Tumors or cancer located in bone tissue or specific BONES.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Bone loss due to osteoclastic activity.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
Diseases of BONES.
Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
An acute infection of the skin caused by species of STREPTOCOCCUS. This disease most frequently affects infants, young children, and the elderly. Characteristics include pink-to-red lesions that spread rapidly and are warm to the touch. The commonest site of involvement is the face.
Time period from 1801 through 1900 of the common era.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A disorder caused by hemizygous microdeletion of about 28 genes on chromosome 7q11.23, including the ELASTIN gene. Clinical manifestations include SUPRAVALVULAR AORTIC STENOSIS; MENTAL RETARDATION; elfin facies; impaired visuospatial constructive abilities; and transient HYPERCALCEMIA in infancy. The condition affects both sexes, with onset at birth or in early infancy.
Graphical representation of a statistical model containing scales for calculating the prognostic weight of a value for each individual variable. Nomograms are instruments that can be used to predict outcomes using specific clinical parameters. They use ALGORITHMS that incorporate several variables to calculate the predicted probability that a patient will achieve a particular clinical endpoint.
I'm sorry for any confusion, but "Connecticut" is a state located in the northeastern region of the United States and does not have a medical definition. If you have any questions related to medicine or health, I would be happy to try to help answer those!
A species of gram-positive, coccoid bacteria isolated from skin lesions, blood, inflammatory exudates, and the upper respiratory tract of humans. It is a group A hemolytic Streptococcus that can cause SCARLET FEVER and RHEUMATIC FEVER.
Branch of medicine concerned with the prevention and control of disease and disability, and the promotion of physical and mental health of the population on the international, national, state, or municipal level.
A subdiscipline of human genetics which entails the reliable prediction of certain human disorders as a function of the lineage and/or genetic makeup of an individual or of any two parents or potential parents.
The systematic study of the complete DNA sequences (GENOME) of organisms.
Decisions, usually developed by government policymakers, for determining present and future objectives pertaining to the health care system.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
The activities and endeavors of the public health services in a community on any level.
The integration of epidemiologic, sociological, economic, and other analytic sciences in the study of health services. Health services research is usually concerned with relationships between need, demand, supply, use, and outcome of health services. The aim of the research is evaluation, particularly in terms of structure, process, output, and outcome. (From Last, Dictionary of Epidemiology, 2d ed)

Relative efficacy of 32P and 89Sr in palliation in skeletal metastases. (1/5419)

32p and 89Sr have been shown to produce significant pain relief in patients with skeletal metastases from advanced cancer. Clinically significant pancytopenia has not been reported in doses up to 12 mCi (444 MBq) of either radionuclide. To date, no reports comparing the relative efficacy and toxicity of the two radionuclides in comparable patient populations have been available. Although a cure has not been reported, both treatments have achieved substantial pain relief. However, several studies have used semiquantitative measures such as "slight," "fair," "partial" and "dramatic" responses, which lend themselves to subjective bias. This report examines the responses to treatment with 32P or 89Sr by attempting a quantification of pain relief and quality of life using the patients as their own controls and compares toxicity in terms of hematological parameters. METHODS: Thirty-one patients with skeletal metastases were treated for pain relief with either 32P (16 patients) or 89Sr (15 patients). Inclusion criteria were pain from bone scan-positive sites above a subjective score of 5 of 10 despite analgesic therapy with narcotic or non-narcotic medication, limitation of movement related to the performance of routine daily activity and a predicted life expectancy of at least 4 mo. The patients had not had chemotherapy or radiotherapy during the previous 6 wk and had normal serum creatinine, white cell and platelet counts. 32P was given orally as a 12 mCi dose, and 89Sr was given intravenously as a 4 mCi (148 MBq) dose. The patients were monitored for 4 mo. RESULTS: Complete absence of pain was seen in 7 of 16 patients who were given 32P and in 7 of 15 patients who were given 89Sr. Pain scores fell by at least 50% of the pretreatment score in 14 of 16 patients who were given 32P and 14 of 15 patients who were given 89Sr. Mean duration of pain relief was 9.6 wk with 32P and 10 wk with 89Sr. Analgesic scores fell along with the drop in pain scores. A fall in total white cell, absolute granulocyte and platelet counts occurred in all patients. Subnormal values of white cells and platelets were seen in 5 and 7 patients, respectively, with 32P, and in 0 and 4 patients, respectively, after 89Sr therapy. The decrease in platelet count (but not absolute granulocyte count) was statistically significant when 32P patients were compared with 89Sr patients. However, in no instance did the fall in blood counts require treatment. Absolute granulocyte counts did not fall below 1000 in any patient. There was no significant difference between the two treatments in terms of either efficacy or toxicity. CONCLUSION: No justification has been found in this study for the recommendation of 89Sr over the considerably less expensive oral 32P for the palliation of skeletal pain from metastases of advanced cancer.  (+info)

A fluorescent orthotopic bone metastasis model of human prostate cancer. (2/5419)

Here, we report a fluorescent spontaneous bone metastatic model of human prostate cancer developed by surgical orthotopic implantation of green fluorescent protein (GFP)-expressing prostate cancer tissue. Human prostate cancer PC-3 cells were transduced with the pLEIN expression retroviral vector containing the enhanced GFP and neomycin resistance genes. Stable GFP high-expression PC-3 clones were selected in vitro with G418, which were then combined and injected s.c. in nude mice. For metastasis studies, fragments of a single highly fluorescent s.c. growing tumor were implanted by surgical orthotopic implantation in the prostate of a series of nude mice. Subsequent micrometastases and metastases were visualized by GFP fluorescence throughout the skeleton, including the skull, rib, pelvis, femur, and tibia The central nervous system, including the brain and spinal cord, was also involved with tumor, as visualized by GFP fluorescence. Systemic organs, including the lung, plural membrane, liver, kidney, and adrenal gland, also had fluorescent metastases. The metastasis pattern in this model reflects the bone and other metastatic sites of human prostate cancer. Thus, this model should be very useful for the study and development of treatment for metastatic androgen-independent prostate cancer.  (+info)

Ibandronate reduces osteolytic lesions but not tumor burden in a murine model of myeloma bone disease. (3/5419)

We determined the effects of the potent bisphosphonate ibandronate in a murine model of human myeloma bone disease. In this model, bone lesions typical of the human disease develop in mice following inoculation of myeloma cells via the tail vein. Treatment with ibandronate (4 micrograms per mouse per day) significantly reduced the occurrence of osteolytic bone lesions in myeloma-bearing mice. However, ibandronate did not prevent the mice from developing hindlimb paralysis and did not produce a detectable effect on survival. There was no significant effect of ibandronate on total myeloma cell burden, as assessed by morphometric measurements of myeloma cells in the bone marrow, liver, and spleen, or by measurement of serum IgG2b levels. These results support clinical findings that bisphosphonates may be useful for the treatment of myeloma-associated bone destruction, but suggest that other therapies are also required to reduce tumor growth.  (+info)

Gastrin-releasing peptide receptors in the human prostate: relation to neoplastic transformation. (4/5419)

Bombesin-like peptides such as gastrin-releasing peptide (GRP) have been shown to play a role in cancer as autocrine growth factors that stimulate tumor growth through specific receptors. To search for potential clinical indications for GRP analogues, it is important to identify human tumor types expressing sufficient amounts of the respective receptors. In the present study, we have evaluated the expression of GRP receptors in human nonneoplastic and neoplastic prostate tissues using in vitro receptor autoradiography on tissue sections with 125I-Tyr4-bombesin as radio-ligand. GRP receptors were detected, often in high density, in 30 of 30 invasive prostatic carcinomas and also in 26 of 26 cases of prostatic intraepithelial proliferative lesions, corresponding mostly to prostatic intraepithelial neoplasias. Well-differentiated carcinomas had a higher receptor density than poorly differentiated ones. Bone metastases of androgen-independent prostate cancers were GRP receptor-positive in 4 of 7 cases. Conversely, GRP receptors were identified in only a few hyperplastic prostates and were localized in very low density in glandular tissue and, focally, in some stromal tissue. In all of the cases, the receptors corresponded to the GRP receptor subtype of bombesin receptors, having high affinity for GRP and bombesin and lower affinity for neuromedin B. These data demonstrate a massive GRP receptor overexpression in prostate tissues that are neoplastically transformed or, like prostatic intraepithelial neoplasias, are in the process of malignant transformation. GRP receptors may be markers for early molecular events in prostate carcinogenesis and useful in differentiating prostate hyperplasia from prostate neoplasia Such data may not only be of biological significance but may also provide a molecular basis for potential clinical applications such as GRP-receptor scintigraphy for early tumor diagnosis, radiotherapy with radiolabeled bombesin-like peptide analogues, and chemotherapy with cytotoxic bombesin analogues.  (+info)

Prognostic significance of extent of disease in bone in patients with androgen-independent prostate cancer. (5/5419)

