Boranes
Boron
Boron Compounds
Phosphines
Boron Neutron Capture Therapy
Stereoisomerism
Mammalian nitric oxide synthases. (1/130)
The nitric oxide (NO) synthase family of enzymes generate NO from L-arginine, which acts as a biologic effector molecule in a broad number of settings. This report summarizes some of the current information regarding NO synthase structure-function, reaction mechanism, control of catalysis, and protein interactions. (+info)[3H]diborane reduction of vitamin K-dependent calcium-binding proteins. Identification of a unique amino acid. (2/130)
gamma-Carboxyglutamic acid has recently been identified as a component of the vitamin K-dependent region of bovine prothrombin (Nelsestuen, G. L., Zytkovicz, T. H., and Howard J. B. (1974) J. Biol Chem. 249, 6347-6350). The presence of this amino acid has been substantiated here by the reduction of vitamin K-dependent proteins with [3H]-DIBORANE. The reduction product of gamma-carboxyglutamic acid, 5,5'-[3H]dihydroxyleucine, was shown to be present in hydrolysates of reduced rat prothrombin, bovine prothrombin, and bovine factor X. The results are consistent with a minimum of 10 gamma-carboxyglutamic acid residues in the nonthrombin-generating region of bovine prothrombin but no such residues in the thrombin precursor portion of prothrombin. It is concluded that amino acid analyses of [3H]diborane-reduced proteins provides a sensitive, qualitative method for the identification of proteins which contain gamma-carboxyglutamic acid and are vitamin K-dependent. (+info)Alpha-glucosidase inhibitors with a 4,5,6,7-tetrachlorophthalimide skeleton pendanted with a cycloalkyl or dicarba-closo-dodecaborane group. (3/130)
Previous studies of alpha-glucosidase inhibitors derived from thalidomide revealed that 4,5,6,7-tetrachloro-N-alkylphthalimide derivatives are superior lead compounds. Structure-activity relationship studies indicated that a hydrophobic group at the N(2) position is mandatory for potent activity. Accordingly, we have designed and synthesized some 4,5,6,7-tetrachloro-N-cycloalkylphthalimide and 4,5,6,7-tetrachloro-N-dicarba-closo-dodecaborane derivatives. The prepared compounds exhibited potent alpha-glucosidase-inhibitory activity. Among them, 4,5,6,7-tetrachloro-N-cycloheptylphthalimide (9) showed the most potent activity, being approximately 30 times more active than the classical inhibitor, 1-deoxynojirimycin (1). (+info)A synthesis of 3-phenyl-1,2,3,4-tetrahydroisoquinoline and 2-phenyl-1,2,4,5-tetrahydro-3H-3-benzazepine via Pummerer-type cyclization: enhancing effect of boron trifluoride diethyl etherate on the cyclization. (4/130)
A synthesis of 6,7-dimethoxy-3-phenyl-1,2,3,4-tetrahydroisoquinoline (14a) and 7,8-dimethoxy-2-phenyl-1,2,4,5-tetrahydro-3H-3-benzazepine (14b) was achieved via the cyclization of N-(3,4-dimethoxyphenyl)methyl-1-phenyl-2-(phenylsulfinyl)ethylformamide (6a) and N-2-(3,4-dimethoxyphenyl)ethyl-1-phenyl-2-(phenylsulfinyl)-ethylformamide (6b) using the Pummerer reaction as a key step, respectively. The Pummerer reaction of 6a,b under usual conditions using trifluoroacetic anhydride yielded the vinyl sulfides (8a, b), non-cyclized products, as a major product. The cyclization proceeded when boron trifluoride diethyl etherate was used as an additive reagent, thus giving rise to the corresponding cyclized products (7a) and (7b) in moderate yields. We propose that the enhancing effect of the Lewis acid on the cyclization may be attributable to the involvement of a dicationic intermediate, sulfonium-carbenium dication (23). (+info)In vitro antimycobacterial activities of 2'-monosubstituted isonicotinohydrazides and their cyanoborane adducts. (5/130)
As a result of our search for new isoniazid derivatives with extended spectra of activity, we evaluated the in vitro antimycobacterial activities of isonicotinohydrazides (compounds 2) and their cyanoborane adducts (compounds 3), both obtained by the reaction of isonicotinoylhydrazones (compounds 1) with sodium cyanoborohydride. Most of the tested compounds displayed moderate to high activity against Mycobacterium tuberculosis H37Rv, with MICs ranging from 0.2 to 12.5 microg/ml. In particular, some hydrazides showed activity similar to that of rifampin (MIC = 0.2 microg/ml) and rather low cytotoxicity, so that they were generally shown to possess high safety indices. In contrast, the coordination to a cyanoborane (BH(2)CN) group (compounds 3) in general brought about a decrease in antimycobacterial activity, while cytotoxicity increased. Interestingly, selected compounds 1 to 3, mostly hydrazides (compounds 2), were effective in killing M. tuberculosis growing within macrophages at concentrations in culture medium which were much lower than the corresponding MICs. These compounds also displayed good activity against drug-resistant M. tuberculosis strains. (+info)Convection-enhanced delivery of boronated epidermal growth factor for molecular targeting of EGF receptor-positive gliomas. (6/130)
Convection enhanced delivery (CED) is potentially a powerful method to improvethe targeting of macromolecules to the central nervous system by applying a pressure gradient to establish bulk flow through the brain interstitium during infusion. The purpose of the present study was to evaluate CED as a means to improve the intracerebral and intratumoral (i.t.) uptake of a heavily boronated macromolecule (dendrimer; BD) linked to epidermal growth factor (EGF) for neutron capture therapy in rats bearing a syngeneic epidermal growth factor receptor (EGFR) + glioma. Boronated EGF was radiolabeled with 125I and administered by CED at a rate of 0.33 micro l/min for 15, 30, and 60 min [infusion volumes (V(I)) of 5, 10, and 20 micro l, respectively], using a syringe pump connected to an indwelling cannula implanted into the right caudate nucleus of normal rats or i.t. in rats bearing either F98(EGFR) or F98 wild-type (F98(WT)) gliomas. After infusion, rats were euthanized, and their brains were removed and serially sectioned. The uptake and biodistribution of (125)I-boronated EGF in tumor or brain was studied by quantitative autoradiography and gamma-scintillation counting. The volume of distribution (V(d)) in brain was assessed using a computer interfaced image analysis system. After CED, the V(d) increased from 34.4 to 123.5 micro l with corresponding V(i) ranging from 5 to 20 micro l. The V(d) of BD-EGF in the brain was 64.8 +/- 13.4 micro l with CED (V(i) 10 micro ), and the V(d):V(i) ratio was 6.5 compared with a V(d) of 9.4 +/- 1.6 micro l and a V(d):V(i) ratio of 0.9 after direct intracerebral injection. As determined by quantitative autoradiography and gamma-scintillation counting at 24 h after CED, 47.4% of the injected dose per gram tissue (%ID/g) was localized in F98(EGFR) gliomas compared with 33.2%ID/g after direct i.t. injection and 12.3%ID/g in F98(WT) gliomas. On the basis of these observations, we have concluded that CED is more effective than i.t. injection as a way to deliver boronated EGF to EGFR (+) gliomas for boron neutron capture therapy. (+info)Asymmetric borane reduction of prochiral ketone using chiral bis(alpha, alpha-diphenyl-2-pyrrolidinemethanol) carbonate. (7/130)
