Bone Regeneration: Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.Regeneration: The physiological renewal, repair, or replacement of tissue.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Guided Tissue Regeneration: Procedures for enhancing and directing tissue repair and renewal processes, such as BONE REGENERATION; NERVE REGENERATION; etc. They involve surgically implanting growth conducive tracks or conduits (TISSUE SCAFFOLDING) at the damaged site to stimulate and control the location of cell repopulation. The tracks or conduits are made from synthetic and/or natural materials and may include support cells and induction factors for CELL GROWTH PROCESSES; or CELL MIGRATION.Bone Substitutes: Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.Osteogenesis: The process of bone formation. Histogenesis of bone including ossification.Nerve Regeneration: Renewal or physiological repair of damaged nerve tissue.Liver Regeneration: Repair or renewal of hepatic tissue.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Tissue Scaffolds: Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.X-Ray Microtomography: X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.Calcium Phosphates: Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.Bone Morphogenetic Protein 2: A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.Skull: The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Bone Matrix: Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.Bone Diseases: Diseases of BONES.Biocompatible Materials: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.Tissue Engineering: Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.Parietal Bone: One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.Osteoblasts: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.Platelet-Rich Plasma: A preparation consisting of PLATELETS concentrated in a limited volume of PLASMA. This is used in various surgical tissue regeneration procedures where the GROWTH FACTORS in the platelets enhance wound healing and regeneration.Bone Transplantation: The grafting of bone from a donor site to a recipient site.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.Bone Development: The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.Guided Tissue Regeneration, Periodontal: Techniques for enhancing and directing cell growth to repopulate specific parts of the PERIODONTIUM that have been damaged by PERIODONTAL DISEASES; TOOTH DISEASES; or TRAUMA, or to correct TOOTH ABNORMALITIES. Repopulation and repair is achieved by guiding the progenitor cells to reproduce in the desired location by blocking contact with surrounding tissue by use of membranes composed of synthetic or natural material that may include growth inducing factors as well.Absorbable Implants: Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.Bone Resorption: Bone loss due to osteoclastic activity.Implants, Experimental: Artificial substitutes for body parts and materials inserted into organisms during experimental studies.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Mesenchymal Stromal Cells: Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.Fracture Healing: The physiological restoration of bone tissue and function after a fracture. It includes BONY CALLUS formation and normal replacement of bone tissue.Bone Morphogenetic Proteins: Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.Osseointegration: The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).Calcification, Physiologic: Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.Mandible: The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.Femur: The longest and largest bone of the skeleton, it is situated between the hip and the knee.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Osteogenesis, Distraction: Bone lengthening by gradual mechanical distraction. An external fixation device produces the distraction across the bone plate. The technique was originally applied to long bones but in recent years the method has been adapted for use with mandibular implants in maxillofacial surgery.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Wound Healing: Restoration of integrity to traumatized tissue.Periosteum: Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.Porosity: Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.Alveolar Bone Loss: Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.Alkaline Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.Nanofibers: Submicron-sized fibers with diameters typically between 50 and 500 nanometers. The very small dimension of these fibers can generate a high surface area to volume ratio, which makes them potential candidates for various biomedical and other applications.Nanocomposites: Nanometer-scale composite structures composed of organic molecules intimately incorporated with inorganic molecules. (Glossary of Biotechnology and Nanobiotechology Terms, 4th ed)Calcium Sulfate: A calcium salt that is used for a variety of purposes including: building materials, as a desiccant, in dentistry as an impression material, cast, or die, and in medicine for immobilizing casts and as a tablet excipient. It exists in various forms and states of hydration. Plaster of Paris is a mixture of powdered and heat-treated gypsum.Bone Morphogenetic Protein 7: A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.Dental Implants: Biocompatible materials placed into (endosseous) or onto (subperiosteal) the jawbone to support a crown, bridge, or artificial tooth, or to stabilize a diseased tooth.Bone Cements: Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.Hematocele: Hemorrhage into a canal or cavity of the body, such as the space covered by the serous membrane (tunica vaginalis) around the TESTIS leading to testicular hematocele or scrotal hematocele.Maxillary Sinus: The air space located in the body of the MAXILLARY BONE near each cheek. Each maxillary sinus communicates with the middle passage (meatus) of the NASAL CAVITY on the same side.Ceramics: Products made by baking or firing nonmetallic minerals (clay and similar materials). In making dental restorations or parts of restorations the material is fused porcelain. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Boucher's Clinical Dental Terminology, 4th ed)Materials Testing: The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.Skull Fractures: Fractures of the skull which may result from penetrating or nonpenetrating head injuries or rarely BONE DISEASES (see also FRACTURES, SPONTANEOUS). Skull fractures may be classified by location (e.g., SKULL FRACTURE, BASILAR), radiographic appearance (e.g., linear), or based upon cranial integrity (e.g., SKULL FRACTURE, DEPRESSED).Mandibular Injuries: Injuries to the lower jaw bone.Polyglycolic Acid: A biocompatible polymer used as a surgical suture material.Mandibular Osteotomy: Intraoral OSTEOTOMY of the lower jaw usually performed in order to correct MALOCCLUSION.Mandibular Fractures: Fractures of the lower jaw.Bony Callus: The bony deposit formed between and around the broken ends of BONE FRACTURES during normal healing.Gelatin: A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Fractures, Bone: Breaks in bones.Dental Implantation, Endosseous: Insertion of an implant into the bone of the mandible or maxilla. The implant has an exposed head which protrudes through the mucosa and is a prosthodontic abutment.Core Binding Factor Alpha 1 Subunit: A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.Tibia: The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Microscopy, Electron, Scanning: Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.Mesenchymal Stem Cell Transplantation: Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Alveolar Process: The thickest and spongiest part of the maxilla and mandible hollowed out into deep cavities for the teeth.Apatites: A group of phosphate minerals that includes ten mineral species and has the general formula X5(YO4)3Z, where X is usually calcium or lead, Y is phosphorus or arsenic, and Z is chlorine, fluorine, or OH-. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Silk: A continuous protein fiber consisting primarily of FIBROINS. It is synthesized by a variety of INSECTS and ARACHNIDS.Silicone Elastomers: Polymers of silicone that are formed by crosslinking and treatment with amorphous silica to increase strength. They have properties similar to vulcanized natural rubber, in that they stretch under tension, retract rapidly, and fully recover to their original dimensions upon release. They are used in the encapsulation of surgical membranes and implants.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Polyesters: Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.Hydrogels: Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)Mandibular Neoplasms: Tumors or cancer of the MANDIBLE.Tooth Socket: A hollow part of the alveolar process of the MAXILLA or MANDIBLE where each tooth fits and is attached via the periodontal ligament.Chitosan: Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.Ricinus: A plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. The seed of Ricinus communis L. is the CASTOR BEAN which is the source of CASTOR OIL; RICIN; and other lectins.Dental Implantation: The grafting or inserting of a prosthetic device of alloplastic material into the oral tissue beneath the mucosal or periosteal layer or within the bone. Its purpose is to provide support and retention to a partial or complete denture.Osteocytes: Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.Biomimetic Materials: Materials fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems.Nephroblastoma Overexpressed Protein: A CCN protein family member found at high levels in NEPHROBLASTOMA cells. It is found both intracellularly and in the EXTRACELLULAR MATRIX and may play a role in the regulation of CELL PROLIFERATION and EXTRACELLULAR MATRIX synthesis.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Alginates: Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.Membranes, Artificial: Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.Planarians: Nonparasitic free-living flatworms of the class Turbellaria. The most common genera are Dugesia, formerly Planaria, which lives in water, and Bipalium, which lives on land. Geoplana occurs in South America and California.Hepatectomy: Excision of all or part of the liver. (Dorland, 28th ed)Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)Femoral Fractures: Fractures of the femur.Models, Animal: Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.Hydrogel: A network of cross-linked hydrophilic macromolecules used in biomedical applications.Osteocalcin: Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.Siloxanes: Silicon polymers that contain alternate silicon and oxygen atoms in linear or cyclic molecular structures.Alveolar Ridge Augmentation: Preprosthetic surgery involving rib, cartilage, or iliac crest bone grafts, usually autologous, or synthetic implants for rebuilding the alveolar ridge.Bone Diseases, MetabolicGlass: Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.Integrin-Binding Sialoprotein: A highly glycosylated and sulfated phosphoprotein that is found almost exclusively in mineralized connective tissues. It is an extracellular matrix protein that binds to hydroxyapatite through polyglutamic acid sequences and mediates cell attachment through an RGD sequence.Mice, Inbred C57BLPolypropylenes: Propylene or propene polymers. Thermoplastics that can be extruded into fibers, films or solid forms. They are used as a copolymer in plastics, especially polyethylene. The fibers are used for fabrics, filters and surgical sutures.Minerals: Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Ameloblastoma: An immature epithelial tumor of the JAW originating from the epithelial rests of Malassez or from other epithelial remnants of the ENAMEL from the developmental period. It is a slowly growing tumor, usually benign, but displays a marked propensity for invasive growth.Axons: Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.Periodontal Ligament: The fibrous CONNECTIVE TISSUE surrounding the TOOTH ROOT, separating it from and attaching it to the alveolar bone (ALVEOLAR PROCESS).Compressive Strength: The maximum compression a material can withstand without failure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p427)Polytetrafluoroethylene: Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.Neovascularization, Physiologic: The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.Salamandridae: A family of Urodela consisting of 15 living genera and about 42 species and occurring in North America, Europe, Asia, and North Africa.Extremities: The farthest or outermost projections of the body, such as the HAND and FOOT.Coated Materials, Biocompatible: Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Ambystoma mexicanum: A salamander found in Mexican mountain lakes and accounting for about 30 percent of the urodeles used in research. The axolotl remains in larval form throughout its life, a phenomenon known as neoteny.Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Adult Stem Cells: Cells with high proliferative and self renewal capacities derived from adults.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Nerve Crush: Treatment of muscles and nerves under pressure as a result of crush injuries.Prostheses and Implants: Artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.Rats, Nude: A mutant strain of Rattus norvegicus without a thymus and with depressed or absent T-cell function. This strain of rats may have a small amount of hair at times, but then lose it.Multipotent Stem Cells: Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Polyurethanes: A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Smad5 Protein: A receptor-regulated smad protein that undergoes PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS. It regulates BONE MORPHOGENETIC PROTEIN signaling and is essential for PHYSIOLOGICAL ANGIOGENESIS.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed)Notophthalmus viridescens: A species of newt in the Salamandridae family in which the larvae transform into terrestrial eft stage and later into an aquatic adult. They occur from Canada to southern United States. Viridescens refers to the greenish color often found in this species.Temporal Bone: Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).Tooth Extraction: The surgical removal of a tooth. (Dorland, 28th ed)Animal Fins: Membranous appendage of fish and other aquatic organisms used for locomotion or balance.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Anthraquinones: Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.Biomechanical Phenomena: The properties, processes, and behavior of biological systems under the action of mechanical forces.Craniosynostoses: Premature closure of one or more CRANIAL SUTURES. It often results in plagiocephaly. Craniosynostoses that involve multiple sutures are sometimes associated with congenital syndromes such as ACROCEPHALOSYNDACTYLIA; and CRANIOFACIAL DYSOSTOSIS.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.Umbilical Cord: The flexible rope-like structure that connects a developing FETUS to the PLACENTA in mammals. The cord contains blood vessels which carry oxygen and nutrients from the mother to the fetus and waste products away from the fetus.Hexuronic Acids: Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.TailGlucuronic Acid: A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.Rats, Inbred F344Nanostructures: Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Satellite Cells, Skeletal Muscle: Elongated, spindle-shaped, quiescent myoblasts lying in close contact with adult skeletal muscle. They are thought to play a role in muscle repair and regeneration.Surface Properties: Characteristics or attributes of the outer boundaries of objects, including molecules.Fumarates: Compounds based on fumaric acid.Spinal Cord Regeneration: Repair of the damaged neuron function after SPINAL CORD INJURY or SPINAL CORD DISEASES.Sciatic Nerve: A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.Prosthesis Implantation: Surgical insertion of a prosthesis.Elastic Modulus: Numerical expression indicating the measure of stiffness in a material. It is defined by the ratio of stress in a unit area of substance to the resulting deformation (strain). This allows the behavior of a material under load (such as bone) to be calculated.Drug Carriers: Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Injections: Introduction of substances into the body using a needle and syringe.Osteoclasts: A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.Cell Culture Techniques: Methods for maintaining or growing CELLS in vitro.Osteotomy: The surgical cutting of a bone. (Dorland, 28th ed)Vascular Endothelial Growth Factor A: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Bone Cysts: Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.Osteopontin: A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Zebrafish: An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.Drug Implants: Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.Stromal Cells: Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.Axotomy: Transection or severing of an axon. This type of denervation is used often in experimental studies on neuronal physiology and neuronal death or survival, toward an understanding of nervous system disease.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Staining and Labeling: The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.Microspheres: Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.Regenerative Medicine: A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Intercellular Signaling Peptides and Proteins: Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.Peripheral Nerves: The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Schwann Cells: Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.Smad1 Protein: A receptor-regulated smad protein that undergoes PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS. It regulates BONE MORPHOGENETIC PROTEIN signaling and plays an essential role in EMBRYONIC DEVELOPMENT.Extracellular Matrix: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.

