Infections with bacteria of the genus BORDETELLA.
A genus of gram-negative, aerobic bacteria whose cells are minute coccobacilli. It consists of both parasitic and pathogenic species.
A species of BORDETELLA that is parasitic and pathogenic. It is found in the respiratory tract of domestic and wild mammalian animals and can be transmitted from animals to man. It is a common cause of bronchopneumonia in lower animals.
A species of BORDETELLA with similar morphology to BORDETELLA PERTUSSIS, but growth is more rapid. It is found only in the RESPIRATORY TRACT of humans.
A species of gram-negative, aerobic bacteria that is the causative agent of WHOOPING COUGH. Its cells are minute coccobacilli that are surrounded by a slime sheath.
A set of BACTERIAL ADHESINS and TOXINS, BIOLOGICAL produced by BORDETELLA organisms that determine the pathogenesis of BORDETELLA INFECTIONS, such as WHOOPING COUGH. They include filamentous hemagglutinin; FIMBRIAE PROTEINS; pertactin; PERTUSSIS TOXIN; ADENYLATE CYCLASE TOXIN; dermonecrotic toxin; tracheal cytotoxin; Bordetella LIPOPOLYSACCHARIDES; and tracheal colonization factor.
A species of BORDETELLA isolated from the respiratory tracts of TURKEYS and other BIRDS. It causes a highly contagious bordetellosis.
A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)
Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.
One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLYL CYCLASES and hemolysin components.
One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.
A chronic inflammation in which the NASAL MUCOSA gradually changes from a functional to a non-functional lining without mucociliary clearance. It is often accompanied by degradation of the bony TURBINATES, and the foul-smelling mucus which forms a greenish crust (ozena).
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
A respiratory infection caused by BORDETELLA PERTUSSIS and characterized by paroxysmal coughing ending in a prolonged crowing intake of breath.
Delivery of medications through the nasal mucosa.
A bluish or purplish discoloration of the skin and mucous membranes due to an increase in the amount of deoxygenated hemoglobin in the blood or a structural defect in the hemoglobin molecule.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria normally found in the flora of the mouth and respiratory tract of animals and birds. It causes shipping fever (see PASTEURELLOSIS, PNEUMONIC); HEMORRHAGIC BACTEREMIA; and intestinal disease in animals. In humans, disease usually arises from a wound infection following a bite or scratch from domesticated animals.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.

Probing the function of Bordetella bronchiseptica adenylate cyclase toxin by manipulating host immunity. (1/236)

We have examined the role of adenylate cyclase-hemolysin (CyaA) by constructing an in-frame deletion in the Bordetella bronchiseptica cyaA structural gene and comparing wild-type and cyaA deletion strains in natural host infection models. Both the wild-type strain RB50 and its adenylate cyclase toxin deletion (DeltacyaA) derivative efficiently establish persistent infections in rabbits, rats, and mice following low-dose inoculation. In contrast, an inoculation protocol that seeds the lower respiratory tract revealed significant differences in bacterial numbers and in polymorphonuclear neutrophil recruitment in the lungs from days 5 to 12 postinoculation. We next explored the effects of disarming specific aspects of the immune system on the relative phenotypes of wild-type and DeltacyaA bacteria. SCID, SCID-beige, or RAG-1(-/-) mice succumbed to lethal systemic infection following high- or low-dose intranasal inoculation with the wild-type strain but not the DeltacyaA mutant. Mice rendered neutropenic by treatment with cyclophosphamide or by knockout mutation in the granulocyte colony-stimulating factor locus were highly susceptible to lethal infection by either wild-type or DeltacyaA strains. These results reveal the significant role played by neutrophils early in B. bronchiseptica infection and by acquired immunity at later time points and suggest that phagocytic cells are a primary in vivo target of the Bordetella adenylate cyclase toxin.  (+info)

Evidence of efficacy of the Lederle/Takeda acellular pertussis component diphtheria and tetanus toxoids and pertussis vaccine but not the Lederle whole-cell component diphtheria and tetanus toxoids and pertussis vaccine against Bordetella parapertussis infection. (2/236)

A subanalysis of a recent cohort efficacy trial of a pertussis vaccine was performed to determine its efficacy against cough illnesses due to Bordetella parapertussis infections. Infants received four doses of either the Lederle/Takeda acellular pertussis component diphtheria and tetanus toxoids and pertussis (DTaP) vaccine or the Lederle whole-cell component diphtheria and tetanus toxoids and pertussis (DTP) vaccine at 3, 4.5, 6, and 15-18 months of age; controls received three doses of diphtheria and tetanus toxoids (DT) vaccine only. All subjects were prospectively followed for cough illnesses of > or = 7 days' duration; cases of B. parapertussis infection were confirmed by positive culture, household contact, or serology. Seventy-six cough illnesses due to B. parapertussis were identified; 24 occurred in 929 DTaP recipients, 37 in 937 DTP recipients, and 15 in 321 DT recipients, resulting in an efficacy of 50% for DTaP vaccine (95% CI [confidence interval], 5% to 74%) and 21% for DTP vaccine (95% CI, -45% to 56%). The data in the present analysis suggest that the Lederle/Takeda DTaP vaccine but not the Lederle whole-cell component DTP vaccine has efficacy against B. parapertussis infection.  (+info)

Outcomes of Bordetella infections in vaccinated children: effects of bacterial number in the nasopharynx and patient age. (3/236)

Five outbreaks of infection (three pertussis, one parapertussis, and one mixed) in schools were studied prospectively. Nasopharyngeal swabs were obtained from a total of 697 children for culture of Bordetella organisms. Of 50 vaccinated children with culture-confirmed Bordetella infections (29 with pertussis and 21 parapertussis), 40 were symptomatic and 10 remained symptom-free. Smaller numbers of colonies were recovered from the nasopharyngeal swabs of the asymptomatic children than from those of the symptomatic children. Older children had longer durations of illness than younger ones. Our results indicate that during outbreaks children who do not develop disease may have small amounts of Bordetella organisms in their nasopharynges and/or better immune defenses against the disease.  (+info)

Bordetella bronchiseptica infection in human immunodeficiency virus-infected patients. (4/236)

Bordetella bronchiseptica is a pleomorphic gram-negative coccobacillus that commonly causes respiratory tract infections in dogs. We identified nine human immunodeficiency virus (HIV)-infected persons with culture-confirmed B. bronchiseptica infections (eight respiratory tract and one disseminated infection). The respiratory illnesses ranged in severity from mild upper respiratory tract infection to pneumonia. All nine patients had had at least one AIDS-defining condition before the B. bronchiseptica infection. Two patients had household contact with dogs before their illnesses, and one had household contact with cats. Infection due to B. bronchiseptica is uncommon in HIV-infected persons. Additional data are needed to fully define the spectrum of disease due to B. bronchiseptica infections and to evaluate the possibility that this infection may be acquired from pets. Treatment of B. bronchiseptica infection should be tailored to the patient and should be based on the results of susceptibility testing.  (+info)

Parapertussis and pertussis: differences and similarities in incidence, clinical course, and antibody responses. (5/236)

OBJECTIVES: To compare the incidence, clinical course, and serologic response to Bordetella antigens in patients with parapertussis and pertussis. DESIGN: Two studies were performed in Sweden during the 1990s, when pertussis vaccines were used only in clinical trials. Study I was a retrospective study of patients with positive Bordetella cultures obtained in clinical routine, and study II involved an active search for patients with Bordetella infections during a placebo-controlled trial of a pertussis toxoid vaccine. RESULTS: Study I includes 58, and study II 23 patients with parapertussis. In study I, the incidence of parapertussis was 0.016 cases per 100 person years in children 0 to 6 years old and 0 in older children and adults. In study II, the incidence rates of parapertussis and pertussis were 0.2 and 16.2 per 100 person years, respectively, in children followed from 3 months to 3 years of age. The median number of days with cough was 21 in parapertussis and 59 in pertussis. The proportions of children with whooping and vomiting were lower in parapertussis than in pertussis. Geometric mean serum filamentous hemagglutinin IgG increased from 6 to 63, and pertactin IgG from 4 to 12 units/mL in parapertussis patients, which was similar to increases in children with pertussis. CONCLUSIONS: Disease caused by Bordetella parapertussis is diagnosed less commonly and is milder and of shorter duration than disease caused by Bordetella pertussis. Parapertussis induced serum IgG against filamentous hemagglutinin and pertactin of similar magnitude as does pertussis, and did not induce serum IgG against pertussis toxin.  (+info)

Pregenomic comparative analysis between bordetella bronchiseptica RB50 and Bordetella pertussis tohama I in murine models of respiratory tract infection. (6/236)

We describe here a side-by-side comparison of murine respiratory infection by Bordetella pertussis and Bordetella bronchiseptica strains whose genomes are currently being sequenced (Tohama I and RB50, respectively). B. pertussis and B. bronchiseptica are most appropriately classified as subspecies. Their high degree of genotypic and phenotypic relatedness facilitates comparative studies of pathogenesis. RB50 and Tohama I differ in their abilities to grow in the nose, trachea, and lungs of BALB/c mice and to induce apoptosis, lung pathology, and an antibody response. To focus on the interactions between the bacteria and particular aspects of the host immune response, we used mice with specific immune defects. Mice lacking B cells and T cells were highly susceptible to B. bronchiseptica and were killed by intranasal inoculation with doses as low as 500 CFU. These mice were not killed by B. pertussis, even when doses as high as 10(5) CFU were delivered to the lungs. B. bronchiseptica, which was highly resistant to naive serum in vitro, caused bacteremia in these immunodeficient mice, while B. pertussis, which was highly sensitive to naive serum, did not cause bacteremia. B. bronchiseptica was, however, killed by immune serum in vitro, and adoptive transfer of anti-Bordetella antibodies protected SCID-beige mice from B. bronchiseptica lethal infection. Neutropenic mice were similarly killed by B. bronchiseptica but not B. pertussis infection, suggesting neutrophils are critical to the early inflammatory response to the former but not the latter. B. bronchiseptica was dramatically more active than B. pertussis in mediating the lysis of J774 cells in vitro and in inducing apoptosis of inflammatory cells in mouse lungs. This side-by-side comparison describes phenotypic differences that may be correlated with genetic differences in the comparative analysis of the genomes of these two highly related organisms.  (+info)

Polymorphism in the pertussis toxin promoter region affecting the DNA-based diagnosis of Bordetella infection. (7/236)

The pertussis toxin (PT) promoter region is a frequently used target for DNA-based diagnosis of pertussis and parapertussis infections. The reported polymorphism in this region has also allowed discrimination of species in mixtures with several Bordetella species by their specific PCR amplicon restriction patterns. In the present study, we investigated the degree of polymorphism in order to confirm the reliability of the assay. Five different sequence types of the amplified 239- or 249-bp region were found among the 33 Bordetella pertussis, B. parapertussis, and B. bronchiseptica American Type Culture Collection reference strains and patient isolates analyzed. According to the sequences that were obtained and according to the PT promoter sequences already available in the databases, restriction enzyme analysis with TaqI, BglI, and HaeII, which gave four different patterns, can be performed to reliably identify B. pertussis, B. parapertussis, and B. bronchiseptica.  (+info)

Biological activities of lipopolysaccharides extracted from porcine vaccine strains. (8/236)

Lipopolysaccharides (LPSs) were purified from Actinobacillus pleuropneumoniae serotype 2, Bordetella bronchiseptica and Haemophilus parasuis serotype 5, which were used for vaccine production in Japan, by the phenol-water procedure. In SDS-PAGE analysis, A. pleuropneumoniae LPS, as well as Escherichia coli LPS, demonstrated a typical ladder profile of a smooth-type LPS. On the other hand, B. bronchiseptica and H. parasuis LPSs lacked the ladder profiles. It was found that the biological activity of these LPSs was comparable to those of E. coli LPS in terms of activation of the clotting enzyme of Limulus amoebocyte lysate, mitogenic activity of mouse spleen cells, stimulation of TNF-alpha and nitric oxide production, but IL-6 production could hardly be observed in any LPS.  (+info)

