Bordetella pertussis. Medical search

A species of gram-negative, aerobic bacteria that is the causative agent of WHOOPING COUGH. Its cells are minute coccobacilli that are surrounded by a slime sheath.

A genus of gram-negative, aerobic bacteria whose cells are minute coccobacilli. It consists of both parasitic and pathogenic species.

A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)

Infections with bacteria of the genus BORDETELLA.

A species of BORDETELLA that is parasitic and pathogenic. It is found in the respiratory tract of domestic and wild mammalian animals and can be transmitted from animals to man. It is a common cause of bronchopneumonia in lower animals.

A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.

A set of BACTERIAL ADHESINS and TOXINS, BIOLOGICAL produced by BORDETELLA organisms that determine the pathogenesis of BORDETELLA INFECTIONS, such as WHOOPING COUGH. They include filamentous hemagglutinin; FIMBRIAE PROTEINS; pertactin; PERTUSSIS TOXIN; ADENYLATE CYCLASE TOXIN; dermonecrotic toxin; tracheal cytotoxin; Bordetella LIPOPOLYSACCHARIDES; and tracheal colonization factor.

One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.

A species of BORDETELLA with similar morphology to BORDETELLA PERTUSSIS, but growth is more rapid. It is found only in the RESPIRATORY TRACT of humans.

Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.

One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLYL CYCLASES and hemolysin components.

A species of BORDETELLA isolated from the respiratory tracts of TURKEYS and other BIRDS. It causes a highly contagious bordetellosis.

Vaccines that are produced by using only the antigenic part of the disease causing organism. They often require a "booster" every few years to maintain their effectiveness.

Immunoglobulins produced in a response to BACTERIAL ANTIGENS.

Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.

An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC 4.6.1.1.

A transient increase in the number of leukocytes in a body fluid.

Substances, usually of biological origin, that cause cells or other organic particles to aggregate and stick to each other. They include those ANTIBODIES which cause aggregation or agglutination of particulate or insoluble ANTIGENS.

Proteins isolated from the outer membrane of Gram-negative bacteria.

Proteins found in any species of bacterium.

Combined vaccines consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and an acellular form of PERTUSSIS VACCINE. At least five different purified antigens of B. pertussis have been used in various combinations in these vaccines.

A vaccine consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and whole-cell PERTUSSIS VACCINE. The vaccine protects against diphtheria, tetanus, and whooping cough.

The top portion of the pharynx situated posterior to the nose and superior to the SOFT PALATE. The nasopharynx is the posterior extension of the nasal cavities and has a respiratory function.

Substances elaborated by bacteria that have antigenic activity.

Preparations of pathogenic organisms or their derivatives made nontoxic and intended for active immunologic prophylaxis. They include deactivated toxins. Anatoxin toxoids are distinct from anatoxins that are TROPANES found in CYANOBACTERIA.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The functional hereditary units of BACTERIA.

The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.

Excess of normal lymphocytes in the blood or in any effusion.

Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.

Deoxyribonucleic acid that makes up the genetic material of bacteria.

Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.

Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.

Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)

Thin, hairlike appendages, 1 to 20 microns in length and often occurring in large numbers, present on the cells of gram-negative bacteria, particularly Enterobacteriaceae and Neisseria. Unlike flagella, they do not possess motility, but being protein (pilin) in nature, they possess antigenic and hemagglutinating properties. They are of medical importance because some fimbriae mediate the attachment of bacteria to cells via adhesins (ADHESINS, BACTERIAL). Bacterial fimbriae refer to common pili, to be distinguished from the preferred use of "pili", which is confined to sex pili (PILI, SEX).

The formaldehyde-inactivated toxin of Corynebacterium diphtheriae. It is generally used in mixtures with TETANUS TOXOID and PERTUSSIS VACCINE; (DTP); or with tetanus toxoid alone (DT for pediatric use and Td, which contains 5- to 10-fold less diphtheria toxoid, for other use). Diphtheria toxoid is used for the prevention of diphtheria; DIPHTHERIA ANTITOXIN is for treatment.

The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.

A chronic inflammation in which the NASAL MUCOSA gradually changes from a functional to a non-functional lining without mucociliary clearance. It is often accompanied by degradation of the bony TURBINATES, and the foul-smelling mucus which forms a greenish crust (ozena).

Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.

Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.

An ester formed between the aldehydic carbon of RIBOSE and the terminal phosphate of ADENOSINE DIPHOSPHATE. It is produced by the hydrolysis of nicotinamide-adenine dinucleotide (NAD) by a variety of enzymes, some of which transfer an ADP-ribosyl group to target proteins.

The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.

Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.

Proteins from BACTERIA and FUNGI that are soluble enough to be secreted to target ERYTHROCYTES and insert into the membrane to form beta-barrel pores. Biosynthesis may be regulated by HEMOLYSIN FACTORS.

Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.

Antisera from immunized animals that is purified and used as a passive immunizing agent against specific BACTERIAL TOXINS.

An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.

Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.

Role of antibodies against Bordetella pertussis virulence factors in adherence of Bordetella pertussis and Bordetella parapertussis to human bronchial epithelial cells. (1/1244)

Immunization with whole-cell pertussis vaccines (WCV) containing heat-killed Bordetella pertussis cells and with acellular vaccines containing genetically or chemically detoxified pertussis toxin (PT) in combination with filamentous hemagglutinin (FHA), pertactin (Prn), or fimbriae confers protection in humans and animals against B. pertussis infection. In an earlier study we demonstrated that FHA is involved in the adherence of these bacteria to human bronchial epithelial cells. In the present study we investigated whether mouse antibodies directed against B. pertussis FHA, PTg, Prn, and fimbriae, or against two other surface molecules, lipopolysaccharide (LPS) and the 40-kDa outer membrane porin protein (OMP), that are not involved in bacterial adherence, were able to block adherence of B. pertussis and B. parapertussis to human bronchial epithelial cells. All antibodies studied inhibited the adherence of B. pertussis to these epithelial cells and were equally effective in this respect. Only antibodies against LPS and 40-kDa OMP affected the adherence of B. parapertussis to epithelial cells. We conclude that antibodies which recognize surface structures on B. pertussis or on B. parapertussis can inhibit adherence of the bacteria to bronchial epithelial cells, irrespective whether these structures play a role in adherence of the bacteria to these cells. (+info)

Role of Bordetella pertussis virulence factors in adherence to epithelial cell lines derived from the human respiratory tract. (2/1244)

During colonization of the respiratory tract by Bordetella pertussis, virulence factors contribute to adherence of the bacterium to the respiratory tract epithelium. In the present study, we examined the roles of the virulence factors filamentous hemagglutinin (FHA), fimbriae, pertactin (Prn), and pertussis toxin (PT) in the adherence of B. pertussis to cells of the human bronchial epithelial cell line NCI-H292 and of the laryngeal epithelial cell line HEp-2. Using B. pertussis mutant strains and purified FHA, fimbriae, Prn, and PT, we demonstrated that both fimbriae and FHA are involved in the adhesion of B. pertussis to laryngeal epithelial cells, whereas only FHA is involved in the adherence to bronchial epithelial cells. For PT and Prn, no role as adhesion factor was found. However, purified PT bound to both bronchial and laryngeal cells and as such reduced the adherence of B. pertussis to these cells. These data may imply that fimbriae play a role in infection of only the laryngeal mucosa, while FHA is the major factor in colonization of the entire respiratory tract. (+info)

Characterization of human bactericidal antibodies to Bordetella pertussis. (3/1244)

The Bordetella pertussis BrkA protein protects against the bactericidal activity of complement and antibody; however, some individuals mount an immune response that overcomes this bacterial defense. To further characterize this process, the bactericidal activities of sera from 13 adults with different modes of exposure to B. pertussis (infected as adults, occupational exposure, immunized with an acellular vaccine, or no identified exposure) against a wild-type strain and a BrkA complement-sensitive mutant were evaluated. All of the sera killed the BrkA mutant, suggesting past exposure to B. pertussis or cross-reactive organisms. Several samples had no or minimal activity against the wild type. All of the sera collected from the infected and occupationally exposed individuals but not all of the sera from vaccinated individuals had bactericidal activity against the wild-type strain, suggesting that some types of exposure can induce an immune response that can overcome the BrkA resistance mechanism. Adsorbing serum with the wild-type strain removed the bactericidal antibodies; however, adsorbing the serum with a lipopolysaccharide (LPS) mutant or an avirulent (bvg mutant) strain did not always result in loss of bactericidal activity, suggesting that antibodies to either LPS or bvg-regulated proteins could be bactericidal. All the samples, including those that lacked bactericidal activity, contained antibodies that recognized the LPS of B. pertussis. Bactericidal activity correlated best with the presence of the immunoglobulin G3 (IgG3) antibodies to LPS, the IgG subtype that is most effective at fixing complement. (+info)

Maternal immunization. (4/1244)