Chiral bis(alpha, alpha-diphenyl-2-pyrrolidinemethanol) carbonate (DPP(2).H(2)CO(3)) is a useful asymmetric auxiliary for the asymmetric borane reduction of prochiral ketones. Chiral DPP(2).H(2)CO(3) is recoverable from the reaction and directly reusable for the reaction. The intermediate of KUR-1246, which we are developing as a new uterine relaxant, was synthesized using the methodology. (+info)Diastereoselective solid-phase radical addition to oxime ether anchored to polymer support. (8/130)
Stereocontrol in radical reactions of oxime ether anchored to polymer support was studied. Highly diastereoselective solid-phase radical reaction was achieved by using triethylborane and diethylzinc as a radical initiator at low reaction temperature, providing a novel method for the synthesis of the alpha-amino acid derivatives with excellent diastereoselectivities. (+info)Boranes are compounds containing boron-boron bonds, and some of them have potential medical applications such as in cancer treatment.
I'm sorry, but I couldn't find any information on the use of the term "Boranes" in the medical field. It's possible that you may have misspelled the term or that it is not commonly used in this context. Boranes are a group of compounds that contain boron atoms bonded to hydrogen atoms. They are typically used in chemical reactions and have a wide range of applications in various fields, including materials science, electronics, and medicine. However, I couldn't find any specific medical applications of boranes. If you have any additional information or context about the term "Boranes" in the medical field, please let me know and I'll do my best to provide a more accurate answer.
Boron is a trace element that has potential medicinal applications, including as a dietary supplement for improving bone health and as a component in some cancer treatments.
Boron is a chemical element that is not typically used in the medical field for therapeutic purposes. However, boron has been studied for its potential health benefits and its role in various biological processes. In some cases, boron supplements are marketed for their potential to support bone health, improve athletic performance, and reduce menopausal symptoms. However, the evidence for these claims is limited and more research is needed to confirm their effectiveness and safety. Boron is also used in certain medical treatments, such as neutron capture therapy, which involves using boron-10 to target and destroy cancer cells. In this treatment, boron-10 is selectively taken up by cancer cells and then bombarded with neutrons, which causes the boron-10 to capture the neutrons and release high-energy particles that destroy the cancer cells. Overall, while boron has some potential health benefits and is used in certain medical treatments, more research is needed to fully understand its role in the body and its potential therapeutic applications.
Boron compounds are a class of molecules that contain boron atoms, and some of them have potential medical applications such as in cancer treatment and bone health.
In the medical field, boron compounds refer to chemical compounds that contain boron as a central atom. Boron is an essential trace element for human health, and some boron compounds have been studied for their potential therapeutic effects in various diseases. One of the most well-known boron compounds in medicine is boron neutron capture therapy (BNCT), which involves the use of boron-labeled compounds to target cancer cells and then exposing them to neutrons. The boron atoms in the cancer cells absorb the neutrons and undergo nuclear reactions that release high-energy particles that can destroy the cancer cells while sparing healthy tissue. Other boron compounds that have been studied in medicine include boron hydride complexes, which have been used as potential treatments for certain types of cancer, and boron-containing drugs, which have been investigated for their potential to treat osteoporosis and other bone diseases. Overall, boron compounds have shown promise as potential therapeutic agents in medicine, but more research is needed to fully understand their mechanisms of action and potential side effects.
Borates are a class of minerals and salts that contain boron, which has been used in the medical field for various therapeutic purposes, including as an antiseptic, anti-inflammatory, and treatment for certain skin conditions.
Borates are a group of minerals that contain boron, a chemical element with the symbol B and atomic number 5. Borates are used in a variety of applications in the medical field, including as antiseptics, disinfectants, and as components in some medications. One common use of borates in medicine is as a topical antiseptic. Boric acid, a common borate mineral, has been used for centuries as a natural antiseptic and. It is often used in over-the-counter products such as vaginal suppositories and eye drops to treat infections and other conditions. Borates are also used in some medications as a component to help with the absorption of other active ingredients. For example, boric acid is used in some oral contraceptives to help with the absorption of hormones. In addition to their use in medicine, borates are also used in other industries, such as agriculture and cosmetics, due to their unique properties, such as their ability to absorb moisture and their ability to act as a mild abrasive.
