BDV antibodies in psychiatric patients than in healthy controls. However, the seroprevalence of anti-BDV antibodies varied due to the different serological methods used in the previous studies. Electrochemiluminescence Immunoassay (ECLIA) is a recently developed, highly specific method of detecting antibodiess directed toward two BDV proteins: p24 and p40. We used the ECLIA method for the assessment of seropositivity in 946 psychiatric patients hospitalized in the psychiatric hospitals in the western part of Poland. All patients were clinically diagnosed with ICD-10 criteria. Anti-p40 antibodies have not been found in the studied sample. We found anti p-24 antibodies in 23 cases, which give the seroprevalence ...
The order Mononegavirales is the taxonomic home of numerous related viruses. Members of the order that are commonly known are, for instance, Ebola virus, human respiratory syncytial virus, measles virus, mumps virus, Nipah virus, and rabies virus. All of these viruses cause significant disease in humans. Many very important pathogens of nonhuman animals and plants are also members of this order. The order Mononegavirales is a virological taxon that was created in 1991 and emended in 1995, 1997, 2000, 2005, 2011, 2016, and 2017. The name Mononegavirales is derived from the Greek adjective μóνος [monos] (alluding to the monopartite and single-stranded genomes of most mononegaviruses), the Latin verb negare (alluding to the negative polarity of these genomes), and the taxonomic suffix -virales (denoting a viral order). The order currently includes the eight virus families Bornaviridae, Mymonaviridae, Filoviridae, Nyamiviridae, Paramyxoviridae, Pneumoviridae, Rhabdoviridae, and Sunviridae. ...
The bicoloured shrew (Crocidura leucodon) lives exclusively in Central Europe, the region where the Borna disease occurs. This area is mostly within Germany, but also includes the eastern part of Switzerland and Vorarlberg in western Austria. Virologist Nowotny explains: The distribution of bicoloured shrews remains fairly constant because the animals stay within their habitats. They do not like to move around. In fact, the number of incidents of Borna disease has actually declined in the last few years. There are currently about 100 cases per year.. Genetics reveals transmission mechanism. A genetic analysis of viruses taken from bicoloured shrews and horses provides further proof that the bicoloured shrew acts as a pathogen reservoir. The viral strains found in the shrews correspond exactly with the strains from sick horses in the same region. This supports the assumption that the virus sub-types develop in a particular region over the course of centuries in bicoloured shrews and do not ...
TY - JOUR. T1 - Taxonomy of the order Mononegavirales. T2 - update 2016. AU - Afonso, Claudio L.. AU - Amarasinghe, Gaya K.. AU - Bányai, Krisztián. AU - Bào, Yīmíng. AU - Basler, Christopher F.. AU - Bavari, Sina. AU - Bejerman, Nicolás. AU - Blasdell, Kim R.. AU - Briand, François Xavier. AU - Briese, Thomas. AU - Bukreyev, Alexander. AU - Calisher, Charles H.. AU - Chandran, Kartik. AU - Chéng, Jiāsēn. AU - Clawson, Anna N.. AU - Collins, Peter L.. AU - Dietzgen, Ralf G.. AU - Dolnik, Olga. AU - Domier, Leslie L.. AU - Dürrwald, Ralf. AU - Dye, John M.. AU - Easton, Andrew J.. AU - Ebihara, Hideki. AU - Farkas, Szilvia L.. AU - Freitas-Astúa, Juliana. AU - Formenty, Pierre. AU - Fouchier, Ron A.M.. AU - Fù, Yànpíng. AU - Ghedin, Elodie. AU - Goodin, Michael M.. AU - Hewson, Roger. AU - Horie, Masayuki. AU - Hyndman, Timothy H.. AU - Jiāng, Dàohóng. AU - Kitajima, Elliot W.. AU - Kobinger, Gary P.. AU - Kondo, Hideki. AU - Kurath, Gael. AU - Lamb, Robert A.. AU - Lenardon, ...
Borna lightly sweetened premium pistachio drink is one half the newest product range launched by borna foods. With a primary focus on pistachios, borna foods have continued to push boundaries in the pistachio world, by creating the UKs first pistachio-based milk alternative. This drink is a dairy free product, which contains a short ingredients list of pistachios (4%), water and sea salt, with a hint of sugar to give that subtle sweet taste. The range has been created using the highest quality pistachios which borna personally source from certified farms around the globe. As pistachios are naturally high in fibre, and the drink contains added calcium and vitamin b12, it means that this drink is jam-packed with health benefits. 500ml. Item Details: As well as this, the drink is also packed with protein which is essential for building and repairing tissue. This gluten free drink is 100% natural as it does not contain any preservatives or artificial flavours, and all ingredients are derived from ...
Two positive virus tests at Djokovic event: Croatias Borna Coric along with Grigor Dimitrov have both tested.. News video on newsR on Monday, 22 June 2020
The analysis of data collected in connection with the investigation of a number of problems in immunity has led to a series of results, in part already published, bearing upon the blood and circulation. The conclusion was reached that in certain cases a precise and definite relationship to the body surface exists in warm-blooded animals in accordance with the formula Wn/a = k, where W is the body weight of the animal, a represents the mass of the body fluid, tissue, or organ under investigation, k is a constant, and the value of n is approximately 0·70-0·72. In view of the fact that the carriage of oxygen is one of the chief functions of the circulation, and that the volume of the blood (1), (2), and the aortic area (3), (4), (area of cross-section of aorta), have been shown by us to be proportional to the body surface in warm-blooded animals, while, as we have also found, the total oxygen capacity is the main factor in determining the size of the heart (5), it appeared to be of interest to ...
Serological incidence of Gumboro disease virus infection in chicken flocks in Cairo district. , Amer, M. M.,.Bastami M. A., D.G.khilfa, and Hamouda A. S. , Assut. Vet. Med. J., , Volume 17, Issue 33, p. 211-216., (1986 ...
Vivaldi Biosciences was developing small molecule antiviral drugs for the treatment of respiratory diseases caused by negative-strand RNA viruses, including
Although interferon-gamma (IFN-) has a critical function in the noncytolytic elimination of several neurotropic viral infections, the signaling response to the cytokine is not characterized in primary... Read More ...
Summary of Facts and Submissions. I. European patent No. 0 846 181 with the title cDNA corresponding to the antigenome of nonsegmented negative strand RNA viruses, and process for the production of such viruses encoding additional antigenically active proteins was granted on European patent application No. 96928446.2 (published as WO 97/06270). The patent was granted with 21 claims.. II. Claim 1 of the patent as granted read as follows:. 1. A method for the production of an infectious non-segmented negative-strand RNA virus of the family Paramyxoviridae comprising. (a) introducing a cDNA molecule contained in a plasmid, wherein said cDNA molecule comprises the entire (+)-strand sequence of said negative- strand RNA virus operatively linked to an expression control sequence, which allows the synthesis of anti-genomic RNA transcripts bearing the authentic 3 -termini, and wherein said cDNA molecule consists of an integral multiple of six nucleotides, into a helper cell expressing an ...
Infections with viruses of the order MONONEGAVIRALES. The concept includes FILOVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; and RHABDOVIRIDAE INFECTIONS.
Researchers at The Pirbright Institute have shown that when drugs are used to inhibit the cellular protein, hsp90, foot-and-mouth disease virus (FMDV) production is reduced. Hsp90 is a protein used by cells to fold other proteins correctly and it was shown to be required by FMDV to form the outer shell of the virus which protects the viral genome. This provides new insights
Summary The production, purification and properties of the A antigen induced by Marek's disease virus in tissue culture were investigated. It was found that although virus multiplied on passage in chick kidney, chick embryo and duck embryo cells the antigen was produced only in chick kidney and duck embryo cultures. The results suggested that the A antigen produced by duck embryo cells was a glycoprotein having a mol. wt. in the range 70 000 to 90 000 and was heterogeneous in charge (pI 4.5 to 5.5). A 20-fold purification was achieved by electrophoresis in 5% acrylamide gel with a recovery of 45%. An equally good purification was also possible by chromatography on DEAE-Sephadex A50 and Sephadex G200, although the recovery was only 20% in this case.
