Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
The physiological renewal, repair, or replacement of tissue.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Procedures for enhancing and directing tissue repair and renewal processes, such as BONE REGENERATION; NERVE REGENERATION; etc. They involve surgically implanting growth conducive tracks or conduits (TISSUE SCAFFOLDING) at the damaged site to stimulate and control the location of cell repopulation. The tracks or conduits are made from synthetic and/or natural materials and may include support cells and induction factors for CELL GROWTH PROCESSES; or CELL MIGRATION.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
The process of bone formation. Histogenesis of bone including ossification.
Renewal or physiological repair of damaged nerve tissue.
Repair or renewal of hepatic tissue.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
Diseases of BONES.
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
A preparation consisting of PLATELETS concentrated in a limited volume of PLASMA. This is used in various surgical tissue regeneration procedures where the GROWTH FACTORS in the platelets enhance wound healing and regeneration.
The grafting of bone from a donor site to a recipient site.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
Techniques for enhancing and directing cell growth to repopulate specific parts of the PERIODONTIUM that have been damaged by PERIODONTAL DISEASES; TOOTH DISEASES; or TRAUMA, or to correct TOOTH ABNORMALITIES. Repopulation and repair is achieved by guiding the progenitor cells to reproduce in the desired location by blocking contact with surrounding tissue by use of membranes composed of synthetic or natural material that may include growth inducing factors as well.
Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.
Bone loss due to osteoclastic activity.
Artificial substitutes for body parts and materials inserted into organisms during experimental studies.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
The physiological restoration of bone tissue and function after a fracture. It includes BONY CALLUS formation and normal replacement of bone tissue.
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
Tumors or cancer located in bone tissue or specific BONES.
Bone lengthening by gradual mechanical distraction. An external fixation device produces the distraction across the bone plate. The technique was originally applied to long bones but in recent years the method has been adapted for use with mandibular implants in maxillofacial surgery.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Restoration of integrity to traumatized tissue.
Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.
Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC
Submicron-sized fibers with diameters typically between 50 and 500 nanometers. The very small dimension of these fibers can generate a high surface area to volume ratio, which makes them potential candidates for various biomedical and other applications.
Nanometer-scale composite structures composed of organic molecules intimately incorporated with inorganic molecules. (Glossary of Biotechnology and Nanobiotechology Terms, 4th ed)
A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.
A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.
Biocompatible materials placed into (endosseous) or onto (subperiosteal) the jawbone to support a crown, bridge, or artificial tooth, or to stabilize a diseased tooth.
Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.
Hemorrhage into a canal or cavity of the body, such as the space covered by the serous membrane (tunica vaginalis) around the TESTIS leading to testicular hematocele or scrotal hematocele.
The air space located in the body of the MAXILLARY BONE near each cheek. Each maxillary sinus communicates with the middle passage (meatus) of the NASAL CAVITY on the same side.
Products made by baking or firing nonmetallic minerals (clay and similar materials). In making dental restorations or parts of restorations the material is fused porcelain. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Boucher's Clinical Dental Terminology, 4th ed)
The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.
Fractures of the skull which may result from penetrating or nonpenetrating head injuries or rarely BONE DISEASES (see also FRACTURES, SPONTANEOUS). Skull fractures may be classified by location (e.g., SKULL FRACTURE, BASILAR), radiographic appearance (e.g., linear), or based upon cranial integrity (e.g., SKULL FRACTURE, DEPRESSED).
Injuries to the lower jaw bone.
A biocompatible polymer used as a surgical suture material.
Intraoral OSTEOTOMY of the lower jaw usually performed in order to correct MALOCCLUSION.
Fractures of the lower jaw.
The bony deposit formed between and around the broken ends of BONE FRACTURES during normal healing.
A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Breaks in bones.
Insertion of an implant into the bone of the mandible or maxilla. The implant has an exposed head which protrudes through the mucosa and is a prosthodontic abutment.
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The thickest and spongiest part of the maxilla and mandible hollowed out into deep cavities for the teeth.
A group of phosphate minerals that includes ten mineral species and has the general formula X5(YO4)3Z, where X is usually calcium or lead, Y is phosphorus or arsenic, and Z is chlorine, fluorine, or OH-. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A continuous protein fiber consisting primarily of FIBROINS. It is synthesized by a variety of INSECTS and ARACHNIDS.
Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.
Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)
Tumors or cancer of the MANDIBLE.
A hollow part of the alveolar process of the MAXILLA or MANDIBLE where each tooth fits and is attached via the periodontal ligament.
Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.
A plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. The seed of Ricinus communis L. is the CASTOR BEAN which is the source of CASTOR OIL; RICIN; and other lectins.
The grafting or inserting of a prosthetic device of alloplastic material into the oral tissue beneath the mucosal or periosteal layer or within the bone. Its purpose is to provide support and retention to a partial or complete denture.
Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.
Materials fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems.
A CCN protein family member found at high levels in NEPHROBLASTOMA cells. It is found both intracellularly and in the EXTRACELLULAR MATRIX and may play a role in the regulation of CELL PROLIFERATION and EXTRACELLULAR MATRIX synthesis.
Elements of limited time intervals, contributing to particular results or situations.
Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.
Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.
Nonparasitic free-living flatworms of the class Turbellaria. The most common genera are Dugesia, formerly Planaria, which lives in water, and Bipalium, which lives on land. Geoplana occurs in South America and California.
Excision of all or part of the liver. (Dorland, 28th ed)
A dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)
Fractures of the femur.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
A network of cross-linked hydrophilic macromolecules used in biomedical applications.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Silicon polymers that contain alternate silicon and oxygen atoms in linear or cyclic molecular structures.
Preprosthetic surgery involving rib, cartilage, or iliac crest bone grafts, usually autologous, or synthetic implants for rebuilding the alveolar ridge.
Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.
A highly glycosylated and sulfated phosphoprotein that is found almost exclusively in mineralized connective tissues. It is an extracellular matrix protein that binds to hydroxyapatite through polyglutamic acid sequences and mediates cell attachment through an RGD sequence.
Propylene or propene polymers. Thermoplastics that can be extruded into fibers, films or solid forms. They are used as a copolymer in plastics, especially polyethylene. The fibers are used for fabrics, filters and surgical sutures.
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
An immature epithelial tumor of the JAW originating from the epithelial rests of Malassez or from other epithelial remnants of the ENAMEL from the developmental period. It is a slowly growing tumor, usually benign, but displays a marked propensity for invasive growth.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
The fibrous CONNECTIVE TISSUE surrounding the TOOTH ROOT, separating it from and attaching it to the alveolar bone (ALVEOLAR PROCESS).
The maximum compression a material can withstand without failure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p427)
Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
A family of Urodela consisting of 15 living genera and about 42 species and occurring in North America, Europe, Asia, and North Africa.
The farthest or outermost projections of the body, such as the HAND and FOOT.
Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A salamander found in Mexican mountain lakes and accounting for about 30 percent of the urodeles used in research. The axolotl remains in larval form throughout its life, a phenomenon known as neoteny.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Cells with high proliferative and self renewal capacities derived from adults.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Treatment of muscles and nerves under pressure as a result of crush injuries.
Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.
A mutant strain of Rattus norvegicus without a thymus and with depressed or absent T-cell function. This strain of rats may have a small amount of hair at times, but then lose it.
Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from:
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS. It regulates BONE MORPHOGENETIC PROTEIN signaling and is essential for PHYSIOLOGICAL ANGIOGENESIS.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
A species of newt in the Salamandridae family in which the larvae transform into terrestrial eft stage and later into an aquatic adult. They occur from Canada to southern United States. Viridescens refers to the greenish color often found in this species.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
The surgical removal of a tooth. (Dorland, 28th ed)
Membranous appendage of fish and other aquatic organisms used for locomotion or balance.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Premature closure of one or more CRANIAL SUTURES. It often results in plagiocephaly. Craniosynostoses that involve multiple sutures are sometimes associated with congenital syndromes such as ACROCEPHALOSYNDACTYLIA; and CRANIOFACIAL DYSOSTOSIS.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
The flexible rope-like structure that connects a developing FETUS to the PLACENTA in mammals. The cord contains blood vessels which carry oxygen and nutrients from the mother to the fetus and waste products away from the fetus.
Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.
A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.
Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Elongated, spindle-shaped, quiescent myoblasts lying in close contact with adult skeletal muscle. They are thought to play a role in muscle repair and regeneration.
Characteristics or attributes of the outer boundaries of objects, including molecules.
Compounds based on fumaric acid.
Repair of the damaged neuron function after SPINAL CORD INJURY or SPINAL CORD DISEASES.
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Surgical insertion of a prosthesis.
Numerical expression indicating the measure of stiffness in a material. It is defined by the ratio of stress in a unit area of substance to the resulting deformation (strain). This allows the behavior of a material under load (such as bone) to be calculated.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Introduction of substances into the body using a needle and syringe.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
Methods for maintaining or growing CELLS in vitro.
The surgical cutting of a bone. (Dorland, 28th ed)
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Proteins prepared by recombinant DNA technology.
Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.
A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
Transection or severing of an axon. This type of denervation is used often in experimental studies on neuronal physiology and neuronal death or survival, toward an understanding of nervous system disease.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS. It regulates BONE MORPHOGENETIC PROTEIN signaling and plays an essential role in EMBRYONIC DEVELOPMENT.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.

Enhancement of osteogenesis in vitro and in vivo by a novel osteoblast differentiation promoting compound, TAK-778. (1/883)

TAK-778 [(2R,4S)-(-)-N-(4-diethoxyphosphorylmethylphenyl)-1,2,4, 5-tetrahydro-4-methyl-7, 8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxyamide; mw 505.53], a novel osteoblast differentiation promoting compound, was characterized in vitro and in vivo models. TAK-778 at doses of 10(-6) M and higher promoted potently bone-like nodule formation in the presence of dexamethasone in rat bone marrow stromal cell culture. This was accompanied by increases in cellular alkaline phosphatase activity, soluble collagen release, and osteocalcin secretion. Under the culture conditions, TAK-778 also stimulated the secretion of transforming growth factor-beta and insulin-like growth factor-I, indicating that TAK-778 may exert regulatory effects on osteoblast differentiation via autocrine/paracrine mechanisms. Furthermore, the in vivo osteogenic potential of TAK-778 was studied in bony defect and osteotomy animal models, using sustained release microcapsules consisted of a biodegradable polymer, poly (dl-lactic/glycolic) acid (PLGA). Single local injection of TAK-778/PLGA-microcapsules (PLGA-MC) (0.2-5 mg/site) to rat skull defects resulted in a dose-dependent increase in new bone area within the defects after 4 weeks. When the pellet containing TAK-778/PLGA-MC (4 mg/pellet) was packed into place to fill the tibial segmental defect in rabbit, this pellet induced osseous union within 2 months, whereas the placebo pellet did not. In addition, single local application of TAK-778/PLGA-MC (10 mg/site) to rabbit tibial osteotomy site enhanced callus formation accompanied by an increase in breaking force after 30 days. These results reveal for the first time that a nonendogenous chemical compound promotes potently osteogenesis in vitro and enhances new bone formation during skeletal regeneration and bone repair in vivo and should be useful for the stimulation of fracture healing.  (+info)