Maternal immunization can enhance passive immunity of infants to pathogens that cause life-threatening illnesses. In most instances, immunization during pregnancy will provide important protection for the woman as well as for her offspring. The tetanus toxoid and influenza vaccines are examples of vaccines that provide a double benefit. Other vaccines under evaluation include those for respiratory syncytial virus, pneumococci, group B streptococci, and Haemophilus influenzae type b. Although most IgG antibody crosses the placenta in the third trimester, the process is time-dependent, dictating that immunization should be accomplished ideally at least 6 weeks prior to delivery. IgG1 antibodies are transferred preferentially. Maternal immunization has not interfered with active immunization of the infant. Inactivated vaccines administered in the third trimester of pregnancy pose no known risk to the woman or to her fetus. (+info)

Temporal trends in the population structure of Bordetella pertussis during 1949-1996 in a highly vaccinated population. (5/1244)

The population structure of Bordetella pertussis in The Netherlands in 5 successive periods, encompassing 1949-1996, was analyzed by DNA typing ("fingerprinting"). In 10 years following the introduction of wide-scale vaccination in 1953, a decrease in genotypic diversity (GD) was observed, suggesting clonal expansion of strains that were adapted to vaccine-induced immunity. In subsequent periods, GD increased to prevaccination levels, probably reflecting a gradual adaptation of the B. pertussis population involving many lineages. In the 1990s, GD decreased again. This decrease coincided with an antigenic shift in the surface protein pertactin. No evidence was found for changes in DNA types or GD in 1996, when a large pertussis epidemic occurred. Thus, gradual changes in the bacterial population previous to 1996 were probably the cause of the 1996 epidemic. The results herein suggest that vaccination has selected for strains that are adapted to a highly vaccinated population. Similar changes may have occurred in other countries, explaining the reemergence of pertussis in vaccinated populations. (+info)

Analysis with a combination of macrorestriction endonucleases reveals a high degree of polymorphism among Bordetella pertussis isolates in eastern France. (6/1244)

From 1990 to 1996, routine screening for whooping cough identified 399 patients with a calmodulin-dependent adenylate cyclase-positive test result and yielded 69 Bordetella pertussis isolates. None of the patients were fully vaccinated, and most were less than 6 months old. Analysis of total DNA by pulsed-field gel electrophoresis (PFGE) after XbaI, SpeI, or DraI macrorestriction yielded 19, 15, and 5 different patterns, respectively, whereas ribotyping failed to demonstrate any strain polymorphism. Discrimination among the isolates was improved by combining the PFGE profiles. Some patterns were more frequent, but the corresponding patients were not clearly epidemiologically related. The patterns for two strains obtained during a 3-month period from patients who were neighbors differed by the length of a single DNA fragment. These data strongly suggest that one type of isolate is widely spread throughout the world and is carried by individuals other than patients who develop a true illness. (+info)

Serum IgG antibody responses to pertussis toxin and filamentous hemagglutinin in nonvaccinated and vaccinated children and adults with pertussis. (7/1244)

Levels of IgG antibody to pertussis toxin (PT) and filamentous hemagglutinin (FHA) were measured in paired serum samples from 781 patients fulfilling at least one laboratory criterion for pertussis that was suggested by an ad hoc committee sponsored by the World Health Organization. The patients were participants or family members of participants in a double-blind efficacy trial of a monocomponent pertussis toxoid vaccine. Of 596 nonvaccinated children, 90% had significant (two-fold or more) rises in PT IgG and FHA IgG levels. Only 17 (32%) of 53 children previously vaccinated with three doses of pertussis toxoid had rises in PT IgG levels because they already had elevated PT IgG levels in their acute-phase serum samples. PT IgG and FHA IgG levels were significantly higher in acute-phase serum samples from 29 adults than in acute-phase serum samples from the nonvaccinated children. Nevertheless, significant rises in levels of PT IgG (79% of samples) and FHA IgG (90%) were demonstrated in adults. In conclusion, assay of PT IgG and FHA IgG in paired serum samples is highly sensitive for diagnosing pertussis in nonvaccinated individuals. Assay of PT IgG levels in paired sera is significantly less sensitive for diagnosis of pertussis for children vaccinated with pertussis toxoid. (+info)

The conserved lysine 860 in the additional fatty-acylation site of Bordetella pertussis adenylate cyclase is crucial for toxin function independently of its acylation status. (8/1244)

The Bordetella pertussis RTX (repeat in toxin family protein) adenylate cyclase toxin-hemolysin (ACT) acquires biological activity upon a single amide-linked palmitoylation of the epsilon-amino group of lysine 983 (Lys983) by the accessory fatty-acyltransferase CyaC. However, an additional conserved RTX acylation site can be identified in ACT at lysine 860 (Lys860), and this residue becomes palmitoylated when recombinant ACT (r-Ec-ACT) is produced together with CyaC in Escherichia coli K12. We have eliminated this additional acylation site by replacing Lys860 of ACT with arginine, leucine, and cysteine residues. Two-dimensional gel electrophoresis and microcapillary high performance liquid chromatography/tandem mass spectrometric analyses of mutant proteins confirmed that the two sites are acylated independently in vivo and that mutations of Lys860 did not affect the quantitative acylation of Lys983 by palmitoyl (C16:0) and palmitoleil (cis Delta9 C16:1) fatty-acyl groups. Nevertheless, even the most conservative substitution of lysine 860 by an arginine residue caused a 10-fold decrease of toxin activity. This resulted from a 5-fold reduction of cell association capacity and a further 2-fold reduction in cell penetration efficiency of the membrane-bound K860R toxin. These results suggest that lysine 860 plays by itself a crucial structural role in membrane insertion and translocation of the toxin, independently of its acylation status. (+info)

16: Pertussis Parkhill J, et al. (2003). "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella ... Nieves DJ, Heininger U (2016). "Bordetella pertussis". Bordetella pertussis. Microbiology Spectrum. Vol. 4. pp. 311-339. doi: ... Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus of the genus Bordetella, and the ... "Bordetella pertussis epidemiology and evolution in the light of pertussis resurgence". Infection, Genetics and Evolution. 40: ...

https://en.wikipedia.org/wiki/Bordetella_pertussis

Bordetella pertussis 1. She was a full professor of biomedicine at Mucosal Immunology and Vaccine Center in Gothenburg. ...

https://en.wikipedia.org/wiki/Teresa_Lagergård

... is an adenylate cyclase produced by Bordetella pertussis. Kessin RH, Franke J (April 1986). " ... Ladant D, Brezin C, Alonso JM, Crenon I, Guiso N (December 1986). "Bordetella pertussis adenylate cyclase. Purification, ... "Secreted adenylate cyclase of Bordetella pertussis: calmodulin requirements and partial purification of two forms". J. ...

https://en.wikipedia.org/wiki/Extracellular_adenylate_cyclase

In Bordetella pertussis, the infectious agent in childhood whooping cough, filamentous haemagglutinin (FHA) is a surface- ... "Filamentous hemagglutinin of Bordetella pertussis. A bacterial adhesin formed as a 50-nm monomeric rigid rod based on a 19- ... "Beta-helix model for the filamentous haemagglutinin adhesin of Bordetella pertussis and related bacterial secretory proteins". ... Inatsuka CS, Julio SM, Cotter PA (December 2005). "Bordetella filamentous hemagglutinin plays a critical role in ...

https://en.wikipedia.org/wiki/Haemagglutination_activity_domain

Diseases such as pertussis (or whooping cough) are caused by the bacteria Bordetella pertussis. This bacteria is marked by a ... Yeh, Sylvia H.; Mink, ChrisAnna M. (2012). "Bordetella pertussis and Pertussis (Whooping Cough)". Netter's Infectious Diseases ... The pertussis toxin is a protein exotoxin that binds to cell receptors by two dimers and reacts with different cell types such ... PCR is an important testing tool that can detect sequences within the gene for the pertussis toxin. Because PCR has a high ...

https://en.wikipedia.org/wiki/Polymerase_chain_reaction

2003). "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella ... and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies". Clinical ... 1991). "Effects of Bordetella pertussis infection on human respiratory epithelium in vivo and in vitro". Infection and Immunity ... Luker, K. E.; Collier, J. L.; Kolodziej, E. W.; Marshall, G. R.; Goldman, W. E. (1993). "Bordetella pertussis Tracheal ...

https://en.wikipedia.org/wiki/Tracheal_cytotoxin

... (PT) is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping ... Carbonetti NH (2010). "Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell ... pertussis produces PT and the other species do not. Bordetella parapertussis shows the most similarity to B. pertussis and was ... "Bordetella pertussis population dynamics and phylogeny in Japan after adoption of acellular pertussis vaccines". Microbial ...

https://en.wikipedia.org/wiki/Pertussis_toxin

Corynebacterium diphtheriae and Bordetella pertussis. ubiquitination and SUMOylation Various full-length, folded proteins can ...

https://en.wikipedia.org/wiki/Protein_primary_structure

"Polymorphism in the Bordetella pertussis virulence factors P.69/pertactin and pertussis toxin in The Netherlands: temporal ... "Bordetella pertussis and pertactin-deficient clinical isolates: lessons for pertussis vaccines". Expert Review of Vaccines. 13 ... Kallonen, Teemu; He, Qiushui (2009-07-01). "Bordetella pertussis strain variation and evolution postvaccination". Expert Review ... "Pertactin negative Bordetella pertussis demonstrates higher fitness under vaccine selection pressure in a mixed infection model ...

