A genus of gram-negative, aerobic bacteria whose cells are minute coccobacilli. It consists of both parasitic and pathogenic species.
A species of gram-negative, aerobic bacteria that is the causative agent of WHOOPING COUGH. Its cells are minute coccobacilli that are surrounded by a slime sheath.
A species of BORDETELLA that is parasitic and pathogenic. It is found in the respiratory tract of domestic and wild mammalian animals and can be transmitted from animals to man. It is a common cause of bronchopneumonia in lower animals.
Infections with bacteria of the genus BORDETELLA.
A species of BORDETELLA with similar morphology to BORDETELLA PERTUSSIS, but growth is more rapid. It is found only in the RESPIRATORY TRACT of humans.
A set of BACTERIAL ADHESINS and TOXINS, BIOLOGICAL produced by BORDETELLA organisms that determine the pathogenesis of BORDETELLA INFECTIONS, such as WHOOPING COUGH. They include filamentous hemagglutinin; FIMBRIAE PROTEINS; pertactin; PERTUSSIS TOXIN; ADENYLATE CYCLASE TOXIN; dermonecrotic toxin; tracheal cytotoxin; Bordetella LIPOPOLYSACCHARIDES; and tracheal colonization factor.
A species of BORDETELLA isolated from the respiratory tracts of TURKEYS and other BIRDS. It causes a highly contagious bordetellosis.
A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)
Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.
One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLYL CYCLASES and hemolysin components.
One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.
A chronic inflammation in which the NASAL MUCOSA gradually changes from a functional to a non-functional lining without mucociliary clearance. It is often accompanied by degradation of the bony TURBINATES, and the foul-smelling mucus which forms a greenish crust (ozena).
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Proteins isolated from the outer membrane of Gram-negative bacteria.
Proteins found in any species of bacterium.
Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.
An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC 4.6.1.1.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
The top portion of the pharynx situated posterior to the nose and superior to the SOFT PALATE. The nasopharynx is the posterior extension of the nasal cavities and has a respiratory function.
Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)
Vaccines that are produced by using only the antigenic part of the disease causing organism. They often require a "booster" every few years to maintain their effectiveness.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Substances, usually of biological origin, that cause cells or other organic particles to aggregate and stick to each other. They include those ANTIBODIES which cause aggregation or agglutination of particulate or insoluble ANTIGENS.
A transient increase in the number of leukocytes in a body fluid.
The functional hereditary units of BACTERIA.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Substances elaborated by bacteria that have antigenic activity.
The scroll-like bony plates with curved margins on the lateral wall of the NASAL CAVITY. Turbinates, also called nasal concha, increase the surface area of nasal cavity thus providing a mechanism for rapid warming and humidification of air as it passes to the lung.
Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.
Specific substances elaborated by plants, microorganisms or animals that cause damage to the skin; they may be proteins or other specific factors or substances; constituents of spider, jellyfish or other venoms cause dermonecrosis and certain bacteria synthesize dermolytic agents.
The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
Preparations of pathogenic organisms or their derivatives made nontoxic and intended for active immunologic prophylaxis. They include deactivated toxins. Anatoxin toxoids are distinct from anatoxins that are TROPANES found in CYANOBACTERIA.
Large woodland game BIRDS in the subfamily Meleagridinae, family Phasianidae, order GALLIFORMES. Formerly they were considered a distinct family, Melegrididae.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Excess of normal lymphocytes in the blood or in any effusion.
The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)
A vaccine consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and whole-cell PERTUSSIS VACCINE. The vaccine protects against diphtheria, tetanus, and whooping cough.
Thin, hairlike appendages, 1 to 20 microns in length and often occurring in large numbers, present on the cells of gram-negative bacteria, particularly Enterobacteriaceae and Neisseria. Unlike flagella, they do not possess motility, but being protein (pilin) in nature, they possess antigenic and hemagglutinating properties. They are of medical importance because some fimbriae mediate the attachment of bacteria to cells via adhesins (ADHESINS, BACTERIAL). Bacterial fimbriae refer to common pili, to be distinguished from the preferred use of "pili", which is confined to sex pili (PILI, SEX).
The proximal portion of the respiratory passages on either side of the NASAL SEPTUM. Nasal cavities, extending from the nares to the NASOPHARYNX, are lined with ciliated NASAL MUCOSA.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Diseases of domestic swine and of the wild boar of the genus Sus.
Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.
The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).
Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria normally found in the flora of the mouth and respiratory tract of animals and birds. It causes shipping fever (see PASTEURELLOSIS, PNEUMONIC); HEMORRHAGIC BACTEREMIA; and intestinal disease in animals. In humans, disease usually arises from a wound infection following a bite or scratch from domesticated animals.
Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
An iron-binding cyclic trimer of 2,3-dihydroxy-N-benzoyl-L-serine. It is produced by E COLI and other enteric bacteria.
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.

Role of antibodies against Bordetella pertussis virulence factors in adherence of Bordetella pertussis and Bordetella parapertussis to human bronchial epithelial cells. (1/308)

Immunization with whole-cell pertussis vaccines (WCV) containing heat-killed Bordetella pertussis cells and with acellular vaccines containing genetically or chemically detoxified pertussis toxin (PT) in combination with filamentous hemagglutinin (FHA), pertactin (Prn), or fimbriae confers protection in humans and animals against B. pertussis infection. In an earlier study we demonstrated that FHA is involved in the adherence of these bacteria to human bronchial epithelial cells. In the present study we investigated whether mouse antibodies directed against B. pertussis FHA, PTg, Prn, and fimbriae, or against two other surface molecules, lipopolysaccharide (LPS) and the 40-kDa outer membrane porin protein (OMP), that are not involved in bacterial adherence, were able to block adherence of B. pertussis and B. parapertussis to human bronchial epithelial cells. All antibodies studied inhibited the adherence of B. pertussis to these epithelial cells and were equally effective in this respect. Only antibodies against LPS and 40-kDa OMP affected the adherence of B. parapertussis to epithelial cells. We conclude that antibodies which recognize surface structures on B. pertussis or on B. parapertussis can inhibit adherence of the bacteria to bronchial epithelial cells, irrespective whether these structures play a role in adherence of the bacteria to these cells.  (+info)

The detection of DNA from a range of bacterial species in the joints of patients with a variety of arthritides using a nested, broad-range polymerase chain reaction. (2/308)

OBJECTIVE: Bacteria have been implicated in the pathogenesis of many types of inflammatory arthritides. The aim of this study was to identify any bacterial DNA in synovial fluid (SF) from patients with a range of inflammatory arthritides. METHODS: A highly sensitive, broad-range, nested polymerase chain reaction (PCR) protocol targeting the bacterial 16S rRNA gene was designed and applied to SF from 65 patients with a range of rheumatic diseases. RESULTS: Bacterial DNA was detected in 26 SF samples, including eight from patients with rheumatoid arthritis and five with juvenile arthritides. PCR products were identified by sequencing and searching of bacterial genomic databases; 'best fits' included Haemophilus influenzae, Bordetella and Yersinia. CONCLUSIONS: These finding suggest an association between bacterial infection and inflammatory arthritides in some patients. Further research is required to determine the role of these organisms in the pathogenesis and whether such patients might respond to prolonged antibiotic therapy.  (+info)

Genetic characterization of wild-type and mutant fur genes of Bordetella avium. (3/308)

For most, if not all, organisms, iron (Fe) is an essential element. In response to the nutritional requirement for Fe, bacteria evolved complex systems to acquire the element from the environment. The genes encoding these systems are often coordinately regulated in response to the Fe concentration. Recent investigations revealed that Bordetella avium, a respiratory pathogen of birds, expressed a number of Fe-regulated genes (T. D. Connell, A. Dickenson, A. J. Martone, K. T. Militello, M. J. Filiatraut, M. L. Hayman, and J. Pitula, Infect. Immun. 66:3597-3605, 1998). By using manganese selection on an engineered strain of B. avium that carried an Fe-regulated alkaline phosphatase reporter gene, a mutant was obtained that was affected in expression of Fe-regulated genes. To determine if Fe-dependent regulation in B. avium was mediated by a fur-like gene, a fragment of the B. avium chromosome, corresponding to the fur locus of B. pertussis, was cloned by PCR. Sequencing revealed that the fragment from B. avium encoded a polypeptide with 92% identity to the Fur protein of B. pertussis. In vivo experiments showed that the cloned gene complemented H1780, a fur mutant of Escherichia coli. Southern hybridizations and PCRs demonstrated that the manganese mutant had a deletion of 2 to 3 kbp of nucleotide sequence in the region located immediately 5' of the fur open reading frame. A spontaneous PCR-derived mutant of the B. avium fur gene was isolated that encoded a Fur protein in which a histidine was substituted for an arginine at amino acid position 18 (R18H). Genetic analysis showed that the R18H mutant gene when cloned into a low-copy-number vector did not complement the fur mutation in H1780. However, the R18H mutant gene was able to complement the fur mutation when cloned into a high-copy-number vector. The cloned wild-type fur gene will be useful as a genetic tool to identify Fur-regulated genes in the B. avium chromosome.  (+info)

Bordetella holmesii-like organisms isolated from Massachusetts patients with pertussis-like symptoms. (4/308)

We isolated Bordetella holmesii, generally associated with septicemia in patients with underlying conditions, from nasopharyngeal specimens of otherwise healthy young persons with a cough. The proportion of B. holmesii-positive specimens submitted to the Massachusetts State Laboratory Institute increased from 1995 to 1998.  (+info)

Identification of functional domains of Bordetella dermonecrotizing toxin. (5/308)

Bordetella dermonecrotizing toxin (DNT) stimulates the assembly of actin stress fibers and focal adhesions by deamidating Gln63 of the small GTPase Rho. To clarify the functional and structural organization of DNT, we cloned and sequenced the DNT gene and examined the functions of various DNT mutants. Our analyses of the nucleotide and amino acid sequences revealed that the start codon of the DNT gene is a GTG triplet located 39 bp upstream of the reported putative initiation ATG codon; consequently, DNT contains an additional 13 amino acids at its N-terminal end. All of the N-terminally truncated mutants were found to modify Rho. The shortest fragment of DNT possessing the Rho modification activity consists of amino acids from Ile1176 to the C-terminal end. This fragment overlaps the region homologous to Escherichia coli cytotoxic necrotizing factors (CNFs), which show activity similar to that of DNT. The introduction of a mutation at Cys1305 located in the highly conserved region between CNFs and DNT eliminated the activity, indicating that this domain is the catalytic center of DNT. The N-terminal fragment (1 to 531) of DNT failed to modify Rho but reduced the DNT-induced polynucleation in MC3T3-E1 cells when simultaneously added with the holotoxin, suggesting competitive inhibition in the receptor-binding or internalizing step. Our finding that DNT consists of an N-terminal receptor-binding and/or internalizing domain and a C-terminal catalytically active domain may facilitate analysis of the overall action of the toxin on the mammalian target cells.  (+info)

