Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Bone loss due to osteoclastic activity.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
The process of bone formation. Histogenesis of bone including ossification.
Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
The grafting of bone from a donor site to a recipient site.
Tumors or cancer located in bone tissue or specific BONES.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
A highly glycosylated and sulfated phosphoprotein that is found almost exclusively in mineralized connective tissues. It is an extracellular matrix protein that binds to hydroxyapatite through polyglutamic acid sequences and mediates cell attachment through an RGD sequence.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.
Diseases of BONES.
Glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.
A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.
Breaks in bones.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC
The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.
Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.
The residual framework structure of the CELL NUCLEUS that maintains many of the overall architectural features of the cell nucleus including the nuclear lamina with NUCLEAR PORE complex structures, residual CELL NUCLEOLI and an extensive fibrogranular structure in the nuclear interior. (Advan. Enzyme Regul. 2002; 42:39-52)
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
A circular structural unit of bone tissue. It consists of a central hole, the Haversian canal through which blood vessels run, surrounded by concentric rings, called lamellae.
Artificial substitutes for body parts and materials inserted into organisms during experimental studies.
One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.
Tomography using x-ray transmission.
Non-collagenous, calcium-binding glycoprotein of developing bone. It links collagen to mineral in the bone matrix. In the synonym SPARC glycoprotein, the acronym stands for Secreted Protein, Acidic and Rich in Cysteine.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A member of the metalloproteinase family of enzymes that is principally responsible for cleaving FIBRILLAR COLLAGEN. It can degrade interstitial collagens, types I, II and III.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The development of bony substance in normally soft structures.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
Compounds that inhibit the enzyme activity or activation of MATRIX METALLOPROTEINASES.
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
Removal of minerals from bones during bone examination.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
A plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. The seed of Ricinus communis L. is the CASTOR BEAN which is the source of CASTOR OIL; RICIN; and other lectins.
Dissolution of bone that particularly involves the removal or loss of calcium.
An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It digests PROTEOGLYCAN; FIBRONECTIN; COLLAGEN types III, IV, V, and IX, and activates procollagenase. (Enzyme Nomenclature, 1992)
The physiological restoration of bone tissue and function after a fracture. It includes BONY CALLUS formation and normal replacement of bone tissue.
The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.
A bone morphogenetic protein that is found at high concentrations in a purified osteoinductive protein fraction from BONE. Bone morphogenetic protein 3 is referred to as osteogenin, however it may play a role in variety of developmental processes.
The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Bone in humans and primates extending from the SHOULDER JOINT to the ELBOW JOINT.
Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
The shaft of long bones.
Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.
COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.
Calcium salts of phosphoric acid. These compounds are frequently used as calcium supplements.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Elements of limited time intervals, contributing to particular results or situations.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
The thickest and spongiest part of the maxilla and mandible hollowed out into deep cavities for the teeth.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
A secreted matrix metalloproteinase that plays a physiological role in the degradation of extracellular matrix found in skeletal tissues. It is synthesized as an inactive precursor that is activated by the proteolytic cleavage of its N-terminal propeptide.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
The smallest member of the MATRIX METALLOPROTEINASES. It plays a role in tumor progression.
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.
Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.
Restoration of integrity to traumatized tissue.
A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.
Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Established cell cultures that have the potential to propagate indefinitely.
A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.
Pathologic deposition of calcium salts in tissues.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.
The spinal or vertebral column.
Operative immobilization or ankylosis of two or more vertebrae by fusion of the vertebral bodies with a short bone graft or often with diskectomy or laminectomy. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed, p236; Dorland, 28th ed)
A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.
Matrix metalloproteinases that are associated with the CELL MEMBRANE, either through transmembrane domains or GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORS. Membrane-type matrix metalloproteinases may act within the pericellular environment to influence the process of CELL MIGRATION.

Noncollagenous bone matrix proteins, calcification, and thrombosis in carotid artery atherosclerosis. (1/363)

Advanced atherosclerosis is often associated with dystrophic calcification, which may contribute to plaque rupture and thrombosis. In this work, the localization and association of the noncollagenous bone matrix proteins osteonectin, osteopontin, and osteocalcin with calcification, lipoproteins, thrombus/hemorrhage (T/H), and matrix metalloproteinases (MMPs) in human carotid arteries from endarterectomy samples have been determined. According to the recent American Heart Association classification, 6 of the advanced lesions studied were type V (fibroatheroma) and 16 type VI (complicated). Osteonectin, osteocalcin, and osteopontin were identified by monoclonal antibodies IIIA(3)A(8), G12, and MPIIIB10(1) and antiserum LF-123. Apolipoprotein (apo) AI, B, and E; lipoprotein(a); fibrinogen; fibrin; fragment D/D-dimer; MMP-2 (gelatinase A); and MMP-3 (stromelysin-1) were identified with previously characterized antibodies. Calcium phosphate deposits (von Kossa's stain) were present in 82% of samples (3 type V and 15 type VI). Osteonectin was localized in endothelial cells, SMCs, and macrophages and was associated with calcium deposits in 33% of type V and 88% of type VI lesions. Osteopontin was distributed similarly to osteonectin and was associated with calcium deposits in 50% of type V and 94% of type VI lesions. Osteocalcin was localized in large calcified areas only (in 17% of type V and 38% of type VI lesions). ApoB colocalized with cholesterol crystals and calcium deposits. Lipoprotein(a) was localized in the intima, subintima, and plaque shoulder. Fibrin (T/H) colocalized with bone matrix proteins in 33% of type V and 69% of type VI lesions. MMP-3 was cytoplasmic in most cells and colocalized with calcium and fibrin deposits. MMP-2 was less often associated with calcification. The results of this study show that osteonectin, osteopontin, and osteocalcin colocalized with calcium deposits with apoB, fibrin, and MMP-3 in advanced, symptomatic carotid lesions. These data suggest that the occurrence of T/H might contribute to dystrophic arterial calcification in the progression and complications of atherosclerosis.  (+info)

Xenogenic demineralized bone matrix: osteoinduction and influence of associated skeletal defects in heterotopic bone formation in rats. (2/363)

Demineralized bone matrix (DBM) was ectopically implanted in 36 male Wistar rats. In 18 of the animals a bone defect in the femoral condyles was also created: the left was filled with DBM and the right was left empty as a control. The animals were killed after 2, 4 and 6 weeks and new bone was histologically evaluated, comparing ectopic bone formation with or without distant bone injury. Results showed: (1) osteoinductivity of xenogenic DBM, and (2) earlier mineralization of ectopically implanted DBM in the group with associated skeletal injury. Our results show that xenogenic bone matrix acts as an osteoinductive material and that skeletal injury improves osteogenesis at distant sites.  (+info)

Changes in the orientation of collagen fibers on the superficial layer of the mouse tibial bone after denervation: scanning electron microscopic observations. (3/363)

This study was undertaken to evaluate the relationship between the mechanical stress loaded onto the bone and the orientation of collagen fibers formed by osteoblasts. The femoral, obturator, and sciatic nerves in the left posterior legs of 7-week-old mice were exposed and electroscissored to reduce the mechanical stress loaded onto the leg. Four weeks after operation, the tibial bones in the control and denervated legs were removed and observed by scanning electron microscopy (SEM) after NaOCl treatment. In the control right tibia, collagen fibers on the superficial bone matrix tended to be arranged parallel to the longitudinal axis of the bone. However, the arrangement of collagen fibers in the left tibia, which were immobilized for 4 weeks by denervation, was disorganized and ran in random directions. The findings suggest that the direction of collagen fibers in the bone changes in response to the mechanical stress loaded onto the bone, probably due to changes in the activity of osteoblasts in the denervated leg.  (+info)

Bone morphogenetic proteins in human bone regeneration. (4/363)

Recently, the first clinical reports on bone regeneration by two recombinant human bone morphogenetic proteins (rhBMPs), BMP-2 and BMP-7 (also named osteogenic protein-1, OP-1) have been published (1-4). Although both BMPs were able to support bone regeneration, a significant variation in individual response was observed with both proteins. Animal studies and laboratory experiments reveal a number of conditions that influence the osteoinductivity of BMP, such as BMP concentration, carrier properties and influence of local and systemic growth factors and hormones. In this paper, these studies and the clinical reports are reviewed, and the conditions that modulate the BMP-dependent osteoinduction are discussed. The information may provide clues as to how the performance of recombinant human BMP as bone-graft substitute in humans can be improved.  (+info)

The cell biology of osteoclast function. (5/363)

Osteoclasts are multinucleated cells responsible for bone resorption. They have developed an efficient machinery for dissolving crystalline hydroxyapatite and degrading organic bone matrix rich in collagen fibers. When initiating bone resorption, osteoclasts become polarized, and three distinct membrane domains appear: a ruffled border, a sealing zone and a functional secretory domain. Simultaneously, the cytoskeleton undergoes extensive re-organisation. During this process, the actin cytoskeleton forms an attachment ring at the sealing zone, the membrane domain that anchors the resorbing cell to bone matrix. The ruffled border appears inside the sealing zone, and has several characteristics of late endosomal membrane. Extensive vesicle transport to the ruffled border delivers hydrochloric acid and proteases to an area between the ruffled border and the bone surface called the resorption lacuna. In this extracellular compartment, crystalline hydroxyapatite is dissolved by acid, and a mixture of proteases degrades the organic matrix. The degradation products of collagen and other matrix components are endocytosed, transported through the cell and exocytosed through a functional secretory domain. This transcytotic route allows osteoclasts to remove large amounts of matrix-degradation products without losing their tight attachment to underlying bone. It also facilitates further processing of the degradation products intracellularly during the passage through the cell.  (+info)

109Cd K x ray fluorescence measurements of tibial lead content in young adults exposed to lead in early childhood. (6/363)

OBJECTIVES: Tibia lead measurements were performed in a population of 19-29 year old people who had been highly exposed to lead in childhood to find whether lead had persisted in the bone matrix until adulthood. METHODS: (109)Cd K x ray fluorescence was used to measure the tibia lead concentrations of 262 exposed subjects and 268 age and sex matched controls. Questionnaire data allowed a years of residence index to be calculated for exposed subjects. A cumulative blood lead index was calculated from the time weighted integration of available data of blood lead. RESULTS: The mean (SEM) difference between exposed and control men was 4.51 (0.35) micrograms Pb/g bone mineral, and between exposed and control women was 3.94 (0. 61) micrograms Pb/g bone mineral. Grouped mean bone lead concentrations of exposed subjects were predicted best by age. When exposed and control subjects' data were combined, grouped mean bone lead concentrations were predicted best by cumulative blood lead index. The years of residence index was neither a good predictor of bone lead concentrations for exposed subjects nor for exposed and control subjects combined. Finally, exposed subjects had increased current blood lead concentrations that correlated significantly with bone lead values. CONCLUSION: Bone lead concentrations of exposed subjects were significantly increased compared with those of control subjects. Lead from exposure in early childhood had persisted in the bone matrix until adulthood. Exposed subjects had increased blood lead concentrations compared with controls. Some of this exposure could be related to ongoing exposure. However, some of the increase in blood lead concentration in adult exposed subjects seemed to be a result of endogenous exposure from increased bone lead stores. The endogenous exposure relation found for men was consistent with reported data, but the relation found for women was significantly lower. Further research is needed to find whether the observed differences are due to sex, or pregnancy and lactation.  (+info)

The roles of annexins and types II and X collagen in matrix vesicle-mediated mineralization of growth plate cartilage. (7/363)

Annexins II, V, and VI are major components of matrix vesicles (MV), i.e. particles that have the critical role of initiating the mineralization process in skeletal tissues. Furthermore, types II and X collagen are associated with MV, and these interactions mediated by annexin V stimulate Ca(2+) uptake and mineralization of MV. However, the exact roles of annexin II, V, and VI and the interaction between annexin V and types II and X collagen in MV function and initiation of mineralization are not well understood. In this study, we demonstrate that annexin II, V, or VI mediate Ca(2+) influx into phosphatidylserine (PS)-enriched liposomes, liposomes containing lipids extracted from authentic MV, and intact authentic MV. The annexin Ca(2+) channel blocker, K-201, not only inhibited Ca(2+) influx into fura-2-loaded PS-enriched liposomes mediated by annexin II, V, or VI, but also inhibited Ca(2+) uptake by authentic MV. Types II and X collagen only bound to liposomes in the presence of annexin V but not in the presence of annexin II or VI. Binding of these collagens to annexin V stimulated its Ca(2+) channel activities, leading to an increased Ca(2+) influx into the liposomes. These findings indicate that the formation of annexin II, V, and VI Ca(2+) channels in MV together with stimulation of annexin V channel activity by collagen (types II and X) binding can explain how MV are able to rapidly take up Ca(2+) and initiate the formation of the first crystal phase.  (+info)

Localization of alkaline phosphatase and osteopontin during matrix mineralization in the developing cartilage of coccygeal vertebrae. (8/363)

We observed the manner in which alkaline phosphatase (ALPase) and osteopontin were localized in the cartilage and intramembranous bone of coccygeal vertebrae during matrix mineralization, shedding considerable light on the manner in which they develop. In the cartilage matrix of coccygeal vertebrae, we observed the localization of ALPase activity in the boundary of the proliferative and the hypertrophic zones. Granular nodules of mineralization were consistently found in the boundary of both zones, and increased in size when close to the hypertrophic zone. While osteopontin was rarely present in the early stages of mineralization, its localization along the margins of mineralized matrices in the hypertrophic zone was prominent. In contrast to cartilage, mineralized nodules in the intramembranous bone in the mid-portion of the vertebra displayed osteopontin-immunoreactivity, indicating its early synthesis and subsequent accumulation to early-stage mineralized nodules. When blood vessels, accompanied by osteoblastic and osteoclastic cell populations, invaded the cartilage, osteopontin was localized in the lower region of the hypertrophic zone, despite its maintaining the localization of ALPase and early-stage mineralization. Thus, our investigation demonstrated ALPase activity consistent with early-stage mineralization in the cartilage matrix. However, the fact that osteopontin-localization could not be pinpointed might account for its multifunctionality as concerns both the regulation of mineralization and the attachment of migrating osteogenic and osteoclastic cells to the mineralized matrix.  (+info)