https://en.wikipedia.org/wiki/Vaccine_resistance

Pertussis is caused by the bacterium Bordetella pertussis. It is spread easily through the coughs and sneezes of an infected ... Pertussis is caused by the bacterium Bordetella pertussis. It is an airborne disease (through droplets) that spreads easily ... Pertussis infection in these persons may be asymptomatic, or present as illness ranging from a mild cough to classic pertussis ... The pertussis vaccine became available in the 1940s. The classic symptoms of pertussis are a paroxysmal cough, inspiratory ...

https://en.wikipedia.org/wiki/Whooping_cough

It is often seen in conjunction with Bordetella pertussis infections (whooping cough), although not always. Weyant, Robbin S.; ... Bordetella holmesii is a Gram-negative, rod-shaped bacterium of the genus Bordetella. It was named in recognition of Barry ... "Transmission of Bordetella holmesii during Pertussis Outbreak, Japan". Emerging Infectious Diseases. 18 (7): 1166-1169. doi: ... "Bordetella holmesii DNA is not detected in nasopharyngeal swabs from Finnish and Dutch patients with suspected pertussis". ...

https://en.wikipedia.org/wiki/Bordetella_holmesii

With Jules Bordet he isolated Bordetella pertussis in pure culture in 1906 and declared it as the cause of whooping cough. In ... He researched with Jules Bordet the Bordetella pertussis bacteria. At the age of 22, he obtained his doctorate at the ... The pertussis endotoxin. Etiologie de la coqueluche. Etat actuel de la question, 1909 - Etiology of pertussis. Current status ... Le Microbe de la coqueluche, 1906 - The microbe "pertussis". Note complémentaire sur le microbe de la coqueluche, 1906 - ...

https://en.wikipedia.org/wiki/Octave_Gengou

... is a highly immunogenic virulence factor of Bordetella pertussis, the bacterium that causes pertussis. Specifically, it is an ... PRN is purified from Bordetella pertussis and is used for the vaccine production as one of the important components of ... Emsley, P.; Charles, I. G.; Fairweather, N. F.; Isaacs, N. W. (1996). "Structure of Bordetella pertussis virulence factor P.69 ... Emsley P, Charles IG, Fairweather NF, Isaacs NW (May 1996). "Structure of Bordetella pertussis virulence factor P.69 pertactin ...

https://en.wikipedia.org/wiki/Pertactin

Bordetella pertussis. Bordetella bronchiseptica and Bordetella parapertussis, also able to cause pertussis-like symptoms, also ... Vaccination against Bordetella pertussis is used in infancy to prevent whooping cough. The recent switch from whole-cell ... Adenylate cyclase toxin is a virulence factor produced by some members of the genus Bordetella. Together with the pertussis ... Adenylate cyclase toxin from Bordetella pertussis is a 1706 amino acid residue long protein. The protein consists of three ...

https://en.wikipedia.org/wiki/Adenylate_cyclase_toxin

"Vaccine Development for the Control of Bordetella Pertussis Infections". Infection and Immunity. 86 (6): e00004-18. doi:10.1128 ...

https://en.wikipedia.org/wiki/List_Biological_Laboratories

"Interaction of human Tamm-Horsfall glycoprotein with Bordetella pertussis toxin". Microbiology. 148 (Pt 4): 1193-1201. doi: ...

https://en.wikipedia.org/wiki/Uromodulin

Guiso N. 2009.Bordetella pertussis and pertussis vaccines. Clin. Infect. Dis. 49:1565-1569 "1.C.72 The Pertussis Toxin (PTX) ... Pertussis toxin is secreted by the gram-negative bacterium, Bordetella pertussis. Whooping cough is very contagious and cases ... Carbonetti, N. H. (2010). "Pertussis toxin and adenylate cyclase toxin: Key virulence factors of Bordetella pertussis and cell ... The bacterium Bordetella pertussis was first identified as the cause of whooping cough and isolated by Jules Bordet and Octave ...

https://en.wikipedia.org/wiki/AB5_toxin

"Human Serum Antibody Responses to Bordetella pertussis Infection and Pertussis Vaccination". The Journal of Infectious Diseases ...

https://en.wikipedia.org/wiki/Harold_Lambert_(physician)

... and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies". Clin ... pertussis) are also motile. B. pertussis and occasionally B. parapertussis cause pertussis or whooping cough in humans, and ... Due to the fact B. pertussis is only found in humans and shows little genetic variation from the other Bordetella species, it ... The three most common species of Bordetella are B. pertussis, B. parapertussis and B. bronchiseptica. These species are known ...

https://en.wikipedia.org/wiki/Bordetella

"The O Antigen Enables Bordetella parapertussis To Avoid Bordetella pertussis-Induced Immunity". Infection and Immunity. 75 (10 ... "Clinical characteristics of illness caused by Bordetella parapertussis compared with illness caused by Bordetella pertussis". ... Bordetella parapertussis is a small Gram-negative bacterium of the genus Bordetella that is adapted to colonise the mammalian ... Pertussis caused by B. parapertussis manifests with similar symptoms to B. pertussis-derived disease, but in general tends to ...

https://en.wikipedia.org/wiki/Bordetella_parapertussis

Bordetella pertussis, Haemophilus influenzae), and some respiratory tract and soft-tissue infections. The antimicrobial ... "Infantile hypertrophic pyloric stenosis after pertussis prophylaxis with erythromcyin: a case review and cohort study". Lancet ...

https://en.wikipedia.org/wiki/Macrolide

Bordetella pertussis is a Gram-negative coccobacillus responsible for causing whooping cough. Yersinia pestis, the bacterium ...

https://en.wikipedia.org/wiki/Coccobacillus

OCLC 630453151.{{cite book}}: CS1 maint: others (link) "Bordetella pertussis toxoid antigen (formaldehyde, glutaraldehyde ...

https://en.wikipedia.org/wiki/Toxoid

Gordon's work focused on pertussis cultures and virulence of the bacterium Bordetella pertussis. Gordon's analysis of pertussis ... Kendrick to support pertussis research at the Michigan Department of Health's Grand Rapids lab around 1944. In the early 1940s ... and the Grand Rapids Pertussis Trials, 1932-1939". Michigan Historical Review. 33 (1): 59-85. doi:10.1353/mhr.2007.0001. JSTOR ... doctors Pearl Kendrick and Grace Eldering with bacteriological virulence research leading to the creation of the pertussis ...

https://en.wikipedia.org/wiki/Loney_Gordon

"CSTE Position Statement 13-ID-15". CDC (NNDSS) Diseases and Conditions - Pertussis / Whooping Cough (Bordetella pertussis) 2014 ...

https://en.wikipedia.org/wiki/Council_of_State_and_Territorial_Epidemiologists

Skerry C, Goldman WE, Carbonetti NH (February 2019). "Bordetella pertussis and Contributes to Sphingosine-1-Phosphate Receptor ... pneumonia associated with impaired bacterial clearance and more severe pulmonary inflammation following Bordetella pertussis ...

https://en.wikipedia.org/wiki/Peptidoglycan_recognition_protein_4

These adenylyl cyclases are toxins secreted by pathogenic bacteria such as Bacillus anthracis, Bordetella pertussis, ... "Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin". The EMBO Journal. 24 (18 ...

https://en.wikipedia.org/wiki/Adenylyl_cyclase

Pertussis is a highly contagious disease that is caused by the bacteria Bordetella pertussis. The bacteria clings to cilia in ... "Pertussis Causes and Transmission". CDC. CDC. Retrieved 10 April 2014. "Pertussis Signs and Symptoms". CDC. CDC. Retrieved 10 ... Unfortunately, the effectiveness of the Pertussis vaccine is dependent on herd immunity, if pertussis is circulating in the ... Pertussis and Tetanus. The DTaP vaccine is given as a 5-shot series at 2, 4, and 6 months, the fourth between 12 and 15 months ...

https://en.wikipedia.org/wiki/Childhood_immunizations_in_the_United_States

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica". ...

https://en.wikipedia.org/wiki/Duncan_Maskell

"The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia coli". Molecular ...

https://en.wikipedia.org/wiki/Antoine_Danchin

One notable bacterium that produces filamentous haemagglutinin adhesin is Bordetella pertussis, which uses this protein as a ... a multifaceted adhesion produced by virulent Bordetella spp". Molecular Microbiology. 9: 653-60. doi:10.1111/j.1365-2958.1993. ...

https://en.wikipedia.org/wiki/Filamentous_haemagglutinin_adhesin

"Mannose receptor and macrophage galactose-type lectin are involved in Bordetella pertussis mast cell interaction". Journal of ...

https://en.wikipedia.org/wiki/Pattern_recognition_receptor

Thoden JB, Holden HM (March 2011). "Biochemical and structural characterization of WlbA from Bordetella pertussis and ...

https://en.wikipedia.org/wiki/UDP-N-acetyl-2-amino-2-deoxyglucuronate_dehydrogenase

Viridans group streptococci Aerobic Gram-negative bacteria Bordetella pertussis Legionella pneumophila Pasteurella multocida ...