Enhancement of osteogenesis in vitro and in vivo by a novel osteoblast differentiation promoting compound, TAK-778. (1/883)

TAK-778 [(2R,4S)-(-)-N-(4-diethoxyphosphorylmethylphenyl)-1,2,4, 5-tetrahydro-4-methyl-7, 8-methylenedioxy-5-oxo-3-benzothiepin-2-carboxyamide; mw 505.53], a novel osteoblast differentiation promoting compound, was characterized in vitro and in vivo models. TAK-778 at doses of 10(-6) M and higher promoted potently bone-like nodule formation in the presence of dexamethasone in rat bone marrow stromal cell culture. This was accompanied by increases in cellular alkaline phosphatase activity, soluble collagen release, and osteocalcin secretion. Under the culture conditions, TAK-778 also stimulated the secretion of transforming growth factor-beta and insulin-like growth factor-I, indicating that TAK-778 may exert regulatory effects on osteoblast differentiation via autocrine/paracrine mechanisms. Furthermore, the in vivo osteogenic potential of TAK-778 was studied in bony defect and osteotomy animal models, using sustained release microcapsules consisted of a biodegradable polymer, poly (dl-lactic/glycolic) acid (PLGA). Single local injection of TAK-778/PLGA-microcapsules (PLGA-MC) (0.2-5 mg/site) to rat skull defects resulted in a dose-dependent increase in new bone area within the defects after 4 weeks. When the pellet containing TAK-778/PLGA-MC (4 mg/pellet) was packed into place to fill the tibial segmental defect in rabbit, this pellet induced osseous union within 2 months, whereas the placebo pellet did not. In addition, single local application of TAK-778/PLGA-MC (10 mg/site) to rabbit tibial osteotomy site enhanced callus formation accompanied by an increase in breaking force after 30 days. These results reveal for the first time that a nonendogenous chemical compound promotes potently osteogenesis in vitro and enhances new bone formation during skeletal regeneration and bone repair in vivo and should be useful for the stimulation of fracture healing.  (+info)

Acceleration of increase in bone mineral content by low-intensity ultrasound energy in leg lengthening. (2/883)

The effect of ultrasound energy on bone has been studied for a long time. In particular, multiple effects of low-intensity ultrasound energy have recently been demonstrated experimentally, such as increases in bending strength of fracture callus, acceleration of soft callus formation and endochondral ossification of the callus at the fracture site, stimulation of aggrecan gene expression, or modulation of TGF-beta synthesis and increase of calcium uptake. Clinically, prospective, randomized, and double-blind trials showed the efficacy of low-intensity ultrasound beam stimulation in the acceleration of fracture healing, with a significant decrease in the time to healing. On the other hand, callotasis, a popular method for bone lengthening, requires much time for new bone formation, and an external fixator must be remain on the patient for a long period. This is one of the major problems of the callotasis technique. If ultrasound energy stimulation could accelerate the rate of callus formation in callotasis, the external fixator could be removed earlier, the treatment period could be shortened, and the patient could return to daily activities more quickly. We report on the use low-intensity ultrasound beam stimulation during leg lengthening with the callotasis method in which callus formation was poor.  (+info)

Bone morphogenetic proteins in human bone regeneration. (3/883)

Recently, the first clinical reports on bone regeneration by two recombinant human bone morphogenetic proteins (rhBMPs), BMP-2 and BMP-7 (also named osteogenic protein-1, OP-1) have been published (1-4). Although both BMPs were able to support bone regeneration, a significant variation in individual response was observed with both proteins. Animal studies and laboratory experiments reveal a number of conditions that influence the osteoinductivity of BMP, such as BMP concentration, carrier properties and influence of local and systemic growth factors and hormones. In this paper, these studies and the clinical reports are reviewed, and the conditions that modulate the BMP-dependent osteoinduction are discussed. The information may provide clues as to how the performance of recombinant human BMP as bone-graft substitute in humans can be improved.  (+info)

Bone marrow stromal cells: characterization and clinical application. (4/883)

The bone marrow stroma consists of a heterogeneous population of cells that provide the structural and physiological support for hematopoietic cells. Additionally, the bone marrow stroma contains cells with a stem-cell-like character that allows them to differentiate into bone, cartilage, adipocytes, and hematopoietic supporting tissues. Several experimental approaches have been used to characterize the development and functional nature of these cells in vivo and their differentiating potential in vitro. In vivo, presumptive osteogenic precursors have been identified by morphologic and immunohistochemical methods. In culture, the stromal cells can be separated from hematopoietic cells by their differential adhesion to tissue culture plastic and their prolonged proliferative potential. In cultures generated from single-cell suspensions of marrow, bone marrow stromal cells grow in colonies, each derived from a single precursor cell termed the colony-forming unit-fibroblast. Culture methods have been developed to expand marrow stromal cells derived from human, mouse, and other species. Under appropriate conditions, these cells are capable of forming new bone after in vivo transplantation. Various methods of cultivation and transplantation conditions have been studied and found to have substantial influence on the transplantation outcome. The finding that bone marrow stromal cells can be manipulated in vitro and subsequently form bone in vivo provides a powerful new model system for studying the basic biology of bone and for generating models for therapeutic strategies aimed at regenerating skeletal elements.  (+info)

Bone wound healing after maxillary molar extraction in ovariectomized aged rats: quantitative backscattered electron image analysis. (5/883)

The processes of bone wound healing after maxillary molar extraction in ovariectomized aged rats were examined by means of quantitative backscattered electron image analysis and energy-dispersive X-ray microanalysis. Six-month-old female rats were either sham-operated or underwent bilateral ovariectomy (OVX), and 60 days postoperatively, the maxillary first molars were extracted. On post-extraction days 7, 30, and 60, the dissected and resin-embedded maxillae were micromilled in the transverse direction through the extracted alveolar sockets, and new bone formation on the buccal maxillary bone surface and within the extracted alveolar sockets was examined. In both sham-operated control and OVX rats, new bone formation was recognized on the buccal bone surface, as well as within the extracted sockets, and increased daily through to day 60. In comparison to sham-operated controls, new bone formation in OVX rats was significantly decreased both on the buccal bone surface and within the extracted sockets. Our results suggest that bone wound healing by new bone formation after maxillary molar extraction is significantly decreased in OVX-induced osteoporosis.  (+info)

Healing of erosions in rheumatoid arthritis. (6/883)

Reports on healing of erosions in rheumatoid arthritis are rare. However, it is expected that repair of erosions should be seen more often during the period of extensive use of disease modifying antirheumatic drugs, especially in patients who experience sustained remission. Two such cases are described.  (+info)

A modular femoral implant for uncemented stem revision in THR. (7/883)

We present the early results of 142 uncemented femoral stem revisions using the modular MRP-Titan system. There were 70 cases with marked preoperative femoral bone defects (Paprosky type 2C and type 3); and bone grafts were used in 31 cases. At a mean follow-up of 2.3 years five cases were re-revised due to dislocation and two due to aseptic loosening. The mean Harris hip score improved from 37.4 preoperatively to 92.4. In 122 cases progressive bone regeneration on X-ray was seen; and no further osteolysis was observed.  (+info)

The Wagner revision prosthesis consistently restores femoral bone structure. (8/883)

The short-term results are reported for 43 hip revision operations with the long-stemmed Wagner prosthesis. The patients were followed-up for an average of 25 months. The Charnley scores were; pain 5.2, movement 4.0 and walking 4.0. All patients except one showed abundant new bone formation. The stem subsided more than 20 mm in 5 patients and in 22 the subsidence was less than 5 mm. The major complication was dislocation, which occurred in 9 patients; 8 of these were reoperated and from then on remained stable.  (+info)

