A species in the genus Bornavirus, family BORNAVIRIDAE, causing a rare and usually fatal encephalitic disease in horses and other domestic animals and possibly deer. Its name derives from the city in Saxony where the condition was first described in 1894, but the disease occurs in Europe, N. Africa, and the Near East.
An encephalomyelitis of horses, sheep and cattle caused by BORNA DISEASE VIRUS.
Viruses whose taxonomic relationships have not been established.
An order comprising four families of eukaryotic viruses possessing linear, non-segmented, negative-strand RNA genomes. The families are BORNAVIRIDAE; FILOVIRIDAE; PARAMYXOVIRIDAE; and RHABDOVIRIDAE.
Proteins found in any species of virus.
A genus of the family POXVIRIDAE, subfamily CHORDOPOXVIRINAE, which infect ungulates and may infect humans. ORF VIRUS is the type species.
Diseases of domestic and wild horses of the species Equus caballus.
A family in the order MONONEGAVIRALES comprising one genus Bornavirus. This family has a unique form of mRNA processing: replication and transcription takes place in the nucleus.
Ribonucleic acid that makes up the genetic material of viruses.
Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Proteins conjugated with nucleic acids.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
An inflammatory process involving the brain (ENCEPHALITIS) and meninges (MENINGITIS), most often produced by pathogenic organisms which invade the central nervous system, and occasionally by toxins, autoimmune disorders, and other conditions.
Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.
Substances elaborated by viruses that have antigenic activity.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
The type species of PARAPOXVIRUS which causes a skin infection in natural hosts, usually young sheep. Humans may contract local skin lesions by contact. The virus apparently persists in soil.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
Established cell cultures that have the potential to propagate indefinitely.
The systematic study of the complete complement of proteins (PROTEOME) of organisms.
Electrophoresis in which a second perpendicular electrophoretic transport is performed on the separate components resulting from the first electrophoresis. This technique is usually performed on polyacrylamide gels.
The most well known avian paramyxovirus in the genus AVULAVIRUS and the cause of a highly infectious pneumoencephalitis in fowl. It is also reported to cause CONJUNCTIVITIS in humans. Transmission is by droplet inhalation or ingestion of contaminated water or food.
The protein complement of an organism coded for by its genome.
The type species of APHTHOVIRUS, causing FOOT-AND-MOUTH DISEASE in cloven-hoofed animals. Several different serotypes exist.
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
A group of mental disorders associated with organic brain damage and caused by poisoning from alcohol.
Viruses whose genetic material is RNA.
Affection; in psychiatry commonly refers to pleasure, particularly as it applies to gratifying experiences between individuals.
The study of literature written in the Romance languages (French, Spanish, Italian, and others descended from Latin), including grammar, etymology, criticism, literary history, and language and linguistic history.
Substances that are energetically unstable and can produce a sudden expansion of the material, called an explosion, which is accompanied by heat, pressure and noise. Other things which have been described as explosive that are not included here are explosive action of laser heating, human performance, sudden epidemiological outbreaks, or fast cell growth.
The mechanical process of cooling.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).
Pathogenic infections of the brain, spinal cord, and meninges. DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal infections; PROTOZOAN INFECTIONS; HELMINTHIASIS; and PRION DISEASES may involve the central nervous system as a primary or secondary process.
The ability to detect chemicals through gustatory receptors in the mouth, including those on the TONGUE; the PALATE; the PHARYNX; and the EPIGLOTTIS.
An acute febrile, contagious, viral disease of birds caused by an AVULAVIRUS called NEWCASTLE DISEASE VIRUS. It is characterized by respiratory and nervous symptoms in fowl and is transmissible to man causing a severe, but transient conjunctivitis.

A serosurvey of Borna disease virus infection in wild rats by a capture ELISA. (1/148)

For a serological diagnostic test for Borna disease (BD), we developed a capture ELISA with specificity and sensitivity based on detection of antibodies against BD virus (BDV) p40 protein. Using our capture ELISA system, the antibody response of rats inoculated intracerebrally with BDV at 4 weeks after birth showed a sharp increase from 1 to 4 weeks postinoculation (p.i.) and a steady level after 5 weeks p.i. To investigate prevalence of BDV infection among wild rats, we examined sera of Rattus norvegicus in Kami-iso town, Oshima district, Hokkaido, suggesting that rats in this area had not been infected by BDV.  (+info)

T cell ignorance in mice to Borna disease virus can be overcome by peripheral expression of the viral nucleoprotein. (2/148)

Infection of neonates with Borna disease virus (BDV) induces severe meningoencephalitis and neurological disorder in wild-type but not in beta(2)-microglobulin-deficient mice of strain MRL (H-2(k)). Temporary in vivo depletion of CD8(+) T cells delayed BDV-induced disease for several weeks. Depletion of CD4(+) T cells had a similar beneficial effect, indicating that the BDV-induced neurological disorder in mice is a CD4(+) T cell-dependent immunopathological process that is mediated by CD8(+) T cells. Lymphocytes prepared from brains of diseased mice were mainly from the CD8(+) T cell subset. They showed up-regulation of activation markers and exerted strong MHC I-restricted cytotoxic activity against target cells expressing the BDV nucleoprotein p40. Infection of B10.BR (H-2(k)) or congenic C57BL/10 (H-2(b)) mice resulted in symptomless, lifelong persistence of BDV in the brain. Superinfection with a recombinant vaccinia virus expressing BDV p40 but not with other vaccinia viruses induced severe neurological disease and encephalitis in persistently infected B10.BR mice but not in persistently infected C57BL/10 mice, indicating that the disease-inducing T cell response is restricted to the nucleoprotein of BDV in H-2(k) mice. Our results demonstrate that the cellular arm of the immune system may ignore the presence of a replicating virus in the central nervous system until proper antigenic stimulation at a peripheral site triggers the antiviral response.  (+info)

Detection of borna disease virus-reactive antibodies from patients with psychiatric disorders and from horses by electrochemiluminescence immunoassay. (3/148)

The prevalence of Borna disease virus (BDV)-specific antibodies among patients with psychiatric disorders and healthy individuals has varied in several reports using several different serological assay methods. A reliable and specific method for anti-BDV antibodies needs to be developed to clarify the pathological significance of BDV infections in humans. We developed a new electrochemiluminescence immunoassay (ECLIA) for the antibody to BDV that uses two recombinant proteins of BDV, p40 and p24 (full length). Using this ECLIA, we examined 3,476 serum samples from humans with various diseases and 917 sera from blood donors in Japan for the presence of anti-BDV antibodies. By ECLIA, 26 (3.08%) of 845 schizophrenia patients and 9 (3.59%) of 251 patients with mood disorders were seropositive for BDV. Among 323 patients with other psychiatric diseases, 114 with neurological diseases, 75 with chronic fatigue syndrome, 85 human immunodeficiency virus-infected patients, 50 with autoimmune diseases including rheumatoid arthritis and systemic lupus erythematosis and 17 with leprosy, there was no positive case except one case each with alcohol addiction, AIDS, and dementia. Although 19 (1.36%) of 1,393 patients with various ocular diseases, 10 (1.09%) of 917 blood donors, and 3 (4.55%) of 66 multitransfused patients were seropositive for BDV-specific antigen, high levels of seroprevalence in schizophrenia patients and young patients (16 to 59 years old) with mood disorders were statistically significant. The immunoreactivity of seropositive sera could be verified for specificity by blocking with soluble p40 and/or p24 recombinant protein. Anti-p24 antibody was more frequent than p40 antibody in most cases, and in some psychotic patients antibody profiles showed only p40 antibody. Although serum positive for both p40 and p24 antibodies was not found in this study, the p40 ECLIA count in schizophrenia patients was higher than that of blood donors. Furthermore, we examined 90 sera from Japanese feral horses. Antibody profiles of control human samples are similar to that of naturally BDV-infected feral horses. We concluded that BDV infection was associated in some way with psychiatric disorders.  (+info)

Borna disease virus in human brains with a rare form of hippocampal degeneration but not in brains of patients with common neuropsychiatric disorders. (4/148)

To estimate the frequency of persistent Borna disease virus (BDV) infections of the human central nervous system and to determine which neuropsychiatric disorders might be associated with this viral infection, reverse transcription-nested polymerase chain reaction was used to screen a large collection of autopsy brain samples for the presence of BDV-specific nucleic acids. The presence of BDV RNA was found in 3 brains of persons with psychiatric symptoms and prominent hippocampal degeneration previously reported to be positive by others. However, no BDV RNA was detected in 86 randomly collected brains from persons with various psychiatric disorders, including schizophrenia, affective disorders, and Alzheimer's disease, or from suicide victims or in 52 brains from healthy controls. Furthermore, no BDV-RNA was detected in 16 surgical brain samples from persons with epilepsy-associated hippocampal sclerosis. These results indicate that life-long persistent BDV infections are rare in humans and that such infections may be associated with certain forms of hippocampal degeneration.  (+info)

Borna disease virus infection in domestic cats: evaluation by RNA and antibody detection. (5/148)

Borna disease virus (BDV) infection has been suggested to cause spontaneous neurological disease in cats referred to as staggering disease. However the evaluation of BDV infection in neurologically asymptomatic cats remained unclear. In the present study, BDV infected, asymptomatic cats in Tokyo were surveyed both by the presence of plasma antibodies against BDV-p24 and -p40 and by RNA detection in peripheral blood mononuclear cells. Seven of 32 domestic cats (21.9%) were serologically or genetically judged to be BDV-infected. Six cats were positive for anti-BDV antibody and two cats were positive for BDV RNA. Within the 2 RNA-positive cats, only one was positive for anti-BDV antibodies. Furthermore, the findings of anti-BDV-p40 and anti-BDV-p24 antibody-positive cats did not completely overlap. These results suggest that there are neurologically asymptomatic domestic cats infected with BDV present in the Tokyo area.  (+info)

Synaptic pathology in Borna disease virus persistent infection. (6/148)

Borna disease virus (BDV) infection of newborn rats leads to a persistent infection of the brain, which is associated with behavioral and neuroanatonomical abnormalities. These disorders occur in the absence of lymphoid cell infiltrates, and BDV-induced cell damage is restricted to defined brain areas. To investigate if damage to synaptic structures anteceded neuronal loss in BDV neonatally infected rats, we analyzed at different times postinfection the expression levels of growth-associated protein 43 and synaptophysin, two molecules involved in neuroplasticity processes. We found that BDV induced a progressive and marked decrease in the expression of these synaptic markers, which was followed by a significant loss of cortical neurons. Our findings suggest that BDV persistent infection interferes with neuroplasticity processes in specific cell populations. This, in turn, could affect the proper supply of growth factors and other molecules required for survival of selective neuronal populations within the cortex and limbic system structures.  (+info)

