Bordetella Infections: Infections with bacteria of the genus BORDETELLA.Bordetella: A genus of gram-negative, aerobic bacteria whose cells are minute coccobacilli. It consists of both parasitic and pathogenic species.Bordetella bronchiseptica: A species of BORDETELLA that is parasitic and pathogenic. It is found in the respiratory tract of domestic and wild mammalian animals and can be transmitted from animals to man. It is a common cause of bronchopneumonia in lower animals.Bordetella parapertussis: A species of BORDETELLA with similar morphology to BORDETELLA PERTUSSIS, but growth is more rapid. It is found only in the RESPIRATORY TRACT of humans.Bordetella pertussis: A species of gram-negative, aerobic bacteria that is the causative agent of WHOOPING COUGH. Its cells are minute coccobacilli that are surrounded by a slime sheath.Virulence Factors, Bordetella: A set of BACTERIAL ADHESINS and TOXINS, BIOLOGICAL produced by BORDETELLA organisms that determine the pathogenesis of BORDETELLA INFECTIONS, such as WHOOPING COUGH. They include filamentous hemagglutinin; FIMBRIAE PROTEINS; pertactin; PERTUSSIS TOXIN; ADENYLATE CYCLASE TOXIN; dermonecrotic toxin; tracheal cytotoxin; Bordetella LIPOPOLYSACCHARIDES; and tracheal colonization factor.Bordetella avium: A species of BORDETELLA isolated from the respiratory tracts of TURKEYS and other BIRDS. It causes a highly contagious bordetellosis.Pertussis Vaccine: A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)Hemagglutinins: Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.Adenylate Cyclase Toxin: One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLYL CYCLASES and hemolysin components.Pertussis Toxin: One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.Rhinitis, Atrophic: A chronic inflammation in which the NASAL MUCOSA gradually changes from a functional to a non-functional lining without mucociliary clearance. It is often accompanied by degradation of the bony TURBINATES, and the foul-smelling mucus which forms a greenish crust (ozena).Complement Fixation Tests: Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.Whooping Cough: A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.GermanyVaccines, Acellular: Vaccines that are produced by using only the antigenic part of the disease causing organism. They often require a "booster" every few years to maintain their effectiveness.Product Surveillance, Postmarketing: Surveillance of drugs, devices, appliances, etc., for efficacy or adverse effects, after they have been released for general sale.Diphtheria-Tetanus-acellular Pertussis Vaccines: Combined vaccines consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and an acellular form of PERTUSSIS VACCINE. At least five different purified antigens of B. pertussis have been used in various combinations in these vaccines.Diphtheria-Tetanus-Pertussis Vaccine: A vaccine consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and whole-cell PERTUSSIS VACCINE. The vaccine protects against diphtheria, tetanus, and whooping cough.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Vaccines: Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.Vaccination: Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.Immunization Schedule: Schedule giving optimum times usually for primary and/or secondary immunization.Vaccines, Combined: Two or more vaccines in a single dosage form.Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Retinal Vessels: The blood vessels which supply and drain the RETINA.Retinal DiseasesSelf-Help Groups: Organizations which provide an environment encouraging social interactions through group activities or individual relationships especially for the purpose of rehabilitating or supporting patients, individuals with common health problems, or the elderly. They include therapeutic social clubs.Postpericardiotomy Syndrome: A nonspecific hypersensitivity reaction caused by TRAUMA to the PERICARDIUM, often following PERICARDIOTOMY. It is characterized by PERICARDIAL EFFUSION; high titers of anti-heart antibodies; low-grade FEVER; LETHARGY; loss of APPETITE; or ABDOMINAL PAIN.Theilovirus: A species of CARDIOVIRUS which contains three strains: Theiler's murine encephalomyelitis virus, Vilyuisk human encephalomyelitis virus, and Rat encephalomyelitis virus.Cytomegalovirus Infections: Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.United StatesChickenpox: A highly contagious infectious disease caused by the varicella-zoster virus (HERPESVIRUS 3, HUMAN). It usually affects children, is spread by direct contact or respiratory route via droplet nuclei, and is characterized by the appearance on the skin and mucous membranes of successive crops of typical pruritic vesicular lesions that are easily broken and become scabbed. Chickenpox is relatively benign in children, but may be complicated by pneumonia and encephalitis in adults. (From Dorland, 27th ed)Measles: A highly contagious infectious disease caused by MORBILLIVIRUS, common among children but also seen in the nonimmune of any age, in which the virus enters the respiratory tract via droplet nuclei and multiplies in the epithelial cells, spreading throughout the MONONUCLEAR PHAGOCYTE SYSTEM.Ontario: A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster's New Geographical Dictionary, 1988, p892 & Room, Brewer's Dictionary of Names, 1992, p391)Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Gene Regulatory Networks: Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Publications: Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Disinfection: Rendering pathogens harmless through the use of heat, antiseptics, antibacterial agents, etc.Sick Building Syndrome: A group of symptoms that are two- to three-fold more common in those who work in large, energy-efficient buildings, associated with an increased frequency of headaches, lethargy, and dry skin. Clinical manifestations include hypersensitivity pneumonitis (ALVEOLITIS, EXTRINSIC ALLERGIC); allergic rhinitis (RHINITIS, ALLERGIC, PERENNIAL); ASTHMA; infections, skin eruptions, and mucous membrane irritation syndromes. Current usage tends to be less restrictive with regard to the type of building and delineation of complaints. (From Segen, Dictionary of Modern Medicine, 1992)Air Microbiology: The presence of bacteria, viruses, and fungi in the air. This term is not restricted to pathogenic organisms.Environment, Controlled: A state in which the environs of hospitals, laboratories, domestic and animal housing, work places, spacecraft, and other surroundings are under technological control with regard to air conditioning, heating, lighting, humidity, ventilation, and other ambient features. The concept includes control of atmospheric composition. (From Jane's Aerospace Dictionary, 3d ed)Building Codes: Standards or regulations for construction which are designed to ensure safety against electrical hazards, fires, etc.

Probing the function of Bordetella bronchiseptica adenylate cyclase toxin by manipulating host immunity. (1/236)

We have examined the role of adenylate cyclase-hemolysin (CyaA) by constructing an in-frame deletion in the Bordetella bronchiseptica cyaA structural gene and comparing wild-type and cyaA deletion strains in natural host infection models. Both the wild-type strain RB50 and its adenylate cyclase toxin deletion (DeltacyaA) derivative efficiently establish persistent infections in rabbits, rats, and mice following low-dose inoculation. In contrast, an inoculation protocol that seeds the lower respiratory tract revealed significant differences in bacterial numbers and in polymorphonuclear neutrophil recruitment in the lungs from days 5 to 12 postinoculation. We next explored the effects of disarming specific aspects of the immune system on the relative phenotypes of wild-type and DeltacyaA bacteria. SCID, SCID-beige, or RAG-1(-/-) mice succumbed to lethal systemic infection following high- or low-dose intranasal inoculation with the wild-type strain but not the DeltacyaA mutant. Mice rendered neutropenic by treatment with cyclophosphamide or by knockout mutation in the granulocyte colony-stimulating factor locus were highly susceptible to lethal infection by either wild-type or DeltacyaA strains. These results reveal the significant role played by neutrophils early in B. bronchiseptica infection and by acquired immunity at later time points and suggest that phagocytic cells are a primary in vivo target of the Bordetella adenylate cyclase toxin.  (+info)

Evidence of efficacy of the Lederle/Takeda acellular pertussis component diphtheria and tetanus toxoids and pertussis vaccine but not the Lederle whole-cell component diphtheria and tetanus toxoids and pertussis vaccine against Bordetella parapertussis infection. (2/236)

A subanalysis of a recent cohort efficacy trial of a pertussis vaccine was performed to determine its efficacy against cough illnesses due to Bordetella parapertussis infections. Infants received four doses of either the Lederle/Takeda acellular pertussis component diphtheria and tetanus toxoids and pertussis (DTaP) vaccine or the Lederle whole-cell component diphtheria and tetanus toxoids and pertussis (DTP) vaccine at 3, 4.5, 6, and 15-18 months of age; controls received three doses of diphtheria and tetanus toxoids (DT) vaccine only. All subjects were prospectively followed for cough illnesses of > or = 7 days' duration; cases of B. parapertussis infection were confirmed by positive culture, household contact, or serology. Seventy-six cough illnesses due to B. parapertussis were identified; 24 occurred in 929 DTaP recipients, 37 in 937 DTP recipients, and 15 in 321 DT recipients, resulting in an efficacy of 50% for DTaP vaccine (95% CI [confidence interval], 5% to 74%) and 21% for DTP vaccine (95% CI, -45% to 56%). The data in the present analysis suggest that the Lederle/Takeda DTaP vaccine but not the Lederle whole-cell component DTP vaccine has efficacy against B. parapertussis infection.  (+info)

Outcomes of Bordetella infections in vaccinated children: effects of bacterial number in the nasopharynx and patient age. (3/236)

Five outbreaks of infection (three pertussis, one parapertussis, and one mixed) in schools were studied prospectively. Nasopharyngeal swabs were obtained from a total of 697 children for culture of Bordetella organisms. Of 50 vaccinated children with culture-confirmed Bordetella infections (29 with pertussis and 21 parapertussis), 40 were symptomatic and 10 remained symptom-free. Smaller numbers of colonies were recovered from the nasopharyngeal swabs of the asymptomatic children than from those of the symptomatic children. Older children had longer durations of illness than younger ones. Our results indicate that during outbreaks children who do not develop disease may have small amounts of Bordetella organisms in their nasopharynges and/or better immune defenses against the disease.  (+info)

Bordetella bronchiseptica infection in human immunodeficiency virus-infected patients. (4/236)

Bordetella bronchiseptica is a pleomorphic gram-negative coccobacillus that commonly causes respiratory tract infections in dogs. We identified nine human immunodeficiency virus (HIV)-infected persons with culture-confirmed B. bronchiseptica infections (eight respiratory tract and one disseminated infection). The respiratory illnesses ranged in severity from mild upper respiratory tract infection to pneumonia. All nine patients had had at least one AIDS-defining condition before the B. bronchiseptica infection. Two patients had household contact with dogs before their illnesses, and one had household contact with cats. Infection due to B. bronchiseptica is uncommon in HIV-infected persons. Additional data are needed to fully define the spectrum of disease due to B. bronchiseptica infections and to evaluate the possibility that this infection may be acquired from pets. Treatment of B. bronchiseptica infection should be tailored to the patient and should be based on the results of susceptibility testing.  (+info)

Parapertussis and pertussis: differences and similarities in incidence, clinical course, and antibody responses. (5/236)

OBJECTIVES: To compare the incidence, clinical course, and serologic response to Bordetella antigens in patients with parapertussis and pertussis. DESIGN: Two studies were performed in Sweden during the 1990s, when pertussis vaccines were used only in clinical trials. Study I was a retrospective study of patients with positive Bordetella cultures obtained in clinical routine, and study II involved an active search for patients with Bordetella infections during a placebo-controlled trial of a pertussis toxoid vaccine. RESULTS: Study I includes 58, and study II 23 patients with parapertussis. In study I, the incidence of parapertussis was 0.016 cases per 100 person years in children 0 to 6 years old and 0 in older children and adults. In study II, the incidence rates of parapertussis and pertussis were 0.2 and 16.2 per 100 person years, respectively, in children followed from 3 months to 3 years of age. The median number of days with cough was 21 in parapertussis and 59 in pertussis. The proportions of children with whooping and vomiting were lower in parapertussis than in pertussis. Geometric mean serum filamentous hemagglutinin IgG increased from 6 to 63, and pertactin IgG from 4 to 12 units/mL in parapertussis patients, which was similar to increases in children with pertussis. CONCLUSIONS: Disease caused by Bordetella parapertussis is diagnosed less commonly and is milder and of shorter duration than disease caused by Bordetella pertussis. Parapertussis induced serum IgG against filamentous hemagglutinin and pertactin of similar magnitude as does pertussis, and did not induce serum IgG against pertussis toxin.  (+info)

