Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Bone Resorption: Bone loss due to osteoclastic activity.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Diphosphonates: Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Bone Diseases: Diseases of BONES.Bone Development: The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Osteolysis: Dissolution of bone that particularly involves the removal or loss of calcium.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Breast Neoplasms: Tumors or cancer of the human BREAST.Osteoclasts: A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.Lung Neoplasms: Tumors or cancer of the LUNG.Bone Regeneration: Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.Bone Matrix: Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.Cell Line, Tumor: A cell line derived from cultured tumor cells.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Bone Density Conservation Agents: Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.Liver Neoplasms: Tumors or cancer of the LIVER.Bone Transplantation: The grafting of bone from a donor site to a recipient site.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Fractures, Bone: Breaks in bones.Osteoblasts: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Strontium Radioisotopes: Unstable isotopes of strontium that decay or disintegrate spontaneously emitting radiation. Sr 80-83, 85, and 89-95 are radioactive strontium isotopes.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Technetium Tc 99m Medronate: A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.Alkaline Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.RANK Ligand: A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.Bone Substitutes: Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Bone Morphogenetic Proteins: Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Bone Diseases, MetabolicSamarium: Samarium. An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Spinal NeoplasmsParathyroid Hormone-Related Protein: A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.Imidazoles: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Radium: Radium. A radioactive element of the alkaline earth series of metals. It has the atomic symbol Ra, atomic number 88, and atomic weight 226. Radium is the product of the disintegration of uranium and is present in pitchblende and all ores containing uranium. It is used clinically as a source of beta and gamma-rays in radiotherapy, particularly BRACHYTHERAPY.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Kidney Neoplasms: Tumors or cancers of the KIDNEY.Bone Marrow Neoplasms: Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.Osteogenesis: The process of bone formation. Histogenesis of bone including ossification.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Bone Morphogenetic Protein 2: A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Osteoprotegerin: A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.Palliative Care: Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)Temporal Bone: Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).Osteocalcin: Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.Femur: The longest and largest bone of the skeleton, it is situated between the hip and the knee.Skin Neoplasms: Tumors or cancer of the SKIN.Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Bone Cancer: for bone metastases located in the spine, pelvis and long bones. Breast Cancer: for small tumours. Prostate Cancer ... Pancreatic cancer: inoperable advanced neoplasms. 1930 - First therapeutic embolization procedure (of a carotid-cavernous ... MR imaging-guided focused ultrasound for treatment of bone metastasis. Radiographics. 2013 Oct;33(6):1555-68. doi:10.1148/rg. ... 1990s - Treatment of bone and kidney tumors by embolization. 1990s - RFA for soft tissue tumors, i.e., bone, breast, kidney, ...
... patients with Hürthle cell carcinoma have distant metastases in the lungs or surrounding bones. Hürthle cell neoplasms are ... Some scientists have identified these mutations as deletions in the mitochondrial DNA of Hürthle cells found in neoplasms and ... Erickson, Lori A. "Hurthle Cell Thyroid Neoplasms." Atlas of Endocrine Pathology. Springer New York, 2014. 63-66. EndocrineWeb ...
... and maybe the number of metastases. Overall survival prognosis is about 30%. Deaths due to malignant neoplasms of the bones and ... a smaller number of metastases, and their resectability. It is better to have fewer metastases than longer time to metastases. ... Rarely, osteosarcoma may arise from soft tissues (extraskeletal osteosarcoma). Metastasis of tumors involving the limb bones is ... The tumor causes a great deal of pain, and can even lead to fracture of the affected bone. As with human osteosarcoma, bone ...
It most commonly manifests itself in the femur and proximal tibia as a bone sarcoma, and is usually found in older individuals ... Hemangiopericytoma is a rare vascular neoplasm, or abnormal growth, that may either be benign or malignant. In its malignant ... form, metastasis to the lungs, liver, brain, and extremities may occur. ... Treatment may involve surgical removal and radiation therapy, depending on the level of bone penetration and stage in the ...
The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... but an infiltrating neoplasm makes it difficult to say where the tumor ends and the healthy tissue starts. metastasis (spread ... bone metastasis of glioblastoma multiforme.) Primary brain tumors generally are invasive (i.e. they will expand spatially and ... "Bone metastasis of glioblastoma multiforme confirmed by fine needle biopsy". Acta Neurochirurgica. 141 (5): 551-52. doi:10.1007 ...
The most common malignancy found in bone is metastatic carcinoma. Skin lesion Metastasis James, William; Berger, Timothy; ... dissemination to the skin may occur with any malignant neoplasm, and these infiltrates may result from direct invasion of the ...
The most common site of TCC metastasis outside the pelvis is bone(35%); of these bone metastases, 40 percent are in the spine. ... papillary neoplasm of low malignant potential [PNLMP], low grade, and high grade papillary carcinoma). Histopathology of ... Punyavoravut V, Nelson SD (August 1999). "Diffuse bony metastasis from transitional cell carcinoma of urinary bladder: a case ...
