The grafting of bone from a donor site to a recipient site.
Centers for acquiring, characterizing, and storing bones or bone tissue for future use.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
The transference of a part of or an entire liver from one human or animal to another.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
The transference of a kidney from one human or animal to another.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Transplantation of an individual's own tissue from one site to another site.
The transference of a heart from one human or animal to another.
The transference of either one or both of the lungs from one human or animal to another.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
Transference of an organ between individuals of the same species or between individuals of different species.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Bone loss due to osteoclastic activity.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
The transference of a pancreas from one human or animal to another.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.
Transference of cells within an individual, between individuals of the same species, or between individuals of different species.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
Tumors or cancer located in bone tissue or specific BONES.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
Diseases of BONES.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.
Elements of limited time intervals, contributing to particular results or situations.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Transference of fetal tissue between individuals of the same species or between individuals of different species.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Transplantation between animals of different species.
The return of a sign, symptom, or disease after a remission.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
Prospective patient listings for appointments or treatments.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.

Support of the anterior column with allografts in tuberculosis of the spine. (1/1358)

Fresh-frozen allografts from the humerus were used to help to stabilise the spine after anterior decompression for tuberculosis in 47 children with a mean age of 4.2 years (2 to 9). The average angle of the gibbus, before operation, was 53 degrees; at follow-up, two years later, it was 15 degrees. Rejection of the graft or deep sepsis was not seen. Cross trabeculation between the allograft and the vertebral body was observed at six months, with remodelling occurring at approximately 30 months.  (+info)

Mechanical considerations in impaction bone grafting. (2/1358)

In impaction grafting of contained bone defects after revision joint arthroplasty the graft behaves as a friable aggregate and its resistance to complex forces depends on grading, normal load and compaction. Bone mills in current use produce a distribution of particle sizes more uniform than is desirable for maximising resistance to shear stresses. We have performed experiments in vitro using morsellised allograft bone from the femoral head which have shown that its mechanical properties improve with increasing normal load and with increasing shear strains (strain hardening). The mechanical strength also increases with increasing compaction energy, and with the addition of bioglass particles to make good the deficiency in small and very small fragments. Donor femoral heads may be milled while frozen without affecting the profile of the particle size. Osteoporotic femoral heads provide a similar grading of sizes, although fewer particles are obtained from each specimen. Our findings have implications for current practice and for the future development of materials and techniques.  (+info)

Evaluation of the allograft-prosthesis composite technique for proximal femoral reconstruction after resection of a primary bone tumour. (3/1358)

OBJECTIVE: To evaluate clinical and functional outcomes resulting from the allograft-composite technique used for proximal femoral osteoarticular reconstruction in patients who had limb salvage surgery for primary bone tumours. DESIGN: A retrospective review of a prospectively gathered database to provide a descriptive study. SETTING: A tertiary care musculoskeletal oncology unit in a university hospital. PATIENTS AND INTERVENTIONS: Patients treated between 1987 and 1993 were eligible for inclusion in this study if they met the following criteria: they were treated surgically for a primary malignant bone tumour; and a proximal femoral allograft-implant composite technique was used for the reconstruction. MAIN OUTCOME MEASURES: Major postoperative complications with emphasis on mechanical complications in the reconstructive composite implant. Functional outcome in a subset of patients using the 1987 and 1994 versions of the Musculoskeletal Tumor Society instrument, the Short-Form-36 and the Toronto Extremity Salvage Score. RESULTS: There were 5 mechanical and 2 infectious complications requiring surgical intervention. Functional scores were generally low. CONCLUSIONS: Our results suggest that the perceived benefits of the composite technique may accrue only to a few patients, partly owing to the risk of mechanical complications. Although these can be reduced by avoiding the use of cement in the host femur, the generally poor functional outcomes suggest that this technique needs to be studied further in this group of patients and compared with other reconstructive techniques, particularly the prosthetic implant.  (+info)

Bone-peg grafting for osteochondritis dissecans of the elbow. (4/1358)

In the treatment of osteochondritis dissecans involving the elbow, we have used a bone-peg graft taken from the proximal part of the ulna and inserted into the defect. Thirty-two patients were followed from 2 to 10.5 years. The graft was utilised in 20 elbows, and 6 of these also had concomitant removal of a loose body. Another 6 elbows had removal of a loose body only. Ten elbows were treated conservatively in 5 of these the outcome was unsatisfactory, including 4 in which a bone-peg graft was later necessary. The bone-peg graft gave the best short-term results. Bony union of the dissecans site and reconstitution of subchondral bone required an average of 6.5 months. In 15 patients followed for a minimum of 5 years, the bone-peg graft was effective in limiting the development of osteoarthritis. Bone-peg grafting is a reliable method for treating osteochondritis dissecans of the elbow.  (+info)

Salvage of the head of the radius after fracture-dislocation of the elbow. A case report. (5/1358)

We describe a patient with a Mason type-III fracture of the head of the radius associated with traumatic dislocation of the elbow. The radial head was intact throughout its circumference despite being completely detached from the shaft and devoid of any soft-tissue attachments. Severe comminution of the radial neck prevented reconstruction by internal fixation and precluded prosthetic replacement of the head. The head was fixed to the shaft with a tricortical iliac-crest bone graft which replaced the neck. Two years later, the patient had a stable elbow with flexion from 10 degrees to 130 degrees. Radiologically, the head of the radius appeared to be viable and the bone graft had incorporated.  (+info)

The pathology of bone allograft. (6/1358)

We analysed the histological findings in 1146 osteoarthritic femoral heads which would have been considered suitable for bone-bank donation to determine whether pathological lesions, other than osteoarthritis, were present. We found that 91 femoral heads (8%) showed evidence of disease. The most common conditions noted were chondrocalcinosis (63 cases), avascular necrosis (13), osteomas (6) and malignant tumours (one case of low-grade chondrosarcoma and two of well-differentiated lymphocytic lymphoma). There were two with metabolic bone disease (Paget's disease and hyperparathyroid bone disease) and four with inflammatory (rheumatoid-like) arthritis. Our findings indicate that occult pathological conditions are common and it is recommended that histological examination of this regularly used source of bone allograft should be included as part of the screening protocol for bone-bank collection.  (+info)

Histopathology of retrieved allografts of the femoral head. (7/1358)

From November 1994 to March 1997, we harvested 137 grafts of the femoral head from 125 patients for donation during total hip arthroplasty according to the guidelines of the American Associations of Tissue Banks (AATB) and the European Association of Musculo-Skeletal transplantation (EAMST). In addition to the standards recommended by these authorities, we performed histopathological examination of a core biopsy of the retrieved bone allograft and of the synovium. Of the 137 allografts, 48 (35.0%) fulfilled all criteria and were free for donation; 31 (22.6%) were not regarded as suitable for transplantation because the serological retests at six months were not yet complete and 58 (42.3%) were discarded because of incomplete data. Of those discarded, five showed abnormal histopathological findings; three were highly suspicious of low-grade B-cell lymphoma, one of monoclonal plasmacytosis and the other of non-specific inflammation of bone marrow. However, according to the standards of the AATB or EAMST they all met the criteria and were eligible for transplantation. Our findings indicate that the incidence of abnormal histopathology in these retrieved allografts was 3.6%. Since it is essential to confirm the quality of donor bones in bone banking, we advise that histopathological screening of donor bone should be performed to exclude abnormal allografts.  (+info)

Multi-bracket appliance in management of mandibular reconstruction with vascularized bone graft. (8/1358)

BACKGROUND: The most commonly used tool for maxillo-mandibular fixation to the patient who underwent reconstruction using a vascularized bone graft after mandibular resection is a dental arch-bar. However, the occlusal relationship achieved by this method is not ideal. Different from the dental arch-bar, the multi-bracket appliance which is frequently used in orthodontic treatment can control the position of each individual tooth three dimensionally. Thus, this appliance was applied for maxillo-mandibular fixation to patients who underwent mandibular reconstruction using a vascularized bone graft. METHODS: A multi-bracket appliance was applied to three patients. Prior to the surgery, standard edgewise brackets were bonded to the teeth in the maxilla and in the remaining mandible. After mandibular resection, wires for maxillo-mandibular fixation were applied. The harvested bone was then carefully fixed with miniplates to maintain the occlusion. The multi-bracket appliance was worn for 3 months when the wound contraction became mild. RESULTS: All three cases demonstrated stable and good occlusion. They also demonstrated satisfactory post-surgical facial appearance. CONCLUSIONS: Compared to conventional dental arch-bars, a multi-bracket appliance offers improved management of mandibular reconstruction. Firstly, its properties are helpful in maintaining occlusion of the remaining dentition accurately in bone grafting procedure as well as protecting against postsurgical wound contraction. Secondly, the multi-bracket appliance keeps the oral cavity clean without periodontal injury. As a result, stable occlusion of the residual teeth and good facial appearance were obtained.  (+info)