Matijašić, Mario and Meštrović, Tomislav and Perić, Mihaela and Čipčić Paljetak, Hana and Panek, Marina and Vranešić Bender, Darija and Ljubas Kelečić, Dina and Krznarić, Željko and Verbanac, Donatella (2016) Modulating composition and metabolic activity of the gut microbiota in IBD patients. International Journal of Molecular Sciences, 17 (4). p. 578. ISSN 1422-0067 Benković, Vanesa and Kolčić, Ivana and Ivičević Uhernik, Ana and Vranešić Bender, Darija and Oreb, Ida and Stevanović, Ranko and Krznarić, Željko (2014) The economic burden of disease-related undernutrition in selected chronic diseases. Clinical Nutrition, 33 (4). pp. 689-93. ISSN 0261-5614 Zelić, Marko and Vranešić Bender, Darija and Ljubas Kelečić, Dina and Župan, Željko and Cicvarić, Tedi and Maldini, Branka and Durut, Iva and Rahelić, Velimir and Škegro, Mate and Majerović, Mate and Perko, Zdravko and Šustić, Alan and Madžar, Tomislav and Kovačić, Borna and Kekez, Tihomir and Krznarić, ...
Introduction: The SARS-COV-2 is a non-segmented positive-sense RNA virus that belongs to the genus Beta Coronavirus. The envelope-anchored trimeric spike protein on the virus surface is considered to be the key protein for ...
Toxoplasma gondii (T. gondii) is a ubiquitous parasite of warmblooded animals that causes one of the most common parasitic infections in humans. Althoug..
In this mammalian biology science fair project, students will determine how much huddling reduces heat loss in warm-blooded animals.
The order Mononegavirales is the taxonomic home of numerous related viruses. Members of the order that are commonly known are, for instance, Ebola virus, human respiratory syncytial virus, measles virus, mumps virus, Nipah virus, and rabies virus. All of these viruses cause significant disease in humans. Many very important pathogens of nonhuman animals and plants are also members of this order. ...
Mononegavirales adalah ordo virus RNA yang berada dalam filum Negarnaviricota dan kelas Monjiviricetes.[1] Nama Mononegavirales berasa dari bahasa Yunani μóνος [monos] yang merujuk pada genom untai tunggal pada sebagian besar ordo ini, bahasa Latin negare yang merujuk pada sifat sense-negatif genom virus, serta akhiran -virales yang menunjukkan ordo virus.[2] Anggota ordo ini yang dikenal di antaranya virus rabies dan virus Ebola yang dapat menyebabkan penyakit, baik pada manusia maupun hewan. ...
Foot-and-mouth disease virus (FMDV) is a single stranded RNA virus in the picornavirus family. It is the causative agent of foot-and-mouth disease, globally the most important a�iction of cloven hoofed animals. The FMDV genome has several features that are not found amongst other viruses within the Picornaviridae. These include a large 50 untranslated region (UTR), almost twice the length of that found in enteroviruses, containing highly structured RNA elements unique to FMDV, such as the S-fragment and several tandemly repeated pseudoknots. Unique aspects are also found within the coding region, where FMDV is the only picornavirus reported to contain multiple copies of the 3B gene. The reasons behind possession of these unusual deviations from the dogma of the picornaviral genome is so far unknown and therefore poses an attractive target for further research. The S-fragment is a predicted 360 nucleotide stem-loop at the 50 end of the FMDV genome. The better studied poliovirus (PV) has a well ...
The hematological lesions consequent upon velogenic Newcastle disease virus (NDV) infection were investigated in 6-week-old ducks and chickens. Following intramuscular inoculation, the results indicated significantly lower (p
Quit with Us: A s ocial m arketing intervention to motivate and assist individuals to stop smoking using Tenovus retail outlets. Maura Matthews and Dr Sioned Pearce UK National Smoking Cessation Conference 13 th June 2014. Who are we and what do we do?. Slideshow 2694819 by borna
Researchers from the University of Pittsburgh and Stanford University have discovered that a supposedly inactive protein actually plays a crucial role in the ability of one the worlds most prolific pathogens to cause disease, findings that suggest the possible role of similar proteins in other diseases. The team reported online on March 21, 2011, in PNAS that Toxoplasma gondii-the parasitic protozoan responsible for toxoplasmosis-attacks healthy cells by first injecting them with pseudokinases, which are enzymes that have abandoned their original function of transferring phosphates. When the researchers engineered strains of T. gondii without a particular pseudokinase gene cluster called ROP5, the pathogen was subsequently unable to cause disease in mice-a notable loss of potency in an organism that can infect nearly any warm-blooded animal. These results are among the first to implicate pseudokinases as indispensible actors in pathogen-based disease, said senior author Dr. Jon Boyle, a ...
Anyway, my room was close enough that I could have smelled large warm-blooded animals and leather as soon as I stepped out the door. If I didnt have a cold, that is. And if those hybrid beasts of burden had actually been there, of course. I was the only living creature in the area. As usual when that happens, I began to wonder if I was in the wrong place. Id checked it out the afternoon before, read all the signs and such, so I was pretty sure this was the appointed hour and the anointed (theres a sly bathroom joke in there, if you know equines) place ...
Lipkin, W. I; Hornig, M; Briese, T (2001). "Borna disease virus and neuropsychiatric disease--a reappraisal". Trends in ... "Does Borna Disease Virus Cause Mental Health? Stephanie Berger. Columbia University Mailman School of Public Health. January 31 ... Bode, L; Ludwig, H (2003). "Borna Disease Virus Infection, a Human Mental-Health Risk". Clinical Microbiology Reviews. 16 (3): ... "Borna disease is a neurotropic negative-strand RNA virus that infects a wide range of vertebrate hosts," causing "an immune- ...
... white-toothed shrew is a natural reservoir species for the Borna disease virus which is the causative agent of Borna disease, a ... "Shrews as Reservoir Hosts of Borna Disease Virus". Emerging Infectious Diseases. 12 (4): 675-677. doi:10.3201/eid1204.051418. ... Kamhieh S, Flower RL (June 2006). "Borna disease virus (BDV) infection in cats. A concise review based on current knowledge". ... Rott, R.; Herzog, S.; Bechter, K.; Frese, K. (1991). "Borna disease, a possible hazard for man?". Archives of Virology. 118 (3- ...
"Borna Disease Virus Infection in Animals and Humans". Emerging Infectious Diseases. 3 (3): 343-352. doi:10.3201/eid0303.970311 ... Diseases associated with bornaviruses include Borna disease, a fatal neurologic disease of mammals restricted to central Europe ... Richt, JA; Rott, R (2001). "Borna disease virus: a mystery as an emerging zoonotic pathogen". Vet J. 161 (1): 24-40. doi: ... Borna disease was first identified in 1926 and its genome was isolated in 1990. In 1996, ICTV proposed the creation of the ...
A study investigating the effects of the Borna disease virus on treeshrews has given new insight into neurological disease. ... Sprankel, H., Richarz, K., Ludwig, H. and Rott, R. (1978). Behavior Alterations in Tree Shrews Induced by Borna Disease Virus. ... Their susceptibility to viruses has also piqued interest in using them to study immune responses to infections such as ... Recent studies have used treeshrews to study infectious, metabolic, neurological, and psychiatric diseases, as well as cancers ...
In general these viruses show only about 65% sequence identity with mammalian Borna disease virus 1 (BoDV-1). The overall ... "Novel Borna Virus in Psittacine Birds with Proventricular Dilatation Disease". Emerging Infectious Diseases. 14 (12): 1883-1886 ... Avian bornaviruses have been reported, yet not proven, as the cause of proventricular dilatation disease (PDD), a disease of ... "Use of Avian Bornavirus Isolates to Induce Proventricular Dilatation Disease in Conures". Emerging Infectious Diseases. 16 (3 ...
"Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells". Antiviral Res. 87 (2): 249- ... Jangra RK, Yi M, Lemon SM (2010). "Regulation of hepatitis C virus translation and infectious virus production by the microRNA ... other RNA viruses and viral mimetics (e.g. poly(I:C)). Recent studies have shown that replication of hepatitis C virus (HCV) is ... Biomarkers in Liver Disease. V. B. Patel and V. R. Preedy. Dordrecht, Springer Netherlands: ISBN 978-94-007-7675-3, page 193- ...
Pletnikov, M. V.; Moran, T. H.; Carbone, K. M. (2002). "Borna disease virus infection of the neonatal rat: Developmental brain ... Much research has been done into the use of a rat model to show how Borna virus infection, exposure to valproic acid in utero, ... Centers for Disease Control (2008-02-08). "Mercury and vaccines (thimerosal)". Retrieved 2011-08-01. Crawley, J. N. (2012). " ... Klauck, S. M.; Poustka, A. (2006). "Animal models of autism". Drug Discovery Today: Disease Models. 3 (4): 313-318. doi:10.1016 ...
Nöske K, Bilzer T, Planz O, Stitz L (1998). "Virus-Specific CD4+ T Cells Eliminate Borna Disease Virus from the Brain via ...
... where she studied the virus associated with Borna disease. She joined the faculty of Colorado State University in 1990 and ... VandeWoude studies viruses including Feline Immunodeficiency Virus, Feline Leukemia Virus, and Feline Foamy Virus that infect ... Susan (Sue) VandeWoude is a veterinarian and researcher in the United States, specializing in viral diseases of cats. She is ...
Polio, measles, varicella-zoster, rubella, herpes simplex virus type 2, maternal genital infections, Borna disease virus, and ... It is a pathogenic theory of disease in which it is thought that a proximal cause of certain cases of schizophrenia is the ... An updated meta-analysis on CNVs for schizophrenia published in 2015 expanded the number of CNVs indicated in the disease, ... 2010-10-26). "Disease-relevant autoantibodies in first episode schizophrenia". Journal of Neurology. 258 (4): 686-688. doi: ...
She directs the clinical core of an international investigation of the role of Borna disease virus in human mental illness and ... based on neonatal rat infection with Borna disease virus. In 2004, Hornig published a controversial paper concluding that, in a ... In the 1990s, Hornig investigated the potential link between the Borna virus and depression in humans. Hornig has been ... In 2008, she published a study concluding that there was no association between presence of measles vaccine virus in the gut of ...
Laboratory rats infected with Borna disease virus show some symptoms similar to those of autism but blood studies of autistic ... Viruses have long been suspected as triggers for immune-mediated diseases such as multiple sclerosis but showing a direct role ... or whether they are secondary to the disease processes. As autoantibodies are found in diseases other than ASD, and are not ... Clinical Infectious Diseases. 2009;48(4):456-461. doi:10.1086/596476. PMID 19128068. Paul R. Parents ask: am I risking autism ...
Bode, L; Ludwig, H (2003). "Borna disease virus infection, a human mental-health risk". Clinical Microbiology Reviews. 16 (3): ... JC Virus and Simian Virus 40 Infection in Humans, and Association with Human Tumors". Polyomaviruses and Human Diseases. ... June 2010). "Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine". Cell ... Takahashi, M; Yamada, T (1999). "Viral etiology for Parkinson's disease--a possible role of influenza A virus infection". ...
Borna Disease Virus, das Virus der Bornaschen Krankheit, mit Species Mammalian 1 orthobornavirus (Typus) u. a. ... Usutu-Virus - en. Usutu virus (USUV), Zika-Virus - en. Zika virus (ZIKV), sowie Gelbfieber-Virus - en. Yellow fever virus (YFV) ... Genus ‚Negevirus', mit Species ‚Blackford virus', ‚Bofa virus', ‚Buckhurst virus', ‚Marsac virus', sowie ‚Muthill virus'[53] ... Sorghum mosaic virus (SrMV), Lily-Mottle-Virus - en. Lily mottle virus (LMoV), sowie Sellerie-Virus Y - en. Apium virus Y (ApVY ...
... a family of viruses associated with Borna disease Borna disease virus Borna language (Democratic Republic of the Congo), a ... Borna may refer to: Borna, Leipzig, a town in Saxony, Germany Borna, a subdivision of Bahretal municipality, Saxony, German ... a Croatian masculine given name Bertin Borna (1930-2007), a Beninese politician Borna disease, an infectious neurological ... Borna Dam, an earthfill dam on Borna river near Ambejogai, Beed district, Maharashtra, India Borna (duke), the Duke of Dalmatia ...
Novel borna virus in psittacine birds with proventricular dilatation disease. Emerging infectious diseases 14(12), 1883-6.e ... Kristen Bole (2008-07-29). "UCSF researchers identify virus behind mysterious parrot disease". UCSF News Office. Archived from ... Proventricular dilatation disease (PDD) is an incurable probably viral disease of psittacine birds. It was first recognized and ... The virus can also affect the Purkinje cells of the heart, the adrenal medulla, the brain, and the spinal cord. On necropsy the ...
Although Borna disease viruses 1 and 2 are mainly seen as the causative agent of Borna disease in horses and other animals, ... Borna disease viruses 1 and 2 are neurotropic viruses and members of the Bornaviridae family within the Mononegavirales order. ... Borna disease, also known as sad horse disease, is an infectious neurological syndrome of warm-blooded animals, caused by Borna ... The virus name is derived from the town of Borna in Saxony, Germany, which suffered an epidemic of the disease in horses in ...
The ancestral virus seems likely to have been a high AT content virus. Borna disease was first described in 1885 as "heated ... The Borna disease viruses 1 and 2 (BoDV-1 and BoDV-2) are members of the species Mammalian 1 orthobornavirus and cause Borna ... "N-terminal domain of Borna disease virus G (p56) protein is sufficient for virus receptor recognition and cell entry". Journal ... Wolff T, Pfleger R, Wehner T, Reinhardt J, Richt JA (April 2000). "A short leucine-rich sequence in the Borna disease virus p10 ...
Thogoto and Borna disease viruses". Virus Res. 95 (1-2): 3-12. doi:10.1016/S0168-1702(03)00159-X. PMID 12921991.. ... Influenza virus A Influenza A virus* H1N1, H1N2, H2N2, H3N1, H3N2, H3N8, H5N1, H5N2, H5N3, H5N8, H5N9, H7N1, H7N2, H7N3, H7N4, ... International Committee on Taxonomy of Viruses Index of Viruses - Orthomyxovirus (2006). In: ICTVdB-The Universal Virus ... "CIDRAP - Center for Infectious Disease Research and Policy. University of Minnesota.. *^ "Flu viruses 'can live for decades' on ...
Borna disease virus Family Filoviridae - includes Ebola virus, Marburg virus Family Mymonaviridae Family Nyamiviridae Family ... virus Extra small virus Goji berry chlorosis virus Harmonia axyridis virus 1 Hepelivirus Jingmen tick virus Le Blanc virus ... includes Yellow fever virus, West Nile virus, Hepatitis C virus, Dengue fever virus, Zika virus Family Fusariviridae Family ... Viruses portal Virus classification List of viruses Viral replication Positive/negative-sense Animal viruses Double-stranded ...
Borna disease virus. *BpuJI. *Bradykinin. *Bradykinin receptor. *Brain-specific angiogenesis inhibitor. *Branched chain amino ...
Borna disease virus Enveloped Helical ss(-) V 15. Arteriviridae Arterivirus, equine arteritis virus Enveloped Icosahedral ss IV ... Measles virus, mumps virus, respiratory syncytial virus, Rinderpest virus, canine distemper virus Enveloped Helical ss(-) V ... and foot-and-mouth virus), SARS virus, hepatitis C virus, yellow fever virus, and rubella virus. ... DNA virusesEdit. Further information: DNA virus. Viruses with a DNA genome, except for the DNA reverse transcribing viruses, ...