Acceleration of increase in bone mineral content by low-intensity ultrasound energy in leg lengthening. (2/883)

The effect of ultrasound energy on bone has been studied for a long time. In particular, multiple effects of low-intensity ultrasound energy have recently been demonstrated experimentally, such as increases in bending strength of fracture callus, acceleration of soft callus formation and endochondral ossification of the callus at the fracture site, stimulation of aggrecan gene expression, or modulation of TGF-beta synthesis and increase of calcium uptake. Clinically, prospective, randomized, and double-blind trials showed the efficacy of low-intensity ultrasound beam stimulation in the acceleration of fracture healing, with a significant decrease in the time to healing. On the other hand, callotasis, a popular method for bone lengthening, requires much time for new bone formation, and an external fixator must be remain on the patient for a long period. This is one of the major problems of the callotasis technique. If ultrasound energy stimulation could accelerate the rate of callus formation in callotasis, the external fixator could be removed earlier, the treatment period could be shortened, and the patient could return to daily activities more quickly. We report on the use low-intensity ultrasound beam stimulation during leg lengthening with the callotasis method in which callus formation was poor.  (+info)

Bone morphogenetic proteins in human bone regeneration. (3/883)

Recently, the first clinical reports on bone regeneration by two recombinant human bone morphogenetic proteins (rhBMPs), BMP-2 and BMP-7 (also named osteogenic protein-1, OP-1) have been published (1-4). Although both BMPs were able to support bone regeneration, a significant variation in individual response was observed with both proteins. Animal studies and laboratory experiments reveal a number of conditions that influence the osteoinductivity of BMP, such as BMP concentration, carrier properties and influence of local and systemic growth factors and hormones. In this paper, these studies and the clinical reports are reviewed, and the conditions that modulate the BMP-dependent osteoinduction are discussed. The information may provide clues as to how the performance of recombinant human BMP as bone-graft substitute in humans can be improved.  (+info)

Bone marrow stromal cells: characterization and clinical application. (4/883)

The bone marrow stroma consists of a heterogeneous population of cells that provide the structural and physiological support for hematopoietic cells. Additionally, the bone marrow stroma contains cells with a stem-cell-like character that allows them to differentiate into bone, cartilage, adipocytes, and hematopoietic supporting tissues. Several experimental approaches have been used to characterize the development and functional nature of these cells in vivo and their differentiating potential in vitro. In vivo, presumptive osteogenic precursors have been identified by morphologic and immunohistochemical methods. In culture, the stromal cells can be separated from hematopoietic cells by their differential adhesion to tissue culture plastic and their prolonged proliferative potential. In cultures generated from single-cell suspensions of marrow, bone marrow stromal cells grow in colonies, each derived from a single precursor cell termed the colony-forming unit-fibroblast. Culture methods have been developed to expand marrow stromal cells derived from human, mouse, and other species. Under appropriate conditions, these cells are capable of forming new bone after in vivo transplantation. Various methods of cultivation and transplantation conditions have been studied and found to have substantial influence on the transplantation outcome. The finding that bone marrow stromal cells can be manipulated in vitro and subsequently form bone in vivo provides a powerful new model system for studying the basic biology of bone and for generating models for therapeutic strategies aimed at regenerating skeletal elements.  (+info)

Bone wound healing after maxillary molar extraction in ovariectomized aged rats: quantitative backscattered electron image analysis. (5/883)

The processes of bone wound healing after maxillary molar extraction in ovariectomized aged rats were examined by means of quantitative backscattered electron image analysis and energy-dispersive X-ray microanalysis. Six-month-old female rats were either sham-operated or underwent bilateral ovariectomy (OVX), and 60 days postoperatively, the maxillary first molars were extracted. On post-extraction days 7, 30, and 60, the dissected and resin-embedded maxillae were micromilled in the transverse direction through the extracted alveolar sockets, and new bone formation on the buccal maxillary bone surface and within the extracted alveolar sockets was examined. In both sham-operated control and OVX rats, new bone formation was recognized on the buccal bone surface, as well as within the extracted sockets, and increased daily through to day 60. In comparison to sham-operated controls, new bone formation in OVX rats was significantly decreased both on the buccal bone surface and within the extracted sockets. Our results suggest that bone wound healing by new bone formation after maxillary molar extraction is significantly decreased in OVX-induced osteoporosis.  (+info)

Healing of erosions in rheumatoid arthritis. (6/883)

Reports on healing of erosions in rheumatoid arthritis are rare. However, it is expected that repair of erosions should be seen more often during the period of extensive use of disease modifying antirheumatic drugs, especially in patients who experience sustained remission. Two such cases are described.  (+info)

A modular femoral implant for uncemented stem revision in THR. (7/883)

We present the early results of 142 uncemented femoral stem revisions using the modular MRP-Titan system. There were 70 cases with marked preoperative femoral bone defects (Paprosky type 2C and type 3); and bone grafts were used in 31 cases. At a mean follow-up of 2.3 years five cases were re-revised due to dislocation and two due to aseptic loosening. The mean Harris hip score improved from 37.4 preoperatively to 92.4. In 122 cases progressive bone regeneration on X-ray was seen; and no further osteolysis was observed.  (+info)

The Wagner revision prosthesis consistently restores femoral bone structure. (8/883)

The short-term results are reported for 43 hip revision operations with the long-stemmed Wagner prosthesis. The patients were followed-up for an average of 25 months. The Charnley scores were; pain 5.2, movement 4.0 and walking 4.0. All patients except one showed abundant new bone formation. The stem subsided more than 20 mm in 5 patients and in 22 the subsidence was less than 5 mm. The major complication was dislocation, which occurred in 9 patients; 8 of these were reoperated and from then on remained stable.  (+info)

Some common types of bone diseases include:

1. Osteoporosis: A condition characterized by brittle, porous bones that are prone to fracture.
2. Osteoarthritis: A degenerative joint disease that causes pain and stiffness in the joints.
3. Rheumatoid arthritis: An autoimmune disorder that causes inflammation and pain in the joints.
4. Bone cancer: A malignant tumor that develops in the bones.
5. Paget's disease of bone: A condition characterized by abnormal bone growth and deformity.
6. Osteogenesis imperfecta: A genetic disorder that affects the formation of bone and can cause brittle bones and other skeletal deformities.
7. Fibrous dysplasia: A rare condition characterized by abnormal growth and development of bone tissue.
8. Multiple myeloma: A type of cancer that affects the plasma cells in the bone marrow.
9. Bone cysts: Fluid-filled cavities that can form in the bones and cause pain, weakness, and deformity.
10. Bone spurs: Abnormal growths of bone that can form along the edges of joints and cause pain and stiffness.

Bone diseases can be diagnosed through a variety of tests, including X-rays, CT scans, MRI scans, and bone biopsies. Treatment options vary depending on the specific disease and can include medication, surgery, or a combination of both.

There are several factors that can contribute to bone resorption, including:

1. Hormonal changes: Hormones such as parathyroid hormone (PTH) and calcitonin can regulate bone resorption. Imbalances in these hormones can lead to excessive bone resorption.
2. Aging: As we age, our bones undergo remodeling more frequently, leading to increased bone resorption.
3. Nutrient deficiencies: Deficiencies in calcium, vitamin D, and other nutrients can impair bone health and lead to excessive bone resorption.
4. Inflammation: Chronic inflammation can increase bone resorption, leading to bone loss and weakening.
5. Genetics: Some genetic disorders can affect bone metabolism and lead to abnormal bone resorption.
6. Medications: Certain medications, such as glucocorticoids and anticonvulsants, can increase bone resorption.
7. Diseases: Conditions such as osteoporosis, Paget's disease of bone, and bone cancer can lead to abnormal bone resorption.

Bone resorption can be diagnosed through a range of tests, including:

1. Bone mineral density (BMD) testing: This test measures the density of bone in specific areas of the body. Low BMD can indicate bone loss and excessive bone resorption.
2. X-rays and imaging studies: These tests can help identify abnormal bone growth or other signs of bone resorption.
3. Blood tests: Blood tests can measure levels of certain hormones and nutrients that are involved in bone metabolism.
4. Bone biopsy: A bone biopsy can provide a direct view of the bone tissue and help diagnose conditions such as Paget's disease or bone cancer.

Treatment for bone resorption depends on the underlying cause and may include:

1. Medications: Bisphosphonates, hormone therapy, and other medications can help slow or stop bone resorption.
2. Diet and exercise: A healthy diet rich in calcium and vitamin D, along with regular exercise, can help maintain strong bones.
3. Physical therapy: In some cases, physical therapy may be recommended to improve bone strength and mobility.
4. Surgery: In severe cases of bone resorption, surgery may be necessary to repair or replace damaged bone tissue.

Some common types of bone neoplasms include:

* Osteochondromas: These are benign tumors that grow on the surface of a bone.
* Giant cell tumors: These are benign tumors that can occur in any bone of the body.
* Chondromyxoid fibromas: These are rare, benign tumors that develop in the cartilage of a bone.
* Ewing's sarcoma: This is a malignant tumor that usually occurs in the long bones of the arms and legs.
* Multiple myeloma: This is a type of cancer that affects the plasma cells in the bone marrow.

Symptoms of bone neoplasms can include pain, swelling, or deformity of the affected bone, as well as weakness or fatigue. Treatment options depend on the type and location of the tumor, as well as the severity of the symptoms. Treatment may involve surgery, radiation therapy, chemotherapy, or a combination of these.

The alveolar bone is a specialized type of bone that forms the socket in which the tooth roots are embedded. It provides support and stability to the teeth and helps maintain the proper position of the teeth in their sockets. When the alveolar bone is lost, the teeth may become loose or even fall out completely.

Alveolar bone loss can be detected through various diagnostic methods such as dental X-rays, CT scans, or MRI scans. Treatment options for alveolar bone loss depend on the underlying cause and may include antibiotics, bone grafting, or tooth extraction.

In the context of dentistry, alveolar bone loss is a common complication of periodontal disease, which is a chronic inflammatory condition that affects the supporting structures of the teeth, including the gums and bone. The bacteria that cause periodontal disease can lead to the destruction of the alveolar bone, resulting in tooth loss.

In addition to periodontal disease, other factors that can contribute to alveolar bone loss include:

* Trauma or injury to the teeth or jaw
* Poorly fitting dentures or other prosthetic devices
* Infections or abscesses in the mouth
* Certain systemic diseases such as osteoporosis or cancer

Overall, alveolar bone loss is a significant issue in dentistry and can have a major impact on the health and function of the teeth and jaw. It is essential to seek professional dental care if symptoms of alveolar bone loss are present to prevent further damage and restore oral health.

A hematocele is a rare condition where blood accumulates within the membranes that surround the brain and spinal cord (meninges). It can occur at any age but is more common in infants and young children. The accumulation of blood can cause increased pressure on the brain, which can lead to a range of symptoms including headaches, vomiting, seizures, and developmental delays.

