Borna disease virus: A species in the genus Bornavirus, family BORNAVIRIDAE, causing a rare and usually fatal encephalitic disease in horses and other domestic animals and possibly deer. Its name derives from the city in Saxony where the condition was first described in 1894, but the disease occurs in Europe, N. Africa, and the Near East.Borna Disease: An encephalomyelitis of horses, sheep and cattle caused by BORNA DISEASE VIRUS.Rats, Inbred LewViruses, Unclassified: Viruses whose taxonomic relationships have not been established.Mononegavirales: An order comprising four families of eukaryotic viruses possessing linear, non-segmented, negative-strand RNA genomes. The families are BORNAVIRIDAE; FILOVIRIDAE; PARAMYXOVIRIDAE; and RHABDOVIRIDAE.Viral Proteins: Proteins found in any species of virus.Parapoxvirus: A genus of the family POXVIRIDAE, subfamily CHORDOPOXVIRINAE, which infect ungulates and may infect humans. ORF VIRUS is the type species.LiechtensteinHorse Diseases: Diseases of domestic and wild horses of the species Equus caballus.Bornaviridae: A family in the order MONONEGAVIRALES comprising one genus Bornavirus. This family has a unique form of mRNA processing: replication and transcription takes place in the nucleus.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Horses: Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Nucleoproteins: Proteins conjugated with nucleic acids.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Meningoencephalitis: An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.Encephalitis, Viral: Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.Antigens, Viral: Substances elaborated by viruses that have antigenic activity.Vero Cells: A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.Orf virus: The type species of PARAPOXVIRUS which causes a skin infection in natural hosts, usually young sheep. Humans may contract local skin lesions by contact. The virus apparently persists in soil.Cercopithecus aethiops: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Genome, Viral: The complete genetic complement contained in a DNA or RNA molecule in a virus.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Love: Affection; in psychiatry commonly refers to pleasure, particularly as it applies to gratifying experiences between individuals.Philology, Romance: The study of literature written in the Romance languages (French, Spanish, Italian, and others descended from Latin), including grammar, etymology, criticism, literary history, and language and linguistic history.Explosive Agents: Substances that are energetically unstable and can produce a sudden expansion of the material, called an explosion, which is accompanied by heat, pressure and noise. Other things which have been described as explosive that are not included here are explosive action of laser heating, human performance, sudden epidemiological outbreaks, or fast cell growth.ArchivesRefrigeration: The mechanical process of cooling.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Newcastle disease virus: The most well known avian paramyxovirus in the genus AVULAVIRUS and the cause of a highly infectious pneumoencephalitis in fowl. It is also reported to cause CONJUNCTIVITIS in humans. Transmission is by droplet inhalation or ingestion of contaminated water or food.Neuroglia: The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.Cell Adhesion Molecules, Neuronal: Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Retina: The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.Psychoses, Alcoholic: A group of mental disorders associated with organic brain damage and caused by poisoning from alcohol.RNA Viruses: Viruses whose genetic material is RNA.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Interferons: Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Interferon Type I: Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).Central Nervous System Infections: Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.Taste: The ability to detect chemicals through gustatory receptors in the mouth, including those on the TONGUE; the PALATE; the PHARYNX; and the EPIGLOTTIS.Foot-and-Mouth Disease Virus: The type species of APHTHOVIRUS, causing FOOT-AND-MOUTH DISEASE in cloven-hoofed animals. Several different serotypes exist.Newcastle Disease: An acute febrile, contagious, viral disease of birds caused by an AVULAVIRUS called NEWCASTLE DISEASE VIRUS. It is characterized by respiratory and nervous symptoms in fowl and is transmissible to man causing a severe, but transient conjunctivitis.PhosphoproteinsApathy: Lack of emotion or emotional expression; a disorder of motivation that persists over time.Salivation: The discharge of saliva from the SALIVARY GLANDS that keeps the mouth tissues moist and aids in digestion.Animal Welfare: The protection of animals in laboratories or other specific environments by promoting their health through better nutrition, housing, and care.ShrewsVeterinarians: Individuals with a degree in veterinary medicine that provides them with training and qualifications to treat diseases and injuries of animals.Insectivora: An order of insect eating MAMMALS including MOLES; SHREWS; HEDGEHOGS and tenrecs.Fluorescent Antibody Technique, Indirect: A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Chemistry, Agricultural: The science of the chemical composition and reactions of chemicals involved in the production, protection and use of crops and livestock. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

A serosurvey of Borna disease virus infection in wild rats by a capture ELISA. (1/148)

For a serological diagnostic test for Borna disease (BD), we developed a capture ELISA with specificity and sensitivity based on detection of antibodies against BD virus (BDV) p40 protein. Using our capture ELISA system, the antibody response of rats inoculated intracerebrally with BDV at 4 weeks after birth showed a sharp increase from 1 to 4 weeks postinoculation (p.i.) and a steady level after 5 weeks p.i. To investigate prevalence of BDV infection among wild rats, we examined sera of Rattus norvegicus in Kami-iso town, Oshima district, Hokkaido, suggesting that rats in this area had not been infected by BDV.  (+info)

T cell ignorance in mice to Borna disease virus can be overcome by peripheral expression of the viral nucleoprotein. (2/148)

Infection of neonates with Borna disease virus (BDV) induces severe meningoencephalitis and neurological disorder in wild-type but not in beta(2)-microglobulin-deficient mice of strain MRL (H-2(k)). Temporary in vivo depletion of CD8(+) T cells delayed BDV-induced disease for several weeks. Depletion of CD4(+) T cells had a similar beneficial effect, indicating that the BDV-induced neurological disorder in mice is a CD4(+) T cell-dependent immunopathological process that is mediated by CD8(+) T cells. Lymphocytes prepared from brains of diseased mice were mainly from the CD8(+) T cell subset. They showed up-regulation of activation markers and exerted strong MHC I-restricted cytotoxic activity against target cells expressing the BDV nucleoprotein p40. Infection of B10.BR (H-2(k)) or congenic C57BL/10 (H-2(b)) mice resulted in symptomless, lifelong persistence of BDV in the brain. Superinfection with a recombinant vaccinia virus expressing BDV p40 but not with other vaccinia viruses induced severe neurological disease and encephalitis in persistently infected B10.BR mice but not in persistently infected C57BL/10 mice, indicating that the disease-inducing T cell response is restricted to the nucleoprotein of BDV in H-2(k) mice. Our results demonstrate that the cellular arm of the immune system may ignore the presence of a replicating virus in the central nervous system until proper antigenic stimulation at a peripheral site triggers the antiviral response.  (+info)

Detection of borna disease virus-reactive antibodies from patients with psychiatric disorders and from horses by electrochemiluminescence immunoassay. (3/148)