Thogoto and Borna disease viruses". Virus Res. 95 (1-2): 3-12. doi:10.1016/S0168-1702(03)00159-X. PMID 12921991.. Parameter , ... Virus influenza C. Virus-virus tersebut memiliki kekerabatan yang jauh dengan virus parainfluenza manusia, yang merupakan virus ... Jenis-jenis virusSunting. Dalam klasifikasi virus, virus influenza termasuk virus RNA yang merupakan tiga dari lima genera ... Virus influenza A subtipe H10N7. Virus influenza BSunting. Genus ini memiliki satu spesies, yaitu virus influenza B. influenza ...
... kyasanur forest disease MeSH C02.782.417.505 - lassa fever MeSH C02.782.417.560 - marburg virus disease MeSH C02.782.417.762 - ... borna disease MeSH C02.782.580.250 - filoviridae infections MeSH C02.782.580.250.400 - hemorrhagic fever, ebola MeSH C02.782. ... border disease MeSH C02.782.350.675.106 - bovine virus diarrhea-mucosal disease MeSH C02.782.350.675.200 - classical swine ... marburg virus disease MeSH C02.782.580.600 - paramyxoviridae infections MeSH C02.782.580.600.080 - avulavirus infections MeSH ...
Thogoto and Borna disease viruses". Virus Research. 95 (1-2): 3-12. doi:10.1016/S0168-1702(03)00159-X. PMID 12921991.. ... In virus classification, influenza viruses are RNA viruses that make up four of the seven genera of the family Orthomyxoviridae ... These viruses are only distantly related to the human parainfluenza viruses, which are RNA viruses belonging to the ... how the virus produces disease (pathogenesis), host immune responses, viral genomics, and how the virus spreads (epidemiology ...
... borna disease virus MeSH B04.820.455.300 - filoviridae MeSH B04.820.455.300.200 - ebola-like viruses MeSH B04.820.455.300.650 ... borna disease virus MeSH B04.909.777.455.300 - filoviridae MeSH B04.909.777.455.300.200 - ebola-like viruses MeSH B04.909. ... border disease virus MeSH B04.820.250.700.150 - diarrhea viruses, bovine viral MeSH B04.820.250.700.150.100 - diarrhea virus 1 ... african horse sickness virus MeSH B04.820.630.550.100 - bluetongue virus MeSH B04.820.630.550.400 - hemorrhagic disease virus, ...
Many serious diseases such as rabies, Ebola virus disease, AIDS (HIV), avian influenza, and SARS are caused by viruses. The ... January 1999). "High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health ... Viruses are important pathogens of livestock. Diseases such as foot-and-mouth disease and bluetongue are caused by viruses. ... A virus has either a DNA or an RNA genome and is called a DNA virus or an RNA virus, respectively. The vast majority of viruses ...
Many serious diseases such as Ebola virus disease, AIDS, avian influenza, and SARS are caused by viruses. The relative ability ... Chen C, Chiu Y, Wei F, Koong F, Liu H, Shaw C, Hwu H, Hsiao K. High seroprevalence of Borna virus infection in schizophrenic ... I: dsDNA viruses. II: ssDNA viruses. III: dsRNA viruses. IV: (+)ssRNA viruses. V: (−)ssRNA viruses. VI: ssRNA-RT viruses. VII: ... A virus has either a DNA or an RNA genome and is called a DNA virus or an RNA virus, respectively. The vast majority of viruses ...
Many serious diseases such as Ebola virus disease, AIDS, avian influenza, and SARS are caused by viruses. The relative ability ... Chen C, Chiu Y, Wei F, Koong F, Liu H, Shaw C, Hwu H, Hsiao K. High seroprevalence of Borna virus infection in schizophrenic ... A virus has either a DNA or an RNA genome and is called a DNA virus or an RNA virus, respectively. The vast majority of viruses ... Viruses are important pathogens of livestock. Diseases such as foot-and-mouth disease and bluetongue are caused by viruses.[208 ...
科薩努爾森林病(英語:Kyasanur forest disease) *KFDV(英語:Kyasanur forest disease virus) ... 玻那病毒Borna virusinfection. *馬爾堡病毒. *裂谷熱Rift Valley fever ... N, 580-629(英語:List of ICD-9 codes 580-629: diseases of the genitourinary system)). *Urologic disease(英語:Urologic disease) *腎病變 ... G, 320-359(英語:List of ICD-9 codes 320-359: diseases of the nervous system)). *神經系統疾
... virus yjc.ir The Iranian vaccine neutralizes the British virus mehrnews.com The Iranian vaccine neutralized the British virus ... "The country's first special pharmaceutical economic zone was registered in Alborz". Borna News. Retrieved 3 September 2018. " ... research on the medicine of the disease, launching the 4030 phone line with the help of 2,200 doctors and paramedics for ... the results show that this vaccine also neutralizes the British mutated COVID-19 virus. The vaccine is currently in phase 2 and ...
... using in the treatment of high-dose diseases such as Multiple sclerosis, blood diseases and cancer, "Research and development ... The Iranian vaccine neutralizes the British virus yjc.ir The Iranian vaccine neutralizes the British virus mehrnews.com Iranian ... CS1 maint: discouraged parameter (link) "The First Special Economic Zone of the Country Recorded in Alborz". Borna News. 3 ... Also, "cell therapy" by producing five products for the treatment of skin and heart disease and knee arthritis, production of " ...
There are many wheat diseases, mainly caused by fungi, bacteria, and viruses. Plant breeding to develop new disease-resistant ... Pronin, Darina; Borner, Andreas; Weber, Hans; Scherf, Ann (10 July 2020). "Wheat (Triticum aestivum L.) Breeding from 1891 to ... Both of these diseases are soil borne. Stem rust diseases: Caused by basidiomycete fungi e.g. Ug99 Viral diseases: Wheat ... A wide range of organisms infect wheat, of which the most important are viruses and fungi. The main wheat-disease categories ...
Concerns over the virus began as soon as it began its rapid rise in China and its effects on the international scale became ... A day after, Croatian player Borna Ćorić confirmed he was infected as well, with organizers urging fans and citizens who were ... They left self-isolation on 18 March after none of them showed symptoms of the disease. On 24 March, Croatia national football ... On 12 March, the first recovery was reported, and on 18 March, the first death from the virus was confirmed. The pandemic in ...
The Epstein-Barr virus, for example, is known to be able to dramatically increase the size of lymphoid tissue during acute ... Stroke and other cardiovascular diseases are related to OSA, and those under the age of 70 have an increased risk of early ... Borner, Urs; Tschopp, Kurt (2021-03-30). "Night-to-night variability in obstructive sleep apnea using peripheral arterial ... This repeated brain hypoxia is also considered to be a cause of Alzheimer's disease. Diagnosis of obstructive sleep apnea is ...
In 1971, weaponized smallpox from the island reached a nearby ship, which then allowed the virus to spread to the city of Aral ... In June 2007, BBC World broadcast a documentary called Back From the Brink? made by Borna Alikhani and Guy Creasey, which ... and infectious diseases are common ailments. Liver, kidney, and eye problems can also be attributed to the toxic dust storms. ... Archives of Disease in Childhood. 88 (11): 966-968. doi:10.1136/adc.88.11.966. PMC 1719339. PMID 14612357. Crighton, Eric James ...
