Bone Morphogenetic Proteins
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
Bone Morphogenetic Protein 2
Bone Morphogenetic Protein 4
Bone Morphogenetic Protein 7
Bone Morphogenetic Protein Receptors, Type I
Bone Morphogenetic Protein Receptors
Bone Morphogenetic Protein 6
Bone Morphogenetic Protein Receptors, Type II
Bone and Bones
Bone Morphogenetic Protein 5
A bone morphogenetic protein that may play a role in CARTILAGE formation. It is a potent regulator of the growth of CHONDROCYTES and the synthesis of cartilage matrix proteins. Evidence for its role in cartilage formation can be seen in MICE, where genetic mutations that cause loss of bone morphogenetic protein 5 function result in the formation of small malformed ears.
Smad1 Protein
Smad Proteins
A family of proteins that are involved in the translocation of signals from TGF-BETA RECEPTORS; BONE MORPHOGENETIC PROTEIN RECEPTORS; and other surface receptors to the CELL NUCLEUS. They were originally identified as a class of proteins that are related to the mothers against decapentaplegic protein, Drosophila and sma proteins from CAENORHABDITIS ELEGANS.
Bone Morphogenetic Protein 3
Smad5 Protein
Bone Morphogenetic Protein 15
Bone Morphogenetic Protein 1
A bone morphogenetic protein family member that includes an active tolloid-like metalloproteinase domain. The metalloproteinase activity of bone morphogenetic protein 1 is specific for the removal of the C-propeptide of PROCOLLAGEN and may act as a regulator of EXTRACELLULAR MATRIX deposition. Alternative splicing of MRNA for bone morphogenetic protein 1 results in the production of several PROTEIN ISOFORMS.
Transforming Growth Factor beta
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Bone Remodeling
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Smad6 Protein
Smad8 Protein
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Growth Differentiation Factor 2
A growth differentiation factor that plays a regulatory role as a paracrine factor for a diverse array of cell types during EMBRYONIC DEVELOPMENT and in the adult tissues. Growth differentiation factor 2 is also a potent regulator of CHONDROGENESIS and was previously referred to as bone morphogenetic protein 9.
Cell Differentiation
Osteoblasts
Bone Regeneration
Bone Density
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Receptors, Growth Factor
Growth Differentiation Factors
Growth Differentiation Factor 5
Bone Development
Gene Expression Regulation, Developmental
Growth Differentiation Factor 9
Bone Matrix
Activin Receptors, Type I
Growth Differentiation Factor 6
Activins
Intercellular Signaling Peptides and Proteins
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Smad4 Protein
Activin Receptors, Type II
Cells, Cultured
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Bone Marrow Cells
Follistatin
A broadly distributed protein that binds directly to ACTIVINS. It functions as an activin antagonist, inhibits FOLLICLE STIMULATING HORMONE secretion, regulates CELL DIFFERENTIATION, and plays an important role in embryogenesis. Follistatin is a single glycosylated polypeptide chain of approximately 37-kDa and is not a member of the inhibin family (INHIBINS). Follistatin also binds and neutralizes many members of the TRANSFORMING GROWTH FACTOR BETA family.
Body Patterning
The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.
Mesoderm
Activin Receptors
Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.
Inhibitor of Differentiation Protein 1
Carrier Proteins
Smad Proteins, Receptor-Regulated
In Situ Hybridization
Alkaline Phosphatase
Tolloid-Like Metalloproteinases
Trans-Activators
MSX1 Transcription Factor
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Xenopus Proteins
Core Binding Factor Alpha 1 Subunit
Chondrogenesis
Stem Cells
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Calcification, Physiologic
Hypertension, Pulmonary
Reverse Transcriptase Polymerase Chain Reaction
Smad7 Protein
Hedgehog Proteins
Bone Substitutes
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Wnt Proteins
Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.
Hepcidins
Forms of hepcidin, a cationic amphipathic peptide synthesized in the liver as a prepropeptide which is first processed into prohepcidin and then into the biologically active hepcidin forms, including in human the 20-, 22-, and 25-amino acid residue peptide forms. Hepcidin acts as a homeostatic regulators of iron metabolism and also possesses antimicrobial activity.
Homeodomain Proteins
Osteocalcin
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Chick Embryo
Morphogenesis
Cartilage
Cell Lineage
Transcription Factors
Embryo, Nonmammalian
Gene Expression Regulation
DNA-Binding Proteins
Wnt3A Protein
Zebrafish Proteins
Mesenchymal Stromal Cells
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Receptors, Transforming Growth Factor beta
Cell-surface proteins that bind transforming growth factor beta and trigger changes influencing the behavior of cells. Two types of transforming growth factor receptors have been recognized. They differ in affinity for different members of the transforming growth factor beta family and in cellular mechanisms of action.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Embryo, Mammalian
Wnt3 Protein
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Zebrafish
Immunohistochemistry
Mice, Transgenic
Phenotype
Bone Marrow Transplantation
Gene Expression
Smad2 Protein
Mutation
Protein-Serine-Threonine Kinases
Fibroblast Growth Factors
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
Fracture Healing
Models, Biological
Periosteum
Neural Crest
The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.
Nodal Protein
The founding member of the nodal signaling ligand family of proteins. Nodal protein was originally discovered in the region of the mouse embryo primitive streak referred to as HENSEN'S NODE. It is expressed asymmetrically on the left side in chordates and plays a critical role in the genesis of left-right asymmetry during vertebrate development.
Pulmonary Artery
Protein Binding
Growth Substances
Embryonic Stem Cells
Blotting, Western
Gastrula
The developmental stage that follows BLASTULA or BLASTOCYST. It is characterized by the morphogenetic cell movements including invagination, ingression, and involution. Gastrulation begins with the formation of the PRIMITIVE STREAK, and ends with the formation of three GERM LAYERS, the body plan of the mature organism.
Embryonic Induction
Xenopus
Glycoproteins
Base Sequence
Amino Acid Sequence
Limb Deformities, Congenital
Inhibins
Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectively
Granulosa Cells
Supporting cells for the developing female gamete in the OVARY. They are derived from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the OOCYTE in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the OVUM in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors (RECEPTORS, LH).
Antimicrobial Cationic Peptides
Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.
Receptors, Cell Surface
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
Organogenesis
Osteoclasts
Phosphorylation
Extracellular Matrix Proteins
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
Inhibin-beta Subunits
Transforming Growth Factor beta1
A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
Up-Regulation
Genes, Reporter
Tibia
Bone Demineralization Technique
Paracrine Communication
DNA Primers
Inhibitor of Differentiation Proteins
Drosophila Proteins
Transcription, Genetic
Tissue Engineering
Hair Follicle
A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.
Growth Differentiation Factor 10
beta Catenin
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Down-Regulation
Disease Models, Animal
Osteocytes
Transfection
COS Cells
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
Cell Division
Cartilage, Articular
SOX9 Transcription Factor
Ovary
The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.
Collagen Type I
Odontogenesis
Myocytes, Smooth Muscle
Follistatin-Related Proteins
Promoter Regions, Genetic
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Osteoporosis
Stromal Cells
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Fibroblast Growth Factor 8
Culture Media, Conditioned
Synostosis
Transforming Growth Factor beta3
A TGF-beta subtype that plays role in regulating epithelial-mesenchymal interaction during embryonic development. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta3 and TGF-beta3 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
RNA Interference
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Gene Expression Profiling
Osseointegration
Transforming Growth Factor beta2
A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
Nervous System
Ovarian Follicle
An OOCYTE-containing structure in the cortex of the OVARY. The oocyte is enclosed by a layer of GRANULOSA CELLS providing a nourishing microenvironment (FOLLICULAR FLUID). The number and size of follicles vary depending on the age and reproductive state of the female. The growing follicles are divided into five stages: primary, secondary, tertiary, Graafian, and atretic. Follicular growth and steroidogenesis depend on the presence of GONADOTROPINS.
Membrane Proteins
Temporal Bone
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
Cumulus Cells
Smad3 Protein
Neurulation
Tissue Scaffolds
Growth differentiation factor-9 stimulates proliferation but suppresses the follicle-stimulating hormone-induced differentiation of cultured granulosa cells from small antral and preovulatory rat follicles. (1/115)
In addition to pituitary gonadotropins and paracrine factors, ovarian follicle development is also modulated by oocyte factors capable of stimulating granulosa cell proliferation but suppressing their differentiation. The nature of these oocyte factors is unclear. Because growth differentiation factor-9 (GDF-9) enhanced preantral follicle growth and was detected in the oocytes of early antral and preovulatory follicles, we hypothesized that this oocyte hormone could regulate the proliferation and differentiation of granulosa cells from these advanced follicles. Treatment with recombinant GDF-9, but not FSH, stimulated thymidine incorporation into cultured granulosa cells from both early antral and preovulatory follicles, accompanied by increases in granulosa cell number. Although GDF-9 treatment alone stimulated basal steroidogenesis in granulosa cells, cotreatment with GDF-9 suppressed FSH-stimulated progesterone and estradiol production. In addition, GDF-9 cotreatment attentuated FSH-induced LH receptor formation. The inhibitory effects of GDF-9 on FSH-induced granulosa cell differentiation were accompanied by decreases in the FSH-induced cAMP production. These data suggested that GDF-9 is a proliferation factor for granulosa cells from early antral and preovulatory follicles but suppresses FSH-induced differentiation of the same cells. Thus, oocyte-derived GDF-9 could account, at least partially, for the oocyte factor(s) previously reported to control cumulus and granulosa cell differentiation. (+info)Expression of growth and differentiation factor-9 in the ovaries of fetal sheep homozygous or heterozygous for the inverdale prolificacy gene (FecX(I)). (2/115)
Abnormal follicular and oocyte growth in ovaries of sheep homozygous (II) for the Inverdale gene, FecX(I), suggest that this gene may influence a fundamental event in initiation of folliculogenesis, with two copies of the gene inhibiting growth at the primordial/primary stage. In addition, striking similarities in ovarian morphology between mice deficient in growth and differentiation factor-9 (GDF-9) and II sheep suggest a relationship between the FecX(I) gene and GDF-9 function in the ovary. Therefore, it was hypothesized that GDF-9 mRNA expression would be inhibited in ovaries of II fetal sheep. To test this hypothesis, in situ hybridization was used to characterize GDF-9 mRNA expression in ovaries of homozygous (II), heterozygous (I+), and control (++) fetal sheep at Day 135 of gestation. GDF-9 mRNA expression was localized exclusively to oocytes from the type 1 follicle stage onward in all genotypes and is the first demonstration of GDF-9 mRNA expression in ovaries of fetal sheep. In addition, GDF-9 mRNA expression was detected in oocytes of abnormal type 2 follicles in the ovaries of II sheep. Thus, it does not appear that inhibition of GDF-9 gene expression is the mechanism of action whereby the FecX(I) gene exerts its influence. However, the possibility of translation at specific stages of follicular development cannot presently be ruled out. In addition, the FecX(I) gene may be involved, either directly or indirectly, in regulating expression of receptors for GDF-9. At present, however, neither the FecX(I) gene product nor the GDF-9 receptor has been isolated or characterized. (+info)Growth differentiation factor-9 stimulates progesterone synthesis in granulosa cells via a prostaglandin E2/EP2 receptor pathway. (3/115)
Growth differentiation factor-9 (GDF-9), an oocyte-secreted member of the transforming growth factor beta superfamily, progesterone receptor, cyclooxygenase 2 (Cox2; Ptgs2), and the EP2 prostaglandin E(2) (PGE(2)) receptor (EP2; Ptgerep2) are required for fertility in female but not male mice. To define the interrelationship of these factors, we used a preovulatory granulosa cell culture system in which we added recombinant GDF-9, prostaglandins, prostaglandin receptor agonists, or cyclooxygenase inhibitors. GDF-9 stimulated Cox2 mRNA within 2 h, and PGE(2) within 6 h; however, progesterone was not increased until 12 h after addition of GDF-9. This suggested that Cox2 is a direct downstream target of GDF-9 but that progesterone synthesis required an intermediate. To determine whether prostaglandin synthesis was required for progesterone production, we analyzed the effects of PGE(2) and cyclooxygenase inhibitors on this process. PGE(2) can stimulate progesterone synthesis by itself, although less effectively than GDF-9 (3-fold vs. 6-fold increase over 24 h, respectively). Furthermore, indomethacin or NS-398, inhibitors of Cox2, block basal and GDF-9-stimulated progesterone synthesis. However, addition of PGE(2) to cultures containing both GDF-9 and NS-398 overrides the NS-398 block in progesterone synthesis. To further define the PGE(2)-dependent pathway, we show that butaprost, a specific EP2 agonist, stimulates progesterone synthesis and overrides the NS-398 block. In addition, GDF-9 stimulates EP2 mRNA synthesis by a prostaglandin- and progesterone-independent pathway. Thus, GDF-9 induces an EP2 signal transduction pathway which appears to be required for progesterone synthesis in cumulus granulosa cells. These studies further demonstrate the importance of oocyte-somatic cell interactions in female reproduction. (+info)Growth differentiation factor-9 stimulates rat theca-interstitial cell androgen biosynthesis. (4/115)