Genetic basis for lipopolysaccharide O-antigen biosynthesis in bordetellae. (6/308)

Bordetella bronchiseptica and Bordetella parapertussis express a surface polysaccharide, attached to a lipopolysaccharide, which has been called O antigen. This structure is absent from Bordetella pertussis. We report the identification of a large genetic locus in B. bronchiseptica and B. parapertussis that is required for O-antigen biosynthesis. The locus is replaced by an insertion sequence in B. pertussis, explaining the lack of O-antigen biosynthesis in this species. The DNA sequence of the B. bronchiseptica locus has been determined and the presence of 21 open reading frames has been revealed. We have ascribed putative functions to many of these open reading frames based on database searches. Mutations in the locus in B. bronchiseptica and B. parapertussis prevent O-antigen biosynthesis and provide tools for the study of the role of O antigen in infections caused by these bacteria.  (+info)

Pertussis in the preantibiotic and prevaccine era, with emphasis on adult pertussis. (7/308)

Pertussis was first recognized as an epidemic disease in the 16th century. The classic illness is a three-stage illness (catarrhal, spasmodic, and convalescent), with a distinctive cough, and its characteristics today are similar to those in the prevaccine era. In the prevaccine era, the calculated attack rate was 872/100,000 population, and the majority of cases occurred in children <5 years of age. On average, there were 7,300 deaths/year; the death rate began to decline before antimicrobial therapy and vaccination. Reported pertussis in adults was rare, but numerous investigators noted that atypical cases of pertussis were common in adults.  (+info)

Parapertussis and pertussis: differences and similarities in incidence, clinical course, and antibody responses. (8/308)

OBJECTIVES: To compare the incidence, clinical course, and serologic response to Bordetella antigens in patients with parapertussis and pertussis. DESIGN: Two studies were performed in Sweden during the 1990s, when pertussis vaccines were used only in clinical trials. Study I was a retrospective study of patients with positive Bordetella cultures obtained in clinical routine, and study II involved an active search for patients with Bordetella infections during a placebo-controlled trial of a pertussis toxoid vaccine. RESULTS: Study I includes 58, and study II 23 patients with parapertussis. In study I, the incidence of parapertussis was 0.016 cases per 100 person years in children 0 to 6 years old and 0 in older children and adults. In study II, the incidence rates of parapertussis and pertussis were 0.2 and 16.2 per 100 person years, respectively, in children followed from 3 months to 3 years of age. The median number of days with cough was 21 in parapertussis and 59 in pertussis. The proportions of children with whooping and vomiting were lower in parapertussis than in pertussis. Geometric mean serum filamentous hemagglutinin IgG increased from 6 to 63, and pertactin IgG from 4 to 12 units/mL in parapertussis patients, which was similar to increases in children with pertussis. CONCLUSIONS: Disease caused by Bordetella parapertussis is diagnosed less commonly and is milder and of shorter duration than disease caused by Bordetella pertussis. Parapertussis induced serum IgG against filamentous hemagglutinin and pertactin of similar magnitude as does pertussis, and did not induce serum IgG against pertussis toxin.  (+info)