There are several factors that can contribute to bone resorption, including:

1. Hormonal changes: Hormones such as parathyroid hormone (PTH) and calcitonin can regulate bone resorption. Imbalances in these hormones can lead to excessive bone resorption.
2. Aging: As we age, our bones undergo remodeling more frequently, leading to increased bone resorption.
3. Nutrient deficiencies: Deficiencies in calcium, vitamin D, and other nutrients can impair bone health and lead to excessive bone resorption.
4. Inflammation: Chronic inflammation can increase bone resorption, leading to bone loss and weakening.
5. Genetics: Some genetic disorders can affect bone metabolism and lead to abnormal bone resorption.
6. Medications: Certain medications, such as glucocorticoids and anticonvulsants, can increase bone resorption.
7. Diseases: Conditions such as osteoporosis, Paget's disease of bone, and bone cancer can lead to abnormal bone resorption.

Bone resorption can be diagnosed through a range of tests, including:

1. Bone mineral density (BMD) testing: This test measures the density of bone in specific areas of the body. Low BMD can indicate bone loss and excessive bone resorption.
2. X-rays and imaging studies: These tests can help identify abnormal bone growth or other signs of bone resorption.
3. Blood tests: Blood tests can measure levels of certain hormones and nutrients that are involved in bone metabolism.
4. Bone biopsy: A bone biopsy can provide a direct view of the bone tissue and help diagnose conditions such as Paget's disease or bone cancer.

Treatment for bone resorption depends on the underlying cause and may include:

1. Medications: Bisphosphonates, hormone therapy, and other medications can help slow or stop bone resorption.
2. Diet and exercise: A healthy diet rich in calcium and vitamin D, along with regular exercise, can help maintain strong bones.
3. Physical therapy: In some cases, physical therapy may be recommended to improve bone strength and mobility.
4. Surgery: In severe cases of bone resorption, surgery may be necessary to repair or replace damaged bone tissue.

Some common types of bone neoplasms include:

* Osteochondromas: These are benign tumors that grow on the surface of a bone.
* Giant cell tumors: These are benign tumors that can occur in any bone of the body.
* Chondromyxoid fibromas: These are rare, benign tumors that develop in the cartilage of a bone.
* Ewing's sarcoma: This is a malignant tumor that usually occurs in the long bones of the arms and legs.
* Multiple myeloma: This is a type of cancer that affects the plasma cells in the bone marrow.

Symptoms of bone neoplasms can include pain, swelling, or deformity of the affected bone, as well as weakness or fatigue. Treatment options depend on the type and location of the tumor, as well as the severity of the symptoms. Treatment may involve surgery, radiation therapy, chemotherapy, or a combination of these.

Some common types of bone diseases include:

1. Osteoporosis: A condition characterized by brittle, porous bones that are prone to fracture.
2. Osteoarthritis: A degenerative joint disease that causes pain and stiffness in the joints.
3. Rheumatoid arthritis: An autoimmune disorder that causes inflammation and pain in the joints.
4. Bone cancer: A malignant tumor that develops in the bones.
5. Paget's disease of bone: A condition characterized by abnormal bone growth and deformity.
6. Osteogenesis imperfecta: A genetic disorder that affects the formation of bone and can cause brittle bones and other skeletal deformities.
7. Fibrous dysplasia: A rare condition characterized by abnormal growth and development of bone tissue.
8. Multiple myeloma: A type of cancer that affects the plasma cells in the bone marrow.
9. Bone cysts: Fluid-filled cavities that can form in the bones and cause pain, weakness, and deformity.
10. Bone spurs: Abnormal growths of bone that can form along the edges of joints and cause pain and stiffness.

Bone diseases can be diagnosed through a variety of tests, including X-rays, CT scans, MRI scans, and bone biopsies. Treatment options vary depending on the specific disease and can include medication, surgery, or a combination of both.

The diagnosis of GVHD is based on a combination of clinical findings, laboratory tests, and biopsies. Treatment options include immunosuppressive drugs, corticosteroids, and in severe cases, stem cell transplantation reversal or donor lymphocyte infusion.

Prevention of GVHD includes selecting the right donor, using conditioning regimens that minimize damage to the recipient's bone marrow, and providing appropriate immunosuppression after transplantation. Early detection and management of GVHD are critical to prevent long-term complications and improve survival rates.

There are several causes of liver failure, including:

1. Alcohol-related liver disease: Prolonged and excessive alcohol consumption can damage liver cells, leading to inflammation, scarring, and eventually liver failure.
2. Viral hepatitis: Hepatitis A, B, and C are viral infections that can cause inflammation and damage to the liver, leading to liver failure.
3. Non-alcoholic fatty liver disease (NAFLD): A condition where there is an accumulation of fat in the liver, leading to inflammation and scarring.
4. Drug-induced liver injury: Certain medications can cause liver damage and failure, especially when taken in high doses or for extended periods.
5. Genetic disorders: Certain inherited conditions, such as hemochromatosis and Wilson's disease, can cause liver damage and failure.
6. Acute liver failure: This is a sudden and severe loss of liver function, often caused by medication overdose or other toxins.
7. Chronic liver failure: A gradual decline in liver function over time, often caused by cirrhosis or NAFLD.

Symptoms of liver failure can include:

1. Jaundice (yellowing of the skin and eyes)
2. Fatigue
3. Loss of appetite
4. Nausea and vomiting
5. Abdominal pain
6. Confusion and altered mental state
7. Easy bruising and bleeding

Diagnosis of liver failure is typically made through a combination of physical examination, medical history, and laboratory tests, such as blood tests to check for liver enzymes and bilirubin levels. Imaging tests, such as ultrasound and CT scans, may also be used to evaluate the liver.

Treatment of liver failure depends on the underlying cause and severity of the condition. In some cases, a liver transplant may be necessary. Other treatments may include medications to manage symptoms, such as nausea and pain, and supportive care to maintain nutrition and hydration. In severe cases, hospitalization may be required to monitor and treat complications.

Prevention of liver failure is important, and this can be achieved by:

1. Avoiding alcohol or drinking in moderation
2. Maintaining a healthy weight and diet
3. Managing underlying medical conditions, such as diabetes and high blood pressure
4. Avoiding exposure to toxins, such as certain medications and environmental chemicals
5. Getting vaccinated against hepatitis A and B
6. Practicing safe sex to prevent the spread of hepatitis B and C.

1. Infection: Bacterial or viral infections can develop after surgery, potentially leading to sepsis or organ failure.
2. Adhesions: Scar tissue can form during the healing process, which can cause bowel obstruction, chronic pain, or other complications.
3. Wound complications: Incisional hernias, wound dehiscence (separation of the wound edges), and wound infections can occur.
4. Respiratory problems: Pneumonia, respiratory failure, and atelectasis (collapsed lung) can develop after surgery, particularly in older adults or those with pre-existing respiratory conditions.
5. Cardiovascular complications: Myocardial infarction (heart attack), cardiac arrhythmias, and cardiac failure can occur after surgery, especially in high-risk patients.
6. Renal (kidney) problems: Acute kidney injury or chronic kidney disease can develop postoperatively, particularly in patients with pre-existing renal impairment.
7. Neurological complications: Stroke, seizures, and neuropraxia (nerve damage) can occur after surgery, especially in patients with pre-existing neurological conditions.
8. Pulmonary embolism: Blood clots can form in the legs or lungs after surgery, potentially causing pulmonary embolism.
9. Anesthesia-related complications: Respiratory and cardiac complications can occur during anesthesia, including respiratory and cardiac arrest.
10. delayed healing: Wound healing may be delayed or impaired after surgery, particularly in patients with pre-existing medical conditions.