Rabbit bone marrow cells were cultured in diffusion chambers with or without decalcified bone matrix. The chambers were assayed after 28 days for alkaline phosphatase activity, deoxyribonucleic acid (DNA), calcium, and phosphorus contents. Morphologically, marrow cells incubated with or without matrix differentiated to form bone and cartilage. With bone matrix, the calcium and phosphorus contents of chambers were significantly higher than control chambers. Alkaline phosphatase activity and DNA content were not influenced by inclusion of bone matrix. These results indicate that bone matrix constituents exert a stimulatory effect on bone formation from marrow cells. This osteogenic stimulation could be due to the influence of an osteoinductive factor and/or to stimulation of osteoprogenitor cells known to be present in the marrow.
The global autologous matrix-induced chondrogenesis market has five major regional segments that divide it in terms of geography. These regions are North America, Europe, Asia Pacific, Middle East and Africa, and Latin America. Currently, the autologous matrix-induced chondrogenesis market is globally dominated by the regional segment of North America. The region is expected to continue to be a leading contributor for the given period of forecast of 2018 to 2028. There are multiple factors that are responsible for the development of the global autologous matrix-induced chondrogenesis market. Some of the important driving factors for market growth are growing geriatric population and increasing sports-related injuries in the region.. On the other hand, the regional segment of Asia Pacific is projected to be the fastest developing region of the global autologous matrix-induced chondrogenesis market. One of the key reasons behind the growth of the regional segments is the fast development of the ...
4. This activity was designed for remote learning where my anatomy students could learn the parts of the bone matrix. ... with one another and with cells outside of the bone matrix. Connective tissue is found between other tissue types and organs. There are two types of bone tissue: compact and spongy. Fresh bone allografts may be rejected by the hosts immune system. Bones are organs that consist primarily of bone tissue, also called osseous tissue. are embedded. Bones are composed of two types of tissue: 1. The extracellular matrix can be thought of as a suspension of macromolecules that supports everything from local tissue growth to the maintenance of an entire organ.These molecules are all secretions made by neighboring cells. Extracellular Matrix Definition. These treatments may involve the use of biochemical techniques to induce tissue regeneration directly at the site or the use of transplantation techniques employing differentiated cells or stem cells. Ligament. Cartilage smoothen bone ...
Demineralized bone matrix fibers and a demineralized bone matrix composition are provided. The demineralized bone matrix fibers have an average fiber length in the range from about 250 μm to about 2 mm and an aspect ratio of greater than about 4. The demineralized bone matrix composition includes demineralized bone matrix fibers and a biocompatible liquid in an amount to produce a coherent, formable mass. The formable mass retains its cohesiveness when immersed in a liquid. Methods for making the demineralized bone matrix fibers and composition are also provided.
A comparison of bone matrix and tendon with particular reference to glycoprotein content.: Bone matrix and tendon are compared in terms of their carbohydrate an
Inhibition of PPAR gamma 2 by BADGE and Vitamin D in Male Mice Increases Osteoblastogenesis and Inhibits Bone Matrix Mineralization Leading to Osteomalacia. Conference Proceedings ...
TY - JOUR. T1 - Gastrointestinal digestates of Grana Padano and Trentingrana cheeses promote intestinal calcium uptake and extracellular bone matrix formation in vitro. AU - Rossi, Filippo. AU - De Luca, Paola. AU - Bruschi, Sara. AU - Maggioni, Maurizio. AU - Ferraretto, Anita. AU - Maggioni, Margherita. AU - Stuknytė, Milda. AU - Cattaneo, Stefano. AU - Bottani, Michela. AU - Fiorilli, Amelia. AU - De Noni, Ivano. PY - 2016. Y1 - 2016. N2 - In the present work, Grana Padano (GP) and Trentingrana (TN) cheeses at different ripening time were in vitro digested. To study calcium uptake and utilization, the intact digestates (selected doses that do not alter cell viability and TEER) were administered to Caco2/HT- 29 70/30 cells, cultured on a semipermeable membrane in transwells, as a model of human intestinal epithelium. Intact digestates as well as the whole basolateral solutions (miming the passage of digestates through intestinal cells before reaching the blood flow and bone) in parallel were ...
Today, DePuy Synthes*, in collaboration with LifeNet Health , launches ViviGen Formable Cellular Bone Matrix**, a second generation cellular allograft used to assist in the formation
If you or a loved one have received a tuberculosis diagnosis because of FiberCel Viable Bone Matrix implantation, you may be eligible for compensation. Contact the legal team at WKW today.
The extracellular matrix (ECM) has been viewed as a static three dimensional scaffold that supports cells and tissues. However, our recent molecular imaging stu...
DePuy Synthes, part of J&J, announced the release of its CONFORM SHEET demineralized cancellous bone scaffold thats designed for implantation during
Radiating in all direction from the lacunae are minute canals called canaliculi. Cells mature so that they are able to carry out their function in the body. Osteoid is unmineralized bone matrix. There are three types of bone cells. B. Connective. They are connected together by very fine tentacle-like cytoplasmic processes. Cells at the early stages in the development of the embryo are stem cells. B cells are a specific type of white blood cell called a lymphocyte. It also houses DNA (deoxyribonucleic acid), the cells hereditary material. B cell: A type of white blood cell and, specifically, a type of lymphocyte. T cell-independent activation of B cell. The Central Vacuole. Stem cells typically have the capacity to mature into many different cell types. They secrete osteoid, which forms the bone matrix. A naive T cell (T h 0 cell) is a T cell that has differentiated in the thymus, and successfully undergone the positive and negative processes of central selection in the thymus.Among these are ...
The spines in Group I demonstrated higher rates of radiographically evident fusion at eight weeks than did the spines in Group III or Group IV (p , 0.05). Manual testing of the spines at four weeks revealed variable fusion rates (five of six in Group I, two of six in Group II, and none of six in Group Ill). At eight weeks, all six spines in Group I, three of the six in Group II, and no spine in Group III or IV had fused. Histologic analysis of the spines in Groups I, II, and III demonstrated varying amounts of residual demineralized bone matrix and new bone formation. Group-1 spines demonstrated the most new bone formation. ...
D. B. Horváthy, Vácz, G., Szabó, T., Szigyártó, I. Cs., Torõ, I., Vámos, B., Hornyák, I., Renner, K., Klára, T., Szabó, B. T., Dobõ-Nagy, C., Doros, A., and Lacza, Z., Serum albumin coating of demineralized bone matrix results in stronger new bone formation, Journal of Biomedical Materials Research - Part B Applied Biomaterials, vol. 104, no. 1, pp. 126 - 132, 2016. ...
Hi I have some skeletal animation that is driven in the vertex shader, each vertex has a selection of bones that influence it and a bone matrix is passed representing all the bones that can influence and the eventual result is a perfect skeleton. This is a simple matrix multiplication in the shader. Id like to know when my mouse cursor is selecting any of the bone meshes that are drawn as part of the skeleton. Because all the grunt work is done in the shader I dont know the model matrix
TY - JOUR. T1 - Studies on the biology of fish bone-II bone matrix changes during resorption. AU - Weiss, Roy E.. AU - Watabe, Norimitsu. PY - 1978. Y1 - 1978. N2 - 1. 1. The present investigation describes changes in the water-soluble organic matrix during bone resorption in the acellular-boned fish Tilapia macrocephala. Bone resorption was induced after scale removal. 2. 2. Bone carbohydrate concentration decreased 49.2% in 2 days and 93.7% 6 days after scale removal. 3. 3. Bone calcium concentration remained the same at 2 and 4 days but decreased by 63% 6 days after scale removal. 4. 4. The soluble organic matrix was found to be altered prior to mineral removal. 5. 5. In normal bone matrix, two heat-labile, calcium-binding components were identified: One (molecular weight 15,000), not sensitive to beta-glucuronidase, and the other (molecular weight 6000), which was sensitive to beta-glucuronidase. Uronic acid was found to be associated with these components. 6. 6. In resorbing bone matrix ...
The radioactively labelled constituents present in bone matrix were compared 12 days after injection of either [(14)C]glucosamine or plasma [(14)C]glycoprotein. Both precursors are utilized in the synthesis of organic matrix by bone tissue. Cortical bone from animals injected with [(14)C]glucosamine contains radioactivity derived from glucosamine and plasma glycoproteins and all glycoprotein fractions are labelled. Plasma [(14)C]glycoprotein labels the less acidic glycoproteins to a greater extent than the more acidic components. An antibody has been raised against the less-acidic-glycoprotein fraction of bone. The latter contains a glycoprotein of alpha-mobility that appears to be concentrated specifically in bone tissue and which is present also in plasma. This alpha-glycoprotein accounts for a large proportion of the components labelled and retained in bone matrix after [(14)C]glucosamine injection.
TY - JOUR. T1 - The effects of cytokines and growth factors on osteoblastic cells. AU - Mundy, G. R.. AU - Boyce, B.. AU - Hughes, D.. AU - Wright, K.. AU - Bonewald, L.. AU - Dallas, S.. AU - Harris, S.. AU - Ghosh-Choudhury, N.. AU - Chen, D.. AU - Dunstan, C.. AU - Izbicka, E.. AU - Yoneda, T.. N1 - Copyright: Copyright 2014 Elsevier B.V., All rights reserved.. PY - 1995/8. Y1 - 1995/8. N2 - In this short review, some regulatory mechanisms that are involved in the control of normal bone formation are proposed, based on several in vivo and in vitro models our group has utilized recently to study osteoblast differentiation and mineralized bone matrix formation. Of course, these proposals must be assessed in the light of the limitations of the models, which probably represent a simplification of the complex and different ways in which normal mammalian bone is formed at different sites. Nevertheless, it is likely that the same general types of control mechanisms are active in each of the ...
This bone health supplement is balanced and synergistic, a product of extensive research into the current medical and scientific understanding of bone. Among this products unique benefits:. • Diverse nutrient spectrum for comprehensive bone maintenance.. • Supports bone matrix formation, a requisite for calcium utilization.. • Provides a generous 1800 IU of vitamin D3 for healthy bone calcification.. • Its vitamin K2 (as MK-7) surpasses other K vitamin forms in supporting bone formation.. • Provides optimized allowances of calcium, magnesium, and other essential bone minerals.. • Avoids technical shortcuts that use magnesium oxide or other poorly absorbed ingredients.. • Offers potential benefits that extend beyond bone to promote overall health and wellbeing.. Calcium Is Not Sufficient to Build Bone.. Clinical studies have established that high-calcium dietary supplements by themselves do not reliably increase bone density or reduce fracture risk. Many other nutrients are ...
It is not possible to say if this is a direct effect of estrogens on bone or the result of secondary effects but it suggests that in transsexuals receiving high dose estrogen therapy there is a decrease in bone matrix formation.
A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.
This animal experiment compared the regenerative processes within defined bony defects of the porcine skull after delivery of routinely utilized bone graft materials: anorganic bone matrix (ABM) and an identical ABM carrying the cell binding peptide P-15. Particulated autogenous bone was used as a c …
Osteoblasts are responsible for deposition of the mineralized bone matrix. Osteoblasts attach to the surface of the bone matrix, proliferate, and secrete type I collagen and bone-specific non-collagenous proteins such as osteocalcin. These proteins are crucial for mineralization of the bone matrix ...
Results: At the time of sacrifice, statistically significant differences between the four types of defects in the total area of bone regeneration, percentage of neoformed bone matrix, medullary space, or contact between particulate biomaterial and neoformed bone matrix were not found. All defects showed a significant increase in neoformed bone matrix as sacrifice was delayed, but a uniform pattern was not followed. Only defects treated with ß-TCP-Fn-ADSCs showed a significant increase in the bone regeneration area when animals sacrificed at 3 months were compared to those sacrificed at 1 month (P = .006 ...
August 18, 2008 - ETEX Corp. launched EquivaBone, a bone graft substitute that remodels and is replaced with new bone during the healing process.. EquivaBone is a proprietary combination of osteoinductive Demineralized Bone Matrix (DBM) and ETEXs osteoconductive nanocrystalline calcium phosphate. ETEX now offers reportedly the first combination product that is both moldable and injectable and sets hard once implanted. In addition, osteoinductivity of the DBM is certified after sterilization, by lot, for the entirety of shelf life.. Both trauma and spine fusion data were included in the 510k submission which received FDA clearance on April 28, 2008. EquivaBone is intended for use in filling bone voids or defects of the skeletal system (including extremities, pelvis, and spine) that are not intrinsic to the stability of the bone structure.. For more information: www.etexcorp.com. ...
1 uM dexamethasone, 10 mM B glycerolphosphate and 50 uM ascorbic new post acid for 14 days. The in duction medium was changed every 3 days, and the bone matrix mineralization was evaluated by Alizarin red S staining. The ARS was ex tracted by adding 10% cetylpyridinium chloride in 8 mM Na2HPO4 and 1. 5 mM KH2PO4 and the absorbance was mea sured by SpectraMax 190 ELISA plate reader at 550 nm. Cell proliferation assay To evaluate the cell proliferation, MTT 2,5 diphenyl 2H tetrazoliumbromide assay was performed as described previously. Briefly, cells were seeded at the density of 1. 5 103 cells/well in 96 well plate and cultured without or with various concentrations of OGT2115. Cells were analyzed every two days by adding Inhibitors,Modulators,Libraries 10 uL of the MTT to each well and the cells were continued to culture for 4 hr.. After the incubation, the supernatant was discarded and 100 uL of dimethyl sulfoxide was added to each well to dissolve the formazan. The number of cells was ...
Optium DBM Gel, TGEL10,Demineralized bone matrix dispensed in a syringe. DBM will be free of foreign matter. Demineralized bone matrix particle size 125 to 850 . Glycerol 70-88% by weight. Calcium content less than 8%.,medicine,medical supply,medical supplies,medical product
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecules storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters. ...
90% of bone matrix proteins are made of collagen, which is crucial for bone strength just as much as calcium. Read about vegetarian protein sources here!
Affiliation:Okayama University Dental School,歯学部,助教授, Research Field:Morphological basic dentistry, Keywords:Immunohistochemistry,免疫組織化学,骨芽細胞,初期石灰化,歯原性腫瘍,Cementum,Bone matrix protein,Pathogenesis,口腔粘膜上皮,コラーゲン, # of Research Projects:6, # of Research Products:0
Matrix OI is a compressible stem cell containment matrix that is derived from 100% human bone. Matrix OI is 100% lot to lot tested for osteoinductivity post sterilization to ensure the presence of bone morphogenic protiens and growth factors. BMPs promote mesenchymal (BMA) cells to differentiate into chondrocytes and osteoblasts that lead to bone formation. Preserved native BMPs provide for an unparalleled osteoactive grafting material. Matrix OI can be hydrated with the patients own stem cells, BMA, growth factors, PRP or with an antibiotic solution.. Matrix OI is indicated for use in spine surgeries, scoliosis, lateral gutters, orthopedics, bone voids, reconstruction, CMF, non-unions, foot and ankle, and dental procedures. When hydrated, matrix OI is a compressable scaffold that will contour with the defect.. ...
View indications, safety, and warnings for Grafton Bone Graft, a demineralized bone matrix (DBM), used with oral-maxillofacial surgery.
Filion TM, Li X, Mason-Savas A, Kreider JM, Goldstein SA, Ayers DC, Song J. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng Part A. 2011 Feb; 17(3-4):503-11 ...
TY - JOUR. T1 - The role of a composite, demineralized bone matrix and bone marrow in the treatment of osseous defects. AU - Tiedeman, J. J.. AU - Garvin, K. L.. AU - Kile, T. A.. AU - Connolly, J. F.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - The efficacy of demineralized bone matrix (DBM) used alone and with bone marrow as a graft material in the treatment of osseous defects was evaluated in 48 patients. Of these 48 patients, 39 were available to follow up and review. Follow up averaged 19 months for all patients. In the entire series, 30 of 39 patients demonstrated osseous union for a 77% success rate. Patients with fracture nonunion represented the most recalcitrant group clinically, with union achieved in only 61% of these cases. Overall, the 39 patients grafted with DBM demonstrated healing that was comparable to results achieved with standard lilac crest bone graft. The results indicate the DBM and marrow composite grafting is a suitable alternative to autologous iliac crest bone graft for use ...
DOI: 10.11607/prd.00.0510 The effect of the pure-phase beta-tricalcium phosphate (beta-TCP) Cerasorb on bone regeneration was evaluated in hollow titanium cylinders implanted in the posterior jaws of five volunteers. Beta-TCP particles were inserted inside the cylinders and harvested 6 months after placement. The density of the newly formed bone inside the bone-growing chambers measured 27.84% 24.67% in test and 17.90% 4.28% in control subjects, without a statistically significant difference. Analysis of the histologic specimens revealed that the density of the regenerated bone was related to the density of the surrounding bone. The present study demonstrates the spontaneous healing of infrabony artificial defects, 2.5 mm diameter, in the jaw. The pure beta-TCP was resorbed simultaneously with new bone formation, without interference with the bone matrix formation. (Int J Periodontics Restorative Dent 2003;23:69 77 ...
The aim here was to explore a new graft material that excludes the need to harvest autogenous bone from patients. Forty-two critical-size (10 x 15 mm) defects were created in rabbit mandibles bilaterally. Five groups of six defects each were grafted with autogenous endochondral (EC) bone, autogenous intramembranous (IM) bone, fresh-frozen allogeneic IM bone only, fresh-frozen allogeneic IM bone and demineralized bone matrix powder prepared from intramembranous bone (DBM IM) only, and fresh-frozen allogeneic IM bone and basic fibroblast growth factor (bFGF) mixed with DBM IM powder. The remaining defects were used as controls. Three weeks after surgery, the defects were retrieved for histological analysis. The amount of new bone formation was quantified by image analysis. No bone formed across the defect in the controls; 224% more new bone formed in defects grafted with composite allogeneic IM bone/DBM IM than in those grafted with allogeneic IM bone alone (p < 0.001); 550% more new bone was ...
CIANCAGLINI, P; PIZAURO, J M; LEONE, F A. Modulation of phosphohydrolase activity of polidocanol solubilized matrix-induced alkaline phosphatase by metal ions. Arquivos de Biologia e Tecnologia[S.l: s.n.], 1989 ...
The highly intertwined, cross-linked structure of collagen makes it reasonable that fragments of this molecule could survive for 68 million years. Even if the individual protein strands break down, the fiber would still remain largely intact because of all the association points. Once the protein strand breaks, the fragments are held in close proximity by the contact points. This forced closeness allows for broken strands to occasionally rejoin and reform the original protein. If the broken strands were not held juxtaposed to each other, the fragments would diffuse away from each other, thus, preventing the reversal of the degradation process.. Finally, collagens association with the bone matrix provides added stability to the collagen proteins. Within the bone matrix, collagen fibers adsorb to the mineral component of bone. The contact with the surface protects the protein and keeps the pieces of collagen juxtaposed whenever the protein strands break.. Collagens abundance further explains its ...
dbm_store_metadata. Boolean value which determines if the metadata in DBM is stored or not.. dbm_berkeley_flags. Hash reference with additional flags for BerkeleyDB::Hash instantiation.. dbm_version. Readonly attribute containing the version of DBD::DBM.. f_meta. In addition to the attributes DBD::File recognizes, DBD::DBM knows about the (public) attributes col_names (Note not dbm_cols here!), dbm_type, dbm_mldbm, dbm_store_metadata and dbm_berkeley_flags. As in DBD::File, there are undocumented, internal attributes in DBD::DBM. Be very careful when modifying attributes you do not know; the consequence might a destroyed or corrupted table.. dbm_tables. This attribute provides restricted access to the table meta data. See f_meta and f_meta in DBD::File for attribute details.. dbm_tables is a tied hash providing the internal table names as keys (accessing unknown tables might create an entry) and their meta data as another tied hash. The table meta storage is obtained via the ...
Remodeling a kitchen to add additional cabinets to existing ones also means adding extra support. In a similar respect, bone remodeling alters bone structure without adversely affecting bone strength. What divalent cation is required to create additional bone matrix ...
Health, ...A study conducted at the University of Granada hasdemonstrated that ib...In vitro tests demonstrated that unlike other NSAIDs when a therapeuti...Osteoblast cells are bone cells that synthesize the bone matrix. Conse...Positive Results ...,A,study,demonstrates,that,ibuprofen,improves,bone,repair,after,surgery,or,a,fracture,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
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You must limit the use of your damaged limb. Relax and accept that you cannot do the things you used to normally do. If you do, try to do things too soon, you will possibly lengthen the time it takes to get back to normal. But, right now, lets talk about how you might help to speed your recovery time. Because bone is about 70% mineral content, it is high in phosphorus, magnesium, silicon, zinc, and of course, calcium, along with some other minerals. Bone is also very high in protein content. A high-protein diet will provide some of the building blocks needed to synthesize a new bone matrix.. Plant-based proteins are recommended, such as nuts, oats, and quinoa, instead of animal and dairy proteins which contain more fat. Amino acids found in protein, such as lysine, arginine, glycine, cysteine and glutamine are responsible for the absorption of calcium and the regeneration of bone tissue. Anti-oxidants, like vitamins E, C and K, may aid in fracture healing by suppressing inflammation. By adding ...