Pregenomic comparative analysis between bordetella bronchiseptica RB50 and Bordetella pertussis tohama I in murine models of respiratory tract infection. (6/236)

We describe here a side-by-side comparison of murine respiratory infection by Bordetella pertussis and Bordetella bronchiseptica strains whose genomes are currently being sequenced (Tohama I and RB50, respectively). B. pertussis and B. bronchiseptica are most appropriately classified as subspecies. Their high degree of genotypic and phenotypic relatedness facilitates comparative studies of pathogenesis. RB50 and Tohama I differ in their abilities to grow in the nose, trachea, and lungs of BALB/c mice and to induce apoptosis, lung pathology, and an antibody response. To focus on the interactions between the bacteria and particular aspects of the host immune response, we used mice with specific immune defects. Mice lacking B cells and T cells were highly susceptible to B. bronchiseptica and were killed by intranasal inoculation with doses as low as 500 CFU. These mice were not killed by B. pertussis, even when doses as high as 10(5) CFU were delivered to the lungs. B. bronchiseptica, which was highly resistant to naive serum in vitro, caused bacteremia in these immunodeficient mice, while B. pertussis, which was highly sensitive to naive serum, did not cause bacteremia. B. bronchiseptica was, however, killed by immune serum in vitro, and adoptive transfer of anti-Bordetella antibodies protected SCID-beige mice from B. bronchiseptica lethal infection. Neutropenic mice were similarly killed by B. bronchiseptica but not B. pertussis infection, suggesting neutrophils are critical to the early inflammatory response to the former but not the latter. B. bronchiseptica was dramatically more active than B. pertussis in mediating the lysis of J774 cells in vitro and in inducing apoptosis of inflammatory cells in mouse lungs. This side-by-side comparison describes phenotypic differences that may be correlated with genetic differences in the comparative analysis of the genomes of these two highly related organisms.  (+info)

Polymorphism in the pertussis toxin promoter region affecting the DNA-based diagnosis of Bordetella infection. (7/236)

The pertussis toxin (PT) promoter region is a frequently used target for DNA-based diagnosis of pertussis and parapertussis infections. The reported polymorphism in this region has also allowed discrimination of species in mixtures with several Bordetella species by their specific PCR amplicon restriction patterns. In the present study, we investigated the degree of polymorphism in order to confirm the reliability of the assay. Five different sequence types of the amplified 239- or 249-bp region were found among the 33 Bordetella pertussis, B. parapertussis, and B. bronchiseptica American Type Culture Collection reference strains and patient isolates analyzed. According to the sequences that were obtained and according to the PT promoter sequences already available in the databases, restriction enzyme analysis with TaqI, BglI, and HaeII, which gave four different patterns, can be performed to reliably identify B. pertussis, B. parapertussis, and B. bronchiseptica.  (+info)

Biological activities of lipopolysaccharides extracted from porcine vaccine strains. (8/236)

Lipopolysaccharides (LPSs) were purified from Actinobacillus pleuropneumoniae serotype 2, Bordetella bronchiseptica and Haemophilus parasuis serotype 5, which were used for vaccine production in Japan, by the phenol-water procedure. In SDS-PAGE analysis, A. pleuropneumoniae LPS, as well as Escherichia coli LPS, demonstrated a typical ladder profile of a smooth-type LPS. On the other hand, B. bronchiseptica and H. parasuis LPSs lacked the ladder profiles. It was found that the biological activity of these LPSs was comparable to those of E. coli LPS in terms of activation of the clotting enzyme of Limulus amoebocyte lysate, mitogenic activity of mouse spleen cells, stimulation of TNF-alpha and nitric oxide production, but IL-6 production could hardly be observed in any LPS.  (+info)

*Bordetella parapertussis

"The O Antigen Enables Bordetella parapertussis To Avoid Bordetella pertussis-Induced Immunity". Infection and Immunity. 75 (10 ... Bordetella parapertussis is a small Gram-negative bacterium of the genus Bordetella that is adapted to colonise the mammalian ... "Predisposition of specific pathogen-free lambs to Pasteurella haemolytica pneumonia by Bordetella parapertussis infection". J ... "Clinical characteristics of illness caused by Bordetella parapertussis compared with illness caused by Bordetella pertussis". ...

*List of MeSH codes (C01)

... bordetella infections MeSH C01.252.400.143.740 --- whooping cough MeSH C01.252.400.155 --- borrelia infections MeSH C01.252. ... bacteroides infections MeSH C01.252.400.126 --- bartonellaceae infections MeSH C01.252.400.126.100 --- bartonella infections ... acinetobacter infections MeSH C01.252.400.610 --- mycoplasmatales infections MeSH C01.252.400.610.610 --- mycoplasma infections ... proteus infections MeSH C01.252.400.310.821 --- salmonella infections MeSH C01.252.400.310.821.438 --- paratyphoid fever MeSH ...

*Bordetella holmesii

It is often seen in conjunction with Bordetella pertussis infections (whooping cough), although not always. Weyant, Robbin S.; ... Bordetella holmesii is a Gram-negative, rod-shaped bacterium of the genus Bordetella. It was named in recognition of Barry ... August 2006). "Bordetella holmesii DNA is not detected in nasopharyngeal swabs from Finnish and Dutch patients with suspected ... 1995). "Bordetella holmesii sp. nov., a new Gram-negative species associated with septicemia". Journal of Clinical Microbiology ...

*Tracheal cytotoxin

1991). "Effects of Bordetella pertussis infection on human respiratory epithelium in vivo and in vitro". Infection and Immunity ... 1991-01-01). "Effects of Bordetella pertussis infection on human respiratory epithelium in vivo and in vitro". Infection and ... 2003). "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella ... and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies". Clinical ...

*Kennel cough

... respiratory infections involving Bordetella bronchiseptica can be transmissible for several weeks longer. While there was early ... "Detection of Respiratory Viruses and Bordetella Bronchiseptica in Dogs with Acute Respiratory Tract Infections". The Veterinary ... "Detection of respiratory viruses and Bordetella bronchiseptica in dogs with acute respiratory tract infections". Veterinary ... mixed or secondary infections can progress to lower respiratory infections such as pneumonia. The incubation period is 5-7 days ...

*Pertussis vaccine

... protective efficacy and tolerability in the prevention of Bordetella pertussis infection". Drugs. 52 (2): 254-275. doi:10.2165/ ... It included whole-cell killed Bordetella pertussis bacteria. Until the beginning of the 1990s it was used as a part of the DTwP ... The recent resurgence in pertussis infections is put down to a combination of waning immunity and new mutations in the pathogen ... Cherry, J. D. (2009). "How Can We Eradicate Pertussis". Hot Topics in Infection and Immunity in Children V. Advances in ...

*Bordetella bronchiseptica

J Clin Microbiol 31(7): 1838-44 "Prevention and control of Bordetella bronchiseptica infection in cats". Intervet/Schering- ... Bordetella bronchiseptica is a small, Gram-negative, rod-shaped bacterium of the genus Bordetella. It can cause infectious ... Genetic sequences of the Bordetella bronchiseptica complex (Sanger Institute) Type strain of Bordetella bronchiseptica at ... Hewlett, EL (1995). "Bordetella species." In: Principles and Practice of Infectious Diseases (Mandel, GL, Bennett, JE, Dolin, R ...

*CyaA

"Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the ... "The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18)". J. ... "Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin". EMBO J. 24 (18): 3190-201 ...

*Adenylyl cyclase

... cyclases are toxins secreted by pathogenic bacteria such as Bacillus anthracis and Bordetella pertussis during infection. These ...

*Bordetella

... and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies". Clin ... Bordetella is a genus of small (0.2 - 0.7 µm), Gram-negative coccobacilli of the phylum Proteobacteria. Bordetella species, ... Unlike most other Bordetella toxins, tracheal cytotoxin is expressed constitutively, being a normal product of the breakdown of ... Other members of the genus cause similar diseases in other mammals, and in birds (B. hinzii, B. avium). The Bordetella genus is ...

*Pertussis toxin

Early Chemokine Production To Delay Neutrophil Recruitment in Response to Bordetella pertussis Respiratory Tract Infection in ... Bordetella parapertussis shows the most similarity to B. pertussis and was therefore used for research determining the role of ... PT is involved in the colonization of the respiratory tract and the establishment of infection. Research suggests PT may have a ... One difference between the different species of Bordetella is that B. pertussis produces PT and the other species do not. ...

*Macrolide

Bordetella pertussis, Haemophilus influenzae), and some respiratory tract and soft-tissue infections. The antimicrobial ... This is evident, as the treatment dosage is much too low to fight infection, and in DPB cases with the occurrence of the ... Azithromycin has been used to treat strep throat (Group A streptococcal (GAS) infection caused by Streptococcus pyogenes) in ... Antibiotic macrolides are used to treat infections caused by Gram-positive bacteria (e.g., Streptococcus pneumoniae) and ...

*Hyperinsulinemic hypoglycemia

Drug induced hyperinsulinism Sulfonylurea Aspirin Pentamidine Quinine Disopyramide Bordetella pertussis vaccine or infection D- ...

*Exotoxin

DPT vaccine protects against pertussis, tetanus and diphtheria infections, caused by the exotoxin-producing Bordetella ... However, induction of cell lysis may not be the primary function of the toxins during infection. At low concentrations of toxin ... These "toxins" allow the further spread of bacteria and, as a consequence, deeper tissue infections. Examples are hyaluronidase ... forming immunological memory as protection against subsequent infections. The DPT vaccination may cause adverse side effects, ...

*Alpha-D-phosphohexomutase superfamily

"Role of phosphoglucomutase of Bordetella bronchiseptica in lipopolysaccharide biosynthesis and virulence". Infection and ... "Avirulence of a Pseudomonas aeruginosa algC mutant in a burned mouse model of infection". Infection and Immunity. 63: 4166-69. ... Pei, J.; Ficht, T.A. (2004). "Brucella abortus rough mutants are cytopathic for macrophages in culture". Infection and Immunity ... Infection and Immunity. 67: 976-80. Felek, S.; Muszynski, A.; Carlson, R.W.; Tsang, T.M.; Hinnebusch, B.J.; Krukonis, E.S. ( ...

*List of feline diseases

... an upper respiratory tract infection, caused by: Bordetella bronchiseptica Chlamydophila felis Feline calicivirus Feline viral ... Feline disease are those infections or diseases that infect cats. Some of these cause symptoms, sickness or the death of the ... syndrome Flea allergy dermatitis Florida keratopathy Haemophilus felis Head pressing Heart valve dysplasia Hookworm infection ...

*Bronchiectasis

Infective causes associated with bronchiectasis include infections caused by the Staphylococcus, Klebsiella, or Bordetella ... Aggressively treating bronchial infections with antibiotics to prevent the destructive cycle of infection, damage to bronchial ... People with bronchiectasis may have bad breath indicative of active infection. Frequent bronchial infections and breathlessness ... This is due to the occurrence of chronic infections of the sinuses and bronchiole tree. Other less-common congenital causes ...