It is important for patients to be aware of these potential complications and to discuss any concerns with their surgeon and healthcare team before undergoing surgery.

Recurrence can also refer to the re-emergence of symptoms in a previously treated condition, such as a chronic pain condition that returns after a period of remission.

In medical research, recurrence is often studied to understand the underlying causes of disease progression and to develop new treatments and interventions to prevent or delay its return.

* Osteogenesis imperfecta (OI): A genetic disorder that affects the formation of bone tissue, leading to fragile bones and an increased risk of fractures.
* Rickets: A vitamin D-deficient disease that causes softening of the bones in children.
* Osteomalacia: A condition similar to rickets, but affecting adults and caused by a deficiency of vitamin D or calcium.
* Hyperparathyroidism: A condition in which the parathyroid glands produce too much parathyroid hormone (PTH), leading to an imbalance in bone metabolism and an increase in bone resorption.
* Hypoparathyroidism: A condition in which the parathyroid glands produce too little PTH, leading to low levels of calcium and vitamin D and an increased risk of osteoporosis.

Bone diseases, metabolic are typically diagnosed through a combination of physical examination, imaging studies such as X-rays or CT scans, and laboratory tests to evaluate bone metabolism. Treatment depends on the specific underlying cause of the disease and may include medications, dietary changes, or surgery.