PURPOSE: To evaluate the prognostic significance of a bone scan index (BSI) based on the weighted proportion of tumor involvement in individual bones, in relation to other factors and to survival in patients with androgen-independent prostate cancer. PATIENTS AND METHODS: Baseline radionuclide bone scans were reviewed in 191 assessable patients with androgen-independent disease who were enrolled onto an open, randomized trial of liarozole versus prednisone. The extent of skeletal involvement was assessed by scoring each scan using the BSI and independently according to the number of metastatic lesions. The relationship of the scored bone involvement to other known prognostic factors was explored in single- and multiple-variable analyses. RESULTS: In single-variable analyses, the pretreatment factors found to be associated with survival were age (P = .0446), performance status (P = .0005), baseline prostate-specific antigen (P = .0001), hemoglobin (P = .0001), alkaline phosphatase (P = .0002), AST (P = .0021), lactate dehydrogenase (P = .0001), and treatment (P = .0098). The extent of osseous disease was significant using both the BSI (P = .0001) and the number of lesions present (P = .0001). In multiple-variable proportional hazards analyses, only BSI, age, hemoglobin, lactate dehydrogenase, and treatment arm were associated with survival. When the patient population was divided into three equal groups, with BSI values of < 1.4%, 1.4% to 5.1%, and > 5.1%, median survivals of 18.3, 15.5, and 8.1 months, respectively, were observed (P = .0079). CONCLUSION: The BSI quantifies the extent of skeletal involvement by tumor. It allows the identification of patients with distinct prognoses for stratification in clinical trials. Further study is needed to assess the utility of serial BSI determinations in monitoring treatment effects. The BSI may be particularly useful in the evaluation of agents for which prostate-specific antigen changes do not reflect clinical outcomes accurately.  (+info)

Biochemical markers of bone turnover in breast cancer patients with bone metastases: a preliminary report. (6/5419)

BACKGROUND: Some biochemical markers of bone turnover are expected to reflect the disease activity of metastatic bone tumor. In the present study six biochemical markers were evaluated to determine appropriate markers for the detection of metastatic bone tumors from breast cancer (BC). METHODS: A panel of bone turnover markers was assessed in 11 normocalcemic patients with bone metastases from BC and in 19 BC patients without clinical evidence of bone metastases. Bone formation was investigated by measuring serum bone isoenzyme of alkaline phosphatase (BALP), osteocalcin (OC) and carboxy-terminal propeptide of type I procollagen (PICP): Bone resorption was investigated by measuring serum carboxy-terminal telopeptide of type I collagen (ICTP), fasting urinary pyridinoline (Pyr) and deoxypyridinoline (D-Pyr). RESULTS: PICP was influenced by age and menopausal status. Significant correlations were observed between each of bone turnover markers except between BALP and OC. The mean levels of the six bone turnover markers were higher in patients with bone metastases than in those without them and significance was observed except for OC. The best diagnostic efficiency by receiver-operating characteristic (ROC) analysis was provided by ICTP followed by Pyr or D-Pyr, BALP, PICP and OC and significance was observed between ICTP and OC. Multiple logistic regression analysis adjusted by age revealed that the only significant marker related to bone metastases was ICTP. CONCLUSIONS: Serum ICTP appears to be the leading marker of bone metastases from BC. However, to reveal the clinical usefulness of these markers, further examination will be needed to account for the ease and cost-effectiveness of the measurements.  (+info)

Phase I trial of the combination of daily estramustine phosphate and intermittent docetaxel in patients with metastatic hormone refractory prostate carcinoma. (7/5419)

BACKGROUND: To apply our preclinical findings of cytotoxic synergy with the combination of estramustine phosphate (EP) and docetaxel as the basis of treatment of hormone refractory metastatic prostate cancer in man. To determine the optimal dosage and the toxicities of these two agents for future trials. PATIENTS AND METHODS: Seventeen patients with hormone refractory metastatic prostate cancer who were ambulatory with performance status < or = 2, normal marrow, renal and hepatic function were entered. Prior exposure to EP or a taxane were exclusion factors. EP was given orally at a dose of 14 mg/kg of body weight daily with concurrent docetaxel administered every 21 days as an intravenous infusion over 1 hour with dexamethasone 8 mg. PO BID for five days. EP dosages were kept static; docetaxel dosages were explored in a minimum of three patients per level for dosages of 40, 60, 70, and 80 mg/m2. Patients were evaluated weekly. Prostate specific antigen (PSA) was measured every three weeks. RESULTS: Five patients were entered at a docetaxel dose of 40 mg/m2, three at 60 mg/m2, six at 70 mg/m2, and three at 80 mg/m2. Only one patient had received prior chemotherapy. Grades 1 or 2 hypocalcemia and hypophosphatemia were seen at all dosage levels. Other grade 2 or less toxicities not related to dosage included alopecia, anorexia, stomatitis, diarrhea, and epigastric pain. Dose limiting toxicities (DLT) as grade 4 leukopenia and grade 4 fatigue were seen at 80 mg/m2. The phase II dose was defined at 70 mg/m2 with rapidly reversible leukopenia and minor liver function abnormalities. At this dosing level, dose intensity was 88% and 86% over consecutive cycles for docetaxel and EP, respectively. Two vascular events occurred at this dose level (70 mg/m2): one arterial and the other venous. PSA decreases greater than 50% from baseline were seen in 14 of 17 patients at all dosage levels. Four of the 17 patients demonstrated a complete biochemical response (PSA < or = 4 ng/ml). One patient had a partial response with measurable lung and liver lesions. CONCLUSION: EP given continuously with every three-week docetaxel at a dose of 70 mg/m2 is tolerable with evidence of antitumor activity based upon significant declines in PSA in the majority of patients and improvement of lung metastasis in one patient. Larger phase II studies of this combination in a homogenous population are warranted.  (+info)

Treatment of localized primary non-Hodgkin's lymphoma of bone in children: a Pediatric Oncology Group study. (8/5419)

PURPOSE: The treatment of primary lymphoma of bone (PLB) in children has traditionally included radiotherapy to the primary site; more recently, it has included systemic chemotherapy. Because of concern about the untoward effects of treatment in a disease that is curable, we attempted to determine whether radiotherapy can be safely excluded from treatment. PATIENTS AND METHODS: The results of three consecutive Pediatric Oncology Group (POG) studies were examined to determine the impact on outcome of radiotherapy as adjunctive treatment in children and adolescents receiving chemotherapy for early-stage primary lymphoma of bone. RESULTS: From 1983 to 1997, 31 patients with localized PLB were entered onto POG studies of early-stage non-Hodgkin's lymphoma (NHL). Between 1983 and 1986, seven patients were treated with 8 months of chemotherapy with irradiation (XRT) of the primary site. After 1986, patients were treated without XRT; four received 8 months of chemotherapy, and 20 received 9 weeks of chemotherapy. Primary sites were the femur (nine), tibia (eight), mandible (five), mastoid (one), maxilla (one), zygomatic arch (one), rib (one), clavicle (one), scapula (one), ulna (one), talus (one), and calcaneous (one). Histologic classification revealed 21 cases of large cell lymphoma, five cases of lymphoblastic lymphoma, two cases of small, noncleaved-cell lymphoma, and three cases of NHL that could not be classified further. One patient relapsed at a distant site 22 months after completion of therapy. There have been no deaths. CONCLUSION: Localized PLB is curable in most children and adolescents with a 9-week chemotherapy regimen of modest intensity, and radiotherapy is an unnecessary adjunct.  (+info)

Bone neoplasms are abnormal growths or tumors that develop in the bone. They can be benign (non-cancerous) or malignant (cancerous). Benign bone neoplasms do not spread to other parts of the body and are rarely a threat to life, although they may cause problems if they grow large enough to press on surrounding tissues or cause fractures. Malignant bone neoplasms, on the other hand, can invade and destroy nearby tissue and may spread (metastasize) to other parts of the body.

There are many different types of bone neoplasms, including:

1. Osteochondroma - a benign tumor that develops from cartilage and bone
2. Enchondroma - a benign tumor that forms in the cartilage that lines the inside of the bones
3. Chondrosarcoma - a malignant tumor that develops from cartilage
4. Osteosarcoma - a malignant tumor that develops from bone cells
5. Ewing sarcoma - a malignant tumor that develops in the bones or soft tissues around the bones
6. Giant cell tumor of bone - a benign or occasionally malignant tumor that develops from bone tissue
7. Fibrosarcoma - a malignant tumor that develops from fibrous tissue in the bone

The symptoms of bone neoplasms vary depending on the type, size, and location of the tumor. They may include pain, swelling, stiffness, fractures, or limited mobility. Treatment options depend on the type and stage of the tumor but may include surgery, radiation therapy, chemotherapy, or a combination of these treatments.

"Bone" is the hard, dense connective tissue that makes up the skeleton of vertebrate animals. It provides support and protection for the body's internal organs, and serves as a attachment site for muscles, tendons, and ligaments. Bone is composed of cells called osteoblasts and osteoclasts, which are responsible for bone formation and resorption, respectively, and an extracellular matrix made up of collagen fibers and mineral crystals.

Bones can be classified into two main types: compact bone and spongy bone. Compact bone is dense and hard, and makes up the outer layer of all bones and the shafts of long bones. Spongy bone is less dense and contains large spaces, and makes up the ends of long bones and the interior of flat and irregular bones.

The human body has 206 bones in total. They can be further classified into five categories based on their shape: long bones, short bones, flat bones, irregular bones, and sesamoid bones.

Bone remodeling is the normal and continuous process by which bone tissue is removed from the skeleton (a process called resorption) and new bone tissue is formed (a process called formation). This ongoing cycle allows bones to repair microdamage, adjust their size and shape in response to mechanical stress, and maintain mineral homeostasis. The cells responsible for bone resorption are osteoclasts, while the cells responsible for bone formation are osteoblasts. These two cell types work together to maintain the structural integrity and health of bones throughout an individual's life.