The width measurement of 1895 millimeters corresponds to the width of the Fiat Scudo Combi 2012 without exterior mirrors. Dimensiuni. Fiat car specs are listed here. The model range is available in the following body types starting from the engine/transmission specs … The wheelbase lengths are 3000mm (SWB). Volumul necesar. Fiat Scudo Models Price and Specs. Becurile pentru lămpile de stop la Fiat Scudo. Were here to help. Search for immediate answers to FAQs or contact our customer care team via phone or email. Volumul de ulei, Lichidul în sistemul de frânare Fiat Scudo. Fiat Scudo - Find out the correct alloy wheel fitment, PCD, offset and such specs as bolt pattern, thread size(THD), center bore(CB) for all model years of Fiat Scudo. Becurile pentru farurile anticeaţă la Fiat Scudo. The interior dimensions (length) of the Fiat Scudo … The Fiat Scudo is powered by Multijet engines which are offered with a choice of 90hp, 120 hp, 140 hp and 165 hp. Dimensions … The interior width of ...
BMP3 Human Recombinant produced in E.coli is a non-glycosylated disulfide linked homodimer containing 2 chains of 110 amino acids.
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The Fiat 500 is not new news, but stop! (collaborate and listen) there is something in this certain 500 that makes it harp back to its predecessor more than
阿伏苯宗 (英語:Avobenzone,商品名: Parsol 1789, Eusolex 9020, Escalol 517 等。INCI名稱:Butyl Methoxydibenzoylmethane) 阿伏苯宗為USAN名稱。為一使用於防曬產品中的脂溶性成分,能夠吸收所有波段的 UVA(約 315至400奈米),是二苯甲酰甲烷(DBM)的衍生物。其中,阿伏苯宗對於波長 357奈米的 UVA吸收率最高[1]。. 因為相較於其他化學防曬劑它能夠吸收相當大範圍波段的紫外光,因此被廣泛地使用於許多標榜廣譜防曬產品中。. ...
Fujisawa R (March 2002). "[Recent advances in research on bone matrix proteins]". Nihon Rinsho. Japanese Journal of Clinical ... Lumachi F, Camozzi V, Tombolan V, Luisetto G (September 2009). "Bone mineral density, osteocalcin, and bone-specific alkaline ... noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein in chick bone. Because ... "Changes of bone formation markers osteocalcin and bone-specific alkaline phosphatase in postmenopausal women with osteoporosis ...
Local enzymatic removal of inhibitors in the extracellular matrix". Bone. 138: 115447. doi:10.1016/j.bone.2020.115447. PMID ... OPN expression in bone predominantly occurs by osteoblasts and osteocyctes (bone-forming cells) as well as osteoclasts (bone- ... The inorganic part of bone is the mineral hydroxyapatite, Ca10(PO4)6(OH)2. Loss of bone may lead to osteoporosis, as the bone ... OPN at bone surfaces is located in a thin organic layer, the so-called lamina limitans. The organic part of bone is about 20% ...
Takeuchi Y, Kodama Y, Matsumoto T (December 1994). "Bone matrix decorin binds transforming growth factor-beta and enhances its ... Takeuchi Y, Kodama Y, Matsumoto T (December 1994). "Bone matrix decorin binds transforming growth factor-beta and enhances its ... Fujisawa R (March 2002). "[Recent advances in research on bone matrix proteins]". Nihon Rinsho. Japanese Journal of Clinical ... bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone". The Journal of Biological ...
... beyond ground glass bone matrix". Insights into Imaging. 9 (6): 1035-1056. doi:10.1007/s13244-018-0666-6. ISSN 1869-4101. PMC ... "Age-Related Changes and Effects of Bisphosphonates on Bone Turnover and Disease Progression in Fibrous Dysplasia of Bone". ... A bone age examination should be performed to evaluation for skeletal maturation. Boys and men should have a screening ... McCune-Albright syndrome is a complex genetic disorder affecting the bone, skin and endocrine systems. It is a mosaic disease ...
"Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix". Biomaterials. 31 (23): 6004-12. doi:10.1016/j. ... with potential applications in bone and cartilage regeneration, angiogenesis for ischemia or peripheral artery disease, cancer ... amphiphiles with the ability to self-assemble into nanoscale filaments that mimic components of the extracellular matrix. ...
2005). "Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone". J. Bone Miner. Metab ... MacDougall M, Simmons D, Gu TT, Dong J (2003). "MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin ... "Entrez Gene: MEPE matrix, extracellular phosphoglycoprotein with ASARM motif (bone)". Petersen DN, Tkalcevic GT, Mansolf AL, ... Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL (1 July 2000). "MEPE, a new gene expressed in bone marrow ...
The alveolar bone between two neighboring teeth is the interdental septum (or interdental bone). Inorganic matrix Alveolar bone ... The supporting alveolar bone consists of both cortical bone and trabecular bone. The cortical bone, or cortical plates, ... Primary bone grafting is believed to: eliminate bone deficiency, stabilize pre-maxilla, synthesize new bone matrix for eruption ... The functions of osteoblasts are bone formation by synthesising the organic matrix of bone, cell to cell communication and ...
Zylberberg, L.; Laurin, M. (2011). "Analysis of fossil bone organic matrix by transmission electron microscopy". Comptes Rendus ... bone (main component of the organic part of bone) Type II: cartilage (main collagenous component of cartilage) Type III: ... In bone, entire collagen triple helices lie in a parallel, staggered array. 40 nm gaps between the ends of the tropocollagen ... Collagen is used in bone grafting as it has a triple helical structure, making it a very strong molecule. It is ideal for use ...
They received $100.000 for their Osteogenic Bone Matrix (OBM) innovation. Pires is a board member of the Licensing Executive ...
Zylberberg, L.; Laurin, M. (2011). "Analysis of fossil bone organic matrix by transmission electron microscopy". Comptes Rendus ... The use dinosaur bones as "dragon bones" has persisted in Traditional Chinese medicine into modern times, with Mid Cretaceous ... In medieval China, the fossil bones of ancient mammals including Homo erectus were often mistaken for "dragon bones" and used ... Bone. 52 (1): 414-23. doi:10.1016/j.bone.2012.10.010. PMID 23085295. Embery G, Milner AC, Waddington RJ, Hall RC, Langley ML, ...
Osteopontin is involved in mineralization in the extracellular matrices of bones and teeth. ...
... is an acidic extracellular matrix glycoprotein that plays a vital role in bone mineralization, cell-matrix ... Osteonectin is also detectable in osteoid, bone matrix proper, and dentin. Osteonectin has been localized in a variety of ... Osteonectin is a glycoprotein in the bone that binds calcium. It is secreted by osteoblasts during bone formation, initiating ... and regulation of the major noncollagenous matrix proteins of bone". Clinical Orthopaedics and Related Research (281): 275-94. ...
Sulfatases are essential for the correct composition of bone and cartilage matrix. Deficiencies in ARSE are associated with X- ... linked recessive chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development. GRCh38 ...
Extensive bone remodeling has occurred in the internal matrix of the rib. The medullary cavity, which houses the marrow, is ... On the outer surface of the bone, osteons have almost completely replaced the interior of the bone; the layered growth of the ... The supraoccipital bone, which forms the top portion of the back of the skull, is flat and nearly vertical, as is the case in ... Among the metacarpal bones of the hand, the second is curved, the third is straight, and the fourth is strongly curved. Like ...
She is investigating the best conditions for growing the matrix of bone. In 2015 she won the Medical Research Council Suffrage ... A role for prostacyclin in adaptive bone remodeling?". Journal of Bone and Mineral Research. 6 (12): 1345-1351. doi:10.1002/ ... "Funny bone". The Economist. Retrieved 2018-06-09. University, Keele. "MRC Suffrage Science Award 2015 for Professor Alicia El ... Lance (December 1991). "Loading‐related increases in prostaglandin production in cores of adult canine cancellous bone in vitro ...
The cell fusions provide the matrix for the regeneration of bone tissue. Maërl is also used as a food additive for cattle and ... Medical science now uses corallines in the preparation of dental bone implants. ...
Takeuchi Y, Kodama Y, Matsumoto T (Dec 1994). "Bone matrix decorin binds transforming growth factor-beta and enhances its ...
"The enhancement of bone regeneration by gene activated matrix encoding for platelet derived growth factor". Biomaterials. 35 (2 ... In experiments, it new bone fully covered skull wounds in test animals and stimulated growth in human bone marrow stromal cells ... A non-viral PDGF "bio patch" can regenerate missing or damaged bone by delivering DNA in a nano-sized particle directly into ... Repairing bone fractures, fixing craniofacial defects and improving dental implants are among potential uses. The patch employs ...
Enamel Matrix Protein These agents not only help improve wound healing but also stimulate regeneration of the lost bone, ... Rathe, F; Junker, R; Chesnutt, B. M.; Jansen, J. A. (2009). "The effect of enamel matrix derivative (Emdogain) on bone ... PGE2 upregulates bone resorption by osteoclasts and their levels are higher in patients with periodontal disease than in ... Growth Factors Bone Morphogenic Proteins Michael G. Newman; Henry Takei; Perry R. Klokkevold; Fermin A. Carranza (14 February ...
... is a bone-like matrix that is porous and yellow-hued material. It is made up, by weight, of 72% inorganic materials ( ... The innermost layer of dentin is known as predentin, and is the initial dentin matrix that is laid down prior to mineralization ... Matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) in mature human odontoblasts and pulp tissue. ... It is similar to osteoid in bone and is thickest when dentinogenesis is occurring. Secondary dentin (adventitious dentin) is ...
2004). "Dentin matrix protein 1 is expressed in human lung cancer". J. Bone Miner. Res. 18 (8): 1506-12. doi:10.1359/jbmr. ... 2004). "Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1". J. Biol. Chem. 279 (2): 980-6. ... 2006). "A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment". J. Biol. Chem. 281 (12 ... Dentin matrix acidic phosphoprotein 1 is a protein that in humans is encoded by the DMP1 gene. Dentin matrix acidic ...
This sealing zone becomes the site of osteoclast attachment to the bone matrix. Inhibition of bone resorption through drug ... Osteoclasts are large, multinucleated bone cells that conduct the process of bone resorption. In this remodeling process, ... Linder, S (March 2007). "The matrix corroded: podosomes and invadopodia in extracellular matrix degradation". Trends in Cell ... Upon initiation of bone resorption, the band of podosomes disassembles leaving behind a mesh primarily composed of F-actin ...
This matrix can be liquid or rigid. For example, blood contains plasma as its matrix and bone's matrix is rigid. Connective ... Blood, bone, tendon, ligament, adipose, and areolar tissues are examples of connective tissues. One method of classifying ... A tissue is an ensemble of similar cells and their extracellular matrix from the same origin that together carry out a specific ... Mineralized tissues are biological tissues that incorporate minerals into soft matrices. Such tissues may be found in both ...
... the margins of the bone can be seen there, still encased by matrix. The crest probably had a keratinous (horny) covering and ... the frontmost snout bones), frontal bones, parietal bones, and part of the supraoccipital bone. The premaxillae formed most of ... long from the tip of the premaxilla to the joint where the quadrate bone of the skull connected with the articular bone of the ... The ectopterygoid (bone on the side of the palate) had large, plate-like sides, and was well-developed compared to related ...
Flexible, bifurcating blood vessels and fibrous but elastic bone matrix tissue were recognized. In addition, microstructures ... Bucky also has a nearly complete set of gastralia, or belly ribs, and an ulna, or lower arm bone. As of now, 101 bones, or ... and shoulder bones that have all been measured to be larger and thicker with "Scotty" than the corresponding bones with "Sue". ... A piece of bone is missing at the rear, and the skull also bears a hole 1 inch wide, probably made by another Tyrannosaurus. ...
... is the organic extracellular matrix of bone, which is made of 95% collagen. It can be isolated by treating bones with ... The deproteinized bone residue left after the removal of ossein can be used to produce bone ash for the manufacture of bone ... Bones that are unsuitable for ossein production are carbonized to generate bone char. Bone mineral Bender, Arnold E. (2013). ... This substance is used in industry for the production of gelatin and bone glue. In the early 20th century, bones were found to ...
... but no matrix. The osteoclasts consume the trabecular bone that osteoblasts lay down and this front of reparative bone ... Hemosiderin deposition is not a distinctive feature of brown tumors; it may also be seen in giant cell tumors of the bone. ... It most commonly affects the maxilla and mandible, though any bone may be affected. Brown tumours are radiolucent on x-ray. ... The brown tumor is a bone lesion that arises in settings of excess osteoclast activity, such as hyperparathyroidism. They are a ...
Analysis of a fossil sample begins with demineralization of the bone/tooth mineral matrix. Trypsin is commonly used to digest ... is a bone and dentin protein involved in bone assembly, often used as a marker for the bone formation process. Preserved ... More advanced proteomic techniques have enabled the investigation of additional NCPs present in the bone extracellular matrix. ... in 10,000 year-old bison bone and a 53,000-year-old walrus bone, revealing phylogenetic reconstruction potential beyond the ...
August 2019). "Matrix remodeling associated 7 promotes differentiation of bone marrow mesenchymal stem cells toward osteoblasts ... "Entrez Gene: Matrix remodeling associated 7". Retrieved 2019-08-06. Zhou Z, Shen Y, Yin J, Xi F, Xu R, Lin D, et al. ( ... Matrix remodeling associated 7 is a protein that in humans is encoded by the MXRA7 gene. Loss-of-function studies performed in ... Wang Y (2020). "Matrix Remodeling Associated 7 (MXRA7): a Long-lost Member of the Non-kin MXRA Family". Chinese Journal of ...
They also do not ingest foreign materials and instead absorb bone matrix and minerals. Osteoclasts are typically associated ... Studies that observed that bone resorption could be restored by bone marrow and spleen transplants helped prove osteoclasts ... Osteoclasts are the most prominent examples of MGCs and are responsible for the resorption of bones in the body. Like other ... They function alongside osteoblasts to remodel and maintain the integrity of bones in the body. They also contribute to the ...
Coluzzi F, Mandatori I, Mattia C (September 2011). "Emerging therapies in metastatic bone pain". Expert Opin Emerg Drugs. 16 (3 ... In particular, abnormal interactions between epithelial cells and the extracellular matrix are associated with the over- ...
... and decreased bone mineral density, make its use for male acne impractical in most cases.[114][115][116] Pregnant and lactating ... The involvement of AP-1 in the aforementioned inflammatory cascade activates matrix metalloproteinases, which contribute to ...
collagen-containing extracellular matrix. العمليات الحيوية. • bone mineralization. • biomineral tissue development. • negative ...
"Journal of Bone and Mineral Research. 22 (8): 1245-1259. doi:10.1359/jbmr.070420. PMID 17456009.. ... Chondrocytes are only present in cartilage where they will produce cartilaginous matrix to maintain the structure. Sox9, L-Sox5 ... giving rise to either bone or cartilage respectively. Osteochondroprogenitor cells are important for bone formation and ... Brian Keith Hall (2005). Bones and cartilage: developmental and evolutionary skeletal biology. Academic Press. pp. 150-. ISBN ...
Chiropractors use x-ray radiography to examine the bone structure of a patient. ... Health Matrix Clevel. 19 (2): 493-537. PMID 19715143.. ... results of the Bone and Joint Decade 2000-2010 Task Force on ...
Cancer, bone fractures. Significant tests. screening tests, X-ray, CT, MRI, PET, bone scan, ultrasonography, mammography, ... or it may directly activate a matrix of solid-state detectors (DR-similar to a very large version of a CCD in a digital camera ... DEXA, or bone densitometry, is used primarily for osteoporosis tests. It is not projection radiography, as the X-rays are ... Usually the hip (head of the femur), lower back (lumbar spine), or heel (calcaneum) are imaged, and the bone density (amount of ...
extracellular matrix Reticular fibers. Form a scaffolding for other cells. Type III collagen. liver, bone marrow, and lymphatic ... Bind bones and other tissues to each other. Alpha polypeptide chains. tendon, ligament, skin, cornea, cartilage, bone, blood ... Special connective tissue consists of reticular connective tissue, adipose tissue, cartilage, bone, and blood.[8] Other kinds ... Both the ground substance and proteins (fibers) create the matrix for CT. Connective tissues are derived from the mesenchyme. ...
Both sets of bones connect the shoulder girdle to the skull. With the loss of these bones, tetrapods acquired a neck, allowing ... Water retention was now important, since it was no longer the living matrix, and could be lost easily to the environment. ... Bones and groups of bones were also consolidated and strengthened.[71]. In Carboniferous tetrapods, the neck joint (occiput) ... A notable feature of Tiktaalik is the absence of bones covering the gills. These bones would otherwise connect the shoulder ...
... bone can be exposed in the joint. Some additional examples of cartilage failure mechanisms include cellular matrix linkage ... The cells grow in self-organized spheroid matrices which are implanted via injected fluid or inserted tissue matrix. For years ... called matrix-associated autologous chondrocyte transplantation (MACT), grows the patient's cells in a 3D matrix of resorbable ... Autologous matrix-induced chondrogenesis, which is also known as AMIC, is a biological treatment option for articular cartilage ...
"90 Best Movies of the '90s, From 'The Silence of the Lambs' to 'The Matrix' (Photos)". TheWrap. Archived from the original on ... Bag of Bones (2011). *Big Driver (2014). *11.22.63 (2016). *"Chapter Thirty-One: A Night to Remember" (2018) ...
Increases strength of bones, teeth and connective tissues - Aids the production of collagen which is the foundational matrix of ... Foundation for strong healthy bones and teeth - majority of the calcium consumed as a child is deposited onto collagen bone ... matrix, sufficient calcium ensures strong collagen fibres supporting the bone and its growth (Deen & Hark, 2007). Assists in ... As a child the body requires iodine for brain and bone development. Fruit and vegetables grown in iodine rich soils provide the ...
This agent also causes respiratory tract lesions, bone marrow depression, and eye damage, the epithelial tissues of these ... bid-activated pathway that involves matrix metalloproteinase-12. J Biol Chem. 282 :7723-32. Pulichino AM, Wang IM, Caron A, ... bid-activated pathway that involves matrix metalloproteinase-12. J Biol Chem. 282 :7723-32. Pulichino AM, Wang IM, Caron A, ...
The matrix surrounds the cells of the body in an organized meshwork and functions as the glue that holds the cells of the body ... The bones themselves may be affected, resulting in short stature. In addition, pebbly, ivory-colored skin lesions may be found ... This matrix is made up of a variety of sugars and proteins and helps to form the architectural framework of the body. ... One of the parts of the extracellular matrix is a complex molecule called a proteoglycan. Like many components of the body, ...
... is a bone-like matrix that is porous and yellow-hued material. It is made up of 70% inorganic materials (mainly ... Cells and Extracellular Matrices of Dentin and Pulp: A Biological Basis For Repair and Tissue Engineering, M. Goldberg and A.J ... The innermost layer of dentin is known as predentin, and is the initial dentin matrix that is laid down prior to mineralisation ... Matrix metalloproteinases (MMPs) and their specific tissue inhibitors (TIMPs) in mature human odontoblasts and pulp tissue. ...
extracellular matrix. • cytosol. • cell nucleus. • neuron projection. • neuronal cell body. Biological process. • muscle organ ... Greally MT; Jewett T; Smith WL Jr.; Penick GD; Williamson RA (1993). "Lethal bone dysplasia in a fetus with manifestations of ... Mutations in the FLNB gene are involved in several lethal bone dysplasias, including boomerang dysplasia and atelosteogenesis ...
extracellular matrix. • integrin alpha4-beta1 complex. • EMILIN complex. Biological process. • cell adhesion. • cell-matrix ... extracellular matrix constituent conferring elasticity. • identical protein binding. • integrin binding involved in cell-matrix ... proteinaceous extracellular matrix. • extracellular region. • extracellular exosome. • extracellular space. • ... It is the best characterized member of the EMILIN family of extracellular matrix glycoproteins. ...
The fibrous connective tissue that connects bones to other bones and is also known as articular ligament, articular larua, ... In eukaryotes, the cytoskeletal matrix is a dynamic structure composed of three main proteins, which are capable of rapid ...
Pink cubic halite (NaCl; halide class) crystals on a nahcolite matrix (NaHCO3; a carbonate, and mineral form of sodium ... Minerals in this group are the main crystalline constituents of teeth and bones in vertebrates. The relatively abundant ... Perfect basal cleavage as seen in biotite (black), and good cleavage seen in the matrix (pink orthoclase). ...
Additionally, the extracellular matrix and dense outer layer of bacterial cells can protect the inner bacteria cells from ... Møller M; El Maghrabi R; Olesen N; Thomsen VØ (November 2004). "Safe inoculation of blood and bone marrow for liquid culture ... biofilms by adhering to surfaces on implanted devices such as catheters and prostheses and creating an extracellular matrix for ...
Hargraves M, Richmond H, Morton R. Presentation of two bone marrow components, the tart cell and the LE cell. Mayo Clin Proc ... CENP-F is a 367kDa protein from the nuclear matrix that associates with the kinetochore in late G2 phase during mitosis. CENP-A ... The LE cell was discovered in bone marrow in 1948 by Hargraves et al.[69] In 1957 Holborow et al. first demonstrated ANA using ...
The Erlitou culture may have evolved from the matrix of Longshan culture. Originally centered around Henan and Shanxi Province ... The discovery of writing in the form of oracle bones at Yinxu in Anyang definitively established the site as the last capital ...
This is followed by solos by banjo and saxophone, a stop time chorus featuring unison work by the reeds, trombone solo, and ... Matrix scheme. *MMM. *Petters Group Worldwide. *Pyramid schemes in Albania. *Reed Slatkin ...
The mesangium by light microscopy may be hypercellular and show increased deposition of extracellular matrix proteins. In terms ... but from the bone marrow. This, too, suggests an immune pathology rather than direct interference by outside agents. ...