https://en.wikipedia.org/wiki/Clarithromycin

... killed bacteria of the species Bordetella pertussis, Mycobacterium bovis,[citation needed] toxoids Plant saponins from Quillaja ...

https://en.wikipedia.org/wiki/Immunologic_adjuvant

Whooping cough, or pertussis, is a contagious respiratory disease caused by the bacteria Bordetella pertussis. It is fatal in ... "Maternal and Neonatal Tetanus Elimination (MNTE)". "Complications of Whooping Cough (Pertussis) , CDC". April 2021. Cohen, ...

https://en.wikipedia.org/wiki/Immunization_during_pregnancy

Baylisascaris procyonis Bordetella pertussis (Pertussis or whooping cough) Chlamydia pneumoniae Chlamydia trachomatis ( ... Klement E, Grotto I, Srugo I, Orr N, Gilad J, Cohent D (March 2005). "Pertussis in soldiers, Israel". Emerging Infect. Dis. 11 ...

https://en.wikipedia.org/wiki/Subclinical_infection

With Octave Gengou, he isolated Bordetella pertussis in pure culture in 1906 and posited it as the cause of whooping cough. He ... The bacterial genus Bordetella is named after him. The Nobel Prize in Physiology or Medicine was awarded to him in 1919 for his ...

https://en.wikipedia.org/wiki/Jules_Bordet

Like Bordetella pertussis, it forms a calmodulin-dependent adenylate cyclase exotoxin known as anthrax edema factor, along with ...

https://en.wikipedia.org/wiki/Bacillus_anthracis

As a result, it enables establishment of Bordetella infection of airway mucosa and promotes immune evasion of B. pertussis, by ... Adenylate cyclase toxin (CyaA) is released from bacterium Bordetella pertussis by the T1SS (Type 1 secretion system) and ... pertussis bacteria that enter into human and murine macrophages by a non-phagocytic mechanism. Pertussis toxin Anthrax toxin ... Sebo P, Osicka R, Masin J (October 2014). "Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines". Expert Review ...

https://en.wikipedia.org/wiki/CyaA

Anaplasmosis Aspergillus BK virus Bordetella pertussis Borrelia miyamotoi Clostridium difficile Cryptococcus gattii ...

https://en.wikipedia.org/wiki/Emerging_infectious_disease

... a bacteriocin active against phase I organisms of Bordetella pertussis. H. pertucinogena was originally assigned to the genus ...

https://en.wikipedia.org/wiki/Halopseudomonas_pertucinogena

Four diseases were responsible for 98% of vaccine-preventable deaths: measles, Haemophilus influenzae serotype b, pertussis, ... Bordetella Canine distemper Canine influenza Canine parvovirus Chlamydia Feline calicivirus Feline distemper Feline leukemia ... pertussis, poliomyelitis, rubella, tetanus, tuberculosis, and yellow fever. The WHO reports licensed vaccines being available ... infection Influenza Japanese encephalitis Malaria Measles Meningococcal disease Monkeypox Mumps Pneumococcal disease Pertussis ...

https://en.wikipedia.org/wiki/Vaccine-preventable_diseases

Bordetella pertussis, Bacillus anthracis, Corynebacterium diphtheriae, Neisseria gonorrhoeae, Chlamydophila pneumoniae, ...

https://en.wikipedia.org/wiki/Pharyngitis

Pertussis toxin (PTx) of Bordetella pertussis, formerly known as lymphocytosis-promoting factor, causes a decrease in the entry ...

https://en.wikipedia.org/wiki/Lymphocyte

Because pertussis is known to be caused by the bacterium Bordetella pertussis, vaccination is effective. A paper co-authored in ... July 2018). "Pertussis Immunisation in Pregnancy Safety (PIPS) Study: A retrospective cohort study of safety outcomes in ... "Pertussis (Whooping Cough)". Centers for Disease Control and Prevention. Archived from the original on 29 December 2021. ... 16 July 2019). "Pertussis Vaccination Failure in the New Zealand Pediatric Population: Study Protocol". Vaccines. 7 (65): 65. ...

https://en.wikipedia.org/wiki/Helen_Petousis-Harris

... and Bordetella pertussis may help prevent it. The management of rhinitis depends on the underlying cause. For allergic rhinitis ...

https://en.wikipedia.org/wiki/Rhinitis

Bordetella pertussis strain lacking pertactin and pertussis toxin. Emerg Infect Dis. 2016 Feb;22(2):319-22. ... Genomic Survey of Bordetella pertussis Diversity in the United States, 2000-2013. Emerg Infect Dis. 2019 Apr;25(4):780-783. ... Pertactin-negative Bordetella pertussis strains: Evidence for a possible selective advantage. Clin Infect Dis. 2015 Jan 15;60( ... The history of Bordetella pertussis genome plasticity and conserved rearrangement. J Bacteriol. 2017 Mar 28: 199(8). ...

https://www.cdc.gov/abcs/reports-findings/pubs-bordetella-pert.html

Laboratory Manual for the diagnosis of whooping cough caused by bordetella pertussis/bordetella parapertussis : update 2014 ... Evaluation of purified monoclonal antibodies to Bordetella pertussis fimbriae type 2 and 3 : study report and proposal to ... evaluation of proposed international standard monoclonal antibodies for serotyping bordetella pertussis fimbrial antigen 2 and ... Pertussis surveillance : a global meeting, Geneva, 16-18 October 2000 World Health Organization (‎World Health ...

https://extranet.who.int/iris/restricted/browse?authority=Bordetella+pertussis&type=mesh

IS481-like element IS481 family transposase [Bordetella pertussis]. NCBI Reference Sequence: WP_010930066.1 ...

https://www.ncbi.nlm.nih.gov/protein/WP_010930066.1

Bordetella pertussis Toxin PT; and Bordetella pertussis Whole-Cell Antigens have been expressly designed for use as integral ... The Bordetella pertussis FHA; Bordetella pertussis Toxin PT; and Bordetella pertussis Whole-Cell Antigens have been expressly ... The Bordetella pertussis FHA; Bordetella pertussis Toxin PT; and Bordetella pertussis Whole-Cell Antigens have been expressly ... Bordetella pertussis is the causative agent of Pertussis, or "Whooping Cough". In addition, Bordetella pertussis also has the ...

https://www.labmanager.com/product-news/binding-site-now-offers-bordetella-pertussis-antigens-for-ivd-manufacturing-research-applications-5396

Bordetella pertussis is a Gram-negative human-restricted bacterium that evolved from the broad-range mammalian pathogen, ... The introduction of the pertussis whole-cell vaccination for young children, followed by the introduction of the pertussis ... Bordetella bronchiseptica. It causes whooping cough or pertussis in humans, which is the most prevalent vaccine-preventable ... B. pertussis is relatively monomorphic worldwide, but nevertheless, different countries are facing different epidemiological ...

https://research.pasteur.fr/en/publication/epidemiology-of-whooping-cough-typing-of-bordetella-pertussis/

Analysis of clinical Bordetella pertussis isolates using whole genome sequences reveals novel genomic regions associated with ... Analysis of clinical Bordetella pertussis isolates using whole genome sequences reveals novel genomic regions associated with ... Background: Despite high-levels of vaccination, whooping cough, primarily caused by Bordetella pertussis (BP), has persisted ... Analysis of clinical Bordetella pertussis isolates using whole genome sequences reveals novel genomic regions associated with ...

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More Details about Anti-B. pertussis Toxin IgG Related Product. Anti-B. pertussis Toxin IgG. Anti-B. pertussis Toxin IgG is is ... Launch Diagnostics is a licensed reseller and distributor of Bordetella pertussis IgG. Launch Diagnostics is the largest ... an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against pertussis toxin in ...

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Bordetella pertussis Strain Lacking Pertactin and Pertussis Toxin Cite CITE. Title : Bordetella pertussis Strain Lacking ... A Bordetella pertussis strain lacking 2 acellular vaccine immunogens, pertussis toxin and pertactin, was isolated from an ... Rapid Increase in Pertactin-deficient Bordetella pertussis Isolates, Australia Cite CITE. Title : Rapid Increase in Pertactin- ... Title : Bordetella pertussis, Finland and France Personal Author(s) : Caro, Valérie;Elomaa, Annika;Brun, Delphine;Mertsola, ...

https://stacks.cdc.gov/view/cdc/16107

Bordetella pertussis) case definitions; uniform criteria used to define a disease for public health surveillance. ... Pertussis / Whooping Cough (Bordetella pertussis) , Revised May 2, 1997. *Pertussis / Whooping Cough (Bordetella pertussis) , ... Pertussis (Whooping Cough) (Bordetella pertussis) , 2020 Case Definition. *Pertussis / Whooping Cough (Bordetella pertussis) , ... Pertussis / Whooping Cough (Bordetella pertussis) , 1996 Case Definition. *Pertussis / Whooping Cough (Bordetella pertussis) , ...

https://ndc.services.cdc.gov/?p=126706

Contributions of the Hydrophobic Helix 2 of the Bordetella pertussis CyaA-hemolysin to Membrane Permeabilization ... "Contributions of the Hydrophobic Helix 2 of the Bordetella pertussis CyaA-hemolysin to Membrane Permeabilization" , in Protein ...

https://fodok.uni-linz.ac.at/fodok/publikation.xsql?PUB_ID=63501

The Bordetella pertussis toxin (PT) Antibody (IgG), Im Quest lab test contains 1 test with 1 biomarker. ... Bordetella pertussis toxin (PT) Antibody (IgG), Im The Bordetella pertussis toxin (PT) Antibody (IgG), Im test contains 1 test ... Bordetella pertussis toxin (PT) Antibody (IgG), Immunoassay #37295 1 Biomarkers - Average Process Time*: 4 to 5 days ...

