Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
The physiological renewal, repair, or replacement of tissue.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Procedures for enhancing and directing tissue repair and renewal processes, such as BONE REGENERATION; NERVE REGENERATION; etc. They involve surgically implanting growth conducive tracks or conduits (TISSUE SCAFFOLDING) at the damaged site to stimulate and control the location of cell repopulation. The tracks or conduits are made from synthetic and/or natural materials and may include support cells and induction factors for CELL GROWTH PROCESSES; or CELL MIGRATION.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
The process of bone formation. Histogenesis of bone including ossification.
Renewal or physiological repair of damaged nerve tissue.
Repair or renewal of hepatic tissue.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
Diseases of BONES.
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
A preparation consisting of PLATELETS concentrated in a limited volume of PLASMA. This is used in various surgical tissue regeneration procedures where the GROWTH FACTORS in the platelets enhance wound healing and regeneration.
The grafting of bone from a donor site to a recipient site.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
Techniques for enhancing and directing cell growth to repopulate specific parts of the PERIODONTIUM that have been damaged by PERIODONTAL DISEASES; TOOTH DISEASES; or TRAUMA, or to correct TOOTH ABNORMALITIES. Repopulation and repair is achieved by guiding the progenitor cells to reproduce in the desired location by blocking contact with surrounding tissue by use of membranes composed of synthetic or natural material that may include growth inducing factors as well.
Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.
Bone loss due to osteoclastic activity.
Artificial substitutes for body parts and materials inserted into organisms during experimental studies.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
The physiological restoration of bone tissue and function after a fracture. It includes BONY CALLUS formation and normal replacement of bone tissue.
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
Tumors or cancer located in bone tissue or specific BONES.
Bone lengthening by gradual mechanical distraction. An external fixation device produces the distraction across the bone plate. The technique was originally applied to long bones but in recent years the method has been adapted for use with mandibular implants in maxillofacial surgery.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Restoration of integrity to traumatized tissue.
Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.
Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC
Submicron-sized fibers with diameters typically between 50 and 500 nanometers. The very small dimension of these fibers can generate a high surface area to volume ratio, which makes them potential candidates for various biomedical and other applications.
Nanometer-scale composite structures composed of organic molecules intimately incorporated with inorganic molecules. (Glossary of Biotechnology and Nanobiotechology Terms, 4th ed)
A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.
A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.
Biocompatible materials placed into (endosseous) or onto (subperiosteal) the jawbone to support a crown, bridge, or artificial tooth, or to stabilize a diseased tooth.
Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.
Hemorrhage into a canal or cavity of the body, such as the space covered by the serous membrane (tunica vaginalis) around the TESTIS leading to testicular hematocele or scrotal hematocele.
The air space located in the body of the MAXILLARY BONE near each cheek. Each maxillary sinus communicates with the middle passage (meatus) of the NASAL CAVITY on the same side.
Products made by baking or firing nonmetallic minerals (clay and similar materials). In making dental restorations or parts of restorations the material is fused porcelain. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Boucher's Clinical Dental Terminology, 4th ed)
The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.
Fractures of the skull which may result from penetrating or nonpenetrating head injuries or rarely BONE DISEASES (see also FRACTURES, SPONTANEOUS). Skull fractures may be classified by location (e.g., SKULL FRACTURE, BASILAR), radiographic appearance (e.g., linear), or based upon cranial integrity (e.g., SKULL FRACTURE, DEPRESSED).
Injuries to the lower jaw bone.
A biocompatible polymer used as a surgical suture material.
Intraoral OSTEOTOMY of the lower jaw usually performed in order to correct MALOCCLUSION.
Fractures of the lower jaw.
The bony deposit formed between and around the broken ends of BONE FRACTURES during normal healing.
A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Breaks in bones.
Insertion of an implant into the bone of the mandible or maxilla. The implant has an exposed head which protrudes through the mucosa and is a prosthodontic abutment.
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The thickest and spongiest part of the maxilla and mandible hollowed out into deep cavities for the teeth.
A group of phosphate minerals that includes ten mineral species and has the general formula X5(YO4)3Z, where X is usually calcium or lead, Y is phosphorus or arsenic, and Z is chlorine, fluorine, or OH-. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A continuous protein fiber consisting primarily of FIBROINS. It is synthesized by a variety of INSECTS and ARACHNIDS.
Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.
Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)
Tumors or cancer of the MANDIBLE.
A hollow part of the alveolar process of the MAXILLA or MANDIBLE where each tooth fits and is attached via the periodontal ligament.
Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.
A plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. The seed of Ricinus communis L. is the CASTOR BEAN which is the source of CASTOR OIL; RICIN; and other lectins.
The grafting or inserting of a prosthetic device of alloplastic material into the oral tissue beneath the mucosal or periosteal layer or within the bone. Its purpose is to provide support and retention to a partial or complete denture.
Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.
Materials fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems.
A CCN protein family member found at high levels in NEPHROBLASTOMA cells. It is found both intracellularly and in the EXTRACELLULAR MATRIX and may play a role in the regulation of CELL PROLIFERATION and EXTRACELLULAR MATRIX synthesis.
Elements of limited time intervals, contributing to particular results or situations.
Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.
Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.
Nonparasitic free-living flatworms of the class Turbellaria. The most common genera are Dugesia, formerly Planaria, which lives in water, and Bipalium, which lives on land. Geoplana occurs in South America and California.
Excision of all or part of the liver. (Dorland, 28th ed)
A dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)
Fractures of the femur.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
A network of cross-linked hydrophilic macromolecules used in biomedical applications.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Silicon polymers that contain alternate silicon and oxygen atoms in linear or cyclic molecular structures.
Preprosthetic surgery involving rib, cartilage, or iliac crest bone grafts, usually autologous, or synthetic implants for rebuilding the alveolar ridge.
Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.
A highly glycosylated and sulfated phosphoprotein that is found almost exclusively in mineralized connective tissues. It is an extracellular matrix protein that binds to hydroxyapatite through polyglutamic acid sequences and mediates cell attachment through an RGD sequence.
Propylene or propene polymers. Thermoplastics that can be extruded into fibers, films or solid forms. They are used as a copolymer in plastics, especially polyethylene. The fibers are used for fabrics, filters and surgical sutures.
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
An immature epithelial tumor of the JAW originating from the epithelial rests of Malassez or from other epithelial remnants of the ENAMEL from the developmental period. It is a slowly growing tumor, usually benign, but displays a marked propensity for invasive growth.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
The fibrous CONNECTIVE TISSUE surrounding the TOOTH ROOT, separating it from and attaching it to the alveolar bone (ALVEOLAR PROCESS).
The maximum compression a material can withstand without failure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p427)
Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
A family of Urodela consisting of 15 living genera and about 42 species and occurring in North America, Europe, Asia, and North Africa.
The farthest or outermost projections of the body, such as the HAND and FOOT.
Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A salamander found in Mexican mountain lakes and accounting for about 30 percent of the urodeles used in research. The axolotl remains in larval form throughout its life, a phenomenon known as neoteny.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Cells with high proliferative and self renewal capacities derived from adults.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Treatment of muscles and nerves under pressure as a result of crush injuries.
Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.
A mutant strain of Rattus norvegicus without a thymus and with depressed or absent T-cell function. This strain of rats may have a small amount of hair at times, but then lose it.
Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from:
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS. It regulates BONE MORPHOGENETIC PROTEIN signaling and is essential for PHYSIOLOGICAL ANGIOGENESIS.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)
A species of newt in the Salamandridae family in which the larvae transform into terrestrial eft stage and later into an aquatic adult. They occur from Canada to southern United States. Viridescens refers to the greenish color often found in this species.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
The surgical removal of a tooth. (Dorland, 28th ed)
Membranous appendage of fish and other aquatic organisms used for locomotion or balance.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Premature closure of one or more CRANIAL SUTURES. It often results in plagiocephaly. Craniosynostoses that involve multiple sutures are sometimes associated with congenital syndromes such as ACROCEPHALOSYNDACTYLIA; and CRANIOFACIAL DYSOSTOSIS.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
The flexible rope-like structure that connects a developing FETUS to the PLACENTA in mammals. The cord contains blood vessels which carry oxygen and nutrients from the mother to the fetus and waste products away from the fetus.
Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.
A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.
Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Elongated, spindle-shaped, quiescent myoblasts lying in close contact with adult skeletal muscle. They are thought to play a role in muscle repair and regeneration.
Characteristics or attributes of the outer boundaries of objects, including molecules.
Compounds based on fumaric acid.
Repair of the damaged neuron function after SPINAL CORD INJURY or SPINAL CORD DISEASES.
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
Surgical insertion of a prosthesis.
Numerical expression indicating the measure of stiffness in a material. It is defined by the ratio of stress in a unit area of substance to the resulting deformation (strain). This allows the behavior of a material under load (such as bone) to be calculated.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Introduction of substances into the body using a needle and syringe.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
Methods for maintaining or growing CELLS in vitro.
The surgical cutting of a bone. (Dorland, 28th ed)
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Proteins prepared by recombinant DNA technology.
Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.
A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
Transection or severing of an axon. This type of denervation is used often in experimental studies on neuronal physiology and neuronal death or survival, toward an understanding of nervous system disease.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS. It regulates BONE MORPHOGENETIC PROTEIN signaling and plays an essential role in EMBRYONIC DEVELOPMENT.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.

Enhancement of osteogenesis in vitro and in vivo by a novel osteoblast differentiation promoting compound, TAK-778. (1/883)

TAK-778 [(2R,4S)-(-)-N-(4-diethoxyphosphorylmethylphenyl)-1,2,4, 5-tetrahydro-4-methyl-7, 8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxyamide; mw 505.53], a novel osteoblast differentiation promoting compound, was characterized in vitro and in vivo models. TAK-778 at doses of 10(-6) M and higher promoted potently bone-like nodule formation in the presence of dexamethasone in rat bone marrow stromal cell culture. This was accompanied by increases in cellular alkaline phosphatase activity, soluble collagen release, and osteocalcin secretion. Under the culture conditions, TAK-778 also stimulated the secretion of transforming growth factor-beta and insulin-like growth factor-I, indicating that TAK-778 may exert regulatory effects on osteoblast differentiation via autocrine/paracrine mechanisms. Furthermore, the in vivo osteogenic potential of TAK-778 was studied in bony defect and osteotomy animal models, using sustained release microcapsules consisted of a biodegradable polymer, poly (dl-lactic/glycolic) acid (PLGA). Single local injection of TAK-778/PLGA-microcapsules (PLGA-MC) (0.2-5 mg/site) to rat skull defects resulted in a dose-dependent increase in new bone area within the defects after 4 weeks. When the pellet containing TAK-778/PLGA-MC (4 mg/pellet) was packed into place to fill the tibial segmental defect in rabbit, this pellet induced osseous union within 2 months, whereas the placebo pellet did not. In addition, single local application of TAK-778/PLGA-MC (10 mg/site) to rabbit tibial osteotomy site enhanced callus formation accompanied by an increase in breaking force after 30 days. These results reveal for the first time that a nonendogenous chemical compound promotes potently osteogenesis in vitro and enhances new bone formation during skeletal regeneration and bone repair in vivo and should be useful for the stimulation of fracture healing.  (+info)

Acceleration of increase in bone mineral content by low-intensity ultrasound energy in leg lengthening. (2/883)

The effect of ultrasound energy on bone has been studied for a long time. In particular, multiple effects of low-intensity ultrasound energy have recently been demonstrated experimentally, such as increases in bending strength of fracture callus, acceleration of soft callus formation and endochondral ossification of the callus at the fracture site, stimulation of aggrecan gene expression, or modulation of TGF-beta synthesis and increase of calcium uptake. Clinically, prospective, randomized, and double-blind trials showed the efficacy of low-intensity ultrasound beam stimulation in the acceleration of fracture healing, with a significant decrease in the time to healing. On the other hand, callotasis, a popular method for bone lengthening, requires much time for new bone formation, and an external fixator must be remain on the patient for a long period. This is one of the major problems of the callotasis technique. If ultrasound energy stimulation could accelerate the rate of callus formation in callotasis, the external fixator could be removed earlier, the treatment period could be shortened, and the patient could return to daily activities more quickly. We report on the use low-intensity ultrasound beam stimulation during leg lengthening with the callotasis method in which callus formation was poor.  (+info)

Bone morphogenetic proteins in human bone regeneration. (3/883)

Recently, the first clinical reports on bone regeneration by two recombinant human bone morphogenetic proteins (rhBMPs), BMP-2 and BMP-7 (also named osteogenic protein-1, OP-1) have been published (1-4). Although both BMPs were able to support bone regeneration, a significant variation in individual response was observed with both proteins. Animal studies and laboratory experiments reveal a number of conditions that influence the osteoinductivity of BMP, such as BMP concentration, carrier properties and influence of local and systemic growth factors and hormones. In this paper, these studies and the clinical reports are reviewed, and the conditions that modulate the BMP-dependent osteoinduction are discussed. The information may provide clues as to how the performance of recombinant human BMP as bone-graft substitute in humans can be improved.  (+info)

Bone marrow stromal cells: characterization and clinical application. (4/883)

The bone marrow stroma consists of a heterogeneous population of cells that provide the structural and physiological support for hematopoietic cells. Additionally, the bone marrow stroma contains cells with a stem-cell-like character that allows them to differentiate into bone, cartilage, adipocytes, and hematopoietic supporting tissues. Several experimental approaches have been used to characterize the development and functional nature of these cells in vivo and their differentiating potential in vitro. In vivo, presumptive osteogenic precursors have been identified by morphologic and immunohistochemical methods. In culture, the stromal cells can be separated from hematopoietic cells by their differential adhesion to tissue culture plastic and their prolonged proliferative potential. In cultures generated from single-cell suspensions of marrow, bone marrow stromal cells grow in colonies, each derived from a single precursor cell termed the colony-forming unit-fibroblast. Culture methods have been developed to expand marrow stromal cells derived from human, mouse, and other species. Under appropriate conditions, these cells are capable of forming new bone after in vivo transplantation. Various methods of cultivation and transplantation conditions have been studied and found to have substantial influence on the transplantation outcome. The finding that bone marrow stromal cells can be manipulated in vitro and subsequently form bone in vivo provides a powerful new model system for studying the basic biology of bone and for generating models for therapeutic strategies aimed at regenerating skeletal elements.  (+info)

Bone wound healing after maxillary molar extraction in ovariectomized aged rats: quantitative backscattered electron image analysis. (5/883)

The processes of bone wound healing after maxillary molar extraction in ovariectomized aged rats were examined by means of quantitative backscattered electron image analysis and energy-dispersive X-ray microanalysis. Six-month-old female rats were either sham-operated or underwent bilateral ovariectomy (OVX), and 60 days postoperatively, the maxillary first molars were extracted. On post-extraction days 7, 30, and 60, the dissected and resin-embedded maxillae were micromilled in the transverse direction through the extracted alveolar sockets, and new bone formation on the buccal maxillary bone surface and within the extracted alveolar sockets was examined. In both sham-operated control and OVX rats, new bone formation was recognized on the buccal bone surface, as well as within the extracted sockets, and increased daily through to day 60. In comparison to sham-operated controls, new bone formation in OVX rats was significantly decreased both on the buccal bone surface and within the extracted sockets. Our results suggest that bone wound healing by new bone formation after maxillary molar extraction is significantly decreased in OVX-induced osteoporosis.  (+info)

Healing of erosions in rheumatoid arthritis. (6/883)

Reports on healing of erosions in rheumatoid arthritis are rare. However, it is expected that repair of erosions should be seen more often during the period of extensive use of disease modifying antirheumatic drugs, especially in patients who experience sustained remission. Two such cases are described.  (+info)

A modular femoral implant for uncemented stem revision in THR. (7/883)

We present the early results of 142 uncemented femoral stem revisions using the modular MRP-Titan system. There were 70 cases with marked preoperative femoral bone defects (Paprosky type 2C and type 3); and bone grafts were used in 31 cases. At a mean follow-up of 2.3 years five cases were re-revised due to dislocation and two due to aseptic loosening. The mean Harris hip score improved from 37.4 preoperatively to 92.4. In 122 cases progressive bone regeneration on X-ray was seen; and no further osteolysis was observed.  (+info)

The Wagner revision prosthesis consistently restores femoral bone structure. (8/883)

The short-term results are reported for 43 hip revision operations with the long-stemmed Wagner prosthesis. The patients were followed-up for an average of 25 months. The Charnley scores were; pain 5.2, movement 4.0 and walking 4.0. All patients except one showed abundant new bone formation. The stem subsided more than 20 mm in 5 patients and in 22 the subsidence was less than 5 mm. The major complication was dislocation, which occurred in 9 patients; 8 of these were reoperated and from then on remained stable.  (+info)