During bone remodeling, the process can be divided into several stages:

1. Activation: The initiation of bone remodeling is triggered by various factors such as microdamage, hormonal changes, or mechanical stress. This leads to the recruitment and activation of osteoclast precursor cells.
2. Resorption: Osteoclasts attach to the bone surface and create a sealed compartment called a resorption lacuna. They then secrete acid and enzymes that dissolve and digest the mineralized matrix, creating pits or cavities on the bone surface. This process helps remove old or damaged bone tissue and releases calcium and phosphate ions into the bloodstream.
3. Reversal: After resorption is complete, the osteoclasts undergo apoptosis (programmed cell death), and mononuclear cells called reversal cells appear on the resorbed surface. These cells prepare the bone surface for the next stage by cleaning up debris and releasing signals that attract osteoblast precursors.
4. Formation: Osteoblasts, derived from mesenchymal stem cells, migrate to the resorbed surface and begin producing a new organic matrix called osteoid. As the osteoid mineralizes, it forms a hard, calcified structure that gradually replaces the resorbed bone tissue. The osteoblasts may become embedded within this newly formed bone as they differentiate into osteocytes, which are mature bone cells responsible for maintaining bone homeostasis and responding to mechanical stress.
5. Mineralization: Over time, the newly formed bone continues to mineralize, becoming stronger and more dense. This process helps maintain the structural integrity of the skeleton and ensures adequate calcium storage.

Throughout this continuous cycle of bone remodeling, hormones, growth factors, and mechanical stress play crucial roles in regulating the balance between resorption and formation. Disruptions to this delicate equilibrium can lead to various bone diseases, such as osteoporosis, where excessive resorption results in weakened bones and increased fracture risk.

Bone density refers to the amount of bone mineral content (usually measured in grams) in a given volume of bone (usually measured in cubic centimeters). It is often used as an indicator of bone strength and fracture risk. Bone density is typically measured using dual-energy X-ray absorptiometry (DXA) scans, which provide a T-score that compares the patient's bone density to that of a young adult reference population. A T-score of -1 or above is considered normal, while a T-score between -1 and -2.5 indicates osteopenia (low bone mass), and a T-score below -2.5 indicates osteoporosis (porous bones). Regular exercise, adequate calcium and vitamin D intake, and medication (if necessary) can help maintain or improve bone density and prevent fractures.

Bone resorption is the process by which bone tissue is broken down and absorbed into the body. It is a normal part of bone remodeling, in which old or damaged bone tissue is removed and new tissue is formed. However, excessive bone resorption can lead to conditions such as osteoporosis, in which bones become weak and fragile due to a loss of density. This process is carried out by cells called osteoclasts, which break down the bone tissue and release minerals such as calcium into the bloodstream.

Bone marrow is the spongy tissue found inside certain bones in the body, such as the hips, thighs, and vertebrae. It is responsible for producing blood-forming cells, including red blood cells, white blood cells, and platelets. There are two types of bone marrow: red marrow, which is involved in blood cell production, and yellow marrow, which contains fatty tissue.

Red bone marrow contains hematopoietic stem cells, which can differentiate into various types of blood cells. These stem cells continuously divide and mature to produce new blood cells that are released into the circulation. Red blood cells carry oxygen throughout the body, white blood cells help fight infections, and platelets play a crucial role in blood clotting.

Bone marrow also serves as a site for immune cell development and maturation. It contains various types of immune cells, such as lymphocytes, macrophages, and dendritic cells, which help protect the body against infections and diseases.

Abnormalities in bone marrow function can lead to several medical conditions, including anemia, leukopenia, thrombocytopenia, and various types of cancer, such as leukemia and multiple myeloma. Bone marrow aspiration and biopsy are common diagnostic procedures used to evaluate bone marrow health and function.

Bone marrow cells are the types of cells found within the bone marrow, which is the spongy tissue inside certain bones in the body. The main function of bone marrow is to produce blood cells. There are two types of bone marrow: red and yellow. Red bone marrow is where most blood cell production takes place, while yellow bone marrow serves as a fat storage site.

The three main types of bone marrow cells are:

1. Hematopoietic stem cells (HSCs): These are immature cells that can differentiate into any type of blood cell, including red blood cells, white blood cells, and platelets. They have the ability to self-renew, meaning they can divide and create more hematopoietic stem cells.
2. Red blood cell progenitors: These are immature cells that will develop into mature red blood cells, also known as erythrocytes. Red blood cells carry oxygen from the lungs to the body's tissues and carbon dioxide back to the lungs.
3. Myeloid and lymphoid white blood cell progenitors: These are immature cells that will develop into various types of white blood cells, which play a crucial role in the body's immune system by fighting infections and diseases. Myeloid progenitors give rise to granulocytes (neutrophils, eosinophils, and basophils), monocytes, and megakaryocytes (which eventually become platelets). Lymphoid progenitors differentiate into B cells, T cells, and natural killer (NK) cells.

Bone marrow cells are essential for maintaining a healthy blood cell count and immune system function. Abnormalities in bone marrow cells can lead to various medical conditions, such as anemia, leukopenia, leukocytosis, thrombocytopenia, or thrombocytosis, depending on the specific type of blood cell affected. Additionally, bone marrow cells are often used in transplantation procedures to treat patients with certain types of cancer, such as leukemia and lymphoma, or other hematologic disorders.

Bone development, also known as ossification, is the process by which bone tissue is formed and grows. This complex process involves several different types of cells, including osteoblasts, which produce new bone matrix, and osteoclasts, which break down and resorb existing bone tissue.

There are two main types of bone development: intramembranous and endochondral ossification. Intramembranous ossification occurs when bone tissue forms directly from connective tissue, while endochondral ossification involves the formation of a cartilage model that is later replaced by bone.

During fetal development, most bones develop through endochondral ossification, starting as a cartilage template that is gradually replaced by bone tissue. However, some bones, such as those in the skull and clavicles, develop through intramembranous ossification.

Bone development continues after birth, with new bone tissue being laid down and existing tissue being remodeled throughout life. This ongoing process helps to maintain the strength and integrity of the skeleton, allowing it to adapt to changing mechanical forces and repair any damage that may occur.

Bone diseases is a broad term that refers to various medical conditions that affect the bones. These conditions can be categorized into several groups, including:

1. Developmental and congenital bone diseases: These are conditions that affect bone growth and development before or at birth. Examples include osteogenesis imperfecta (brittle bone disease), achondroplasia (dwarfism), and cleidocranial dysostosis.
2. Metabolic bone diseases: These are conditions that affect the body's ability to maintain healthy bones. They are often caused by hormonal imbalances, vitamin deficiencies, or problems with mineral metabolism. Examples include osteoporosis, osteomalacia, and Paget's disease of bone.
3. Inflammatory bone diseases: These are conditions that cause inflammation in the bones. They can be caused by infections, autoimmune disorders, or other medical conditions. Examples include osteomyelitis, rheumatoid arthritis, and ankylosing spondylitis.
4. Degenerative bone diseases: These are conditions that cause the bones to break down over time. They can be caused by aging, injury, or disease. Examples include osteoarthritis, avascular necrosis, and diffuse idiopathic skeletal hyperostosis (DISH).
5. Tumors and cancers of the bone: These are conditions that involve abnormal growths in the bones. They can be benign or malignant. Examples include osteosarcoma, chondrosarcoma, and Ewing sarcoma.
6. Fractures and injuries: While not strictly a "disease," fractures and injuries are common conditions that affect the bones. They can result from trauma, overuse, or weakened bones. Examples include stress fractures, compound fractures, and dislocations.

Overall, bone diseases can cause a wide range of symptoms, including pain, stiffness, deformity, and decreased mobility. Treatment for these conditions varies depending on the specific diagnosis but may include medication, surgery, physical therapy, or lifestyle changes.

Bone regeneration is the biological process of new bone formation that occurs after an injury or removal of a portion of bone. This complex process involves several stages, including inflammation, migration and proliferation of cells, matrix deposition, and mineralization, leading to the restoration of the bone's structure and function.

The main cells involved in bone regeneration are osteoblasts, which produce new bone matrix, and osteoclasts, which resorb damaged or old bone tissue. The process is tightly regulated by various growth factors, hormones, and signaling molecules that promote the recruitment, differentiation, and activity of these cells.

Bone regeneration can occur naturally in response to injury or surgical intervention, such as fracture repair or dental implant placement. However, in some cases, bone regeneration may be impaired due to factors such as age, disease, or trauma, leading to delayed healing or non-union of the bone. In these situations, various strategies and techniques, including the use of bone grafts, scaffolds, and growth factors, can be employed to enhance and support the bone regeneration process.

Pancreatic neoplasms refer to abnormal growths in the pancreas that can be benign or malignant. The pancreas is a gland located behind the stomach that produces hormones and digestive enzymes. Pancreatic neoplasms can interfere with the normal functioning of the pancreas, leading to various health complications.

Benign pancreatic neoplasms are non-cancerous growths that do not spread to other parts of the body. They are usually removed through surgery to prevent any potential complications, such as blocking the bile duct or causing pain.