The prevalence of Borna disease virus (BDV)-specific antibodies among patients with psychiatric disorders and healthy individuals has varied in several reports using several different serological assay methods. A reliable and specific method for anti-BDV antibodies needs to be developed to clarify the pathological significance of BDV infections in humans. We developed a new electrochemiluminescence immunoassay (ECLIA) for the antibody to BDV that uses two recombinant proteins of BDV, p40 and p24 (full length). Using this ECLIA, we examined 3,476 serum samples from humans with various diseases and 917 sera from blood donors in Japan for the presence of anti-BDV antibodies. By ECLIA, 26 (3.08%) of 845 schizophrenia patients and 9 (3.59%) of 251 patients with mood disorders were seropositive for BDV. Among 323 patients with other psychiatric diseases, 114 with neurological diseases, 75 with chronic fatigue syndrome, 85 human immunodeficiency virus-infected patients, 50 with autoimmune diseases including rheumatoid arthritis and systemic lupus erythematosis and 17 with leprosy, there was no positive case except one case each with alcohol addiction, AIDS, and dementia. Although 19 (1.36%) of 1,393 patients with various ocular diseases, 10 (1.09%) of 917 blood donors, and 3 (4.55%) of 66 multitransfused patients were seropositive for BDV-specific antigen, high levels of seroprevalence in schizophrenia patients and young patients (16 to 59 years old) with mood disorders were statistically significant. The immunoreactivity of seropositive sera could be verified for specificity by blocking with soluble p40 and/or p24 recombinant protein. Anti-p24 antibody was more frequent than p40 antibody in most cases, and in some psychotic patients antibody profiles showed only p40 antibody. Although serum positive for both p40 and p24 antibodies was not found in this study, the p40 ECLIA count in schizophrenia patients was higher than that of blood donors. Furthermore, we examined 90 sera from Japanese feral horses. Antibody profiles of control human samples are similar to that of naturally BDV-infected feral horses. We concluded that BDV infection was associated in some way with psychiatric disorders.  (+info)

Borna disease virus in human brains with a rare form of hippocampal degeneration but not in brains of patients with common neuropsychiatric disorders. (4/148)

To estimate the frequency of persistent Borna disease virus (BDV) infections of the human central nervous system and to determine which neuropsychiatric disorders might be associated with this viral infection, reverse transcription-nested polymerase chain reaction was used to screen a large collection of autopsy brain samples for the presence of BDV-specific nucleic acids. The presence of BDV RNA was found in 3 brains of persons with psychiatric symptoms and prominent hippocampal degeneration previously reported to be positive by others. However, no BDV RNA was detected in 86 randomly collected brains from persons with various psychiatric disorders, including schizophrenia, affective disorders, and Alzheimer's disease, or from suicide victims or in 52 brains from healthy controls. Furthermore, no BDV-RNA was detected in 16 surgical brain samples from persons with epilepsy-associated hippocampal sclerosis. These results indicate that life-long persistent BDV infections are rare in humans and that such infections may be associated with certain forms of hippocampal degeneration.  (+info)

Borna disease virus infection in domestic cats: evaluation by RNA and antibody detection. (5/148)

Borna disease virus (BDV) infection has been suggested to cause spontaneous neurological disease in cats referred to as staggering disease. However the evaluation of BDV infection in neurologically asymptomatic cats remained unclear. In the present study, BDV infected, asymptomatic cats in Tokyo were surveyed both by the presence of plasma antibodies against BDV-p24 and -p40 and by RNA detection in peripheral blood mononuclear cells. Seven of 32 domestic cats (21.9%) were serologically or genetically judged to be BDV-infected. Six cats were positive for anti-BDV antibody and two cats were positive for BDV RNA. Within the 2 RNA-positive cats, only one was positive for anti-BDV antibodies. Furthermore, the findings of anti-BDV-p40 and anti-BDV-p24 antibody-positive cats did not completely overlap. These results suggest that there are neurologically asymptomatic domestic cats infected with BDV present in the Tokyo area.  (+info)

Synaptic pathology in Borna disease virus persistent infection. (6/148)

Borna disease virus (BDV) infection of newborn rats leads to a persistent infection of the brain, which is associated with behavioral and neuroanatonomical abnormalities. These disorders occur in the absence of lymphoid cell infiltrates, and BDV-induced cell damage is restricted to defined brain areas. To investigate if damage to synaptic structures anteceded neuronal loss in BDV neonatally infected rats, we analyzed at different times postinfection the expression levels of growth-associated protein 43 and synaptophysin, two molecules involved in neuroplasticity processes. We found that BDV induced a progressive and marked decrease in the expression of these synaptic markers, which was followed by a significant loss of cortical neurons. Our findings suggest that BDV persistent infection interferes with neuroplasticity processes in specific cell populations. This, in turn, could affect the proper supply of growth factors and other molecules required for survival of selective neuronal populations within the cortex and limbic system structures.  (+info)

Expression and characterization of the Borna disease virus polymerase. (7/148)

Borna disease virus is the prototype of a new family, Bornaviridae, within the order Mononegavirales, that is characterized by nuclear transcription, splicing, low level replication, and neurotropism. The products of five open reading frames predicted from the genomic sequence have been confirmed; however, expression of the sixth, corresponding to the putative viral polymerase (L), has not been demonstrated. Here, we describe expression and characterization of a 190-kDa protein proposed to represent L. Expression of this protein from the third transcription unit of the viral genome is dependent on a splicing event that fuses a small upstream open reading frame in frame with the larger downstream continuous open reading frame. The protein is detected by serum antibodies from infected rats and is present in the nucleus, where it colocalizes with the phosphoprotein. L is also shown to be phosphorylated by cellular kinases and to interact with the viral phosphoprotein in coimmunoprecipitation studies. These findings are consistent with the identity of the 190-kDa protein as the viral polymerase and provide insights and describe reagents that will be useful for Bornavirus molecular biology and pathobiology.  (+info)

Isolation and characterization of a new subtype of Borna disease virus. (8/148)

Borna disease virus (BDV), the causative agent of severe meningoencephalitis in a wide variety of animal species, has been considered to be genetically invariable and to form a single type within the genus Bornavirus of the family Bornaviridae. BDV infections are of particular interest, because for the first time a virus infection appears to be linked to human psychiatric disorders. We now describe a new subtype of BDV isolated from a horse which was euthanatized due to severe, incurable neurological disease. The nucleotide sequence of this new strain, named No/98, differs from the reference strains by more than 15%, and the subtype is difficult to detect by standard reverse transcriptase PCR protocols. The nucleotide exchanges of the novel BDV isolate have surprisingly little effect on the primary structures of most viral proteins, with the notable exception of the X protein (p10), which is only 81% identical to its counterpart in reference strains. Our data indicate that the genome of BDV is far more variable than previously assumed and that naturally occurring subtypes may escape detection by currently used diagnostic assays.  (+info)

*Borna disease

Although Borna disease viruses 1 and 2 are mainly seen as the causative agent of Borna disease in horses and other animals, ... Borna disease is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease viruses 1 and 2 (BoDV-1/2 ... individuals may develop Borna disease, or may remain subclinical, possibly acting as a carrier of the virus. Borna diseases ... Borna disease in the horse gives rise to signs like: Unusual posture, gait and ear positions Movement Disturbances (principally ...

*Borna disease virus

Borna disease was first described in 1885 as "heated head disease" of cavalry horses in 1885 in the town of Borna, Germany. ... The Borna disease viruses (BoDV-1 and BoDV-2) are members of the species Mammalian 1 bornavirus, which cause Borna disease in ... Perez M, Watanabe M, Whitt MA, de la Torre JC (August 2001). "N-terminal domain of Borna disease virus G (p56) protein is ... Wolff T, Pfleger R, Wehner T, Reinhardt J, Richt JA (April 2000). "A short leucine-rich sequence in the Borna disease virus p10 ...