Causes and Risk Factors

The exact cause of hematocele is not well understood, but it is thought to be related to abnormal blood vessels in the meninges. Some potential risk factors for developing a hematocele include:

* Genetic mutations
* Infections such as meningitis or encephalitis
* Traumatic brain injury
* Tumors or cysts in the brain


The symptoms of hematocele can vary depending on the location and size of the accumulated blood. Common symptoms include:

* Headaches
* Vomiting
* Seizures
* Developmental delays
* Weakness or paralysis
* Vision problems


Diagnosis of hematocele is typically made through a combination of imaging tests such as MRI and CT scans, and lumbar puncture. These tests can help to confirm the presence of blood in the meninges and rule out other conditions that may be causing similar symptoms.


Treatment for hematocele usually involves surgery to drain the accumulated blood and repair any underlying abnormalities. In some cases, medications such as anticonvulsants and corticosteroids may be prescribed to help manage symptoms.


The prognosis for hematocele is generally good if treated promptly and effectively. However, the condition can have serious complications if left untreated, including brain damage, seizures, and developmental delays.


There is no known way to prevent hematocele, as it is a rare and spontaneous condition. However, early detection and prompt treatment can improve outcomes for affected individuals.

There are several different types of skull fractures, including:

1. Linear skull fractures: These are fractures that occur in a straight line and do not involve the brain.
2. Depressed skull fractures: These are fractures that cause the bone to be pushed inward, creating a depression in the skull.
3. Comminuted skull fractures: These are fractures that involve multiple pieces of bone breaking off and fragmenting.
4. Basilar skull fractures: These are fractures that occur at the base of the skull and can involve the brainstem or cranial nerves.
5. Cerebral edema: This is a condition in which fluid accumulates in the brain as a result of a head injury or other traumatic event.
6. Epidural hematoma: This is a collection of blood between the skull and the dura mater, which is the membrane that covers the brain.
7. Subdural hematoma: This is a collection of blood between the dura mater and the brain.
8. Intracerebral hematoma: This is a collection of blood within the brain tissue.

Skull fractures can be diagnosed using a variety of imaging tests, such as X-rays, CT scans, or MRI scans. Treatment for skull fractures may involve observation, medication, or surgery, depending on the severity of the injury and any other complications that may have arisen.

Complications of skull fractures can include:

1. Cerebral edema
2. Epidural hematoma
3. Subdural hematoma
4. Intracerebral hematoma
5. Brain contusion
6. Skull base fractures
7. Facial trauma
8. Sinus fractures
9. Orbital blowout fractures
10. Meningitis or sepsis.

It is important to seek medical attention immediately if any of the following symptoms are present:

1. Severe headache
2. Confusion or disorientation
3. Slurred speech or difficulty speaking
4. Weakness or numbness in the arms or legs
5. Vision changes, such as double vision or blurred vision
6. Difficulty with balance or coordination
7. Seizures or convulsions
8. Fever
9. Stiff neck
10. Loss of consciousness or coma.

Mandibular Injuries can range from mild to severe and can affect different parts of the jaw bone, including the symphysis (the joint between the two halves of the mandible), the condyle (the rounded end of the mandible that articulates with the temporal bone of the skull), and the ramus (the outer portion of the mandible).

Some common types of Mandibular Injuries include:

1. Fractures: These are breaks in the bone that can be caused by direct trauma or a sudden impact.
2. Luxation injuries: These occur when the jaw bone becomes dislocated or moves out of its normal position.
3. Avulsions: These occur when a piece of bone is torn away from the rest of the mandible.
4. Subluxations: These occur when the jaw bone partially dislocates or slips out of place.
5. Contusions: These are bruises that occur when the mandible hits another object or surface.
6. Stretching and tearing of the soft tissue surrounding the mandible, such as muscles, ligaments, and tendons.

Symptoms of Mandibular Injuries can include pain, swelling, difficulty opening or closing the mouth, difficulty speaking or eating, and difficulty moving the jaw. Treatment for these injuries may involve immobilization of the mandible with a splint or cast, medication to manage pain and inflammation, and in some cases surgery to realign or repair the bone.

Mandibular fractures can be classified into different types based on their location and severity. Some common types of mandibular fractures include:

1. Symphyseal fracture: This type of fracture occurs in the joint portion of the mandible, where the two bone parts meet.
2. Body fracture: This type of fracture occurs in the main body of the mandible.
3. Condylar fracture: This type of fracture occurs in the part of the mandible that forms the jaw joint, called the condyle.
4. Angle fracture: This type of fracture occurs near the angle of the mandible, where it meets the maxilla (the bone of the upper jaw).
5. Subcondylar fracture: This type of fracture occurs below the condyle, in the lower part of the mandible.

The symptoms of mandibular fractures can vary depending on the severity of the injury, but may include:

* Pain and tenderness in the jaw and facial area
* Swelling and bruising around the affected eye
* Difficulty opening or closing the mouth
* Numbness or tingling in the lower jaw and tongue
* Difficulty speaking or eating

Treatment for mandibular fractures usually involves immobilizing the jaw with a splint or brace to allow the bone to heal properly. In some cases, surgery may be required to realign the bones and secure them in place with plates, screws, or wires.

Complications of mandibular fractures can include:

* Infection
* Nerve damage
* Facial asymmetry
* Difficulty speaking or eating
* Temporomandibular joint (TMJ) dysfunction

It is important to seek medical attention immediately if you suspect that you have a mandibular fracture, as prompt treatment can help prevent complications and improve outcomes.

Open fracture: The bone breaks through the skin, exposing the bone to the outside environment.

Closed fracture: The bone breaks, but does not penetrate the skin.

Comminuted fracture: The bone is broken into many pieces.

Hairline fracture: A thin crack in the bone that does not fully break it.

Non-displaced fracture: The bone is broken, but remains in its normal position.

Displaced fracture: The bone is broken and out of its normal position.

Stress fracture: A small crack in the bone caused by repetitive stress or overuse.

Some common types of mandibular neoplasms include:

1. Ameloblastoma: A rare benign tumor that arises from the odontogenic epithel, which is the tissue responsible for the formation of teeth.
2. Odontogenic keratocyst: A benign tumor that originates in the mandible and can expand to involve the surrounding bone and soft tissues.
3. Myxoid chondromatosis: A rare benign tumor that consists of multiple cartilaginous nodules that are surrounded by a loose connective tissue stroma.
4. Chondroderivative osteoma: A rare benign bone tumor that arises from the mutation of cartilage cells during bone development.
5. Ossifying fibroma: A benign tumor that is made up of immature bone tissue and typically affects the jawbone.
6. Fibrosarcoma: A malignant tumor that arises from the connective tissue of the mandible, such as the periodontal ligament or the muscles of mastication.
7. Osteosarcoma: A malignant bone tumor that can arise in any bone of the body, including the mandible.

Symptoms of mandibular neoplasms can include pain, swelling, and difficulty opening the mouth or biting. Treatment options depend on the type and stage of the neoplasm and may involve surgery, radiation therapy, or a combination of both. Early detection and treatment are important to improve outcomes and minimize the risk of complications.

The symptoms of a femoral fracture may include:

* Severe pain in the thigh or groin area
* Swelling and bruising around the affected area
* Difficulty moving or straightening the leg
* A visible deformity or bone protrusion

Femoral fractures are typically diagnosed through X-rays, CT scans, or MRIs. Treatment for these types of fractures may involve immobilization with a cast or brace, surgery to realign and stabilize the bone, or in some cases, surgical plate and screws or rods may be used to hold the bone in place as it heals.

In addition to surgical intervention, patients may also require physical therapy to regain strength and mobility in the affected leg after a femoral fracture.

* Osteogenesis imperfecta (OI): A genetic disorder that affects the formation of bone tissue, leading to fragile bones and an increased risk of fractures.
* Rickets: A vitamin D-deficient disease that causes softening of the bones in children.
* Osteomalacia: A condition similar to rickets, but affecting adults and caused by a deficiency of vitamin D or calcium.
* Hyperparathyroidism: A condition in which the parathyroid glands produce too much parathyroid hormone (PTH), leading to an imbalance in bone metabolism and an increase in bone resorption.
* Hypoparathyroidism: A condition in which the parathyroid glands produce too little PTH, leading to low levels of calcium and vitamin D and an increased risk of osteoporosis.

Bone diseases, metabolic are typically diagnosed through a combination of physical examination, imaging studies such as X-rays or CT scans, and laboratory tests to evaluate bone metabolism. Treatment depends on the specific underlying cause of the disease and may include medications, dietary changes, or surgery.

The exact cause of ameloblastoma is not known, but it is believed to be related to genetic mutations that affect the development and growth of the odontogenic epithel. The tumor typically affects individuals between 20 and 40 years of age, with a slight male predilection.

There are several types of ameloblastoma, including:

1. Solitary (unilateral) ameloblastoma: This is the most common type, accounting for approximately 75% of all cases. It is a single tumor that arises in one location in the jawbone.
2. Multicentric ameloblastoma: This type accounts for approximately 20% of all cases and involves multiple tumors that arise in different locations in the jawbone.
3. Mixed (bilateral) ameloblastoma: This is a rare type that affects both sides of the jawbone.

Ameloblastoma is diagnosed based on a combination of clinical, radiographic, and histopathological findings. Treatment options include surgery, radiation therapy, and observation. The choice of treatment depends on the size, location, and aggressiveness of the tumor, as well as the patient's overall health.

Prognosis for ameloblastoma is generally good, with a high cure rate when treated appropriately. However, local recurrence can occur in some cases, and there is a small risk of malignant transformation. Follow-up care is essential to monitor for any signs of recurrence or complications.

In summary, ameloblastoma is a rare benign tumor that affects the jawbone and originates from the odontogenic epithel. It can cause symptoms such as pain, swelling, and difficulty opening the mouth. Treatment options include surgery, radiation therapy, and observation, and follow-up care is essential to monitor for any signs of recurrence or complications.

1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.

2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.

3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.

4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.

5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.

6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.

7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.

8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.

9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.

10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.

There are several types of bone cysts, including:

1. Simple bone cysts: These are the most common type of bone cyst and typically occur in children and young adults. They are filled with air or fluid and do not contain any cancerous cells.
2. Angiomatous cysts: These are smaller than simple bone cysts and are usually found near the ends of long bones. They are also filled with blood vessels and do not contain any cancerous cells.
3. Unicameral (simple) bone cysts: These are similar to simple bone cysts but are larger and may be more complex in shape.
4. Multicameral bone cysts: These are larger than unicameral bone cysts and may contain multiple chambers filled with air or fluid.
5. Enchondromas: These are benign tumors that occur within the cartilage of a bone. They are usually found in the long bones of the arms and legs.
6. Chondromyxoid fibromas: These are rare, benign tumors that occur in the cartilage of a bone. They are typically found in the long bones of the arms and legs.
7. Osteochondromas: These are benign tumors that arise from the cartilage and bone of a joint. They are usually found near the ends of long bones.
8. Malignant bone cysts: These are rare and can be cancerous. They may occur in any bone of the body and can be aggressive, spreading quickly to other areas of the body.