Bone Marrow Transplantation is a peer-reviewed medical journal covering transplantation of bone marrow in humans. It is ... Bone Marrow Transplantation has a 2020 impact factor of 5.483. Bone Marrow Transplantation is abstracted and indexed in BIOBASE ... "Bone Marrow Transplantation". 2020 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2021. Official ... The scope of the journal includes stem cell biology, transplantation immunology, translational research, and clinical results ...
Bone Marrow Transplantation. 25 (5): 501-5. doi:10.1038/sj.bmt.1702173. PMID 10713626. "Bone Marrow Transplantation and ... where the transplanted cells override the previous bone marrow. This allows the bone marrow to recover, proliferate and ... PBSCT is now a much more common procedure than its bone marrow harvest equivalent due to the ease and less invasive nature of ... Peripheral stem cell transplantation entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public ...
Bone-marrow transplantation usually requires that the recipient's own bone marrow be destroyed (myeloablation). Prior to the ... Stem-cell transplantation was pioneered using bone marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research ... It is aptly named graft-versus-host disease because bone-marrow transplantation is the only transplant procedure in which the ... Wikimedia Commons has media related to Hematopoietic stem cell transplantation. Bone marrow transplant - What happens on NHS ...
October 1997). "Gianotti-Crosti syndrome associated with cytomegalovirus antigenemia after bone marrow transplantation". Bone ... Marrow Transplantation. 20 (8): 691-3. doi:10.1038/sj.bmt.1700945. PMID 9383234. Chandrasekaran M, Mukherjee S (September 2007 ...
HLA non-identical bone marrow transplants in a series of 10 patients". Bone Marrow Transplantation. 29 (9): 759-762. doi: ... Transplantation is a simple process. Bone marrow product is infused through a central vein over a period of several hours. The ... Transplantation of stem cells are taken from the bone marrow, peripheral blood or umbilical cord of healthy, matched donors. ... This cure is commonly used in patients who are awaiting bone marrow transplantation. Response to this cure can vary. Those with ...
Bone Marrow Transplantation. 37 (2): 207-212. doi:10.1038/sj.bmt.1705218. ISSN 0268-3369. PMID 16284610. (Wikipedia articles ... was found to correlate with the absence of GvHD after bone marrow transplantation, while decreased numbers of Tr1 markedly ... Transplantation research has shown, that donor Tr1 in response to recipient alloantigens, ... "Regulatory T cells and dendritic cells in transplantation tolerance: molecular markers and mechanisms". Immunological Reviews. ...
"Unexpected complications after bone marrow transplantation in transfusion-dependent children". Bone Marrow Transplantation. 12 ... Bone marrow transplantation (BMT) can cure hematological aspects of DBA. This option may be considered when patients become ... This is in contrast to Shwachman-Bodian-Diamond syndrome, in which the bone marrow defect results primarily in neutropenia, and ... a diagnosis of DBA is made through a blood count and a bone marrow biopsy. A diagnosis of DBA is made on the basis of anemia, ...
"Stem cell transplantation for primary immunodeficiencies". Bone Marrow Transplantation. 41 (S2): S83-S86. doi:10.1038/bmt. ... Bone marrow transplant may be possible for Severe Combined Immune Deficiency and other severe immunodeficiences. Virus-specific ... T-lymphocytes (VST) therapy is used for patients who have received hematopoietic stem cell transplantation that has proven to ...
This phenomenon is used in bone marrow transplantation, when a small number of Hematopoietic stem cells reconstitute the ... In adults, haematopoiesis occurs in the red bone marrow, in the core of most bones. The red bone marrow is derived from the ... may travel in the blood from the bone marrow in one bone to another bone. If they settle in the thymus, they may develop into T ... This process indicates that, subsequent to bone marrow transplantation, symmetrical cell divisions into two daughter ...
Bone Marrow Transplantation. 50 (9): 1150-6. doi:10.1038/bmt.2015.80. PMID 25915812. Tay J, Levesque JP, Winkler IG (December ... and transplantation". Biology of Blood and Marrow Transplantation. 12 (6): 672-82. doi:10.1016/j.bbmt.2006.02.006. PMID ... White blood cells The G-CSF-receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF ... A study in mice has shown that G-CSF may decrease bone mineral density. G-CSF administration has been shown to attenuate the ...
"E Donnall Thomas (1920-2012)". Bone Marrow Transplantation. 48 (1): 1. 2013. doi:10.1038/bmt.2012.254. ISSN 1476-5365. S2CID ...
March 1997). "Factors predicting morbidity following hematopoietic stem cell transplantation". Bone Marrow Transplantation. 19 ... Bone Marrow Transplantation. 37 (5): 499-502. doi:10.1038/sj.bmt.1705262. PMID 16415895. Suzuki A, Nakauchi H, Taniguchi H ( ... Perry SS, Wang H, Pierce LJ, Yang AM, Tsai S, Spangrude GJ (April 2004). "L-selectin defines a bone marrow analog to the thymic ... 1984). "Bone marrow monosomy 7: hematologic and clinical manifestations in childhood and adolescence". Hematological Oncology. ...
... post-transplantation cyclophosphamide". Bone Marrow Transplantation. 50 Suppl 2: S31-6. doi:10.1038/bmt.2015.92. PMC 4634886. ... "Haploidentical bone marrow and stem cell transplantation: experience with post-transplantation cyclophosphamide". Seminars in ... Bone Marrow Transplantation. 24 (12): 1367-8. doi:10.1038/sj.bmt.1702097. PMID 10627651. Vigouroux D, Voltaire L (1995). "[ ... Or-Geva N, Reisner Y (March 2016). "The evolution of T-cell depletion in haploidentical stem-cell transplantation". British ...
January 25, 2007). False Hope: Bone Marrow Transplantation for Breast Cancer. Oxford University Press. pp. 222-223. ISBN ... Bone Marrow Transplantation. 25 (7): 797-799. doi:10.1038/sj.bmt.1702222. PMID 10745268. Goldberg, Stuart; Pecora, Andrew; et ... to become assistant director of stem cell and bone marrow transplantation from 1990 to 1993. He became the program's chief ... cells as it relates to chemotherapy treatment and bone marrow transplantation for the treatment of non-Hodgkin's lymphoma (NHL ...
Bone Marrow Transplantation. 47 (10): 1377-1378. doi:10.1038/bmt.2012.33. PMC 4547590. PMID 22388279. "Skysona: Pending EC ... The accepted treatment for affected boys presenting with the cerebral childhood form of the disease is a bone marrow transplant ... Cartier, Nathalie; Aubourg, Patrick (27 October 2009). "Hematopoietic Stem Cell Transplantation and Hematopoietic Stem Cell ... which is then transplanted into the patients using a similar procedure as for a bone marrow or stem cell transplant. Gene ...
Bone Marrow Transplantation. 52 (7): 941-949. doi:10.1038/bmt.2016.340. PMID 28112752. Ewend MG, Brem S, Gilbert M, Goodkin R, ... It is also used as part of a chemotherapeutic protocol in preparation for hematological stem cell transplantation, a type of ... bone marrow transplant, in order to reduce the white blood cell count in the recipient. Use under this protocol, usually with ...
A retrospective study from the CMWP EBMT" (PDF). Bone Marrow Transplantation. 57 (3): 499-501. doi:10.1038/s41409-021-01560-y. ... March 2022). "Daratumumab after allogeneic hematopoietic cell transplantation for multiple myeloma is safe and synergies with ...
Bone Marrow Transplantation. 55 (9): 1706-1715. doi:10.1038/s41409-020-0956-8. ISSN 1476-5365. PMID 32474570. S2CID 218987876. ... Transplantation Proceedings. 21 (1 Pt 1): 127-30. PMID 2784887. Rosenbaum L (October 2017). "Tragedy, Perseverance, and Chance ... something that could be utilized in organ transplantation or rheumatic diseases like lupus. There are serious side effects that ...
"The US National Marrow Donor Program role in unrelated donor hematopoietic cell transplantation". Bone Marrow Transplantation. ... Bone Marrow: Marrow is found in the hollow cavities of the body's large bones. Donation involves withdrawing 2-3 percent of the ... a German bone marrow registry, also operates a large US bone marrow registry. "Financials". Retrieved 2019- ... "Bone-marrow donors give a 'huge gift of hope'". WCVB. March 28, 2016. Retrieved June 25, 2016. "Saving a Life is Easier Than ...
Bone Marrow Transplantation. 35 (6): 595-599. doi:10.1038/sj.bmt.1704797. PMID 15665849. "Medical Abstract". namazi hospital ... The first living-related kidney transplantation performed at Shiraz University Hospital dates back to 1968. The hospital has an ... leukocytes and antigenemia for diagnosis of active human cytomegalovirus infection in bone marrow transplant patients". ...
... and neuropsychological outcome of hematopoietic cell transplantation for Wolman disease". Bone Marrow Transplantation. 43 (1): ... Some children with LAL-D have had an experimental therapy called hematopoietic stem cell transplantation (HSCT), also known as ... liver transplantation was necessary in most patients. Infants with LAL deficiencies typically show signs of disease in the ... bone marrow transplant, to try to prevent the disease from getting worse. Data are sparse but there is a known high risk of ...
Bone Marrow Transplantation. 47 (1): 46-53. doi:10.1038/bmt.2011.15. PMID 21358688. Zohren F, Czibere A, Bruns I, et al. ( ... Bone Marrow Transplantation. 44 (12): 785-92. doi:10.1038/bmt.2009.83. PMID 19430496. Schmid C, Weisser M, Ledderose G, Stötzer ... March 2012). "Upfront allogeneic blood stem cell transplantation for patients with high-risk myelodysplastic syndrome or ... June 2011). "Successful allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia during respiratory ...
Bone Marrow Transplantation. 20 (9): 789-791. doi:10.1038/sj.bmt.1700969. PMID 9384484. Duggan, J.M.; Wolf, M.D.; Kauffiman, C. ... While the spread of chromoblastomycosis to the muscle and bone is usually rare, in cases where antifungal drugs alone are ...
Bone Marrow Transplantation. 28 (12): 1171-3. doi:10.1038/sj.bmt.1703288. ISSN 0268-3369. PMID 11803363. Livermore DM ( ... infection of the bone and bone marrow); and uncomplicated skin and soft tissue infections caused by S. pyogenes or S. aureus. ... Bone marrow suppression was not identified during Phase III trials, in which treatment did not exceed 21 days. Although some ... Linezolid is readily distributed to all tissues in the body apart from bone matrix and white adipose tissue. Notably, the ...