DOI: 10.11607/prd.00.0510 The effect of the pure-phase beta-tricalcium phosphate (beta-TCP) Cerasorb on bone regeneration was evaluated in hollow titanium cylinders implanted in the posterior jaws of five volunteers. Beta-TCP particles were inserted inside the cylinders and harvested 6 months after placement. The density of the newly formed bone inside the bone-growing chambers measured 27.84% 24.67% in test and 17.90% 4.28% in control subjects, without a statistically significant difference. Analysis of the histologic specimens revealed that the density of the regenerated bone was related to the density of the surrounding bone. The present study demonstrates the spontaneous healing of infrabony artificial defects, 2.5 mm diameter, in the jaw. The pure beta-TCP was resorbed simultaneously with new bone formation, without interference with the bone matrix formation. (Int J Periodontics Restorative Dent 2003;23:69 77 ...
Bioceramics 19: The Effect of Lif-Maleic Acid Added Calcium Aluminate Bone Cement and Ca-PMMA Composite Bone Cement on Bone Regeneration in Rat Calvarial Defects
The aim of this experimental study was to evaluate the effect of bovine lactoferrin (bLF)-loaded gelatin microspheres (GM) used in combination with anorganic bovine bone on bone regeneration in surgically created bone defects around tooth implants. Twenty-four uniform bone defects were created in the frontal bone via an extraoral approach in 12 domestic pigs. Twenty-four implants were placed at the center of the defects. In eight animals one of these defects was filled with 0.3 mL anorganic bovine bone while the other was left empty. In four animals, all defects were filled with 3 mg/defect bLF-loaded GM and anorganic bovine bone. All the defects were covered with collagen membranes. All animals were sacrificed after 10 weeks of healing, and the implants with the surrounding bone defects were removed en bloc. Undecalcified sections were prepared for histomorphometric analysis. The mean total area of hard tissue was 26.9 +/- 6.0% in the empty defect group, 31.8 +/- 8.4% in the graft group, and ...
Objectives: Guided bone regeneration (GBR) is a commonly utilized surgical technique in the craniofacial region. The transcriptional mechanisms associated with this type of bone regeneration are not well understood. The aim of this study was to characterize the transcriptome associated with GBR of a critical-size calvarial defect in the rat. Material and methods: Critical-size calvarial defects were created in six Wistar strain rats and treated according to the principles of GBR. The tissue filling the regenerating defect was harvested at 7 and 14 days. Total RNA was extracted and microarray analysis was carried out to identify the differences in the transcriptome between days 7 and 14. Results: Gene ontology (GO) analysis of the genes up-regulated at day 7 showed that immature wound healing-related mechanisms, such as protein metabolism and cell proliferation, were upregulated at this time point. Furthermore, the immuno-inflammatory process was also up-regulated at the earlier time point. In ...
A common design constraint in functional tissue engineering is that scaffolds intended for use in load-bearing sites possess similar mechanical properties to the replaced tissue. Here, we tested the hypothesis that in vivo loading would enhance bone morphogenetic protein-2 (BMP-2)-mediated bone regeneration in the presence of a load-bearing PLDL scaffold, whose pores and central core were filled with BMP-2-releasing alginate hydrogel. First, we evaluated the effects of in vivo mechanical loading on bone regeneration in the structural scaffolds. Second, we compared scaffold-mediated bone regeneration, independent of mechanical loading, with alginate hydrogel constructs, without the structural scaffold, that have been shown previously to facilitate in vivo mechanical stimulation of bone formation.. Contrary to our hypothesis, mechanical loading had no effect on bone formation, distribution, or biomechanical properties in structural scaffolds. Independent of loading, the structural scaffolds ...
Fingerprint Dive into the research topics of Order versus Disorder: In vivo bone formation within osteoconductive scaffolds. Together they form a unique fingerprint. ...
DOI: 10.11607/prd.1175 This report describes a novel bone reconstructive technique based on guided bone regeneration for extensive three-dimensional hard tissue augmentation. This two-stage technique utilizes bioresorbable osteosynthesis plates, pins, and collagen membranes that form a physical barrier resembling a fence, which contains the bone graft biomaterials composed of a combination of deproteinized bovine bone matrix and autologous bone grafted from intraoral sites. This technique can result in significant bone regeneration with minimal patient discomfort. Four case reports are presented. Histologic analysis of specimens shows the presence of mature bone. This procedure yields favorable results for bone formation, implant placement, and patient satisfaction. (Int J Periodontics Restorative Dent 2013;33:129 136. doi: 10.11607/prd.1175 ...
Background/Aim. The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bone regeneration is based on the use of osteoinductive autogenous grafts as well as osteoconductive synthetic material, like a β-tricalcium phosphate. The aim of the study was to determine the quality and quantity of new bone formation after the use of autogenous bone and β-tricalcium phosphate in the model of calvarial critical-sized defect in rabbits with induced diabetes mellitus type I. Methods. The study included eight 4-month-old Chincilla rabbits with alloxan-induced diabetes mellitus type I. In all animals, there were surgically created two calvarial bilateral defects (diameter 12 mm), which were grafted with autogenous bone and β-tricalcium phosphate (n = 4) or served as ...
Bone morphogenetic proteins (BMPs) have been widely investigated for their clinical use in bone repair and it is known that a suitable carrier matrix to deliver them is essential for optimal bone regeneration within a specific defect site. Fused deposited modeling (FDM) allows for the fabrication of medical grade poly ε-caprolactone/tricalcium phosphate (mPCL-TCP) scaffolds with high reproducibility and tailor designed dimensions. Here we loaded FDM fabricated mPCL-TCP/collagen scaffolds with 5 μg recombinant human (rh)BMP-2 and evaluated bone healing within a rat calvarial critical-sized defect. Using a comprehensive approach, this study assessed the newly regenerated bone employing micro-computed tomography (μCT), histology/histomorphometry, and mechanical assessments. By 15 weeks, mPCL-TCP/collagen/rhBMP-2 defects exhibited complete healing of the calvarium whereas the non-BMP-2-loaded scaffolds showed significant less bone ingrowth, as confirmed by μCT. Histomorphometry revealed ...
The aim of this study is to investigate the influence of electro-magnetic stimulation on bone regeneration and the effect on bacterial infection. Electro-magnetic stimulation is a promising technique and a powerful tool for the enhancement of bone regeneration. To optimize the amplitude of the electric field and also the magnetic flux density norm a finite element analysis (FEM) simulation was investigated. In conclusion, we demonstrate that a simulation of an electro-magnetic stimulation in an already applied stimulation chamber with DC current could generate suitable values. Future aims include an additional optimization of the magnetic flux density due to the variation of the current. In order to achieve this, a parameter sweep with different diameters of the area of interest will be performed. ...
The treatment of intrabony defects is a real challenge in molar teeth as it is chronic, slowly progressing disease which needs timely intervention. Periodontal inflammation associated with intrabony defect is not a separate entity as it secondarily affects the pulp causing retrograde pulpitis. However, treatment of these lesions will be complicated due to extensive bone loss. The tooth was endodontically treated followed by periodontal surgery to eliminate the deep periodontal pocket and promote bone fill in osseous defect. PepGen P-15 composited with platelet rich plasma was utilized for enhancing bone formation. The combination of these graft materials provides synergistic effect on bone regeneration.
Guided Tissue Bone Regeneration is used for patients with gum disease that have bone loss and mobility, to restore their smile and secure their teeth. Dr. Ronald H. Watkins performs procedures to promote bone regeneration at our offices in Phoenix, AZ . Call us today to discuss your options for bone regeneration.
Bone tissue engineering and regenerative medicine are promising strategies for treating bone diseases and reconstructing bone defects. For many years research has been dedicated to understanding the biochemical environment that is required to encourage bone regeneration and the desired properties of biocompatible scaffold materials. These studies demonstrate the potential for stem cell based therapies for bone regeneration. However the field of tissue regeneration is faced with the specific challenge to develop novel tissue regeneration approaches to produce tissue that can simultaneously support loading, but is also porous to allow for cell migration and diffusion of nutrients into the regenerated tissue to maintain viability. Dr. McNamaras research group develop mechanobiology based approaches (compression, vibration, fluid flow and hydrostatic bioreactors) for bone tissue regeneration and apply these methods to overcome limitations of biomaterial based in vitro approaches for bone tissue ...
Guided tissue bone regeneration helps the body regenerate bone around the gums after gum disease. Call Drs. Szymanowski, Periodontists in Sacramento, CA.
Principles of Bone Regeneration 2012th Edition by Jona J. Sela , Itai A. Bab Principles of Bone Regeneration PDF is a timely publication that
TY - JOUR. T1 - Incisive canal cysts related to periodontal osseous defects. T2 - case reports.. AU - Mealey, B. L.. AU - Rasch, M. S.. AU - Braun, J. C.. AU - Fowler, C. B.. PY - 1993/6. Y1 - 1993/6. N2 - The incisive canal cyst is the most common non-odontogenic cyst of the oral cavity. While the cyst has frequently been described, the relationship between the lesion and adjacent periodontal osseous defects has rarely been reported. This paper describes the occurrence and treatment of incisive canal cysts in two patients with severe adult periodontitis on maxillary incisor teeth.. AB - The incisive canal cyst is the most common non-odontogenic cyst of the oral cavity. While the cyst has frequently been described, the relationship between the lesion and adjacent periodontal osseous defects has rarely been reported. This paper describes the occurrence and treatment of incisive canal cysts in two patients with severe adult periodontitis on maxillary incisor teeth.. UR - ...
To present knowledge, macrophages are found in all tissues of the human body. They are a cell population with high plasticity which come with a multitude of functions which appear to be adapted to the respective tissue niche and micro-environment in which they reside. Bone harbors multiple macrophage subpopulations, with the osteoclasts as classical representative of a bone resorbing cells and osteomacs as a bone tissue resident macrophage first described by the expression of F4/80. Both subtypes are found throughout all phases in bone healing. In vivo data on bone regeneration have demonstrated their essential role in initiating the healing cascade (inflammatory phase) but also of the later phases of healing (e.g. endochondral and intramembranous bone formation). To participate in such diverse processes macrophages have to be highly plastic in their functionality. Thus, the widely used M1/M2 paradigm to distinguish macrophage subpopulations may not mirror the comprehensive role of the dynamics ...
The growing science of hard-tissue engineering has introduced various principles and solutions to confront the challenge of bone reconstruction. The process of bone augmentation is mandatory for successful placement and integration of root form dental implants in atrophic jaws. Although different techniques have achieved a predictable amount of horizontal bone gain, vertical augmentation has proven to be a consistent challenge, with often less than desirable results.1 This is especially evident in the posterior mandible, where the inferior alveolar nerve further accentuates the limited amount of available bone height.2 Because of this lack of predictability, a large range of reconstructive techniques and materials have been used: onlay bone grafting, guided bone regeneration (GBR), and distraction osteogenesis to list a few. The advantages and disadvantages of each technique impart its applicability to particular circumstances.3,4 The gold standard, autogenous bone graft, has several ...
Springfield MA Periodontist offers guided bone & tissue regeneration to stabilize teeth or prepare the jaw for dental implants. 413-788-9058
With the aging population and the popularity of oral implants, how to promote or accelerate bone regeneration and repair bone defects is increasingly important...
Bone defects occur as a result of trauma, atrophy or resection of intraosseous lesions. Bone regeneration using autologous or biomaterial bone grafts has evolved enormously in recent decades. Several graft materials, including autografts, allografts, xenografts and alloplasts, have been used for bone augmentation. Synthetic bone, on the other hand, does not imply disease risk, lacks the capacity to promote osteogenesis and osseoinduction, but is a great scaffold for bone neoformation. The healing of large bone defects is directly related to the size and time elapsed since the trauma, when more time elapses, greater is the healing and therefore the maturation of bone tissue. Osteogenesis, osseoinduction and osteoconduction are the three keys to osseointegration. Osteogenesis is the process by which new bone is formed from osteoprogenitor cells; osteoinduction is the stimulation and activation of the osteoprogenitor cells of the surrounding lesion tissue, and osteoconduction is the process by ...
BEGO Implant Systems GmbH & Co. KG, Bremen, Germany. The loss of volume of the alveolar ridge that regularly occurs after tooth extractions can compromise the hard and soft tissue situation for implants and thus the aesthetic outcome. The principle of membranesupported guided bone regeneration (GBR) is currently the most commonly used technique for bone regeneration in the dental practice. The separation of the rapidly proliferating soft tissue from the more slowly regenerating hard tissue creates a protected compartment in which damaged or lost bone tissue can be regenerated. Commercially available barrier membranes can be clearly differentiated from one another on the basis of several properties. Factors such as source tissue and preparation process have been just as exhaustively studied as the effect of the species from which the collagen was harvested or the networking properties. To what extent these factors are essential for the biodegradation time of a barrier membrane, for example, ...
BEGO Implant Systems GmbH & Co. KG, Bremen, Germany. The loss of volume of the alveolar ridge that regularly occurs after tooth extractions can compromise the hard and soft tissue situation for implants and thus the aesthetic outcome. The principle of membranesupported guided bone regeneration (GBR) is currently the most commonly used technique for bone regeneration in the dental practice. The separation of the rapidly proliferating soft tissue from the more slowly regenerating hard tissue creates a protected compartment in which damaged or lost bone tissue can be regenerated. Commercially available barrier membranes can be clearly differentiated from one another on the basis of several properties. Factors such as source tissue and preparation process have been just as exhaustively studied as the effect of the species from which the collagen was harvested or the networking properties. To what extent these factors are essential for the biodegradation time of a barrier membrane, for example, ...
Bone regeneration and graft is used in dentistery, especially for the dental implant treatment when the bone volume is not adequate.
Regeneration is a process of restoring the biological object structure after its damage. There are three types of bone regeneration: physiological, re
TY - GEN. T1 - Peptide amphiphiles for bone regeneration. AU - Mata, Alvaro. AU - Geng, Yanbiao. AU - Henrikson, Karl. AU - Sergeant, Tim. AU - Aparicio, Conrado. AU - Satcher, Robert L.. AU - Stupp, Samuel I.. PY - 2008/12/1. Y1 - 2008/12/1. UR - UR - M3 - Conference contribution. AN - SCOPUS:84869029925. SN - 9781615670802. T3 - 8th World Biomaterials Congress 2008. BT - 8th World Biomaterials Congress 2008. T2 - 8th World Biomaterials Congress 2008, WBC 2008. Y2 - 28 May 2008 through 1 June 2008. ER - ...
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The overall aim of this thesis was to establish whether selected Leeds β-structure self- assembling peptides were suitable candidates for use in skeletal tissue engineering. This was addressed by first carrying out simple cytotoxicity studies on selected SAPs using an osteosarcoma cell line in vitro, followed by assessing extent of bone regeneration / repair and safety in vivo in a rabbit calvarial defect model. In vitro investigations revealed that the SAPs (P11-4, P11-8, P111-12, P11-1S, P11-16 and Pl1- 20) tested were cytocompatible, though the positively charged SAP P11-16 performed less well than other SAPs tested in the contact cytoxicity assay, possibly due to the presence of chemical contaminant introduced during the peptide purification process. Cell proliferation was generally superior on the negatively charged peptides compared with the positively charged peptides and cells appeared to thrive at the lower concentrations (30 mg/mL) of negatively charged SAPs compared with their ...
Monitoring Degradation Process of PLGA/Cap Scaffolds Seeded With Mesenchymal Stem Cells in a Critical-Sized Defect in the Rabbit Femur using Raman Spectroscopy Abstract.
In an article in PLoS Medicine Gert Meijer (University Medical Centre...Until recently say the authors the use of bone grafts from a differe...Given all these problems with bone grafts scientists have attempted t...In their article the authors review the available data on bone tissue ...,Are,scientists,making,progress,in,being,able,to,regenerate,bone,tissue?,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Professor Maher Almasri, Dean of the College will be presenting at the Dental Tribune Symposium, Istanbul, on 13 April 2019.. Details:. DT Sempozyum. The presentation will be about Our Patients Do Not Require Augmentation Anymore! Dogma vs. Reality.. Successful placement of dental implants revolves around the availability of adequate bone at the time of implantation, and resorption of the alveolar ridge adversely affects treatment success rates. Guided Bone Regeneration has been used to successfully augment implant sites, and the use of autogenous bone was previously considered the gold standard. However, donor site morbidity and other complications have led to exploration of alternative techniques. Concentrated Growth Factors have been increasingly used as graft materials, with or without other bone scaffolds, mainly because they contain the molecular proteins known as Growth Factors, which seem capable of positively influencing hard and soft tissue regeneration. Nevertheless, efforts are ...