DOI: 10.11607/prd.00.0510 The effect of the pure-phase beta-tricalcium phosphate (beta-TCP) Cerasorb on bone regeneration was evaluated in hollow titanium cylinders implanted in the posterior jaws of five volunteers. Beta-TCP particles were inserted inside the cylinders and harvested 6 months after placement. The density of the newly formed bone inside the bone-growing chambers measured 27.84% 24.67% in test and 17.90% 4.28% in control subjects, without a statistically significant difference. Analysis of the histologic specimens revealed that the density of the regenerated bone was related to the density of the surrounding bone. The present study demonstrates the spontaneous healing of infrabony artificial defects, 2.5 mm diameter, in the jaw. The pure beta-TCP was resorbed simultaneously with new bone formation, without interference with the bone matrix formation. (Int J Periodontics Restorative Dent 2003;23:69 77 ...
Bioceramics 19: The Effect of Lif-Maleic Acid Added Calcium Aluminate Bone Cement and Ca-PMMA Composite Bone Cement on Bone Regeneration in Rat Calvarial Defects
The aim of this experimental study was to evaluate the effect of bovine lactoferrin (bLF)-loaded gelatin microspheres (GM) used in combination with anorganic bovine bone on bone regeneration in surgically created bone defects around tooth implants. Twenty-four uniform bone defects were created in the frontal bone via an extraoral approach in 12 domestic pigs. Twenty-four implants were placed at the center of the defects. In eight animals one of these defects was filled with 0.3 mL anorganic bovine bone while the other was left empty. In four animals, all defects were filled with 3 mg/defect bLF-loaded GM and anorganic bovine bone. All the defects were covered with collagen membranes. All animals were sacrificed after 10 weeks of healing, and the implants with the surrounding bone defects were removed en bloc. Undecalcified sections were prepared for histomorphometric analysis. The mean total area of hard tissue was 26.9 +/- 6.0% in the empty defect group, 31.8 +/- 8.4% in the graft group, and ...
Objectives: Guided bone regeneration (GBR) is a commonly utilized surgical technique in the craniofacial region. The transcriptional mechanisms associated with this type of bone regeneration are not well understood. The aim of this study was to characterize the transcriptome associated with GBR of a critical-size calvarial defect in the rat. Material and methods: Critical-size calvarial defects were created in six Wistar strain rats and treated according to the principles of GBR. The tissue filling the regenerating defect was harvested at 7 and 14 days. Total RNA was extracted and microarray analysis was carried out to identify the differences in the transcriptome between days 7 and 14. Results: Gene ontology (GO) analysis of the genes up-regulated at day 7 showed that immature wound healing-related mechanisms, such as protein metabolism and cell proliferation, were upregulated at this time point. Furthermore, the immuno-inflammatory process was also up-regulated at the earlier time point. In ...
A common design constraint in functional tissue engineering is that scaffolds intended for use in load-bearing sites possess similar mechanical properties to the replaced tissue. Here, we tested the hypothesis that in vivo loading would enhance bone morphogenetic protein-2 (BMP-2)-mediated bone regeneration in the presence of a load-bearing PLDL scaffold, whose pores and central core were filled with BMP-2-releasing alginate hydrogel. First, we evaluated the effects of in vivo mechanical loading on bone regeneration in the structural scaffolds. Second, we compared scaffold-mediated bone regeneration, independent of mechanical loading, with alginate hydrogel constructs, without the structural scaffold, that have been shown previously to facilitate in vivo mechanical stimulation of bone formation.. Contrary to our hypothesis, mechanical loading had no effect on bone formation, distribution, or biomechanical properties in structural scaffolds. Independent of loading, the structural scaffolds ...
DOI: 10.11607/prd.1175 This report describes a novel bone reconstructive technique based on guided bone regeneration for extensive three-dimensional hard tissue augmentation. This two-stage technique utilizes bioresorbable osteosynthesis plates, pins, and collagen membranes that form a physical barrier resembling a fence, which contains the bone graft biomaterials composed of a combination of deproteinized bovine bone matrix and autologous bone grafted from intraoral sites. This technique can result in significant bone regeneration with minimal patient discomfort. Four case reports are presented. Histologic analysis of specimens shows the presence of mature bone. This procedure yields favorable results for bone formation, implant placement, and patient satisfaction. (Int J Periodontics Restorative Dent 2013;33:129 136. doi: 10.11607/prd.1175 ...
Background/Aim. The mechanism of impaired bone healing in diabetes mellitus includes different tissue and cellular level activities due to micro- and macrovascular changes. As a chronic metabolic disease with vascular complications, diabetes affects a process of bone regeneration as well. The therapeutic approach in bone regeneration is based on the use of osteoinductive autogenous grafts as well as osteoconductive synthetic material, like a β-tricalcium phosphate. The aim of the study was to determine the quality and quantity of new bone formation after the use of autogenous bone and β-tricalcium phosphate in the model of calvarial critical-sized defect in rabbits with induced diabetes mellitus type I. Methods. The study included eight 4-month-old Chincilla rabbits with alloxan-induced diabetes mellitus type I. In all animals, there were surgically created two calvarial bilateral defects (diameter 12 mm), which were grafted with autogenous bone and β-tricalcium phosphate (n = 4) or served as ...
The aim of this study is to investigate the influence of electro-magnetic stimulation on bone regeneration and the effect on bacterial infection. Electro-magnetic stimulation is a promising technique and a powerful tool for the enhancement of bone regeneration. To optimize the amplitude of the electric field and also the magnetic flux density norm a finite element analysis (FEM) simulation was investigated. In conclusion, we demonstrate that a simulation of an electro-magnetic stimulation in an already applied stimulation chamber with DC current could generate suitable values. Future aims include an additional optimization of the magnetic flux density due to the variation of the current. In order to achieve this, a parameter sweep with different diameters of the area of interest will be performed. ...
The treatment of intrabony defects is a real challenge in molar teeth as it is chronic, slowly progressing disease which needs timely intervention. Periodontal inflammation associated with intrabony defect is not a separate entity as it secondarily affects the pulp causing retrograde pulpitis. However, treatment of these lesions will be complicated due to extensive bone loss. The tooth was endodontically treated followed by periodontal surgery to eliminate the deep periodontal pocket and promote bone fill in osseous defect. PepGen P-15 composited with platelet rich plasma was utilized for enhancing bone formation. The combination of these graft materials provides synergistic effect on bone regeneration.
Guided Tissue Bone Regeneration is used for patients with gum disease that have bone loss and mobility, to restore their smile and secure their teeth. Dr. Ronald H. Watkins performs procedures to promote bone regeneration at our offices in Phoenix, AZ . Call us today to discuss your options for bone regeneration.
Bone tissue engineering and regenerative medicine are promising strategies for treating bone diseases and reconstructing bone defects. For many years research has been dedicated to understanding the biochemical environment that is required to encourage bone regeneration and the desired properties of biocompatible scaffold materials. These studies demonstrate the potential for stem cell based therapies for bone regeneration. However the field of tissue regeneration is faced with the specific challenge to develop novel tissue regeneration approaches to produce tissue that can simultaneously support loading, but is also porous to allow for cell migration and diffusion of nutrients into the regenerated tissue to maintain viability. Dr. McNamaras research group develop mechanobiology based approaches (compression, vibration, fluid flow and hydrostatic bioreactors) for bone tissue regeneration and apply these methods to overcome limitations of biomaterial based in vitro approaches for bone tissue ...
Guided tissue bone regeneration helps the body regenerate bone around the gums after gum disease. Call Drs. Szymanowski, Periodontists in Sacramento, CA.
... by Jona J. Sela , Itai A. Bab Principles of Bone Regeneration PDF is a timely publication that
The growing science of hard-tissue engineering has introduced various principles and solutions to confront the challenge of bone reconstruction. The process of bone augmentation is mandatory for successful placement and integration of root form dental implants in atrophic jaws. Although different techniques have achieved a predictable amount of horizontal bone gain, vertical augmentation has proven to be a consistent challenge, with often less than desirable results.1 This is especially evident in the posterior mandible, where the inferior alveolar nerve further accentuates the limited amount of available bone height.2 Because of this lack of predictability, a large range of reconstructive techniques and materials have been used: onlay bone grafting, guided bone regeneration (GBR), and distraction osteogenesis to list a few. The advantages and disadvantages of each technique impart its applicability to particular circumstances.3,4 The gold standard, autogenous bone graft, has several ...
Springfield MA Periodontist offers guided bone & tissue regeneration to stabilize teeth or prepare the jaw for dental implants. 413-788-9058
BEGO Implant Systems GmbH & Co. KG, Bremen, Germany. The loss of volume of the alveolar ridge that regularly occurs after tooth extractions can compromise the hard and soft tissue situation for implants and thus the aesthetic outcome. The principle of membranesupported guided bone regeneration (GBR) is currently the most commonly used technique for bone regeneration in the dental practice. The separation of the rapidly proliferating soft tissue from the more slowly regenerating hard tissue creates a protected compartment in which damaged or lost bone tissue can be regenerated. Commercially available barrier membranes can be clearly differentiated from one another on the basis of several properties. Factors such as source tissue and preparation process have been just as exhaustively studied as the effect of the species from which the collagen was harvested or the networking properties. To what extent these factors are essential for the biodegradation time of a barrier membrane, for example, ...
... is used in dentistery, especially for the dental implant treatment when the bone volume is not adequate.
Regeneration is a process of restoring the biological object structure after its damage. There are three types of bone regeneration: physiological, re
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The overall aim of this thesis was to establish whether selected Leeds β-structure self- assembling peptides were suitable candidates for use in skeletal tissue engineering. This was addressed by first carrying out simple cytotoxicity studies on selected SAPs using an osteosarcoma cell line in vitro, followed by assessing extent of bone regeneration / repair and safety in vivo in a rabbit calvarial defect model. In vitro investigations revealed that the SAPs (P11-4, P11-8, P111-12, P11-1S, P11-16 and Pl1- 20) tested were cytocompatible, though the positively charged SAP P11-16 performed less well than other SAPs tested in the contact cytoxicity assay, possibly due to the presence of chemical contaminant introduced during the peptide purification process. Cell proliferation was generally superior on the negatively charged peptides compared with the positively charged peptides and cells appeared to thrive at the lower concentrations (30 mg/mL) of negatively charged SAPs compared with their ...
In an article in PLoS Medicine Gert Meijer (University Medical Centre...Until recently say the authors the use of bone grafts from a differe...Given all these problems with bone grafts scientists have attempted t...In their article the authors review the available data on bone tissue ...,Are,scientists,making,progress,in,being,able,to,regenerate,bone,tissue?,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
An idea struck. What if we could tap into the bodys ability to regenerate bone to help cancer patients? It was a novel concept … or so I thought.. High-grade bone cancers used to be a death sentence. If a person was lucky, he would get a limb amputated and live a few more years. Then chemotherapy came along and suddenly 70 percent of younger patients with these aggressive bone cancers were surviving.. Doctors could now treat the cancer with chemo, remove the tumors, and replace the bone defect with metal implants. However, metal things tend to break and wear out. As people got older, they needed multiple surgical interventions to fix or replace the implants. That meant hospital stays, risk of complications, sometimes infection.. Instead of medical implants, what if we could use the bodys natural ability to regenerate bone?I couldnt wait to tell my mentor.. "It is a great idea," he said. "But not a new idea.". Turns out a professor in Japan had been exploring this idea for 25 years already. ...
MIT chemical engineers have devised a new implantable tissue scaffold coated with bone growth factors that are released slowly over a few weeks. When applied to bone injuries or defects, this coated scaffold induces the body to rapidly form new bone that looks and behaves just like the original tissue. This type of coated scaffold could offer a dramatic improvement over the current standard for treating bone injuries, which involves transplanting bone from another part of the patients body - a painful process that does not always supply enough bone. Patients with severe bone injuries, such as soldiers wounded in battle; people who suffer from congenital bone defects, such as craniomaxillofacial disorders; and patients in need of bone augmentation prior to insertion of dental implants could benefit from the new tissue scaffold, the researchers say. "Its been a truly challenging medical problem, and we have tried to provide one way to address that problem," says Nisarg Shah, a recent Ph.D. ...
Crushed bone injuries are relatively uncommon compared to compound, oblique and transverse fractures, yet they typically occur in accidents where there is...
Cells, called osteochondroreticular (OCR) stem cells, were discovered by tracking a protein expressed by the cells. Using this marker, researchers at Columbia University Medical Center found that OCR cells self-renew and generate key bone and cartilage cells, including osteoblasts and chondrocytes.
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
Learn about OSSIX Bone grafting material, OSSIX PLUS and OSSIX Volumax resorbable collagen and barrier membranes, and OSSIX Graft cortical and/or cancellous bone material.
The device incorporates a structurally stable membrane (4, 4′, 34, 35) that incorporates a surface (15) to be bonded to a tissue to be regenerated, specifically a vital bone (2, 22, 38, 39). Means (9, 5, 6, 25, 36) are additionally provided whereby the membrane (4, 4′, 24, 35) is movable for the regeneration with a certain pulling force and speed. According to the invention the membrane (4, 4′, 24, 35) has, on its surface facing the tissue or bone, means (16) for the biological anchoring and adhesion for tissue or bone cells. These means (16) for the biological anchoring of tissue cells are specifically bone cells, protein molecules and/or osteoblasts (17), as well as indentations (45, 46, 48) and surface peaks (50) of the membrane.
LADDEC is processed cancellous bone of bovine origin with structure and chemical composition similar to that of human bone. It is a safe biocompatible bone graft that provides an excellent osteoconductive scaffold for rapid regeneration of bone and remodeling of the graft into host bone.