*Bicolored shrew

... white-toothed shrew is a natural reservoir species for the Borna disease virus which is the causative agent of Borna disease, a ... Emerging Infectious Diseases. 12 (4): 675-677. doi:10.3201/eid1204.051418. Kamhieh S, Flower RL (June 2006). "Borna disease ... Rott, R.; Herzog, S.; Bechter, K.; Frese, K. (1991). "Borna disease, a possible hazard for man?". Archives of Virology. 118 (3- ... "Shrews as Reservoir Hosts of Borna Disease Virus". ...

*MiR-122

"Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells". Antiviral Res. 87 (2): 249-56 ... Biomarkers in Liver Disease. V. B. Patel and V. R. Preedy. Dordrecht, Springer Netherlands: ISBN 978-94-007-7675-3, page 193- ... This change is noted before increased amino-transferase activity, making it a early indicator of liver disease and ... and Chemical-Related Hepatic Diseases". Clin Chem. 56 (12): 1830-8. doi:10.1373/clinchem.2010.147850. PMID 20930130. Xu H, He ...

*Infections associated with diseases

Bode, L; Ludwig, H (2003). "Borna disease virus infection, a human mental-health risk". Clinical Microbiology Reviews. 16 (3): ... Diseases may also be multifactorial, requiring multiple factors to induce disease. For example: in a murine model, Crohn's ... The history of infection and disease were observed in the 1800s and related to the one of the tick-borne diseases, Rocky ... "The Role of Chronic Disease in Higher Health Costs and Lower U.S. Economic Growth". Almanac of Chronic Disease (PDF). ...

*Bornaviridae

Diseases associated with bornaviruses include Borna disease, a fatal neurologic disease of mammals restricted to central Europe ... and proventricular dilatation disease in birds. Borna disease was first identified in 1926 and its genome was isolated in 1990 ... "Borna". Veterinary Microbiology and microbial disease, 2nd edition, P J Quinn et al. Wiley-Blackwell Hoffmann, Bernd; Tappe, ... The viral family is named after the city of Borna in Saxony, Germany, which is where a large number of animals were lost to the ...

*Animal model of autism

Pletnikov, M. V.; Moran, T. H.; Carbone, K. M. (2002). "Borna disease virus infection of the neonatal rat: Developmental brain ... Much research has been done into the use of a rat model to show how Borna virus infection, exposure to valproic acid in utero, ... Centers for Disease Control (2008-02-08). "Mercury and vaccines (thimerosal)". Retrieved 2011-08-01. Crawley, J. N. (2012). " ... Klauck, S. M.; Poustka, A. (2006). "Animal models of autism". Drug Discovery Today: Disease Models. 3 (4): 313-318. doi:10.1016 ...

*Influenza

Thogoto and Borna disease viruses". Virus Res. 95 (1-2): 3-12. doi:10.1016/S0168-1702(03)00159-X. PMID 12921991. Kash, J; ... Centers for Disease Control and Prevention: "QUESTIONS & ANSWERS: Novel H1N1 Flu (Swine Flu) and You" Archived 4 March 2010 at ... Centers for Disease Control and Prevention. Lab Diagnosis of Influenza. Archived 3 May 2009 at the Wayback Machine. Retrieved 1 ... Centers for Disease Control and Prevention (CDC) (2006). "High levels of adamantane resistance among influenza A (H3N2) viruses ...

*Avian bornavirus

In general these viruses show only about 65% sequence identity with mammalian Borna disease virus 1 (BoDV-1). The overall ... as the cause of proventricular dilatation disease (PDD), a disease of pet parrots. While a report of research using a 'positive ... Use of Avian Bornavirus Isolates to Induce Proventricular Dilatation Disease in Conures. Emerging Infectious Diseases, 16: 473- ... Gancz and his colleagues showed that inoculation of parrot bornavirus 4-infected brain tissue will also induce typical disease ...

*Perforin

Nöske K, Bilzer T, Planz O, Stitz L (1998). "Virus-Specific CD4+ T Cells Eliminate Borna Disease Virus from the Brain via ...

*Mady Hornig

She directs the clinical core of an international investigation of the role of Borna disease virus in human mental illness and ... based on neonatal rat infection with Borna disease virus. In 2004, Hornig published a controversial paper concluding that, in a ... In the 1990s, Hornig investigated the potential link between the Borna virus and depression in humans. Hornig has been ... in the early stages of the disease had higher levels of cytokines than people without CFS. In the 1990s, Hornig helped to ...

*Causes of autism

Laboratory rats infected with Borna disease virus show some symptoms similar to those of autism but blood studies of autistic ... or whether they are secondary to the disease processes. As autoantibodies are found in diseases other than ASD, and are not ... Because diseases such as measles can cause severe disabilities and death, the risk of death or disability for an unvaccinated ... Ashwood P, Van de Water J. Is autism an autoimmune disease? Autoimmun Rev. 2004;3(7-8):557-62. doi:10.1016/j.autrev.2004.07.036 ...

*Causes of schizophrenia

Polio, measles, varicella-zoster, rubella, herpes simplex virus type 2, maternal genital infections, Borna disease virus, and ... It is a pathogenic theory of disease in which it is thought that a proximal cause of certain cases of schizophrenia is the ... An updated meta-analysis on CNVs for schizophenia published in 2015 expanded the number of CNVs indicated in the disease, which ... In 2013 this dataset was expanded to identify in total 13 candidate loci for the disease, now also implicating calcium ...

*Negative-sense single-stranded RNA virus

Order Mononegavirales Family Bornaviridae - Borna disease virus Family Filoviridae - includes Ebola virus, Marburg virus Family ... The families consisting of nonsegmented genomes include Rhabdo-, Paramyxo-, Filo- and Borna-. Orthomyxo-, Bunya-, Arenaviridae ... Impact on Human Disease and Therapeutic Intervention". Annual Review of Medicine. 66 (1): 311-328. doi:10.1146/annurev-med- ...

*List of MeSH codes (B04)

... borna disease virus MeSH B04.820.455.300 --- filoviridae MeSH B04.820.455.300.200 --- ebola-like viruses MeSH B04.820.455.300. ... borna disease virus MeSH B04.909.777.455.300 --- filoviridae MeSH B04.909.777.455.300.200 --- ebola-like viruses MeSH B04.909. ... aleutian mink disease virus MeSH B04.280.580.650.600.325 --- feline panleukopenia virus MeSH B04.280.580.650.600.550 --- mice ... lumpy skin disease virus MeSH B04.280.650.160.500 --- leporipoxvirus MeSH B04.280.650.160.500.250 --- fibroma virus, rabbit ...

*RNA virus

Order Mononegavirales Family Bornaviridae - includes Borna disease virus Family Filoviridae - includes Ebola virus, Marburg ... This is one reason why it is difficult to make effective vaccines to prevent diseases caused by RNA viruses. Retroviruses also ... Notable human retroviruses include HIV-1 and HIV-2, the cause of the disease AIDS. Another term for RNA viruses that explicitly ... This nucleic acid is usually single-stranded RNA (ssRNA) but may be double-stranded RNA (dsRNA). Notable human diseases caused ...