The Sanger Institute has been funded by the Wellcome Trust to sequence the genomes of Bordetella pertussis strain Tohama I, B. parapertussis strain 12822 and B. bronchiseptica strain RB50 in collaboration with Duncan Maskell and Andrew Preston of the Centre for Veterinary Science, Dept. of Clinical Veterinary medicine, The University of Cambridge. The sequences and analysis are described in: Parkhill et al (2003) Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nature Genetics 35 32-40 (DOI: 10.1038/Ng1227), and have been submitted to EMBL/GenBank with the accession numbers: BX470248 (B. pertussis), BX470249 (B. parapertussis) and BX470250 (B. bronchiseptica). The three sequenced Bordetella strains have been deposited with the ATCC and NCTC under the following accession numbers: Bordetella parapertussis 12822: ATCC BAA-587, NCTC 13253 Bordetella bronchiseptica RB50: ATCC BAA-588, NCTC 13252 Bordetella pertussis Tohama ...
We describe the epidemiology of a pertussis outbreak in Japan in 2010-2011 and Bordetella holmesii transmission. Six patients were infected; 4 patients were students and a teacher at the same junior high school. Epidemiologic links were found between 5 patients. B. holmesii may have been transmitted from person to person.
We report the repeated isolation of Bordetella petrii in the sputum of a 79-year-old female patient with diffuse bronchiectasis and persistence of the bacterium for >1 year. The patient was first hospitalized due to dyspnea, which developed into seve ...
Of the 10 identified species in the genus Bordetella, only four are of major medical significance. B. pertussis infects only humans and is the most important Bordetella species causing human disease. B. parapertussis causes an illness in humans that is similar to pertussis but is typically milder; co-infections with B. parapertussis and B. pertussis have been documented. With improved polymerase chain reaction (PCR) diagnostic methodology, up to 20% of patients with a pertussis-like syndrome have been found to be infected with B. holmesii, formerly thought to be an unusual cause of bacteremia. B. bronchiseptica is an important pathogen of domestic animals that causes kennel cough in dogs, atrophic rhinitis and pneumonia in pigs, and pneumonia in cats. Both respiratory infection and opportunistic infection due to B. bronchiseptica are occasionally reported in humans. B. petrii, B. hinzii, and B. ansorpii have been isolated from patients who are immunocompromised. ...
Using antisera raised against serotype 2 and 3 fimbrial subunits from Bordetella pertussis, serologically related polypeptides were detected in Bordetella bronchiseptica, Bordetella parapertussis and Bordetella avium strains. The two B. pertussis fimbrial subunits, and three of the serologically related B. bronchiseptica polypeptides, were shown to be very similar in amino ... read more acid composition and N-terminal amino acid sequence. Homology was observed between the N-termini of these polypeptides, and fimbrial subunits from Escherichia coli, Haemophilus influenzae and Proteus mirabilis. A synthetic oligonucleotide probe, derived from the N-terminal sequence of the B. pertussis serotype 2 fimbrial subunit, was used to identify fimbrial genes in genomic Southern blots. The results suggested the presence of multiple fimbrial subunit genes in B. pertussis, B. bronchiseptica and B. parapertussis. The DNA probe was used to clone one of the three tentative fimbrial subunit genes detected in B. ...
Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated genes (cas) are widely distributed among bacteria. These systems provide adaptive immunity against mobile genetic elements specified by the spacer sequences stored within the CRISPR. The CRISPR-Cas system has been identified using Basic Local Alignment Search Tool (BLAST) against other sequenced and annotated genomes and confirmed via CRISPRfinder program. Using Polymerase Chain Reactions (PCR) and Sanger DNA sequencing, we discovered CRISPRs in additional bacterial isolates of the same species of Bordetella. Transcriptional activity and processing of the CRISPR have been assessed via RT-PCR. Here we describe a novel Type II-C CRISPR and its associated genes-cas1, cas2, and cas9-in several isolates of a newly discovered Bordetella species. The CRISPR-cas locus, which is absent in all other Bordetella species, has a significantly lower GC-content than the genome-wide average, suggesting acquisition of this locus via
Bordetella is a genus of small (0.2 - 0.7 µm), Gram-negative coccobacilli of the phylum Proteobacteria. Bordetella species, with the exception of B. petrii, are obligate aerobes, as well as highly fastidious, or difficult to culture. All species can infect humans. The first three species to be described (B. pertussis, B. parapertussis, B. bronchiseptica,); are sometimes referred to as the classical species. One of these (B. bronchiseptica) is also motile. B. pertussis and occasionally B. parapertussis cause pertussis or whooping cough in humans, and some B. parapertussis strains can colonise sheep. B. bronchiseptica rarely infects healthy humans, though disease in immunocompromised patients has been reported. B. bronchiseptica causes several diseases in other mammals, including kennel cough and atrophic rhinitis in dogs and pigs, respectively. Other members of the genus cause similar diseases in other mammals, and in birds (B. hinzii, B. avium). The Bordetella genus is named after Jules ...
The genus Bordetella comprises several bacterial species that colonize the respiratory tract of mammals. It includes B. pertussis, a human-restricted pathogen that is the causative agent of Whooping Cough. In contrast, the closely related species B. bronchiseptica colonizes a broad range of animals as well as immunocompromised humans. Recent metagenomic studies have identified known and novel bordetellae isolated from different environmental sources, providing a new perspective on their natural history. Using phylogenetic analysis, we have shown that human and animal pathogenic bordetellae have most likely evolved from ancestors that originated from soil and water. Our recent study found that B. bronchiseptica can evade amoebic predation and utilize Dictyostelium discoideum as an expansion and transmission vector, which suggests that the evolutionary pressure to evade the amoebic predator enabled the rise of bordetellae as respiratory pathogens. Interactions with amoeba may represent the starting point
ID A0A0H4W4T7_9BORD Unreviewed; 231 AA. AC A0A0H4W4T7; DT 14-OCT-2015, integrated into UniProtKB/TrEMBL. DT 14-OCT-2015, sequence version 1. DT 22-NOV-2017, entry version 16. DE SubName: Full=DnaA regulatory inactivator Hda {ECO:0000313,EMBL:AKQ57115.1}; GN Name=hda {ECO:0000313,EMBL:AKQ57115.1}; GN ORFNames=ACR54_03827 {ECO:0000313,EMBL:AKQ57115.1}; OS Bordetella hinzii. OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Alcaligenaceae; Bordetella. OX NCBI_TaxID=103855 {ECO:0000313,EMBL:AKQ57115.1, ECO:0000313,Proteomes:UP000036382}; RN [1] {ECO:0000313,Proteomes:UP000036382} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=F582 {ECO:0000313,Proteomes:UP000036382}; RA Weigand M.R., Changayil S., Kulasekarapandian Y., Batra D., RA Williams M.M., Tondella M.L.; RT Complete Genome Sequences of Two Bordetella hinzii Isolated from RT Humans.; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the DnaA family. CC ...
ID BORPD_1_PE2941 STANDARD; PRT; 486 AA. AC BORPD_1_PE2941; A9ISA6; DT 00-JAN-0000 (Rel. 1, Created) DT 00-JAN-0000 (Rel. 2, Last sequence update) DT 00-JAN-0000 (Rel. 3, Last annotation update) DE SubName: Full=Putative transmembrane efflux protein; (BORPD_1.PE2941). GN OrderedLocusNames=Bpet2935; OS BORDETELLA PETRII DSM 12804. OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Alcaligenaceae; Bordetella. OX NCBI_TaxID=340100; RN [0] RP -.; RG -.; RL -.; CC -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BORPD_1.PE2941. CC Bordetella petrii DSM 12804, complete genome. CC complete sequence. CC -!- ANNOTATIONS ORIGIN:A9ISA6_BORPD CC -!- GENE_FAMILY: HOG000239124 [ FAMILY / ALN / TREE ] DR UniProtKB/Swiss-Prot; A9ISA6; -. DR EMBL; AM902716; CAP43277.1; -; Genomic_DNA. DR RefSeq; YP_001631545.1; NC_010170.1. DR ProteinModelPortal; A9ISA6; -. DR STRING; A9ISA6; -. DR GeneID; 5820419; -. DR GenomeReviews; AM902716_GR; Bpet2935. DR KEGG; bpt:Bpet2935; -. DR OMA; TSTHTIG; -. DR ...
Citation. Linz B, Ivanov YV, Preston A, Brinkac L, Parkhill J, Kim M, Harris SR, Goodfield LL, Fry NK, Gorringe AR, Nicholson TL, Register KB, Losada L, Harvill ET. Acquisition and Loss of Virulence-associated Factors During Genome Evolution and Speciation in Three Clades of Bordetella Species.. BMC Genomics. 2016 Sep 30; 17: 767.. External Citation. Abstract. The genus Bordetella consists of nine species that include important respiratory pathogens such as the classical species B. bronchiseptica, B. pertussis and B. parapertussis and six more distantly related and less extensively studied species. Here we analyze sequence diversity and gene content of 128 genome sequences from all nine species with focus on the evolution of virulence-associated factors.. ...
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
ID Q7WA27_BORPA Unreviewed; 245 AA. AC Q7WA27; DT 01-OCT-2003, integrated into UniProtKB/TrEMBL. DT 01-OCT-2003, sequence version 1. DT 08-MAY-2019, entry version 87. DE SubName: Full=Probable transcriptional regulator {ECO:0000313,EMBL:CAE36865.1}; GN OrderedLocusNames=BPP1563 {ECO:0000313,EMBL:CAE36865.1}; OS Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253). OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Alcaligenaceae; Bordetella. OX NCBI_TaxID=257311 {ECO:0000313,Proteomes:UP000001421}; RN [1] {ECO:0000313,Proteomes:UP000001421} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=12822 / ATCC BAA-587 / NCTC 13253 RC {ECO:0000313,Proteomes:UP000001421}; RX PubMed=12910271; DOI=10.1038/ng1227; RA Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N., RA Harris D.E., Holden M.T., Churcher C.M., Bentley S.D., Mungall K.L., RA Cerdeno-Tarraga A.M., Temple L., James K., Harris B., Quail M.A., RA Achtman M., Atkin R., Baker S., Basham D., ...
BLOT kit for the detection of specific IgG antibodies to the recombinant antigens of Bordetella pertussis and Bordetella parapertussis in human serum and plasma, for automated processing using the BlueDiver Instrument.
Looking for Bordetella? Find out information about Bordetella. A genus of gram-negative bacteria which are coccobacilli and obligate aerobes, and fail to ferment carbohydrates. These bacteria are respiratory pathogens.... Explanation of Bordetella
Definition : Molecular assay reagents intended to identify species of Bordetella, a genus of gram-negative coccobacillus bacteria, by detecting specific nucleic-acid information of the target bacteria. Some species of these bacteria may cause infections in the human respiratory tract, including whooping cough.. Entry Terms : Whooping Cough Diagnostic Reagents , Pertussis Diagnostic Reagents , Parapertussis Diagnostic Reagents , Bordetella Species Detection/Identification Reagents , Reagents, Molecular Assay, Infection, Bacteria, Bordetella Species. UMDC code : 21449 ...
Bordetella Vaccines - Bordetella vaccines will ensure your pet doesnt come down with kennel cough. Learn more about bordetella vaccines and treatments.
When and how often laboratory tests are done may depend on many factors. The timing of laboratory tests may rely on the results or completion of other tests, procedures, or treatments. Lab tests may be performed immediately in an emergency, or tests may be delayed as a condition is treated or monitored. A test may be suggested or become necessary when certain signs or symptoms appear. Due to changes in the way your body naturally functions through the course of a day, lab tests may need to be performed at a certain time of day. If you have prepared for a test by changing your food or fluid intake, lab tests may be timed in accordance with those changes. Timing of tests may be based on increased and decreased levels of medications, drugs or other substances in the body. The age or gender of the person being tested may affect when and how often a lab test is required. Chronic or progressive conditions may need ongoing monitoring through the use of lab tests. Conditions that worsen and improve may ...
