Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.
A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.
A subtype of bone morphogenetic protein receptors with high affinity for BONE MORPHOGENETIC PROTEINS. They can interact with and undergo PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II. They signal primarily through RECEPTOR-REGULATED SMAD PROTEINS.
A family of CELL SURFACE RECEPTORS that bind BONE MORPHOGENETIC PROTEINS. They are PROTEIN-SERINE-THREONINE KINASES that mediate SIGNAL TRANSDUCTION PATHWAYS through SMAD PROTEINS.
A bone morphogenetic protein that is a potent inducer of BONE formation. It plays additional roles in regulating CELL DIFFERENTIATION of non-osteoblastic cell types and epithelial-mesenchymal interactions.
A subtype of bone morphogenetic protein receptors with low affinity for BONE MORPHOGENETIC PROTEINS. They are constitutively active PROTEIN-SERINE-THREONINE KINASES that can interact with and phosphorylate TYPE I BONE MORPHOGENETIC PROTEIN RECEPTORS.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
A bone morphogenetic protein that may play a role in CARTILAGE formation. It is a potent regulator of the growth of CHONDROCYTES and the synthesis of cartilage matrix proteins. Evidence for its role in cartilage formation can be seen in MICE, where genetic mutations that cause loss of bone morphogenetic protein 5 function result in the formation of small malformed ears.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS. It regulates BONE MORPHOGENETIC PROTEIN signaling and plays an essential role in EMBRYONIC DEVELOPMENT.
A family of proteins that are involved in the translocation of signals from TGF-BETA RECEPTORS; BONE MORPHOGENETIC PROTEIN RECEPTORS; and other surface receptors to the CELL NUCLEUS. They were originally identified as a class of proteins that are related to the mothers against decapentaplegic protein, Drosophila and sma proteins from CAENORHABDITIS ELEGANS.
A bone morphogenetic protein that is found at high concentrations in a purified osteoinductive protein fraction from BONE. Bone morphogenetic protein 3 is referred to as osteogenin, however it may play a role in variety of developmental processes.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS. It regulates BONE MORPHOGENETIC PROTEIN signaling and is essential for PHYSIOLOGICAL ANGIOGENESIS.
A protein that plays a role in GRANULOSA CELLS where it regulates folliculogenesis. Mutations in the gene for bone morphogenetic protein 15 are linked to reproductive abnormalities such as PREMATURE OVARIAN FAILURE.
A bone morphogenetic protein family member that includes an active tolloid-like metalloproteinase domain. The metalloproteinase activity of bone morphogenetic protein 1 is specific for the removal of the C-propeptide of PROCOLLAGEN and may act as a regulator of EXTRACELLULAR MATRIX deposition. Alternative splicing of MRNA for bone morphogenetic protein 1 results in the production of several PROTEIN ISOFORMS.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
An inhibitory Smad protein that negatively regulates the SIGNAL TRANSDUCTION PATHWAYS from BONE MORPHOGENETIC PROTEIN RECEPTORS. Smad6 inhibits PHOSPHORYLATION of SMAD2 PROTEIN and SMAD3 PROTEIN.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by BONE MORPHOGENETIC PROTEIN RECEPTORS and regulates BONE MORPHOGENETIC PROTEIN signaling.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The process of bone formation. Histogenesis of bone including ossification.
A growth differentiation factor that plays a regulatory role as a paracrine factor for a diverse array of cell types during EMBRYONIC DEVELOPMENT and in the adult tissues. Growth differentiation factor 2 is also a potent regulator of CHONDROGENESIS and was previously referred to as bone morphogenetic protein 9.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Cell surface receptors that bind growth or trophic factors with high affinity, triggering intracellular responses which influence the growth, differentiation, or survival of cells.
A family of BONE MORPHOGENETIC PROTEIN-related proteins that are primarily involved in regulation of CELL DIFFERENTIATION.
A growth differentiation factor that plays a role in early CHONDROGENESIS and joint formation.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
A bone morphogenetic protein that plays an essential role in the regulation of ovarian folliculogenesis.
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
Bone loss due to osteoclastic activity.
One of the two types of ACTIVIN RECEPTORS or activin receptor-like kinases (ALK'S). There are several type I activin receptors. The major active ones are ALK-2 (ActR-IA) and ALK-4 (ActR-IB).
A growth differentiation factor that plays a role in the neural differentiation, specifically in the retinal development of the EYE.
Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
A signal transducing adaptor protein and tumor suppressor protein. It forms a complex with activated RECEPTOR-REGULATED SMAD PROTEINS. The complex then translocates to the CELL NUCLEUS and regulates GENETIC TRANSCRIPTION of target GENES.
Tumors or cancer located in bone tissue or specific BONES.
One of the two types of ACTIVIN RECEPTORS. They are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES. The major type II activin receptors are ActR-IIA and ActR-IIB.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Diseases of BONES.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
A broadly distributed protein that binds directly to ACTIVINS. It functions as an activin antagonist, inhibits FOLLICLE STIMULATING HORMONE secretion, regulates CELL DIFFERENTIATION, and plays an important role in embryogenesis. Follistatin is a single glycosylated polypeptide chain of approximately 37-kDa and is not a member of the inhibin family (INHIBINS). Follistatin also binds and neutralizes many members of the TRANSFORMING GROWTH FACTOR BETA family.
The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.
The middle germ layer of an embryo derived from three paired mesenchymal aggregates along the neural tube.
Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.
A negative regulator of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS that blocks activation of CYCLIN-DEPENDENT KINASE INHIBITOR P16 and is de-regulated in a variety of NEOPLASMS.
Transport proteins that carry specific substances in the blood or across cell membranes.
A family of smad proteins that undergo PHOSPHORYLATION by CELL SURFACE RECEPTORS in response to TRANSFORMING GROWTH FACTOR BETA; ACTIVIN; or BONE MORPHOGENETIC PROTEIN signaling.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
A family of metalloproteases that are related to the DROSOPHILA protein tolloid, which is a gene product necessary for dorsal-ventral patterning in early Drosophila embryogenesis. Many members of the group may play a significant role in intercellular signaling.
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
The grafting of bone from a donor site to a recipient site.
A homeodomain protein that interacts with TATA-BOX BINDING PROTEIN. It represses GENETIC TRANSCRIPTION of target GENES and plays a critical role in ODONTOGENESIS.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Proteins obtained from various species of Xenopus. Included here are proteins from the African clawed frog (XENOPUS LAEVIS). Many of these proteins have been the subject of scientific investigations in the area of MORPHOGENESIS and development.
The development of bony substance in normally soft structures.
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
The formation of cartilage. This process is directed by CHONDROCYTES which continually divide and lay down matrix during development. It is sometimes a precursor to OSTEOGENESIS.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
A disease characterized by bony deposits or the ossification of muscle tissue.
An inhibitory smad protein that associates with TRANSFORMING GROWTH FACTOR BETA RECEPTORS and BONE MORPHOGENETIC PROTEIN RECEPTORS. It negatively regulates SIGNAL TRANSDUCTION PATHWAYS by inhibiting PHOSPHORYLATION of RECEPTOR-REGULATED SMAD PROTEINS.
A family of intercellular signaling proteins that play and important role in regulating the development of many TISSUES and organs. Their name derives from the observation of a hedgehog-like appearance in DROSOPHILA embryos with genetic mutations that block their action.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.
Forms of hepcidin, a cationic amphipathic peptide synthesized in the liver as a prepropeptide which is first processed into prohepcidin and then into the biologically active hepcidin forms, including in human the 20-, 22-, and 25-amino acid residue peptide forms. Hepcidin acts as a homeostatic regulators of iron metabolism and also possesses antimicrobial activity.
Polymorphic cells that form cartilage.
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Established cell cultures that have the potential to propagate indefinitely.
The outer of the three germ layers of an embryo.
The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
A Wnt protein subtype that plays a role in cell-cell signaling during EMBRYONIC DEVELOPMENT and the morphogenesis of the developing NEURAL TUBE.
Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Proteins prepared by recombinant DNA technology.
Cell-surface proteins that bind transforming growth factor beta and trigger changes influencing the behavior of cells. Two types of transforming growth factor receptors have been recognized. They differ in affinity for different members of the transforming growth factor beta family and in cellular mechanisms of action.
Breaks in bones.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.
A Wnt protein subtype that plays a role in cell-cell signaling during EMBRYONIC DEVELOPMENT and the morphogenesis of the developing NEURAL TUBE. Defects in Wnt3 protein are associated with autosomal recessive tetra-AMELIA in humans.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. It regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
The physiological restoration of bone tissue and function after a fracture. It includes BONY CALLUS formation and normal replacement of bone tissue.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.
The two longitudinal ridges along the PRIMITIVE STREAK appearing near the end of GASTRULATION during development of nervous system (NEURULATION). The ridges are formed by folding of NEURAL PLATE. Between the ridges is a neural groove which deepens as the fold become elevated. When the folds meet at midline, the groove becomes a closed tube, the NEURAL TUBE.
The founding member of the nodal signaling ligand family of proteins. Nodal protein was originally discovered in the region of the mouse embryo primitive streak referred to as HENSEN'S NODE. It is expressed asymmetrically on the left side in chordates and plays a critical role in the genesis of left-right asymmetry during vertebrate development.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Signal molecules that are involved in the control of cell growth and differentiation.
Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The developmental stage that follows BLASTULA or BLASTOCYST. It is characterized by the morphogenetic cell movements including invagination, ingression, and involution. Gastrulation begins with the formation of the PRIMITIVE STREAK, and ends with the formation of three GERM LAYERS, the body plan of the mature organism.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
The complex processes of initiating CELL DIFFERENTIATION in the embryo. The precise regulation by cell interactions leads to diversity of cell types and specific pattern of organization (EMBRYOGENESIS).
An aquatic genus of the family, Pipidae, occurring in Africa and distinguished by having black horny claws on three inner hind toes.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Elements of limited time intervals, contributing to particular results or situations.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Congenital structural deformities of the upper and lower extremities collectively or unspecified.
Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectively
Supporting cells for the developing female gamete in the OVARY. They are derived from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the OOCYTE in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the OVUM in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors (RECEPTORS, LH).
Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
Formation of differentiated cells and complicated tissue organization to provide specialized functions.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
The farthest or outermost projections of the body, such as the HAND and FOOT.
They are glycopeptides and subunits in INHIBINS and ACTIVINS. Inhibins and activins belong to the transforming growth factor beta superfamily.
A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
The inner of the three germ layers of an embryo.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
The inner and longer bone of the FOREARM.
Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.
Cellular signaling in which a factor secreted by a cell affects other cells in the local environment. This term is often used to denote the action of INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS on surrounding cells.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Congenital anomaly of abnormally short fingers or toes.
Inhibitor of differentiation proteins are negative regulators of BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS. They inhibit CELL DIFFERENTIATION and induce CELL PROLIFERATION by modulating different CELL CYCLE regulators.
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
A tube-like invagination of the EPIDERMIS from which the hair shaft develops and into which SEBACEOUS GLANDS open. The hair follicle is lined by a cellular inner and outer root sheath of epidermal origin and is invested with a fibrous sheath derived from the dermis. (Stedman, 26th ed) Follicles of very long hairs extend into the subcutaneous layer of tissue under the SKIN.
A growth differentiation factor that is closely-related in structure to BONE MORPHOGENETIC PROTEIN 3. Growth differentiation factor 10 is found at high levels in BONE, however it plays an additional roles in regulating EMBRYONIC DEVELOPMENT.
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Morphological and physiological development of EMBRYOS.
A cell line derived from cultured tumor cells.
Breaks in CARTILAGE.
Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
A SOXE transcription factor that plays a critical role in regulating CHONDROGENESIS; OSTEOGENESIS; and male sex determination. Loss of function of the SOX9 transcription factor due to genetic mutations is a cause of CAMPOMELIC DYSPLASIA.
The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
The process of TOOTH formation. It is divided into several stages including: the dental lamina stage, the bud stage, the cap stage, and the bell stage. Odontogenesis includes the production of tooth enamel (AMELOGENESIS), dentin (DENTINOGENESIS), and dental cementum (CEMENTOGENESIS).
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
Broadly distributed glycoproteins that are homologous to the activin-binding protein, FOLLISTATIN. These follistatin-related proteins are encoded by a number of genes.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
A fibroblast growth factor that preferentially activates FIBROBLAST GROWTH FACTOR RECEPTOR 4. It was initially identified as an androgen-induced growth factor and plays a role in regulating growth of human BREAST NEOPLASMS and PROSTATIC NEOPLASMS.
Culture media containing biologically active components obtained from previously cultured cells or tissues that have released into the media substances affecting certain cell functions (e.g., growth, lysis).
A union between adjacent bones or parts of a single bone formed by osseous material, such as ossified connecting cartilage or fibrous tissue. (Dorland, 27th ed)
Pathologic deposition of calcium salts in tissues.
A TGF-beta subtype that plays role in regulating epithelial-mesenchymal interaction during embryonic development. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta3 and TGF-beta3 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).
A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
An OOCYTE-containing structure in the cortex of the OVARY. The oocyte is enclosed by a layer of GRANULOSA CELLS providing a nourishing microenvironment (FOLLICULAR FLUID). The number and size of follicles vary depending on the age and reproductive state of the female. The growing follicles are divided into five stages: primary, secondary, tertiary, Graafian, and atretic. Follicular growth and steroidogenesis depend on the presence of GONADOTROPINS.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
The granulosa cells of the cumulus oophorus which surround the OVUM in the GRAAFIAN FOLLICLE. At OVULATION they are extruded with OVUM.
A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.
Mice bearing mutant genes which are phenotypically expressed in the animals.
An early embryonic developmental process of CHORDATES that is characterized by morphogenic movements of ECTODERM resulting in the formation of the NEURAL PLATE; the NEURAL CREST; and the NEURAL TUBE. Improper closure of the NEURAL GROOVE results in congenital NEURAL TUBE DEFECTS.
Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.
The region in the dorsal ECTODERM of a chordate embryo that gives rise to the future CENTRAL NERVOUS SYSTEM. Tissue in the neural plate is called the neuroectoderm, often used as a synonym of neural plate.