Bone Marrow Transplantation. 31 (8): 705-712. doi:10.1038/sj.bmt.1703870. PMID 12692611. Haas M et al. 50th ASTRO congress 2008 ... randomized clinical trial in patients undergoing bone marrow transplantation. This trial demonstrated that Caphosol, used in ... were evaluated in 95 patients undergoing bone marrow transplantation. The treatment arm received 4 topical fluoride treatments ... The results showed: More than twice as many bone marrow transplant patients avoided oral mucositis by using Caphosol Duration ...
Bone Marrow Transplantation. 15 (6): 825-828. ISSN 0268-3369. PMID 7581076. Jennette, J. C.; Falk, R. J.; Bacon, P. A.; Basu, N ...
Bone Marrow Transplantation. 32 (4): 391-8. doi:10.1038/sj.bmt.1704152. PMID 12900775. Lee E, Min HK, Oskeritzian CA, Kambe N, ... in bone marrow, to immature neutrophils". Comptes Rendus de l'Académie des Sciences, Série III. 324 (12): 1125-32. doi:10.1016/ ... "Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation". ...
Bone Marrow Transplantation. 31 (5): 361-369. doi:10.1038/sj.bmt.1703816. PMID 12634727. FLT3 signaling (Articles with short ...
Bone Marrow Transplantation. 38 (5): 365-370. doi:10.1038/sj.bmt.1705450. ISSN 1476-5365. PMID 16862164. S2CID 31056997. " ... methylprednisolone and cyclosporine for acute graft-versus-host disease prophylaxis in allogeneic bone marrow transplantation ... Bhorade, S. M.; Stern, E. (2009-01-15). "Immunosuppression for Lung Transplantation". Proceedings of the American Thoracic ... Abdi, Reza; Spencer Martin; Steven Gabardi (2009). "Immunosuppressive Strategies in Human Renal Transplantation - Induction ...
Journal of Bone Marrow transplantation. Saba N.F, Goodman M, Ward K, Flowers C, Ramalingam S, Owonikoko T, Chen A, Grist W, ... Bone Marrow Transplantation. 24 (8): 853-855. doi:10.1038/sj.bmt.1702005. ISSN 1476-5365. PMID 10516696. Patel, P. R.; McDonald ... Bone Marrow Transplantation. 24 (8): 853-855. doi:10.1038/sj.bmt.1702005. ISSN 1476-5365. PMID 10516696. Saba, Nabil F.; ...
Research Institute of Bone Marrow Transplantation and Molecular Hematology and the A.A. Bogdanov Research Institute of Blood ...
... pioneer in bone-marrow transplantation for chronic myeloid leukaemia; founding Chairman of the charity Leuka Brian Greene, ...
1996) Established the Laminar Air Flow Room and the Bone Marrow Transplantation Center. (1995) The hospital is in walking ...
Bone, James; Rose, David (14 February 2009). "MMR scare doctor Andrew Wakefield makes fortune in US". The Times. London, UK. ... He continued his studies of small intestine transplantation under a Wellcome Trust travelling fellowship at University of ... Discordance with lymphocyte proliferative assays". Transplantation. 47 (3): 542-8. doi:10.1097/00007890-198903000-00028. PMID ... he was a member of a team that studied tissue rejection problems with small intestine transplantation, using animal models. ...
... are used to quantify and purify hematopoietic progenitor stem cells for research and for clinical bone marrow transplantation. ... Cells expressing CD34 (CD34+ cell) are normally found in the umbilical cord and bone marrow as haematopoietic cells, or in ... It may also mediate the attachment of hematopoietic stem cells to bone marrow extracellular matrix or directly to stromal cells ... Clinically, it is associated with the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Due to ...
The nearly intact bones of a woolly mammoth (Mammuthus primigenius) were discovered near the town of Kyle, Saskatchewan, where ... Jean Hamburger performed the first kidney transplantation from a deceased donor, after having pioneered kidney transplants in ... When the scraper blade on an earthmover exposed large bones, MacEvoy recognized its significance and work halted until the rest ...
... indicated for use in combination with filgrastim for mobilizing peripheral hematopoietic stem cells for later transplantation ... Bone Marrow Transplant. 34 (8): 683-91. doi:10.1038/sj.bmt.1704602. PMID 15322567. "{{Webarchive,url= ...
Furthermore, gene therapies and bone marrow transplantation may prove to be effective for certain lipid storage disorders. Diet ... and bone marrow. Inside cells under normal conditions, lysosomes convert, or metabolize, lipids and proteins into smaller ...
Lawson, Terry (January 1, 2000). "The Bone Collector". Detroit Free Press. Archived from the original on February 3, 2015. ... transplantations from a donor). Two years later, in March 2015, after annual test results indicated possible signs of early ... Jolie then co-starred with Denzel Washington in The Bone Collector (1999), playing a police officer who reluctantly helps ...
"Palmar Eccrine Hidradenitis Secondary to Trauma from Computer Gaming in an Adolescent After Bone Marrow Transplantation". ... "Inflammation of sites where tendons and ligaments are attached to the bone"), and epicondylitis (degeneration of the origin of ...
"Cause of atrioventricular block in patients after heart transplantation". Transplantation journal. "USC AGSA Dinner Dance and ... He was a board member of the Armenian American Chamber of Commerce, International Bone Marrow Donor Registry, President of the ... He co-authored a research article in the peer-reviewed journal Transplantation on "Cause of Atrioventricular Block in Patients ... After Heart Transplantation.". Armen continued his education at the USC Marshall School of Business and received his MBA in ...
1. Leukemia's: such as Acute Myelogenous Leukemia 2. Lymphomas: non hodking's Lymphoma, Lymph proliferative disease 3. Bone ... in order to support cord blood transplantations and related research in Singapore and around the world. SCBB is registered in ...
Bone, Brain and other organs scanning, Hormonal Assays and Viral Markings Speech & Language Therapy 24/7 Emergency Head & Spine ... Color Doppler and Ultrasonography Renal Transplantation and Renal Hemodialysis Radiotherapy Latest Physiotherapy Equipment, ...
Bone, Q. (2008). Biology of fishes. Richard H. Moore (3rd ed.). New York: Taylor & Francis. ISBN 978-0-203-88522-2. OCLC ... Cell Transplantation. 21 (9): 1997-2008. doi:10.3727/096368911X637452. PMID 22469297. S2CID 21603693. Zhao, Dawen; Richer, ...
Omrani AS, Almaghrabi RS (December 2017). "Complications of hematopoietic stem transplantation: Fungal infections". Hematology/ ... in long-term use there is a warning of the risk of bone fluorosis and periostitis especially in elderly patients. Additionally ... World Journal of Transplantation. 11 (9): 356-371. doi:10.5500/wjt.v11.i9.356. PMC 8465512. PMID 34631468. "Vfend loses its ... including people undergoing allogeneic bone marrow transplant (BMT), who have hematologic cancers or who undergo organ ...
"Allogeneic bone marrow transplantation for advanced Waldenstrom's macroglobulinemia". Bone Marrow Transplant. 23 (7): 747-9. ... A bone marrow biopsy provides a sample of bone marrow, usually from the lower back of the pelvis bone. The sample is extracted ... Autologous bone marrow transplantation is a treatment option. Zanubrutinib is indicated for the treatment of adults with ... "High-dose chemotherapy followed by stem cell transplantation in patients with resistant Waldenstrom's macroglobulinemia". Bone ...
Allogenic bone marrow transplantation has been investigated in the treatment of HTLV-1 disease with varied results. One case ... She was subsequently treated with allogenic stem cell transplantation and had complete resolution of symptoms. One year post- ...
The drug was noted to increase the risk of veno-occlusive disease in the absence of bone marrow transplantation. Later the ... onset of VOD was shown to occur at increased frequency in gemtuzumab patients even following bone marrow transplantation. The ... suppressed activity of bone marrow, which is involved in formation of various blood cells [found in 98% of patients]), disorder ... therapy is associated with hepatic venoocclusive disease in patients who have not received stem cell transplantation". Cancer. ...
... developed in bone marrow, secretes a specific antibody in response to an encounter with a specific foreign antigen Mitchell ... pioneer of modern heart transplantation Robert Clancy - developer of first oral vaccine for acute bronchitis Graeme Clark FRS ...
"Organ Transplantation in India". Retrieved 29 April 2020. "The Andhra Pradesh Transplantation of Human Organs Act, 1995" (PDF ... After a natural cardiac death, organs that can be donated are cornea, bone, skin, and blood vessels, whereas after brainstem ... Organ transplantation is a medical procedure where one organ removed from one person and placed in the body of recipient. Vital ... The Andhra Pradesh Transplantation of Human Organs Act, 1995, was enacted by the government shortly after the central act. The ...
Immune system aging in mice can be partly restricted by restoring thymus growth, which can be achieved by transplantation of ... "Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice ...
The extracavitary tumors may develop in lymph nodes, bone, bone marrow, the gastrointestinal tract, skin, spleen, liver, lungs ... prior organ transplantation, the decline in immunity that develops with aging, and/or cirrhosis of the liver due to hepatitis B ... and/or rarely of immune deficiency due to organ transplantation, hepatitis complicated by cirrhosis caused by hepatitis B or C ...
... of JAK3 deficiency in a patient with severe combined immunodeficiency over 20 years after bone marrow transplantation: ...
Myelokathexis is impaired escape of mature neutrophils from bone marrow, causing neutropenia. Patients with WHIM syndrome have ... One emerging therapy is hematopoietic stem cell transplantation, which has been considered standard treatment for many combined ...
Then he sutured them together and attached them to the stump of bone to keep them from retracting. This is the first known hand ... 2008). "Hand Transplantation: The Innsbruck Experience". Transplantation of Composite Tissue Allografts. pp. 234-250. doi: ... Hand transplantation is a surgical procedure to transplant a hand from one human to another. The donor hand usually comes from ... On October 26, 2016, the Director of hand transplantation at UCLA, Dr. Kodi Azari, and his team, performed a hand transplant on ...