Phosphines are a class of chemical compounds that contain a phosphorus atom covalently bonded to one or more hydrogen atoms, and have potential applications in medicine as ligands for metal ions in drug design and as inhibitors of enzymes involved in disease processes.
Phosphines are a class of chemical compounds that contain a central phosphorus atom bonded to one or more hydrogen atoms and one or more other atoms or groups. They are not typically used in the medical field, as they are primarily used in industrial and laboratory settings for a variety of applications, such as in the production of pharmaceuticals, agrochemicals, and electronic materials. However, there are some exceptions. For example, some phosphines have been studied for their potential use as drugs to treat certain medical conditions. These compounds are thought to work by binding to specific proteins or enzymes in the body, which can alter their activity and potentially have therapeutic effects. However, more research is needed to fully understand the potential uses and safety of these compounds in the medical field.
Amino alcohols are a class of organic compounds that contain both an amino group and an alcohol group, and have potential medical applications as drugs or drug precursors.
Amino alcohols are a class of organic compounds that contain both an amino group (-NH2) and an alcohol group (-OH) attached to the same carbon atom. They are commonly found in nature and have a wide range of biological activities, including antimicrobial, antiviral, and anticancer properties. In the medical field, amino alcohols are used as drugs and as intermediates in the synthesis of other drugs. For example, the amino alcohol chloroquine is used to treat malaria, while the amino alcohol amantadine is used to treat influenza. Other amino alcohols, such as proline and hydroxyproline, are important components of collagen, a protein that is essential for the structure and function of connective tissue in the body. Amino alcohols can also be used as precursors for the synthesis of other compounds, such as amino acids and peptides. They are also used in the production of detergents, surfactants, and other industrial chemicals.
Boron Neutron Capture Therapy is a cancer treatment that uses a boron-containing compound to preferentially absorb neutrons, leading to the destruction of cancer cells while minimizing damage to surrounding healthy tissue.
Boron Neutron Capture Therapy (BNCT) is a type of radiation therapy used to treat certain types of cancer. It works by targeting cancer cells with a small amount of a radioactive isotope called boron-10, which is selectively taken up by the cancer cells. When the boron-10 is bombarded with low-energy neutrons, it undergoes a nuclear reaction that releases high-energy alpha particles and lithium ions. These particles are highly damaging to cancer cells and can destroy them while leaving healthy cells relatively unharmed. BNCT is typically used to treat cancers that are difficult to treat with other forms of radiation therapy, such as glioblastoma multiforme (a type of brain cancer) and melanoma (a type of skin cancer). It is also being studied for the treatment of other types of cancer, such as head and neck cancer, breast cancer, and prostate cancer. To undergo BNCT, patients are first given a solution containing boron-10. They are then exposed to a beam of neutrons, which causes the boron-10 to undergo the nuclear reaction and release the high-energy particles. The treatment is typically performed in a medical facility equipped with a neutron source, such as a nuclear reactor or a particle accelerator.
Ethers are a class of organic compounds containing an oxygen atom bonded to two alkyl or aryl groups, with medical applications including anesthesia and as solvents for drugs.
In the medical field, ethers are a class of organic compounds that contain an oxygen atom bonded to two carbon atoms. They are commonly used as anesthetic agents, meaning they are used to induce a state of unconsciousness and analgesia (pain relief) during medical procedures. There are several different types of ethers, including diethyl ether, chloroform, and halothane. These compounds work by disrupting the normal functioning of the brain, leading to a loss of consciousness and pain relief. Ethers have been used as anesthetics for many years, but their use has declined in recent decades due to concerns about their potential side effects, including respiratory depression, nausea, and vomiting. However, they are still used in certain medical situations, such as in the treatment of certain types of cancer.
Boranes
A borane is a compound with the formula BxHy or a related anion. Many such boranes are known. Most common are those with 1 to ... Hybrids of boranes and hydrocarbons, the carboranes are also well developed. The development of the chemistry of boranes led to ... For example, reaction of a borane cluster with B2H6 (as a source of BH3) can lead to the formation of a conjuncto-borane ... 10B + 1n → (11B*) → 4He + 7Li + γ (2.4 Mev) Category:Boranes, containing all specific borane-compound articles Sara Rietti, ...
Dehydrogenation of amine-boranes
... or dehydrocoupling of amine-boranes is a chemical process in main group and organometallic ... 5 rather than the typically seen cyclic dimers from other amine-borane dehydrogenations. When catalyzing ammonia-borane ... Secondary amine-boranes dehydrogenate to form cyclic dimers, or monomeric aminoboranes in the case of more bulky groups on the ... Ammonia borane has attracted particular interest due to its high weight percent of hydrogen (19.6%). Dehydrogenation occurs in ...
Borane
Phosphine-boranes, with the formula R3−nHnPBH3, are adducts of organophosphines and borane. Borane(5) is the dihydrogen complex ... Borane dimethylsulfide which is more stable than borane-tetrahydrofuran may also be used. Hydroboration can be coupled with ... Borane ammoniate, which is produced by a displacement reaction of other borane adducts, eliminates elemental hydrogen on ... Solutions containing borane dimethylsulfide and borane-tetrahydrofuran are commercially available; in tetrahydrofuran a ...