*Bordetella trematum

It has been isolated from human ear infection and limb wounds. Below is a list of known B. trematum strains, alternative strain ... Bordetella endotoxins are unique to the genus, species, and strain. B. trematum is the only Bordetella species with a semirough ... It is unique in being oxidase negative, since all other species of Bordetella are oxidase positive. Bordetella trematum may be ... Bordetella species typically infect the respiratory tracts of humans, but B. trematum has never been isolated from a human or ...

*Upper respiratory tract infection

... and Bordetella pertussis may prevent them from infecting the URT or reduce the severity of the infection.[citation needed] The ... Most infections are viral in nature and in other instances the cause is bacterial. Upper respiratory tract infections can also ... Upper respiratory tract infections (URI or URTI) are illnesses caused by an acute infection which involves the upper ... In 2013 18.8 billion cases of upper respiratory infections were reported. As of 2014, upper respiratory infections caused about ...

*Non-fermenter

... has great relevance in the diagnosis of bacterial infections. Acinetobacter Bordetella Burkholderia Legionella Moraxella ...

*Lower respiratory tract infection

... and bordetella pertussis. Lower respiratory infectious disease is the fifth-leading cause of death and the combined leading ... Typical Bacterial Infections: Haemophilus influenzae Staphylococcus aureus Klebsiella pneumonia Atypical Bacterial Infections: ... Lower respiratory tract infection (LRTI), while often used as a synonym for pneumonia, can also be applied to other types of ... Lower respiratory tract infections place a considerable strain on the health budget and are generally more serious than upper ...

*Antigenic escape

Another bacteria, Bordetella pertussis, is able to escape the immune response by inhibiting neutrophils and macrophages from ... The immune system becomes unable to distinguish the infection from self-cells. Antigenic escape is not only crucial for ... The Mechanism Underlying Homologous Recombination in Bacteria, Which Can Infect Human Cells". Microbes and Infection. Cnops, ... invading the infection site early on. One cause of antigenic escape is that a pathogen's epitopes (the binding sites for immune ...

*Subclinical infection

Bordetella pertussis (Pertussis or whooping cough) Chlamydia pneumoniae Chlamydia trachomatis (Chlamydia) Clostridium difficile ... Such infections occur both in humans and nonhuman animals. An example of an asymptomatic infection is a mild common cold that ... Subclinical infections are important since they allow infections to spread from a reserve of carriers. They also can cause ... A subclinical infection (sometimes called a preinfection) is an infection that, being subclinical, is nearly or completely ...

*Caspian seal

These include Bordetella bronchiseptica, Streptococcus phocae, Salmonella dublin, and S. choleraesuis. Corynebacterium caspium ... Another study in 2000 using 18 Caspian seal corpses found several concurrent bacterial infections that could have contributed ...

*Teresa Lagergård

Her main field of research include investigation of bacterial virulence factors, mechanisms of infection, infections immunology ... Bordetella pertussis 1. She was a full professor of biomedicine at Mucosal Immunology and Vaccine Center in Gothenburg. ... infection, immunology and vaccine Lagergård is also an author of two books about her polish family: Postcards from grandfather ...