*List of MeSH codes (C02)

... borna disease MeSH C02.782.580.250 --- filoviridae infections MeSH C02.782.580.250.400 --- hemorrhagic fever, ebola MeSH ... swine vesicular disease MeSH C02.782.687.484 --- foot-and-mouth disease MeSH C02.782.791.142 --- african horse sickness MeSH ... border disease MeSH C02.782.350.675.106 --- bovine virus diarrhea-mucosal disease MeSH C02.782.350.675.200 --- classical swine ... kyasanur forest disease MeSH C02.782.417.505 --- lassa fever MeSH C02.782.417.560 --- marburg virus disease MeSH C02.782. ...

*Borna

... a family of viruses associated with Borna disease Borna disease virus Borna language (Democratic Republic of the Congo), a ... Borna may refer to: Borna, Leipzig, a town in Saxony, Germany Borna, a subdivision of Bahretal municipality, Saxony, German ... a Croatian masculine given name Bertin Borna (1930-2007), a Beninese politician Borna disease, an infectious neurological ... Borna Dam, an earthfill dam on Borna river near Ambejogai, Beed district, Maharashtra, India Borna (duke), the Duke of Dalmatia ...

*Proventricular dilatation disease

Novel borna virus in psittacine birds with proventricular dilatation disease. Emerging infectious diseases 14(12), 1883-6.e ... Proventricular dilatation disease (PDD) is a disease affecting psittacines (parrots). It was first recognized and described in ... The clinical presentation of this disease varies with the individual as well as in severity of those symptoms. Often the ... Kristen Bole (2008-07-29). "UCSF researchers identify virus behind mysterious parrot disease". UCSF News Office. Retrieved 2008 ...

*Ljudevit

Borna moved with Ljudevit's father-in-law Dragomuž and their forces from the south-west. At the heat of the Battle of Kupa, his ... The Franks eventually retreated from his lands, with their ranks thinned by disease which the northern forces caught in the ... Borna was too weak, so the Dalmatians defended themselves through sneaky tactics and used attrition as their best ally to ... Borna escaped from the battlefield with the help of his bodyguards. Ljudevit seized the opportunity and breached into and ...

*Shisei Kuwabara

Kuwabara was born - as Fumiaki Kuwabara (桑原史成, Kuwabara Fumiaki) - in the village of Kibe (now part of Tsuwano), Shimane ... Kuwabara's photographs of Minamata were shown in his first solo exhibition, Minamata-byō (Minamata disease), at the Fuji Photo ... Shashin-kiroku Minamata-byō 1960-1970 (写真記録 水俣病 1960-1970, "Documentary: Minamata disease"). Tokyo: Asahi Shinbun, 1970. ...

*Virus

... and chronic wasting disease in deer; in humans, prionic diseases include Kuru, Creutzfeldt-Jakob disease, and Gerstmann- ... Chen C, Chiu Y, Wei F, Koong F, Liu H, Shaw C, Hwu H, Hsiao K. High seroprevalence of Borna virus infection in schizophrenic ... Diseases such as foot-and-mouth disease and bluetongue are caused by viruses. Companion animals such as cats, dogs, and horses ... Many serious diseases such as Ebola virus disease, AIDS, avian influenza, and SARS are caused by viruses. The relative ability ...

*Horatio Clarence Hocken

Michael Hanlon, "Out of the darkness The Evening Star is born --- A group of jilted printers had enough and created 'a paper ... His reforms saw the death rate from communicable disease drop from 114 per 100,000 to 27 per 100,000. Hocken also supported the ...

*Vesicular transport adaptor protein

Small SA, Petsko GA (March 2015). "Retromer in Alzheimer disease, Parkinson disease and other neurological disorders". Nature ... Hirst J, Borner GH, Edgar J, Hein MY, Mann M, Buchholz F, Antrobus R, Robinson MS (2013). "Interaction between AP-5 and the ... COPI is linked to an autoimmune disease. COPII is linked to cranio-lenticulo-sutural dysplasia. One of the GGA proteins may be ... Adaptor diseases have been reviewed. AP-2/CCVs are involved in autosomal recessive hypercholesterolemia through the associated ...

*Tarangire Ecosystem

Around 1900 they suffered pleuro-pneumonia and small pox diseases that killed many. At the same time the outbreak of the ... Borner, Markus (1985-04-01). "The increasing isolation of Tarangire National Park". Oryx. 19 (2): 91-96. doi:10.1017/ ...