  • Persistent Borna Disease Virus infection changes expression and function of astroglial gap junctions in vivo and in vitro. (nih.gov)
  • Neonatal Borna Disease Virus (BDV) infection of the Lewis rat brain leads to dentate gyrus (DG) degeneration, underlying mechanisms are not fully understood. (nih.gov)
  • RT-PCR and Western blot analysis of forebrain (FB) samples revealed a virus dependent reduction of both Cx types 8 but not 4 weeks post infection (p.i. (nih.gov)
  • The research interest in BDV moved to include Asia in the middle of the 1980s, with specific interests in virus infection and human neuropsychiatric diseases. (asmscience.org)
  • The direct effects and mechanisms of BDV infection on brain dysfunction, in the absence of immunopathological brain injury, need to be determined for a better understanding of BD pathogenesis but also for a better understanding of the links between BDV, human infection, and noninflammatory neuropsychiatric diseases. (asmscience.org)
  • Besides its significance for the practitioner, Boma disease virus infection remains to be unique as a disease model: it allows to study most diverse alterations in neurobiological processes. (scialert.net)
  • Borna disease virus infection impairs synaptic plasticity. (inserm.fr)
  • While empirical studies have found that an endogenous bornavirus-like element derived from viral nucleoprotein (itEBLN) in the ground squirrel genome shows antiviral effect on virus replication and de novo infection, the antiviral mechanism, dynamics, and quantitative effect of itEBLN remain unknown. (asm.org)
  • The effect of interferon (IFN) on infection and maintenance of persistent infection of Borna disease (BD) virus in cell cultures was investigated. (microbiologyresearch.org)
  • Acutely BD virus-infected primary rabbit brain and rat lung cells produced significant levels of interferon detectable 3 days post-infection in the culture supernatants. (microbiologyresearch.org)
  • Exogenous homologous IFN completely inhibited the expression of BD virus antigen in acutely infected rabbit brain cells, when added during the first 24 h after infection. (microbiologyresearch.org)
  • IFN added later (2 to 6 days post-infection) reduced virus titres to different degrees depending on the onset of treatment. (microbiologyresearch.org)
  • Thus, MDCK cells, which could not be induced to produce IFN, can be readily persistently infected with BD virus in vitro , and exogenous IFN did not appear to influence persistent BD virus infection. (microbiologyresearch.org)
  • Neonatal Borna Disease Virus (BDV) infection in rats leads to a neuronal loss in the cortex, hippocampus and cerebellum. (biomedcentral.com)
  • The data demonstrate for the first time that a non-lytic persistent virus infection of neurons activates microglia long before any measurable neuronal loss. (biomedcentral.com)
  • Carbone, K. M. / Hematologic consequences of Borna disease virus infection of rat bone marrow and thymus stromal cells . (elsevier.com)
  • Borna disease virus infection of the neonatal rat: developmental brain injury model of autism spectrum disorders. (elsevier.com)
  • This model utilizes neonatal Borna disease virus (BDV) infection of the rat brain as a unique experimental teratogen to study the pathogenesis of neurodevelopmental damage. (elsevier.com)
  • The progression of a clinically manifested infection is lethal (duration of the disease usually 1 - 3 weeks). (laboklin.com)
  • Borna disease virus (BDV) infection in horses either occurs as persistent infection without any clinical symptoms, or is associated with various clinical entities. (fu-berlin.de)
  • Whether Borna disease virus (BDV-1) is a human pathogen remained controversial until recent encephalitis cases showed BDV-1 infection could even be deadly. (biomedcentral.com)
  • On 31 August 2016 the autonomous Community of Madrid, Spain, reported two cases of infection with Crimean-Congo haemorrhagic fever (CCHF) virus. (europa.eu)
  • Following infection, individuals may develop Borna disease, or may remain subclinical, possibly acting as a carrier of the virus. (wikipedia.org)
  • There is some evidence that there may be a relationship between BoDV-1 infection and psychiatric disease. (wikipedia.org)
  • HIV/AIDS and Borna Disease Virus (BDV) in animals help to bring the infection-based model of schizophrenia to the realm of scientific imagination Viruses can influence the human genome. (thefreedictionary.com)
  • In The Neurobiology of Autism (Bauman and Kemper 2005), the authors draw parallels in neurobiology and behavior with autism and another type of infection, neonatal Borna disease virus. (thefreedictionary.com)
  • Infection of newborn Lewis rats with Borna disease virus (neonatal Borna disease [NBD]) results in cerebellar damage without the cellular inflammation associated with infections in later life. (biomedsearch.com)
  • Borna disease virus infection of adult and neonatal rats: models for neuropsychiatric disease. (medigraphic.com)
  • Ludwig H, Bode L. Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology. (medigraphic.com)
  • Varied prevalence of Borna disease virus infection in Arabic, thoroughbred and their cross-bred horses in Iran. (medigraphic.com)
  • Borna disease appears as a sporadic infection affecting small numbers of animals each year. (cdc.gov)
  • Human infection with foamy viruses. (uniklinik-freiburg.de)
  • The researchers in this study aimed to determine the relationship between infection with Borna Disease Virus (BDV) and schizophrenia and other mood disorders, with respect to symptom subtypes and clinical time course. (stanford.edu)
  • Discovered more than 40 years ago, with an efficient vaccine developed against it, the Human Hepatitis B virus (HBV) infection is still a frequent viral disease and a major cause of chronic liver pathogenesis. (frontiersin.org)
  • It's an idea to shake up our notion of mind and body: That a virus or bacterial infection could lead to a personality-changing mental illness. (chicagotribune.com)
  • With depression, the researchers are not sure whether the fault lies with an actual virus or an auto-immune condition that mimics a viral infection. (chicagotribune.com)
  • Anti-idiotypic antibody as potential serodiagnostic reagent for detection of bluetongue virus infection. (asm.org)
  • Differential genes expression in rats-hippocampus and -cerebellum after Borna disease virus infection. (mpg.de)
  • abstract = "Borne disease virus (BDV) was previously believed to have a strict tropism for the nervous system. (elsevier.com)
  • Recent discoveries to diagnose BDV-infections intra vitam indicate blood mononuclear cells (PBMCs) to play a key-role in pathogenesis of disease symptoms of horses and man. (fu-berlin.de)
  • Gosztonyi G, Ludwig H. Borna disease--neuropathology and pathogenesis. (medigraphic.com)
  • Although many viruses use various strategies to control the cell death machinery by encoding anti-apoptotic virulence factors, it is now becoming clear that, in addition to their role in inhibiting apoptosis, these factors function in multiple immune and metabolic pathways to promote fitness and pathogenesis. (jove.com)
  • The pathogenesis of Borna disease (BD) has been proposed to be immune-mediated, mainly through the effects of cytotoxic T cells. (maxshouse.com)
  • In serum samples from diseased cats, antibodies to Borna disease virus were demonstrated. (maxshouse.com)
  • The Borna virus is a non-segmented, enveloped RNA virus which constitutes the only member of the family Bornaviridae. (laboklin.com)
  • Borna disease viruses 1 and 2 are neurotropic viruses and members of the Bornaviridae family within the Mononegavirales order. (wikipedia.org)
  • Before this discovery, the family Bornaviridae contained only 1 species, Borna disease virus (BDV). (thefreedictionary.com)
  • Avian bornavirus (ABV) is a newly discovered member of the family Bornaviridae that has been associated with the development of a lethal neurologic syndrome in birds, termed proventricular dilatation disease (PDD). (cdc.gov)
  • Borna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. (nel.edu)
  • We now report the identification of BDV RNA end infectious virus in thymus cells from rats infected either as neonates (PTI- NB) or as adults (4 weeks of age). (elsevier.com)
  • We also report the association between BDV in the thymus with the lack, or loss, of encephalitis in neonatally inoculated rats or adult-inoculated rats during the chronic stage of disease. (elsevier.com)
  • Neutralizing antibodies in Borna disease virus-infected rats. (medigraphic.com)
  • Identification of differentially expressed genes in brains of newborn Borna disease virus-infected rats in the absence of inflammation. (uniklinik-freiburg.de)
  • Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with Borna disease virus. (columbia.edu)