Occasionally, a bone metastasis of a GCCL could potentially be mistaken for a primary giant-cell tumor of bone - interestingly ... Spivach A, Borea B, Bertoli G, Daris G (July 1976). "[Primary lung neoplasm of rare incidence: giant cell carcinoma]". Minerva ... Within the small bowel, the jejunum seems to be a preferred site for metastasis of GCCL. GCCL also often metastasizes to bone, ... Willebrand H, Wernitsch W, Elmohamed A (September 1970). "[Pulmonary metastases of a giant-cell carcinoma in the bone-benign or ...
The commonest sites for distant metastases are the lung, bone, and abdominal viscera. Rare sites of metastasis like to parotid ... They account for less than 1% of all breast neoplasms. Phyllodes tumors are a fibroepithelial tumor composed of an epithelial ... The risk of developing local recurrence or metastases is related to the histologic grade, according to the above-named features ... Approximately 10% of patients with phyllodes tumours develop distant metastases and this can go up to 20% in patients with ...
... this is thought to be the route of bone metastasis of prostate cancer. It is sometimes known as "Santorini's plexus," named for ... Prostate Neoplasms". Pathology study images. University of Virginia School of Medicine. Archived from the original on 2011-04- ...
... or to relieve pain from bone metastasis. Radioactive contamination Chapter 20 in: Mitchell, Richard Sheppard; Kumar, Vinay; ... Thyroid neoplasm is a neoplasm or tumor of the thyroid. It can be a benign tumor such as thyroid adenoma, or it can be a ... Thyroid neoplasm might be classified as benign or malignant. Thyroid adenoma is a benign neoplasm of the thyroid. Thyroid ... The first step in diagnosing a thyroid neoplasm is a physical exam of the neck area. If any abnormalities exist, a doctor needs ...
... parotid gland neoplasms, or metastases of other tumors. Other causes like viral, bacterial or fungal infections like chicken ... More commonly longitudinal fracture of petrous bone and fracture of temporal bone can cause facial nerve compression. Use of ... foassa technique is most commonly used for the decompression of the facial nerve in Bell's palsy and longitudinal temporal bone ... forceps during the delivery can cause trauma to facial nerve.Compression of the diploic bone of the infant's rudimentary ...
Bone metastases. The bones are a very common site of metastatic disease from breast cancer, and bone metastases can cause ... breast cancer metastasis neoplasm chemotherapy Mouse models of breast cancer metastasis Phyllodes tumour "Secondary (metastatic ... of all patients living with advanced breast cancer have bone metastases.[citation needed] Very often bone metastases can be ... In breast cancer, spinal-cord compression occurs when a bone metastasis or spinal metastasis begins to push on the spinal cord ...
For certain types of cancer, such as early head and neck cancer, it may be used alone.[155] For painful bone metastasis, it has ... They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... Metastasis. Main article: Metastasis. Metastasis is the spread of cancer to other locations in the body. The dispersed tumors ... Metastasis. Main article: Metastasis. Cancer can spread from its original site by local spread, lymphatic spread to regional ...
Lung cancer is an extremely heterogeneous family of malignant neoplasms, with well over 50 different histological variants ... and metastasis characteristic of malignant tumors. The increased differential activity usually results in fewer troubling side ... effects for cancer patients, particularly less nausea, vomiting, and death of cells in the bone marrow and gastrointestinal ...
June 2006). "Brown tumors mimicking bone metastases". J Natl Med Assoc. 98 (6): 950-3. PMC 2569361 . PMID 16775919. Aoki, J.; ... It is not a true neoplasm, as the term "tumor" suggests; however, it may mimic a true neoplasm. It most commonly affects the ... The osteoclasts consume the trabecular bone that osteoblasts lay down and this front of reparative bone deposition followed by ... Hemosiderin deposition is not a distinctive feature of brown tumors; it may also be seen in giant cell tumors of the bone. ...
... and bone marrow). This latter form of HS is most like malignant histiocytosis (MH). MH is an aggressive, histiocytic neoplasm ... HS and MH are capable of widespread metastasis, hence in time the 2 syndromes merge clinically and it is not always possible to ... Disseminated HS (including MH) is not readily treated surgically, since even in the splenic form, early metastasis to the liver ... The liver is usually bile stained (jaundice) and disruption of the lobular pattern due to metastasis is observed - marked liver ...
The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... "Bone metastasis of glioblastoma multiforme confirmed by fine needle biopsy". Acta Neurochirurgica. 141 (5): 551-52. doi:10.1007 ... Brain metastasis in the right cerebral hemisphere from lung cancer, shown on magnetic resonance imaging. ... Secondary, or metastatic, brain tumors are more common than primary brain tumors,[2] with about half of metastases coming from ...