A report of sixteen cases of Erb's palsy occurring in military cadets". The Journal of Bone and Joint Surgery. American Volume ...
... resulting in increased production of osteoclasts that may break down a person's bone matrix.[16] In states of hypocalcemia, ... Osteoporosis, a condition characterized by reduced bone mineral density and increased bone fragility. ... Deficiency impairs bone mineralization, leading to bone softening diseases such as rickets in children. It can also worsen ... causing overt bone disease from before birth and impairment of bone quality after birth.[9][14] ...
Techniques such as casting, stamping and moulding use an intermediate matrix containing the design to produce the work; many of ... The classic materials, with outstanding durability, are metal, especially bronze, stone and pottery, with wood, bone and antler ... The Swimming Reindeer of about 13,000 years ago is one of the finest of a number of Magdalenian carvings in bone or antler of ... and bone-flutes, as well as three-dimensional figurines.[20][21] ...
"Ceramic Matrix Composites - From Space to Earth: The Move from Prototype to Serial Production". Ceramic Engineering and Science ... "Fixation of carbon fibre-reinforced carbon composite implanted into bone". Journal of Materials Science Materials in Medicine. ... depending on how the fibre scaffold is laid up and the quality/density of the matrix filler.[citation needed] ... is a composite material consisting of carbon fiber reinforcement in a matrix of graphite. It was developed for the nose cones ...
Moreover, it is an important cause of bone and joint infections, and this disease manifestation is reported to be increasing. ... Although many laboratories currently identify bacteria by mass-spectrometry (Matrix Assisted Laser Desorption/ionization Time ...
Janis LS, Cassidy RM, Kromer LF (1999). "Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the ...
bone matrix synonyms, bone matrix pronunciation, bone matrix translation, English dictionary definition of bone matrix. n. A ... structural unit of bone consisting of a haversian canal and corresponding lamellae of compact bone. Also called haversian ... Bone matrix - definition of bone matrix by The Free Dictionary https://www.thefreedictionary.com/bone+matrix ... demineralized bone matrix allografts, and bone graft substitutes - bone morphogenic proteins and synthetic bone graft extenders ...
The matrix is manufactured from protein-extracted bone powder treated with certain swelling agents to increase its surface area ... The matrix may be combined with osteogenic protein to induce reliably and reproducibly endochondral bone formation. It also can ... Disclosed is a matrix material for implantation in a mammalian host comprising biocompatible mineral-free type I bone collagen ... in rat bone matrix over that of bovine bone matrix. It has been discovered that increasing porosity helps entrap protein, and ...
... Yoshinobu Uchihara,1 Manabu Akahane,2 Takamasa ... C. Maniatopoulos, J. Sodek, and A. H. Melcher, "Bone formation in vitro by stromal cells obtained from bone marrow of young ... "Osteogenic matrix sheet-cell transplantation using osteoblastic cell sheet resulted in bone formation without scaffold at an ... "Bone marrow-derived mesenchymal cells can rescue osteogenic capacity of devitalized autologous bone," Journal of Tissue ...
... Andreas O. Parashis,1,2 Charalampos J. ... and histological outcomes following use of a bilayer xenogeneic collagen matrix (XCM) in combination with freeze-dried bone ... The XCM was adapted to cover the defect and 2-3 mm of adjacent bone and flaps were repositioned. Healing was uneventful in all ... Exposed matrix portions were slowly vascularized and replaced by mature keratinized tissue within 2-3 months. Radiographic and ...
Make sure you apply the bones offset matrix to the bone before you generate a bounding area around it. Then apply the bones ... The offset matrix should orientate the bone so that it is straight.. After that, just apply each bones final transform matrix ... m having is with the matrix math to orient that geometry at the position of the bones orientation. Having a few matrices to ... Matrix Math - Bone Hierachy Orientation By Carandiru, June 5, 2004. in Math and Physics ...
... containing protease inhibitors to solubilize putative inductive molecules in the bone matrix. Extraction of bone matrix with ... HCl-treated bone matrix and then implanted, new bone was induced. These observations demonstrate the dissociative extraction ... The various reconstituted matrices were bioassayed for bone inductive potential by quantitation of alkaline phosphatase ... Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. T K ...
... similar to what we find in natural bone --while the bone matrix formed by the static samples was thin and brittle." Mikos said ... bone cells called "osteoblasts" and several growth factors that osteoblasts use to build the mineralized matrix of bones -- but ... This photograph from an electron microscope shows a pore that has formed in a 3-D bony matrix. Bone-forming cells are clearly ... Rice bioengineers develop method to grow 3-D bone matrix. 04.10.2002 ...
I believe all Im looking for is the bind pose matrix for each individual bone in my armature. There are a few options in the ... armature[x].bone[x].matrix. armature[x].bone[x].matrix_local. and in the posebone. bone.matrix. bone.matrix_basis. bone.matrix_ ... Exporting bone bind pose matrices Hello all,. Its my first time using these forums, so please correct me if Im putting this ... I believe the matrix in question Im looking for is 4x4, and should be connected to the bone data in the armature. Ive tried ...
The present invention provides effective new methods and materials for maxillofacial bone augmentation, particularly alveolar ... Biocompatible Matrix Comprising β-TCP and Collagen In some embodiments, a biocompatible matrix can comprise a β-TCP bone ... Bone Scaffolding Comprising β-Tricalcium Phosphate A bone scaffolding material for use as a biocompatible matrix can comprise β ... Bone Scaffolding Material A biocompatible matrix, according to embodiments of the present invention, comprises a bone ...
Osteocalcin is an abundant Ca2+-binding protein indigenous to the organic matrix of bone, dentin, and possibly other ... Osteocalcin: the vitamin K-dependent Ca2+-binding protein of bone matrix Haemostasis. 1986;16(3-4):258-72. doi: 10.1159/ ... Osteocalcin is an abundant Ca2+-binding protein indigenous to the organic matrix of bone, dentin, and possibly other ... The vitamin-K-dependent biosynthesis of osteocalcin occurs in bone, and the protein is not homologous to the Gla-containing ...
FUENTES, Ramón et al. The Behavior of Demineralized Bone Matrix (DBM) in Post-Extraction Sockets. Int. J. Morphol. [online]. ... Autogenous bone grafts are considered to be the gold standard in bone regeneration because of their osteogenic activity; ... A very mature bone was observed at 6 months after DBM graft placement in the sockets, showing it to be a good alternative as ...
... is designed to be injected into damaged bone, which then harde ... Injectable Matrix to Help Regrow Damaged Bones. December 8th, ... is designed to be injected into damaged bone, which then hardens into a strong scaffold as a medium for new bone tissue to grow ... In more challenging applications, stem cells, matrix and/or growth factors must be provided within the 3D template. The ... When a tissue develops or repairs itself a "regenerative niche" is formed comprising cells, 3D template, extracellular matrix ...
In the second application we mapped the calcium content in a human bone matrix in close proximity to osteocyte lacunae ( ... perilacunar matrix). A concurrently acquired ptychographic image was used to remove the mass-thickness effect from the raw ... calcium distribution allowed then to observe a locally lower degree of mineralization of the perilacunar matrix. ... Bone Matrix Mineralization. Pathologies of the skeleton are among the most common morbidities worldwide. Age-related bone loss ...
2 bones in total) in global coordinates. Ok. these points p1, p2, p3 are drawn in global coordinates (see values X,Y). Now I ... Matrix mx_parent_global = pnt[i-1].globalMatrix; // parent joint global matrix // Now I need to work out the local matrix for ... Global to local transformation - matrices, bones GameDev.net needs your input - and you could win a $25 Amazon gift card! Click ... Global to local transformation - matrices, bones By papa, September 21, 2004. in Math and Physics ...
... announced the release of its CONFORM SHEET demineralized cancellous bone scaffold thats designed for implantation during ... CONFORM SHEET Bone Matrix for Spinal Fusions Now in U.S.. January 6th, 2014 Medgadget Editors Neurosurgery, Orthopedic Surgery ... When combined with bone marrow aspirate, CONFORM SHEET becomes osteogenic.. "CONFORM SHEET has excellent handling ... It is compressible for precise placement, where it can then expand to fill the bone void," said Khalid Sethi, MD, FACS, Chief ...
J Bone Miner Res. 1999 Nov;14(11):1902-8. Research Support, Non-U.S. Govt; Research Support, U.S. Govt, P.H.S. ... Determination of bone markers in pycnodysostosis: effects of cathepsin K deficiency on bone matrix degradation.. Nishi Y1, ... of organic bone matrix. To determine the in vivo effects of cathepsin K mutations on bone metabolism in general and osteoclast- ... and is secreted into the subosteoclastic space where bone matrix is degraded. In vitro studies revealed that mutant cathepsin K ...
... pose.bones["leg1.R"] armaturematrix = Matrix(Object.Get("Armature").matrixWorld) ws_bindposematrix = Matrix(bone.matrix[" ... a bones world space bind pose matrix. - a bones world space animation frame matrix. i think i know how to calculate ... pose_mat = Matrix(pose_bone.poseMatrix). pose_mat.invert(). to avoid inverting the matrix. (This behavior is consistent with ... This is the bone transformation trick; theyre hierarchical so each bone(b). is in the coord system of bone(b-1):. arm_mat(b)= ...
Demineralized bone matrix (DBM) is allograft bone that has had the inorganic mineral removed, leaving behind the organic " ... It was first discovered by Marshall Urist in 1965 that the removal of the bone mineral exposes more biologically active bone ... Graham, S.M., et al., Biological therapy of bone defects: the immunology of bone allo-transplantation. Expert Opinion on ... The success of a bone graft is determined by its ability to recruit host cells to the site of the graft and modulate their ...
Right now I can get an armature and its bones, but when I print the bone matrix, it seems to be ei… ... Right now I can get an armature and its bones, but when I print the bone matrix, it seems to be either for the start frame, or ... Actually I found out how to get the matrix per frame, but how to I change the active frame in the timeline? ...
Immediate loading may be preferable in order to ensure robust bone formation in vivo. The use of a secondary ECM carrier ... with or without an extracellular matrix-based seeding suspension, on cell engraftment and osteogenesis. When quantitatively ... Cell-based tissue engineering can be used to replace missing or damaged bone, but the optimal methods for delivering ...
Using a rat ectopic bone formation model, we have injected rhBMP-2 into a collagen matrix with or without a bifunctional BMP-2 ... and bone maturity at the site of injection. Our results suggest that bifunctional peptides that can simultaneously bind to a ... collagen peptide (BC-1). The presence of BC-1 significantly increased osteogenic cellular activity, the area of bone formed, ... tissue engineering approaches are being developed that combine growth factors such as Bone Morphogenetic Proteins (BMP) with ...
... noncollagenous proteins of the organic matrix of chicken bone by Sephadex G-100 molecular sieving has revealed that the ... γ-carboxyglutamic acid-containing peptide of bone matrix.. Key words. Phosphoprotein Bone 31P-NMR Phosphoserine ... Lee, S. L., Glimcher, M. J.: Bone matrix phosphoproteins from adult avian metatarsals, J. Cell Biol.83:464a, 1979Google Scholar ... Fractionation of the EDTA-soluble, noncollagenous proteins of the organic matrix of chicken bone by Sephadex G-100 molecular ...
... extracellular matrix protein binding, extracellular matrix structural constituent, negative regulation of bone mineralization, ... Matrix extracellular phosphoglycoprotein with ASARM motif (bone)Imported. ,p>Information which has been imported from another ... tr,Q8K4L6,Q8K4L6_MOUSE Matrix extracellular phosphoglycoprotein with ASARM motif (bone) OS=Mus musculus GN=Mepe PE=2 SV=1 ... negative regulation of bone mineralization Source: MGI ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for ...
Home , October 2011 - Volume - Issue , REDUCED DOSE OF RHBMP‐2 WITH DEMINERALIZED BONE MATRIX‐BASED... ... REDUCED DOSE OF RHBMP‐2 WITH DEMINERALIZED BONE MATRIX‐BASED PRODUCT FOR SPINAL FUSION: GP101.. Delamarter, Rick MD; Kropf, ... REDUCED DOSE OF RHBMP‐2 WITH DEMINERALIZED BONE MATRIX‐BASED PRODUCT FOR SPINAL FUSION: GP101. ... As is clinically practice, autogeneous bone added to the DBM‐based product also enhanced rapid bone formation. ...
... clearance of its Collagen Bone Healing Protective Sheet intended for use in orthopedic applications involving bone repair. ... Collagen Matrix is pleased to announce that it has received FDAs 510(k) ... is used to maintain the relative position of weak bony tissue such as bone grafts, bone graft substitutes, or bone fragments ... Collagen Matrix is pleased to announce that it has received FDAs 510(k) clearance of its Collagen Bone Healing Protective ...
... vivo was successfully fabricated by simple subcutaneous injection of chitosan and GP solutions with demineralized bone matrix ( ... we developed an injectable carrier for demineralized bone matrix (DBM) which consists of chitosan and glycerol phosphate (GP). ... In this study, we developed an injectable carrier for demineralized bone matrix (DBM) which consists of chitosan and glycerol ... Y. H. Kim et al., "Injectable Chitosan Carrier for Demineralized Bone Matrix", Key Engineering Materials, Vols. 342-343, pp. ...
What is bone matrix? Meaning of bone matrix as a finance term. What does bone matrix mean in finance? ... Definition of bone matrix in the Financial Dictionary - by Free online English dictionary and encyclopedia. ... Bone matrix financial definition of bone matrix https://financial-dictionary.thefreedictionary.com/bone+matrix ... matrix. (redirected from bone matrix). Also found in: Dictionary, Thesaurus, Medical, Legal, Encyclopedia. Fig. 58 Matrix. The ...
The contribution of the mineral phase to bones mechanical properties has dominated scientific thinking. Collagens role has ... Bone is a two-phase porous composite material comprised primarily of collagen and mineral, which together provide its ... The Contribution of the Organic Matrix to Bones Material Properties Bone. 2002 Jul;31(1):8-11. doi: 10.1016/s8756-3282(02) ... it may have a profound effect on bone fragility. Collagen changes that occur with age and reduce bones toughness may be an ...
Endochondral bone formation in gelatin methacrylamide hydrogel with embedded cartilage-derived matrix particles.. [Jetze Visser ... This work offers a new avenue for the engineering of relevant-size bone grafts, by the formation of endochondral bone within a ... The natural process of endochondral bone formation in the growing skeletal system is increasingly inspiring the field of bone ... In a subcutaneous rat model, this template was subsequently remodeled into mineralized bone tissue, including bone-marrow ...
The extracellular matrix of bone. For decades, attention devoted to the biology of the extracellular matrix (ECM) of bone has ... Creation of a scaffold in de novo bone formation. In physiology, bone formation occurs a) on preexisting bone surfaces, or b) ... Bone forms on the surface of the HAC material, and a distinct layer of BSP-enriched matrix marks the HAC/bone interface (B, D, ... Deposition of the first bone matrix at any site of de novo bone formation takes place between rows of cells facing each other ( ...
  • To determine the in vivo effects of cathepsin K mutations on bone metabolism in general and osteoclast-mediated bone resorption specifically, several bone metabolism markers were assayed in serum and urine from seven Pycno patients. (nih.gov)
  • TGF-[beta] is stored in the mineralized bone matrix in its latent form and can be activated by exposure to a low pH environment similar to that generated by the osteoclast during bone resorption. (thefreedictionary.com)
  • Likewise, the manner in which biomaterial scaffolds are 'resorbed' by osteoclasts in vitro and in vivo highlights more complex scenarios than predicted from knowledge of physiological bone resorption per se . (scielo.br)
  • rhBMP-2/Calcium Phosphate Matrix Induces Bone Formation While Limiting Transient Bone Resorption in a Nonhuman Primate Core Defect Model. (biomedsearch.com)
  • BACKGROUND: Transient bone resorption limits the use of recombinant human bone morphogenetic protein-2 (rhBMP-2)/absorbable collagen sponge in metaphyseal bone. (biomedsearch.com)
  • The purpose of the present study was to evaluate the efficacy of rhBMP-2/calcium phosphate matrix (CPM) to induce bone formation while limiting transient bone resorption in nonhuman primate core defects. (biomedsearch.com)
  • Transient bone resorption was only observed in the distal femoral sites treated with 4.5 mg/mL of rhBMP-2/CPM at two weeks. (biomedsearch.com)
  • CONCLUSIONS: Treatment of nonhuman primate metaphyseal core defects with 1.5 to 3.0-mg/mL rhBMP-2/CPM resulted in bone formation without transient bone resorption. (biomedsearch.com)
  • Our data demonstrate considerable differences in protein composition of flat and long bones and strongly suggest functional differences in formation, resorption, and mechanical properties of these bone types. (uva.nl)
  • On the other hand, bone-resorption in the lower metaphysis has been thoroughly investigated. (avhandlingar.se)
  • Since bone and cartilage are tissues with different composition, our hypothesis was that the resorption mechanisms may also be separate. (avhandlingar.se)
  • In the present study, Sprague-Dawley rats were used to investigate some aspects of matrix resorption in calcified cartilage compared with bone. (avhandlingar.se)
  • Since they all contain an Arg-Gly-Asp (RGD) sequence, they may bind to integrin receptors on cell surfaces, making them potentially active in cell-matrix adhesion, as an initial step in the resorption sequence. (avhandlingar.se)
  • In summary we showed that chondroclasts and osteoclasts were different regarding some characteristic morphometric features, indicating differences in resorption mechanisms between bone and cartilage. (avhandlingar.se)
  • Furthermore, we identified a previously unrecognized structure at the cell-matrix border with features of both ruffled borders and clear zones, ie the traditional resorption characteristics. (avhandlingar.se)
  • Restitution of traditional ultrastructural resorption characteristics, at 48 hours after introduction of normal food, coincides largely with secretion of cathepsin K to the matrix surface, rendering this enzyme suitable as a marker for active resorption. (avhandlingar.se)
  • The cells responsible for bone resorption are? (coursehero.com)
  • This result suggest the possibility that osteocyte play important role for bone resorption by producing osteopontin. (nii.ac.jp)
  • The absence of bone resorption to the loading of pressure force was observed in osteopontin nockout mice also demonstrate that osteopontin is a key molecule of bone remodeling. (nii.ac.jp)
  • Histological studies on mouse femurs with metastasis of breast cancer MDA-MB-231 cells revealed that the osteoclasts in the metastatic bone were abnormally large and they generated resorption cavities that are irregular both in size and in shape. (go.jp)
  • Stratified resorption providing structural support throughout the regenerative process and maintaining bone volume. (opnews.com)
  • While the fast resorption of beta-TCP quickly offers space for new bone formation, the HA component provides volume stability for an extended time period, ensuring treatment success also in case of a two-stage procedure (delayed implantation). (botiss-indications.com)
  • The latter pathway may be stimulated by substances released from the osteoclast or from the bone matrix during resorption. (corenatherapeutics.com)
  • Bone lining cells functions are not completely understood, but it has been shown that these cells prevent the direct interaction between osteoclasts and bone matrix, when bone resorption should not occur, and also participate in osteoclast differentiation, producing osteoprotegerin (OPG) and the receptor activator of nuclear factor kappa-B ligand (RANKL) [14, 53]. (corenatherapeutics.com)
  • Fortibone® is specifically designed to stimulate osteoblast activity, slow bone resorption and improve collagen production within the extracellular matrix of bone tissue. (cytomatrix.ca)
  • This 360-degree animation depicts bone resorption at the cellular level. (nucleusmedicalmedia.com)
  • Most drugs available for the treatment of osteoporosis are anti-resorptives, which slow the course of bone resorption during bone remodeling but do not promote new bone growth. (technologypublisher.com)
  • 1 However, this is not usually the case due to postextraction trauma, bone resorption, or periodontal defects. (allenpress.com)
  • However, TCP cements have a slower resorption rate than bone and are usually too dense to allow bone tissue to grow into the defect in a limited period of time. (allenpress.com)
  • osteoclasts are involved in the resorption of bone tissue. (wikipedia.org)
  • Meanwhile, the ALPL-expressing cells produced on average more than twice as much bone matrix (and as much as nine times more in some trials) during three weeks of subsequent cultivation than a similarsized population of unsorted adipose tissue cells and almost four times more bone matrix than cells that don't express ALPL. (thefreedictionary.com)
  • Scaffold-free cell sheet injection results in bone formation," Journal of Tissue Engineering and Regenerative Medicine , vol. 4, no. 5, pp. 404-411, 2010. (hindawi.com)
  • Bone marrow-derived mesenchymal cells can rescue osteogenic capacity of devitalized autologous bone," Journal of Tissue Engineering and Regenerative Medicine , vol. 2, no. 1, pp. 61-68, 2008. (hindawi.com)
  • The long-term outcome following the use of frozen autograft treated with liquid nitrogen in the management of bone and soft-tissue sarcomas," The Bone & Joint Journal , vol. 96, no. 4, pp. 555-561, 2014. (hindawi.com)
  • Exposed matrix portions were slowly vascularized and replaced by mature keratinized tissue within 2-3 months. (hindawi.com)
  • Tissue engineering researchers in Rice s J.W. Cox Laboratory for Biomedical Engineering have developed a new technique that allows bone-forming cells to build a porous, 3-D bony matrix that s structurally similar to natural bone. (innovations-report.com)
  • One of the greatest challenges tissue engineers face in growing bone in the laboratory is recreating the conditions that occur inside the body. (innovations-report.com)
  • Tissue engineers at Rice placed bone marrow-derived osteoblasts from rats into centimeter-wide plexiglass chambers containing a thin stack of titanium fiber mesh. (innovations-report.com)