Borane carbonyl
... is the inorganic compound with the formula H3BCO. This colorless gas is the adduct of borane and carbon ... Borane carbonyl has an enthalpy of vaporization of 19.7 kJ/mol (4750 cal/mol). It has electronic state 1A1 and point group ... Borane carbonyl was discovered in 1937 by reacting diborane with excess carbon monoxide, with the equation: B2H6 + 2 CO ⇌ 2 ... The structure of the molecule of borane carbonyl is H3B−−C≡O+. The B−C≡O linkage is linear. The coordination geometry around ...
Alpine borane
R-Alpine-Borane and S-Alpine-Borane at Sigma-Aldrich M. M. Midland (1989). "Asymmetric reductions with organoborane reagents". ... Alpine borane is the commercial name for an organoboron compound that is used in organic synthesis. It is a colorless liquid, ... A range of alkyl-substituted borane are specialty reagents in organic synthesis. Two such reagents that are closely related to ... sterically crowded chiral trialkylborane can stereoselectively reduce aldehydes in what is known as the Midland Alpine borane ...
Phosphine-borane
... where the borane is often tris(pentafluorophenyl)borane Ammonia borane, related to phosphine-borane but with ammonia or amines ... Typically phosphine-boranes are produced by treating the parent phosphine with a source of borane: PR3−nHn + BH3 → R3−nHnPBH3 ... "Methyldiphenylphosphine-Borane and Dimethylphenylphosphine-Borane". Inorganic Syntheses. Inorganic Syntheses. Vol. 15. pp. 128- ... In chemistry, phosphine-boranes are organophosphorus compounds with the formula R3−nHnPBH3. They are Lewis acid-Lewis base ...
Borane-tetrahydrofuran
Ammonia borane Borane dimethylsulfide Borane tert-butylamine Marek Zaidlewicz, Herbert C. Brown, Santhosh F. Neelamkavil, " ... The use of borane-tetrahydrofuran has been displaced by borane-dimethylsulfide, which has a longer shelf life and effects ... Borane-tetrahydrofuran is an adduct derived from borane and tetrahydrofuran (THF). These solutions, which are colorless, are ... The following organoboron reagents are prepared from borane-THF: 9-borabicyclo[3.3.1]nonane, Alpine borane, ...
Ammonia borane
Phosphine-borane (R3P→BH3) borane dimethylsulfide (Me2S→BH3) borane-tetrahydrofuran (THF→BH3) Shore, S. G.; Boddeker, K. W. ( ... Borane trimethylamine (Me3N→BH3) Borane isopropylamine (iPrNH2→BH3) The first amine adduct of borane was derived from ... Ammonia borane is the main product when an adduct of borane is employed in place of diborane: BH3(THF) + NH3 → BH3NH3 + THF It ... Ammonia borane has been suggested as a storage medium for hydrogen, e.g. for when the gas is used to fuel motor vehicles. It ...
Borane dimethylsulfide
... (BMS) is a chemical compound with the chemical formula BH3·S(CH3)2. It is an adduct between borane ... The advantages of BMS over other borane reagents, such as borane-tetrahydrofuran, are its increased stability and higher ... Boranes add to alkenes in an anti-Markovnikov fashion and allow conversion of alkynes to the corresponding cis-alkenes. BMS has ... Borane dimethylsulfide is flammable and reacts readily with water to produce a flammable gas. It also has an unpleasant smell. ...
Tris(pentafluorophenyl)borane
... is a key reagent leading to the concept of frustrated Lewis pairs. The combination of BCF and ... Tris(pentafluorophenyl)borane, sometimes referred to as "BCF", is the chemical compound (C6F5)3B. It is a white, volatile solid ... Tris(pentafluorophenyl)borane is also capable of abstracting hydride to give [(C6F5)3BH]−, and it catalyzes hydrosilylation of ... Tris(pentafluorophenyl)borane is thermally stable at temperatures well over 200 °C, resistant to oxygen, and water-tolerant. ...
Borane tert-butylamine
... is an amine borane complex derived from tert-butylamine and borane. It is a colorless solid. The ... Ammonia borane Nöth, Heinrich; Beyer, Hasso; Vetter, Hans-Joanchim (1964). "Beiträge zur Chemie des Bors, XXV. Bis(amin)- ... borane tert-butylamine can be used for selective reduction of certain functional groups including aldehydes, ketones, oximes, ... "Tert-Butylamine borane". pubchem.ncbi.nlm.nih.gov. NCBI. Retrieved 3 September 2019. (Articles without InChI source, Articles ...
Midland Alpine borane reduction
The Alpine borane can be synthesized by refluxing alpha-pinene and 9-BBN in THF. While both enantiomers of alpine borane are ... The Midland Alpine borane reduction, or simply the Midland reduction, allows for the asymmetric reduction of carbonyls ( ... The stereochemical control comes from coordination of the bulky borane to the carbonyl, followed by hydride transfer opposite ...
Hydroboration-oxidation reaction
In order to prevent hydroboration across both the pi-bonds, a bulky borane like disiamyl (di-sec-iso-amyl) borane is used. Use ... In the first step, borane (BH3) adds to the double bond, transferring one of the hydrogen atoms to the carbon adjacent to the ... Alkyl migration to oxygen gives the alkyl borane with retention of stereochemistry (in reality, the reaction occurs via the ... Hawthorne, M. F. (1961). "Amine Boranes. VIII. The Hydroboration of Terminal Olefins, Dienes and Terminal Acetylenes with ...
Octadecaborane
Among the geometric isomers, one with chirality was the first borane to be resolved into its separate enantiomers, and was only ... Octadecaborane is an inorganic compound, a borane with chemical formula B18H22. It is a colorless flammable solid, like many ... Heřmánek, S.; Plešek, J. (1970). "Chemistry of boranes. XXI. Resolution of iso-octadecaborane to optical enantiomers". ... This compound was the first borane found to have multiple isomeric forms. ...