  • Proventricular dilatation disease (PDD) is a suspected viral disease that has been given many other names over the years, including macaw wasting disease (as it was thought to be prevalent in this species), neuropathic ganglioneuritis, and lymphoplasmocytic ganglioneuritis. (avianavenue.com)
  • Borna disease , a viral disease of warm-blooded animals, notably horses and sheep , characterized by inflammation of the brain and spinal cord . (britannica.com)
  • A viral disease transmitted by mosquitoes and is endemic in tropical and subtropical regions. (citizendium.org)
  • The detection of live virus and mRNA (PCR or in situ hybridization) strongly indicates virus replication in monocytes. (fu-berlin.de)
  • The hypothesis that microbial infections may be linked to mental disorders has long been addressed for Borna disease virus (BDV), but clinical and epidemiological evidence remained inconsistent due to non-conformities in detection methods. (beds.ac.uk)
  • Rapid detection of herpes simplex virus and varicella-zoster virus infections by real-time PCR. (uniklinik-freiburg.de)
  • Comparison of commercial enzyme immunoassay kits with plaque reduction neutralization test for detection of measles virus antibody. (asm.org)
  • Detection of Borna disease virus RNA in formalin-fixed, paraffin-embedded brain tissues by nested PCR. (asm.org)
  • Borna disease virus (BDV) is well known as a neurotropic virus، however، its role in human neurological diseases such as schizophrenia and bipolar disorder is still unclear. (magiran.com)
  • In humans, the virus has been linked (albeit inconclusively) to various psychiatric disorders including schizophrenia. (scienceblogs.com)
  • A Bayesian analysis of Borna disease virus 1 suggests that the current strains diversified ~300 years ago and that avian-host bornaviruses evolved considerably earlier than this. (wikipedia.org)
  • It has been a controversial issue whether this virus also infects humans and is there linked to neuropsychiatric disorders. (laboklin.com)
  • Many researchers are now investigating the claim that a simple virus known to infect horses, could be a major factor in the cause of mental illness in humans. (sciencephoto.com)
  • Borna disease virus (BDV) is an evolutionary old RNA virus, which infects brain and blood cells of humans, their primate ancestors, and other mammals. (biomedcentral.com)
  • Some studies have claimed a link between exposure to the Borna disease virus and mental illness in humans, but such a connection has not been conclusively proven. (britannica.com)
  • Borna disease virus-1 (BoDV-1) was recently discovered as cause of severe and often fatal encephalitis in humans. (rki.de)
  • Due to the fact that this would be a first incidence of a previously unknown disease, there is no definitive method of testing for VSBV-1, or for Borna disease viruses in humans. (healthmap.org)
  • The role of BoDV-1 and -2 in human illness is controversial and it is yet to be established whether BoDV-1 or -2 cause any overt disease in humans. (wikipedia.org)
  • Borna virus has been detected in humans, and researchers have presented evidence connecting these infections with psychiatric disorders. (wikipedia.org)
  • Humans and viruses have been coevolving for millennia. (pnas.org)
  • Insect-borne virus, of the genus Alphavirus , that is transmitted to humans by virus-carrying Aedes mosquitoes. (citizendium.org)
  • DNA viruses that cause upper respiratory tract infections, conjunctivitis, and other infections in humans. (citizendium.org)
  • The virus has a predilection for the hypothalamus -- the part of the brain that, in humans, mediates our moods," Amsterdam says. (chicagotribune.com)
  • That led Amsterdam and Hornig-Rohan to start looking for this virus in humans. (chicagotribune.com)
  • It is more difficult to disclose infections by growing the virus in tissue culture and by animal inoculation. (scialert.net)
  • The ability of Boma disease virus to cause persistent infections of neurons most probably plays the key role in pathogenetic events. (scialert.net)
  • The study published today in the renowned medical journal „The Lancet Infectious Diseases" collects and characterizes known human infections with Borna Disease Virus (BoDV-1). (idw-online.de)
  • This document assesses the risk associated with the outbreak of Zika virus infections, considered as an emerging disease, to public health in the EU/EEA and the risk to EU/EEA citizens in order to anticipate future developments. (europa.eu)
  • Counter-claims state that Borna virus infections are not cleared by amantadine. (wikipedia.org)
  • Representing a major addition to the world literature on the subject, Viral Infections and Global Change explores trends of paramount concern globally, regarding the emergence and reemergence of vector-borne and zoonotic viruses. (wiley.com)
  • Viral Infections and Global Change is an indispensable resource for research scientists, epidemiologists, and medical and veterinary students working in ecology, environmental management, climatology, neurovirology, virology, and infectious disease. (wiley.com)
  • Bode L, Riegel S, Lange W, Ludwig H. Human infections with Borna disease virus: seroprevalence in patients with chronic diseases and healthy individuals. (medigraphic.com)
  • Bode L, Durrwald R, Ludwig H. Borna virus infections in cattle associated with fatal neurological disease. (medigraphic.com)
  • The unfolded protein response in virus infections. (frontiersin.org)
  • Researchers are finding evidence that some diseases with only psychological symptoms could be triggered by infections or abnormalities of the immune system. (chicagotribune.com)
  • PC inhibitors are suggested as promising antiviral drugs for quite a number of viruses causing severe infections. (springer.com)
  • A similar disease had been observed in horses, sheep, and cattle for more than 100 years. (cdc.gov)
  • Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. (sciencemag.org)
  • BoDV-1, which has long been known as the causative agent of Borna disease in horses, sheep and other mammals, was first identified as the cause of severe human encephalitis in 2018. (idw-online.de)
  • It is of clinical relevance particularly in horses, in cats (where the disease is also called "staggering disease") and in sheep. (laboklin.com)
  • this disease has been reported for over two centuries ago in horses, sheep and cats in Central Europe and some regions of Asia. (scirp.org)
  • BoDV-1 is known to cause neurological disease in horses and sheep mainly in South and Central Germany. (rki.de)
  • Borna diseases viruses 1 and 2 appear to have wide host ranges, having been detected in horses, cattle, sheep, dogs and foxes. (wikipedia.org)
  • citation needed] Borna disease in sheep and horses arises after a four-week incubation period followed by the development of immune-mediated meningitis and encephalomyelitis. (wikipedia.org)
  • The most common causes for viral encephalitis in sheep include maedi-visna virus, Borna disease virus, and rabies virus. (thefreedictionary.com)
  • Borna disease (BD) is a fatal neurologic disorder in horses and sheep. (thefreedictionary.com)
  • Vahlenkamp TW, Konrath A, Weber M, Muller H. Persistence of Borna disease virus in naturally infected sheep. (medigraphic.com)
  • Lundgren AL, Czech G, Bode L, Ludwig H. Natural Borna disease in domestic animals others than horses and sheep. (medigraphic.com)
  • BDV causes a neurologic syndrome, Borna disease, which is restricted to central Europe, where it is found primarily in horses and sheep. (cdc.gov)
  • Pyrosequencing of cDNA from brains of parrots with proventricular dilatation disease (PDD), an unexplained fatal inflammatory central, autonomic, and peripheral nervous system disease, showed 2 strains of a novel Borna virus. (elsevier.com)
  • Four strains of BDV have been described: Borna V, Borna HE/80, Borna No/98 and Borna H1766. (scirp.org)
  • Strain H1766 has 95% - 98% homology with strains V and He/80, and only 81% with Borna No/98. (scirp.org)
  • The ion channel blockers amantadine and rimantadine are of limited use because of a lack of activity against influenza B virus, side effects, and the rapid emergence of resistant virus strains ( 9 ). (asm.org)
  • To favor their replication, viruses express proteins that target diverse mammalian cellular pathways. (sigmaaldrich.com)
  • These studies provided insights into how NNS RNA viruses synthesize 5′-capped mRNAs using their RNA-dependent RNA polymerase L proteins equipped with an unconventional mRNA capping enzyme, namely GDP polyribonucleotidyltransferase (PRNTase), domain. (frontiersin.org)
  • PRNTase or PRNTase-like domains are evolutionally conserved among L proteins of all known NNS RNA viruses and their related viruses belonging to Jingchuvirales , a newly established order, in the class Monjiviricetes , suggesting that they may have evolved from a common ancestor that acquired the unique capping system to replicate in a primitive eukaryotic host. (frontiersin.org)