*List of Plasmodium species

It is suspected that this disease was introduced by the Romans sometime before 400 AD. It seems likely that it remained endemic ... 1869-1886 Borner J, Pick C, Thiede J, Kolawole OM, Kingsley MT, Schulze J, Cottontail VM, Wellinghausen N, Schmidt-Chanasit J, ... The paleogeography of mosquito-borne disease. Biol J Linn Soc Lond 19:26 Bennett, GF (1993). "Phylogenetic distribution and ...
TY - JOUR. T1 - Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection. AU - Bautista, Jan R.. AU - Schwartz, Gary J.. AU - De La Torre, Juan Carlos. AU - Moran, Timothy H. AU - Carbone, Kathryn M.. PY - 1994. Y1 - 1994. N2 - Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), with no signs of encephalitis or Borna disease. We measured body weight, body length, taste preferences, and spontaneous locomotor activity over a 4-month period in PTI-NB and control rats. PTI-NB rats had decreased weight and length but not detectable disturbances in growth hormone and insulin-like growth factor-1 biosynthesis as compared to control rats. In single bottle taste acceptance tests, PTI-NB rats did not differ from controls and drank normal amounts of all solutions. When offered a choice of solutions in two-bottle taste preference tests, PTI-NB rats exhibited a normal preference for saccharin and a ...
Characterization of the Borna disease virus phosphoprotein, p23.: Borna disease virus infection is diagnosed by the presence of serum antibodies reactive with t
Borna disease virus (BDV) is a non-segmented, negative-strand RNA virus that replicates and transcribes its genome in the nucleus of infected cells. It uses the cellular splicing machinery to generate a set of alternatively spliced mRNAs from the 2.8 and 7.1 kb primary transcripts, each harbouring two introns. To determine whether splicing of these transcripts is regulated by viral factors, the extent of splicing was studied in infected cells and COS-7 cells transiently transfected with plasmids encoding the 2.8 kb RNA of BDV. Unspliced RNA was found to be the most abundant RNA species in infected cells, whereas viral transcripts lacking both introns were only found in minute amounts. In sharp contrast, plasmid-derived 2.8 kb RNA was predominantly intron 1-spliced and double-spliced. Co-expression of the BDV proteins P, N and X did not influence splicing of plasmid-expressed 2.8 kb RNA. Furthermore, the splicing pattern did not change when the 2.8 kb RNA was expressed in BDV-infected cells. Based on
Borna disease virus, a newly classified nonsegmented negative-strand RNA virus with international distribution, infects a broad range of warm-blooded animals from birds to primates. Infection causes movement and behavioral disturbances reminiscent of some neuropsychiatric syndromes. The virus has not been clearly linked to any human disease; however, an association between infection with the virus and selected neuropsychiatric disorders has been suggested. We reviewed recent advances in Borna disease virus research, focusing on evidence of infection in humans ...
Read "Neuron-glia interactions in the rat retina infected by Borna disease virus, Archives of Virology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Previous studies have shown that schizophrenics and those with mood disorders have higher levels of Borna Disease Virus (BDV) RNA and anti-BDV antibodies. The researchers in this study aimed to determine the relationship between infection with Borna Disease Virus (BDV) and schizophrenia and other mood disorders, with respect to symptom subtypes and clinical time course. 32 schizophrenics and 33 mood disorder patients were tested against 25 controls. Serum was collected from the patients, and Western Blots were used to detect anti-BDV-p10 (nucleoprotein fusion proteins) antibodies. The study found a statistically significant correlation with the levels of anti-BDV antibodies and the mood disorder patients, but the study found no significant correlations in the case with schizophrenia. A significant relationship was found, however, between BDV antibody levels and the type of schizophrenia ("productive" or positive, against "deficit" or negative). The study also found a similar relationship between ...
Summary The effect of interferon (IFN) on infection and maintenance of persistent infection of Borna disease (BD) virus in cell cultures was investigated. Acutely BD virus-infected primary rabbit brain and rat lung cells produced significant levels of interferon detectable 3 days post-infection in the culture supernatants. Rat brain and rat lung cells persistently infected with BD virus produced only moderate levels of IFN over a long period. In contrast, persistently infected Madin-Darby canine kidney (MDCK) cells did not produce detectable amounts of IFN. Exogenous homologous IFN completely inhibited the expression of BD virus antigen in acutely infected rabbit brain cells, when added during the first 24 h after infection. IFN added later (2 to 6 days post-infection) reduced virus titres to different degrees depending on the onset of treatment. However, IFN added to persistently infected rat lung cells did not appear to influence the degree or quality of BD virus antigen expression or the
Numerous species of mammals are susceptible to this virus. It is of clinical relevance particularly in horses, in cats (where the disease is also called "staggering disease") and in sheep. The virus has a strong neurotropism and triggers non-purulent meningoencephalitis, associated with anorexia, apathy, somnolence and multiple neuronal dysfunctions. Animals suffering from Borna disease develop motor and behavioural disorders. In horses and sheep, in addition to the symptoms listed above, a lowered head posture, separation from the herd, empty chewing and salivation have been described and, at a later stage, recumbency and flailing movements. Cats frequently suffer from hind-leg ataxia and lumbosacral pain.. There is often little or no immune response, which makes it difficult to diagnose by testing for antibodies. The incubation period is unknown. The progression of a clinically manifested infection is lethal (duration of the disease usually 1 - 3 weeks).. Clinically inapparent infections are ...
Borna disease virus replication in organotypic hippocampal slice cultures from rats results in selective damage of dentate granule cells. J Virol 79: 11716-23. (#: these authors were co-senior authors) J. Schwenk, N. Harmel, G. Zolles, W. Bildl, A. Kulik, B. Heimrich, O. Chisaka, P. Jonas, U. Schulte, B. Fakler, N. Klöcker (2009 ...
Borna disease virus replication in organotypic hippocampal slice cultures from rats results in selective damage of dentate granule cells. J Virol 79: 11716-23. (#: these authors were co-senior authors) H. Brinks, S. Conrad, J. Vogt, J. Oldekamp, A. Sierra, L. Deitinghoff, I. Bechmann, G. Alvarez-Bolado, B. Heimrich#, P.P. Monnier#, B.K. Müller#, and T. Skutella# (2004 ...
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Borna disease virus (BDV) The only species in the genus Bornavirus. Named after a town in Saxony where the first major outbreak in horses occurred. Negative-strand RNA virus which produces persistent infection in a variety of experimental …. The London encyclopaedia, or, Universal dictionary of science, art, literature, and practical mechanics, by the orig. ed. of the Encyclopaedia metropolitana [T. Curtis]. (1839). by Thomas Curtis (of Grove house sch, Islington ...
Serological incidence of Gumboro disease virus infection in chicken flocks in Cairo district. , Amer, M. M.,.Bastami M. A., D.G.khilfa, and Hamouda A. S. , Assut. Vet. Med. J., , Volume 17, Issue 33, p. 211-216., (1986 ...
Borna disease virus-1 (BoDV-1) was recently discovered as cause of severe and often fatal encephalitis in humans. BoDV-1 is known to cause neurological disease in horses and sheep mainly in South and Central Germany. The virus is maintained in bicolored white-toothed shrews (Crocidura leucodon). The incidence of infection and risk factors in humans are completely unresolved. Veterinarians may be disproportionally BoDV-1-exposed through contact to animals not recognized to be BoDV-1 infected. We conducted three serosurveys predominantly in endemic areas of South Germany for the presence of BoDV-1-reactive antibodies. Anonymized residual samples from two serosurveys of veterinarians (n = 736) with interview data on exposures and one serosurvey among blood donors (n = 373) were screened with an indirect immunofluorescence antibody test, followed by a newly developed immunoblot as confirmatory assay. One serum from a 55-59-year-old veterinarian who worked in an animal practice and as a meat ...