The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal septation and positioning of the heart. (1/124)

Mammalian Tolloid-like 1 (mTLL-1) is an astacin-like metalloprotease, highly similar in domain structure to the morphogenetically important proteases bone morphogenetic protein-1 (BMP-1) and Drosophila Tolloid. To investigate possible roles for mTLL-1 in mammalian development, we have used gene targeting in ES cells to produce mice with a disrupted allele for the corresponding gene, Tll1. Homozygous mutants were embryonic lethal, with death at mid-gestation from cardiac failure and a unique constellation of developmental defects that were apparently confined solely to the heart. Constant features were incomplete formation of the muscular interventricular septum and an abnormal and novel positioning of the heart and aorta. Consistent with roles in cardiac development, Tll1 expression was specific to precardiac tissue and endocardium in 7.5 and 8.5 days p.c. embryos, respectively. Tll1 expression was also high in the developing interventricular septum, where expression of the BMP-1 gene, Bmp1, was not observed. Cardiac structures that were not affected in Tll1-/- embryos either showed no Tll1 expression (atrio-ventricular cushions) or showed overlapping expression of Tll1 and Bmp1 (aortico-pulmonary septum), suggesting that products of the Bmp1 gene may be capable of functionally substituting for mTLL-1 at sites in which they are co-expressed. Together, the various data show that mTLL-1 plays multiple roles in formation of the mammalian heart and is essential for formation of the interventricular septum.  (+info)

Bone morphogenetic protein 1 regulates dorsal-ventral patterning in early Xenopus embryos by degrading chordin, a BMP4 antagonist. (2/124)

Bone morphogenetic protein 1 (BMP1) is a metalloprotease that ventralises dorsal mesoderm when overexpressed in early Xenopus embryos. Here we show that Xenopus BMP1 blocks the dorsalising activity of chordin, but not noggin or DeltaxBMPR, when coexpressed in the ventral marginal zone and degrades chordin protein in vitro. We also show that a dominant-negative mutation for XBMP1 (dnBMP1) dorsalises ventral mesoderm in vivo, and blocks degradation of chordin by both XBMP1 and Xolloid, a closely related Xenopus metalloprotease, in vitro. dnBMP1 does not dorsalise ventral mesoderm in UV-irradiated embryos, demonstrating that this activity is dependent upon a functional organiser--the natural source of chordin in Xenopus gastrulae. Our results suggest that XBMP1 may regulate the availability of chordin during vertebrate embryogenesis.  (+info)

Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis. (3/124)

Vertebrate bone morphogenetic protein 1 (BMP-1) and Drosophila Tolloid (TLD) are prototypes of a family of metalloproteases with important roles in various developmental events. BMP-1 affects morphogenesis, at least partly, via biosynthetic processing of fibrillar collagens, while TLD affects dorsal-ventral patterning by releasing TGFbeta-like ligands from latent complexes with the secreted protein Short Gastrulation (SOG). Here, in a screen for additional mammalian members of this family of developmental proteases, we identify novel family member mammalian Tolloid-like 2 (mTLL-2) and compare enzymatic activities and expression domains of all four known mammalian BMP-1/TLD-like proteases [BMP-1, mammalian Tolloid (mTLD), mammalian Tolloid-like 1 (mTLL-1), and mTLL-2]. Despite high sequence similarities, distinct differences are shown in ability to process fibrillar collagen precursors and to cleave Chordin, the vertebrate orthologue of SOG. As previously demonstrated for BMP-1 and mTLD, mTLL-1 is shown to specifically process procollagen C-propeptides at the physiologically relevant site, while mTLL-2 is shown to lack this activity. BMP-1 and mTLL-1 are shown to cleave Chordin, at sites similar to procollagen C-propeptide cleavage sites, and to counteract dorsalizing effects of Chordin upon overexpression in Xenopus embryos. Proteases mTLD and mTLL-2 do not cleave Chordin. Differences in enzymatic activities and expression domains of the four proteases suggest BMP-1 as the major Chordin antagonist in early mammalian embryogenesis and in pre- and postnatal skeletogenesis.  (+info)

Expression of chick BMP-1/Tolloid during patterning of the neural tube and somites. (4/124)

The expression pattern described here is that of the chick BMP-1/Tolloid family of secreted metalloproteinases during early stages of development. BMP-1/Tolloid transcripts are expressed in the blastoderm, at gastrulation stages and as the neural plate forms and neural tube folds, BMP-1/Tolloid is found at the neural plate/ectodermal transition. Expression is maintained in the premigratory neural crest, and transiently in the migrating cephalic neural crest cells. BMP-1/Tolloid is also expressed in the caudal, but not in the anterior notochord, and in the ventral neural tube at the time of dorso-ventral patterning. Further sites of BMP-1/Tolloid expression are the lateral plate mesoderm and the dermotome and the myotome of the somites.  (+info)

Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain. (5/124)

Epithelial cells maintained in culture medium containing low calcium proteolytically process laminin 5 (alpha3beta3gamma2) within the alpha3 and gamma2 chains (). Experiments were designed to identify the enzyme(s) responsible for the laminin 5 processing and the sites of proteolytic cleavage. To characterize the nature of laminin 5 processing, we determined the N-terminal amino acid sequences of the proteolytic fragments produced by the processing events. The results indicate that the first alpha3 chain cleavage (200-l65 kDa alpha3) occurs within subdomain G4 of the G domain. The second cleavage (l65-l45 kDa alpha3) occurs within the lIla domain, 11 residues N-terminal to the start of domain II. The gamma chain is cleaved within the second epidermal growth factor-like repeat of domain Ill. The sequence cleaved within the gamma2 chain matches the consensus sequence for the cleavage of type I, II, and III procollagens by bone morphogenetic protein-1 (BMP-1), also known as type I procollagen C-proteinase (). Recombinant BMP-1 cleaves gamma2 in vitro, both within intact laminin 5 and at the predicted site of a recombinant gamma2 short arm. alpha3 is also cleaved by BMP-1 in vitro, but the cleavage site is yet to be determined. These results show the laminin alpha3 and gamma2 chains to be substrates for BMP-1 in vitro. We speculate that gamma2 cleavage is required for formation of the laminin 5-6 complex and that this complex is directly involved in assembly of the interhemidesmosomal basement membrane. This further suggests that BMP-1 activity facilitates basement membrane assembly, but not hemidesmosome assembly, in the laminin 5-rich dermal-epidermal junction basement membrane in vivo.  (+info)

Profiling of genes which are differentially expressed in mouse liver in response to adenoviral vectors and delivered genes. (6/124)

The effects of transgene delivery by adenoviral vectors were studied by probing a 588 gene, mouse cDNA array with mRNA derived from infected liver. The liver tissues were obtained from naive mice and mice infected with replication-deficient adenovirus, adenovirus expressing transforming growth factor beta1 (TGFbeta1), and adenovirus expressing connective tissue growth factor (CTGF). Expression of 98 genes was detected in the array analysis. The increased expression of the transcripts for Stat1, gamma interferon-induced monokine (MIG) and interferon regulatory factor 1 (IRF1) clearly demonstrated the immune response induced by infection with a first generation, replication-incompetent adenovirus. In vivo expression of TGFbeta1 led to a down-regulation of genes involved in the immune response. The increased expression of u-PAR1, laminin receptor and BMP-1 confirms the importance of CTGF and TGFbeta1 in angiogenesis, and tissue repair. Expression of the serine protease inhibitors, Spi 2.4 and Spi 2, is also increased in response to AdTGFbeta1 and AdCTGF.  (+info)

Is chordin a long-range- or short-range-acting factor? Roles for BMP1-related metalloproteases in chordin and BMP4 autofeedback loop regulation. (7/124)

Diffusible morphogen models have been used widely to explain regional specification of tissues and body axes during animal development. The three-signal model for patterning the dorsal-ventral axis of the amphibian embryo proposes, in part, that a factor(s) secreted from Spemann's organizer is responsible for converting lateral marginal zone into more dorsal cell fates. We examine the possibility that chordin, a secreted inhibitor of bone morphogenetic protein (BMP) signaling and candidate "dorsalizing signal," is a long-range-acting factor. We show that chordin can, when overexpressed, act directly over distances of at least 450 microm in the early Xenopus embryo to create a gradient of BMP signaling. However, since lower levels of chordin can still induce secondary axes and these amounts of chordin act only locally to inhibit a BMP target gene, we suggest that chordin likely acts as a short-range signal in vivo. Furthermore, BMP1, a secreted metalloprotease that cleaves chordin protein in vitro, inhibits chordin's axis-inducing effects, suggesting that BMP1 functions to negatively regulate chordin's action in vivo. A dominant-negative mutant BMP1 blocks the in vitro cleavage of chordin protein by wild-type BMP1 and induces secondary axes when injected ventrally. We argue that BMP1 and Xolloid are probably functionally redundant metalloproteases and may have two roles in the early Xenopus embryo. One role may be to inhibit the action of low-level chordin protein expressed throughout the entire embryo and a possible second role may be to inhibit activation of a juxtacrine cell relay, thereby confining chordin's action to the organizer region preventing chordin from functioning as a long-range-acting factor.  (+info)

Bone morphogenetic protein-1 processes probiglycan. (8/124)

Bone morphogenetic protein-1 (BMP-1) is a metalloprotease that plays important roles in regulating the deposition of fibrous extracellular matrix in vertebrates, including provision of the procollagen C-proteinase activity that processes the major fibrillar collagens I-III. Biglycan, a small leucine-rich proteoglycan, is a nonfibrillar extracellular matrix component with functions that include the positive regulation of bone formation. Biglycan is synthesized as a precursor with an NH(2)-terminal propeptide that is cleaved to yield the mature form found in vertebrate tissues. Here, we show that BMP-1 cleaves probiglycan at a single site, removing the propeptide and producing a biglycan molecule with an NH(2) terminus identical to that of the mature form found in tissues. BMP-1-related proteases mammalian Tolloid and mammalian Tolloid-like 1 (mTLL-1) are shown to have low but detectable levels of probiglycan-cleaving activity. Comparison shows that wild type mouse embryo fibroblasts (MEFs) produce only fully processed biglycan, whereas MEFs derived from embryos homozygous null for the Bmp1 gene, which encodes both BMP-1 and mammalian Tolloid, produce predominantly unprocessed probiglycan, and MEFs homozygous null for both the Bmp1 gene and the mTLL-1 gene Tll1 produce only unprocessed probiglycan. Thus, all detectable probiglycan-processing activity in MEFs is accounted for by the products of these two genes.  (+info)