The symptoms of bone cysts can vary depending on their size and location. They may cause pain, swelling, and limited mobility in the affected limb. In some cases, they may also lead to fractures or deformities.

Diagnosis of bone cysts usually involves imaging tests such as X-rays, CT scans, or MRI scans. A biopsy may also be performed to confirm the diagnosis and rule out other possible conditions.

Treatment for bone cysts depends on their size, location, and severity. Small, asymptomatic cysts may not require any treatment, while larger cysts may need to be drained or surgically removed. In some cases, medication such as bisphosphonates may be used to help reduce the risk of fractures.

In conclusion, bone cysts are abnormalities that can occur in any bone of the body. They can be benign or malignant and can cause a range of symptoms depending on their size and location. Diagnosis is usually made through imaging tests, and treatment may involve observation, draining, or surgical removal.

There are several types of osteoporosis, including:

1. Postmenopausal osteoporosis: This type of osteoporosis is caused by hormonal changes that occur during menopause. It is the most common form of osteoporosis and affects women more than men.
2. Senile osteoporosis: This type of osteoporosis is caused by aging and is the most common form of osteoporosis in older adults.
3. Juvenile osteoporosis: This type of osteoporosis affects children and young adults and can be caused by a variety of genetic disorders or other medical conditions.
4. secondary osteoporosis: This type of osteoporosis is caused by other medical conditions, such as rheumatoid arthritis, Crohn's disease, or ulcerative colitis.

The symptoms of osteoporosis can be subtle and may not appear until a fracture has occurred. They can include:

1. Back pain or loss of height
2. A stooped posture
3. Fractures, especially in the spine, hips, or wrists
4. Loss of bone density, as determined by a bone density test

The diagnosis of osteoporosis is typically made through a combination of physical examination, medical history, and imaging tests, such as X-rays or bone density tests. Treatment for osteoporosis can include medications, such as bisphosphonates, hormone therapy, or rANK ligand inhibitors, as well as lifestyle changes, such as regular exercise and a balanced diet.

Preventing osteoporosis is important, as it can help to reduce the risk of fractures and other complications. To prevent osteoporosis, individuals can:

1. Get enough calcium and vitamin D throughout their lives
2. Exercise regularly, especially weight-bearing activities such as walking or running
3. Avoid smoking and excessive alcohol consumption
4. Maintain a healthy body weight
5. Consider taking medications to prevent osteoporosis, such as bisphosphonates, if recommended by a healthcare provider.