  • Alternatively, agents preventing cleavage of viral surface (glyco)proteins block fusion capacity and multicyclic virus replications. (springer.com)
  • In this study, we experimentally and theoretically investigated the dynamics of how an extant bornavirus, Borna disease virus 1 (BoDV-1), spreads and replicates in uninfected, BoDV-1-infected, and itEBLN-expressing cultured cells. (asm.org)
  • The new virus, which has been provisionally termed 'variegated squirrel 1 bornavirus' or VSBV-1, was found to be unique from the previously known and described bornaviruses (1). (healthmap.org)
  • Almost all of these hidden sequences match the N gene of the most famous bornavirus - BDV or Borna disease virus. (scienceblogs.com)
  • CiteSeerX - Borna Disease Virus Phosphoprotein Represses p53-Mediated. (yasni.com)
  • Modulation of Borna Disease Virus Phosphoprotein Nuclear Localization. (yasni.com)
  • Active Borna Disease Virus polymerase complex requires a distinct nucleoprotein-to-phosphoprotein ratio but no viral X protein. (uniklinik-freiburg.de)
  • The causative agent was later found to be a negative-stranded RNA virus, which may also be a human pathogen. (cdc.gov)
  • This virus is the causative agent of congenital disorder of lambs and reproductive problems in ewes. (kitpcr.com)
  • It was first described as the causative agent of a neurologic disease outbreak among horses in the German town of Borna in the 1800s (4, 8). (healthmap.org)
  • Although Borna disease viruses 1 and 2 are mainly seen as the causative agent of Borna disease in horses and other animals, they are also controversially discussed as human infectious agents and therefore as potential zoonotic agents. (wikipedia.org)
  • Emerging Infectious Diseases , 15 (9), 1452. (cdc.gov)
  • Emerging Infectious Diseases , 14 (12), 1883-1886. (elsevier.com)
  • It is a linear negative-sense single stranded RNA virus in the order Mononegavirales. (wikipedia.org)
  • These are the only animal viruses within the order Mononegavirales to do this. (wikipedia.org)
  • Borna disease virus (BDV), the prototype of a new family within the order Mononegavirales, is unusual in its nuclear localization for replication and transcription and use of RNA splicing for gene expression. (asm.org)
  • Borna disease virus (BDV) is an enveloped virus with a nonsegmented negative-strand RNA genome whose organization is characteristic of Mononegavirales. (eurekamag.com)
  • Non-segmented negative strand (NNS) RNA viruses belonging to the order Mononegavirales are highly diversified eukaryotic viruses including significant human pathogens, such as rabies, measles, Nipah, and Ebola. (frontiersin.org)
  • The order Mononegavirales comprises highly diversified eukaryotic viruses with a monopartite negative strand RNA genome (rarely bipartite genomes), which includes important human pathogens [e.g., rabies virus (RABV), measles virus (MeV), Nipah virus (NiV), human respiratory syncytial virus (HRSV), Ebola virus (EBOV)] ( Lamb, 2013 ). (frontiersin.org)
  • Virus of the Mononegavirales species that causes Borna disease. (citizendium.org)
  • Borna disease was first described in 1885 as "heated head disease" of cavalry horses in 1885 in the town of Borna, Germany. (wikipedia.org)
  • The virus name is derived from the town of Borna in Saxony, Germany, which suffered an epidemic of the disease in horses in 1885. (wikipedia.org)
  • tT was actually named for the town of Borna, Germany, where a killer epidemic of cavalry horses in 1885 led to its discovery. (scienceblogs.com)
  • In 2008, identification of the previously unknown avian Borna virus (ABV) in birds infected with PDD was achieved for the first time. (laboklin.com)
  • Avian Borna viruses are RNA viruses which show high genetic divergence. (laboklin.com)
  • We will speak about Avian Borna Virus in an upcoming section). (avianavenue.com)
  • Avian bornaviruses, a group of related viruses, have been reported, yet not proven, as the cause of proventricular dilatation disease (PDD), a disease of pet parrots. (wikipedia.org)
  • Borna disease virus was named after the town of Borna in Saxony, southeastern Germany, where in 1885 many horses in a German cavalry regiment died of a fatal neurologic disease. (cdc.gov)
  • Its name derives from the city in Saxony where the condition was first described in 1894, but the disease occurs in europe , N. africa , and the Near East. (lookfordiagnosis.com)
  • In 2015, German officials reported a cluster of three acute fatal encephalitis cases in the Saxony-Anhalt region to the Early Warning and Response System of the European Center for Disease Control (ECDC) (4). (healthmap.org)
  • The Borna disease viruses 1 and 2 (BoDV-1 and BoDV-2) are members of the species Mammalian 1 orthobornavirus and cause Borna disease in mammals. (wikipedia.org)
  • Horse and human P24 have no species-specific amino acid residues, suggesting that the two viruses are related. (wikipedia.org)
  • The great adaptability of the virus to different animal species and its affinity for neurons allow to investigate clinical alterations involving the CNS and to quantitate the virological and immunological interactions of the agent with nerve cells in the brain and the eye. (scialert.net)
  • Numerous species of mammals are susceptible to this virus. (laboklin.com)
  • The disease has been identified in a wide variety of birds, including 80 species of psittacines, toucans, honey creepers, weaver finches, water fowl, raptors and passerines. (avianavenue.com)
  • Borna disease, also known as sad horse disease, is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease viruses 1 and 2 (BoDV-1/2), both of which are members of the species Mammalian 1 orthobornavirus. (wikipedia.org)
  • It is considered a serious disease because many of these birds are highly endangered, and several affected species depend on captive breeding for their survival. (cdc.gov)
  • Family of double-stranded DNA viruses with icosahedral symmetry, usually found in the respiratory tract of the host species and often associated with respiratory diseases. (citizendium.org)
  • Species of the genus Orthohepadnavirus , characterized by the causing the disease Hepatitis B, which can also lead to cirrhosis and hepatocellular carcinoma, and is transmitted by contaminated blood or blood derivatives. (citizendium.org)
  • Prevalence studies of rodents collected in Turkey revealed 6% seropositivity to Puumala virus in Microtus voles and no appearance of hantavirus antibodies in the Apodemus species of rodents (9). (thefreedictionary.com)
  • Borna disease virus (BDV) is a neurotropic agent with capacity to cause encephalomyelitis in a wide range of animal species, including horses and cats. (maxshouse.com)
  • Newcastle disease is caused by a paramyxovirus, which can affect all species, and causes tremors, paralysis, and opisthotonos (where the head and tail are bent upward while the abdomen is pushed down). (mickaboo.org)
  • IMPORTANCE Accumulating evidence suggests that some endogenous viral elements (EVEs), including endogenous retroviruses and endogenous nonretroviral virus elements, have acquired functions in the host as a result of long-term coevolution. (asm.org)
  • As a result, Horie and Honda christened their newfound sequences as EBLNs (or "endogenous Borna-like N" elements). (scienceblogs.com)
  • 2010. Endogenous non-retroviral RNA virus elements in mammalian genomes. (scienceblogs.com)
  • Comments on the article 'Borna Disease Virus in Human Brains with a Rare Form of Hippocampal Degeneration But Not in Brains of Patients with Common Neuropsychiatric Disorders,' by M. Czygan, W. Hallensleben et al, published in the 1999 issue of the 'Journal of Infectious Diseases. (ebscohost.com)
  • This virus triggers the co-called Borna disease in mammals and the proventricular dilatation disease in birds. (laboklin.com)
  • Viruses of the Parvoviridae family, that contain DNA in an icosahedral protein shell and cause disease in many vertebrates, especially mammals such as dogs and cattle. (citizendium.org)
  • The virus infects neurons and astrocytes, and the resulting disease appears to be mediated by an immunopathologic response of the host to the virus. (cdc.gov)
  • Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential. (sigmaaldrich.com)
  • One salient example is the X protein of Borna disease virus, which is expressed both at the mitochondria and in the nucleus. (sigmaaldrich.com)
  • Unprocessed envelope protein p57 is thought to be involved in attachment of the virus to its cell surface receptor. (cusabio.com)
  • An Interferon-gamma-binding protein of novel structure encoded by the fowlpox virus. (uniklinik-freiburg.de)
  • Bunyamwera virus nonstructural protein NSs counteracts interferon regulatory factor 3-mediated induction of early cell deaath. (uniklinik-freiburg.de)