Expression of procollagen C-proteinase enhancer in cultured rat heart fibroblasts: evidence for co-regulation with type I collagen.: Procollagen processing by p
Shop Transducin-like enhancer protein ELISA Kit, Recombinant Protein and Transducin-like enhancer protein Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
TY - JOUR. T1 - MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways. AU - Zhang, Lisheng. AU - Yang, Lixin. AU - Liu, Xiyong. AU - Chen, Wei. AU - Chang, Lufen. AU - Chen, Linling. AU - Loera, Sofia. AU - Chu, Peiguo. AU - Huang, Wei Chien. AU - Liu, Yun Ru. AU - Yen, Yun. PY - 2013/5/1. Y1 - 2013/5/1. N2 - Growing evidence indicates that deregulation of microRNAs (miRNAs) contributes to tumorigenesis. Dysregulation of miR-657 has been observed in several types of cancers, but its biological function is still largely unknown. Our results showed that miR-657 expression can be induced by hepatitis viral proteins and is significantly increased in hepatocellular carcinoma (HCC) tissues. Moreover, introduction of miR-657 dramatically increases proliferation and colony formation of HCC cells in vitro and induces tumor development in immunodeficient mice. Further studies showed that miR-657 directly ...
Protein BM-1 (bahasa Inggris: procollagen C-peptidase, bone morphogenetic protein 1, mammalian tolloid, mTLD, procollagen C-proteinase, procollagen C-terminal proteinase; carboxyprocollagen peptidase; procollagen C-terminal peptidase; procollagen C-proteinase; procollagen C-terminal proteinase; procollagen carboxypeptidase; procollagen carboxy-terminal proteinase; procollagen peptidase, BMP-1, EC 3.4.24.19) merupakan enzim metaloprotease yang mengiris terminus-C pada posisi Ala-Asp pada prokolagen tipe I dan II, dan pada posisi arg-Asp pada prokolagen tipe III,[1] dalam proses aktivasi prekursor protein yang berperan dalam pembentukan jaringan matriks ekstraselular, termasuk aktivasi protelitik terhadap zimogen dari oksidase lisil.[2] Marimastat merupakan senyawa penghambat aktivitas BMP-1.[3] Aktivitas BMP-1 akan meningkat oleh kalsium, fibronektin,[2] sFRP,[4] dan sejenis glikoprotein dengan kofaktor berupa Zn,[5] Protein sFR merupakan target terapi fibrosis jantung.[4] ...
View mouse Pcolce Chr5:137605103-137613784 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG (By similarity).
PLN00042 (PSSM ID: 177676): Conserved Protein Domain Family PLN00042, photosystem II oxygen-evolving enhancer protein 2; Provisional
1bw5: The solution structure of the homeodomain of the rat insulin-gene enhancer protein isl-1. Comparison with other homeodomains.
Clone REA981 recognizes the mouse and rat CD49b antigen, a transmembrane glycoprotein also known as integrin alpha-2 (Itga2). CD49 is found on activated lymphocytes, epithelial cells, and platelets. In association with CD29 (integrin β-1), a VLA-2 complex is formed, which functions as a receptor for collagen and collagen C-propeptides, laminin, and E-cadherin. Additional information: Clone REA981 displays negligible binding to Fc receptors. - USA
Gentaur molecular products has all kinds of products like :search , Reliatech \ Anti_Mouse, mab PCPE_1 Source Rat \ 103-M450 for more molecular products just contact us
Several of the above proteins consist of a catalytic domain together with several CUB domains interspersed by calcium-binding EGF domains. Some CUB domains appear to be involved in oligomerisation and/or recognition of substrates and binding partners. For example, in the complement proteases, the CUB domains mediate dimerisation and binding to collagen-like regions of target proteins (e.g. C1q for C1r/C1s). The structure of CUB domains consists of a beta-sandwich with a jelly-roll fold. Almost all CUB domains contain four conserved cysteines that probably form two disulphide bridges (C1-C2, C3-C4). The CUB1 domains of C1s and Map19 have calcium-binding sites [(PUBMED:17446170)].. ...
Several of the above proteins consist of a catalytic domain together with several CUB domains interspersed by calcium-binding EGF domains. Some CUB domains appear to be involved in oligomerisation and/or recognition of substrates and binding partners. For example, in the complement proteases, the CUB domains mediate dimerisation and binding to collagen-like regions of target proteins (e.g. C1q for C1r/C1s). The structure of CUB domains consists of a beta-sandwich with a jelly-roll fold. Almost all CUB domains contain four conserved cysteines that probably form two disulphide bridges (C1-C2, C3-C4). The CUB1 domains of C1s and Map19 have calcium-binding sites [(PUBMED:17446170)].. ...
Presenilin enhancer protein 2 (PEN2) is a 101-amino acid protein that traverses the membrane twice and it is the regulatory component of the multimeric gamma-secretase complex which also consists of presenilin, APH-1 and Nicastrin. The gamma-secretase complex catalyzes the cleavage of a number of...
SWISS-MODEL Repository entry for P83504 (PSBO_BRACM), Oxygen-evolving enhancer protein 1, chloroplastic. Brassica campestris (Field mustard)
Выставка осенних букетов, композиций, экибан ко Дню учителя С первых дней октября фойе нашей школы наполнилось ароматами осени - это школьники в честь учителей устроили выставку осенних букетов, композиций, экибан, сделанных своими руками...
ADAMTS-2 is an extracellular metalloproteinase responsible for cleaving the N-propeptides of procollagens I-III; an activity necessary for the formation of collagenous ECM (extracellular matrix). The four TIMPs (tissue inhibitors of metalloproteinases) regulate the activities of matrix metalloproteinases, which are involved in degrading ECM components. Here we delineate the abilities of the TIMPs to affect biosynthetic processing of procollagens. TIMP-1, -2 and -4 show no inhibitory activity towards ADAMTS-2, in addition none of the TIMPs showed inhibitory activity towards bone morphogenetic protein 1, which is responsible for cleaving procollagen C-propeptides. In contrast, TIMP-3 is demonstrated to inhibit ADAMTS-2 in vitro with apparent Ki values of 160 and 602 nM, in the presence of heparin or without respectively; and TIMP-3 is shown to inhibit procollagen processing by cells.
Risk in products will pass at the time of delivery to the customer. The customer is responsible for unloading and transporting large and/or heavy items from delivery vans. In view of the hazards of certain chemicals and apparatus the customer must ensure that the products purchased are in a safe condition and that a safe system of work is in place taking into account all available information. None of the products sold are intended for human consumption unless otherwise clearly stated. In view of the wide range of uses of chemicals and apparatus, the customer will be solely responsible for determining the suitability and specification of products, services, information and advice for its purposes. VWR has the right, without notice, to supply product of different specifications, sources, and pack size to that published or ordered. The customer is required to ensure that that the use of any products supplied by VWR do not infringe third party intellectual property rights. In view of the above, ...
Complete information for TLL1 gene (Protein Coding), Tolloid Like 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
books.google.comhttps://books.google.com/books/about/Research_in_African_literatures.html?id=QDYzAAAAIAAJ&utm_source=gb-gplus-shareResearch in African literatures ...
291459338 - EP 1254270 A1 2002-11-06 - METHODS AND MATERIALS RELATING TO CUB DOMAIN POLYPEPTIDES AND POLYNUCLEOTIDES - [origin: WO0157267A1] The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted CUB domain polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from testis (Hyseq clone identification numbers 2924342 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel humain secreted CUB domain polypeptides, and antibodies specific for such polypeptides.[origin: WO0157267A1] The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted CUB domain polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from testis (Hyseq clone identification numbers 2924342 (SEQ
MAA573Mi21, P3NP; N-Propeptide Of Type III Procollagen; Procollagen III Amino Terminal Propeptide | Products for research use only!
Thanks for Bearbound for another great set of shots. This cub is uber sexy anyway, but to have him duct tape gagged and in a strict hogtie...so fucking hot ...
Toll-like receptor 7 (TLR7) triggers antiviral immune responses by recognizing viral single-stranded RNA in endosomes, but the biosynthetic pathway of human TLR7 (hTLR7) remains unclear. Here, we show that hTLR7 is proteolytically processed and that the C-terminal fragment selectively accumulates in endocytic compartments. hTLR7 processing occurred at neutral pH and was dependent on furin-like proprotein convertases (PCs). Furthermore, TLR7 processing was required for its functional response to TLR7 agonists such as R837 or influenza virus. Notably, proinflammatory and differentiation stimuli increased the expression of furin-like PCs in immune cells, suggesting a positive feedback mechanism for TLR7 processing during infection. Because self-RNA can under certain conditions activate TLR7 and trigger autoimmunity, our results identify furin-like PCs as a possible target to attenuate TLR7-dependent autoimmunity and other immune pathologies.
The South Bend Cubs are looking for enthusiastic, hardworking and customer service oriented people who want to be a part of our organization.
Planarians (flatworms) can regenerate from irregularly shaped fragments. During regeneration, new tissue forms at the wound and existing tissues are remodelled to make a complete, symmetrical animal. How is this amazing feat achieved? On p. 4043, Alejandro Sánchez Alvarados group report that BMP signalling regulates several aspects of regeneration in the planarian Schmidtea mediterranea. The researchers use RNAi knockdown to investigate the role of smedolloid-1 (a BMP1/Tolloid-like gene), smedsmad4-1 (a SMAD4-like gene) and smedbmp4-1 (a BMP2/4/DPP-like gene) in regeneration. These experiments show that BMP signalling is involved in the formation and dorsal-ventral (DV) patterning of new tissues at the reset midline of a regenerating fragment. Additional knockdown experiments indicate that BMP signalling also maintains the DV pattern in undamaged adult tissue. These and other results lead the researchers to propose that BMP signalling regulates the dorsal midline of planarians and that the ...
Laminin-5 and its cell surface receptor a6b4 integrin are required for development of squamous cell carcinomas. Lack of either of these molecules results in a lack of tumor growth, whereas overexpression of these molecules correlates with increasing tumor invasiveness and a worsening patient prognosis. We have identified that laminin-5 undergoes proteolytic processing of two of its three chains, via mammalian Tolloid, a metalloprotease of the astacin family. Processing of laminin-5 promotes tumor invasion. We are currently studying the mechanisms whereby these processing events influence tumor cell invasion, migration and metastasis. Type VII collagen appears to play a key role in tumor invasion, and appears to operate through association with laminin-5. We are currently studying the mechanism of this association and its role in tumorigenesis. The laminin-5 receptor a6b4 integrin interacts with laminin-5 at one end and with intracellular protein complexes at the other end, through which it ...
The investigators aim to compare the levels of bone morphogenetic protein-4 and -7 (BMP-4 and 7) in blood, follicular fluid and ovarian organ culture s
Description: CDCP1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 646 amino acids (30-667a.a.) and having a molecular mass of 72.8kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa). CDCP1 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques ...
Carragee and colleagues recently published an analysis of publicly available raw data from the Medtronic sponsored AMPLIFY study (a randomized controlled trial
As part of a continuing investigation into a bone morphogenetic protein-2 product marketed as Infuse, the |em|Milwaukee Journal Sentinel/MedPage Today|/em| describe a first-hand account of early signs
The Chicago Cubs will need to rely on the starting rotation as the anchor of the club in order to have any success in 2014.
Clone REAL133 is an antibody fragment derived from the full CD49b antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.Clone REAL133 recognizes the mouse CD49b antigen, a single-pass type I membrane protein also known as integrin alpha-2 (ITGA2). CD49b together with CD29 (ITGB1) forms the adhesion molecule very late antigen-2 (VLA-2), which binds mainly to collagens I, II, and XI. VLA-2 is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation, and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides, and E-cadherin. Mice homozygous for a null mutation in the CD49b gene die very early in embryogenesis. CD49b is expressed on the vast majority of mouse natural killer (NK) cells and on a subset of NKT cells. It is not as mouse
Fingerprint Dive into the research topics of Molecular basis of bone morphogenetic protein-15 signaling in granulosa cells. Together they form a unique fingerprint. ...
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Working near the Sikhote-Alin Zapovednik, the researchers located the den by tracking a radio-collared 3-year-old tigress named Galia. Of course, finding the cubs required some caution, particularly in making sure Mom was not home. The researchers waited until Galias radio signal indicated that she had left the den site before searching for the cubs, which they found in a collection of rocks on the slope of a hill. The cubs, who weighed from 6.5 to nine pounds, remained calm as the researchers handled and measured them. After collecting hair and blood samples for genetic and disease analysis, Goodrich and his team fitted them with radio collars and returned them to their den ...
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Originally Written for 10/5/08 Well, the week started off good - I mean really good. It was the first time in 102 years that both the Chicago Cubs and White Sox were playing in the post season at the same time. The Cubs finished the year with the best record in the national league and…
PHENOTYPE: Homozygous null mice were born at expected Mendelian ratio and healthy, fertile, apparently normal with normal retinal laminar structure. [provided by MGI curators ...
TY - JOUR. T1 - Bone morphogenetic protein-6 reduces ischemia-induced brain damage in rats. AU - Wang, Yun. AU - Chang, Chen Fu. AU - Morales, Marisela. AU - Chou, Jenny. AU - Chen, Hui Ling. AU - Chiang, Yung Hsiao. AU - Lin, Shinn Zong. AU - Cadet, Jean Lud. AU - Deng, Xiaolin. AU - Wang, Jia Yi. AU - Chen, Su Yu. AU - Kaplan, Paul L.. AU - Hoffer, Barry J.. PY - 2001. Y1 - 2001. N2 - Background and Purpose - Bone morphogenetic protein-6 (BMP6) and its receptors are expressed in adult and fetal brain. Receptors for BMP6 are upregulated in adult brain after injury, leading to the suggestion that BMP6 is involved in the physiological response to neuronal injury. The purpose of this study was to determine whether there was a neuroprotective effect of BMP6 in vivo and in vitro. Methods - Lactate dehydrogenase and microtubule-associated protein-2 (MAP-2) activities were used to determine the protective effect of BMP6 against H2O2 in primary cortical cultures. The neuroprotective effects of BMP6 ...
3 Liger Cubs were Born at Taiwan zoo in 2010. One of the liger cub died immediately at the time of the birth while 2 of the Survived in Taiwan. It is illegal to Cross-breed Lion and tiger to produce liger in Taiwan. Therefore, the Taiwanese Zoo owner who bred lion and tiger together was fined a penalty of around 15000 US Dollars. Recent Reports suggest that another liger cub has also died.
Every member of the Daytona Cubs probably has dreamt of teaming with a future Hall of Famer like Chicago Cubs second baseman Ryne Sandberg. Few probably figured on it happening so soon.Sandberg, a