We report 2 cases of pulmonary Bordetella hinzii infection in immunodeficient patients. One of these rare cases demonstrated the potential transmission of the bacteria from an avian reservoir through occupational exposure and its persistence in humans. We establish bacteriologic management of these infections and suggest therapeutic options if needed ...
Significance Diversity-generating retroelements (DGRs) are in vivo sequence diversification machines that are widely distributed in bacteria, archaea, and their viruses. DGRs use a reverse transcriptase (RT)-mediated mechanism to diversify protein-encoding genes to facilitate adaptation of their hosts to changing environments. Here, we demonstrate that the Bordetella phage DGR-encoded RT uses the 3′-OH of a nicked template RNA to initiate reverse transcription, during which random nucleotides are incorporated when adenine residues in the template are copied into complementary DNA (cDNA). We further show that this mutated, covalently linked RNA-cDNA molecule is required for DGR-mediated sequence diversification, revealing a mechanism of accelerated evolution with broad practical applications. Diversity-generating retroelements (DGRs) are molecular evolution machines that facilitate microbial adaptation to environmental changes. Hypervariation occurs via a mutagenic retrotransposition process from a
Range of activities Publications Research projects International cooperation Participation in the European research group Eupertgenomics / Eupertstrain, which brings together experts from leading centers in Europe dealing with issues of infections caused by bacteria of the genus Bordetella pertussis and illnesses and
Bordetella is a vaccine that helps to protect against bacterial pneumonia and kennel cough. This is the vaccine that your dog generally gets administered by drops in the nose. There is also a vaccine that can be given under the skin via injection. Ask your veterinarian which vaccine is best for your dog. ...
Many known or suspected bacterial virulence factors require environmentally responsive control factors for expression. In Bordetella species, the BvgAS system represses and activates sets of genes, and mediates a biphasic phenotypic transition. Studies using mutants with altered signaling pathways and reversed regulatory connections have provided insights into the role of BvgAS and this phenotypic transition during the Bordetella-host interaction.
When it comes to vaccinations, many pet parents want to know exactly what their dog is being protected against. Embrace can help you out.
Bordetella parapertussis ATCC ® 15311D-5™ Designation: Genomic DNA from Bordetella parapertussis Strain 522 TypeStrain=True Application:
Bordetella parapertussis: | | | | |Bordetella parapertussis| | | ... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled.
Looking for Bordetella avium? Find out information about Bordetella avium. A nonsporulating, gram-negative coccobacillus that causes respiratory infections in birds Explanation of Bordetella avium
ICD-10 A37.11 is whooping cough due to bordetella parapertussis with pneumonia (A3711). This code is grouped under diagnosis codes for certain infectious and parasitic diseases.
A37.11 ICD 10 CM Code for Whooping cough due to Bordetella parapertussis with pneumonia, Convert ICD 10 CM code A37.11 to ICD 9 CM code.
1ZBO: X-Ray Crystal Structure of Protein BPP1347 from Bordetella parapertussis. Northeast Structural Genomics Consortium Target BoR27.
Coloured scanning electron micrograph (SEM) of Bordetella bronchiseptica, Gram-negative, aerobic, motile, coccobacillus prokaryote (bacterium). Bordetella bronchiseptica typically infects the respiratory tracts of smaller mammals (cats, dogs, rabbits). It causes infectious bronchitis, but rarely infects humans. It does not express pertussis toxin, which is one of the characteristic virulence factors of B. pertussis. It is related to Bordetella pertussis, the obligate human pathogen, that causes pertussis or whooping cough. B. bronchiseptica does not express pertussis toxin, which is one of the characteristic virulence factors of B. pertussis. Humans are not natural carriers of B. bronchiseptica. Magnification: x4,400 when shortest axis printed at 25 millimetres. - Stock Image C032/2756
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Bordetella bronchiseptica ATCC ® BAA-588D-5™ Designation: Genomic DNA from Bordetella bronchiseptica strain RB50 TypeStrain=False Application:
The genus Bordetella consists of Gram-negative β-proteobacteria, including the three human pathogens Bordetella pertussis, Bordetella parapertussis an...
DEMONSTRATION OF ONE YEAR DURATION-OF-IMMUNITY FOR A FELINE BORDETELLA BRONCHISEPTICA VACCINE. J.R. Williams, R. Laris. OBJECTIVE: The objective of this study was to determine the ability of a modified live intranasal Bordetella bronchiseptica vaccine (Nobivac-Bb) to prevent disease in cats for a period of one year following vaccination. EXPERIMENTAL DESIGN: Forty-eight cats were vaccinated according to manufacturers instructions. Twenty-four vaccinated cats and 12 controls were challenged with a virulent strain of B. bronchiseptica six-months after vaccination, and two additional groups of vaccinates and controls were challenged one year after vaccination. Clinical signs were recorded daily for two weeks after challenge, and clinical scores were calculated for each group. The Mann-Whitney U test was used to determine if clinical scores in the vaccinated groups were significantly different from scores in the control groups. RESULTS: The mean clinical score for vaccinated cats at six-months ...
5] Binns, S. H., Corkill, J. E., Dawson, S., Gaskell, R. M., Hart, C. A., Kariuki, S., Osborn, A. M., Saunders, J. R., and Speakman, A. J. 1997. Characterization of antibiotic resistance plasmids from Bordetella bronchiseptica. Journal of Antimicrobial Chemotherapy. 40: 811-816. [[6] Appel J. G. M., Bemis, A. D., and Greisen, A. H. 1977. Pathogenesis of canine bordetellosis. The Journal of Infectious Diseases. 135: 753-762. [[7] Vanderzee, A, Mooi, F., Emben, J. V., and Musser, J. Molecular evolution and host adaptation of Bordetella spp.: phylogenetic analysis using multilocus enzyme electrophoresis and typing with three insertion sequences. 1997. Journal of Bacteriology. 179: 6609-6617. [[8] Roberts, M., and Stevenson, A. 2003. Use of Bordetella bronchiseptica and Bordetella pertussis as live vaccines and vectors for heterologous antigens. FEMS Immunology and Medical Microbiology. 37: 121-128. [[9] Arico, B. and Rappuoli, R. Bordetella parapertussis and Bordetella ...
|EM>Bordetella pertussis|/EM>, |EM>Bordetella parapertussis|/EM> and |EM>Bordetella bronchiseptica|/EM> are closely related Gram-negative Beta-proteobacteria that colonizes the respiratory tracts of mammals. |EM>B. parapertussis|/EM> causes whooping cough in a wide range of animals. D-Alanine is a necessary precursor in the biosynthesis of cell [...]
Members of the Bordetella genus alternate between two distinct phenotypic phases in response to changes in their environment. This switch, termed phenotypic modulation, is mediated by the BvgAS sensory transduction system. We developed an animal model based on the interaction of Bordetella bronchiseptica with one of its natural hosts, the rabbit. To investigate the importance of BvgAS signal transduction, we constructed constitutive (RB53) and Bvg- (RB54) phase-locked derivatives of a wild-type strain, RB50. RB50 and RB53, but not RB54, established respiratory infections in B. bronchiseptica-free rabbits with an intranasal 50% infective dose of less than 200 organisms, and the course of the infection closely resembled that observed with naturally infected rabbits. Bacteria were recovered from the nasal cavity, larynx, trachea, and lungs in similar numbers from RB50- and RB53-infected rabbits, yet no pathology was detected by histological examination of lung and tracheal sections. The antibody ...
Biotin (vitamin H or vitamin B7) is the essential cofactor of biotin-dependent carboxylases, such as pyruvate carboxylase and acetyl-CoA carboxylase. Mammals cannot synthesize biotin, while in bacteria, fungi, and plants it is synthesized from pimelate thioester through different pathways. In E. coli and many organisms, pimelate thioester is derived from malonyl-ACP. The pathway starts with the methylation to malonyl-ACP methyl ester, followed by the fatty acid chain elongation cycle to form pimeloyl-ACP methyl ester, which is then demethylated to form pimeloyl-ACP [MD:M00572]. Pimeloyl-ACP is converted to biotin through the final four steps in the biotin bicyclic ring assembly, which are conserved among biotin-producing organisms [MD:M00123]. In B. subtilis, biotin is derived from pimeloyl-ACP formed by oxidative cleavage of long-chain acyl-ACPs [MD:M00573]. Some bacteria synthesize biotin from pimeloyl-CoA derived from pimelate [MD:M00577]. Biotin is covalently attached to biotin-dependent ...
Nobivac Feline-Bb is for the intranasal vaccination of healthy kittens and cats for prevention of disease caused by Bordetella bronchiseptica. B. bronchiseptica acts as a primary or secondary pathogen in feline respiratory disease.
Bordetella pertussis is an aerobic gram-negative bacterial pathogen that causes the human respiratory disease whooping cough. Despite widespread vaccination, whooping cough is reemerging due to decreased vaccine efficacy. One of the hallmarks of infection is lymphocytosis, which is induced by the pertussis toxin. Lymphocytes such as CD4+ T cells navigate to infected tissues through surface-trafficking molecules, which are imprinted during their interaction with tissue-associated dendritic cells. We hypothesized that the pertussis toxin affects the imprinting process resulting in altered expression of trafficking molecules on CD4+ T cells. We tested this hypothesis using a mouse model of infection. Imprinting levels on CD4+ T cells were compared to Bordetella parapertussis, a related strain that lacks pertussis toxin. Our results indicated that 5 days post-infection, the percentage of lung dendritic cells increased and adopted a mature phenotype (displaying an increased capability to migrate and present
A Gram negative species of bacteria, Campylobacter jejuni, is the leading cause of food poisoning worldwide. Humans often contract food poisoning after ingesting contaminated poultry. Detecting the presence of C. jejuni in poultry is difficult because it is part of the natural flora and does not cause symptomatic infection. In a related manner, Bordetella avium is a Gram negative species of bacteria that causes bordetellosis in poultry. This disease is similar to whooping cough caused by the related pathogen of humans, B. pertussis. Though the mortality rate for bordetellosis is low, it weakens the birds immune systems, often leading to secondary infections. The aim of this project was to construct a vaccine platform capable of immunizing poultry against both pathogens-B. avium and C. jejuni-thus reducing disease in birds and humans. A heterologous construct can be made utilizing the B. avium autotransporter Baa1 that plays a role in host cell attachment. Autotransporters are comprised of three genetic
Domain architecture and assignment details (superfamily, family, region, evalue) for gi|187478965|ref|YP_786989.1| from Bordetella avium 197N. Plus protein sequence and external database links.
Free, official coding info for 2018 ICD-10-CM A37.11 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
2KAT: Solution structure of protein BPP2914 from Bordetella parapertussis. Northeast Structural Genomics Consortium target BpR206
The Global and Chinese Bordetella Pertussis Industry, 2011-2021 Market Research Report is a professional and in-depth study on the current state of the global Bordetella Pertussis industry with a focus on the Chinese market. The report provides key statistics on the market status of the Bordetella Pertussis manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.. Complete report of 150 pages published in Jan 2016 is available at http://www.market-research-reports.com/434778-bordetella-pertussis-industry.. Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. Then, the report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 2011-2016 market shares for each company. Through the statistical analysis, the report depicts the ...