The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... "Bone metastasis of glioblastoma multiforme confirmed by fine needle biopsy". Acta Neurochirurgica. 141 (5): 551-52. doi:10.1007 ... Brain metastasis in the right cerebral hemisphere from lung cancer, shown on magnetic resonance imaging. ... "CNS and Miscellaneous Intracranial and Intraspinal Neoplasms" (PDF). SEER Pediatric Monograph. National Cancer Institute. pp. ...
Unlike meoblastic nephorma, clear cell sarcoma of the kidney presents with metastasis, particularly to bone, in 5-6% of cases; ... of all childhood renal neoplasms. This neoplasm is generally non-aggressive and amenable to surgical removal. However, a ... primarily in the local area of surgery rare cases of relapse due to lung or bone metastasis.. About 60% of these recurrent ... It shows a mixture of the classic and cellular types in different areas of the neoplasm. A study conducted in 1998 found that ...
... this modulation is a mechanism of prostate cancer metastases facilitating their growth and survival in the reactive bone stroma ... TGF beta can act as a tumor suppressor in the premalignant stage of the benign neoplasm by inhibiting its growth and inducing ... It has been shown that endoglin expression and TGF-beta secretion are attenuated in bone marrow stromal cells when they are ... It has a crucial role in angiogenesis, therefore, making it an important protein for tumor growth, survival and metastasis of ...
It may prompt a bone scan to confirm or exclude spinal metastasis. Rapid identification and intervention of malignant spinal ... Spinal tumors are neoplasms located in the spinal cord. Extradural tumors are more common than intradural neoplasms. Depending ... MRI and bone scanning are used for diagnostic purposes. This assesses not only the location of the tumor(s) but also their ... "Vertebral Metastases with High Risk of Symptomatic Malignant Spinal Cord Compression". Japanese Journal of Clinical Oncology. ...
... has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of ... Plicamycin is currently used in multiple areas of research, including cancer cell apoptosis and as a metastasis inhibitor. One ... Brown, John H.; Kennedy, B. J. (1965). "Mithramycin in the Treatment of Disseminated Testicular Neoplasms". New England Journal ... Lin, Ruo-Kai; Hsu, Chun-Hua; Wang, Yi-Ching (2007). "Mithramycin a inhibits DNA methyltransferase and metastasis potential of ...
... or metastases of other tumours. Often, since facial neoplasms have such an intimate relationship with the facial nerve, ... Inflammation from the middle ear can spread to the canalis facialis of the temporal bone - through this canal travels the ... While this will inevitably lead to heightened paralysis, safe removal of a malignant neoplasm is worth the often treatable ... Physical trauma, especially fractures of the temporal bone, may also cause acute facial nerve paralysis. Understandably, the ...
These cells are then followed in the blood stream, lungs, bone marrow and liver to look for the favorable site of metastasis. ... also confirms the genetic heterogeneity between the primary neoplasm of breast cancer patients and their respective metastases ... Not only in blood but cells can be detected in bone marrow e.g. cytokeratin-positive cells in the bone marrow of MMTV-pyMT and ... Metastasis is a process of migration of tumour cells from the primary cancer site to a distant location where the cancer cells ...
An enchondroma is a cartilage cyst found in the bone marrow. Typically, enchondroma is discovered on an X-ray scan. Enchondromas have a characteristic appearance on Magnetic Resonance Imaging (MRI) as well. They have also been reported to cause increased uptake on PET examination. Enchondroma is a type of benign bone tumor that originates from cartilage. The exact etiology of it is not known. An enchondroma most often affects the cartilage that lines the inside of the bones. The bones most often involved with this benign tumor are the miniature long bones of the hands and feet. It may, however, also involve other bones such as the femur, humerus, or tibia. While it may affect an individual at any age, it is most common in adulthood. The occurrence between males and females is equal. It is not very likely ...
An osteosarcoma (OS) or osteogenic sarcoma (OGS) is a cancerous tumor in a bone. Specifically, it is an aggressive malignant neoplasm that arises from primitive transformed cells of mesenchymal origin (and thus a sarcoma) and that exhibits osteoblastic differentiation and produces malignant osteoid. Osteosarcoma is the most common histological form of primary bone cancer. It is most prevalent in teenagers and young adults. Many patients first complain of pain that may be worse at night, may be intermittent and of varying intensity and may have been occurring for some time. Teenagers who are active in sports often complain of pain in the lower femur, or immediately below the knee. If the tumor is large, it can present as overt localised swelling. Sometimes a sudden fracture is the first symptom, because affected bone is not as strong as normal bone and may fracture abnormally ...
... (commonly known as Paget's disease or historically, osteitis deformans) is a condition involving cellular remodeling and deformity of one or more bones. The affected bones show signs of dysregulated bone remodeling at the microscopic level, specifically excessive bone breakdown and subsequent disorganized new bone formation. These structural changes cause the bone to weaken, which may result in deformity, pain, fracture, or arthritis of associated joints. The exact cause is unknown, although leading theories indicate both genetic and acquired factors (see causes). Paget's disease may affect any one or multiple bones of the body (most commonly pelvis, femur, and lumbar vertebrae, and skull), but never the entire skeleton, and does not spread from ...