A highly conserved TGF-β signaling pathway is involved in the establishment of the dorsoventral axis of the vertebrate embryo. Specifically, Bone Morphogenetic Proteins (Bmps) pattern ventral tissues of the embryo while inhibitors of Bmps, such as Chordin, Noggin and Follistatin, are implicated in dorsal mesodermal and neural development. We investigated the role of Tolloid, a metalloprotease that can cleave Chordin and increase Bmp activity, in patterning the dorsoventral axis of the zebrafish embryo. Injection of tolloid mRNA into six dorsalized mutants rescued only one of these mutants, mini fin. Through chromosomal mapping, linkage and cDNA sequence analysis of several mini fin alleles, we demonstrate that mini fin encodes the tolloid gene. Characterization of the mini fin mutant phenotype reveals that Mini fin/Tolloid activity is required for patterning ventral tissues of the tail: the ventral fin, and the ventroposterior somites and vasculature. Gene expression studies show that mfn ...
Fingerprint Dive into the research topics of Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis. Together they form a unique fingerprint. ...
To date, KB remains the only available tool for the evaluation of renal fibrosis. It requires preliminary tests and hospitalization and carries potential risks, including hematoma and hematuria. Moreover, its relevance may be limited because of the relatively small size of renal parenchyma assessed. The analysis of a limited area of the renal parenchyma does not necessarily reflect the ongoing fibrotic process occurring in other parts of the kidney. Thus, an alternative to KB for the assessment of renal fibrosis is required. Such noninvasive tests are already widely used as an alternative to biopsy for the evaluation of fibrosis in a major organ; namely, the liver. For instance, the fibro-test, a simple tool relying on easily available blood tests, is widely used as a first-line procedure for the staging of liver fibrosis (15,16).. We undertook a prospective study to assess the correlation of UPIIINP/Cr with patients characteristics and renal fibrosis and the relevance of UPIIIN/Cr as a ...
C3H10T1/2 cells are an established mesenchymal stem cell line which can differentiate into muscle, fat and cartilage cells when treated with azacytidine. Bone morphogenetic protein-2 (BMP-2) caused a dose dependent differentiation of these cells into fat, cartilage and bone cells-low concentrations …
Kovács, Tibor and Billes, Viktor and Komlós, Marcell and Hotzi, Bernadette and Manzéger, Anna and Tarnóci, Anna and Papp, Diána and Szikszai, Fanni and Szinyákovics, Janka and Ákos Rácz, Ákos and Noszál, Béla and Veszelka, Szilvia and Walter, Fruzsina R. and Deli, Mária A. and Hackler Jr., László and Alföldi, Róbert and Huzian, Orsolya and Puskás, László G. and Liliom, Hanna and Tárnok, Krisztián and Schlett, Katalin and Borsy, Adrienn and Welker, Ervin and Kovács, Attila L. and Pádár, Zsolt and Erdős, Attila and Légrádi, Ádám and Bjelik, Annamária and Gulya, Károly and Gulyás, Balázs and Vellai, Tibor (2017) The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms. SCIENTIFIC REPORTS. pp. 1-17. ISSN 2045-2322 Kovács, Tibor and Máthé, Domokos and Fülöp, András and Jemnitz, Katalin and Bátai-Konczos, Attila (2017) Functional shift with maintained regenerative potential following portal vein ligation. ...
Purified BMP-2 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
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Vitters is done with the Cubs. I have been one of his biggest supporters but as John pointed out he has been surpassed by FAR too many players. He needs a change of scenery and while I dont think he will be an allstar I could imagine him topping out as a starting OF or a 4-5 outfielder. I think he is frustrated that he is still at Iowa. Put him on another AAA team he might thrive and get pulled up.. His biggest problem is that he is a hacker. He never learned to take a walk (5% over 8 seasons). I really wonder if he would have done better under better coaching or if he is what he is.. Too bad everyone knows that he is done with the Cubs or else if I were an opposing GM I might be tempted to make an offer of a flyer on an A-Ball player (not a Top-30 guy) to give Vitters a shot.. At the same time I dont think Johns original comparison was fair. Comparing Vitters to Castro and Rizzo would be like calling all the Angels prospects over age 23 disappointing because at the same age or younger ...
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PITTSBURGH (AP) - Javier Baez hit a three-run home run and Kyle Hendricks pitched one-run ball over six innings Wednesday night to lead the Chicago Cubs to an…
What might be the most telling stat of the NLDS? James Loney drove in six runs for the Dodgers, or as many as the Cubs scored all series.
2000). "Bone morphogenetic protein-1 processes probiglycan". J. Biol. Chem. 275 (39): 30504-11. doi:10.1074/jbc.M004846200. ... 2001). "Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct ... with high sequence similarity to mammalian tolloid/bone morphogenetic protein-1". Genomics. 34 (2): 157-65. doi:10.1006/geno. ... Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene. This gene encodes an astacin-like zinc- ...
In a study in 1996, Greenspan's lab showed that Bone Morphogenetic Protein 1 (BMP-1) is a protease responsible for the ... Kessler, E., Takahara, K., Biniaminov, L., Brusel, M., & Greenspan, D. S. (1996). Bone morphogenetic protein-1: the type I ... ". "BMP1 controls TGFβ1 activation via cleavage of latent TGFβ-binding protein". "The bone morphogenetic protein 1/Tolloid-like ... "Bone Morphogenetic Protein-1: The Type I Procollagen C-Proteinas". "Erratum: Homologues of Twisted gastrulation are ...
... a disease characterized by the formation of heterotopic bone throughout the body. It is a bone morphogenetic protein receptor, ... This protein is important in the bone morphogenic protein (BMP) pathway which is responsible for the development and repair of ... This causes a change in the critical glycine-serine activation domain of the protein which will cause the protein to bind its ... Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ACVR1 gene; also known as ALK-2 (activin ...
This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, ... a bone morphogenetic protein antagonist abundantly expressed in the kidney". Biochemical and Biophysical Research ... Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene. This gene is a member of the ... Goto M, Eddy EM (October 2004). "Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the ...
2004). "Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1". J. Biol. Chem. 279 (2): 980-6. ... This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth ... 2006). "A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment". J. Biol. Chem. 281 (12 ... 2006). "DMP1 Depletion Decreases Bone Mineralization In Vivo: An FTIR Imaging Analysis". J. Bone Miner. Res. 20 (12): 2169-77. ...
"Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain". J. Biol. Chem. 275 (30): ... "HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium". Arch. Immunol ... The protein encoded by this gene is the alpha-3 chain of laminin 5, which is a complex glycoprotein composed of three subunits ... Laminin subunit alpha-3 is a protein that in humans is encoded by the LAMA3 gene. Laminins are basement membrane components ...
"Bone Morphogenetic Protein-2 Inhibits Differentiation and Mineralization of Cementoblasts in vitro". Journal of Dental Research ... Unlike those in bone, however, these canals in cementum do not contain nerves, nor do they radiate outward. Instead, the canals ... Thus cementoblasts resemble bone-forming osteoblasts but differ functionally and histologically. The cells of cementum are the ... Each cementocyte lies in its lacuna (plural, lacunae), similar to the pattern noted in bone. These lacunae also have canaliculi ...
"Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038/ ... The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This RNA binding ... "Entrez Gene: ZFP36L1 zinc finger protein 36, C3H type-like 1". Weichhart T (2018). "mTOR as Regulator of Lifespan, Aging, and ... "The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression". ...
2000). "Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain". J. Biol. Chem. 275 ... Laminin subunit gamma-2 is a protein that in humans is encoded by the LAMC2 gene. Laminins, a family of extracellular matrix ... Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. ... 2001). "Involvement of activator protein 1 complexes in the epithelium-specific activation of the laminin gamma2-chain gene ...
It induces human osteoblast differentiation through bone morphogenetic protein-2/extracellular signal-regulated kinase 1/2 ... induces human osteoblast differentiation through bone morphogenetic protein-2/extracellular signal-regulated kinase 1/2 pathway ... 7 (1): 42-48. doi:10.1002/(SICI)1099-1565(199601)7:1. 3.0.CO;2-K. S2CID 95953333. Tyukavkina, N. A.; Medvedeva, S. A.; Ivanova ... 58 (1): 427-433. doi:10.1021/jf903033m. PMID 20000402. S2CID 28304488. Hsu, Ya-Ling; Liang, Hsin-Lin; Hung, Chih-Hsing; Kuo, Po ...
... is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development". Proceedings of the ... This gene encodes a protein with similarity to follistatin, an BMP-4-binding protein. It binds to BMP-4 and TGF-β1, but not ... Tanaka M, Ozaki S, Osakada F, Mori K, Okubo M, Nakao K (Sep 1998). "Cloning of follistatin-related protein as a novel ... FSTL1 protein seems to have a cardioprotective role. FSTL1 attenuated hypertrophy following pressure overload and prevented ...
SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play ... Like many other TGFβ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins ( ... Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SMAD5 gene. SMAD5, ... It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. ...
When a bone morphogenetic protein binds to a receptor (BMP type 1 receptor kinase) it causes SMAD9 to interact with SMAD anchor ... SMAD9 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. There are ... The SMAD proteins are homologs of both the drosophila protein, mothers against decapentaplegic (MAD) and the C. elegans protein ... Mothers against decapentaplegic homolog 9 also known as SMAD9, SMAD8, and MADH6 is a protein that in humans is encoded by the ...
King FW, Shtivelman E (2004). "Inhibition of nuclear import by the proapoptotic protein CC3". Mol. Cell. Biol. 24 (16): 7091- ... a protein associated with metastasis suppression". Cell. Mol. Life Sci. 57 (5): 851-8. doi:10.1007/s000180050047. PMID 10892349 ... "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano ...
Amano S, Scott IC, Takahara K, et al. «Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 ... Mrowiec T, Melchar C, Górski A «HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins ... 1-12. tipus I (COL1A1, COL1A2) · tipus II (COL2A1) · tipus III · tipus IV (COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6) · ... and mitogen-activated protein kinase can regulate epithelial cell proliferation.». Mol. Biol. Cell, vol. 10, 2, 1999, pàg. 259- ...
... which is an antagonistic protein to bone morphogenic protein 4. This gene encodes an antagonist of bone morphogenetic protein 4 ... Chen D, Zhao M, Mundy GR (December 2004). "Bone morphogenetic proteins". Growth Factors. 22 (4): 233-41. doi:10.1080/ ... Gazzerro E, Canalis E (June 2006). "Bone morphogenetic proteins and their antagonists". Reviews in Endocrine & Metabolic ... a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating ...
Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is encoded ... Li C, Yang X, He Y, Ye G, Li X, Zhang X, Zhou L, Deng F (2012). "Bone morphogenetic protein-9 induces osteogenic ... Mi LZ, Brown CT, Gao Y, Tian Y, Le VQ, Walz T, Springer TA (March 2015). "Structure of bone morphogenetic protein 9 procomplex ... Fong D, Bisson M, Laberge G, McManus S, Grenier G, Faucheux N, Roux S (Apr 2013). "Bone morphogenetic protein-9 activates Smad ...
GDF6 interacts with bone morphogenetic proteins to regulate ectoderm patterning, and controls eye development. GDF8 is now ... Hino J, Kangawa K, Matsuo H, Nohno T, Nishimatsu S (2004). "Bone morphogenetic protein-3 family members and their biological ... Truksa J, Peng H, Lee P, Beutler E (2006). "Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression ... "Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons". Proc Natl Acad Sci USA. 102 (19 ...
Another family of metalloproteases, the Bone Morphogenetic Protein 1/Tolloid-like family, releases the c-terminal endorepellin ... Cartilage and bone development have proven to be dependent upon perlecan expression. The protein becomes visible by ... that the driving force behind heparanase and chondroitinase activation of osteogenesis is release of bone morphogenetic protein ... chondroitin sulfate signaling enhances mesenchymal stem cell-derived osteogenic differentiation via bone morphogenetic protein ...
... induces human osteoblast differentiation through bone morphogenetic protein-2/extracellular signal-regulated kinase 1/2 pathway ... This is due to the tendency of tannins to react with proteins, such as the ones found in saliva. In food and wine pairing, ... proteins and lipids from oxidative damage pursuant to Article 13(1) of Regulation (EC) No 1924/20061". EFSA Journal. 8 (2): ... foods that are high in proteins (such as red meat) are often paired with tannic wines to minimize the astringency of tannins. ...
This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological ... SMAD1 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. GRCm38: ... Protein at the US National Library of Medicine Medical Subject Headings (MeSH) SMAD1+protein,+human at the US National Library ... This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and ...
... a heparin binding bone morphogenetic protein, with type IV collagen". The Journal of Biological Chemistry. 265 (28): 17281-4. ... Type IV collagen is the major structural component of basement membranes, which contains two or three COL4A1 proteins. Thus, ... Hinek A (July 1994). "Nature and the multiple functions of the 67-kD elastin-/laminin binding protein". Cell Adhesion and ... Accordingly, it was demonstrated that protein expression of collagen type IV in human vascular smooth muscle cells is regulated ...
Namkoong H, Shin SM, Kim HK, Ha SA, Cho GW, Hur SY, Kim TE, Kim JW (2006). "The bone morphogenetic protein antagonist gremlin 1 ... Gremlin1 (Grem1) is known for its antagonistic interaction with bone morphogenetic proteins (BMPs) in the TGF beta signaling ... "Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor ... 12, 23 GREM1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) GREM2+protein,+human at the ...
... collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases". J. Biol. Chem. 277 (7): 5596-602 ... Collagen alpha-2(V) chain is a protein that in humans is encoded by the COL5A2 gene. This gene encodes an alpha chain for one ... 1 (1): 29-39. PMC 5952197. PMID 1820205. Myers JC, Loidl HR, Seyer JM, Dion AS (1985). "Complete primary structure of the human ... 1 (1): 25-34. doi:10.1016/S1097-2765(00)80004-0. PMID 9659900. Richards AJ, Martin S, Nicholls AC, et al. (1999). "A single ...
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins ... Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA ... Ceramide synthase 1 also known as LAG1 longevity assurance homolog 1 is an enzyme that in humans is encoded by the CERS1 gene. ... "Ceramide synthase 1". EBI.ac.uk. EMBL-EBI. 2014. Retrieved 16 February 2014. Riebeling C, Allegood JC, Wang E, Merrill AH Jr, ...
... bone morphogenetic protein‐6 (BMP‐6) vector. She found BMP‐6 to be osteo-inductive in vivo resulting in acceleration of bone ... Her research indicated that transduction of BMDMSC with bone morphogenetic proteins‐2 or ‐6 can accelerate osteogenic ... "Mesenchymal Stem Cell-mediated Gene Delivery of Bone Morphogenetic Protein-2 in an Articular Fracture Model". Molecular Therapy ... mediated osteogenic differentiation of stem cells by bone morphogenetic proteins‐2 or ‐6". Journal of Orthopaedic Research. 24 ...
2001). "Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct ... Tolloid-like protein 2 is a protein that in humans is encoded by the TLL2 gene. This gene encodes an astacin-like zinc- ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63-70. doi: ... Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. GRCh38: Ensembl ...
Shim S, Bae N, Han JK (July 2002). "Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/ ... Zinc finger protein 423 is a protein that in humans is encoded by the ZNF423 gene. The protein encoded by this gene is a ... "ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression". The Journal ... OAZ+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ...