Expression and characterization of the Borna disease virus polymerase. (7/148)

Borna disease virus is the prototype of a new family, Bornaviridae, within the order Mononegavirales, that is characterized by nuclear transcription, splicing, low level replication, and neurotropism. The products of five open reading frames predicted from the genomic sequence have been confirmed; however, expression of the sixth, corresponding to the putative viral polymerase (L), has not been demonstrated. Here, we describe expression and characterization of a 190-kDa protein proposed to represent L. Expression of this protein from the third transcription unit of the viral genome is dependent on a splicing event that fuses a small upstream open reading frame in frame with the larger downstream continuous open reading frame. The protein is detected by serum antibodies from infected rats and is present in the nucleus, where it colocalizes with the phosphoprotein. L is also shown to be phosphorylated by cellular kinases and to interact with the viral phosphoprotein in coimmunoprecipitation studies. These findings are consistent with the identity of the 190-kDa protein as the viral polymerase and provide insights and describe reagents that will be useful for Bornavirus molecular biology and pathobiology.  (+info)

Isolation and characterization of a new subtype of Borna disease virus. (8/148)

Borna disease virus (BDV), the causative agent of severe meningoencephalitis in a wide variety of animal species, has been considered to be genetically invariable and to form a single type within the genus Bornavirus of the family Bornaviridae. BDV infections are of particular interest, because for the first time a virus infection appears to be linked to human psychiatric disorders. We now describe a new subtype of BDV isolated from a horse which was euthanatized due to severe, incurable neurological disease. The nucleotide sequence of this new strain, named No/98, differs from the reference strains by more than 15%, and the subtype is difficult to detect by standard reverse transcriptase PCR protocols. The nucleotide exchanges of the novel BDV isolate have surprisingly little effect on the primary structures of most viral proteins, with the notable exception of the X protein (p10), which is only 81% identical to its counterpart in reference strains. Our data indicate that the genome of BDV is far more variable than previously assumed and that naturally occurring subtypes may escape detection by currently used diagnostic assays.  (+info)