The bicoloured shrew (Crocidura leucodon) lives exclusively in Central Europe, the region where the Borna disease occurs. This area is mostly within Germany, but also includes the eastern part of Switzerland and Vorarlberg in western Austria. Virologist Nowotny explains: "The distribution of bicoloured shrews remains fairly constant because the animals stay within their habitats. They do not like to move around." In fact, the number of incidents of Borna disease has actually declined in the last few years. There are currently about 100 cases per year.. Genetics reveals transmission mechanism. A genetic analysis of viruses taken from bicoloured shrews and horses provides further proof that the bicoloured shrew acts as a pathogen reservoir. The viral strains found in the shrews correspond exactly with the strains from sick horses in the same region. This supports the assumption that the virus sub-types develop in a particular region over the course of centuries in bicoloured shrews and do not ...
Borna disease virus (BDV) The only species in the genus Bornavirus. Named after a town in Saxony where the first major outbreak in horses occurred. Negative-strand RNA virus which produces persistent infection in a variety of experimental …. The London encyclopaedia, or, Universal dictionary of science, art, literature, and practical mechanics, by the orig. ed. of the Encyclopaedia metropolitana [T. Curtis]. (1839). by Thomas Curtis (of Grove house sch, Islington ...
Mareks disease (MD), a herpesvirus-induced lymphomatous disease in chickens, has attracted the interest of immunologists since MD virus (MDV) was isolated in 1968 and vaccines became available shortl
Bornaviridae is a family of viruses in the order Mononegavirales. Horses, sheep, cattle, rodents, birds, reptiles, and humans serve as natural hosts. Currently, 16 viruses are assigned to eight species included in one genus in this family. Diseases associated with bornaviruses include Borna disease, a fatal neurologic disease of mammals restricted to central Europe; and proventricular dilatation disease in birds. Borna disease was first identified in 1926 and its genome was isolated in 1990. The viral family is named after the city of Borna in Saxony, Germany, which is where a large number of animals were lost to the sporadic encephalopathy caused by the viral disease. Table legend: "*" denotes type species. Bornavirions are enveloped, with spherical geometries. The diameter is around 70 to 130 nm. Genomes are linear, around 8.9kb in length. The genome codes for 9 proteins. Below are a few of the essential proteins of Bornaviridae that have been characterized. Viral replication is nuclear. Entry ...
The hematological lesions consequent upon velogenic Newcastle disease virus (NDV) infection were investigated in 6-week-old ducks and chickens. Following intramuscular inoculation, the results indicated significantly lower (p
Foot-and-mouth disease virus (FMDV) is a single stranded RNA virus in the picornavirus family. It is the causative agent of foot-and-mouth disease, globally the most important a�iction of cloven hoofed animals. The FMDV genome has several features that are not found amongst other viruses within the Picornaviridae. These include a large 50 untranslated region (UTR), almost twice the length of that found in enteroviruses, containing highly structured RNA elements unique to FMDV, such as the S-fragment and several tandemly repeated pseudoknots. Unique aspects are also found within the coding region, where FMDV is the only picornavirus reported to contain multiple copies of the 3B gene. The reasons behind possession of these unusual deviations from the dogma of the picornaviral genome is so far unknown and therefore poses an attractive target for further research. The S-fragment is a predicted 360 nucleotide stem-loop at the 50 end of the FMDV genome. The better studied poliovirus (PV) has a well ...
Jembrana disease virus (JDV) is an acute lentiviral infection of Bali cattle in Indonesia. Data generated during a series of cattle infection experiments was examined and significant differences were identified in the mean plasma viral load on the first and second days of the febrile response in cattle infected with JDVTAB/87 compared to those infected with JDVPUL/01. The peak and total viral loads ,= 106 genome copies/ml during the acute stage of the disease were significantly higher in JDVTAB/87 infected cattle. JDVPUL/01 infected cattle developed peak rectal temperatures earlier than the JDVTAB/87 cattle but there were no differences in the duration of the febrile responses observed for the 2 groups of animals. The plasma viremia was above 106 genome copies/ml for almost 3 days longer in JDVTAB/87 compared to JDVPUL/01 infected cattle. Atypical responses to infection occurred in approximately 15% of experimentally infected animals, characterized by reduced viral loads, lower or absent febrile ...
Jembrana disease was reported initially in Bali cattle (Bos javanicus) on Bali island in 1964 and the causative agent was subsequently identified as a bovine lentivirus and designated Jembrana disease virus (JDV). This atypical lentivirus causes an acutely pathogenic disease that is associated with clinical signs and pathological lesions attributable to a disease primarily affecting the lymphoid system. Based on the intense proliferation of cells in the parafollicular (T-cell) areas of lymphoid tissue it has been assumed that the cellular tropism of the virus was for T-cells.. An initial investigation of the pathological changes following JDV infection provided morphological evidence that JDV infection occurred not in T-cells but probably in centroblast-like cells containing IgG and presumably of B-cell lineage. The identity of the infected cells was confirmed by double immunofluorescence labelling techniques as being IgG-containing CD79α+ cells, indicating that the virus replicated in mature ...
Foot-and-mouth disease virus (FMDV) can cause transplacental infection and death in fetal lambs. This study investigates the pathogenesis of FMDV infection in ovine fetuses using in-situ hybridization (ISH) to detect viral transcripts in tissue and real-time reverse transcriptase polymerase chain reaction (RT-PCR) assays to quantify the fetal cytokine response to infection. FMDV ribonucleic acid (RNA) was localized mainly to the heart and skeletal muscles of fetuses and was only occasionally expressed in the lingual epithelium, demonstrating that FMDV has a different tissue tropism in the fetus compared with that in adult sheep. There was early expression of genes encoding anti-viral cytokines (IFN-alpha and IFN-beta) in fetuses at 2 and 4 days post-infection (dpi), followed by a marked rise in the transcription of pro-inflammatory cytokine genes (IFN-gamma, TNF-alpha and IL-1 alpha) from 7 to 18 dpi, particularly in the heart. The degree of cytokine mRNA expression correlated with fetal ...
Conventional and nude mice inoculated with syngeneic or allogenic tumor cells developed a rapid rise in serum interferon (IF) levels, peaking within 24 h. Within the same period, natural killer (NK) activity was readily boosted in the spleen. Both activities usually declined at 3 d. Cells that lacked the ability to augment NK activity also failed to induce detectable levels of IF. The boosting of IF and NK functions did not appear to be a result of contamination of the tumor lines by viruses because inoculation of several type C viruses into normal mice had no effect, and other viruses, like lymphocytic choriomeningitis virus and influenza, elevated IF and NK levels with a significantly later kinetics, peaking 3-4 d. The IF induced by tumor cells was heat and acid labile, species specific, and appeared to be in the type II class, although it was susceptible to antisera against Newcastle disease virus-induced IF. These data suggest that an early, nonthymus-dependent consequence of tumor-cell ...
Assessing the potential spread and maintenance of foot-and-mouth disease virus infection in wild ungulates: general principles and application to a specific scenario in Thrace. / Dhollander, S.; Belsham, Graham; Lange, M.; Willgert, K.; Alexandrov, T.; Chondrokouki, E.; Depner, K.; Khomenko, S.; Özyörük, F.; Salman, M.; Thulke, H.-H.; Bøtner, Anette.. In: Transboundary and Emerging Diseases, Vol. 63, No. 2, 2016, p. 165-174.. Publication: Research - peer-review › Journal article - Annual report year: 2014 ...
Citation: Zhang, H., Xie, Q., Chang, S., Ernst, C.W., Song, J. 2014. Preliminary Analysis of MicroRNA Transcriptome Altered by Vaccine and Mareks Disease Virus in Chickens. Plant and Animal Genome Conference. Paper No. 9952. Available: https://pag.confex.com/pag/xxii/webprogram/Paper9952.html. Interpretive Summary: Technical Abstract: MicroRNAs are a class of small, non-coding RNAs that regulate gene expression at the post-transcriptional level and play important roles in many biological processes such as development, cell signaling and immune response. Mature miRNAs are about 22 nucleotides in length. Reportedly, the growth of various tumors, including cancers, is mediated by dysfunctional regulation by miRNAs, and differential expression of miRNA is associated with virus infection and tumorigenesis. This study was aimed to explore the microRNA transcriptome and to profile microRNA expression in response to vaccination or Mareks disease virus infection in two highly inbred lines of chickens ...