Bordetella are small Gram-negative coccobacilli, of which Bordetella pertussis is the most important human pathogen. It is the cause of whooping cough, which is one of the 10 leading causes of childhood death. Transmission of this highly infectious organism is primarily by aerosolized droplets.Clinical features-presentation varies with age, immunization and previous infection: (1) infants-apnoea, cyanosis, and paroxysmal cough; (2) nonimmunized children-cough, increasing in severity with distressing, repeated, forceful expirations followed by a gasping inhalation (the whoop); (3) children immunized in infancy-whooping, vomiting, sputum production; (4) adults-cough, post-tussive vomiting. Atypical mild illness is common. Complications include pneumonia, pulmonary hypertension, seizures and encephalopathy. Most deaths occur in those less than 2 months old....
Bordetella pertussis, small coccoid gram-negative rod-shaped bacteria, is the causative agent of pertussis, a respiratory disease. The bacteria are transmitted by droplet infection from individual to individual. The disease mainly affects children in the age of 0-4 years. It shows a high lethality in newborns. The Immunolab Bordetella pertussis IgG/IgM/IgA ELISAs are quantitative and qualitative tests for the…
Bordetella pertussis (whooping cough) - no known animal or environmental reservoir (Mattoo and Cherry 2005 - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082800/ ). Bordetella bronchiseptica, B. parapertussis, and B. holmesii are associated with respiratory infections in humans and other mammals - B. bronchiseptica is a major cause of kennel cough in dogs (Mattoo and Cherry 2005 - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1082800/ ). Polio can infect primates: http://jid.oxfordjournals.org/content/175/Supplement_1/S286.full.pdf. Measles: no animal or environmental reservoir is known to exist however Many primate species are susceptible to measles virus infection http://jid.oxfordjournals.org/content/204/suppl_1/S47.full.pdf+html. Cholera: aquatic plants, animals, and sediments (zzoplankton largest known) http://onlinelibrary.wiley.com/doi/10.1111/j.1758-2229.2009.00128.x/abstract. Humans are the only natural reservoir for N. ...
Differentiation of Bvg-regulated gene expression.Comparative global expression analysis revealed unexpected complexity of the Bordetella BvgAS regulon and insights into possible evolutionary paths for virulence regulation among strains and species of an important group of bacterial pathogens. In particular, B. bronchiseptica, a pathogen and persistent commensal in a broad set of animal species, displayed a wide variety of gene expression profiles in vitro. These profiles may reflect spatially and/or temporally defined patterns during the infectious cycle. The spatial model proposes that colonization of different airway niches and the process of transmission require overlapping yet distinct sets of gene products, the expression of which is regulated by BvgAS in response to environmental conditions characteristic of those anatomic locations. Alternatively, or in addition, BvgAS may regulate a gene expression program in a temporally defined manner, facilitating the establishment of infection (49). ...
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
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Directly proving aP vaccination puts treated people at risk of acquiring B. parapertussis is very difficult, but we hope our study highlights the need for more thorough B. parapertussis epidemiological data and encourages further work in this neglected area. If our experiments are capturing the phenomenology of what is happening under aP vaccination in humans, it may be important to consider the introduction of vaccines that better protect against both bordetellae; for example, live attenuated B. pertussis nasal vaccines (Mielcarek et al. 2006), wP vaccines containing both B. pertussis and B. parapertussis (Burianova-Vysoka et al. 1970), or supplementation of aP vaccines with B. parapertussis protective antigens (Zhang et al. 2009a). An enhanced understanding of the evolutionary consequences of widespread aP vaccination is needed in order to optimize the next generation of vaccination strategies and fully reap the benefits of this powerful medical intervention ...
Bordetella pertussis ASR,The B. pertussis ASR contains primers and a FAM-labeled probe that is designed to detect a 103 bp region of the IS481 gene. In addition, the B. pertussis ASR contains primers, a Texas Red-labeled probe and DNA for an internal control sequence. This ASR requires an instrument that can detect FAM and,medicine,medical supply,medical supplies,medical product
Escaneado de imágenes de microscopio electrónico de Bordetella pertussis - Gram-negativa, aerobia, no móviles, cocobacilos procariotas (bacterias) que causa la tosferina o pertussis. Sobre la técnica de imagen: Las tecnologías modernas tales como la microscopía electrónica puede dar detalles más finos de las bacterias que la microscopía óptica (luz) e incluso puede ser utilizado para mostrar las características internas. Las micrografías electrónicas son imágenes en blanco y negro generados por los rayos de alta energía de electrones. Las micrografías a veces se les da un color falso para que sean visualmente atractivo (en este caso, se utilizó un tinte verde).. ...
Endotoxins are lipopolysaccharides (LPS), and major constituents of the outer membrane of Gram-negative bacteria. Bordetella pertussis LPS were the only major
False colour transmission electron micrograph of the whooping cough bacterium, Bordetella pertussis. The micrograph shows the bacteriums surface covered in fine hairs called pili or frimbriae. Several types of pili have been identified, based on shape & function. Generally, pili cause bacteria to stick together & attach to foreign cells in the body. The fragments around the bacterium are bits of the growth medium. The whooping cough bacteria parasitise only humans, causing a respiratory tract infection characterised by fits of coughing that end in loud inspiratory whoops. It is potentially fatal in infancy. Magnification: X 20,600 at 35mm size. Original is bw print b220/213. - Stock Image B220/0213
Catalytic and Structural Insights into Toxin Activation by the Bordetella pertussis CyaC-Acyltransferase av Dr. Niramon Thamwiriyasati Burapha University (BUU), Faculty of Allied Health Sciences, Chonburi, Thailand.
The heterohybridoma cell line HBp2 secreting human monoclonal antibody (hMAb) directed against Bordetella pertussis was generated by fusing SP2/HPT heteromyeloma cells with human spleen lymphocytes, after in vitro stimulation for 6 days. The hybridoma was maintained in culture for more than 1 year w …
There was a report out yesterday that the cases of whooping cough (Bordetella pertussis) in Minnesota have doubled from last month and by May, have exceeded all cases reported there last year. There have been 700 cases so far this … Continue reading →. ...
Dynamics of the population structure of Bordetella pertussis as measured by IS1002-associated RFLP: comparison of pre- and post-vaccination strains and global distribution
Biohazard level, growth media and temperature, gram stain, industrial applications and more information for Bordetella pertussis.
La tos ferina es una enfermedad del tracto respiratorio que se presenta exclusivamente en los seres humanos y es causada por la bacteria gramnegativa Bordetella pertusis.
The determination of the genome sequences of B. pertussis, B. parapertussis, and B. bronchiseptica was completed and the sequences were reported in 2003 by Parkhill et al. (18). We utilized early (August 2001) assemblies of these genome sequences to search for PCR target sequences that might be specific to B. pertussis. Two regions with significant sequence divergence were identified and utilized for the design of the BP283 and BP485 real-time PCR assays. Notably, the diagnostic potential of the region used for the design of our BP485 assay was also predicted previously by others using microarray-based comparative genome hybridization (4). Similarly, previous work using representational difference analysis described the genome region encompassing the BP283 target sequence as being specific to B. pertussis (15). Both assays demonstrated excellent sensitivities and specificities when applied to clinical isolates and nasopharyngeal specimens. In contrast to the IS481 assay, the BP283 and BP485 ...
Bordetella parapertussis shows the most similarity to B. pertussis and was therefore used for research determining the role of ... One difference between the different species of Bordetella is that B. pertussis produces PT and the other species do not. ... Bagley K, Abdelwahab S, Tuskan R, Fouts T, Lewis G (2002). "Pertussis toxin and the adenylate cyclase toxin from Bordetella ... Finger H, von Koenig CH (1996). "Bordetella". In Barron S, et al. (eds.). Barron's Medical Microbiology (4th ed.). Univ of ...
"Comparison of modified Bordet-Gengou and modified Regan-Lowe media for the isolation of Bordetella pertussis and Bordetella ... has replaced Bordet-Gengou medium as the medium of choice for routine Bordetella pertussis incubation. Bordetella bacteria were ... Bordet-Gengou agar is a type of agar plate optimized to isolate Bordetella, containing blood, potato extract, and glycerol, ... ISBN 0-9631172-1-1. BD Bordet Gengou Agar with 15% Sheep Blood (product insert also describing Bordetella Agar with Charcoal) ...
Bordetella sp., Enterobacter sp., most Haemophilus sp., most Klebsiella sp., Neisseria sp., Mannheimia haemolytica, Pasteurella ...
Bordetella pertussis 1. She was a full professor of biomedicine at Mucosal Immunology and Vaccine Center in Gothenburg. ...
"Bordetella bronchialis sp. nov., Bordetella flabilis sp. nov. and Bordetella sputigena sp. nov., isolated from human ...
... is an adenylate cyclase produced by Bordetella pertussis. Kessin RH, Franke J (April 1986). " ... Ladant D, Brezin C, Alonso JM, Crenon I, Guiso N (December 1986). "Bordetella pertussis adenylate cyclase. Purification, ... "Secreted adenylate cyclase of Bordetella pertussis: calmodulin requirements and partial purification of two forms". J. ...
In Bordetella pertussis, the infectious agent in childhood whooping cough, filamentous haemagglutinin (FHA) is a surface- ... Inatsuka CS, Julio SM, Cotter PA (December 2005). "Bordetella filamentous hemagglutinin plays a critical role in ... "Filamentous hemagglutinin of Bordetella pertussis. A bacterial adhesin formed as a 50-nm monomeric rigid rod based on a 19- ... "Beta-helix model for the filamentous haemagglutinin adhesin of Bordetella pertussis and related bacterial secretory proteins". ...
2003). "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella ... and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies". Clinical ... 1991). "Effects of Bordetella pertussis infection on human respiratory epithelium in vivo and in vitro". Infection and Immunity ... Luker, K. E.; Collier, J. L.; Kolodziej, E. W.; Marshall, G. R.; Goldman, W. E. (1993). "Bordetella pertussis Tracheal ...
Gentry-Weeks CR, Spokes J, Thompson J (March 1995). "beta-Cystathionase from Bordetella avium. Role(s) of lysine 214 and ...
Diseases such as pertussis (or whooping cough) are caused by the bacteria Bordetella pertussis. This bacteria is marked by a ... Yeh, Sylvia H.; Mink, ChrisAnna M. (2012). "Bordetella pertussis and Pertussis (Whooping Cough)". Netter's Infectious Diseases ...
Betaproteobacteria: Bordetella, Ralstonia, Neisseria, Nitrosomonas, etc. Gammaproteobacteria: Escherichia, Shigella, Salmonella ...
Corynebacterium diphtheriae and Bordetella pertussis. ubiquitination and SUMOylation Various full-length, folded proteins can ...
... s have been suggested as antimicrobials able to remove Bordetella bronchiseptica biofilms. The mode of killing has ... Irie Y, O'toole GA, Yuk MH (September 2005). "Pseudomonas aeruginosa rhamnolipids disperse Bordetella bronchiseptica biofilms ...