  • Ultimately, however, artificial bone could be substituted for donor tissue or surgical implants made of synthetic materials. (innovations-report.com)
  • A new material developed by the University of Nottingham and RegenTec , a university spinoff, is designed to be injected into damaged bone, which then hardens into a strong scaffold as a medium for new bone tissue to grow over. (medgadget.com)
  • When a tissue develops or repairs itself a "regenerative niche" is formed comprising cells, 3D template, extracellular matrix and growth factors. (medgadget.com)
  • In simple applications the cells, extracellular matrix and growth factors are provided by the patient's own tissue neighbouring the repair site. (medgadget.com)
  • DePuy Synthes , part of J&J, announced the release of its CONFORM SHEET demineralized cancellous bone scaffold that's designed for implantation during spinal fusion procedures to promote the growth of the patient's own bone tissue in place of the product. (medgadget.com)
  • The material is prepared by the Musculoskeletal Transplant Foundation (MTF) to both provide guidance for tissue growth and to promote undifferentiated stem cells to turn into bone. (medgadget.com)
  • The Collagen Bone Healing Protective Sheet is used to maintain the relative position of weak bony tissue such as bone grafts, bone graft substitutes, or bone fragments from comminuted fractures. (fdanews.com)
  • This novel nanocomposite would be a promising material for bone tissue engineering. (scientific.net)
  • The natural process of endochondral bone formation in the growing skeletal system is increasingly inspiring the field of bone tissue engineering. (sigmaaldrich.com)
  • In a subcutaneous rat model, this template was subsequently remodeled into mineralized bone tissue, including bone-marrow cavities. (sigmaaldrich.com)
  • The use of mineralized scaffolds for guiding bone tissue engineering has revealed unexpected manners in which the scaffold and cells interact with each other, so that a complex interplay of integration and disintegration of the scaffold ultimately results in efficient and desirable, although unpredictable, effects. (scielo.br)
  • Investigation of novel biomaterials for bone engineering represents an essential area for the design of tissue engineering strategies. (scielo.br)
  • Originally, the driving idea was that one or more protein species produced in bone but not in other connective tissues would act as tissue-specific inducers, nucleators and regulators of mineral deposition. (scielo.br)
  • Given the ubiquitous nature of the major collagen species in bone, collagen type I, the search for noncollagenous components endowed with the 'King Mida's touch' which would turn tissue into stone, focused mostly on noncollagenous components. (scielo.br)
  • This clinical trial evaluated the effectiveness of Trinity Evolution, an allograft (donated tissue) made up of stem cells, bone growth factors, and a matrix for the bone formation. (spinerf.org)
  • ViviGen and ViviGen Formable are Human Cells, Tissues, and Cellular and Tissue-based Products (HCT/Ps) comprised of cryopreserved, viable cells within a cortical cancellous bone matrix and demineralized bone. (medindia.net)
  • Both precursors are utilized in the synthesis of organic matrix by bone tissue. (portlandpress.com)
  • The latter contains a glycoprotein of α-mobility that appears to be concentrated specifically in bone tissue and which is present also in plasma. (portlandpress.com)
  • In one embodiment, a series of RF pulses used to suppress fluid in the bone marrow spaces, particularly in cancellous bone tissue, is combined with solid state projection reconstruction magnetic resonance imaging (MRI) to provide a three-dimensional image of a bone in which the dominant signal arises substantially from solid organic bone matrix. (google.com)
  • The treatment in this case is conditioned to the primary stability defined as the absence of implant mobility once insert in the bone tissue [ 2 ]. (alliedacademies.org)
  • Methods of tissue engineering present an alternative to established procedures by in vitro assembly of bone implants that can be equipped with vascular structures for enhanced regeneration potential. (fraunhofer.de)
  • Successful homing to the target tissue, such as bone marrow, implies that MSC are able to extravasate after systemic administration. (haematologica.org)
  • However, over the past few years, several groups have reported other sources of MSC including umbilical cord blood, 12 umbilical vein, 13 peripheral blood, 14 non-hematopoietic bone marrow, 15 adipose tissue 16 and the post-partum placenta. (haematologica.org)
  • By using a model system of transplanting tumors into an irradiated normal tissue to prevent angiogenesis, we found that tumors were unable to grow in matrix metalloproteinase-9 ( MMP-9 ) knockout mice, but tumor growth could be restored by transplantation of wild-type BM. (pubmedcentralcanada.ca)
  • Tissue-engineered intervertebral discs (IVDs) utilizing decellularized extracellular matrix (ECM) could be an option for the reconstruction of impaired IVDs due to degeneration or injury. (figshare.com)
  • Over the last decade there have been increasing efforts to develop adequate 3D scaffolds for bone tissue engineering from bioactive ceramics with 3D printing emerging as a promising technology. (scientific.net)
  • The overall objective of the present study was to generate a tissue engineered synthetic bone graft with homogenously distributed osteoblasts and mineralizing bone matrix in vitro , thereby mimicking the advantageous properties of autogenous bone grafts and facilitating usage for reconstructing segmental discontinuity defects in vivo . (scientific.net)
  • The amount of cells and extracellular matrix formed and osteogenic marker expression were evaluated using hard tissue histology, immunohistochemical and histomorphometric analysis. (scientific.net)
  • In conclusion, RPS displayed superior mechanical and biological properties and facilitated generating a tissue engineered synthetic bone graft in vitro , which mimics the advantageous properties of autogenous bone grafts, by containing homogenously distributed terminally differentiated osteoblasts and mineralizing bone matrix and therefore is suitable for subsequent in vivo implantation for regenerating segmental discontinuity bone defects. (scientific.net)
  • The overall goal of this thesis is to quantify the osteoinductivity of the ECM produced by human amniotic fluid stem cells (AFS cells), compare it to that of human mesenchymal stem cells (MSC), and assess its potential for use in bone tissue engineering therapies. (gatech.edu)
  • A series of in vitro studies were performed to evaluate the characteristics of the ECM relevant to a bone tissue engineering therapy. (gatech.edu)
  • Osteocel processing begins with the recovery of strictly screened and tested donor tissue and results in a cellular allograft that retains its native bone-forming cell population. (lifemapsc.com)
  • We therefore established an in vitro engineered bone marrow tissue model that incorporates hMSCs and BM-ECM to facilitate mechanistic studies of prostate cancer cell survival in androgen-depleted media in response to paracrine factors and BM-ECM. (strath.ac.uk)
  • Head Investigator found that osteocytes, the cell types that embedded in bone matrix, produce osteopontin abundantly when mechanical stress is loaded to bone tissue. (nii.ac.jp)
  • Breast cancer is highly metastatic to bone tissue and causes osteolytic lesions through osteoclast activation. (go.jp)
  • To the best of our knowledge, this is the first report demonstrating that osteolytic bone metastasis induces the disruption of bone matrix alignment, which determines the mechanical function of bone in both intact and diseased bone tissue. (go.jp)
  • Understanding the bone matrix collagen assembly may help to explain how increased ratio of type V to type I collagen in osteogenesis imperfecta patients may impair structural integrity of the bone tissue and contribute to mechanical weakness. (elsevier.com)
  • In trials, MCHC has greatly benefitted those afflicted with osteomalacia (a painful bone tissue characterised by a gradual softening and bending of the bones). (nutriplusdirect.com)
  • When used with teenage boys suffering from idiopathic juvenile osteoporosis, MCHC stopped the atrophy of skeletal tissue and subsequent bone loss. (nutriplusdirect.com)
  • Enhanced differentiation of human embryonic stem cells on extracellular matrix-containing osteomimetic scaffolds for bone tissue engineering. (semanticscholar.org)
  • Pluripotent stem cells as a source of osteoblasts for bone tissue regeneration. (semanticscholar.org)
  • Bone tissue formation from human embryonic stem cells in vivo. (semanticscholar.org)
  • There are two types of bone tissue: compact and spongy. (corenatherapeutics.com)
  • Bones are organs that consist primarily of bone tissue, also called osseous tissue. (corenatherapeutics.com)
  • Bones are composed of two types of tissue: 1. (corenatherapeutics.com)
  • The extracellular matrix can be thought of as a suspension of macromolecules that supports everything from local tissue growth to the maintenance of an entire organ.These molecules are all secretions made by neighboring cells. (corenatherapeutics.com)
  • Compact Bone Tissue. (corenatherapeutics.com)
  • Bone allografts are influenced by the same immunologic factors as other tissue grafts. (corenatherapeutics.com)
  • Bone is a form of connective tissue found in the body, composed largely of hardened hydroxyapatite-containing collagen. (corenatherapeutics.com)
  • The combination of flexible collagen and hard mineral crystals makes bone tissue hard without making it brittle. (corenatherapeutics.com)
  • Biology) the intercellular substance of bone, cartilage, connective tissue, etc. is also believed that osteocytes are important in the transla- It makes up around 80 percent of adult bone mass. (corenatherapeutics.com)
  • Osseous Tissue: Bone Matrix and Cells Bone Matrix Osseous tissue is a connective tissue and like all connective tissues contains relatively few cells and large amounts of extracellular matrix. (corenatherapeutics.com)
  • The defect is filled with a bone graft material (allogeneic-, xenogeneic- or alloplastic bone substitute materials) that serves as a scaffold for ingrowth of bone forming cells (osteoconduction) and blood vessels, and prevents collapse of the overlying membrane and soft tissue. (botiss-indications.com)
  • The membrane acts as a barrier agains ingrowth of fast proliferating connective tissue cells, hence, giving the bone forming cells time and space for the osseous regeneration of the defect. (botiss-indications.com)
  • An osteocyte, a star-shaped type of bone cell, is the most commonly found cell in mature bone tissue, and can live as long as the organism itself. (corenatherapeutics.com)
  • Although specific collagen peptides can have powerful and beneficial effects on skeletal tissue as a solo therapy, optimal bone health requires much more. (cytomatrix.ca)
  • Two types of bone tissue are distinguished: bundle bone (primary bone) and compact bone (secondary bone). (aramram.tv)
  • Bone contains 100s of extracellular matrix (ECM) proteins and the ECM of the various bone tissue compartments plays essential roles directing the remodeling of bone through the coupled activity of osteoclasts (which resorb bone) and osteoblasts (which produce new bone). (aramram.tv)
  • Although the mechanism of action by which extracellular matrix promotes constructive remodeling of tissue is still unknown, researchers now believe that Matrix-bound nanovesicles (MBVs) are a key player in the healing process. (aramram.tv)
  • Bone is a modified form of connective tissue which is made of extracellular matrix, cells and fibers. (aramram.tv)
  • From: Comparative Biology of the Normal Lung (Second Edition), 2015 Extracellular matrix has been found to cause regrowth and healing of tissue. (aramram.tv)
  • a potential new scaffold-free material for bone tissue engineering. (aramram.tv)
  • An in vitro assessment of a cell-containing collagenous extracellular matrix-like scaffold for bone tissue engineering. (aramram.tv)
  • Bone tissue mainly consists of bone cells (osteoblasts, osteocytes, and osteoclasts) and a mineralized extracellular matrix that is primarily made up of collagen fibrils and hydroxyapatite crystals. (aramram.tv)
  • Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. (aramram.tv)
  • It is indicated for use in oral surgical applications involving bone repair such as augmentation or reconstructive treatment of the alveolar ridge and for the filling of periodontal defects in conjunction with products intended for Guided Tissue Regeneration and Guided Bone Regeneration. (ddsgadget.com)
  • This second volume serves as a valuable reference to practicing odontologists, biology and biomaterials scientists and tissue engineers interested in protein research related to tooth and bone formation. (benthambooks.com)
  • By mass, osseous tissue matrix consists of 1/3rd collagen fibers and 2/3rds calcium phosphate salt. (legacyharbourhotel.com)
  • Guided bone regeneration (GBR) is a well-established method to exclude soft-tissue cells by means of barrier membranes. (allenpress.com)
  • Bone tissue ECM consists of collagen, elastic, and reticular fibers. (devourdeals.com)
  • Collagen (/ ˈ k ɒ l ə dʒ ɪ n /) is the main structural protein in the extracellular matrix found in the body's various connective tissues.As the main component of connective tissue, it is the most abundant protein in mammals, making up from 25% to 35% of the whole-body protein content. (devourdeals.com)
  • Mesenchyme tissue differentiates into chondroblasts and begins secreting the molecules that form the extracellular matrix (ECM). (devourdeals.com)
  • A bone is a rigid tissue that constitutes part of the vertebrate skeleton in animals. (wikipedia.org)
  • Bone tissue (osseous tissue) is a hard tissue, a type of specialized connective tissue. (wikipedia.org)
  • Bone tissue is made up of different types of bone cells. (wikipedia.org)
  • The mineralized matrix of bone tissue has an organic component of mainly collagen called ossein and an inorganic component of bone mineral made up of various salts. (wikipedia.org)
  • Bone tissue is a mineralized tissue of two types, cortical bone and cancellous bone. (wikipedia.org)
  • Within any single bone, the tissue is woven into two main patterns, known as cortical and cancellous bone, and each with different appearance and characteristics. (wikipedia.org)
  • Cancellous bone, also called trabecular or spongy bone, is the internal tissue of the skeletal bone and is an open cell porous network. (wikipedia.org)
  • The bone grafts and bone grafts substitutes market report provides market size estimates (Revenue USD million - 2013 to 2020) for key market segments based on product type (demineralized bone matrix allografts, and bone graft substitutes - bone morphogenic proteins and synthetic bone graft extenders) and its medical applications (craniomaxilofacial, dental, foot and ankle, joint reconstruction, long bone, and spinal fusion), and forecasts growth trends (CAGR% - 2016 to 2020). (thefreedictionary.com)
  • In addition to its effects on cell growth and migration, TGF-[beta] also promotes the synthesis of bone matrix proteins by primary and transformed osteoblasts. (thefreedictionary.com)
  • The vitamin-K-dependent biosynthesis of osteocalcin occurs in bone, and the protein is not homologous to the Gla-containing regions of known vitamin-K-dependent blood coagulation proteins. (nih.gov)
  • Through a unique demineralization process, bone morphogenic proteins (BMPs) are exposed, providing CONFORM SHEET its osteoinductive properties, while the cancellous structure of the scaffold provides osteoconductive characteristics. (medgadget.com)
  • In vitro studies revealed that mutant cathepsin K proteins causing Pycno did not degrade type I collagen, the protein that constitutes 95% of organic bone matrix. (nih.gov)
  • It was first discovered by Marshall Urist in 1965 that the removal of the bone mineral exposes more biologically active bone morphogenetic proteins. (wikipedia.org)
  • Fractionation of the EDTA-soluble, noncollagenous proteins of the organic matrix of chicken bone by Sephadex G-100 molecular sieving has revealed that the majority of the organic phosphorus is present in two fractions, from one of which a homogeneous phosphoprotein has been isolated. (springer.com)
  • Cohen-Solal, L., Lian, J. B., Kossiva, D., Glimcher, M. J.: Identification of organic phosphorus covalently bound to collagen and non-collagenous proteins of chicken bone matrix: the presence of O -phosphoserine and O -phosphothreonine in non-collagenous proteins, and their absence from phosphorylated collagen, Biochem. (springer.com)
  • Deposition of bone in physiology involves timed secretion, deposition and removal of a complex array of extracellular matrix proteins which appear in a defined temporal and spatial sequence. (scielo.br)
  • This leading idea fueled a large volume of studies, which originally capitalized on the identification of biochemical procedures for extraction of proteins buried in the mineral compartment of bone (1,2), and thus not amenable to extraction by usual denaturing agents. (scielo.br)
  • Identification of a number of bone-enriched noncollagenous proteins and cognate genes ensued, which was later followed by the development of a number of transgenic and knockout models developed with the aim of identifying the specific biological function of individual proteins. (scielo.br)
  • Today, the original idea of the mechanistic relationship between bone proteins and mineralization is in need of significant revision. (scielo.br)
  • Most of the proteins originally thought to be unique of the bone ECM have been proven to be expressed in other tissues as well, whereas, ironically enough, a role for osteocalcin (the only protein still reasonably assumed to be bone specific) in bone mineralization has been dispelled by the regular occurrence of bone mineralization in osteocalcin-deficient mice (3). (scielo.br)
  • A single well-defined function has not been identified conclusively for any of the bone-enriched noncollagenous proteins. (scielo.br)
  • Nonetheless, a number of unexpected biological events in which bone noncollagenous proteins are involved have emerged and are currently the focus of intensive investigation. (scielo.br)
  • Ninety percent of the organic matrix of bone is made up by collagen type I, and 10% by a variety of noncollagenous proteins. (scielo.br)
  • A comparison between enamel matrix proteins used alone or in combination with bovine porous bone mineral in the treatment of intrabony periodontal defects in humans. (biomedsearch.com)
  • BACKGROUND: It has been shown that clinical improvement of intrabony periodontal defects can be achieved with the use of enamel matrix proteins (EMPs) or by grafting with bovine porous bone mineral (BPBM). (biomedsearch.com)
  • Intrabony defects were treated either with enamel matrix proteins (EMP group) or with enamel matrix proteins combined with bovine porous bone mineral (EMP/BPBM group). (biomedsearch.com)
  • When the experimental group had attained a 20% loss of their original body weight, we extracted the ECM proteins from bone marrow with PBS buffer, and analyzed ECM samples by SDS-PAGE (7.5%) and ECL Western blotting. (scielo.br)
  • The hematopoietic microenvironment is composed of stromal cells (fibroblasts, macrophages, endothelial cells, adipocytes), accessory cells (T lymphocytes, monocytes), and their products (extracellular matrix (ECM) proteins and cytokines), which influence the self-renewal, proliferation and differentiation of hematopoietic stem and progenitor cells (4). (scielo.br)
  • Using the 2D-difference in gel electrophoresis technique and mass spectrometry, we analyzed the composition of murine mineral-associated proteins of calvaria and long bone. (uva.nl)
  • Although cystatin motifs containing proteins, such as secreted phosphoprotein 24 and fetuin are highly expressed in long bone, they did not inhibit the activity of the cysteine proteinases cathepsin B and K. The solubility of collagen differed which coincided with differences in collagen crosslinking, long bone containing 3× more (hydroxylysine)-pyridinoline. (uva.nl)
  • The result is a material composed by collagen (type I principally), proteins no-collagen type and growth factors such as bone morphogenetic proteins (BMPs) [ 8 , 9 ]. (alliedacademies.org)
  • ie tartrate-resistant acid phosphatase (TRAP) and cathepsin K. We also wanted to clarify the role of the extracellular matrix proteins bone sialoprotein, osteopontin and fibronectin. (avhandlingar.se)
  • 8] C. Knabe, G. Berger, R. Gildenhaar, J. Meyer, C.R. Howlett, B. Markovic, H. Zreiqat, Effect of rapidly resorbable calcium phosphates and a calcium phosphate bone cement on the expression of bone-related genes and proteins in vitro, J Biomed Mater Res A. 69 (2004). (scientific.net)
  • It also contains human bone morphogenetic proteins (BMPs), specifically, BMP-2, BMP-4 and BMP-7, as well as a transforming growth factor beta 1. (jcda.ca)
  • We report that MSC differ from fibroblasts in their binding to proteins of the extracellular matrix. (nmi.de)
  • We conclude that overall MSC seem less selective with respect to binding extracellular matrix components compared to fibroblasts, and fibroblasts attach to fewer proteins and peptides. (nmi.de)
  • Overall, the data demonstrate that modulation of MSC differentiation occurs at the transcriptional level and gene expression of bone-related proteins is differentially regulated by the ECM. (ru.nl)
  • The organic portion of the bone matrix is made up of, like I said, osteoid, which consists of a soft but highly ordered structure of proteins and then collagen, specifically Type I collagen. (corenatherapeutics.com)
  • The solid matrix is composed of proteins and sugars. (corenatherapeutics.com)
  • It is of interest that the 35% increase in cell numbers on the trabecular bone surface is similar to the proportion of the bone surface exhibiting expression of genes for bone matrix proteins. (corenatherapeutics.com)
  • It does this through its ability to activate two proteins, osteocalcin and matrix-GLA protein, thereby shunting calcium in the proper direction. (cytomatrix.ca)
  • Removing the bone mineral leads to the exposal of bone morphogenetic proteins which are biologically more active. (qyresearchgroups.com)
  • Mature bone is composed of proteins and minerals. (washington.edu)
  • About 90% of the matrix proteins are collagen, which is the most abundant protein in the body. (washington.edu)
  • The following table gives information about some of the other bone matrix proteins that seem most important. (washington.edu)
  • Bone matrix proteins: their function, regulation, and relationship to osteoporosis. (washington.edu)
  • Phosphorylated Extracellular Matrix Proteins of Bone and Dentin is the second volume of the e-book series Frontiers between Science and Clinic in Odontology. (benthambooks.com)
  • The phosphorylated proteins of the extracellular matrix of bone and teeth play a crucial structural role in the two tissues. (benthambooks.com)
  • Phosphorylated extracellular matrix proteins have been implicated in nucleation and mineralization of skeletal tissues. (benthambooks.com)
  • This e-book covers research on these specific proteins, including details about the cells producing these molecules, their impact on bone and teeth pathology (osteogenesis and dentinogenesis imperfecta) and the potential of these molecules in promoting of inhibiting mineralization. (benthambooks.com)