Bordetella are small Gram-negative coccobacilli, of which Bordetella pertussis is the most important human pathogen. It is the cause of whooping cough, which is one of the 10 leading causes of childhood death. Transmission of this highly infectious organism is primarily by aerosolized droplets.Clinical features-presentation varies with age, immunization and previous infection: (1) infants-apnoea, cyanosis, and paroxysmal cough; (2) nonimmunized children-cough, increasing in severity with distressing, repeated, forceful expirations followed by a gasping inhalation (the whoop); (3) children immunized in infancy-whooping, vomiting, sputum production; (4) adults-cough, post-tussive vomiting. Atypical mild illness is common. Complications include pneumonia, pulmonary hypertension, seizures and encephalopathy. Most deaths occur in those less than 2 months old....
Rachel M. Stenger, Martien C. M. Poelen, Ed E. Moret, Betsy Kuipers, Sven C. M. Bruijns, Peter Hoogerhout, Marcel Hijnen, Audrey J. King, Frits R. Mooi, Claire J. P. Boog, Cécile A. C. M. van Els ...
Adler K, Radeloff I, Stephan B, Greife H, Helelmann K. Bacteriological and virological status in upper respiratory tract infections of cats. Berl.Munch.Tierarztl.Wochenschr. 2007;120 (3-4):120-125.. Veir JK, Ruch-Gallie R, Spindel ME, Lappin MR. Prevalence of selected infectious organisms and comparisons of two anatomic sampling sites in shelter cats with upper respiratory tract diseases. J.Feline Med. Surg. 2008;10(6):551-557.. Schwarz S, Alesik E, Grobbel M, Lübke-Becker A, Werckenthin C, Wieler LH, et al. Antimicrobial susceptibility of Pasteurella multocida and Bordetella bronchiseptica from dogs and cats as determined in the BfT-GermVet monitoring program 2004-2006. Berl. Munch.Tierarztl.Wochenschr. 2007;120(9-10): 423-430.. Bauwens JE, Spach DH, Schacker TW, Mustafa MM, Bowden RA. Bordetella bronchiseptica pneumonia and bacteremia following bone marrow transplantation. J Clin Microbiol 1992;30: 2474-5.. Binns SH, Dawson S, Speakman AJ, et al. Prevalence and risk factors or feline ...
We describe the epidemiology of a pertussis outbreak in Japan in 2010-2011 and Bordetella holmesii transmission. Six patients were infected; 4 patients were students and a teacher at the same junior high school. Epidemiologic links were found between 5 patients. B. holmesii may have been transmitted from person to person.
Of the 10 identified species in the genus Bordetella, only four are of major medical significance. B. pertussis infects only humans and is the most important Bordetella species causing human disease. B. parapertussis causes an illness in humans that is similar to pertussis but is typically milder; co-infections with B. parapertussis and B. pertussis have been documented. With improved polymerase chain reaction (PCR) diagnostic methodology, up to 20% of patients with a pertussis-like syndrome have been found to be infected with B. holmesii, formerly thought to be an unusual cause of bacteremia. B. bronchiseptica is an important pathogen of domestic animals that causes kennel cough in dogs, atrophic rhinitis and pneumonia in pigs, and pneumonia in cats. Both respiratory infection and opportunistic infection due to B. bronchiseptica are occasionally reported in humans. B. petrii, B. hinzii, and B. ansorpii have been isolated from patients who are immunocompromised. ...
Both virus and bacterial causes of kennel cough are spread through the air by infected dogs sneezing and coughing. It can also spread through contact with contaminated surfaces and through direct contact. It is highly contagious, even days or weeks after symptoms disappear. Symptoms begin usually two to three days after exposure,[2] and can progress to pneumonia. Various studies have shown that kennel cough is a zoonotic disease, meaning it can transfer from animal to human and vice versa. These studies indicate that Bordetella bronchiseptica infections in humans are uncommon and generally occur in immunocompromised individuals ...
We report 2 cases of pulmonary Bordetella hinzii infection in immunodeficient patients. One of these rare cases demonstrated the potential transmission of the bacteria from an avian reservoir through occupational exposure and its persistence in humans. We establish bacteriologic management of these infections and suggest therapeutic options if needed ...
Bordetella parapertussis ATCC ® 15311D-5™ Designation: Genomic DNA from Bordetella parapertussis Strain 522 TypeStrain=True Application:
Bordetella parapertussis: | | | | |Bordetella parapertussis| | | ... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled.
Coloured scanning electron micrograph (SEM) of Bordetella bronchiseptica, Gram-negative, aerobic, motile, coccobacillus prokaryote (bacterium). Bordetella bronchiseptica typically infects the respiratory tracts of smaller mammals (cats, dogs, rabbits). It causes infectious bronchitis, but rarely infects humans. It does not express pertussis toxin, which is one of the characteristic virulence factors of B. pertussis. It is related to Bordetella pertussis, the obligate human pathogen, that causes pertussis or whooping cough. B. bronchiseptica does not express pertussis toxin, which is one of the characteristic virulence factors of B. pertussis. Humans are not natural carriers of B. bronchiseptica. Magnification: x4,400 when shortest axis printed at 25 millimetres. - Stock Image C032/2756
Bordetella bronchiseptica ATCC ® BAA-588D-5™ Designation: Genomic DNA from Bordetella bronchiseptica strain RB50 TypeStrain=False Application:
DEMONSTRATION OF ONE YEAR DURATION-OF-IMMUNITY FOR A FELINE BORDETELLA BRONCHISEPTICA VACCINE. J.R. Williams, R. Laris. OBJECTIVE: The objective of this study was to determine the ability of a modified live intranasal Bordetella bronchiseptica vaccine (Nobivac-Bb) to prevent disease in cats for a period of one year following vaccination. EXPERIMENTAL DESIGN: Forty-eight cats were vaccinated according to manufacturers instructions. Twenty-four vaccinated cats and 12 controls were challenged with a virulent strain of B. bronchiseptica six-months after vaccination, and two additional groups of vaccinates and controls were challenged one year after vaccination. Clinical signs were recorded daily for two weeks after challenge, and clinical scores were calculated for each group. The Mann-Whitney U test was used to determine if clinical scores in the vaccinated groups were significantly different from scores in the control groups. RESULTS: The mean clinical score for vaccinated cats at six-months ...
Looking for Bordetella avium? Find out information about Bordetella avium. A nonsporulating, gram-negative coccobacillus that causes respiratory infections in birds Explanation of Bordetella avium
ICD-10 A37.11 is whooping cough due to bordetella parapertussis with pneumonia (A3711). This code is grouped under diagnosis codes for certain infectious and parasitic diseases.
A37.11 ICD 10 CM Code for Whooping cough due to Bordetella parapertussis with pneumonia, Convert ICD 10 CM code A37.11 to ICD 9 CM code.
1ZBO: X-Ray Crystal Structure of Protein BPP1347 from Bordetella parapertussis. Northeast Structural Genomics Consortium Target BoR27.
Nobivac Feline-Bb is for the intranasal vaccination of healthy kittens and cats for prevention of disease caused by Bordetella bronchiseptica. B. bronchiseptica acts as a primary or secondary pathogen in feline respiratory disease.
Bordetella is a genus of small (0.2 - 0.7 µm), Gram-negative coccobacilli of the phylum Proteobacteria. Bordetella species, with the exception of B. petrii, are obligate aerobes, as well as highly fastidious, or difficult to culture. All species can infect humans. The first three species to be described (B. pertussis, B. parapertussis, B. bronchiseptica,); are sometimes referred to as the classical species. One of these (B. bronchiseptica) is also motile. B. pertussis and occasionally B. parapertussis cause pertussis or whooping cough in humans, and some B. parapertussis strains can colonise sheep. B. bronchiseptica rarely infects healthy humans, though disease in immunocompromised patients has been reported. B. bronchiseptica causes several diseases in other mammals, including kennel cough and atrophic rhinitis in dogs and pigs, respectively. Other members of the genus cause similar diseases in other mammals, and in birds (B. hinzii, B. avium). The Bordetella genus is named after Jules ...
Members of the Bordetella genus alternate between two distinct phenotypic phases in response to changes in their environment. This switch, termed phenotypic modulation, is mediated by the BvgAS sensory transduction system. We developed an animal model based on the interaction of Bordetella bronchiseptica with one of its natural hosts, the rabbit. To investigate the importance of BvgAS signal transduction, we constructed constitutive (RB53) and Bvg- (RB54) phase-locked derivatives of a wild-type strain, RB50. RB50 and RB53, but not RB54, established respiratory infections in B. bronchiseptica-free rabbits with an intranasal 50% infective dose of less than 200 organisms, and the course of the infection closely resembled that observed with naturally infected rabbits. Bacteria were recovered from the nasal cavity, larynx, trachea, and lungs in similar numbers from RB50- and RB53-infected rabbits, yet no pathology was detected by histological examination of lung and tracheal sections. The antibody ...
The genus Bordetella comprises several bacterial species that colonize the respiratory tract of mammals. It includes B. pertussis, a human-restricted pathogen that is the causative agent of Whooping Cough. In contrast, the closely related species B. bronchiseptica colonizes a broad range of animals as well as immunocompromised humans. Recent metagenomic studies have identified known and novel bordetellae isolated from different environmental sources, providing a new perspective on their natural history. Using phylogenetic analysis, we have shown that human and animal pathogenic bordetellae have most likely evolved from ancestors that originated from soil and water. Our recent study found that B. bronchiseptica can evade amoebic predation and utilize Dictyostelium discoideum as an expansion and transmission vector, which suggests that the evolutionary pressure to evade the amoebic predator enabled the rise of bordetellae as respiratory pathogens. Interactions with amoeba may represent the starting point
|EM>Bordetella pertussis|/EM>, |EM>Bordetella parapertussis|/EM> and |EM>Bordetella bronchiseptica|/EM> are closely related Gram-negative Beta-proteobacteria that colonizes the respiratory tracts of mammals. |EM>B. parapertussis|/EM> causes whooping cough in a wide range of animals. D-Alanine is a necessary precursor in the biosynthesis of cell [...]
Humoral immunity is important for protection against viral infection and neutralization of extracellular virus, but clearance of virus from infected tissues is thought to be mediated solely by cellular immunity. However, in a SCID mouse model of persistent alphavirus encephalomyelitis, adoptive transfer of hyperimmune serum resulted in clearance of infectious virus and viral RNA from the nervous system, whereas adoptive transfer of sensitized T lymphocytes had no effect on viral replication. Three monoclonal antibodies to two different epitopes on the E2 envelope glycoprotein mediated viral clearance. Treatment of alphavirus-infected primary cultured rat neurons with these monoclonal antibodies to E2 resulted in decreased viral protein synthesis, followed by gradual termination of mature infectious virion production. Thus, antibody can mediate clearance of alphavirus infection from neurons by restricting viral gene expression. ...
A Gram negative species of bacteria, Campylobacter jejuni, is the leading cause of food poisoning worldwide. Humans often contract food poisoning after ingesting contaminated poultry. Detecting the presence of C. jejuni in poultry is difficult because it is part of the natural flora and does not cause symptomatic infection. In a related manner, Bordetella avium is a Gram negative species of bacteria that causes bordetellosis in poultry. This disease is similar to whooping cough caused by the related pathogen of humans, B. pertussis. Though the mortality rate for bordetellosis is low, it weakens the birds immune systems, often leading to secondary infections. The aim of this project was to construct a vaccine platform capable of immunizing poultry against both pathogens-B. avium and C. jejuni-thus reducing disease in birds and humans. A heterologous construct can be made utilizing the B. avium autotransporter Baa1 that plays a role in host cell attachment. Autotransporters are comprised of three genetic
Free, official coding info for 2018 ICD-10-CM A37.11 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
2KAT: Solution structure of protein BPP2914 from Bordetella parapertussis. Northeast Structural Genomics Consortium target BpR206
ID A0A0H4W4T7_9BORD Unreviewed; 231 AA. AC A0A0H4W4T7; DT 14-OCT-2015, integrated into UniProtKB/TrEMBL. DT 14-OCT-2015, sequence version 1. DT 22-NOV-2017, entry version 16. DE SubName: Full=DnaA regulatory inactivator Hda {ECO:0000313,EMBL:AKQ57115.1}; GN Name=hda {ECO:0000313,EMBL:AKQ57115.1}; GN ORFNames=ACR54_03827 {ECO:0000313,EMBL:AKQ57115.1}; OS Bordetella hinzii. OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Alcaligenaceae; Bordetella. OX NCBI_TaxID=103855 {ECO:0000313,EMBL:AKQ57115.1, ECO:0000313,Proteomes:UP000036382}; RN [1] {ECO:0000313,Proteomes:UP000036382} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=F582 {ECO:0000313,Proteomes:UP000036382}; RA Weigand M.R., Changayil S., Kulasekarapandian Y., Batra D., RA Williams M.M., Tondella M.L.; RT Complete Genome Sequences of Two Bordetella hinzii Isolated from RT Humans.; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the DnaA family. CC ...
Eight collie-cross pups, eight weeks old, were inoculated intramuscularly with an aluminum hydroxide adjuvanted preparation of killed Bordetella bronchiseptica; the inoculation was repeated after two weeks. Two weeks after the second inoculation, the vaccinated dogs and a control group of four unvaccinated animals were placed in contact with a group of five pups of similar age which had been experimentally infected with a pathogenic strain of B bronchiseptica by an aerosol method. All four unvaccinated control dogs as well as all five experimentally infected dogs developed a respiratory disease characterised by persistent coughing. Six of the vaccinated dogs remained free from clinical respiratory disease while disease was less severe and of shorter duration in the remaining two than in controls. Only slight changes were found in the lungs of vaccinated animals at necropsy while in the controls there was a severe tracheobronchitis. There was a marked reduction in the numbers of B bronchiseptica ...
Domain architecture and assignment details (superfamily, family, region, evalue) for gi|187478965|ref|YP_786989.1| from Bordetella avium 197N. Plus protein sequence and external database links.
VetDepot.com - VetDepot is Americas trusted source for discount pet meds from leading brands including Frontline Plus, Dasuquin, Greenies and more. Shop online now.
Your basket is currently empty. i ,p>When browsing through different UniProt proteins, you can use the basket to save them, so that you can back to find or analyse them later.,p>,a href=/help/basket target=_top>More...,/a>,/p> ...