*Pattern recognition receptor

"Infection Mobilizes Hematopoietic Stem Cells through Cooperative NOD-like Receptor and Toll-like Receptor Signaling". Cell Host ... "Mannose receptor and macrophage galactose-type lectin are involved in Bordetella pertussis mast cell interaction". Journal of ... Since all types of PRRs play a role in the identification and eradication of the infection, their specific agonists mount a ... In a healthy individual Helicobacter pylori infection is targeted by the combination of PRRs, namely TLRs, NLRs, RLRs and CLR ...
Bordetella are small Gram-negative coccobacilli, of which Bordetella pertussis is the most important human pathogen. It is the cause of whooping cough, which is one of the 10 leading causes of childhood death. Transmission of this highly infectious organism is primarily by aerosolized droplets.Clinical features-presentation varies with age, immunization and previous infection: (1) infants-apnoea, cyanosis, and paroxysmal cough; (2) nonimmunized children-cough, increasing in severity with distressing, repeated, forceful expirations followed by a gasping inhalation (the whoop); (3) children immunized in infancy-whooping, vomiting, sputum production; (4) adults-cough, post-tussive vomiting. Atypical mild illness is common. Complications include pneumonia, pulmonary hypertension, seizures and encephalopathy. Most deaths occur in those less than 2 months old....
We describe the epidemiology of a pertussis outbreak in Japan in 2010-2011 and Bordetella holmesii transmission. Six patients were infected; 4 patients were students and a teacher at the same junior high school. Epidemiologic links were found between 5 patients. B. holmesii may have been transmitted from person to person.
Both virus and bacterial causes of kennel cough are spread through the air by infected dogs sneezing and coughing. It can also spread through contact with contaminated surfaces and through direct contact. It is highly contagious, even days or weeks after symptoms disappear. Symptoms begin usually two to three days after exposure,[2] and can progress to pneumonia. Various studies have shown that kennel cough is a zoonotic disease, meaning it can transfer from animal to human and vice versa. These studies indicate that Bordetella bronchiseptica infections in humans are uncommon and generally occur in immunocompromised individuals ...
We report 2 cases of pulmonary Bordetella hinzii infection in immunodeficient patients. One of these rare cases demonstrated the potential transmission of the bacteria from an avian reservoir through occupational exposure and its persistence in humans. We establish bacteriologic management of these infections and suggest therapeutic options if needed ...
Bordetella parapertussis ATCC ® 15311D-5™ Designation: Genomic DNA from Bordetella parapertussis Strain 522 TypeStrain=True Application:
Bordetella parapertussis: | | | | |Bordetella parapertussis| | | ... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled.
Coloured scanning electron micrograph (SEM) of Bordetella bronchiseptica, Gram-negative, aerobic, motile, coccobacillus prokaryote (bacterium). Bordetella bronchiseptica typically infects the respiratory tracts of smaller mammals (cats, dogs, rabbits). It causes infectious bronchitis, but rarely infects humans. It does not express pertussis toxin, which is one of the characteristic virulence factors of B. pertussis. It is related to Bordetella pertussis, the obligate human pathogen, that causes pertussis or whooping cough. B. bronchiseptica does not express pertussis toxin, which is one of the characteristic virulence factors of B. pertussis. Humans are not natural carriers of B. bronchiseptica. Magnification: x4,400 when shortest axis printed at 25 millimetres. - Stock Image C032/2756
Bordetella bronchiseptica ATCC ® BAA-588D-5™ Designation: Genomic DNA from Bordetella bronchiseptica strain RB50 TypeStrain=False Application:
DEMONSTRATION OF ONE YEAR DURATION-OF-IMMUNITY FOR A FELINE BORDETELLA BRONCHISEPTICA VACCINE. J.R. Williams, R. Laris. OBJECTIVE: The objective of this study was to determine the ability of a modified live intranasal Bordetella bronchiseptica vaccine (Nobivac-Bb) to prevent disease in cats for a period of one year following vaccination. EXPERIMENTAL DESIGN: Forty-eight cats were vaccinated according to manufacturers instructions. Twenty-four vaccinated cats and 12 controls were challenged with a virulent strain of B. bronchiseptica six-months after vaccination, and two additional groups of vaccinates and controls were challenged one year after vaccination. Clinical signs were recorded daily for two weeks after challenge, and clinical scores were calculated for each group. The Mann-Whitney U test was used to determine if clinical scores in the vaccinated groups were significantly different from scores in the control groups. RESULTS: The mean clinical score for vaccinated cats at six-months ...
Looking for Bordetella avium? Find out information about Bordetella avium. A nonsporulating, gram-negative coccobacillus that causes respiratory infections in birds Explanation of Bordetella avium
ICD-10 A37.11 is whooping cough due to bordetella parapertussis with pneumonia (A3711). This code is grouped under diagnosis codes for certain infectious and parasitic diseases.
A37.11 ICD 10 CM Code for Whooping cough due to Bordetella parapertussis with pneumonia, Convert ICD 10 CM code A37.11 to ICD 9 CM code.
1ZBO: X-Ray Crystal Structure of Protein BPP1347 from Bordetella parapertussis. Northeast Structural Genomics Consortium Target BoR27.
Nobivac Feline-Bb is for the intranasal vaccination of healthy kittens and cats for prevention of disease caused by Bordetella bronchiseptica. B. bronchiseptica acts as a primary or secondary pathogen in feline respiratory disease.
Bordetella is a genus of small (0.2 - 0.7 µm), Gram-negative coccobacilli of the phylum Proteobacteria. Bordetella species, with the exception of B. petrii, are obligate aerobes, as well as highly fastidious, or difficult to culture. All species can infect humans. The first three species to be described (B. pertussis, B. parapertussis, B. bronchiseptica,); are sometimes referred to as the classical species. One of these (B. bronchiseptica) is also motile. B. pertussis and occasionally B. parapertussis cause pertussis or whooping cough in humans, and some B. parapertussis strains can colonise sheep. B. bronchiseptica rarely infects healthy humans, though disease in immunocompromised patients has been reported. B. bronchiseptica causes several diseases in other mammals, including kennel cough and atrophic rhinitis in dogs and pigs, respectively. Other members of the genus cause similar diseases in other mammals, and in birds (B. hinzii, B. avium). The Bordetella genus is named after Jules ...
|EM>Bordetella pertussis|/EM>, |EM>Bordetella parapertussis|/EM> and |EM>Bordetella bronchiseptica|/EM> are closely related Gram-negative Beta-proteobacteria that colonizes the respiratory tracts of mammals. |EM>B. parapertussis|/EM> causes whooping cough in a wide range of animals. D-Alanine is a necessary precursor in the biosynthesis of cell [...]
Humoral immunity is important for protection against viral infection and neutralization of extracellular virus, but clearance of virus from infected tissues is thought to be mediated solely by cellular immunity. However, in a SCID mouse model of persistent alphavirus encephalomyelitis, adoptive transfer of hyperimmune serum resulted in clearance of infectious virus and viral RNA from the nervous system, whereas adoptive transfer of sensitized T lymphocytes had no effect on viral replication. Three monoclonal antibodies to two different epitopes on the E2 envelope glycoprotein mediated viral clearance. Treatment of alphavirus-infected primary cultured rat neurons with these monoclonal antibodies to E2 resulted in decreased viral protein synthesis, followed by gradual termination of mature infectious virion production. Thus, antibody can mediate clearance of alphavirus infection from neurons by restricting viral gene expression. ...
A Gram negative species of bacteria, Campylobacter jejuni, is the leading cause of food poisoning worldwide. Humans often contract food poisoning after ingesting contaminated poultry. Detecting the presence of C. jejuni in poultry is difficult because it is part of the natural flora and does not cause symptomatic infection. In a related manner, Bordetella avium is a Gram negative species of bacteria that causes bordetellosis in poultry. This disease is similar to whooping cough caused by the related pathogen of humans, B. pertussis. Though the mortality rate for bordetellosis is low, it weakens the birds immune systems, often leading to secondary infections. The aim of this project was to construct a vaccine platform capable of immunizing poultry against both pathogens-B. avium and C. jejuni-thus reducing disease in birds and humans. A heterologous construct can be made utilizing the B. avium autotransporter Baa1 that plays a role in host cell attachment. Autotransporters are comprised of three genetic
Free, official coding info for 2018 ICD-10-CM A37.11 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
2KAT: Solution structure of protein BPP2914 from Bordetella parapertussis. Northeast Structural Genomics Consortium target BpR206
ID A0A0H4W4T7_9BORD Unreviewed; 231 AA. AC A0A0H4W4T7; DT 14-OCT-2015, integrated into UniProtKB/TrEMBL. DT 14-OCT-2015, sequence version 1. DT 22-NOV-2017, entry version 16. DE SubName: Full=DnaA regulatory inactivator Hda {ECO:0000313,EMBL:AKQ57115.1}; GN Name=hda {ECO:0000313,EMBL:AKQ57115.1}; GN ORFNames=ACR54_03827 {ECO:0000313,EMBL:AKQ57115.1}; OS Bordetella hinzii. OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Alcaligenaceae; Bordetella. OX NCBI_TaxID=103855 {ECO:0000313,EMBL:AKQ57115.1, ECO:0000313,Proteomes:UP000036382}; RN [1] {ECO:0000313,Proteomes:UP000036382} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=F582 {ECO:0000313,Proteomes:UP000036382}; RA Weigand M.R., Changayil S., Kulasekarapandian Y., Batra D., RA Williams M.M., Tondella M.L.; RT "Complete Genome Sequences of Two Bordetella hinzii Isolated from RT Humans."; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the DnaA family. CC ...
Eight collie-cross pups, eight weeks old, were inoculated intramuscularly with an aluminum hydroxide adjuvanted preparation of killed Bordetella bronchiseptica; the inoculation was repeated after two weeks. Two weeks after the second inoculation, the vaccinated dogs and a control group of four unvaccinated animals were placed in contact with a group of five pups of similar age which had been experimentally infected with a pathogenic strain of B bronchiseptica by an aerosol method. All four unvaccinated control dogs as well as all five experimentally infected dogs developed a respiratory disease characterised by persistent coughing. Six of the vaccinated dogs remained free from clinical respiratory disease while disease was less severe and of shorter duration in the remaining two than in controls. Only slight changes were found in the lungs of vaccinated animals at necropsy while in the controls there was a severe tracheobronchitis. There was a marked reduction in the numbers of B bronchiseptica ...
Domain architecture and assignment details (superfamily, family, region, evalue) for gi|187478965|ref|YP_786989.1| from Bordetella avium 197N. Plus protein sequence and external database links.
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Directly proving aP vaccination puts treated people at risk of acquiring B. parapertussis is very difficult, but we hope our study highlights the need for more thorough B. parapertussis epidemiological data and encourages further work in this neglected area. If our experiments are capturing the phenomenology of what is happening under aP vaccination in humans, it may be important to consider the introduction of vaccines that better protect against both bordetellae; for example, live attenuated B. pertussis nasal vaccines (Mielcarek et al. 2006), wP vaccines containing both B. pertussis and B. parapertussis (Burianova-Vysoka et al. 1970), or supplementation of aP vaccines with B. parapertussis protective antigens (Zhang et al. 2009a). An enhanced understanding of the evolutionary consequences of widespread aP vaccination is needed in order to optimize the next generation of vaccination strategies and fully reap the benefits of this powerful medical intervention ...
Banked acute-phase and convalescent-phase serum samples from a previous study of respiratory illness in university students were examined for significant (≥2-fold) increases in ELISA titers of IgA and IgG antibody to Bordetella pertussis filamentous hemagglutinin, pertactin, and fimbriae-2 and ≥4-fold titer increases to agglutinogens by agglutination. ELISA titers of antibody to pertussis toxin could not be determined because of technical problems. Chlamydia pneumoniae infections were diagnosed by culture or by a ≥4-fold increase in immunofluorescence assay titer or a single high titer (≥512). Mycoplasma pneumoniae, influenza A and B, adenovirus, and respiratory syncytial virus infections were diagnosed by ≥4-fold increases in complement fixation titer or a single high titer (≥64). There were 319 subjects with cough of ≥5 days duration, and of these, 47 (15%) had significant increases in antibody to B. pertussis antigens; 26 (8%) had significant increases to fimbriae-2 or ...
Bordetella pertussis is an aerobic gram-negative bacterial pathogen that causes the human respiratory disease whooping cough. Despite widespread vaccination, whooping cough is reemerging due to decreased vaccine efficacy. One of the hallmarks of infection is lymphocytosis, which is induced by the pertussis toxin. Lymphocytes such as CD4+ T cells navigate to infected tissues through surface-trafficking molecules, which are imprinted during their interaction with tissue-associated dendritic cells. We hypothesized that the pertussis toxin affects the imprinting process resulting in altered expression of trafficking molecules on CD4+ T cells. We tested this hypothesis using a mouse model of infection. Imprinting levels on CD4+ T cells were compared to Bordetella parapertussis, a related strain that lacks pertussis toxin. Our results indicated that 5 days post-infection, the percentage of lung dendritic cells increased and adopted a mature phenotype (displaying an increased capability to migrate and present
BACKGROUND: Each year, Bordetella pertussis infection causes an estimated 294,000 deaths worldwide, primarily among young, nonvaccinated children. Approximately 90% of all deaths due to pertussis in the Unites States occur in young infants. These children often develop intractable pulmonary hypertension; however, the pathophysiologic mechanism responsible for this complication has not been well characterized, and there have been no detailed descriptions of the pathology of this disease since the 1940s.. METHODS: Respiratory tissue samples obtained at autopsy from 15 infants aged ,or=4 months who had polymerase chain reaction- or culture-confirmed B. pertussis pneumonia were evaluated by multiple histochemical stains, immunohistochemical evaluation, and electron microscopic examination.. RESULTS: The pulmonary histopathologic examination of the samples revealed a descending infection dominated by necrotizing bronchiolitis, intra-alveolar hemorrhage, and fibrinous edema. All samples had marked ...
Dr. Burns conducts undergraduate research in the area of microbiology. Students in his lab has performed projects studying interaction of Bordetella bronchiseptica with animal cells, prevalence of Bordetella species in the wild animal population, host specificity of Bordetella bronchiseptica, matrix metalloprotease activation by Group A Streptococcus, coliforms in the Olentangy River Wetlands Research Park, and carriage of Streptococcus pyogenes among Shawnee State University students. Undergraduate students have presented their research at the American Society for Microbiology general meeting, the Ohio Academy of Sciences Annual Meeting, the Beta Beta Beta Biological Honor Society District Convention, and the Celebration of Scholarship Undergraduate Conference, supported by funds from the Department of Natural Sciences, the CAS Deans Office, and the Board of Trustees Award. ...
BLOT kit for the detection of specific IgG antibodies to the recombinant antigens of Bordetella pertussis and Bordetella parapertussis in human serum and plasma, for automated processing using the BlueDiver Instrument.