TY - JOUR. T1 - Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection. AU - Bautista, Jan R.. AU - Schwartz, Gary J.. AU - De La Torre, Juan Carlos. AU - Moran, Timothy H. AU - Carbone, Kathryn M.. PY - 1994. Y1 - 1994. N2 - Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), with no signs of encephalitis or Borna disease. We measured body weight, body length, taste preferences, and spontaneous locomotor activity over a 4-month period in PTI-NB and control rats. PTI-NB rats had decreased weight and length but not detectable disturbances in growth hormone and insulin-like growth factor-1 biosynthesis as compared to control rats. In single bottle taste acceptance tests, PTI-NB rats did not differ from controls and drank normal amounts of all solutions. When offered a choice of solutions in two-bottle taste preference tests, PTI-NB rats exhibited a normal preference for saccharin and a ...
Characterization of the Borna disease virus phosphoprotein, p23.: Borna disease virus infection is diagnosed by the presence of serum antibodies reactive with t
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): This article cites 58 articles, 23 of which can be accessed free
Borna disease virus (BDV) is a non-segmented, negative-strand RNA virus that replicates and transcribes its genome in the nucleus of infected cells. It uses the cellular splicing machinery to generate a set of alternatively spliced mRNAs from the 2.8 and 7.1 kb primary transcripts, each harbouring two introns. To determine whether splicing of these transcripts is regulated by viral factors, the extent of splicing was studied in infected cells and COS-7 cells transiently transfected with plasmids encoding the 2.8 kb RNA of BDV. Unspliced RNA was found to be the most abundant RNA species in infected cells, whereas viral transcripts lacking both introns were only found in minute amounts. In sharp contrast, plasmid-derived 2.8 kb RNA was predominantly intron 1-spliced and double-spliced. Co-expression of the BDV proteins P, N and X did not influence splicing of plasmid-expressed 2.8 kb RNA. Furthermore, the splicing pattern did not change when the 2.8 kb RNA was expressed in BDV-infected cells. Based on
Borna disease virus, a newly classified nonsegmented negative-strand RNA virus with international distribution, infects a broad range of warm-blooded animals from birds to primates. Infection causes movement and behavioral disturbances reminiscent of some neuropsychiatric syndromes. The virus has not been clearly linked to any human disease; however, an association between infection with the virus and selected neuropsychiatric disorders has been suggested. We reviewed recent advances in Borna disease virus research, focusing on evidence of infection in humans ...
Detection and sequence analysis of borna disease virus p24 RNA from peripheral blood mononuclear cells of patients with mood disorders or schizophrenia and of b
Read Neuron-glia interactions in the rat retina infected by Borna disease virus, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Previous studies have shown that schizophrenics and those with mood disorders have higher levels of Borna Disease Virus (BDV) RNA and anti-BDV antibodies. The researchers in this study aimed to determine the relationship between infection with Borna Disease Virus (BDV) and schizophrenia and other mood disorders, with respect to symptom subtypes and clinical time course. 32 schizophrenics and 33 mood disorder patients were tested against 25 controls. Serum was collected from the patients, and Western Blots were used to detect anti-BDV-p10 (nucleoprotein fusion proteins) antibodies. The study found a statistically significant correlation with the levels of anti-BDV antibodies and the mood disorder patients, but the study found no significant correlations in the case with schizophrenia. A significant relationship was found, however, between BDV antibody levels and the type of schizophrenia (productive or positive, against deficit or negative). The study also found a similar relationship between ...
Summary The effect of interferon (IFN) on infection and maintenance of persistent infection of Borna disease (BD) virus in cell cultures was investigated. Acutely BD virus-infected primary rabbit brain and rat lung cells produced significant levels of interferon detectable 3 days post-infection in the culture supernatants. Rat brain and rat lung cells persistently infected with BD virus produced only moderate levels of IFN over a long period. In contrast, persistently infected Madin-Darby canine kidney (MDCK) cells did not produce detectable amounts of IFN. Exogenous homologous IFN completely inhibited the expression of BD virus antigen in acutely infected rabbit brain cells, when added during the first 24 h after infection. IFN added later (2 to 6 days post-infection) reduced virus titres to different degrees depending on the onset of treatment. However, IFN added to persistently infected rat lung cells did not appear to influence the degree or quality of BD virus antigen expression or the
Numerous species of mammals are susceptible to this virus. It is of clinical relevance particularly in horses, in cats (where the disease is also called staggering disease) and in sheep. The virus has a strong neurotropism and triggers non-purulent meningoencephalitis, associated with anorexia, apathy, somnolence and multiple neuronal dysfunctions. Animals suffering from Borna disease develop motor and behavioural disorders. In horses and sheep, in addition to the symptoms listed above, a lowered head posture, separation from the herd, empty chewing and salivation have been described and, at a later stage, recumbency and flailing movements. Cats frequently suffer from hind-leg ataxia and lumbosacral pain.. There is often little or no immune response, which makes it difficult to diagnose by testing for antibodies. The incubation period is unknown. The progression of a clinically manifested infection is lethal (duration of the disease usually 1 - 3 weeks).. Clinically inapparent infections are ...
Borna disease virus replication in organotypic hippocampal slice cultures from rats results in selective damage of dentate granule cells. J Virol 79: 11716-23. (#: these authors were co-senior authors) H. Brinks, S. Conrad, J. Vogt, J. Oldekamp, A. Sierra, L. Deitinghoff, I. Bechmann, G. Alvarez-Bolado, B. Heimrich#, P.P. Monnier#, B.K. Müller#, and T. Skutella# (2004 ...
Borna disease virus replication in organotypic hippocampal slice cultures from rats results in selective damage of dentate granule cells. J Virol 79: 11716-23. (#: these authors were co-senior authors) J. Schwenk, N. Harmel, G. Zolles, W. Bildl, A. Kulik, B. Heimrich, O. Chisaka, P. Jonas, U. Schulte, B. Fakler, N. Klöcker (2009 ...
The disease in horses is endemic in some regions of Germany and Switzerland. In recent years infections have been reported in cattle, sheep, goats, monkeys, ostriches, cats and humans. Serological evidence from humans indicate that the virus is probably widespread in Europe and North America.. Humans are infected by Borna disease virus and show an antibody response but not clinical disease. Whether or not these infections can be responsible for some psychiatric disorders is currently under investigation. Some serological evidence suggests they may be.. Questions that need to be answered are: What is the prevalence rate in humans? What is the source or sources of human infections? Is there a natural reservoir? Can humans transmit the disease in the way horses do? ...
of all the other SEMINARS, trainings you have? Fat archives with whole seminars in them? I hear there s the HOW TO MARRY WELL seminar, also called the LUCK IN LOVE WEBSITE, 150 articles on the RUTHLESS RULES OF ROMANCE. You send all 150 articles, hear? Im single and I want to see that one. I hear you also have a dynamite HOLISTIC HEALING SECRETS FOR HUMANS course, fifty files long? Heal any disease, prevent any genetic malady pre-existing in my family tree. Could you email me that? And the entire EASY PATH TO BE A MILLIONAIRE SEMINAR (How to avoid taxes, how to run a lucrative Cottage Industry, Frugal living. Frugal Gardening, Building a Farm Home, RECESSION TECH SECRETS, Urban Survival, List of all Future THINGS TO COME.and Jerrys Refrigerator the Conspiracy Theory Archive with the Tin Foil Hat collection of Conspiracy theories, want that one.) Heres TWO BUCKS via PAYPAL! Send the entire SEMINAR to me by EMAIL as soon as you get my payment. I will send you my e-mail address ---oh, actually ...
Borna disease virus (BDV) The only species in the genus Bornavirus. Named after a town in Saxony where the first major outbreak in horses occurred. Negative-strand RNA virus which produces persistent infection in a variety of experimental …. The London encyclopaedia, or, Universal dictionary of science, art, literature, and practical mechanics, by the orig. ed. of the Encyclopaedia metropolitana [T. Curtis]. (1839). by Thomas Curtis (of Grove house sch, Islington ...
Perez, M., Clemente, R., Robison, C. S., Jeetendra, E., Jayakar, H. R., Whitt, M. A., de la Torre, J. C. Generation and characterization of a recombinant vesicular stomatitis virus expressing the glycoprotein of Borna disease virus Journal of Virology 2007 81:5527-5536 DOI:10.1128/jvi.02586-06 PMID:17376911 ...
Borna disease virus 1 (BoDV-1) has been associated with human disease in four cases in Germany resulting in the death of three people. As three of the cases belong to a cluster of solid organ recipients from a single donor, donor-derived BoDV-1 transmission is possible. There is no evidence that the donor had any clinical manifestation of the disease. ...
Serological incidence of Gumboro disease virus infection in chicken flocks in Cairo district. , Amer, M. M.,.Bastami M. A., D.G.khilfa, and Hamouda A. S. , Assut. Vet. Med. J., , Volume 17, Issue 33, p. 211-216., (1986 ...
This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 25-31 March 2018 and includes updates on dengue, chikungunya, measles, listeria, Borna diseases and gonorrhoeae. ...
Borna disease virus-1 (BoDV-1) was recently discovered as cause of severe and often fatal encephalitis in humans. BoDV-1 is known to cause neurological disease in horses and sheep mainly in South and Central Germany. The virus is maintained in bicolored white-toothed shrews (Crocidura leucodon). The incidence of infection and risk factors in humans are completely unresolved. Veterinarians may be disproportionally BoDV-1-exposed through contact to animals not recognized to be BoDV-1 infected. We conducted three serosurveys predominantly in endemic areas of South Germany for the presence of BoDV-1-reactive antibodies. Anonymized residual samples from two serosurveys of veterinarians (n = 736) with interview data on exposures and one serosurvey among blood donors (n = 373) were screened with an indirect immunofluorescence antibody test, followed by a newly developed immunoblot as confirmatory assay. One serum from a 55-59-year-old veterinarian who worked in an animal practice and as a meat ...
The bicoloured shrew (Crocidura leucodon) lives exclusively in Central Europe, the region where the Borna disease occurs. This area is mostly within Germany, but also includes the eastern part of Switzerland and Vorarlberg in western Austria. Virologist Nowotny explains: The distribution of bicoloured shrews remains fairly constant because the animals stay within their habitats. They do not like to move around. In fact, the number of incidents of Borna disease has actually declined in the last few years. There are currently about 100 cases per year.. Genetics reveals transmission mechanism. A genetic analysis of viruses taken from bicoloured shrews and horses provides further proof that the bicoloured shrew acts as a pathogen reservoir. The viral strains found in the shrews correspond exactly with the strains from sick horses in the same region. This supports the assumption that the virus sub-types develop in a particular region over the course of centuries in bicoloured shrews and do not ...
Borna disease virus (BDV) The only species in the genus Bornavirus. Named after a town in Saxony where the first major outbreak in horses occurred. Negative-strand RNA virus which produces persistent infection in a variety of experimental …. The London encyclopaedia, or, Universal dictionary of science, art, literature, and practical mechanics, by the orig. ed. of the Encyclopaedia metropolitana [T. Curtis]. (1839). by Thomas Curtis (of Grove house sch, Islington ...
Yamaguchi, Kazunari et al Detection of Borna Disease Virus-Reactive Antibodies from Patients with Psychiatric Disorders and from Horses by Electrochemiluminescence Immunoassay. Clinical and Diagnostic Laboratory Immunology 6.5 (1999): 696-700. Web. 15 Aug. 2020. ...