This linkage is further evidenced by the fact that two of the genes, HAO1 and BMP2, affecting medullary bone (the part of the ... The HBB gene encodes information to make the beta-globin subunit of hemoglobin, which is the protein red blood cells use to ... Foods with high levels of protein must be avoided. These include breast milk, eggs, chicken, beef, pork, fish, nuts, and other ... Both males and females with larger combs have higher bone density and strength, which allows females to deposit more calcium ...
Chen D, Zhao M, Mundy GR (December 2004). "Bone morphogenetic proteins". Growth Factors 22 (4): 233-41. PMID 15621726. doi: ... Kawamura C, Kizaki M, Ikeda Y (2003). "Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells.". Leuk. ... "Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine ... Koštani morfogenetički protein 2 ili BMP-2 pripada TGF-β superfamiliji proteina.[1] ...
Receptor protein serine/threonine kinase (EC 2.7.11.30). *Bone morphogenetic protein receptors *BMPR1 ... The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene ... protein kinase activity. • kinase activity. • protein serine/threonine kinase activity. • cyclin-dependent protein serine/ ... protein binding. • ATP binding. • cyclin binding. • cyclin-dependent protein serine/threonine kinase activity. • macromolecular ...
In general, proteins fold into discrete units that perform distinct cellular functions, but some proteins are also capable of ... Adult stem cells like bone marrow stem cells have also shown a potential to differentiate into cardiac competent cells when ... The first way is post translational modification of the amino acids that make up histone proteins. Histone proteins are made up ... thereby reducing that protein's activity. In PSI+ cells, the loss of the Sup35 protein (which is involved in termination of ...
... is due to the upregulation of bone morphogenetic proteins (Bmps). During embryonic development, the gene controlling Bmp ... The finger bones of bats are much more flexible than those of other mammals, owing to their flattened cross-section and to low ... The patagium is the wing membrane; it is stretched between the arm and finger bones, and down the side of the body to the hind ... Kirkpatrick, S. J. (1994). "Scale effects on the stresses and safety factors in the wing bones of birds and bats". Journal of ...
Mutations in several genes have been associated with this condition[24][25] these include bone morphogenetic protein receptor ... 37 (1): 67-119. doi:10.1093/eurheartj/ehv317. PMID 26320113.. *^ a b c d e f g h i j k l McLaughlin VV, Archer SL, Badesch DB, ... This in turn leads to increased cAMP-dependent protein kinase or PKA (protein kinase A) activity, ultimately promoting ... 44 (1): 1-10. doi:10.1165/rcmb.2009-0388TR. PMID 20448055.. *^ a b c d e f Wood SF (January 1986). "Astemizole and terfenadine ...
Bone morphogenetic proteins (BMPs) are a subgroup of TGF-β superfamily that can induce bone and cartilage formation as well as ... Ligaments join one bone to bone, while tendons connect muscle to bone for a proper functioning of the body. ... In this process, osteocytes infiltrate the tendon and lay down bone as they would in sesamoid bone such as the patella. In ... 87A (1): 187-202. doi:10.2106/JBJS.D.01850. PMID 15634833.. *^ a b c d e f Wang, J. H. C., (2006). "Mechanobiology of tendon". ...
In protein-ligand binding, the ligand is usually a molecule which produces a signal by binding to a site on a target protein. ... putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer ... Teif VB, Rippe K (October 2010). "Statistical-mechanical lattice models for protein-DNA binding in chromatin". Journal of ... The conformation of a receptor protein composes the functional state. Ligands include substrates, inhibitors, activators, and ...
Zinc finger E-box-binding homeobox 2 is a protein that in humans is encoded by the ZEB2 gene. The ZEB2 protein is a ... ZEB2 protein has 8 zinc fingers and 1 homeodomain. The structure of the homeodomain shown on the right. ZEB2 interacts with ... Mutations of the gene can cause the gene to produce nonfunctional ZEB2 proteins or inactivate the function gene as a whole. ... These deficits of ZEB2 protein interferes with the development of many organs. Many of the symptoms can be explained by the ...
Pregnancy-associated plasma protein A. *Bone morphogenetic protein 1. *Lysostaphin. *Insulin-degrading enzyme ... It is translocated into the host cell cytoplasm where it cleaves the host protein SNAP-25, a member of the SNARE protein family ... Botulinum toxin (Botox) is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species.[1] It ... the toxin cleaves SNARE proteins (proteins that mediate vesicle fusion, with their target membrane bound compartments) meaning ...
... and bone morphogenetic proteins.[45] Evidence suggests that bone cells produce growth factors for extracellular storage in the ... Bone marrow[edit]. Bone marrow, also known as myeloid tissue in red bone marrow, can be found in almost any bone that holds ... Bone volume[edit]. Bone volume is determined by the rates of bone formation and bone resorption. Recent research has suggested ... Bone tissue is a mineralized tissue of two types, cortical bone and cancellous bone. Other types of tissue found in bones ...
Growth differentiation factor 11 (GDF11) also known as bone morphogenetic protein 11 (BMP-11) is a protein that in humans is ... GDF11 acts as a cytokine and its molecular structure is identical in humans, mice and rats.[6] The bone morphogenetic protein ... "GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced ... Signaling peptide/protein receptor modulators. Growth factor receptor modulators. Cytokine receptor modulators. ...
Receptor protein serine/threonine kinase (EC 2.7.11.30). *Bone morphogenetic protein receptors *BMPR1 ... protein kinase activity. • PDZ domain binding. • SH3 domain binding. • scaffold protein binding. • metal ion binding. • kinase ... protein serine/threonine kinase activity. • GO:0001948 protein binding. • ATP binding. • Rho GTPase binding. ... Displaying a distinctive protein organization, this protein defines a separate class of rho partners.[7] Using a cloning ...
Pregnancy-associated plasma protein A. *Bone morphogenetic protein 1. *Lysostaphin. *Insulin-degrading enzyme ... In biology and chemistry, gelatinase is a proteolytic enzyme that allows a living organism to hydrolyse gelatin[1] into its sub ...
The decapentaplegic Vg-related (DVR) related subfamily (including the bone morphogenetic proteins and the growth ... These proteins interact with a conserved family of cell surface serine/threonine-specific protein kinase receptors, and ... Signaling peptide/protein receptor modulators. Growth factor receptor modulators. Cytokine receptor modulators. ... Human genes encoding proteins that contain this domain include:. AMH; ARTN; BMP10; BMP15; BMP2; BMP3; BMP4; BMP5; BMP6; BMP7; ...
Receptor protein serine/threonine kinase. *Bone morphogenetic protein receptors *BMPR1. *BMPR1A. *BMPR1B ... Guanylyl cyclase activator (protein). References[edit]. *^ Sakurai K.; Chen J.; Kefalov V. (2011). "Role of guanylate cylcase ... Guanylate cyclase is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and ... Depending on cell type, it can drive adaptive/developmental changes requiring protein synthesis. In smooth muscle, cGMP is the ...
Inhibition of TGF-β and BMP (bone morphogenetic protein) signaling can efficiently induce neural tissue from pluripotent stem ... The Trk proteins act as receptors for NGF and related factors. Trk is a receptor tyrosine kinase. Trk dimerization and ... This is due to the action of BMP4 (a TGF-β family protein) that induces ectodermal cultures to differentiate into epidermis. ... GDNF: Glial derived neurotrophic factor is a member of the TGFb family of proteins, and is a potent trophic factor for striatal ...
This can occur because shark teeth are not attached to a bone, but instead are developed within a bony cavity.[64] It has been ... Neural cells, for example, express growth-associated proteins, such as GAP-43, tubulin, actin, an array of novel neuropeptides ... "Morphogenetic mechanisms in the cyclic regeneration of hair follicles and deer antlers from stem cells". BioMed Research ... regeneration has been observed in the tails and maxillary bone of crocodiles and adult neurogenesis has also been noted.[99][ ...
Receptor protein serine/threonine kinase (EC 2.7.11.30). *Bone morphogenetic protein receptors *BMPR1 ... This protein-related article is a stub. You can help Wikipedia by expanding it.. *v ... protein binding. • metal ion binding. • oxidoreductase activity. • carboxy-lyase activity. • 3-methyl-2-oxobutanoate ... 14 (1): 37-44. doi:10.1007/BF01804386. PMID 1861457.. *. Fisher CR, Fisher CW, Chuang DT, Cox RP (1991). "Occurrence of a ...
2008). "GLI2-specific transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human ... and bone morphogenetic proteins". Endocrinology. 147 (7): 3586-97. doi:10.1210/en.2006-0089. PMID 16627583. Grusch M, Drucker C ... It has inhibitory action on bone morphogenic proteins (BMPs); BMPs induce the ectoderm to become epidermal ectoderm. Inhibition ... Follistatin also known as activin-binding protein is a protein that in humans is encoded by the FST gene. Follistatin is an ...
Bone morphogenetic protein (rhBMP) should not be routinely used in any type of anterior cervical spine fusion, such as with ... 37 (1): 67-76. doi:10.1097/brs.0b013e31820cccfb. PMID 21311399.. *^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ... Woo, EJ (Oct 2012). "Recombinant human bone morphogenetic protein-2: adverse events reported to the Manufacturer and User ... Life-threatening Complications Associated with Recombinant Human Bone Morphogenetic Protein in Cervical Spine Fusion". fda.gov ...
The lack of these factors result in a decreased production of bone morphogenetic protein (BMP), which translates into a ... synaptic vesicle proteins, and channel proteins. A deficiency in the proper development of these proteins can cause the neural ... stretch in the protein. The mutated Htt protein affects an individual's proper neural functions by inhibiting the action of ... that binds to the TATA box along with 13 other proteins that bind to TBP. The TATA box binding proteins also include the ...
... astrocytes were generated by exposing human glial precursor cells to bone morphogenetic protein (Bone morphogenetic protein is ... WNTs and bone morphogenetic proteins (BMPs), provide positional information to developing macroglial cells through morphogen ... with the bone protein and human glial cells combined, they promoted significant recovery of conscious foot placement, axonal ... In response to nerve damage, heat shock proteins (HSP) are released and can bind to their respective TLRs, leading to further ...
... bone morphogenetic protein, and growth differentiation factor belong to the TGF-β protein superfamily.[9] ... bone growth), to behave as an agonist of the receptor and to induce hyperactive bone growth.[21] On 2 September 2015, Regeneron ... The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to ... Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Identified ...
... and bone morphogenetic protein BMP4. FGF10 is seen to have the most prominent role. FGF10 is a paracrine signalling molecule ... Other proteins with elevated expression in the lung are the dynein protein DNAH5 in ciliated cells, and the secreted SCGB1A1 ... The highest expression of lung specific proteins are different surfactant proteins,[18] such as SFTPA1, SFTPB and SFTPC, and ... Gene and protein expression[edit]. Further information: Bioinformatics § Gene and protein expression ...
Pregnancy-associated plasma protein A. *Bone morphogenetic protein 1. *Lysostaphin. *Insulin-degrading enzyme ... It is translocated into the host cell cytoplasm where it cleaves the host protein SNAP-25, a member of the SNARE protein family ... Botulinum toxin (BTX) or Botox is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species.[1] ... Botulinum toxin exerts its effect by cleaving key proteins required for nerve activation. First, the toxin binds specifically ...
Examples of such proteins include bone morphogenetic proteins and cadherins. Expression of these proteins is essential to ... Bone morphogenetic protein 4, or BMP4, is a transforming growth factor that causes the cells of the ectoderm to differentiate ... Cell signaling and essential proteins[edit]. Critical to the proper folding and function of the neural plate is N-cadherin, a ... In a newly formed neural plate, PAX3 mRNA, MSX1 mRNA, and MSX1/MSX2 proteins are expressed mediolaterally.[9] When the neural ...
"Mycoplasma infection transforms normal lung cells and induces bone morphogenetic protein 2 expression by post-transcriptional ... The protein also causes the growth, morphology, and the gene expression of the cells to change, causing them to become a more ... Prostate cancer: p37, a protein encoded for by M. hyorhinis, has been found to promote the invasiveness of prostate cancer ... P1 is a membrane associated protein that allows adhesion to epithelial cells. The P1 receptor is also expressed on erythrocytes ...
Activin, inhibin and a number of other structurally related proteins such as anti-Müllerian hormone, bone morphogenetic protein ... and growth differentiation factor belong to the TGF-β protein superfamily. The activin and inhibin protein complexes are both ... In addition, both complexes are derived from the same family of related genes and proteins but differ in their subunit ... The mutation in ACVR1 causes activin A, which normally acts as an antagonist of the receptor and blocks osteogenesis (bone ...
Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely ... BMP1 belongs to the peptidase M12A family of bone morphogenetic proteins (BMPs). It induces bone and cartilage development. ... Bone morphogenetic protein 1, also known as BMP1, is a protein which in humans is encoded by the BMP1 gene. There are seven ... "Entrez Gene: BMP1 bone morphogenetic protein 1". Tabas JA, Zasloff M, Wasmuth JJ, Emanuel BS, Altherr MR, McPherson JD, Wozney ...
Bone morphogenetic protein type I receptors are single pass, type I transmembrane proteins. They belong to a class of receptor ... Bone+Morphogenetic+Protein+Receptors,+Type+I at the US National Library of Medicine Medical Subject Headings (MeSH) Biology ... serine/threonine kinases that bind members of the TGF beta superfamily of ligands-the Bone morphogenetic proteins. The three ...
bmp7.1 (bone morphogenetic protein 7, gene 1) expressed in Xenopus laevis embryo via in situ hybridization, stage 28, lateral ... bmp7, bmp-7, op-1. X.laevis. Throughout NF stage 28. Image source: Community submitted. Larger Image. Printer Friendly View. ...
Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 are members of the TGF-beta gene family most closely related to the Drosophila ... Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse ... Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse ... Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse ...
... like proteins BMP2, BMP4 (vertebrates) and decapentaplegic (arthropods). More recently, it has become apparent that the BMP1/ ... TLD-like proteinases are activators of a broader subset of the TGFbeta superfamily of proteins, with implications that these ... proteinases may be key in orchestrating the formation of ECM with growth factor activation and BMP signaling in morphogenetic ... bone morphogenetic protein 1 (BMP1) was shown to provide the activity necessary for proteolytic removal of the C-propeptides of ...
Like other members of the transforming growth factor-beta super family, OP-1 might play an inductive role in the early embryo. ... Our results suggest that pluripotent human EC cells differentiate in response to OP-1 and that this factor can modulate the ... growth factor-beta super family closely related to the bone morphogenetic proteins and also known as bone morphogenetic protein ... whereas the expression of several bone morphogenetic proteins including OP-1 is developmentally regulated in mammalian embryos ...
Fluorescent Proteins, RNAi, Viral Packaging and Protein expression. ... a secreted metalloprotease requiring calcium and needed for cartilage and bone formation. BMP1 is capable of inducing the ...