Malignant pancreatic neoplasms, also known as pancreatic cancer, are cancerous growths that can invade and destroy surrounding tissues and organs. They can also spread (metastasize) to other parts of the body, such as the liver, lungs, or bones. Pancreatic cancer is often aggressive and difficult to treat, with a poor prognosis.

There are several types of pancreatic neoplasms, including adenocarcinomas, neuroendocrine tumors, solid pseudopapillary neoplasms, and cystic neoplasms. The specific type of neoplasm is determined through various diagnostic tests, such as imaging studies, biopsies, and blood tests. Treatment options depend on the type, stage, and location of the neoplasm, as well as the patient's overall health and preferences.

Bone matrix refers to the non-cellular component of bone that provides structural support and functions as a reservoir for minerals, such as calcium and phosphate. It is made up of organic and inorganic components. The organic component consists mainly of type I collagen fibers, which provide flexibility and tensile strength to the bone. The inorganic component is primarily composed of hydroxyapatite crystals, which give bone its hardness and compressive strength. Bone matrix also contains other proteins, growth factors, and signaling molecules that regulate bone formation, remodeling, and repair.

Erysipelas is a skin infection characterized by the rapid onset of sharply demarcated, raised, and indurated (hardened) red plaques or patches with surrounding edema (swelling). It is typically caused by group A Streptococcus bacteria (\*Streptococcus pyogenes*). The infection involves the upper dermis and superficial lymphatics, resulting in painful, tender, warm, and erythematous (red) lesions. Erysipelas can also present with fever, chills, malaise, and generalized fatigue. Common sites for this infection include the face and lower extremities. Treatment usually involves antibiotics to eliminate the bacterial infection and supportive care to manage symptoms. If left untreated, erysipelas can lead to severe complications such as sepsis or necrotizing fasciitis.

"History, 19th Century" is not a medical term or concept. It refers to the historical events, developments, and figures related to the 1800s in various fields, including politics, culture, science, and technology. However, if you are looking for medical advancements during the 19th century, here's a brief overview:

The 19th century was a period of significant progress in medicine, with numerous discoveries and innovations that shaped modern medical practices. Some notable developments include:

1. Edward Jenner's smallpox vaccine (1796): Although not strictly within the 19th century, Jenner's discovery laid the foundation for vaccination as a preventive measure against infectious diseases.
2. Germ theory of disease: The work of Louis Pasteur, Robert Koch, and others established that many diseases were caused by microorganisms, leading to the development of antiseptic practices and vaccines.
3. Anesthesia: In 1842, Crawford Long first used ether as an anesthetic during surgery, followed by the introduction of chloroform in 1847 by James Simpson.
4. Antisepsis and asepsis: Joseph Lister introduced antiseptic practices in surgery, significantly reducing postoperative infections. Later, the concept of asepsis (sterilization) was developed to prevent contamination during surgical procedures.
5. Microbiology: The development of techniques for culturing and staining bacteria allowed for better understanding and identification of pathogens.
6. Physiology: Claude Bernard's work on the regulation of internal body functions, or homeostasis, contributed significantly to our understanding of human physiology.
7. Neurology: Jean-Martin Charcot made significant contributions to the study of neurological disorders, including multiple sclerosis and Parkinson's disease.
8. Psychiatry: Sigmund Freud developed psychoanalysis, a new approach to understanding mental illnesses.
9. Public health: The 19th century saw the establishment of public health organizations and initiatives aimed at improving sanitation, water quality, and vaccination programs.
10. Medical education reforms: The Flexner Report in 1910 led to significant improvements in medical education standards and practices.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Williams Syndrome is a rare genetic disorder caused by the deletion of a small portion of chromosome 7. This results in various developmental and medical problems, which can include:

1. Distinctive facial features such as a broad forehead, wide-set eyes, short nose, and full lips.
2. Cardiovascular disease, particularly narrowed or missing blood vessels near the heart.
3. Developmental delays and learning disabilities, although most people with Williams Syndrome have an IQ in the mild to moderate range of intellectual disability.
4. A unique pattern of strengths and weaknesses in cognitive skills, such as strong language skills but significant difficulty with visual-spatial tasks.
5. Overly friendly or sociable personality, often displaying a lack of fear or wariness around strangers.
6. Increased risk of anxiety and depression.
7. Sensitive hearing and poor depth perception.
8. Short stature in adulthood.

Williams Syndrome affects about 1 in every 10,000 people worldwide, regardless of race or ethnic background. It is not an inherited disorder, but rather a spontaneous genetic mutation.

A nomogram is a graphical representation of a mathematical formula or equation that allows the user to quickly solve a problem by simply drawing a line between different values on the chart. In the field of medicine, nomograms are often used as a tool for predicting patient outcomes, assessing risk, or making diagnostic decisions based on specific clinical data.

For example, a nomogram may be used to estimate the probability of survival in patients with a particular type of cancer, based on factors such as age, tumor size, and stage of disease. The user would locate the appropriate values for each factor on the nomogram, draw a line connecting them, and read off the estimated probability at the intersection point.

Nomograms can be a useful and intuitive way to communicate complex medical information and help clinicians make informed decisions in a timely manner. However, it is important to note that nomograms are only as accurate as the data they are based on, and should always be used in conjunction with clinical judgment and other relevant factors.

I believe you are looking for a medical definition or association with the name "Connecticut." However, I couldn't find any specific medical condition or term named after Connecticut. Connecticut is one of the 50 states in the United States and has no direct relation to medical terminology. If you have more context or information, please let me know so I can provide a more accurate response.

Streptococcus pyogenes is a Gram-positive, beta-hemolytic streptococcus bacterium that causes various suppurative (pus-forming) and nonsuppurative infections in humans. It is also known as group A Streptococcus (GAS) due to its ability to produce the M protein, which confers type-specific antigenicity and allows for serological classification into more than 200 distinct Lancefield groups.

S. pyogenes is responsible for a wide range of clinical manifestations, including pharyngitis (strep throat), impetigo, cellulitis, erysipelas, scarlet fever, rheumatic fever, and acute poststreptococcal glomerulonephritis. In rare cases, it can lead to invasive diseases such as necrotizing fasciitis (flesh-eating disease) and streptococcal toxic shock syndrome (STSS).

The bacterium is typically transmitted through respiratory droplets or direct contact with infected skin lesions. Effective prevention strategies include good hygiene practices, such as frequent handwashing and avoiding sharing personal items, as well as prompt recognition and treatment of infections to prevent spread.

Public health is defined by the World Health Organization (WHO) as "the art and science of preventing disease, prolonging life and promoting human health through organized efforts of society." It focuses on improving the health and well-being of entire communities, populations, and societies, rather than individual patients. This is achieved through various strategies, including education, prevention, surveillance of diseases, and promotion of healthy behaviors and environments. Public health also addresses broader determinants of health, such as access to healthcare, housing, food, and income, which have a significant impact on the overall health of populations.

Medical genetics is the branch of medicine that involves the study of inherited conditions and diseases, as well as the way they are passed down through families. It combines elements of clinical evaluation, laboratory testing, and genetic counseling to help diagnose, manage, and prevent genetic disorders. Medical genetics also includes the study of genetic variation and its role in contributing to both rare and common diseases. Additionally, it encompasses the use of genetic information for pharmacological decision making (pharmacogenomics) and reproductive decision making (preimplantation genetic diagnosis, prenatal testing).

Genomics is the scientific study of genes and their functions. It involves the sequencing and analysis of an organism's genome, which is its complete set of DNA, including all of its genes. Genomics also includes the study of how genes interact with each other and with the environment. This field of study can provide important insights into the genetic basis of diseases and can lead to the development of new diagnostic tools and treatments.

Health policy refers to a set of decisions, plans, and actions that are undertaken to achieve specific healthcare goals within a population. It is formulated by governmental and non-governmental organizations with the objective of providing guidance and direction for the management and delivery of healthcare services. Health policies address various aspects of healthcare, including access, financing, quality, and equity. They can be designed to promote health, prevent disease, and provide treatment and rehabilitation services to individuals who are sick or injured. Effective health policies require careful consideration of scientific evidence, ethical principles, and societal values to ensure that they meet the needs of the population while being fiscally responsible.

Research, in the context of medicine, is a systematic and rigorous process of collecting, analyzing, and interpreting information in order to increase our understanding, develop new knowledge, or evaluate current practices and interventions. It can involve various methodologies such as observational studies, experiments, surveys, or literature reviews. The goal of medical research is to advance health care by identifying new treatments, improving diagnostic techniques, and developing prevention strategies. Medical research is typically conducted by teams of researchers including clinicians, scientists, and other healthcare professionals. It is subject to ethical guidelines and regulations to ensure that it is conducted responsibly and with the best interests of patients in mind.

Public health practice is a multidisciplinary approach that aims to prevent disease, promote health, and protect communities from harmful environmental and social conditions through evidence-based strategies, programs, policies, and interventions. It involves the application of epidemiological, biostatistical, social, environmental, and behavioral sciences to improve the health of populations, reduce health disparities, and ensure equity in health outcomes. Public health practice includes a wide range of activities such as disease surveillance, outbreak investigation, health promotion, community engagement, program planning and evaluation, policy analysis and development, and research translation. It is a collaborative and systems-based approach that involves partnerships with various stakeholders, including communities, healthcare providers, policymakers, and other organizations to achieve population-level health goals.