Growth differentiation factor-9 (GDF-9) was shown recently to be essential for early follicular development, including the appearance of the theca layer. Theca cells provide the androgen substrate for aromatization and estrogen production by granulosa cells. Using biologically active recombinant GDF-9 (rGDF-9) and an androgen-producing immortalized theca-interstitial cell (TIC) line or primary TIC, we have examined the action of this paracrine hormone on theca cell steroidogenesis. The effect of GDF-9 on TIC progesterone synthesis was marginal and inconsistent in the primary cultures. In immortalized theca cells, GDF-9 attenuated the forskolin-stimulated progesterone accumulation. More significantly, this oocyte-derived growth factor enhanced both basal and stimulated androstenedione accumulation in the primary and transformed TIC cultures. The effects of GDF-9 on steroidogenesis by preovulatory follicles were relatively modest. Likewise, it did not affect the maturation of follicle-enclosed oocytes. The effect of GDF-9, an oocyte product, on TIC androgen production suggests a regulatory role of the oocyte on theca cell function and hence on follicle development and differentiation. This direct effect of GDF-9 on thecal steroidogenesis is consistent with its recently demonstrated actions on thecal cell recruitment and differentiation. (+info)Bone morphogenetic protein-15. Identification of target cells and biological functions. (5/115)
In developing ovarian follicles, the regulation of cell proliferation and differentiation is tightly coordinated. Precisely how this coordination is achieved is unknown, but recent observations have suggested that molecules emitted by the oocyte are involved in the process. The newly discovered oocyte-specific growth factor, bone morphogenetic protein-15 (BMP-15), is one such molecule. At present, nothing is known about the target cells and biological functions of BMP-15. To fill this gap in our knowledge, recombinant BMP-15 and its antibody were produced and used to determine BMP-15 expression and bioactivity. BMP-15 mRNA and protein were shown to be co-expressed in oocytes throughout folliculogenesis, supporting the idea that BMP-15 is a physiological regulator of follicle cell proliferation and/or differentiation. To test this, we used primary cultures of rat granulosa cells (GCs). We found that BMP-15 is a potent stimulator of GC proliferation, and importantly, the mitogenic effect was follicle-stimulating hormone (FSH)-independent. By contrast, BMP-15 alone had no effect on steroidogenesis. However, it produced a marked decrease in FSH-induced progesterone production, but had no effect on FSH-stimulated estradiol production. This result indicates that BMP-15 is a selective modulator of FSH action. In summary, this study identifies GCs as the first target cells for BMP-15. Moreover, it identifies the stimulation of GC proliferation and the differential regulation of two crucial steroid hormones as the first biological functions of BMP-15. Significantly, BMP-15 is the first growth factor that can coordinate GC proliferation and differentiation in a way that reflects normal physiology. (+info)Comparison of recombinant growth differentiation factor-9 and oocyte regulation of KIT ligand messenger ribonucleic acid expression in mouse ovarian follicles. (6/115)
Oocytes secrete factors that regulate the development of the surrounding granulosa cells in ovarian follicles. KIT ligand (KL) mRNA expression in granulosa cells is thought to be regulated by oocytes; however, the factor(s) that mediate this effect are not known. One candidate is the oocyte-specific gene product growth differentiation factor-9 (GDF-9). This study examined the effect of recombinant GDF-9 (rGDF-9) on steady-state KL mRNA expression levels in preantral and mural granulosa cells in vitro. Furthermore, the study compared the effect of rGDF-9 with that of coculture with oocytes at different developmental stages. As determined by RNase protection assay, both KL-1 and KL-2 mRNA levels in preantral and mural granulosa cells were suppressed by 25-250 ng/ml rGDF-9. Fully grown oocytes also suppressed both KL-1 and KL-2 mRNA expression levels. Partly grown oocytes isolated from 7-, 10-, or 12-day-old mice either had no effect on KL mRNA levels or promoted KL-1 mRNA steady-state expression. It is concluded that GDF-9 is likely to mediate the action of fully grown, but not partly grown, oocytes on granulosa cell KL mRNA expression. (+info)Bone morphogenetic protein-15 inhibits follicle-stimulating hormone (FSH) action by suppressing FSH receptor expression. (7/115)
We have recently reported that oocyte-derived bone morphogenetic protein-15 (BMP-15) can directly modulate follicle-stimulating hormone (FSH) action in rat granulosa cells. Here, we investigate underlying mechanisms of this BMP-15 effect. Treatment with BMP-15 alone exerted no significant effect on the basal expression of mRNAs encoding steroidogenic acute regulatory protein, P450 side chain cleavage enzyme, P450 aromatase, 3beta-hydroxysteroid dehydrogenase, luteinization hormone receptor, and inhibin/activin subunits. However, BMP-15 markedly inhibited the FSH-induced increases in these messages. In striking contrast, BMP-15 did not change the forskolin-induced levels of these transcripts. Thus, the inhibitory effect of BMP-15 on FSH action must be upstream of cAMP signaling. We next examined changes in FSH receptor mRNA expression. Interestingly, BMP-15 severely reduced the levels of FSH receptor mRNA in both basal and FSH-stimulated cells. To determine whether this effect was at the level of FSH function, we investigated the effect of BMP-15 on FSH bioactivity. Consistent with the mRNA data, BMP-15 inhibited the biological response of FSH, but not that of forskolin. Based on these results, we propose that BMP-15 is an important determinant of FSH action through its ability to inhibit FSH receptor expression. Because FSH plays an essential role in follicle growth and development, our findings could have new implications for understanding how oocyte growth factors contribute to folliculogenesis. (+info)Biological function and cellular mechanism of bone morphogenetic protein-6 in the ovary. (8/115)
The process of ovarian folliculogenesis is composed of proliferation and differentiation of the constitutive cells in developing follicles. Growth factors emitted by oocytes integrate and promote this process. Growth differentiation factor-9 (GDF-9), bone morphogenetic protein (BMP)-15, and BMP-6 are oocyte-derived members of the transforming growth factor-beta superfamily. In contrast to the recent studies on GDF-9 and BMP-15, nothing is known about the biological function of BMP-6 in the ovary. Here we show that, unlike BMP-15 and GDF-9, BMP-6 lacks mitogenic activity on rat granulosa cells (GCs) and produces a marked decrease in follicle-stimulating hormone (FSH)-induced progesterone (P(4)) but not estradiol (E(2)) production, demonstrating not only the first identification of GCs as BMP-6 targets in the ovary but also its selective modulation of FSH action in steroidogenesis. This BMP-6 activity resembles BMP-15 but differs from GDF-9 activities. BMP-6 also exhibited similar action to BMP-15 by attenuating the steady state mRNA levels of FSH-induced steroidogenic acute regulatory protein (StAR) and P450 side-chain cleavage enzyme (P450scc), without affecting P450 aromatase mRNA level, supporting its differential function on FSH-regulated P(4) and E(2) production. However, unlike BMP-15, BMP-6 inhibited forskolin- but not 8-bromo-cAMP-induced P(4) production and StAR and P450scc mRNA expression. BMP-6 also decreased FSH- and forskolin-stimulated cAMP production, suggesting that the underlying mechanism by which BMP-6 inhibits FSH action most likely involves the down-regulation of adenylate cyclase activity. This is clearly distinct from the mechanism of BMP-15 action, which causes the suppression of basal FSH receptor (FSH-R) expression, without affecting adenylate cyclase activity. As assumed, BMP-6 did not alter basal FSH-R mRNA levels, whereas it inhibited FSH- and forskolin- but not 8-bromo-cAMP-induced FSH-R mRNA accumulation. These studies provide the first insight into the biological function of BMP-6 in the ovary and demonstrate its unique mechanism of regulating FSH action. (+info)
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Growth differentiation factor-9
2000). "Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/ ... Vitt U, Mazerbourg S, Klein C, Hsueh A (2002). "Bone morphogenetic protein receptor type II is a receptor for growth ... Vitt UA, Mazerbourg S, Klein C, Hsueh AJ (2003). "Bone morphogenetic protein receptor type II is a receptor for growth ... The cell surface receptor through which GDF9 generates a signal is the bone morphogenetic protein type II receptor (BMPR2). ...
Jennifer Juengel
1 April 2001). "Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein ... 1 December 2002). "Growth differentiation factor 9 and bone morphogenetic protein 15 are essential for ovarian follicular ... Jennifer L. Juengel; McNatty KP (10 February 2005). "The role of proteins of the transforming growth factor-beta superfamily in ...
Biochemical cascade
... bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions". Proceedings of the National Academy of ... ROS also interacts with ERK pathway that leads to activation of Ras, MEK and MEK-like proteins. These proteins activate protein ... Bone morphogenetic proteins/ Mothers against decapentaplegic/ Inhibitor of differentiation), mediated by transcription factors ... In TGF-β (Transforming Growth Factor β) pathway, BMP (Bone Morphogenic Protein), Activin and Nodal ligands bind to their ...
Elizabeth Robertson
Dudley, A. T.; Robertson, E. J. (1997). "Overlapping expression domains of bone morphogenetic protein family members ... "A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye". Genes & Development. 9 (22 ... Brennan, Jane; Norris, Dominic P.; Robertson, Elizabeth J. (15 September 2002). "Nodal activity in the node governs left-right ... Dudley, A. T.; Lyons, K. M.; Robertson, E. J. (15 November 1995). " ...
Mothers against decapentaplegic homolog 6
It acts as a regulator of TGFβ family (such as bone morphogenetic proteins) activity by competing with SMAD4 and preventing the ... Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (2001). "Promoting bone morphogenetic protein signaling through ... The SMAD proteins are homologs of both the drosophila protein, mothers against decapentaplegic (MAD) and the C. elegans protein ... SMAD family member 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene. SMAD6 is a protein that, ...
Mothers against decapentaplegic homolog 7
By occupying type I receptors for Activin and bone morphogenetic protein (BMP), it also plays a role in negative feedback of ... Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (August 2001). "Promoting bone morphogenetic protein signaling ... "Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B ... Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. SMAD7 is a protein ...
BMPR2
Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase. It binds Bone morphogenetic ... Bone morphogenetic protein, Developmental genes and proteins, TS domain, S/T kinase, Receptors, EC 2.7.11). ... BMPR2 is expressed on both human and animal granulosa cells, and is a crucial receptor for bone morphogenetic protein 15 (BMP15 ... Gilboa L, Nohe A, Geissendörfer T, Sebald W, Henis YI, Knaus P (March 2000). "Bone morphogenetic protein receptor complexes on ...
TGF beta signaling pathway
The BMPs bind to the bone morphogenetic protein receptor type-2 (BMPR2). They are involved in a multitude of cellular functions ... Bone morphogenetic proteins cause the transcription of mRNAs involved in osteogenesis, neurogenesis, and ventral mesoderm ... The TGF beta superfamily of ligands includes: Bone morphogenetic proteins (BMPs), Growth and differentiation factors (GDFs), ... "Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads". The EMBO Journal. 20 (15): ...
STAMBP
Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (August 2001). "Promoting bone morphogenetic protein signaling ... STAM-binding protein is a protein that in humans is encoded by the STAMBP gene. Cytokine-mediated signal transduction in the ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...
SMAD (protein)
Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (August 2001). "Promoting bone morphogenetic protein signaling ... "Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming ... potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein ... Thus, the two proteins could be caught in a "vicious cycle" of regulation. Pin1 causes both itself and Smad2 to be associated ...
Paracrine signaling
The BMPs bind to the bone morphogenetic protein receptor type II (BMPR2). Some of the proteins of the BMP family are BMP4 and ... Then active Smoothened protein is able to inhibit PKA and Slimb, so that the Ci protein is not cleaved. This intact Ci protein ... The binding of Wnt to a Frizzled protein activates the Dishevelled protein. In its active state the Dishevelled protein ... "Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads". The EMBO Journal. 20 (15): ...
SNIP1
"A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)". BMC ... Smad nuclear-interacting protein 1 is a protein that in humans is encoded by the SNIP1 gene. SNIP1 has been shown to interact ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-1178. Bibcode: ... Roche KC, Wiechens N, Owen-Hughes T, Perkins ND (2004). "The FHA domain protein SNIP1 is a regulator of the cell cycle and ...