Although interferon-gamma (IFN-) has a critical function in the noncytolytic elimination of several neurotropic viral infections, the signaling response to the cytokine is not characterized in primary... Read More ...
Summary The production, purification and properties of the A antigen induced by Marek's disease virus in tissue culture were investigated. It was found that although virus multiplied on passage in chick kidney, chick embryo and duck embryo cells the antigen was produced only in chick kidney and duck embryo cultures. The results suggested that the A antigen produced by duck embryo cells was a glycoprotein having a mol. wt. in the range 70 000 to 90 000 and was heterogeneous in charge (pI 4.5 to 5.5). A 20-fold purification was achieved by electrophoresis in 5% acrylamide gel with a recovery of 45%. An equally good purification was also possible by chromatography on DEAE-Sephadex A50 and Sephadex G200, although the recovery was only 20% in this case.
Mareks disease (MD), a herpesvirus-induced lymphomatous disease in chickens, has attracted the interest of immunologists since MD virus (MDV) was isolated in 1968 and vaccines became available shortl
Bornaviridae is a family of viruses in the order Mononegavirales. Horses, sheep, cattle, rodents, birds, reptiles, and humans serve as natural hosts. Currently, 16 viruses are assigned to eight species included in one genus in this family. Diseases associated with bornaviruses include Borna disease, a fatal neurologic disease of mammals restricted to central Europe; and proventricular dilatation disease in birds. Borna disease was first identified in 1926 and its genome was isolated in 1990. The viral family is named after the city of Borna in Saxony, Germany, which is where a large number of animals were lost to the sporadic encephalopathy caused by the viral disease. Table legend: * denotes type species. Bornavirions are enveloped, with spherical geometries. The diameter is around 70 to 130 nm. Genomes are linear, around 8.9kb in length. The genome codes for 9 proteins. Below are a few of the essential proteins of Bornaviridae that have been characterized. Viral replication is nuclear. Entry ...
The hematological lesions consequent upon velogenic Newcastle disease virus (NDV) infection were investigated in 6-week-old ducks and chickens. Following intramuscular inoculation, the results indicated significantly lower (p
Bai, Y, Yuan, P, Zhang, H, Ramachandran, R, Yang, N & Song, J 2020, Adiponectin and its receptor genes expression in response to Mareks disease virus infection of White Leghorns, Poultry science, vol. 99, no. 9, pp. 4249-4258. https://doi.org/10.1016/j.psj.2020.06.004 ...
Foot-and-mouth disease virus (FMDV) is a single stranded RNA virus in the picornavirus family. It is the causative agent of foot-and-mouth disease, globally the most important a�iction of cloven hoofed animals. The FMDV genome has several features that are not found amongst other viruses within the Picornaviridae. These include a large 50 untranslated region (UTR), almost twice the length of that found in enteroviruses, containing highly structured RNA elements unique to FMDV, such as the S-fragment and several tandemly repeated pseudoknots. Unique aspects are also found within the coding region, where FMDV is the only picornavirus reported to contain multiple copies of the 3B gene. The reasons behind possession of these unusual deviations from the dogma of the picornaviral genome is so far unknown and therefore poses an attractive target for further research. The S-fragment is a predicted 360 nucleotide stem-loop at the 50 end of the FMDV genome. The better studied poliovirus (PV) has a well ...
Mononegavirales adalah ordo virus RNA yang berada dalam filum Negarnaviricota dan kelas Monjiviricetes.[1] Nama Mononegavirales berasa dari bahasa Yunani μóνος [monos] yang merujuk pada genom untai tunggal pada sebagian besar ordo ini, bahasa Latin negare yang merujuk pada sifat sense-negatif genom virus, serta akhiran -virales yang menunjukkan ordo virus.[2] Anggota ordo ini yang dikenal di antaranya virus rabies dan virus Ebola yang dapat menyebabkan penyakit, baik pada manusia maupun hewan. ...
Jembrana disease virus (JDV) is an acute lentiviral infection of Bali cattle in Indonesia. Data generated during a series of cattle infection experiments was examined and significant differences were identified in the mean plasma viral load on the first and second days of the febrile response in cattle infected with JDVTAB/87 compared to those infected with JDVPUL/01. The peak and total viral loads ,= 106 genome copies/ml during the acute stage of the disease were significantly higher in JDVTAB/87 infected cattle. JDVPUL/01 infected cattle developed peak rectal temperatures earlier than the JDVTAB/87 cattle but there were no differences in the duration of the febrile responses observed for the 2 groups of animals. The plasma viremia was above 106 genome copies/ml for almost 3 days longer in JDVTAB/87 compared to JDVPUL/01 infected cattle. Atypical responses to infection occurred in approximately 15% of experimentally infected animals, characterized by reduced viral loads, lower or absent febrile ...
While the disease has been studied for over two decades, it has only been since 2008 that avian bornavirus infection has been linked to PDD. With the recent discovery of the avian bornavirus relationship to PDD, we have learned a lot (and created more questions).. Bornavirus is a RNA type virus and has previously been reported to cause, or is associated with, disease in rats, horses, primates, chickens, pigs, humans and now parrots and finches. Avian bornavirus, as opposed to borna disease virus recognized in other animals, is now confirmed as at least one cause of PDD in parrots. It is speculated, but not proven, that avian bornavirus triggers an autoimmune reaction whereby the birds immune system attacks its own nervous tissue.. At this time, there appear to be seven avian bornavirus genotypes that affect parrots species differently. While most infections are of one genotype, recent research supports multiple genotype infection is possible. To make things more confusing, there is also a ...
Jembrana disease was reported initially in Bali cattle (Bos javanicus) on Bali island in 1964 and the causative agent was subsequently identified as a bovine lentivirus and designated Jembrana disease virus (JDV). This atypical lentivirus causes an acutely pathogenic disease that is associated with clinical signs and pathological lesions attributable to a disease primarily affecting the lymphoid system. Based on the intense proliferation of cells in the parafollicular (T-cell) areas of lymphoid tissue it has been assumed that the cellular tropism of the virus was for T-cells.. An initial investigation of the pathological changes following JDV infection provided morphological evidence that JDV infection occurred not in T-cells but probably in centroblast-like cells containing IgG and presumably of B-cell lineage. The identity of the infected cells was confirmed by double immunofluorescence labelling techniques as being IgG-containing CD79α+ cells, indicating that the virus replicated in mature ...
Foot-and-mouth disease virus (FMDV) can cause transplacental infection and death in fetal lambs. This study investigates the pathogenesis of FMDV infection in ovine fetuses using in-situ hybridization (ISH) to detect viral transcripts in tissue and real-time reverse transcriptase polymerase chain reaction (RT-PCR) assays to quantify the fetal cytokine response to infection. FMDV ribonucleic acid (RNA) was localized mainly to the heart and skeletal muscles of fetuses and was only occasionally expressed in the lingual epithelium, demonstrating that FMDV has a different tissue tropism in the fetus compared with that in adult sheep. There was early expression of genes encoding anti-viral cytokines (IFN-alpha and IFN-beta) in fetuses at 2 and 4 days post-infection (dpi), followed by a marked rise in the transcription of pro-inflammatory cytokine genes (IFN-gamma, TNF-alpha and IL-1 alpha) from 7 to 18 dpi, particularly in the heart. The degree of cytokine mRNA expression correlated with fetal ...
Conventional and nude mice inoculated with syngeneic or allogenic tumor cells developed a rapid rise in serum interferon (IF) levels, peaking within 24 h. Within the same period, natural killer (NK) activity was readily boosted in the spleen. Both activities usually declined at 3 d. Cells that lacked the ability to augment NK activity also failed to induce detectable levels of IF. The boosting of IF and NK functions did not appear to be a result of contamination of the tumor lines by viruses because inoculation of several type C viruses into normal mice had no effect, and other viruses, like lymphocytic choriomeningitis virus and influenza, elevated IF and NK levels with a significantly later kinetics, peaking 3-4 d. The IF induced by tumor cells was heat and acid labile, species specific, and appeared to be in the type II class, although it was susceptible to antisera against Newcastle disease virus-induced IF. These data suggest that an early, nonthymus-dependent consequence of tumor-cell ...
Assessing the potential spread and maintenance of foot-and-mouth disease virus infection in wild ungulates: general principles and application to a specific scenario in Thrace. / Dhollander, S.; Belsham, Graham; Lange, M.; Willgert, K.; Alexandrov, T.; Chondrokouki, E.; Depner, K.; Khomenko, S.; Özyörük, F.; Salman, M.; Thulke, H.-H.; Bøtner, Anette.. In: Transboundary and Emerging Diseases, Vol. 63, No. 2, 2016, p. 165-174.. Publication: Research - peer-review › Journal article - Annual report year: 2014 ...
Citation: Zhang, H., Xie, Q., Chang, S., Ernst, C.W., Song, J. 2014. Preliminary Analysis of MicroRNA Transcriptome Altered by Vaccine and Mareks Disease Virus in Chickens. Plant and Animal Genome Conference. Paper No. 9952. Available: https://pag.confex.com/pag/xxii/webprogram/Paper9952.html. Interpretive Summary: Technical Abstract: MicroRNAs are a class of small, non-coding RNAs that regulate gene expression at the post-transcriptional level and play important roles in many biological processes such as development, cell signaling and immune response. Mature miRNAs are about 22 nucleotides in length. Reportedly, the growth of various tumors, including cancers, is mediated by dysfunctional regulation by miRNAs, and differential expression of miRNA is associated with virus infection and tumorigenesis. This study was aimed to explore the microRNA transcriptome and to profile microRNA expression in response to vaccination or Mareks disease virus infection in two highly inbred lines of chickens ...
Diseases associated with bornaviruses include Borna disease, a fatal neurologic disease of mammals restricted to central Europe ... and proventricular dilatation disease in birds. Borna disease was first identified in 1926 and its genome was isolated in 1990 ... "Borna". Veterinary Microbiology and microbial disease, 2nd edition, P J Quinn et al. Wiley-Blackwell Hoffmann, Bernd; Tappe, ... The viral family is named after the city of Borna in Saxony, Germany, which is where a large number of animals were lost to the ...
Lipkin, W. I; Hornig, M; Briese, T (2001). "Borna disease virus and neuropsychiatric disease--a reappraisal". Trends in ... "Does Borna Disease Virus Cause Mental Health? Stephanie Berger. Columbia University Mailman School of Public Health. January 31 ... Lipkin, W. I; Travis, G. H; Carbone, K. M; Wilson, M. C (1990). "Isolation and characterization of Borna disease agent cDNA ... Bode, L; Ludwig, H (2003). "Borna Disease Virus Infection, a Human Mental-Health Risk". Clinical Microbiology Reviews. 16 (3): ...
... white-toothed shrew is a natural reservoir species for the Borna disease virus which is the causative agent of Borna disease, a ... "Shrews as Reservoir Hosts of Borna Disease Virus". Emerging Infectious Diseases. 12 (4): 675-677. doi:10.3201/eid1204.051418. ... Kamhieh S, Flower RL (June 2006). "Borna disease virus (BDV) infection in cats. A concise review based on current knowledge". ... Rott, R.; Herzog, S.; Bechter, K.; Frese, K. (1991). "Borna disease, a possible hazard for man?". Archives of Virology. 118 (3- ...
A study investigating the effects of the Borna disease virus on treeshrews has given new insight into neurological disease. ... Sprankel, H., Richarz, K., Ludwig, H. and Rott, R. (1978). Behavior Alterations in Tree Shrews Induced by Borna Disease Virus. ... Recent studies have used treeshrews to study infectious, metabolic, neurological, and psychiatric diseases, as well as cancers ... emerging model of human diseases. Dongwuxue Yanjiu 34(2): 59-69. (in Chinese) Yang, Z. F., Zhao, J., Zhu, Y. T., Wang, Y. T., ...