An idea struck. What if we could tap into the bodys ability to regenerate bone to help cancer patients? It was a novel concept … or so I thought.. High-grade bone cancers used to be a death sentence. If a person was lucky, he would get a limb amputated and live a few more years. Then chemotherapy came along and suddenly 70 percent of younger patients with these aggressive bone cancers were surviving.. Doctors could now treat the cancer with chemo, remove the tumors, and replace the bone defect with metal implants. However, metal things tend to break and wear out. As people got older, they needed multiple surgical interventions to fix or replace the implants. That meant hospital stays, risk of complications, sometimes infection.. Instead of medical implants, what if we could use the bodys natural ability to regenerate bone?I couldnt wait to tell my mentor.. It is a great idea, he said. But not a new idea.. Turns out a professor in Japan had been exploring this idea for 25 years already. ...
MIT chemical engineers have devised a new implantable tissue scaffold coated with bone growth factors that are released slowly over a few weeks. When applied to bone injuries or defects, this coated scaffold induces the body to rapidly form new bone that looks and behaves just like the original tissue. This type of coated scaffold could offer a dramatic improvement over the current standard for treating bone injuries, which involves transplanting bone from another part of the patients body - a painful process that does not always supply enough bone. Patients with severe bone injuries, such as soldiers wounded in battle; people who suffer from congenital bone defects, such as craniomaxillofacial disorders; and patients in need of bone augmentation prior to insertion of dental implants could benefit from the new tissue scaffold, the researchers say. Its been a truly challenging medical problem, and we have tried to provide one way to address that problem, says Nisarg Shah, a recent Ph.D. ...
Crushed bone injuries are relatively uncommon compared to compound, oblique and transverse fractures, yet they typically occur in accidents where there is...
Cells, called osteochondroreticular (OCR) stem cells, were discovered by tracking a protein expressed by the cells. Using this marker, researchers at Columbia University Medical Center found that OCR cells self-renew and generate key bone and cartilage cells, including osteoblasts and chondrocytes.
Regenerative repair of craniomaxillofacial bone injuries is challenging due to both the large size and irregular shape of many defects. Mineralized collagen scaffolds have previously been shown to be a promising biomaterial implant to accelerate craniofacial bone regeneration in vivo. Here we describe inclusion of a 3D-printed polymer or ceramic-based mesh into a mineralized collagen scaffold to improve mechanical and biological activity. Mineralized collagen scaffolds were reinforced with 3D-printed Fluffy-PLG (ultraporous polylactide-co-glycolide co-polymer) or Hyperelastic Bone (90wt% calcium phosphate in PLG) meshes. We show degradation byproducts and acidic release from the printed structures have limited negative impact on the viability of mesenchymal stem cells. Further, inclusion of a mesh formed from Hyperelastic Bone generates a reinforced composite with significantly improved mechanical performance (elastic modulus, push-out strength). Composites formed from the mineralized collagen ...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
Learn about OSSIX Bone grafting material, OSSIX PLUS and OSSIX Volumax resorbable collagen and barrier membranes, and OSSIX Graft cortical and/or cancellous bone material.
The device incorporates a structurally stable membrane (4, 4′, 34, 35) that incorporates a surface (15) to be bonded to a tissue to be regenerated, specifically a vital bone (2, 22, 38, 39). Means (9, 5, 6, 25, 36) are additionally provided whereby the membrane (4, 4′, 24, 35) is movable for the regeneration with a certain pulling force and speed. According to the invention the membrane (4, 4′, 24, 35) has, on its surface facing the tissue or bone, means (16) for the biological anchoring and adhesion for tissue or bone cells. These means (16) for the biological anchoring of tissue cells are specifically bone cells, protein molecules and/or osteoblasts (17), as well as indentations (45, 46, 48) and surface peaks (50) of the membrane.
LADDEC is processed cancellous bone of bovine origin with structure and chemical composition similar to that of human bone. It is a safe biocompatible bone graft that provides an excellent osteoconductive scaffold for rapid regeneration of bone and remodeling of the graft into host bone.
Kunkel, Nadja; Wagner, Andrea; Gehwolf, Renate; Heimel, Patrick; Tempfer, Herbert; Korntner, Stefanie; Augat, Peter; Resch, Herbert; Redl, Heinz; Betz, Oliver; Bauer, Hans-Christian; Traweger, Andreas (2017): Comparing the osteogenic potential of bone marrow and tendon-derived stromal cells to repair a critical-sized defect in the rat femur. In: Journal of Tissue Engineering and Regenerative Medicine, Vol. 11, No. 7: pp. 2014-2023 ...
Non-healing skeletal defects are addressed in over 2.2 million surgical cases each year. Bone morphogenetic protein 2 (BMP2), the main growth factor for bone re...
Dr. Kammeyer continues to be on the leading edge of bone and tissue regeneration. Contact us at 623-556-5442 for further queries.
Principal Investigator:YOSHIOKA HIROTAKA, Project Period (FY):2014-04-01 - 2017-03-31, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Morphological basic dentistry
RODERIC (Repositori dObjectes Digitals per a lEnsenyament la Recerca i la Cultura) es el repositorio institucional de la Universitat de València. Se concibe como una ventanilla única para el acceso y la difusión de la producción digital de la Universitat. RODERIC responde al compromiso de la Universitat con el movimiento de acceso abierto al conocimiento adquirido con su adhesión a la Declaración de Berlín (30 Septiembre de 2008).
The last two decades have seen an explosion of knowledge and new techniques to regenerate periodontal tissues. Up until the 1980s most surgery was
Sigma-Aldrich offers abstracts and full-text articles by [A Tampieri, E Landi, F Valentini, M Sandri, T DAlessandro, V Dediu, M Marcacci].
Solutions Dental Implants offer soft tissue regeneration to encourage your bodys natural ability to regenerate bone and tissue. Call 623-556-5442
Reconstruction of craniofacial skeletal defects from both congenital and acquired etiologies can often present a daunting challenge. Contemporary strategies emp...
Dr Leandro Bolzoni from the University of Waikatos School of Engineering has been awarded a Health Research Council explorer grant worth $150,000.
Bone regeneration[edit]. EGF plays an enhancer role on osteogenic differentiation of dental pulp stem cells (DPSCs) because it ... These data suggests that DPSCs in combination with EGF could be an effective stem cell-based therapy to bone tissue engineering ...
Tissue regenerationEdit. Collagen scaffolds are used in tissue regeneration, whether in sponges, thin sheets, or gels. Collagen ... Type I: skin, tendon, vasculature, organs, bone (main component of the organic part of bone) ... doi:10.1016/j.bone.2009.10.035. ISSN 8756-3282.. *^ Guillerminet, F.; Fabien-Soulé, V.; Even, P. C.; Tomé, D.; Benhamou, C.-L ... "Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice". Osteoporosis International. 23 ...
Bone Regeneration and Repair. Totowa, New Jersey: Humana Press. 2005. pp. 225-239. ISBN 978-0-89603-847-9. ... bone graft or artificial bone substitute is packed between the vertebrae to help them heal together.[1] In general, fusions are ... or artificial bone substitutes-to help the bones heal together.[1] Additional hardware (screws, plates, or cages) is often used ... Harvesting of bone graft (if autograft is used) [3]. Within a few days[edit]. *Wound infections - risk factors include old age ...
"Autogenous injectable bone for regeneration with mesenchymal stem cells and platelet-rich plasma: tissue-engineered bone ... Kraus KH, Kirker-Head C (April 2006). "Mesenchymal stem cells and bone regeneration". Vet Surg. 35 (3): 232-42. doi:10.1111/j. ... Bone repair[edit]. Bone has a unique and well documented natural healing process that normally is sufficient to repair ... Within four weeks of placing the scaffold, newly formed bone begins to integrate with the old bone and within 32 weeks, full ...
Their potential and pitfalls for bone tissue regeneration and engineering". Nanomedicine: Nanotechnology, Biology and Medicine ... doi:10.1016/j.bone.2008.04.013. PMID 18541467.. *^ Dalton, Aaron (15 August 2005). Nanotubes May Heal Broken Bones. Wired. ... Haddon, Robert C.; Laura P. Zanello; Bin Zhao; Hui Hu (2006). "Bone Cell Proliferation on Carbon Nanotubes". Nano Letters. 6 (3 ... Motta, M.; Moisala, A.; Kinloch, I. A.; Windle, Alan H. (2007). "High Performance Fibres from 'Dog Bone' Carbon Nanotubes". ...
Osteoporotic bone marrow defect • Our Lady of Fatima University • Outer enamel epithelium • Painless Parker • Pakistan Medical ... Tooth regeneration • Tooth squeeze • Tooth Tunes • Toothache • Toothbrush • Toothpaste • Toothpick • Torus mandibularis • Torus ... palatinus • Traumatic bone cyst • Traumatic neuroma • Treatment of knocked-out (avulsed) teeth • Trench mouth • Treponema ...
Slow bone regeneration. This is particularly common in patients who smoke intensively during the lengthening process[citation ... Gavriil Ilizarov determined that bone fragments could be carefully pulled apart without disrupting their alignment. These bone ... 2. Solomin L.N. "Bases of osteosynthesis per bone with Ilizarov Apparatus", publishing office ELBI-Spb, 2005 3. Goldreyer M.M ... The apparatus he initially used was modified to support the lengthening of finger (phalanx) bones. The first experiments ...
Recombinant PDGF is used to help heal chronic ulcers and in orthopedic surgery and periodontics to stimulate bone regeneration ... In experiments, it new bone fully covered skull wounds in test animals and stimulated growth in human bone marrow stromal cells ... chronic ulcers and in orthopedic surgery and periodontics as an alternative to bone autograft to stimulate bone regeneration ... in orthopaedic bone repair and regeneration". Current Pharmaceutical Design. 19 (19): 3384-90. doi:10.2174/1381612811319190005 ...
The primary objective of the study was to better understand bone healing and bone tissue regeneration and to study the impacts ... The primary objective of the study is to examine the CDKN1a/p21 pathway and its role in the arresting bone regeneration in ... The study also intended to gauge certain agents capable of inducing bone healing and regeneration in spaceflight. The study ... "Tissue Regeneration-Bone Defect". "NASA'S ASTRO-MICE WILL TEST WHAT SPACE DOES TO YOUR GUT". "Rodent Research-7 (SpaceX-15)". " ...
... to collect and study the human temporal bone, and to encourage temporal bone donation. In 1992 the NIDCD National Temporal Bone ... and regeneration biology Cochlear implants Surgical therapy for otosclerosis Hair cell regeneration Hearing aids technology ... The DRF funded research led, in 1987, to the discovery of spontaneous regeneration of hair cells in chickens, thus igniting the ... CS1 maint: discouraged parameter (link) "What is the Registry?". National Temporal Bone Registry. Retrieved 7 January 2013. CS1 ...
They would have fewer side-effects, while still promoting muscle and bone tissue growth and regeneration. These claims are, ... broken bones and pain. Muscle atrophy results from a co-morbidity of several common diseases, including cancer, AIDS, ... when the patient has a primary injury such as an immobilized broken bone (set in a cast or immobilized in traction), for ...
"Bone muscle crosstalk targets muscle regeneration pathway regulated by core circadian transcriptional repressors DEC1 and DEC2" ... BHLHE41 knockout mice had increased post-natal regeneration of muscle after injury. However, these mice showed no deficits in ...
Cassidy JW (November 2014). "Nanotechnology in the Regeneration of Complex Tissues" (PDF). Bone and Tissue Regeneration ... Tissue engineering of bone, for example, will require a much more rigid scaffold compared to a scaffold for skin regeneration.[ ... "Bone in a bottle: Attempts to create artificial bone marrow have failed until now". The Economist. 7 January 2009. Amini AR, ... Artificial bone marrow: Bone marrow cultured in vitro to be transplanted serves as a "just cells" approach to tissue ...
September 2014 Cassidy, John W. (2014). "Nanotechnology in the Regeneration of Complex Tissues". Bone and Tissue Regeneration ... For example, when creating scaffolds to support the growth of bone, researchers may mimic osteoclast resorption pits. ...
This role could potentiate new therapeutic treatment in aid of bone regeneration and increasing bone volume. ... Bone homeostasis[edit]. Adenosine receptors play a key role in the homeostasis of bone. The A1 receptor has been shown to ... Regulate Bone Resorption II Adenosine A1R Blockade or Deletion Increases Bone Density and Prevents Ovariectomy-Induced Bone ... Bone homeostasis[edit]. The role of A3 receptor is less defined in this field. Studies have shown that it plays a role in the ...
Membranes used in guided bone regeneration (GBR) and grafting may be of two principal varieties: non-resorbable resorbable. ... Hence, if a bone defect needs to heal, the membrane separates it from the soft tissue, giving time for the bone cells to fill ... Simion M, Scarano A, Gionso L, Piattelli A (1996). "Guided bone regeneration using resorbable and nonresorbable membranes: a ... Wang HL, Boyapati L (March 2006). ""PASS" principles for predictable bone regeneration". Implant Dent. 15 (1): 8-17. doi: ...
The company focusses on bone regeneration. Traditionally, when repairing a severe bone break involving a void, new bone is ... bone morphogenetic protein-7) to initiate rapid bone formation". J Bone Miner Res. 12 (10): 1584-95. doi:10.1359/jbmr.1997.12. ... At the 2017 Healthcare Innovation Summit Africa he presented on bone regeneration technologies. In 2014 Duneas and Nuno Pires ... "Dr Nic Duneas Discusses Bone Regeneration Technologies From Africa - YouTube". IT News Africa. 19 September 2017. ...
The drug was recently used in a study to examine the role of platelet-transported serotonin in liver regeneration. Myleran is ... Grigg A, Gibson R, Bardy P, Szer J (1996). "Acute portal vein thrombosis after autologous stem cell transplantation". Bone ... As an adjunct therapy with cyclophosphamide for conditioning prior to bone marrow transplantation in adults and children >12 kg ... "Platelet-derived serotonin mediates liver regeneration". Science. 312 (5770): 104-7. Bibcode:2006Sci...312..104L. doi:10.1126/ ...
James Bone (April 12, 2016). The Curse of Beauty: The Scandalous & Tragic Life of Audrey Munson, America's First Supermodel. ... Owen Johnson (1916). The Woman Gives: A Story of Regeneration. Library of Alexandria. ISBN 978-1-4656-0301-2. "Beorge Bellows, ... " "known," "wife" The Woman Gives: A Story of Regeneration by Owen Johnson (Boston, Little, Brown, and Company, 1916). Thomas ...
Regeneration of the ventricular myocardium in amphibians. Becker RO, Chapin S, Sherry R. Nature. 1974 Mar 8;248(444):145-7. ... Ultimately, however, the use of electrotherapy for increasing bone healing has not been shown to be effective. Becker believed ... Electrical stimulation of partial limb regeneration in mammals. Becker RO, Spadaro JA. Bull N Y Acad Med. 1972 May;48(4):627-41 ... Mollon B, da Silva V, Busse JW, Einhorn TA, Bhandari M (November 2008). "Electrical stimulation for long-bone fracture-healing ...
Rothrauff BB, Tuan RS (2014). "Cellular therapy in bone-tendon interface regeneration". Organogenesis. 10 (1): 13-28. doi: ... The enthesis (plural entheses) is the connective tissue between tendon or ligament and bone. There are two types of entheses: ... In a fibrous enthesis, the collagenous tendon or ligament directly attaches to the bone. In a fibrocartilaginous enthesis, the ... Genin, Guy; Thomopoulos, Stavros (2017). "The tendon-to-bone attachment". Nature Materials. 16 (6): 607-608. doi:10.1038/ ...
There is a subtle distinction between 'repair' and 'regeneration'.[1][69][70] Repair means incomplete regeneration.[69] Repair ... bone marrow-derived mesenchymal stem cells (MSC) and (2) hematopoietic stem cells (HSC). Bone marrow also harbors a progenitor ... In some instances, after a tissue breakdown, such as in skin, a regeneration closer to complete regeneration may be induced by ... This type of regeneration is common in physiological situations. Examples of physiological regeneration are the continual ...
In the two lobes, hematopoietic precursors from the bone-marrow, referred to as thymocytes, mature into T cells. Once mature, T ... "Activation of thymic regeneration in mice and humans following androgen blockade". J Immunol. 175 (4): 2741-53. doi:10.4049/ ... Cells in the thymus can be divided into thymic stromal cells and cells of hematopoietic origin (derived from bone marrow ... Schwarz, B. A.; Bhandoola, A. (2006). "Trafficking from the bone marrow to the thymus: a prerequisite for thymopoiesis". ...
Geiger, M (2003). "Collagen sponges for bone regeneration with rhBMP-2". Advanced Drug Delivery Reviews. 55 (12): 1613-1629. ... bone (main component of the organic part of bone) Type II: cartilage (main collagenous component of cartilage) Type III: ... In bone, entire collagen triple helices lie in a parallel, staggered array. 40 nm gaps between the ends of the tropocollagen ... Collagen is used in bone grafting as it has a triple helical structure, making it a very strong molecule. It is ideal for use ...
... both of which are important in attaining alveolar bone growth in the area of desired regeneration.[7] ... Boyan, BD, et al. Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone ... It is still unclear exactly how EMD participates in the regeneration process.[5] But it has been demonstrated that EMD serves ... Hammarström, L. Enamel matrix, cementum development and regeneration. J Clin Perio 1997;24:658-68. ...
Quality of bone healing: Perspectives and assessment techniques. Wound Repair and Regeneration. 22(S1). Johnson Benjamin, ... Localized Low Dose rhBMP-2 Is Effective at Promoting Bone Regeneration in a Pre-Clinical Mandibular Segmental Defect Model. ... Biomask for skin regeneration. Regenerative Medicine. 9(3): 245-8. Guda Teja, Labella Carl, Chan Rodney, et al. 2014. ... Wound Repair and Regeneration. 21(2):A40-A40. Hale, Robert G. 2013. Challenges in Craniofacial Reconstruction Following Trauma ...
He examined the writings of surgeon Michele Troja who noted the regeneration of bone tissue at site. In 1852 he was able to ... Lazzeri, Davide; Gatti, Gian Luca; Romeo, Gianfranco; Balmelli, Bruno; Massei, Alessandro (2009). "Bone Regeneration and ... was an Italian surgeon who was a pioneer of bone surgeries who developed techniques for the removal of fragments of bone, so as ... He also designed surgical instruments for sectioning bones in-situ. Larghi was born in Vercelli to Francesco and Maria Giudice ...
January 2003). "Autologous bone-marrow stem-cell transplantation for myocardial regeneration". Lancet. 361 (9351): 45-6. doi: ... When comparing the rates of MSC in the bone marrow aspirates and bone marrow stroma, the aspirates tend to have lower rates of ... Bone marrow transplant is a form of stem cell therapy that has been used for many years because it has proven to be effective ... The quantity of bone marrow stem cells declines with age and is greater in males than females during reproductive years. Much ...
The material is used to stimulate natural bone regeneration. A clinical study of this technique detailed all patients within ... It is inserted during a sinus lift or augmentation and used to increase the amount of bone to support dental implants. Implants ... It also showed vertical bone gain in all subjects. Numerous different types of material have been used as sinus implants during ... Implants can be in conjunction with sinus surgery to treat chronic sinusitis and also in sinus augmentation to increase bone ...