PSMB4
"A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)". BMC ... The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key ... "A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)". BMC ... "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". ...
Bone morphogenetic protein 15
Developmental genes and proteins, Bone morphogenetic protein, TGFβ domain). ... Bone morphogenetic protein 15 (BMP-15) is a protein that in humans is encoded by the BMP15 gene. It is involved in ... Bragdon B, Moseychuk O, Saldanha S, King D, Julian J, Nohe A (April 2011). "Bone morphogenetic proteins: a critical review". ... Persani L, Rossetti R, Di Pasquale E, Cacciatore C, Fabre S (2014-11-01). "The fundamental role of bone morphogenetic protein ...
Bone morphogenetic protein 7
... or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the ... The protein encoded by this gene is a member of the TGF-β superfamily. Like other members of the bone morphogenetic protein ... Reddi AH (July 2000). "Bone morphogenetic proteins and skeletal development: the kidney-bone connection". Pediatric Nephrology ... bone morphogenetic protein 7 (BMP-7) versus autologous bone grafting for tibial fractures]". Der Unfallchirurg (in German). 110 ...
Bone morphogenetic protein 1
... , also known as BMP1, is a protein which in humans is encoded by the BMP1 gene. There are seven ... Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely ... 1993). "Mapping of the bone morphogenetic protein 1 gene (BMP1) to 8p21: removal of BMP1 from candidacy for the bone disorder ... BMP1 belongs to the peptidase M12A family of bone morphogenetic proteins (BMPs). It induces bone and cartilage development. ...
Bone morphogenetic protein 4
"Entrez Gene: BMP4 bone morphogenetic protein 4". Miyazono K, Kamiya Y, Morikawa M (January 2010). "Bone morphogenetic protein ... type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein ... Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. BMP4 is found on chromosome 14q22-q23. BMP4 ... It, like other bone morphogenetic proteins, is involved in bone and cartilage development, specifically tooth and limb ...
Alicia Bertone
... bone morphogenetic protein‐6 (BMP‐6) vector. She found BMP‐6 to be osteo-inductive in vivo resulting in acceleration of bone ... Her research indicated that transduction of BMDMSC with bone morphogenetic proteins‐2 or ‐6 can accelerate osteogenic ... "Mesenchymal Stem Cell-mediated Gene Delivery of Bone Morphogenetic Protein-2 in an Articular Fracture Model". Molecular Therapy ... "Gene-mediated osteogenic differentiation of stem cells by bone morphogenetic proteins-2 or -6". Journal of Orthopaedic Research ...
LDN193189
... is a chemical compound used in the study of bone morphogenetic protein signalling through the ALK2, ALK3 and ALK6 ... Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett. 2008 Aug ... Bone. 2018 Apr;109:251-258. doi:10.1016/j.bone.2017.09.004 PMID 28918311 (Articles without InChI source, Chemical pages without ... Bone morphogenetic protein, Quinolines, Phenylpiperazines, Pyrazolopyrimidines). ...
GDF6
1998). "Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis". J. Bone Miner ... GDF6 interacts with bone morphogenetic proteins (BMPs) to form heterodimers that may work to regulate neural induction and ... Reddi AH (1995). "Cartilage morphogenesis: role of bone and cartilage morphogenetic proteins, homeobox genes and extracellular ... 2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ...
A. Hari Reddi
... a bone morphogenetic protein. Matrix 1992; 12:369-80. Ripamonti U, Heliotis M, van den Heever B, Reddi AH. Bone morphogenetic ... isolation and purification of bone morphogenetic proteins (BMPs) that are involved in bone formation and repair. The molecular ... Osteogenin (bone morphogenetic protein-3) stimulates cartilage formation by chick limb bud cells in vitro. Dev Biol 1991; 146: ... Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth ...
Decapentaplegic
Dpp is the Drosophila homolog of the vertebrate bone morphogenetic proteins (BMPs), which are members of the TGF-β superfamily ... It is known to be necessary for the correct patterning and development of the early Drosophila embryo and the fifteen imaginal ... In Drosophila, the receptor for Dpp is formed by two proteins, Thickveins (Tkv) and Punt. Like Dpp itself, Tkv and Punt are ... When a cell receives a Dpp signal, the receptors are able to activate an intracellular protein called mothers against Dpp (mad ...
Bone
... and bone morphogenetic proteins. Evidence suggests that bone cells produce growth factors for extracellular storage in the bone ... Most of the bones of the skull are flat bones, as is the sternum. Sesamoid bones are bones embedded in tendons. Since they act ... Bone tissue is mineralized tissue of two types, cortical bone and cancellous bone. Other types of tissue found in bones include ... cancellous bone at the ends of the bones. Most bones of the limbs, including those of the fingers and toes, are long bones. The ...
Nicolaas Duneas
... bone morphogenetic protein-7) to initiate rapid bone formation". J Bone Miner Res. 12 (10): 1584-95. doi:10.1359/jbmr.1997.12. ... bone morphogenetic protein-7) to initiate rapid bone formation. (October 1997) Transforming growth factor-beta 1: induction of ... induction of bone morphogenetic protein genes expression during endochondral bone formation in the baboon, and synergistic ... "Enhanced activity of demineralised bone matrix augmented with xenogeneic bone morphogenetic protein complex in rats". South ...
Mothers against decapentaplegic homolog 2
... of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced ... The SMAD proteins are homologs of both the drosophila protein, mothers against decapentaplegic (MAD) and the C. elegans protein ... protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces ... Developmental genes and proteins, MH1 domain, MH2 domain, R-SMAD, Transcription factors, Human proteins). ...
Noggin (protein)
"Entrez Gene: NOG noggin". Blázquez-Medela AM, Jumabay M, Boström KI (May 2019). "Beyond the bone: Bone morphogenetic protein ... superfamily signaling proteins, such as bone morphogenetic protein 4 (BMP4). By diffusing through extracellular matrices more ... BMPedia - the Bone Morphogenetic Protein Wiki[permanent dead link] Noggin publications, gene expression data, sequences and ... Hall AK, Burke RM, Anand M, Dinsio KJ (July 2002). "Activin and bone morphogenetic proteins are present in perinatal sensory ...
Hepcidin
Core AB, Canali S, Babitt JL (2014). "Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis". ... hereditary hemochromatosis protein, transferrin receptor 2, bone morphogenic protein 6 (BMP6), matriptase-2, neogenin, BMP ... Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the ... NMR studies showed a new model for hepcidin: at ambient temperatures, the protein interconverts between two conformations, ...
ZNF423
Shim S, Bae N, Han JK (July 2002). "Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/ ... Zinc finger protein 423 is a protein that in humans is encoded by the ZNF423 gene. The protein encoded by this gene is a ... "ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression". The Journal ... OAZ+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ...
Osteogenesis imperfecta
Type XIII - OI caused by a mutation in the bone morphogenetic protein 1 (BMP1) gene on chromosome 8p21.3. This mutation causes ... Type XV - OI caused by homozygous or compound heterozygous mutations in the WNT1 gene on chromosome 12q13.12. It is autosomal ... Defects in these proteins lead to defective bone mineralization which causes the characteristic brittle bones of osteogenesis ... Defects in the proteins pigment epithelium-derived factor (PEDF) and bone-restricted interferon-induced transmembrane protein ( ...
Tomislav Smoljanović
In 2006, while examining the available literature on bone morphogenetic protein 2 (BMP-2), used to stimulate bone growth in ... for his research and campaigning which were instrumental in uncovering the harmful side effects of bone morphogenetic protein 2 ... Tomislav Smoljanović (born 15 July 1977) is a Croatian medical scientist, physician, and a retired rower. Smoljanović won ...
Spinal fusion
Bone morphogenetic protein (rhBMP) should not be routinely used in any type of anterior cervical spine fusion, such as with ... Life-threatening Complications Associated with Recombinant Human Bone Morphogenetic Protein in Cervical Spine Fusion". fda.gov ... "Recombinant human bone morphogenetic protein-2: adverse events reported to the Manufacturer and User Facility Device Experience ... bone graft or artificial bone substitute is packed between the vertebrae to help them heal together.[1] In general, fusions are ...
BMP binding endothelial regulator
... a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell ... "Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins". Biochemical and Biophysical Research Communications ... "BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis". Circulation Research ... BMP binding endothelial regulator is a protein that in humans is encoded by the BMPER gene. KLF15 is a strong and direct ...
Darwin's finches
Developmental research in 2004 found that bone morphogenetic protein 4 (BMP4), and its differential expression during ... 15, no. 1, pp. 1-53, CiteSeerX 10.1.1.458.3975, doi:10.1007/BF00132004, S2CID 17161535, retrieved 2008-12-09 Wikimedia Commons ...
Chordin
... dorsalizes the developing embryo by binding ventralizing TGFβ proteins such as bone morphogenetic proteins (BMP) ... "Not.S - Xnot protein - Xenopus laevis (African clawed frog) - not.S gene & protein". Larraín J, Bachiller D, Lu B, Agius E, ... There are five named isoforms of this protein that are produced by alternative splicing. CHRD is 23 exons long and has a length ... Chordin (from Greek χορδή, string, catgut) is a protein with a prominent role in dorsal-ventral patterning during early ...
LSP1
2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel ... Lymphocyte-specific protein 1 is a protein that in humans is encoded by the LSP1 gene. This gene encodes an intracellular F- ... Huang CK, Zhan L, Ai Y, Jongstra J (1997). "LSP1 is the major substrate for mitogen-activated protein kinase-activated protein ... Harrison RE, Sikorski BA, Jongstra J (2005). "Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and ...
Simpson-Golabi-Behmel syndrome
... and skeletal development may also go awry when GPC3 mutations inhibit regulations of responses to bone morphogenetic proteins, ... The function of this gene is to produce a protein that acts as a cell surface receptor that binds to transcription factors. ... Macrosomia Macroglossia Advanced bone age Organomegaly Neonatal hypoglycemia Neoplasms Congenital diaphragmatic hernia ( ... 25 (1): 8-15. doi:10.1038/sj.ijo.0801520. PMID 11244452. Simpson-Golabi-Behmel syndrome at NIH's Office of Rare Diseases ...
Interbody fusion cage
An Animal Model With and Without Bone Morphogenetic Protein". Spine. Lippincott-Raven. 23 (7): 758-765. doi:10.1097/00007632- ... and the Cortical Bone Dowel, which is cut from allograft femur. The cages can be packed with autologous bone material in order ... The Journal of Bone and Joint Surgery. American Volume. The Journal of Bone and Joint Surgery, Inc. 81 (6): 859-880. doi: ... J. W. Brantigan; A. D. Steffee (1993-10-15). "A carbon fiber implant to aid interbody lumbar fusion. Two-year clinical results ...
Development of the endocrine system
... gradient of pituitary morphogenesis is dependent on neuroectodermal signals from the infundibular bone morphogenetic protein 4 ... Other essential proteins necessary for pituitary cell proliferation are Fibroblast growth factor 8 (FGF8), Wnt4, and Wnt5. ... An assortment of genes and proteins - such as WNT4, RSPO1, FOXL2, and various estrogen receptors - have been shown to prevent ... May 1, 2002). "Parathyroid hormone is essential for normal fetal bone formation". J Clin Invest. 109 (9): 1173-1182. doi: ...
Eduardo Arzt
January 2006). "Bone morphogenetic protein-4 inhibits corticotroph tumor cells: involvement in the retinoic acid inhibitory ... February 2003). "Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/ ... October 2007). "RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia". ... Gerez, J; Tedesco, L; Bonfiglio, J J; Fuertes, M; Barontini, M; Silberstein, S; Wu, Y; Renner, U; Páez-Pereda, M (2014-12-15 ...
PIAS4
"The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway". Biochem. Biophys. Res ... E3 SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. It is also known as protein ... "Entrez Gene: PIAS4 Protein inhibitor of activated STAT, 4". Imoto, Seiyu; Sugiyama Kenji; Muromoto Ryuta; Sato Noriko; Yamamoto ... 2002). "Protein inhibitors of activated STAT resemble scaffold attachment factors and function as interacting nuclear receptor ...
Phenolic content in wine
... induces human osteoblast differentiation through bone morphogenetic protein-2/extracellular signal-regulated kinase 1/2 pathway ... This is due to the tendency of tannins to react with proteins, such as the ones found in saliva. In food and wine pairing, ... proteins and lipids from oxidative damage pursuant to Article 13(1) of Regulation (EC) No 1924/20061". EFSA Journal. 8 (2): ... foods that are high in proteins (such as red meat) are often paired with tannic wines to minimize the astringency of tannins. ...