  • Identification of a novel C-terminal cleavage of Crimean-Congo hemorrhagic fever virus PreGN that leads to generation of an NSM protein. (springer.com)
  • The risk for EU/EEA citizens to become infected with communicable diseases during the 2019 hajj is considered low, thanks to the vaccination requirements for travelling to Makkah (Mecca) and the Saudi Arabian preparedness plans that address the management of health hazards during and after hajj. (europa.eu)
  • Fatal Encephalitis Associated with Borna Disease Virus 1. (nih.gov)
  • An epornitic of this disease is currently occurring in imported and captive-bred psittacine birds in North America and Europe. (avianavenue.com)
  • Consequently, debate about the role of BDV in psychiatric diseases remains alive. (wikipedia.org)
  • The impact of Borna Disease virus (BDV) in Asian psychiatric patients remains to be clear. (org.ir)
  • However, not all researchers consider the link between BoDV-1 and human psychiatric disease to be conclusively proven. (wikipedia.org)
  • Borna disease virus circulating immunocomplex positivity and psychopathology in psychiatric patients in the Czech Republic. (nel.edu)
  • State psychiatric hospitals used to be filled with people who had tertiary syphilis," an infectious disease, he points out. (chicagotribune.com)
  • Serum autoantibody against the muscarinic cholinergic receptor (mAChR) was increased in some patients with chronic fatigue syndrome (CFS) or psychiatric disease. (ebscohost.com)
  • Quantifying antiviral effect based on time course data sets, we found that the antiviral effects of itEBLN are estimated to be 75% and 34% on intercellular virus spread and intracellular virus replication, respectively. (asm.org)
  • This discrepancy between intercellular virus spread and intracellular viral replication suggests that viral processes other than the replication of viral ribonucleoprotein complex (RNP) contributed to the suppression of virus spread in itEBLN-expressing cells. (asm.org)
  • Over the past 40 years, vesicular stomatitis virus (VSV), closely related to rabies virus, has served as a paradigm to study the fundamental molecular mechanisms of transcription and replication of NNS RNA viruses. (frontiersin.org)
  • Replication of primate foamy viruses in natural and experimental hosts. (uniklinik-freiburg.de)
  • Virus classification is based mainly on phenotypic characteristics, including morphology , nucleic acid type, mode of replication, host organisms , and the type of disease they cause. (wikidoc.org)
  • These groups are designated by Roman numerals and separate viruses based on their mode of replication, and genome type. (wikidoc.org)
  • Baltimore classification (first defined in 1971) is a classification system which places viruses into one of seven groups depending on a combination of their nucleic acid ( DNA or RNA ), strandedness (single-stranded or double-stranded), and method of replication . (wikidoc.org)
  • Nonetheless, the virus' genome has been characterised. (wikipedia.org)
  • Borna disease virus (BDV) is a non-segmented, negative-strand RNA virus that replicates and transcribes its genome in the nucleus of infected cells. (columbia.edu)
  • Borna Disease Virus (BDV) is an enveloped virus with a negative-strand RNA, non-segmented, non cytolytic and neurotrophic, with a genome of approximately 8.9 Kb. (scirp.org)
  • Classifying viruses according to their genome means that those in a given category will all behave in a similar fashion, offering some indication of how to proceed with further research. (wikidoc.org)
  • The human genome is littered with the remains of viruses that, in ages past, integrated their genes into the DNA of our ancestors. (scienceblogs.com)
  • Background: Two large-scale genome-wide association studies have identified rs610932 and rs670139 polymorphisms within the MS4A gene cluster as being significantly associated with susceptibility to Alzheimer's disease (AD) in those with European ancestry. (eurekaselect.com)
  • The mechanisms whereby Borna disease virus (BDV) can impair neuronal function and lead to neurobehavioral disease are not well understood. (inserm.fr)
  • This question is of importance since BDV is a non-lytic neurotropic virus and does not kill neurons in vitro , suggesting that activation of microglia may trigger neuronal damage and/or exacerbate initial subtle dysfunctions produced by the virus. (biomedcentral.com)
  • The virus has a strong neurotropism and triggers non-purulent meningoencephalitis, associated with anorexia, apathy, somnolence and multiple neuronal dysfunctions. (laboklin.com)
  • Neuronal retrograde transport of Borna disease virus occurs in signalling endosomes. (google.fr)
  • It has since been recognized as an often-fatal disease affecting a range of livestock and domestic animals (5). (healthmap.org)
  • The virus is maintained in bicolored white-toothed shrews (Crocidura leucodon). (rki.de)
  • Proventricular dilatation disease (PDD) is a globally distributed, serious disease particularly affecting psittacines (large parrots) like macaws, amazons or grey parrots. (laboklin.com)
  • Borna virus, which can result in Proventricular Dilatation Disease (PDD), attacks the nerves. (mickaboo.org)
  • A few people have tested positive for this virus, and a disproportionate number of those are also clinically depressed, leading researchers to suspect a connection. (chicagotribune.com)
  • The virus, named for an 1894 outbreak among horses near Borna, Germany, was described by German researchers as making the horses sad before it destroyed their nervous systems and killed them. (chicagotribune.com)
  • Virus expert Hillary Koprowski of Thomas Jefferson University, who has collaborated with the Penn researchers, is skeptical that the depressed people really have the virus. (chicagotribune.com)
  • BDV is a neurotropic virus that causes changes. (nel.edu)
  • Peripheral and intracerebral T cell immune response in cats naturally infected with Borna disease virus. (maxshouse.com)
  • In addition, the significance of BDV or a BDV-related virus as a human pathogen can now be more directly examined. (sciencemag.org)
  • The Borna disease virus (BDV), a potential human pathogen, provides a unique model to study such mechanisms. (pasteur.fr)
  • This review highlights the current understanding of the mechanisms of the ER stress activation by Human Hepatitis B virus (HBV), a deadly pathogen affecting more than 350 million people worldwide. (frontiersin.org)
  • BDV cell entry follows a receptor-mediated endocytosis pathway, which is initiated by the recognition of an as-yet-unidentified receptor at the cell surface by the virus glycoprotein G. BDV G is synthesized as a precursor (GPC) that is cleaved by the cellular protease furin to produce the mature glycoproteins GP1 and GP2, which have been implicated in receptor recognition and pH-dependent fusion events, respectively. (eurekamag.com)
  • Analysis of the glycoprotein gene of Tacaribe virus and neutralization-resistant variants. (springer.com)
  • The Borna disease virus (BDV) is caused by an infectious agent - a negative-sense, single-stranded RNA virus. (psychcentral.com)
  • BDV is a single stranded RNA virus that preferentially invades the central nervous system - leading to cognitive changes and encephalopathy (6-7). (healthmap.org)
  • viruses possess single-stranded DNA and include such virus families as Parvoviridae and the important bacteriophage M13 . (wikidoc.org)
  • viruses possess positive-sense single-stranded RNA genomes. (wikidoc.org)
  • Virus spread occurs mainly intraaxonally. (scialert.net)
  • It is important that in particular unclear cases of encephalitis in regions where BoDV-1 occurs are investigated for presence of the virus" says Prof. Dr. Martin Beer, head of the Institute of Diagnostic Virology of the FLI. (idw-online.de)
  • Borna disease in the horse gives rise to signs like: Unusual posture, gait and ear positions Movement Disturbances (principally ataxia or excess movement) The mode of transmission of BoDV-1/2 is unclear but probably occurs through intranasal exposure to contaminated saliva or nasal secretions. (wikipedia.org)
  • A negative result does therefore not entirely rule out PDD, as there may be other virus variants, which have not yet been described, leading to this disease. (laboklin.com)
  • Readers learn about the history of this unique science, how viruses are named, how their genes work, how they copy and package themselves, how they interact with their hosts, how immune systems counteract viruses, and how viruses travel from host to host. (credoreference.com)
  • It's possible that BDV creates disease-causing mutations by inserting its genes into the wrong parts of our genomes. (scienceblogs.com)

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