Health services research (HSR) is a multidisciplinary field of scientific investigation that studies how social factors, financing systems, organizational structures and processes, health technologies, and personal behaviors affect access to healthcare, the quality and cost of care, and ultimately, our health and well-being. The goal of HSR is to inform policy and practice, improve system performance, and enhance the health and well-being of individuals and communities. It involves the use of various research methods, including epidemiology, biostatistics, economics, sociology, management science, political science, and psychology, to answer questions about the healthcare system and how it can be improved.

Examples of HSR topics include:

* Evaluating the effectiveness and cost-effectiveness of different healthcare interventions and technologies
* Studying patient-centered care and patient experiences with the healthcare system
* Examining healthcare workforce issues, such as shortages of primary care providers or the impact of nurse-to-patient ratios on patient outcomes
* Investigating the impact of health insurance design and financing systems on access to care and health disparities
* Analyzing the organization and delivery of healthcare services in different settings, such as hospitals, clinics, and long-term care facilities
* Identifying best practices for improving healthcare quality and safety, reducing medical errors, and eliminating wasteful or unnecessary care.

Coley, William (1949). Neoplasms of Bone. New York: Medical Book Department of Harper & Brothers. pp. 565-570. Chang AE, Shu S ... Dashiell visited Coley after suffering from a hand injury which he soon discovered to be an aggressive bone tumor. Treatment ... McCarthy, Edward (2006). "The Toxins of William B. Coley and the Treatment of Bone and Soft-Tissue Sarcomas". The Iowa ... William Bradley Coley (January 12, 1862 - April 16, 1936) was an American bone surgeon and cancer researcher best known for his ...
Oliveira AM, Chou MM (January 2014). "USP6-induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular ... Oliveira AM, Chou MM (January 2014). "USP6-induced neoplasms: the biologic spectrum of aneurysmal bone cyst and nodular ... They typically present with a tumor in areas of the head that lay directly over the temporal or parietal bones. Individual ... Hiemcke-Jiwa LS, van Gorp JM, Fisher C, Creytens D, van Diest PJ, Flucke U (December 2020). "USP6-Associated Neoplasms: A ...
Due to thin bone and weak barriers, the neoplasm can extend into the sinonasal passages, pterygomaxillary fossa and eventually ... Smaller mandibular neoplasms have been enucleated where the cavity of the tumour is curetted, allowing preservation of the bone ... Recurrence within a bone graft (following resection of the original tumor) does occur, but is less common. Seeding to the bone ... Preferable removal includes 10mm of normal bone around the neoplasm. Larger ameloblastomas can require partial resection of the ...
Myeloid neoplasms always concern bone marrow cell lineage and are related to hematopoietic cells. Myeloid tissue can also be ... Myeloid tissue, in the bone marrow sense of the word myeloid (myelo- + -oid), is tissue of bone marrow, of bone marrow cell ... Yuan J, Nguyen CK, Liu X, Kanellopoulou C, Muljo SA (2012). "Lin28b reprograms adult bone marrow hematopoietic progenitors to ... lineage, or resembling bone marrow, and myelogenous tissue (myelo- + -genous) is any tissue of, or arising from, bone marrow; ...
Effect of Sr90 Upon Life Span and Neoplasms of Bone and the Blood-forming Tissues. Miriam P. Finkel, Birute O. Biskis, and ... Delayed effects of bone-seeking radionuclides (Ed. Mays, C.W., et al.). 417. Finkel, M. P., Biskis, B. O., & Jinkins, P. B. ( ... Finkel, M. P., Biskis, B. O., & Scribner, G. M. (1958). The influence of strontium-90 upon life span and neoplasms of mice (No ... 1960). Illinois bone tumor death certificate study. Annual report-Division of Biological and Medical Research. Argonne National ...
... is an uncommon osteoid tissue-forming primary neoplasm of the bone. It has clinical and histologic manifestations ... of all primary bone tumors and only 14% of benign bone tumors making it a relatively rare form of bone tumor.[citation needed] ... Bone scintigraphy (bone scan) demonstrates abnormal radiotracer accumulation at the affected site, substantiating clinical ... Therefore, bone scans are useful only in conjunction with other radiologic studies and are not best used alone.[citation needed ...
Leukaemias are subdivided into lymphoid and myeloid neoplasms, depending on which bone marrow cells are cancerous. The myeloid ... In adults, blood cells are formed in the bone marrow, by a process that is known as haematopoiesis. In CMML, there are ... Bone marrow core biopsies may show a predominance of myelocytic and monocytic cells, abnormal localisation of immature ... The FAB criteria for diagnosis are as follows: Monocyte count >1x109/L 0-19% blasts in bone marrow 1x109/L No Philadelphia ...
While chondrosarcoma is the most common form of a secondary malignant bone neoplasm found in cases of Ollier disease, other ... Early detection and consistent and repeated monitoring is important in order to prevent and treat any potential bone neoplasms ... Clinical and radiological evaluations are conducted in order to detect the presence of bone neoplasms or lesions typically ... Abnormal bone growth such as shortening or thickening and deformity may be observed in patients of Ollier disease. These bone ...
Overall survival prognosis is about 30%. Deaths due to malignant neoplasms of the bones and joints account for an unknown ... usually associated with an underlying bone pathology such as Paget's disease of bone. Osteosarcoma is the most common bone ... Large doses of Sr-90, nicknamed bone seeker, increases the risk of bone cancer and leukemia in animals and is presumed to do so ... The tumor causes a great deal of pain, and can even lead to fracture of the affected bone. As with human osteosarcoma, bone ...
Other embolizations are also performed for symptom relief or prior to surgery to reduce bleeding Bone Cancer: bone metastases ... such as osteoporosis or underlying neoplasm. Analogous to vertebroplasty, the purpose of sacroplasty is to provide ... to stabilize the bone. These treatments may be palliatively for bone metastases pain or for some cases such as osteoid osteoma ... A needle is placed through the skin and into the bone under CT guidance and a polymethylmethacrylate mixture is injected into ...
In cases of a supposed myeloid neoplasm, a bone marrow biopsy will be performed utilizing cytogenetic analysis. This type of ... A bone marrow aspirate may be utilized to confirm an increase in basophils or significantly high numbers of precursors to the ... Elevation of basophils may also be representative of multiple other underlying neoplasms such as polycythemia vera (PV), ... The root cause of basophilia can be determined through a bone marrow biopsy, genetic testing to look for genetic mutations, or ...
It may also occur with fractures of the facial bones, neoplasms, during asthma attacks, as an adverse effect of the Heimlich ...
A phosphaturic mesenchymal tumor is an extremely rare benign neoplasm of soft tissue and bone that inappropriately produces ... Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL (July 2000). "MEPE, a new gene expressed in bone marrow and ... Adult patients may present with worsening musculoskeletal symptoms, muscle weakness, myalgias, bone pains and fatigue which are ... Journal of Bone and Mineral Research. 22 (6): 931-937. doi:10.1359/jbmr.070304. PMID 17352646. Chong WH, Molinolo AA, Chen CC, ...
... is a type of acute lymphoblastic leukemia with aggressive malignant neoplasm of the bone marrow. Acute lymphoblastic leukemia ( ... Bone marrow consists of a combination of solid and liquid components. Bone marrow aspiration and biopsies are typically done ... Patients often present extensive bone marrow involvement, mediastinal mass, adenopathy, CNS involvement, and splenomegaly. ... ALL) is a condition where immature white blood cells accumulate in the bone marrow, subsequently crowding out normal white ...
... system and intrathoracic organs 170 Malignant neoplasm of bone and articular cartilage 170.9 Malignant neoplasm of bone and ... 140 Malignant neoplasm of lip 141 Malignant neoplasm of tongue 142 Malignant neoplasm of major salivary glands 143 Malignant ... benign neoplasm of uterus 220 Benign neoplasm of ovary 221 Benign neoplasm of other female genital organs 222 Benign neoplasm ... neoplasm of oropharynx 147 Malignant neoplasm of nasopharynx 148 Malignant neoplasm of hypopharynx 149 Malignant neoplasm of ...
In oncology, polycythemia vera is an uncommon myeloproliferative neoplasm (chronic leukemia) in which the bone marrow makes too ... A bone marrow biopsy that shows hypercellularity and abnormalities in megakaryocytes; and The presence of a mutation in the ... "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): ... related risk factors for transformation to acute myeloid leukemia and myelodysplastic syndromes in myeloproliferative neoplasms ...
... gastrointestinal and malabsorption disorders muscle weakness bone pain Neonatal hypoglycemia Neoplasms Congenital diaphragmatic ... One of the most noted features of OGS is the increased risk of neoplasms in certain OGSs. SGBS in particular has been found to ... May include one or more of the following symptons: Macrosomia Macroglossia Advanced bone age Organomegaly is especially noted ... Limb patterning and skeletal development may also go awry when GPC3 mutations inhibit regulations of responses to bone ...