... with probiotics against Bordetella bronchiseptica in mice". The Journal of Veterinary Medical Science. 72 (9): 1195-202. doi: ...
Pertussis is caused by the bacterium Bordetella pertussis. It is spread easily through the coughs and sneezes of an infected ... Pertussis is caused by the bacterium Bordetella pertussis. It is an airborne disease (through droplets) that spreads easily ...
The bacterial genus Bordetella is named after him. The Nobel Prize in Physiology or Medicine was awarded to him in 1919 for his ... With Octave Gengou, he isolated Bordetella pertussis in pure culture in 1906 and posited it as the cause of whooping cough. He ...
The bacterium Bordetella pertussis was first identified as the cause of whooping cough and isolated by Jules Bordet and Octave ... Guiso N. 2009.Bordetella pertussis and pertussis vaccines. Clin. Infect. Dis. 49:1565-1569 "1.C.72 The Pertussis Toxin (PTX) ... Pertussis toxin is secreted by the gram-negative bacterium, Bordetella pertussis. Whooping cough is very contagious and cases ... Carbonetti, N. H. (2010). "Pertussis toxin and adenylate cyclase toxin: Key virulence factors of Bordetella pertussis and cell ...
The Bordetella phages of this genus contains an RNA-directed DNA polymerase which plays a role in tropism. Viral replication is ... The genus currently contains only one species, Bordetella virus BPP1, which also serves as its type species. Group: dsDNA Order ... Caudovirales Family: Podoviridae Genus: Rauchvirus Bordetella virus BPP1 Viruses in Rauchvirus are non-enveloped, with ... "Three-dimensional structure of tropism-switching Bordetella bacteriophage". Proceedings of the National Academy of Sciences. ...
It included whole-cell killed Bordetella pertussis bacteria. Until the beginning of the 1990s it was used as a part of the DTwP ... protective efficacy and tolerability in the prevention of Bordetella pertussis infection". Drugs. 52 (2): 254-275. doi:10.2165/ ...
With Jules Bordet he isolated Bordetella pertussis in pure culture in 1906 and declared it as the cause of whooping cough. In ... He researched with Jules Bordet the Bordetella pertussis bacteria. At the age of 22, he obtained his doctorate at the ...
PRN is purified from Bordetella pertussis and is used for the vaccine production as one of the important components of ... Emsley, P.; Charles, I. G.; Fairweather, N. F.; Isaacs, N. W. (1996). "Structure of Bordetella pertussis virulence factor P.69 ... Emsley P, Charles IG, Fairweather NF, Isaacs NW (May 1996). "Structure of Bordetella pertussis virulence factor P.69 pertactin ... In molecular biology, pertactin (PRN) is a highly immunogenic virulence factor of Bordetella pertussis, the bacterium that ...
Bordetella pertussis. Bordetella bronchiseptica and Bordetella parapertussis, also able to cause pertussis-like symptoms, also ... Vaccination against Bordetella pertussis is used in infancy to prevent whooping cough. The recent switch from whole-cell ... Adenylate cyclase toxin is a virulence factor produced by some members of the genus Bordetella. Together with the pertussis ... Differences between the toxins of different Bordetella species are mainly in the calcium-binding domain. The toxin is secreted ...
"Vaccine Development for the Control of Bordetella Pertussis Infections". Infection and Immunity. 86 (6): e00004-18. doi:10.1128 ...
Matsuzawa T, Kashimoto T, Katahira J, Horiguchi Y (July 2002). "Identification of a receptor-binding domain of Bordetella ... from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) is a toxin whose structure from Escherichia coli revealed a 4- ... Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibres and focal adhesions by deamidating or ...
"Interaction of human Tamm-Horsfall glycoprotein with Bordetella pertussis toxin". Microbiology. 148 (Pt 4): 1193-1201. doi: ...
Rhizobactin from Sinorhizobium Alcaligin from Bordetella J. B. Neilands (1995). "Siderophores: Structure and Function of ...
Orii C, Takenaka S, Murakami S, Aoki K (November 2006). "Metabolism of 4-amino-3-hydroxybenzoic acid by Bordetella sp. strain ...
One notable bacterium that produces filamentous haemagglutinin adhesin is Bordetella pertussis, which uses this protein as a ... a multifaceted adhesion produced by virulent Bordetella spp". Molecular Microbiology. 9: 653-60. doi:10.1111/j.1365-2958.1993. ...
This is known to be caused by the Bordetella bronchiseptica bacterium. Hedgehogs uncommonly transmit a characteristic fungal ...
These include Bordetella bronchiseptica, Streptococcus phocae, Salmonella dublin, and S. choleraesuis. Corynebacterium caspium ...
It is caused by the bacterium Bordetella pertussis.. Pertussis is known for uncontrollable, violent coughing which often makes ...
After 42 days, the dogs were exposed to Bordetella bronchiseptica. This study determined that the live intranasal Bordetella ... The Bordetella vaccine is also only about 70% effective (Bryant). There are 3 licensed ways to deliver the Bordetella vaccine ... The Bordetella vaccine specifically targets the genus and species Bordetella bronchiseptica, the species typically responsible ... and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies". Clin ...
2003). "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella ... Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus of the genus Bordetella, and the ... Nieves DJ, Heininger U (2016). "Bordetella pertussis". Bordetella pertussis. Microbiology Spectrum. 4. pp. 311-339. doi:10.1128 ... The genus Bordetella contains nine species: B. pertussis B. parapertussis, B. bronchiseptica, B. avium, B. hinzii, B. holmesii ...
Bordetella is commonly known as kennel cough, and spreads rapidly among shelter populations. "Shelters are often compelled by ... The Petfinder.com Foundation gives six shelters bordetella vaccination grants by Lisa, Petfinder Foundation executive director ... Recently, the Petfinder.com Foundation awarded six Petfinder shelters and rescue groups bordetella vaccination grants totaling ...
Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.. ... Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. B. pertussis, and occasionally B. parapertussis, ... Bordetella parapertussis 12822: ATCC BAA-587, NCTC 13253 Bordetella bronchiseptica RB50: ATCC BAA-588, NCTC 13252 Bordetella ... Bordetella. The genus Bordetella comprises Gram-negative beta-proteobacteria including three species which are human pathogens ...
Bacteremia due to Bordetella holmesii.. Morris JT1, Myers M.. Author information. 1. Department of Medicine, Madigan Army ...
Definition of Bordetella pertussis. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... Bordetella pertussis. Definition: the bacterial species that is the causative agent of whooping cough, a respiratory tract ...
... ,The B. pertussis ASR contains primers and a FAM-labeled probe that is designed to detect a 103 bp ... Bordetella pertussis Antibody, IgM. 5. Bordetella pertussis Antibody, IgG. 6. Bordetella pertussis by PCR. 7. Bordetella ... Bordetella pertussis DFA. 10. Bordetella pertussis Toxin Antibody, IgA. 11. Bordetella pertussis Toxin Antibody, IgG. ... Bordetella pertussis Antibodies, IgA & IgG. 2. Bordetella pertussis Antibodies, IgA, IgG, & IgM. 3. Bordetella pertussis ...
Bordetella bronchiseptica (Ferry 1912) Moreno-Lopez 1952. › Bordetella [email protected] › Brucella bronchiseptica. › Brucella ... Bordetella. Strains i. › 240/2. › 7865. › ATCC 31437 / Bb55. › ATCC 4617 / NCIB 9935 / NCTC 8344 / NRRL B-140, NCTC 8344. › ...
hypothetical protein Bpet2667 [Bordetella petrii DSM 12804]. * This record was replaced or removed. The sequence YP_001631277 ...
Bordetella Blast Server. Find out more about wu-blast Retrieve result for BLAST job id:. ...
New Species of Bordetella, Bordetella ansorpii sp. nov., Isolated from the Purulent Exudate of an Epidermal Cyst Kwan Soo Ko, ... Evaluation of Real-Time PCR for Detection of and Discrimination between Bordetella pertussis, Bordetella parapertussis, and ... Evaluation of Real-Time PCR for Detection of and Discrimination between Bordetella pertussis, Bordetella parapertussis, and ... Evaluation of the Aries Bordetella Assay for Detection and Identification of Bordetella pertussis in Nasopharyngeal Swab ...
... gram-negative coccobacilli of the genus Bordetella, some of which are pathogenic in the human respiratory tract. It includes B ... bordetella. bor·de·tel·la. noun. Any of various small, gram-negative coccobacilli of the genus Bordetella, some of which are ... plural bordetellas). *(biology) Any of several gram-negative coccobacilli, of the genus Bordetella, many of which are ... Origin of bordetella. New Latin Bordetella genus name after Jules Jean Baptiste Vincent Bordet (1870-1961), Belgian ...
Bordetella bronchialis sp nov., Bordetella flabilis sp nov and Bordetella sputigena sp nov., isolated from human respiratory ... We therefore propose to formally classify Bordetella genogroups 3, 14 and 15 as Bordetella bronchialis sp. nov. (type strain ... type strain LMG 28641(T)=CCUG 56478(T)) and Bordetella flabilis sp. nov. (type strain LMG 28642(T)=AU10664(T)=CCUG 56827(T)). ... The respiratory quinone, polar lipid and fatty acid profiles generally conformed to those of species of the genus Bordetella ...
Bordetella vaccines will ensure your pet doesnt come down with kennel cough. Learn more about bordetella vaccines and ... Like all vaccines, Bordetella works by injecting a small amount of the bacteria or virus into the bloodstream of the animal. ... One way you can help your dog, cat, guinea pig, rabbit or pig avoid kennel cough is by immunizing with the Bordetella vaccine. ... Most dogs probably prefer the nasal version of the Bordetella vaccine to the sting of the needle. ...
... , Whooping Cough Test, Pertussis Diagnostics, Pertussis Culture, Pertussis PCR, Bordatella PCR. ... Bordetella Pertussis Test. Bordetella Pertussis Test Aka: Bordetella Pertussis Test, Whooping Cough Test, Pertussis Diagnostics ... Bordetella Pertussis Test Colorimetric Capnometry Delta F508 Diffusing Capacity End-Tidal CO2 End-Tidal O2 Exercise Spirometry ... These images are a random sampling from a Bing search on the term "Bordetella Pertussis Test." Click on the image (or right ...
MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES SECTION I - INFECTIOUS AGENT NAME: Bordetella pertussis SYNONYM OR CROSS REFERENCE: Whooping cough, B. parapertussis CHARACTERISTICS: Gram-negative coccobacilli, aerobic, encapsulated, non-motile, produces a toxin; B. pertussis has fastidious growth requirements while B. parapertussis grows on simple culture media SECTION II - HEALTH HAZARD PATHOGENICITY: An acute respiratory disease with three stages: a catarrhal stage with an irritating cough, lasts 1 to 2 weeks; a paroxysmal stage characterized by violent coughs followed by a high pitched inspiratory whoop, lasts 2 to 6 weeks; a convalescent stage where the cough gradually decreases in frequency and severity, lasts several weeks; 75% of deaths are among infants; parapertussis is similar but milder, occurs in school-age children and is seen less frequently EPIDEMIOLOGY: Common in children worldwide; decline in incidence and mortality following immunization and where good nutrition and medical ...
Bordetella pertussis synonyms, Bordetella pertussis pronunciation, Bordetella pertussis translation, English dictionary ... definition of Bordetella pertussis. n. 1. A part that forms the outer edge of something. 2. A decorative strip around the edge ... Bordetella pertussis - definition of Bordetella pertussis by The Free Dictionary https://www.thefreedictionary.com/Bordetella+ ... redirected from Bordetella pertussis). Also found in: Thesaurus, Medical, Legal, Financial, Encyclopedia, Wikipedia. bor·der. ( ...
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in ... Bordetella pertussis Antibody, IgM. 5. Bordetella pertussis Antibody, IgG. 6. Bordetella pertussis by PCR. 7. Bordetella ... Bordetella pertussis ASR. 2. Bordetella pertussis Antibodies, IgA & IgG. 3. Bordetella pertussis Antibodies, IgG & IgM. 4. ... Bordetella pertussis DFA. 10. Bordetella pertussis Toxin Antibody, IgA. 11. Bordetella pertussis Toxin Antibody, IgG. ...