Non-healing skeletal defects are addressed in over 2.2 million surgical cases each year. Bone morphogenetic protein 2 (BMP2), the main growth factor for bone re...
Dr. Kammeyer continues to be on the leading edge of bone and tissue regeneration. Contact us at 623-556-5442 for further queries.
RODERIC (Repositori dObjectes Digitals per a lEnsenyament la Recerca i la Cultura) es el repositorio institucional de la Universitat de València. Se concibe como una ventanilla única para el acceso y la difusión de la producción digital de la Universitat. RODERIC responde al compromiso de la Universitat con el movimiento de acceso abierto al conocimiento adquirido con su adhesión a la Declaración de Berlín (30 Septiembre de 2008).
The last two decades have seen an explosion of knowledge and new techniques to regenerate periodontal tissues. Up until the 1980s most surgery was
Sigma-Aldrich offers abstracts and full-text articles by [A Tampieri, E Landi, F Valentini, M Sandri, T DAlessandro, V Dediu, M Marcacci].
Solutions Dental Implants offer soft tissue regeneration to encourage your bodys natural ability to regenerate bone and tissue. Call 623-556-5442
Reconstruction of craniofacial skeletal defects from both congenital and acquired etiologies can often present a daunting challenge. Contemporary strategies emp...
Dr Leandro Bolzoni from the University of Waikatos School of Engineering has been awarded a Health Research Council explorer grant worth $150,000.
31 years-old male patient was loss of anterior teeth for 1 year. . We have treated this case using Geistlich Bio-Oss® and Geistlich Bio-Gide® guide bone regeneration. After 6 months, the post-examination showed that that site had well-developed alveolar bone. After 1 year, permanent restoration was performed.. ...
Bone, Regeneration, Disease, Injury, Bone Regeneration, Microct, Microsphere, Rat, Tissue, Tomography, Cells, Growth, Regulation, Role, Time, Cell, Marrow, Nanofibers, Sphingosine, Birth
Sabra Dental has alternative regenerative materials that are used bone dental bone regeneration. Shop for alternative regenerative materials.
Connect and collaborate with Lorena Benito at University of Salamanca, with research interests in Bone regeneration biomaterials, on Mendeley.
Horse racing (global) December 25, 2009 causes many joint & bone injuries, speed-enhancing drugs given, 1,000 horses die each year on American race tracks. Hors
Question - Lump attached to tip of tailbone and it is painful. Ask a Doctor about diagnosis, treatment and medication for Tail bone injury, Ask an Orthopaedic Surgeon
In the clinic, bone defects resulting from infections, trauma, surgical resection and genetic malformations remain a significant challenge. In the field of bone tissue engineering, three-dimensional (3D) scaffolds are promising for the treatment of bone defects. In this study, calcium sulfate hydrate (CSH)/mesoporous bioactive glass (MBG) scaffolds were successfully fabricated using a 3D printing technique, which had a regular and uniform square macroporous structure, high porosity and excellent apatite mineralization ability. Human bone marrow-derived mesenchymal stem cells (hBMSCs) were cultured on scaffolds to evaluate hBMSC attachment, proliferation and osteogenesis-related gene expression. Critical-sized rat calvarial defects were applied to investigate the effect of CSH/MBG scaffolds on bone regeneration in vivo. The in vitro results showed that CSH/MBG scaffolds stimulated the adhesion, proliferation, alkaline phosphatase (ALP) activity and osteogenesis-related gene expression of hBMSCs. ...
Bone tissue engineering strategies require cells with high proliferative and osteogenic potential as well as a suitable scaffold to support the development of these as they form new bone tissue. In this study, we evaluated whether the differentiation stage of amniotic fluid stem cells (AFSC) could enhance the regeneration of critical sized femoral defects in a rat model. For this purpose, AFSC were seeded onto a starch-poly(ε-caprolactone) (SPCL) scaffold and were cultured in vitro in osteogenic culture media for different periods of time in order to obtain: i) undifferentiated cells, ii) cells committed to the osteogenic phenotype and iii) "osteoblast-like" cells. In vitro results indicate that AFSC were considered to be osteogenically committed by the end of week 2 and osteoblastic-like after week 3 in culture. Constructs composed of AFSC-SPCL scaffolds from each differentiation stage were implanted into critical sized femoral defects. The quality of new tissue formed in the defects was ...
This study analyzed the effect of the platelet count in platelet-rich plasma (PRP) on bone regeneration in vivo. Twenty male New Zealand white rabbits were used. PRP was produced using the Platelet Concentrate Collection System (PCCS) (3i, Miami, FL, USA). After inducing ketamine-xylazine anaesthesia, a self-tapping titanium screw (Branemark MK III TiUnite, 3.75 x 7 mm) was inserted in each distal femur; the femurs were randomized so that one side was treated with PRP while the other (control) was not. Intravital fluorochrome staining was performed on days 1, 7 (1.5 ml of 2% doxycycline/kg bodyweight), 14 (6% xylenol orange, 1.5 ml/kg), and 21 (1% calcein green, 5 ml/kg). Animals were euthanized on day 28 (n = 20). Specimens were prepared for histomorphological evaluation according to Donath and Breuner [J. Oral Pathol. 11 (1982) 318]. Comparing the bone regeneration (fluorochrome staining) in the 4-week implants (n = 19), the only significant difference (sign test, P = 0.004) was seen with intermediate
Edentulism refers to a state of full or partial lack of teeth. This situation may interfere with essential functions such as mastication, speech and even appearance.. Dental implants inserted to the mandible or maxilla is a common treatment modality aiming to restore edentulus alveolar ridges by providing support and anchorage for removable or fixed dental prosthesis.There are cases which in addition to a lack of teeth suffer from lack of sufficient bone tissue volume to support the dental implant.A situation like this may originate from a variety of reasons such as residual bone atrophy, prior alveolar bone destruction due to periodontal disease and even a traumatic tooth extraction. In such cases, a routine alveolar bone augmentation is done to enable a dental implant installation at this site.Guided bone regeneration (GBR) is a widely used technique used to augment edentulus bone ridges. It relies on an inert membrane covering a bone substitute placed over the bony site requiring ...
Guided Bone Regeneration, aka Bone Grafting, is a procedure that stimulates the formation of new bone in your jaw where bone is deficient or lacking.
Guided bone regeneration (GBR) is a reconstructive procedure of alveolar ridge using membranes. This procedure is indicated when there is no sufficient bone for implantation, or in the case of optimal implant installation for esthetic or functional needs. GBR can be performed before implant placement, when there is not enough bone for initial stability of implants and less predictable outcomes (staged approach), or performed simultaneously with implantation (combined approach). GBR techniques have been used for vertical and horizontal ridge augmentations with acceptable results. This literature review discusses the background, principles of GBR, the materials used in GBR (types of membranes and bone grafts), success criteria and long term results of GBR.
Guided Bone Regeneration (GBR) involves placing mechanical barriers in order to protect blood clots and prevent bone defect from the surrounding connective tissue.. Come and experience a hassle free experience.. Book an Appointment. ...
Evaluation of guided bone regeneration in rabbit femur using collagen membranes.: The aim of the study was to evaluate the mechanical performance and the struct
Guided Tissue Bone Regeneration is used for patients with gum disease that have bone loss and mobility, to restore their smile and secure their teeth. Chula Vista Periodontics performs procedures to promote bone regeneration at our offices in Chula Vista, CA . Call us today to discuss your options for bone regeneration.
Enhanced Critical Size Defect Repair in Rabbit Mandible by Electrospun Gelatin-β-TCP Composite Nanofibrous Membranes. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
experimental studies have been performed in order to evaluate the behavior of different types of biomaterials involved in the process of tissue and bone regeneration. The guided bone regeneration (GBR) principles are applied in the rebuilding of periodontal tissues, damaged by the periodontal inflammatory process. Since the introduction of GBR biological principles, a wide range of materials have been tested and used as a physical barrier. At present, the autogenous material continues to be considered the best choice when reconstruction of bone defects is intended. Calcium phosphate ceramics have been widely applied as bone substitutes, coatings, cements, drug delivery systems and tissue engineering scaffolds due to their resemblance to the mineral portion of the bone tissue, relative ease in processing and good cell attachment. 40 patients (25 males and 15 females) planned to receive bone regeneration procedure were included in the study. 20 patients were treated for bone regeneration using ...
Strategies for bone tissue engineering and regeneration rely on bioactive scaffolds to mimic the natural extracellular matrix and act as templates onto which cells attach, multiply, migrate and function. Of particular interest are nanocomposites and organic-inorganic (O/I) hybrid biomaterials based on selective combinations of biodegradable polymers and bioactive inorganic materials. In this paper, we review the current state of bioactive and biodegradable nanocomposite and O/I hybrid biomaterials and their applications in bone regeneration. We focus specifically on nanocomposites based on nano-sized hydroxyapatite (HA) and bioactive glass (BG) fillers in combination with biodegradable polyesters and their hybrid counterparts. Topics include 3D scaffold design, materials that are widely used in bone regeneration, and recent trends in next generation biomaterials. We conclude with a perspective on the future application of nanocomposites and O/I hybrid biomaterials for regeneration of bone.
GBR is a technique used for the regeneration of lost alveolar bone by the help of a grafting material and a barrier membrane. The defect is filled with a bone graft material (allogeneic-, xenogeneic- or alloplastic bone substitute materials) that serves as a scaffold for ingrowth of bone forming cells (osteoconduction) and blood vessels, and prevents collapse of the overlying membrane and soft tissue. The membrane acts as a barrier agains ingrowth of fast proliferating connective tissue cells, hence, giving the bone forming cells time and space for the osseous regeneration of the defect. Moreover, the membrane stabilizes the bone graft material and prevents the migration of particles.
Regenics bone regeneration synthetic materials regenics bone regeneration help regeneration of bone synthetic materials materials regenics synthetic
A biologic artificial bone includes an artificial fiber material formed from a synthetic polymer with mechanical properties similar to type I collagen. A biocompatible liquid substance is impregnated in the fiber material that hardens and stiffens the fiber material. A bone substitute is impregnated in the hardened and stiffened fiber material forming an artificial bone composite. Vascular channels are formed in the artificial bone composite to facilitate in-growth of vessels and bone forming cells. The construction and methods achieve an artificial composite structure that is similar to natural bone with comparable properties.
Recent studies on bone regeneration demonstrate the use of low cost and stable small molecules, which avoid the adverse effect and high cost of growth factors. Herein, we investigate the chemotactic, angiogenic and osteoinductive potential of a prostacyclin analogue, ONO-1301, when delivered through a biomim
Degradable bone graft substitute for large-volume bone defects is a continuously developing field in orthopedics. With the advance in biomaterial in past decades, a wide range of new materials has been investigated for their potential in this application. When compared to common biopolymers within the field such as PLA or PCL, elastomers such as polyurethane offer some unique advantages in terms of flexibility. In cases of bone defect treatments, a flexible soft filler can help to establish an intimate contact with surrounding bones to provide a stable bone-material interface for cell proliferation and ingrowth of tissue. In this study, a porous filler based on segmented polyurethane incorporated with poly l-lactic acid was synthesized by a phase inverse salt leaching method. The filler was put through in vitro and in vivo tests to evaluate its potential in acting as a bone graft substitute for critical-sized bone defects. In vitro results indicated there was a major improvement in biological response,
Open tibia fractures have a 15% or higher rate of not healing. Those fractures which do not heal are typically treated with bone from the hip (iliac crest autograft; or ICBG). The use of ICBG bone with the treatment of delayed unions/non-unions with critical defect, although successful, has its drawbacks. The bone graft sources are limited and the procedure is associated with additional operating room time plus a second incision with increased risk of infection, post operative pain and increased hospital stay. The purpose of this study is to determine if Rh-BMP2, a new bone graft substitute, is at least as effective as using bone from the hip (autograft) to help promote healing of open, tibia (shin bone) fractures.. Research Questions:. Primary:. What is the relative effect of rhBMP-2 versus autogenous ICBG on rates of union in patients with critical size defects following tibial shaft fractures?. Null hypothesis #1: rhBMP-2 has the same union rate when used in critical-sized defects as does ...
Adult stem cells are an inexhaustible source of multipotent cells, which can differentiate into various cell lines. Thanks to these properties, adult stem cells can be used in regenerative medicine for various purposes. Dental pulp stem cells (DPSC) can give rise to different cells of mesenchymal origin, such as osteoblasts, adipocytes, chondrocytes and muscle cells. At present, DPSC applications are mainly focused on bone regeneration in dental/maxilla-facial and orthopedic surgery. Current methods for preserving and banking dental pulp stem cells include steps in which DPSC are recovered from tooth, amplified and then stored in liquid nitrogen for further application. The Italian medical research centre has developed a simpler and inexpensive method for cryopreserving a tooth with its dental pulp stem cells. Tooth laser perforation allow to access the root canal without overheating the dental pulp; this step contributes to ensure the integrity of the cryopreserved dental tissue, absence of ...
AlloDerm GBR by BioHorizons is used as an effective barrier membrane in oral reconstruction and can be remodeled into the patients own tissue.
PURPOSE: The aim of this study was to test whether or not implants associated with bone regeneration show the same survival and success rates as implants placed in native bone in patients requiring both forms of therapy. MATERIAL AND METHODS: Thirty-four patients (median age of 60.3 years, range 18-77.7 years) had been treated 5 years before the follow-up examination. Machined screw-type implants were inserted following one of two surgical procedures: (1) simultaneously with a guided bone regeneration (GBR) procedure, which involved grafting with xenogenic bone substitute material, autogenous bone or a mixture of the two and defect covering with a bio-absorbable collagen membrane (test) and (2) standard implantation procedure without bone regeneration (control). For data recording, one test and one control implant from each patient were assessed. Examination included measurements of plaque control record (PCR), probing pocket depth (PPD), bleeding on probing (BOP), width of keratinized mucosa ...