Replied on 04/19/2011 If she hasnt been vaccinated within the past 6 months she may not be protected as immunity wanes quickly with this particular vaccine. Even if she has been vaccinated recently Bordetella Bronchiseptica is a bacterium that is only part of the complex of pathogens that can cause "Kennel Cough" . Other components can include Adenovirus, Parainfluenza virus , Mycoplasma and occasionally Herpes virus. The most common cause of Kennel Cough is a combination of Parainfluenza virus and Bordetella Bronchiseptica . We vaccinate against the most common strains of Bordetella and the Parainfluenza virus but there are many variants of Bordetella and we cant vaccinate against them all. The good news is that because she was vaccinated some immunity memory is present and she probably wont get as sick as she would have without the vaccine. Keep her as quiet as possible as exercise worsens the cough. Watch her for lethargy, lack of appetite or a cough that interferes with her sleeping. If ...
The Global and Chinese Bordetella Pertussis Industry, 2011-2021 Market Research Report is a professional and in-depth study on the current state of the global Bordetella Pertussis industry with a focus on the Chinese market. The report provides key statistics on the market status of the Bordetella Pertussis manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.. Complete report of 150 pages published in Jan 2016 is available at http://www.market-research-reports.com/434778-bordetella-pertussis-industry.. Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. Then, the report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 2011-2016 market shares for each company. Through the statistical analysis, the report depicts the ...
Bordetella pertussis (whooping cough) - "no known animal or environmental reservoir" (Mattoo and Cherry 2005 - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082800/ ). Bordetella bronchiseptica, B. parapertussis, and B. holmesii are "associated with respiratory infections in humans and other mammals" - B. bronchiseptica is "a major cause of kennel cough in dogs" (Mattoo and Cherry 2005 - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082800/ ). Polio can infect primates: http://jid.oxfordjournals.org/content/175/Supplement_1/S286.full.pdf. Measles: "no animal or environmental reservoir is known to exist" however "Many primate species are susceptible to measles virus infection" http://jid.oxfordjournals.org/content/204/suppl_1/S47.full.pdf+html. Cholera: aquatic plants, animals, and sediments (zzoplankton largest known) http://onlinelibrary.wiley.com/doi/10.1111/j.1758-2229.2009.00128.x/abstract. "Humans are the only natural reservoir for N. ...
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Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
This vaccine offers effective, safe and effective atrophic rhinitis prevention in baby pigs. Contains avirulent live cultures of avirulent Bordetella bronchiseptica which colonize and block the adherence of disease-causing strains ...
Looking for Bordetella? Find out information about Bordetella. A genus of gram-negative bacteria which are coccobacilli and obligate aerobes, and fail to ferment carbohydrates. These bacteria are respiratory pathogens.... Explanation of Bordetella
ID Q7WA84_BORPA Unreviewed; 113 AA. AC Q7WA84; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 08-MAY-2019, entry version 75. DE RecName: Full=Flagellar protein {ECO:0000256,RuleBase:RU362064}; GN Name=fliO {ECO:0000313,EMBL:CAE36803.1}; GN OrderedLocusNames=BPP1501 {ECO:0000313,EMBL:CAE36803.1}; OS Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253). OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Alcaligenaceae; Bordetella. OX NCBI_TaxID=257311 {ECO:0000313,Proteomes:UP000001421}; RN [1] {ECO:0000313,Proteomes:UP000001421} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=12822 / ATCC BAA-587 / NCTC 13253 RC {ECO:0000313,Proteomes:UP000001421}; RX PubMed=12910271; DOI=10.1038/ng1227; RA Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N., RA Harris D.E., Holden M.T., Churcher C.M., Bentley S.D., Mungall K.L., RA Cerdeno-Tarraga A.M., Temple L., James K., Harris B., Quail M.A., RA Achtman M., Atkin ...
ID Q7WA69_BORPA Unreviewed; 120 AA. AC Q7WA69; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 08-MAY-2019, entry version 72. DE SubName: Full=Putative flagellar protein {ECO:0000313,EMBL:CAE36820.1}; GN OrderedLocusNames=BPP1518 {ECO:0000313,EMBL:CAE36820.1}; OS Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253). OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Alcaligenaceae; Bordetella. OX NCBI_TaxID=257311 {ECO:0000313,Proteomes:UP000001421}; RN [1] {ECO:0000313,Proteomes:UP000001421} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=12822 / ATCC BAA-587 / NCTC 13253 RC {ECO:0000313,Proteomes:UP000001421}; RX PubMed=12910271; DOI=10.1038/ng1227; RA Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N., RA Harris D.E., Holden M.T., Churcher C.M., Bentley S.D., Mungall K.L., RA Cerdeno-Tarraga A.M., Temple L., James K., Harris B., Quail M.A., RA Achtman M., Atkin R., Baker S., Basham D., Bason N., ...
Bordetella Vaccines - Bordetella vaccines will ensure your pet doesnt come down with kennel cough. Learn more about bordetella vaccines and treatments.
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
False colour transmission electron micrograph (TEM) of a thin section of the whooping cough bacteria, Bordetella pertussis. The whooping cough bacteria parasitise only humans. They cause a respiratory tract infection characterised by fits of coughing that end in loud inspiratory whoops. The infection is usually contracted in childhood and is potentially fatal in infancy. Adults are sometimes affected. The infection damages the epithelium lining the trachea and bronchi, impairing the beat of the cilia that keep the airways clean. Antibiotics are of very limited effect in treatment. Magnification: X 8800 at 35mm size. - Stock Image B220/0221
We report the repeated isolation of Bordetella petrii in the sputum of a 79-year-old female patient with diffuse bronchiectasis and persistence of the bacterium for >1 year. The patient was first hospitalized due to dyspnea, which developed into seve ...
There was a report out yesterday that the cases of whooping cough (Bordetella pertussis) in Minnesota have doubled from last month and by May, have exceeded all cases reported there last year. There have been 700 cases so far this … Continue reading →. ...
Biohazard level, growth media and temperature, gram stain, industrial applications and more information for Bordetella pertussis.
When and how often laboratory tests are done may depend on many factors. The timing of laboratory tests may rely on the results or completion of other tests, procedures, or treatments. Lab tests may be performed immediately in an emergency, or tests may be delayed as a condition is treated or monitored. A test may be suggested or become necessary when certain signs or symptoms appear. Due to changes in the way your body naturally functions through the course of a day, lab tests may need to be performed at a certain time of day. If you have prepared for a test by changing your food or fluid intake, lab tests may be timed in accordance with those changes. Timing of tests may be based on increased and decreased levels of medications, drugs or other substances in the body. The age or gender of the person being tested may affect when and how often a lab test is required. Chronic or progressive conditions may need ongoing monitoring through the use of lab tests. Conditions that worsen and improve may ...
... , BRONCHI-SHIELD ORAL is a unique Canine Infectious Respiratory Disease (CIRD) vaccine because it is the first live, avirulent Bordetella bronchiseptica vaccine licensed to be administered orally to
La tos ferina es una enfermedad del tracto respiratorio que se presenta exclusivamente en los seres humanos y es causada por la bacteria gramnegativa Bordetella pertusis.
The Sanger Institute has been funded by the Wellcome Trust to sequence the genomes of Bordetella pertussis strain Tohama I, B. parapertussis strain 12822 and B. bronchiseptica strain RB50 in collaboration with Duncan Maskell and Andrew Preston of the Centre for Veterinary Science, Dept. of Clinical Veterinary medicine, The University of Cambridge. The sequences and analysis are described in: Parkhill et al (2003) Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nature Genetics 35 32-40 (DOI: 10.1038/Ng1227), and have been submitted to EMBL/GenBank with the accession numbers: BX470248 (B. pertussis), BX470249 (B. parapertussis) and BX470250 (B. bronchiseptica). The three sequenced Bordetella strains have been deposited with the ATCC and NCTC under the following accession numbers: Bordetella parapertussis 12822: ATCC BAA-587, NCTC 13253 Bordetella bronchiseptica RB50: ATCC BAA-588, NCTC 13252 Bordetella pertussis Tohama ...
Using antisera raised against serotype 2 and 3 fimbrial subunits from Bordetella pertussis, serologically related polypeptides were detected in Bordetella bronchiseptica, Bordetella parapertussis and Bordetella avium strains. The two B. pertussis fimbrial subunits, and three of the serologically related B. bronchiseptica polypeptides, were shown to be very similar in amino ... read more acid composition and N-terminal amino acid sequence. Homology was observed between the N-termini of these polypeptides, and fimbrial subunits from Escherichia coli, Haemophilus influenzae and Proteus mirabilis. A synthetic oligonucleotide probe, derived from the N-terminal sequence of the B. pertussis serotype 2 fimbrial subunit, was used to identify fimbrial genes in genomic Southern blots. The results suggested the presence of multiple fimbrial subunit genes in B. pertussis, B. bronchiseptica and B. parapertussis. The DNA probe was used to clone one of the three tentative fimbrial subunit genes detected in B. ...
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Twelve specific pathogen-free (SPF) puppies were vaccinated intranasally with a bivalent, modified live vaccine against infectious tracheobronchitis (group 1) and six puppies of the same age and from the same source served as unvaccinated controls (group 2). Both groups were challenged with wild-type Bordetella bronchiseptica and canine parainfluenza virus by the aerosol route 56 weeks after group 1 had been vaccinated, and at the same time six 10-week-old SPF puppies from the same source (group 3) were also challenged. Oronasal swabs were taken regularly before and after the challenge, for the isolation of bacteria and viruses, and the dogs were observed for clinical signs for three weeks after the challenge. The control dogs became culture-positive for B bronchiseptica and canine parainfluenza virus, but the isolation yields from the vaccinated group were significantly lower (P,0·05). The mean clinical scores of the vaccinated group were 61 per cent lower than the scores of group 2 ...
Atrophic rhinitis usually occurs in late middle-aged to elderly patients. The cause of atrophic rhinitis is unknown, with the leading theory being age-related mucosal atrophy, sometimes complicated by secondary bacterial infection. Primary atrophic rhinitis resembles the rhinitis associated with Sjogrens syndrome or previous nasal surgery, including extensive turbinectomy. Examination generally reveals a patent nasal airway with atrophic, erythematous turbinates, despite the symptoms of congestion.. Some subjects with atrophic rhinitis report nasal congestion, crusting of the nasal airway, and a bad smell (ozena). Ozena is associated with bacterial overgrowth of the mucosa, particularly Klebseilla ozaenae and Pseudomonas aeruginosa. The appearance of ozena may resemble chronic granulomatous disease, such as Wegeners granulomatosis or sarcoidosis, or the effects of previous local irradiation. The prevalence of ozena is variable, with a greater occurrence in select geographic areas, such as ...
Methane is metabolized principally by methanotrophs and methanogens in the global carbon cycle. Methanotrophs consume methane as the only source of carbon, while methanogens produce methane as a metabolic byproduct. Methylotrophs, which are microorganisms that can obtain energy for growth by oxidizing one-carbon compounds, such as methanol and methane, are situated between methanotrophs and methanogens. Methanogens can obtain energy for growth by converting a limited number of substrates to methane under anaerobic conditions. Three types of methanogenic pathways are known: CO2 to methane [MD:M00567], methanol to methane [MD:M00356], and acetate to methane [MD:M00357]. Methanogens use 2-mercaptoethanesulfonate (CoM; coenzyme M) as the terminal methyl carrier in methanogenesis and have four enzymes for CoM biosynthesis [MD:M00358]. Coenzyme B-Coenzyme M heterodisulfide reductase (Hdr), requiring for the final reaction steps of methanogenic pathway, is divided into two types: cytoplasmic HdrABC in ...
Bordetella pertussis infection is being increasingly recognized as a cause of prolonged, distressing cough (without whooping symptoms) in children and young adults. Diagnosis of infection in this population is important for treatment and surveillance purposes, and may also prove useful in reducing transmission to unvaccinated babies, for whom disease can be fatal. Serum IgG titres against pertussis toxin (PT) are routinely used as a marker of recent or persisting B. pertussis infection. However, collection of serum from young children is difficult, and compliance amongst these subjects to give samples is low. To circumvent these problems, an IgG-capture ELISA capable of detecting anti-PT IgG in oral fluid was devised. The assay was evaluated by comparison to a serum ELISA, using 187 matched serum and oral fluid samples from children (aged 5-16 years) with a history of prolonged coughing, whose serum anti-PT titre had already been determined (69 seropositive, 118 seronegative). The results showed that,
Adenovirus 1 in canines causes respiratory infections, targets a number of organs within the physique, and causes infectious canine hepatitis (ICH), which is a illness that severely impacts the liver ... ...
These Pathogen Safety Data Sheets, regulated under Workplace Hazardous Materials Information System (WHMIS) legislation, are produced for personnel working in the life sciences as quick safety reference material relating to infectious micro-organisms.
This HIPRA UNIVERSITY course was notable for the participation of experts such as Pedro Lopes, founder and managing partner of the company PMS-Serviços Veterinários, Lda, and assistant professor at the Lusófona University (Lisbon, Portugal) and Enric Marco, owner of MARCO VETGRUP S. L. and internationally renowned consultant. HIPRA was represented by local teams from each country. The sessions included the most important theoretical aspects of the disease, such as its clinical presentations, diagnosis and vaccination as the principal method of prevention, with special emphasis on both progressive and non-progressive atrophic rhinitis. It is important to emphasize the role of Bordetella bronchiseptica as the causal agent of non-progressive atrophic rhinitis, that can also act as a predisposing factor for other respiratory disorders. The sessions also included a practical session that focussed on the evaluation of the nasal turbinates for diagnosis of the disease, during which attendees could ...
GENTILE, Ángela et al. Cost of Bordetella pertussis illness in tertiary hospitals in Argentina. Arch. argent. pediatr. [online]. 2013, vol.111, n.4, pp.295-302. ISSN 0325-0075. http://dx.doi.org/10.5546/aap.2013.295.. The National Immunization Commission and the National Program for the Control of Vaccine-Preventable Diseases (Programa Nacional de Control de Enfermedades Inmunoprevenibles, ProNaCEI) updated the immunization policy in relation to Bordetella pertussis (BP) in 2009 in order to improve the control of this disease in accordance with international recommendations. To evaluate the fnancial impact of this new immunization policy, we must frst know the cost on the health system of having a hospitalized or outpatient child infected with BP. The objective of this study was to describe the profle of costs of hospitalized or outpatient children with laboratory-confrmed BP infection in three hospitals of Argentina. This was a prospective study of the cost of BP in the period between December ...
Definition : Molecular assay reagents intended to identify species of Bordetella, a genus of gram-negative coccobacillus bacteria, by detecting specific nucleic-acid information of the target bacteria. Some species of these bacteria may cause infections in the human respiratory tract, including whooping cough.. Entry Terms : "Whooping Cough Diagnostic Reagents" , "Pertussis Diagnostic Reagents" , "Parapertussis Diagnostic Reagents" , "Bordetella Species Detection/Identification Reagents" , "Reagents, Molecular Assay, Infection, Bacteria, Bordetella Species". UMDC code : 21449 ...