To diagnose Pearson Syndrome a physician can either collect a bone marrow biopsy and look for sideroblastic anemia, a symptom ... Single Dose Clinical Study to Evaluate the Safety and Therapeutic Effects of Transplantation of MNV-BM-BLD (Autologous cd34+ ... With Pearson syndrome, the bone marrow fails to produce white blood cells called neutrophils. The syndrome also leads to anemia ... Specifically, Pearson syndrome is a combination of syndromes that involves the bone marrow and the exocrine pancreas. Pearson ...
... and chewed bones. After the arrival of Guru Rinpoche in the eighth century, he stopped the people from eating flesh and ... Nephrology Dialysis Transplantation. 17 (5): 708-714. doi:10.1093/ndt/17.5.708. PMID 11981051 - via Oxford Academic. ...
Bone marrow transplantation replaces faulty bone marrow with healthy bone marrow from a donor. Learn about the possible risks, ... Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, ... Bone marrow (stem cell) donation (Medical Encyclopedia) Also in Spanish * Bone marrow transplant (Medical Encyclopedia) Also in ... Bone marrow transplantation has serious risks. Some complications can be life-threatening. But for some people, it is the best ...
Thomas, a hematologist who earned a Nobel Prize in 1990 for establishing bone marrow transplantation as a successful treatment ... Thomas and others, the NHLBI supports research in bone marrow transplantation and stem cell biology, including through the ... Today, bone marrow and blood stem cell transplants are performed to treat or cure blood cancers and certain immune conditions ... reactions known as graft-versus-host disease by using the drug methotrexate-thus showing that bone marrow transplantation could ...
Bone grafts may be procured from the recipients own bone (autograft) or from either living donors who are having bone removed ... transmission by bone transplantation. Also, the recipient is the first person reported to CDC as having transplantation- ... of bone autografts will reduce the risk of HIV transmission by bone transplantation. ... Allograft bone obtained from the hospital bone bank was used in the procedure. The recipient was seen by a physician 21 days ...
RESEARCH OBJECTIVES Background Bone marrow transplantation offers potentially curative treatment for a growing number of ... For example, inbred strains might be used to learn about genetic determinants of post bone marrow transplantation lung injury, ... Full Text HL-95-002 MECHANISMS OF POST BONE MARROW TRANSPLANTATION LUNG INJURY NIH GUIDE, Volume 23, Number 33, September 16, ... This Request for Applications (RFA), Mechanisms of Post Bone Marrow Transplantation Lung Injury, is related to the priority ...
Bone Marrow Transplantation, Hemoglobinopathies, SCALLOP (SCALLOP). The safety and scientific validity of this study is the ... they will be given bone marrow from a brother or sister who has healthy bone marrow that matches the patients. The healthy bone ... If the donor bone marrow does not grow, we will thaw the stored marrow and put it back into the body. This stored bone marrow ... We would like to treat patients using bone marrow transplantation, a treatment that has been used for people with SCD. The ...
TRACO: Leukemias, Bone Marrow Transplantation
We have studied liver status before and after bone marrow transplantation in 43 consecutiv … ... Liver dysfunction occurs after bone marrow transplantation but the relative importance of graft versus host disease and other ... Liver disease after bone marrow transplantation M J Farthing, M L Clark, J P Sloane, R L Powles, T J McElwain ... Liver disease after bone marrow transplantation M J Farthing et al. Gut. 1982 Jun. ...
Pulmonary function after bone marrow transplantation for chronic myeloid leukaemia. Message subject: (Your Name) has forwarded ...
... successfully treated by cord blood stem cell transplantation (CBSCT) from an unrelated donor. He had recurrent life-threatening ... Bone Marrow Transplantation (Bone Marrow Transplant) ISSN 1476-5365 (online) ISSN 0268-3369 (print) ... Bone Marrow Transplantation volume 33, pages 969-971 (2004)Cite this article ... Mino, E., Kobayashi, R., Yoshida, M. et al. Umbilical cord blood stem cell transplantation from unrelated HLA-matched donor in ...
WHAT IS BONE MARROW?. Are you still thinking bone marrow and spinal cord are the same? Youre very wrong. Find out more about ... Here we can read the new PATIENTS BONE MARROW TRANSPLANTATION GUIDE (Available in Spanish) ...
... allogeneic bone marrow transplantation Procedure: autologous bone marrow transplantation Procedure: peripheral blood stem cell ... Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and ... MedlinePlus related topics: Acute Myeloid Leukemia Bone Marrow Transplantation Leukemia Genetic and Rare Diseases Information ... Compare 4 vs 5 courses of total treatment, with either chemotherapy or bone marrow transplantation (BMT) as the final course, ...
Systemic fungal infections are a major problem in bone marrow transplant recipients who have prolonged neutropenia or who ... vs low-dose amphotericin B for the prevention of fungal infections in patients undergoing bone marrow transplantation: a study ... Use of liposomal amphotericin B in bone marrow transplant. Sastry PS, Parikh PM, Kulkarni PS, Bhagwat R, Gadade H. Sastry PS, ... Timmers GJ, Zweegman S, Simoons-Smit AM, van Loenen AC, Touw D, Huijgens PC. Timmers GJ, et al. Bone Marrow Transplant. 2000 ...
Allogeneic bone marrow transplantation for STAT3 deficiency. Thursday, September 13, 2018. - Poster Session III ... Patients with STAT3 deficiency are infrequently offered allogeneic bone marrow transplantation (alloBMT), as many are managed ... All patients received reduced-intensity conditioning, a T-cell-replete bone marrow graft (1 HLA-haploidentical, 2 HLA-matched ...
Ex vivo spermine dialdehyde treatment prevents lethal GVHD in a murine bone marrow transplantation model. ... Ex vivo spermine dialdehyde treatment prevents lethal GVHD in a murine bone marrow transplantation model. Journal Article ( ... SDA may have clinical application as a purging agent in allogeneic bone marrow transplantation. ... In this model, lethally irradiated C3H (H-2k) mice received BALB/c (H-2d) bone marrow and spleen cell mixtures which had been ...
Allogeneic bone marrow transplantation for Alexanders disease. In: Bone Marrow Transplantation. 1997 ; Vol. 20, No. 3. pp. 247 ... Allogeneic bone marrow transplantation for Alexanders disease. Bone Marrow Transplantation. 1997 Aug 1;20(3):247-249. doi: ... Allogeneic bone marrow transplantation for Alexanders disease, Bone Marrow Transplantation, vol. 20, no. 3, pp. 247-249. ... Allogeneic bone marrow transplantation for Alexanders disease. / Staba, M. J.; Goldman, S.; Johnson, F. L. et al. In: Bone ...
... sponge-like material found inside bones. It contains immature cells known as hematopoietic or blood-forming stem cells. Hemato ... Bone Marrow Collection For Transplantation Top Open Access Journals. Bone marrow is the soft, sponge-like material found inside ... Most hematopoietic stem cells are found in the bone marrow, but some cells, called peripheral blood stem cells (PBSCs), are ... Journal of Bone Research received 237 citations as per Google Scholar report ...
... Some Hospital-Acquired Infections Traced to Patients Own Microbiome Posted on October 23rd, ... Tags: bone marrow transplantation, chromosomal shattering, chromosome, chromothripsis, CRISPR-Cas, immunodeficiency, rare ... Tags: antibiotic resistance, bacteria, bloodstream infections, bone marrow transplantation, computational biology, E. coli, ... bone marrow transplantation, cell reprogramming, endothelial cells, graft versus host disease, hematopoietic stem cells, HSC, ...
Bone substitutes in tooth transplantations]. Team: Biology of Host-parasite Interactions. Member: Didier Ménard ...
Bone marrow transplantation. In patients with severe thalassemia intermedia who require aggressive therapy to sustain life, ... Bone quality in beta-thalassemia intermedia: relationships with bone quantity and endocrine and hematologic variables. Ann ... bone marrow transplantation, similar to that performed in patients with thalassemia major, is a reasonable alternative to ... Division of Hematology/Oncology and Bone Marrow Transplantation, Associate Chairman for Education, Department of Pediatrics, ...
Nodular regenerative hyperplasia of the liver following bone marrow transplantation. Dale C. Snover, Sally Weisdorf, Joseph ... Dive into the research topics of Nodular regenerative hyperplasia of the liver following bone marrow transplantation. ...
... a damaged heart with stem cells offers immense promise and British scientists look forward to the day when transplantation ... Bone Marrow Transplantation. Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are ... Bone Marrow Transplantation - Animation. Animation and slides providing graphic explanation of Bone Marrow Transplantation (BMT ... Repairing A Damaged Heart With Stem Cells may Relegate the Need for Transplantation Surgeries Personalised Printable Document ( ...
possibly during this free Bone Marrow Transplantation, they exist nt adorned to be already from the understanding where they ... Free Bone Marrow Transplantation (Vademecum) 1996. Free Bone Marrow Transplantation (Vademecum) 1996. by Valentine 4.5 ... 39; free Bone Marrow Transplantation check thoughts we are captured or made until we note. 39;, almost foreign but it is left. ... free Bone Marrow Transplantation (Vademecum) operas may create be FDI but have not negative However when minutes offer shifting ...
Covid-19 containment measures adopted in bone marrow transplantation service. Covid-19 containment measures adopted in bone ... in the care of patients undergoing hematopoietic stem cell transplantation to avoid COVID-19. METHODS:. Experience report. ... such as the reduction in the number of hospitalizations for transplantation, clinical screening of outpatients entering the ... marrow transplantation service. Rodrigues, Jéssica Alline Pereira; Stelmatchuk, Alzira Maria; Lacerda, Maria Ribeiro; Galvão, ...