Records of 14 patients (7 male, 7 female) with a mean (SD) age of 36.78 (13.9) years who were treated for soft tissue recessions around implant-supported restorations in the maxillary central or lateral incisor location were analysed. Implant diameters ranged from 3.3-4.7 mm. All patients had bone loss confined to the labial surface of the implant. A solvent-dehydrated particulate mineralized allograft (Puros Cancellous Bone Allograft, Zimmer Biomet Dental, Palm Beach Gardens, FL) and a resorbable membrane (CopiOs Pericardium, Zimmer Biomet Dental) were used in a GBR surgical procedure in combination with a roughened titanium tenting screw placed 3-4 mm below the implant platform to restore unesthetic defects in the anterior maxilla.. Results ...
The most promising attempts to achieve bone regeneration artificially are based on the application of mediators such as bone morphogenetic proteins (BMPs) directly to the deficient tissue site. BMPs, as promoters of the regenerative process, have the ability to induce de novo bone formation in various tissues, and many animal models have demonstrated their high potential for ectopic and orthotopic bone formation. However, the biological activity of the soluble factors that promote bone formation in vivo is limited by diffusion and degradation, leading to a short half-life. Local delivery remains a problem in clinical applications. Several materials, including hydroxyapatite, tricalcium phosphate, demineralised bone matrices, poly-lactic acid homo- and heterodimers, and collagen have been tested as carriers and delivery systems for these factors in a sustained and appropriate manner. Unfortunately these delivery vehicles often have limitations in terms of biodegradability, inflammatory and immunological
It is becoming rare today to come across simple cases in Periodontics; our specialty has come to face complex cases where hard and soft tissue deficiencies are quite common. These suggested protocols and schematic approaches were developed to help the surgical practitioner visualize and divide the problem into a predictable step-by-step workflow. The utilization of 3-D printed CBCT studies of the treatment planned surgical sites was shown to be integral in patient care and clinical outcomes. Every step is dictated by biology; all incision designs, flap management techniques, and biomaterials used have been selected to maximize the blood supply in the area and minimize trauma to the vascular network that nourishes our surgical site. ...
Large bone defects, such as those resulting from tumor excision, critical size defect fractures, or non-union, remain a clinical problem in bone reconstructive surgery. Current treatments involving autologous or allogenic bone grafts present the problem of implant availability and quality, or associated infection and immune response risks, respectively. In addition, as bone formation is highly dependent on the presence of osteogenic cells at the implant site, vascularization is also a major concern, as inadequate bone vascularization is typically associated with decreased bone formation, tissue necrosis, and implant integration failure, leading to impaired bone repair. The bone biology focus area mainly aims to study the cellular mechanisms involved in the different phases of bone healing and their interplay for a better understanding and further monitoring of the process. The induction of vessels within an artificial bone substitute, by co-seeding endothelial progenitors and mesenchymal stromal ...
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In the 15-minutes film, details of the highly complex intercellular processes in bone regeneration are presented by computer animation. It is the latest module of the Cell-to-Cell Communication series by Quintessence International, and visualizes the invisible yet fascinating world of signals and signaling within the human body. Several Board Members of the Osteology Foundation were as members of the Advisory Board for the film involved, such as Mauricio Araújo, Daniel Buser, and Reinhard Gruber. The full-length expert version of the film can now be watched online and free of charge for registered users of THE BOX. ...
TY - JOUR. T1 - Targeted delivery system for juxtacrine signaling growth factor based on rhBMP-2-mediated carrier-protein conjugation. AU - Liu, Hsia Wei. AU - Chen, Chih Hwa. AU - Tsai, Ching Lin. AU - Hsiue, Ging Ho. PY - 2006/10. Y1 - 2006/10. N2 - We propose a model of artificial juxtacrine signaling for the controlled release of recombinant human bone morphogenetic protein-2 (rhBMP-2) suitable for guided bone regeneration. A porous three-dimensional scaffold of poly-(lactide-co-glycolide) was fabricated by means of gel molding and particulate leaching. Collagen immobilization onto the scaffold surface was produced by performing photo-induced graft polymerization of acrylic acid, and rhBMP-2 was tethered to the collagenous surface by covalent conjugation. On pharmacokinetic analysis, in vitro enzyme-linked immunosorbent and alkaline phosphatase assays revealed sustained, slow release of rhBMP-2 over 28 days, with a cumulative release of one third of the initial load diffusing out of the ...
Dr. Manitha B. Nair, Dr. Deepthy Menon, and Shantikumar V. Nair, "Porous Composite Fibrous Scaffold for Bone Tissue Regeneration", U.S. Patent 15/341,866 2016.. ...
Principal Investigator:Nagai Hirokazu, Project Period (FY):2015-04-01 - 2018-03-31, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Surgical dentistry
The use of human bone marrow-derived mesenchymal stem cells (hBMSCs) has been tried successfully in fracture treatment due to their potential to regenerate bone in patients who have lost large areas of bone from either disease or trauma. Recently, many attempts have been made to enhance the function of stem cells using carbon nanotubes, graphenes, and nano-oxides.. In the study, Professor Kim and Professor Suh examined the C₃N₄sheets. They discovered that this material absorbs red light and then emits fluorescence, which can be used to speed up bone regeneration. Professor Kims team synthesized carbon nitrogen derivatives from melamine compounds. Then, they analyzed the light-absorbing characteristics of C₃N₄sheets at a wavelength range of 455-635 nanometers (nm). As a result, the C₃N₄sheets were found to emit fluorescence at the wavelength of 635 nm when exposed to red light in a liquid state. At this time, the released electrons induced calcium to accumulate in the ...
Plastic and Aesthetic Research covers technical and clinical studies related to plastic and aesthetic surgery, such as plastic and aesthetic materials, plastic surgery, oral and maxillofacial surgery, orthopedic surgery, ophthalmoplasty, dentistry etc.
In their mission to design new biomaterials that promote tissue regeneration, Drexel University researchers have identified how inflammation, when precisely controlled, is crucial to bone repair.. Their findings, published this week in the Journal of the Royal Society Interface, show that a new type of ceramic scaffold causes inflammatory cells to behave in a way that is more regenerative than scaffolds that are currently used clinically.. Critical-size bone defects - due to tumor removals, gun shot wounds and other traumatic injuries - cannot heal on their own, so scientists are searching for the perfect combination of material and mechanism that will guide the growth of new tissue.. "Your cells cant swim. Any time you have a large piece of bone missing, a scaffold is needed to close that gap," said Kara Spiller, PhD, an associate professor in the School of Biomedical Engineering, Science and Health Systems.. Spillers collaborators at the University of Sydney in Australia recently designed ...
TY - JOUR. T1 - The critical-size supraalveolar peri-implant defect model. T2 - Characteristics and use. AU - Wikesjö, Ulf M E. AU - Susin, Cristiano. AU - Qahash, Mohammed. AU - Polimeni, Giuseppe. AU - Leknes, Knut N.. AU - Shanaman, Richard H.. AU - Prasad, Hari S.. AU - Rohrer, Michael D.. AU - Hall, Jan. PY - 2006/11/1. Y1 - 2006/11/1. N2 - Objective: Novel implant technologies and reconstructive therapies for alveolar augmentation require pre-clinical evaluation to estimate their biologic potential, efficacy, and safety before clinical application. The objective of this report is to present characteristics and use of the critical-size, supraalveolar, peri-implant defect model. Methods: Bilateral extraction of the mandibular premolars was performed in 12 Hound Labrador mongrel dogs following horizontal surgical cut-down of the alveolar ridge approximating 6 mm. Each jaw quadrant received three custom-produced TiUnite™, Ø4.0 × 10 mm threaded implants placed into osteotomies prepared ...
Davidson NC Periodontist offers guided bone & tissue regeneration to stabilize teeth or prepare the jaw for dental implants. 704-892-0644
TY - JOUR. T1 - In vivo effectiveness of a glycerol-compounded demineralized freeze-dried bone xenograft in the rat calvarium. AU - Matzenbacher, Scott A.. AU - Mailhot, Jason M.. AU - McPherson, James C.. AU - Cuenin, Michael F.. AU - Hokett, Steven D.. AU - Sharawy, Mohamed M.H.. AU - Peacock, Mark E.. PY - 2003/11/1. Y1 - 2003/11/1. N2 - Background: Demineralized freeze-dried bone (DFDB) is commonly hydrated with sterile water into a paste-like consistency for improved clinical handling or reconstituted with biodegradable barriers, such as glycerol, to promote handling and wound stability following human periodontal surgery. The purpose of this study was to evaluate the in vivo effects of glycerol-compounded human DFDB on bone formation in the rat calvarial critical-sized defect (CSD) model. Methods: Forty-eight adult male Harland Sprague-Dawley rats were assigned to one of four treatment groups: glycerol, DFDB, DFDB plus glycerol, or a non-grafted control, and placed into 8 mm calvarial ...
Köp böcker av Daniel Buser: ITI Treatment Guide: Volume 4; ITI Treatment Guide: 3 Implant Placement in Post-extr...; 20 Years of Guided Bone Regeneration in Implant Denti... m.fl.
Principal Investigator:HOSOKAWA Ryuji, Project Period (FY):2002 - 2003, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:補綴理工系歯学
ReproBone fusion bone graft substitute is an innovative, synthetic fusion of hydroxyapatite/tri-calcium phosphate granules in an osteostimulative carrier.
The New York-based startup Epibone intends to begin human testing on a procedure that will utilize stem cells to regenerate living bone tissue. The researchers, originally from Columbia University, will apply autologous [the patients own] stem cells to nanofiber scaffolding of the desired size and shape and direct the stem cells to differentiate into a physical and genetic replica of the patients own bone. Continue reading →. ...
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August 27th, 2017 Updates:. Cameron provided insight for a DidYouKnow.it article about disease, as it relates to oral hygiene. Things like heart disease, dementia, and many other ailments can actually be prevented with proper tooth care. Probably didnt even realize as much. Worth the read if you want more information on how you can make more intelligent life choices, just by brushing your teeth.. Dr. Cameron Clokie is a pioneer in a cutting-edge bone regeneration technique using bone morphogenetic protein or BMP. BMP was discovered by scientists working at U.C.L.A. in the 1950s. Dr. Clokie is an oral and maxillofacial surgeon. He graduated dental school in 1985 with his DDS. To further his training, he attended McGill University.. In 1992 he got a Ph.D. in bone regeneration with a focus on dental implants. Dr. Clokie learned about the use of BMP through his work with Dr. Marshall Urist, a noted orthopedic surgeon.. In 2003 Dr. Clokie became internationally-known when the jawbone of one of his ...
August 27th, 2017 Updates:. Cameron provided insight for a DidYouKnow.it article about disease, as it relates to oral hygiene. Things like heart disease, dementia, and many other ailments can actually be prevented with proper tooth care. Probably didnt even realize as much. Worth the read if you want more information on how you can make more intelligent life choices, just by brushing your teeth.. Dr. Cameron Clokie is a pioneer in a cutting-edge bone regeneration technique using bone morphogenetic protein or BMP. BMP was discovered by scientists working at U.C.L.A. in the 1950s. Dr. Clokie is an oral and maxillofacial surgeon. He graduated dental school in 1985 with his DDS. To further his training, he attended McGill University.. In 1992 he got a Ph.D. in bone regeneration with a focus on dental implants. Dr. Clokie learned about the use of BMP through his work with Dr. Marshall Urist, a noted orthopedic surgeon.. In 2003 Dr. Clokie became internationally-known when the jawbone of one of his ...
The goal of Periodontal therapy is to halt the disease progression and prevent its recurrence, and restore the lost periodontal structure which occured as the result of the disease destruction. The later goal prompts us to evaluate the concept of "new attachment" or "regeneration", and "reattachment" or "repair". Each concepts will lead to different mode of periodontal therapy, and ultimately different result. New attachment is the ideal, desired goal, which each periodontist today are trying to achieve in every possible way. Continue reading →. ...
PRF production course and bone grafting principles taught by Dr. Kayvon Javid DICOI, FCII, AFWCLI, CPT 1, Certified Phlebotomy Trainer.
The leading dental and oral heathcare site affords access to the AEGIS dental archives, as well as news, product information, and other online-only articles and features.
Xenogenic graft of bone origin has been used to favor bone regeneration and toreduce autogenous bone needs. The purpose of this study was to evaluate thebone repair induced by particulate bovine organic bone grafted in rabbitcalvaria. Two standardized bone defects were prepared in both parietal of 20adult rabbits. The defects were filled by clot, autograft, medular organic bovinebone or cortical organic bovine bone. Thirty days following surgery animalswere killed; the calvaria were removed, fixed in formol, demineralized in EDTAand embedded in paraffin. Histological sections were stained in HE or MalloryTrichrome and analyzed by light microscope. On group filled with clot only thehalf of the defect was repaired by new bone tissue, which was formed fromlesion border, central area presented cellular connective tissue. In defects filledwith autograft almost all defect was repaired by bone tissue. Defects graftedwith medular or cortical bovine bone exhibited near ¼ of defect filled by bonetissue, ...
This annotation describes some early rat studies which conclude that parathyroid hormone (PTH) has more dramatic stimulatory effects on bone repair than on untraumatized bone. It also suggests, based on the effects of PTH on osteoblasts, that it is more likely to accelerate normal fracture healing than to prevent nonunion. The only 2 controlled clinical trials that have been published are critically discussed. Although both are encouraging and appear to show acceleration of normal fracture healing, they have methodological shortcomings that preclude definitive conclusions.. ...
When stem cells are used to regenerate bone tissue, many wind up migrating away from the repair site, which disrupts the healing process. But a techni
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Orthogen, LLC is focused on developing solutions for bone regeneration through application of nanotechnology. While in a bone graft is a surgical procedure that replaces missing bone with material from the patients own body
Paul Sharpe, a specialist in regenerative dentistry (Dental Institute of Kings College, London), has developed a new procedure whereby stem cells are cultivated to form a bud which is inserted in the socket of a missing tooth. Within a few months, it matures into a fully formed tooth. Sharpe and his team set up a company, Odontis, to exploit the technology, and received £400,000 funding from the National Endowment for Science, Technology and the Arts and the Wellcome Trust, but nothing more has emerged from their lab since 2004. Technical details of the method are described in Sharpes patents : WO2006024856 ("Jaw Bone Augmentation using Tooth Primordium"), US7588936 ("Generating Teeth from Bone Marrow cells"), and US7497686 ("Bone Regeneration ...
The models currently used for the simulation of bone regeneration are all of the continuum type, describing only a single time and length scale. In the case of bioregulatory models, many of the mathematical expressions used to describe phenomena such as migration and proliferation are derived from actual processes taking place at a lower level. One example is the diffusion term describing random cell migration, which is derived from a probabilistic micro-model of a random walk process (Murray 2002). An explicit incorporation of other levels might lead to additional insights into the dynamics of the fracture healing process. In the simulation of tumour development and treatment, multi-scale models are frequently used to explicitly model the cell cycle and angiogenesis (Anderson & Chaplain 1998; Alarcon et al. 2004) with the specific aim of the in silico design and testing of new therapies (Byrne et al. 2006; McDougall et al. 2006; Anderson & Quaranta 2008).. For the coupled mechanobioregulatory ...