... tracheal neoplasms MeSH C04.588.448.200 - bone marrow neoplasms MeSH C04.588.531.500 - mammary neoplasms, experimental MeSH ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588. - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ... femoral neoplasms MeSH C04.588.149.721 - skull neoplasms MeSH C04.588.149.721.450 - jaw neoplasms MeSH C04.588.149.721.450.583 ...
Bone Cancer, Breast Neoplasms, Colorectal Neoplasms, Lung Neoplasms, Malignancies Multiple, Metastatic Cancer, Pancreatic ... Brain Neoplasm, Central Nervous System Neoplasm, High Grade Glioma: Gliosarcoma, Medulloblastomas, Oligodendroglioma, Acute T ... This delayed decrease in bone marrow activity generally occurs in the 4-6 week window after the drug's administration. Patients ... including but not limited to bone marrow immunosuppression, gastrointestinal issues, and hepatotoxicity. Lomustine is available ...
... pseudogout Neoplasms Neurovascular disorders Bone and cartilage disorders Extraarticular disorders Bursitis/Tendinitis of the ... Altorok, Nezam; Nada, Shigeyuki; Nagaraja, Vivek; Kahaleh, Bashar (2016-06-15). "Chapter 17 - Epigenetics in Bone and Joint ... Bone, Spine: Revue du Rhumatisme. Elsevier. 81 (2): 118-124. doi:10.1016/j.jbspin.2014.01.001. PMID 24556284. Murphy, Kenneth; ...
... bone marrow neoplasms MeSH C15.378.420.155 - anemia, sickle cell MeSH C15.378.420.155.440 - hemoglobin sc disease MeSH C15.378. ... bone marrow neoplasms MeSH C15.378.190.625 - myelodysplastic syndromes MeSH C15.378.190.625.062 - anemia, refractory MeSH ... splenic neoplasms MeSH C15.604.744.742 - splenic rupture MeSH C15.604.744.742.500 - splenosis MeSH C15.604.744.909 - ...
... and hematopoietic neoplasms of bone. Bone tumors may be classified as "primary tumors", which originate in bone or from bone- ... Stage 1A bone cancer Stage 1B bone cancer Stage 2A bone cancer Stage 2B bone cancer Stage 3 bone cancer Treatment of bone ... giant cell tumor of bone and aneurysmal bone cyst.[citation needed] Malignant primary bone tumors, known as bone sarcomas, ... Instead of amputation, the affected bone is removed and replaced in one of two ways: (a) bone graft, in which bone is taken ...
... will learn in depth about the pathology and treatment of various forms of primary benign and malignant neoplasms of the bones ... to the bones, which is much more common; these specialists deal mostly with primary bone tumors). The physician will study ... Due to the relative rarity of primary bone tumor in relation to other forms of cancer, there are fewer than two hundred ... it is advisable when confronted with primary malignancy of the bone to seek out the treatment of an orthopedic oncologist, due ...
A juvenile active ossifying fibroma is a benign fibro-osseous neoplasm composed of mixture of stroma and bone characterized by ... MRI shows a variable finding depending on T1 or T2 weighted images, dependent on the amount of bone to fibrous connective ... Many times the curved-shaped bone fragments have a collagenous rim around them. Ossicles may fuse to form much large ... When performing imaging studies, bone windows in computed tomography studies are the best. The lesion is usually identified as ...
... a malignant neoplasm of bone Open Scripting Architecture, for AppleScript Open Services Access, a set of standards for mobile ...
... a type of myeloproliferative neoplasm that affects the bone marrow; polycythemia vera, when there has been an inadequate ... Host Disease (GvHD) After Bone Marrow (REACH3)" at ClinicalTrials.gov Clinical trial number NCT03745638 for "TRuE AD1 - An ... Mesa RA (June 2010). "Ruxolitinib, a selective JAK1 and JAK2 inhibitor for the treatment of myeloproliferative neoplasms and ... Tefferi A (March 2012). "Challenges facing JAK inhibitor therapy for myeloproliferative neoplasms". The New England Journal of ...
The work of Aigner et al suggests that chondroblastoma should be reclassified as a bone-forming neoplasm versus a cartilaginous ... "Chondroblastoma of Bone." The Journal of Bone and Joint Surgery 82A.8 (2000): 1140-1145. Web. 6 Dec. 2015. Kurt, Ann-Marie, et ... However, local recurrence for long bone lesions is around 10%, with chondroblastoma in flat bones having higher recurrence and ... locally aggressive bone tumor that typically affects the epiphyses or apophyses of long bones. It is thought to arise from an ...
Infiltrative, highly cellular spindled cell neoplasm is poorly circumscribed and unencapsulated. Bone destruction or invasion ... Definitions: A low-grade spindle-cell neoplasm of the sinonasal tract associated with overlying respiratory epithelium and ...
Bone defects or fractures can occur in a number of ways, including trauma, neoplasm, osteoporosis, or congenital disorders. ... Coating an implant with RGD has been shown to improve bone cell adhesion, proliferation and survival. In vivo studies of such ... Modifying a titanium implant surface with a protein containing RGD improved bone mineralization and implant integration and ... There is therefore considerable interest in developing tissue engineered bone constructs, which should encourage tissue ...
... neoplasms can be separated into Hürthle cell adenomas and carcinomas, which are respectively benign and malignant ... On few occasions, patients with Hürthle cell carcinoma have distant metastases in the lungs or surrounding bones. Hürthle cell ... Some scientists have identified these mutations as deletions in the mitochondrial DNA of Hürthle cells found in neoplasms and ... References for findings: - Ayana Suzuki, C.T., Andrey Bychkov, M.D., Ph.D. "Hürthle cell neoplasm". Pathology Outlines.{{cite ...
Click to read Bone and Soft Tissue Neoplasms, by Bhavin Jankharia, a Substack publication with thousands of subscribers. ... Bone and Soft Tissue Neoplasms. Bone and soft tissue neoplasms - diagnosis and understanding ...
"Myelodysplastic/Myeloproliferative Neoplasms", Tumors of the Bone Marrow, Kathryn Foucar, MD, Steven H. Kroft, MD, Robert W. ...
2024 The George Washington University School of Medicine and Health Sciences Powered by the EthosCE Learning Management System, a continuing education LMS. ...
Coley, William (1949). Neoplasms of Bone. New York: Medical Book Department of Harper & Brothers. pp. 565-570. Chang AE, Shu S ... Dashiell visited Coley after suffering from a hand injury which he soon discovered to be an aggressive bone tumor. Treatment ... McCarthy, Edward (2006). "The Toxins of William B. Coley and the Treatment of Bone and Soft-Tissue Sarcomas". The Iowa ... William Bradley Coley (January 12, 1862 - April 16, 1936) was an American bone surgeon and cancer researcher best known for his ...
Malignant fibrous histiocytoma of bones: an important differential diagnosis of malignant bone neoplasms]. / Histiocitoma ... Malignant fibrous histiocytoma of bones: an important differential diagnosis of malignant [ ...
Bone Neoplasms* * Breast Neoplasms* * Female * Germ Cells / pathology * Human Papillomavirus Viruses * Humans ...
... and Fibroblast Subsets Drives Inflammation and Remodelling of the Bone Marrow Microenvironment in Myeloproliferative Neoplasms ... Cross-Talk between Hematopoietic Cells and Fibroblast Subsets Drives Inflammation and Remodelling of the Bone Marrow ...
Malignant neoplasm of vertebral column. C7951. Secondary malignant neoplasm of bone. C7952. Secondary malignant neoplasm of ... Secondary carcinoid tumors of bone. D166. Benign neoplasm of vertebral column. D480. Neoplasm of uncertain behavior of bone and ...
Enchondromas are benign cartilaginous neoplasms that are usually solitary lesions in intramedullary bone. The primary ... Benign chondroid neoplasms of bone. Semin Musculoskelet Radiol. 2000. 4(1):45-58. [QxMD MEDLINE Link]. ... with the bone void filled with autograft, allograft, bone substitute, or bone cement. [4, 5, 6] ... Radionuclide bone scan findings are nonspecific; therefore, one cannot reliably diagnose a focal bone lesion on the basis of ...
Malignant neoplasm of bone and articular cartilage, unspecified. C44. Other and unspecified malignant neoplasm of skin. ... Encounter for aftercare following bone marrow transplant. Z48.810. Encounter for surgical aftercare following surgery on the ...
Bone marrow disease called myeloproliferative neoplasm (which includes polycythemia vera). *Spleen removal (splenectomy) ...
... or other malignant neoplasms affecting the bone marrow or lymphatic system; 3) infants on immunosuppressive therapy (including ... Bone Marrow Transplant 1993;12:573--6.. * Yolken RH, Bishop CA, Townsend TR. Infectious gastroenteritis in bone-marrow ... Bone Marrow Transplant 2005;36:691--4.. * Rayani A, Bode U, Habas E, et al. Rotavirus infections in paediatric oncology ... Children and adults who are immunocompromised because of congenital immunodeficiency or because of bone marrow or solid organ ...
Bone Neoplasms 28% * Testicular Neoplasms 26% * Family history of head and neck cancers. Li, X., Koskinen, A. I., Hemminki, O. ...
Neoplasms, Bone Tissue [C04.557.450.565.575]. *Giant Cell Tumor of Bone [C04.557.450.565.575.420] ... The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed) ... A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. ... This graph shows the total number of publications written about "Giant Cell Tumor of Bone" by people in Harvard Catalyst ...
Ovarian Neoplasms 1 * Running 1 * General Surgery 1 * Bone Neoplasms 1 * Breast 1 ... Gynecology, Women's Health, Affect, Breast Neoplasms, Congress, Continuity of Patient Care, Health, Health Personnel, ...