"Novel Borna Virus in Psittacine Birds with Proventricular Dilatation Disease". Emerging Infectious Diseases. 14 (12): 1883-1886 ... In general these viruses show only about 65% sequence identity with mammalian Borna disease virus 1 (BoDV-1). The overall ... Avian bornaviruses have been reported, yet not proven, as the cause of proventricular dilatation disease (PDD), a disease of ... "Use of Avian Bornavirus Isolates to Induce Proventricular Dilatation Disease in Conures". Emerging Infectious Diseases. 16 (3 ...
"Modulation of miR-122 on persistently Borna disease virus infected human oligodendroglial cells". Antiviral Res. 87 (2): 249- ... Biomarkers in Liver Disease. V. B. Patel and V. R. Preedy. Dordrecht, Springer Netherlands: ISBN 978-94-007-7675-3, page 193- ... This change is noted before increased amino-transferase activity, making it an early indicator of liver disease and ... and Chemical-Related Hepatic Diseases". Clin Chem. 56 (12): 1830-1838. doi:10.1373/clinchem.2010.147850. PMID 20930130. Xu H, ...
Pletnikov, M. V.; Moran, T. H.; Carbone, K. M. (2002). "Borna disease virus infection of the neonatal rat: Developmental brain ... Much research has been done into the use of a rat model to show how Borna virus infection, exposure to valproic acid in utero, ... Centers for Disease Control (2008-02-08). "Mercury and vaccines (thimerosal)". Retrieved 2011-08-01. Crawley, J. N. (2012). " ... Klauck, S. M.; Poustka, A. (2006). "Animal models of autism". Drug Discovery Today: Disease Models. 3 (4): 313-318. doi:10.1016 ...
Borna Disease Virus, das Virus der Bornaschen Krankheit, mit Species Mammalian 1 orthobornavirus (Typus) u. a. ... D. Qian et al.: Extra small virus-like particles (XSV) and nodavirus associated with whitish muscle disease in the giant ...
Nöske K, Bilzer T, Planz O, Stitz L (1998). "Virus-Specific CD4+ T Cells Eliminate Borna Disease Virus from the Brain via ...
... where she studied the virus associated with Borna disease. She joined the faculty of Colorado State University in 1990 and ... Susan (Sue) VandeWoude is a veterinarian and researcher in the United States, specializing in viral diseases of cats. She is ...
Thogoto and Borna disease viruses". Virus Research. 95 (1-2): 3-12. doi:10.1016/S0168-1702(03)00159-X. PMID 12921991.. ... Archives of Disease in Childhood. 85 (5): 351-53. doi:10.1136/adc.85.5.351. PMC 1718987. PMID 11668090. Archived (PDF) from the ... because the symptoms can be similar to those of other respiratory diseases.[189][190] The disease may have spread from Europe ... a b Time Lines of Infection and Disease in Human Influenza: A Review of Volunteer Challenge Studies Archived 13 June 2012 at ...
Thogoto and Borna disease viruses". Virus Res. 95 (1-2): 3-12. doi:10.1016/S0168-1702(03)00159-X. PMID 12921991.. ... 2007). Epidemiology and Prevention of Vaccine-Preventable Diseases (10th ed.). Washington DC: Centers for Disease Control and ... "Avian Influenza (Bird Flu): Implications for Human Disease". Center for Infectious Disease Research & Policy, University of ... "CIDRAP - Center for Infectious Disease Research and Policy. University of Minnesota.. *^ "Flu viruses 'can live for decades' on ...
Polio, measles, varicella-zoster, rubella, herpes simplex virus type 2, maternal genital infections, Borna disease virus, and ... It is a pathogenic theory of disease in which it is thought that a proximal cause of certain cases of schizophrenia is the ... An updated meta-analysis on CNVs for schizophrenia published in 2015 expanded the number of CNVs indicated in the disease, ... 2010-10-26). "Disease-relevant autoantibodies in first episode schizophrenia". Journal of Neurology. 258 (4): 686-688. doi: ...
She directs the clinical core of an international investigation of the role of Borna disease virus in human mental illness and ... based on neonatal rat infection with Borna disease virus. In 2004, Hornig published a controversial paper concluding that, in a ... In the 1990s, Hornig investigated the potential link between the Borna virus and depression in humans. Hornig has been ... in the early stages of the disease had higher levels of cytokines than people without CFS. In the 1990s, Hornig helped to ...
Laboratory rats infected with Borna disease virus show some symptoms similar to those of autism but blood studies of autistic ... or whether they are secondary to the disease processes.[71] As autoantibodies are found in diseases other than ASD, and are not ... Clinical Infectious Diseases. 2009;48(4):456-461. doi:10.1086/596476. PMID 19128068. Lay summary: IDSA, 2009-01-30.. ... a b Centers for Disease Control and Prevention. Measles, mumps, and rubella (MMR) vaccine; 2008-12-23 [Retrieved 2009-02-14]. ...
Bode, L; Ludwig, H (2003). "Borna disease virus infection, a human mental-health risk". Clinical Microbiology Reviews. 16 (3): ... A more up-to-date version of this article which lists more diseases can be found here: List of Chronic Human Diseases Linked to ... Diseases may also be multifactorial, requiring multiple factors to induce disease. For example: in a murine model, Crohn's ... The history of infection and disease were observed in the 1800s and related to the one of the tick-borne diseases, Rocky ...
... borna disease virus MeSH B04.820.455.300 - filoviridae MeSH B04.820.455.300.200 - ebola-like viruses MeSH B04.820.455.300.650 ... borna disease virus MeSH B04.909.777.455.300 - filoviridae MeSH B04.909.777.455.300.200 - ebola-like viruses MeSH B04.909. ... lumpy skin disease virus MeSH B04.280.650.160.500 - leporipoxvirus MeSH B04.280.650.160.500.250 - fibroma virus, rabbit MeSH ... border disease virus MeSH B04.820.250.700.150 - diarrhea viruses, bovine viral MeSH B04.820.250.700.150.100 - diarrhea virus 1 ...
Borna disease virus Family Filoviridae - includes Ebola virus, Marburg virus Family Mymonaviridae Family Nyamiviridae Family ... Notable human retroviruses include HIV-1 and HIV-2, the cause of the disease AIDS. All RNA viruses encoding an RNA-directed RNA ... This nucleic acid is usually single-stranded RNA (ssRNA) but may be double-stranded RNA (dsRNA). Notable human diseases caused ... Ebola virus disease, rabies, polio, mumps, and measles. The International Committee on Taxonomy of Viruses (ICTV) classifies ...
... borna disease MeSH C02.782.580.250 - filoviridae infections MeSH C02.782.580.250.400 - hemorrhagic fever, ebola MeSH C02.782. ... kyasanur forest disease MeSH C02.782.417.505 - lassa fever MeSH C02.782.417.560 - marburg virus disease MeSH C02.782.417.762 - ... swine vesicular disease MeSH C02.782.687.484 - foot-and-mouth disease MeSH C02.782.791.142 - african horse sickness MeSH ... kyasanur forest disease MeSH C02.081.885.550 - nairobi sheep disease MeSH C02.182.500.300 - encephalitis, viral MeSH C02.182. ...
... disease, an infectious neurological syndrome *Bornaviridae, a family of viruses associated with Borna disease ... Borna, a subdivision of Bahretal municipality, Saxony, German. *Borna Dam, an earthfill dam on Borna river near Ambejogai, Beed ... Borna language (Ethiopia), a North Omotic language spoken in western Ethiopia. *Borna snakehead, Channa amphibeus, an extremely ... This disambiguation page lists articles associated with the title Borna.. If an internal link led you here, you may wish to ...
Novel borna virus in psittacine birds with proventricular dilatation disease. Emerging infectious diseases 14(12), 1883-6.e ... Proventricular dilatation disease (PDD) is an incurable probably viral disease of psittacine birds. It was first recognized and ... The disease does not follow a clear path of development or transmission. "All Creatures Health Care". Harrison, and Lightfoot. ... The clinical presentation of this disease varies with the individual as well as in severity of those symptoms. Often the ...
Although Borna disease viruses 1 and 2 are mainly seen as the causative agent of Borna disease in horses and other animals, ... Borna disease, also known as sad horse disease, is an infectious neurological syndrome of warm-blooded animals, caused by Borna ... Borna diseases viruses 1 and 2 appear to have wide host ranges, having been detected in horses, cattle, sheep, dogs and foxes. ... Borna disease in the horse gives rise to signs like: Unusual posture, gait and ear positions Movement Disturbances (principally ...
Borna disease was first described in 1885 as "heated head disease" of cavalry horses in 1885 in the town of Borna, Germany. ... The Borna disease viruses 1 and 2 (BoDV-1 and BoDV-2) are members of the species Mammalian 1 orthobornavirus and cause Borna ... Perez M, Watanabe M, Whitt MA, de la Torre JC (August 2001). "N-terminal domain of Borna disease virus G (p56) protein is ... Wolff T, Pfleger R, Wehner T, Reinhardt J, Richt JA (April 2000). "A short leucine-rich sequence in the Borna disease virus p10 ...
Talk:Borna disease. *Talk:Braak staging. *Talk:Brachial plexus injury. *Talk:Brachioradialis reflex ...
Borna disease virus. *BpuJI. *Bradykinin. *Bradykinin receptor. *Brain-specific angiogenesis inhibitor. *Branched chain amino ...
By extension, the increasing rates of non-communicable diseases in the community is related to the diet and physical activity ... Borna Nyaoke is a Kenyan physician and clinical researcher, who works as a Manager of Clinical Trials at Drugs for Neglected ... Borna Nyaoke was born in Kenya. She attended Kenyan schools for her elementary and secondary education. She was admitted to the ... Following the completion of her first degree, Borna Nyaoke interned at Kenyatta National Hospital, then went on to work as a ...
Cros, J (2003). "Trafficking of viral genomic RNA into and out of the nucleus: influenza, Thogoto and Borna disease viruses". ... Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. 29 (2): 453-4. doi: ... "Centers for Disease Control and Prevention.. *^ Mitamura K, Sugaya N (2006). "[Diagnosis and Treatment of influenza-clinical ... Interim Guidance for the Use of Masks to Control Influenza Transmission Coordinating Center for Infectious Diseases (CCID) 8 ...
Larry Siegel, 93, American humorist, (Mad Magazine, The Carol Burnett Show), Parkinson's disease.[28] ... Monsieur Alain Borner RIP (in French) *^ Former Ryder Cup player Brand Jr. dies at age 60 ... Sunset Strip Legend Lizzie Grey Dies From Lewy Body Disease Complications *^ Hong Kong Bids Farewell To Legendary Actresses ... Martin Mayer, 91, American economist and writer (The Bankers), complications from Parkinson's disease.[333] ...
Systems Biology of Membrane Trafficking (Georg Borner / Proteomic Microscope, Membrane Trafficking, AP-4 Mediated Protein ... Translational Medicine (Inaam Nakchbandi / Fibronectin, Integrin, Bone, Disease). *Mechanisms of Protein Biogenesis (Danny ...
... disease) in cattle, and chronic wasting disease in deer; in humans, prionic diseases include Kuru, Creutzfeldt-Jakob disease, ... Chen C, Chiu Y, Wei F, Koong F, Liu H, Shaw C, Hwu H, Hsiao K. High seroprevalence of Borna virus infection in schizophrenic ... Diseases such as foot-and-mouth disease and bluetongue are caused by viruses.[209] Companion animals such as cats, dogs, and ... Many serious diseases such as Ebola virus disease, AIDS, avian influenza, and SARS are caused by viruses. The relative ability ...
In 2009 only 13 Croatians had been infected with HIV/AIDS and six had died from the disease.[103] In 2008 it was estimated by ... ruled by Ljudevit and Borna, as attested by chronicles of Einhard starting in 818. The record represents the first document of ... The principal cause of death in 2008 was cardiovascular disease at 43.5% for men and 57.2% for women, followed by tumours, at ...
N, 580-629(英語:List of ICD-9 codes 580-629: diseases of the genitourinary system)). *Urologic disease(英語:Urologic disease) *腎病變 ... 玻那病毒Borna virusinfection. *馬爾堡病毒. *裂谷熱Rift Valley fever ... G, 320-359(英語:List of ICD-9 codes 320-359: diseases of the nervous system)). *神經系統疾病(英語:Nervous system disease) *CNS(英語:Central ... J, 460-519(英語:List of ICD-9 codes 460-519: diseases of the respiratory system)). *呼
His recent knee injury, caused by Osgood-Schlatter disease, resulted in his withdrawal from both the Rome Masters and the ... Borna Ćorić, Alexander Zverev and Philipp Kohlschreiber en route before losing to Martin Kližan in three sets. In March, ...
Weakened by celiac disease, she says she evokes the subject in order to "show to those who suffer from it that, if it sometimes ... Bornais, Marie-France (17 January 2011). "Western au coeur du Montana" [Western in the heart of Montana]. Le Journal de Québec ...
A British subject I was born-a British subject I will die. With my utmost effort, with my latest breath, will I oppose the ' ... Canadians have been criticized about such things as the ban on beef since a case of Mad Cow disease was discovered in 2003 in ...