  • Derived from healthy acellular porcine bone, TissueSpec® bone matrix is a network rich in collagen types I and III and other carboxylated proteins that contribute to bone mechanics, mineral nucleation, and osteocytogenesis. (xylyxbio.com)
  • Fibronectin is one of the earliest proteins to be assembled into the ECM and facilitates assembly of other matrix proteins. (grantome.com)
  • The first is that fibronectin is a multifunctional regulator of osteoblast differentiation and function through its effects as a central orchestrator for assembly of bone ECM proteins and through its role in ECM regulation of growth factor activity. (grantome.com)
  • The second is that dynamic cell movement is essential for the assembly and reorganization of bone ECM proteins. (grantome.com)
  • Aim 1 will define the cascade of assembly of bone ECM proteins and its integration with cell and matrix dynamics. (grantome.com)
  • This will be done using fibronectin null osteoblast models in conjunction with live cell molecular imaging of bone ECM proteins and quantification of cell and fibril dynamics by computational analysis. (grantome.com)
  • The data generated will significantly advance our understanding of the molecular and dynamic mechanisms underlying bone formation and have key implications for skeletal diseases such as osteoporosis, arthritis, osteogenesis imperfecta and bone diseases related to ECM proteins. (grantome.com)
  • We will for the first time dynamically image the assembly process by which key bone matrix proteins are deposited in living bone cells and determine how the motile properties of the cells contribute to the building of the protein scaffold for mineral deposition. (grantome.com)
  • In bone, for example, collagen accounts for up to 90% of the proteins in the extracellular matrix. (devourdeals.com)
  • These growth factors modulate the differentiation of progenitor cells into osteoprogenitor cells, which are responsible for bone and cartilage formation. (wikipedia.org)
  • Endochondral bone formation in gelatin methacrylamide hydrogel with embedded cartilage-derived matrix particles. (sigmaaldrich.com)
  • Therefore, we set out to engineer endochondral bone in gelatin methacrylamide (GelMA) hydrogels with embedded multipotent stromal cells (MSCs) and cartilage-derived matrix (CDM) particles. (sigmaaldrich.com)
  • Cartilage provides the bone-promoting matrix and bone-forming progenitor cells required for the formation of long bones. (sciencemag.org)
  • found that HDAC3 promotes pre- and postnatal bone growth by restricting the secretion of inflammatory factors from cartilage cells called chondrocytes. (sciencemag.org)
  • INSERM U 349, Cell and Molecular Biology of Bone and Cartilage, Lariboisière Hospital, 75475 Paris Cedex 10, France. (jci.org)
  • A substantial amount of the calcified cartilage in the distal parts of the epiphyseal plate is resorbed during endochondral growth of long bones. (avhandlingar.se)
  • Fibronectin is associated with collagen type I in bone and may be involved in collagen fibril formation or mineralization, but is apparently not involved in cell-matrix interaction in highly differentiated cartilage or bone. (avhandlingar.se)
  • Taken together, knockout mice and transgenic mice generated provide us a new insight for the functional analysis of the cells embedded in bone and cartilage matrix. (nii.ac.jp)
  • However, the determination of cartilage and bone degradation remains time consuming and problematic. (brillonline.com)
  • A rapid rat model of Mycobacterium tuberculosis monoarticular arthritis with induces of inflammation, as well as patellar cartilage proteoglycan and bone degradation has been reported. (brillonline.com)
  • Levamisole inhibited cartilage and bone degradation without affecting joint inflammation. (brillonline.com)
  • Naproxen, piroxicam, diclofenac and tiaprofenic acid all inhibited joint inflammation and bone loss, but naproxen and piroxicam both significantly potentiated cartilage proteoglycan loss. (brillonline.com)
  • These results were attributed to the cellular interactions with growth factors and matrix molecules that are likely present in the in vitro generated ECM since the genes for insulin-like growth factor 1, insulin-like growth factor 2, vascular endothelial growth factor, dentin matrix protein, collagen type IV, cartilage oligomeric protein, and matrix metalloproteinase 13 were significantly upregulated during ECM construct generation. (ru.nl)
  • Cartilage smoothen bone surfaces at joints. (corenatherapeutics.com)
  • Bone of the first type begins in the embryonic skeleton with a cartilage model, which is gradually replaced by bone. (corenatherapeutics.com)
  • The bone matrix has a lower proteoglycan content than those in the cartilage. (corenatherapeutics.com)
  • The demineralized bone matrix will be used in promoting bone and cartilage repair and bone and cartilage growth and regeneration. (justia.com)
  • 5)immature cartilage cells which secrete the matrix? (corenatherapeutics.com)
  • Extracellular matrix, which is made up of an organic matrix (30%) containing proteoglycans (but less than cartilage), glycosaminoglycans, glycoproteins, osteonectin (anchors bone mineral to collagen) and osteocalcin (calcium binding protein). (aramram.tv)
  • Continual efforts to develop improved allografts such as demineralized bone matrix grafts with greater osteoconductive and osteoinductive capabilities are anticipated to have a positive impact on the growth of the segment during the forecast period. (thefreedictionary.com)
  • Intraoperative extracorporeal autogenous irradiated bone grafts in tumor surgery," Clinical Orthopaedics and Related Research , no. 368, pp. 196-206, 1999. (hindawi.com)
  • However, in order to create relevant-size bone grafts, a cell carrier is required that ensures a high diffusion rate and facilitates matrix formation, balanced by its degradation. (sigmaaldrich.com)
  • This work offers a new avenue for the engineering of relevant-size bone grafts, by the formation of endochondral bone within a degradable hydrogel. (sigmaaldrich.com)
  • Demineralized bone matrix grafts were used in 82% of trauma surgery and 89% of foot/hand cases. (springer.com)
  • These bone substitutes are classified, according to their origin, into allogenic grafts (from another individual of the same specie), xenogenic grafts (from other species) and alloplastic grafts (produced synthetically) [ 5 , 6 ]. (alliedacademies.org)
  • ReproBone® is an advanced range of UK manufactured synthetic and resorbable bone grafts that stimulate, integrate and regenerate natural bone. (opnews.com)
  • Allograft bone grafts are advantageous from the standpoint of being available in larger quantities compared to autologous bone grafts. (justia.com)
  • However, allograft bone grafts may present disadvantages relating to histocompatibility issues (e.g., rejection by recipient immune system), the potential harboring of infectious agents, and may also include bone with poor malleable or mechanical characteristics (e.g., elasticity, compressibility, resiliency, and the like) due to high calcium and mineral content. (justia.com)
  • Demineralized bone matrix becomes biologically active as compared to the bone grafts which are undemineralized as a result of the demineralization procedure. (qyresearchgroups.com)
  • More particularly, this invention relates to a superior collagenous bone matrix useful as a xenogenic implant for use as an osteogenic device, as a bone particle coating for implantable prostheses, as a delivery vehicle for the in vivo sustained release of protein, and as a scaffold for anchorage-dependent cells. (google.com)
  • NASDAQ: WMGI), a global orthopaedic medical device company, today announced a supply and distribution agreement with AlloSource for FUSIONFLEX[TM] Bone Matrix , a unique bone repair scaffold for use in primary fusion procedures of the foot and ankle, as well as other orthopaedic bone grafting applications. (thefreedictionary.com)
  • The objective of this study was to prepare a cell-free decellularized human IVD scaffold and to compare neotissue formation in response to recellularization with human IVD cells (hIVDCs) or human bone marrow-derived (hBM) mesenchymal stromal cells (MSCs). (figshare.com)
  • The mechanical and physical properties of the scaffolds (porosity, compressive strength, solubility) and their potential to facilitate homogenous colonization by osteogenic cells and extracellular bone matrix formation throughout the porous scaffold architecture prior to in vivo implantation were examined. (scientific.net)
  • Spine fusion was evaluated by manual palpation, and osteointegration and de novo bone formation within scaffold struts were evaluated by laboratory and synchrotron microcomputed tomography and histology. (envisiontec.com)
  • New bone was identified extending from the host transverse processes into the scaffold macropores, and osteointegration scores correlated with successful fusion. (envisiontec.com)
  • Strikingly, the combination of HA and DBM resulted in the growth of bone-like spicules within the DBM particles inside scaffold struts. (envisiontec.com)
  • Bone scaffold architecture modulates the development of mineralized bone matrix by human embryonic stem cells. (semanticscholar.org)
  • C-MSC can regulate the cellular function in vitro and induce successful bone regeneration using ECM as a cell scaffold. (biomedcentral.com)
  • The processing of the bone sweeps off the osteoinductive and osteogenic capabilities of the graft, thus leaving just an osteoconductive scaffold behind. (qyresearchgroups.com)
  • The extracellular matrix (ECM) is a scaffold where the cells exist. (aramram.tv)
  • 2 , - 4 One of the alternatives to overcome membrane collapse is the use of a graft material to support the membrane by filling the space beneath, which may also act as a scaffold of bone ingrowth. (allenpress.com)
  • The extracellular matrix (ECM) has been viewed as a static three dimensional scaffold that supports cells and tissues. (grantome.com)
  • This research is relevant to public health as it will provide highly novel insights into the dynamic processes by which the bone extracellular matrix (i.e. the protein scaffold outside the cells onto which mineral is deposited) is assembled. (grantome.com)
  • Abstract: This study evaluated periodontal repair and biomaterial reaction following implantation of a newly fabricated calcium phosphate chitosan block bone and chitosan membrane on the regeneration of 1- wall intrabony defects in the beagle dogs. (scientific.net)
  • Chitosan membrane group significantly enhanced bone regeneration compared to control, CaP-chitosan block bone and combination group. (scientific.net)
  • The combination of enamel matrix derivative (EMD) with an autogenous bone graft in periodontal regeneration has been proposed to improve clinical outcomes, especially in case of deep non-contained periodontal defects, with variable results. (mdpi.com)
  • The aim of the present systematic review and meta-analysis was to assess the efficacy of EMD in combination with autogenous bone graft compared with the use of EMD alone for the regeneration of periodontal intrabony defects. (mdpi.com)
  • Bone regeneration is a major challenge regarding defects that exceed a critical size. (fraunhofer.de)
  • PURPOSE: The aim of the present study was to test whether or not a synthetic matrix consisting of a polyethylene glycol (PEG) hydrogel containing recombinant human bone morphogenetic protein-2 (rhBMP-2) combined with grafting materials enhances bone regeneration compared with grafting alone or empty control sites. (uzh.ch)
  • CONCLUSIONS: It is concluded that rhBMP-2 significantly enhances bone regeneration in rabbits when delivered by a synthetic matrix containing HA/TCP. (uzh.ch)
  • To compare bone regeneration in the critical-sized bone defects grafted with demineralized bone matrix, platelet-rich fibrin, and hyaluronic acid in rats. (ovid.com)
  • The sole usage of HA does not effectively increase bone regeneration when compared with DBM and PRF. (ovid.com)
  • The DBM and PRF do not have superiority to each other in the bone regeneration while they are superior to HA. (ovid.com)
  • Positive osteostimulative effect - the high surface area of nano-hydroxyapatite attracts and binds biomolecules essential for bone repair and regeneration. (opnews.com)
  • Xenotransplantation of C-MSCγ into immunocompetent mice calvarial defect induced bone regeneration, whereas C-MSC xenograft failed and induced T cell infiltration in the grafted area. (biomedcentral.com)
  • On the other hand, both C-MSC and C-MSCγ xenotransplantation into immunodeficient mice caused bone regeneration. (biomedcentral.com)
  • Xenotransplantation of C-MSCγ, which exerts immunomodulatory properties via the upregulation of IDO activity in vitro, may attenuate xenoreactive host immune response, and thereby induce bone regeneration in mice. (biomedcentral.com)
  • Accordingly, C-MSCγ may constitute a promising novel allograft cell therapy for bone regeneration. (biomedcentral.com)
  • GBR is a technique used for the regeneration of lost alveolar bone by the help of a grafting material and a barrier membrane. (botiss-indications.com)
  • Large particles enables a better revascularization and bone formation between the particle, therfore, should be preferred for the regeneration of larger defects. (botiss-indications.com)
  • Mixing of a bone substitue material with autologous bone is always beneficial, as it confers a biological activity (osteo-inductive and osteo-genetic properties of autologous bone) that supports faster regeneration and improved formation of new bone. (botiss-indications.com)
  • Maximizing the porosity of the material allows for increased void space available for bone regeneration and ingrowth. (collagenmatrix.com)
  • The statistical analysis revealed that the mean percentage of new bone regeneration in group A was higher than in group B (49.38% and 40.31%, respectively). (allenpress.com)
  • The recipe for growing healthy bones includes not only a precise biological mix -- bone cells called "osteoblasts" and several growth factors that osteoblasts use to build the mineralized matrix of bones -- but also mechanical stimulation. (innovations-report.com)
  • The success of a bone graft is determined by its ability to recruit host cells to the site of the graft and modulate their conversion into bone forming cells such as osteoblasts, to repair the defect. (wikipedia.org)
  • The ratio of collagen to noncollagen protein in bone is highly variable throughout the different physiological scenarios of bone formation (from embryonic development to adult remodeling to aging, Ref. 5) and reflects specific changes in the secretory function of the bone-producing cells, the osteoblasts. (scielo.br)
  • Further, MSCs from Igf1rflox/flox mice with Igf1r deleted by a Cre adenovirus in vitro, although recruited to the bone surface after implantation, were unable to differentiate into osteoblasts. (nih.gov)
  • Bone-lining cells appear to play a role in the activation of osteoblasts and osteoclasts, responding to hormones and changing conditions in the body to trigger the most appropriate activity. (corenatherapeutics.com)
  • The other category is the osteoblast family, which consists of osteoblasts that form bone, osteocytes that help maintain bone, and lining cells that cover the surface of the bone. (corenatherapeutics.com)
  • Remodeling commences with signals that initiate o â ¦ These same cells can also differentiate to become matrix-synthesizing osteoblasts. (corenatherapeutics.com)
  • For example, certain collagen peptides have been demonstrated to stimulate fibroblast activity and influence collagen production in the skin, while other collagen peptides act on osteoblasts to promote bone health. (cytomatrix.ca)
  • The ability of a grafted bone to set up the host cells on the grafted area and carry outthe modulation of their conversion to the cells which are responsible for the formation of bone which include osteoblasts in order to restore the defect is used to determine whether a bone graft is successful or not. (qyresearchgroups.com)
  • In the previous funding cycle, using fibronectin null cell culture models and targeted gene deletion in osteoblasts, it was shown that fibronectin is essential for assembly of multiple bone ECM components, including type I collagen, fibrillin-1, Latent TGF2 binding protein-1, decorin and biglycan and is also required for normal mineralization. (grantome.com)
  • Modified (flattened) osteoblasts become the lining cells that form a protective layer on the bone surface. (wikipedia.org)
  • Bone is actively constructed and remodeled throughout life by special bone cells known as osteoblasts and osteoclasts. (wikipedia.org)
  • In January, 1998, Osteotech filed its initial patent infringement suit against GenSci accusing it of violating claims of a patent issued to Osteotech involving the company's Grafton Demineralized Bone Matrix products. (thefreedictionary.com)
  • The demineralized bone matrix (DBM) Strip implant primarily is used for posterior lumbar fusion, a surgical procedure intended to promote bone fusion along the posterior elements of the spine. (thefreedictionary.com)
  • In January 1998, Osteotech filed its initial suit against GenSci accusing it of violating claims of a patent issued to Osteotech involving the company's Grafton Demineralized Bone Matrix process, by making, using, and/or selling the invention claimed in Osteotech's patent without permission or license from Osteotech. (thefreedictionary.com)
  • These observations demonstrate the dissociative extraction and successful biological reconstitution of bone inductive macromolecules in demineralized bone matrix. (pnas.org)
  • Demineralized bone matrix (DBM) is allograft bone that has had the inorganic mineral removed, leaving behind the organic "collagen" matrix. (wikipedia.org)
  • In this study, we developed an injectable carrier for demineralized bone matrix (DBM) which consists of chitosan and glycerol phosphate (GP). (scientific.net)
  • In situ gel forming implant in vivo was successfully fabricated by simple subcutaneous injection of chitosan and GP solutions with demineralized bone matrix (DBM). (scientific.net)
  • MTF says it will continue to distribute its Grafton Demineralized Bone Matrix , which is processed by Osteotech, Inc. (thefreedictionary.com)
  • The market currently has five segments: allograft, demineralized bone matrix (DBM), bone graft substitutes, machined bone and recombinant human bone morphogenetic protein (rhBMP). (thefreedictionary.com)
  • This study evaluated the effectiveness of demineralized bone matrix as a graft material after intramedullary decompression for the treatment of unicameral bone cysts. (pubmedcentralcanada.ca)
  • Between October 2008 and June 2010, twenty-five patients with a unicameral bone cyst were treated with intramedullary decompression followed by grafting of demineralized bone matrix. (pubmedcentralcanada.ca)
  • The demineralized bone matrix (DBM) is originated from human material, obtained when the cortical or corticalcancellous bone is processed in an acid solution following liofylization process to remove the bone mineral components [ 8 ]. (alliedacademies.org)
  • Forty Wistar Albino rats allocated into 4 experimental groups: platelet-rich fibrin (PRF) group, noncross-linked hyaluronic acid gel (HA) group, demineralized bone matrix in putty form (DBM) group, and control group. (ovid.com)
  • We compared the healing rates and failures of two methods of cure based on multiple injections of corticosteroid or a single injection of demineralized bone matrix (DBM) in association with bone marrow concentrate (BMC). (springermedizin.de)
  • In this study, "3D-Paints" containing varying volumetric ratios of hydroxyapatite (HA) and human demineralized bone matrix (DBM) in a poly(lactide-co-glycolide) elastomer were three-dimensional (3D) printed into scaffolds to promote osteointegration in rats, with an end goal of spine fusion without the need for recombinant growth factor. (envisiontec.com)
  • Osteocel®Plus is an allograft cellular bone matrix containing mesenchymal stem cells (MSCs) and osteoprogenitor cells combined with Demineralized bone matrix (DBM) and cancellous bone. (lifemapsc.com)
  • Accell Connexus demineralized bone matrix putty (Citagenix Inc., Laval, QC) is composed of 70% (by weight) allogeneic demineralized, freeze-dried bone matrix (DFDBM). (jcda.ca)
  • Objectives: To compare fusion rates of different production lots of demineralized bone matrix (DBM) to a dose response curve of rhBMP-2 in inactive DBM for posterolateral lumbar spinal fusion in an athymic rat model. (yale.edu)
  • Summary of Background Data: Demineralized bone matrix (DBM) preparations are available as bone graft supplements. (yale.edu)
  • A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. (justia.com)
  • The present invention relates to a process for manufacturing demineralized bone matrix. (justia.com)
  • More specifically, the present invention relates to a method for manufacturing demineralized bone matrix, which focuses on the preservation of native/intrinsic growth factors residing within the matrix while providing unique handling characteristics. (justia.com)
  • A large area of nondigested demineralized bone matrix is covered by bone lining cells (arrows). (corenatherapeutics.com)
  • Demineralized bone matrix a bone which has undergone allotransplantation. (qyresearchgroups.com)
  • This procedure significantly leads to the reduction of the mechanical properties of the demineralized bone matrix. (qyresearchgroups.com)
  • The global market for demineralized bone matrix is estimated to increase at significant compound annual growth rate (CAGR) during the forecast period of 2014-2022. (qyresearchgroups.com)
  • Growth in the geriatric population and positive aspects of the technique such as faster recovery, reduced postoperative time has led to the expansion of the market industry for demineralized bone matrix. (qyresearchgroups.com)
  • The concept of demineralized bone matrix has become popular in the recent times. (qyresearchgroups.com)
  • Demineralized bone matrix has emerged as an useful technique in the medical field. (qyresearchgroups.com)
  • Allografts, demineralized bone matrices, synthetic bone graft substitutes, and osteoinductive growth factors are all viable options, yet there is a lack of data reporting clinical usage of these products. (springer.com)
  • Approximately half (48.6%) of all bone graft substitutes were implanted during spinal surgery. (springer.com)
  • Of all bone graft substitutes used in arthroplasty, 14.4% were demineralized bone matrices, whereas 56.8% were allografts. (springer.com)
  • In order to prevent or to recover the bone loss are used autologous bone and bone substitutes. (alliedacademies.org)
  • This study describes the in vitro construction of cell-seeded bone substitutes with pre-vascularization via bioreactor technology. (fraunhofer.de)
  • Collectively, our work suggests that this recombinant growth factor-free composite shows promise to overcome the limitations of currently used bone graft substitutes for spine fusion. (envisiontec.com)
  • We are the developer and manufacturer of xenograft and the provider of synthetic bone graft substitutes. (collagenmatrix.com)
  • 12 , - 14 As an alternative, bone graft substitutes such as xenografts, allografts, or alloplastic materials have been proposed. (allenpress.com)