Authentic Borna disease virus transcripts are spliced less efficiently than cDNA-derived viral RNAs - Academic CommonsAuthentic Borna disease virus transcripts are spliced less efficiently than cDNA-derived viral RNAs - Academic Commons

Borna disease virus (BDV) is a non-segmented, negative-strand RNA virus that replicates and transcribes its genome in the ... Authentic Borna disease virus transcripts are spliced less efficiently than cDNA-derived viral RNAs. Author(s):. Jehle, ... Borna disease virus (BDV) is a non-segmented, negative-strand RNA virus that replicates and transcribes its genome in the ... Christian Jehle, W. Ian Lipkin, Peter Staeheli, Rosa M. Marion, Martin Schwemmle, 2000, Authentic Borna disease virus ...
more infohttps://academiccommons.columbia.edu/catalog/ac%3A130197

Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection<...Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection<...

Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection. Brain Research Bulletin. ... Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection. / Bautista, Jan R.; Schwartz ... Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), with ... N2 - Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), ...
more infohttps://jhu.pure.elsevier.com/en/publications/early-and-persistent-abnormalities-in-rats-with-neonatally-acquir-3

Characterization of the Borna disease virus phosphoprotein, p2...Characterization of the Borna disease virus phosphoprotein, p2...

Borna disease virus infection is diagnosed by the presence of serum antibodies reactive with t ... Characterization of the Borna disease virus phosphoprotein, p23.: ... Borna disease virus infection is diagnosed by the presence of serum antibodies reactive with the major viral proteins, p40 and ...
more infohttps://www.mysciencework.com/publication/show/characterization-of-the-borna-disease-virus-phosphoprotein-p23

PublicationsPublications

CD8 T cells require gamma interferon to clear Borna disease virus from the brain and prevent immune system-mediated neuronal ... Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a ... A new recombinant Orf virus (ORFV, Parapoxvirus) protects rabbits against lethal infection with rabbit hemorrhagic disease ...
more infohttp://www.immunology-tuebingen.de/groups/ralf-amann/publications.html

Borna disease - WikipediaBorna disease - Wikipedia

Although Borna disease viruses 1 and 2 are mainly seen as the causative agent of Borna disease in horses and other animals, ... Borna disease is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease viruses 1 and 2 (BoDV-1/2 ... individuals may develop Borna disease, or may remain subclinical, possibly acting as a carrier of the virus. Borna diseases ... Borna disease in the horse gives rise to signs like: Unusual posture, gait and ear positions Movement Disturbances (principally ...
more infohttps://en.wikipedia.org/wiki/Borna_disease

Borna disease virus - WikipediaBorna disease virus - Wikipedia

Borna disease was first described in 1885 as "heated head disease" of cavalry horses in 1885 in the town of Borna, Germany. ... The Borna disease viruses (BoDV-1 and BoDV-2) are members of the species Mammalian 1 bornavirus, which cause Borna disease in ... Perez M, Watanabe M, Whitt MA, de la Torre JC (August 2001). "N-terminal domain of Borna disease virus G (p56) protein is ... Wolff T, Pfleger R, Wehner T, Reinhardt J, Richt JA (April 2000). "A short leucine-rich sequence in the Borna disease virus p10 ...
more infohttps://en.wikipedia.org/wiki/Borna_disease_virus

Borna Disease | The Pig SiteBorna Disease | The Pig Site

Borna disease, is caused by a virus which damages the nervous system. It has been known in horses in Germany and surrounding ...
more infohttps://thepigsite.com/disease-guide/borna-disease

Borna disease - definition of borna disease by The Free DictionaryBorna disease - definition of borna disease by The Free Dictionary

borna disease synonyms, borna disease pronunciation, borna disease translation, English dictionary definition of borna disease ... n vet science a viral disease of mammals, esp horses, caused by a member of the Flaviviridae and characterized by the ... borna disease. Also found in: Medical, Wikipedia. borna disease. (ˈbɔːnə) n. (Veterinary Science) vet science a viral disease ... Borna disease - definition of borna disease by The Free Dictionary https://www.thefreedictionary.com/borna+disease ...
more infohttp://www.thefreedictionary.com/Borna+disease

N (Borna disease virus 1) | Gene Target - PubChemN (Borna disease virus 1) | Gene Target - PubChem

Borna disease virus 1). Find diseases associated with this biological target and compounds tested against it in bioassay ...
more infohttps://pubchem.ncbi.nlm.nih.gov/target/gene/N

ASMscience | Borna Disease Virus: SpaASMscience | Borna Disease Virus: Spa

... with specific interests in virus infection and human neuropsychiatric diseases. The establishment of sensitive immunoassays ... The study of Borna disease virus (BDV) and BD has broad impact on diverse areas of biology and medicine, notably on molecular ... Home / Books / Borna Disease Virus and Its Role in Neurobehavior... / Chapter 1 : Borna Disease Virus: Spanning a Century of ... Borna Disease Virus: Spanning a Century of Science, p 1-21. In Carbone K (ed), Borna Disease Virus and Its Role in ...
more infohttp://www.asmscience.org/content/book/10.1128/9781555817909.chap1

Borna Disease - Volume 3, Number 2-June 1997 - Emerging Infectious Diseases journal - CDCBorna Disease - Volume 3, Number 2-June 1997 - Emerging Infectious Diseases journal - CDC

We reviewed recent advances in Borna disease virus research, focusing on evidence of infection in humans. ... The virus has not been clearly linked to any human disease; however, an association between infection with the virus and ... Borna disease virus, a newly classified nonsegmented negative-strand RNA virus with international distribution, infects a broad ... Serum immunoreactivity to Borna disease virus in various diseases *Table 2. Borna disease virus nucleic acid in patients with ...
more infohttp://wwwnc.cdc.gov/eid/article/3/2/97-0205_article

Table 2 - Borna Disease - Volume 3, Number 2-June 1997 - Emerging Infectious Diseases journal - CDCTable 2 - Borna Disease - Volume 3, Number 2-June 1997 - Emerging Infectious Diseases journal - CDC

We reviewed recent advances in Borna disease virus research, focusing on evidence of infection in humans. ... The virus has not been clearly linked to any human disease; however, an association between infection with the virus and ... Borna disease virus, a newly classified nonsegmented negative-strand RNA virus with international distribution, infects a broad ... Human infections with Borna disease virus: seroprevalence in patients with chronic diseases and healthy individuals. J Med ...
more infohttps://wwwnc.cdc.gov/eid/article/3/2/97-0205-t2

Borna Disease - Managing Pig Health and Treating Pig Dieases on ThePigSite.com - The Pig SiteBorna Disease - Managing Pig Health and Treating Pig Dieases on ThePigSite.com - The Pig Site

Borna disease, is caused by a virus which damages the nervous system. It has been known in horses in Germany and surrounding ... Borna Disease. (536) Borna disease, is caused by a virus which damages the nervous system. It has been known in horses in ...
more infohttp://www.thepigsite.com/pighealth/article/443/borna-disease/

Persistent Borna disease virus infections: the natural disease and
animal modelsPersistent Borna disease virus infections: the natural disease and animal models

Besides its significance for the practitioner, Boma disease virus infection remains to be unique as a disease model: it allows ... Abstract: Boma Disease virus grows without any cytopathic effect in many cell lines (including those from man). It comprises an ... Histopathologically, Boma disease often goes along with a non-purulent inflammation of the brain and the spinal cord. Most ... The diagnosis of Boma disease is established intra vitam on the basis of the clinical symptoms and the presence of antibodies ...
more infohttps://scialert.net/asci/ascidetail.php?doi=ijv.2005.1.1&kw=

Persistent Borna Disease Virus infection changes expression and function of astroglial gap junctions in vivo and in vitro.  -...Persistent Borna Disease Virus infection changes expression and function of astroglial gap junctions in vivo and in vitro. -...

Persistent Borna Disease Virus infection changes expression and function of astroglial gap junctions in vivo and in vitro.. ... Neonatal Borna Disease Virus (BDV) infection of the Lewis rat brain leads to dentate gyrus (DG) degeneration, underlying ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/18028885?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Borna DiseaseBorna Disease

ANSWER: It could be Borna Disease which has also been called: Sad Horse Disease Staggering Cat Disease Wobbly Possum Disease ... The disease, and its causative virus, are named after BORNA, a town in Germany, where it was first described in 1766, affecting ... I hear you also have a dynamite HOLISTIC HEALING SECRETS FOR HUMANS course, fifty files long? Heal any disease, prevent any ... Borna virus has been isolated from patients with mood disorders, and there is evidence of a new human virus infection possibly ...
more infohttp://www.masterjules.net/catstagger.htm

Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and...Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and...

One salient example is the X protein of Borna disease virus, which is expressed both at the mitochondria and in the nucleus. ... Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and ... Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and ...
more infohttps://www.sigmaaldrich.com/catalog/papers/26700735

Neuron-glia interactions in the rat retina infected by Borna disease virus, Archives of Virology | 10.1007/s007050050010 |...Neuron-glia interactions in the rat retina infected by Borna disease virus, Archives of Virology | 10.1007/s007050050010 |...