In many countries inactivated vaccines to prevent Colibacilosis and atrophic rhinitis in pigs, are implemented during the sow gestation period. In Brasil Atrophic Rhinitis is an endemic and chronic disease, therefore most of the farms are vaccinating against this disease and against colibacilosis at the same time. This study show the safety in use of a mixture of SUISENG® (vaccine against the Neonatal Piglet Colibacillosis, C. perfringens and C. novyi enterotoxicosis) and RHINISENG® (Atrophic rhinitis vaccine) vaccines, inactivated vaccines against Colibacilosis-Clostridiosis and Atrophic rhinitis respectively.. ...
Escaneado de imágenes de microscopio electrónico de Bordetella pertussis - Gram-negativa, aerobia, no móviles, cocobacilos procariotas (bacterias) que causa la tosferina o pertussis. Sobre la técnica de imagen: Las tecnologías modernas tales como la microscopía electrónica puede dar detalles más finos de las bacterias que la microscopía óptica (luz) e incluso puede ser utilizado para mostrar las características internas. Las micrografías electrónicas son imágenes en blanco y negro generados por los rayos de alta energía de electrones. Las micrografías a veces se les da un color falso para que sean visualmente atractivo (en este caso, se utilizó un tinte verde).. ...
Catalytic and Structural Insights into Toxin Activation by the Bordetella pertussis CyaC-Acyltransferase av Dr. Niramon Thamwiriyasati Burapha University (BUU), Faculty of Allied Health Sciences, Chonburi, Thailand.
VetDepot offers Bronchicine, 10 Dose Vial at the most competitive prices. Get the best deals on all your pet meds at VetDepot. Bacterin recommended for the control of Canine Infectious Tracheobronchitis (Kennel Cough) caused by Bordetella Bronchiseptica.
Nobivac Intra-Trac3 ADT is for the prevention of Canine Adenovirus Type 2, Parainfluenza, Bordetella Bronchiseptica Vaccine (MLV). For INTRANASAL use in healthy dogs including pregnant females and healthy puppies.
0095] After the challenge with Bordetella bronchiseptica, general clinical observation was performed for each dog for 21 days, and its clinical symptoms were scored. The clinical scores were computed by scoring symptoms according to the following criteria every day during the observation period and adding them together. (1) Three points when body temperature (rectal temperature) is 40.0° C. or more, two points when 39.6 to 39.9° C., one point when 39.2 to 39.5° C.; (2) one point when hypodynamia is observed; (3) two points when serious anorexia is observed, one point when mild anorexia is observed; (4) one point when diarrhea is observed; (5) one point when vomiting is observed; (6) one point when dehydration is observed; (7) one point when lacrimation or eye discharge is observed in the eye; (8) three points when serious purulent nasal discharge is observed, two points when mild purulent nasal discharge is observed, one point when water-like nasal discharge is observed; (9) three points when ...
... is a vaccine that helps to protect against bacterial pneumonia and kennel cough. This is the vaccine that your dog generally gets administered by drops in the nose. There is also a vaccine that can be given under the skin via injection. Ask your veterinarian which vaccine is best for your dog. ...
If you have a definite diagnosis of Bordetella, ask if they know what ABs would work best for that strain and if they dont know, I would suggest putting the other pigs on a preventative course of trimethoprim/sulfa(30-50mg/kg q12h) or baytril(5-10mg/kg q12h) - Hillyer and Quesenberry. H&Q didnt mention how long a course. Doxy might also work but it isnt mentioned in Hillyer and Quesenberry probably because at the time of print of my book, it wasnt commonly used with pigs. A drug sensitivity culture would remove the guesswork ...
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Citation. Linz B, Ivanov YV, Preston A, Brinkac L, Parkhill J, Kim M, Harris SR, Goodfield LL, Fry NK, Gorringe AR, Nicholson TL, Register KB, Losada L, Harvill ET. Acquisition and Loss of Virulence-associated Factors During Genome Evolution and Speciation in Three Clades of Bordetella Species.. BMC Genomics. 2016 Sep 30; 17: 767.. External Citation. Abstract. The genus Bordetella consists of nine species that include important respiratory pathogens such as the classical species B. bronchiseptica, B. pertussis and B. parapertussis and six more distantly related and less extensively studied species. Here we analyze sequence diversity and gene content of 128 genome sequences from all nine species with focus on the evolution of virulence-associated factors.. ...
... ,The B. pertussis ASR contains primers and a FAM-labeled probe that is designed to detect a 103 bp region of the IS481 gene. In addition, the B. pertussis ASR contains primers, a Texas Red-labeled probe and DNA for an internal control sequence. This ASR requires an instrument that can detect FAM and,medicine,medical supply,medical supplies,medical product
The effect of an extract of histamine-sensitizing factor (HSF) of Bordetella pertussis on the immune response of different strains of mice to ovalbumin (OA) was investigated with regard to optimal dose of antigen and adjuvant. It was observed that all strains of mice treated with HSF during immunization with OA demonstrated enhanced production of hemagglutinating antibodies, as compared to animals treated with antigen alone. This enhancement was generally not as great as that demonstrated when Al(OH)3 was the adjuvant. HSF also stimulated a reaginic antibody response (IgE) to OA, but not in all strains of mice. In reagin responders optimal responses were observed with high doses of both antigen and adjuvant, whereas low doses of both produced little or no response. Maximal reagin production occurred usually 14-28 days after immunization and persisted for long periods of time. An anamnestic reagin response was elicited upon secondary immunization with antigen alone, not only in mice immunized ...
ICD-10 A37.00 is whooping cough due to bordetella pertussis without pneumonia (A3700). This code is grouped under diagnosis codes for certain infectious and parasitic diseases.
Morse, J.H.; Kong, A.S.; Lindenbaum, J.; Morse, S.I., 1977: The mitogenic effect of the lymphocytosis promoting factor from Bordetella pertussis on human lymphocytes
Yes! Vaccines against parainfluenza and adenovirus type 2 (in combination with other vaccines) are routinely used as part of an adult dogs yearly checkup. Puppies are usually vaccinated for these in combination with distemper, hepatitis, and parvovirus in a series of immunizations. Specific, non-routine vaccines are also available for Bordetella bronchiseptica (another cause of canine cough). Although some veterinary practices do not use this vaccination routinely, it should be considered for pets that board, visit a daycare frequently, or for those whose veterinarian recommends it. It is important to note that the vaccines that are used to prevent this viral disease are made from only one of the over 100 different strains of the virus and therefore are not as effective against some strains as others. Some strains are not included in any vaccine; therefore, there is no prevention against them. Your veterinarian is in the best position to recommend a program of preventative health care ...
Ready to use lyophilised master mixes (8-well strips each) for detection of feline calicivirus, feline herpesvirus-1, Bordetella bronchiseptica, Chlamydophila felis, Mycoplasma felis and internal control. ...
Pinta writes, "It isnt common with pigs but it does happen, and when it does its deadly. I know of 2 outbreaks, that killed the majority of the pigs. After symptoms of Bordetella show, it progresses incredibly rapidly. Watering eyes, puffed fur, and sitting with faces in the corner of the cage are just some of the symptoms I remember being related. Some of pigs died within hours of showing illness." ...
Study Flashcards On p-hemophilus bordetella, legionella at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Many known or suspected bacterial virulence factors require environmentally responsive control factors for expression. In Bordetella species, the BvgAS system represses and activates sets of genes, and mediates a biphasic phenotypic transition. Studies using mutants with altered signaling pathways and reversed regulatory connections have provided insights into the role of BvgAS and this phenotypic transition during the Bordetella-host interaction.
Abcam provides general protocols for Human Anti-Bordetella pertussis IgA ELISA Kit (ab108708). Please download our pdf protocol booklet
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed ...
That ET tube is going down the patients hatch, so disinfect it like crazy. Here are five cleaning methods going head-to-head in fighting strep and Bordetella in a new study ...
Citation: Brockmeier, S., Register, K.B. 2007. Expression of the dermonecrotic toxin by Bordetella bronchiseptica is not necessary for predisposing to infection with toxigenic Pasteurella multocida. Veterinary Microbiology. 125(3-4):284-289. Interpretive Summary: Infection with Bordetella bronchiseptica predisposes pigs to infection with Pasteurella multocida, and coinfection with these agents is often found in cases of progressive atrophic rhinitis, a disease which causes deformed growth of the pigs snout. There are several potential mechanisms by which B. bronchiseptica could predispose to infection with P. multocida. B. bronchiseptica produces a toxin called the dermonecrotic toxin, or DNT, which induces damage to swine nasal tissue and causes pneumonia and could play a role in increased colonization by P. multocida. This experiment was designed to determine whether a strain of B. bronchiseptica which does not produce DNT is still capable of predisposing pigs to infection with P. multocida. ...
OBJECTIVE: To study the clinical presentation of culture-confirmed pertussis in children and their contacts with cough illnesses in an outpatient setting. METHODOLOGY: In conjunction with a large pertussis vaccine efficacy trial in Germany, a central laboratory to isolate Bordetella species from nasopharyngeal specimens was established in Erlangen in October 1990. Pediatricians in private practices in southern Germany, the Saar region, and Berlin were encouraged to obtain nasopharyngeal specimens and clinical characteristics from patients with cough illnesses ,/=7 days duration. Bordetella species were isolated by use of calcium alginate swabs, Regan-Lowe agar, and modified Stainer-Scholte broth. Clinical characteristics were determined by initial and follow-up questionnaires. RESULTS: From October 1990 to September 1996, 20 972 specimens were submitted, and B pertussis was isolated in 2592 instances (12.4%). Of the culture-proven cases, 50.7% were female, and the age range was 6 days to 41 ...
Ca2 Influx and Tyrosine Kinases Trigger Bordetella Adenylate Cyclase Toxin ACT Endocytosis. Cell Physiology and Expression of the CD11b-CD18 Integrin Major Determinants of the Entry Route. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Bordetella pertussis is the causative agent of human whooping cough (pertussis) and is particularly severe in infants. Despite worldwide vaccinations, whooping cough remains a public health problem. A significant increase in the incidence of whooping cough has been observed in many countries since the 1990s. Several reasons for the re-emergence of this highly contagious disease have been suggested. A particularly intriguing possibility is based on evidence indicating that pathogen adaptation may play a role in this process. In an attempt to gain insight into the genomic make-up of B. pertussis over the last 60 years, we used an oligonucleotide DNA microarray to compare the genomic contents of a collection of 171 strains of B. pertussis isolates from different countries. The CGH microarray analysis estimated the core genome of B. pertussis, to consist of 3,281 CDSs that are conserved among all B. pertussis strains, and represent 84.8% of all CDSs found in the 171 B. pertussis strains. A total of 64
Gearing, A.J.; Bird, C.; Wadha, M.; Redhead, K., 1987: The primary and secondary cellular immune responses to whole cell Bordetella pertussis vaccine and its components
Non-core vaccinations include that for Bordetella bronchiseptica, which is usually required by boarding facilities, obedience classes, dog shows and other places where the highly contagious kennel cough can spread. If your dog is often exposed to bodies of water -- ranging from streams to lakes -- your vet may recommend a vaccine against leptospirosis. This bacterial infection, which can prove fatal in some cases, is also spread via contaminated urine and can remain in the soil. If you travel a lot with your pet, or participate in dog shows, the canine influenza virus vaccine is recommended. While a vaccine is available for Lyme disease, many vets dont suggest it for their patients unless the dogs lifestyle puts him at particular risk for this debilitating disease.. ...
Bordetella vaccine is given to aid in the prevention of "Kennel Cough", the most prevalent upper respiratory problem in dogs in the United States. The condition is also known as tracheobronchitis, canine infectious tracheobronchitis, Bordetellosis, or Bordetella. It is highly contagious in dogs. The disease is found worldwide and will infect a very high percentage of dogs in their lifetime ...
Pertussis (also known as whooping cough) continues to be a global health problem with an estimated 45 million cases annually and 300,00 deaths, which occur most...
ECDC is addressing the harmonisation and improvement of pertussis diagnosis for surveillance and outbreak detection/monitoring in order to assure quality and comparability of data. The guidance and protocol are intended for real-time PCR on DNA extracted from clinical specimens obtained from patients with suspected whooping cough (i.e. Bordetella pertussis or B. parapertussis). ...
ECDC is addressing the harmonisation and improvement of pertussis diagnosis for surveillance and outbreak detection/monitoring in order to assure quality and comparability of data. The guidance and protocol are intended for real-time PCR on DNA extracted from clinical specimens obtained from patients with suspected whooping cough (i.e. Bordetella pertussis or B. parapertussis). ...
Background: Re-emergence of pertussis has been reported in Iran despite a high rate of vaccination coverage. Low efficacy of the vaccine might be due
Mooi FR; van Loo IHM; van Gent M; He Q; Bart MJ; Heuvelman KJ; de Greeff SC; Diavatopoulos D; Teunis P; Nagelkerke N; Mertsola J (2009 ...
Check back here often for information about vaccines needed to keep your pets safe while at home and on the go. Canine Flu Vaccination It is always fun to take our pups with us while traveling. We want to make sure they are protected from diseases that can make them sick. Canine Infectious respiratory disease Continue reading. ...
Adenylate cyclase toxin (CyaA) from Bordetella pertussis can subvert host immune responses allowing bacterial colonization. Here we have examined its adjuvant and immunomodulatory properties and the possible contribution of lipopolysaccharide (LPS), known to be present in purified CyaA preparations. CyaA enhanced antigen-specific interleukin-5 (IL-5) and IL-10 production and immunoglobulin G1 antibodies to coadministered antigen in vivo. Antigen-specific CD4+-T-cell clones generated from mice immunized with antigen and CyaA had cytokine profiles characteristic of Th2 or type 1 regulatory T (Tr1) cells. Since innate immune cells direct the induction of T-cell subtypes, we examined the influence of CyaA on activation of dendritic cells (DC) and macrophages. CyaA significantly augmented LPS-induced IL-6 and IL-10 and inhibited LPS-driven tumor necrosis factor alpha and IL-12p70 production from bone marrow-derived DC and macrophages. CyaA also enhanced cell surface expression of CD80, CD86, and ...
Wehmann E, Khayer B, Magyar T (2015) Heterogeneity of Bordetella bronchiseptica adenylate cyclase (cyaA) RTX domain. Arch Microbiol. 197(1): 105-112. doi: 10.1007/s00203-014-1068-x. Magyar T, Donkó T, Repa I, Kovács M (2013) Regeneration of toxigenic Pasteurella multocida induced severe turbinate atrophy in pigs detected by computed tomography. BMC Vet Res. 9: 222. doi: 10.1186/1746-6148-9-222. Sellyei B, Wehmann E, Magyar T (2012) Sequencing-independent method for the differentiation of the main phylogenetic lineages of Pasteurella multocida. J Vet Diagn Invest. 24(4): 735-738. doi: 10.1177/1040638712447794. Pósa R, Donkó T, Bogner P, Kovács M, Repa I, Magyar T (2011) Interaction of Bordetella bronchiseptica, Pasteurella multocida, and fumonisin B1 in the porcine respiratory tract as studied by computed tomography. Can J Vet Res. 75(3): 176-182.. Sellyei B, Wehmann E, Makrai L, Magyar T (2011) Evaluation of the Biolog system for the identification of certain closely related Pasteurella ...
BD Difco™ Fluorescent Antibody Reagents FA Bordetella Pertussis; 5mL BD Difco™ Fluorescent Antibody Reagents Antibody Binding Proteins and...