  • The matrix may be combined with osteogenic protein to induce reliably and reproducibly endochondral bone formation. (google.com)
  • Osteogenic phenotype expression of allogeneic rat marrow cells in porous hydroxyapatite ceramics," Journal of Bone and Mineral Research , vol. 14, no. 4, pp. 561-568, 1999. (hindawi.com)
  • When combined with bone marrow aspirate, CONFORM SHEET becomes osteogenic. (medgadget.com)
  • Currently, autograft bone harvested from the iliac crest is considered the 'gold standard' due to its superior osteogenic properties. (wikipedia.org)
  • The results show that Apert FGFR-2 mutations lead to an increase in the number of precursor cells that enter the osteogenic pathway, leading ultimately to increased subperiosteal bone matrix formation and premature calvaria ossification during fetal development, which establishes a connection between the altered genotype and cellular phenotype in Apert syndromic craniosynostosis. (jci.org)
  • The combination of BioVaSc and ß-TCP granules results in a construct that presents characteristics that favor fast bone formation by introducing cells with osteogenic potential on a material with osteoconductive properties as well as a matrix that provides nutritional support for the resident cells via its vascular structures that can be connected to a host's circulatory system. (fraunhofer.de)
  • For example, autologous bone is typically viscoelastic, osteoconductive, osteoinductive, and osteogenic (i.e., contains cells in its matrix that promote bone formation). (justia.com)
  • The aim of the study was the histomorphometric comparison of the osteogenic potential of β-tricalcium phosphate (β-TCP) alone or in a calcium sulfate matrix. (allenpress.com)
  • 10 , 11 Furthermore, one of the main advantages of using autogenous bone, that is, its osteogenic and osteoinductive potential, has been questioned lately, since studies have shown that it undergoes necrosis. (allenpress.com)
  • The resulting ptychography-enhanced calcium distribution allowed then to observe a locally lower degree of mineralization of the perilacunar matrix. (nature.com)
  • Mineralization itself plays a role in dictating and spatially orienting the deposition of matrix. (scielo.br)
  • RPS seeded with a 3x10 6 cells per ml displayed greatest cell and extracellular matrix formation, mineralization and osteocalcin expression. (scientific.net)
  • The only way calcium can become part of your bones is by attaching itself to collagen (known as mineralization). (legacyharbourhotel.com)
  • The goal of this work was to evaluate the ability of Raman spectroscopy to identify molecular organization and chemical composition of extracellular matrix such as the collagen fibers arrangement, the level of mineralization, and the carbonate accumulation in mineral phase in spongy bone of the human head of the femur. (devourdeals.com)
  • It is the bone mineralization that give bones rigidity. (wikipedia.org)
  • Disclosed is a matrix material for implantation in a mammalian host comprising biocompatible mineral-free type I bone collagen, xenogenic to the host, and biodegradable therewithin. (google.com)
  • DBM has superior biological properties to undemineralised allograft bone, as the removal of the mineral increases the osteoinductivity of the graft. (wikipedia.org)
  • Bone is a two-phase porous composite material comprised primarily of collagen and mineral, which together provide its mechanical properties. (nih.gov)
  • Although collagen may have less effect on bone's strength and stiffness than does mineral, it may have a profound effect on bone fragility. (nih.gov)
  • Many of these events have revealed complexities of bone physiology which were not accounted for by the original, simplistic idea of a bone-specific mineral nucleator and also exceed the limits of biomineralization to extend into cell migration, angiogenesis, assembly of the matrix, maintenance of its mechanical properties, cell-matrix-interaction, and more. (scielo.br)
  • Mice with knockout of the IGF-1 receptor (Igf1r) in their pre-osteoblastic cells showed lower bone mass and mineral deposition rates than wild-type mice. (nih.gov)
  • Volumetric bone mineral density (BMD) ( b ), trabecular bone volume fraction (TBV/TV) ( c ), trabecular number (Tb. (nih.gov)
  • Bone and Mineral. (nii.ac.jp)
  • Its natural mineral structure closely resembles the crystal lattice of bones and teeth. (nutriplusdirect.com)
  • A powdered blend of targeted bioactive collagen peptides to support osteoblast activity and bone mineral density, with added calcium, magnesium, vitamin K2 and vitamin D3. (cytomatrix.ca)
  • A double-blind, randomized human clinical trial found that 12 months of supplementation with Fortibone® collagen bioactive peptides significantly increased bone mineral density of the spine and femoral necks of postmenopasaul women with osteopenia or osteoporosis. (cytomatrix.ca)
  • The material structure of carbonate apatite, being similar to the mineral structure of natural bone, supports and facilitates remodeling of the new bone. (collagenmatrix.com)
  • An additional full product line of anorganic bovine bone mineral cancellous and cortical granules and composites is sold under private brands. (collagenmatrix.com)
  • Theinorganic mineral is removed from the bone leaving the organic collagen matrix. (qyresearchgroups.com)
  • Approximately 60% the weight of the bone is mineral, mainly calcium and phosphate. (washington.edu)
  • The rest is water and matrix, which is formed before the mineral is deposited, and can be considered the scaffolding for the bone. (washington.edu)
  • Almost 70% of bone is made up of bone mineral called hydroxyapatite. (aramram.tv)
  • ABM contains both the organic matrix and the mineral components of bone whereas DBM only retains the organic matrix. (aramram.tv)
  • SynOss Putty Synthetic Mineral‐Collagen Composite is a bone graft matrix with an additional characteristic that enables it to become moldable putty upon hydration. (ddsgadget.com)
  • The mineral particles are dispersed within collagen fibers forming a 3 dimensional matrix. (ddsgadget.com)
  • SynOss Putty Synthetic Mineral‐Collagen Composite is a bone graft matrix with an additional characteristic that enables it to become moldable putty upon hydration.Clinical studies of similar bone graft materials have shown improved results when used in conjunction with a barrier membrane 1 such as MatrixDerm, MatrixDerm Cap, MatrixDerm EXT, or MatrixMem Regenerative Collagen Dental Membranes. (ddsgadget.com)
  • Featuring a 1:1 ratio of calcium to magnesium, Bone Matrix gives your body the proper mineral balance it needs to maximize bone formation. (aceva.com)
  • This advanced mineral complex also has the unique addition of Vitamin K2, which prevents additional bone loss and enhances bone building even more. (aceva.com)
  • In fact, we're so confident that Bone Matrix will help you maintain your current bone mineral density, we've placed the Aceva Bone Matrix Guarantee on this product (see full description for details). (aceva.com)
  • The Bone Matrix Guarantee states that bone mineral density will increase or remain the same over a one year period. (aceva.com)
  • If bone mineral density decreases during this time, a full refund for the amount of all bottles of Bone Matrix purchased over the one year time period will be refunded. (aceva.com)
  • Mosekilde L. Effects of treatment with fluoride on bone mineral density and fracture risk--a meta-analysis. (legacyharbourhotel.com)
  • The extracellular matrix consists of about 15% water, 30% collagen fibers, and 55% crystallized mineral salts like calcium phosphate these then combines with another mineral salt, calcium hydroxide, to form crystals. (devourdeals.com)
  • The matrix is hardened by the binding of inorganic mineral salt, calcium phosphate, in a chemical arrangement known as calcium hydroxylapatite. (wikipedia.org)
  • The matrix is manufactured from protein-extracted bone powder treated with certain swelling agents to increase its surface. (google.com)
  • 9. The matrix of claim 8 wherein said swelling agent is an organic protein denaturant. (google.com)
  • Osteocalcin is an abundant Ca2+-binding protein indigenous to the organic matrix of bone, dentin, and possibly other mineralized tissues. (nih.gov)
  • These changes may be mediated by insulin-like growth factors (IGF-I and IGF-II), but the matrix bound binding protein, IGFBP-5 has not been investigated. (diva-portal.org)
  • Notably, injection of IGF-1 plus IGF binding protein 3 (IGFBP3), but not injection of IGF-1 alone, increased the concentration of IGF-1 in the bone matrix and stimulated new bone formation in aged rats. (nih.gov)
  • The objective of the present study was to determine the effect of protein malnutrition on the glycoprotein content of bone marrow extracellular matrix (ECM). (scielo.br)
  • Objective: Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. (harvard.edu)
  • The purpose of this study is to evaluate the effect of IGF-I for DNA synthetic activity and the mRNA expression of bone matrix protein, type I collagen and osteopontin in prolifetation and differentiation of MC3T3-E1 cells. (koreamed.org)
  • Colocalization of Noggin and bone morplugenetic protein during fracture liealing'J. (nii.ac.jp)
  • Colocalization of Noggin and bone morphogenetic protein-4 during fracture healing'J. (nii.ac.jp)
  • Recent evidence has suggested that the integrity of bone tissues can be maintained or improved by supplementing with the glycinerich protein blend. (cytomatrix.ca)
  • Some 10% of the protein in bone is made up of the 32,000-MW ECM protein osteonectin (or SPARC: secreted protein, acidic, cysteine-rich). (legacyharbourhotel.com)
  • Collagen is a flexible protein matrix upon which minerals are deposited to form bone. (legacyharbourhotel.com)
  • For instance in the bone matrix collagens account for up to 90% of the protein present. (devourdeals.com)
  • The classification of an extracellular matrix protein as a collagen is based on the presence of a domain with a distinctive triple-helical conformation. (devourdeals.com)
  • Background: In osteoarthritis cancellous bone adapts to meet altered mechanical loading. (diva-portal.org)
  • Methods: ρA, Ec, and IGF system components were measured in cancellous bone from superior and inferior regions of femoral heads from 31 patients with OA and 11 age selected controls. (diva-portal.org)
  • Selective immunodepletion processing was developed to purify the cellular cancellous bone matrix. (lifemapsc.com)
  • Cell-rich cancellous bone is processed to selectively deplete immunogenic components from the hematopoietic stem cell lineage (e.g. blood cells, lymphocytes,and osteoclasts), while retaining viable MSCs and osteoprogenitor cells. (lifemapsc.com)
  • 12. The sheet-form DBM device of claim 1, wherein the DBM particles are obtained from cortical, cancellous or cortico-cancellous types of bone, said types of bone being of autogenous, allogenic or xenogeneic origin. (patentsencyclopedia.com)
  • The hard outer layer of bones is composed of cortical bone, which is also called compact bone as it is much denser than cancellous bone. (wikipedia.org)
  • The endosteum is the boundary between the cortical bone and the cancellous bone. (wikipedia.org)
  • Cancellous bone has a higher surface-area-to-volume ratio than cortical bone and it is less dense. (wikipedia.org)
  • Cancellous bone is typically found at the ends of long bones, near joints and in the interior of vertebrae. (wikipedia.org)
  • Cancellous bone is highly vascular and often contains red bone marrow where hematopoiesis, the production of blood cells, occurs. (wikipedia.org)
  • However, the biological significance of mesenchymal stem cells (MSCs) and bone marrow derived extracellular matrix (BM-ECM) in this process is not fully understood. (strath.ac.uk)
  • Human bone marrow-derived MSCs were seeded at a density of 2.0 × 10 5 cells/well into 24-well plates and cultured with growth medium supplemented with 50 μg/mL L-ascorbic acid for 4 days. (biomedcentral.com)
  • It is well accepted the autologous implantation of bone marrow-derived MSCs induces bone formation at the sites of defects. (biomedcentral.com)
  • However, in order to apply bone marrow-derived MSCs to established bone regenerative medicine, there still remain problems to be overcome. (biomedcentral.com)
  • The in vitro production of mineralized matrix formed by immortalized mutant fetal calvaria cells cultured in aggregates was also increased markedly compared with control immortalized fetal calvaria cells. (jci.org)
  • In this study, the extent of bone marrow angiogenesis was investigated in patients with MGUS, nonactive and active MM. The in vivo and in vitro angiogenic potential and the MMP-2/MMP-9 expression of bone marrow plasma cells isolated from the same patients were also assessed. (bloodjournal.org)
  • Background and Objectives Mesenchymal stem cells (MSC) are adult stem cells that can be expanded many fold in vitro and have the therapeutic potential to restore the bone marrow microenvironment and support hematopoietic recovery after myeloablative conditioning for hematopoietic stem cell transplantation. (haematologica.org)
  • We studied in vitro the capacity of MSC to migrate through bone marrow endothelium. (haematologica.org)
  • 9] C. Knabe, A. Houshmand, G. Berger, P. Ducheyne , R. Gildenhaar , I, Kranz , M. Stiller, Effect of rapidly resorbable bone substitute materials on the temporal expression of the osteoblastic phenotype in vitro, J. Biomed Mater Res A. 84 (2008). (scientific.net)
  • Here we describe an engineered bone marrow model that mimics many features observed in patients and provides a platform for mechanistic in vitro studies. (strath.ac.uk)
  • The influence of an in vitro generated bone-like extracellular matrix on osteoblastic gene expression of marrow stromal cells. (ru.nl)
  • Previously, we have shown that an in vitro generated ECM secreted by cultured cells enhances the mineralized matrix deposition of marrow stromal cells (MSCs). (ru.nl)
  • Therefore, the aim of this study was to investigate the effect of IFN-γ on the immunomodulatory capacity of C-MSC in vitro and to test the bone regenerative activity of C-MSC or IFN-γ-pretreated C-MSC (C-MSCγ) xenografts in a mice calvarial defect model. (biomedcentral.com)
  • CRP increases bone matrix productions in pre- osteoblast cells and human fetal osteoblast cells in vitro. (technologypublisher.com)
  • In another embodiment, these materials include rhPDGF-BB, a deproteinized bone block or calcium phosphate, and a bioresorbable membrane. (freepatentsonline.com)
  • 15. The method of claim 1, wherein the biocompatible matrix comprises calcium phosphate or a bone block. (freepatentsonline.com)
  • The surgical control group received a flap operation only, while experimental group was treated with calcium phosphate chitosan block bone and/or chitosan membrane. (scientific.net)
  • Bone's rigid extracellular matrix contains mostly collagen fibers embedded in a mineralized ground substance containing hydroxyapatite, a form of calcium phosphate. (aramram.tv)
  • Calcium and Vitamin D. You already know that calcium is a critical component of bone, especially in the form of calcium phosphate and calcium carbonate. (legacyharbourhotel.com)
  • Bone charcoal contains a carbon structure while supporting a porous hydroxyapatite matrix (a calcium phosphate hydroxide in crystalline form which is rich in surface ions which can be readily replaced by fluoride ion). (legacyharbourhotel.com)
  • While the biological function of osteocalcin is unknown, it appears to be a highly specific osteoblastic marker produced during bone formation, and is rapidly becoming a clinically important diagnostic parameter of bone pathology. (nih.gov)
  • Two markers of bone synthesis, type I collagen carboxy-terminal propeptide and osteocalcin, were normal in all Pycno patients. (nih.gov)
  • The absence of γ -carboxyglutamic acid distinguishes it from osteocalcin, the noncollagenous γ -carboxyglutamic acid-containing peptide of bone matrix. (springer.com)
  • Upregulation of osteoblastic markers such as collagen type I, matrix extracellular phosphoglycoprotein with ASARM motif, parathyroid hormone receptor, and osteocalcin, indicated that the MSCs on plain titanium scaffolds differentiated down the osteoblastic lineage and deposited a mineralized matrix on day 12. (ru.nl)
  • Significant mineralized matrix deposition was observed as early as day 4 on ECM-containing scaffolds and was associated with the enhancement in expression of a subset of osteoblast-specific genes that included a 2-fold increase in osteopontin expression at day 1 and a 6.5-fold increase in osteocalcin expression at day 4 as well as downregulation of chondrogenic gene markers. (ru.nl)
  • Further, CRP mobilizes calcium and increases the expression of osteocalcin, a maker for bone matrix production. (technologypublisher.com)
  • Current methods of treating critical size bone defects include autografts and allografts, however, both present major limitations including donor-site morbidity, risk of disease transmission, and immune rejection. (semanticscholar.org)
  • Fresh bone allografts may be rejected by the host's immune system. (corenatherapeutics.com)
  • Vascularised or non-vascularised autologous fibular grafting for the reconstruction of a diaphyseal bone defect after resection of a musculoskeletal tumour," The Bone & Joint Journal , vol. 96, no. 9, pp. 1258-1263, 2014. (hindawi.com)
  • The current standard of autologous bone transplantation faces problems as donor site morbidity or limited availability of transplantable bone. (fraunhofer.de)
  • A single injection of DBM added with autologous bone marrow concentrate appears to provide a higher healing rate with a lower number of failures compared with a single injection of steroids. (springermedizin.de)
  • First, an autologous bone graft may be used. (justia.com)
  • An autologous bone graft is derived from the recipient and is commonly taken from the iliac bone. (justia.com)
  • Autologous bone graft, sometimes referred to as an autograft (i.e., the patient's own bone), may be harvested to supply the needed bone to repair the defect. (justia.com)
  • As appreciated by those skilled in the art, there are many advantages for using autologous bone in bone defect repair. (justia.com)
  • In addition, an autologous bone graft avoids histocompatibility and infectious disease issues. (justia.com)
  • Autologous bone, however, is limited in supply, is generally painful to the patient upon harvesting, and may lead to significant donor site morbidity (i.e., may require additional surgical incisions in the patient, may lead to surgical complications, blood loss and may cause additional patient discomfort, and may ultimately increase patient recovery time). (justia.com)
  • Biological therapy of bone defects: the immunology of bone allo-transplantation. (wikipedia.org)
  • These results suggest that Chitosan membrnae significantly enhanced bone and cementum formation in advanced periodontal defects. (scientific.net)
  • Histone deacetylase (HDAC) inhibitors may be therapeutic in various diseases, but their use causes birth defects and is detrimental to growing bones or the repair of injured bones. (sciencemag.org)
  • The findings explain why HDAC inhibitors cause skeletal defects and are ill-advised for children and pregnant women as well as for patients with bone fractures. (sciencemag.org)
  • All randomized controlled trials (RCTs) comparing a combination of EMD and autogenous bone graft with EMD alone for the treatment of periodontal intrabony defects were included. (mdpi.com)
  • rhBMP-2/CPM increased bone formation within core defects and surrounding trabeculae compared with CPM alone or no treatment at all anatomic locations at eight weeks, and bone formation was ongoing in the rhBMP-2/CPM-treated proximal tibial sites at twenty-four weeks. (biomedsearch.com)
  • Bone formation began in the trabeculae surrounding the core defects at one week and was observed adjacent to the resorbing CPM within the core defects and in the surrounding trabecular bone at two and four weeks in the rhBMP-2/CPM-treated distal radial sites. (biomedsearch.com)
  • Bone formation was confined to the region immediately surrounding the core defects in the untreated distal radial sites at all time points. (biomedsearch.com)
  • CLINICAL RELEVANCE: rhBMP-2/CPM may be useful to accelerate healing of metaphyseal bone defects in humans. (biomedsearch.com)
  • Small horizontal defects, in particular defects inside the ridge contour, can predictably be treated with many kind of bone substitute materials. (botiss-indications.com)
  • Group B (β-TCP) defects were partially filled with new bone, the graft particles still dominated the area, while the outer cortex was not restored. (allenpress.com)
  • Cell sheet transplantation of cultured mesenchymal stem cells enhances bone formation in a rat nonunion model," Bone , vol. 46, no. 2, pp. 418-424, 2010. (hindawi.com)
  • We found that even the lowest flow rate produced a significant increase in the formation of mineralized bone. (innovations-report.com)
  • The higher the quantity of DBM to CP base in the product, the more rapid the bone formation. (lww.com)
  • Low doses of rhBMP‐2 added to DBM product enhanced remodeling and rapid bone formation at all ratios of DBM to base. (lww.com)
  • As is clinically practice, autogeneous bone added to the DBM‐based product also enhanced rapid bone formation. (lww.com)
  • Interestingly, in an osteochondral setting, the presence of chondrocytes in one half of the constructs fully impeded bone formation in the other half by MSCs. (sigmaaldrich.com)
  • For example, deposition of bone sialoprotein, a member of the small integrin-binding ligand, N-linked glycoprotein family, represents the first step of bone formation in ectopic transplantation systems in vivo . (scielo.br)
  • Scale bar: 1 mm. ( g ) Calcein double labeling of the metaphyseal trabecular bone at distal femora (Scale bar: 1 mm). ( h ) Bone formation rate per bone surface (BFR/BS). (nih.gov)
  • To better understand how HDAC inhibitors affect endochondral bone formation, we conditionally deleted one of their targets, Hdac3 , pre- and postnatally in type II collagen α1 (Col2α1)-expressing chondrocytes. (sciencemag.org)
  • Increased calvaria cell differentiation and bone matrix formation induced by fibroblast growth factor receptor 2 mutations in Apert syndrome. (jci.org)
  • Histological analysis revealed premature ossification, increased extent of subperiosteal bone formation, and alkaline phosphatase- positive preosteoblastic cells in Apert fetal calvaria compared with age-matched controls. (jci.org)
  • RAYNHAM, Mass. , Feb. 13, 2017 /PRNewswire/ -- Today, DePuy Synthes*, in collaboration with LifeNet Health , launches ViviGen Formable Cellular Bone Matrix**, a second generation cellular allograft used to assist in the formation of bone during spinal fusion surgery. (medindia.net)
  • Both ViviGen and ViviGen Formable represent a paradigm shift in the field of bone repair by focusing on protecting viable, lineage committed bone cells from recovery to implantation while retaining all three properties required for bone formation, osteoinductivity, osteoconductivity and osteogenecity. (medindia.net)
  • These different formation modes may result in differences in the composition of the two bone types. (uva.nl)