2130.0 Other malignant neoplasms Includes: Metastatic carcinoma Brain tumor Bone cancer Carcinoma-in-situ, NOS. 2135.0 ... 2150.0 Neoplasm of uncertain nature Excludes: Neoplasm, NOS Brain tumor (2130.0). ENDOCRINE, NUTRITIONAL, AND METABOLIC ... NEOPLASMS (2100-2199). Malignant neoplasms:. 2100.0 Cancer, gastrointestinal tract Includes: Esophagus Stomach Small intestine ... Benign and uncertain nature neoplasms:. 2140.0 Fibroids and other uterine neoplasms Includes: Myoma Leiomyomata Cervical polyp ...
Leukemia, lymphoma, blood dyscrasias and other malignant neoplasms affecting the lymphatic systems or bone marrow. ... primary or acquired immunodeficiency states or other malignant neoplasms that affect the lymphatic system or bone marrow; ... aplastic anemia (anemia due to the bone marrows inability to produce platelets, red and white blood cells); ... other malignant conditions which affected the lymphatic systems or bone marrow, pregnant women, nursing mothers, and persons ...
... is the most common primary tumor of the bone, found most commonly in the extremities, with a bimodal age distribution.[1] ... Osteosarcoma is a mesenchymal neoplasm that produces osteoid as well as the woven bone matrix.[23] Production of the osteoid ... Review Osteosarcoma in Pagets disease of bone.[J Bone Miner Res. 2006]. Review Osteosarcoma in Pagets disease of bone.. ... Tc 99 whole-body bone scanning or F 18 - FDG PETmay be indicated for ruling out other sites of bone to bone metastasis, "skip ...
... progressive bone marrow failure syndrome characterized by the triad of reticulated skin hyperpigmentation, nail dystrophy, and ... Heterozygous RTEL1 variants in bone marrow failure and myeloid neoplasms. Blood Adv. 2018 Jan 9. 2 (1):36-48. [QxMD MEDLINE ... Bone mineral density in patients with inherited bone marrow failure syndromes. Pediatr Res. 2017 Sep. 82 (3):458-464. [QxMD ... Treatment of inherited bone marrow failure syndromes beyond transplantation. Hematology Am Soc Hematol Educ Program. 2017 Dec 8 ...
... refer to benign neoplasms of smooth muscle, bone, cartilage, glandular tissue, and blood vessel tissue, respectively. The ... Necrosis may be seen in inflammatory conditions, as well as in NEOPLASMS. NEOPLASM, or NEOPLASIA A "new growth" of the bodys ... bone marrow. In adults, the sample is usually taken from the pelvic bone, typically from the posterior superior iliac spine. ... to extract core of bone. The calcium is removed from the bone to make it soft, the tissue is processed (see "Specimen ...
The disorders known as bone marrow failure syndromes (BMFS) are life-threatening disorders characterized by absence of one or ... The disorders known as bone marrow failure syndromes (BMFS) are life-threatening disorders characterized by absence of one or ... This article is part of the Research Topic Advances in Predisposition to Bone Marrow Failure and Hematopoietic Neoplasms View ... Increased Ripk1-mediated bone marrow necroptosis leads to myelodysplasia and bone marrow failure in mice. Blood. (2019) 133(2): ...
Hypercalcemia is associated with renal failure, neoplasms, bone destruction, parathyroid hormone (PTH)-releasing tumors, and ...
Osteochondroma is the most common skeletal neoplasm of all benign bone tumors. However, it rarely occurs subungually. In this ... Radiographically, it appears as hypertrophy of soft tissues and bones. The pathologic findings are infiltration and hypertrophy ...
Identifying recurrent genetic alterations in myeloid neoplasms has improved diagnosis and expanded targeted treatments ... In myeloid neoplasms, the bone marrow produces too many or too few red blood cells, platelets, or certain white blood cells. ... Faster genomics-based diagnosis may accelerate targeted treatment of patients with myeloid neoplasms. ... Faster genomics-based diagnosis may accelerate targeted treatment of patients with myeloid neoplasms. by Elsevier ...
Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm. ... Article: BONE MARROW TRANSPLANTATION. 2021;56(4):807-817 Vitamin D levels and busulphan kinetics in patients undergoing ...
Kidney Neoplasms, Lung Neoplasms, Bone Diseases, Diagnostic Imaging, Drainage, Carotid Arteries, Medical Oncology, Neoplasms, ... Bone Neoplasms, Pulmonary Embolism, Vena Cava Filters, Myoma, Vertebroplasty, Prostatic Hyperplasia, Arteriovenous ... Neoplasm Metastasis, Hepatic Insufficiency, Colorectal Surgery, Carcinoma, Chemoembolization, Therapeutic, ...
... and the significant failure of CT and bone scan to identify bone metastases, this study questioned the adequacy of CT scan for ... bone (45 %), lymph node (32 %), and retroperitoneal (29 %). Although 14 patients had bone metastases, only 1 patient had a ... The locations of metastases were classified into the following categories: pulmonary, soft tissue, bone, retroperitoneal, ... Soft Tissue Neoplasms. *Oncology & Carcinogenesis. *Liposarcoma, Myxoid. *Humans. *Follow-Up Studies. *Bone Neoplasms ...
Plasma cell neoplasms form tumors in the bones or soft tissues of the body. ... and plasma cell neoplasms (14 percent lower risk compared to normal). ...
  • It is a rare, progressive bone marrow failure syndrome characterized by the triad of reticulated skin hyperpigmentation, nail dystrophy, and oral leukoplakia. (medscape.com)
  • Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. (medscape.com)
  • Homozygous autosomal recessive mutations in RTEL1 lead to similar phenotypes that parallel with Hoyeraal-Hreidarsson (HH) syndrome, a severe variant of DKC characterized by cerebellar hypoplasia, bone marrow failure, intrauterine growth restriction and immunodeficiency. (medscape.com)
  • In myeloid neoplasms, the bone marrow produces too many or too few red blood cells , platelets, or certain white blood cells. (medicalxpress.com)
  • Specimens included synthetic DNA (101 targets) and RNA (9 targets) controls and real-world nucleic acid material derived from bone marrow or peripheral blood samples (40 patients). (medicalxpress.com)
  • Clinical DNA and RNA samples were retrospectively identified from blood or bone marrow specimens that had already undergone nucleic acid extraction and genetic testing in a Clinical Laboratory Improvement Amendments (CLIA) certified clinical laboratory following previously validated protocols. (medicalxpress.com)
  • and neoplasm = new abnormal growth, such as a precancer or cancer), the blood-producing cells in the bone marrow (precursor cells, also called stem cells) develop and reproduce excessively or are crowded out by an overgrowth of fibrous tissue. (msdmanuals.com)
  • Platelets (sometimes called thrombocytes) are cell fragments produced in the bone marrow that circulate in the bloodstream and help blood to clot. (msdmanuals.com)
  • Thrombopoietin, primarily produced in the liver, stimulates the bone marrow to make large cells (megakaryocytes), which in turn make platelets from material inside their cell body (cytoplasm). (msdmanuals.com)
  • Primary Site/Histology--Heme & Lymphoid Neoplasms: What are the correct primary site and histology for patient diagnosed with an oropharyngeal soft tissue mass revealing plasma cell neoplasm with 5-10% of marrow cellularity in 2022? (cancer.gov)
  • One patient transitioned to bone marrow transplantation. (ascopost.com)
  • When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called T acute lymphoblastic leukemia. (mycancergenome.org)
  • Myeloproliferative neoplasm is a term used to describe a group of rare blood disorders that affect the bone marrow. (thesaurus.net)
  • These disorders produce too many blood cells in the bone marrow, which can lead to various complications. (thesaurus.net)
  • He explained that CMML is a neoplasm that overlaps myelodysplastic syndrome and myeoloproliferative neoplasms, with proliferative and dysplastic subtypes. (ascopost.com)
  • It is used to treat severe hypercalcemia and osteolytic bone lesions associated with malignant neoplasms and in the prevention and treatment of postmenopausal osteoporosis. (e-lactancia.org)
  • Results show the biologic effects of vinyl halide exposure to include changes in behavior, cardiovascular abnormalities, degenerative changes in the liver and bones, and the induction of malignant neoplasms, especially angiosarcomas of the liver. (cdc.gov)
  • The study enrolled 29 patients with symptomatic splenomegaly or myeloproliferative neoplasms with a Myeloproliferative Neoplasm-Symptom Assessment Form Total Symptom Score (MDS-SAF TSS) of at least 17. (ascopost.com)
  • Synonyms for the term include myeloproliferative disorder, myeloproliferative syndrome, chronic myeloproliferative neoplasm, and myeloproliferative disease. (thesaurus.net)
  • What are the hypernyms for Myeloproliferative neoplasm? (thesaurus.net)
  • Enchondromas constitute 3-10% of all bone tumors and 12-24% of benign bone tumors. (medscape.com)
  • Enchondromas are the most common tumors of the bones of the hand. (medscape.com)
  • In a study of 48 patients by Sollaci et al, tumors more frequently presented in the ulnar side of the hand, in the fifth ray and the proximal bones. (medscape.com)
  • Vascularized Medial Femoral Condyle Periosteal Flaps With Allograft Bone for Distal Radius Giant Cell Tumors: A Case Report. (harvard.edu)
  • 1% of all bone tumors 1 . (radiopaedia.org)
  • Osteomas are benign tumors of growing bone that present in a periosteal or endosteal form and commonly affect the craniofacial skeleton bones, being rarely found in other parts of the body. (bvsalud.org)
  • A spectrum of malignant tumors arising from the bone, characterized morphologically by the presence of small round cells. (medindex.am)
  • Enchondromas are benign cartilaginous neoplasms that are usually solitary lesions in intramedullary bone occurring most commonly in small bones of the hands and feet. (medscape.com)