Michael Hanlon, "Out of the darkness The Evening Star is born --- A group of jilted printers had enough and created 'a paper ... His reforms saw the death rate from communicable disease drop from 114 per 100,000 to 27 per 100,000. Hocken also supported the ...
"Young Disease Outburst Boy Anime Unveils Main Cast, More Staff, Manga, October Debut". Anime News Network. Retrieved July 22, ... Borner The Rolling Girls, Hitoshi Triage X, Arashi Mikami (young) Uta no Prince-sama Maji Love Revolutions, Shion Amakusa ... Kisaragi Young Disease Outburst Boy, Yamato Noda No Guns Life, Tetsurō Arahabaki My Hero Academia Season 4, Izuku Midoriya ...
"The country's first special pharmaceutical economic zone was registered in Alborz". Borna News. Retrieved 3 September 2018. " ... research on the medicine of the disease, launching the 4030 phone line with the help of 2,200 doctors and paramedics for ...
... using in the treatment of high-dose diseases such as Multiple sclerosis, blood diseases and cancer, "Research and development ... CS1 maint: discouraged parameter (link) "The First Special Economic Zone of the Country Recorded in Alborz". Borna News. 3 ... Also, "cell therapy" by producing five products for the treatment of skin and heart disease and knee arthritis, production of " ... which are used to treat various cardiovascular, skin and skeletal diseases. In order to provide anticancer drugs in the country ...
La Puissance eclesiastique bornée à l'Ecriture et par Elle..., Amsterdam, 1668. Manuel de Pieté, Middelbourg 1668. Declaration ... The Labadists were unable to cope with jungle diseases, and supplies from the Netherlands were often intercepted by pirates. ...
"Borna Gojo". Wake Forest University. Retrieved April 7, 2017. "Noah Rubin". atptour.com. ATP Tour. Retrieved March 22, 2020. " ... infectious disease Robert Lanza, regenerative medicine Diane Mathis (B.S.), immunohaematology Thomas T. Mackie, preventive ... Bea Bielik, former professional tennis player Romain Bogaerts (Belgian) tennis player Borna Gojo (Croatian) tennis player Jeff ... medicine and infectious disease Willis Maddrey, internal medicine and hepatology Thomas Marshburn, astronaut Jerry Punch, ESPN ...
... and illustrated by Borna Nikola Žeželj. The picture book depicts thumbnails from the lives of two children girl Ana, who has ... "people whose sexual behavior puts them at a high risk of getting blood-borne infectious diseases", and in turn the institute's ... "behaviors or activities that expose them to risk of contracting blood-borne infectious diseases". LGBT persons are not banned ...
Both of these diseases are soil borne. Stem rust diseases: Caused by basidiomycete fungi e.g. Ug99 Viral diseases: Wheat ... Pronin, Darina; Borner, Andreas; Weber, Hans; Scherf, Ann (10 July 2020). "Wheat (Triticum aestivum L.) Breeding from 1891 to ... While coeliac disease is caused by a reaction to wheat proteins, it is not the same as a wheat allergy. Other diseases ... The main wheat-disease categories are: Seed-borne diseases: these include seed-borne scab, seed-borne Stagonospora (previously ...
Borna moved with Ljudevit's father-in-law Dragomuž and their forces from the south-west. At the heat of the Battle of Kupa, his ... The Franks eventually retreated from his lands, with their ranks thinned by disease which the northern forces caught in the ... Borna was too weak, so the Dalmatians defended themselves through sneaky tactics and used attrition as their best ally to ... Borna escaped from the battlefield with the help of his bodyguards. Ljudevit seized the opportunity and breached into and ...
"All That Fire" (featuring Zach Bruce) Lyrics Born - As U Were 02. "I Wanna B W/U" (produced with Lyrics Born) 06. "I've Lost ... "The C.D.C. (Cypher for Disease Control)" (featuring Skoob, Supastition, Torae, Prince Po, Baron and Ruste Juxx) Freeway - Fear ...
Although Borna disease viruses 1 and 2 are mainly seen as the causative agent of Borna disease in horses and other animals, ... Borna disease, also known as sad horse disease, is an infectious neurological syndrome of warm-blooded animals, caused by Borna ... Borna diseases viruses 1 and 2 appear to have wide host ranges, having been detected in horses, cattle, sheep, dogs and foxes. ... Borna disease in the horse gives rise to signs like: Unusual posture, gait and ear positions Movement Disturbances (principally ...
borna disease synonyms, borna disease pronunciation, borna disease translation, English dictionary definition of borna disease ... n vet science a viral disease of mammals, esp horses, caused by a member of the Flaviviridae and characterized by the ... borna disease. Also found in: Medical, Wikipedia. borna disease. (ˈbɔːnə) n. (Veterinary Science) vet science a viral disease ... Borna disease - definition of borna disease by The Free Dictionary https://www.thefreedictionary.com/borna+disease ...
Borna disease was first described in 1885 as "heated head disease" of cavalry horses in 1885 in the town of Borna, Germany. ... The Borna disease viruses 1 and 2 (BoDV-1 and BoDV-2) are members of the species Mammalian 1 orthobornavirus and cause Borna ... Perez M, Watanabe M, Whitt MA, de la Torre JC (August 2001). "N-terminal domain of Borna disease virus G (p56) protein is ... Wolff T, Pfleger R, Wehner T, Reinhardt J, Richt JA (April 2000). "A short leucine-rich sequence in the Borna disease virus p10 ...
Borna disease, is caused by a virus which damages the nervous system. It has been known in horses in Germany and surrounding ...
Proteomic Analysis Reveals Selective Impediment of Neuronal Remodeling upon Borna Disease Virus Infection � † (2008) Cached. * ... title = {Proteomic Analysis Reveals Selective Impediment of Neuronal Remodeling upon Borna Disease Virus Infection � †},. year ...
Borna disease virus infection in Italian children. A potential risk for the developing brain? ...
Borna disease virus 1). Find diseases associated with this biological target and compounds tested against it in bioassay ...
We reviewed recent advances in Borna disease virus research, focusing on evidence of infection in humans. ... The virus has not been clearly linked to any human disease; however, an association between infection with the virus and ... Borna disease virus, a newly classified nonsegmented negative-strand RNA virus with international distribution, infects a broad ... Serum immunoreactivity to Borna disease virus in various diseases *Table 2. Borna disease virus nucleic acid in patients with ...
Persistent Borna Disease Virus infection changes expression and function of astroglial gap junctions in vivo and in vitro.. ... Neonatal Borna Disease Virus (BDV) infection of the Lewis rat brain leads to dentate gyrus (DG) degeneration, underlying ...
... with specific interests in virus infection and human neuropsychiatric diseases. The establishment of sensitive immunoassays ... The study of Borna disease virus (BDV) and BD has broad impact on diverse areas of biology and medicine, notably on molecular ... Home / Books / Borna Disease Virus and Its Role in Neurobehavior... / Chapter 1 : Borna Disease Virus: Spanning a Century of ... Borna Disease Virus: Spanning a Century of Science, p 1-21. In Carbone K (ed), Borna Disease Virus and Its Role in ...
Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. The virus has not been classified because ... A borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases ... A borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases ... A borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases ...
Borna disease, is caused by a virus which damages the nervous system. It has been known in horses in Germany and surrounding ... Borna Disease. (536) Borna disease, is caused by a virus which damages the nervous system. It has been known in horses in ...
Besides its significance for the practitioner, Boma disease virus infection remains to be unique as a disease model: it allows ... Abstract: Boma Disease virus grows without any cytopathic effect in many cell lines (including those from man). It comprises an ... Histopathologically, Boma disease often goes along with a non-purulent inflammation of the brain and the spinal cord. Most ... The diagnosis of Boma disease is established intra vitam on the basis of the clinical symptoms and the presence of antibodies ...
One salient example is the X protein of Borna disease virus, which is expressed both at the mitochondria and in the nucleus. ... Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and ... Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and ...
... can impair neuronal function and lead to neurobehavioral disease are not well understood. To analyze the electrophysiological ... Abstract : The mechanisms whereby Borna disease virus (BDV) can impair neuronal function and lead to neurobehavioral disease ... Borna disease virus infection impairs synaptic plasticity. Romain Volmer 1 Christine Prat 1 Gwendal Le Masson 2 André Garenne 2 ... Borna disease virus infection impairs synaptic plasticity.. Journal of Virology, American Society for Microbiology, 2007, 81 ( ...
Borna disease virus: Et ætiologisk agens ved neuropsykiatriske lidelser?. In: Ugeskrift for Læger. 1997 ; Vol. 159, No. 25. pp ... Borna disease virus: Et ætiologisk agens ved neuropsykiatriske lidelser? Ugeskrift for Læger. 1997;159(25):3930-3933. ... Christensen, L. S. (1997). Borna disease virus: Et ætiologisk agens ved neuropsykiatriske lidelser? Ugeskrift for Læger, 159(25 ... Christensen, LS 1997, Borna disease virus: Et ætiologisk agens ved neuropsykiatriske lidelser?, Ugeskrift for Læger, vol. 159 ...
Implication of a cis-acting element in the cytoplasmic accumulation of unspliced Borna disease virus RNAs.. P A Schneider, M ... Borna disease virus (BDV), the prototype of a new family within the order Mononegavirales, is unusual in its nuclear ... Implication of a cis-acting element in the cytoplasmic accumulation of unspliced Borna disease virus RNAs. ... Implication of a cis-Acting Element in the Cytoplasmic Accumulation of Unspliced Borna Disease Virus RNAs ...
Modeling Borna Disease Virus In Vitro Spread Reveals the Mode of Antiviral Effect Conferred by an Endogenous Bornavirus-Like ... Modeling Borna Disease Virus In Vitro Spread Reveals the Mode of Antiviral Effect Conferred by an Endogenous Bornavirus-Like ... Modeling Borna Disease Virus In Vitro Spread Reveals the Mode of Antiviral Effect Conferred by an Endogenous Bornavirus-Like ... Modeling Borna Disease Virus In Vitro Spread Reveals the Mode of Antiviral Effect Conferred by an Endogenous Bornavirus-Like ...
"Neuron-glia interactions in the rat retina infected by Borna disease virus, Archives of Virology" on DeepDyve, the largest ... Neuron-glia interactions in the rat retina infected by Borna disease virus. Kacza, J.; Vahlenkamp, T. W.; Enbergs, H.; Richt, J ... Neuron-glia interactions in the rat retina infected by Borna disease virus Kacza, J.; Vahlenkamp, T. W.; Enbergs, H.; Richt, J ... lp/springer_journal/neuron-glia-interactions-in-the-rat-retina-infected-by-borna-disease-5TtL5rNknO ...
"Experimental vertical transmission of Borna disease virus in the mouse, Archives of Virology" on DeepDyve, the largest online ... Experimental vertical transmission of Borna disease virus in the mouse. Experimental vertical transmission of Borna disease ... Summary. We demonstrated the experimental vertical transmission of Borna. disease virus (BDV) in pregnant BALB/c mice. Giessen ... Experimental vertical transmission of Borna disease virus in the mouse. Okamoto, M.; Hagiwara, K.; Kamitani, W.; Sako, T.; ...
Borna disease virus (BDV) is a non-segmented, negative-strand RNA virus that replicates and transcribes its genome in the ... Authentic Borna disease virus transcripts are spliced less efficiently than cDNA-derived viral RNAs. Author(s):. Jehle, ... Borna disease virus (BDV) is a non-segmented, negative-strand RNA virus that replicates and transcribes its genome in the ... Christian Jehle, W. Ian Lipkin, Peter Staeheli, Rosa M. Marion, Martin Schwemmle, 2000, Authentic Borna disease virus ...
Cell-to-cell spread of Borna disease virus proceeds in the absence of the virus primary receptor and furin-mediated processing ... Borna disease virus induced meningoencephalomyelitis caused by a virus specific cd4 positive t cell mediated immune reaction. ... N-terminal domain of Borna disease virus G (p56) protein is sufficient for virus receptor recognition and cell entry. Journal ... Borna disease virus induces acute fatal neurological disorders in neonatal gerbils without virus- and immune-mediated cell ...