Saos-2 ("Sarcoma osteogenic") is a cell line derived from the primary osteosarcoma of an 11-year-old Caucasian girl in 1973 by Fogh et al. In 1987 Rodan et al. determined that Saos-2 cells "possess several osteoblastic features and could be useful as a permanent line of human osteoblast-like cells and as a source of bone-related molecules." Besides their worldwide availability, some of the advantages for using Saos-2 cell line are that they have well-documented characterization data, the possibility to obtain large amounts of cells in short time, and the fact that Saos-2 cells can be fully differentiated in a manner that the osteoblastic cells naturally do. The latter point is described particularly as "the ability of Saos-2 cells to deposit a mineralization-competent extracellular matrix", which makes these cells a valuable model for studying events associated with the late osteoblastic differentiation stage in human cells. Fogh J, Fogh JM, Orfeo T (1977). "One hundred and ...
Mouse and other animal models are being heavily used to determine the neuron tissue densities in bone[5] and mechanisms for maintenance of bone pain.[1] This information is pertinent to determining the biological and physiological components of pain in the bone. By creating a detailed map relating the types of nerves going through the different sections of bone, it is possible to pin-point locations in the bone that are at a higher risk of being susceptible to bone pain.[citation needed]. Treatments focusing on biological components such as cannabinoid receptors are being tested for effectiveness. Through testing in mouse models, it has been shown that activation of the CB-1 receptor helps reduce reactions associated with acute pain, indicating that it alleviates bone pain. ...
... (also known medically by several other names) is pain coming from a bone. It occurs as a result of a wide range of diseases and/or physical conditions and may severely impair the quality of life for patients who suffer from it. Bone pain belongs to the class of deep somatic pain, often experienced as a dull pain that cannot be localized accurately by the patient. This is in contrast with the pain which is mediated by superficial receptors in, e.g., the skin. Bone pain can have several possible causes ranging from extensive physical stress to serious diseases such as cancer. For many years it has been known that bones are innervated with sensory neurons. Yet their exact anatomy remained obscure due to the contrasting physical properties of bone and neural tissue. More recently, it is becoming clear what types of nerves innervated which ...
இப்பக்கத்தைக் கடைசியாக 5 திசம்பர் 2013, 09:18 மணிக்குத் திருத்தினோம் ...
神經母細胞瘤(Neuroblastoma)是一種在特定神經組織中形成的癌症。它最常從一側腎上腺開始,但也可以在頸部、胸部、腹部或脊髓中發展。[1]症狀包括骨痛(英语:bone pain)、腹部、頸部或胸部腫塊,或皮膚下無痛的藍色腫塊[1]。 神經母細胞瘤可能是由於基因突變所造成的[1]。尚未發現與環境因素的相關性[2]。根據其組織病理切片進行診斷[1]。有時懷孕時可透過超音波,在胎兒的身上檢查出來。當診斷出疾病時,癌症通常已經擴散[1]。神經母細胞瘤可以根據兒童的年齡、癌症分期以及癌症之樣貌,分為低、中、高風險[1]。 治療的結果取決於個人所處的風險群[1][4]。處置包括觀察、手術、放射線治療、化學治療或幹細胞移植[1]。低風險的嬰兒疾病通常觀察或透過手術即可獲得不錯的預後。[4]在高危疾病中,儘管採取了積極的治療長期存活率仍不到40%[4]。 ...
... is the degree of maturation of a child's bones. As a person grows from fetal life through childhood, puberty, and finishes growth as a young adult, the bones of the skeleton change in size and shape. These changes can be seen by x-ray. The "bone age" of a child is the average age at which children reach this stage of bone maturation. A child's current height and bone age can be used to predict adult height. For most people, their bone age is the same as their biological age but for some individuals, their bone age is a couple years older or younger. Those with advanced bone ages typically hit a growth spurt early on but stop growing early sooner while those with delayed bone ages hit their growth spurt ...
... is constantly being created and replaced in a process known as remodeling. This ongoing turnover of bone is a process of resorption followed by replacement of bone with little change in shape. This is accomplished through osteoblasts and osteoclasts. Cells are stimulated by a variety of signals, and together referred to as a remodeling unit. Approximately 10% of the skeletal mass of an adult is remodelled each year.[42] The purpose of remodeling is to regulate calcium homeostasis, repair microdamaged bones from everyday stress, and to shape the skeleton during growth.[citation needed] Repeated stress, such as weight-bearing exercise or bone healing, results in the bone thickening at the points of maximum stress (Wolff's law). It has been hypothesized that this is a result of bone's piezoelectric ...