Palavras-chave : bone marrow transplantation; occupation; vocational rehabilitation; occupational therapy. · resumo em ... The aim of this prospective study was to describe the changes in the occupational status of 62 Bone Marrow Transplantation (BMT ... Occupational life of patients surviving a bone marrow transplantation: Exploratory study. Rev. bras. orientac. prof [online]. ...
The NIH Bone Marrow Stromal Cell Transplantation Center. Description of Collaborative Activity:. The mission of the NIH Bone ... Transplantation is to develop clinical grade bone marrow stromal cells for use in clinical trials that utilizes the ability of ...
Transplantation, Heterologous. Bone Transplantation. Leg Bones -- transplantation 4. The transplantation of bone: with two ... Bone Transplantation 3. Transplantation of tissue from lower animals to man: and a report of the case of bone-transplantation ... Bone Transplantation. Fractures, Bone -- surgery 2. The Living bone graft Author(s): Weiland, Andrew J. Publication: [Baltimore ... Start Over You searched for: Subjects Bone Transplantation ✖Remove constraint Subjects: Bone Transplantation ...
Researchers testing the effects of two bone act ... The results point to the value of treating bone loss in ... Alendronate versus calcitriol for the prevention of bone loss after cardiac transplantation. NEJM 2004;350(8):767-776. ... "The bottom line," says Joan McGowan, Ph.D., chief of the NIAMS Musculoskeletal Diseases Branch, "is that drugs to prevent bone ... No significant difference in either bone loss or fracture rate was found between the two treatment groups, and both drug groups ...
Bone Marrow Transplantation * Bone Transplantation see Bone Grafts * Cord Blood see Stem Cells ...
Bone Marrow Transplantation Failure or Engraftment Delay. The recommended dose is 250 mcg/m2/day for 14 days as a 2-hour IV ... Autologous Bone Marrow Transplantation7 Following a dose-ranging Phase I/II trial in patients undergoing autologous BMT for ... Use in Bone Marrow Transplantation Failure or Engraftment Delay LEUKINE is indicated in patients who have undergone allogeneic ... Autologous and Allogeneic Bone Marrow Transplantation LEUKINE is generally well tolerated. In three placebo-controlled studies ...
Uncertainty in pediatric bone marrow transplantation: A qualitative analysis about parents perspective ...
  • Histopathological changes in the liver after allogeneic bone marrow transplantation. (
  • Patients with STAT3 deficiency are infrequently offered allogeneic bone marrow transplantation (alloBMT), as many are managed with supportive care and antibiotic prophylaxis alone. (
  • Spermine dialdehyde (SDA), an oxidized product of spermine which irreversibly suppresses T cell and NK cell activities, was evaluated as an ex vivo purging agent in the prevention of graft-versus-host disease (GVHD) in mice transplanted with SDA-treated allogeneic bone marrow. (
  • SDA may have clinical application as a purging agent in allogeneic bone marrow transplantation. (
  • In this case report, we evaluate the efficacy of allogeneic bone marrow transplantation (BMT) in a 7-month-old female with the infantile form of Alexander's disease. (
  • Increasing age has been historically implicated in higher mortality after high-dose allogeneic HCT for patients with hematologic malignancies [cancers of the blood or bone marrow]. (
  • To address this limitation, a nonmyeloablative (an approach using lower doses of chemotherapy and/or radiation that does not lead to eradication of all bone marrow cells prior to stem cell transplant) conditioning regimen for allogeneic HCT was developed. (
  • Many studies of allogeneic marrow transplantation have shown that a higher dose of marrow cells correlates with a stronger hematopoietic engraftment and lower mortality from infectious complications. (
  • Treatment for patients with thalassemia major includes long-term transfusion therapy, iron chelation, splenectomy, allogeneic hematopoietic stem cell transplantation, gene therapy, and supportive measures. (
  • Read more about the lasting impact of Dr. Thomas' work in a 1997 New England Journal of Medicine article, Hematopoietic-Cell Transplantation at 50 . (
  • Most hematopoietic stem cells are found in the bone marrow, but some cells, called peripheral blood stem cells (PBSCs), are found in the bloodstream. (
  • To address this challenge, researchers have been trying to develop reliable, lab-based methods for making the vital, blood-producing component of bone marrow: hematopoietic stem cells (HSCs). (
  • To describe the experience of nursing , in adopting containment measures , in the care of patients undergoing hematopoietic stem cell transplantation to avoid COVID-19. (
  • In vitro exposure of human bone marrow cells to LEUKINE at concentrations ranging from 1-100 ng/mL results in the proliferation of hematopoietic progenitors and in the formation of pure granulocyte, pure macrophage and mixed granulocytemacrophage colonies. (
  • We would like to treat patients using bone marrow transplantation, a treatment that has been used for people with SCD. (
  • Currently, very little has been reported about organ function after bone marrow transplants in patients with sickle cell anemia. (
  • We have studied liver status before and after bone marrow transplantation in 43 consecutive patients and have related this to survival and factors that are recognised to cause liver injury. (
  • Minor abnormalities of liver tests occurred in 21% of patients before grafting but this did not influence survival or the development of liver disease after transplantation. (
  • Stem cell transplantation in patients with severe congenital neutropenia without evidence of leukemic transformation. (
  • Compare 4 vs 5 courses of total treatment, with either chemotherapy or bone marrow transplantation (BMT) as the final course, with respect to remission duration, relapse rate, disease free mortality, and overall survival in these patients. (
  • All patients received reduced-intensity conditioning, a T-cell-replete bone marrow graft (1 HLA-haploidentical, 2 HLA-matched related), and post-transplant cyclophosphamide-based graft-versus-host disease (GVHD) prophylaxis. (
  • In a study of 30 bone-marrow transplant patients suffering from bloodstream infections, researchers used a newly developed computational tool called StrainSifter to match microbial DNA from close to one-third of the infections to bugs already living in the patients' large intestines [1]. (
  • Bone marrow transplants offer a way to cure leukemia, sickle cell disease, and a variety of other life-threatening blood disorders.There are two major problems, however: One is many patients don't have a well-matched donor to provide the marrow needed to reconstitute their blood with healthy cells. (
  • and also the local measures implemented in the health service , such as the reduction in the number of hospitalizations for transplantation , clinical screening of outpatients entering the service, monitoring of respiratory signs and symptoms , the allocation of specific isolation rooms for those suspected of the disease and testing of symptomatic patients . (
  • The results point to the value of treating bone loss in transplant patients. (
  • Elizabeth Shane, M.D., of the Columbia University College of Physicians and Surgeons in New York, and her colleagues there and at the Newark-Beth Israel Medical Center in New Jersey conducted a randomized trial involving 149 patients in whom either alendronate or calcitriol was begun within the first few weeks after heart transplantation. (
  • The results were compared with those from a reference group of 27 patients who had undergone transplantation during the same time period. (
  • The bottom line," says Joan McGowan, Ph.D., chief of the NIAMS Musculoskeletal Diseases Branch, "is that drugs to prevent bone loss should be considered in all transplant patients. (
  • receipt of bone marrow or stem cells transplant) had survival and progression-free survival outcomes suggesting that this treatment approach may be a viable option for older patients with these malignancies, according to a scientific study. (
  • Prior to their participation in this study, patients will undergo the following evaluations: a physical exam, blood work, breathing tests, heart-function tests, chest and sinus x-rays, and bone-marrow sampling. (
  • To compare survival rates of patients with hematologic cancers that received transplantation of granulocyte colony stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSC) versus marrow from HLA-compatible unrelated donors. (
  • In our case, the patients were treated with wide resection of the bone segment. (
  • Although we verified the safety of the autologous bone marrow stem cell transplantation in sensorineural hearing loss patients but we could not achieve significant improvement in hearing. (
  • From these research results, we tried transplantation of MSCs in patients with sensorineural hearing loss. (
  • The NHLBI joins the rest of the scientific community in mourning the loss of a true pioneer, E. Donnall Thomas, M.D. Dr. Thomas, a hematologist who earned a Nobel Prize in 1990 for establishing bone marrow transplantation as a successful treatment for leukemia and other blood conditions, died Oct. 20 at the age of 92. (
  • Animation and slides providing graphic explanation of Bone Marrow Transplantation (BMT)/Stem Cell Transplantation that is done for leukemia and other blood-related disorders. (
  • Eligible subjects were less than 66 years of age and were planning to undergo transplantation for acute leukemia, myelodysplasia, chronic myeloid or myelomonocytic leukemia, or myelofibrosis. (
  • Sargramostim is a colony stimulating factor that is FDA approved for the treatment of granulocytopenia following induction chemotherapy in acute myelogenous leukemia , mobilization and following transplantation of autologous peripheral blood progentior cells, myeloid reconstitution after autologous bone marrow transplantation, myeloid reconstitution after allogeneic bone marrow transplantation and bone marrow transplantation failure or engraftment delay. (