Directly proving aP vaccination puts treated people at risk of acquiring B. parapertussis is very difficult, but we hope our study highlights the need for more thorough B. parapertussis epidemiological data and encourages further work in this neglected area. If our experiments are capturing the phenomenology of what is happening under aP vaccination in humans, it may be important to consider the introduction of vaccines that better protect against both bordetellae; for example, live attenuated B. pertussis nasal vaccines (Mielcarek et al. 2006), wP vaccines containing both B. pertussis and B. parapertussis (Burianova-Vysoka et al. 1970), or supplementation of aP vaccines with B. parapertussis protective antigens (Zhang et al. 2009a). An enhanced understanding of the evolutionary consequences of widespread aP vaccination is needed in order to optimize the next generation of vaccination strategies and fully reap the benefits of this powerful medical intervention ...
Nobivac Feline-Bb prevents diseases caused by Bordetella bronchiseptica. Healthy cats and kittens are protected as early as 72 hours post-vaccination.
The NATtrol BV Negative Control from PubMed Publications delivered next week by Gentaur to your Lab is the best reagent. The catalog number is NATBVNEG-BD and the price is 229 EUR.. ...
Banked acute-phase and convalescent-phase serum samples from a previous study of respiratory illness in university students were examined for significant (≥2-fold) increases in ELISA titers of IgA and IgG antibody to Bordetella pertussis filamentous hemagglutinin, pertactin, and fimbriae-2 and ≥4-fold titer increases to agglutinogens by agglutination. ELISA titers of antibody to pertussis toxin could not be determined because of technical problems. Chlamydia pneumoniae infections were diagnosed by culture or by a ≥4-fold increase in immunofluorescence assay titer or a single high titer (≥512). Mycoplasma pneumoniae, influenza A and B, adenovirus, and respiratory syncytial virus infections were diagnosed by ≥4-fold increases in complement fixation titer or a single high titer (≥64). There were 319 subjects with cough of ≥5 days duration, and of these, 47 (15%) had significant increases in antibody to B. pertussis antigens; 26 (8%) had significant increases to fimbriae-2 or ...
Bordetella pertussis is an aerobic gram-negative bacterial pathogen that causes the human respiratory disease whooping cough. Despite widespread vaccination, whooping cough is reemerging due to decreased vaccine efficacy. One of the hallmarks of infection is lymphocytosis, which is induced by the pertussis toxin. Lymphocytes such as CD4+ T cells navigate to infected tissues through surface-trafficking molecules, which are imprinted during their interaction with tissue-associated dendritic cells. We hypothesized that the pertussis toxin affects the imprinting process resulting in altered expression of trafficking molecules on CD4+ T cells. We tested this hypothesis using a mouse model of infection. Imprinting levels on CD4+ T cells were compared to Bordetella parapertussis, a related strain that lacks pertussis toxin. Our results indicated that 5 days post-infection, the percentage of lung dendritic cells increased and adopted a mature phenotype (displaying an increased capability to migrate and present
BACKGROUND: Each year, Bordetella pertussis infection causes an estimated 294,000 deaths worldwide, primarily among young, nonvaccinated children. Approximately 90% of all deaths due to pertussis in the Unites States occur in young infants. These children often develop intractable pulmonary hypertension; however, the pathophysiologic mechanism responsible for this complication has not been well characterized, and there have been no detailed descriptions of the pathology of this disease since the 1940s.. METHODS: Respiratory tissue samples obtained at autopsy from 15 infants aged ,or=4 months who had polymerase chain reaction- or culture-confirmed B. pertussis pneumonia were evaluated by multiple histochemical stains, immunohistochemical evaluation, and electron microscopic examination.. RESULTS: The pulmonary histopathologic examination of the samples revealed a descending infection dominated by necrotizing bronchiolitis, intra-alveolar hemorrhage, and fibrinous edema. All samples had marked ...
Dr. Burns conducts undergraduate research in the area of microbiology. Students in his lab has performed projects studying interaction of Bordetella bronchiseptica with animal cells, prevalence of Bordetella species in the wild animal population, host specificity of Bordetella bronchiseptica, matrix metalloprotease activation by Group A Streptococcus, coliforms in the Olentangy River Wetlands Research Park, and carriage of Streptococcus pyogenes among Shawnee State University students. Undergraduate students have presented their research at the American Society for Microbiology general meeting, the Ohio Academy of Sciences Annual Meeting, the Beta Beta Beta Biological Honor Society District Convention, and the Celebration of Scholarship Undergraduate Conference, supported by funds from the Department of Natural Sciences, the CAS Deans Office, and the Board of Trustees Award. ...
BLOT kit for the detection of specific IgG antibodies to the recombinant antigens of Bordetella pertussis and Bordetella parapertussis in human serum and plasma, for automated processing using the BlueDiver Instrument.
Replied on 04/19/2011 If she hasnt been vaccinated within the past 6 months she may not be protected as immunity wanes quickly with this particular vaccine. Even if she has been vaccinated recently Bordetella Bronchiseptica is a bacterium that is only part of the complex of pathogens that can cause Kennel Cough . Other components can include Adenovirus, Parainfluenza virus , Mycoplasma and occasionally Herpes virus. The most common cause of Kennel Cough is a combination of Parainfluenza virus and Bordetella Bronchiseptica . We vaccinate against the most common strains of Bordetella and the Parainfluenza virus but there are many variants of Bordetella and we cant vaccinate against them all. The good news is that because she was vaccinated some immunity memory is present and she probably wont get as sick as she would have without the vaccine. Keep her as quiet as possible as exercise worsens the cough. Watch her for lethargy, lack of appetite or a cough that interferes with her sleeping. If ...
Bordetella pertussis and Bordetella parapertussis are the causal agents of whooping cough in humans. They produce diverse virulence factors, including adenylate cyclase-hemolysin (AC-Hly), a secreted toxin of the repeat in toxins (RTX) family with cyclase, pore-forming, and hemolytic activities. Post-translational modifications (PTMs) are essential for the biological activities of the toxin produced by B. pertussis. In this study, we compared AC-Hly toxins from various clinical isolates of B. pertussis and B. parapertussis, focusing on (i) the genomic sequences of cyaA genes, (ii) the PTMs of partially purified AC-Hly, and (iii) the cytotoxic activity of the various AC-Hly toxins. The genes encoding the AC-Hly toxins of B. pertussis and B. parapertussis displayed very limited polymorphism in each species. Most of the sequence differences between the two species were found in the C-terminal part of the protein. Both toxins harbored PTMs, mostly corresponding to palmitoylations of the lysine 860 residue
The Global and Chinese Bordetella Pertussis Industry, 2011-2021 Market Research Report is a professional and in-depth study on the current state of the global Bordetella Pertussis industry with a focus on the Chinese market. The report provides key statistics on the market status of the Bordetella Pertussis manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.. Complete report of 150 pages published in Jan 2016 is available at http://www.market-research-reports.com/434778-bordetella-pertussis-industry.. Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. Then, the report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 2011-2016 market shares for each company. Through the statistical analysis, the report depicts the ...
Bordetella pertussis (whooping cough) - no known animal or environmental reservoir (Mattoo and Cherry 2005 - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082800/ ). Bordetella bronchiseptica, B. parapertussis, and B. holmesii are associated with respiratory infections in humans and other mammals - B. bronchiseptica is a major cause of kennel cough in dogs (Mattoo and Cherry 2005 - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082800/ ). Polio can infect primates: http://jid.oxfordjournals.org/content/175/Supplement_1/S286.full.pdf. Measles: no animal or environmental reservoir is known to exist however Many primate species are susceptible to measles virus infection http://jid.oxfordjournals.org/content/204/suppl_1/S47.full.pdf+html. Cholera: aquatic plants, animals, and sediments (zzoplankton largest known) http://onlinelibrary.wiley.com/doi/10.1111/j.1758-2229.2009.00128.x/abstract. Humans are the only natural reservoir for N. ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time.Find out more ...
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
This vaccine offers effective, safe and effective atrophic rhinitis prevention in baby pigs. Contains avirulent live cultures of avirulent Bordetella bronchiseptica which colonize and block the adherence of disease-causing strains ...
Looking for Bordetella? Find out information about Bordetella. A genus of gram-negative bacteria which are coccobacilli and obligate aerobes, and fail to ferment carbohydrates. These bacteria are respiratory pathogens.... Explanation of Bordetella
ID Q7WA27_BORPA Unreviewed; 245 AA. AC Q7WA27; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 08-MAY-2019, entry version 87. DE SubName: Full=Probable transcriptional regulator {ECO:0000313,EMBL:CAE36865.1}; GN OrderedLocusNames=BPP1563 {ECO:0000313,EMBL:CAE36865.1}; OS Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253). OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Alcaligenaceae; Bordetella. OX NCBI_TaxID=257311 {ECO:0000313,Proteomes:UP000001421}; RN [1] {ECO:0000313,Proteomes:UP000001421} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=12822 / ATCC BAA-587 / NCTC 13253 RC {ECO:0000313,Proteomes:UP000001421}; RX PubMed=12910271; DOI=10.1038/ng1227; RA Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N., RA Harris D.E., Holden M.T., Churcher C.M., Bentley S.D., Mungall K.L., RA Cerdeno-Tarraga A.M., Temple L., James K., Harris B., Quail M.A., RA Achtman M., Atkin R., Baker S., Basham D., ...
ID Q7WA69_BORPA Unreviewed; 120 AA. AC Q7WA69; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 08-MAY-2019, entry version 72. DE SubName: Full=Putative flagellar protein {ECO:0000313,EMBL:CAE36820.1}; GN OrderedLocusNames=BPP1518 {ECO:0000313,EMBL:CAE36820.1}; OS Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253). OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Alcaligenaceae; Bordetella. OX NCBI_TaxID=257311 {ECO:0000313,Proteomes:UP000001421}; RN [1] {ECO:0000313,Proteomes:UP000001421} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=12822 / ATCC BAA-587 / NCTC 13253 RC {ECO:0000313,Proteomes:UP000001421}; RX PubMed=12910271; DOI=10.1038/ng1227; RA Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N., RA Harris D.E., Holden M.T., Churcher C.M., Bentley S.D., Mungall K.L., RA Cerdeno-Tarraga A.M., Temple L., James K., Harris B., Quail M.A., RA Achtman M., Atkin R., Baker S., Basham D., Bason N., ...
Bordetella Vaccines - Bordetella vaccines will ensure your pet doesnt come down with kennel cough. Learn more about bordetella vaccines and treatments.
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
False colour transmission electron micrograph (TEM) of a thin section of the whooping cough bacteria, Bordetella pertussis. The whooping cough bacteria parasitise only humans. They cause a respiratory tract infection characterised by fits of coughing that end in loud inspiratory whoops. The infection is usually contracted in childhood and is potentially fatal in infancy. Adults are sometimes affected. The infection damages the epithelium lining the trachea and bronchi, impairing the beat of the cilia that keep the airways clean. Antibiotics are of very limited effect in treatment. Magnification: X 8800 at 35mm size. - Stock Image B220/0221
We report the repeated isolation of Bordetella petrii in the sputum of a 79-year-old female patient with diffuse bronchiectasis and persistence of the bacterium for >1 year. The patient was first hospitalized due to dyspnea, which developed into seve ...
There was a report out yesterday that the cases of whooping cough (Bordetella pertussis) in Minnesota have doubled from last month and by May, have exceeded all cases reported there last year. There have been 700 cases so far this … Continue reading →. ...
Dynamics of the population structure of Bordetella pertussis as measured by IS1002-associated RFLP: comparison of pre- and post-vaccination strains and global distribution
Biohazard level, growth media and temperature, gram stain, industrial applications and more information for Bordetella pertussis.
When and how often laboratory tests are done may depend on many factors. The timing of laboratory tests may rely on the results or completion of other tests, procedures, or treatments. Lab tests may be performed immediately in an emergency, or tests may be delayed as a condition is treated or monitored. A test may be suggested or become necessary when certain signs or symptoms appear. Due to changes in the way your body naturally functions through the course of a day, lab tests may need to be performed at a certain time of day. If you have prepared for a test by changing your food or fluid intake, lab tests may be timed in accordance with those changes. Timing of tests may be based on increased and decreased levels of medications, drugs or other substances in the body. The age or gender of the person being tested may affect when and how often a lab test is required. Chronic or progressive conditions may need ongoing monitoring through the use of lab tests. Conditions that worsen and improve may ...
Bronchi-Shield Oral 25 Doses, BRONCHI-SHIELD ORAL is a unique Canine Infectious Respiratory Disease (CIRD) vaccine because it is the first live, avirulent Bordetella bronchiseptica vaccine licensed to be administered orally to
CRP is one of the proteins commonly referred to as acute phase reactants. CRP is distinguished by its rapid response to trauma or infection. Increased CRP levels have been found in dogs with arthritis, procitis or thrombophlebitis. Dogs with an increased number of leukocytes had significantly higher CRP levels than dogs with non-inflammatory leukograms. In addition, increased CRP levels have been documented in dogs infected with Ehrlichia canis or Bordetella bronchiseptica. ...
La tos ferina es una enfermedad del tracto respiratorio que se presenta exclusivamente en los seres humanos y es causada por la bacteria gramnegativa Bordetella pertusis.
When it comes to vaccinations, many pet parents want to know exactly what their dog is being protected against. Embrace can help you out.