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A truncated Bordetella pertussis cya gene product was expressed in Escherichia coli and purified by affinity chromatography on ... Isolation and characterization of catalytic and calmodulin-binding domains of Bordetella pertussis adenylate cyclase. Hélène ... Abstract : A truncated Bordetella pertussis cya gene product was expressed in Escherichia coli and purified by affinity ... Isolation and characterization of catalytic and calmodulin-binding domains of Bordetella pertussis adenylate cyclase.. European ...

https://hal-pasteur.archives-ouvertes.fr/pasteur-00167100

CDC-recommended first-line tests for pertussis are Bordetella pertussis/parapertussis by PCR (0065080) and/or Bordetella ... pertussis Culture (0060117). In most cases, serology testing is not recommended for the diagnosis of active pertussis infection ... If Bordetella pertussis Antibody, IgG by ELISA is 1.05 IV or greater, then Bordetella pertussis IgG Immunoblot testing will be ... CDC-recommended first-line tests for pertussis are Bordetella pertussis/parapertussis by PCR (0065080) and/or Bordetella ...

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Bordetella pertussis infection in Chandigarh. Indian Journal of Medical Research. 1973 May; 61(5): 645-8. ...

https://imsear.searo.who.int/handle/123456789/21222

Filed Under: How to Parent Tips, The Breeze Tagged With: adult vaccinations, Bordetella pertussis, contagious diseases, ... Whooping Cough is a highly contagious, vaccine-preventable bacterial disease caused by Bordetella pertussis. It lasts for many ... The perception that pertussis is something we dont have to worry about obscures the fact that, despite effective vaccines and ... For many people, pertussis (commonly known as Whooping Cough) is old news-a once-feared disease long controlled by vaccination ...

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Pathogenesis and immunity in pertussis / edited by Alastair C. Wardlaw and Roger Parton. by Wardlaw, Alastair C , Parton, Roger ... The immunological basis for immunization series: module 4: pertussis - update 2009. by World Health Organization. ... pertussis - update 2009..Online access: Click here to access online Availability: Items available for loan: WHO HQ (1)Call ...

https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=su:%7BBordetella%20pertussis%7D

Dive into the research topics of A qPCR assay for Bordetella pertussis cells that enumerates both live and dead bacteria. ... A qPCR assay for Bordetella pertussis cells that enumerates both live and dead bacteria. ...

https://researchportal.bath.ac.uk/en/publications/a-qpcr-assay-for-bordetella-pertussis-cells-that-enumerates-both-/fingerprints/?sortBy=alphabetically

Pertussis FHA IgA och IgG samt Pertussis toxin IgA och IgG, utförs alltid tillsammans. ...

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Es un análisis para determinar la presencia de anticuerpos contra la Bordetella pertussis en la sangre. La B. pertussis es la ... Anticuerpos contra Bordetella pertussis (en sangre). ¿Esta prueba tiene otros nombres?. Prueba de anticuerpos contra la tos ... Si nunca lo vacunaron contra la tos ferina, el valor normal de anticuerpos contra la B. pertussis es de cero. Si tiene la ... vacuna, es probable que tenga anticuerpos IgG contra la B. pertussis, incluso si no está atravesando una infección activa de ...

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Bordetella pertussis. Macrolide. Trimethoprim- sulfamethoxazole. Anaerobe (aspiration). Beta-lactam/beta-lactamase inhibitor, ...

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Bordetella pertussis; Coqueluche; Humanos; Toxina Pertussis; Fatores de Virulência de Bordetella; Toxina Adenilato Ciclase; ... Pasteurian Contributions to the Study of Bordetella pertussis Toxins. Locht, Camille. Afiliação *Locht C; Univ. Lille, CNRS, ... Pasteurian Contributions to the Study of ,i,Bordetella pertussis,/i, Toxins. ... Bordetella pertussis / Coqueluche Tipo de estudo: Estudo prognóstico / Revisão sistemática Limite: Humanos Idioma: Inglês Ano ...

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Pertussis is a highly contagious bacterial disease that causes uncontrollable, violent coughing. The coughing can make it hard ... Pertussis (Bordetella pertussis and Bordetella parapertussis). In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, ... Pertussis, or whooping cough, is an upper respiratory infection. It is caused by the Bordetella pertussis bacteria. It is a ... Pertussis should always be considered when vomiting occurs with coughing. In infants, choking spells and long pauses in ...

https://medlineplus.gov/ency/article/001561.htm

Bordetella pertussis 1 * Bordetella petrii 1 * Bradyrhizobium sp. 1 * Brucella abortus 1 ...

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Bordetella pertussis strain lacking pertactin and pertussis toxin. (cdc.gov)
In addition, Bordetella pertussis also has the ability to inhibit the function of the host's immune system via pertussis toxin (PT). (labmanager.com)
Anti-B. pertussis Toxin IgG is is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against pertussis toxin in human serum or. (launchdiagnostics.com)
The Bordetella pertussis toxin (PT) Antibody (IgG), Im test contains 1 test with 1 biomarker. (ultalabtests.com)
Pertussis FHA IgA och IgG samt Pertussis toxin IgA och IgG, utförs alltid tillsammans. (regionvastmanland.se)
Purified native pertussis toxin from Bordetella pertussis , in lyophilised form for ease of shipping, activity tested in a CHO cluster assay. (thenativeantigencompany.com)
Bordetella pertussis toxin has been developed in response to increasing pressure on the IVD industry to supply highly specific, cost-effective antibody capture systems, which are needed for monitoring vaccination programmes. (thenativeantigencompany.com)
Our PT-TNL-50 vials are a major seller to academic labs seeking to use pertussis toxin as a research reagent, and are also sold through large worldwide distributors. (thenativeantigencompany.com)
Genomic variations are mostly studied in the circulating strains of B. pertussis to know the pathogen adaptation to the vaccine antigens such as pertussis toxin ( ptx ), pertactin ( prn ), fimbriae ( fim ) and filamentous hemagglutinin (FHA) [ 3 ]. (jgenomics.com)
Besides identifying B. pertussis as the causative agent of whooping cough , Pasteurians have made several major contributions with respect to the structure-function relationship of the Bordetella lipo- oligosaccharide , adenylyl cyclase toxin and pertussis toxin . (bvsalud.org)
Analysis of Bordetella pertussis pertactin and pertussis toxin types from Queensland, Australia, 1999-2003. (cdc.gov)
These changes include antigenic divergence with vaccine strains and increased production of pertussis toxin. (cambridge.org)
Antigenic divergence will affect both memory recall and the efficacy of antibodies, while higher levels of pertussis toxin may increase suppression of the innate and acquired immune system. (cambridge.org)
After purification, filamentous hemagglutinin (FHA) and pertussis toxin (PT) are combined to obtain a 1:1 ratio and are then treated with formaldehyde to inactivate PT. (cdc.gov)
A PCR procedure for the detection of Bordetella pertussis in nasopharyngeal aspirates (NPAs) was developed with primers derived from the pertussis toxin promoter region. (microbiologyresearch.org)

La B. pertussis es la bacteria que causa la tos ferina. (oumedicine.com)
It is caused by the Bordetella pertussis bacteria. (medlineplus.gov)
Transmission typically happens when a person with pertussis coughs or sneezes, and another person nearby breathes in the bacteria. (livescience.com)
This Gram-stained photomicrograph depicts numbers of Bordetella pertussis bacteria, which is the etiologic pathogen for pertussis, also known as whooping cough. (livescience.com)
The term "acellular" means that the vaccine uses pieces of pertussis bacteria (not the whole bacterium cell). (cdc.gov)
Hexacima is a vaccine containing active substances derived from diphtheria, tetanus, pertussis and Haemophilus influenzae type b bacteria , the hepatitis B virus, and inactivated polioviruses. (europa.eu)