1996) 4. Established the Laminar Air Flow Room and the Bone Marrow Transplantation Center. (1995) The hospital is accessible ... neural regeneration and repair, and epilepsy research and patient care of the nation. 3. Established National PET/Cyclotron ...
Other regeneration techniques[edit]. Current concerns with the high energy/cost nature of thermal regeneration of activated ... The most common regeneration technique employed in industrial processes is thermal reactivation.[59] The thermal regeneration ... some alternatives to thermal regeneration systems have been employed in industry. Current alternative regeneration methods are ... Per adsorption-thermal regeneration cycle between 5-15 wt% of the carbon bed is burnt off resulting in a loss of adsorptive ...
Alibardi, Lorenzo (2010). Morphological and cellular aspects of tail and limb regeneration in lizards a model system with ... The new section will however contain cartilage rather than bone, and will never grow to the same length as the original tail. ... a jaw joint formed by the quadrate and articular bones, and certain characteristics of the vertebrae.[17] The animals singled ... implications for tissue regeneration in mammals. Heidelberg: Springer. ISBN 978-3-642-03733-7. .. ...
October 2005). "Meniscal regeneration using tissue engineering with a scaffold derived from a rat meniscus and mesenchymal ... Osteoarthritis is a common condition of cartilage failure that can lead to limited range of motion, bone damage and invariably ... bone can be exposed in the joint. Some additional examples of cartilage failure mechanisms include cellular matrix linkage ... "Articular cartilage regeneration with autologous peripheral blood progenitor cells and hyaluronic Acid after arthroscopic ...
Later, when lead-making and bone-processing for soap and china came to be established, they too located in the East End rather ... of the last of the East End docks in the Port of London in 1980 created further challenges and led to attempts at regeneration ...
This agent also causes respiratory tract lesions, bone marrow depression, and eye damage, the epithelial tissues of these ... epithelial regeneration and mucous cell hyperplasia. Most of these abnormalities resolve with time. Functional changes ( ...
... is a bone-like matrix that is porous and yellow-hued material. It is made up of 70% inorganic materials (mainly ... It can have clinical significance during periodontal regeneration.. Circumpulpal dentin forms the majority of the dentin and is ... It is similar to osteoid in bone and is thickest when dentinogenesis is occurring.[1] ...
The fibrous connective tissue that connects bones to other bones and is also known as articular ligament, articular larua, ... regeneration. The process of renewal, restoration, and growth that makes genomes, cells, organisms, and ecosystems resilient to ... The field may also encompass the study of reproduction, regeneration, metamorphosis, and the growth and differentiation of stem ... regeneration.[1]. carbon fixation. Also called carbon assimilation. ...
animal organ regeneration. • positive regulation of cell proliferation. • positive regulation of cell size. • positive ...
"Blood and Thunder: Regeneration". Retrieved 2008-05-14.. *^ "Lady Antebellum 'Own' the Billboard 200 with ... Danzig and Mother Love Bone" sound the same.[203] ...
Skull bones[edit]. Methods from this group attempt to derive ICP from mechanical properties of the skull bones rather than of ... Neuroregeneration/Nerve regeneration. *Neuroplasticity/Synaptic plasticity *Long-term potentiation. *Long-term depression ... In Sinha's [14] method resonant frequency of the skull bones is determined first, then a sinusoidal excitation at the resonant ... as the bones strongly attenuate the transmission of the ultrasound at these frequencies. TCD is primarily a technique for ...
Because of this, my heart breaks within me, and my bones tremble; for even the day of death does not atone for such sins. ...
"Regeneration". James Genn. David Vainola. February 18, 2017 (2017-02-18). 3.141 (US)[36]. ... When up-and-coming baseball player Jaquan is diagnosed with a rare form of leukemia, he is desperate to find a bone marrow ...
Alveolar Bone[edit]. In periodontal health, the alveolar bone surrounds the teeth and forms the bony socket that supports each ... Guided bone regeneration. *Guided tissue regeneration. *Enamel matrix derivative. *Implant placement. *Lateral pedicle graft ... Within the cortical plates and dental sockets lies cancellous bone, a spongy or trabecular type bone which is less dense than ... Untreated, these diseases can lead to alveolar bone loss and tooth loss. As of 2013[update], Periodontal disease accounted for ...
animal organ regeneration. • cell morphogenesis. • positive regulation of cell proliferation. • hyaluronan metabolic process. • ... β down regulation and recruitment of bone marrow cells". Stem Cells. 37 (6): 791-802. doi:10.1002/stem.3000. PMID 30861238.. ... positive regulation of neuron projection regeneration. • positive regulation of interleukin-10 production. • positive ... "Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration". Molecular ...
Autografts (employing bone or tissue harvested from the patient's body). *Allografts (using bone or tissue from another body, ... Okahashi K, Sugimoto K, Iwai M, Oshima M, Samma M, Fujisawa Y, Takakura Y (June 2006). "Regeneration of the hamstring tendons ... Grafts are inserted through a tunnel that is drilled through the shin bone (tibia) and thigh bone (femur). The graft is then ... The two bright objects in this X-ray are screws in the thigh bone (above) and shin bone (below). ...
A common trend in the uses of MCTs is that they are generally used for self-defense mechanisms and in regeneration.[37] ... The bones of cholla that glowed there in their incandescent basketry pulsed like burning holothurians in the phosphorous dark ...
... zooxanthella content and tissue regeneration". Mar. Freshw. Behav. Phys. 38: 43-51. doi:10.1080/102362405000_57929.. ...
This is thought to be due to faulty regeneration of the facial nerve, a branch of which controls the lacrimal and salivary ... swelling and compression of the nerve in the narrow bone canal is responsible for nerve damage. Demyelination may not even be ... Another complication can occur in case of incomplete or erroneous regeneration of the damaged facial nerve. The nerve can be ...
Long JH, Qi M, Huang XY, Lei SR, Ren LC (June 2005). "[Repair of rabbit tendon by autologous bone marrow mesenchymal stem cells ... Fan H, Liu H, Wong EJ, Toh SL, Goh JC (August 2008). "In vivo study of anterior cruciate ligament regeneration using ... study proved that mechanical loading of the tendon callus during the remodelling phase leads to healing by regeneration.[7] ...
"Inflammation and Regeneration. 36 (24): 24. doi:10.1186/s41232-016-0029-y. PMC 5725936. PMID 29259697.. ... Bone RC, Balk RA, et al. (The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of ... Bone RC, Balk RA, et al. (The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of ...
Guided bone regeneration. *Guided tissue regeneration. *Enamel matrix derivative. *Implant placement. *Lateral pedicle graft ... It is attached to the alveolar bone (C) by the fibers of the periodontal ligament and to the soft tissue of the gingiva by the ... Unlike those in bone, however, these canals in cementum do not contain nerves, nor do they radiate outward. Instead, the canals ... Adler, C.J.; Haak, W.; Donlon, D.; Cooper, A. (2010). "Survival and recovery of DNA from ancient teeth and bones". Journal of ...
... found to support the placement of stem cells taken from bone marrow on the trachea as a way of stimulating tissue regeneration ...
bone mineralization involved in bone maturation. • positive regulation of peptidyl-tyrosine phosphorylation. • positive ... skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration. • positive regulation of protein secretion ...
WR is associated with abnormalities in bone maturation, and lipids and hormone metabolism.[93] Affected individuals exhibit ... regeneration, stem cells, and cancer. The most widely studied of the progeroid syndromes are Werner syndrome and Hutchinson- ... Dyskeratosis congenita, a rare progressive congenital disorder of the skin and bone marrow in some ways resembling progeria ... loss of bone mass; telangiectasia; and malignancies.[3][9] In fact, the prevalence of rare cancers, such as meningiomas, are ...
RBCs are formed in the red bone marrow from hematopoietic stem cells in a process known as erythropoiesis. In adults, about 2.4 ... Both of these growth factors have been shown to play a significant role in the repair and regeneration of connective tissues. ... They are produced and derived from multipotent cells in the bone marrow known as a hematopoietic stem cells. Leukocytes are ...
3D printing techniques have created a bone scaffold that enables human bone tissue to regenerate and then dissolves as the ... Synthetic bone substitutes can be used to replace the lost material, but making these tough enough for the job can be a ... Rickets can cause a childs bones to soften and become prone to fractures and irregularities. It can result from a vitamin D ... The scaffold consists of the same minerals that feature in natural bone. It can dissolve as the patient recovers and new ...
Guided bone regeneration typically refers to ridge augmentation or bone regenerative procedures; guided tissue regeneration ... guided bone regeneration is a reliable and validated procedure. Use of barrier membranes to direct bone regeneration was first ... Guided bone regeneration is similar to guided tissue regeneration, but is focused on development of hard tissues in addition to ... Guided bone regeneration (GBR) and guided tissue regeneration (GTR) are dental surgical procedures that use barrier membranes ...
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Often, when a patient loses teeth due to trauma or disease, bone loss ensues that makes it difficult or impossible to use ... Tags: Bone, Bone Graft, Dental Implant, Dentures, Implants, Platelets, Surgery, Teeth, Trauma, Wound, Wound Healing ... Often titanium mesh is used as a tent over the bone graft to support the grafts shape and volume while the new bone grows. ... To combat this problem, bone grafting, a surgical procedure that replaces bone, is often used to serve as a support for dental ...
Bone regeneration. By System Administrator 25th February 2005 10:20 am 15th December 2015 8:17 pm ... or bone grafts taken from a human donor, with the better healing properties of bone autografts, or bone grafts taken from the ... In addition to studying bone regeneration, the ability to look at detailed 3-D images of vascular networks can shed light on ... While a traditional bone scan can give a doctor some idea of a bones density, a micro-CT scan that provides high resolution 3- ...
The range of biomimetic approaches to promote bone growth that are at the core of current bone healing therapies need to more ... Designing bone healing therapies that better mimic regeneration. Mary Ann Liebert, Inc./Genetic Engineering News ... The range of biomimetic approaches to promote bone growth that are at the core of current bone healing therapies need to more ... designing-bone-healing-therapies-that-better-mimic-regeneration/. 2109/. Related Journal Article. http://dx.. doi.. org/. 10. ...
Guided bone regeneration is a technique used in dentistry to rebuild part of the bone in the jaw before performing implants and ... Guided bone regeneration is used in dentistry to rebuild part of the bone in the jaw. Chronic dental disease and tooth loss ... Guided bone regeneration (GBR) is a technique used in dentistry to rebuild part of the bone in the jaw, if necessary, before ... The process of guided bone regeneration can be monitored with periodic physical exams and X-rays to check on bone growth. ...
... is a procedure that has been used in dental surgery for over 20 years for the treatment of bone loss. It involves placing bone ... Guided bone regeneration (GBR) is a procedure that has been used in dental surgery for over 20 years for the treatment of bone ... Real-time-guided bone regeneration around standardized critical size calvarial defects using bone marrow-derived mesenchymal ... The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and ...
... circuit between miRNAs and osteogenic homeostasis is of great value for artificial skeletal regeneration for severe bone ... Osteogenesis originates from mesenchymal stem cells (MSCs) differentiating into mature osteoblasts and each period of bone ... with diverse osteo-related genes and endeavor to sketch the contours of potential manipulations of miRNA-modulated bone repair. ... which have been reported to play a crucial role in maintaining bone development and metabolism. ...
a-c, a′-c′ Bone regeneration after synovectomy of the 5th metatarsophalangeal joint of the left foot. The left panel shows the ... Bone and cartilage regeneration in rheumatology clinical practice. The results described above clearly show that not only ... The 2005 article by Ikari and Momohara clearly showed that methotrexate can induce bone regeneration [29], and many ... When the joint has the ability to regenerate the destroyed bone and/or articular cartilage, self-regeneration should occur ...
Bone marrow drives central nervous system regeneration after radiation injury. Jorg Dietrich,1,2,3,4 Ninib Baryawno,1,2,3 Naema ... Bone marrow-derived G-CSFR+ cells are critical for brain regeneration after radiation injury. (A) Schematic diagram of the ... While the exact mechanisms on how G-CSF-responsive cells from the bone marrow modulate brain regeneration remain to be ... See the related article at Bone marrow drives central nervous system regeneration after radiation injury. ...
"Effects of Choukrouns platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in ... Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation. Qi Li,1,2 Shuang Pan,3 Smit J. ... R. Dimitriou, E. Jones, D. McGonagle, and P. V. Giannoudis, "Bone regeneration: current concepts and future directions," BMC ... Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift," Oral Surgery, Oral Medicine, Oral ...
... in this study we aimed to further characterize bone regeneration induced by corticocancellous porcine bone, porcine bone blocks ... said, it shows comparable bone healing potential and bone blood supply [15]. Pobloth evidenced that sheep bone, however, ... Bone Regeneration in Iliac Crestal Defects: An Experimental Study on Sheep. Antonio Scarano,1 Felice Lorusso,2 Lorenzo Ravera,2 ... osteoblasts derived from the periosteum and/or adjacent bone and/or bone marrow) to the bone defect site and exclusion of cells ...
Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the ... IL-17-producing γδ T cells enhance bone regeneration Nat Commun. 2016 Mar 11;7:10928. doi: 10.1038/ncomms10928. ... Here we show that γδ T cells produce IL-17A, which promotes bone formation and facilitates bone fracture healing. Repair is ... IL-17A accelerates bone formation by stimulating the proliferation and osteoblastic differentiation of mesenchymal progenitor ...
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors Message Subject. (Your Name) has forwarded a page to you from ... Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors. By Giuliana Ferrari, Gabriella Cusella-, De Angelis, Marcello ... Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors. By Giuliana Ferrari, Gabriella Cusella-, De Angelis, Marcello ... Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into ...
Usually, bone fractures do not heal by a direct bridging of the fracture gap with newly formed bone (primary bone healing). ... Bone is a multifunctional organ, a biological material and is able to fully restore bone fractures without leaving a scar. ... However, in about 10% of the bone fractures, healing does not lead to a successful reunion of the broken bone ends. Intensive ... Im menschlichen Körper kommt es nach einem Bruch zu einer vollständigen Regeneration des Knochens, ohne dass eine Narbe nach ...
2013) Bone regeneration based on tissue engineering conceptions: A 21st century perspective. Bone Res 1:216-248. ... Phosphate graphene as an intrinsically osteoinductive scaffold for stem cell-driven bone regeneration. Anne M. Arnold, Brian D ... 2016) Graphene oxide as a scaffold for bone regeneration. Wiley Interdiscip Rev Nanomed Nanobiotechnol 9:e1437. ... Herein, we report phosphate graphene (PG) as a biomimetic class of stem cell scaffolds for bone regeneration that show ...
Bone Quality and Quantity Following Guided Bone Regeneration. Official Title Examining Bone Quantity and Quality Following ... Bone Quality and Quantity Following Guided Bone Regeneration. This study has been completed. ... a routine alveolar bone augmentation is done to enable a dental implant installation at this site.Guided bone regeneration (GBR ... The bone substitute provides a scaffold to alveolar regeneration by the hosts osteoblasts while the membrane prevents unwanted ...
Bone Repair and Regeneration Although most bone fractures have remarkable reparative potential to heal common injuries on their ... The scans of the healing allograft (left) are segmented to separate the allograft bone (middle) from the new bone that formed ( ... differentiation and/or remodeling signals into the injury site to facilitate bone regeneration. Based on the remarkable success ... Pictured Left: Schematic model of strategies that combine stem cell technology and gene therapy to tissue engineer bone as ...
Cartilage Soak Bone, Flesh & Cartilage tea Ingredients: Comfrey root*, White Oak bark*, Gravel root+, Black Walnut Hull+, ... Formally called Bone, Flesh & Cartilage tea) Ingredients (*Organic, +Wildcrafted): Comfrey root*, White Oak bark*, Gravel root+ ...
Bone regeneration potential of optimized genipin cross-linked polyvinyl alcohol-gelatin (PVA20) hydrogels was assessed by ... Micro-CT analysis showed 32.67% increased bone formation of PVA-GE hydrogel defect compared with negative control after 15 ... Bone formation was evident in micro-CT after 5 and 15 days of in vivo implantation period. ... method of crosslinking promises improved mechanical properties of PVA-GE hydrogel making it a potential scaffold for bone ...
Further, their promise as a novel nanomedicine is also elaborated with respect to their role in bone tissue engineering. Also, ... Further, their promise as a novel nanomedicine is also elaborated with respect to their role in bone tissue engineering. Also, ... Hence, MSNs based nanomaterials may serve as improved candidate biotemplates or scaffolds for numerous bone tissue engineering ... and improve functions of damaged tissues and organs by facilitating tissue regeneration. Various nanohybrids composed of ...
... have emerged as promising building blocks for constructing bone scaffolds. In this study, fibrous scaffolds (PGFS) were ... Preparation and characterization of fibrous chitosan-glued phosphate glass fiber scaffolds for bone regeneration. ... Derubeis AR, Cancedda R. Bone marrow stromal cells (BMSCs) in bone engineering: limitations and recent advances. Ann Biomed Eng ... These results suggest that PGFS could be promising scaffolds for bone regeneration applications. ...
YAG laser is effective for bone regeneration. The diode laser can also be used for bone regeneration around implants and ... Summarize a clinical case of bone regeneration using a diode laser.. *Discuss a clinical technique for treating periodontitis ... A technique will be presented for treating periodontitis and peri-implantitis with the ultimate goal of new bone for both tooth ... Provide a platform to stimulate future investigation into hard tissue regeneration using lasers. ...