Bordetella pertussis, Haemophilus influenzae), and some respiratory tract and soft-tissue infections. The antimicrobial ... This is evident, as the treatment dosage is much too low to fight infection, and in DPB cases with the occurrence of the ... Macrolides are actively concentrated within leukocytes, and thus are transported into the site of infection. The macrolide ... They are used to treat respiratory tract infections caused by macrolide-resistant bacteria. Ketolides are especially effective ...
"Avirulence of a Pseudomonas aeruginosa algC mutant in a burned-mouse model of infection". Infection and Immunity. 63 (10): 4166 ... West NP, Jungnitz H, Fitter JT, McArthur JD, Guzmán CA, Walker MJ (August 2000). "Role of phosphoglucomutase of Bordetella ... Pei J, Ficht TA (January 2004). "Brucella abortus rough mutants are cytopathic for macrophages in culture". Infection and ... Infection and Immunity. 73 (10): 6935-44. doi:10.1128/iai.73.10.6935-6944.2005. PMC 1230984. PMID 16177373. Liu XD, Duan J, Guo ...
1991). "Effects of Bordetella pertussis infection on human respiratory epithelium in vivo and in vitro". Infection and Immunity ... 1991-01-01). "Effects of Bordetella pertussis infection on human respiratory epithelium in vivo and in vitro". Infection and ... 2003). "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella ... and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies". Clinical ...
"Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the ... "The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18)". J. ... "Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin". EMBO J. 24 (18): 3190-201 ...
Carbonetti, Nicholas H (2007-06-01). "Immunomodulation in the pathogenesis of Bordetella pertussis infection and disease". ... 2003). "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella ... Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus of the genus Bordetella, and the ... Nieves DJ, Heininger U (2016). "Bordetella pertussis". Bordetella pertussis. Microbiology Spectrum. 4. pp. 311-339. doi:10.1128 ...
Baylisascaris procyonis Bordetella pertussis (Pertussis or whooping cough) Chlamydia pneumoniae Chlamydia trachomatis ( ... A subclinical infection - sometimes called a preinfection or inapparent infection - is an infection that, being subclinical, is ... Subclinical infections are important since they allow infections to spread from a reserve of carriers. They also can cause ... For example, in the case of urinary tract infections in women, this infection may cause preterm delivery if the person becomes ...
Top KA, Halperin SA (2017). 》Pertussis and other Bordetella infections》. Kasper DL, Fauci AS. 》Harrison's Infectious Diseases》 ... Carbonetti NH (June 2007). "Immunomodulation in the pathogenesis of Bordetella pertussis infection and disease". 》Curr Opin ... Carbonetti NH (June 2007). "Immunomodulation in the pathogenesis of Bordetella pertussis infection and disease". 》Current ... 백일해(百日咳; 문화어: 백날기침; 영어: pertussis)는 전염성이 매우 높은 세균병이다.[1][2][3][4] 백일해균(학명: Bordetella pertussis)으로 일어나는 어린이의 호흡기 전염병으로서, 한번 걸리면 ...
... and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies". Clin ... Ebell, MH; Marchello, C; Callahan, M (2017). "Clinical Diagnosis of Bordetella Pertussis Infection: A Systematic Review". J Am ... Carbonetti NH (June 2007). "Immunomodulation in the pathogenesis of Bordetella pertussis infection and disease". Curr Opin ... Top, Karina A.; Halperin, Scott A. (2017). "Pertussis and other Bordetella infections". In Kasper, Dennis L.; Fauci, Anthony S ...
20,0 20,1 ECDC Guidance and protocol for the use of real-time PCR in laboratory diagnosis of human infection with Bordetella ... 21,0 21,1 21,2 ECDC Guidance and protocol for the serological diagnosis of human infection with Bordetella pertussis. 2012 Oct; ... gadā (Bordetella pertussis jeb Bordē-Žangū baktērija).[9] Slimības ierosinātājs ir Bordetella pertussis, nekustīga gramnegatīva ... Clinical manifestations of Bordetella pertussis infection in immunized children and young adults. Chest, 1999 May;115(5):1254-8 ...
... and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies". Clin ... Bordetella is a genus of small (0.2 - 0.7 µm), Gram-negative coccobacilli of the phylum Proteobacteria. Bordetella species, ... Unlike most other Bordetella toxins, tracheal cytotoxin is expressed constitutively, being a normal product of the breakdown of ... Other members of the genus cause similar diseases in other mammals, and in birds (B. hinzii, B. avium). The Bordetella genus is ...
Legionella Infections Chapter 155: Pertussis and Other Bordetella Infections Chapter 156: Diseases Caused by Gram-Negative ... Gonococcal Infections Chapter 152: Haemophilus and Moraxella Infections Chapter 153: Infections Due to the HACEK Group and ... Infections Due to DNA Viruses Chapter 187: Herpes Simplex Virus Infections Chapter 188: Varicella-Zoster Virus Infections ... Health Care-Associated Infections Chapter 137: Infections Acquired in Health Care Facilities Chapter 138: Infections in ...
However, antibodies don't appear until many weeks after infection, maternal antibodies mask the infection of a newborn, and ... Diseases such as pertussis (or whooping cough) are cause by the bacteria Bordetella pertussis. This bacteria is marked by a ... The high sensitivity of PCR permits virus detection soon after infection and even before the onset of disease.[30] Such early ... The earliest tests for infection relied on the presence of antibodies to the virus circulating in the bloodstream. ...
Kidney infection, if it occurs, usually follows a bladder infection but may also result from a blood-borne infection.[12] ... A urinary tract infection (UTI) is an infection that affects part of the urinary tract.[1] When it affects the lower urinary ... Urinary tract infections are the most frequent bacterial infection in women.[17] They occur most frequently between the ages of ... Lower urinary tract infection is also referred to as a bladder infection. The most common symptoms are burning with urination ...
This infection-related cutaneous condition article is a stub. You can help Wikipedia by expanding it.. *v ... Chromobacteriosis infections are a cutaneous condition caused by chromobacteria characterized by fluctuating abscesses.[1]:279 ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Chromobacteriosis_infection&oldid=910443079" ...
In V. cholerae infection, the CPD binds to inositol hexakisphosphate (InsP6, Phytic acid) inside eukaryotic host cells. This ... The C-terminal domain of the adenylate cyclase toxin (ACT or CyaA; TC# 1.C.11.1.4) of Bordetella pertussis forms a small cation ... EHEC-Hly is expressed in numerous EHEC serogroups known to cause severe infections in humans. EHEC-Hly is transported within ... Adenylate cyclase toxin (ACT or CyaA), is a primary virulence factor in Bordetella pertussis. CyaA is a multifunctional RTX ...
The bacterium Bordetella pertussis was first identified as the cause of whooping cough and isolated by Jules Bordet and Octave ... Contaminated food and drinks are the source of infection and how this toxin is spread. Symptoms include abdominal pain as well ... Guiso N. 2009.Bordetella pertussis and pertussis vaccines. Clin. Infect. Dis. 49:1565-1569 Faruque, S. M.; Chowdhury, N; Khan, ... In addition to some of these AB5 toxins being used to create vaccines to prevent bacterial infection, they are also being ...
... opportunistic infections secondary to decreased resistance (often the result of viral infections), or secondary to other ... The most notable of these are Bordetella bronchiseptica, one of the causes of kennel cough, Leptospira sp, which cause ... Infection can spread to humans. There are several fungal diseases that are systemic in nature, meaning they are affecting ... Generalized infections, most commonly seen in immunocompromised dogs, can be treated with oral antifungal drugs such as ...
Bordetella pertussis (Pertussis) is transmitted by cough from human reservoir to susceptible host through direct droplet spread ... The great diversity of infectious pathogens, their possible hosts, and the ways in which their hosts respond to infection has ... Symptomatic persons who are aware of their illness are not as likely to transmit infection because they take precautions to ... In principle, zoonotic diseases can be controlled by isolating or destroying the pathogen's reservoirs of infection. The mass ...
... of people with gonorrheal infection also have chlamydial infection.[54] Infections of the throat can be especially problematic ... Both men and women with infections of the throat may experience a sore throat, though such infection does not produce symptoms ... The infection is usually spread from one person to another through vaginal, oral, or anal sex.[15][22] Men have a 20% risk of ... "Gonococcal Infections - 2015 STD Treatment Guidelines". 4 January 2018.. *^ Ryan, KJ; Ray, CG, eds. (2004). Sherris Medical ...
Since all types of PRRs play a role in the identification and eradication of the infection, their specific agonists mount a ... "Mannose receptor and macrophage galactose-type lectin are involved in Bordetella pertussis mast cell interaction". Journal of ... In a healthy individual Helicobacter pylori infection is targeted by the combination of PRRs, namely TLRs, NLRs, RLRs and CLR ... Burberry A, Zeng MY, Ding L, Wicks I, Inohara N, Morrison SJ, Núñez G (June 2014). "Infection mobilizes hematopoietic stem ...
An increase in lymphocyte concentration is usually a sign of a viral infection (in some rare case, leukemias are found through ... Pertussis toxin (PTx) of Bordetella pertussis, formerly known as lymphocytosis-promoting factor, causes a decrease in the entry ... A low normal to low absolute lymphocyte concentration is associated with increased rates of infection after surgery or trauma. ... This is unique in that many bacterial infections illustrate neutrophil-predominance instead. ...
Bordetella pertussis Plague Yersinia pestis Pneumococcal infection Streptococcus pneumoniae Pneumocystis pneumonia (PCP) ... Human papillomavirus (HPV) infection One of the Human papillomaviruses Human parainfluenza virus infection Human parainfluenza ... Infections associated with diseases. References[edit]. *^ Walsh TJ, Dixon DM (1996). Baron S, et al., eds. Spectrum of Mycoses ... Acinetobacter infections Acinetobacter baumannii Actinomycosis Actinomyces israelii, Actinomyces gerencseriae and ...
Acute bronchitis is normally caused by a viral infection. Typically, these infections are rhinovirus, parainfluenza, or ... A small number of cases are due to high levels of air pollution or bacteria such as Mycoplasma pneumoniae or Bordetella ... The infection may last from a few to ten days.[1] The cough may persist for several weeks afterwards, with the total duration ... In more than 90% of cases, the cause is a viral infection.[4] These viruses may spread through the air when people cough or by ...
Bordetella pertussis. Plague. Yersinia pestis. Pneumococcal infection. Streptococcus pneumoniae. Pneumocystis pneumonia (PCP). ... Helicobacter pylori infection. Helicobacter pylori. Hemolytic-uremic syndrome (HUS). Escherichia coli O157:H7, O111 and O104:H4 ... Clostridium botulinum; Note: Botulism is not an infection by Clostridium botulinum but caused by the intake of botulinum toxin. ...
Lack of response commonly results from clinical factors such as diabetes, steroid use, HIV infection, or age.[citation needed] ... such as Bordetella bronchiseptica, has likely increased in recent years.[104] In some cases, most notably rabies, the parallel ... 19 July 2017 Vaccines promoted as key to stamping out drug-resistant microbes "Immunization can stop resistant infections ... Vaccines can be prophylactic (to prevent or ameliorate the effects of a future infection by a natural or "wild" pathogen), or ...
... skin infections, H. pylori infection, and Lyme disease, among others.[1] Clarithromycin can be taken by mouth as a pill or ... Bordetella pertussis. *Legionella pneumophila. *Pasteurella multocida. Anaerobic Gram-positive bacteria *Clostridium ... It is effective against upper and lower respiratory tract infections, skin and soft tissue infections and helicobacter pylori ... InfectionEdit. A risk of oral candidiasis and vaginal candidiasis, due to the elimination of the yeast's natural bacterial ...
... is a large family of Gram-negative bacteria. It was first proposed by Rahn in 1936, and now includes over 30 genera and more than 100 species. Its classification above the level of family is still a subject of debate, but one classification places it in the order Enterobacterales of the class Gammaproteobacteria in the phylum Proteobacteria.[2][3][4][5] Enterobacteriaceae includes, along with many harmless symbionts, many of the more familiar pathogens, such as Salmonella, Escherichia coli, Klebsiella, and Shigella. Other disease-causing bacteria in this family include Enterobacter and Citrobacter. Members of the Enterobacteriaceae can be trivially referred to as enterobacteria or "enteric bacteria",[6] as several members live in the intestines of animals. In fact, the etymology of the family is enterobacterium with the suffix to designate a family (aceae)-not after the genus Enterobacter (which would be "Enterobacteraceae")-and the type genus is Escherichia. ...
... as well as Bordetella pertussis which causes whooping cough. Other members of the class can infect plants, such as Burkholderia ...
... in genital infections and the increased incidence of the type 2 virus (more common genitally) in oral infections.[citation ... Bordetella pertussis, pneumococci, diphtheria, and rubella.[10] ... the usual route for bacterial infections and those infections ... A vector is an organism that does not cause disease itself but that transmits infection by conveying pathogens from one host to ... Main article: Sexually transmitted infection. This refers to any disease that can be caught during sexual activity with another ...
Blood agar plates are often used to diagnose infection. On the right is a positive Streptococcus culture; on the left is a ... Bordetella *Bordet-Gengou agar. *Enterobacteriaceae *VRBD agar. *Haemophilus influenzae/Legionella pneumophila *Buffered ...
... is an infection of the small intestine by some strains of the bacterium Vibrio cholerae.[3][2] Symptoms may range from ... Infection with V. cholerae O139 should be reported and handled in the same manner as that caused by V. cholerae O1. The ... Cholera - Vibrio cholerae infection-Centers for Disease Control and Prevention. *. "Cholera". Encyclopædia Britannica. 6 (11th ... "Cholera - Vibrio cholerae infection , Cholera , CDC". www.cdc.gov. 2017-05-16. Retrieved 2018-04-04.. ...
Bordetella pertussis, the causative agent of whooping cough, secretes the pertussis toxin partly through the type IV system. ... and the activity of the system is thought to functionally resemble phage infection.[25] ...
Burkholderia pseudomallei (Melioidosis) · Burkholderia mallei (Glanders) · Burkholderia cepacia complex · Bordetella pertussis/ ... Rickettsia aeschlimannii infection) ...
Bordetella pertussis. Whooping cough. DPT vaccine. Boostrix, Adacel, Daptacel, Infanrix, Tripedia, Kinrix, Pediarix, Pentacel, ... Frontiers in Cellular and Infection Microbiology. 2. doi:10.3389/fcimb.2012.00016.. ...