Rat Bone Morphogenetic Protein 1 ELISA Kit-NP_006120.1 (MBS021022) product datasheet at MyBioSource, ELISA Kits ... Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not ... NCBI Protein Information. bone morphogenetic protein 1; procollagen C-proteinase; mammalian tolloid protein; procollagen C- ... Kit for analyzing the presence of the Bone Morphogenetic Protein 1 (BMP1) ELISA Kit target analytes in biological samples. The ...
The lyophilized protein should be reconstituted with distilled, sterile water to a concentration of 0.1-1.0 mg/ml. For further ... The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted ... BMP-14 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the BMP-14 ... Recombinant human BMP-14 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids. ...
... also known as bone morphogenetic protein-7) is a member of the bone morphogenetic protein family. Bone morphogenetic proteins ... also known as bone morphogenetic protein-7) is a member of the bone morphogenetic protein family. Bone morphogenetic proteins ... also known as bone morphogenetic protein-7) is a member of the bone morphogenetic protein family. Bone morphogenetic proteins ... also known as bone morphogenetic protein-7) is a member of the bone morphogenetic protein family. Bone morphogenetic proteins ...
YWHAH protein binding site for gremlin 1 was located between residues 61-80 and gremlin 1 binding site for YWHAH was found to ... Over-expressed gremlin 1 functions by interaction with YWHAH. Therefore, Gremlin 1 and its binding protein YWHAH could be good ... Gremlin 1 may play an oncogenic role especially in carcinomas of the uterine cervix, lung, ovary, kidney, breast, colon, ... To understand the tumorigenesis pathway of identified gremlin 1 protein, we performed a yeast two-hybrid screen, GST pull down ...
Bone morphogenetic proteins (BMPs) are multifunctional proteins, structurally related to transforming growth factor-β (TGF-β) ... N2 - Bone morphogenetic proteins (BMPs) are multifunctional proteins, structurally related to transforming growth factor-β (TGF ... AB - Bone morphogenetic proteins (BMPs) are multifunctional proteins, structurally related to transforming growth factor-β (TGF ... abstract = "Bone morphogenetic proteins (BMPs) are multifunctional proteins, structurally related to transforming growth factor ...
N2 - Bone morphogenetic protein (BMP) antagonists regulate the pleiotropic actions of BMPs by binding to BMPs. We previously ... AB - Bone morphogenetic protein (BMP) antagonists regulate the pleiotropic actions of BMPs by binding to BMPs. We previously ... Bone morphogenetic protein (BMP) antagonists regulate the pleiotropic actions of BMPs by binding to BMPs. We previously ... abstract = "Bone morphogenetic protein (BMP) antagonists regulate the pleiotropic actions of BMPs by binding to BMPs. We ...
... the first clinical reports on bone regeneration by two recombinant human bone morphogenetic proteins (rhBMPs), BMP-2 and BMP-7 ... also named osteogenic protein-1, OP-1) have been published ... ... Bone morphogenetic proteins in human bone regeneration. * ... Recently, the first clinical reports on bone regeneration by two recombinant human bone morphogenetic proteins (rhBMPs), BMP-2 ... The information may provide clues as to how the performance of recombinant human BMP as bone-graft substitute in humans can be ...
Recombinant Human Bone morphogenetic protein 2(BMP2) von Cusabio bei SZABO-SCANDIC erhältlich. Weiteres zu Proteine & Peptide ... Organism: Homo sapiens (Human). Function: Induces cartilage and bone formation. Subcellular Location: Secreted. Protein ...
Protein Coding), Bone Morphogenetic Protein 1, including: function, proteins, disorders, pathways, orthologs, and expression. ... Protein Symbol:. P13497-BMP1_HUMAN. Recommended name:. Bone morphogenetic protein 1 Protein Accession:. P13497. Secondary ... Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not ... BMP1 (Bone Morphogenetic Protein 1) is a Protein Coding gene. Diseases associated with BMP1 include Osteogenesis Imperfecta, ...
What is bone morphogenic protein-1? Meaning of bone morphogenic protein-1 medical term. What does bone morphogenic protein-1 ... Looking for online definition of bone morphogenic protein-1 in the Medical Dictionary? bone morphogenic protein-1 explanation ... Bone morphogenetic protein 9. *bone morphogenetic protein and associated noncollagenous proteins. *Bone Morphogenetic Protein I ... bone morphogenetic protein-1. (redirected from bone morphogenic protein-1) bone morphogenetic protein-1. A metalloproteinase ...
Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Bone Morphogenetic Protein 1 (BMP1 ... Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Bone Morphogenetic Protein 1 (BMP1 ... This assay has high sensitivity and excellent specificity for detection of Bone Morphogenetic Protein 1 (BMP1). ... No significant cross-reactivity or interference between Bone Morphogenetic Protein 1 (BMP1) and analogues was observed. ...
The Drosophila dorsal-ventral patterning gene tolloid is related to human bone morphogenetic protein 1. Cell. 1991 Nov 1;67(3): ... tld sequence is 41% identical to human bone morphogenetic protein 1 (BMP-1); the closest members to dpp within the TGF-β ... tld sequence is 41% identical to human bone morphogenetic protein 1 (BMP-1); the closest members to dpp within the TGF-β ... tld sequence is 41% identical to human bone morphogenetic protein 1 (BMP-1); the closest members to dpp within the TGF-β ...
The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair. ... Purified BMP-2 proteins and processes for producing them are disclosed. ... wherein BMP is bone morphogenic protein) proteins and processes for obtaining them. These proteins may be used to induce bone ... Pharmaceutical compositions comprising bone morphogenetic protein monomers for inhibiting bone formation. US7371377. Jun 19, ...
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating ... Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron. ... 1.Division of Basic Stem Cell Biology, Department of Stem Cell Biology and Medicine, Graduate School of Medical SciencesKyushu ... Megova M, Drabek J, Koudelakova V, Trojanec R, Kalita O, Hajduch M. Isocitrate dehydrogenase 1 and 2 mutations in gliomas. J ...
Two protein-coding genes were identified in qBW_2 (Table 4, Fig. 5a). Bone morphogenetic protein 1 (BMP1) is a ... Hopkins D, Keles S. Ds: the bone morphogenetic protein 1/Tolloid-like metalloproteinases. Matrix Biol. 2007;26(7):508-23. ... Wardle FC, Welch JV, Dale L. Bone morphogenetic protein 1 regulates dorsal-ventral patterning in early Xenopus embryos by ... 5b). This QTL interval identified many zinc finger proteins (ZFPs), such as ZFP729, ZFP668, and ZFP37 (Table 4). ZFP is a ...
KLF4 re-expression in established KLF4 null bone tumors inhibits their osteolytic effects, preventing bone fractures and ... Here, we show that the anti-tumorigenic effect of KLF4 extends to PC3 human prostate cancer cells growing in the bone. We ... inducing an osteogenic response with new bone formation. In addition to these profound biological changes, KLF4 also induces a ... KLF4 re-expression immediately after their intra-femoral inoculation blocks tumor development and preserves a normal bone ...
... bone morphogenetic protein-2, and demineralized bone matrix on local bone formation in the rat critical-size defect model. en_ ... bone morphogenetic protein-2, and demineralized bone matrix on local bone formation in the rat critical-size defect model. ...
The bone morphogenetic protein 1/Tolloid-like metalloproteinases. Matrix Biol . 2007; 26: 508-523. [CrossRef] [PubMed] ... Isolation and maturation to an active form by bone morphogenetic protein-1. J Biol Chem . 2001; 276: 48944-48949. [CrossRef] [ ... Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3. J Biol Chem . 2011; 286: 29014-29025. [ ... Bone-morphogenetic protein-1 (BMP1), also known as procollagen C-proteinase, is a zinc protease that converts secreted ...
Cheng, J. T., Yeh, C. H., Chang, C. K., Cheng, K. C., Li, Y. X., & Zhang, Y. W. (2011). Role of bone morphogenetic proteins-7 ( ... Bone morphogenetic proteins-7 (BMP-7) is produced merit in protection of DN. The role of BMP-7 in DangGui-induced renal ... Cheng, JT, Yeh, CH, Chang, CK, Cheng, KC, Li, YX & Zhang, YW 2011, Role of bone morphogenetic proteins-7 (BMP-7) in the renal ... Bone morphogenetic proteins-7 (BMP-7) is produced merit in protection of DN. The role of BMP-7 in DangGui-induced renal ...
... and other members of BMP family such as BMP-2 and cartilage-derived morphogenetic protein-1/growth and differentiation factor-5 ... BACKGROUNDOsteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7), a member of the transforming growth factor-beta ... Characterization of receptors for osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7) in rat kidneys.. Kidney Int. ... Moreover, in situ hybridization and immunostaining methods have shown localization of mRNA transcripts and the protein for BMP ...
T1 - Transforming growth factor-β2 induces expression of biologically active bone morphogenetic protein-1 in human trabecular ... keywords = "Bone morphogenetic protein 1, Trabecular meshwork, Transforming growth factor beta 2", ... Transforming growth factor-β2 induces expression of biologically active bone morphogenetic protein-1 in human trabecular ... title = "Transforming growth factor-β2 induces expression of biologically active bone morphogenetic protein-1 in human ...
Estimated glomerular filtration rate in sickle cell anemia is associated with polymorphisms of bone morphogenetic protein ... and Bone Morphogenetic Protein Receptor type-1B (BMPR1B) [rs17022863 (A,G), rs4331783 (A,G) and rs1470409 (A,G)] genes in 75 ... Okeke Chinedu 1 , Wouitchékpo Vincent Tonassé 1 , Dulcinéia Martins Albuquerque 2 , Igor de Farias Domingos 3 , Aderson da ... Okeke Chinedu 1 , Wouitchékpo Vincent Tonassé 1 , Dulcinéia Martins Albuquerque 2 , Igor de Farias Domingos 3 , Aderson da ...
Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 ... Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 ... Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 ... title = "Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin ...
  • Bone morphogenetic protein 1, also known as BMP1, is a protein which in humans is encoded by the BMP1 gene. (wikipedia.org)
  • BMP1 belongs to the peptidase M12A family of bone morphogenetic proteins (BMPs). (wikipedia.org)
  • The BMP1 locus encodes a protein that is capable of inducing formation of cartilage in vivo. (wikipedia.org)
  • Although other bone morphogenetic proteins are members of the TGF-beta superfamily, BMP1 encodes a protein that is not closely related to other known growth factors. (wikipedia.org)
  • BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. (wikipedia.org)
  • PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the procollagen C-endopeptidase enhancer protein. (wikipedia.org)
  • A decade ago, bone morphogenetic protein 1 (BMP1) was shown to provide the activity necessary for proteolytic removal of the C-propeptides of procollagens I-III: precursors of the major fibrillar collagens. (semanticscholar.org)
  • Dentin sialophosphoprotein (DSPP) is cleaved into its two natural dentin matrix products by three isoforms of bone morphogenetic protein-1 (BMP1). (semanticscholar.org)
  • MBS021022 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Bone Morphogenetic Protein 1 (BMP1) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • BMP1 (Bone Morphogenetic Protein 1) is a Protein Coding gene. (genecards.org)
  • A metalloproteinase encoded by BMP1 on chromosome 8p21, which cleaves the C-terminal propeptides of procollagen I, II and III, inducing cartilage and bone formation. (thefreedictionary.com)
  • This assay has high sensitivity and excellent specificity for detection of Bone Morphogenetic Protein 1 (BMP1). (biotecnika.org)
  • No significant cross-reactivity or interference between Bone Morphogenetic Protein 1 (BMP1) and analogues was observed. (biotecnika.org)
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Bone Morphogenetic Protein 1 (BMP1) were tested 20 times on one plate, respectively. (biotecnika.org)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Bone Morphogenetic Protein 1 (BMP1) were tested on 3 different plates, 8 replicates in each plate. (biotecnika.org)
  • Bone morphogenic protein 1 (BMP1) is an enzyme responsible for the cleavage and maturation of growth factors and ECM proteins. (arvojournals.org)
  • qPCR was used to determine BMP1 mRNA expression and WB results were used to determine BMP1 protein expression. (arvojournals.org)
  • Human TM cells expressed mRNA and protein for BMP1. (arvojournals.org)
  • TGF-β2 induction of BMP1 may be responsible for increased processing of growth factors and ECM proteins into their mature forms, resulting in TM stiffness and resistance to ECM degradation. (arvojournals.org)
  • Bone-morphogenetic protein-1 (BMP1), also known as procollagen C-proteinase, is a zinc protease that converts secreted precursor pro-proteins into mature, functional proteins. (arvojournals.org)
  • Attenuated BMP1 function compromises osteogenesis, leading to bone fragility in humans and zebrafish. (proteopedia.org)
  • It was initially discovered to work like other BMPs by inducing bone and cartilage development. (wikipedia.org)
  • Bone morphogenetic proteins (BMPs) are multifunctional proteins, structurally related to transforming growth factor-β (TGF-β) and activin. (elsevier.com)
  • Bone morphogenetic protein (BMP) antagonists regulate the pleiotropic actions of BMPs by binding to BMPs. (elsevier.com)
  • All data suggest that Ng1 protein plays an important role in the embryonic bone formation by differentially regulating BMPs. (elsevier.com)
  • Although both BMPs were able to support bone regeneration, a significant variation in individual response was observed with both proteins. (mendeley.com)
  • The use of bone morphogenetic proteins (BMPs) represents another possibility in the treatment of exposed pulps with no contact with aggressive agents and free from undesirable effects to maintain pulp vitality. (bvsalud.org)
  • El uso de proteínas óseas morfogenéticas (BMPs), representa otra posibilidad en el tratamiento de pulas expuestas sin la presencia de agentes agresores, libre principalmente de los efectos indeseables a la mantención de la vitalidad pulpar. (bvsalud.org)
  • Completing the PIR series, this volume summarizes the major advances made in the local and systemic use of bone morphogenetic proteins (BMPs). (weltbild.de)
  • and the potential systemic use of BMPs for tissues beyond bone. (weltbild.de)
  • Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor beta (TGFbeta) superfamily. (nih.gov)
  • BMPs also play an important role in postnatal bone formation. (nih.gov)
  • The activity of BMPs was first identified in the 1960s (Urist, M.R. (1965) "Bone formation by autoinduction", Science 150, 893-899), but the proteins responsible for bone induction remained unknown until the purification and sequence of bovine BMP-3 (osteogenin) and cloning of human BMP-2 and 4 in the late 1980s (Wozney, J.M. et al. (nih.gov)
  • Publications] Sasano.Y: 'BMPs induce direct bone formation in ectopic sites independent in vivo and in vitro' The Anatomical Record. (nii.ac.jp)
  • Bone morphogenetic proteins (BMPs) belong to the superfamily of transforming growth factor-β proteins. (portlandpress.com)
  • BMPs are evolutionarily conserved secreted growth factors that, in vertebrates, are divided into several subgroups based on phylogenetic analysis [ 2 ] ( Table 1 ). (portlandpress.com)
  • BMPs are translated as pre-proteins with a prodomain. (portlandpress.com)
  • Bone morphogenetic proteins (BMPs) represent a large subgroup of the transforming growth factor (TGF)-β superfamily. (physiology.org)
  • GREMLIN 1 Expression Is Elevated in BCC, and BMPs Are Highly Expressed by BCC Tumors. (biology-online.org)
  • Bone morphogenetic proteins (BMPs) are important signalling molecules that were first identified by their ability to induce bone and cartilage, and subsequently were shown to be pleiotropic cytokines controlling a wide variety of biological responses during early development, skeletogenesis and homoeostasis of several tissues. (els.net)
  • BMPs transmit their signals from membrane to nucleus through distinct combinations of types I and II serine/threonine kinase receptors and their intracellular effectors the Smad proteins. (els.net)