Bone regeneration often requires cues from osteogenesis-inducing factors for successful outcome. N-acetyl cysteine (NAC), an ... and contiguous bone after 6 weeks of healing. In contrast, with sponge alone, only sparse and incomplete bone regeneration was ... N-acetyl cysteine as an osteogenesis-enhancing molecule for bone regeneration Biomaterials. 2013 Aug;34(26):6147-56. doi: ... Bone regeneration often requires cues from osteogenesis-inducing factors for successful outcome. N-acetyl cysteine (NAC), an ...
... has warned Parcell Laboratories that it mischaracterized its stem cell-based bone regeneration product as a human cell, tissue ... FDA challenges classification of stem cell-based bone regeneration product Shook Hardy & Bacon LLP ... has warned Parcell Laboratories that it mischaracterized its stem cell-based bone regeneration product as a human cell, tissue ...
Without new periodontal ligament formation, new attachment and bone regeneration is impossible. In the past, the difficulty had ... Guided Tissue Regeneration. Periodontal tissue regeneration was ingeniously solved with the advent of sub-gingival (sub-under, ... Innovations in regeneration. The last two decades have seen an explosion of knowledge and new techniques to regenerate ... Regeneration techniques were already understood from wound healing studies and knowledge of the cell types that "coded" for new ...
The focus of the research area Bone and Tissue Regeneration is to define the molecular and cellular mechanisms of bone ... regeneration as well as the interactions of immune and cancer cells within bone regeneration. Elucidated key factors are tested ... from bone marrow and cancellous bone for musculoskeletal tissue regeneration.. *Understanding of osteocyte biology, as these ... This will provide the basis for the development of targeted and better-defined therapeutic strategies for bone/cartilage loss ...
According to the invention the membrane (4, 4′, 24, 35) has, on its surface facing the tissue or bone, means (16) for the ... These means (16) for the biological anchoring of tissue cells are specifically bone cells, protein molecules and/or osteoblasts ... specifically a vital bone (2, 22, 38, 39). Means (9, 5, 6, 25, 36) are additionally provided whereby the membrane (4, 4′, 24, ... 35) is movable for the regeneration with a certain pulling force and speed. ...
  • Based on positive clinical results of regeneration in periodontology research in the 1980s, research began to focus on the potential for re-building alveolar bone defects using guided bone regeneration. (
  • Guldberg's team has used micro-CT imaging to study fracture healing and repair of large bone defects that can result from the removal of bone tumors or crushing injuries. (
  • Large bone defects are typically repaired with allografts because large structural pieces are available from human donors. (
  • A review of biomimetic strategies to help heal bone defects, with an emphasis on cell transplantation, is published in BioResearch Open Access , a peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers . (
  • When teeth are extracted, it often triggers significant bone resorption (the process by which the body breaks down bone) in the alveolar ridges, leading to defects. (
  • Of note, apprehending the sophisticated circuit between miRNAs and osteogenic homeostasis is of great value for artificial skeletal regeneration for severe bone defects. (
  • Although most bone fractures have remarkable reparative potential to heal common injuries on their own, or with well establish clinical interventions, the same is not true for large segmental defects caused by trauma or bone cancers. (
  • The essence of this technology is an allograft from a cadaver (i.e. femur, tibia), which remains the standard of care to bridge critical defects, and a recombinant adeno-associated virus (rAAV) surface coating that introduces angiogenic, cellular proliferation, differentiation and/or remodeling signals into the injury site to facilitate bone regeneration. (
  • It is estimated that the cumulative annual cost for the treatment of almost 15 million patients in the United States with bone disorders, 1.6 million traumatic fractures, and 2 million osteoporosis associated bone defects is about $ 45 billion ( O'Keefe and Mao, 2011 ). (
  • These results confirm the utility of CCN2 in the regeneration of intractable bone defects in vivo when the factor is incorporated into gelatin hydrogel. (
  • Therefore, the aim of this project is to test the in vivo bone regeneration potential of stem cells from human dental tissues in the calvarial bone defects in immunocompromised Nude rats. (
  • The least required number of animals will be used and 2 calvarial bone defects per animal will be prepared to reduce the total number of animals. (
  • 4] Karapati S, Hugson A, Kugelberg CF: Healing following GTR treatment of bone defects distal to mandibular 2nd molars after removal of impacted 3 rd molars. (
  • Distraction osteogenesis (DO) has been widely applied in the treatment of bone defects and deformities in orthopedics and craniomaxillofacial surgery 5 . (
  • Defects were created in the trabecular region of rat femurs, and filled with deproteinized bovine bone (DBB), hydroxyapatite (HA) or strontium-doped HA (SrHA) or left empty (sham). (
  • Histology revealed new bone, at 6 d, in all the defects. (
  • However, the ideal size of bone particles used to fill bone defects is ill-defined. (
  • Standard size bone defects in the femur and the tibia of experimental animals were filled with freeze-dried cortical bone allografts with particle sizes of 1-2mm, 800-500μm, 500-300μm, 300-90μm, 250-125μm, 125-106μm, 106 to 75μm and 75-25μm. (
  • Unfilled defects and those filled with autologous bone served as controls. (
  • Rapid healing of bone defects packed with particulate bone allografts in the range of 300 to 90μm indicates such allografts can be used effectively in the filling of bone defects. (
  • The angiogenesis and osteogenesis capacity of injectable hydrogels could be regulated by tuning the delivery of DFO and BMP-2 independently, resulting in vascularization and bone regeneration in cranial defects. (
  • The NuCress™ scaffold is an implantable device that promotes controlled, robust bone regeneration in fractures, gaps where bone is missing, and major injury defects, including previously untreatable catastrophic injuries. (
  • BONE GRAFTING MATERIAL OSSIX ® Bone is a sterile, biocompatible bone grafting material aimed to fill, augment, or reconstruct periodontal and bony defects of the maxillo-facial complex. (
  • Mammals, including humans, have these same pathways, and defects in them are associated with various human bone diseases, said the paper's lead author Scott Stewart , an associate member of the UO Institute of Molecular Biology. (
  • By experimenting with treatments and discerning their effect on healing bone defects, they found some - including some in use today - that actually hinder tissue regeneration. (
  • The findings may be a big step toward developing effective therapeutic treatments for bone skeletal defects, bone loss and osteoporosis. (
  • Current treatments for bone skeletal defects utilize bone morphogenetic protein-2, or BMP2, an FDA-approved bone-healing protein. (
  • Before this study, large bone defects in patients were difficult to treat with BMP2 or other existing products available to surgeons," Ting said. (
  • The combination of NELL-1 and BMP2 may be particularly valuable for healing local bone defects in people who have osteoporosis or for those taking medications, such as steroids, that can inhibit bone growth. (
  • The researchers' findings have potential to help millions who suffer from osteoporosis and other bone defects. (
  • Röhner E, Pfitzner T, Preininger B et al (2016) Temporary arthrodesis using fixator rods in two-stage revision of septic knee prothesis with severe bone and tissue defects. (
  • Implant loosening, bone healing failure, implant-associated infections, and large bony defects remain challenges in orthopedic surgery. (
  • Large segmental gaps in bone caused by trauma or disease are typically treated with bone grafts and stiff scaffolds to hold the fractured bone in place, but sometimes these defects fail to heal. (
  • In sheep with critical-sized segmental defects, scaffolds that reduced stress shielding around tibial fractures enhanced bone bridging compared to stiffer scaffolds and shielding plates. (
  • Scaffolds can be tuned to evoke specific mechanical and biological responses within bone defects, which could help guide regeneration. (
  • Three-dimensional (3D) titanium-mesh scaffolds offer many advantages over autologous bone grafting for the regeneration of challenging large segmental bone defects. (
  • In established non-unions and bone defects, bone grafting is a common procedure. (
  • Georgia Tech researchers used the new technique to help develop bone graft substitutes that combine the availability and structural integrity of bone allografts, or bone grafts taken from a human donor, with the better healing properties of bone autografts, or bone grafts taken from the patient. (
  • Georgia Tech's micro-CT imaging facility has been used to study tissue engineering approaches to enhance or replace the use of bone grafts clinically. (
  • In the article entitled " Biomimetics of Bone Implants: The Regenerative Road ," Derrick Wan, MD and a team of researchers from Stanford University School of Medicine and Stanford University, California, examine the mechanical stability of bone implants and the effectiveness and challenges of grafts based on soluble bone minerals, structural proteins that comprise the extracellular matrix, or implants containing active cell populations. (
  • As well as the use of synthetic materials in bone grafts, it has been suggested that stem cells taken from the bone marrow could promote the development of new blood vessels and bone formation in GBR. (
  • The researchers monitored the grafts for bone volume and bone mineral density every two weeks up until 10 weeks. (
  • However, although the rate of new bone formation was faster in group 3, when the researchers examined the grafts at the end of the study, they found that grafts involving the synthetic material did not form a strong connection with the natural bone. (
  • GBR is a surgical procedure that uses barrier membranes with or without particulate bone grafts or/and bone substitutes. (
  • Current treatments rely on surgical fixation of bone grafts or devices to impart structural stability at the site of injury. (
  • By coating materials such as hip implants, bone grafts or spinal cages in a thin layer of this polymer, we can encourage bone regeneration targeted on the areas where they're required. (
  • Although auto- and allogeneic bone grafts are excellent for healing such lesions, there are potential complications with their use. (
  • Whether used to replace autogenous bone entirely or expand autogenous grafts, bone substitute materials (BSM) must be effective for time-delayed procedures before dental implant insertion and for recipient site optimization at the time of implant placement (simultaneous procedures). (
  • The aim of the thesis, "Towards improved bone regeneration," was to investigate ways to improve tissue engineered endochondral bone grafts. (
  • In this thesis we improve the construction of these grafts by identifying a more stable cell source with more favorable in vitro expansion characteristics compared to current gold standard cells, and expand upon our understanding of how such constructs form bone in vivo by investigating the importance of collagen type X during this process. (
  • Together the studies in this thesis move our understanding and possible clinical applications for endochondral bone grafts forward. (
  • This new approach using cell therapy for bone regeneration is promising and could be used as an alternative for the classic gold standard treatment with bone grafts. (
  • An unlimited supply of materials for transplants like bone grafts would be a game-changer. (
  • In this surgical technique video, Dr. Tomohiro Ishikawa demonstrates, in great detail, the clinical step-by-step techniques required for successful GBR procedures utilizing a collagen membrane, titanium mesh and autogenous bone grafts. (
  • Xenogenic bone grafts are widely used since decades. (
  • Barrier membrane is utilized in GBR technique to cover the bone defect and create a secluded space, which prevents the connective tissue from growing into the space and facilitates the growth priority of bone tissue. (
  • In guided bone regeneration, the area of interest is carefully cleaned to remove dead and infected material and a membrane is placed over the bone. (
  • Soft tissue tends to fill in much faster than bone, making the use of a membrane critical, as otherwise the gap in the bone will fill in with new gum growth. (
  • The membrane may be resorbable in some procedures, gradually melting away as the new bone grows in, or it can be permanent, requiring another procedure to pull it out once the patient's jaw is sufficiently rebuilt. (
  • It involves placing bone graft material within an absorbable or non-resorbable membrane that is impermeable to epithelial cells and fibroblasts. (
  • The membrane used in GBR blocks soft tissue invasion and provides a chamber to guide the bone regeneration process. (
  • In particular, questions remain over the ideal type of barrier membrane and whether the addition of other materials to the bone graft to mimic or accelerate the normal process of bone formation are beneficial. (
  • It relies on an inert membrane covering a bone substitute placed over the bony site requiring augmentation. (
  • The bone substitute provides a scaffold to alveolar regeneration by the host's osteoblasts while the membrane prevents unwanted epithelial cells to migrate to the bony defect area. (
  • The device incorporates a structurally stable membrane (4, 4′, 34, 35) that incorporates a surface (15) to be bonded to a tissue to be regenerated, specifically a vital bone (2, 22, 38, 39). (
  • Means ( 9, 5, 6, 25, 36 ) are additionally provided whereby the membrane ( 4, 4′, 24, 35 ) is movable for the regeneration with a certain pulling force and speed. (
  • According to the invention the membrane ( 4, 4′, 24, 35 ) has, on its surface facing the tissue or bone, means ( 16 ) for the biological anchoring and adhesion for tissue or bone cells. (
  • These means ( 16 ) for the biological anchoring of tissue cells are specifically bone cells, protein molecules and/or osteoblasts ( 17 ), as well as indentations ( 45, 46, 48 ) and surface peaks ( 50 ) of the membrane. (
  • 2 . A process according to claim 1 , characterized in that the membrane ( 4 , 4 ′), prior to placing it on the tissue or vital bone ( 2 ), is provided with osteoblasts ( 18 ) on the surface ( 15 ) to be placed against the vital bone ( 2 ). (
  • 3 . A process according to claim 1 , characterized in that the membrane ( 4 , 4 ′) is moved away from the tissue or vital bone ( 2 ) by means of at least one magnet ( 9 ) or mechanical pulling means ( 5 , 6 ), at the speed of 0.5 to 2 mm per day. (
  • Inion GTR biodegradable membrane system from curasan is intended to be used as a barrier membrane in guided tissue regeneration and. (
  • RCM is a fully resorbable membrane made of highly purified porcine skin-sourced collagen, aimed for guided bone and tissue regeneration. (
  • Next, alveolar biomodification is performed to carry out guided bone regeneration and placement of a fibrin-rich plasma membrane. (
  • The use of barrier membrane alternatives has shown to be effective in cases of guided bone regeneration. (
  • However, a proper understanding of the interactions between the bone substitute and GBR membrane materials and the bone-healing environment is lacking. (
  • This study aimed to investigate the early events of bone healing and the cellular activities in response to a combination of GBR membrane and different calcium phosphate (CaP) materials. (
  • The combination of a bioactive membrane and CaP bone substitute material doped with Sr may produce early synergistic effects during GBR. (
  • Statement of significance The study provides novel molecular, cellular and structural evidence on the promotion of early bone regeneration in response to synthetic strontium-containing hydroxyapatite (SrHA) substitute, in combination with a resorbable, guided bone regeneration (GBR) membrane. (
  • What became apparent was that the addition of the game-changing TSV Gel to the 'cocktail' of Osteobiol Lamina cortical bone barrier, Gen-Os and membrane means that achieving our dental nirvana and reliably growing crestal bone has become that little bit easier and predictable. (
  • The principle of membrane-supported guided bone regeneration (GBR) is currently the most commonly used technique for bone regeneration in the dental practice (BOSSHARDT & SCHENK, 2010). (
  • As a rule, a bone defect is filled with bone substitute and a barrier membrane is applied to cover the bone substitute, which provides the necessary volume, while ensuring the membrane makes direct contact with the adjacent bone surface (BORNSTEIN et al. (
  • In the protected cavity beneath the barrier membrane, a stable blood clot can form that acts as the initial matrix for regeneration. (
  • A surgical procedure is required to remove the membrane once the regeneration is complete. (
  • The BEGO Collagen Membrane is a resorbable barrier membrane derived from collagen for use in guided bone and tissue regeneration. (
  • A biodegradable collagen membrane for restoring lost volume in guided bone and tissue regeneration procedures. (
  • Abstract: Packing of bone defect with particulate allografts is a commonly performed clinical procedure. (
  • Often titanium mesh is used as a tent over the bone graft to support the graft's shape and volume while the new bone grows. (
  • The authors decided to begin with a bone graft, followed by dental implants that would support the replacement teeth. (
  • They created a virtual 3D model of the patient's mouth and bony defect, then, with a computer program, determined the correct position and placement of the bone graft based on the desired location of replacement teeth. (
  • During surgery, the authors ensured the proper placement of the titanium mesh and bone graft with a positioning jig fabricated from a clear plastic mold that used the existing teeth to hold the mesh in place while it was being secured. (
  • These impede bone formation because they grow at a faster rate than bone can regenerate and this can result in soft tissue, rather than bone, occupying the graft site. (
  • In a study, researchers at King Saud University in Riyadh, Saudi Arabia, showed how 3D micro-CT could help advance the study of GBR, by more precisely revealing the first instance of new bone formation, and how it could be used to test alternative types of bone graft material. (
  • Available from Impladent, Ltd, OsteoTape is OsteoGen in a preformed bone graft matrix. (
  • MiniPlate Bone Fixation Kit is available from Impladent, Ltd. The MiniPlate Bone Fixation Kit includes graft, screws, titanium mesh and. (
  • For example, Sunstar's GUIDOR easy-graft CLASSIC Allograft Bone Grafting System is made up of beta-tricalcium phosphate granules that are. (
  • In this study, we present a pre-clinical evaluation of representative materials, 1) Orthovita Vitoss foam which is a commercially available cancellous bone graft substitute consisting of tricalcium phosphate composed of nanometer-sized pure β-tricalcium phosphate (β-TCP) particles and Type 1 bovine collagen (C) (β-TCP/C foam) and 2) β-TCP disks. (
  • Artificial bone was originally designed as a prosthetic material serving as an alternative to autogenous bone 1 graft material, which put an enormous burden on patients. (