... (TD) is a stomach and intestinal infection. TD is defined as the passage of unformed stool (one or more by ... The primary source of infection is ingestion of fecally contaminated food or water. Attack rates are similar for men and women. ... Antibiotics can also cause vaginal yeast infections, or overgrowth of the bacterium Clostridium difficile, leading to ... Since wilderness campsites seldom provide access to sanitation facilities, the infection risk is similar to that of any ...
Salih, Barik (June 2007). "H pylori infection and other risk factors associated with peptic ulcers in Turkish patients: A ... 2002). "Long-term stress and Helicobacter pylori infection independently induce gastric mucosal lesions in C57BL/6 mice". Scand ... "Monotherapy with mastic does not eradicate Helicobacter pylori infection from mice". J. Antimicrob. Chemother. 51 (2): 367-71 ...
Infections à méningocoques Maladies infectieuses et Africa. West Africa. Med. Bull. 2007[unreliable source?] ... Meningococcal disease describes infections caused by the bacterium Neisseria meningitidis (also termed meningococcus). It has a ... Meningococcal infection is usually introduced into a household by an asymptomatic person. Carriage then spreads through the ... meningitidis infection than complement-satisfactory persons,[27][28][29][30][31][32][33] and it was estimated that the risk of ...
An increase in lymphocyte concentration is usually a sign of a viral infection (in some rare case, leukemias are found through ... Pertussis toxin (PTx) of Bordetella pertussis, formerly known as lymphocytosis-promoting factor, causes a decrease in the entry ... A low normal to low absolute lymphocyte concentration is associated with increased rates of infection after surgery or trauma. ... This is unique in that many bacterial infections illustrate neutrophil-predominance instead. ...
Burkholderia pseudomallei (Melioidosis) · Burkholderia mallei (Glanders) · Burkholderia cepacia complex · Bordetella pertussis/ ... Rickettsia aeschlimannii infection) ...
Trematode infection). Blood fluke. *Schistosoma mansoni / S. japonicum / S. mekongi / S. haematobium / S. intercalatum * ... Tapeworm - Tapeworm infection Cestoda, Taenia multiceps intestine stool rare worldwide Diphyllobothriasis - tapeworm ... Dioctophyme renalis infection Dioctophyme renale kidneys (typically the right) urine rare ingestion of undercooked or raw ... sexually transmitted infection - only trophozoite form (no cysts) Sleeping sickness Trypanosoma brucei brain and blood ...
K. aerogenes is a nosocomial and pathogenic bacterium that causes opportunistic infections including most types of infections. ... Some of the infections caused by K. aerogenes result from specific antibiotic treatments, venous catheter insertions, and/or ...
IgM shows recent infection whereas IgG signifies remote infection. The most important limitation of this test is that it is not ... Typhoid fever, also known simply as typhoid, is a bacterial infection due to Salmonella typhi that causes symptoms.[3] Symptoms ... The typhidot test becomes positive within 2-3 days of infection and separately identifies IgM and IgG antibodies. The test is ... Cholecystectomy is not always successful in eradicating the carrier state because of persisting hepatic infection. ...
The pertussis toxin (also an AB5 protein) produced by Bordetella pertussis acts in a similar manner with the exception that it ... watery diarrhea characteristic of cholera infection.[3] It is a member of the Heat-labile enterotoxin family. ...
Sinus Infection And Allergic Rhinitis. *Specialist Library for ENT and Audiology Hay fever resources - online library of high ... and Bordetella pertussis may help prevent it. ... Rhinitis is commonly caused by a viral or bacterial infection, ... infectious rhinitis includes acute and chronic bacterial infections; (ii) nonallergic (vasomotor) rhinitis includes idiopathic ...
... pylori infection, it does not seem to independently increase risk. Even when coupled with H. pylori infection, the increase is ... In Western countries, the percentage of people with H. pylori infections roughly matches age (i.e., 20% at age 20, 30% at age ... This campaign reinforced the news that ulcers are a curable infection and that health can be greatly improved and money saved ... Overall, H. pylori infections show a worldwide decrease, more so in developed countries. Transmission occurs via food, ...
Bacterial Infections. Impact of Alcaligin Siderophore Utilization on In Vivo Growth of Bordetella pertussis Timothy J. Brickman ... Bacterial Infections. Immunodominance in Mouse and Human CD4+ T-Cell Responses Specific for the Bordetella pertussis Virulence ... Modulation of Pertussis and Adenylate Cyclase Toxins by Sigma Factor RpoE in Bordetella pertussis Mariette Barbier, Dylan T. ... Suppression of T-Lymphocyte Activation and Chemotaxis by the Adenylate Cyclase Toxin of Bordetella pertussis Silvia Rossi ...
... of which Bordetella pertussis is the most important human pathogen. It is the cause of whooping cough, which is one of the 10 ... immunization and previous infection: (1) infants-apnoea, cyanosis, and paroxysmal cough; (2) nonimmunized children-cough, ... Bordetella infection Bordetella infection. Chapter:. Bordetella infection. Author(s):. Cameron Grant. DOI:. 10.1093/med/ ... Description of Bordetella species updated to include Bordetella hinzii, B. trematum, and B. petrii. ...
Immunization with agglutinogen 2 protected mice against infection with 1.2.0 or 1.2.3 serotypes of B. pertussis, whereas ... The ability of purified serospecific agglutinogens from Bordetella pertussis to protect mice against intranasal infection has ... Serospecific protection of mice against intranasal infection with Bordetella pertussis Vaccine. 1989 Aug;7(4):321-4. doi: ... The ability of purified serospecific agglutinogens from Bordetella pertussis to protect mice against intranasal infection has ...
Human infections associated with Bordetella bronchiseptica. Message Subject (Your Name) has forwarded a page to you from ... Human infections associated with Bordetella bronchiseptica.. B F Woolfrey, J A Moody ... When found as a probable pathogen, most infections have been respiratory tract in origin and have occurred in severely ... This study examines the potential of Bordetella bronchiseptica to act as a human pathogen. After encountering two patients from ...
Erythromycin Estolate Chemoprophylaxis for Household Contacts of Children With Culture-Positive Bordetella pertussis Infection ... Comparison of 7 and 14 days of erythromycin estolate treatment of B pertussis infection.23 ... Erythromycin Estolate Chemoprophylaxis for Household Contacts of Children With Culture-Positive Bordetella pertussis Infection ... Erythromycin Estolate Chemoprophylaxis for Household Contacts of Children With Culture-Positive Bordetella pertussis Infection ...
Bordetella avium , trachea, 3 days after infection. Scanning electron microscopy of a trachea from a poult 3 days after ... infection. Note numerous B avium cells attached to ciliated columnar epithelial cells. ...
Vag8, a Bordetella pertussis bvg-Regulated Protein Message Subject (Your Name) has forwarded a page to you from Infection and ... Southern blot analysis indicates that strains ofBordetella bronchiseptica and Bordetella parapertussis have DNA homologous to ... Bordetella pertussis is the causative agent of the disease whooping cough. A two-component regulatory locus, the vir, or bvg, ... Vag8, a Bordetella pertussis bvg-Regulated Protein. Theresa M. Finn, Diana F. Amsbaugh ...
On day 23 of hospitalization, macrolide-resistant Bordetella pertussis was isolated from nasopharyngeal aspirates. DNA ... Co-infection with two different strains of Bordetella pertussis in an infant. J Med Microbiol. 2008;57:388-91. DOIPubMed ... Macrolide-Resistant Bordetella pertussis Infection in Newborn Girl, France. Emerging Infectious Diseases. 2012;18(6):966-968. ... Macrolide-Resistant Bordetella pertussis Infection in Newborn Girl, France On This Page ...
Bordetella Pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective ... Incidence of Bordetella pertussis infection in adolescents and adults. [Clin Infect Dis. 2007] ... Infection rates were determined with a variety of serologic criteria for control and vaccinated subjects. The incidence of ... Asymptomatic infections were approximately 5 times more common than clinical illnesses that met a strict clinical and ...
Comparison of Serological and Real-Time PCR Assays To Diagnose Bordetella pertussis Infection in 2007 Philippe André, Valerie ... Nucleic acid amplification tests for diagnosis of Bordetella infections. J. Clin. Microbiol. 43:4925-4929. ... The incidence of Bordetella pertussis infections estimated in the population from a combination of serological surveys. J. ... Bordetella pertussis and Bordetella parapertussis: two immunologically distinct species. Infect. Immun. 61:486-490. ...
... in the intranasal murine model of infection. To this end B. pertussis Fim2 coding sequence was cloned downstre ... This study examined the immunogenic properties of the fusion protein fimbria 2 of Bordetella pertussis (Fim2)-cholera toxin B ... The data presented here provide support for CTB-Fim2 as a promising recombinant antigen against Bordetella pertussis infection. ... This study examined the immunogenic properties of the fusion protein fimbria 2 of Bordetella pertussis (Fim2)-cholera toxin B ...
Intranasal immunization of adult female Balb/c mice with the Bordetella pertussis antigens FHA or P.69, greatly enhanced their ... Protection of mice against respiratory Bordetella pertussis infection by intranasal immunization with P.69 and FHA Vaccine. ... Intranasal immunization of adult female Balb/c mice with the Bordetella pertussis antigens FHA or P.69, greatly enhanced their ...
... efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis infections in ... efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis infections in ...
Find details on Bordetella bronchiseptica infection in cats including diagnosis and symptoms, pathogenesis, prevention, ... Binns S H, Dawson S, Speakman A J et al (1999) Prevalence and risk factors for feline Bordetella bronchiseptica infection. Vet ... Datz C (2003) Bordetella infections in dogs and cats: treatment and prevention. Compend Contin Educ Pract Vet 25 (12), 902-914 ... Dawson S, Jones D, McCracken C M et al (2000) Bordetella bronchiseptica infection in cats following contact with infected dogs ...
... Ganeshalingham, Anusha ; McSharry, Brent ; Anderson ... Identifying Children at Risk of Malignant Bordetella pertussis Infection.. ResearchSpace/Manakin Repository. Login ...
Pertussis Outbreak in a Primary School in China: Infection and Transmission of the Macrolide-resistant Bordetella pertussis. ... Infection rate was significantly higher in class 2 compared with that in class 1 [37.0% (17/46) vs. 14.6% (7/48), χ2 = 4.26, P ... 0.05]. All Bordetella pertussis isolates were macrolide-resistant, harbored prn1/ptxP1/fim3-1 as previously reported and ...
Bordetella bronchiseptica infections are an important cause for upper tract respiratory disease (URTD) in catteries and rescue ... Bordetella bronchiseptica infection in catteries and rescue shelters. Anyone with experience of cats knows the importance of ... Cat flu is not caused by a single bug but the term describes similar signs caused by infection with one or more different bugs ... Recent research into respiratory diseases of cats has revealed the importance of a new bug: Bordetella bronchiseptica (more ...
An intranasal vaccine is available which can be added to vaccination schedules to help prevent URTD caused by Bordetella ... Since Bordetella bronchiseptica infection in kittens can cause acute death as a result of bronchopneumonia, this risk must be ... Prevention and control of Bordetella bronchiseptica infection in cats. Until now prevention of feline upper respiratory tract ... During parturition, queens may pass Bordetella bronchiseptica to their offspring; kittens obtained from breeding catteries and ...
Guidance and protocol for the use of real-time PCR in laboratory diagnosis of human infection with Bordetella pertussis or ... Guidance and protocol for the use of real-time PCR in laboratory diagnosis of human infection with Bordetella pertussis or ... infection with Bordetella pertussis or B. parapertussis).. Both documents have been produced by the members of the European ... for diagnosis of bordetella infections.. The former document is a consensus document on laboratory guidance for the ...
The infection was successfully managed by antiobiotic therapy. B. bronchiseptica is a pathogen that can cause serious infection ... is a frequent cause of respiratory infections in animals but rarely causes serious infection in humans. We present a rare case ... To our knowledge this is the first case of such an infection in a lung cancer patient undergoing treatment with nivolumab. When ... Human infections associated with bordetella bronchiseptica. Clin Microbiol Rev. 1991;4(3):243-55.View ArticlePubMedPubMed ...
... was recently added to conventional culture and serology for the diagnosis of Bordetella pertussis infection in a large vaccine ... Polymerase chain reaction identification of Bordetella pertussis infections in vaccinees and family members in a pertussis ... was recently added to conventional culture and serology for the diagnosis of Bordetella pertussis infection in a large vaccine ...
Host Genetics of Bordetella pertussis Infection in Mice: Significance of Toll-Like Receptor 4 in Genetic Susceptibility and ... Host Genetics of Bordetella pertussis Infection in Mice: Significance of Toll-Like Receptor 4 in Genetic Susceptibility and ... Home/Host Genetics of Bordetella pertussis Infection in Mice: Significance of Toll-Like Receptor 4 in Genetic Susceptibility ... The susceptibility to and the severity of Bordetella pertussis infections in infants and children varies widely, suggesting ...
Bordetella pertussis was detected by real time RT-PCR in respectively 2/22 (9,1%) and 7/49 (14,3%) cases. In the second season ... Pertussis in children sometimes mimics viral respiratory tract infections. If pertussis diagnostics are based on clinical ... To prevent spreading, physicians should include B. pertussis in routine diagnostics in respiratory tract infections. ... clinical trial evaluating the impact of molecular diagnostics on clinical decision making in pediatric respiratory infections, ...
A murine respiratory infection model was used to study the mechanism of protective immunity to Bordetella pertussis. We found ... Cell mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection ... Cell-mediated immunity to Bordetella pertussis - role of Th1 cells in bacterial clearance in a murine respiratory infection ... role of Th1 cells in bacterial clearance in a murine respiratory infection model? in Infection and Immunity, 61, (2), 1993, pp ...
Respiratory infection with the gram-negative coccobacillus Bordetella pertussis results in whooping cough, a major cause of ... Bordetella Pertussis-specific Serum IgG Responses after Respiratory Infection of Mice with Targeted Gene Disruptions ... Aerosol infection of Ig−/− mice resulted in a persistent chronic lung infection and a failure to clear the bacteria from the ... Bordetella pertussisrespiratory infection in children is associated with preferential activation of type 1 Th cells ...
IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Bordetella Species, DNA. Definition : Molecular assay reagents ... Home > Specialties > IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Bordetella Species, DNA ... Some species of these bacteria may cause infections in the human respiratory tract, including whooping cough. ... intended to identify species of Bordetella, a genus of gram-negative coccobacillus bacteria, by detecting specific genetic ...
Bordetella pertussis infection causing pulmonary hypertension. P Casano, M Pons Odena, F J Cambra, J M Martín, A Palomeque ... Pathology and pathogenesis of fatal Bordetella pertussis infection in infants. Christopher D Paddock, Gary N Sanden, James D ... Successful treatment of ARDS and severe pulmonary hypertension in a child with Bordetella pertussis infection. Daniela Skladal ... Pertussis infection and fatal pulmonary hypertension]. K Menif, A Bouziri, A Khaldi, A Hamdi, S Belhadj, N Benjaballah Archives ...
Fatal Bordetella pertussis infection: report of two cases with novel pathologic findings. R Hackman, D G Perrin, M Karmali, E ... Pathology and pathogenesis of fatal Bordetella pertussis infection in infants. Christopher D Paddock, Gary N Sanden, James D ... BACKGROUND: Each year, Bordetella pertussis infection causes an estimated 294,000 deaths worldwide, primarily among young, ... A controlled study of the relationship between Bordetella pertussis infections and sudden unexpected deaths among German ...
... Edited October 8, 2015. Synopsis. • Bordetella bronchiseptica (Bb) is a primary ... Zoonotic infections have been incidentally recorded in the literature: a possible human infection from a rabbit, infections in ... Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. ... 3. Bordetella bronchiseptica infection can sometimes lead to bronchopneumonia as a complication. Courtesy of Andy Sparkes, UK ...
Top K.A., & Halperin S.A. Top, Karina A., and Scott A. Halperin.Pertussis and Other Bordetella Infections. In: Kasper D, Fauci ... Top K.A., & Halperin S.A. Top, Karina A., and Scott A. Halperin. "Pertussis and Other Bordetella Infections." Harrisons ... Top K.A., & Halperin S.A. Top, Karina A., and Scott A. Halperin. (2014). Pertussis and other bordetella infections. Kasper D, ... Pertussis is an acute infection of the respiratory tract caused by Bordetella pertussis. The name pertussis means "violent ...
  • Southern blot analysis indicates that strains of Bordetella bronchiseptica and Bordetella parapertussis have DNA homologous to vag-8 . (asm.org)
  • The efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis infections in a respiratory mouse model. (rivm.nl)
  • Bordetella pertussis or B. parapertussis). (europa.eu)
  • The guidance and protocol is intended for real-time PCR on DNA extracted from clinical specimens obtained from patients with suspected whooping cough (i.e. infection with Bordetella pertussis or B. parapertussis ). (europa.eu)
  • Of the 9 species of Bordetella ( B. ) identified to date, B. bronchiseptica , B. parapertussis and B. holmesii are associated with respiratory infections in humans and other mammals. (biomedcentral.com)
  • Bordetella pertussis, Bordetella parapertussis and Bb are closely-related Gram-negative coccobacilli that colonise the respiratory tracts of mammals. (abcdcatsvets.org)
  • co-infections with B. parapertussis and B. pertussis have been documented. (mhmedical.com)
  • We and others have recently demonstrated the ability of the three classical Bordetella species ( B. pertussis , B. bronchiseptica , and B. parapertussis ) to form biofilms on abiotic surfaces ( 27 , 45 , 50 ). (asm.org)
  • A comparative analysis of the Bordetella pertussis , B. bronchiseptica , and B. parapertussis genome assemblies permitted the identification of regions with significant sequence divergence and the design of two new real-time PCR assays, BP283 and BP485, for the specific detection of B. pertussis . (asm.org)
  • The B. petrii isolates were compared with other B. petrii isolates collected from humans or the environment and with isolates of B. pertussis, B. parapertussis, B. bronchiseptica, and B. holmesii, obtained from human respiratory tract infections. (cdc.gov)
  • The most thoroughly studied of the Bordetella species are B. bronchiseptica, B. pertussis and B. parapertussis, and the pathogenesis of respiratory disease caused by these bacteria has been reviewed. (wikipedia.org)
  • Bordetella parapertussis infects only sheep and humans, and Bordetella pertussis is an obligate pathogen of humans. (asm.org)
  • Primary infections with either B. pertussis or Bordetella parapertussis stimulated a vigorous antibody response to ACT. (greenmedinfo.com)
  • Prevalence of Bordetella pertussis and Bordetella parapertussis in infants presenting to the emergency department with bronchiolitis. (medscape.com)
  • Bordetella parapertussis and Bordetella holmesii are related pathogens that can also cause pertussislike disease in humans, but the incidence of disease caused by these pathogens is lower than that caused by B. pertussis and these organisms are still relatively poorly understood. (asm.org)
  • This study examines the potential of Bordetella bronchiseptica to act as a human pathogen. (asm.org)
  • When found as a probable pathogen, most infections have been respiratory tract in origin and have occurred in severely compromised hosts. (asm.org)
  • Infection may arise independent of other pathogens as B. bronchiseptica is a primary pathogen. (vetstream.com)
  • B. bronchiseptica is a pathogen that can cause serious infection in humans, especially in immunocompromised or immunoincompetent individuals. (biomedcentral.com)
  • Despite potentially frequent exposure to zoonotic sources of this opportunistic pathogen, human infections are rare. (biomedcentral.com)
  • Bordetella bronchiseptica (Bb) is a primary pathogen of domestic cats, particularly in high population density conditions such as rescue shelters and multicat households. (abcdcatsvets.org)
  • The cell envelope of a bacterial pathogen can be damaged by harsh conditions in the environment outside a host and by immune factors during infection. (biomedcentral.com)
  • Bordetella bronchiseptica is a well-known veterinary pathogen, but its implication in human disease is probably not fully recognized. (cdc.gov)
  • While the human pathogen Bordetella pertussis is the etiological agent of the acute disease whooping cough in infants and young children, it is now being increasingly isolated from the nasopharynges of vaccinated adolescents and adults who sometimes show milder symptoms, such as prolonged cough illness. (asm.org)
  • Bordetella pertussis , the causative agent of pertussis, or whooping cough, is reemerging as a significant respiratory pathogen in many parts of the world ( 2 , 14 , 26 ). (asm.org)
  • Pertussis is a highly contagious respiratory illness caused by the bacterial pathogen Bordetella pertussis . (pnas.org)
  • Infection with Bordetella bronchiseptica ( Bb ), a pathogen involved in canine infectious respiratory disease complex, can be confirmed using culture or qPCR. (biomedcentral.com)
  • Bordetella pertussis , an obligate human pathogen and the agent of whooping cough, is a clonal species, despite the dynamic selection pressures imposed by host immunity and vaccine usage. (asm.org)
  • Bordetella bronchiseptica is another related and more complex pathogen that causes respiratory disease in a number of different animal species, as well as infections in immunocompromised humans. (asm.org)
  • Most cats are exposed to the bacteria Bordetella bronchiseptica before adulthood. (vetstream.com)
  • We found that nude mice, which are deficient in T cells, developed a persistent infection and failed to clear the bacteria after aerosol inoculation. (tcd.ie)
  • In contrast, B cell-deficient mice developed a persistent infection and failed to clear the bacteria after aerosol inoculation. (rupress.org)
  • Molecular assay reagents intended to identify species of Bordetella, a genus of gram-negative coccobacillus bacteria, by detecting specific genetic information of the deoxyribonucleic acid (DNA) of the target bacteria. (ophthalmologymanagement.com)
  • Some species of these bacteria may cause infections in the human respiratory tract, including whooping cough. (ophthalmologymanagement.com)
  • Among the putative Bordetella transcription factors are a number of genes belonging to the extracytoplasmic function (ECF) group of alternative sigma factors, some of which are known to mediate cell envelope stress responses in other bacteria. (biomedcentral.com)
  • Pertussis, commonly known as whooping cough is caused due to a coccobacillus, aerobic, non motile, gram-negative bacteria called Bordetella pertussis. (abilogic.com)
  • One such bacteria is Bordetella bronchisepta , which mainly affects the respiratory tract. (petmd.com)
  • Bacteria belonging to the genus Bordetella cause respiratory tract infections in both humans and animals ( 42 ). (asm.org)
  • Dental or tooth abscess is a collection of pus (infection) caused due to bacteria, which accumulates in the centre (soft pulp) of the tooth. (medical-wiki.com)
  • The initial catarrhal phase of infection produces symptoms similar to those of the common cold, and during this period, large numbers of bacteria can be recovered from the pharynx. (wikipedia.org)
  • Other bacteria recycle this molecule back into the cytoplasm, but in Bordetella and Neisseria gonorrhoeae, it is released into the environment. (wikipedia.org)
  • After infection, the number of bacteria that colonized the respiratory tract of the mice increased during the first day and decreased thereafter. (nih.gov)
  • Specific antibodies to the bacteria were mainly IgG2a and IgA and persisted up to 10 months after infection. (nih.gov)
  • The induction of protective Th1 responses by previous infection with B. pertussis or by immunization with Pw has been associated with IL-12 production by macrophages or dendritic cells (DC), and this has been linked with LPS and active PT present in the live bacteria and residual endotoxin in Pw preparations ( 14 ). (jimmunol.org)
  • A. A bacterial infection caused by the bacteria Bordetella pertussis. (theledger.com)
  • Some of the bacteria which have been cultured from ear infections are Staphylococcus sp, Pseudomonas aeruginosa, Pasteurella multocida, Bordetella bronchiseptica, Proteus mirabilis, Streptoccus epidermidis, Bacteroides spp. (rabbit.org)
  • However, if it is impossible to access the bacteria in order to do the culture, many veterinarians will opt to treat with one of the antibiotics usually successful in curing an inner ear infection, such as enrofloxacin, chloramphenicol or penicillin G procaine with benzathaine. (rabbit.org)
  • Preexisting or simultaneous infections with other respiratory bacteria such as Bordetella bronchiseptica, may influence the ability of P. multocida to colonize and debilitate the tissues (3). (rabbit.org)
  • Ability of the rabbit to resist P. multocida infection depends, in part, on health of the exposed mucosa, and probably on rapid production of mucosal antibodies (IgA) which will inhibit growth of the bacteria. (rabbit.org)
  • Preliminary infection studies with both B. pertussis supernatants and bacteria led to cytoplasmic vacuoles, damaged mitochondria, cellular extrusions, and completely destroyed epithelial cells, which are associated with impaired epithelial barrier integrity (Fig. B). (uni-wuerzburg.de)
  • Upper respiratory infection caused by Bordetella bacteria. (revivalanimal.com)
  • It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. (xenbase.org)
  • Of the 10 identified species in the genus Bordetella , only four are of major medical significance. (mhmedical.com)
  • According to the taxonomical classification, the bacterium B. bronchiseptica belongs to the Proteobacteria phylum, the Alcaligenaceae family and the Bordetella genus [ 7 ]. (biomedcentral.com)
  • Bordetella is a genus of small (0.2 - 0.7 µm), Gram-negative coccobacilli of the phylum Proteobacteria. (wikipedia.org)
  • The Bordetella genus is named after Jules Bordet. (wikipedia.org)
  • The Bordetella genus of respiratory pathogens provides a rich model with which to explore questions of evolution of pathogenesis and host adaptation. (asm.org)
  • The Bordetella genus contains at the moment a dozen species, of which at least five are responsible for respiratory diseases in humans and/or animals. (mdpi.com)
  • The Gross group has a long-standing research experience with B. pertussis and closely related human and animal pathogens belonging to the genus Bordetella [1, 3-5]. (uni-wuerzburg.de)
  • Prosthetic-Joint-Associated Bordetella holmesii Infection. (iu.edu)
  • Recurrent Bordetella holmesii bacteremia and nasal carriage in a patient receiving Rituximab. (thefreelibrary.com)
  • To the Editor: We report a case of recurrent Bordetella holmesii bacteremia with 4 clinical manifestations: 3 episodes of cellulitis and 1 episode of pneumonia. (thefreelibrary.com)
  • B. holmesii isolates were differentiated from other Bordetella spp. (asm.org)
  • However, 2 other Bordetella species, B. bronchiseptica and B. holmesii , behave differently and are able to persist inside their hosts. (cdc.gov)
  • Bordetella holmesii can cause invasive infections but can also be isolated from the respiratory tract of patients with whooping-cough like symptoms. (mdpi.com)
  • Description of Bordetella species updated to include Bordetella hinzii , B. trematum , and B. petrii . (oxfordmedicine.com)
  • B. pertussis infects only humans and is the most important Bordetella species causing human disease. (mhmedical.com)
  • Bordetella species are gram-negative pleomorphic aerobic bacilli that share common genotypic characteristics. (mhmedical.com)
  • B. pertussis is further differentiated from other Bordetella species by biochemical and motility characteristics. (mhmedical.com)
  • Bordetella species are important respiratory pathogens that possess a large number of putative transcription factors. (biomedcentral.com)
  • Despite their importance, no cell envelope stress responses have yet been identified or implicated in pathogenesis in Bordetella species. (biomedcentral.com)
  • Eighteen out of 22 (82%) patients had respiratory symptoms, and the death of 2 patients was associated with respiratory infection.All strains were correctly identified at species level by the simultaneous use of phenotypic methods and were confirmed by specific amplification of the upstream region of the fla gene. (cdc.gov)
  • METHODOLOGY: In conjunction with a large pertussis vaccine efficacy trial in Germany, a central laboratory to isolate Bordetella species from nasopharyngeal specimens was established in Erlangen in October 1990. (unibas.ch)
  • Bordetella species were isolated by use of calcium alginate swabs, Regan-Lowe agar, and modified Stainer-Scholte broth. (unibas.ch)
  • By real-time PCR targeting of IS481, Bordetella DNA was detected in nasopharyngeal swab (NPS) specimens (1), but the species could not be identified because of an insufficient amount of DNA. (thefreelibrary.com)
  • Bordetella species, with the exception of B. petrii, are obligate aerobes, as well as highly fastidious, or difficult to culture. (wikipedia.org)
  • Bordetella bronchiseptica , which has a broad mammalian host range and the most complete set of metabolic pathways of the three species, is thought to be similar to the ancestral form of the group from which the more-host-restricted variants evolved by genome reduction ( 7 , 28 ). (asm.org)