Methyldiborane
This will strip off borane to combine with the Lewis base, and let two methyl borane molecules dimerise. Methyldiborane can ... and can be imagined as methyl borane (CH3BH2) bound to borane (BH3). Other combinations of methylation occur on diborane, ... As with other boranes it exists in the form of a dimer with a twin hydrogen bridge that uses three-center two-electron bonding ... A gas chromatograph can be used to determine the amounts of the methyl boranes in a mixture. The order they pass through are ...
9-Borabicyclo(3.3.1)nonane
9-BBN is also known by its nickname 'banana borane'. This is because rather than drawing out the full structure, chemists often ... The steric demand of 9-BBN greatly suppresses the formation of the 2-substituted isomer compared to the use of borane. ... Organoboron chemistry Boron Brown, H. C. (1975). Organic Syntheses via Boranes. New York: John Wiley & Sons. ISBN 0-471-11280-1 ... 5-cyclooctadiene and borane usually in ethereal solvents, for example: The compound is commercially available as a solution in ...
Hydride
Brown, H. C. (1975). Organic Syntheses via Boranes. New York: John Wiley & Sons. ISBN 0-471-11280-1. Palladium hydride Züttel, ... borane, BH3 aluminium: alumane, AlH3 gallium: gallane, GaH3 indium: indigane, InH3 thallium: thallane, TlH3 carbon: alkanes, ... also borane, pentaborane and decaborane arsine: used for doping semiconductors stibine: used in semiconductor industry ...
1,2-Dimethyldiborane
Isadore Shapiro; C. O. Wilson; J. F. Ditter; W. J. Lehmann (1961). Borax to Boranes (PDF). Advances in Chemistry Series. Vol. ... More methylated boranes are less stable. 1,2-Dimethyldiborane slowly converts to 1,1-dimethyldiborane. Methylborane hydrolyzes ... By treating monomethyldiborane with ether, dimethyl ether borane (CH3)2O.BH3 leaving methylborane which rapidly dimerises to 1, ... by Borane: the Intimate Mechanism of an Alkyl Transfer Reaction". Journal of the American Chemical Society. 104 (9): 2361-2365 ...
List of inorganic compounds
"Borane". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-11-22. PubChem. "Borax". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-11-22. ... Bi2WO6 Borane - BH3 Borax - Na2B4O7·10H2O Borazine - B3H6N3 Borazocine ((3Z,5Z,7Z)-azaborocine) - B4H8N4 Boric acid - H3BO3 ...
Hydroboration
Borane adducts with phosphines and amines are also available, but are not widely used. Borane makes a strong adduct with ... This significant rate difference in producing di- and tri-alkyl boranes is useful in the synthesis of bulky boranes that can ... See Borane-dimethylsulfide complex Zaidlewicz, Marek; Baum, Ofir; Srebnik, Morris (2006). "Borane Dimethyl Sulfide". ... More sterically hindered tertiary and silyl amines can deliver borane to alkenes at room temperature. Monoalkyl boranes are ...
E. D. Jemmis
The latter involved an extension of the Wade's Rules for polyhedral boranes to macropolyhedral boranes and the Huckel 4n+2 Rule ... The Jemmis mno rules for polyhedral boranes have found a place in textbooks and are being taught in Inorganic Chemistry Courses ... Shameema, O.; Jemmis E. D. (2008). "Orbital Compatibility in the Condensation of Polyhedral Boranes". Angew. Chem. Int. Ed. 47 ... Jemmis, E. D.; Balakrishnarajan M. M. (2001). "Polyhedral Boranes and Elemental Boron: Direct Structural Relations and Diverse ...
Polyhedral skeletal electron pair theory
... the higher boranes and borane anions, and various transition-metal carbonyl cluster compounds". J. Chem. Soc. D. 1971 (15): 792 ... as is the case for many boranes and carboranes. For such clusters, the structures are based on deltahedra, which are polyhedra ... provides electron counting rules useful for predicting the structures of clusters such as borane and carborane clusters. The ... A Graph-Theoretical Interpretation of the Bonding Topology in Polyhedral Boranes, Carboranes, and Metal Clusters". J. Am. Chem ...
William Lipscomb
The Boranes and Their Relatives. in Les Prix Nobel en 1976. Imprimerie Royal PA Norstedt & Soner, Stockholm. 110-131.[1][2] ... The 1976 Nobel Prize in Chemistry was awarded to Lipscomb "for his studies on the structure of boranes illuminating problems of ... The diagram at right shows a typical nuclear magnetic resonance (NMR) spectrum of a borane molecule. Lipscomb investigated ... Lipscomb and his graduate students further determined the molecular structure of boranes (compounds of boron and hydrogen) ...
Jemmis mno rules
The Jemmis mno rule provides the relationship between polyhedral boranes, condensed polyhedral boranes, and β-rhombohedral ... the higher boranes and borane anions, and various transition-metal carbonyl cluster compounds". J. Chem. Soc. D (15): 792. doi: ... They were formulated by E. D. Jemmis to explain the structures of condensed polyhedral boranes such as B20H16, which are ... The Jemmis mno rules are an extension of Wade's rules, generalized to include condensed polyhedral boranes as well. The first ...
Dodecaborate
The dodecaborate(12) anion, [B12H12]2−, is a borane with an icosahedral arrangement of 12 boron atoms, with each boron atom ... Miller, H. C.; Muetterties, E. L.; Boone, J. L.; Garrett, P.; Hawthorne, M. F. (2007). "Borane Anions". Inorganic Syntheses. pp ... Boranes, Anions, Substances discovered in the 1960s). ...