Limb development
This model only specifies a "bare bones" pattern. Other factors like sonic hedgehog (Shh) and Hox proteins, primary ... Limb formation begins in the morphogenetic limb field, as mesenchymal cells from the lateral plate mesoderm proliferate to the ... In the development of most vertebrate limbs (though not in some amphibians), the cartilage skeleton is replaced by bone later ... Zhu J, Zhang YT, Alber MS, Newman SA (2010). "Bare bones pattern formation: a core regulatory network in varying geometries ...
Stem cell marker
"Differentiation of human pluripotent teratocarcinoma stem cells induced by bone morphogenetic protein-2". Reproduction, ... Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that ... Perry SS, Wang H, Pierce LJ, Yang AM, Tsai S, Spangrude GJ (April 2004). "L-selectin defines a bone marrow analog to the thymic ... Stahl J, Wobus AM, Ihrig S, Lutsch G, Bielka H (September 1992). "The small heat shock protein hsp25 is accumulated in P19 ...
Bat flight
Up-regulation of the bone morphogenetic protein (BMP) signaling pathway is also crucial in developmental and evolutionary ... Swartz, S. M., Bennett, M. B., & Carrier, D. R. (1992). Wing bone stresses in free flying bats and the evolution of skeletal ... The expansion of the long bones in bat wings is at at least partly attributed to paired-box (Pax) homeodomain transcription ... Bats also had to evolve a thinner cortical bone to reduce torsional stresses produced by propulsive downstroke movements. Bats ...
Tendon
Bone morphogenetic proteins (BMPs) are a subgroup of TGF-β superfamily that can induce bone and cartilage formation as well as ... Ligaments connect one bone to another, while tendons connect muscle to bone. Histologically, tendons consist of dense regular ... In this process, osteocytes infiltrate the tendon and lay down bone as they would in sesamoid bone such as the patella. In ... G-proteins, which induce intracellular signaling cascades, may also be important, and ion channels are activated by stretching ...
Morphogenesis
Bone morphogenetic protein Collective cell migration Embryonic development Pattern formation Turing pattern French flag model ... During assembly of the bacteriophage (phage) T4 virion, the morphogenetic proteins encoded by the phage genes interact with ... Phage T4 encoded proteins that determine virion structure include major structural components, minor structural components and ... Maintaining an appropriate balance in the amounts of each of these proteins produced during viral infection appears to be ...
Nuclear receptor coactivator 3
"Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation". J. Cell Sci. 112 (20): 3519 ... Liu F, Ventura F, Doody J, Massagué J (1995). "Human type II receptor for bone morphogenic proteins (BMPs): extension of the ... The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is ... The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment. ...
PMPCA
2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel ... This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins ... from mitochondrial protein precursors and releases of N-terminal transit peptides from precursor proteins imported into the ... which necessitates proper translocations of mitochondrial targeting proteins. Many mitochondrial proteins are synthesized in a ...
Evolution of the brain
Bone morphogenetic protein (BMP), a growth factor that plays a significant role in embryonic neural development, is highly ... "SPATA18 protein expression summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2022-06-02. Benton, Mary Lauren ... ZEB2 is a protein- coding gene in the Homo sapien species. A 2021 study found that a delayed change in the shape of early brain ... This, however, leads to a dilemma as the emergence of organisms with more complex nervous systems with protective bone or other ...
Perlecan
... the Bone Morphogenetic Protein 1/Tolloid-like family, releases the c-terminal endorepellin domain of the perlecan core protein ... Cartilage and bone development have proven to be dependent upon perlecan expression. The protein becomes visible by ... that the driving force behind heparanase and chondroitinase activation of osteogenesis is release of bone morphogenetic protein ... The HSPG2 gene codes for a 4,391 amino acid protein with a molecular weight of 468,829. It is one of the largest known proteins ...
Edward M. De Robertis
Together with his colleagues, he discovered Chordin, a protein secreted by dorsal cells that binds Bone Morphogenetic Protein ( ... De Robertis, Edward M.; Moriyama, Yuki (2016-01-01), Wassarman, Paul M. (ed.), "Chapter Thirteen - The Chordin Morphogenetic ... and protein degradation. He has also served for over two decades on the scientific board of the Pew Charitable Trusts Latin ... secreted frizzled-related proteins as inhibitors of tolloid proteinases". Cell. 124 (1): 147-159. doi:10.1016/j.cell.2005.12. ...
BMPR1A
"Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation". J. Bone Miner. Res. 10 (11): ... The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A ... "Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling". J. Biol. ... "Cartilage-derived morphogenetic proteins and osteogenic protein-1 differentially regulate osteogenesis". J. Bone Miner. Res. 13 ...
Three-finger protein
... and bone morphogenetic protein receptor, type IA. Other LU domain proteins are small globular proteins such as CD59 antigen, ... Three-finger proteins or three-finger protein domains (3FP or TFPD) are a protein superfamily consisting of small, roughly 60- ... Protein articles without symbol, Protein folds, Protein families). ... Members of the family have no enzymatic activity, but are capable of forming protein-protein interactions with high specificity ...
Endocrine system
... gradient of pituitary morphogenesis is dependent on neuroectodermal signals from the infundibular bone morphogenetic protein 4 ... Other essential proteins necessary for pituitary cell proliferation are Fibroblast growth factor 8 (FGF8), Wnt4, and Wnt5. ... Amino acid-based hormones (amines and peptide or protein hormones) are water-soluble and act on the surface of target cells via ... An assortment of genes and proteins - such as WNT4, RSPO1, FOXL2, and various estrogen receptors - have been shown to prevent ...
Bone morphogenetic protein 15 - Wikipedia
Developmental genes and proteins, Bone morphogenetic protein, TGFβ domain). ... Bone morphogenetic protein 15 (BMP-15) is a protein that in humans is encoded by the BMP15 gene. It is involved in ... Bragdon B, Moseychuk O, Saldanha S, King D, Julian J, Nohe A (April 2011). "Bone morphogenetic proteins: a critical review". ... Persani L, Rossetti R, Di Pasquale E, Cacciatore C, Fabre S (2014-11-01). "The fundamental role of bone morphogenetic protein ...
Primary Ovarian Insufficiency
Human Bone Morphogenetic Protein 15,BMP15 ELISA Kit - Brogen Medikal Teknolojileri
Human BMP15(Bone Morphogenetic Protein 15) ELISA Kit - LipidX
Human BMP15(Bone Morphogenetic Protein 15) ELISA Kit Human BMP15(Bone Morphogenetic Protein 15) ELISA Kit. To Order Contact us ... This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Bone Morphogenetic Protein 15 (BMP15 ... This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Bone Morphogenetic Protein 15 (BMP15 ... This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Bone Morphogenetic Protein 15 (BMP15 ...
Mika Laitinen - Publikationer - Helsingfors universitet
Bone morphogenetic protein 15 and growth differentiation factor 9 co-operate to regulate granulosa cell function. McNatty, K. P ... Bone morphogenetic protein 15 and growth differentiation factor 9 co-operate to regulate granulosa cell function in ruminants. ... Growth differentiation factor 9 and bone morphogenetic protein 15 are essential for ovarian follicular development in sheep. ... The bioactivity of human bone morphogenetic protein-15 is sensitive to C-terminal modification: Characterization of the ...
BMP2 (bone morphogenetic protein 2)
Bone morphogenetic protein-2 stimulates Runx2 acetylation.. 119. 21247344. 2011. High doses of bone morphogenetic protein 2 ... Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor ... Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in ... expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways.. 94. ...
Jorge H Calvo - Google Acad mico
Microphthalmia: MedlinePlus Genetics
Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies. Hum Mol Genet. 2010 Jan 15;19(2):287-98. ... Am J Med Genet A. 2004 Aug 15;129A(1):92-4. doi: 10.1002/ajmg.a.30126. No abstract available. Citation on PubMed ... 2009 Mar 15;18(6):1110-21. doi: 10.1093/hmg/ddp008. Epub 2009 Jan 6. Citation on PubMed ...
Bone Morphogenetic Protein 6 | Profiles RNS
"Bone Morphogenetic Protein 6" by people in this website by year, and whether "Bone Morphogenetic Protein 6" was a major or ... A bone morphogenetic protein that is a potent inducer of BONE formation. It plays additional roles in regulating CELL ... Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms. ... "Bone Morphogenetic Protein 6" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ...
Program - Hypertension Canada | For Healthcare Professionals
Examining the Impact of Endothelial Bone Morphogenetic Protein Receptor 2 Loss on Interleukin-15 Signaling and the Pathogenesis ... BM4 - Role of Stress Inducible Protein (STI-1) During Cardiac Development and Pathological Hypertrophy ... Transactivation of the Insulin Receptor through G-Protein-Coupled Receptor Biased Agonism: A Novel Therapeutic Target for ... Role of Giα Protein and Nitro-Oxidative Stress ... Protein Folding in Hypertension, Regulator of the Blood Vessel ...
Bone Morphogenetic Protein 4 | Colorado PROFILES
"Bone Morphogenetic Protein 4" by people in this website by year, and whether "Bone Morphogenetic Protein 4" was a major or ... A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation ... "Bone Morphogenetic Protein 4" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Masterson JC, Molloy EL, Gilbert JL, McCormack N, Adams A, ODea S. Bone morphogenetic protein signalling in airway epithelial ...
Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related...
Animals, Binding Sites, Bone and Bones, Bone Morphogenetic Protein 2, Cartilage, Core Binding Factor Alpha 3 Subunit, Core ... Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related ... Bone morphogenetic protein (BMP) 2 belongs to the transforming growth factor β (TGFβ) superfamily of cytokines and growth ... Proto-Oncogene Protein c-ets-1, Sea Bream, SOX9 Transcription Factor, Transcription Factors, Zebrafish Proteins. ...
HuGE Navigator|HuGE Literature Finder|PHGKB
FOXL2 - hpluswiki
... bone morphogenetic protein 15 (BMP15), forkhead transcription factor L2 (FOXL2), and growth differentiation factor-9 (GDF9)] ... Forkhead box protein L2 Publications[править]. Human amniotic mesenchymal stem cells improve ovarian function in natural aging ... measured by a protein antibody array methodology. After hAMSCs and hAECs were transplanted into a different degrees of POA ... were measured by a protein antibody array methodology. After hepatocyte growth factor (HGF) and epidermal growth factor (EGF) ...
Background The primary objective of today's work was to compare the | immune-source.com
Bone tissue morphogenetic proteins 15 (Mitotic arrest deficient-like 1 (didnt have any manifestation in either group, as ... proteins (NAIP) genes had been considerably upregulated in the GnRH-ant group set alongside the GnRH-a group, using the fold ... Ataxia telangiectasia and Rad3-related proteins and Ataxia telangiectasia mutated and the ones mixed up in cell routine ...
The TGFβ-miR200-MIG6 Pathway Orchestrates the EMT-Associated Kinase Switch That Induces Resistance to EGFR Inhibitors | Cancer...
... bone morphogenetic protein signaling through SMAD1/4 induces expression of proepithelial microRNAs (miRNA; miR200 and miR205) ... F, protein lysates were extracted from H358 cells treated with TGFβ1 or control vehicle for 21 days and immunoblot analysis was ... F, protein lysates were extracted from H358 cells treated with TGFβ1 or control vehicle for 21 days and immunoblot analysis was ... C. Protein lysates were extracted from H358 and SCC-S cells treated or untreated with TGFbeta for 21 days and immunoblot ...
Publications | GenPhySE
BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure<...
Bone morphogenetic protein 7 is an essential renal morphogen that maintains renal tubular differentiation in the adult and is ... Bone morphogenetic protein 7 is an essential renal morphogen that maintains renal tubular differentiation in the adult and is ... Bone morphogenetic protein 7 is an essential renal morphogen that maintains renal tubular differentiation in the adult and is ... Bone morphogenetic protein 7 is an essential renal morphogen that maintains renal tubular differentiation in the adult and is ...
A new role for sphingosine: Up-regulation of Fam20C, the genuine casein kinase that phosphorylates secreted proteins<...
Bone Morphogenetic Protein 15 Medicine & Life Sciences 18% View full fingerprint Cite this. * APA ... the genuine casein kinase that phosphorylates secreted proteins. Biochimica et Biophysica Acta - Proteins and Proteomics, 1854( ... the genuine casein kinase that phosphorylates secreted proteins, Biochimica et Biophysica Acta - Proteins and Proteomics, vol ... In: Biochimica et Biophysica Acta - Proteins and Proteomics, Vol. 1854, No. 10, 01.10.2015, p. 1718-1726.. Research output: ...