  • Dr. Thomas recognized the importance of matching donors to recipients, helped determine the best way to suppress the immune system before transplantation, exploited the graft-versus-tumor effect whereby donor cells recognize and help eliminate cancer, and reduced severe reactions known as graft-versus-host disease by using the drug methotrexate-thus showing that bone marrow transplantation could be a viable treatment option for certain life-threatening diseases. (
  • The recipient had no known risk for HIV infection other than the bone grafting procedure, and the bone donor was subsequently found to have been infected with HIV. (
  • The bone donor was a 52-year-old man who had donated his left femoral head, which was excised during a hip arthroplasty procedure performed for degenerative joint disease in November 1984. (
  • We report here a 6-month-old boy with severe congenital neutropenia (SCN) successfully treated by cord blood stem cell transplantation (CBSCT) from an unrelated donor. (
  • A much more powerful option would be to develop a means for every patient to serve as their own bone marrow donor. (
  • Are you still thinking bone marrow and spinal cord are the same? (
  • Recently, many studies revealed that mesenchymal stem cells from umbilical cord blood (UCB) or Bone marrow (BM) can differentiate into multiple lineage cells. (
  • Today, bone marrow and blood stem cell transplants are performed to treat or cure blood cancers and certain immune conditions and blood diseases. (
  • Pulmonary function after bone marrow transplantation for chronic myeloid leukaemia. (
  • When a minimum number of bone marrow cells were used for reconstitution, SDA-treated marrow reconstituted lethally irradiated mice as effectively as control marrow suggesting that SDA had little impact on early myeloid cells which are required for engraftment. (
  • Building on the legacy of Dr. Thomas and others, the NHLBI supports research in bone marrow transplantation and stem cell biology, including through the Blood and Marrow Transplant Clinical Trials Network , with the goal of treating and even curing more diseases through transplantation. (
  • The stem cell, now without the disease-causing gene, repopulated her immune system with healthy bone marrow-derived immune cells, resulting in cure of the syndrome. (
  • Subjects were randomly assigned in a 1:1 ratio to peripheral-blood stem-cell or bone marrow transplantation, stratified according to transplantation center and disease risk. (
  • There was no detected significant survival differences between peripheral-blood stem-cell and bone marrow transplantation from unrelated donors. (
  • Stem cell transplantation represents a promising therapy for several degenerating and necrotic diseases. (
  • In spite of mesenchymal stem cell (MSC) transplantation has not been tried for hearing loss yet, MSCs have been applied to many other organ disorders like hematological disorders, cardiovascular disease, osteogenesis imperfecta, some neurological pathologies and even cancer. (
  • Peripheral blood stem cells (PBSC) collected after mobilization with granulocyte colony stimulating factor (G-CSF) contain a large number of CD34-positive progenitors and total cells than bone marrow. (
  • Further analysis indicated that peripheral-blood stem cells may reduce the risk of graft failure, whereas bone marrow may reduce the risk of chronic GVHD. (
  • This Request for Applications (RFA), Mechanisms of Post Bone Marrow Transplantation Lung Injury, is related to the priority areas of immunization and infectious diseases and cancer. (
  • Previous hepatitis and androgen therapy could not be implicated as important causes of hepatic damage but chemotherapy for acute leukaemia and conditioning regimens for bone marrow transplantation appear to be the most important factors in the development of hepatic veno-occlusive disease. (
  • Combining chemotherapy with bone marrow transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. (
  • The recommended dose is 250 mcg/m2/day administered IV over a 2-hour period beginning two to four hours after bone marrow infusion, and not less than 24 hours after the last dose of chemotherapy or radiotherapy. (
  • Bone grafts can be used to achieve this. (
  • According to the myocardial infarction, some articles revealed MSC transplantation has more benefit in increasing left ventricular ejection fraction and systolic wall motion [ 7 ]. (
  • Secondary end points included post-transplantation incidences of neutrophil and platelet engraftment, graft failure, acute and chronic GVHD, relapse, and infections. (
  • Liver dysfunction occurs after bone marrow transplantation but the relative importance of graft versus host disease and other factors, such as infection, radiation, and drugs, has not been clearly established. (
  • However, some studies have also shown increased risk of acute and chronic graft-versus-host disease (GVHD), as compared to bone marrow. (
  • Cord blood is rich in stem cells (cells produced in the bone marrow that mature to different types of blood cells), which may prove useful in new sickle cell therapies. (
  • A bone marrow transplant is a procedure that replaces a person's faulty bone marrow stem cells. (
  • What Is a Bone Marrow Transplant? (
  • In February 1988, a bone transplant recipient was diagnosed with acquired immunodeficiency syndrome (AIDS) after being found positive for antibody to human immunodeficiency virus (HIV) and developing Pneumocystis carinii pneumonia (PCP). (
  • The transplant uses healthy 'matched' bone marrow. (
  • Systemic fungal infections are a major problem in bone marrow transplant recipients who have prolonged neutropenia or who receive high-dose corticosteroids. (
  • Researchers testing the effects of two bone active drugs in heart transplant recipients have found that both reduce the degree of bone loss commonly seen in the first year following transplant surgery. (
  • Transplant recipients are at high risk for osteoporosis, a skeletal disorder marked by reduced bone strength and fractures, because of the drugs they must take to prevent the body's rejection of the transplanted organ. (
  • It is hoped that this will bring more attention to post-transplant bone loss and its prevention. (
  • modern free Bone Marrow Transplantation (Vademecum) 1996, Gopher A, Galili E, Hershkovitz I. Musculoskeletal book boas in big sources and joint sections in the Levant: the Quaternary subsistence. (
  • temporal photos free Bone Marrow Transplantation (Vademecum) 1996 for their salvation illegal certificate sex females, but we come consistently that you can improve compensate at a magisterial political g. threatening through a block of books can do a original ride, but when you use our scans on your browser you will have the best Unemployment to revel jS from reply human website content! (
  • Allografts are taken from donors or cadavers and they serve as alternatives to autograft in bone reconstruction. (
  • Previous reports have identified transmission of HIV through transplantation of kidney, liver, heart, pancreas (1-3), possibly by skin (4), and by artificial insemination (5), but none of these infected recipients have been reported as having developed AIDS. (
  • This study investigated the putative immunemodulatory effects in neuroinflammation of systemic transplantation of MSC into APP/PS1 transgenic mice. (
  • Because the cell therapy uses a patient's own cells, it negates the risks or complications associated with other treatment options such as rejection linked to transplantation," Boon added. (
  • Autogenous bone is generally used as an optimal graft because it integrates faster and with fewer complications. (
  • Allograft bone obtained from the hospital bone bank was used in the procedure. (
  • This type BMT procedure is described as nonmyeloablative, meaning that it does not destroy the patient s bone marrow. (
  • Long-term results of allograft replacement in the management of bone tumors. (
  • Intercalary allograft reconstructions following resection of primary bone tumors: a nationwide multicenter study. (
  • Based on research that describes Alexander's disease as a leukodystrophy which may result from an unidentified enzyme deficiency, we attempted marrow transplantation to reverse or arrest the patient's neurological deterioration. (
  • The trial was difficult to conduct and monitor because of the serious medical conditions involved and the lack of control over the many drugs and interventions related to the transplantation. (
  • Alanine transaminase was significantly higher in non-survivors and appeared to predict survival early after transplantation. (
  • Researchers say the chromosomal shattering probably took place in a cell in the bone marrow. (
  • In July 1986, 20 months after receiving the bone allograft, the recipient was evaluated again when she complained of enlarged axillary lymph nodes that she had found during a breast self-examination. (
  • Allograft Transplantation and Reconstruction of Bones after Malignant Tumor Resections. (
  • Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. (
  • The standard in bone grafting consists of tissue harvested from the patient, autograft, usually from the iliac crest or distal femur and tibia. (
  • After resection of a large piece of bone, limb reconstruction (when is necessary) can be easily achieved with mechanical reconstruction with metallic prosthesis, or biological reconstruction with bone. (
  • Ex vivo spermine dialdehyde treatment prevents lethal GVHD in a murine bone marrow transplantation model. (
  • No significant difference in either bone loss or fracture rate was found between the two treatment groups, and both drug groups showed reduced bone loss compared to the reference group. (
  • Recently, transplantation of stem cells has emerged as a promising therapeutic option for the treatment of intractable hearing loss [ 5 ]. (
  • This destroys the faulty stem cells in your bone marrow. (
  • In some cases, you can donate your own bone marrow stem cells in advance. (
  • A new method to repair a damaged heart with stem cells offers immense promise and British scientists look forward to the day when transplantation surgeries may not be necessary. (
  • The drug alendronate, however, which reduces the activity of cells that cause bone loss, was judged to be more clinically useful than calcitriol, a synthetic substance similar to vitamin D, which helps regulate calcium metabolism in the body. (