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The primary objective of the study was to better understand bone healing and bone tissue regeneration and to study the impacts ... "Tissue Regeneration-Bone Defect". "Rodent Research 4 (RR4) (ARC00XX199)". "GUIDE FOR THE CARE AND USE OF LABORATORY ANIMALS ... The primary objective of the study is to examine the CDKN1a/p21 pathway and its role in the arresting bone regeneration in ... The study also intended to gauge certain agents capable of inducing bone healing and regeneration in spaceflight. The study ...
Bone Regeneration and Repair. Totowa, New Jersey: Humana Press. 2005. pp. 225-239. ISBN 978-0-89603-847-9. Holmes, C. F., et al ... After the spine is decompressed, bone graft or artificial bone substitute is packed between the vertebrae to help them heal ... or artificial bone substitutes-to help the bones heal together. Additional hardware (screws, plates, or cages) is often used to ... Interbody Fusion is a graft where the entire intervertebral disc between vertebrae is removed and a bone graft is placed in the ...
"Tissue Regeneration-Bone Defect". Retrieved 11 September 2021.{{cite web}}: CS1 maint: url-status (link) Kearns- ... Fischer and Whitson studied a new drugs effects on mouse bone atrophy, current therapies cannot restore lost bone, but the new ... Garcia, Mark (2 August 2017). "Astronauts Look at Ways to Prevent Space Headaches and Bone Loss". Vein, A. " ... drug from the University of California at Los Angeles had the potential to rebuild bone and block further bone loss. On August ...
"Bone regeneration and stem cells." 2011 Arvidson, K. et al. Journal of Cellular and Molecular Medicine 15, No 4, pp. 718-746. " ... Vaginal Tissue Regeneration Device and Method for Regeneration of Vaginal Lining using Vibration Therapy". May 2012 Barnard, E ... Genital regeneration encompasses various forms of treatment for genital anomalies. The goal of these treatments is to restore ... As is the case in most scientific pursuits, these accomplishments might be applied to other forms of regeneration and vice ...
Cassidy JW (November 2014). "Nanotechnology in the Regeneration of Complex Tissues" (PDF). Bone and Tissue Regeneration ... "Bone in a bottle: Attempts to create artificial bone marrow have failed until now". The Economist. 7 January 2009. Amini AR, ... Artificial bone marrow: Bone marrow cultured in vitro to be transplanted serves as a "just cells" approach to tissue ... their potential and pitfalls for bone tissue regeneration and engineering". Nanomedicine. 9 (8): 1139-1158. doi:10.1016/j.nano. ...
"Creating Artificial Bones for Faster Bone Regeneration". Tokyo Institute of Technology. Retrieved 2018-04-20. Venkatesan, ... Artificial bone refers to bone-like material created in a laboratory that can be used in bone grafts, to replace human bone ... Human bones have the ability to regenerate themselves by cycle of bone resorption and bone formation. The cell responsible for ... or ceramic-collagen composites for bone regeneration. The material used in an artificial bone implant ultimately depends on the ...
September 2014 Cassidy, John W. (2014). "Nanotechnology in the Regeneration of Complex Tissues". Bone and Tissue Regeneration ... For example, when creating scaffolds to support the growth of bone, researchers may mimic osteoclast resorption pits. ...
Membranes used in guided bone regeneration (GBR) and grafting may be of two principal varieties: non-resorbable resorbable. ... Hence, if a bone defect needs to heal, the membrane separates it from the soft tissue, giving time for the bone cells to fill ... Simion M, Scarano A, Gionso L, Piattelli A (1996). "Guided bone regeneration using resorbable and nonresorbable membranes: a ... Wang HL, Boyapati L (March 2006). ""PASS" principles for predictable bone regeneration". Implant Dent. 15 (1): 8-17. doi: ...
The company focusses on bone regeneration. Traditionally, when repairing a severe bone break involving a void, new bone is ... bone morphogenetic protein-7) to initiate rapid bone formation". J Bone Miner Res. 12 (10): 1584-95. doi:10.1359/jbmr.1997.12. ... At the 2017 Healthcare Innovation Summit Africa he presented on bone regeneration technologies. In 2014 Duneas and Nuno Pires ... "Dr Nic Duneas Discusses Bone Regeneration Technologies From Africa - YouTube". IT News Africa. 19 September 2017. ...
Bone regeneration takes place during fracture healing and bone remodeling that takes place throughout life. Bone healing also ... are important in inducing the differentiation of MSCs during bone regeneration. Bone regeneration in adults appears to mimic ... has been shown to negatively affect bone regeneration. The exact reasoning behind the limit on inflammation needed for bone ... mechanobiology also influences bone regeneration. Simply put, compression can enhance bone apposition. This is known as Wolff's ...
... and had a marketed drug in the form of the bone regeneration treatment Osteocel. The company divested Osteocel to NuVasive in ... A peer company, StemCells, emerged in 1995 in California with a focus on neural regeneration, but using stem cell technology ... E6: "Fells Point's Osiris bucks trend with IPO today" Guidera, Mark (11 April 1999). "Maryland companies near regeneration of ... Part 2 of article: "Maryland companies increase role in cell regeneration" Bishop, Tricia (27 March 2007). "Osiris stock gets a ...
The first part of the book discusses regeneration, primarily in salamanders and frogs. Becker studied regeneration after ... He also found that bone has piezoelectric properties which would cause an application of force to generate a healing current, ... In a frog, the voltage would simply change to the normal negative level in four weeks or so, and no limb regeneration would ... Regeneration of the ventricular myocardium in amphibians. Becker RO, Chapin S, Sherry R. Nature. 1974 Mar 8;248(444):145-7. ...
Rothrauff BB, Tuan RS (January 2014). "Cellular therapy in bone-tendon interface regeneration". Organogenesis. 10 (1): 13-28. ... Benjamin M, Toumi H, Ralphs JR, Bydder G, Best TM, Milz S (April 2006). "Where tendons and ligaments meet bone: attachment ... The enthesis (plural entheses) is the connective tissue between tendon or ligament and bone. There are two types of entheses: ... In a fibrous enthesis, the collagenous tendon or ligament directly attaches to the bone. In a fibrocartilaginous enthesis, the ...
"MSC-derived Exosomes Promote Bone Fracture Repair". Stem Cells Portal. 2 January 2017. Silva AM, Teixeira JH, Almeida MI, ... Basu J, Ludlow JW (2016). "Exosomes for repair, regeneration and rejuvenation". Expert Opinion on Biological Therapy. 16 (4): ... bone fracture repair and participates in the regulation of immune-mediated responses and inflammatory diseases. They induce the ... Immunomodulatory messengers in the context of tissue repair/regeneration". European Journal of Pharmaceutical Sciences. 98: 86- ...
Osteoporotic bone marrow defect • Our Lady of Fatima University • Outer enamel epithelium • Painless Parker • Pakistan Medical ... Tooth regeneration • Tooth squeeze • Tooth Tunes • Toothache • Toothbrush • Toothpaste • Toothpick • Torus mandibularis • Torus ... palatinus • Traumatic bone cyst • Traumatic neuroma • Treatment of knocked-out (avulsed) teeth • Trench mouth • Treponema ...
James Bone (April 12, 2016). The Curse of Beauty: The Scandalous & Tragic Life of Audrey Munson, America's First Supermodel. ... Owen Johnson (1916). The Woman Gives: A Story of Regeneration. Library of Alexandria. ISBN 978-1-4656-0301-2. "Beorge Bellows, ... " "known," "wife" The Woman Gives: A Story of Regeneration by Owen Johnson (Boston, Little, Brown, and Company, 1916). Thomas ...
Patt, H. M.; Maloney, M. A. (1975). "Bone marrow regeneration after local injury: A review". Experimental Hematology. 3 (2): ... "Bone Formation and Resorption as a Requirement for Marrow Development". Experimental Biology and Medicine. 140 (1): 205-207. ... "Hematopoietic microenvironment transfer by stromal fibroblasts derived from bone marrow varying in cellularity". Experimental ...
Geiger M, Li RH, Friess W (November 2003). "Collagen sponges for bone regeneration with rhBMP-2". Adv. Drug Deliv. Rev. 55 (12 ... Allegrini S, Yoshimoto M, Salles MB, König B (February 2004). "Bone regeneration in rabbit sinus lifting associated with bovine ... Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. BMP-2 like other bone morphogenetic ... Bone morphogenetic protein 2 has been shown to interact with BMPR1A. Bone morphogenetic protein 2 is shown to stimulate the ...
Geiger, M (2003). "Collagen sponges for bone regeneration with rhBMP-2". Advanced Drug Delivery Reviews. 55 (12): 1613-29. doi: ... bone (main component of the organic part of bone) Type II: cartilage (main collagenous component of cartilage) Type III: ... In bone, entire collagen triple helices lie in a parallel, staggered array. 40 nm gaps between the ends of the tropocollagen ... Collagen is used in bone grafting as it has a triple helical structure, making it a very strong molecule. It is ideal for use ...
Quality of bone healing: Perspectives and assessment techniques. Wound Repair and Regeneration. 22(S1). Johnson Benjamin, ... Localized Low Dose rhBMP-2 Is Effective at Promoting Bone Regeneration in a Pre-Clinical Mandibular Segmental Defect Model. ... Biomask for skin regeneration. Regenerative Medicine. 9(3): 245-8. Guda Teja, Labella Carl, Chan Rodney, et al. 2014. ... Wound Repair and Regeneration. 21(2):A40-A40. Hale, Robert G. 2013. Challenges in Craniofacial Reconstruction Following Trauma ...
He developed techniques for the removal of fragments of bone, so as to allow regeneration, and the use of silver nitrate to ... He examined the writings of surgeon Michele Troja, who noted the regeneration of bone tissue at site. In 1852, Larghi was able ... Lazzeri, Davide; Gatti, Gian Luca; Romeo, Gianfranco; Balmelli, Bruno; Massei, Alessandro (2009). "Bone Regeneration and ... He also designed surgical instruments for sectioning bones in-situ. Larghi was born in Vercelli to Francesco and Maria Giudice ...
January 2003). "Autologous bone-marrow stem-cell transplantation for myocardial regeneration". Lancet. 361 (9351): 45-46. doi: ... When comparing the rates of MSC in the bone marrow aspirates and bone marrow stroma, the aspirates tend to have lower rates of ... Bone marrow transplant is a form of stem cell therapy that has been used for many years because it has proven to be effective ... The quantity of bone marrow stem cells declines with age and is greater in males than females during reproductive years. Much ...
BMPs promotes the regeneration of bone tissue and cartilage. BMP exhibits osteoinductive activity. Osteoinductive activity ... A bone growth factor is a growth factor that stimulates the growth of bone tissue. Known bone growth factors include insulin- ... and acts as a central component in the coupling of bone formation and its resorption during bone remodeling. Bone Morphogenic ... Al-Bluwi MT, Azam MQ, Sadat-Ali M (2016). "The effect of bone growth factor in the tendon to bone healing in anterior cruciate ...
The material is used to stimulate natural bone regeneration. A clinical study of this technique detailed all patients within ... It is inserted during a sinus lift or augmentation and used to increase the amount of bone to support dental implants. Implants ... It also showed vertical bone gain in all subjects. Numerous different types of material have been used as sinus implants during ... Implants can be in conjunction with sinus surgery to treat chronic sinusitis and also in sinus augmentation to increase bone ...
"Bone, Muscle, and Nerve Regeneration and Bone Transplantation Experiments". Doctors From Hell: The Horrific Account Of Nazi ... For example, 74 young Polish women were subjected to medical experiments on bone and muscle transplantation, nerve regeneration ...
PRF is used in guided bone and tissue regeneration. PRF enhances alveolar bone augmentation and necrotic dental pulp and open ... Demineralized freeze dried bone allograft (DFDBA) has been histologically proven to be the material of choice for regeneration ... in the alveolar bone. A platelet-rich fibrin (PRF) membrane containing bone growth enhancing elements can be stitched over the ... "Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation". BioMed Research International ...
A major new regeneration project on the site of the former port area and the 40-acre (160,000 m2) former Ministry of Defence ... Bones from the cist were radiocarbon dated and found to be over four millennia old, originating within the date range 2152 to ... Nicknamed Torbrex Tam, the man, whose bones were discovered by workmen, died while still in his twenties. Other Bronze Age ...
The founder of the college is Christopher Ogunsalu, the inventor of the Ogunsalu Sandwich bone regeneration technique. List of ... the resorbable guided tissue regeneration membrane--bone substitute sandwich technique". The West Indian Medical Journal. 54 (4 ...
Robotic Assistant Robot for Bone-Fracture Reposition Surgery, which replaces assistant surgeons who align the broken bone to ... Mesenchymal stem cell delivery scaffold with magnetic actuating system for articular cartilage regeneration. With size of 200~ ... An articulated robotic arm to carry a human & respiration synchronization method) Surgeon-Robot Interaction for Bone-Fracture ...
1996) Established the Laminar Air Flow Room and the Bone Marrow Transplantation Center. (1995) The hospital is in walking ... neural regeneration and repair, and epilepsy research and patient care of the nation. Established National PET/Cyclotron Center ...
Previously, beaded art was made with bone, seeds, jade, ceramics, or other like materials when now the Huichols have access to ... the shaman is alleged by the Huichols to be able to speak to the gods and ensure the regeneration of the Huichols' souls. ...
... - has been related to hair follicles' melanocyte regeneration and CD34+ with neuronal regeneration. Cluster of ... Cells expressing CD34 (CD34+ cell) are normally found in the umbilical cord and bone marrow as haematopoietic cells, or in ... It may also mediate the attachment of hematopoietic stem cells to bone marrow extracellular matrix or directly to stromal cells ... Clinically, it is associated with the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Due to ...