  • Bone morphogenetic proteins (BMPs) are important pleiotropic cytokines controlling a wide variety of biological responses ranging from early development, skeletogenesis and homeostasis of several tissues to suppression of tumorigenesis. (els.net)
  • Those cytokines and growth factors considered to be of particular importance during bone development and growth include the IGFs, TGF a and b , bone morphogenetic proteins (BMPs), FGF, PDGF and epidermal growth factor (EGF). (unu.edu)
  • 1998), trigged by the presence bone morphogenetic proteins (BMPs). (scielo.br)
  • We have studied the roles of transforming growth factor (TGF)-beta and its related proteins (bone morphogenetic proteins, BMPs) on cancer microenvironment, by using molecular and cellular biological methods as well as recent genome biological techniques and biomaterials. (nii.ac.jp)
  • Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 are members of the TGF-beta gene family most closely related to the Drosophila Decapentaplegic and Xenopus Vg-1 genes. (biologists.org)
  • Importantly, bioinformatic analysis shows that genes regulated by KLF4 overlap significantly with those expressed in metastatic prostate cancer patients and in three individual cohorts with bone metastases, strengthening the clinical relevance of the findings in our xenograft model. (nature.com)
  • Association analysis of polymorphisms rs12997 in ACVR1 and rs1043784 in BMP6 genes involved in bone morphogenic protein signaling pathway in primary angle-closure and pseudoexfoliation glaucoma patients of Saudi origin. (nih.gov)
  • In the normal mouse embryo, Bmp4 is expressed in mesenchymal cells surrounding the Wolffian duct (WD) and ureter stalk, whereas bone morphogenetic protein (BMP) type I receptor genes are transcribed either ubiquitously ( Alk3 ) or exclusively in the WD and ureter epithelium ( Alk6 ). (jci.org)
  • Increasing research has demonstrated that expression of brain and muscle ARNT‑like 1 (BMAL1) and other circadian clock genes can be regulated by drugs and toxicants. (spandidos-publications.com)
  • Two of the 13 genes more highly expressed in BCC-derived stromal cells, GREM1 ( GREMLIN 1 ) and FST ( FOLLISTATIN ), both encode antagonists of the BMP pathway. (biology-online.org)
  • cDNAs dos genes bone morphogenetic protein-2 (BMP-2) e bone morphogenetic protein -4 (BMP-4) foram sintetizados a partir de RNA total extraído de tecidos ósseos de pacientes que apresentavam trauma facial (fraturas do maxilar entre o 7º e o 10º dia pós-trauma) e clonados num vetor para expressão em células mamíferas, sob controle do promotor de citomegalovírus (CMV). (scielo.br)
  • Bone morphogenetic protein type I receptors are single pass, type I transmembrane proteins. (wikipedia.org)
  • We have previously identified a series of type I serine/threonine kinase receptors, termed activin receptor-like kinase (ALK)-1 to -6. (elsevier.com)
  • In transfected COS cells, the binding of osteogenic protein (OP)-I and BMP-4 to certain ALKs was observed in the absence of type II receptors, and their binding was increased after co-transfection of a BMP type II receptor from Caenorhabditis elegans, DAF-4. (elsevier.com)
  • Characterization of receptors for osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7) in rat kidneys. (scienceexchange.com)
  • However, platelet-derived growth factor, transforming growth factor-beta, insulin-like growth factor, fibroblast growth factors, and other members of BMP family such as BMP-2 and cartilage-derived morphogenetic protein-1/growth and differentiation factor-5 (CDMP-1/GDF-5) failed to inhibit the binding of (125)I-labeled OP-1 to receptors, suggesting a high degree of specificity with which OP-1 bound to kidney receptors. (scienceexchange.com)
  • Scatchard analysis of quantitative binding data indicated that the OP-1 receptors of kidney contained a single class of high-affinity binding sites for OP-1 with an association constant (Ka) of 2.26 x 109 mol/L-1 and a binding capacity of 1.01 pmol of OP-1 per mg membrane protein. (scienceexchange.com)
  • CONCLUSIONS We demonstrated, to our knowledge for the first time, the presence of membrane-bound, specific, high-affinity OP-1 receptors in rat kidney tissues, which are likely to mediate OP-1 actions in the kidney. (scienceexchange.com)
  • 1995) "Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects", J. Cell. (nih.gov)
  • Inhibition of bone morphogenetic protein 6 receptors ameliorates Sjogren's syndrome in mice. (nih.gov)
  • Following secretion into the extracellular space, BMP dimers bind to BMP type II receptors, which then heterodimerize with type I receptors ( Figure 1A,B ). There are three type I receptors and three type II receptors ( Table 1 ) [ 4 ]. (portlandpress.com)
  • Interestingly, Ng1 protein inhibited the BMP7-induced alkaline phosphatase activity while it did not inhibit the BMP2-induced activity. (elsevier.com)
  • Formalin-fixed and paraffin embedded rabbit alveolar bone labeled with Anti-BMP7 Polyclonal Antibody, Unconjugated (ABIN678938) at 1:200 followed by conjugation to the secondary antibody and DAB staining. (antibodies-online.com)
  • One of these agents is bone morphogenetic protein-7 (BMP7), which has beneficial effects in multiple models of fibrotic disease. (frontiersin.org)
  • Here, we show that bone morphogenetic protein-4 (BMP4) blocks metastasis in animal models of breast cancer and predicts improved survival in patients. (aacrjournals.org)
  • Restored BMP4 expression or therapeutically administered BMP4 protein, blocked metastasis and increased survival by sensitizing cancer cells to anoikis, thereby reducing the number of circulating tumor cells. (aacrjournals.org)
  • Administration of recombinant BMP4 markedly reduced spontaneous metastasis to lung and bone. (aacrjournals.org)
  • This is not due to lack of precursor cells but to an inability to induce their commitment and differentiation through inactivation of canonical WNT signaling and allowing bone morphogenetic protein 4 (BMP4) to initiate commitment of precursor cells. (diabetesjournals.org)
  • The WNT-inducible secreted protein 2 (WISP2) links WNT and BMP4 signaling. (diabetesjournals.org)
  • Second, we used bone morphogenetic protein 4 ( BMP4 ) and lunatic fringe ( Fng ) as molecular markers to identify the origin of the sensory structures. (jneurosci.org)
  • One such candidate gene was bone morphogenetic protein 4 ( BMP4 ), a member of the transforming growth factor-β gene family. (jneurosci.org)
  • Bone morphogenetic protein 2 (BMP2) antagonizes Shh proliferative effect by promoting cell cycle exit and differentiation in CGNPs. (duke.edu)
  • Moreover, TIEG-1 synergizes with BMP2 activity to terminally differentiate CGNPs and independent differentiator signals such as dibutyryl cAMP and prevents apoptosis in TIEG-1 arrested cells. (duke.edu)
  • All together, these data strongly suggest that the BMP2 pathway triggers cell cycle exit and differentiation as two separated but coordinated processes, where TIEG-1 acts as a mediator of the cell cycle arrest. (duke.edu)
  • The expression of bone morphogenetic protein 2 (BMP2), RUNX family transcription factor 2 (RUNX2), alkaline phosphatase (ALP), osteocalcin (OC) and BMAL1 in BMSCs was evaluated by reverse transcription‑quantitative PCR and western blotting. (spandidos-publications.com)
  • There are limited studies on the factors that regulate the processing of TGF-β2 and extracellular matrix (ECM) proteins into their mature form. (arvojournals.org)
  • 8 These enzymes are known to change the physical properties and increase stiffness of tissues by cross-linking extracellular matrix (ECM) proteins (e.g., collagens and elastin) and inhibiting ECM turnover. (arvojournals.org)
  • We investigated whether the pro-fibrotic matricellular protein osteopontin (OPN) is associated with the enzymes involved in the extracellular synthesis of fibril-forming collagen type I (i.e. procollagen C-proteinase, PCP) and its cross-linking to form insoluble fibrils (i.e. lysyl oxidase, LOX) in heart failure (HF) of hypertensive origin. (nih.gov)
  • however, treatment of HDFs with KGHR-containing, TSP1-binding, triple-helical peptides disrupted the collagen-TSP1 association, perturbed the collagen extracellular matrix, and increased myofibroblastic differentiation in a manner that depended on TGF-β receptor 1. (sciencemag.org)
  • Mrowiec T, Melchar C, Górski A «HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium. (wikipedia.org)
  • Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain. (wikipedia.org)
  • EGF-like domains in extracellular matrix proteins : localized signals for growth and differentiation? (nii.ac.jp)
  • They belong to a class of receptor serine/threonine kinases that bind members of the TGF beta superfamily of ligands-the Bone morphogenetic proteins. (wikipedia.org)
  • Bone morphogenetic proteins and related members of the TGF-β (transforming growth factor-β) superfamily are involved in the development and repair of bone. (elsevier.com)
  • the closest members to dpp within the TGF-β superfamily are BMP-2 and BMP-4, two other bone morphogenetic proteins. (umn.edu)
  • BACKGROUND Osteogenic protein-1/bone morphogenetic protein-7 (OP-1/BMP-7), a member of the transforming growth factor-beta superfamily, has been shown to prevent kidney damage from ischemia/reperfusion injury in rats. (scienceexchange.com)
  • This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. (nih.gov)
  • All these proteins belong to the scavenger receptor cysteine-rich (SRCR) superfamily of proteins: a superfamily of secreted or membrane-bound proteins with SRCR domains that are highly conserved down to sponges, the most ancient metazoa. (mdpi.com)
  • 1990 ) Chromosomal localization of seven members of the murine TGF-superfamily suggests close linkage to several morphogenetic mutant loci. (biologists.org)
  • Growth differentiation factors (GDFs) are a subfamily of proteins belonging to the transforming growth factor beta superfamily that have functions predominantly in development. (wikipedia.org)
  • Wozney, J.M. (1992) "The bone morphogenetic protein family and osteogenesis", Mol. (nih.gov)
  • 1992 ) Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development. (biologists.org)
  • Osteogenic protein-1 (OP-1) is a member of the transforming growth factor-beta super family closely related to the bone morphogenetic proteins and also known as bone morphogenetic protein-7. (nih.gov)
  • Osteogenic protein-1 (also known as bone morphogenetic protein-7) is a member of the bone morphogenetic protein family. (elsevier.com)
  • We investigated the influence of recombinant osteogenic protein-1 (at doses of three, ten, thirty, or 100 nanograms per milliliter) on the synthesis and release of proteoglycans and the maintenance of a steady-state concentration of proteoglycans in explants of porcine articular cartilage that were maintained in chemically defined serum-free medium. (elsevier.com)
  • The size of the proteoglycan monomers and the composition of the glycosaminoglycan chains in the untreated articular cartilage were similar to those in the articular cartilage treated with osteogenic protein-1. (elsevier.com)
  • Our results demonstrated that osteogenic protein-1 stimulated the synthesis of proteoglycans and diminished the release of proteoglycans from explants of porcine articular cartilage. (elsevier.com)
  • The stimulation of proteoglycan synthesis by osteogenic protein-1. (elsevier.com)
  • bone morphogenetic protein-7) in explants of cartilage maintained in chemically defined serum-free medium implies that recombinant osteogenic protein-1 may play a role in the maintenance of a steady-state concentration of proteoglycans in articular cartilage, a desirable prerequisite for optimum repair of cartilage. (elsevier.com)
  • Osteogenic protein-1 can initiate the formation of cartilage from mesenchymal cells. (elsevier.com)
  • Once new cartilage has formed at the site of repair, osteogenic protein-1 also may maintain the synthesis of proteoglycans. (elsevier.com)
  • Recently, the first clinical reports on bone regeneration by two recombinant human bone morphogenetic proteins (rhBMPs), BMP-2 and BMP-7 (also named osteogenic protein-1, OP-1) have been published (1-4). (mendeley.com)
  • KLF4 re-expression in established KLF4 null bone tumors inhibits their osteolytic effects, preventing bone fractures and inducing an osteogenic response with new bone formation. (nature.com)
  • However, the mechanism underlying the association between icariin and BMAL1 in osteogenic differentiation of bone marrow‑derived mesenchymal stem cells (BMSCs) remains unclear. (spandidos-publications.com)
  • The principal mechanism involves interruption of osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) ( 4 ). (spandidos-publications.com)
  • Publications] Mizuno.M..: 'An Osteonectin-Like Protein in the Matrix of Cultured Osteogenic Cell-Line MC3T3-E1' Calcified Tissue International. (nii.ac.jp)
  • In addition to their direct effects on osteogenic cells that will be discussed in a later paper, systemic agents may have important interactions with local factors in bone and cartilage. (unu.edu)
  • With the increase of the knowledge of the genetic osteogenic factors and genetic engineering, genetic therapy is becoming a viable alternative to obtain a satisfactory result in bone regeneration. (scielo.br)
  • The present invention relates to a novel family of purified proteins designated BMP-2 (wherein BMP is bone morphogenic protein) proteins and processes for obtaining them. (google.com)
  • Aim: To determine the potential of recombinant human bone morphogenetic protein-2 (rhBMP-2) soak-loaded on to an absorbable collagen sponge (ACS) to induce local bone formation compared with the clinical reference demineralized bone matrix (DBM) and to investigate potential additive/synergistic effects of exogenous parathyroid hormone (PTH). (elsevier.com)
  • Collectins are oligomeric proteins composed of C type lectin domains connected to collagen regions ( 1 ). (pnas.org)
  • The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects. (weltbild.de)
  • found that thrombospondin-1 (TSP1) bound to and inhibited the processing of the precursor form of the collagen cross-linking enzyme lysyl oxidase. (sciencemag.org)
  • Thrombospondin-1 (TSP1) plays an indirect role in collagen homeostasis through interactions with matrix metalloproteinases and transforming growth factor-β1 (TGF-β1). (sciencemag.org)
  • Connective Tissue Growth Factor and IGF-1 are Produced by Human Renal Fibroblasts and Cooperate in the Induction of Collagen Production by High Glucose," Diabetes (2003) 52:2975-2983. (freepatentsonline.com)
  • If type I collagen was dried and bone marrow cells were cultured on membrane-type collagen, collagen did not show inductive activity against bone marrow cells. (nii.ac.jp)
  • 5) These results indicate that features of collagen is crucial for the inductive activity against bone marrow cells. (nii.ac.jp)
  • However, the involvement of other signaling systems, including the bone morphogenetic protein (BMP) pathway, in the control of hair pigmentation remains to be elucidated. (elsevier.com)
  • After binding to microbial surfaces, MBL activates the complement system through a complement activation pathway, the MBL pathway, by using two recently identified serine proteases, MASP-1 and MASP-2, to activate C4 and C2 ( 2 ). (pnas.org)
  • A cell signal pathway involving laminin-5, alpha3beta1 integrin, and mitogen-activated protein kinase can regulate epithelial cell proliferation. (wikipedia.org)
  • It induces bone and cartilage development. (wikipedia.org)
  • PTH 1-34 induces bone morphogenetic protein (BMP) gene transcription. (sigmaaldrich.com)
  • Genetic and molecular studies suggest that activin receptor-like kinase 1 (ALK1), a transforming growth factor β (TGF-β) type I receptor, and endoglin, a TGF-β co-receptor, play an essential role in vascular development and pathological angiogenesis. (jpt.com)
  • Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. (uniprot.org)
  • Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase. (abcam.com)
  • Upon binding to the LIF receptor, LIF activates three major intracellular signalling pathways: the JAK (Janus kinase)/STAT3 (signal transducer and activator of transcription 3), PI3K (phosphoinositide 3-kinase)/AKT and SHP2 [SH2 (Src homology 2) domain-containing tyrosine phosphatase 2]/MAPK (mitogen-activated protein kinase) pathways. (biochemj.org)
  • BMP-14 is expressed in long bones during embryonic development and postnatally in articular cartilage. (creative-bioarray.com)