Spherical aromaticity
Fullerene chemistry Carborane Boranes Hirsch, Andreas; Chen, Zhongfang; Jiao, Haijun (2000), "Spherical Aromaticity in Ih ... Spherical Aromaticity: Recent Work on Fullerenes, Polyhedral Boranes, and Related Structures (Aromatic compounds, Physical ... polyhedral boranes. In 2000, Andreas Hirsch and coworkers in Erlangen, Germany, formulated a rule to determine when a fullerene ...
Earl Muetterties
Muetterties's work on boron hydride clusters led to the work on several polyhedral borane anions such as B12H122−. He was an ... In addition to the polyhedral boranes, the program explored pi-allyl, fluoroalkyl, and boron hydride complexes of the ... Journal of the American Chemical Society (1957), 79 3686-7. Hawthorne, M. Frederick (March 23, 2009). "Polyhedral Boranes: ... who is known for his experimental work with boranes, homogeneous catalysis, heterogeneous catalysis, fluxional processes in ...
Phosphinimide ligands
Holthausen, Michael H.; Mallov, Ian; Stephan, Douglas W. (2014). "Phosphinimine-substituted boranes and borenium ions". Dalton ...
Swern oxidation
Atkins, William J. Jr.; Burkhardt, Elizabeth R.; Matos, Karl (2006). "Safe Handling of Boranes at Scale". Org. Process Res. Dev ...
Pinacolborane
... is the borane with the formula (CH3)4C2O2BH. Often pinacolborane is abbreviated HBpin. It features a boron ... Brown, H.C.; Zaidlewicz, M. (2001). Organic Syntheses Via Boranes, Vol. 2. Milwaukee, WI: Aldrich Chemical Co. ISBN 978-0- ...
Ray Borane Middle School, Douglas, Arizona (AZ): Student Statistics -SchoolFamily.com
Borane-Catalyzed Ring-Opening and Ring-Closing Cascades of Furans - SYNFORM - Thieme Chemistry
Sehoon Park and Sukbok Chang report a borane-catalyzed synthesis of silicon-functionalized synthetic intermediates. ... Sehoon Park and Sukbok Chang report a borane-catalyzed synthesis of silicon-functionalized synthetic intermediates. ... Borane-Catalyzed Ring-Opening and Ring-Closing Cascades of Furans * Enantioselective Photochemistry through Catalyzed Triplet ... Borane-Catalyzed Ring-Opening and Ring-Closing Cascades of Furans Leading to Silicon-Functionalized Synthetic Intermediates. ...
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Fluorinated boranes in dehydrocoupling and hydroboration - UEA Digital Repository
This thesis describes the chemistry of the Lewis adducts of mono- and bis-(pentafluorophenyl)borane (LB·BHn(C6F5)3−n; n = 1, 2 ... Chapter 2 details the use of Me2S·BHn(C6F5)3−n in the preparation of the pentafluorophenyl substituted amine borane adducts, LB ... The related pentafluorophenyl substituted amine boranes H3N·BHn(C6F5)3−n may be used as ligand precursors for the synthesis of ... This structural feature is proposed to play a significant role in catalytic dehydrocoupling of amine boranes by early ...
Borane-trimethylamine complex - sterilized - Kemai Chemical (Europe) GmbH
Borane-catalyzed stereoselective C-H Insertion, cyclopropanation, and ring-opening reactions
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Behavior and kinetic of hydrolysis of amine boranes in acid media employed in chemical vapor generation. | Anal Chim Acta;998:...
... most probably amine borane cations, formed during amine borane hydrolysis in the same reaction conditions. ... In order to explain this unexpected higher efficiency of amine boranes with respect of THB, the kinetic of hydrolysis of AB, ... This suggests that, at elevated acidities (5 mol L-1 HCl or HClO4), the hydrolysis of amine boranes takes place in two steps, ... This evidence indicates a different mechanism of hydrolysis to the one accepted in the literature for amine boranes. The ...
Highly active Fe<sub>36</sub>Co<sub>44</sub> bimetallic nanoclusters catalysts for hydrolysis of ammonia borane:...
Highly active Fe36Co44 bimetallic nanoclusters catalysts for hydrolysis of ammonia borane: The first-principles study. * ... Highly active Fe36Co44 bimetallic nanoclusters catalysts for hydrolysis of ammonia borane: The first-principles study. * ... Abstract: In this paper, Fe36Co44 nanocluster structure is used to catalyze the hydrolysis reaction of ammonia borane to ... Highly active Fe36Co44 bimetallic nanoclusters catalysts for hydrolysis of ammonia borane: The first-principles study[J]. ...
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Borane-Catalyzed Transfer Hydrogenations of Pyridines with Ammonia Borane. Org. Lett. 2016, 18, 5189-5191. [Google Scholar] [ ... Liu, Z.; He, J.-H.; Zhang, M.; Shi, Z.-J.; Tang, H.; Zhou, X.-Y.; Tian, J.-J.; Wang, X.-C. Borane-Catalyzed C3-Alkylation of ... Yang, Z.-Y.; Luo, H.; Zhang, M.; Wang, X.-C. Borane-Catalyzed Reduction of Pyridines via a Hydroboration/Hydrogenation Cascade ... with boranes, enabling complete reduction with molecular hydrogen [20,21,22,23,24,25]. Partial reduction can also be achieved ...
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Tuning the formal potential of ferrocyanide over a 2.1 V range - Chemical Science (RSC Publishing) DOI:10.1039/C8SC04972F
The borane adducts of 1 were synthesized by combining six equivalents of borane with one equivalent of 1 dissolved in ... We report the synthesis and characterization of homoleptic borane adducts of hexacyanoferrate(II). Borane coordination ... Coordination of borane generated (TEA)4[Fe(CN-BPh3)6] (2) and (PPN)4[Fe(CN-B(C6F5)3)6] (3). Each complex was purified and ... a linear potential shift per borane added to hexacyanoferrate(II) was observed for 3 (Fig. S10†). Borane adducts of Fe(phen)2( ...