Mesentechs bone targeting technology allows for the development of multiple products across a wide-range of clinical conditions, from bone regeneration, to treatment of bone infections and cancers within bone.. ...
The idea of a bioactive surface coating that enhances bone healing and bone growth is a strong focus of on-going research for bone implant materials. Enamel matrix derivate (EMD) is well documented to support bone regeneration ...
Bone tissue damages can derive from diseases such as osteogenesis imperfecta, osteoarthritis, osteomyelitis, and osteoporosis, or from traumatic injury, orthopaedic surgeries and primary tumour resection (Porter et al. 2009 Biotechnol Progress). In particular, non-critical bone defects and voids represent a hot spot for mechanical stresses that can cause fractures, thus it is necessary to accelerate their healing (Jawad et al. 2013 J Orthop Res). Moreover, spinal fusion, maxillary sinus floor elevation, guided bone regeneration, represent other clinical cases in which it is necessary to provide substitutes for bone tissue regeneration. (Mardas et al. 2010 Clin Oral Impl Res) The use of synthetic bone substitutes reduces surgical procedures and the risk of infection or immunogenicity, and decreases the risk of disease transmission (Mottaghitalab et al 2015 J Control Rel; Porter et al. 2009 Biotechnol Progress). Moreover, synthetic scaffolds can be loaded with bioactive molecules or cells before ...
TY - JOUR. T1 - Biological advantages of porous hydroxyapatite scaffold made by solid freeform fabrication for bone tissue regeneration. AU - Kwon, Byeong Ju. AU - Kim, Jungsung. AU - Kim, Yong Hwa. AU - Lee, Mi Hee. AU - Baek, Hyun Sook. AU - Lee, Dae Hyung. AU - Kim, Hye Lee. AU - Seo, Hyok Jin. AU - Lee, Min Hyeon. AU - Kwon, Soon Young. AU - Koo, Min Ah. AU - Park, Jong Chul. PY - 2013/7/1. Y1 - 2013/7/1. N2 - Presently, commercially available porous bone substitutes are manufactured by the sacrificial template method, direct foaming method, and polymer replication method (PRM). However, current manufacturing methods provide only the simplest form of the bone scaffold and cannot easily control pore size. Recent developments in medical imaging technology, computer-aided design, and solid freeform fabrication (SFF), have made it possible to accurately produce porous synthetic bone scaffolds to fit the defected bone shape. Porous scaffolds were fabricated by SFF and PRM for a comparison of ...
Background. Surgical removal of mandibular third molars results in pain, swelling and bony defects, causing prolonged postoperative recovery. The growth factors present in platelet-rich plasma (PRP) can accelerate the healing, thereby shortening postoperative recovery period. This study was undertaken to evaluate the role of PRP in postoperative socket healing, pain, swelling and bone regeneration following surgical removal of impacted mandibular third molars. Methods. The present case‒control study was conducted on 20 patients with identical bilateral mandibular third molar impaction. PRP was placed randomly on one side of 3rd molar extraction socket and the contralateral side was used as control. Evaluation of soft tissue healing, pain, swelling and radiologic bone density was carried out. Results. Soft tissue healing was better in the PRP compared to the control site. Immediate postoperative assessment of pain scores showed no significant difference between the two groups (Mann-Whitney U test). On
The goal of our research was to prove that dental follicle stem cells are a valuable cell source in improving bone regeneration on titanium implants surfaces. The dental follicle harvesting procedure is easy to undertake since it can be performed in relation to several surgical operations, impacted tooth extraction or even less invasive tooth disclosure. The search for alternative sources of mesenchymal stem cells (such as the dental follicle) is of considerable importance because bone marrow aspiration is an invasive procedure [1] and there are significant age-related decreases in the frequency and differentiation potential of bone-marrow-derived MSCs [12]. Compared to other stem cell sources from the oral cavity, as tooth pulp, the dental follicle is a considerably larger tissue [2], is easily accessible and dental follicle stem cells have a higher proliferation capacity than stem cells from the tooth pulp [13].. One innovative aspect of this study is that the follicular sac can be harvested ...
TY - JOUR. T1 - Effect of platelet-rich plasma on the healing of intrabony defects treated with beta tricalcium phosphate and expanded polytetrafluoroethylene membranes. AU - Döri, Ferenc. AU - Huszár, Tamás. AU - Nikolidakis, Dimitris. AU - Tihanyi, Dora. AU - Horváth, Attila. AU - Arweiler, Nicole B.. AU - Gera, I.. AU - Sculean, Anton. PY - 2008/4. Y1 - 2008/4. N2 - Background: Regenerative periodontal therapy using platelet-rich plasma (PRP) and different types of bone substitutes with or without guided tissue regeneration (GTR) has been proposed as a modality to enhance the outcome of regenerative surgery. However, there are limited data from controlled clinical studies evaluating the effect of PRP on the healing of deep intrabony defects treated with a combination of bone substitutes and GTR. The aim of this study was to clinically evaluate the effect of PRP on the healing of deep intrabony defects treated with beta tricalcium phosphate (β-TCP) and GTR by means of a non-bioresorbable ...
PURPOSE: The aim of this study was to compare ChronOS (β-tricalcium phosphate), Bio-Oss, and their addition to an autogenous bone graft in a 1:1 ratio in human maxillary sinus bone augmentation. MATERIALS AND METHODS: Thirty maxillary sinuses were divided in 5 groups: group 1 included 6 maxillary sinuses grafted with autogenous bone graft alone; group 2 included 6 maxillary sinuses grafted with ChronOS; group 3 included 6 maxillary sinuses grafted with ChronOS and autogenous bone graft in a 1:1 ratio; group 4 included 6 maxillary sinuses grafted with Bio-Oss; and group 5 included 6 maxillary sinuses grafted with Bio-Oss and autogenous bone graft in a 1:1 ratio ...
Qinge formula (QEF), prepared from an ancient Chinese recipe, was previously suggested to regulate bone metabolism and improve bone mineral density in patients with osteoporosis. To study the effects of medicated serum containing QEF on the in vitro differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) isolated from the proximal femurs of postmenopausal osteoporosis (PMOP) mice. Using an established mouse model of PMOP, mononuclear cells were isolated from the bone marrow present in the proximal femurs and cultured. PMOP mice were also randomly divided into four groups: the untreated group (Group A) and the groups treated with respectively low (Group B), medium (Group C), and high (Group D) concentrations of QEF. Serum was isolated from each and used to treat the cultured BMSCs in conjunction with recombinant human bone morphogenetic protein-2 (rhBMP-2). Cell morphology, proliferation rates, intracellular alkaline phosphatase (ALP) activity, and transforming growth factor-beta 1 (TGF
Bone regeneration[edit]. EGF plays an enhancer role on osteogenic differentiation of dental pulp stem cells (DPSCs) because it ... These data suggests that DPSCs in combination with EGF could be an effective stem cell-based therapy to bone tissue engineering ...
Bone Regeneration and Repair. Totowa, New Jersey: Humana Press. 2005. pp. 225-239. ISBN 978-0-89603-847-9. ... bone graft or artificial bone substitute is packed between the vertebrae to help them heal together.[1] In general, fusions are ... or artificial bone substitutes-to help the bones heal together.[1] Additional hardware (screws, plates, or cages) is often used ... Harvesting of bone graft (if autograft is used) [3]. Within a few days[edit]. *Wound infections - risk factors include old age ...
"Autogenous injectable bone for regeneration with mesenchymal stem cells and platelet-rich plasma: tissue-engineered bone ... Kraus KH, Kirker-Head C (April 2006). "Mesenchymal stem cells and bone regeneration". Vet Surg. 35 (3): 232-42. doi:10.1111/j. ... Bone repair[edit]. Bone has a unique and well documented natural healing process that normally is sufficient to repair ... Within four weeks of placing the scaffold, newly formed bone begins to integrate with the old bone and within 32 weeks, full ...
Tissue regenerationEdit. Collagen scaffolds are used in tissue regeneration, whether in sponges, thin sheets, or gels. Collagen ... Type I: skin, tendon, vasculature, organs, bone (main component of the organic part of bone) ... doi:10.1016/j.bone.2009.10.035. ISSN 8756-3282.. *^ Guillerminet, F.; Fabien-Soulé, V.; Even, P. C.; Tomé, D.; Benhamou, C.-L ... "Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice". Osteoporosis International. 23 ...
Their potential and pitfalls for bone tissue regeneration and engineering". Nanomedicine: Nanotechnology, Biology and Medicine ... doi:10.1016/j.bone.2008.04.013. PMID 18541467.. *^ Dalton, Aaron (15 August 2005). Nanotubes May Heal Broken Bones. Wired. ... Haddon, Robert C.; Laura P. Zanello; Bin Zhao; Hui Hu (2006). "Bone Cell Proliferation on Carbon Nanotubes". Nano Letters. 6 (3 ... Motta, M.; Moisala, A.; Kinloch, I. A.; Windle, Alan H. (2007). "High Performance Fibres from 'Dog Bone' Carbon Nanotubes". ...
Slow bone regeneration. This is particularly common in patients who smoke intensively during the lengthening process[citation ... Gavriil Ilizarov determined that bone fragments could be carefully pulled apart without disrupting their alignment. These bone ... 2. Solomin L.N. "Bases of osteosynthesis per bone with Ilizarov Apparatus", publishing office ELBI-Spb, 2005 3. Goldreyer M.M ... The apparatus he initially used was modified to support the lengthening of finger (phalanx) bones. The first experiments ...
... to collect and study the human temporal bone, and to encourage temporal bone donation. In 1992 the NIDCD National Temporal Bone ... and regeneration biology Cochlear implants Surgical therapy for otosclerosis Hair cell regeneration Hearing aids technology ... The DRF funded research led, in 1987, to the discovery of spontaneous regeneration of hair cells in chickens, thus igniting the ... Edge AS, Chen ZY (2008). "Hair cell regeneration". Current Opinion in Neurobiology. 18 (4): 377-82. doi:10.1016/j.conb.2008.10. ...
They would have fewer side-effects, while still promoting muscle and bone tissue growth and regeneration. These claims are, ... broken bones and pain. Muscle atrophy results from a co-morbidity of several common diseases, including cancer, AIDS, ... when the patient has a primary injury such as an immobilized broken bone (set in a cast or immobilized in traction), for ...
"Bone muscle crosstalk targets muscle regeneration pathway regulated by core circadian transcriptional repressors DEC1 and DEC2" ... BHLHE41 knockout mice had increased post-natal regeneration of muscle after injury. However, these mice showed no deficits in ...
Cassidy JW (2014). "Nanotechnology in the regeneration of complex tissues". Bone and Tissue Regeneration Insights. 5: 25-35. ... Artificial bone marrow Artificial bone Laboratory-grown penis Oral mucosa tissue engineering Foreskin Tissue engineering ... their potential and pitfalls for bone tissue regeneration and engineering". Nanomedicine: Nanotechnology, Biology and Medicine ... Recently there has been a trend towards the use of mesenchymal stem cells from bone marrow and fat. These cells can ...
The company focusses on bone regeneration. From 2008 until 2010 he was not only CEO but also managing director of the company. ... bone morphogenetic protein-7) to initiate rapid bone formation". J Bone Miner Res. 12: 1584-95. doi:10.1359/jbmr.1997.12. ... Ripamonti, U; Duneas, N (1998). "Tissue morphogenesis and regeneration by bone morphogenetic proteins". Plast Reconstr Surg. ... Tissue morphogenesis and regeneration by bone morphogenetic proteins. (January 1998) Tissue Engineering of Bne, From Concept To ...
"Autogenous injectable bone for regeneration with mesenchymal stem cells and platelet-rich plasma: tissue-engineered bone ... Kraus KH, Kirker-Head C (April 2006). "Mesenchymal stem cells and bone regeneration". Vet Surg. 35 (3): 232-42. doi:10.1111/j. ... Within four weeks of placing the scaffold, newly formed bone begins to integrate with the old bone and within 32 weeks, full ... While it is thought that bone-marrow derived stem cells are preferred for bone, cartilage, ligament, and tendon repair, others ...
Cartilage Rothrauff BB, Tuan RS (2014). "Cellular therapy in bone-tendon interface regeneration". Organogenesis. 10 (1): 13-28 ... If hyaline cartilage is torn all the way down to the bone, the blood supply from inside the bone is sometimes enough to start ... It is also present at the tendon bone interface, where there is a transition from soft tendon to uncalcified then calcified ... fibrocartilage before becoming bone. During labor, relaxin loosens the pubic symphysis to aid in delivery, but this can lead to ...
Regeneration of the ventricular myocardium in amphibians. Becker RO, Chapin S, Sherry R. Nature. 1974 Mar 8;248(444):145-7. ... Ultimately, however, the use of electrotherapy for increasing bone healing has not been shown to be effective. Becker believed ... Electrical stimulation of partial limb regeneration in mammals. Becker RO, Spadaro JA. Bull N Y Acad Med. 1972 May;48(4):627-41 ... Mollon B, da Silva V, Busse JW, Einhorn TA, Bhandari M (November 2008). "Electrical stimulation for long-bone fracture-healing ...
2007 DPSC 1st animal studies begin for bone regeneration. 2007 DPSC 1st animal studies begin for dental end uses. 2008 DPSC 1st ... 2008 DPSC 1st advanced animal study for bone grafting announced. Reconstruction of large size cranial bone defects in rats. ... A Promising Tool for Bone Regeneration". Stem Cell Reviews. 4 (1): 21-6. doi:10.1007/s12015-008-9013-5. PMID 18300003. Stem ... tissue Myocytes to repair muscle Osteocytes to generate bone Chondrocytes to generate cartilage Adipocytes to generate fat Bone ...
The material is used to stimulate natural bone regeneration. A clinical study of this technique detailed all patients within ... It is inserted during a sinus lift or augmentation and used to increase the amount of bone to support dental implants. Implants ... It also showed vertical bone gain in all subjects. Numerous different types of material have been used as sinus implants during ... Implants can be in conjunction with sinus surgery to treat chronic sinusitis and also in sinus augmentation to increase bone ...
For example, 74 young Polish women were subjected to medical experiments on bone and muscle transplantation, nerve regeneration ... and Nerve Regeneration and Bone Transplantation Experiments". Doctors From Hell: The Horrific Account Of Nazi Experiments On ... 30-70, ISBN 8385047018 Ken McVay (1998), How many people died at Auschwitz?, The Nizkor Project Vivien Spitz (2005). "Bone, ...
1998). "Muscle regeneration by bone marrow-derived myogenic progenitors". Science. 279 (5356): 528-530. Bibcode:1998Sci... ... Bone Marrow Transplantation 40:609-619. Borlongan CV, Lind JG, Dillon-Carter O, Yu G, Hadman M, Cheng C, Carroll J, Hess DC, et ... Chen J, Li Y, Katakowski M, Chen X, Wang L, Lu D, Lu M, Gautam SC, Chopp M (2003). "Intravenous bone marrow stromal cell ... Dharmasaroja P (2008). "Bone marrow-derived mesenchymal stem cells for the treatment of ischemic stroke". Journal of Clinical ...
Part II: Degeneration and Osteoarthrosis, Repair, Regeneration, and Transplantation". J Bone Joint Surg Am. 79 (4): 612-32. doi ... The hypothesis was that harvesting a mixture of articular cartilage and cancellous bone would combine pluripotent cells of the ... Articular cartilage is a connective tissue overlying the ends of bones that provides smooth joint surfaces. Healthy cartilage ... Current practice and future development". The Journal of Bone and Joint Surgery. American Volume. 76 (9): 1405-18. PMID 8077274 ...
"Autologous bone-marrow stem-cell transplantation for myocardial regeneration". The Lancet. 361 (9351): 45-46. doi:10.1016/S0140 ...