  • In the present study binding between the two proteins was further determined in human embryonic cell 293 (HEK293), a mammalian expression system. (bvsalud.org)
  • GDF2 (also known as BMP9) induces and maintains the response embryonic basal forebrain cholinergic neurons (BFCN) have to a neurotransmitter called acetylcholine, and regulates iron metabolism by increasing levels of a protein called hepcidin. (wikipedia.org)
  • Expression of GDF3 occurs in ossifying bone during embryonic development and in the thymus, spleen, bone marrow brain, and adipose tissue of adults. (wikipedia.org)
  • GDF6 interacts with bone morphogenetic proteins to regulate ectoderm patterning, and controls eye development. (wikipedia.org)
  • In recent years it has been demonstrated that a large number of growth factors and cytokines regulate the proliferation and differentiation of bone and cartilage cells in vitro and in vivo (Table 2). (unu.edu)
  • Moreover, in situ hybridization and immunostaining methods have shown localization of mRNA transcripts and the protein for BMP receptor type II in the cortex and medulla in similar areas as (125)I-labeled OP-1. (scienceexchange.com)
  • 1991 Nov 1;67(3):469-481. (umn.edu)
  • 1988). However, in the rat, IGF-I is considered to be more important than IGF-II in regulating bone cell metabolism (Mohan & Baylink, 1991). (unu.edu)
  • Pools of overlapping peptides from antigenic proteins for T-cell stimulation, T-cell expansion in T-cell assays such as ELISPOT, ICS or Flow Cytometry, e.g. for immune monitoring. (jpt.com)
  • 614856 ]. An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility, low bone mass, and recurrent fractures. (proteopedia.org)
  • The expression of bone morphogenetic proteins (BMP) in primary osseous tumors (n=15) with a potential of osteogenesis and/or chondrogenesis was re-evaluated by using a recently characterized monoclonal antibody raised by using rhBMP-2 as an immunogen in a streptavidin-biotin complex immunoperoxidase method. (nii.ac.jp)
  • Publications] Nagai.N: 'Histological studies of heteotopic osteogenesis induced by bone morphogenetic protein binding apatite' Apatite. (nii.ac.jp)
  • Publications] Nagai, Y.Inoue, N.Mizuno, M.and Kuboki, Y.: 'Histological studies of heterotopic osteogenesis induced by bone morphogenetic protein binding apatite' Apatite. (nii.ac.jp)
  • These proteins may be used to induce bone and/or cartilage formation and in wound healing and tissue repair. (google.com)
  • BMP compositions including the human factor and bovine factor thereof, the process of isolating BMP compositions and factors, and the use of such factors and compositions to induce bone formation in animals. (google.ca)
  • Human BMP-2 is characterized by the ability to induce bone formation. (google.com)
  • The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. (nih.gov)
  • 1995) "Cloning and characterization of a human type II receptor for bone morphogenetic proteins", Proc. (nih.gov)
  • Three collectins are known in humans: mannan-binding lectin (MBL), a serum protein, and the lung surfactant proteins A and D (SP-A and SP-D), which are produced by epithelial cells mainly in the lung. (pnas.org)
  • La Laminina subunitat alfa 3 és una proteïna que en els humans és codificada pel gen LAMA3 . (wikipedia.org)
  • In vivo and in vitro evidence suggests that the cellular targets for OP-1 are convoluted tubule epithelium, glomeruli, and collecting ducts. (scienceexchange.com)
  • We analyzed expression of GREMLIN 1 in vivo in human tissue by quantitative RT-PCR analysis of independent samples of whole tissue from eight matched BCC and adjacent nontumor skin samples. (biology-online.org)
  • The oral tissues, a part of the mucosal immune system, are constantly covered by saliva, which harbors a similar set of antimicrobial proteins as other mucosal fluids [ 2 ]. (mdpi.com)
  • Losses of bone tissues occur due to several factors, most importantly due to accidents. (scielo.br)
  • 10. A composition of claim 9 further comprising a matrix for supporting said composition and providing a surface for bone and/or cartilage growth. (google.com)
  • Work with BMP material isolated from rabbit dentin matrix protein fraction, using polyacrylamide gel electrophoresis (PAGE) has been assigned a molecular weight of about 23,000. (google.ca)
  • In addition to having effects on the growth plate chondrocytes, locally synthesised and circulating IGFs retained in bone matrix are important in the regulation of bone remodelling. (unu.edu)
  • We also demonstrate that TIEG-1 ectopic expression in CGNPs induces cell cycle arrest that can lead to apoptosis but fails to promote differentiation. (duke.edu)
  • Bone regeneration in surgically created defects filled with autogenous bone: an epifluorescence microscopy analysis in rats," Journal of Applied Oral Science , vol. 18, no. 4, pp. 346-353, 2010. (hindawi.com)
  • BMP-2 proteins are further characterized by the ability to induce the formation of cartilage and/or bone. (google.com)
  • Hair pigmentation is controlled by tightly coordinated programs of melanin synthesis and involves signaling through the melanocortin type 1 receptor (MC-1R) that regulates the switch between pheomelanogenesis and eumelanogenesis. (elsevier.com)
  • Tissue localization, in situ hybridization, and immunostaining with a specific receptor antibody were performed to identify OP-1 cellular targets. (scienceexchange.com)
  • Further analysis by Western blotting indicated that an antibody raised against BMP type II receptor effectively recognized the 100 kD OP-1 binding component of kidney plasma membranes. (scienceexchange.com)
  • The anti-hALK1 antibody interfered with bone morphogenetic protein 9 (BMP9)-induced signaling in endothelial cells. (jpt.com)
  • In co-immunoprecipitation experiments, HEK293 cells expressing alpha(1A)-AR or/and segment of BMP-1 were lysed and incubated with anti-FLAG M2 antibody, then the immunoprecipitation pellet was immunoblotted with either the HRP conjugated anti-FLAG antibody or the anti-HA antibody, which recognizes the HA-tagged segment of BMP-1. (bvsalud.org)
  • 1989) "Purification and partial amino acid sequence of osteogenin, a protein initiating bone differentiation", J. Biol. (nih.gov)
  • The molecular events involved in OP-1 action on kidney are not yet understood. (scienceexchange.com)
  • Also, isolated plasma membranes from kidney cortex and medulla regions were analyzed to identify and characterize receptor structural components that recognize OP-1. (scienceexchange.com)
  • RESULTS At 10 and 180 minutes following injection, the relative uptake of (125)I-labeled OP-1 was consistently higher in kidney cortex than in medulla region. (scienceexchange.com)
  • Upon autoradiography, kidney tissue sections revealed that OP-1 bound to the convoluted tubule epithelium, glomeruli, and collecting ducts. (scienceexchange.com)
  • Bulk membranes (enriched with plasma membranes) isolated from the cortex and medulla regions of kidney each bound specifically to (125)I-OP-1, and the binding of (125)I-labeled OP-1 was inhibited by unlabeled OP-1 in a dose-dependent manner. (scienceexchange.com)
  • The major OP-1-binding component of the kidney appears to be a long form of BMP type II receptor with a Mr of 100 kD. (scienceexchange.com)
  • OP-1 does not share receptor binding properties with other growth factors, including BMP-2 and CDMP-1, suggesting that its mode of action in kidney appears to be specific. (scienceexchange.com)
  • Parathyroid hormone (PTH) is a parathyroid-secreted polypeptide hormone that increases the level of calcium in blood by enhancing calcium mobilization from bone, increasing the calcium:phosphate ratio in the kidney and promoting the absorption of calcium by the intestines. (sigmaaldrich.com)
  • early endothelial outgrowth cells (eEOCs), a major subpopulation of so-called endothelial progenitor cells (EPCs) ( 1 , 6 , 19 , 33 ), have been shown to protect mice reliably from acute ischemic kidney injury (AKI) ( 19 , 20 , 23 ). (physiology.org)
  • 2. The process of claim 1 wherein said BMP composition activates DNA sequences that code for bone morphogenesis. (google.ca)
  • La evolución del conocimiento relacionado a la Biología Molecular ha sido aplicado en diferentes áreas de la Biología Clínica, entre ellas la Odontología , permitiendo el uso de esos nuevos adelantos en el tratamiento de agresiones al órgano pulpar. (bvsalud.org)
  • Brain and muscle ARNT-like 1 (BMAL1) is the most important component of the molecular biological clock, expression of which has been found to have 24-h periodicity in bone. (spandidos-publications.com)
  • Understanding the molecular role of cofilin-2, an actin-binding protein, in various organs including muscle, lungs and heart. (childrenshospital.org)
  • In contrast, Vgr-1 transcripts are found along the anteroposterior axis of the CNS, in cells immediately adjacent to the floor plate and in the roof plate extending to the forebrain. (biologists.org)
  • Our results suggest that pluripotent human EC cells differentiate in response to OP-1 and that this factor can modulate the differentiation induced by retinoic acid. (nih.gov)
  • In this study, we found that Ng1 was expressed in the primordial cells of the skeleton and investigated whether Ng1 protein inhibited the BMP action to induce osteoblastic differentiation in C2C12 myoblasts. (elsevier.com)
  • Here, we show that the anti-tumorigenic effect of KLF4 extends to PC3 human prostate cancer cells growing in the bone. (nature.com)
  • Furthermore, KLF4 null cells proliferate rapidly, forming large, invasive, and osteolytic tumors when injected into mouse femurs, whereas KLF4 re-expression immediately after their intra-femoral inoculation blocks tumor development and preserves a normal bone architecture. (nature.com)
  • Human TM cells synthesize and secrete enzymatically active lysyl oxidase (LOX) and lysyl oxidase like (LOXL) proteins. (arvojournals.org)
  • Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc. (duke.edu)
  • Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation. (rcsi.com)
  • To examine HNF1A-MODY-induced defects in gene expression, we performed a microarray analysis of the transcriptome of rat INS-1 cells inducibly expressing the common hot spot HNF1A frameshift mutation, Pro291fsinsC-HNF1A. (rcsi.com)
  • Interestingly, treatment of naïve INS-1 cells or murine organotypic islet cultures with recombinant human BMP-3 potently increased their insulin levels and restored the decrease in SMAD2 phosphorylation and insulin gene expression induced by the HNF1A frameshift mutation. (rcsi.com)
  • Our study suggests a critical link between HNF1A-MODY-induced alterations in Bmp-3 expression and insulin gene levels in INS-1 cells and indicates that the reduced expression of growth factors involved in tissue differentiation may play an important role in the pathophysiology of HNF1A-MODY. (rcsi.com)
  • alpha(1A)-AR and the segment of BMP-1 could be detected in the lysis of transfected cells . (bvsalud.org)
  • In conclusion, the results indicate that alpha(1A)-AR and the segment of BMP-1 are present in the same complex in HEK293 cells . (bvsalud.org)
  • Bone morphogenetic protein 6 affects cell-cell communication by altering the expression of Connexin43 in human granulosa-lutein cells. (nih.gov)
  • Intestinal epithelial cells renewal is ensured by intestinal epithelial stem cells (IESCs) located in the crypts and identified by expression of Lgr5 ( 1 ). (pnas.org)
  • BMP receptor 1α activation limits the TGF-β-mediated differentiation of CD4 + T cells that produce the cytokine IL-17. (sciencemag.org)
  • 1) Bone marrow cells contained stem cells that possess the potency of multi-differentiation. (nii.ac.jp)
  • 3) These findings indicated that the process of mineralization in calcified nodules is similar to that of body, and the calcified nodules formed by bone marrow cells are same with bone. (nii.ac.jp)
  • Publications] Zhou H-Y: 'Effect of a bone lysine-rich 18 KDa protein on osteoblaet-like MC3T3-E1 Cells' Biochem.Biophys.Res.Commun.186. (nii.ac.jp)
  • To better characterize the stromal cell population that expressed GREMLIN 1 in BCC tumors, we analyzed adjacent serial sections of tumor by ISH for GREMLIN 1 and IHC for various cell lineage markers: vimentin (characteristic of mesenchymal cells), CD45 (hematopoietic lineage), CD31 (endothelial cells), desmin (smooth muscle cells), cytokeratins (epithelial cells), and glial fibrillary acid protein (astrocytes and Schwann cells). (biology-online.org)
  • GREMLIN 1- expressing cells were also strongly positive for vimentin, mostly or entirely negative for CD45 and desmin, and completely negative for CD31, keratins, and glial acid fibrillary protein (GFAP) ( Fig. 2 G-N ). (biology-online.org)
  • A Functional Response to gremlin 1 in Cultured Human Skin Epithelial Cells. (biology-online.org)
  • To directly examine the effects of gremlin 1 on BCC tumor cells, cells isolated from fresh BCC tumors were cultured in the presence of recombinant human BMP 4, recombinant mouse gremlin 1, or both, and allowed to expand for 7 days. (biology-online.org)
  • Effects of Gekko sulfated polysaccharide-protein complex on human hepatoma SMMC-7721 cells: Inhibition of proliferation and migration," Journal of Ethnopharmacology , vol. 127, no. 3, pp. 702-708, 2010. (hindawi.com)
  • There is also increasing evidence that abnormal production of cytokines in diseases such as rheumatoid arthritis, osteoarthritis and osteoporosis may result in inappropriate responses by bone and cartilage cells. (unu.edu)
  • Many of the cell types present in the microenvironment of growing bone contribute to the local synthesis of cytokines and growth factors including the resident endothelial cells, marrow stromal cells, osteoblasts, periosteal cells and chondrocytes. (unu.edu)
  • In fact, several lines of evidence point to there being a close relationship between bone cells and cells of the immune system (Skjodt & Russell, 1993). (unu.edu)
  • Bone Cells Differentiation: How CFTR Mutations May Rule the Game of Stem Cells Commitment? (frontiersin.org)
  • The defect of CFTR chloride channel or the loss of CFTR's ability to interact with other proteins affect several signaling pathways involved in stem cell differentiation and the commitment of these cells toward bone lineages. (frontiersin.org)
  • In this review, we summarize the existing literature on the role of CFTR mutations on the commitment of induced pluripotent stem cells to bone cells. (frontiersin.org)
  • His lab pioneered research on the effect of bone morphogenetic proteins and LMP-1 on disc cells. (spine.org)
  • This molecule, unlike bone morphogenetic protein's, has very little bone stimulation but has cartilage stimulation effect on disc cells. (spine.org)
  • Members of this family include TGF-βs 1-5, bone morphogenetic proteins, growth/differentiation factors, and inhibins/activins. (aacrjournals.org)
  • Taken together, these data suggests that BMP signaling controls the expression of Agouti protein in the hair follicle and provide evidence for interaction between BMP and MC-1R signaling pathways to modulate the balance between pheomelanogenesis and eumelanogenesis during hair growth. (elsevier.com)
  • GDF15 (also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB) has a role in regulating inflammatory and apoptotic pathways during tissue injury and certain disease processes. (wikipedia.org)
  • Here, we use in situ hybridization to localize BMP-4 and Vgr-1 transcripts during murine development. (biologists.org)
  • There are seven isoforms of the protein created by alternate splicing. (wikipedia.org)
  • Human keratinocytes express three TGF-β isoforms (1 , 2 , 3) , which have multiple effects on gene expression and cellular differentiation. (aacrjournals.org)
  • Twenty-four hours after induction of the mutant HNF1A protein, we identified a prominent down-regulation of the bone morphogenetic protein 3 gene (Bmp-3) mRNA expression. (rcsi.com)
  • In contrast, inducible expression of wild-type HNF1A led to a time-dependent increase in Bmp-3 mRNA and protein levels. (rcsi.com)
  • The Drosophila homolog encoded by the decapentaplegic locus is involved in dorsal-ventral pattern formation during embryogenesis, whereas the expression of several bone morphogenetic proteins including OP-1 is developmentally regulated in mammalian embryos. (nih.gov)