  • Other Bordetella species cause diseases in humans, animals, and birds. (asm.org)
  • This strict aerobe is motile by peritrichous flagella and is capable of growing rapidly at 35 o C to 37 o C Footnote 4 , Footnote 5 and is relatively simple in its nutritional requirements as compared to other Bordetella species Footnote 5 . (canada.ca)
  • Bordetella pertussis, the causative agent of whooping cough, continues to circulate among children and adolescents even in regions with high vaccine coverage. (cdc.gov)
  • Bordetella Pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective randomized Acellular Pertussis Vaccine Trial (APERT). (nih.gov)
  • Relative to control subjects, aP-immunized subjects may have fewer increases in the antibody level (i.e., infections), especially for antibodies to fimbriae 2/3 (an antigen not in the vaccine). (nih.gov)
  • The polymerase chain reaction (PCR) was recently added to conventional culture and serology for the diagnosis of Bordetella pertussis infection in a large vaccine efficacy trial in Germany. (ovid.com)
  • The risk of adverse events from the pertussis vaccine outweighed the risk of pertussis infection. (greenmedinfo.com)
  • Whooping cough commonly affects infants and young children, but immunization with the pertussis vaccine can prevent the infection. (medicinenet.com)
  • Kennel cough, also known as canine infectious tracheobronchitis, is a highly contagious disease that can be prevented with the bordetella vaccine for dogs . (vetinfo.com)
  • The bordetella vaccine is not a core vaccine, which means that it is not a vaccine that is necessary to maintain a healthy dog. (vetinfo.com)
  • The bordetella vaccine is only recommended to your dog if you take him to an area that has a high population of dogs, such as a dog kennel or veterinarian office. (vetinfo.com)
  • These facilities will require the bordetella vaccine. (vetinfo.com)
  • The bordetella vaccine is given to your dog to help decrease the intensity of the disease if he is exposed to kennel cough. (vetinfo.com)
  • There are two different forms of the bordetella vaccine: the injectable form and the intra nasal form. (vetinfo.com)
  • Scientific, clinical, public health, vaccine company, and regulatory agency experts on these pathogens and diseases gathered in Buenos Aires, Argentina from 5 to 8 April 2016 for the 11th International Bordetella Symposium to discuss recent advances in our understanding of the biology of these organisms, the diseases they cause, and the development of new vaccines and other strategies to prevent these diseases. (asm.org)
  • Highlights of the meeting included pertussis epidemiology in developing nations, genomic analysis of Bordetella biology and evolution, regulation of virulence factor expression, new model systems to study Bordetella biology and disease, effects of different vaccines on immune responses, maternal immunization as a strategy to prevent newborn disease, and novel vaccine development for pertussis. (asm.org)
  • Our findings suggest that bordetella infections are common in young adults with cough illnesses (incidence, 9%), and a surprising number of these are mixed infections with other respiratory pathogens. (oup.com)
  • The cell envelope of bacterial pathogens is critical for survival both in a host during infection and in the environment outside of the host. (biomedcentral.com)
  • and selected other respiratory pathogens) and paired blood samples for serologic diagnosis of Bordetella infection. (unibas.ch)
  • Individual hosts and pathogens adapt and respond to each other during the course of an infection, while evolving new offensive and defensive strategies on a population-wide basis. (asm.org)
  • However, cats and dogs still can be a source of human infection by various zoonotic pathogens. (mdpi.com)
  • aP boosters confer protection for adolescents and adults against symptomatic pertussis and likely confer protection against mild and asymptomatic infections, and use of boosters may reduce transmission to others, especially infants. (nih.gov)
  • The susceptibility to and the severity of Bordetella pertussis infections in infants and children varies widely, suggesting that genetic differences between individuals influence the course of infection. (synbiosis.com)
  • Severe pulmonary hypertension associated with shock and death in infants infected with Bordetella pertussis. (qxmd.com)
  • Pathology and pathogenesis of fatal Bordetella pertussis infection in infants. (qxmd.com)
  • A controlled study of the relationship between Bordetella pertussis infections and sudden unexpected deaths among German infants. (qxmd.com)
  • Pertussis is common in nonvaccinated infants hospitalized for respiratory syncytial virus infection. (qxmd.com)
  • Adelaide Research & Scholarship: A marked decrease in L-selectin expression by leucocytes in infants with Bordetella pertussis infection: leucocytosis explained? (edu.au)
  • Young infants are most vulnerable to severe disease and even death when infected with Bordetella pertussis. (clinicaltrials.gov)
  • In addition, in infants younger than 3 months and neonates the increasing incidence of this infection and the sustained mortality rates have encouraged further investigation about the efficacy and safety of pertussis vaccination for pregnant women as an attempt to reduce the disease burden [ 18 ]. (biomedcentral.com)
  • Unimmunized or incompletely immunized young infants are particularly vulnerable to the infection and its complications, which can include pneumonia and seizures . (medicinenet.com)
  • Adults and adolescents are often an important source of infection for infants. (health.gov.au)
  • A wide range of respiratory signs has been associated with Bb infection, from a mild one to severe pneumonia with dyspnoea, cyanosis and death. (abcdcatsvets.org)
  • The Bordetella bronchiseptica organism can cause pneumonia, septicemia, and peritonitis in humans with impaired immune systems. (ekjm.org)
  • Sixty-two human cases of Bordetella bronchiseptica have been published in the English literature, and 84 % hadof the cases were associated with pneumonia or bronchitis. (ekjm.org)
  • In the current study, we report a case of Bordetella bronchiseptica pneumonia diagnosed in an immunocompromised patient. (ekjm.org)
  • In the most severe and rare cases the infection may travel to other parts of the body like the brain (terminating in brain abscess or even meningitis), the lungs (leading to pneumonia) and other such complications. (medical-wiki.com)
  • Because of the numerous infectious etiologies as well as possible co-infections, clinical signs of CIRD-C are highly variable and difficult to predict ranging from mild illness to severe pneumonia or death [ 8 ]. (biomedcentral.com)
  • Complications can include pneumonia and ear infections. (mcgill.ca)
  • Kennel cough weakens your dogs immune system, leaving him more vulnerable to secondary infections such as pneumonia. (vetinfo.com)
  • Mills, K.H.G., Barnard, A.L., Watkins, J. and Redhead, K. `Cell mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model? (tcd.ie)
  • A murine respiratory infection model was used to study the mechanism of protective immunity to Bordetella pertussis. (tcd.ie)
  • Using a murine respiratory challenge model we have previously demonstrated a role for Th1 cells in natural immunity against Bordetella pertussis , but could not rule out a role for antibody. (rupress.org)
  • Additionally, it can lead to a life-threatening infection patients who have an underlying debilitation or impaired immunity. (ekjm.org)
  • In addition to its role during lethal infection of mice deficient in adaptive immunity, our results indicate that SigE is likely to be important for survival in the face of stresses encountered in the environment between hosts. (biomedcentral.com)
  • Engraftment or reconstitution of T-cell-specific immunity is vital to recovery from pulmonary or disseminated infection, regardless of antiviral therapy. (medscape.com)
  • The injectable bordetella offers systemic immunity but does not provide local immunity for the respiratory tract where the infection is occurring. (vetinfo.com)
  • Immunization with agglutinogen 2 protected mice against infection with 1.2.0 or 1.2.3 serotypes of B. pertussis, whereas immunization with agglutinogen 3 protected mice against infection with all serotypes. (nih.gov)
  • More importantly immunization with serospecific agglutinogen resulted in immune selection so that organisms recovered following infection did not express the immunizing antigen. (nih.gov)
  • Immunization with the Recombinant Cholera Toxin B Fused to Fimbria 2 Protein Protects against Bordetella pertussis Infection. (biomedsearch.com)
  • Intranasal immunization of adult female Balb/c mice with the Bordetella pertussis antigens FHA or P.69, greatly enhanced their ability to clear B. pertussis from their lungs following aerosol challenge compared with ovalbumin-immunized controls. (nih.gov)
  • Conclusion: Bordetella infections appear to play a significant rote in AECB and preventive measurements such as immunization with acellular pertussis vaccines should be considered. (unibas.ch)
  • They also provided nasopharyngeal aspirates or, in a few centers, swab samples for culture and/or PCR detection of Bordetella pertussis and an acute blood sample for detection of anti-PT immunoglobulin G (IgG). (asm.org)
  • Since Bordetella bronchiseptica infection in kittens can cause acute death as a result of bronchopneumonia, this risk must be taken seriously. (nobivacbb.com)
  • Therefore, we conducted a study during two winter seasons in pediatric patients presenting with an acute respiratory tract infection (ARI). (biomedcentral.com)
  • Pertussis is an acute infection of the respiratory tract caused by Bordetella pertussis . (mhmedical.com)
  • Banked acute-phase and convalescent-phase serum samples from a previous study of respiratory illness in university students were examined for significant (≥2-fold) increases in ELISA titers of IgA and IgG antibody to Bordetella pertussis filamentous hemagglutinin, pertactin, and fimbriae-2 and ≥4-fold titer increases to agglutinogens by agglutination. (oup.com)
  • One day later, she developed acute kidney injury and was diagnosed with HUS triggered by B. pertussis infection. (biomedcentral.com)
  • Therefore, in patients with HUS secondary to a Bordetella pertussis infection, plasma exchange/infusion (PE/PI) was conducted in most cases during the acute phase because of the possibility of aHUS [ 4 ]. (biomedcentral.com)
  • In this study, we describe an immunocompetent adult with predisposing factors (chronic obstructive respiratory disease and local corticotherapy) who acuired an acute B. petrii infection that had long-lasting persistence. (cdc.gov)
  • The proliferation of Bordetella bronchiseptica-reactive spleen cells occurred during the acute phase of infection. (nih.gov)
  • Genomic analysis of Bordetella petrii isolates chromosomal DNA profiles obtained after digestion with Xba I. Identity of the isolates is indicated. (cdc.gov)
  • Asymptomatic infections were approximately 5 times more common than clinical illnesses that met a strict clinical and microbiologic case definition. (nih.gov)
  • The present prospective cohort study was part of a controlled clinical trial evaluating the impact of molecular diagnostics on clinical decision making in pediatric respiratory infections, performed during 2 winter seasons. (biomedcentral.com)
  • Respiratory (co-) infections may complicate a correct clinical diagnosis of B. pertussis infection. (biomedcentral.com)
  • Considering the heterogenic clinical picture of B. pertussis infections, the diagnosis cannot solely be made on clinical criteria. (biomedcentral.com)
  • Our primary goal was to determine the frequency of B. pertussis cases in the group of unsuspected children in relation to the group of clinically suspected children and to determine clinical predictors of B. pertussis infection in young children. (biomedcentral.com)
  • This prospective cohort study originated in the EVIDENCE-trial (Evaluation of Viral Diagnostics on Respiratory Infections in Children) which was designed as a multicenter, controlled, clinical trial to evaluate the impact of real-time reversed transcriptase polymerase chain reaction (RT-PCR) diagnostics in pediatric patients with ARI. (biomedcentral.com)
  • The clinical presentations of laboratory-confirmed Bordetella pertussis infection in Chang Gung Children's Hospital during 1997 and 2001 were analyzed. (elsevier.com)
  • Infection results in a wide spectrum of clinical manifestations ranging from mild respiratory symptoms to a severe cough illness accompanied by marked leukocytosis and the hallmark inspiratory whoop and posttussive emesis ( 3 ). (pnas.org)
  • Describe the prevalence of Bordetella pertussis via PCR in children under 5 years old hospitalized as probable cases of pertussis and report the most common clinical features among them. (biomedcentral.com)
  • Finally, very little is known so far about the host cell responses on infection which are involved in tissue pathology and clinical disease. (uni-wuerzburg.de)
  • Here we investigate the role of one such gene, sigE, in stress survival and pathogenesis of Bordetella bronchiseptica . (biomedcentral.com)
  • Neurotoxicity from pertussis infection may be casually related to the pathogenesis of Parkinson's disease. (greenmedinfo.com)
  • Much is still unclear about the basic biology of these organisms, the pathogenesis of the diseases they cause, and the most effective strategies to treat and prevent these infections and diseases. (asm.org)
  • The observation that aP, which induces an immune response mismatched to that induced by natural infection, fails to prevent colonization or transmission provides a plausible explanation for the resurgence of pertussis and suggests that optimal control of pertussis will require the development of improved vaccines. (pnas.org)
  • During this same period much was learned about the organism Bordetella pertussis , and this knowledge resulted in the development and present availability of less reactogenic acellular pertussis component diphtheria, tetanus and pertussis vaccines (DTaP vaccines). (aappublications.org)
  • Whole cell pertussis vaccines (Pw) induce Th1 responses and protect against Bordetella pertussis infection, whereas pertussis acellular vaccines (Pa) induce Ab and Th2-biased responses and also protect against severe disease. (jimmunol.org)
  • However, Pw have been associated with a number of local and systemic reactions, and although still used in developing countries, have been replaced in developed countries by acellular pertussis vaccines (Pa), prepared with highly purified Ags from Bordetella pertussis administered with alum as the adjuvant ( 1 , 2 ). (jimmunol.org)
  • The injectable bordetella in a series of two vaccines, given 2 to 4 weeks apart then given annually. (vetinfo.com)
  • Thus, the improvement of the current vaccines is mandatory requiring basic research on Bordetella pathogenicity mechanisms. (uni-wuerzburg.de)
  • The ability of purified serospecific agglutinogens from Bordetella pertussis to protect mice against intranasal infection has been examined. (nih.gov)