The vertebral bones or intervertebral disks can shatter, causing the spinal cord to be punctured by a sharp fragment of bone. ... promoting cell regeneration, and replacing lost cells. Regeneration is facilitated by maintaining electric transmission in ... Between the dura mater and the surrounding bone of the vertebrae is a space called the epidural space. The epidural space is ... Meanwhile, the overlying ectoderm secretes bone morphogenetic protein (BMP). This induces the roof plate to begin to secrete ...
In the skeletal muscles connected to tendons that pull on bones, the mysia fuses to the periosteum that coats the bone. ... Mammals have the ability to complete small amounts of cardiac regeneration during development. Other vertebrates can regenerate ... Contraction of the muscle will transfer to the mysia, then the tendon and the periosteum before causing the bone to move. The ... There are three phases to the regeneration process. These phases include the inflammatory response, the activation, ...
Ken Bones as the General of Gallifrey. Jonjo O'Neill as McGilliop. Aidan Cook and Paul Kasey as the Zygons. Nicholas Briggs as ... "The Night of the Doctor" depicts the Eighth Doctor's regeneration into the War Doctor. After being resurrected temporarily by ... s regeneration into the War Doctor (John Hurt). Another 4-minute special, entitled "The Last Day", was released on 20 November ... offering him a selection of potions to control his regeneration. "The Last Day" is filmed from the first-person perspective of ...
2. The increased distance between inter-proximal contact position to bone crest, example to that is the naturally occurring ... Clark, D (2008). "Restoratively driven papilla regeneration: Correcting the dreaded 'black triangle'". Texas Dental Journal. ...
The historic county of Monmouthshire, lying in the Welsh Marches (the Anglo-Welsh border), is a bone of contention for some ... Regional Assemblies were abolished in 2010 as part of a Sub-National Review of Economic Development and Regeneration with most ...
... they jump the perimeter wall and explore the 309th Aerospace Maintenance and Regeneration Group Aircraft Bone Yard on Davis- ...
Molecular Regenerative Medicine Molecular Sports and Rehabilitation Medicine Neurointervention Tendon and Bone Regeneration ... Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS) Public Health and Healthcare Research The main research ...
Doschak, M. R.; Zernicke, R. F. (March 2005). "Structure, function and adaptation of bone-tendon and bone-ligament complexes". ... and Myofiber Regeneration in Skeletal Muscle Following Contusion Injury". Frontiers in Physiology. 8: 93. doi:10.3389/fphys. ... Ligaments are tough, inelastic fibers made of collagen that connect two or more bones to form a joint and are important for ... However, x-rays can be obtained to help identify fractures, especially in cases of tenderness or bone pain at the injured site ...
Rincon JC, Young WG, Bartold PM (2006). "The epithelial cell rests of Malassez--a role in periodontal regeneration?". Journal ... epithelial-mesenchymal transition and differentiate into diverse types of cells of mesodermal and ectodermal origin like bone, ... Some rests become calcified in the periodontal ligament (cementicles). ERM plays a role in cementum repair and regeneration. ... maintenance and regeneration of periodontal ligament tissues". Periodontol 2000. 63 (1): 217-33. doi:10.1111/prd.12023. PMID ...
English writer Stephen Gallagher uses the Wandering Jew as a theme in his 2007 novel The Kingdom of Bones. The Wandering Jew is ... Fig.3.3, p.79 in Todd Presner Muscular Judaism: The Jewish Body and the Politics of Regeneration. Routledge, 2007. The ...
"Accelerated and longterm hematopoietic engraftment in mice transplanted with ex-vivo expanded bone marrow". Bone Marrow ... It also has many more specific effects like the regeneration of platelets and potentially aids in early antibody isotype ... However, only IL-3 treatment in bone marrow failure disorders such as myelodysplastic syndrome (MDS) and aplastic anemia (AA) ... Post-chemotherapy, IL-3 application reduces chemotherapy delays and promotes regeneration of granulocytes and platelets. ...
Bone, Q. (2008). Biology of fishes. Richard H. Moore (3rd ed.). New York: Taylor & Francis. ISBN 978-0-203-88522-2. OCLC ... Shimomura, O.; Johnson, F.H. (1975). "Regeneration of the photoprotein aequorin". Nature. 256 (5514): 236-238. Bibcode: ...
The present local administration, however, has become more tourism-orientated, and it has promoted the regeneration of the ... "Spit Out the Bone" (2016) by Metallica. The Feast of the Madonna della Bruna, held in Matera on 2 July each year, is notable ...
New York Daily News, "Bone snatcher Michael Mastromarino dies of bone cancer as victims see sad irony", July 7, 2013 Law & ... BTS sold its products to five companies; two of the companies were Life Cell Corporation, of New Jersey, and Regeneration ... "Alistair Cooke's bones 'stolen'", December 22, 2005 The New York Times "Alistair Cooke's Bones Were Stolen for Implantation, ... Similar storyline in Bones: "The Graft in the Girl" (Season 1, Episode 20), airing April 26, 2006. In documentary TV series ...
"Blood and Thunder: Regeneration". Retrieved 14 May 2008. "Lady Antebellum 'Own' the Billboard 200 with Second ... Danzig and Mother Love Bone" sound the same. Thrash metal emerged in the early 1980s under the influence of hardcore punk and ...
The second set of experiments studied bone, muscle, and nerve regeneration, and the possibility of transplanting bones from one ... In bone operations, each cut is reopened. Bones are operated on both legs or just one." and "We are worried that they will want ... These experiments involved deliberate cutting into and infecting of leg bones and muscles with virulent bacteria, cutting ... From this, 56 from the Lublin September transport, of which 36 were infection operations (without incision), 20 bone operations ...
As part of the regeneration of Castlemilk in 1999, several public artworks were commissioned and placed at prominent entrances ... bone, bottle glass and a clay pipe bowl that would date the deposit to the 18th century if not earlier. The remains of a stone ... "Case study: Castlemilk Stables, Glasgow". The Prince's Regeneration Trust. Archived from the original on 26 October 2017. ... the area has seen the benefits of a regeneration strategy implemented in the 1980s which has focused on improved housing and ...
"Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix". Biomaterials. 31 (23): 6004-12. doi:10.1016/j. ... with potential applications in bone and cartilage regeneration, angiogenesis for ischemia or peripheral artery disease, cancer ... "Supramolecular design of self-assembling nanofibers for cartilage regeneration". PNAS. 107 (8): 3293-8. doi:10.1073/pnas. ...
But a Pernida clone manages to kill Nemu and eats her body, only to end up dying from excess regeneration due to the ... This offshoot assumes the form of a silent, young kunoichi that sees battle as a game, named Kyōkotsu (狂骨, Madness Bone) and ... Katen Kyōkotsu (花天狂骨, Bones of Heavenly Blooming Madness) is a pair of Zanpakutō owned by Shunsui Kyōraku. Shunsui's Zanpakutō ...
... has been shown to be involved in skin physiology, specifically in tissue regeneration. The process of ... Yamashita J, McCauley LK (2006). "The Activating Protein-1 Transcriptional Complex: Essential and Multifaceted Roles in Bone". ... Clinical Reviews in Bone and Mineral Metabolism. 4 (2): 107-122. doi:10.1385/BMM:4:2:107. S2CID 90318354. Zumerle S, Alimonti A ... life span and tissue regeneration. Below are some of the other important functions and biological roles AP-1 transcription ...
Xu W, Cox CS, Li Y (2011). "Induced pluripotent stem cells for peripheral nerve regeneration". Journal of Stem Cells. 6 (1): 39 ... bone degeneration, and changes in the skin, hair, and nails. Additionally, motor neuropathy may cause impaired balance and ...
In the same report he first described the use of a membrane for periodontal regeneration. Younger practiced for some time in ... process in which gingival graft tissue could be removed from one site in the mouth and properly reattached to the alveolar bone ...
Another Florentine of this period was Niccolò Machiavelli, whose prescriptions for Florence's regeneration under strong ... T-bone steak of Chianina beef cooked over hot charcoal and served very rare with its more recently derived version, the ...
Professor James Drummond Bone, FRSE, Vice-Chancellor, University of Liverpool. For services to Higher Education and to ... For services to Higher Education, Medical Science and to Regeneration in the North East. Mark Philip Elder, CBE, Conductor and ... For services to the Regeneration of Leicester. Erinma Bell, Chair, Community Alliance for Renewal, Inner South Manchester Area ... For services to Urban Regeneration. Elizabeth Robson, Managing Director, Robson Builders (Hexham) Ltd. For services to the ...
... discuss the science behind True Periodontal Regeneration with the PerioLase MVP-7 and the LANAP & LAPIP protocols. ... Come hear one of the leading voices in periodontal regeneration and peri-implantitis, Sunil Thanik, DMD, MSD, ... "Lasers for Periodontal Bone Regeneration" Dinner Presentation. Come hear one of the leading voices in periodontal regeneration ... "Lasers for Periodontal Bone Regeneration" Dinner Presentation 1601 Van Ness Ave, San Francisco, CA, 94019, US ...
In conclusion, we confirmed neo-bone formation within a cranial bone defect using hDPSCs and a computer-designed PLGC scaffold. ... to regenerate neo-bone within cranial bone defects. The hDPSCs expressed mesenchymal stem cell markers and served as an ... and histology of the in vivo tissue-engineered bone. Neo-bone formation of more than 50% in both micro-CT and histology tests ... To assess bone tissue engineering in vivo, the computer-designed, circular PLGC scaffold was implanted into a full-thickness ...
Researchers have engineered a regenerative implant that could help repair bone-deep damage following physical trauma, surgery ... It can begin promoting bone regeneration within a very short timeframe.". The regenerated bone featured more minerals, such as ... When implanted in rats with bone defects, the cylindrical scaffold promoted the regeneration of bone that was denser, more ... "We found that the radially aligned nanofibers can really enhance the bone regeneration in this scenario, especially with the ...
Autologous transplantation with bone marrow-mesenchymal stem cells (BMSCs)... ... Bone marrow derived stem cells facilitate axonal regeneration in a rat model of 2, 5-hexanedione-induced neuropathy via miRNA- ... Evaluation of autologous bone marrow-derived mesenchymal stem cells on renal regeneration after experimentally induced acute ... Bone marrow stem cells in facial nerve regeneration from isolated stumps. Muscle Nerve. 2013;48:423-9. ...
... * QMRO Home ... The effect of experimental osteoporosis on bone regeneration: Part 1, histology findings. ... The effect of experimental osteoporosis on bone regeneration: Part 1, histology findings ... The effect of experimental osteoporosis on bone regeneration: Part 1, histology findings. Clin. Oral Impl. Res. 00, 2016, 1-10 ...
Cleft and Craniofacial Surgery Cartilage Regeneration Bone Regeneration Compromised Wound Healing Corrective Jaw Surgery ...
MAZARO, José Vitor Quinelli et al. The guided bone regeneration in implant dentistry - case report. RFO UPF []. 2014, 19, 1, pp ... Final considerations: The guided bone regeneration technique employed showed satisfactory performance. The patient was positive ... and materials used in guided bone regeneration applied to Implantology. Case report: A clinical case of a patient who received ... Objective: The use of methods for tissue regeneration has been widely applied in Implantology, in clinical situations with ...
... she began working with a group of proteins known as bone morphogenic proteins to achieve bone and cartilage regeneration. Bone ... Bone and Cartilage Regeneration Medicine. This challenge has long fascinated Professor Keolebogile Shirley Motaung, Director of ... Repairing bone and cartilage in joints after an injury has been a long-standing challenge in the field of regenerative medicine ... Both plants contain chemicals that can activate body cells, enhance bone formation and heal wounds in vitro. When combined with ...
keywords = "bone regeneration, guided bone regeneration, inflammation, salicylic acid-based poly(anhydride-ester) polymer, ... Dive into the research topics of Development of a guided bone regeneration device using salicylic acid-poly(anhydride-ester) ... T1 - Development of a guided bone regeneration device using salicylic acid-poly(anhydride-ester) polymers and osteoconductive ... Development of a guided bone regeneration device using salicylic acid-poly(anhydride-ester) polymers and osteoconductive ...
Implants sites with concomitant bone regeneration using a resorbable or non-resorbable membrane result in stable marginal bone ... The median marginal bone levels were located 0.23 mm (0.06; 0.46; RES) and 0.17 mm (0.13;0.28; N-RES) below the implant ... GBR was randomly performed using a resorbable (RES) or a non-resorbable membrane (N-RES) combined with a bone substitute ... alterations of peri-implant hard and soft tissues around single implants treated with simultaneous guided bone regeneration ( ...
Researchers develop novel bio-inspired molecules to enhance bone regeneration Peoples ability to regenerate bones declines ...
A technology for guiding bone regeneration and nanofibers, which is used in medical science, textiles and papermaking, non- ... Method for preparing nano-fiber-based guided bone regeneration membrane. A technology for guiding bone regeneration and ... and the HA-g-PLLA/PLGA composite fiber membrane has a broad application prospect in the treatment of guided bone regeneration. ... the novel biodegradable guided bone regeneration membrane is constructed. Compared with PLGA and HAP/PLA fiber membranes, the ...
New Ceramic Scaffolds Can Influences the Activities of Specific Primary Cells and Boost Bone Regeneration. ... To find and develop a biomaterial that can speed up the growth rate of the injured bones counts. There are a great number of ... found a new type of ceramic scaffold that is highly potential to be applied as biomaterial to boost bone regeneration. And the ... Macrophages are the primary cells influenced by the ceramic scaffold and are of greater power to grow make the injured bone ...
Interests: advances in material research; bone regeneration; materials; periodontal regeneration. Special Issues, Collections ... Special Issue in Materials: Advanced Dental Materials for Periodontal and Bone Regeneration. Special Issue in Applied Sciences ... Interests: biphosphonate inducing oral bone necrosis; oral cancer managements; oral pathology; oral laser surgery. Special ...