Bordetella Vaccine. Fortunately, a vaccine is available for Bordetella bronchiseptica. It may also be called a Bordetella shot ... Bordetella Vaccine Cost. Cost of the Bordetella vaccine depends on your area and the type of vaccine given (i.e. with or ... Bordetella Vaccine Schedule. How often Bordetella vaccine is given depends a little on your pets risk. For the most part, the ... Bordetella Vaccine Side Effects. Serious Bordetella or kennel cough vaccine side effects are uncommon. Rarely, the intranasal ...
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Bordetella pertussis (incubation period of 1-3 weeks, fever is uncommon, suspect if cough persists for ,2 weeks){ref2}: First- ... Bordetella pertussis (incubation period of 1-3 weeks, fever is uncommon, suspect if cough persists for ,2 weeks) [2] :. * First ... encoded search term (What are the organism-specific therapeutic regimens for Bordetella pertussis bronchitis?) and What are the ... What are the organism-specific therapeutic regimens for Bordetella pertussis bronchitis?. Updated: Aug 20, 2019 ...
Recently, the Petfinder.com Foundation awarded six Petfinder shelters and rescue groups bordetella ... Bordetella is commonly known as kennel cough, and spreads rapidly among shelter populations. "Shelters are often compelled by ... "Being able to vaccinate against bordetella will add another positive. step we are taking to ensure our animals are healthy and ... The Petfinder.com Foundation gives six shelters bordetella vaccination grants. by Lisa, Petfinder Foundation executive director ...
Bordetella bronchiseptica ATCC ® 10580™ Designation: 03127 TypeStrain=False Application: Media testing Quality control strain ... Bordetella bronchiseptica (Ferry) Moreno-Lopez (ATCC® 10580™) Strain Designations: 03127 / Type Strain: no / Biosafety Level: 2 ...
Bordetella bronchiseptica ATCC ® 4617™ Designation: NRRL B-140 TypeStrain=False Application: Assay of colistimethate sodium ... Bordetella bronchiseptica (Ferry) Moreno-Lopez (ATCC® 4617™) Strain Designations: NRRL B-140 / Type Strain: no / Biosafety ...
Bordetella pertussis causes whooping cough, a severe respiratory tract infection in infants and children, and also infects ... Immunity to the respiratory pathogen Bordetella pertussis Mucosal Immunol. 2012 Sep;5(5):485-500. doi: 10.1038/mi.2012.54. Epub ... Bordetella pertussis causes whooping cough, a severe respiratory tract infection in infants and children, and also infects ...
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  • Recently, the Petfinder.com Foundation awarded six Petfinder shelters and rescue groups bordetella vaccination grants totaling more than $64,000. (petfinder.com)
  • With intranasal and oral versions of the Bordetella shot, one vaccination may be adequate, followed by yearly boosters. (embracepetinsurance.com)
  • Bordetella pertussis is the gram-negative coccobacil- doses of ACV at 2, 4, and 6 months of age, and a booster lus that causes the respiratory disease pertussis, also vaccination at 4 years of age. (cdc.gov)
  • Bordetella vaccination? (guinealynx.info)
  • World-renowned vaccination scientist, Dr. Ronald Schultz , says [emphasis mine]: "Many animals receive "kennel cough" vaccines that include Bordetella and CPI and/or CAV-2 every 6 to 9 months without evidence that this frequency of vaccination is necessary or beneficial. (dogs4dogs.com)
  • While not considered to be core, Bordetella vaccination may be recommended for dogs whose lifestyle places them at greater risk of contracting the disease. (vetstreet.com)
  • Vaccination can protect your dog from illness associated with Bordetella. (vetstreet.com)
  • Vaccination can protect your dog from illness associated with Bordetella, particularly if your dog frequents kennels, groomers, dog shows, or dog sporting events. (vetstreet.com)
  • Despite high vaccination coverage, Bordetella pertussis the causative agent of whooping cough is still a health concern worldwide. (medworm.com)
  • Bordetella species, with the exception of B. petrii, are obligate aerobes, as well as highly fastidious, or difficult to culture. (wikipedia.org)
  • The most thoroughly studied of the Bordetella species are B. bronchiseptica, B. pertussis and B. parapertussis, and the pathogenesis of respiratory disease caused by these bacteria has been reviewed. (wikipedia.org)
  • The three most common species of Bordetella are B. pertussis, B. parapertussis and B. bronchiseptica. (wikipedia.org)
  • Due to the fact B. pertussis is only found in humans and shows little genetic variation form the other Bordetella species, it is thought that it was derived from a common ancestor in recent years. (wikipedia.org)
  • The virulence factors identified in the bordetella are common to all three species. (wikipedia.org)
  • New Species of Bordetella , Bordetella ansorpii sp. (asm.org)
  • The respiratory quinone, polar lipid and fatty acid profiles generally conformed to those of species of the genus Bordetella and were characterized by the presence of ubiquinone 8, of phosphatidylethanolamine, phosphatidylglycerol, diphosphatidylglycerol and several aminolipids, and of high percentages of C-16 : 0, cyclo-C-17 : 0 and summed feature 2, as major chemotaxonomic marker molecules, respectively. (gu.se)
  • It is believed that the species diverged 3.5 million years ago through decay of the Bordetella brochiseptica genome, as seen through a large-scale gene loss of the two subsequent species. (kenyon.edu)
  • The ARIES® Bordetella Assay (RUO) is a rapid, accurate method for the detection and differentiation of two key Bordetella species. (luminexcorp.com)
  • A total of 303 isolates of Bordetella bronchiseptica recovered from 11 host species were characterized by the electrophoretic mobilities of 15 metabolic enzymes, and 21 distinctive multilocus genotypes (electrophoretic types) were distinguished on the basis of allele profiles at the enzyme loci. (asm.org)
  • A species of BORDETELLA that is parasitic and pathogenic. (ki.se)
  • By real-time PCR targeting of IS481, Bordetella DNA was detected in nasopharyngeal swab (NPS) specimens (1), but the species could not be identified because of an insufficient amount of DNA. (thefreelibrary.com)
  • The Bordetella genus contains at the moment a dozen species, of which at least five are responsible for respiratory diseases in humans and/or animals. (mdpi.com)
  • JCVI: Acquisition and Loss of Virulence-associated Factors During Genome Evolution and Speciation in Three Clades of Bordetella Species. (jcvi.org)
  • The genus Bordetella consists of nine species that include important respiratory pathogens such as the 'classical' species B. bronchiseptica, B. pertussis and B. parapertussis and six more distantly related and less extensively studied species. (jcvi.org)
  • This strict aerobe is motile by peritrichous flagella and is capable of growing rapidly at 35 o C to 37 o C Footnote 4 , Footnote 5 and is relatively simple in its nutritional requirements as compared to other Bordetella species Footnote 5 . (canada.ca)
  • 4,9] Bordetella bronchiseptica is mostly closely related to Bordetella pertussis and Bordetella parapertussis, both of which is believed to have risen originally from Bordtella bronchiseptica. (kenyon.edu)
  • It is not contagious to humans though it is closely related to Bordetella pertussis, the agent of Whooping Cough. (guinealynx.info)
  • It is related to Bordetella pertussis, the obligate human pathogen, that causes pertussis or whooping cough. (sciencephoto.com)
  • Bordetella is a genus of small (0.2 - 0.7 µm), Gram-negative coccobacilli of the phylum Proteobacteria. (wikipedia.org)
  • The Bordetella genus is named after Jules Bordet. (wikipedia.org)
  • Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus of the genus Bordetella, and the causative agent of pertussis or whooping cough. (wikipedia.org)
  • Any of various small, gram-negative coccobacilli of the genus Bordetella, some of which are pathogenic in the human respiratory tract. (yourdictionary.com)
  • In a 16S rRNA gene sequence based phylogenetic tree, the four strains consistently formed a single coherent lineage but their assignment to the genus Bordetella was equivocal. (gu.se)
  • The DNA G+C content was about 66 mol%, which corresponded with that of the high-percentage DNA G+C content genera of the family Alcaligenaceae including the genus Bordetella. (gu.se)
  • The organism would go through at least four more name changes before Moreno-Lopez founded and described the genus Bordetella (After the first man to isolate the pertussis-causing organism, Jules Bordet). (kenyon.edu)
  • While its genome does encode complete pathways for biosynthesis of needed intermediates, Bordetella bronchiseptica and the genus Bordetella in general do not use sugars as a carbon source. (kenyon.edu)
  • Bordetella avium: an opportunistic pathogen in leghorn chickens. (cabi.org)
  • In the 2 experiments, groups of young commercial turkeys and SPF chickens, respectively, were challenged at 2 weeks of age with one of 7 different isolates of Bordetella avium and 2 isolates of B. avium -like bacteria. (cabi.org)
  • Like all vaccines, Bordetella works by injecting a small amount of the bacteria or virus into the bloodstream of the animal. (howstuffworks.com)
  • Sometimes Bordetella vaccines are combined with parainfluenza virus vaccines to protect dogs for multiple types of respiratory tract infections at the same time. (embracepetinsurance.com)
  • Bordetella vaccines can be given by mouth (i.e. orally), in the nose (i.e. intranasally), or as an injection under the skin (i.e. subcutaneously). (embracepetinsurance.com)
  • Acellular vaccines against Bordetella pertussis were implementation of immunization with a whole-cell vaccine introduced in Australia in 1997. (cdc.gov)
  • The injectable bordetella in a series of two vaccines, given 2 to 4 weeks apart then given annually. (vetinfo.com)
  • Other vaccines, such as the rabies and Bordetella vaccines, may be given in addition to the canine distemper/parvo combination vaccine. (vetstreet.com)
  • IMPORTANCE Whooping cough, primarily caused by Bordetella pertussis , has resurged in the United States even though the coverage with pertussis-containing vaccines remains high. (pubmedcentralcanada.ca)
  • The vaccine manufacturers claim one year duration for many of the bordetella vaccines but other studies don't support this claim. (dogs4dogs.com)
  • Whole cell pertussis vaccines (Pw) induce Th1 responses and protect against Bordetella pertussis infection, whereas pertussis acellular vaccines (Pa) induce Ab and Th2-biased responses and also protect against severe disease. (jimmunol.org)
  • However, Pw have been associated with a number of local and systemic reactions, and although still used in developing countries, have been replaced in developed countries by acellular pertussis vaccines (Pa), prepared with highly purified Ags from Bordetella pertussis administered with alum as the adjuvant ( 1 , 2 ). (jimmunol.org)
  • The Sanger Institute has completed a project to sequence further strains within the Bordetella bronchiseptica complex to investigate the evolutionary history and host tropism differences within this group of organsims. (sanger.ac.uk)
  • The phenotypic and genotypic characteristics of four Bordetella hinzii-like strains from human respiratory specimens and representing nrdA gene sequence based genogroups 3, 14 and 15 were examined. (gu.se)
  • Bordetella pertussis, the main causative agent of whooping cough, is a reemerging pathogen, and recent vaccine-resistant strain outbreaks and emergence of macrolides-resistant strains in China raised new concerns for control of the disease. (medworm.com)
  • Southern blot analysis indicates that strains of Bordetella bronchiseptica and Bordetella parapertussis have DNA homologous to vag-8 . (asm.org)
  • Strains of Bordetella were grown on Bordet-Gengou (BG) medium supplemented with 12% sheep blood or in cyclodextrin solid medium (CSM) ( 1 ). (asm.org)
  • Other bacteria recycle this molecule back into the cytoplasm, but in Bordetella and Neisseria gonorrhoeae, it is released into the environment. (wikipedia.org)