Bordetella parapertussis | World eBook Library | Read eBooks onlineBordetella parapertussis | World eBook Library | Read eBooks online

Bordetella parapertussis, , , ... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, ... "The O Antigen Enables Bordetella parapertussis To Avoid Bordetella pertussis-Induced Immunity". Infection and Immunity 75 (10 ... Bordetella parapertussis is a small Gram-negative bacterium of the genus Bordetella that is adapted to colonise the mammalian ... "Predisposition of specific pathogen-free lambs to Pasteurella haemolytica pneumonia by Bordetella parapertussis infection". J ...
more infohttp://ebook.worldlibrary.net/articles/eng/Bordetella_parapertussis

Bordetella - Wellcome Sanger InstituteBordetella - Wellcome Sanger Institute

It causes chronic and often asymptomatic respiratory infections in a wide range of animals, but only occasionally in humans. A ... Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.. ... Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. B. pertussis, and occasionally B. parapertussis, ... Bordetella parapertussis 12822: ATCC BAA-587, NCTC 13253 Bordetella bronchiseptica RB50: ATCC BAA-588, NCTC 13252 Bordetella ...
more infohttp://www.sanger.ac.uk/resources/downloads/bacteria/bordetella.html

Bordetella adenylate cyclase toxin: the role of cell interaction in toxin functio - Joshua EbyBordetella adenylate cyclase toxin: the role of cell interaction in toxin functio - Joshua Eby

... is necessary for disease caused by Bordetella pertussis, which has reemerged in the United States over the last two decad... ... 2013) Quantification of the adenylate cyclase toxin of Bordetella pertussis in vitro and during respiratory infection. Infect ... Bordetella adenylate cyclase toxin: the role of cell interaction in toxin functio Eby, Joshua Clark University of Virginia, ... Bordetella adenylate cyclase toxin: the role of cell interaction in toxin functio. Eby, Joshua Clark / University of Virginia. ...
more infohttp://grantome.com/grant/NIH/K08-AI081900-05

Bordetella avium | Article about Bordetella avium by The Free DictionaryBordetella avium | Article about Bordetella avium by The Free Dictionary

A nonsporulating, gram-negative coccobacillus that causes respiratory infections in birds Explanation of Bordetella avium ... Looking for Bordetella avium? Find out information about Bordetella avium. ... Related to Bordetella avium: Bordetella bronchiseptica, Bordetella hinzii, Alcaligenes faecalis Bordetella avium. [‚bȯr·də‚tel· ... Bordetella avium is thought to be strictly an avian pathogen.. Prevalence of Bordetella avium infection in selected wild and ...
more infohttps://encyclopedia2.thefreedictionary.com/Bordetella+avium

The primary and secondary cellular immune responses to whole cell Bordetella pertussis vaccine and its componentsThe primary and secondary cellular immune responses to whole cell Bordetella pertussis vaccine and its components

In the present study, protection against Bordetella pertussis infection and humoral immunological responses in mice has been ... In the present study, protection against Bordetella pertussis infection and humoral immunological responses in mice has been ... and agglutinogens 2 and 3 after infection with Bordetella pertussis and immunization with whole-cell pertussis vaccine. Class ... Protection and humoral immune responses against Bordetella pertussis infection in mice immunized with acellular or cellular ...
more infohttps://eurekamag.com/research/006/740/006740700.php

Construction of a Heterologous Vaccine against Bordetella avium and Ca by Rachel Korba"Construction of a Heterologous Vaccine against Bordetella avium and Ca" by Rachel Korba

... jejuni in poultry is difficult because it is part of the natural flora and does not cause symptomatic infection. In a related ... often leading to secondary infections. The aim of this project was to construct a vaccine platform capable of immunizing ... manner, Bordetella avium is a Gram negative species of bacteria that causes bordetellosis in poultry. This disease is similar ... In a related manner, Bordetella avium is a Gram negative species of bacteria that causes bordetellosis in poultry. This disease ...
more infohttp://commons.lib.jmu.edu/honors201019/259/

Bordetella infection - Oxford MedicineBordetella infection - Oxford Medicine

... of which Bordetella pertussis is the most important human pathogen. It is the cause of whooping cough, which is one of the 10 ... immunization and previous infection: (1) infants-apnoea, cyanosis, and paroxysmal cough; (2) nonimmunized children-cough, ... Bordetella infection Bordetella infection. Chapter:. Bordetella infection. Author(s):. Cameron Grant. DOI:. 10.1093/med/ ... Description of Bordetella species updated to include Bordetella hinzii, B. trematum, and B. petrii. ...
more infohttp://oxfordmedicine.com/view/10.1093/med/9780199204854.001.1/med-9780199204854-chapter-070614

Bordetella Pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective...Bordetella Pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective...

Bordetella Pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective ... Incidence of Bordetella pertussis infection in adolescents and adults. [Clin Infect Dis. 2007] ... Infection rates were determined with a variety of serologic criteria for control and vaccinated subjects. The incidence of ... Asymptomatic infections were approximately 5 times more common than clinical illnesses that met a strict clinical and ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/16779740?dopt=Abstract

Bordetella bronchiseptica infection in catteries and rescue sheltersBordetella bronchiseptica infection in catteries and rescue shelters

Bordetella bronchiseptica infections are an important cause for upper tract respiratory disease (URTD) in catteries and rescue ... Bordetella bronchiseptica infection in catteries and rescue shelters. Anyone with experience of cats knows the importance of ... Cat flu is not caused by a single bug but the term describes similar signs caused by infection with one or more different bugs ... Recent research into respiratory diseases of cats has revealed the importance of a new bug: Bordetella bronchiseptica (more ...
more infohttp://www.nobivacbb.com/catteries/default.asp

A Randomized, Placebo-Controlled Trial of Erythromycin Estolate Chemoprophylaxis for Household Contacts of Children With...A Randomized, Placebo-Controlled Trial of Erythromycin Estolate Chemoprophylaxis for Household Contacts of Children With...

Erythromycin Estolate Chemoprophylaxis for Household Contacts of Children With Culture-Positive Bordetella pertussis Infection ... Comparison of 7 and 14 days of erythromycin estolate treatment of B pertussis infection.23 ... Erythromycin Estolate Chemoprophylaxis for Household Contacts of Children With Culture-Positive Bordetella pertussis Infection ... Erythromycin Estolate Chemoprophylaxis for Household Contacts of Children With Culture-Positive Bordetella pertussis Infection ...
more infohttps://pediatrics.aappublications.org/content/104/4/e42.figures-only

Immunization with the Recombinant Cholera Toxin B Fused to Fimbria 2 Protein Protects against Bordetella pertussis Infection.Immunization with the Recombinant Cholera Toxin B Fused to Fimbria 2 Protein Protects against Bordetella pertussis Infection.

... in the intranasal murine model of infection. To this end B. pertussis Fim2 coding sequence was cloned downstre ... This study examined the immunogenic properties of the fusion protein fimbria 2 of Bordetella pertussis (Fim2)-cholera toxin B ... The data presented here provide support for CTB-Fim2 as a promising recombinant antigen against Bordetella pertussis infection. ... This study examined the immunogenic properties of the fusion protein fimbria 2 of Bordetella pertussis (Fim2)-cholera toxin B ...
more infohttp://www.biomedsearch.com/nih/Immunization-with-Recombinant-Cholera-Toxin/24982881.html

Prevention and control of Bordetella bronchiseptica infection in catsPrevention and control of Bordetella bronchiseptica infection in cats

An intranasal vaccine is available which can be added to vaccination schedules to help prevent URTD caused by Bordetella ... Since Bordetella bronchiseptica infection in kittens can cause acute death as a result of bronchopneumonia, this risk must be ... Prevention and control of Bordetella bronchiseptica infection in cats. Until now prevention of feline upper respiratory tract ... During parturition, queens may pass Bordetella bronchiseptica to their offspring; kittens obtained from breeding catteries and ...
more infohttp://www.nobivacbb.com/bordetella/control/default.asp

Macrolide-Resistant Bordetella pertussis Infection in Newborn Girl, France - Volume 18, Number 6-June 2012 - Emerging...Macrolide-Resistant Bordetella pertussis Infection in Newborn Girl, France - Volume 18, Number 6-June 2012 - Emerging...

On day 23 of hospitalization, macrolide-resistant Bordetella pertussis was isolated from nasopharyngeal aspirates. DNA ... Co-infection with two different strains of Bordetella pertussis in an infant. J Med Microbiol. 2008;57:388-91. DOIPubMed ... Macrolide-Resistant Bordetella pertussis Infection in Newborn Girl, France. Emerging Infectious Diseases. 2012;18(6):966-968. ... Macrolide-Resistant Bordetella pertussis Infection in Newborn Girl, France On This Page ...
more infohttps://wwwnc.cdc.gov/eid/article/18/6/12-0091_article

Macrolide-Resistant Bordetella pertussis Infection in Newborn Girl, France - Volume 18, Number 6-June 2012 - Emerging...Macrolide-Resistant Bordetella pertussis Infection in Newborn Girl, France - Volume 18, Number 6-June 2012 - Emerging...