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Synthèse stéréosélective de centres tertiaires et quaternaires par voie radicalaire et leur application à la synthèse d...
It was demonstrated that the use of mild Lewis acids can expand the scope of NHC-boranes in hydrogen transfer radical ... No precedent exists for the creation of stereogenic centers using a radical based approach with NHC-boranes. Due to our ... La méthodologie développée au cours de cette seconde partie de thèse est la première application des NHC-boranes pour effectuer ... Curran et Malacria ont grandement participé à lémergence des carbènes N-hétérocycliques (NHC) boranes comme agents de ...
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N-Alkyl-1, 2, 3, 6-tetrahydropyridine derivatives (III-I, IV-I, VI-I, VII-I and VIII-I) and the corresponding borane-amine ... The NiCl2-NaBH4 reduction of the borane-amine complexes gave the perhydrogenated products alone, but not reductive cleavage ... In conclusion, it was recognized that the precursors of reductive cleavage products were not borane-amine complexes, but 1, 2, ... In addition, we pursued whether borane-1, 2, 3, 6-tetrahydropyridine derivative complexes arose from N-alkylpyridinium ...
Jay P. Gore - Our People - Mechanical Engineering - Purdue UniversityAmine boranes8
- The related pentafluorophenyl substituted amine boranes H3N·BHn(C6F5)3−n may be used as ligand precursors for the synthesis of group 4 metallocene amidoborane complexes. (uea.ac.uk)
- This structural feature is proposed to play a significant role in catalytic dehydrocoupling of amine boranes by early transition metal catalysts. (uea.ac.uk)
- Behavior and kinetic of hydrolysis of amine boranes in acid media employed in chemical vapor generation. (bvsalud.org)
- The behavior of NaBH4 (THB) and the amine boranes , NH3BH3 (AB), tertbutylNH2BH3 (TBAB), Me2NHBH3 (DMAB) was investigated in continuous flow chemical vapor generation of H2Se from aqueous SeIV coupled with atomic absorption spectrometry . (bvsalud.org)
- In order to explain this unexpected higher efficiency of amine boranes with respect of THB, the kinetic of hydrolysis of AB, TBAB and DMAB was investigated in acid media typically employed in chemical vapor generation for trace element determination . (bvsalud.org)
- Under strongly acidic conditions, the rates of hydrogen evolution produced by amine boranes hydrolysis appear to be much slower than those predicted by a pseudo-first order reaction and using the rate constants reported in the literature . (bvsalud.org)
- This suggests that, at elevated acidities (5 mol L-1 HCl or HClO4), the hydrolysis of amine boranes takes place in two steps, generating a first amount of H2 (0.67-1.15 mol) much faster than the remaining about 2 mol. (bvsalud.org)
- This evidence indicates a different mechanism of hydrolysis to the one accepted in the literature for amine boranes . (bvsalud.org)
Adducts5
- Chapter 2 details the use of Me2S·BHn(C6F5)3−n in the preparation of the pentafluorophenyl substituted amine borane adducts, LB·BHn(C6F5)3−n (LB = NR3, NHR2, NH2R, py). (uea.ac.uk)
- Duward Shriver pioneered the study of borane adducts of cyanometalates. (rsc.org)
- 1a-d Although he established from analysis of vibrational spectroscopic data that borane coordination (CN-BR 3 ) enhanced M(d 6 )-CN π backbonding, surprisingly, to the best of our knowledge, no structures of d 6 low-spin borane adducts have been hitherto reported. (rsc.org)
- 3,4 Also surprising is that very little is known about the electrochemistry of coordinatively-saturated borane adducts of hexacyanometalates, with the majority of previous work focused on the solvent dependence of cyanometalate redox potentials. (rsc.org)
- The borane adducts of 1 were synthesized by combining six equivalents of borane with one equivalent of 1 dissolved in dichloromethane (DCM) in a nitrogen-filled glove box. (rsc.org)
Catalysts1
- Lewis acidic boranes have been shown to be effective metal-free catalysts for highly selective reactions of donor-acceptor diazo compounds to a range of substrates. (edu.au)
Hydrolysis2
- The relatively high efficiencies of H2Se observed with amine borane reduction of inorganic SeIV at elevated acidities can be addressed to the action of borane intermediates, most probably amine borane cations , formed during amine borane hydrolysis in the same reaction conditions. (bvsalud.org)
- In this paper, Fe 36 Co 44 nanocluster structure is used to catalyze the hydrolysis reaction of ammonia borane to produce H 2 . (ccspublishing.org.cn)
Tris1
- In this month's Editor's Collection, Associate Editor Santanu Mukherjee highlighted 'Tris(pentafluorophenyl)borane Catalyzed C−C and C−heteroatom Bond Formation' by Chatterjee et al. (rsc.org)
Intermediates1
- Sehoon Park and Sukbok Chang report a borane-catalyzed synthesis of silicon-functionalized synthetic intermediates. (thieme.de)
Lewis1
- Control over redox properties is established with respect to borane Lewis acidity, reflected in peak anodic potential shifts per borane of +250 mV for BPh 3 and +350 mV for B(C 6 F 5 ) 3 . (rsc.org)
Hydroboration1
- Many reactions of alkenes are initiated by hydroboration , then conversion of the resulting alkyl borane. (organic-chemistry.org)
Boron5
- Borane clusters are classified as follows, where n is the number of boron atoms in a single cluster: The International Union of Pure and Applied Chemistry rules for systematic naming is based on a prefix denoting a class of compound, followed by the number of boron atoms and finally the number of hydrogen atoms in parentheses. (wikipedia.org)