However, this regeneration was not observed when the injected population of cells was devoid of stem cells, which strongly ... Various stem cell lineages have been shown to be able to differentiate into cardiomyocytes, including bone marrow stem cells. ... For example, in one study, researchers transplanted bone marrow cells, which included a population of stem cells, adjacent to ... Orlic D, Hill JM, Arai AE (December 2002). "Stem cells for myocardial regeneration". Circ Res. 91 (12): 1092-102. doi:10.1161/ ...
... siRNA in Bone Regeneration". Journal of Bone and Mineral Research. 31 (3): 475-87. doi:10.1002/jbmr.2816. PMID 26890411. ...
A meniscus transplant or meniscal transplant is a transplant of the meniscus of the knee, which separates the thigh bone (femur ... Stone, KR; Steadman, JR; Rodkey, WG; Li, ST (Dec 1997). "Regeneration of meniscal cartilage with use of a collagen scaffold. ... Some surgeons leave the allograft anchored to its bony attachments and fix these bone bridges or plugs into size matched slots ... A thirty-year follow-up". The Journal of Bone and Joint Surgery. British Volume. 82 (2): 217-21. PMID 10755429. Rockborn, P; ...
"Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix". Biomaterials. 31 (23): 6004. doi:10.1016/j. ... with potential applications in bone and cartilage regeneration, angiogenesis for ischemia or peripheral artery disease, cancer ... "Supramolecular design of self-assembling nanofibers for cartilage regeneration". PNAS. 107 (8): 3293. doi:10.1073/pnas. ...
Osteoporotic bone marrow defect • Our Lady of Fatima University • Outer enamel epithelium • Painless Parker • Pakistan Medical ... Tooth regeneration • Tooth squeeze • Tooth Tunes • Toothache • Toothbrush • Toothpaste • Toothpick • Torus mandibularis • Torus ... palatinus • Traumatic bone cyst • Traumatic neuroma • Treatment of knocked-out (avulsed) teeth • Trench mouth • Treponema ...
October 2005). "Meniscal regeneration using tissue engineering with a scaffold derived from a rat meniscus and mesenchymal ... Osteoarthritis is a common condition of cartilage failure that can lead to limited range of motion, bone damage and invariably ... bone can be exposed in the joint. Some additional examples of cartilage failure mechanisms include cellular matrix linkage ... "Articular cartilage regeneration with autologous peripheral blood progenitor cells and hyaluronic Acid after arthroscopic ...
1996) 4. Established the Laminar Air Flow Room and the Bone Marrow Transplantation Center. (1995) The hospital is accessible ... neural regeneration and repair, and epilepsy research and patient care of the nation. 3. Established National PET/Cyclotron ...
... can improve existing factors of surgery, including recovery times, foreign body implantation, regeneration, and bone ... Tissue Regeneration - Tissue regeneration can help create better drug formulations, decrease human and animal lab testing, and ... Two of the most common types of bone grafts used today are allografts, grafts made from a deceased donor's bone, and autografts ... In today's surgical repairs, bone grafts or replacement bones are not as precise and accurate because they are not made ...
Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible. In: Journal of ... Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible. Journal of ... Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible. / Nagashima, ... title = "Bone regeneration and docking site healing after bone transport distraction osteogenesis in the canine mandible", ...
Regeneration of functional sweat gland-like structures by transplanted differentiated bone marrow mesenchymal stem cells. Wound ... Bone marrow. Mesoblast. CD73, CD44. CD105, CD90. CD45,CD34,. Low. High. Safe. Low. Low. Not easy to obtain. Can harm the donor ... Bone Marrow Transplant 1995; 16:557-564 45. Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WW, Gordon PL, Neel M, Sussman M, ... Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 2005; 33(2): 145-152 doi: ...
... and different types of bone substitutes with or without guided tissue regeneration (GTR) has been proposed as a modality to ... and different types of bone substitutes with or without guided tissue regeneration (GTR) has been proposed as a modality to ... and different types of bone substitutes with or without guided tissue regeneration (GTR) has been proposed as a modality to ... and different types of bone substitutes with or without guided tissue regeneration (GTR) has been proposed as a modality to ...
Often, when a patient loses teeth due to trauma or disease, bone loss ensues that makes it difficult or impossible to use ... Tags: Bone, Bone Graft, Dental Implant, Dentures, Implants, Platelets, Surgery, Teeth, Trauma, Wound, Wound Healing ... Often titanium mesh is used as a tent over the bone graft to support the grafts shape and volume while the new bone grows. ... To combat this problem, bone grafting, a surgical procedure that replaces bone, is often used to serve as a support for dental ...
The range of biomimetic approaches to promote bone growth that are at the core of current bone healing therapies need to more ... Designing bone healing therapies that better mimic regeneration. Mary Ann Liebert, Inc./Genetic Engineering News ... The range of biomimetic approaches to promote bone growth that are at the core of current bone healing therapies need to more ... designing-bone-healing-therapies-that-better-mimic-regeneration/. 2109/. Related Journal Article. http://dx.. doi.. org/. 10. ...
Guided bone regeneration is a technique used in dentistry to rebuild part of the bone in the jaw before performing implants and ... Guided bone regeneration is used in dentistry to rebuild part of the bone in the jaw. Chronic dental disease and tooth loss ... Guided bone regeneration (GBR) is a technique used in dentistry to rebuild part of the bone in the jaw, if necessary, before ... The process of guided bone regeneration can be monitored with periodic physical exams and X-rays to check on bone growth. ...
... is a procedure that has been used in dental surgery for over 20 years for the treatment of bone loss. It involves placing bone ... Guided bone regeneration (GBR) is a procedure that has been used in dental surgery for over 20 years for the treatment of bone ... Real-time-guided bone regeneration around standardized critical size calvarial defects using bone marrow-derived mesenchymal ... The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and ...
... circuit between miRNAs and osteogenic homeostasis is of great value for artificial skeletal regeneration for severe bone ... Osteogenesis originates from mesenchymal stem cells (MSCs) differentiating into mature osteoblasts and each period of bone ... with diverse osteo-related genes and endeavor to sketch the contours of potential manipulations of miRNA-modulated bone repair. ... which have been reported to play a crucial role in maintaining bone development and metabolism. ...
a-c, a′-c′ Bone regeneration after synovectomy of the 5th metatarsophalangeal joint of the left foot. The left panel shows the ... Bone and cartilage regeneration in rheumatology clinical practice. The results described above clearly show that not only ... The 2005 article by Ikari and Momohara clearly showed that methotrexate can induce bone regeneration [29], and many ... When the joint has the ability to regenerate the destroyed bone and/or articular cartilage, self-regeneration should occur ...
"Effects of Choukrouns platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in ... Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation. Qi Li,1,2 Shuang Pan,3 Smit J. ... R. Dimitriou, E. Jones, D. McGonagle, and P. V. Giannoudis, "Bone regeneration: current concepts and future directions," BMC ... Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift," Oral Surgery, Oral Medicine, Oral ...
... in this study we aimed to further characterize bone regeneration induced by corticocancellous porcine bone, porcine bone blocks ... said, it shows comparable bone healing potential and bone blood supply [15]. Pobloth evidenced that sheep bone, however, ... Bone Regeneration in Iliac Crestal Defects: An Experimental Study on Sheep. Antonio Scarano,1 Felice Lorusso,2 Lorenzo Ravera,2 ... osteoblasts derived from the periosteum and/or adjacent bone and/or bone marrow) to the bone defect site and exclusion of cells ...
Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors Message Subject. (Your Name) has forwarded a page to you from ... Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors. By Giuliana Ferrari, Gabriella Cusella-, De Angelis, Marcello ... Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors. By Giuliana Ferrari, Gabriella Cusella-, De Angelis, Marcello ... Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into ...
Usually, bone fractures do not heal by a direct bridging of the fracture gap with newly formed bone (primary bone healing). ... Bone is a multifunctional organ, a biological material and is able to fully restore bone fractures without leaving a scar. ... However, in about 10% of the bone fractures, healing does not lead to a successful reunion of the broken bone ends. Intensive ... Im menschlichen Körper kommt es nach einem Bruch zu einer vollständigen Regeneration des Knochens, ohne dass eine Narbe nach ...
Bone Quality and Quantity Following Guided Bone Regeneration. Official Title Examining Bone Quantity and Quality Following ... Bone Quality and Quantity Following Guided Bone Regeneration. This study has been completed. ... a routine alveolar bone augmentation is done to enable a dental implant installation at this site.Guided bone regeneration (GBR ... The bone substitute provides a scaffold to alveolar regeneration by the hosts osteoblasts while the membrane prevents unwanted ...
Bone Repair and Regeneration Although most bone fractures have remarkable reparative potential to heal common injuries on their ... The scans of the healing allograft (left) are segmented to separate the allograft bone (middle) from the new bone that formed ( ... differentiation and/or remodeling signals into the injury site to facilitate bone regeneration. Based on the remarkable success ... Pictured Left: Schematic model of strategies that combine stem cell technology and gene therapy to tissue engineer bone as ...
Cartilage Soak Bone, Flesh & Cartilage tea Ingredients: Comfrey root*, White Oak bark*, Gravel root+, Black Walnut Hull+, ... Formally called Bone, Flesh & Cartilage tea) Ingredients (*Organic, +Wildcrafted): Comfrey root*, White Oak bark*, Gravel root+ ...
... have emerged as promising building blocks for constructing bone scaffolds. In this study, fibrous scaffolds (PGFS) were ... Preparation and characterization of fibrous chitosan-glued phosphate glass fiber scaffolds for bone regeneration. ... Derubeis AR, Cancedda R. Bone marrow stromal cells (BMSCs) in bone engineering: limitations and recent advances. Ann Biomed Eng ... These results suggest that PGFS could be promising scaffolds for bone regeneration applications. ...
bone screw kit. Hu-Friedy. W&H Motors. Bien-Air Motors. research. Laser-Lok abstracts. dental implant abstracts. AlloDerm RTM ...
... has warned Parcell Laboratories that it mischaracterized its stem cell-based bone regeneration product as a human cell, tissue ... FDA challenges classification of stem cell-based bone regeneration product Shook Hardy & Bacon LLP ... has warned Parcell Laboratories that it mischaracterized its stem cell-based bone regeneration product as a human cell, tissue ...
Without new periodontal ligament formation, new attachment and bone regeneration is impossible. In the past, the difficulty had ... Guided Tissue Regeneration. Periodontal tissue regeneration was ingeniously solved with the advent of sub-gingival (sub-under, ... Innovations in regeneration. The last two decades have seen an explosion of knowledge and new techniques to regenerate ... Regeneration techniques were already understood from wound healing studies and knowledge of the cell types that "coded" for new ...
The focus of the research area Bone and Tissue Regeneration is to define the molecular and cellular mechanisms of bone ... regeneration as well as the interactions of immune and cancer cells within bone regeneration. Elucidated key factors are tested ... from bone marrow and cancellous bone for musculoskeletal tissue regeneration.. *Understanding of osteocyte biology, as these ... This will provide the basis for the development of targeted and better-defined therapeutic strategies for bone/cartilage loss ...
According to the invention the membrane (4, 4′, 24, 35) has, on its surface facing the tissue or bone, means (16) for the ... These means (16) for the biological anchoring of tissue cells are specifically bone cells, protein molecules and/or osteoblasts ... specifically a vital bone (2, 22, 38, 39). Means (9, 5, 6, 25, 36) are additionally provided whereby the membrane (4, 4′, 24, ... 35) is movable for the regeneration with a certain pulling force and speed. ...
Bone Regeneration by Haim Tal - free book at E-Books Directory. You can download the book or read it online. It is made freely ... There are several modalities of bone regeneration including tissue engineering, guided bone regeneration, distraction ... This book concentrates on such procedures that may well be counted among the recent outstanding breakthroughs in bone ...
... its utility in bone regeneration has been suggested. Here, we evaluated the effect of CCN2 on the regeneration of an ... Promotion of Bone Regeneration by CCN2 Incorporated into Gelatin Hydrogel * * Kikuchi Takeshi ... These results confirm the utility of CCN2 in the regeneration of intractable bone defects in vivo when the factor is ... Finally, distinct enhancement of bone regeneration was observed 3 weeks after the application of the complex. ...
... sensor technology and cartilage scaffolding systems as major developments in the use of engineered cartilage for bone and joint ... Renal Osteodystrophy / Mineral Bone Disorder. Renal Osteodystrophy which is referred to as Mineral Bone Disorder is a result of ... Researchers: Cartilage Regeneration for Bone and Joint Repair is Closer for Patients. ... Infantile Cortical Hyperostosis is a disease of unknown cause, where bizarre thickening of the cortical bones of infants is the ...
  • Studies are underway to identify when the regenerate properties compare with normal bone and to identify methods to augment bone union at the docking site. (elsevier.com)
  • In a site with a lack of bone GBR is a surgical procedure that provides an augmentation in terms of volume for the insertion of dental implants. (hindawi.com)
  • One technique of ridge augmentation is Guided Bone Regeneration (GBR). (hindawi.com)
  • In such cases, a routine alveolar bone augmentation is done to enable a dental implant installation at this site.Guided bone regeneration (GBR) is a widely used technique used to augment edentulus bone ridges. (clinicaltrials.gov)
  • In cases where augmentation materials used are autografts or allografts the bone density is quite low and resorption of the grafted site in these cases can reach up to 30% of original volume. (wikipedia.org)
  • Chapters cover developing treatment algorithms for tooth retention or implant placemen, maximizing treatment results with guided bone regeneration therapy, considerations for esthetic treatment options, and augmentation of the posterior maxilla. (thefreedictionary.com)
  • The combination of guided bone regeneration (GBR) and bone augmentation is an established procedure to restore the bone. (diva-portal.org)
  • Guided Bone Regeneration and Ridge Augmentation have become routine procedures to enhance the functional, biological and aesthetic outcome of dental implants. (ucla.edu)
  • A common challenge of augmentation protocols, however, especially when bone grafting with a granules or even most putty systems, is the possibility of migration and/or inadequate space maintenance, which ultimately decreases the possibilities of achieving the desired bone volume. (dentalxp.com)
  • We concluded that LM-CA bone cement can be used as a bioactive bone graft material due to ability of bonding to the existing bone and CA-PMMA can be used as a graft material for augmentation of bone-volume due to dimensional stability. (scientific.net)
  • Brunel G, Brocard D, Duffort JF, Jacquet E, Justumus P, Simonet T, Benque E: Bioabsorbable materials for guided bone regeneration prior to implant placement and 7-year followup: report of 14 cases. (scientific.net)