On day 23 of hospitalization, macrolide-resistant Bordetella pertussis was isolated from nasopharyngeal aspirates. DNA ... Co-infection with two different strains of Bordetella pertussis in an infant. J Med Microbiol. 2008;57:388-91. DOIPubMed ... Macrolide-Resistant Bordetella pertussis Infection in Newborn Girl, France. Emerging Infectious Diseases. 2012;18(6):966-968. ... Macrolide-Resistant Bordetella pertussis Infection in Newborn Girl, France On This Page ...
more infohttps://wwwnc.cdc.gov/eid/article/18/6/12-0091

Comparison of Serological and Real-Time PCR Assays To Diagnose Bordetella pertussis Infection in 2007 | Journal of Clinical...Comparison of Serological and Real-Time PCR Assays To Diagnose Bordetella pertussis Infection in 2007 | Journal of Clinical...

Comparison of Serological and Real-Time PCR Assays To Diagnose Bordetella pertussis Infection in 2007 Philippe André, Valerie ... Nucleic acid amplification tests for diagnosis of Bordetella infections. J. Clin. Microbiol. 43:4925-4929. ... The incidence of Bordetella pertussis infections estimated in the population from a combination of serological surveys. J. ... Bordetella pertussis and Bordetella parapertussis: two immunologically distinct species. Infect. Immun. 61:486-490. ...
more infohttps://jcm.asm.org/content/46/5/1672?ijkey=712d85a4dbfbe3963d9e37e2d3773d21a1fce873&keytype2=tf_ipsecsha

The efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis...The efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis...

... efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis infections in ... efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis infections in ...
more infohttps://www.rivm.nl/Documenten_en_publicaties/Wetenschappelijk/Wetenschappelijke_artikelen/1998/april/The_efficacy_of_a_whole_cell_pertussis_vaccine_and_fimbriae_against_Bordetella_pertussis_and_Bordetella_parapertussis_infections_in_a_respiratory_mouse_model

Frequency of Serological Evidence of Bordetella Infections and Mixed Infections with other Respiratory Pathogens in University...Frequency of Serological Evidence of Bordetella Infections and Mixed Infections with other Respiratory Pathogens in University...

... influenza A infections, 3; C. pneumoniae infections, 3; and M. pneumoniae infections, 2). Our findings suggest that bordetella ... Seventeen (36%) had evidence of mixed infections or cross-reacting antibodies (influenza B infections, 5; adenovirus infections ... pertussis infection, and 2 (1%) had evidence of non-B. pertussis bordetella infections. ... Chlamydia pneumoniae infections were diagnosed by culture or by a ≥4-fold increase in immunofluorescence assay titer or a ...
more infohttp://oxfordindex.oup.com/view/10.1086/313911

Surface-associated filamentous hemagglutinin induces autoagglutination of Bordetella pertussis. | Infection and ImmunitySurface-associated filamentous hemagglutinin induces autoagglutination of Bordetella pertussis. | Infection and Immunity

Surface-associated filamentous hemagglutinin induces autoagglutination of Bordetella pertussis.. F D Menozzi, P E Boucher, G ... Surface-associated filamentous hemagglutinin induces autoagglutination of Bordetella pertussis.. F D Menozzi, P E Boucher, G ... Surface-associated filamentous hemagglutinin induces autoagglutination of Bordetella pertussis.. F D Menozzi, P E Boucher, G ... Thank you for sharing this Infection and Immunity article.. NOTE: We request your email address only to inform the recipient ...
more infohttps://iai.asm.org/content/62/10/4261/article-info

Polymerase chain reaction identification of Bordetella pertussis infections in vaccinees and family members in a pertussis...Polymerase chain reaction identification of Bordetella pertussis infections in vaccinees and family members in a pertussis...

... was recently added to conventional culture and serology for the diagnosis of Bordetella pertussis infection in a large vaccine ... Polymerase chain reaction identification of Bordetella pertussis infections in vaccinees and family members in a pertussis ... was recently added to conventional culture and serology for the diagnosis of Bordetella pertussis infection in a large vaccine ...
more infohttps://insights.ovid.com/pediatric-infectious-disease/pidj/1995/03/000/polymerase-chain-reaction-identification/8/00006454

Host Genetics of Bordetella pertussis Infection in Mice: Significance of Toll-Like Receptor 4 in Genetic Susceptibility and...Host Genetics of Bordetella pertussis Infection in Mice: Significance of Toll-Like Receptor 4 in Genetic Susceptibility and...

Host Genetics of Bordetella pertussis Infection in Mice: Significance of Toll-Like Receptor 4 in Genetic Susceptibility and ... Host Genetics of Bordetella pertussis Infection in Mice: Significance of Toll-Like Receptor 4 in Genetic Susceptibility and ... Home/Host Genetics of Bordetella pertussis Infection in Mice: Significance of Toll-Like Receptor 4 in Genetic Susceptibility ... The susceptibility to and the severity of Bordetella pertussis infections in infants and children varies widely, suggesting ...
more infohttps://www.synbiosis.com/technical-paper/host-genetics-bordetella-pertussis-infection-mice-significance-toll-like-receptor-4-genetic-susceptibility-pathobiology/

Bordetella pertussis infection causing pulmonary hypertension | Read by QxMDBordetella pertussis infection causing pulmonary hypertension | Read by QxMD

Bordetella pertussis infection causing pulmonary hypertension. P Casano, M Pons Odena, F J Cambra, J M Martín, A Palomeque ... Pathology and pathogenesis of fatal Bordetella pertussis infection in infants. Christopher D Paddock, Gary N Sanden, James D ... Successful treatment of ARDS and severe pulmonary hypertension in a child with Bordetella pertussis infection. Daniela Skladal ... Pertussis infection and fatal pulmonary hypertension]. K Menif, A Bouziri, A Khaldi, A Hamdi, S Belhadj, N Benjaballah Archives ...
more infohttps://read.qxmd.com/read/12023188/bordetella-pertussis-infection-causing-pulmonary-hypertension

Identification and purification of transferrin- and lactoferrin-binding proteins of Bordetella pertussis and Bordetella...Identification and purification of transferrin- and lactoferrin-binding proteins of Bordetella pertussis and Bordetella...

Thank you for sharing this Infection and Immunity article.. NOTE: We request your email address only to inform the recipient ... Bordetella pertussis and Bordetella bronchiseptica were both able to grow in iron-deficient medium when supplemented with iron- ... Identification and purification of transferrin- and lactoferrin-binding proteins of Bordetella pertussis and Bordetella ... Identification and purification of transferrin- and lactoferrin-binding proteins of Bordetella pertussis and Bordetella ...
more infohttps://iai.asm.org/content/59/11/3982?ijkey=7af21a55c75d8e2e92a192bd496eccefabcac906&keytype2=tf_ipsecsha

Guidance and protocol for the use of real-time PCR in laboratory diagnosis of human infection with Bordetella pertussis or...Guidance and protocol for the use of real-time PCR in laboratory diagnosis of human infection with Bordetella pertussis or...

Guidance and protocol for the use of real-time PCR in laboratory diagnosis of human infection with Bordetella pertussis or ... Guidance and protocol for the use of real-time PCR in laboratory diagnosis of human infection with Bordetella pertussis or ... infection with Bordetella pertussis or B. parapertussis).. Both documents have been produced by the members of the European ... for diagnosis of bordetella infections.. The former document is a consensus document on laboratory guidance for the ...
more infohttps://www.ecdc.europa.eu/en/publications-data/guidance-and-protocol-use-real-time-pcr-laboratory-diagnosis-human-infection

reagents-molecular-assay-infection-bacteria-bordetella-species-dnareagents-molecular-assay-infection-bacteria-bordetella-species-dna

IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Bordetella Species, DNA. Definition : Molecular assay reagents ... Home > Specialties > IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Bordetella Species, DNA ... Some species of these bacteria may cause infections in the human respiratory tract, including whooping cough. ... intended to identify species of Bordetella, a genus of gram-negative coccobacillus bacteria, by detecting specific genetic ...
more infohttp://productguide.ophthalmologymanagement.com/term/6802/reagents-molecular-assay-infection-bacteria-bordetella-species-dna

Pathology and pathogenesis of fatal Bordetella pertussis infection in infants | Read by QxMDPathology and pathogenesis of fatal Bordetella pertussis infection in infants | Read by QxMD

Fatal Bordetella pertussis infection: report of two cases with novel pathologic findings. R Hackman, D G Perrin, M Karmali, E ... Pathology and pathogenesis of fatal Bordetella pertussis infection in infants. Christopher D Paddock, Gary N Sanden, James D ... BACKGROUND: Each year, Bordetella pertussis infection causes an estimated 294,000 deaths worldwide, primarily among young, ... A controlled study of the relationship between Bordetella pertussis infections and sudden unexpected deaths among German ...
more infohttps://read.qxmd.com/read/18558873/pathology-and-pathogenesis-of-fatal-bordetella-pertussis-infection-in-infants
  • We have used recombinant congenic mouse strains (RCS) as a tool to facilitate the mapping of low-penetrance quantitative trait loci that control complex traits such as a B. pertussis infection [ 7 ]. (beds.ac.uk)
  • In conclusion, Tlr4 is a major host factor explaining the differences in the course of infection between these inbred strains of mice. (synbiosis.com)
  • HcB-28 mice are more resistant to B. pertussis infection than C3H mice, which could partially be ascribed to the B . pertussis susceptibility locus-1 ( Bps1 ) on chromosome 12. (beds.ac.uk)
  • To further elucidate the role of host genetic factors, in particular in the Bps1 locus, in B. pertussis infection, and to identify candidate genes within in this region, we compared expression profiles in the lungs of the C3H and HcB-28 mouse strains following B. pertussis inoculation. (beds.ac.uk)
  • Especially Bps1 displayed strong linkage with susceptibility to B. pertussis infection. (beds.ac.uk)
  • Because the genes that were differentially regulated between the mouse strains only showed differences in expression before infection, it appears likely that such intrinsic differences in gene regulation are involved in determining differences in susceptibility to B. pertussis infection. (beds.ac.uk)
  • Bacterial culture for diagnosing pertussis infection has high specificity but poor sensitivity and is slow. (asm.org)
  • Our results showed that bacterial infection was completely abrogated in treated mice when the LPS of B. pertussis (1 g) was added before (48 h or 24 h), after (24 h), or simultaneously with the B. pertussis challenge (107 CFU). (conicet.gov.ar)
  • Moreover, we detected that LPS completely cleared bacterial infection as soon as 2 h posttreatment. (conicet.gov.ar)
  • Bb infection induced lung dysbiosis, characterized by high bacterial load, low richness and diversity and increased abundance of Bb , compared with healthy dogs. (biomedcentral.com)
  • The exacerbated induction of innate immune responses in airways can abrogate diverse lung infections by a phenomenon known as stimulated innate resistance (StIR). (conicet.gov.ar)
  • Studies about the canine lung microbiota (LM) are recent, sparse, and only one paper has been published in canine lung infection. (biomedcentral.com)
  • Mycoplasma pneumoniae , influenza A and B, adenovirus, and respiratory syncytial virus infections were diagnosed by ≥4-fold increases in complement fixation titer or a single high titer (≥64). (oup.com)
  • TNF-α expression in the lungs 3 days after infection was increased fivefold compared to uninfected controls in A/J mice and was not affected in C3H/HeJ mice. (synbiosis.com)
  • Cat flu is not caused by a single bug but the term describes similar signs caused by infection with one or more different bugs. (nobivacbb.com)