- Borane BH3 Diborane(6) B2H6 arachno-Tetraborane(10) B4H10 Pentaborane(9) B5H9 Decaborane(14) B10H14 Octadecaborane(22) B18H22 iso-B18H22 Hexaborate(6) B6H62− Heptaborate(7) B7H72− Octaborate(8) B8H82− Nonaborate(9) B9H92− Decaborate(10) B10H102− Undecaborate(11) B11H112− Dodecaborate(12) B12H122− The naming of anions is illustrated by octahydridopentaborate, B5H8− The hydrogen count is specified first followed by the boron count. (wikipedia.org)
- For example, reaction of a borane cluster with B2H6 (as a source of BH3) can lead to the formation of a conjuncto-borane species in which borane cluster sub-units are joined by the sharing of boron atoms. (wikipedia.org)
- Boric acid is used in cosmetics, borides, boron oxides, borates, boranes, been derived for acute-duration oral susceptible to boron poisoning than pharmaceuticals, and toiletries. (cdc.gov)
- Chemical vapour deposition uses the reaction of gaseous carbon black and borane at high temperature to create boron carburide. (inwin-style.com)
Synthesis1
- Borane-based reagents are now widely used in organic synthesis. (wikipedia.org)
Hydrogen2
- Interest in boranes increased during World War II due to the potential of uranium borohydride for enrichment of the uranium isotopes and as a source of hydrogen for inflating weather balloons. (wikipedia.org)
- Ammonia-Borane (NH 3 BH 3 , AB), which has the most hydrogen-containing borohydride (19.6 wt%), high thermal stability, long-term stability in aqueous solutions and low toxicity, is becoming the leading contender for chemical hydrogen-storage materials. (ccspublishing.org.cn)
Species1
- Full borane coordination for all species was confirmed by analysis of X-ray crystallographic data (see ESI † ), with representative structures depicted in Fig. 1 . (rsc.org)
Behavior1
- Reminiscent of the behavior of diborane, some lower boranes react with air very exothermically, even explosively. (wikipedia.org)
Cluster2
- By contrast, many closo-borane cluster, such as B12H122−, do not react with air. (wikipedia.org)
- By comparing the adsorption process of Ammonia Borane (AB) in active sites of the cluster, which have different Effective Coordination Number (ECN), the qualitative relationship between ECN and the catalytic activation of AB is clarified, and the optimal catalytic active site is obtained. (ccspublishing.org.cn)
Synthetic1
- The development of the chemistry of boranes led to innovations in synthetic methods as well as structure and bonding. (wikipedia.org)
Structures2
- Although they have few practical applications, the boranes exhibit structures and bonding that differs strongly from the patterns seen in hydrocarbons. (wikipedia.org)
- The bonding of the clusters ushered in Polyhedral skeletal electron pair theory and Wade's rules, which can be used to predict the structures of boranes. (wikipedia.org)
Study1
- The objective of this study was (1) to evaluate the effectiveness of Megabond when used with Superbond C&B, a 4-methacryloloxyethyl trimellitate anhydride (4-META)/methyl methacrylate (MMA)-tri-n-butyl borane (TBB) resin, to bond orthodontic metal brackets to human enamel and (2) to examine the influence of saliva contamination on shear bond strength. (who.int)
Application1
- La méthodologie développée au cours de cette seconde partie de thèse est la première application des NHC-boranes pour effectuer un transfert d'hydrogène radicalaire diastéréosélectif. (umontreal.ca)
Description1
- A description of the bonding in the larger boranes was formulated by William Lipscomb. (wikipedia.org)
Made1
- B6H10 + (BH3) → B7H11 + H2 B7H11 + B6H10 → B13H19 + H2 Other conjuncto-boranes, where the sub-units are joined by a B-B bond, can be made by ultra violet irradiation of nido-boranes. (wikipedia.org)
Dimethylamine3
- Metabolism and disposition of [(14)C]dimethylamine borane in male Harlan Sprague Dawley rats following gavage administration, intravenous administration and dermal application. (nih.gov)
- An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Dimethylamine borane (74-94-2). (nih.gov)
- Genetic Toxicity Evaluation of Dimethylamine Borane in Salmonella/E.coli Mutagenicity Test or Ames Test. (nih.gov)
Carboranes1
- Hybrids of boranes and hydrocarbons, the carboranes are also well developed. (wikipedia.org)
Reactions1
- This was achieved by reactions of propargyl amines with Lewis acidic boranes under mild conditions. (rsc.org)
Complexes3
- 4. Amine- and dimeric amino-borane complexes of the {Rh(P(i)Pr3)2}+ fragment and their relevance to the transition-metal-mediated dehydrocoupling of amine-boranes. (nih.gov)
- 11. Monomeric and oligomeric amine-borane sigma-complexes of rhodium. (nih.gov)
- 12. Ambiphilic diphosphine-borane ligands: metal-->borane interactions within isoelectronic complexes of rhodium, platinum and palladium. (nih.gov)
Compounds1
- Boranes are nonclassically-bonded compounds, that is, there are not enough electrons to form 2-centre, 2-electron bonds between all pairs of adjacent atoms in the molecule. (wikipedia.org)
Mechanism1
- The mechanism involved borane-mediated alkyne activation and intramolecular hydride transfer, thus realizing a unique hydroboration in the absence of a B-H bond. (rsc.org)
Catalyst1
- Some B-B coupled conjuncto-boranes can be produced using PtBr2 as catalyst. (wikipedia.org)
Formula1
- A borane is a compound with the formula BxHy or a related anion. (wikipedia.org)
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