Detection of antibodies against Borna disease virus in sera and cerebrospinal fluid of horses in the USA ... Detection of antibodies against Borna disease virus in sera and cerebrospinal fluid of horses in the USA ...
The geographic distribution and host range of Borna disease (BD), a fatal neurologic disease of horses and sheep, are larger ... Borna disease virus (BDV) is the causative agent of severe T-cell-mediated meningoencephalitis in horses, sheep, and other ... Borna disease virus, a newly classified nonsegmented negative-strand RNA virus with international distribution, infects a broad ... The etiologic agent, Borna disease virus (BDV), has been identified as an enveloped nonsegmented neg... ...
ANSWER: It could be Borna Disease which has also been called: Sad Horse Disease Staggering Cat Disease Wobbly Possum Disease ... The disease, and its causative virus, are named after BORNA, a town in Germany, where it was first described in 1766, affecting ... I hear you also have a dynamite HOLISTIC HEALING SECRETS FOR HUMANS course, fifty files long? Heal any disease, prevent any ... Borna virus has been isolated from patients with mood disorders, and there is evidence of a new human virus infection possibly ...
... on infection and maintenance of persistent infection of Borna disease (BD) virus in cell cultures was investigated. Acutely BD ... Influence of Interferon on Persistent Infection Caused by Borna Disease Virus in vitro * F. von Rheinbaben, L. Stitz and R. ... The effect of interferon (IFN) on infection and maintenance of persistent infection of Borna disease (BD) virus in cell ...
Borna Disease in a Free-Ranging Lynx (Lynx lynx): A free-ranging lynx (Lynx lynx) was shot because of its abnormal behavior. ... Borna Disease in a Free-Ranging Lynx (Lynx lynx). Authors * M.-P. Degiorgis ... In situ hybridization, immunohistochemistry, and reverse transcriptase PCR analysis showed the presence of Borna disease virus ... To our knowledge, this is the first confirmed case of Borna disease in a large felid. ...
Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection. Brain Research Bulletin. ... Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection. / Bautista, Jan R.; Schwartz ... Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), with ... N2 - Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), ...
BDV infection produces a range of phenotypic disease expression. BDV has a non-segmented, negative-stranded (NNS) RNA genome. ... Borna disease virus (BDV) infectivity and RNA have been detected in bodily secretions and excretions, suggesting that BDV can ... Natural and experimental Borna disease in animals, p. 17- 30. In H. Koprowski, and W. I. Lipkin (ed.), Borna Disease. Springer- ... Borna disease-neuropathology and pathogenesis, p. 39- 74. In H. Koprowski, and W. I. Lipkin (ed.) , Borna Disease Virus. ...
... prevention and eradication of Borna disease in cattle. ... Borna disease in cattle (consensus report)].}, author={Meinolf ... Borna disease in cattle (consensus report)].. @article{Stber1999BornaDI, title={[ ... prevention and eradication of Borna disease in cattle. ...
  • HIV/AIDS and Borna Disease Virus (BDV) in animals help to bring the infection-based model of schizophrenia to the realm of scientific imagination Viruses can influence the human genome. (thefreedictionary.com)
  • In The Neurobiology of Autism (Bauman and Kemper 2005), the authors draw parallels in neurobiology and behavior with autism and another type of infection, neonatal Borna disease virus. (thefreedictionary.com)
  • Following infection, individuals may develop Borna disease, or may remain subclinical, possibly acting as a carrier of the virus. (wikipedia.org)
  • There is some evidence that there may be a relationship between BoDV-1 infection and psychiatric disease. (wikipedia.org)
  • Borna disease virus infection in Italian children. (ingentaconnect.com)
  • We reviewed recent advances in Borna disease virus research, focusing on evidence of infection in humans. (cdc.gov)
  • An olfactory route for transmission has been proposed because intranasal infection is efficient, and the olfactory bulbs of naturally infected horses show inflammation and edema early in the course of disease ( 19 , 20 ). (cdc.gov)
  • Persistent Borna Disease Virus infection changes expression and function of astroglial gap junctions in vivo and in vitro. (nih.gov)
  • Neonatal Borna Disease Virus (BDV) infection of the Lewis rat brain leads to dentate gyrus (DG) degeneration, underlying mechanisms are not fully understood. (nih.gov)
  • The research interest in BDV moved to include Asia in the middle of the 1980s, with specific interests in virus infection and human neuropsychiatric diseases. (asmscience.org)
  • The direct effects and mechanisms of BDV infection on brain dysfunction, in the absence of immunopathological brain injury, need to be determined for a better understanding of BD pathogenesis but also for a better understanding of the links between BDV, human infection, and noninflammatory neuropsychiatric diseases. (asmscience.org)
  • Besides its significance for the practitioner, Boma disease virus infection remains to be unique as a disease model: it allows to study most diverse alterations in neurobiological processes. (scialert.net)
  • Borna disease virus infection impairs synaptic plasticity. (inserm.fr)
  • The effect of interferon (IFN) on infection and maintenance of persistent infection of Borna disease (BD) virus in cell cultures was investigated. (microbiologyresearch.org)
  • In situ hybridization, immunohistochemistry, and reverse transcriptase PCR analysis showed the presence of Borna disease virus infection in the brain. (mysciencework.com)
  • Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), with no signs of encephalitis or Borna disease. (elsevier.com)
  • BDV infection produces a range of phenotypic disease expression. (asmscience.org)
  • Neonatal Borna Disease Virus (BDV) infection in rats leads to a neuronal loss in the cortex, hippocampus and cerebellum. (biomedcentral.com)
  • Borna disease virus infection is diagnosed by the presence of serum antibodies reactive with the major viral proteins, p40 and p23. (mysciencework.com)
  • Carbone, K. M. / Hematologic consequences of Borna disease virus infection of rat bone marrow and thymus stromal cells . (elsevier.com)
  • The progression of a clinically manifested infection is lethal (duration of the disease usually 1 - 3 weeks). (laboklin.com)
  • Definitive diagnosis of Borna virus infection on a live horse is difficult. (petmd.com)
  • Borna disease virus (BDV) infection in horses either occurs as persistent infection without any clinical symptoms, or is associated with various clinical entities. (fu-berlin.de)
  • Whether Borna disease virus (BDV-1) is a human pathogen remained controversial until recent encephalitis cases showed BDV-1 infection could even be deadly. (biomedcentral.com)
  • Infection of newborn Lewis rats with Borna disease virus (neonatal Borna disease [NBD]) results in cerebellar damage without the cellular inflammation associated with infections in later life. (biomedsearch.com)
  • Borna disease appears as a sporadic infection affecting small numbers of animals each year. (cdc.gov)
  • Borna disease virus infection of adult and neonatal rats: models for neuropsychiatric disease. (medigraphic.com)
  • Ludwig H, Bode L. Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology. (medigraphic.com)
  • Varied prevalence of Borna disease virus infection in Arabic, thoroughbred and their cross-bred horses in Iran. (medigraphic.com)
  • abstract = "Borne disease virus (BDV) was previously believed to have a strict tropism for the nervous system. (elsevier.com)
  • Before this discovery, the family Bornaviridae contained only 1 species, Borna disease virus (BDV). (thefreedictionary.com)
  • Borna disease viruses 1 and 2 are neurotropic viruses and members of the Bornaviridae family within the Mononegavirales order. (wikipedia.org)
  • The Borna virus is a non-segmented, enveloped RNA virus which constitutes the only member of the family Bornaviridae. (laboklin.com)
  • Avian bornavirus (ABV) is a newly discovered member of the family Bornaviridae that has been associated with the development of a lethal neurologic syndrome in birds, termed proventricular dilatation disease (PDD). (cdc.gov)
  • Borna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. (nel.edu)
  • Borna disease, also known as sad horse disease, is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease viruses 1 and 2 (BoDV-1/2), both of which are members of the species Mammalian 1 orthobornavirus. (wikipedia.org)
  • Although Borna disease viruses 1 and 2 are mainly seen as the causative agent of Borna disease in horses and other animals, they are also controversially discussed as human infectious agents and therefore as potential zoonotic agents. (wikipedia.org)
  • Borna diseases viruses 1 and 2 appear to have wide host ranges, having been detected in horses, cattle, sheep, dogs and foxes. (wikipedia.org)
  • Avian bornaviruses, a group of related viruses, have been reported, yet not proven, as the cause of proventricular dilatation disease (PDD), a disease of pet parrots. (wikipedia.org)
  • The Borna disease viruses 1 and 2 (BoDV-1 and BoDV-2) are members of the species Mammalian 1 orthobornavirus and cause Borna disease in mammals. (wikipedia.org)
  • Avian Borna viruses are RNA viruses which show high genetic divergence. (laboklin.com)
  • Due to the fact that this would be a first incidence of a previously unknown disease, there is no definitive method of testing for VSBV-1, or for Borna disease viruses in humans. (healthmap.org)
  • The novel VSBV-1 was found to be a phylogenetically unique lineage from previously described Borna disease viruses (1). (healthmap.org)
  • No Borna viruses were detected in the other shrew species. (uni-protokolle.de)
  • Other classifications are determined by the disease caused by the virus or its morphology, neither of which are satisfactory due to different viruses either causing the same disease or looking very similar. (wikidoc.org)
  • Family of double-stranded DNA viruses with icosahedral symmetry, usually found in the respiratory tract of the host species and often associated with respiratory diseases. (citizendium.org)
  • Viruses of the Parvoviridae family, that contain DNA in an icosahedral protein shell and cause disease in many vertebrates, especially mammals such as dogs and cattle. (citizendium.org)
  • Implication of a cis-acting element in the cytoplasmic accumulation of unspliced Borna disease virus RNAs. (asm.org)
  • This virus triggers the co-called Borna disease in mammals and the proventricular dilatation disease in birds. (laboklin.com)
  • and proventricular dilatation disease in birds. (wikipedia.org)
  • Recent discoveries to diagnose BDV-infections intra vitam indicate blood mononuclear cells (PBMCs) to play a key-role in pathogenesis of disease symptoms of horses and man. (fu-berlin.de)
  • Gosztonyi G, Ludwig H. Borna disease--neuropathology and pathogenesis. (medigraphic.com)
  • We also report the association between BDV in the thymus with the lack, or loss, of encephalitis in neonatally inoculated rats or adult-inoculated rats during the chronic stage of disease. (elsevier.com)
  • Identification of differentially expressed genes in brains of newborn Borna disease virus-infected rats in the absence of inflammation. (uniklinik-freiburg.de)
  • Neutralizing antibodies in Borna disease virus-infected rats. (medigraphic.com)
  • Borna disease virus was named after the town of Borna in Saxony, southeastern Germany, where in 1885 many horses in a German cavalry regiment died of a fatal neurologic disease. (thefreedictionary.com)
  • The virus name is derived from the town of Borna in Saxony, Germany, which suffered an epidemic of the disease in horses in 1885. (wikipedia.org)
  • Its name derives from the city in Saxony where the condition was first described in 1894, but the disease occurs in europe , N. africa , and the Near East. (lookfordiagnosis.com)
  • In 2015, German officials reported a cluster of three acute fatal encephalitis cases in the Saxony-Anhalt region to the Early Warning and Response System of the European Center for Disease Control (ECDC) (4). (healthmap.org)
  • The viral family is named after the city of Borna in Saxony, Germany, which is where a large number of animals were lost to the sporadic encephalopathy caused by the viral disease. (wikipedia.org)
  • Characterization of the Borna disease virus phosphoprotein, p2. (mysciencework.com)
  • CiteSeerX - Borna Disease Virus Phosphoprotein Represses p53-Mediated. (yasni.com)
  • Modulation of Borna Disease Virus Phosphoprotein Nuclear Localization. (yasni.com)