... and also the relationship between bone tissue regeneration and mechanical stimulation, and thereby inform conditions for bone ... In silico study of bone tissue regeneration in an idealised porous hydrogel scaffold using a mechano-regulation algorithm Feihu ... In this study, we investigated bone tissue regeneration in an idealised hydrogel scaffold using a mechano-regulation model ... in silico bone tissue engineering, mechanical stimulation, mechano-regulation algorithm. College: Faculty of Science and ...
Grant to Support Bone Tissue Regeneration Research. Hossein Bassir, DDS, DMSc, of the Stony Brook School of Dental Medicine, ... Magnesium Hydroxide Improves Bone Regeneration and Function. Research at the University of Queensland School of Dentistry could ... Live Bone Grown in the Ribs to Repair Craniofacial Injuries. A multi-university team of researchers have developed a technique ... Therapies Put the Bodys Own Repair Processes to Work in Regenerating Bone. Researchers at the University of Iowa College of ...
keywords = "Adipose Tissue/growth & development, Animals, Bone Regeneration/genetics, Bone and Bones/metabolism, Cartilage/ ... N2 - Tissue engineering strategies promote bone regeneration for large bone defects by stimulating the osteogenesis route via ... AB - Tissue engineering strategies promote bone regeneration for large bone defects by stimulating the osteogenesis route via ... Tissue engineering strategies promote bone regeneration for large bone defects by stimulating the osteogenesis route via ...
Dive into the research topics of Impact of recombinant platelet-derived growth factor BB on bone regeneration: A study in ... Impact of recombinant platelet-derived growth factor BB on bone regeneration: A study in rabbits. ...
... on bone healing have revealed that they affect bone regeneration negatively. The exact mechanism by which this adverse effect ... Evaluation of the effects of the systemic proton pump inhibitor-omeprazole on periimplant bone regeneration and ... Bone defects created half of the implant length circumferencial after implant insertion and defects filled with bone grafts. ... Evaluation of the effects of the systemic proton pump inhibitor-omeprazole on periimplant bone regeneration and ...
... implant insertion in horizontally atrophic ridges using a double template concept and one-stage guided bone regeneration (GBR) ... in cases of bone fenestration with autologous bone, anorganic bovine bone arranged in layers, or in cases of thin buccal bone, ... in cases of bone fenestration with autologous bone, anorganic bovine bone arranged in layers, or in cases of thin buccal bone, ... using a mix of 20% autologous bone and 80% anorganic bovine bone pro-tected with a resorbable collagen membrane. After 6 months ...
Guided Bone Regeneration from Socket Management to Horizontal Augmentation presented by Dr. Alan M. Meltzer. Learning ... VSOP Fall Meeting: Guided Bone Regeneration from Socket Management to Horizontal Augmentation presented by Dr. Alan M. Meltzer ... Meltzer lectures both nationally and internationally on the subjects of implant design, periodontal regeneration, guided bone ... Meltzer is also the author of a book chapter on implants and bone repair as well as the co-author of a text with Dr. Kevin ...
Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect - Texas A&M University (TAMU) Scholar profile, ... Mechanical stimulation has a positive impact on bone regeneration by activating cellular pathways that increase bone formation ... Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical ... Piezoelectric materials facilitate bone regeneration either by accumulating electric charge in response to mechanical stress, ...
keywords = "animal experiments, biomaterials, bone regeneration, bone substitutes, guided tissue regeneration, wound healing", ... Objectives: This study used a dog model to evaluate two antimicrobial protocols with or without guided bone regeneration (GBR) ... The effects of the implant site, early exposure, and type of antimicrobial protocol on bone regeneration were also evaluated. ... The effects of the implant site, early exposure, and type of antimicrobial protocol on bone regeneration were also evaluated. ...
Bosshardt, D. D., Stadlinger, B., and Terheyden, H. (2015). Cell-to-cell communication -periodontal regeneration. Clin. Oral ... Epithelial Bone Morphogenic Protein 2 and 4 Are Indispensable for Tooth Development. Haibin Mu1,2, Xin Liu1, Shuoshuo Geng1, ... Citation: Mu H, Liu X, Geng S, Su D, Chang H, Li L, Jin H, Wang X, Li Y, Zhang B and Xie X (2021) Epithelial Bone Morphogenic ... 2016). Transgenic expression of Dspp partially rescued the long bone defects of Dmp1-null mice. Matrix Biol. 52-54, 95-112. doi ...
Bone Regeneration and Repair * Imaging * Infections * Inflammation * Kinesiology * Knee: Cartilage * Meniscal Injury ...
1. Autologous Cell Therapies for Bone Tissue Regeneration Vunjak-Novakovic, Gordana; Kregar-Velikonja, Nevenka; Krecic-Stres, ...
3 Postdoc positions and 3 Group Leader positions within research area of materials for bone tissue regeneration at Rudolfs ...
Bone lengthening is a bone regeneration technique with multiple clinical applications. One of the most common complications of ... The woven bone created during the healing of bone regeneration processes is characterized as being extremely inhomogeneous and ... Bone lengthening and bone transport are regeneration processes that commonly rely on distraction osteogenesis, a widely ... Introduction: Bone transport (BT) for segmentary bone defects is a well-known technique as it enables correction with new bone ...
Show author(s) (2013). A novel model: Microenvironmentally-induced carcinogenesis for screening bone regeneration scaffolds. ...
FYI is bone regeneration... Its also Earth pulse.... But, 7 Hz is yours FIIISH, also you as everyone else should be running ...
  • To assess bone tissue engineering in vivo , the computer-designed, circular PLGC scaffold was implanted into a full-thickness cranial bone defect and monitored by micro-computed tomography (CT) and histology of the in vivo tissue-engineered bone. (
  • Engineering new bone tissue to repair and regenerate bone at bone defect sites represents one of the most challenging emergent fields 1 . (
  • The scaffold consists of three-dimensional (3D) interconnected pores that allow for uniform penetration of nutrients and removal of metabolic waste in vivo to assist the development of new bone tissue 4 . (
  • He also runs an NIH-funded research lab that's focused on the cellular and molecular mechanisms that govern skeletal development and fracture healing, the effect of mechanical stimulation of bone regeneration and stem cell-based tissue engineering strategies to enhance bone regeneration. (
  • When implanted in rats with bone defects, the cylindrical scaffold promoted the regeneration of bone that was denser, more voluminous and more like the surrounding tissue than that achieved by many other state-of-the-art designs. (
  • The implant spurred regeneration even without the aid of externally sourced stem cells or so-called growth factors, which help promote healing but can also introduce regulatory complications and side effects that range from inflammation to unchecked tissue formation. (
  • But engineers were often struggling to craft pores large or organized enough for cells to consistently pass through and subsequently form the tendrils of tissue that make up bone. (
  • Gum disease has traditionally been treated by eliminating the gum pockets by trimming away the infected gum tissue and by re-contouring the uneven bone tissue. (
  • One of these advancements is guided bone regeneration, also referred to as guided tissue regeneration. (
  • To address these pockets, Progressive Periodontics may recommend tissue regeneration. (
  • During this surgical procedure, the pockets are cleaned thoroughly, and a membrane is installed between the soft tissue and the pocket in the bone. (
  • The membrane covers the pocket so that fast-growing soft tissue is blocked, and slower-growing bone and attachment between bone and tooth, can begin to grow, or "regenerate" itself. (
  • The principles of guided tissue and bone regeneration are covered intimately , including many recent advancements in barrier membrane technologies also as use of platelet-rich fibrin and various growth factors, and lots of next-generation materials which will optimize future bone and periodontal regeneration are presented. (
  • To overcome the limitations of current treatments, the lead collaborators developed a new technology, called SonoHeal, that attracts and activates endogenous tissue stem cells to regenerate bone and heal fractures. (
  • abstract = "Successful repair of craniofacial and periodontal tissue defects ideally involves a combined therapy that includes inflammation modulation, control of soft tissue infiltration, and bone regeneration. (
  • In this study, an anti-inflammatory polymer, salicylic acid-based poly(anhydride-ester) (SAPAE) and a three-dimensional osteoconductive ceramic scaffold were evaluated as a combined guided bone regeneration (GBR) system for concurrent control of inflammation, soft tissue ingrowth, and bone repair in a rabbit cranial defect model. (
  • Additional work is warranted to optimize the anti-inflammatory action of the SAPAE, GBR suppression of soft tissue infiltration, and stimulation of bone formation in the scaffolds and create a composite device for successful repair of craniofacial and periodontal tissue defects. (
  • Objective: The use of methods for tissue regeneration has been widely applied in Implantology, in clinical situations with disabilities or anatomical limitations that prevent the placement of osseointegrated dental implants. (
  • Engineering vascularized scaffold-based bone tissue holds great promise for regeneration and repair of large bone defects but remains a significant clinical problem. (
  • It shows a marked deficit in muscle regeneration and large areas devoid of muscle fibers (white), as well as accumulations of fibrotic tissue (blue). (
  • With researchers like Sun and his team on the case, it's only a matter of time before we are making the fantasy of regrowing bone tissue a reality. (
  • NIBIB-funded researchers have developed a 3D-printed scaffold coated in aggrecan, a native cartilage component, to improve the regeneration of cartilage tissue in joints. (
  • Smoothened agonist sterosome immobilized hybrid scaffold for bone regeneration. (
  • Sun's team uses a small molecule, phenamil, to reduce inflammation and promote endogenous bone regeneration. (
  • An alternative approach is the use of bone morphogenetic protein (BMP) to induce bone regeneration. (
  • The bone morphogenetic protein-2 and S100A4 expression of PA-Col and PA-HA-Col constructs was significantly lower than the basal level expression of cells on PA scaffolds. (
  • The viability of a released bioactive factor, recombinant bone morphogenetic protein (rhBMP)-2, in vivo in a rat ectopic bone induction assay is demonstrated. (
  • In this work, we firstly used a computer-designed, solvent-free scaffold and human dental pulp stem cells (hDPSCs) to regenerate neo-bone within cranial bone defects. (
  • In general, bone defects are irregularly shaped. (
  • The NIDCR-supported work is part of an effort to find more effective ways to repair bone defects that arise from disease or injury. (
  • In the current study, the investigators placed the nanoparticle-releasing scaffold in mice that had skull bone defects. (
  • Our nanoparticle-packaged drugs could be useful in many clinical situations where bone grafting is required to treat non-healing skeletal defects and related bone pathologies," says study senior author Min Lee, PhD, a professor of biomaterials science at the University of California, Los Angeles. (
  • Success of the procedure is determined by use of a suitable scaffold, a structural support for osteoprogenitor cells and osteoinductive factors necessary to regenerate neo-bone at the site of bone defect 2 . (
  • Scientists have developed a bone-healing system in mice that prompts stem cells to regenerate bone at the site of injury. (
  • But because this procedure can cause infection or nerve damage, scientists have been exploring strategies to regenerate bone cells onsite, inside the body. (
  • The team, which recently detailed its findings in the journal Science Advances, has developed a biodegradable, nanofiber-based implant, or scaffold, whose design could better regenerate bone by effectively guiding the migration of recuperative cells to the injury site. (
  • The lead collaborators on this project have developed a biological therapy that can regenerate bone without the need for more complex surgical procedures, such as bone grafts and bone transport. (
  • A less invasive and potentially more effective approach is to harness a body's own bodily repair processes to quickly and efficiently repair and regenerate bone. (
  • Come hear one of the leading voices in periodontal regeneration and peri-implantitis, Sunil Thanik, DMD, MSD, discuss the science behind True Periodontal Regeneration with the PerioLase MVP-7 and the LANAP & LAPIP protocols. (
  • As periodontal disease progresses, pockets of degenerated bone develop in the jaw. (
  • In 2007, while pursuing her doctorate in biomedical technology at the University of California, Davis, she began working with a group of proteins known as bone morphogenic proteins to achieve bone and cartilage regeneration. (
  • MSCs are the most vital factor for effective cartilage regeneration. (
  • The scaffold guides MSCs and growth factors to the defect sites and strengthens cartilage regeneration. (
  • Results from the study published in Biomaterials 1 showed that the 3D-printed scaffolds with aggrecan improved cartilage regeneration ten times more than microfracture alone or in combination with a non-functionalized scaffold. (
  • Scaffolds are needed that can act as temporary templates for bone regeneration and actively stimulate vascularized bone growth so that bone grafting is no longer necessary. (
  • Cellular infiltration and bone formation in these scaffolds were evaluated to assess inflammation and bone repair capacity of the test groups. (
  • In this study, we prepared electrospun bioactive composite scaffolds combining hydroxyapatite, collagen (Col) and a synthetic polymer-PolyActive (TM)-to mimic naturally occurring extracellular matrix for in situ bone regeneration. (