The medullary cavity (medulla, innermost part) is the central cavity of bone shafts where red bone marrow and/or yellow bone marrow (adipose tissue) is stored; hence, the medullary cavity is also known as the marrow cavity. Located in the main shaft of a long bone (diaphysis) (consisting mostly of compact bone), the medullary cavity has walls composed of spongy bone (cancellous bone) and is lined with a thin, vascular membrane (endosteum). However, the medullary cavity is the area inside any bone (long, flat, etc.) that holds the bone marrow. This area is involved in the formation of red blood cells and white blood cells, and the calcium supply for bird eggshells. Intramedullary is a medical term meaning the ...
The long bones are those that are longer than they are wide. They are one of five types of bones: long, short, flat, irregular and sesamoid. Long bones, especially the femur and tibia, are subjected to most of the load during daily activities and they are crucial for skeletal mobility. They grow primarily by elongation of the diaphysis, with an epiphysis at each end of the growing bone. The ends of epiphyses are covered with hyaline cartilage ("articular cartilage"). The longitudinal growth of long bones is a result of endochondral ossification at the epiphyseal plate. Bone growth in length is stimulated by the production of growth hormone (GH), a secretion of the anterior lobe of the pituitary gland. The long bones include the femora, tibiae, and fibulae of the legs; the ...
... is constantly being created and replaced in a process known as remodeling. This ongoing turnover of bone is a process of resorption followed by replacement of bone with little change in shape. This is accomplished through osteoblasts and osteoclasts. Cells are stimulated by a variety of signals, and together referred to as a remodeling unit. Approximately 10% of the skeletal mass of an adult is remodelled each year.[42] The purpose of remodeling is to regulate calcium homeostasis, repair microdamaged bones from everyday stress, and to shape the skeleton during growth.[citation needed] Repeated stress, such as weight-bearing exercise or bone healing, results in the bone thickening at the points of maximum stress (Wolff's law). It has been hypothesized that this is a result of bone's piezoelectric ...
... secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It ... Neoplasm Metastasis (Metastasis) 11/01/2015 - "Additionally, PTHrP, MMP-1, and CTGF are candidate genes related to HCC bone ... 01/01/2015 - "Nevertheless, those with higher PTHrP expression tended to show a higher rate of bone metastasis (67.6 % vs. 45.8 ... Breast Neoplasms (Breast Cancer) 01/01/2015 - "The objective of the current study was to evaluate the association of PTHrP and ...
A murine bone scintigraphy in the evaluation of metastases revealed diffuse intense increased activity in the mandible, ... A murine bone scintigraphy in the evaluation of metastases revealed diffuse intense increased activity in the mandible, ... A murine bone scintigraphy in the evaluation of metastases revealed diffuse intense increased activity in the mandible, ... A murine bone scintigraphy in the evaluation of metastases revealed diffuse intense increased activity in the mandible, ...
... ... in patients with bone metastases (BM). In neuroendocrine neoplasms (NEN), BM are a negative prognostic factor, however tend to ... in Patients with Bone Metastases of Neuroendocrine Neoplasms. Introduction: Antiresorptive therapy (ART) with bisphosphonates ... present with distant metastases at diagnosis. Advanced stage negatively correlates with prognosis. Bone metastases (BM) are ...
National survey of radiation oncologists practice patterns regarding hormone-naïve prostate cancer with bone metastases. To ... From July 2014 to November 2016, patients diagnosed with spinal metastasis from prostate cancer using 99mTc bone scintigraphy ... Imaging studies can show metastasis in testicular cancer (TCa); however, a test for risk of metastasis in TCa has not been ... attitudes and practice patterns of radiotherapy for hormone-naïve prostate cancer with bone metastases in Japan. ...
Pain Neoplasm Metastasis Procedure: Cryoablation Study Type:. Interventional Study Design:. Intervention Model: Single Group ... Management of bone metastases. Oncologist. 2000;5(6):463-70. Review. Goetz MP, Callstrom MR, Charboneau JW, Farrell MA, Maus TP ... American Cancer Society information on bone metastases Publications: Goldfarb HA. Nd:YAG laser laparoscopic coagulation of ... Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases (MOTION). This study is ongoing, but not recruiting ...
Neoplasms, Bone Tissue. Neoplasms, Connective Tissue. Respiratory Tract Neoplasms. Thoracic Neoplasms. Neoplasms by Site. Lung ... Neoplasm Metastasis. Neoplasms, Second Primary. Sarcoma. Osteosarcoma. Sarcoma, Ewing. Lung Neoplasms. Neoplastic Processes. ... Neoplasms. Pathologic Processes. Neoplasms, Connective and Soft Tissue. Neoplasms by Histologic Type. ... Pulmonary Metastases. Lung metastases. Osteosarcomas. Ewing sarcoma. IL-2. Interleukin-2. Aldesleukin. Proleukin. Aerosol IL-2 ...