  • It has been reported that the Borna disease virus (BDV) encoded phosphoprotein (P protein) can inhibit the activity of Traf family member-associated NF-kappaB activator (TANK)-binding kinase 1 (TBK-1), thus preventing the induction of type I interferon (IFN). (ovid.com)
  • Characterization of the major nuclear localization signal of the Borna disease virus phosphoprotein. (microbiologyresearch.org)
  • Active Borna Disease Virus polymerase complex requires a distinct nucleoprotein-to-phosphoprotein ratio but no viral X protein. (uniklinik-freiburg.de)
  • Proventricular dilatation disease (PDD) is a suspected viral disease that has been given many other names over the years, including macaw wasting disease (as it was thought to be prevalent in this species), neuropathic ganglioneuritis, and lymphoplasmocytic ganglioneuritis. (avianavenue.com)
  • Borna is a viral disease that occurs in horses (and other warm-blooded animals). (petmd.com)
  • A viral disease transmitted by mosquitoes and is endemic in tropical and subtropical regions. (citizendium.org)
  • In this study, we experimentally and theoretically investigated the dynamics of how an extant bornavirus, Borna disease virus 1 (BoDV-1), spreads and replicates in uninfected, BoDV-1-infected, and itEBLN-expressing cultured cells. (asm.org)
  • Prior to this, Bornavirus species were not thought to be responsible for human diseases. (wikipedia.org)
  • Emerging Infectious Diseases , 15 (9), 1452. (cdc.gov)
  • Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential. (sigmaaldrich.com)
  • One salient example is the X protein of Borna disease virus, which is expressed both at the mitochondria and in the nucleus. (sigmaaldrich.com)
  • Borna disease virus (BDV)-encoded P protein inhibited miR-155 expression. (ovid.com)
  • Phosphorylates Borna disease virus (BDV) P protein. (abcam.com)
  • The most common causes for viral encephalitis in sheep include maedi-visna virus, Borna disease virus, and rabies virus. (thefreedictionary.com)
  • Borna disease (BD) is a fatal neurologic disorder in horses and sheep. (thefreedictionary.com)
  • citation needed] Borna disease in sheep and horses arises after a four-week incubation period followed by the development of immune-mediated meningitis and encephalomyelitis. (wikipedia.org)
  • Originally described as a disease of horses, Borna disease has also been found in sheep, llamas, ostriches, cats, and cattle (15) . (cdc.gov)
  • Borna disease in naturally infected horses and sheep is characterized by agitated aggressive behavior that progresses over weeks to paralysis and inanition (29) . (cdc.gov)
  • Because its immune-mediated disease most closely resembles that in naturally infected horses and sheep, the Lewis rat has been selected as a rodent model. (cdc.gov)
  • Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. (sciencemag.org)
  • BoDV-1, which has long been known as the causative agent of Borna disease in horses, sheep and other mammals, was first identified as the cause of severe human encephalitis in 2018. (idw-online.de)
  • It is of clinical relevance particularly in horses, in cats (where the disease is also called "staggering disease") and in sheep. (laboklin.com)
  • this disease has been reported for over two centuries ago in horses, sheep and cats in Central Europe and some regions of Asia. (scirp.org)
  • Bornaviruses are known to cause a lethal form of encephalitis, called borna disease, in horses and sheep. (thehorse.com)
  • A similar disease had been observed in horses, sheep, and cattle for more than 100 years. (cdc.gov)
  • BoDV-1 is known to cause neurological disease in horses and sheep mainly in South and Central Germany. (rki.de)
  • A cinematograph film of Borna disease was shown and it was stated that this virus disease is transmissible to the rabbit, guineapig, rat, fowl, sheep, bovine and horse. (cabi.org)
  • The Borna disease named after the German city of Borna, which saw a cluster of cases over 100 years ago mainly affects horses and sheep, and in rare cases cattle and rabbits too. (uni-protokolle.de)
  • Bornaviruses cause a lethal form of encephalitis, called Borna disease, among horses and sheep. (vetmeduni.ac.at)
  • BDV causes a neurologic syndrome, Borna disease, which is restricted to central Europe, where it is found primarily in horses and sheep. (cdc.gov)
  • Vahlenkamp TW, Konrath A, Weber M, Muller H. Persistence of Borna disease virus in naturally infected sheep. (medigraphic.com)
  • Lundgren AL, Czech G, Bode L, Ludwig H. Natural Borna disease in domestic animals others than horses and sheep. (medigraphic.com)
  • The disease has been identified in a wide variety of birds, including 80 species of psittacines, toucans, honey creepers, weaver finches, water fowl, raptors and passerines. (avianavenue.com)
  • It is considered a serious disease because many of these birds are highly endangered, and several affected species depend on captive breeding for their survival. (cdc.gov)
  • Virus of the Mononegavirales species that causes Borna disease. (citizendium.org)
  • Species of the genus Orthohepadnavirus , characterized by the causing the disease Hepatitis B, which can also lead to cirrhosis and hepatocellular carcinoma, and is transmitted by contaminated blood or blood derivatives. (citizendium.org)
  • Borna disease virus (BDV) is an evolutionary old RNA virus, which infects brain and blood cells of humans, their primate ancestors, and other mammals. (biomedcentral.com)
  • Although Borna disease was first recognized in the early 1800s as a neurologic syndrome with an infectious basis, Borna disease virus (BDV) has only recently been characterized as the causative agent. (cdc.gov)
  • A Bayesian analysis of Borna disease virus 1 suggests that the current strains diversified ~300 years ago and that avian-host bornaviruses evolved considerably earlier than this. (wikipedia.org)
  • Fatal Encephalitis Associated with Borna Disease Virus 1. (nih.gov)
  • The role of BoDV-1 and -2 in human illness is controversial and it is yet to be established whether BoDV-1 or -2 cause any overt disease in humans. (wikipedia.org)
  • Borna virus has been detected in humans, and researchers have presented evidence connecting these infections with psychiatric disorders. (wikipedia.org)
  • Borna disease virus (BDV) is a noncytolytic, neurotropic RNA virus that has a broad host range in warm-blooded animals, probably including humans. (fujita-hu.ac.jp)
  • Borna disease virus-1 (BoDV-1) was recently discovered as cause of severe and often fatal encephalitis in humans. (rki.de)
  • Counter-claims state that Borna virus infections are not cleared by amantadine. (wikipedia.org)
  • The ability of Boma disease virus to cause persistent infections of neurons most probably plays the key role in pathogenetic events. (scialert.net)
  • The study published today in the renowned medical journal „The Lancet Infectious Diseases" collects and characterizes known human infections with Borna Disease Virus (BoDV-1). (idw-online.de)
  • The hypothesis that microbial infections may be linked to mental disorders has long been addressed for Borna disease virus (BDV), but clinical and epidemiological evidence remained inconsistent due to non-conformities in detection methods. (beds.ac.uk)
  • This document assesses the risk associated with the outbreak of Zika virus infections, considered as an emerging disease, to public health in the EU/EEA and the risk to EU/EEA citizens in order to anticipate future developments. (europa.eu)
  • Viral Infections and Global Change is an indispensable resource for research scientists, epidemiologists, and medical and veterinary students working in ecology, environmental management, climatology, neurovirology, virology, and infectious disease. (wiley.com)
  • Bode L, Riegel S, Lange W, Ludwig H. Human infections with Borna disease virus: seroprevalence in patients with chronic diseases and healthy individuals. (medigraphic.com)
  • Bode L, Durrwald R, Ludwig H. Borna virus infections in cattle associated with fatal neurological disease. (medigraphic.com)
  • In 2008, identification of the previously unknown avian Borna virus (ABV) in birds infected with PDD was achieved for the first time. (laboklin.com)
  • We will speak about Avian Borna Virus in an upcoming section). (avianavenue.com)
  • Seeger, J. 2000-01-01 00:00:00 Neuron-glia interactions in the Borna disease virus (BDV)-infected rat retina were investigated with emphasis on the ultrastructural characterization of degenerative alterations in the ganglion cell and photoreceptor layer. (deepdyve.com)
  • Borna disease virus, a newly classified nonsegmented negative-strand RNA virus with international distribution, infects a broad range of warm-blooded animals from birds to primates. (cdc.gov)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • Saving Lives, Protecting People Centers for Disease Control and Prevention. (cdc.gov)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Borna disease was first described in 1885 as "heated head disease" of cavalry horses in 1885 in the town of Borna, Germany. (wikipedia.org)
  • It was first described as the causative agent of a neurologic disease outbreak among horses in the German town of Borna in the 1800s (4, 8). (healthmap.org)
  • The virus infects neurons and astrocytes, and the resulting disease appears to be mediated by an immunopathologic response of the host to the virus. (cdc.gov)
  • The diagnosis of Boma disease is established intra vitam on the basis of the clinical symptoms and the presence of antibodies in serum or cerebrospinal fluid (CSF), as well as by new ELISA methods measuring specific antigen and immune complexes. (scialert.net)
  • Four strains of BDV have been described: Borna V, Borna HE/80, Borna No/98 and Borna H1766. (scirp.org)
  • Strain H1766 has 95% - 98% homology with strains V and He/80, and only 81% with Borna No/98. (scirp.org)
  • At the psychological level, we describe the ways in which the pandemic can affect mating behavior, cooperation (or the lack thereof), and gender norms, and how we can use disgust to better activate native "behavioral immunity" to combat disease spread. (pnas.org)
  • Sprankel H, Richarz K, Ludwig H, Rott R. Behavior alterations in tree shrews (Tupaia glis, Diard 1820) induced by Borna disease virus. (medigraphic.com)
  • Borna disease virus (BDV) is a non-segmented, negative-strand RNA virus that replicates and transcribes its genome in the nucleus of infected cells. (columbia.edu)
  • The article The bicolored white-toothed shrew Crocidura leucodon (HERMANN 1780) is an indigenous host of mammalian Borna disease virus by Ralf D rrwald, Jolanta Kolodziejek, Herbert Weissenb ck and Norbert Nowotny was published on the 3rd of April in the Journal PLOS ONE. (uni-protokolle.de)
  • Borna disease virus (BDV), the prototype of a new family within the order Mononegavirales, is unusual in its nuclear localization for replication and transcription and use of RNA splicing for gene expression. (asm.org)
  • Borna disease virus (BDV) is an enveloped virus with a nonsegmented negative-strand RNA genome whose organization is characteristic of Mononegavirales. (eurekamag.com)
  • Diseases associated with CKM include Prostate Rhabdomyosarcoma and Dressler's Syndrome . (genecards.org)
  • Ashash E, Malkinson M, Meir R, Perl S, Weisman Y. Causes of losses including a Borna disease paralytic syndrome affecting young ostriches of one breeding organization over a five-year period (1989-1993). (medigraphic.com)
  • Borna disease in the horse gives rise to signs like: Unusual posture, gait and ear positions Movement Disturbances (principally ataxia or excess movement) The mode of transmission of BoDV-1/2 is unclear but probably occurs through intranasal exposure to contaminated saliva or nasal secretions. (wikipedia.org)
  • The bicoloured shrew (Crocidura leucodon) lives exclusively in Central Europe, the region where the Borna disease occurs. (uni-protokolle.de)
  • Since then, there have been conflicting results from various studies in regards to whether an association exists between the agent and clinical disease. (wikipedia.org)
  • The clinical signs of Borna virus are similar to other equine encephalitic diseases. (petmd.com)
  • There is no evidence that the donor had any clinical manifestation of the disease. (europa.eu)
  • However, it is possible to get very similar clinical and clinicopathologic symptoms with other diseases, some of which may still have to be classified. (vetstream.com)
  • The impact of Borna Disease virus (BDV) in Asian psychiatric patients remains to be clear. (org.ir)
  • Borna disease virus circulating immunocomplex positivity and psychopathology in psychiatric patients in the Czech Republic. (nel.edu)

No images available that match "borna disease"