"Neuron-glia interactions in the rat retina infected by Borna disease virus, Archives of Virology" on DeepDyve, the largest ... Neuron-glia interactions in the rat retina infected by Borna disease virus. Kacza, J.; Vahlenkamp, T. W.; Enbergs, H.; Richt, J ... Neuron-glia interactions in the rat retina infected by Borna disease virus Kacza, J.; Vahlenkamp, T. W.; Enbergs, H.; Richt, J ... lp/springer_journal/neuron-glia-interactions-in-the-rat-retina-infected-by-borna-disease-5TtL5rNknO ...
more infohttps://www.deepdyve.com/lp/springer_journal/neuron-glia-interactions-in-the-rat-retina-infected-by-borna-disease-5TtL5rNknO

Welcome to CDC stacks | Borna disease. - 15386 | Emerging Infectious DiseasesWelcome to CDC stacks | Borna disease. - 15386 | Emerging Infectious Diseases

The geographic distribution and host range of Borna disease (BD), a fatal neurologic disease of horses and sheep, are larger ... Borna disease virus (BDV) is the causative agent of severe T-cell-mediated meningoencephalitis in horses, sheep, and other ... Borna disease virus, a newly classified nonsegmented negative-strand RNA virus with international distribution, infects a broad ... The etiologic agent, Borna disease virus (BDV), has been identified as an enveloped nonsegmented neg... ...
more infohttps://stacks.cdc.gov/view/cdc/15386

Experimental vertical transmission of Borna disease virus in the mouse, Archives of Virology | 10.1007/s00705-003-0120-y |...Experimental vertical transmission of Borna disease virus in the mouse, Archives of Virology | 10.1007/s00705-003-0120-y |...

"Experimental vertical transmission of Borna disease virus in the mouse, Archives of Virology" on DeepDyve, the largest online ... Experimental vertical transmission of Borna disease virus in the mouse. Experimental vertical transmission of Borna disease ... Summary. We demonstrated the experimental vertical transmission of Borna. disease virus (BDV) in pregnant BALB/c mice. Giessen ... Experimental vertical transmission of Borna disease virus in the mouse. Okamoto, M.; Hagiwara, K.; Kamitani, W.; Sako, T.; ...
more infohttps://www.deepdyve.com/lp/springer_journal/experimental-vertical-transmission-of-borna-disease-virus-in-the-mouse-1ndE4BTFsF

ASMscience | Borna Disease Virus MoleASMscience | Borna Disease Virus Mole

BDV infection produces a range of phenotypic disease expression. BDV has a non-segmented, negative-stranded (NNS) RNA genome. ... Borna disease virus (BDV) infectivity and RNA have been detected in bodily secretions and excretions, suggesting that BDV can ... Natural and experimental Borna disease in animals, p. 17- 30. In H. Koprowski, and W. I. Lipkin (ed.), Borna Disease. Springer- ... Borna disease-neuropathology and pathogenesis, p. 39- 74. In H. Koprowski, and W. I. Lipkin (ed.) , Borna Disease Virus. ...
more infohttps://www.asmscience.org/content/book/10.1128/9781555817909.chap2

Borna Disease in a Free-Ranging Lynx (Lynx lynx) - MyScienceWo...Borna Disease in a Free-Ranging Lynx (Lynx lynx) - MyScienceWo...

Borna Disease in a Free-Ranging Lynx (Lynx lynx): A free-ranging lynx (Lynx lynx) was shot because of its abnormal behavior. ... Borna Disease in a Free-Ranging Lynx (Lynx lynx). Authors * M.-P. Degiorgis ... In situ hybridization, immunohistochemistry, and reverse transcriptase PCR analysis showed the presence of Borna disease virus ... To our knowledge, this is the first confirmed case of Borna disease in a large felid. ...
more infohttps://www.mysciencework.com/publication/show/borna-disease-in-a-free-ranging-lynx-lynx-lynx

Get PDF - Cell-to-cell spread of Borna disease virus proceeds in the absence of the virus primary receptor and furin-mediated...Get PDF - Cell-to-cell spread of Borna disease virus proceeds in the absence of the virus primary receptor and furin-mediated...

Cell-to-cell spread of Borna disease virus proceeds in the absence of the virus primary receptor and furin-mediated processing ... Borna disease virus induced meningoencephalomyelitis caused by a virus specific cd4 positive t cell mediated immune reaction. ... N-terminal domain of Borna disease virus G (p56) protein is sufficient for virus receptor recognition and cell entry. Journal ... Borna disease virus induces acute fatal neurological disorders in neonatal gerbils without virus- and immune-mediated cell ...
more infohttps://eurekamag.com/research/015/225/015225186.php

Borna disease in cattle (consensus report)]. - Semantic ScholarBorna disease in cattle (consensus report)]. - Semantic Scholar

... prevention and eradication of Borna disease in cattle. ... Borna disease in cattle (consensus report)].}, author={Meinolf ... Borna disease in cattle (consensus report)].. @article{Stber1999BornaDI, title={[ ... prevention and eradication of Borna disease in cattle. ...
more infohttps://www.semanticscholar.org/paper/%5BBorna-disease-in-cattle-%28consensus-report%29%5D.-St%C3%B6ber-Pohlenz/daf38171f4dcf5642d4cdfee1ed678073ee1fe18
  • Borna disease in the horse gives rise to signs like: Unusual posture, gait and ear positions Movement Disturbances (principally ataxia or excess movement) The first antibodies to BoDV-1 in humans were discovered in the mid-1980s. (wikipedia.org)
  • Antibodies against ABV were detected by use of an IIFA on persistently Borna disease virus (BDV)-infected Madin-Darby canine kidney cells. (thefreedictionary.com)
  • The diagnosis of Boma disease is established intra vitam on the basis of the clinical symptoms and the presence of antibodies in serum or cerebrospinal fluid (CSF), as well as by new ELISA methods measuring specific antigen and immune complexes. (scialert.net)
  • Seeger, J. 2000-01-01 00:00:00 Neuron-glia interactions in the Borna disease virus (BDV)-infected rat retina were investigated with emphasis on the ultrastructural characterization of degenerative alterations in the ganglion cell and photoreceptor layer. (deepdyve.com)
  • It is not surprising then that one of the hottest topics in medical research these days is viral involvement in chronic nervous system diseases and mental illness. (masterjules.net)
  • citation needed] The issue is further complicated by the fact that amantadine is also used in the treatment of Parkinson's disease and may have direct effects on the nervous system. (wikipedia.org)
  • Borna disease, is caused by a virus which damages the nervous system. (thepigsite.com)
  • Animals suffering from Borna disease develop motor and behavioural disorders. (laboklin.com)
  • The study of Borna disease virus (BDV) and BD has broad impact on diverse areas of biology and medicine, notably on molecular genetics of RNA virus, neurobiology, biological psychiatry, and public health. (asmscience.org)
  • The most recent experiments demonstrate the utility of the BDV model for studying the pathophysiological mechanisms of the gene-environment interaction that determines differential disease outcomes and variability in responses to treatments. (elsevier.com)
  • In addition to peracute and acute deaths, especially in older birds chronic progressions of the disease can also be observed. (laboklin.com)