  • The lesions replace normal bone with mineralized or unmineralized hyaline cartilage, thereby generating a lytic pattern on radiographs or, more commonly, a lytic area containing rings and arcs of chondroid calcifications. (medscape.com)
  • CMF accounts for one of the 'C's in the popular mnemonic for lucent bone lesions FEGNOMASHIC . (radiopaedia.org)
  • However, this is non-specific and can be seen in many other bone lesions. (radiopaedia.org)
  • Fine-needle aspiration biopsy in the diagnosis and management of bone lesions: a study of 450 cases. (nih.gov)
  • It is an uncommon, benign, but locally aggressive neoplasm. (washington.edu)
  • The myeloproliferative neoplasms (MPN) are a class of incurable diseases that may have great effects on patients. (lls.org)
  • When present, they are often found in the mandible, maxilla, frontal bone and paranasal sinuses. (bvsalud.org)
  • Malignant fibrous histiocytoma of bones: an important differential diagnosis of malignant bone neoplasms]. (bvsalud.org)
  • Identifying recurrent genetic alterations in myeloid neoplasms has improved diagnosis and expanded targeted treatments available to patients. (medicalxpress.com)
  • Although 14 patients had bone metastases, only 1 patient had a sclerotic/blastic presentation visualized on CT scan, and the diagnosis for the remaining 13 patients was determined by magnetic resonance imaging (MRI). (duke.edu)
  • The age of the patient, the location and apparent perforation of the bone is all in support of odontogenic keratocyst (OKC) and for that reason, should be considered and placed high on the differential diagnosis list. (washington.edu)
  • They are slow-growing neoplasms, usually asymptomatic, which can develop in compact or cancellous bone. (bvsalud.org)
  • Despite this aggressive growth, they often remain asymptomatic, thus growing to large sizes and hollowing the bone. (washington.edu)
  • Management of enchondromas typically consists of simple curettage with bone grafting, with the bone void filled with autograft, allograft, bone substitute, or bone cement. (medscape.com)
  • Because of pain, the lesion was curetted and packed with morselized allograft bone. (medscape.com)
  • Some investigators advocate marsupialization and occasionally resection of the more aggressive cysts that tend to perforate buccal and lingual bone. (washington.edu)
  • Diffuse Pulmonary Metastases at Presentation of Giant Cell Tumor of Bone: A Case Report and Synthesis of Literature. (harvard.edu)
  • CONCLUSION: Due to metastatic disease identified outside surveillance imaging for 58 % of the patients, the diversity of locations, and the significant failure of CT and bone scan to identify bone metastases, this study questioned the adequacy of CT scan for surveillance of MLS. (duke.edu)
  • In this sense, physical exercise has been an ally in the treatment of patients with bone metastases. (bvsalud.org)
  • Systematic review and meta-analysis on the safety and benefits of physical exercise in patients with bone metastases. (bvsalud.org)
  • No adverse musculoskeletal effects were observed during the intervention, with exercise being significantly safe in individuals with bone metastases. (bvsalud.org)
  • Therapy with aerobic and isometric exercises is safe in patients with bone metastases, in addition, it improves pain, but without significant increase of aerobic capacity, disease progression, body mass and quality of life. (bvsalud.org)
  • Malignant giant cell tumour of bone: a review of clinical, pathological and imaging features. (harvard.edu)
  • Perform a thorough clinical and laboratory examination, keeping in mind the patient's increased risk of neoplasms. (medscape.com)
  • larger OKCs tend to expand bone, but mildly-obvious clinical expansion (which is the case in this patient) should be viewed with suspicion for a neoplasm. (washington.edu)
  • The latter is most often the case in bones with little overlying soft tissues (e.g. short tubular bones of the hands and feet). (radiopaedia.org)
  • The classical site is the upper one-third of the tibia, which accounts for 25% of all cases, with the small tubular bones of the foot, the distal femur, and pelvis/sacrum being other relatively common locations 12 . (radiopaedia.org)
  • Dashiell visited Coley after suffering from a hand injury which he soon discovered to be an aggressive bone tumor. (wikipedia.org)
  • Giant Cell Tumor of Bone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. (harvard.edu)
  • The tumor occurs most frequently in an end of a long tubular bone in young adults. (harvard.edu)
  • This graph shows the total number of publications written about "Giant Cell Tumor of Bone" by people in Harvard Catalyst Profiles by year, and whether "Giant Cell Tumor of Bone" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Giant Cell Tumor of Bone" by people in Profiles. (harvard.edu)
  • Sclerostin immunohistochemical staining in surgically treated giant cell tumor of bone. (harvard.edu)
  • Immunohistochemical Characterization of Giant Cell Tumor of Bone Treated With Denosumab: Support for Osteoblastic Differentiation. (harvard.edu)
  • Giant Cell Tumor of Bone With Cartilage Matrix: A Clinicopathologic Study of 17 Cases. (harvard.edu)
  • On bone scans , the scintigraphic " doughnut sign " has been described in this tumor type 11 . (radiopaedia.org)
  • malignant tumor of bones which always arises in medullary tissue, occurring more often in cylindrical bones, with pain, fever, and leukocytosis. (medindex.am)
  • The discovery of recurrent genetic alterations in myeloid neoplasms has improved diagnostic accuracy and expanded the targeted treatment options available to patients. (medicalxpress.com)
  • Myeloproliferative neoplasms are caused by genetic mutations. (msdmanuals.com)
  • William Bradley Coley (January 12, 1862 - April 16, 1936) was an American bone surgeon and cancer researcher best known for his early contributions to the study of cancer immunotherapy, specifically causing infection as a way to fight cancer, a practice used as far back as 1550 BC. (wikipedia.org)
  • November 28, 2020 - When cancer spreads to the bones, it can cause pain, reduce mobility and increase the risk of fractures. (ohri.ca)
  • However the described expansion of the bone is unlike the behavior of an OKC that hollows rather than expands bone, neither is the lack of tooth vitality. (washington.edu)
  • The age of the patient, the expansion and perforation of bone are all in support of the behavior of a neoplasm including a neoplasm of tooth origin such as an odontogenic myxoma. (washington.edu)
  • Primary analyses allowed for a 6-month lag period (ie, exposure begins 6 months after initiation) to account for a hypothesised delay in the onset of any clinically meaningful effect of SSRIs on bone mineral density. (bmj.com)
  • Aneurysmal bone cyst and osteoblastoma after neoadjuvant denosumab: histologic spectrum and potential diagnostic pitfalls. (harvard.edu)
  • Mrinal S. Patnaik, MBBS , Chair of the Acute Leukemia and Myeloid Neoplasms Group and Scientific Director of the Epigenetics Developmental Laboratory and the Epigenomics Program at the Mayo Clinic, Rochester, Minnesota, offered his thoughts on the phase II study findings of ruxolitinib's efficacy in CMML. (ascopost.com)
  • A neoplasm of lymphoblasts committed to the T-cell lineage, typically composed of small to medium-sized blast cells. (mycancergenome.org)
  • The lesion involves the diaphysis and approaches the end of the bone near the metacarpophalangeal joint. (medscape.com)
  • Odontogenic keratocyst is an aggressive cyst known for its rapid growth and its tendency to invade the adjacent tissues, including bone. (washington.edu)
  • This finding is not uncommon in enchondromas of the small bones. (medscape.com)
  • abstract = "Aims: To determine whether patients receiving hemi-body irradiation required further treatment to painful bone sites out with the radiation field (skull or lower leg), whether patients required further treatment to areas within the treated radiation field for pain or new skeletal events, and whether the treatment outcome was successful in terms of pain control. (dundee.ac.uk)
  • While there is currently no cure for myeloproliferative neoplasms, treatment options are available that aim to manage symptoms and improve quality of life. (thesaurus.net)
  • The fellowship focuses on achieving a comprehensive understanding of the basic principles of MSK imaging including MRI and CT imaging protocol optimization for sports medicine, bone and soft tissue neoplasms, rheumatologic disease and arthrography. (umassmed.edu)
  • As such if an en-bloc resection is possible this is advisable 14 . (radiopaedia.org)
  • Frontal radiograph of the right hand demonstrates a lytic expansile lesion in the fifth metacarpal bone, with thinning of the cortex that has a somewhat scalloped appearance. (medscape.com)
  • There is a high rate of reported recurrence (up to 80%) with curettage alone, with a lower rate (~20%) with bone grafting. (radiopaedia.org)
  • It usually presents before the onset of puberty and is often located within the long bones. (medscape.com)
  • Most chondromyxoid fibromas are located in the metaphyseal region of long bones (60%) and may extend to the epiphyseal line and even rarely abut the articular surface 3,12 . (radiopaedia.org)
  • flat bones, especially the pelvis, can also be affected. (medscape.com)
  • A wide range of diagnostic services including radiography, US, CT, MRI, and arthrography are complemented by an active MSK interventional service providing diagnostic arthrography, joint injections, and bone and soft tissue biopsies. (umassmed.edu)

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