Further, the impact of vaccination needs to be established since more than one strain used in the manufacturing of pertussis vaccines globally. (jgenomics.com)
We propose these adaptations of B. pertussis have decreased the period in which pertussis vaccines are effective and thus enhanced the waning of immunity. (cambridge.org)
We plead for a more integrated approach to the pertussis problem which includes the characteristics of the vaccines, the B. pertussis populations and the interaction between the two. (cambridge.org)
Whole-cell pertussis vaccines in the United States have been and continue to be prepared from suspensions of killed Bordetella pertussis whole bacterial cells. (cdc.gov)
Routine vaccination with whole-cell vaccines has been highly effective in reducing the burden of disease and deaths due to pertussis (3). (cdc.gov)
these concerns have led to attempts to develop safer pertussis vaccines that have high efficacy. (cdc.gov)
Candidate acellular pertussis vaccines, produced by multinational manufacturers, are now available due to advances in the methods of purifying and preparing these components. (cdc.gov)
Several clinical trials, which compare relative protective efficacy of primary vaccination utilizing diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccines with that of whole-cell vaccines administered to infants, are in progress or development. (cdc.gov)
Household exposure and ecologic studies among Japanese children vaccinated at greater than or equal to 2 years of age, have suggested efficacy of the BIKEN and other acellular pertussis vaccines when combined with diphtheria and tetanus toxoids as DTaP (4-7). (cdc.gov)
Protection against pertussis in the very young baby - adult vaccines, pre-partum maternal immunization or neonatal immunization? (escmid.org)
Before pertussis vaccines became widely available in the 1940s, about 200,000 children got sick with it each year in the U.S.and about 9,000 died as a result of the infection," the CDC says on its website. (go.com)
So, we get vaccines for our dogs against Bordetella . (cdc.gov)
We do get vaccines for our dogs against Bordetella . (cdc.gov)
The mutation rate of a virus is considerably higher than that of a bacterium, meaning that in this case, in our case, Bordetella pertussis does not evolve that fast except for the antigen genes that are used in the commercial vaccines. (cdc.gov)
Infant immunization programmes using pertussis vaccines have been highly successful in preventing severe pertussis in infants all over the world. (who.int)

Pertactin-negative Bordetella pertussis strains: Evidence for a possible selective advantage. (cdc.gov)
Multiple-locus variable-number tandem repeat analysis of Dutch Bordetella pertussis strains reveals rapid genetic changes with clonal expansion during the late 1990s. (cdc.gov)
Sharma NC, Anandan S, Devanga Ragupathi NK, Muthuirulandi Sethuvel DP, Vasudevan K, Kumar D, Gupta SK, Sangal L, Veeraraghavan B. Genetic Diversity of Clinical Bordetella Pertussis ST2 Strains in comparison with Vaccine Reference Strains of India. (jgenomics.com)
Current study reports the highly accurate complete genomes of two clinical B. pertussis strains from India for the first time. (jgenomics.com)
Complete genome sequencing was performed for two B. pertussis strains using Ion Torrent PGM and Oxford nanopore sequencing method. (jgenomics.com)
The two B. pertussis clinical strains exhibited diversity through genome degradation when compared to whole-cell vaccine reference strains of India. (jgenomics.com)
The genome information of Indian clinical B. pertussis strains will serve as a baseline data to decipher more information on the genome evolution, virulence factors and their role in pathogenesis for effective vaccine strategies. (jgenomics.com)
The comparative genomic analysis would provide high resolution data to study the structural variations in the circulating strains of B. pertussis against vaccine strains. (jgenomics.com)
Here we report the comparative genomic analysis of two clinical isolates of B. pertussis from India against the vaccine reference strains 6229, 25525, 134, 509, 10536 and Tohama I. (jgenomics.com)
Temporal trends in circulating Bordetella pertussis strains in Australia. (cdc.gov)
Comparisons with vaccine strains are included.Results: From 8,176 patients with pertussis clinical signs, 22.9% were confirmed: 523 in 2006, 617 in 2007, and 734 in 2008. (conicet.gov.ar)
Moreover, while vaccine strains contain prn1/7 and ptxS1 B/D alleles, local isolates have prn2 and ptxS1A.Conclusions: Pertussis is an important problem for public health in Argentina. (conicet.gov.ar)
Delay in vaccine application, and divergence between vaccine strains and local isolates could contribute to the described pertussis epidemiology. (conicet.gov.ar)

Cassiday PK, Skoff TH, Jawahir S, Tondella ML. Changes in the predominance of pulsed-field gel electrophoresis profiles of Bordetella pertussis isolates, United States, 2000-2012. (cdc.gov)
2 ). Forty-one potential VNTR loci from the B. pertussis Tohama I genome ( 3 ) were identified and screened on a panel of 18 B. pertussis isolates selected on the time and locality of isolation (Supplementary Table 1). (cdc.gov)
pertussis isolates in Japan. (cdc.gov)
Disease relevance of brk A In this study, we set up a real- time reverse transcriptase PCR assay to measure the relative amounts of brk A transcripts in 50 Bordetella isolates. (wikigenes.org)
Differential In Vitro Expression of the brk A Gene in Bordetella pertussis and Bordetella parapertussis Clinical Isolates. (wikigenes.org)
B. pertussis isolates were characterized by pulse filed gel electrophoresis (PFGE) and prn and ptx genotypes. (conicet.gov.ar)

Sources of infant pertussis infection in the United States. (cdc.gov)
In most cases, serology testing is not recommended for the diagnosis of active pertussis infection. (aruplab.com)
IMSEAR at SEARO: Bordetella pertussis infection in Chandigarh. (who.int)
Pertussis, or whooping cough, is an upper respiratory infection. (medlineplus.gov)
DTaP vaccination , one of the recommended childhood immunizations, protects children against pertussis infection. (medlineplus.gov)
Pertussis, caused by Bordetella pertussis, is a highly contagious respiratory infection, characterized by severe episodes of coughing and a prolonged convalescent period when the patient can transmit the disease [ 1 ]. (jgenomics.com)
These applications range from the development of novel tools to study protein - protein interactions over the design of novel antigen delivery tools, such as prophylactic or therapeutic vaccine candidates against cancer and viral infection , to the development of a live attenuated nasal pertussis vaccine . (bvsalud.org)
Pertussis or whooping cough has persisted and resurged in the face of vaccination and has become one of the most prevalent vaccine-preventable diseases in Western countries with estimated infection frequencies of 1-9% [ Reference Ward 1 - Reference Hallander 4 ]. (cambridge.org)
Whooping cough, also known as pertussis, is a bacterial infection of the respiratory tract that causes severe coughing. (livescience.com)
After a week or two, pertussis infection delivers its cruel surprise - uncontrollable, violent coughing spells. (cdc.gov)
It stopped them from getting influenza which in turn protected them from getting a co-infection of pertussis. (news24.com)
ABSTRACT Although pertussis is a vaccine-preventable infection, vaccine-induced immunity is not lifelong and booster doses are recommended according to national disease epidemiology. (who.int)
RÉSUMÉ Si la coqueluche est une infection évitable par la vaccination, l'immunité induite par le vaccin ne dure pas toute la vie et des doses de rappel sont recommandées en fonction de l'épidémiologie de la maladie dans le pays. (who.int)
There were some severe cases of pertussis among infants caused mainly by B. pertussis and dual Bordetella infection. (who.int)
A highly infectious, vaccine-preventable disease lasting many weeks, is caused by infection with Bordetella Pertussis. (who.int)
In cases of severe pneumonia and ARDS, can there be a bacterial co-infection, such as bordatella pertussis, that has been vaccinated in childhood but whose antibody titer has declined over the years? (ejmo.org)

Bordetella pertussis is a Gram-negative human-restricted bacterium that evolved from the broad-range mammalian pathogen, Bordetella bronchiseptica. (pasteur.fr)
Pertussis is a highly contagious disease of the respiratory tract caused by Bordetella pertussis , a bacterium that lives in the mouth, nose, and throat. (jgenomics.com)
Whooping cough is caused by the bacterium Bordetella pertussis . (livescience.com)
Pertussis is a highly contagious respiratory disease caused by the bacterium Bordetella pertussis . (news24.com)
The contagious cough, named for its "whooping" sound, is caused by the bacterium Bordetella pertussis, which is spread through coughs and sneezes. (go.com)
Bordetella pertussis is a gram- negative bacterium that is responsible for the highly contagious respiratory disease known as pertussis. (cdc.gov)

San Diego, CA - Binding Site's Immunologicals Group is pleased to announce the addition of three (3) new Bordetella pertussis (VZV) antigens to its broad offering of products for in-vitro diagnostic (IVD) manufacturing and research applications. (labmanager.com)
All of these Bordetella pertussis antigens exhibit exceptional purity levels as a result of chromatography techniques and demonstrate exceptional lot-to-lot consistencies, while displaying the highest degrees of activity and specificity. (labmanager.com)
Chan WF , Maharjan RP , Reeves PR , Sintchenko V , Gilbert GL , Lan R . Rapid and accurate typing of Bordetella pertussis targeting genes encoding acellular vaccine antigens using real time PCR and high resolution melt analysis. (cdc.gov)

CDC-recommended first-line tests for pertussis are Bordetella pertussis/parapertussis by PCR ( 0065080 ) and/or Bordetella pertussis Culture ( 0060117 ). (aruplab.com)

But pertussis vaccination rate in Texas - about 94 percent - lags behind the national average , according to the U.S. Centers for Disease Control and Prevention. (go.com)

Whooping Cough' is a highly contagious, vaccine-preventable bacterial disease caused by Bordetella pertussis. (breezymama.com)
Pertussis is a highly contagious bacterial disease that causes uncontrollable, violent coughing. (medlineplus.gov)
Whooping cough (pertussis) is a contagious illness. (ahealthyme.com)
Pertussis is highly contagious (easy to catch). (cdc.gov)
Pertussis is a highly contagious bacterial disease of the respiratory tract caused by Bordetella pertussis . (who.int)