  • This study examined the immunogenic properties of the fusion protein fimbria 2 of Bordetella pertussis (Fim2)-cholera toxin B subunit (CTB) in the intranasal murine model of infection. (biomedsearch.com)
  • We therefore screened 11 inbred strains of mice for susceptibility to a pertussis infection after intranasal infection. (synbiosis.com)
  • Intranasal inoculation of Bordetella bronchiseptica in mice induces long-lasting antibody and T-cell mediated immune responses. (nih.gov)
  • The data presented here provide support for CTB-Fim2 as a promising recombinant antigen against Bordetella pertussis infection. (biomedsearch.com)
  • We have used recombinant congenic mouse strains (RCS) as a tool to facilitate the mapping of low-penetrance quantitative trait loci that control complex traits such as a B. pertussis infection [ 7 ]. (beds.ac.uk)
  • Patients and Methods: Patients with AECB, who presented to participating private practices in Basel, Switzerland, between October 2000 and June 2002, were evaluated by a standardized questionnaire, nasopharyngeal swabs for culture (Bordetella spp. (unibas.ch)
  • Infection was followed by quantifying colonization in nasopharyngeal washes and monitoring leukocytosis and symptoms. (pnas.org)
  • Evidence suggests that B. bronchiseptica may be rarely encountered as a commensal or colonizer of the respiratory tract of humans and rarely in association with infection. (asm.org)
  • Bordetella bronchiseptica ( B.bronchiseptica ) is a frequent cause of respiratory infections in animals but rarely causes serious infection in humans. (biomedcentral.com)
  • Being the least host-restricted member of this taxonomic cluster, Bb causes chronic respiratory infections in cats, dogs, rabbits, pigs and humans. (abcdcatsvets.org)
  • Zoonotic infections have been incidentally recorded in the literature: a possible human infection from a rabbit, infections in paediatric lung transplant recipients, where dogs had been suspected as the origin of infection, and cases in immune compromised humans were cats were suspected as source of the infection (Gueirard et al. (abcdcatsvets.org)
  • Both respiratory infection and opportunistic infection due to B. bronchiseptica are occasionally reported in humans. (mhmedical.com)
  • B. avium and B. hinzii caused respiratory infections in birds and poultry and have also been reported to cause infections in humans ( 6 - 9 ). (cdc.gov)
  • It has been implicated as an infrequent cause of infection in humans, primarily in immunocompromised patients exposed to infected animals, although infections have also been reported in immunocompetent individuals as well Footnote 2 , Footnote 5 , Footnote 6 . (canada.ca)
  • B. bronchiseptica infection can be transmitted to humans from infected animals by aerosols carrying the infectious agent Footnote 6 , Footnote 9 , Footnote 10 . (canada.ca)
  • All Bordetella pertussis isolates were macrolide-resistant, harbored prn1/ptxP1/fim3-1 as previously reported and belonged to multilocus variable tandem repeat analysis type MLVA 195. (ovid.com)
  • Pertactin-deficient Bordetella pertussis isolates: evidence of increased circulation in Europe, 1998 to 2015. (greenmedinfo.com)
  • TNF-α expression in the lungs 3 days after infection was increased fivefold compared to uninfected controls in A/J mice and was not affected in C3H/HeJ mice. (synbiosis.com)
  • In conclusion, Tlr4 is a major host factor explaining the differences in the course of infection between these inbred strains of mice. (synbiosis.com)
  • In contrast, normal adult nonimmune mice cleared a respiratory infection approximately 35 days after challenge. (tcd.ie)
  • In contrast, injection of serum from convalescent mice before challenge only marginally reduced the bacterial load early in the course of infection. (tcd.ie)
  • Here we have demonstrated that B. pertussis respiratory infection of mice with targeted disruptions of the genes for the IFN-γ receptor resulted in an atypical disseminated disease which was lethal in a proportion of animals, and was characterized by pyogranulomatous inflammation and postnecrotic scarring in the livers, mesenteric lymph nodes and kidneys. (rupress.org)
  • An examination of the course of infection in the lung of IFN-γ receptor-deficient, IL-4-deficient and wild-type mice demonstrated that lack of functional IFN-γ or IL-4, cytokines that are considered to play major roles in regulating the development of Th1 and Th2 cells, respectively, did not affect the kinetics of bacterial elimination from the lung. (rupress.org)
  • Using a series of immunocompromised mice deficient in different components of the innate and adaptive immune responses, we show that SigE plays an important role in evading the innate immune response during lethal infections of mice lacking B cells and T cells. (biomedcentral.com)
  • Our results showed that bacterial infection was completely abrogated in treated mice when the LPS of B. pertussis (1 g) was added before (48 h or 24 h), after (24 h), or simultaneously with the B. pertussis challenge (107 CFU). (conicet.gov.ar)
  • HcB-28 mice are more resistant to B. pertussis infection than C3H mice, which could partially be ascribed to the B . pertussis susceptibility locus-1 ( Bps1 ) on chromosome 12. (beds.ac.uk)
  • B. bronchiseptica is capable of establishing a chronic and asymptomatic infection and can be harvested from the nasal cavities of rats and mice for extended periods ( 1 , 37 ). (asm.org)
  • Humoral and cellular immune responses were analysed in mice inoculated intranasally with Bordetella bronchiseptica. (nih.gov)
  • T cells from infected mice produced increasing amounts of IFN gamma and IL-2 after infection. (nih.gov)
  • IFN-γ or IFN-γ receptor-defective mice and mice depleted of NK cells, which infiltrate the lung and secrete IFN-γ early in infection, develop disseminating lethal infections ( 11 , 12 , 13 ). (jimmunol.org)
  • Due to the use of at least partially inappropriate animal models (mainly mice) and cell culture model systems which do not resemble the natural situation, i.e. the ciliated and mucus-producing epithelium of the human respiratory tract, the real relevance of known virulence factors of B. pertussis for infection and disease still remains largely speculative. (uni-wuerzburg.de)
  • As part of this project ECDC is publishing two complementary guidance and protocols on Bordetella pertussis , the first on serological diagnosis of human infection and the second on the use of RT-PCR (real time polymerase chain reaction) for diagnosis of bordetella infections. (europa.eu)
  • The diagnosis of B. bronchiseptica infection can be confirmed either by culture or by specific quantitative polymerase chain reaction (qPCR) on various samples including bronchoalveolar lavage fluid (BALF). (biomedcentral.com)
  • To achieve disease control and reduce the risk of infection to the very young, we established a short-term pertussis clinic for the diagnosis and management of cases and their household contacts. (cancerscreening.gov.au)
  • Vaccination with wP and previous infection induced a more rapid clearance compared with naïve and aP-vaccinated animals. (pnas.org)
  • While all groups possessed robust antibody responses, key differences in T-cell memory suggest that aP vaccination induces a suboptimal immune response that is unable to prevent infection. (pnas.org)
  • Environmental and nutritional factors modulate children's response to pertussis following natural infection or by vaccination. (greenmedinfo.com)
  • Seroepidemiologic studies, which measure serum antibody levels produced in response to infection and/or vaccination, can be valuable tools for gaining insight into population level dynamics of infectious diseases. (springer.com)
  • The survey was used to distinguish between antibodies induced by vaccination and pertussis infection. (springer.com)
  • Locht C , Mielcarek N . New pertussis vaccination approaches: en route to protect newborns? (eurosurveillance.org)
  • Risk factors for infection include rescue shelters, multi-cat households, living in unhygienic conditions and contact with dogs with respiratory disease. (vetstream.com)
  • As with feline calicivirus (FCV) and feline herpesvirus (FHV), overcrowding and poor management predispose to infection and disease. (abcdcatsvets.org)
  • Bordetella bronchiseptica is a common cause of respiratory disease in animals but is a rare cause of human infection. (ekjm.org)
  • Generally, TMA syndromes are extraordinarily diverse and may include thrombocytopenic purpura, Shiga toxin-mediated hemolytic uremic syndrome (HUS), complement-mediated HUS (also known as atypical HUS [aHUS]), and other manifestations secondary to an infection, drug, or underlying disease. (biomedcentral.com)
  • However, some unvaccinated, untreated rabbits exposed to P. multocida resist infection altogether and of those with infection a significant number resist disease. (rabbit.org)
  • 6. Chronic infection and disease can occur in areas of the body inaccessible to culture. (rabbit.org)
  • 9. Rabbits with disease due to P. multocida infection should be treated with appropriate antibiotics. (rabbit.org)
  • Before bacterial clearance, antipertussis antibody levels in serum were low or undetectable, whereas consistent antigen-specific T-cell responses were demonstrated throughout the course of infection. (tcd.ie)
  • Bordetella bronchiseptica has a broad host range and naturally infects a wide variety of nonhuman animals. (asm.org)
  • Although it has been shown that Bordetella can form biofilms in vitro, nothing is known about its biofilm mode of existence in mammalian hosts. (asm.org)
  • This observation could be due to the fact that Bordetella bronchiseptica may persist intracellularly in the host as it was demonstrated in vitro. (nih.gov)
  • Chronic infections are easily established by colonization of the ciliated epithelium. (vetstream.com)
  • Integrin-mediated localization of Bordetella pertussis within macrophages: role in pulmonary colonization. (qxmd.com)
  • We recently demonstrated that the enhancement of innate response activation can effi- ciently impair Bordetella pertussis colonization in a Toll-like receptor 4 (TLR4)-dependent manner. (conicet.gov.ar)
  • Baboons vaccinated with aP were protected from severe pertussis-associated symptoms but not from colonization, did not clear the infection faster than naïve animals, and readily transmitted B. pertussis to unvaccinated contacts. (pnas.org)
  • P. multocida is often endemic in rabbit colonies and the acquisition of infection in young rabbits is correlated to the prevalence in adult rabbits (1). (rabbit.org)
  • Unlike most other Bordetella toxins, tracheal cytotoxin is expressed constitutively, being a normal product of the breakdown of the bacterial cell wall. (wikipedia.org)
  • Tracheal cytotoxin (TCT) is a 921 dalton glycopeptide released by Bordetella pertussis and Neisseria gonorrhoeae. (wikipedia.org)
  • A person infected with pertussis is highly contagious (can spread the infection to others) from the onset of symptoms to around three weeks after the onset of the coughing episodes. (medicinenet.com)
  • Bordetella 는 Proteobacteria 문에 속하는 균주로서 그람 음성의 짧은 막대균 형태를 보인다. (ekjm.org)
  • Maternal acquired pertussis-specific antibodies show low concentrations with short persistence in newborns creating a susceptibility gap for infection between birth and the first vaccinations. (clinicaltrials.gov)
  • Elevated antibodies suggestive of recent infection were found among two adults. (springer.com)
  • Some of these specific antibodies were directed against adenylate cyclase-haemolysin, the bacterial factor that had been shown to be necessary for initiation of infection. (nih.gov)
  • High levels of humoral antibodies (IgG) are not associated with elimination of infection but rather with chronic infection (3, 11). (rabbit.org)
  • Thus measurement of P. multocida IgG antibodies in serum is helpful in detecting infections inaccessible to culture in the live rabbit. (rabbit.org)
  • To our knowledge this is the first case of such an infection in a lung cancer patient undergoing treatment with nivolumab. (biomedcentral.com)
  • The exacerbated induction of innate immune responses in airways can abrogate diverse lung infections by a phenomenon known as stimulated innate resistance (StIR). (conicet.gov.ar)
  • Studies about the canine lung microbiota (LM) are recent, sparse, and only one paper has been published in canine lung infection. (biomedcentral.com)
  • Bb infection induced lung dysbiosis, characterized by high bacterial load, low richness and diversity and increased abundance of Bb , compared with healthy dogs. (biomedcentral.com)
  • Serology revealed Bordetella infection in eight (31 patients with Bordetella infection compared to those without Bordetello infection (mean 15 days vs 41 days, p = 0.04). (unibas.ch)
  • 7. Hidden infections sometimes may be detected by radiology, or serology. (rabbit.org)
  • 26 (8%) had significant increases to fimbriae-2 or agglutinogens, indicative of B. pertussis infection, and 2 (1%) had evidence of non- B. pertussis bordetella infections. (oup.com)
  • Strains of Bordetella were grown on Bordet-Gengou (BG) medium supplemented with 12% sheep blood or in cyclodextrin solid medium (CSM) ( 1 ). (asm.org)
  • To further elucidate the role of host genetic factors, in particular in the Bps1 locus, in B. pertussis infection, and to identify candidate genes within in this region, we compared expression profiles in the lungs of the C3H and HcB-28 mouse strains following B. pertussis inoculation. (beds.ac.uk)
  • Two hundred and six genes were differentially expressed between the two mouse strains, but, remarkably, none of these were up- or down-regulated upon B. pertussis infection. (beds.ac.uk)
  • Gene expression changes upon B. pertussis infection are highly identical between the two mouse strains despite the differences in the course of B. pertussis infection. (beds.ac.uk)
  • Because the genes that were differentially regulated between the mouse strains only showed differences in expression before infection, it appears likely that such intrinsic differences in gene regulation are involved in determining differences in susceptibility to B. pertussis infection. (beds.ac.uk)
  • After encountering two patients from whom B. bronchiseptica was isolated, we searched the literature and found 23 reports in which a human infection was reported in association with B. bronchiseptica. (asm.org)
  • The incidence of prolonged cough illness was ascertained for subjects with and subjects without serologic evidence of infection. (nih.gov)
  • Incidence of Bordetella pertussis infection in adolescents and adults. (nih.gov)
  • After experimental infection, the organism has been isolated for 19 weeks. (abcdcatsvets.org)
  • All subjects were observed for almost 2 years for cough illnesses, and all underwent microbiologic and serologic studies for detection of pertussis infection. (nih.gov)
  • Journal Article] Detection of genes expressed in Bordetella bronchiseptica colonizing rat trachea by in vivo expressed-tag immunoprecipitation method. (nii.ac.jp)
  • Cough suppressants are given to reduce cough and antibiotics are used to treat any bacterial infections. (vetinfo.com)
  • Occasionally rabbits harbor chronic infections of internal tissues or organs, such as middle ears or lungs, without any signs of rhinitis and are negative for P. multocida by nasal culture (3). (rabbit.org)