Breast Neoplasms. Prostatic Neoplasms. Neoplasm Metastasis. Neoplasms by Site. Neoplasms. Breast Diseases. Skin Diseases. ... Radiation Therapy in Treating Patients With Bone Metastases From Breast or Prostate Cancer. The safety and scientific validity ... 30 Gy in 10 fractions for palliation of painful bone metastases: preliminary results of RTOG 97-14. [Abstract] Int J Radiat ... It is not yet known which radiation therapy regimen is more effective for bone metastases. ...
Neoplasm Metastasis Thyroid Neoplasm Pheochromocytoma Adrenal Neoplasm Neuroendocrine Tumors Bone Metastases Device: ... Neoplasm Metastasis. Neoplasms, Second Primary. Neuroendocrine Tumors. Bone Neoplasms. Pheochromocytoma. Thyroid Neoplasms. ... Neoplasms, Germ Cell and Embryonal. Neoplasms by Histologic Type. Neoplasms, Nerve Tissue. Neoplasms by Site. Bone Diseases. ... Endocrine Gland Neoplasms. Adrenal Gland Neoplasms. Bone Marrow Diseases. Neoplasms. Neoplastic Processes. Pathologic Processes ...
Neoplasm Metastasis , Metastatic Cancer , Pain , Drugs , Brain Function , Near-Sighted Corrective Surgery , Chronic Diarrhea , ... Phase 3 Study on the Efficacy and Safety of Tanezumab in Patients With Cancer Pain Due to Bone Metastasis Who Are Taking ... Musculoskeletal Pain , Bone Metastases , Recurrent Respiratory Papillomatosis , Injection Port , Anal Dysplasia , Diet and ... Metastasis , Razor Bumps (Pseudofolliculitis Barbae) , Liver Metastases , Chronic Shoulder Pain , Pain (Pediatric) , ...
Bone Neoplasms / blood* * Bone Neoplasms / secondary* * Breast Neoplasms / blood* * Calcitriol / blood* * Calcium / urine ... Serum 1,25-dihydroxyvitamin D may be related inversely to disease activity in breast cancer patients with bone metastases J ... In a 6-month longitudinal study of normocalcemic patients with bone metastases undergoing hormonal therapy, serum 1,25-(OH)2D ... fell in normocalemic patients with bone metastases (52 +/- 5.3 pmol/L; P , 0.01), and were lowest in hypercalcemic patients (33 ...
... characterized by increased bone production). CaP cells produce many factors, including Wnts that are implicated in tumor- ... is unique among all cancers in that when it metastasizes to bone, it typically forms osteoblastic lesions ( ... Bone Neoplasms / secondary* * Carcinoma / metabolism* * Carcinoma / pathology * Humans * Intercellular Signaling Peptides and ... Role of Wnts in prostate cancer bone metastases J Cell Biochem. 2006 Mar 1;97(4):661-72. doi: 10.1002/jcb.20735. ...
Mechanisms of cancer metastasis to bone. J Bone Joint Surg Am. 1986;68:308-12.PubMedGoogle Scholar ... Adrenal neoplasms: CT-guided radiofrequency ablation-preliminary results. Radiology. 2004;231:225-30.PubMedCrossRefGoogle ... Mechanisms of bone metastasis. N Engl J Med. 2004;350:1655-64.PubMedCrossRefGoogle Scholar ... Radiofrequency ablation of bone metastases induces long-lasting palliation in patients with untreatable cancer. Singapore Med J ...
Care guide for Bone Metastasis (Discharge Care). Includes: possible causes, signs and symptoms, standard treatment options and ... Learn more about Bone Metastasis (Discharge Care). Associated drugs. *Neoplasm of Bone ... Bone metastasis often happens in the spine, upper arm or leg bone, ribs, hips, or skull. Cancer that spreads to a bone can ... Bone metastasis is cancer that starts in one area and then spreads to a bone. Some examples are lung, breast, thyroid, prostate ...
Care guide for Bone Metastasis. Includes: possible causes, signs and symptoms, standard treatment options and means of care and ... Learn more about Bone Metastasis. Associated drugs. *Neoplasm of Bone. IBM Watson Micromedex. *Melanoma ... What is bone metastasis?. Bone metastasis is cancer that starts in one area and then spreads to a bone. Some examples are lung ... Bone metastasis often happens in the spine, upper arm or leg bone, ribs, hips, or skull. Your risk for bone metastasis is ...
To assess the safety and efficacy of a single fraction of radiotherapy using helical tomotherapy to treat bone metastases. ... Bone Marrow Neoplasms. Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow ... SCAPHOID BONE; LUNATE BONE; TRIQUETRUM BONE; PISIFORM BONE; TRAPEZIUM BONE; TRAPEZOID BONE; CAPITATE BONE; and HAMATE BONE. ... Neoplasms By Site. A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as BRAIN NEOPLASMS ...