1.05 IV or greater: Positive - IgG antibody to B. pertussis detected, which may indicate a current or recent exposure/immunization to B. pertussis . (aruplab.com)
Immunological basis for immunization : module 4: pertussis - update 2009. (who.int)
Since 2005, a single dose of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine has been recommended by the Advisory Committee on Immunization Practices (ACIP) for adolescents and adults ( 1 , 2 ). (cdc.gov)
Proportion of pertussis cases by age, immunization status, and immunization coverage rate evaluated at the Argentinean National Pertussis Reference Center are reported. (conicet.gov.ar)

3. Kuo SC, Shih SM, Chien LH, Hsiung CA. Collateral benefit from 10 patients with pertussis revealed a macrolide-re- of COVID-19 control measures on influenza activity, sistant mutation, A2047G, in the 23S rRNA. (cdc.gov)
Usually these patients with pertussis experience around the second week after the onset of the symptoms a fit of coughing, followed by a high-pitched whoop sound, and hence the name of whooping cough. (cdc.gov)

The high circulation rate of Bordetella pertussis poses a threat to infants that have not been (completely) vaccinated and for whom pertussis is a severe, life-threatening, disease. (cambridge.org)
Pregnant women are recommended to receive a dose of Tdap during each pregnancy to prevent pertussis in infants too young for routine vaccination (off-label use*) ( 3 ). (cdc.gov)
Pertussis, also known as whooping cough, is a respiratory disease that can be fatal, especially for infants. (cdc.gov)
Many infants who get pertussis are infected by older siblings, parents or caregivers who might not even know they have the disease Pertussis loves crowded locations to encourage close contact among potential victims and to make its job easier. (cdc.gov)
Pertussis is a bully, often causing serious and sometimes life-threatening complications in infants and young children, especially those who are not fully vaccinated. (cdc.gov)
In infants younger than 1 year of age who get pertussis, more than half are hospitalized. (cdc.gov)
Whooping cough, or pertussis, mainly affects infants and young children. (childrenshospital.org)
Texas has already seen two pertussis-related deaths this year - both of them in infants who were too young to be vaccinated, according to the state's department of health. (go.com)

During 2010, 27,550 cases of pertussis were reported in the U.S. - the most since 1959. (cdc.gov)
5 According to data on vaccine-preventable diseases collected through the WHO/United Nations Children's Fund (UNICEF) Joint Reporting Form, around 5000 suspected cases of pertussis were reported in syndromic surveillance by health workers in Papua New Guinea in 2010. (who.int)

General recommendations on pertussis prevention were issued August 8, 1991, in the ACIP statement on diphtheria, tetanus, and pertussis (1). (cdc.gov)
A supplementary statement on the use of diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP) was issued February 7, 1992 (2) after the licensure of ACEL-IMUNE (Registered), prepared by Lederle Laboratories. (cdc.gov)
Simultaneous vaccination against diphtheria, tetanus, and pertussis during infancy and childhood has been a recommended routine practice in the United States since the late 1940s. (cdc.gov)
Repeat doses of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine at 5- and 10-year intervals are safe and immunogenic. (cdc.gov)
Since 2005, a single booster dose of Tdap has been recommended for children and adolescents aged 11-18 years and adults aged 19-64 years ( 1 , 2 ) to increase protection against tetanus, diphtheria, and pertussis. (cdc.gov)
The vaccine ammo contains diphtheria (the D), tetanus (the T), and acellular pertussis (the aP). (cdc.gov)
This is usually part of the DTaP vaccine (which stands for diphtheria, tetanus, and pertussis). (childrenshospital.org)
The Central Province conducted a response vaccination programme providing 65% of children less than five years of age with diphtheria-pertussis-tetanus-HepB-Hib vaccine at a cost of US$ 12.62 per child. (who.int)
That same year, 70% of children less than one year of age in Papua New Guinea received three doses of diphtheria-pertussis-tetanus vaccine (DPT). (who.int)
6 In Papua New Guinea, DPT has been provided as diphtheria-pertussis-tetanus-hepatitis B-Haemophillus influenza B (pentavalent) vaccine since 2008. (who.int)

A lack of adequate evidence, until recently, to demonstrate the effectiveness of any single preparation has delayed U.S. licensure for any indication of a candidate acellular pertussis vaccine. (cdc.gov)
The acellular pertussis vaccine components are purified from Bordetella pertussis by salt precipitation, ultracentrifugation, and ultrafiltration. (cdc.gov)
Booster vaccination with an acellular pertussis vaccine should be considered in adolescents and/or adults in our region. (who.int)

However, significant changes in B. pertussis populations have been observed after the introduction of vaccinations, suggesting a role for pathogen adaptation in the persistence and resurgence of pertussis. (cambridge.org)

On the other hand, when applied to two batches of Bordetella bronchiseptica strain 4650, it highlighted the presence, in one of them, of hitherto unreported hexosamine residues substituting the lipid A phosphate groups, possibly a new camouflage opportunity to escape a host defense system. (jlr.org)
But the dog's Bordetella belongs to the species Bordetella bronchiseptica , which is not the same as the one that produces disease in humans. (cdc.gov)

If you've been reading the news the past few weeks, you may have heard about the recent outbreak of pertussis that has reached epidemic levels in Washington. (cdc.gov)
A large outbreak of pertussis was detected during March 2011 in Goilala, a remote district of the Central Province in Papua New Guinea, characterized by rugged topography with no road access from the provincial headquarters. (who.int)
On 30 March 2011, the health workers of Ononge health centre, through the Health Secretary of Catholic Health-Diocese of Berenia, informed the Central Provincial Health Office about a suspected outbreak of pertussis in several villages of the Goilala district. (who.int)

A person with pertussis will infect almost everyone in their household if those people aren't vaccinated. (cdc.gov)

Pertussis is primarily an "air attacker," flying through the air looking for its next victim, when an infected person coughs or sneezes. (cdc.gov)
Anyone can get pertussis, which is spread from person to person when an infected person coughs or sneezes. (news24.com)

It causes whooping cough or pertussis in humans, which is the most prevalent vaccine-preventable disease worldwide. (pasteur.fr)
Despite high-levels of vaccination, whooping cough, primarily caused by Bordetella pertussis (BP), has persisted and resurged. (biorxiv.org)
For many people, pertussis (commonly known as Whooping Cough) is old news-a once-feared disease long controlled by vaccination. (breezymama.com)
Pertussis or whooping cough has persisted and resurged in the face of vaccination and has become one of the most prevalent vaccine-preventable diseases in Western countries. (cambridge.org)
Whooping cough, or pertussis, gets its name from the "whoop" sound that a person (typically a child) makes when he or she gasps for air after a coughing fit. (livescience.com)
Research shows that children under the age of six months have the highest burden of respiratory diseases such as influenza and whooping cough, known as pertussis . (news24.com)
Bordetella pertussis is the agent responsible for whooping cough, a disease that is currently on the rise. (pasteur.fr)
So the term 'whooping cough' comes essentially from the sound that a person that suffers from pertussis disease makes while coughing. (cdc.gov)
It is noteworthy that the number of CD4 T lymphocytes has decreased in the laboratory findings of whooping cough, and that some medicines used in treatment (Chloroquine, erythromycin) can also be used in Bordetella species. (ejmo.org)

Guris D , Strebel PM , Bardenheier B , Brennan M , Tachdjian R , Finch E , Changing epidemiology of pertussis in the United States: increasing reported incidence among adolescents and adults, 1990-1996. (cdc.gov)
It means that pertussis is reappearing again with increasing incidence rates despite the high vaccination coverage, of course, in most of the countries. (cdc.gov)

However, genome data of B. pertussis is rare in India due to the complexity of culturing B. pertussis from clinical samples. (jgenomics.com)

0.94 IV or less: Negative - No significant level of detectable B. pertussis IgG antibody. (aruplab.com)
If Bordetella pertussis Antibody, IgG by ELISA is 1.05 IV or greater, then Bordetella pertussis IgG Immunoblot testing will be added. (aruplab.com)

Here we describe pertussis epidemiology in Argentina during 2006-2008 and discuss possible reasons for increase.Methods: CDC criteria were used for pertussis diagnosis. (conicet.gov.ar)

Severe pertussis infections in the United States, 2011-2015. (cdc.gov)
Disease relevance of brk A We have recently observed that a B. pertussis strain, putatively with a mutation of a single gene, brk A, results in a severe defect in vivo. (wikigenes.org)

test does not determine immunity to B. pertussis . (aruplab.com)
Pathogenesis and immunity in pertussis / edited by Alastair C. Wardlaw and Roger Parton. (who.int)
The increase in pertussis is mainly found in age groups in which immunity has waned and this has resulted in the perception that waning immunity is the main or exclusive cause for the resurgence of pertussis. (cambridge.org)