IMP: Integrative Multi-species Prediction
N-terminal EF-hand calcium binding protein 2. 0.014. Bmpr2. bone morphogenetic protein receptor, type II (serine/threonine ... guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1. 0.021. ... inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein. 0.011. ... a group of water-soluble proteins expressed in vary large quantities. ...
Temporal and spatial expression of bone morphogenetic proteins in extracorporeal shock wave-promoted healing of segmental...
Growth Differentiation Factor 6 | Harvard Catalyst Profiles | Harvard Catalyst
Chondroitin 4-Sulfate Covalently Cross-links the Chains of the Human ... - MOAM.INFO
Jan 31, 2012 - Genetic studies have identified bone morphogenetic protein-15 (BMP15) as an .... hBMP15 uses a complex of the ... which we designate a protein-glycosaminoglycan-protein (PGP) crosslink. A combination of protein and carbohydrate analytical ... The human blood protein pre-a-inhibitor is composed of one heavy and one light protein chain. The chains are covalently linked ... Nevertheless, we have recently shown (4) that the humanblood protein pre-a-inhibitor (PaI) consists of protein chains that ...
Animal Bioscience
Identification of sequence variation in the oocyte-derived bone morphogenetic protein 15 (BMP15) gene (BMP15) associated with ... Association Between PCR-SSCP of Bone Morphogenetic Protein 15 Gene and Prolificacy in Jining Grey Goats ... Association of a Single Codon Deletion in Bone Morphogenetic Protein 15 Gene with Prolificacy in Small Tail Han Sheep ...
Jason Northey | UCSF Profiles
Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced Breast Cancer Cell Migration and Invasion. Mol Cell Biol. 2016 ... Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)- ... 2013 Feb 15; 288(7):5210-22. Northey JJ, Dong Z, Ngan E, Kaplan A, Hardy WR, Pawson T, Siegel PM. PMID: 23277357; PMCID: ... 05 15; 36(10):1509-25. Cyr-Depauw C, Northey JJ, Tabariès S, Annis MG, Dong Z, Cory S, Hallett M, Rennhack JP, Andrechek ER, ...
Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism in bovine intervertebral disc...
Dive into the research topics of Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism ... T1 - Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism in bovine intervertebral disc ... Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism in bovine intervertebral disc ... Insulin-like growth factor 1 synergizes with bone morphogenetic protein 7-mediated anabolism in bovine intervertebral disc ...
Publications | GenPhySE
Advanced Biomedical Research: Browse articles
Original Article: Utilizing calcium alginate for the assessment of bone morphogenetic protein 15 induction effect on the ... Materials and Methods: In this study, the fusion protein (PlpE1 + 2 + 3) and full PlpE genes (PlpE-Total) were cloned in pET28a ... Original Article: PlpE epitopes of Pasteurella multocida fusion protein as novel subunit vaccine candidates. ... Patients in the intervention group, in addition to receiving routine treatment of control group (high-protein diet, resting), ...
BMP152021BMPsTissueSignaling pathwayRegeneration2022Receptor typeMesenchymalGene2018ReceptorsCellsCartilageBMP2InhibitionGraftGenesMRNA20172002AntibodyTumor2020MiceMutationsOsteoblastsPlatelet-rich plasmaInhibitorSupplProliferationGrowthDemineralized bone matrixCollagenPulmonary hypertensionSpineInducesSuperfamilyInhibitorsNogginRecombinant proteinsOsteoblastSpinalAutologousGraftsLiverSurgRegulationFormationFactorEfficacyInflammationKinaseFolliclePromotes
BMP154
- Bone morphogenetic protein 15 (BMP-15) is a protein that in humans is encoded by the BMP15 gene. (wikipedia.org)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Bone Morphogenetic Protein 15 (BMP15) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (lipidx.org)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Bone Morphogenetic Protein 15 (BMP15) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (lipidx.org)
- Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome (OHSS). (cdc.gov)
20215
- Indian Journal of Forensic Medicine & Toxicology 15, no. 4 (August 16, 2021): 1731-1737. (medicopublication.com)
- 2021) Elution of rifampin and vancomycin from a weight-bearing silorane-based bone cement. (kumc.edu)
- Parikh K, Reinhardt D, Templeton K, Toby B , Brubacher J . (2021) Rate of Bone Mineral Density Testing and Subsequent Fracture-Free Interval After Distal Forearm Fracture in the Medicare Population. (kumc.edu)
- Meng B, Bunch J , Burton D, Wang J . (2021) Lumbar interbody fusion: recent advances in surgical techniques and bone healing strategies. (kumc.edu)
- 2021 May;15(3):410-419. (koreamed.org)
BMPs11
- Bone morphogenetic proteins (BMPs) have been considered for bone graft enhancement. (e-neurospine.org)
- Bone morphogenetic proteins (BMPs) are progress components that belong to the remodeling progress factor-β (TGF-β) superfamily, and until date 15 BMPs have been described. (eb2009.org)
- BMPs, first described for his or her function in bone and cartilage formation, additionally play a task in renal fibrosis in persistent kidney illness (CKD). (eb2009.org)
- BACKGROUND: Bone morphogenetic proteins (BMPs) are also called growth and differentiation factors (GDFs) and form a subfamily of related proteins within the TGF-beta superfamily. (who.int)
- The interplay between bone morphogenetic proteins (BMPs) and their antagonists governs developmental and cellular processes as diverse as establishment of the embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. (nature.com)
- Recently it was demonstrated that ossification are due to increased expression of BMP-2 and BMP-4, a member of the bone morphogenetic proteins (BMPs). (fapesp.br)
- There are many mediators involved in the differentiation process osteogenic that seek to repair and form bone tissue, some of these mediators are the Bone morphogenetic proteins (BMPs). (fapesp.br)
- So we're going to go through its inflammatory modulating effects of what's called BMPs, which I'm going to refer to pretty frequently throughout the presentation, that's called bone morphogenetic proteins. (chiroeco.com)
- I will go through these BMPs and their stem cell signaling pathway, and then we're going to talk about just principles of bone and cartilage. (chiroeco.com)
- [ 5 ] BMPs are members of the transforming growth factor-beta superfamily and play a role in the development of bone and other tissues. (medscape.com)
- Limited on behalf of the Biochemical Society 2016 bone morphogenetic protein (BMP) signalling cancer small molecule BMP inhibitors Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) family. (silverchair.com)
Tissue31
- BMP-15 is released from the oocyte into the surrounding granulosa tissue where it binds to two membrane bound receptors on granulosa cells. (wikipedia.org)
- Limb hypertrophy is due to the presence of vascular, venous, and lymphatic abnormalities but also to the hypertrophy of soft tissue and bone. (medscape.com)
- Bone tissue morphogenetic proteins 15 (Mitotic arrest deficient-like 1 (didn't have any manifestation in either group, as offered in Desk?4. (immune-source.com)
- It is generally assumed that these cross-links impart structural rigidity to fibrin and connective tissue proteins. (moam.info)
- However, noncalcium phosphate-based bone substitutes demonstrate poor mechanical properties, low biocompatibility, and poor tissue adhesion. (e-neurospine.org)
- After publication of the results gained for the regulators of cartilage metabolism bFGF and IGF-I [ 3 ], this article focuses on the role of the Bone morphogenetic proteins 2 and 7 (BMP-2, BMP-7) that both are recognized as candidate growth factors with good potential in cartilage tissue engineering as well as cartilage repair. (biomedcentral.com)
- BMP-4 is one ofmultifuntional growth factors with pleiotropic roles in many different cell types and is predominantly present in human bone tissue. (who.int)
- Bone is a dynamic tissue, constantly refurbished, which depends on several factors to maintain the balance between bone formation and resorption. (fapesp.br)
- Bone tissue is affected by several injuries, including congenital factors, metabolic diseases as well as factors external such as fractures. (fapesp.br)
- In addition, the main goal is to develop a therapy in which formation bone is modulated inflammation of bone tissue. (fapesp.br)
- The principles of guided tissue and bone regeneration are covered in detail, including many recent advancements in barrier membrane technologies as well as use of platelet-rich fibrin and various growth factors, and many next-generation materials that will optimize future bone and periodontal regeneration are presented. (thinkbetter.pro)
- Today's webinar, "Breakthrough in Stem Cell Activation: The First Oral Protein Complex for Tissue Regeneration. (chiroeco.com)
- The release of growth factors further accelerates the bone regeneration process by promoting the migration, proliferation, and differentiation of mesenchymal stem cells and other bone progenitor cells from surrounding tissue. (tobig.eu)
- GDF15 can be known as macrophage inhibitory cytokine-1 (MIC-1), prostate-derived element (PDF), placental bone tissue morphogenetic proteins (PLAB), placental changing growth element (PTGF), and non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) [94]. (cp-724714.com)
- Adipose-derived stem cells (ADSCs) are a promising cell source in regenerative medicine, of particular utility for cell therapies and tissue engineering, because adipose tissue can easily be harvested in large quantities compared to bone marrow, and ADSCs have high proliferation rates in culture. (ncu.edu.tw)
- Local delivery of BMSCs onto a bone scaffold associated with bone formation in vivo confirmed the preferential tropism of BMSCs to the bone tissue as well as their efficacy to form bone. (biomedcentral.com)
- As bone is the physiological environment of BM-MSCs (BMSCs), we hypothesized that a local delivery of BMSCs into the FH during surgery would facilitate their location and participation in tissue regeneration. (biomedcentral.com)
- although clinically efficacious, some common risks of the use of rhBMP-2 in patients include heterotopic bone formation and life-threatening soft tissue swelling, resulting in airway obstruction in the setting of anterior cervical fusion. (ijssurgery.com)
- The Bone tissue Morphogenetic Protein (BMP) are secreted ligands mainly known for his or her functional roles in embryogenesis and tissue development. (bioinf.org)
- and matrix-regulative genes, including matrix metalloproteinase-13, tissue-inhibitor of matrix metalloproteinase-1, and bone morphogenetic protein (BMP)-2. (nih.gov)
- Early in his career, he worked on tissue biology of infectious diseases, biofilm-induced bone diseases and antibody engineering. (jcvi.org)
- In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (bio-techne.com)
- Lee have shown an increase in MAP1LC3B\II protein levels in lung tissue from iPAH patients compared with controls 24. (leafbioscience.com)
- The pathway helps regulate growth and development of bone and other tissue. (stjude.org)
- In diabetic nephropathy, connective tissue growth factor (CTGF) is upregulated and bone morphogenetic protein 7 (BMP-7) is downregulated. (asnjournals.org)
- Immunofluorescence staining for bone specific proteins in cell seeded scaffolds tissue sections confirmed differentiation of the cells into osteoblasts in vivo . (biomedcentral.com)
- The results demonstrate that TGF-beta family of proteins could potentially be used to generate murine iPSC derived-cells with potential for osteoblasts differentiation and bone formation in vivo and thus for application in musculoskeletal tissue repair and regeneration. (biomedcentral.com)
- As a scaffold, most present graft biomaterials are able to osteoconduct matrix or three-dimensional substrates to support new bone tissue formation [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ] . (oapublishinglondon.com)
- The manufacturing production of scaffolds with ideal characteristics is one of the most challenging issues in bone tissue regeneration strategy. (oapublishinglondon.com)
- The main purpose of this paper is to show the possible applications of microtomography for 3D inner displaying and morphometric characterization of a human bone tissue grafted with an osteoconductive biomaterial. (oapublishinglondon.com)
- The regenerated bone tissue of the test sample was analysed by means of 3D microtomographic and histological tests, and the results were compared with those obtained from similar evaluations carried out on the control sample. (oapublishinglondon.com)
Signaling pathway7
- Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human. (atlasgeneticsoncology.org)
- The ST2 cells were cultured with SP, Noggin (inhibitor of the bone morphogenetic protein signaling pathway), SP+Noggin, and 2% fetal bovine serum, respectively. (hxkqyxzz.net)
- Conclusion SP can promote the proliferation and osteogenic differentiation of ST2 cells, and the bone morphogenetic protein signaling pathway may be involved in this process. (hxkqyxzz.net)