Differentiated thyroid cancer patients uncommonly present with bone metastasis as initial manifestation. Their molecular ... Thyroid Neoplasms. Tumors or cancer of the THYROID GLAND.. Thyroid Dysgenesis. Defective development of the THYROID GLAND. This ... BONE METASTASIS.". Differentiated thyroid cancer patients uncommonly present with bone metastasis as initial manifestation. ... PROFILE AND CLINICAL OUTCOMES IN DIFFERENTIATED THYROID CANCER PATIENTS PRESENTING WITH BONE METASTASIS.. 08:00 EDT 14th August ...
... bone pain, weakness and fevers, says the National Cancer Institute. Brittle, easily breakable bones are also present in some ... Potential symptoms of plasma cell neoplasms include fatigue, ... What Symptoms Occur With Bone Metastasis?. A: Symptoms of bone ... Physicians typically use blood and urine tests to diagnose plasma cell neoplasms. In some cases, physicians might conduct bone ... Potential symptoms of plasma cell neoplasms include fatigue, bone pain, weakness and fevers, says the National Cancer Institute ...
nächster Artikel Pilocytic astrocytoma - a juvenile neoplasm - i... Tipp. Weitere Artikel dieser Ausgabe durch Wischen aufrufen ... Ependymoma WHO II with leptomeningeal and bone metastases - report of an unusual case. Zeitschrift:. memo - Magazine of ... Ependymoma WHO II with leptomeningeal and bone metastases - report of an unusual case ...
Radiofrequency ablation uses high-frequency electric current to kill tumor cells and may help to relieve pain caused by bone ... Neoplasm Metastasis. *Neoplasms. *Neoplasms, Second Primary. .map{width:100%;height:300px;margin-bottom:15px}. Name. Location. ... RF Ablation of Painful Metastases Involving Bone. Trial Phase:. Phase 2. Minimum Age:. 18 Years. Maximum Age:. N/A ... in patients with painful bone metastases.. - Determine the safety of this regimen in these patients.. - Compare the change in ...
bone metastases. *unspecified adult solid tumor, protocol specific. *Neoplasm Metastasis. *Neoplasms. *Neoplasms, Second ... Radiographically documented metastases to the bone by bone scan, x-ray, CT scan, MRI,. or PET scan within the past 42 days. - ... S0916, A Phase II, Window Trial of the Anti-CCR2 Antibody MLN1202 in Patients With Bone Metastases. Trial Phase:. Phase 2. ... MLN1202 in patients with bone metastases.. Secondary. - To assess the feasibility of performing cross-disease site trials ...
Metastatic Neoplasm to the Bone Marrow): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis. ... When it does occur, signs and symptoms of bone metastasis include: Bone pain Broken bones Urinary incontinence Bowel ... diagnosis of bone metastases, multidisciplinary management of bone metastases in[esmo.org] ... Bone Marrow with Tumor Cells. *For histologic tissue sections, bone is stained green, whereas bone marrow and tumor cells ( ...
ObjectivesTo compare histopathological and clinical findings of metastasis to the temporal bone with previous reports and to ... Metastases to Temporal Bones From Primary Nonsystemic Malignant Neoplasms. Teresa I. Gloria-Cruz, MD; Patricia A. Schachern; ... and petrous apex was the most common site of metastases in 63 temporal bones (82.9%). Temporal bone metastases were not ... No case metastasized from a malignant neoplasm in the kidney.. Metastases extended to sites other than the temporal bone (Table ...
There have been a few reports of "aggressive" FVPTC that have metastasized hematogenously; these neoplasms have been diffusely ... Distant metastases occur in 4% to 8% of patients with PTC [4-7]. Bone metastasis is the second most common metastatic site ... distant metastases are rare and mainly include lung and bone [2]. Metastasis affecting oral and maxillofacial region is ... Malar Bone Metastasis Revealing a Papillary Thyroid Carcinoma. Ihsen Slim,1 Aida Mhiri,1 Imène Meddeb,1 Aida Goucha,2 Saïd ...
Metastases to the hand and wrist are rare, with fewer than 200 cases reported in the literature. Phalanges are more commonly ... Bone Neoplasms / radiography*, secondary*. Capitate Bone / radiography*. Female. Humans. Lymphatic Metastasis. Melanoma / ... Melanoma can give bone metastases, but we are not aware of reports of this tumour metastatising to the carpal bones. In our ... Hand metastases in a patient who is suffered melanoma should be ruled out if a lytic aggressive lesion appears on x-ray film or ...
There was no evidence of testicular, retroperitoneal, or bone marrow involvement. Multiple hepatic metastases were found. The ... Thrombocytopenia and Extragonadal Germ-Cell Neoplasm LEE J. HELMAN, M.D.; ROBERT F. OZOLS, M.D., PH.D.; DAN L. LONGO, M.D. ... We report an additional case in which idiopathic thrombocytopenia was associated with an extragonadal germ-cell neoplasm. ... Thrombocytopenia and Extragonadal Germ-Cell Neoplasm. Ann Intern Med. ;101:280. doi: 10.7326/0003-4819-101-2-280 ...