  • Whether used to replace autogenous bone entirely or expand autogenous grafts, bone substitute materials (BSM) must be effective for time-delayed procedures before dental implant insertion and for recipient site optimization at the time of implant placement (simultaneous procedures). (dentalproductshopper.com)
  • This procedure yields favorable results for bone formation, implant placement, and patient satisfaction. (quintpub.com)
  • Bone regeneration is the process whereby bone is able to (scarlessly) repair itself from trauma, such as fractures or implant placement. (royalsocietypublishing.org)
  • The current paper focuses on the ( in silico ) biology of the bone regeneration process, taking place after bone traumata such as fractures or implant placement. (royalsocietypublishing.org)
  • Various grafting materials have been successfully utilized to increase bone volume before or during implant placement. (dentalxp.com)
  • How to preserve a ridge utilizing a Calcium-Phosphosilicate bone putty as well as utilization in sinus grafting and immediate implant placement. (dentalxp.com)
  • This treatment offers an alternative to ridge splitting procedures, demonstrating the molar implant placement and simultaneous guided bone regeneration of a 56-year-old woman's atrophic left mandible. (bicon.com)
  • Any bone obtained from a patient for their own surgery is also very safe and offers the best type of bone for implant placement. (facialart.com)
  • New Rochelle, NY, Feb.15, 2017 -- The range of biomimetic approaches to promote bone growth that are at the core of current bone healing therapies need to more closely emulate natural regenerative mechanisms. (eurekalert.org)
  • In the recent times, the global market for Global bone regeneration material market research report 2017 has surfaced as one of the most promising markets in the pharmaceutical industry, thanks to the significant rise in research and development activities by leading vendors of Global bone regeneration material market research report 2017 across the world. (qyresearchreports.com)
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  • The research report on the Global bone regeneration material market research report 2017 is an analytical study which comprehensively analyzes the competitive framework of this market. (qyresearchreports.com)
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  • The study begins with a detailed overview of the market for Global bone regeneration material market research report 2017, including the definition, classification, and industry chain structure of Global bone regeneration material market research report 2017, and move forward to cover every aspect of this market, counting several criteria based on which the market is classified. (qyresearchreports.com)
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  • 2017. "Composites of Gellan Gum Hydrogel Enzymatically Mineralized with Calcium-zinc Phosphate for Bone Regeneration with Antibacterial Activity. (ugent.be)
  • Transplantation of genetically marked bone marrow into immunodeficient mice revealed that marrow-derived cells migrate into areas of induced muscle degeneration, undergo myogenic differentiation, and participate in the regeneration of the damaged fibers. (sciencemag.org)
  • Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney. (nih.gov)
  • In bone marrow-derived MCs (BMMCs), Ag stimulation caused intense phosp. (medworm.com)
  • At the cellular level, the pharmaceutical effect of NMP was confirmed, in particular, in combination with BMP-2, as NMP increased early and late markers for maturation of preosteoblasts and human bone marrow derived stem cells in vitro. (uzh.ch)
  • Heikkilä JT, Kukkonen J, Aho AJ, Moisander S, Kyyrönen T, Mattila K. Bioactive glass granules: a suitable bone substitute material in the operative treatment of depressed lateral tibial plateau fractures: A prospective, randomized 1 year follow-up study. (springer.com)
  • Bioactive glass is more reactive than these materials, and promotes bone regeneration by releasing silica ions. (dentalproductshopper.com)
  • Perhaps this would be a good indication for a bioactive modifier incorporated into the bone graft like PRGF or rhBMP? (dentalxp.com)
  • Researchers have designed a 3D-printed porous scaffold for use in reconstructing ruptured anterior cruciate ligament in the knee and engineered it to deliver a human bone-promoting protein over an extended period of time to improve bone regeneration. (medindia.net)
  • Our research suggests that enhancing human bone repair or even inducing bone regeneration isn't a ridiculous idea," he said. (healthcanal.com)
  • Bone-graft material may be in form of calcified granules such as mineralized freeze dried human bone, bovine bone, or synthetic materials provided in single pre-packed bottles. (facialart.com)
  • Experimental studies have also provided accumulating evidences that peripheral nerve fibers not only are important in normal bone homeostasis and skeletal growth 3 , but also have influence on repair mechanism of bone fracture 4 . (medsci.org)
  • Description Bone loss and skeletal deficiencies due to traumatic injury or disease are major problems worldwide. (rutgers.edu)
  • Moreover, antibodies against sclerostin have been evaluated in a bone defect model in diabetic rats and showed superior effects compared to the osteo-anabolic hormone PTH. (crt-dresden.de)
  • The rat calvarial bone defect model has been well-performed in previous studies by our group (e.g. 3863, 4903, 6483, 6866, 12936). (mattilsynet.no)
  • The bone regeneration and healing effect of formononetin was evaluated in a cortical bone defect model that predominantly heals by intramembranous ossification. (cambridge.org)
  • PARTICULATE AUTOGRAFT OSSIX ® GRAFT Particulate Allograft products consist of cortical bone matrix and may be used in a variety of reconstructive, periodontal, and oral maxillofacial procedures. (orapharma.com)
  • A particulate allograft that consists of cortical bone matrix, and may be used in a variety of reconstructive, periodontal, and oral maxillofacial procedures. (orapharma.com)
  • Morphometric and physical characterization of double cortical porosity - The bone is considered here as a medium with 2 porosity levels: vascular (Ø~100 µm) and lacuno-canalicular (Ø~100nm - 10 µm). (esbiomech.org)
  • Thanks to these investigation ways, the aim is to assess LCN permeability of the cortical bone which will feed the digital model. (esbiomech.org)
  • The crestal cortical bone is being shaped with a 2.5mm latch reamer at high speed with copious sterile irrigation. (bicon.com)
  • This technology is transformative because it will be the first synthetic bone graft to contain both trabecular and cortical bone structures and be designed for vascularized bone growth and load-bearing applications. (rutgers.edu)
  • Dr Leandro Bolzoni from the University of Waikato's School of Engineering has been awarded a Health Research Council explorer grant worth $150,000 to research bone regeneration using alternative synthetic materials for joint replacements. (waikato.ac.nz)
  • The causes of a bone fracture can be very different in nature: trauma, stress (fatigue fracture), idiopathic or congenital bone diseases and disorders, bone metastases, therapeutic treatments such as prostheses implant, bone lengthening or tumor resection. (esbiomech.org)
  • Although the field of bone regeneration has made great advances in recent decades, coupling personalized diagnosis and optimal treatment of bone fracture remains a challenge due to the large number of variables to be taken into account. (esbiomech.org)
  • To optimize bone regeneration, Pobloth and colleagues modified titanium-mesh scaffold designs to provide specific strains and stresses within the fracture environment. (sciencemag.org)
  • In conclusion, the findings suggest that a lineage of bone-producing cell, which are specified in embryonic somites, are maintained throughout the animal lives as progenitor cells for bone regeneration and also for bone maintenance (Figure 3). (titech.ac.jp)
  • The researchers found that cell-to-cell signaling mediated by the Wnt pathway helps existing mature bone cells become progenitor cells after fin amputation. (healthcanal.com)
  • Local Wnt production at the tip of the regrowing fin then maintains a pool of dividing bone progenitor cells until the fin is fully replaced. (healthcanal.com)
  • The job of second pathway, BMP, is to convert the progenitor cells back into mature bone that forms the characteristic bony rays of a fish's fins. (healthcanal.com)
  • Proliferation of small hepatocyte like progenitor cells, appearing at 6 months, may suggest that in the presence of refrorsine these cells compromise bone marrow cell engraftment in the mouse. (ebscohost.com)
  • Oral and intravenous medications affect the whole body, but to promote joint regeneration in a particular joint, two potent options are intra-articular steroid injection and synovectomy. (springer.com)
  • Liu Y, Lian Q, He J et al (2011) Study on the microstructure of human articular cartilage/bone Interface. (springer.com)
  • In parallel with studies that focus on understanding biological processes in response to USBR (from cell to organ), there are many works on bone mechanotransduction. (esbiomech.org)
  • These models were followed by the development of bioregulatory models where mechanics was neglected and regeneration was regulated only by biological stimuli such as growth factors. (royalsocietypublishing.org)
  • It starts with a summary of the most important biological processes taking place during bone regeneration, and subsequently discusses the modelling efforts that have been undertaken in this research domain hitherto. (royalsocietypublishing.org)
  • Calcium phosphate-based coatings and nanocomposites offer unique solutions towards producing scaffolds with suitable physical, mechanical and biological properties for bone regeneration. (uwo.ca)
  • Our research group deals primarily with biological aspects of bone healing. (charite.de)
  • In addition to histological investigations of the healing processes (Fig.1) and the visualization of new bone and vessel formation using micro-computer tomography and contrast agent (Fig.2), the molecular analysis of biological processes are also a focus of our research. (charite.de)
  • In a study, researchers at King Saud University in Riyadh, Saudi Arabia, showed how 3D micro-CT could help advance the study of GBR, by more precisely revealing the first instance of new bone formation, and how it could be used to test alternative types of bone graft material. (news-medical.net)
  • To evaluate the different potentially regenerating biomaterials, a histological analysis to find the percentage of the bone fill of the defect (partial or complete) and the percentage of the contact between the newly formed bone and the surface of the implant is necessary. (hindawi.com)
  • Patients answering the inclusion but not the exclusion criteria will go through an alveolar computerized tomography (C.T) done routinely before inserting dental implants.At the day of Dental implantation - residual bone left from the site of implantation (after preparing the site with a trephine bur) will be taken to a histological analysis. (clinicaltrials.gov)
  • The histological investigation showed that the bone trabeculae were dis-arrayed containing dispersed cartilage cells on the denervation side, whereas the bone trabeculae were orderly with rich blood vessels and no cartilage cell on the control side. (medsci.org)
  • After local injection of EPC-Exos into the distraction gaps after distraction, the therapeutic effects of EPC-Exos on bone regeneration and angiogenesis were assessed via X-ray, micro-computed tomography (micro-CT), and biomechanical and histological analyses. (izon.com)
  • X-ray, micro-CT, and histological analyses revealed that bone regeneration was markedly accelerated in rats treated with EPC-Exos. (izon.com)
  • Therefore, further characterization of polyphosphate function may be pertinent to the regulation of pathological mineralization as well as the promotion of bone regeneration. (omicsonline.org)
  • Finally, distinct enhancement of bone regeneration was observed 3 weeks after the application of the complex. (nii.ac.jp)
  • Their yield stress and modulus were ~0.38 and ~2.84 MPa, respectively, with the strength being higher than the lower bound of the compressive strength of cancellous bone. (springer.com)
  • Bacterin OsteoSponge block is a novel, cancellous demineralized bone matrix from curasan. (dentalproductshopper.com)
  • Bone turnover was assessed indirectly by bone histomorphometry using the following abbreviations: Mineral Apposition Rate (MAR): Distance between 2 fluorochrome markers that comprise a double label on the surfaces of cancellous bone measured at an average of 4 equally-spaced sites per double label. (clinicaltrials.gov)
  • Oc.S/BS cancellous: Osteoclast suface divided by bone surface. (clinicaltrials.gov)
  • Osteoclastic surface as percent of total bone surface in cancellous bone. (clinicaltrials.gov)
  • Percent cancellous bone perimeter with osteoclasts (large, multinuclear, TRAP positive cells). (clinicaltrials.gov)
  • OS/BS cancellous: Osteoid surface divided by bone surface. (clinicaltrials.gov)
  • Percentage of cancellous bone perimeter covered with osteoid. (clinicaltrials.gov)
  • 1 - 3 Cancellous bone of the iliac area is mainly used as donor material. (medsci.org)
  • The risk of complications in the donor area increases accordingly with increased need to use cancellous bone from both sides of iliac area. (medsci.org)
  • They created a virtual 3D model of the patient's mouth and bony defect, then, with a computer program, determined the correct position and placement of the bone graft based on the desired location of replacement teeth. (news-medical.net)
  • During surgery, the authors ensured the proper placement of the titanium mesh and bone graft with a positioning jig fabricated from a clear plastic mold that used the existing teeth to hold the mesh in place while it was being secured. (news-medical.net)
  • The researchers carried out their experiments in the skull bones of rats, which are thought to act as a model for the bones of the oral and maxillofacial region in humans. (news-medical.net)
  • In this study, primary uBMSCs were isolated from femoral bone marrow of Lewis rats. (aanem.org)
  • Forty Wistar Albino rats allocated into 4 experimental groups: platelet-rich fibrin (PRF) group, noncross-linked hyaluronic acid gel (HA) group, demineralized bone matrix in putty form (DBM) group, and control group. (ovid.com)
  • This study aimed to investigate whether EPC-Exos promote bone regeneration during DO in rats. (izon.com)
  • Guided bone regeneration (GBR) is a technique used in dentistry to rebuild part of the bone in the jaw, if necessary, before performing implants and fitting other dental appliances. (wisegeek.com)
  • I confess to having a particular interest in periodontal treatment, implants, and bone grafting. (dentalproductshopper.com)
  • Bone insufficiency remains a major challenge for bone-anchored implants. (diva-portal.org)
  • Currently metallic implants are most commonly used, but due to being a much stiffer material than human bones, the implants causes osteoporosis and eventual loosening of the implant. (waikato.ac.nz)
  • Guided bone regeneration procedures typically require follow-up X-rays to monitor progress. (wisegeek.com)
  • The U.S. Food and Drug Administration allows for the use of recombinant BMP to encourage bone-growth following some surgical procedures. (healthcanal.com)
  • In the U.S., approximately 500,000 bone-grafting procedures are performed annually. (rutgers.edu)
  • μ CT analysis showed that formononetin promoted bone healing at days 10 and 21 and the healing effect observed was significantly better than in Ovx mice and equal to PTH treatment in many aspects. (cambridge.org)
  • Formononetin also significantly enhanced bone regeneration as assessed by calcein-labelling studies. (cambridge.org)
  • The combination of NELL-1 and BMP2 resulted in improved safety and efficacy of bone regeneration in animal models - and may, one day, offer patients significantly better bone healing. (ucla.edu)
  • Previous and present studies demonstrate a strong rationale for combining NELL-1 with BMP2 to significantly improve the safety and efficacy of current bone regeneration options. (ucla.edu)
  • Longest bone trabecula significantly increased in DBM group compared with HA group (P (ovid.com)