- Role of neuropeptide substance P and the bone morphogenetic protein signaling pathway in osteogenic differentiation of ST2 cells[J]. West China Journal of Stomatology, 2018, 36(4): 378-383. (hxkqyxzz.net)
- Findings suggest that fibrodysplasia ossificans progressiva maps to band 4q27-31, a region that contains at least 1 gene involved in the bone morphogenic protein (BMP) signaling pathway. (medscape.com)
- A signaling pathway called Hedgehog signaling is overactive in human cartilage and bone tumors. (elifesciences.org)
- APC protein down-regulates the Wnt signaling pathway through its binding to β-catenin and axin ( 8 ). (cdc.gov)
Regeneration13
- Masterson JC, Molloy EL, Gilbert JL, McCormack N, Adams A, O'Dea S. Bone morphogenetic protein signalling in airway epithelial cells during regeneration. (ucdenver.edu)
- Objective: We undertook this study to assess the therapeutic benefits of intervertebral disc matrix repair and regeneration by evaluating the potential synergistic effect of insulin-like growth factor 1 (IGF-1) and bone morphogenetic protein 7 (BMP-7) on bovine spine discs and by elucidating the relevant molecular/cellular mechanisms. (elsevier.com)
- 2 day lecture titled Next Generation Biomaterials for Bone and Periodontal Regeneration in affiliation with the NSU Implant Maxi Program. (themironlab.com)
- Next-Generation Bone Morphogenetic Protein 9: The Future of Bone Regeneration? (thinkbetter.pro)
- This study was to clarify whether HA-g-CS and moderate-intensity exercise might have a synergistic effect on facilitating (1) regeneration of osteochondral defects and (2) subchondral bone remodeling in a mouse model of osteochondral defects. (medsci.org)
- The ability of P-15 to enhance cell binding, increases the number of viable cells at the healing site and speeds the process of new bone formation, and closely resembles the natural process of bone regeneration. (tobig.eu)
- Thus, skeletal stem cells recruited locally at the bone fracture site promote healing and their ablation disrupts bone regeneration and remodelling [18]. (tobig.eu)
- BMSC efficacy on bone regeneration was evaluated by magnetic resonance imaging (MRI) and histology. (biomedcentral.com)
- Genetic and pharmacologic suppression of PPARγ enhances NELL-1-stimulated bone regeneration. (ucla.edu)
- PRP did not enhance bone regeneration. (annals.edu.sg)
- Isolation of pig bone marrow mesenchymal stem cells suitable for one-step procedures in chondrogenic regeneration. (tissue-regeneration.at)
- Bone healing is a quite complex and dynamic process that dates back to embryonic bone development and regeneration, and ends with the restoration of anatomical and functional standard conditions of the bone. (oapublishinglondon.com)
- Since its inception in 1997, Citagenix has become an important source of knowledge and experience for bone regeneration in the Canadian medical device industry. (antibethera.com)
20221
- 2022.1.Hs: Updated to GO Release 2022-07-01, NCBI gene2go 2022-07-15. (gsea-msigdb.org)
Receptor type5
- Rationale: Idiopathic pulmonary arterial hypertension (IPAH) is usually without an identified genetic cause, despite clinical and molecular similarity to bone morphogenetic protein receptor type 2 mutation-associated heritable pulmonary arterial hypertension (PAH). (northwestern.edu)
- Fatty Acid Metabolism, Bone Morphogenetic Protein Receptor Type 2, and the Right Ventricle. (ucdenver.edu)
- Mutations of the bone morphogenetic protein receptor type II gene ( BMPR2), a component of the transforming growth factor beta (TGF-β) family which plays a key role in cell growth, have recently been identified as causing familial PPH. (bmj.com)
- 7-11 Mutations in the bone morphogenetic protein receptor type II gene ( BMPR2 ), a receptor member of the transforming growth factor beta (TGF-β) family, have recently been identified as causing FPPH. (bmj.com)
- Importantly, E12.5 equatorial lens vesicle cells showed cell-surface immunoreactivity for bone-morphogenetic protein receptor type 2 and nuclear immunoreactivity for the active, phosphorylated form of the Bmp responsive Smads. (silverchair.com)
Mesenchymal9
- BMP-2 and insulin-like growth factor-I mediate Osterix (Osx) expression in human mesenchymal stem cells via the MAPK and protein kinase D signaling pathways. (atlasgeneticsoncology.org)
- Bone morphogenetic protein 2, a growth factor that commits mesenchymal progenitor cells to differentiate into osteoblasts, down-regulated rHox mRNA expression by 40-50% in UMR 201, a rat preosteoblast cell line, in a time- and dose-dependent manner. (garvan.org.au)
- Objective This study aimed to investigate the role and mechanism of neuropeptide substance P (SP) in ST2 cell (bone mesenchymal stem cells of mice) osteogenic differentiation to provide a basis for the treatment of temporomandibular joint osteoarthritis. (hxkqyxzz.net)
- A thermoresponsive polydiolcitrate-gelatin scaffold and delivery system mediates effective bone formation from BMP9-transduced mesenchymal stem cells. (wjgnet.com)
- Argonaute (AGO) proteins play an essential role in mediating BMP9-induced osteogenic signaling in mesenchymal stem cells (MSCs). (wjgnet.com)
- Injection of osteoprogenitor cells like bone marrow mesenchymal stromal cells (BMSCs) into the FH appears to be a good therapeutic treatment. (biomedcentral.com)
- Besides their inhibitory effect on osteoclasts and bone resorption, bisphosphonates may promote the processes of bone formation and enhance osteogenic differentiation of mesenchymal stem cells (MSCs) [ 17 ]. (biomedcentral.com)
- report that deleting Ptch1 in mesenchymal stem cells, early-stage cells that can give rise to cartilage and bone cells, generates a mouse model for osteosarcoma and cartilage tumors. (elifesciences.org)
- Treating the mice that had mesenchymal cells lacking Ptch1 with a drug that inhibits Wnt signaling reduced the growth of cartilage and bone tumors. (elifesciences.org)
Gene12
- The BMP-15 gene is located on the X-chromosome and using Northern blot analysis BMP-15 mRNA is locally expressed within the ovaries in oocytes only after they have started to undergo the primary stages of development. (wikipedia.org)
- Two breeds of sheep, Inverdale and Hanna, are naturally heterozygous carriers of point mutations in the BMP-15 gene. (wikipedia.org)
- Data reported here provides new insights toward the better understanding of the transcriptional regulation of BMP2 gene in a bone and cartilage context. (ualg.pt)
- Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure. (princeton.edu)
- CONCLUSION The sporadic form of PPH is associated with germline mutations of the gene encoding the receptor protein BMPR-II in at least 26% of cases. (bmj.com)
- An animal model of degeneration was used to determine the effects of disc distraction, and was evaluated with magnetic resonance imaging (MRI) as well as gene and protein expression levels. (nih.gov)
- Distraction results in disc rehydration, stimulated extracellular matrix gene expression, and increased numbers of protein-expressing cells. (nih.gov)
- Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. (vanderbilt.edu)
- Although the amount of BMP-7 mRNA was similar in the kidneys of diabetic CTGF +/+ and CTGF +/− mice, phosphorylation of the BMP signal transduction protein Smad1/5 and expression of the BMP target gene Id1 were lower in diabetic CTGF +/+ mice. (asnjournals.org)
- but mice do not form tumors when this gene is deleted in their mature cartilage and bone cells. (elifesciences.org)
- Phenotypic and physiological novelty in snakes seems to be driven by system-wide coordination of protein adaptation, gene expression, and changes in the structure of the genome. (lstmed.ac.uk)
- The adenomatous polyposis coli ( APC ) gene is a tumor suppressor gene, and mutations resulting in loss of APC protein function are associated with carcinogenesis. (cdc.gov)
20181
- 2018 Mar 15;114(4):551-564. (ucdenver.edu)
Receptors4
- Creating models animal FOP from the knockout mice to kinin receptors allow us clarify the role of inflammation in ectopic bone formation, found in this disease.Thus, with the generated models, it is possible to evaluate the role of kinins in osteogenesis mediated BMP-2. (fapesp.br)
- However, attachment as well as stable adhesion can also be mediated by specific, high affinity receptor-ligand interactions, e.g., between cell surface receptors like integrins and their ECM binding partner(s) on the substratum [15-16]. (tobig.eu)
- G-protein receptors regulation of inflammatory response. (jcvi.org)
- Miyazono K, Kamiya Y, Morikawa M. Bone morphogenetic protein receptors and signal transduction. (eurekaselect.com)
Cells28
- BMP-15 prevents this transition by inhibiting the production of FSH receptor mRNA in granulosa cells. (wikipedia.org)
- As BMP-15 acts directly on granulosa cells it has an important influence on granulosa function including steroidogenesis inhibition of luteinization and differentiation of cumulus, without which would lead to infertility and lack of folliculogenesis. (wikipedia.org)
- Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. (atlasgeneticsoncology.org)
- Wahdan-Alaswad RS, Song K, Krebs TL, Shola DT, Gomez JA, Matsuyama S, Danielpour D. Insulin-like growth factor I suppresses bone morphogenetic protein signaling in prostate cancer cells by activating mTOR signaling. (ucdenver.edu)
- The Bone Morphogenetic Protein 15 Up-Regulates the Anti-Müllerian Hormone Receptor Expression in Granulosa Cells. (inra.fr)
- 2013) Vascular endothelial growth factor-A signaling in bone marrow-derived endothelial progenitor cells exposed to hypoxic stress. (wisc.edu)
- Expression of rHox mRNA in calvarial osteoblasts derived from PTHrP -/- mice was approximately 15% of that observed in similar cells obtained from normal mice. (garvan.org.au)
- Furthermore, research indicates that P-15 promotes the attraction, attachment, proliferation and differentiation of cells. (tobig.eu)
- Salisbury E.A, Lazard Z.W., Ubogu E.E., Davis A.R., Olmsted-Davis E.A. Transient brown adipocyte-like cells derive from peripheral nerve progenitors in response to bone morphogenetic protein 2. (utmb.edu)
- A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS. (musc.edu)
- Mei G, Zou Z, Fu S, et al.Substance P activates the Wnt signal transduction pathway and enhances the differentiation of mouse preosteoblastic MC3T3-E1 cells[J]. Int J Mol Sci, 2014, 15(4): 6224-6240. (hxkqyxzz.net)
- This protein segment (P-15) is responsible for the attachment and proliferation of osteogenic cells. (tobig.eu)
- These cells bind to the synthetic P-15 found in i-FACTOR the same way they would bind to human Type I collagen (figure 1). (tobig.eu)
- i-FACTOR Bone Graft increases the opportunity for cell binding in the fusion site by making an abundance of the P-15 peptide available to osteogenic cells. (tobig.eu)
- Cells have a natural high affinity for P-15 which increases the number of viable cells at the healing site. (tobig.eu)
- Studies demonstrated that on P-15-coated substrata, increased cell spreading and lamellipodia and filopodia formation was observed by 30 min and remained obvious even days later in comparison with those cells cultured on control substrata [6, 9,20]. (tobig.eu)
- Stable sites of cell-substratum adhesion may then transition to become focal adhesions which are platforms for cell activation and signaling [21-22]From three hours through four days after the onset of cell attachment to P-15-coated substrata, those cells were more viable and showed less apoptosis (programmed cell death), compared with cells on control substrata. (tobig.eu)
- Overexpression of EIF5A2 in CRC cells enhances the enrichment of c-Myc around the promoter of metastasis-associated proteins 1 (MTA1). (cp-724714.com)
- Under hypoxia, dexamethasone treatment inhibits HIF-1 proteins levels and reduces mRNA degrees of hypoxia-induced SNAIL, SLUG, and TWIST1, and transcriptional elements involved with EMT, aswell as the hypoxia-induced integrin V6 proteins, a well-known EMT marker for CRC cells [102]. (cp-724714.com)
- Porcine allograft mandible revitalization using autologous adipose-derived stem cells, bone morphogenetic protein-2, and periosteum. (uc.edu)
- Morpholino-based knockdown of Eya1 leads to reduction of proliferating, Sox3- and Islet1/2-immunopositive cells, redistribution of cell polarity proteins and loss of N-cadherin suggesting that Eya1 is required for maintenance of epithelial cells with apicobasal polarity, progenitor proliferation and neuronal differentiation during otic neurogenesis. (frontiersin.org)
- iPSC\ECs, human pulmonary artery endothelial cells (PAECs), human pulmonary artery easy muscle cells (PASMCs), inflammation, pulmonary arterial hypertension (PAH) Introduction Pulmonary arterial hypertension (PAH) is usually characterised by an increase in mean pulmonary arterial pressure (greater than 25?mmHg at rest), pulmonary capillary wedge pressure (15?mmHg), and pulmonary vascular Isorhamnetin 3-O-beta-D-Glucoside resistance (greater than 3 Wood units) 1. (leafbioscience.com)
- More targeted sequencing of additional tumors was conducted to track how instructions encoded in DNA were translated into the proteins that do the work of cells. (stjude.org)