The introduction of the pertussis whole-cell vaccination for young children, followed by the introduction of the pertussis acellular vaccination (along with booster vaccination) for older age groups, has affected the bacterial population and epidemiology of the disease. (pasteur.fr)
All students had received a full course of pertussis whole-cell vaccination at ages 2, 4, 6 and 18 months and 4-6 years. (who.int)

Tan T , Trindade E , Skowronski D . Epidemiology of pertussis. (cdc.gov)

These studies illustrated that genome evolution in B. pertussis is mainly due to rearrangement in addition to genome reduction [ 2 ]. (jgenomics.com)

Pasteurian Contributions to the Study of Bordetella pertussis Toxins. (bvsalud.org)
As a tribute to Louis Pasteur on the occasion of the 200th anniversary of his birth , this article summarizes the main contributions of scientists from Pasteur Institutes to the current knowledge of toxins produced by Bordetella pertussis . (bvsalud.org)
The article therefore focuses on publications authored by researchers from Pasteur Institutes and is not intended as a systematic review of B. pertussis toxins. (bvsalud.org)

Several antigenic components of Bordetella pertussis have been identified. (cdc.gov)

B. pertussis is relatively monomorphic worldwide, but nevertheless, different countries are facing different epidemiological evolutions of the disease. (pasteur.fr)
Adults who have been vaccinated against pertussis may have more mild symptoms of the disease, and so they may think they have a regular cold and not go to the doctor, Jordan-Villegas said. (livescience.com)
If pertussis is spreading in an area, there is a chance that a person who has had the vaccine can still catch the disease. (ahealthyme.com)
View the Pertussis Disease Villain's rap sheet below to find out more about this public health nemesis. (cdc.gov)
Pertussis can also pull off its own complications among young children, such as pneumonia, seizures, and encephalopathy (disease of the brain). (cdc.gov)
The PCR method was more efficient than culture in detecting B. pertussis in samples collected late in the disease, in antibiotic-treated children and in patients with mild disease. (microbiologyresearch.org)
The challenge is that although babies start their pertussis vaccinations when they are six weeks old, they are only protected against the disease after their third dose of the vaccine when they are three months old. (news24.com)
This disease can be mostly prevented with the pertussis vaccine. (childrenshospital.org)
Background and aims: Pertussis is a vaccine-preventable disease caused by Bordetella pertussis. (conicet.gov.ar)
Sarah Gregory] Your paper refers to pertussis as a reemerging disease. (cdc.gov)

Isolation and characterization of catalytic and calmodulin-binding domains of Bordetella pertussis adenylate cyclase. (archives-ouvertes.fr)

Tracking Pertussis and Evaluating U.S. Control Measures through the Emerging Infections Program Network's Enhanced Pertussis Surveillance System. (cdc.gov)
Inflammation and infections as risk to prevent and control pertussis, but in many coun- factors for ischemic stroke. (cdc.gov)
Also, other bacterial infectors just love to join pertussis' party, moving into a sick person's pertussis-infected lungs to cause their own infections. (cdc.gov)
Our study proved that the women who received the influenza vaccine had less pertussis infections. (news24.com)

Using a Bordetella IgG ELISA kit, pertussis-IgG was detected in 301 (47.0%) students. (who.int)

Genomic Survey of Bordetella pertussis Diversity in the United States, 2000-2013. (cdc.gov)

Changes in genetic diversity of the Bordetella pertussis population in the United Kingdom between 1920 and 2006 reflect vaccination coverage and emergence of a single dominant clonal type. (cdc.gov)

Resurgence of pertussis in Europe. (cdc.gov)

The suspected pertussis cases, reported by health workers from the Ononge health centre area, were investigated and confirmed for the presence of Bordetella pertussis DNA using the polymerase chain reaction (PCR) method. (who.int)

Adaptation of Bordetella pertussis to vaccination: a cause for its reemergence? (cdc.gov)

Pertussis is highly infectious and can cause serious complications, especially in babies, so people should take it seriously," Cornelius said. (go.com)

Anatomy5

Organisms6

Diseases5

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes7

Information Science3

Health Care2

Role of antibodies against Bordetella pertussis virulence factors in adherence of Bordetella pertussis and Bordetella parapertussis to human bronchial epithelial cells. (1/1244)

Role of Bordetella pertussis virulence factors in adherence to epithelial cell lines derived from the human respiratory tract. (2/1244)

Characterization of human bactericidal antibodies to Bordetella pertussis. (3/1244)

Maternal immunization. (4/1244)

Temporal trends in the population structure of Bordetella pertussis during 1949-1996 in a highly vaccinated population. (5/1244)

Analysis with a combination of macrorestriction endonucleases reveals a high degree of polymorphism among Bordetella pertussis isolates in eastern France. (6/1244)

Serum IgG antibody responses to pertussis toxin and filamentous hemagglutinin in nonvaccinated and vaccinated children and adults with pertussis. (7/1244)

The conserved lysine 860 in the additional fatty-acylation site of Bordetella pertussis adenylate cyclase is crucial for toxin function independently of its acylation status. (8/1244)

Bordetella pertussis

Bordetella

Pertussis Vaccine

Bordetella Infections

Bordetella bronchiseptica

Whooping Cough

Virulence Factors, Bordetella

Pertussis Toxin

Bordetella parapertussis

Hemagglutinins

Adenylate Cyclase Toxin

Bordetella avium

Vaccines, Acellular

Antibodies, Bacterial

Adhesins, Bacterial

Adenylate Cyclase

Leukocytosis

Agglutinins

Bacterial Outer Membrane Proteins

Bacterial Proteins

Diphtheria-Tetanus-acellular Pertussis Vaccines

Diphtheria-Tetanus-Pertussis Vaccine

Nasopharynx

Antigens, Bacterial

Toxoids

Molecular Sequence Data

Genes, Bacterial

Virulence

Lymphocytosis

Gene Expression Regulation, Bacterial

DNA, Bacterial

Vaccination

Bacterial Adhesion

Siderophores

Mice, Inbred BALB C

Immunoglobulin G

Base Sequence

Immunization

Amino Acid Sequence

Agglutination Tests

Fimbriae, Bacterial

Diphtheria Toxoid

Trachea

Rhinitis, Atrophic

GTP-Binding Proteins

Bacterial Toxins

Adenosine Diphosphate Ribose

Respiratory System

Bacterial Vaccines

Hemolysin Proteins

Lung

Antitoxins

Cyclic AMP

Polymerase Chain Reaction

Enzyme-Linked Immunosorbent Assay

Immunoglobulin A

DNA Transposable Elements

Role of antibodies against Bordetella pertussis virulence factors in adherence of Bordetella pertussis and Bordetella parapertussis to human bronchial epithelial cells. (1/1244)

Role of Bordetella pertussis virulence factors in adherence to epithelial cell lines derived from the human respiratory tract. (2/1244)

Characterization of human bactericidal antibodies to Bordetella pertussis. (3/1244)

Maternal immunization. (4/1244)

Temporal trends in the population structure of Bordetella pertussis during 1949-1996 in a highly vaccinated population. (5/1244)

Analysis with a combination of macrorestriction endonucleases reveals a high degree of polymorphism among Bordetella pertussis isolates in eastern France. (6/1244)

Serum IgG antibody responses to pertussis toxin and filamentous hemagglutinin in nonvaccinated and vaccinated children and adults with pertussis. (7/1244)

The conserved lysine 860 in the additional fatty-acylation site of Bordetella pertussis adenylate cyclase is crucial for toxin function independently of its acylation status. (8/1244)

Bordetella pertussis adenylate cyclase. Penetration into host...

Permalien vers Bordetella pertussis adenylate cyclase toxin. Structural and functional independence of the catalytic and...

The Effect of Bordetella Pertussis on the Antibody Response in Mice to Type III Pneumococcal Polysaccharide | The Journal of...

Virulence of Pertactin-Negative Bordetella pertussis Isolates from Infants, France - Volume 19, Number 3-March 2013 - Emerging...

Changes in the genomic content of circulating Bordetella pertussis strains isolated from the Netherlands, Sweden, Japan and...

The mitogenic effect of the lymphocytosis promoting factor from Bordetella pertussis on human lymphocytes

Extracellular cAMP formation from host cell ATP by Bordetella Pertussis adenylate cyclase | IRIS Università degli Studi del...

Welcome to CDC stacks | Population Diversity among Bordetella pertussis Isolates, United States, 1935-2009 - 18731 | Emerging...

Rapid Increase in Pertactin-deficient Bordetella pertussis Isolates, Australia - Volume 20, Number 4-April 2014 - Emerging...

0288 Complete genome sequence of a clinical Bordetella pertussis isolate from Brazil

Surveillance of circulating bordetella pertussis strains in Europe during 1998 to 2015<...

Detection of anti-pertussis toxin IgG in oral fluids for use in diagnosis and surveillance of Bordetella pertussis infection in...

The effects of Bordetella pertussis on dendritic cell imprinting of CD by Sana Waheed

Intracellular survival of virulent Bordetella pertussis in human polymorphonuclear leukocytes<...

Complete Genome Sequence of Bordetella pertussis CS, a Chinese Pertussis Vaccine Strain | Journal of Bacteriology