  • Bordetella bronchiseptica is the primary bacteria associated with kennel cough (i.e. infectious tracheobronchitis) in dogs. (embracepetinsurance.com)
  • La tos ferina es una enfermedad del tracto respiratorio que se presenta exclusivamente en los seres humanos y es causada por la bacteria gramnegativa Bordetella pertusis. (prezi.com)
  • False colour transmission electron micrograph (TEM) of a thin section of the whooping cough bacteria, Bordetella pertussis. (sciencephoto.com)
  • The pathogenic bacteria Bordetella parapertussis and Bordetella bronchiseptica express a lipopolysaccharide O antigen containing a polymer of 2,3-diacetamido-2,3-dideoxy-l-galacturonic acid. (rcsb.org)
  • Here, we developed a scalable, rapid, high-throughput luminescence-based Bordetella growth inhibition assay (BGIA) to quantify surviving bacteria after treatment with anti-B. pertussis compounds. (medworm.com)
  • Bordetella bronchiseptica is an easily contracted bacteria that causes a hacking cough or, occasionally, a snotty nose. (vetstreet.com)
  • Bordetella bronchiseptica is one of several organisms included on a short list of bacteria and viruses responsible for this kennel cough syndrome. (vetstreet.com)
  • Mike Richards, DVM 12/7/02: "On the differing recommendations among vets for bordetella (and probably the other viruses and bacteria) - to some extent recommendations are based on who the vet believes. (dogs4dogs.com)
  • Whooping cough is a disease of the respiratory tracts which is caused by Bordetella pertussis bacteria. (rapidtest.com)
  • Bordetella pertussis causes whooping cough, a severe respiratory tract infection in infants and children, and also infects adults. (nih.gov)
  • Kennel cough can also be caused by a bacterial infection, like bordetella bronchiseptica. (vetinfo.com)
  • The injectable bordetella offers systemic immunity but does not provide local immunity for the respiratory tract where the infection is occurring. (vetinfo.com)
  • Bordetella infection can be picked up by rabbits, guinea pigs, pigs, cats (if they are very young and housed in groups), and other dogs. (guinealynx.info)
  • Neither vaccine will totally prevent infection with Bordetella. (ocpetinfo.com)
  • A persistent honking, hacking, and/or gagging cough is typical of Bordetella infection. (vetstreet.com)
  • Immunization with the Recombinant Cholera Toxin B Fused to Fimbria 2 Protein Protects against Bordetella pertussis Infection. (biomedsearch.com)
  • This study examined the immunogenic properties of the fusion protein fimbria 2 of Bordetella pertussis (Fim2)-cholera toxin B subunit (CTB) in the intranasal murine model of infection. (biomedsearch.com)
  • The data presented here provide support for CTB-Fim2 as a promising recombinant antigen against Bordetella pertussis infection. (biomedsearch.com)
  • Pertussis is an acute respiratory infection caused by Bordetella pertussis . (pubmedcentralcanada.ca)
  • It is caused by the bacterium Bordetella pertussis . (cdc.gov)
  • Bordetella bronchiseptica is a bacterium that causes respiratory disease in dogs. (vetstreet.com)
  • Bordetella bronchiseptica is a bacterium that is commonly associated with respiratory disease in dogs. (vetstreet.com)
  • The purified lymphocytosis promoting factor (LPF) from Bordetella pertussis was found to be a potent mitogen for peripheral blood lymphocytes (PBL) from normal adults as well as for cord blood lymphocytes. (eurekamag.com)
  • The in vitro effects of Bordetella pertussis lymphocytosis-promoting factor on murine lymphocytes. (rupress.org)
  • The mitogenic response of murine lymphocytes to the lymphocytosis-promoting factor of Bordetella pertussis has been shown to be due to activation of T cells. (rupress.org)
  • Nearly all virulence factors in Bordetella pertussis are activated by a master two-component system, BvgAS, composed of the sensor kinase BvgS and the response regulator BvgA. (asm.org)
  • 2020 Sep 28;137:155313 Authors: da Silva Antunes R, Quiambao LG, Soldevila F, Sutherland A, Peters B, Sette A Abstract Bordetella Pertussis (BP) vaccine-induced immunity is waning worldwide despite excellent vaccine coverage. (medworm.com)
  • Difco Bordetella Pertussis Antigen is used to demonstrate a positive quality control test in the slide agglutination test. (spectrumchemical.com)
  • The effect of an i.p. injection of Bordetella pertussis on the primary humoral immune response in mice to the thymus-independent antigen SIII has been studied. (jimmunol.org)
  • Bordetella antigen is bound on the surface of the microtiter strips. (rapidtest.com)
  • A binding between the IgA antibodies of the serum and the immobilized Bordetella antigen takes place. (rapidtest.com)
  • Bacteremia due to Bordetella holmesii. (nih.gov)
  • Recurrent Bordetella holmesii bacteremia and nasal carriage in a patient receiving Rituximab. (thefreelibrary.com)
  • To the Editor: We report a case of recurrent Bordetella holmesii bacteremia with 4 clinical manifestations: 3 episodes of cellulitis and 1 episode of pneumonia. (thefreelibrary.com)
  • Bordetella holmesii can cause invasive infections but can also be isolated from the respiratory tract of patients with whooping-cough like symptoms. (mdpi.com)
  • Abcam's anti-Bordetella pertussis IgG Human in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the accurate qualitative measurement of IgG class antibodies against Bordetella pertussis in Human serum and plasma. (abcam.com)
  • The Diagnostic Automation Bordetella pertussis IgA Antibody ELISA Test Kit has been designed for the detection and the quantitative determination of specific IgA antibodies against Bordetella pertussis in serum and plasma. (rapidtest.com)
  • Adenylate cyclase-hemolysin toxin (CyaA) produced from the human respiratory tract pathogen Bordetella pertussis requires fatty-acyl modification by CyaC-acyltransferase to become an active toxin. (sigmaaldrich.com)
  • High prevalence of pertactin (PRN)-deficient Bordetella pertussis isolates has been found in these countries. (eurosurveillance.org)
  • Although Bordetella pertussis is well known for its limited gene sequence variation, recent advances in long-read sequencing technology have begun to reveal genomic structural heterogeneity among otherwise indistinguishable isolates, even within geographically or temporally defined epidemics. (pubmedcentralcanada.ca)
  • Bordetella pertussis is the causative agent of the disease whooping cough. (asm.org)
  • Bordetella pertussis is the causative agent of whooping cough (pertussis), a respiratory disease with the highest morbidity and mortality in young infants. (pubmedcentralcanada.ca)
  • Kennel cough, also known as canine infectious tracheobronchitis, is a highly contagious disease that can be prevented with the bordetella vaccine for dogs . (vetinfo.com)
  • Bordetella is highly contagious, easily transmitted through direct contact or the air, and resistant to destruction in the environment. (vetstreet.com)
  • Whooping cough is a highly contagious disease that is caused by the fastidious Gram-negative coccobacillus Bordetella pertussis . (cmft.nhs.uk)
  • Bordetella bronchiseptica is a minute, gram-negative rod-shaped coccobacilli about .5-1 micrometers in diameter and 5 micrometers in length. (kenyon.edu)
  • Limited Applicability of Direct Fluorescent-Antibody Testing for Bordetella sp. (asm.org)
  • The heterohybridoma cell line HBp2 secreting human monoclonal antibody (hMAb) directed against Bordetella pertussis was generated by fusing SP2/HPT heteromyeloma cells with human spleen lymphocytes, after in vitro stimulation for 6 days. (nih.gov)
  • Difco ™ FA Bordetella Pertussis and Difco FA Bordetella Parapertussis are recommended for use in the direct fluorescent antibody technique for the identification of Bordetella pertussis and Bordetella parapertussis. (spectrumchemical.com)
  • The Diagnostic Automation Bordetella pertussis IgA antibody test kit is based on the principle of the enzyme immunoassay (EIA). (rapidtest.com)
  • Helical structure of Bordetella pertussis fimbriae. (asm.org)
  • The helical structures of Bordetella pertussis fimbriae of serotypes 2 and 6 were determined by optical diffraction analysis of electron micrographs of negatively stained paracrystalline bundles of purified fimbriae. (asm.org)
  • The efficacy of a whole cell pertussis vaccine and fimbriae against Bordetella pertussis and Bordetella parapertussis infections in a respiratory mouse model. (rivm.nl)
  • It has also had its genome sequenced, primarily to derive data in comparison to its relative Bordetella pertussis, which causes whooping cough in humans. (kenyon.edu)
  • Bordetella pertussis was isolated from a patient with whooping cough. (thelabrat.com)
  • Bordetella pertussis, the human pathogen of whooping cough, when grown at 22 degrees C is nonvirulent and unable to bind eukaryotic cells. (pnas.org)
  • The Sanger Institute has been funded by the Wellcome Trust to sequence the genomes of Bordetella pertussis strain Tohama I, B. parapertussis strain 12822 and B. bronchiseptica strain RB50 in collaboration with Duncan Maskell and Andrew Preston of the Centre for Veterinary Science, Dept. of Clinical Veterinary medicine, The University of Cambridge. (sanger.ac.uk)
  • Most dogs probably prefer the nasal version of the Bordetella vaccine to the sting of the needle. (howstuffworks.com)
  • There are two different forms of the bordetella vaccine: the injectable form and the intra nasal form. (vetinfo.com)
  • The Aries Bordetella assay (Aries BA) (Luminex Corporation) recently received FDA clearance for the detection and differentiation of Bordetella pertussis and Bordetella parapertussis nucleic acids in nasopharyngeal swab (NPS) samples. (asm.org)
  • Detection and Differentiation of Bordetella spp. (asm.org)
  • How often Bordetella vaccine is given depends a little on your pet's risk. (embracepetinsurance.com)
  • The bordetella vaccine is given to your dog to help decrease the intensity of the disease if he is exposed to kennel cough. (vetinfo.com)
  • The sequences and analysis are described in: Parkhill et al (2003) Comparative analysis of the genome sequences of Bordetella pertussis , Bordetella parapertussis and Bordetella bronchiseptica . (sanger.ac.uk)
  • The activities of our team are focused on two bacterial pathogens of the respiratory tract, Mycobacterium tuberculosis and Bordetella pertussis , responsible for tuberculosis and pertussis, respectively. (pasteur-lille.fr)
  • Bordetella flabilis sp nov and Bordetella sputigena sp nov., isolated from human respiratory specimens, and reclassification of Achromobacter sediminum Zhang et al. (gu.se)
  • Thus, Vag8 becomes the fourth member of this Bordetella family of proteins to be identified. (asm.org)
  • Just did a bit of research Googling Bordetella, and it seems like your pig should have been showing signs of illness before she died. (guinealynx.info)
  • Bordetella isn't even a common illness amoung guinea pigs. (guinealynx.info)
  • In healthy adult dogs, Bordetella usually causes no more than a mild, self-limiting illness. (vetstreet.com)
  • Cost of Bordetella pertussis illness in tertiary hospitals in Argentina. (scielo.org.ar)
  • Bordetella Bronchiseptica Intranasal Vaccine. (howstuffworks.com)
  • Nobivac Feline-Bb is an intranasal vaccine containing an avirulent live culture of Bordetella bronchiseptica. (medi-vet.com)
  • Human infections associated with Bordetella bronchiseptica. (asm.org)
  • getshelly, I just did a search of bordetella with pinta as the author (posts not topics) and a lot of stuff came up if you want to read about it. (guinealynx.info)
  • There is an injectable Bordetella vaccine, and one that is given intranasally (squirted into the nostrils). (ocpetinfo.com)
  • If the person insisting on the bordetella vaccine is afraid other dogs at their establishment will contract kennel cough from your un vaccinated dog, this person clearly doesn't trust that the vaccinated dogs actually have immunity. (dogs4dogs.com)
  • Your puppy should receive their first Bordetella vaccinations at 8 weeks of age and then boostered in 3-4 weeks for full immunity. (dogandcat.com)