  • The results of the study demonstrate that bioactive composite scaffolds prepared by electrospinning could find potential use in bone regeneration applications. (
  • Autologous transplantation with bone marrow-mesenchymal stem cells (BMSCs) could be a promising therapeutical approach but its effect on toxic chemical-induced neuropathy remains undetermined. (
  • These small holes stimulate the growth of new cartilage by triggering the release of native mesenchymal stem cells (MSCs) from the bone. (
  • This study will also collect bone marrow from autologous donors (donors who will later receive their own BMSCs) for further treatment. (
  • To collect bone marrow aspirates and biopsies from healthy subjects and autologous donors in order to produce BMSCs. (
  • Prospective autologous donors will also have blood tests to evaluate their own suitability for bone marrow donation. (
  • Thus, this study aimed to describe a clinical case approaching the methods, techniques, and materials used in guided bone regeneration applied to Implantology. (
  • The book begins with a review of the biologic background and applications of bone grafting materials utilized in dentistry. (
  • very similar to one implant size and shape can't be utilized for each indication in implant dentistry, one bone grafting material, barrier membrane, or protein cannot maximize regenerative outcomes altogether clinical situations. (
  • Biomaterials are employed to fill the gap when big missing or injuries happened to bones. (
  • In the images above, uptake of nanoparticles (green) into bone marrow stem cells clearly increases 4 hours (left) and 24 hours (right) after placement on the scaffold. (
  • Ideally, the thinking went, bone marrow stem cells would infiltrate those pores and eventually form tissues with an architecture similar to the native, adjacent bone. (
  • They also have a compressive strength in the range of cancellous bone. (
  • Both plants contain chemicals that can activate body cells, enhance bone formation and heal wounds in vitro. (
  • In addition, transcriptomic analysis revealed that in vitro differentiated osteoclasts from the bone marrow-derived macrophages of Prdx5Ko mice showed enhanced expression of several osteoclast -related genes . (
  • In the first year, we developed an in vitro multiscale model for optimizing the temporal combination of growth factors to promote bone regeneration, and developed a prototype of the 3D predictive modeling of bone forming. (
  • We have outlined strategies and metrics for evaluating the credibility of the proposed multiscale models to address the bone regeneration in vitro and in vivo. (
  • They have a hierarchical pore structure comprising interconnected macropores, with interconnect diameters in excess of the 100 μm that is thought to be needed for vascularized bone ingrowth, and an inherent nanoporosity of interconnected mesopores (2-50 nm) which is beneficial for the attachment of osteoprogenitor cells. (
  • The purpose of the Mechanisms of Organ Repair & Regeneration Meeting is to bring together experts from cancer, angiogenesis, development, stem cell biology and innate immunity to discuss and stimulate debate on injury response mechanisms and facilitate the building of cross-disciplinary approaches towards understanding kidney and urinary tract organ repair and regeneration. (
  • In the first area, emerging research uses deferoxamine, a drug that treats iron poisoning, to activate the hypoxia-induced factor-1α, which in turn promotes angiogenesis and bone regeneration. (
  • Neo-bone formation of more than 50% in both micro-CT and histology tests was observed at only PLGC scaffold with hDPSCs/OF. (
  • This is the peer reviewed version of the following article: Calciolari E, Mardas N, Dereka X, Kostomitsopoulos N, Petrie A, Donos N. The effect of experimental osteoporosis on bone regeneration: Part 1, histology findings. (
  • In vivo multimodal microscopy for detecting bone-marrow-derived cell contribution to skin regeneration. (
  • Bone-marrow (BM)-derived cells have been shown to be capable of aiding skin regeneration in vivo by differentiating into keratinocytes. (
  • Characterizing innate mechanisms of skin regeneration by stem cells in vivo is important for the area of stem cell biology. (
  • In this study, we investigate the use of novel in vivo imaging technology for characterizing the contribution of BM-derived cells to regeneration of the epidermis in mouse skin in vivo. (
  • In vivo multimodal imaging has great potential for characterizing the conditions under which BM-derived cells contribute to skin regeneration. (
  • Together, our study demonstrated that BMSC transplantation significantly improve axon regeneration in hexane-induced polyneuropathy by activating NGF-PI3K-Akt-mTOR-CREB signaling via two independent mechanisms. (
  • At a second step, BMP-6 plasmid is delivered to the MSCs via sonoporation - the use of transcutaneous ultrasound to transfer plasmid DNA across the cell membrane - resulting in BMP-6 protein expression at a physiological level to induce cell differentiation and promote the formation of new bone and fracture healing. (
  • Scientists from Drexel University found a new type of ceramic scaffold that is highly potential to be applied as biomaterial to boost bone regeneration. (
  • And the effect has been approved in their studies, but the reason why the ceramic scaffold can be used to achieve the enhanced regeneration ability is unknown and under further probing. (
  • Macrophages are the primary cells influenced by the ceramic scaffold and are of greater power to grow make the injured bone recover more quickly. (
  • Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration. (
  • Bioactive glass is an ideal material because it rapidly bonds to bone and degrades over time, releasing soluble silica and calcium ions that are thought to stimulate osteoprogenitor cells. (
  • Weight-bearing activities stimulate bone growth. (
  • The utmost goal of this project is to address the challenges implicated in bone regeneration by integrating biological experiments material engineering, and multi-scale modeling to systematically optimize the bone regeneration. (
  • The present study sought to understand whether BMSCs could improve axon regeneration in Hexane-caused polyneuropathies and attempted to understand the associated molecular mechanisms. (
  • The purpose of this funding opportunity is to invite qualified scientific investigators to submit applications on liver development and regeneration to fully define the molecular and cellular mechanisms underlying these processes in health and disease and to apply these findings to developing improved therapies for liver disease. (
  • The invention relates to the preparation of a hydroxyapatite-grafted polylactide/polylactic acid-copolymerized glycolic acid electrospun nano-fiber-based guided bone regeneration membrane. (
  • The membrane is prepared from a mixture of HA-g-PLLA (hydroxyapatite-grafted poly-L-lactic acid) nanoparticles and PLGA (poly(L-co-glycolic acid) by an electrospinning method, i.e., the novel biodegradable guided bone regeneration membrane is constructed. (
  • Compared with PLGA and HAP/PLA fiber membranes, the prepared HA-g-PLLA/PLGA composite fiber membrane has the advantages that high mechanical performance is achieved, the adhesion and ductility of osteoblasts on the surface of the membrane are superior to those of the other composite membranes, and the HA-g-PLLA/PLGA composite fiber membrane has a broad application prospect in the treatment of guided bone regeneration. (
  • Its powers may not rival Wolverine's, but a regenerative implant engineered by researchers at UNMC and University of Nebraska-Lincoln could help repair bone-deep damage following physical trauma, surgery or osteoporosis. (
  • An existing therapy uses BMP-2, but it is used mainly for spinal surgery rather than repair of long bones. (
  • Sun's team is researching more effective ways to use the body's own internal repair processes by tailoring a specific bone regeneration strategy to the specific cause(s) of bone damage. (
  • These two innovations could pave the way for treatments to rejuvenate and repair significant bone damage, even for older adults. (
  • As bone death occurs, a repair process takes place as dead bone is removed and replaced by new bone. (
  • 12. Impaired intramembranous bone formation during bone repair in the absence of tumor necrosis factor-alpha signaling. (
  • Bone morphogenic proteins offer promising opportunities for regenerative medicine, but they are very expensive - often prohibitively so for people in lower- and middle-income communities. (
  • In conclusion, we confirmed neo-bone formation within a cranial bone defect using hDPSCs and a computer-designed PLGC scaffold. (
  • Today's standard of care is to use bone grafts, where bone from another part of the body is transplanted into the damaged area. (
  • The activation of PI3K-Akt-mTOR-CREB signaling was observed and Akt and mTOR inhibitors were shown to attenuate BMSCS-promoted axon regeneration. (
  • 6. Interleukin-1 and tumor necrosis factor antagonists attenuate ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis. (
  • 13. Recombinant human platelet-derived growth factor-BB augmentation of new-bone formation in a rat model of distraction osteogenesis. (
  • Learn the importance of calcium in building strong bones. (
  • Calcium and weight-bearing physical activity are essential to healthy bone growth. (
  • Bones are strengthened by the nutrients in our food and one important nutrient is calcium. (
  • Calcium is the building block of bones. (
  • Fat-free and low-fat milk are high in calcium and vitamin D. Vitamin D is also important for bone growth and health. (
  • Pictures of foods that contain calcium and are good for bones. (
  • Calcium and vitamin D are essential for healthy bone growth and can be found in fat-free and low-fat milk, fat-free and low-fat milk products, some vegetables and other foods. (
  • Children and adults work together to create a collage while learning about the importance of calcium and physical activity for healthy bone development and growth. (
  • Lead a discussion on the importance of keeping bones strong and the variety of ways that families can keep bones healthy by eating foods with calcium (low-fat or fat-free milk, yogurt and cheese, fortified soy beverages, broccoli, soybeans) and by including physical activity into their daily routines. (
  • In a second area, Sun and his team are developing a specific bone regeneration strategy tailored to the specific needs associated with periodontitis-induced bone and tooth loss. (
  • Limitations associated with autografts - harvesting bone from elsewhere in the patient's body for use at the site of injury - include the need for an additional surgical procedure with the associated morbidity, increased bleeding and operating room time, acute pain during the procedure, and chronic pain post-implant. (
  • Its disadvantages include pain, multiple surgeries, poor patient compliance, inconvenience of the frame, risk of inducing bone malalignment, and a complicated procedure for the surgeon. (
  • One common procedure for cartilage restoration is the microfracture procedure, where damaged cartilage is removed, and small holes are created in the bone at the sites of cartilage removal. (
  • Bone marrow stromal cells (BMSCs) can be grown from bone marrow provided by healthy volunteers. (
  • Volunteer bone marrow donors for BMSCs are generally required to meet the same healthy history and infectious disease marker screening criteria as volunteer blood donors. (
  • The National Institutes of Health Clinical Center is interested in collecting bone marrow aspirates and biopsies from healthy volunteers to produce clinical-grade BMSCs to treat Clinical Center patients. (
  • The collected bone marrow will be processed into BMSCs at the National Institutes of Health. (
  • Repairing bone and cartilage in joints after an injury has been a long-standing challenge in the field of regenerative medicine. (
  • Typically, when bones or joints are seriously damaged, such as in multiple or complex fractures or in bones that are seriously compromised by age, disease, infection, or injury, the most common treatment is a bone-graft using one's own bone material. (
  • Severe bone fractures constitute a complex medical condition. (
  • Between 11 and 15 million bone fractures occur in the United States each year, and up to 12% of these fractures fail to heal with currently available medical strategies. (
  • The goal of this project is to develop the preclinical data necessary to enable first-in-human clinical trials to treat severe bone fractures. (
  • More than 1 million severe bone fractures each year fail to heal, resulting in non-union. (
  • More than 1 million severe bone fractures fail to heal each year in the United States, and most long bone fractures occur in people younger than 50 years of age. (
  • This includes bone, blood, and lymph tissues, as well as the tissues that give support and structure to the skin and internal organs. (
  • This study proposes a new function of Prdx5 in bone remodeling that may be used in developing therapeutic strategies for bone diseases . (
  • The SAPAE polymers suppressed inflammation and displayed no deleterious effect on bone formation. (
  • That's where we caught up with him to discuss ways to improve fracture repairs, why orthobiologics are key to advancing trauma care and what his research lab is doing to help bones heal. (
  • What role do growth factors and skeleton stem cells play in the bone healing process? (
  • To find and develop a biomaterial that can speed up the growth rate of the injured bones counts. (
  • Bones are in constant stages of growth and regeneration, even into adulthood. (
  • A biodegradable scaffold placed in the damaged area releases nanoparticles that deliver a bone-building drug to nearby stem cells, triggering targeted healing. (
  • 1 Molecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, United States. (
  • Among the fundamental features of the ideal material is the ability to promote bone regeneration. (
  • South Africa is rich in native flora, but no one had previously done scientific research on the potential of these plants to treat bone and cartilage diseases," explains Prof Motaung. (
  • A blood sample will be collected and tested for the abovementioned diseases and for other problems that may prevent bone marrow donation. (