- TGF-β1 in combination with RA derived-cells seeded onto HA/TCP ceramics and implanted in mice deposited typical bone. (biomedcentral.com)
- The cartilage and bone tumors are originated from Prrx1 + lineage cells and express low levels of osteoblast and chondrocyte markers, respectively. (elifesciences.org)
- These findings suggest that cartilage/bone tumors arise from their early progenitor cells and identify the Wnt/β-Catenin pathway as a pharmacological target for cartilage/bone neoplasms. (elifesciences.org)
- The mice with these Ptch1 deficient cells developed tumors with overactive Hedgehog signaling in cartilage and bone. (elifesciences.org)
- In vivo testing demonstrates all five elements of bone formation are present in our PentOS OI™ grafts: chondrocytes, osteocytes, bone marrow cells, cartilage, and new bone. (antibethera.com)
Cartilage13
- While it plays important roles in embryo morphogenesis and organogenesis, BMP2 is also critical to bone and cartilage formation. (ualg.pt)
- In silico analysis of seabream BMP2 promoter revealed several binding sites for bone and cartilage related transcription factors (TFs) and their functionality was evaluated using promoter-luciferase constructions and TF-expressing vectors. (ualg.pt)
- A bone morphogenetic protein that may play a role in CARTILAGE formation. (ouhsc.edu)
- It is a potent regulator of the growth of CHONDROCYTES and the synthesis of cartilage matrix proteins. (ouhsc.edu)
- Evidence for its role in cartilage formation can be seen in MICE, where genetic mutations that cause loss of bone morphogenetic protein 5 function result in the formation of small malformed ears. (ouhsc.edu)
- Substantial evidence shows that crosstalk between cartilage and subchondral bone may play an important role in cartilage repair. (medsci.org)
- However, no in vivo studies have demonstrated that these two factors may have a synergistic activity to facilitate subchondral bone remodeling in mice, thus supporting bone-cartilage repair. (medsci.org)
- Extent of subchondral bone remodeling at the injury site and subsequent cartilage repair were assessed at 4 weeks after surgery. (medsci.org)
- The extent of cartilage repair was correlated positively to bone formation activity at the injured site as verified by microCT and correlation analysis. (medsci.org)
- This bone formation process was accompanied by an increase in osteogenesis and chondrogenesis factors at the injury site which promoted cartilage repair. (medsci.org)
- Also, cartilage and subchondral bone forms a functional unit in an articular joint and subchondral bone may regulate cartilage repair by secreting growth factors in its remodeling process. (medsci.org)
- Indian Hedgehog (IHH) signaling, a key regulator of skeletal development, is highly activated in cartilage and bone tumors. (elifesciences.org)
- Bone and cartilage tumors are among the most common tumors in the skeleton, often affecting the limbs. (elifesciences.org)
BMP23
- Protein structure and function have been remarkably conserved throughout evolution and BMP2 transcription has been proposed to be tightly regulated, although few data is available. (ualg.pt)
- In an effort to understand the function of this variant protein, we generated a mouse line in which BMP2 is expressed and functions normally, but nBMP2 is excluded from the nucleus. (hindawi.com)
- Had it entered the secretory pathway, the protein would have been cleaved at a furin-type proprotein convertase recognition sequence to release the mature BMP2 growth factor. (hindawi.com)
Inhibition3
- DMH1 has been used for bone morphogenetic protein (BMP) inhibition. (sigmaaldrich.com)
- Bisphosphonates are antiresorptive drugs that influence bone metabolism mainly via inhibition of osteoclast recruitment, differentiation, and bone resorption activity [ 13 ]. (biomedcentral.com)
- Ligand (Indian, Sonic, or Desert Hedgehog) engagement to receptor Smoothened (Smo) relieves the inhibition of Patched 1 (Ptch1) and upregulates Gli1/2 proteins, which increase the expression of proteins including Myc, Cyclin D, and Bcl2 and promote cell proliferation. (elifesciences.org)
Graft10
- Therefore, HA is preferred as a bone graft or extender in orthopedics [ 8 - 11 ]. (e-neurospine.org)
- i-FACTOR Peptide Enhanced Bone Graft is based upon the biological activity of a 15 amino-acid peptide found in type I collagen. (tobig.eu)
- We hypothesized locally delivered ascorbic acid and β-glycerophosphate act as a bone graft extender to increase the volume of new bone formed in a murine model of posterior lumbar fusion. (ijssurgery.com)
- Fresh morselized bone graft from 12 donor mice was used. (ijssurgery.com)
- 1 - 3 An additional $2 billion is spent on products to augment iliac crest autograft and local bone graft with bone graft extenders or substitutes, such as demineralized bone matrix, ceramics, and bone morphogenetic proteins. (ijssurgery.com)
- Graft resorption with the use of bone morphogenetic protein: lessons from anterior lumbar interbody fusion using femoral ring allografts and recombinant human bone morphogenetic protein-2. (ucdenver.edu)
- [1] Additional hardware (screws, plates, or cages) is often used to hold the bones in place while the graft fuses the two vertebrae together. (wikipedia.org)
- Demineralized dentin matrix (DDM) is commonly used as a bone-graft substitute. (biomedcentral.com)
- Demineralized dentin matrix (DDM) is one of the most acid-insoluble collagenous scaffolds containing minerals and noncollagenous proteins (NCPs) such as bone morphogenetic protein (BMP) and is now commonly used as a bone-graft substitute. (biomedcentral.com)
- For using DDM as an allogenic bone-graft substitute, the risk of viral-disease transmission should be reduced or eliminated. (biomedcentral.com)
Genes7
- proteins (NAIP) genes had been considerably upregulated in the GnRH-ant group set alongside the GnRH-a group, using the fold switch of 3.990 (SD 1.325), 6.274 (SD 1.542), and 2.156 (SD 1.443), respectively, (P 0.001). (immune-source.com)
- Real-time polymerase chain reaction (PCR) and immunofluorescence (ICC) staining method were performed to characterize the expression of OCT4, Nanog, ZP2, and ZP3 genes and protein. (advbiores.net)
- Thus far attempts to discover major autism susceptibility genes have been largely unsuccessful, with approximately only 15% to 20% of cases of autism linked to specific genes, chromosomal aneuploidy or recognized syndromes [ 2 - 4 ]. (biomedcentral.com)
- Results and Conclusions: During in vitro hypertrophic differentiation, levels of p57 mRNA and protein were constant despite changes in chondrocyte proliferative activity and the induction of hypertrophic-specific genes in response to bone morphogenetic protein (BMP)-2. (illinois.edu)
- of the manifestation of 25 genes involved in angiogenesis/tumor invasion and 15 housekeeping genes. (bioinf.org)
- In the early Xenopus embryo, the Xiro homeodomain proteins of the Iroquois (Iro) family control the expression of proneural genes and the size of the neural plate. (biologists.com)
- We also found that many snake metabolic genes have undergone positive selection, which together with the rapid evolution of mitochondrial proteins, provides evidence for extensive adaptive redesign of snake metabolic pathways. (lstmed.ac.uk)
MRNA4
- Furthermore, down-regulation of rHox mRNA by bone morphogenetic protein 2 and its up-regulation by PTHrP support a role of the homeodomain protein, rHox, in osteoblast differentiation. (garvan.org.au)
- Protein and mRNA levels were monitored by Western and Northern blot analyses, respectively. (illinois.edu)
- Compared with diabetic wild-type CTGF +/+ mice, diabetic CTGF +/− mice had approximately 50% lower CTGF mRNA and protein, less severe albuminuria, no thickening of the glomerular basement membrane, and preserved matrix metalloproteinase (MMP) activity. (asnjournals.org)
- The renal expression of CTGF mRNA and protein is upregulated in human and experimental diabetic nephropathy. (asnjournals.org)
20172
- 2017 Jun 15;198(12):4802-4812. (ucdenver.edu)
- 2017 Oct 15;196(8):1075-1077. (ucdenver.edu)
20021
- Development (2002) 129 (15): 3727-3737. (silverchair.com)
Antibody2
- Cytokines (growth factors) were measured by a protein antibody array methodology. (transhumanist.ru)
- Using an antibody specifically raised against Xenopus Eya1, we characterize the subcellular localization of Eya1 proteins, their levels of expression as well as their distribution in relation to progenitor and neuronal differentiation markers during otic neurogenesis. (frontiersin.org)
Tumor3
- Osteosarcoma is the most common malignant bone tumor, which accounts for about one third of all bone malignancies. (alliedacademies.org)
- Treatment of metastatic Ewing sarcoma/primitive neuroectodermal tumor of bone: evaluation of increasing the dose intensity of chemotherapy--a report from the Children's Oncology Group. (childrenshospital.org)
- Recent research have proven that spindle and kinetochore-associated protein 2 (SKA2) is dysregulated in a number of tumors and acts as a key regulator of tumor development. (wntproteins.com)
20201
- Toxicol Rep. 2020 Feb 15;7:386-402. (nih.gov)
Mice4
- In mice, the BMP-15 homologue is not as physiologically important. (wikipedia.org)
- Uremia was imposed on LDL receptor null mice (a model of atherosclerosis), which were then treated with bone morphogenetic protein 7 for 15 wk. (wustl.edu)
- Shen K, Liu X, Qin H, Chai Y, Wang L, Yu B. HA-g-CS Implant and Moderate-intensity Exercise Stimulate Subchondral Bone Remodeling and Promote Repair of Osteochondral Defects in Mice. (medsci.org)
- Because no bone formation occurs in Osterix null mice, Osterix is thought to be an essential regulator of osteoblast differentiation. (ub.edu)
Mutations5
- These point mutations result in higher ovulation rates and larger litter sizes than sheep strains with a wildtype BMP-15 genotype. (wikipedia.org)
- Sheep carrying homozygous alleles for the Inverdale and Hanna BMP-15 mutations are infertile, as they have streak ovaries and the primary stage of folliculogenesis is inhibited. (wikipedia.org)
- The classification of PAH comprises non\hereditary or idiopathic PAH (iPAH) and hereditary PAH, which is mostly related to heterozygous germline mutations in encodes for the bone morphogenetic protein (BMP) type 2 receptor, which belongs to the transforming growth factor (TGF\) family. (leafbioscience.com)
- Despite the above, the incomplete penetrance of mutations (20C30%) suggests that other genetic and environmental factors such as hypoxia, inflammation 11, 12, 13, 14, 15, alterations in oestrogen metabolism 16, 17, or infections 18 contribute to the disease. (leafbioscience.com)
- In individuals with an inherited disorder called fibrodysplasia ossificans progressiva (FOP), the same ACVR1 mutations lead not to cancer, but to a different mechanism resulting in abnormal growth of bone in other tissues. (stjude.org)
Osteoblasts2
- P-15 also improves cell viability and the receptor-mediated anchorage of osteoblasts by P-15 initiates a number of signal transduction pathways that lead to the synthesis of growth factors, cytokines, and bone morphogenetic proteins. (tobig.eu)
- Osterix, a zinc-finger transcription factor, is specifically expressed in osteoblasts and osteocytes of all developing bones. (ub.edu)
Platelet-rich plasma4
- Platelet Rich Plasma: A source of multiple autologous growth factors for bone grafts. (thieme-connect.com)
- The use of Platelet-Rich Plasma to Enhance the Sucess of Bone Grafts Around Dental Implants. (thieme-connect.com)
- Bone grafting the jaws in the 21st century: The use of platelet-rich plasma and bone morphogenetic protein. (thieme-connect.com)
- The biomaterials used for calvarial reconstruction were demineralised perforated bone matrix (DBM), recombinant human bone morphogenetic protein-2 (rhBMP2) and autogenous platelet-rich plasma (PRP). (annals.edu.sg)
Inhibitor6
- The human blood protein pre-a-inhibitor is composed. (moam.info)
- The human blood protein pre-a-inhibitor is composed of one heavy and one light protein chain. (moam.info)
- Nevertheless, we have recently shown (4) that the humanblood protein pre-a-inhibitor (PaI)' consists of protein chains that contain a carbohydrate cross-link. (moam.info)
- Embryonic mouse models have demonstrated that ROCK protein inhibitor decreases the number of terminal lung buds. (medscape.com)
- Selective serotonin re-uptake inhibitor sertraline inhibits bone healing in a calvarial defect model. (musc.edu)
- DMH1 is a highly selective Bone morphogenetic protein (BMP) inhibitor. (sigmaaldrich.com)
Suppl1
- 2007;15 Suppl 1:S5-7. (childrenshospital.org)
Proliferation2
- The P-15 peptide in i-FACTOR is immobilized on an anorganic bone mineral (ABM) surface and enhances cell adhesion and migration, and induces osteoblast cell proliferation and differentiation. (tobig.eu)
- The advantageous stability between proliferation, differentiation, and apoptosis in the colonic epithelium is tightly managed by the interaction between WNT, Notch, and bone morphogenetic protein (BMP) signaling. (wntproteins.com)
Growth15