  • Fixation devices such as guided bone regeneration membranes, collagen membranes, titanium mesh, and bone screws may be used to counteract mechanical stresses on the graft during healing. (
  • Over time, it is fully absorbed and, when mixed with autogenous bone graft material, bioactive glass doubles natural bone regeneration. (
  • The granules contain osseoconductive properties that facilitate bone growth on the ceramic surface and through the graft, and are. (
  • By creating an easily injectable micropellet construct, an injectable endochondral bone forming construct was developed which could be used in combinational therapies with compounds, such as Emdogain, to perhaps further improve the effectiveness of graft outcomes which are described in more detail below. (
  • PARTICULATE AUTOGRAFT OSSIX ® GRAFT Particulate Allograft products consist of cortical bone matrix and may be used in a variety of reconstructive, periodontal, and oral maxillofacial procedures. (
  • This two-stage technique utilizes bioresorbable osteosynthesis plates, pins, and collagen membranes that form a physical barrier resembling a fence, which contains the bone graft biomaterials composed of a combination of deproteinized bovine bone matrix and autologous bone grafted from intraoral sites. (
  • Perhaps this would be a good indication for a bioactive modifier incorporated into the bone graft like PRGF or rhBMP? (
  • In cases where augmentation materials used are autografts (tissue transfer from same person) or allografts (tissue from genetically dissimilar members of same species) the bone density is quite low and resorption of the grafted site in these cases can reach up to 30% of original volume. (
  • In a site with a lack of bone GBR is a surgical procedure that provides an augmentation in terms of volume for the insertion of dental implants. (
  • One technique of ridge augmentation is Guided Bone Regeneration (GBR). (
  • In such cases, a routine alveolar bone augmentation is done to enable a dental implant installation at this site.Guided bone regeneration (GBR) is a widely used technique used to augment edentulus bone ridges. (
  • Chapters cover developing treatment algorithms for tooth retention or implant placemen, maximizing treatment results with guided bone regeneration therapy, considerations for esthetic treatment options, and augmentation of the posterior maxilla. (
  • The combination of guided bone regeneration (GBR) and bone augmentation is an established procedure to restore the bone. (
  • Guided Bone Regeneration and Ridge Augmentation have become routine procedures to enhance the functional, biological and aesthetic outcome of dental implants. (
  • In the project, an RCT of 150 patients will compare the safety and efficacy of autologous cultured stem cells and calcium phosphate biomaterials with autologous bone grafting in alveolar bone augmentation prior to dental implants. (
  • This report describes a novel bone reconstructive technique based on guided bone regeneration for extensive three-dimensional hard tissue augmentation. (
  • The aim of this course is to recognise cases which may benefit from bone augmentation in conjunction with dental implant treatment, understand the principles of bone healing and regrowth. (
  • Synthetic bone is an unlimited source and a safe and proven scaffold for bone augmentation. (
  • Guided bone regeneration (GBR) and guided tissue regeneration (GTR) are dental surgical procedures that use barrier membranes to direct the growth of new bone and gingival tissue at sites with insufficient volumes or dimensions of bone or gingiva for proper function, esthetics or prosthetic restoration. (
  • Use of barrier membranes to direct bone regeneration was first described in the context of orthopaedic research 1959. (
  • The first application of barrier membranes in the mouth occurred in 1982 in the context of regeneration of periodontal tissues via GTR, as an alternative to resective surgical procedures to reduce pocket depths. (
  • Finally, to improve wound healing and bone stability, they applied fibrin membranes rich in platelets. (
  • Since resorbable membranes have a low space-making capability, it is necessary to use a biomaterial underneath them, to maintain space and to help the bone regeneration capabilities of the site. (
  • Periodontal tissue regeneration was ingeniously solved with the advent of sub-gingival (sub-under, gingival-gum) "barrier membranes," sort of minute subterranean band-aids. (
  • 2] Hammerle CH, Jung RE, Feloutzis A: A systematic review of the survival of implants in bone sites augmented with barrier membranes (guided bone regeneration) in partially edentulous patients. (
  • In some cases, it is indispensable to perform bone regeneration procedures and use barrier membranes to create such optimal conditions capable of favorably supporting the dental implant. (
  • Describe alternatives of barrier membranes in cases of guided bone regeneration. (
  • In the afternoon, after a wonderful seafood risotto lunch (other plates were available) in the local trattoria, we practised placing the new Osteobol Lamina flexible grade cortical bone grafting materials, membranes and pin placement on typodonts - the whole Khoury technique, in fact, but the most interesting thing was to manipulate the new thermosensitive TSV Gel for stabilisation of grafting materials at the site. (
  • Along with the stress for the patient of a second surgical procedure, during the removal of non-resorbable membranes the underlying regenerated tissue can be damaged and there is a risk of subsequent crestal resorption of the alveolar bone (PIHLSTROM et al. (
  • Non-resorbable membranes do offer the advantage of a temporally unlimited barrier function and the associated exclusion of the soft tissue from the area of the bone regeneration. (
  • Unlike non-resorbable membranes, resorbable membranes can only provide a limited barrier function to exclude soft tissue from the area of bone regeneration because the structural integrity of the membranes is disrupted as the resorption progresses (e.g. see SCHWARZ et al. (
  • RESORBABLE COLLAGEN MAMBRANES OSSIX PLUS ® and OSSIX ® VOLUMAX biodegradable collagen membranes are intended for use during the process of guided tissue regeneration (GTR) and guided bone regeneration (GBR) as a biodegradable barrier. (
  • Although regeneration of the damaged joints is considered very rare, accumulating evidence shows that it actually occurs in routine clinical practice as a result of strong inhibition of synovitis using highly potent medications. (
  • Trial with platelet-rich fibrin and Bio-Oss used as grafting materials in the treatment of the severe maxillar bone atrophy: clinical and radiological evaluations," European Review for Medical and Pharmacological Sciences , vol. 14, no. 12, pp. 1075-1084, 2010. (
  • Synthetic, resorbable scaffolds for bone regeneration have potential to transform the clinical standard of care. (
  • Summarize a clinical case of bone regeneration using a diode laser. (
  • Elucidated key factors are tested in preclinical animal models that represent established human bone diseases as well as in early clinical studies. (
  • There is a clinical need for developing new techniques for bone regeneration to avoid invasive grafting procedures. (
  • However, their ability to regenerate bone must be confirmed in vivo prior to their clinical application. (
  • Here, we present a multidisciplinary strategy for pre-clinical biocompatibility testing of biomaterials for bone repair. (
  • This experimental data will form the basis for clinical studies, using this material as an interesting bone substitute for guided bone regeneration. (
  • Cortical bone was chosen because it produced better clinical results than did cancellous bone. (
  • Therefore, the multiple biophysical and chemical cues provided by the nanofibrous structures, organic-inorganic compositions, and chemical and biochemical angiogenic and osteogenic inducing cues suggest the potential for clinical applicability of these hydrogels in bone tissue engineering. (
  • Prof. Kamal Mustafa from the Department of Clinical Dentistry at the University of Bergen in Norway is sponsoring and leading, together with Dr Cecilie Gjerde (University of Bergen) and Prof. Mariano Sanz (Complutense University of Madrid), a multicentre randomised controlled clinical trial (RCT) on stem cell bone building. (
  • The purpose of this investigation was to evaluate the technique of guided tissue regeneration on a clinical and histologic level for generating new bone adjacent to osseointegrated implants. (
  • Clinical and histologic results demonstrate that the principle of guided tissue regeneration is applicable to osteogenesis in humans. (
  • Analysis of tissue neogenesis in extraction sockets treated with guided bone regeneration: clinical, histologic, and micro-CT results. (
  • A UCLA research team has found a combination of proteins that could significantly improve clinical bone restoration. (
  • The first clinical observation of the effect of ultrasound on bone healing was reported in the 1950s (Corradi and Cozzolino, 1953). (
  • Using three clinical cases, the lecturer describes his step-by-step approach for guided bone regeneration (GBR) procedures in different clinical situations. (
  • Several peptides have been shown to support and stimulate the bone healing response and have been proposed as therapeutic vehicles for clinical use. (
  • The aim of this comprehensive review is to present the clinical and experimental studies analysing the potential role of peptides for bone healing and bone regeneration. (
  • Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications. (
  • Biomaterials for bone regeneration aim to promote osteogenicity and osseointegration 10 and are ideally biocompatible, biodegradable, and porous (promoting cell migration, oxygen, and nutrients). (
  • Guided bone regeneration is similar to guided tissue regeneration, but is focused on development of hard tissues in addition to the soft tissues of the periodontal attachment. (
  • The theoretical principles basic to guided tissue regeneration were developed by Melcher in 1976, who outlined the necessity of excluding unwanted cell lines from healing sites to allow growth of desired tissues. (
  • The destructive gum condition, chronic periodontists, in the susceptible individual results in the breakdown of both the connective tissues which attach the tooth, and the bone supporting the root. (
  • Guided tissue regeneration surgery can be applied here, aiming to regenerate the periodontal tissues. (
  • The new micro-CT scan technique simultaneously looks at both vascularization (the process by which blood vessels invade body tissues during repair) and mineralization (the process by which mineral crystals form to harden regenerating bone) by collecting three-dimensional images in vitro and in vivo. (
  • Stem cells differentiate into specialized cells, which lay down different tissues such as fibrous tissue, cartilage and bone. (
  • Porous nano-scaffolds provide for better opportunities to restore, maintain, and improve functions of damaged tissues and organs by facilitating tissue regeneration. (
  • The limitations of the traditional synthetic porous scaffolds which are often made out of metals, polymers, ceramics or even composite biomaterials, include incompatibility with native tissue structure and properties of bone tissues. (
  • The cells responsible for the regeneration offer new clues on how to regenerate tissues in humans. (
  • The researchers further investigated the developmental origin of OPCs and found that OPCs are derived from embryonic somites and reserved in niches of bone-forming tissues in adult animal as the source of osteoblasts. (
  • The study revealed that OPCs originate embryonic somites, develop through mesenchymal precursors to settle in niches of bone-forming tissues like the fish fin ray. (
  • Preliminary in vitro experiments have been performed to confirm the presence of stem cells in these dental tissues, including their bone regeneration potential. (
  • With regards to bone and soft tissues, the response to injury is no different than for other organs. (
  • Artificial bone was initially made of metals and solid ceramics for strength, but the rigidity of the materials made it difficult for artificial bone to blend into bone tissues, and it could not be used for children for a long period of time. (
  • Stem cells have the potential to develop into a variety of cell types including those that make up living tissues, such as bones. (
  • If these components are in place, regeneration of the tissues around the tooth may occur within a week or two," he says. (
  • That process impeded regeneration of other essential tissues around the tooth. (
  • That allowed for the regeneration of gum tissues. (
  • Unprecedented is the property of these biopolymers to deliver high-energy phosphate in the extracellular space to promote anabolic processes including extracellular matrix synthesis in bradytrophic tissues such as cartilage and mineralized bone. (
  • In contrast, bone (but also vasculature and cardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple cell and tissue types and, thus, possessing more complex design requirements. (
  • Here, we use bone-regeneration successes to highlight cartilage-regeneration challenges: such as selecting appropriate cell sources and scaffolds, creating biomechanically suitable tissues, and integrating to native tissue. (
  • Differences in the physiologic environment, metabolic rate, and cellular make-up of bone and cartilage have profound effects on the potential to engineer these tissues. (
  • The large articulating motion experienced by cartilage, but not bone, can damage newly developed tissues that do not possess required lubrication, compressive, or tensile properties. (
  • The second aim of the group was to acquire more knowledge about the properties of the tissues formed during bone healing process which could lead to understand the mechano-regulation of the biological process during fracture healing, by the application of our multi-method approach. (
  • BMPs, as promoters of the regenerative process, have the ability to induce de novo bone formation in various tissues, and many animal models have demonstrated their high potential for ectopic and orthotopic bone formation. (
  • A topical cream developed by Lyle Corporate Development, Inc., claims to encourage regeneration of tissues in the vulva that have undergone cellular hypoxia. (
  • Bone is a multifunctional organ, a biological material and is able to fully restore bone fractures without leaving a scar. (
  • However, in about 10% of the bone fractures, healing does not lead to a successful reunion of the broken bone ends. (
  • Usually, bone fractures do not heal by a direct bridging of the fracture gap with newly formed bone (primary bone healing). (
  • Heikkilä JT, Kukkonen J, Aho AJ, Moisander S, Kyyrönen T, Mattila K. Bioactive glass granules: a suitable bone substitute material in the operative treatment of depressed lateral tibial plateau fractures: A prospective, randomized 1 year follow-up study. (
  • Large non-union bone fractures are a significant challenge in orthopedic surgery. (
  • For instance, large bone fractures caused by trauma, cancer or osteoporosis may not heal and are termed non-union bone fractures. (
  • The insights from this study could one day be used to develop new treatments for bone fractures, post-surgical therapies and other ailments. (
  • Bone regeneration is the process whereby bone is able to (scarlessly) repair itself from trauma, such as fractures or implant placement. (
  • The current paper focuses on the ( in silico ) biology of the bone regeneration process, taking place after bone traumata such as fractures or implant placement. (
  • In vivo 3D micro-computed tomography (CT) allows tissue imaging and assessment in real time, meaning it has potential for monitoring the formation of new bone after GBR. (
  • In comparison to existing simulations of bone healing, this study approached the problem from a more physical viewpoint and linked experimental in vivo data and computer modelling. (
  • Calcium phosphate graphene (CaPG) intrinsically induces osteogenesis in vitro and in the presence of bone marrow stromal cells (BMSCs), can induce ectopic bone formation in vivo. (
  • In vivo results allow us to consider this scaffold as a promising biomaterial to be applied in bone tissue engineering. (
  • Human and pig AMSCs were compared for proliferation/differentiation kinetics and bone neoformation in vivo. (
  • We combined expertise from bone biology and immunology to develop a platform including in vitro osteoclast (OC) and osteoblast (OB) assays and in vivo mouse models of bone repair, immunogenicity, and allergenicity. (
  • Here, we illustrate biocompatibility testing of these biomaterials using primary osteoblast (OB) and osteoclast (OC) assays, an in vivo model of bone repair, an immunological assessment comprising in vitro T lymphocyte proliferation and cytokine production, and in vivo immunogenicity and allergenicity, as previously reported 13 . (
  • PSCs can be isolated by FACS (fluorescence activated cell sorting) from adipose tissue procured during standard liposuction procedures, then combined with an osteoinductive scaffold to achieve bone formation in vivo . (
  • It is concluded that the bone-promoting effects of Sr in vivo are mediated by a reduction in catabolic and osteoblast-osteoclast coupling processes. (
  • Human bone marrow mesenchymal stromal cells (BMSCs) and rabbit implant models were used to test the bioactivity of the microspheres in vitro and in vivo, respectively. (
  • One of the limitations in assessing successful bone regeneration in vivo is the lack of noninvasive high resolution bone quantification methods that allow for multi-modal evaluation of the tissue engineered construct. (
  • Here, we observed high expression of WISP-1 among human PSC in vivo , after purification, and upon transplantation in a bone defect. (
  • clinicians by developing a finite element (FE) numerical model under Comsol Multiphysics simulating the ultrasound stimulation of a human bone in a configuration close to the in-vivo configuration. (
  • In vivo, anisotropic scaffolds demonstrated better bone regeneration capabilities in a rat femoral critical-size defect model by increasing the defect bridging. (
  • Studies selected were original articles publishing results on the effect of different peptides on osteoblasts and osteoprogenitor cells as well as in vivo studies on bone healing. (
  • However, the biological activity of the soluble factors that promote bone formation in vivo is limited by diffusion and degradation, leading to a short half-life. (
  • Micro-CT-based analysis and histological observation revealed that addition of NAC to a collagenous sponge implanted in a critical size cortical bone defect (3.0 mm × 5.0 mm) in rat femur yielded acceleration and completion of defect closure, with thick, compact, and contiguous bone after 6 weeks of healing. (
  • The bone regeneration and healing effect of formononetin was evaluated in a cortical bone defect model that predominantly heals by intramembranous ossification. (
  • The Khoury technique of fixation of the lamina cortical bone and the rationale behind the selection of grafting materials used was clearly explained, with beautiful supporting photographic documentation. (
  • A particulate allograft that consists of cortical bone matrix, and may be used in a variety of reconstructive, periodontal, and oral maxillofacial procedures. (
  • Thanks to these investigation ways, the aim is to assess LCN permeability of the cortical bone which will feed the digital model. (
  • In order to increase the efficiency of the delivered BMPs, we designed cryostructured collagen scaffolds functionalized with hydroxyapatite, mimicking the structure of cortical bone (aligned porosity, anisotropic) or trabecular bone (random distributed porosity, isotropic). (