  • For cryoablation in the palliation of painful bone metastases, subject preparation, anesthesia, intra-operative monitoring, and postoperative management are identical to those of standard cryoablation routinely performed at all clinical centers participating in this study. (clinicaltrials.gov)
  • Determine the efficacy of radiofrequency ablation, in terms of pain relief at 4 weeks, in patients with painful bone metastases. (knowcancer.com)
  • Palliation of painful bone metastases is problematic and often exhausts traditional local and systemic therapies, which include opioid and non-steroidal analgesics, radiotherapy, surgery, and chemotherapy. (lww.com)
  • ABSTRACT: In the treatment of musculoskeletal neoplasms, preservation of limb function and prolongation of survival have improved over the past decade. (healio.com)
  • Abstract Adamantinoma is a rare tumour of long bones whose pathogenesis is unknown. (orthopaedicweblinks.com)
  • Furthermore, in an osteoclast-like cell formation assay using mouse bone marrow cells, Ki20227 inhibited the development of tartrate-resistant acid phosphatase-positive osteoclast-like cells in a dose-dependent manner. (aacrjournals.org)
  • Osteoclasts are derived from monocytic progenitor cells and experimentally differentiate from spleen and bone marrow cells in the simultaneous presence of macrophage colony-stimulating factor (M-CSF) and RANKL in vitro ( 16 ). (aacrjournals.org)
  • Zoledronic acid alters hematopoiesis and generates breast tumor-suppressive bone marrow cells. (harvard.edu)
  • In in vivo studies, oral administration of Ki20227 suppressed osteoclast-like cell accumulation and bone resorption induced by metastatic tumor cells in nude rats following intracardiac injection of A375 cells. (aacrjournals.org)
  • It has also been reported that transforming growth factor-β (TGF-β), which is stored in bone matrix and released by osteoclastic bone resorption, brings about enhanced PTHrP production of tumor cells in bone ( 4 ). (aacrjournals.org)
  • Bisphosphonates exert an inhibitory action on mature osteoclasts and suppress bone resorption enhanced by metastatic tumor cells by inducing apoptosis of osteoclasts ( 12 , 13 ). (aacrjournals.org)
  • According to the traditional model of metastasis, the potential to metastasize resides in a small subset of tumor cells that have acquired this property through a set of mutations that occur during the later stages of tumor progression [ 11 ]. (biomedcentral.com)
  • Atlas of Genetics and Cytogenetics in Oncology and Haematology (AGCOH) Adamantinoma of long bones is a low-grade, malignant biphasic tumor, characterized by a variety of morphological patterns, most commonly epithelial cells, surrounded by a relatively bland spindle-cell osteo-fibrous component. (orthopaedicweblinks.com)
  • The object of this open-labeled, uncontrolled pilot study was to investigate the safety and feasibility of percutaneously transplanting autologous bone marrow (ABM) cells into the myocardi. (bioportfolio.com)
  • Plasma cell neoplasms can cause plasma cells to manufacture the M protein antibody, a fault that leads to abnormally thick blood, explains the NCI. (reference.com)
  • Some scientists have identified these mutations as deletions in the mitochondrial DNA of Hürthle cells found in neoplasms and Hashimoto's thyroiditis. (wikipedia.org)
  • A pseudocapsule of fibrous connective tissue or reactive bone is formed as a host reaction by compression and layering of normal tissue cells, inflammatory cells, and newly formed blood vessels at the expanding border of the growing sarcoma. (healio.com)
  • Moreover, Ki20227 decreased the number of tartrate-resistant acid phosphatase-positive osteoclast-like cells on bone surfaces in ovariectomized (ovx) rats. (aacrjournals.org)
  • 1% or abnormal mast cells in a bone marrow aspirate. (vin.com)
  • A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often form a mass or lump, but may be distributed diffusely. (wikipedia.org)
  • Mounting evidence suggests that bone marrow-derived cells (BMDC) contribute to tumor growth, angiogenesis, and metastasis. (elsevier.com)
  • Finally, the expression levels of the bone-specific markers in PCa cells were higher in cells overexpressing PGK1 than controls. (aacrjournals.org)
  • Previously, we showed that the secretion of the glycolytic enzyme PGK1 by PCa cells enhanced the formation of extracortical-woven bone in vivo ( 11 ). (aacrjournals.org)
  • therefore, checking the state of underlying bone for disease is important if such a fracture is suspected (see the first image below). (medscape.com)
  • It is characterized by rapid tumor growth and extensive bone destruction (Figure 1 ) that can result in bone pain and pathological fracture ( 3 ). (frontiersin.org)