- This protein is a member of the Transforming growth factor beta (TGF-β) superfamily and is a paracrine signalling molecule. (wikipedia.org)
- Functions of BMP-15 include Promotion of growth and maturation of ovarian follicles, starting from the primary gonadotrophin-independent phases of folliculogenesis. (wikipedia.org)
- Bone morphogenetic protein (BMP) 2 belongs to the transforming growth factor β (TGFβ) superfamily of cytokines and growth factors. (ualg.pt)
- Medtronic Inc. (MDT) ghost-wrote sections of medical papers and paid physician authors hundreds of millions of dollars in 'consulting fees' to promote its bone-growth product Infuse, a U.S. Senate investigation found. (news-medical.net)
- Medtronic, the world's biggest maker of heart-rhythm devices, helped write, edit and shape at least 11 medical journal articles about the product, which is used to spur bone growth after spinal surgery, according to report released today by the Senate Finance Committee (Cortez and Armstrong, 10/25). (news-medical.net)
- Transforming growth factor family proteins like TGFß1 can oppose these effects. (medscape.com)
- Enhanced expression of growth factor beta 1 (TGF-B1), bone morphogenetic protein 2 (BMP-2) and BMP-7 hours-days after cell attachment to P-15 coated surfaces was shown. (tobig.eu)
- 您现在的位置: 主页 / 其他重组蛋白 / Recombinant Human Growth Differentiation Factor 5/Bone Morphogenetic Protein-14. (watson-bio.cn)
- Growth/differentiation factors (GDF-1 to GDF-15) are members of the BMP family of TGF-beta superfamily proteins. (watson-bio.cn)
- Much like one implant size and shape cannot be utilized for every indication in implant dentistry, one bone grafting material, barrier membrane, or growth factor cannot maximize regenerative outcomes in all clinical situations. (thinkbetter.pro)
- Children in remote areas often suffer from inadequate intake of protein and trace elements such as zinc and iron due to economic reasons, resulting in growth retardation, low weight and anemia. (magtech.com.cn)
- Turning the growth hormone receptor on: evidence that hormone binding induces subunit rotation[J]. Proteins, 2010,78(5):1163-1174. (magtech.com.cn)
- The successful separation of a pair of craniopagus twins resulted in significant cranial vault defects that required reconstruction.1 Previously, calvarial reconstruction in separated craniopagus twins was postponed until adolescence when autologous bone was more plentiful.2 The goals of pediatric calvarial reconstruction are to provide protection for the brain, to enable normal growth of the cranial vault and to reduce deformity of the head shape. (annals.edu.sg)
- iPSC reprogrammed from murine tail tip fibroblasts were exposed to retinoic acid alone (RA) or in combination with TGF-β1 and 3, basic fibroblast growth factor (bFGF) or bone morphogenetic protein 2 (BMP-2). (biomedcentral.com)
- BMP is a naturally occurring growth factor found in the human body and plays a crucial role in bone formation. (antibethera.com)
Demineralized bone matrix2
- RESULTS: 63 samples of demineralized bone matrix (DBM) derived from 36 men and 27 women between the ages of 15-65 years. (who.int)
- The processing of bone to produce demineralized bone matrix (DBM) entails conditions harsh enough to achieve significant levels of viral inactivation. (biomedcentral.com)
Collagen7
- Schematic illustrating the organic phase of bone, comprised of rope-like collagen macromolecules, their component triple helices, and P-15, a 15 amino acid peptide present within single chains of the triple helices. (tobig.eu)
- The P-15 sequence (residues 769-783) comprises about one per cent of the length of the collagen molecule. (tobig.eu)
- A second "sponge control" group received morselized bone with the control collagen sponge. (ijssurgery.com)
- The third group received morselized bone and a collagen sponge with ascorbic acid and β-glycerophosphate. (ijssurgery.com)
- Ascorbic acid, or vitamin C, and its role in bone synthesis have been studied since the discovery of scurvy, 9 and it has been involved in the collagen biosynthetic pathway 10 and upregulates alkaline phosphatase. (ijssurgery.com)
- The annulus is formed of 15-25 concentric lamellae with collagen fibers running parallel within each lamella and oriented approximately 60° to the vertical axis. (wheelessonline.com)
- Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen. (mpg.de)
Pulmonary hypertension1
- TGF-ß activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. (ucdenver.edu)
Spine3
- Three months postoperatively, the lumbar spine underwent high-resolution micro-computed tomography for analysis of bone formation, density, and bridging fusion. (ijssurgery.com)
- Locally delivered ascorbic acid and β-glycerophosphate in a murine model of posterior spinal fusion yielded statistically significant increases in new bone formation in the lumbar spine but statistically significant decreases in mineralized bone fraction. (ijssurgery.com)
- Bone morphogenetic protein (rhBMP) should not be routinely used in any type of anterior cervical spine fusion, such as with anterior cervical discectomy and fusion . (wikipedia.org)
Induces2
- Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms. (umassmed.edu)
- We report that bone morphogenetic protein-2 (BMP-2) induces an increase in Osterix expression, which is mediated through a homeodomain sequence located in the proximal region of the Osterix promoter. (ub.edu)
Superfamily1
- Development Citalopram Hydrobromide manufacture Differentiation Element 15 (GDF15) GDF15 is usually a divergent person in the BMP-subfamily from the TGF- superfamily. (cp-724714.com)
Inhibitors1
- This article is part of a Special Issue entitled: Inhibitors of Protein Kinases. (elsevier.com)
Noggin3
- The BMP-7-binding affinity of site-specific variants of Noggin is correlated with alterations in bone formation and apoptosis in chick limb development, showing that Noggin functions by sequestering its ligand in an inactive complex. (nature.com)
- Figure 5: Binding affinity of Noggin proteins for BMP-7. (nature.com)
- Zimmerman, L. B., De Jesus-Escobar, J. M. & Harland, R. M. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. (nature.com)
Recombinant proteins1
- CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (bio-techne.com)
Osteoblast1
- Thymoquinone accelerates osteoblast differentiation and activates bone morphogenetic protein-2 and ERK pathway. (imhr.de)
Spinal4
- Surgical treatment for primary spinal aneurysmal bone cysts: experience from Boston Children's Hospital. (childrenshospital.org)
- More than $3 billion is lost annually in direct and indirect costs due to failures to heal or form bone, such as the case with spinal fusion. (ijssurgery.com)
- There are many types of spinal fusion and each technique involves using bone grafting -either from the patient ( autograft ), donor ( allograft ), or artificial bone substitutes-to help the bones heal together. (wikipedia.org)
- HGGs represent 15 to 20 percent of brain and spinal tumors in children. (stjude.org)
Autologous3
- Treatment of a natural pig ONFH by autologous BMSCs indicated a beginning of bone healing as early as 2 weeks with a complete healing after 9 weeks. (biomedcentral.com)
- To avoid arthroplasty, many conservative procedures are used in the early pre-collapse stage of ONFH, including core decompression associated (or not) with autologous bone marrow (BM) grafting [ 3 , 4 ]. (biomedcentral.com)
- Autologous bone is the material of choice. (annals.edu.sg)
Grafts3
- Many ASD cases require multilevel fusion, requiring more bone grafts than typical single-level fusion. (e-neurospine.org)
- Objective-To evaluate scintigraphy, radiography, and histomorphometric analysis for assessing incorporation of intercalary bone grafts and to compare incorporation of cortical autografts and allografts by the recipient. (orthovetsupersite.com)
- PentOS OI™ Max is the newest member of the PentOS OI™ family of bone grafts for oral and maxillofacial surgery. (antibethera.com)
Liver2
- Dipsacus asperoides is a commonly used traditional Chinese medicine, which has the actions of nourishing liver and kidney, strengthening tendons and bones and preventing uterine bleeding [ 1 ]. (alliedacademies.org)
- The liver requires vitamin K in order to make blood clotting proteins, and as this article discusses, for the regulation of calcium deposition. (aor.us)
Surg2
- J Bone Joint Surg Am. 2010 Aug 4;92(9):1827-33. (childrenshospital.org)
- J Bone Joint Surg Am. 2012 94(21):1946-51. (kumc.edu)
Regulation5
- These studies suggest that BMP-15 plays a vital role in the normal regulation of folliculogenesis and ovulation in sheep. (wikipedia.org)
- Anti-Müllerian hormone regulation by the bone morphogenetic proteins in the sheep ovary: deciphering a direct regulatory pathway. (inra.fr)
- A family of BONE MORPHOGENETIC PROTEIN-related proteins that are primarily involved in regulation of CELL DIFFERENTIATION. (rush.edu)
- Rahman MS, Akhtar N, Jamil HM, et al.TGF-β/BMP sig-naling and other molecular events: regulation of osteoblasto-genesis and bone formation[J]. Bone Res, 2015, 3: 15005. (hxkqyxzz.net)
- 3 Both the bones and the arterial system have their own regulation mechanisms, therefore it is clear that there are other processes occurring to cause abnormal calcium deposition in the arteries in the case of diseased arteries. (aor.us)
Formation10
- A bone morphogenetic protein that is a potent inducer of BONE formation. (umassmed.edu)
- IMSEAR at SEARO: Content of bone morphogenetic protein-4 in human demineralized bone: relationship to donor age and ability to induce new bone formation. (who.int)
- Urist, M. R. Bone: formation by autoinduction. (nature.com)
- Additionally, studies have shown that cell spreading and the formation of lamellipodia and filopodia are stimulated by P-15. (tobig.eu)
- Experimental studies have shown cell activation and focal adhesion formation The experimental studies made use of different cell cultures and although P-15 promoted cell adhesion and activation, different pathways of integrin signalling were noted. (tobig.eu)
- 7 , 8 Therefore, the development of a newer, lower-cost, noninferior method for bone healing and formation with fewer complications is needed. (ijssurgery.com)
- this protein called morphogenetic protein-2 has an important function in influencing the formation of bone. (aor.us)
- Prescription drugs such as alendronate (Fossimax) and raloxifene (Evista) are able to increase calcium deposition in the bones, however they do not stop the formation of calcium plaques in the arteries. (aor.us)
- Microtubule\associated protein 1 light chain 3 beta\II (MAP1LC3B\II) is an autophagy marker and a lipidated form of MAP1LC3B\I. It is associated with autophagosomal membranes and is fundamental for the Isorhamnetin 3-O-beta-D-Glucoside formation of the autophagosome 23. (leafbioscience.com)
- It is a specific biochemical marker of bone turnover and bone formation involved in bone mineralization and calcium homeostasis [ 8 ]. (biomedcentral.com)
Factor3
- The data are compatible with bone morphogenetic protein 7 deficiency as a pathophysiologic factor in chronic renal failure, and they demonstrate its efficacy as a potential treatment of vascular calcification. (wustl.edu)
- Hoffmann B , Annis D, Mosher D. (2011) Reactivity of the N-terminal region of fibronectin protein to transglutaminase 2 and factor XIIIa. (wisc.edu)
- Right here, we show a 70-kDa vitelline layer protein, HrVC70, comprising 12 epidermal development factor-like repeats, has an integral role in personal/nonself reputation during ascidian fertilization. (arcillaresearch.com)
Efficacy1
- However, safety and efficacy of BMSCs to treat bone defect are the main preclinical data required for clinical application. (biomedcentral.com)
Inflammation2
- High doses of bone morphogenetic protein 2 induce structurally abnormal bone and inflammation in vivo. (atlasgeneticsoncology.org)
- ethanol extracts of Garcinia mangostana L. peel and propolis) had inhibitory effects on inflammation and alveolar bone loss in silk-ligature. (koreamed.org)
Kinase2
- Fam20C is an atypical kinase implicated in bio-mineralization and phosphate homeostasis disorders, and has recently been shown to account for the activity of an orphan enzyme ("genuine casein kinase", G-CK) previously characterized for its ability to phosphorylate casein and a plethora of secreted proteins at serine residues specified by the S-x-E/pS motif. (elsevier.com)
- Fanning S § , Xu W § , Beaurepaire C, Suhan J, Nantel A, Mitchell A * . Functional control of the Candida albicans cell wall by catalytic protein kinase A subunit Tpk1. (cmu.edu)
Follicle1
- BMP-15 prevents differentiation into preovulatory follicle by inhibiting FSH action in granulosa. (wikipedia.org)
Promotes4
- BMP-15 promotes the change of primordial to primary and secondary follicles which are surrounded by several granulosa cell layers but doesn't promote transition into preovulatory follicles. (wikipedia.org)
- Furthermore, P-15 promotes cell adhesion by providing a network of surface adhesion points for cell attachment. (tobig.eu)
- P-15 promotes cell attachment. (tobig.eu)
- P-15 promotes cell adhesion and spreading. (tobig.eu)