  • Mr. Papastavrou adds that metal orthopedic implants could be replaced with bone scaffolds in materials that can be broken down by the body. (
  • At present, guided bone regeneration is predominantly applied in the oral cavity to support new hard tissue growth on an alveolar ridge to allow stable placement of dental implants. (
  • Often, when a patient loses teeth due to trauma or disease, bone loss ensues that makes it difficult or impossible to use dentures or dental implants. (
  • To combat this problem, bone grafting, a surgical procedure that replaces bone, is often used to serve as a support for dental implants and replacement teeth. (
  • Allografts therefore lack living cells that could help the implants better integrate with existing bone. (
  • Guided bone regeneration (GBR) is a technique used in dentistry to rebuild part of the bone in the jaw, if necessary, before performing implants and fitting other dental appliances. (
  • Guided bone regeneration may be necessary before dental implants can be installed. (
  • Strong, biodegradable, and intrinsically osteoinductive implants have the capacity to revolutionize the treatment of severe bone injuries. (
  • Volume of the new bone formed after a GBR procedure [ Time Frame: Volume of the new bone formed after the GBR procedure will be determined 6-7 months after the GBR procedure and before the insertion of dental implants. (
  • Bone quality [ Time Frame: Bone quality will be assesed through histological analysis that will be carried out at the time of implants insertion 7-8 months after the GBR procedure. (
  • Patients answering the inclusion but not the exclusion criteria will go through an alveolar computerized tomography (C.T) done routinely before inserting dental implants.At the day of Dental implantation - residual bone left from the site of implantation (after preparing the site with a trephine bur) will be taken to a histological analysis. (
  • The recent past has witnessed a tremendous advancement in the area of orthopaedic surgery and development of bone implants considering the growing number of cases of traumatic injury, tumors, deformity, degeneration and an age related ailments. (
  • The diode laser can also be used for bone regeneration around implants and natural teeth. (
  • The implants can then be applied locally to damaged bone to aid its regeneration. (
  • I confess to having a particular interest in periodontal treatment, implants, and bone grafting. (
  • Boustani, a periodontist, specializes in the care and prevention of gum-related diseases, guided bone regeneration and dental implants. (
  • The placement of dental implants is based on the creation of optimal conditions in the remnant bone. (
  • Bone insufficiency remains a major challenge for bone-anchored implants. (
  • Currently metallic implants are most commonly used, but due to being a much stiffer material than human bones, the implants causes osteoporosis and eventual loosening of the implant. (
  • As a system provider in the implant dentistry sector, BEGO Implant Systems establishes surgical concepts and systematically assembled biomaterial product programs for therapeutic procedures in guided bone and tissue regeneration in addition to implants and a diverse range of prosthetic restoration options. (
  • In laboratory tests, researchers at the Medical College of Georgia applied a protein onto implants that directs endogenous stem cells to become bone-forming cells. (
  • IL-17A accelerates bone formation by stimulating the proliferation and osteoblastic differentiation of mesenchymal progenitor cells. (
  • Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers. (
  • Here, we present a degradable, graphene-based material that mimics the chemical and mechanical composition of bone, promotes differentiation of stem cells, and leads to the formation of new bone in an animal model. (
  • Here, we demonstrate that functional graphenic materials (FGMs) could serve as an osteoinductive scaffold: recruiting native cells to the site of injury and promoting differentiation into bone cells. (
  • Iron-phosphate glass fiber scaffolds for the hard-soft interface regeneration: the effect of fiber diameter and flow culture condition on cell survival and differentiation. (
  • These results indicate that NAC can function as an osteogenesis-enhancing molecule to accelerate bone regeneration by activating differentiation of osteogenic lineages. (
  • 4 . A process according to claim 1 , characterized in that the tissue is one of a type wherein cell proliferation and differentiation is initiated through bio-mechanical transmission of stimuli onto the cytoscleleton and growth or regeneration of tissue can be attained. (
  • 6 . The process according to claim 5 , further comprising the step of initiating and attaining cell proliferation and differentiation through biomechanical transmission of stimuli onto the cytoskeleton and growth or regeneration of tissue. (
  • Synthetic three-dimensional scaffolds for application to the regeneration of bone tissue should present an architecture similar to bone extracellular matrix and provide a suitable microenvironment for cell adhesion, proliferation and differentiation, ensuring tissue growth [1][2]. (
  • Expansion/differentiation/bone neoformation was significantly improved with differentiated pig AMSCs compared with human cells. (
  • The peripheral nervous system is critically involved in bone metabolism, osteogenic differentiation of precursor cells, bone mineralization, and bone remodeling 1 . (
  • Those factors that promote the differentiation of PSC into bone or fat cell types are not well understood. (
  • In the 1980s, demand for artificial bone skyrocketed due to the development of artificial bones made of hydroxyapatite (hydroxylated calcium phosphate), a material similar to natural bone, and those made of tricalcium phosphate, a material that can be resorbed and replaced by natural tissue. (
  • Specifically, bone tissue is formed through the secretion of collagen by osteoblasts and the deposition of hydroxyapatite on the surface of bones. (
  • The nano-level alignment of hydroxyapatite along collagen fibers allows a single material to have tensile and compressive strengths similar to those of natural bone. (
  • Dr Bolzoni says bones are composed of hydroxyapatite and therefore are responsive to electrical stimuli. (
  • Herein, based on our injectable biomimetic hydrogels composed of silk nanofibers (SNF) and hydroxyapatite nanoparticles (HA), deferoxamine (DFO) and bone morphogenetic protein-2 (BMP-2) were loaded on SNF and HA to introduce more angiogenic and osteogenic cues. (
  • One may optionally provide the scaffold with bone tissue forming cells and then deliver a perfusion fluid including oxygen and one or more nutrients through the collagen/hydroxyapatite composite scaffold and to the bone tissue forming cells at a flow rate such that the bone tissue forming cells remodel the collagen/hydroxyapatite composite scaffold and form a bone tissue extracellular matrix. (
  • Several materials, including hydroxyapatite, tricalcium phosphate, demineralised bone matrices, poly-lactic acid homo- and heterodimers, and collagen have been tested as carriers and delivery systems for these factors in a sustained and appropriate manner. (
  • New Rochelle, NY, Feb.15, 2017 -- The range of biomimetic approaches to promote bone growth that are at the core of current bone healing therapies need to more closely emulate natural regenerative mechanisms. (
  • In the recent times, the global market for Global bone regeneration material market research report 2017 has surfaced as one of the most promising markets in the pharmaceutical industry, thanks to the significant rise in research and development activities by leading vendors of Global bone regeneration material market research report 2017 across the world. (
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  • The research report on the Global bone regeneration material market research report 2017 is an analytical study which comprehensively analyzes the competitive framework of this market. (
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  • The study begins with a detailed overview of the market for Global bone regeneration material market research report 2017, including the definition, classification, and industry chain structure of Global bone regeneration material market research report 2017, and move forward to cover every aspect of this market, counting several criteria based on which the market is classified. (
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  • With all these analyses and information, this report can act as a valuable guide to readers looking to gain a clear understanding of all the factors that are influencing the market for Global bone regeneration material market research report 2017 at present and are projected to remain doing so over the forecast period. (
  • Patients who undergo cancer treatment or who experience a major fracture face losing a large volume of bone tissue. (
  • Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. (
  • Here we show that γδ T cells produce IL-17A, which promotes bone formation and facilitates bone fracture healing. (
  • However, bone regeneration potential is limited to the size of the bone fracture 1 , 3 . (
  • Our current understanding of physiological bone healing and healing in the context of biomaterials depends on multiple factors such as mechanical properties and multiple local and systemic factors including cells from the circulation and fracture site 7 , 8 , 9 . (
  • Experimental studies have also provided accumulating evidences that peripheral nerve fibers not only are important in normal bone homeostasis and skeletal growth 3 , but also have influence on repair mechanism of bone fracture 4 . (
  • Bone regeneration does not include callus formed after bone fracture but not yet replaced by hard bone. (
  • The causes of a bone fracture can be very different in nature: trauma, stress (fatigue fracture), idiopathic or congenital bone diseases and disorders, bone metastases, therapeutic treatments such as prostheses implant, bone lengthening or tumor resection. (
  • Although the field of bone regeneration has made great advances in recent decades, coupling personalized diagnosis and optimal treatment of bone fracture remains a challenge due to the large number of variables to be taken into account. (
  • To optimize bone regeneration, Pobloth and colleagues modified titanium-mesh scaffold designs to provide specific strains and stresses within the fracture environment. (
  • When Bone grafting is used in conjunction with sound surgical technique, guided bone regeneration is a reliable and validated procedure. (
  • New bone will fill in the hole in the jaw over time, and the dentist can perform the next step in an implant procedure. (
  • Guided bone regeneration (GBR) is a procedure that has been used in dental surgery for over 20 years for the treatment of bone loss. (
  • GBR is used to re-establish sufficient bone in the alveolar ridge prior to the dental implant procedure. (
  • Previous research had only been able to say that new bone has begun to form within 4-8 weeks of the procedure. (
  • Bone volume obtained following a GBR procedure will be detemined through a comparison of a 3 dimensional analysis of computed tomography images done before and after the GBR procedure. (
  • The researchers mimicked the human surgical procedure in rats, but in addition, they injected - between the fused spinal bones - human stem cells with WISP-1 turned on. (
  • This procedure yields favorable results for bone formation, implant placement, and patient satisfaction. (
  • The selection of a simultaneous or staged approach for the bone grafting procedure is also explained. (
  • It is used in any oral bone regeneration procedure. (
  • Additionally, an FGM can be made by noncovalently loading GO with the growth factor recombinant human bone morphogenetic protein 2 (rhBMP-2), producing a scaffold that induces ectopic bone formation with or without BMSCs. (
  • A study describing the composition of the scaffold and comparing different delivery methods for recombinant human bone morphogenetic protein 2 (rhBMP-2) is published in Tissue Engineering, Part A, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. (
  • Clinicians have traditionally used a growth factor called bone morphogenetic protein 2, or BMP-2, to stimulate bone regrowth in patients. (
  • In the treatment of bone non-unions, an alternative to bone autografts is the use of bone morphogenetic proteins (BMPs), e.g. (
  • The most promising attempts to achieve bone regeneration artificially are based on the application of mediators such as bone morphogenetic proteins (BMPs) directly to the deficient tissue site. (
  • MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay indicated that PGFS were non-cytotoxic against bone marrow stromal cells (bMSCs) after culture for up to 72 h. (
  • Synthetic bone substitutes can be used to replace the lost material, but making these tough enough for the job can be a challenge. (
  • Xenografts are, probably, the most commonly used bone substitutes as seen by the group of Scarano et al. (
  • The results from the C.T and the histological examination will be analyzed for bone quantity (volume) and quality and will allow a comparison of bone characteristics obtained by using different routinely used bone substitutes. (
  • Osteogenesis originates from mesenchymal stem cells (MSCs) differentiating into mature osteoblasts and each period of bone formation is inseparable from the delicate regulation of various miRNAs. (
  • Use of GMP-grade adult human mesenchymal stem cells (MSC) from bone marrow and cancellous bone for musculoskeletal tissue regeneration. (
  • Pig adipose mesenchymal stem cells (AMSCs) could be proposed for the improvement of bone substitute. (
  • Human perivascular stem cells (PSCs) are a novel stem cell class for skeletal tissue regeneration similar to mesenchymal stem cells (MSCs). (
  • The potential and value of stem cell-based therapies were explored in the early 1990s when therapeutically relevant tissue-supportive cells such as mesenchymal stem cells (MSCs) were applied for the regeneration of skeletal tissue. (
  • these values will increase by 2020 to 12 million cases of osteoporosis and over 52 million cases of low bone mass. 1 Focusing only on knee replacement surgery the number of surgical interventions by 2030 is expected to jump nearly to 3.5 million surgeries per year. (
  • 3D printing can now help human bone that has undergone major tissue damage to regenerate, according to research presented on January 19, 2016, at the "Printing for the Future" conference, which took place at the Institute of Physics in London, UK. (
  • New Georgia Tech research points to better ways to heal and regenerate bones using microcomputed tomography (micro-CT) imaging - a process 1 million times more detailed than a traditional CT scan. (
  • However techniques were less predictable when attempting to regenerate lost alveolar (tooth supporting bone) and the adjacent periodontal ligament. (
  • Fish have the extraordinary ability to regenerate lost fins and other appendages containing cartilage and bone. (
  • However, if a bone is lost or damaged due to a disease or an injury, it is difficult for the body to regenerate it. (
  • Studies funded by past DOD awards proved the scaffold's versatility and ability to regenerate large, missing segments of bone. (
  • The separation of the rapidly proliferating soft tissue from the more slowly regenerating hard tissue creates a protected compartment into which cells migrate from the bone defect region and where new bone tissue can regenerate (TAL et al. (
  • Researchers have designed a 3D-printed porous scaffold for use in reconstructing ruptured anterior cruciate ligament in the knee and engineered it to deliver a human bone-promoting protein over an extended period of time to improve bone regeneration. (
  • These results suggest that PGFS could be promising scaffolds for bone regeneration applications. (
  • The results showed that in both groups treated with stem cells, the rate of new bone formation was faster than in the control group, by approximately 2.8 and 4 times in group 2 and 3, respectively. (
  • Importantly, the researchers found that new bone formation was already detectable at two weeks in rats treated with stem cells. (
  • Furthermore, the finding hinted at the mechanism by which the stem cells enhance bone regeneration. (
  • It was not known whether bone-marrow derived stem cells directly mature into osteoblasts - the cells that synthesize bone - or whether they have indirect stimulatory effects on other types of stem cell. (
  • As the process by which osteoblasts form from stem cells takes approximately 14 days, and is known to result in the formation of new tissue by this time, the researchers say the evidence gained by micro-CT supports the idea that the stem cells directly contribute to bone regeneration. (
  • Pictured Left: Schematic model of strategies that combine stem cell technology and gene therapy to tissue engineer bone as described in (Corsi et al. (
  • The Food and Drug Administration (FDA) has warned Parcell Laboratories that it mischaracterized its stem cell-based bone regeneration product as a human cell, tissue and cellular or tissue-based product, when the product is actually a drug or a biologic and must conform to applicable regulations. (
  • The aim of this project is to identify new and minimally-invasive tissue sources of stem cells for bone regeneration. (
  • However, traditional sources of stem cells such as bone marrow are also invasive to harvest and may not always yield high quality stem cells especially in older patients. (
  • Thus, dental tissue may provide a less-invasive alternative to bone marrow as a source of stem cells for bone regeneration. (
  • This encourages the stem cells and growth factor to interact and start growing bone tissue on the scaffold at an accelerated rate. (
  • It also attracts stem cells into the site and promotes a more natural osteoclastic remodelling of biomaterials similar to normal physiological bone turnover. (
  • MAXIBONE aims to create personalised bone regeneration by using culture-expanded autologous bone marrow stem cells and biomaterials. (
  • If only one type is desired for regeneration, then steering the stem cells into creating only that type for a while is effectively the same thing as speeding up their activity in general. (
  • Previous studies showed that a particular type of stem cell - perivascular stem cells - had the ability to become either bone or fat, and that the protein WISP-1 plays a key role in directing these stem cells. (
  • The team then engineered human fat tissue stem cells to make more WISP-1 protein than normal, and found that three genes controlling bone formation became twice as active as in the control cells, and fat driving genes such as peroxisome proliferator-activated receptor gamma (PPARγ) decreased in activity in favor of "bone genes" by 42 percent. (
  • They also observed new bone forming, successfully fusing the vertebrae together, whereas the rats not treated with stem cells making WISP-1 did not show any successful bone fusion during the time the researchers were observing. (
  • One pathway resets existing bone cells to a developmental stem cell-like state and then supports their growth to replace lost cells. (
  • The experiments helped researchers narrow down possible treatments to the use of proteins that directed stem cells to become bone-forming cells. (
  • They found that the combination of the two proteins increased bone formation while inhibiting the formation of fat cells - a negative side effect of BMP2, which encourages stem cells to form both bone and fat cells. (
  • By contrast, NELL-1 encourages stem cells to form bone cells instead of fat cells. (
  • The study showed that NELL-1 works by activating the cellular signaling pathway that regulates whether a stem cell differentiates into a bone cell or a fat cell. (
  • described that osseous regeneration by GBR depends on the migration of pluripotential and osteogenic cells (e.g., osteoblasts derived from the periosteum and/or adjacent bone and/or bone marrow) to the bone defect site and exclusion of cells impeding bone formation (e.g., epithelial cells and fibroblasts) [ 3 ]. (
  • Researchers at Tokyo Institute of Technology (Tokyo Tech) have found a dormant progenitor cell population in zebrafish that regenerates bone cells, or osteoblasts. (
  • How osteoblasts are supplied during bone regeneration has been controversial among bone researchers. (
  • Bone turnover was assessed indirectly by evaluating cellular parameters of PTH action (i.e. numbers of osteoblasts, osteoclasts, apoptotic osteoblasts). (
  • Ob.S/BS Periosteal: Percent periosteal bone perimeter with osteoid and adjacent osteoblasts, identified as plump cells with a single, eccentric nucleus and a pale-staining golgi apparatus. (
  • The prevailing view, based mainly upon in vitro data, is that the beneficial effects of Sr are exerted by the stimulation of bone-forming cells (osteoblasts) and the inhibition of bone-resorbing cells (osteoclasts). (
  • Yang L, Tsang KY, Tang HC et al (2014) Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation. (
  • These bone lesions often require treatment to promote healthy physiological bone repair and regeneration. (
  • As the inflammatory reaction recedes, the stage of tissue repair and regeneration follows. (
  • Bone regeneration often requires cues from osteogenesis-inducing factors for successful outcome. (
  • To investigate the effects of inferior alveolar nerve on new bone formation in rabbit mandibular distraction osteogenesis. (
  • The loss of the sensory nerves could result in a decrease of the new bone quality during the mandibular distraction osteogenesis. (
  • However, it remains unclear whether the peripheral nerve ingrowth is crucial to the new bone formation in the scenario of endogenous or exogenous bone regeneration, such as distraction osteogenesis and bone tissue engineering respectively. (
  • Bone regeneration is a complex process in which angiogenesis and osteogenesis are crucial. (
  • The angiogenesis and osteogenesis outcomes accelerated the regeneration of vascularized bones toward similar composition and structure to natural bones. (
  • MicroRNAs (miRNAs) are endogenous small noncoding ~22-nt RNAs, which have been reported to play a crucial role in maintaining bone development and metabolism. (
  • In a murine model of hepatitis B, authors examined whether this pathway of regeneration is enhanced by inhibiting endogenous hepatocyte regeneration. (
  • BMCs contribute to the regeneration of the chronically damaged liver particularly under conditions where endogenous hepatocyte replication is blocked. (
  • Our study supports the hypothesis that endogenous bone defect regeneration can be promoted by mechanobiologically optimized Ti-mesh scaffolds. (
  • Dr. Manitha B. Nair, Dr. Deepthy Menon, and Shantikumar V. Nair, "Porous Composite Fibrous Scaffold for Bone Tissue Regeneration", U.S. Patent 15/341,866 2016. (
  • Last year, as summer turned to autumn, I received an email from Trycare: an invitation to a bone regeneration course in December 2016. (
  • Goldring SR, Goldring MB (2016) Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone cross talk. (
  • In this report, the global Bone Regeneration Material market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022. (
  • Their yield stress and modulus were ~0.38 and ~2.84 MPa, respectively, with the strength being higher than the lower bound of the compressive strength of cancellous bone. (
  • Bacterin OsteoSponge block is a novel, cancellous demineralized bone matrix from curasan. (
  • Bone turnover was assessed indirectly by bone histomorphometry using the following abbreviations: Mineral Apposition Rate (MAR): Distance between 2 fluorochrome markers that comprise a double label on the surfaces of cancellous bone measured at an average of 4 equally-spaced sites per double label. (
  • Oc.S/BS cancellous: Osteoclast suface divided by bone surface. (
  • Osteoclastic surface as percent of total bone surface in cancellous bone. (
  • Percent cancellous bone perimeter with osteoclasts (large, multinuclear, TRAP positive cells). (
  • OS/BS cancellous: Osteoid surface divided by bone surface. (
  • Percentage of cancellous bone perimeter covered with osteoid. (
  • Bones are always regenerating through a perpetual cycle of bone resorption and bone formation. (
  • Major side effects of this strategy are derived from the supraphysiological doses of BMPs needed, which may induce ectopic bone formation, chronic inflammation, and excessive bone resorption. (
  • Galactosyl-knock-out engineered pig as a xenogenic donor source of adipose MSCs for bone regeneration. (
  • We purposefully modified MSCs to facilitate bone healing in inflammatory scenarios: by preconditioning the MSCs, and by genetically modifying MSCs to first sense NFκB activation and then overexpress the anti-inflammatory pro-regenerative cytokine IL-4. (
  • Application of the gelatin hydrogel-CCN2 complex, together with a collagen scaffold to the bone defect prepared in a rat femur resulted in remarkable induction of osteoblastic mineralization markers within 2 weeks. (
  • Despite their potential, decades of research have failed to generate a synthetic material that incorporates all of the necessary characteristics of an ideal bone scaffold and cultivates an optimal environment for bone regeneration. (
  • Dr Leandro Bolzoni from the University of Waikato's School of Engineering has been awarded a Health Research Council explorer grant worth $150,000 to research bone regeneration using alternative synthetic materials for joint replacements. (
  • Oral and intravenous medications affect the whole body, but to promote joint regeneration in a particular joint, two potent options are intra-articular steroid injection and synovectomy. (
  • CCN family protein 2/connective tissue growth factor (CCN2/CTGF) is a unique molecule that promotes the entire endochondral ossification process and regeneration of damaged articular cartilage. (
  • Liu Y, Lian Q, He J et al (2011) Study on the microstructure of human articular cartilage/bone Interface. (
  • The following therapies do not rely on autologous cells: A vibration technique developed by Ellen L. Barnard and Myrtile Wilhite claims to promote regeneration in the vaginal cell lining. (
  • 3] Brunel G, Brocard D, Duffort JF, Jacquet E, Justumus P, Simonet T, Benque E: Bioabsorbable materials for guided bone regeneration prior to implant placement and 7-year followup: report of 14 cases. (
  • Therefore, further characterization of polyphosphate function may be pertinent to the regulation of pathological mineralization as well as the promotion of bone regeneration. (
  • Finally, distinct enhancement of bone regeneration was observed 3 weeks after the application of the complex. (
  • In situations where strong inhibition of synovitis combined with self-regeneration cannot repair severe joint destruction, regenerative medicine may in the future play a crucial role in the regeneration of damaged joints. (
  • This book concentrates on such procedures that may well be counted among the recent outstanding breakthroughs in bone regenerative therapy. (
  • This is due to our cortical bones' regenerative capability. (
  • With this, the technology of bone regenerative medicine finally advanced. (
  • The feasibility and bone-regenerative capacity of intraoperative constructs were determined histologically and histomorphometrically in a rat femoral condyle bone defect model. (
  • In conclusion, we here demonstrate the feasibility of intraoperative SVF construct preparation and superior bone-regenerative capacity thereof compared to donor-matched ADMSC constructs. (
  • Infection is a dreaded complication of traumatic bone injury, and the ability to incorporate antibiotics into the NuCress™ scaffold offers the tremendous added benefit of preventing infection in a contaminated bone defect without compromising its bone regenerative properties," Smeltzer said. (
  • Some organizations which perform research into, or conduct regeneration procedures, include the Wake Forest Institute for Regenerative Medicine, the United States Department of Defense, and the California Institute for Regenerative Medicine. (
  • Guided bone regeneration procedures typically require follow-up X-rays to monitor progress. (
  • Used in guided bone and guided tissue regeneration procedures, the GUIDOR Bioresorbable Matrix Barrier is made of a homogenous blend of compounds that have been used in the food and medical industries for more than 2 decades (check out these FAQs to learn more). (
  • Currently, autograft and allograft bone transplantation is the approach of choice 4 with 2.2 million bone replacement procedures annually 5 . (
  • Although various forms of materials were developed, such as solid blocks, powder, and pumice-like materials, problems persisted as these materials were difficult to be used in surgical procedures and sometimes got completely absorbed after transplant without leading to bone regeneration. (
  • A shapeable, ossifying scaffold for the growth of natural bone in periodontal and implant procedures. (
  • It provides prolonged barrier function in a wide range of guided bone and tissue regeneration procedures. (
  • The U.S. Food and Drug Administration allows for the use of recombinant BMP to encourage bone-growth following some surgical procedures. (
  • 1 . Zubery Y, Goldlust A, Alves A, Nir E. Ossification of a novel cross-linked porcine collagen barrier in guided bone regeneration in dogs. (
  • These results are quite promising because they can allow for the production of bioactive and biodegradable 3D porous scaffolds to be used in bone tissue engineering applications. (
  • Bioactive glass is more reactive than these materials, and promotes bone regeneration by releasing silica ions. (
  • Guldberg and his collaborators at the University of Rochester , for example, have explored various strategies to revitalize dead allograft bone. (
  • The scans of the healing allograft (left) are segmented to separate the allograft bone (middle) from the new bone that formed (right) as described in (Koefoed et al. (
  • NELL-1, when given systemically, does not appear to induce ectopic bone. (
  • This study identifies a novel role for IL-17-producing γδ T cells in skeletal tissue regeneration. (
  • The selection of an appropriate grafting material is one of the factors that is important in achieving adequate bone formation following bone regeneration grafting. (
  • There are several modalities of bone regeneration including tissue engineering, guided bone regeneration, distraction ontogenesis, and bone grafting. (
  • Bone grafting in particular seems almost like science fiction to me. (
  • The present disclosure is directed at a process to form bone grafting material. (
  • Dr. Ting and his research team have made a very valuable discovery for the field of bone regeneration," said Dr. No-Hee Park, dean of the UCLA School of Dentistry. (
  • Manipulating the growth of crystals in a 3D-printed material makes it possible to improve the microstructures of bone scaffolds. (
  • In addition to studying bone regeneration, the ability to look at detailed 3-D images of vascular networks can shed light on research into vascular injuries, disc degeneration in the back and help detect tumors early by pinpointing areas of increased vascularization (which often indicate tumor growth). (
  • The process of guided bone regeneration can be monitored with periodic physical exams and X-rays to check on bone growth. (
  • Platelet-rich fibrin is a bioscaffold and reservoir of growth factors for tissue regeneration," Tissue Engineering A , vol. 17, no. 3-4, pp. 349-359, 2011. (
  • These barriers stop the growth of gum tissue cells and allows regeneration of new periodontal ligament by guiding cell growth. (
  • Our team of biomedical engineers from the Centre for the Cellular Microenvironment have discovered that a cheap commercially produced polymer helps to stimulate molecules that aid bone growth. (
  • Growth factors are produced by cells to tell other cells nearby what to do, and they play an important role in the development of bone and cartilage. (
  • The NuCress™ scaffold is a game-changing technology that will revolutionize treatment of bone diseases because it is capable of simultaneously promoting bone regeneration and delivering antibiotics, growth factors, and cell-based therapies," Anderson said. (
  • But the high concentrations needed to induce human bone formation may have serious side effects, including life-threatening cervical swelling and abnormal and inconsistent bone growth. (
  • The same research team has conducted other studies on bone growth, including one that utilized a protein called NELL-1, which successfully increased bone formation and stimulated key factors for bone growth in multiple preclinical models. (
  • It also showed that BMP2 can induce non-bone cells to form bone, with the potential risk for ectopic bone growth - bone formation in undesirable locations. (
  • In contrast to BMP2, the novel ability of NELL-1 to stimulate bone growth and repress the formation of fat may highlight new treatment approaches for osteoporosis and other therapies for bone loss," Soo said. (
  • These models were followed by the development of bioregulatory models where mechanics was neglected and regeneration was regulated only by biological stimuli such as growth factors. (
  • An ideal treatment consists of a scaffold that promotes regeneration, matches the chemical and mechanical properties of bone, and degrades with a timeline matching the healing process. (
  • Traumatic bone injuries or deformities are among the most common conditions that require surgical intervention affecting patients in the United States today. (
  • May 2012 Barnard, E. and Wilhite M. Patent application number: 20120136287 "Regeneration of Vaginal Tissue with non-systemic vaginal administration of Estrogen" May 2009 Lyle, J. Patent application number: 20090124584 "Surgical Techniques: Reconstructive Surgery of the Clitoris after Ritual Excision. (
  • Various concentrations of NAC (0, 2.5, 5.0, and 10 mM) were added to rat bone marrow stromal cell or osteoblastic cell culture in media with or without dexamethasone. (
  • Moreover, antibodies against sclerostin have been evaluated in a bone defect model in diabetic rats and showed superior effects compared to the osteo-anabolic hormone PTH. (
  • The rat calvarial bone defect model has been well-performed in previous studies by our group (e.g. 3863, 4903, 6483, 6866, 12936). (
  • A conceptually new type of bio-hybrid scaffold for bone regeneration. (
  • Tissue engineers can choose from a wide range of living cells, biomaterials and proteins to repair a bone defect. (
  • The focus of the research area Bone and Tissue Regeneration is to define the molecular and cellular mechanisms of bone regeneration as well as the interactions of immune and cancer cells within bone regeneration. (
  • Understanding of osteocyte biology, as these cells and their products (sclerostin, FGF-23) are increasingly recognized to play a central regulatory role of bone and mineral homeostasis. (
  • 10 . The process according to claim 5 , characterised in that the means ( 16 ) for the biological anchoring of bone cells incorporates protein molecules and/or interconnecting pores. (
  • According to Atsushi Kawakami, an Associate Professor who specializes in tissue regeneration and led the study, scientists disagree on how these cells are made. (
  • In conclusion, the findings suggest that a lineage of bone-producing cell, which are specified in embryonic somites, are maintained throughout the animal lives as progenitor cells for bone regeneration and also for bone maintenance (Figure 3). (
  • Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney. (
  • Bone marrow cells (BMCs) can differentiate across lineages to repair injured organs, including the kidney. (
  • However, the relative contribution of intrarenal cells and extrarenal cells to kidney regeneration is not clear. (
  • Bone regeneration is made possible by the interaction between two kinds of cells: osteoblast and osteoclast. (
  • Osteoblast, on the other hand, is a small cell with a diameter of about 10 μm, and it forms new bones by working with many other cells. (
  • By taking advantage of the characteristics of the two components, we were able to create a material that is functionally identical to natural bone that bone cells can easy adhere to. (
  • The histological investigation showed that the bone trabeculae were dis-arrayed containing dispersed cartilage cells on the denervation side, whereas the bone trabeculae were orderly with rich blood vessels and no cartilage cell on the control side. (
  • They have superior properties for the stimulation of bone formation and bone bonding, both related to the specific interactions of their surface with the extracellular fluids and cells, ie, ionic exchanges, superficial molecular rearrangement and cellular activity. (
  • Researchers here do this for cells that create both fat and bone tissue, identifying a regulatory protein, WISP1 , that determines which is produced. (
  • These cells can then be harvested, engineered to express a higher level of WISP1 , and used as a cell therapy to accelerate bone regrowth. (
  • The second directs the newly formed cells to turn back into functional, organized bone. (
  • We focused on the bones of the zebra fish tail fin," Stankunas said, "and asked how amputation induces mature bone-lining cells to go backwards in their developmental age to what's called a progenitor state. (
  • The researchers found that cell-to-cell signaling mediated by the Wnt pathway helps existing mature bone cells become progenitor cells after fin amputation. (
  • Local Wnt production at the tip of the regrowing fin then maintains a pool of dividing bone progenitor cells until the fin is fully replaced. (
  • The job of second pathway, BMP, is to convert the progenitor cells back into mature bone that forms the characteristic bony rays of a fish's fins. (
  • Around teeth, the bone-forming cells grew into existing bone and eventually morphed into bone themselves. (
  • The two proteins complement each other in that BMP2 helps to turn non-bone cells into bone-forming cells, and NELL-1 then increases the bone-forming ability of bone cells. (
  • P olyphosphates are inorganic chains of phosphates that naturally occur in many cells types and that are present at higher concentrations in bone cells. (
  • Estimation of the mechanical effects induced by ultrasound (US) on bone cells - This part of the study concerns 2 scales and several physics using an FE model (Comsol Multiphysics). (
  • A biomaterial scaffold was used as a template to analyse the behaviour of the pre-osteoblastic bone cells to produce new bone-like tissue. (
  • Bone marrow cells (BMCs) can contribute to regeneration of the chronically damaged liver, but in human studies and animal models the magnitude of this axis is highly variable. (
  • Proliferation of small hepatocyte like progenitor cells, appearing at 6 months, may suggest that in the presence of refrorsine these cells compromise bone marrow cell engraftment in the mouse. (
  • Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study. (
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