  • Angiogenesis occurs primarily by endothelial migration and sprouting from preexisting blood vessels, while vasculogenesis involves the formation of blood vessels in situ by recruitment of precursor cells such as bone marrow (BM)-derived endothelial progenitor cells (EPCs) from the circulation. (pubmedcentralcanada.ca)
  • 4] P. Ducheyne, Q. Qiu, Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function, Biomaterials. (scientific.net)
  • These biomimetic materials act as ideal scaffolds to support bone formation and integration. (opnews.com)
  • In vivo bone formation by progeny of human embryonic stem cells. (semanticscholar.org)
  • less packed particles leave space for blood vessel ingrowth and formation of new bone matrix. (botiss-indications.com)
  • The ability of this technique to stimulate the bone formation has been the market driving factor for this. (qyresearchgroups.com)
  • Over 50 years ago, Urist made the key discovery that demineralized bone fragments implanted either subcutaneously or intramuscularly in animals induced bone formation. (aramram.tv)
  • It is fully resorbed during the natural process of bone formation and remodeling. (ddsgadget.com)
  • During the part of the life cycle prior to egg formation, a marked increase in osteoblastic activity occurs along the inside surfaces of the long bones, and the medullary cavities become filled with spongy bone. (legacyharbourhotel.com)
  • In group A sites (β-TCP/CS), complete bone formation was observed in all specimens, graft granules dominated the area, and a thin bridge of cortical bone was covering the defect. (allenpress.com)
  • In the ungrafted sites (group C), incomplete new bone formation was observed. (allenpress.com)
  • As these studies will significantly advance our mechanistic understanding the process of bone formation, the research has implications for treatment of osteoporosis, osteogenesis imperfecta and metabolic bone diseases. (grantome.com)
  • 7. The matrix of claim 3 wherein said matrix is shaped to span a non-union fracture in said mammalian host. (google.com)
  • However, there is evidence that changes in collagen content, or changes to inter- and intrafibrillar collagen cross-linking, can reduce the energy required to cause bone failure (toughness), and increase fracture risk. (nih.gov)
  • Collagen changes that occur with age and reduce bone's toughness may be an important factor in the risk of fracture in older women with low bone mass. (nih.gov)
  • Currently, the peptides are being evaluated in an OVX rat model to assess their effect on bone loss and bone fracture repair in vivo. (technologypublisher.com)
  • It is believed that this peptide or its analogues can be used to treat bone related diseases, like osteoporosis, and bolster fracture healing. (technologypublisher.com)
  • Proof of skeletal fluorosis, presenting without increased bone density, calls for a review of fracture incidence in areas with fluoridated groundwater, including an analysis of patients with low bone mass. (legacyharbourhotel.com)
  • Although numerous spinal biologics are commercially available, a cost-effective and safe bone graft substitute material for spine fusion has yet to be proven. (envisiontec.com)
  • Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells. (nih.gov)
  • We now report that IGF-1 released from the bone matrix during bone remodeling stimulates osteoblastic differentiation of recruited mesenchymal stem cells (MSCs) by activation of mammalian target of rapamycin (mTOR), thus maintaining proper bone microarchitecture and mass. (nih.gov)
  • Mesenchymal stem cells (MSC) are multipotent, adult stem cells predominantly residing in the stromal compartment of hematopoietic bone marrow. (haematologica.org)
  • Mesenchymal stem cell concentration and bone repair: potential pitfalls from bench to bedside. (semanticscholar.org)
  • Three-dimensional cultured clumps of a mesenchymal stem cell (MSC)/extracellular matrix (ECM) complex (C-MSC) consists of cells and self-produced ECM. (biomedcentral.com)
  • This high-quality, resorbable biomaterial is a non-setting, injectable matrix which combines the early stimulative activity of nanostructured hydroxyapatite with the longer term support of highly porous micro-scaffolds. (opnews.com)
  • Facilitates vascularisation and bone growth throughout its highly interconnected porous structure. (opnews.com)
  • Bone contains a porous matrix that is rich in surface ions. (legacyharbourhotel.com)
  • Within their limits, the obtained results indicate that the combination of enamel matrix derivative and autogenous bone graft may result in non-significant additional clinical improvements in terms of CALgain, PDred, and RECinc compared with those obtained with EMD alone. (mdpi.com)
  • 5 , - 9 Nowadays, a large number of filling materials are available, among which autogenous bone is still considered to be the gold standard. (allenpress.com)
  • However, harvesting autogenous bone has its disadvantages: secondary donor site surgery, extended operating time, risk of complications, as well as limited amount of graft material. (allenpress.com)
  • Cortical bone from animals injected with [ 14 C]glucosamine contains radioactivity derived from glucosamine and plasma glycoproteins and all glycoprotein fractions are labelled. (portlandpress.com)
  • Compact bone (or cortical bone) forms the hard external layer of all bones and surrounds the medullary cavity, or bone marrow. (corenatherapeutics.com)
  • The cortical bone gives bone its smooth, white, and solid appearance, and accounts for 80% of the total bone mass of an adult human skeleton. (wikipedia.org)
  • Cortical bone is covered by a periosteum on its outer surface, and an endosteum on its inner surface. (wikipedia.org)
  • The primary anatomical and functional unit of cortical bone is the osteon. (wikipedia.org)
  • Glimcher, M. J.: Composition, structure and organization of bone and other mineralized tissues and the mechanism of calcification. (springer.com)
  • Although a lot of information has been gathered on type V collagen, its function in bone or other tissues remains poorly understood. (elsevier.com)
  • The structure of connective tissues is an extracellular matrix. (corenatherapeutics.com)
  • Xylyx Bio also specializes in isolating extracellular matrix from additional tissues or specific regions within tissues of interest as well as other sources (e.g., human). (xylyxbio.com)
  • March 20, 2002 -- Calcium alone can't build strong bones and tissues. (legacyharbourhotel.com)
  • Bone is actually made predominantly of the ECM, and like Ken said, all tissues are made up the ECM and the cells that live inside it. (devourdeals.com)
  • Significant differences were found in the organic matrix composition of male and female bones of the two strains. (osti.gov)
  • An apparatus and technique for measuring volumetric, 3-D bone organic matrix density is described. (google.com)
  • Home Key Engineering Materials Advanced Biomaterials VII Injectable Chitosan Carrier for Demineralized Bone. (scientific.net)
  • ViviGen Formable augments the DePuy Synthes biomaterials portfolio and joins the first generation, ViviGen Cellular Bone Matrix, which launched in late 2014. (medindia.net)
  • Different biomaterials, classified according to their origin, are used to obtain these bone features. (alliedacademies.org)
  • Pycnodysostosis (Pycno) is an autosomal recessive osteosclerotic skeletal dysplasia that is caused by the markedly deficient activity of cathepsin K. This lysosomal cysteine protease has substantial collagenase activity, is present at high levels in osteoclasts, and is secreted into the subosteoclastic space where bone matrix is degraded. (nih.gov)
  • Chondrocytes from these mice had increased acetylation of a proinflammatory transcription factor as well as of histones in and near loci encoding secreted proinflammatory factors that promote matrix degradation and the proliferation and activity of bone-resorbing osteoclasts. (sciencemag.org)
  • These differences in collagen crosslinking may explain the differences in the proteolytic pathways osteoclasts use to degrade bone. (uva.nl)
  • and osteoclasts, which resorb bone. (corenatherapeutics.com)
  • Similarly, the ECM can influence the development of osteoclasts from undifferentiated macrophage precursor cells, and influence osteoclast function through direct osteoclast cell binding to matrix components. (aramram.tv)
  • Difference Between Compact and Spongy Bone Definition. (corenatherapeutics.com)
  • Spongy Bone Definition. (corenatherapeutics.com)
  • Spongy Bone (definition) ADVERTISEMENTS: There are three types of bone cells present in human body: 1. (corenatherapeutics.com)
  • Depending on the size & distribution of the spaces, the regions of a bone may be categorized as compact or spongy, about 80% of the skeleton is compact bone and 20% is spongy bone. (aramram.tv)
  • 6. The matrix of claim 3 wherein the particles define interstices dimensioned to permit influx, proliferation and differentiation of migratory cells from the body of said mammalian host. (google.com)
  • Bone-forming cells are clearly visible lining the walls. (innovations-report.com)
  • In more challenging applications, stem cells, matrix and/or growth factors must be provided within the 3D template. (medgadget.com)
  • Stem cells may be an alternative to an autograft because they have the potential to grow into a variety of cells and may help promote bone fusion. (spinerf.org)
  • The Spinal Research Foundation participated in a clinical trial that evaluated the effectiveness of Trinity Evolution bone matrix, an allograft that consists of bone chips with viable adult stems cells and bone precursor cells. (spinerf.org)
  • Trinity Evolution allograft can be preferable to autografts because of the higher number of bone-forming cells per volume and less associated surgical time and blood loss. (spinerf.org)
  • 01) was found between the extent of vascularization of the bone marrow of a given patient and the angiogenic activity exerted in the CAM assay by the plasma cells isolated from the same bone marrow. (bloodjournal.org)
  • This is paralleled by an increased angiogenic and invasive potential of bone marrow plasma cells, which is dependent, at least in part, by FGF-2 and MMP-2 production. (bloodjournal.org)
  • 1 Progression also involves secretion of the extracellular matrix-degrading enzymes such as metalloproteinase-2 (MMP-2 or 72-kD type IV collagenase) and MMP-9 (92-kD type IV collagenase) by tumor cells. (bloodjournal.org)
  • Blood cells arise in the bone marrow from stem cells able to undergo processes of proliferation and differentiation in the hematopoietic microenvironment. (scielo.br)
  • The bone marrow microenvironment is highly organized and regulates the location and physiology of the stem cells as well as the production and release of leukocytes and erythrocytes from bone marrow to peripheral blood. (scielo.br)
  • Fibronectin is a ubiquitous molecule, consisting of two similar subunits joined by disulfide bonds, and can be synthesized by bone marrow stromal cells. (scielo.br)
  • Bone sialoprotein located outside the clear zone of chondroclasts has a potential role in interaction between these cells and their adjacent matrix. (avhandlingar.se)
  • In rickets, clast-like cells are able to establish a cell-matrix interaction. (avhandlingar.se)
  • Results We demonstrated that MSC can invade reconstituted basement membrane and that bone marrow endothelial cells stimulate this process. (haematologica.org)
  • Tumor vasculature is derived from sprouting of local vessels (angiogenesis) and bone marrow (BM)-derived circulating cells (vasculogenesis). (pubmedcentralcanada.ca)
  • cells that produce new bone matrix are? (coursehero.com)
  • All components of each lot of Osteocel are from the same donor, and the cells are not removed from their native matrix. (lifemapsc.com)
  • The spread of prostate cancer cells to the bone marrow microenvironment and castration resistant growth are key steps in disease progression and significant sources of morbidity. (strath.ac.uk)
  • The function and development of cells rely heavily on the signaling interactions with the surrounding extracellular matrix (ECM). (ru.nl)
  • On the other hand, the animal studies revealed that the bone metastasis was abolished when TSP-2 was stably knocked down in PCa cells. (biomedcentral.com)
  • In PCa, MMP-2 and MMP-9 are considered useful prognostic markers and are correlated to PCa progression [ 6 ], indicating that the interaction between tumor cells and extracellular matrix is associated with tumorigenesis. (biomedcentral.com)
  • with one another and with cells outside of the bone matrix. (corenatherapeutics.com)
  • Blood has a fluid (liquid) matrix called plasma, in which red blood cells (RBCs), white blood cells (WBCs) and platelets are suspended. (corenatherapeutics.com)
  • Due to its natural bone structure cerabone® provides optimal support for bone forming cells and blood vessels. (botiss-indications.com)
  • Bone remodeling is carried out by temporary structures known as basic multicellular units (BMU), which maintain the same spatial and temporal relationships between their constituent cells for several months. (corenatherapeutics.com)
  • There are two categories of bone cells. (corenatherapeutics.com)
  • Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide a surface for inorganic salt crystals to adhere. (corenatherapeutics.com)
  • In this lecture we look at the cells that produce, maintain and break down bone. (corenatherapeutics.com)
  • On the outside of bones there is another layer of cells that grow, repair and remodel bone as well. (corenatherapeutics.com)
  • stress sensors= respond to mechanical stimuli=bone remodelling cells (blasts/clasts). (corenatherapeutics.com)
  • D ) Tom+ Prg4-traced cells ( arrows ) they secrete acids that dissolve bone matrix and release calcium and into. (corenatherapeutics.com)
  • Cellular and extracellular matrix is covered by bone lining cells ( described later ) cause the bone ) cell! (corenatherapeutics.com)
  • Look at the cells of the bone to grow, repair, and brain cells cells that maintain the and! (corenatherapeutics.com)
  • Extracellular Matrix: The extracellular matrix is the non-cellular material located between cells. (devourdeals.com)
  • This matrix is secreted by the cells. (devourdeals.com)
  • Here we see the microscopic structure of bones that contains an extracellular matrix that surrounds cells. (devourdeals.com)
  • Bones protect the various organs of the body, produce red and white blood cells, store minerals, provide structure and support for the body, and enable mobility. (wikipedia.org)
  • Bone is not uniformly solid, but consists of a flexible matrix (about 30%) and bound minerals (about 70%) which are intricately woven and endlessly remodeled by a group of specialized bone cells. (wikipedia.org)
  • The columns are metabolically active, and as bone is reabsorbed and created the nature and location of the cells within the osteon will change. (wikipedia.org)
  • Within these spaces are bone marrow and hematopoietic stem cells that give rise to platelets, red blood cells and white blood cells. (wikipedia.org)
  • The following four treatment modalities were randomly allocated: (1) empty control, (2) a combination of a PEG matrix and hydroxyapatite/tricalciumphosphate (HA/TCP) granules and a combination of a PEG matrix containing either 10 microg/ml (3) or 30 microg/ml (4) of BMP-2 and HA/TCP granules. (uzh.ch)
  • But Bone Matrix Calcium contains a special form of calcium known as Microcrystalline Hydroxyapatite Calcium (MCHC). (nutriplusdirect.com)
  • 3 The extracellular matrix of bone consists of a. collagen fibers b. calcium hydroxyapatite crystals. (devourdeals.com)
  • The long bones of normal and Op/Orl mutant rats were incubated with /sup 14/C-glucose and fractionated by EDTA and urea extraction. (osti.gov)
  • The analytical results of the various extracts suggested an increase in structural glycoprotein content and a decrease in collagen solubility in the long bones of mutants. (osti.gov)
  • misc{etde_6165893, title = {Biochemical studies of the macromolecular matrix of long bones in the Op/Orl mutant rat strain} author = {Moczar, E, Berenholc, S, Phan-Dinh-Tuy, B, and Robert, A M} abstractNote = {The long bones of normal and Op/Orl mutant rats were incubated with /sup 14/C-glucose and fractionated by EDTA and urea extraction. (osti.gov)
  • They are found in the metaphysis of long bones with the most common site being the proximal humerus followed by the proximal femur even though they may be found in the calcaneus and pelvis. (pubmedcentralcanada.ca)
  • The mammalian skeleton consists of bones that are formed in two different ways: long bones via endochondral ossification and flat bones via intramembranous ossification. (uva.nl)
  • The trabeculae are aligned towards the mechanical load distribution that a bone experiences within long bones such as the femur. (wikipedia.org)
  • Although the effects of osteolytic metastasis on bone quantity have been well studied, whether osteoclast activation induced by cancer bone metastasis affects the bone microstructure, a notable aspect of the bone quality, remains uncertain. (go.jp)
  • Likewise, in age-related osteoporosis in humans, we found that bone marrow IGF-1 concentrations were 40% lower in individuals with osteoporosis than in individuals without osteoporosis. (nih.gov)
  • Together, these results provide mechanistic insight into how IGF-1 maintains adult bone mass, while also providing a further rationale for its therapeutic targeting to treat age-related osteoporosis. (nih.gov)
  • Bone: modulation of IGF-1 might prevent osteoporosis. (nih.gov)
  • Osteoporosis Treatments Affect Bone Matrix Maturation in a Rat Model of Induced Cortical Remodeling. (fluoridealert.org)
  • Most cases of osteoporosis aren't detected until you've already 'had a fall' and ended up in hospital, only to be told that osteoporosis has already stolen around 30% of your bone. (nutriplusdirect.com)
  • Novel small peptide that has the ability to augment bone matrix production, potentiating its use for the treatment of osteoporosis and other bone related diseases. (technologypublisher.com)
  • Treatment of osteoporosis and other degenerative bone diseases. (technologypublisher.com)
  • Enhance the healing of osteoporosis related bone fractures. (technologypublisher.com)
  • One in two women over the age of 50 will break a bone due to osteoporosis. (aceva.com)
  • For this particular reason, various clinical studies had been successfully conducted in the use of this rich calcium source in bone substitution [12,13], treatment of osteoporosis , and more recently in … Skeletal fluorosis in humans: a review of recent progress in the understanding of the disease. (legacyharbourhotel.com)
  • The Top 4 Most Common Bone Calcium Killers (#1 Is In Water Pipes But It's Not Fluoride) Getting plenty of bioavailable calcium is crucial for reversing and preventing osteoporosis and osteopenia. (legacyharbourhotel.com)
  • Chronic environmental fluoride exposure under calcium stress causes fragility fractures due to osteoporosis and bone quality deterioration, at least in sheep. (legacyharbourhotel.com)
  • Determination of bone markers in pycnodysostosis: effects of cathepsin K deficiency on bone matrix degradation. (nih.gov)
  • The degradation of long bone collagen by MMP2 (but not by cathepsin K) was impaired. (uva.nl)
  • Alveolar ridge preservation (ARP) has been shown to prevent postextraction bone loss. (hindawi.com)
  • The present invention provides effective new methods and materials for maxillofacial bone augmentation, particularly alveolar ridge augmentation, that are free of problems associated with prior art methods. (freepatentsonline.com)
  • The mandible and maxilla are preferred bones for augmentation, and enhancement of the alveolar ridge is a preferred embodiment of the present invention. (freepatentsonline.com)
  • 4. The method of claim 1, wherein the maxillofacial site is a an alveolar ridge, a bone defect, a wall of the maxillary sinus, or an extraction socket. (freepatentsonline.com)
  • Alveolar bone reconstruction with a DFDBM allograft mixed with calcium sulphate graft binder was performed immediately. (jcda.ca)
  • Upon exposure and implant placement, the grafted alveolar ridge in all patients presented appropriately sized, dense and well-vascularized bone, wide enough to receive the planned wide-platform implant. (jcda.ca)
  • Posterior mandibular extraction sites with compromised buccal alveolar bone may be effectively managed by immediate alveolar augmentation using a mixture of DFDBM allograft and calcium sulphate graft binder. (jcda.ca)
  • A question of interest to general practitioners and specialists working in endosseous implantology is how to approach reconstruction of a postextraction alveolar bone defect. (jcda.ca)
  • This case series describes 3 patients in whom a mixture of Accell Connexus bone matrix putty and CalMatrix bone graft binder, which together have osteoconductive and osteoinductive capability, was used for immediate postextraction reconstruction of the alveolar ridge, before eventual placement of a posterior dental implant. (jcda.ca)
  • Pre-Operative Background Pre-operative clinical radiographic exam revealed adequate alveolar bone height in the #12 and #13 sites, however, the bone height was inadequate in the #14 and #15 sites due to the pneumatized sinus (Fig 1). (ddsgadget.com)
  • Objectives: To measure IGF-I, IGF-II, and IGFBP-5 in femoral head bone from non-OA controls and patients with OA, and to relate these to apparent density (PA) and elastic modulus (Ec). (diva-portal.org)
  • I am extremely happy with the bone volume and density. (ddsgadget.com)
  • I was very happy with the quality and density of the bone upon re-entry at 5 months after grafting with the SynOss Putty from Collagen Matrix Dental. (ddsgadget.com)
  • Sodium concentrations are too low to bother, sulfates have no documented bone effect, but fluoride can in rare cases be so high that it increases bone density. (legacyharbourhotel.com)
  • Radiographic and clinical assessment indicated adequate volume of bone for implant placement, with all planned implants placed in acceptable positions. (hindawi.com)
  • The implant may be used with DePuy Synthes Spine MATRIX™ MIS Pedicle Screw System and EXPEDIUM® Spine System, as well as other systems for spinal fusion. (medgadget.com)
  • Dental implant has proven to be a reliable long-term rehabilitation treatment showing considerable success rate and it is known that its stability depends on the bone quantity and quality present at the treated site. (alliedacademies.org)
  • The bone samples analyzed were obtained in the preparation phase for implant placement. (alliedacademies.org)
  • Additionally, it gives an insight into the regenerative potential of the bone substitute and illustrates the feasibility of the anastomosis of such an implant. (fraunhofer.de)
  • This case series reports short- and long-term healing, before and after placement of an implant, in posterior mandibular extraction sites grafted with demineralized, freeze-dried bone matrix (DFDBM) allograft mixed with calcium sulphate graft binder. (jcda.ca)
  • In particular, should the graft be placed at the time of extraction, to avoid the possibility of poor bone healing (which would necessitate grafting when the implant is placed)? (jcda.ca)
  • Washington, Nov 20 (ANI): In a breakthrough study, scientists have found that a synthetic bone matrix could offer hope for babies born with craniosynostosis- a condition that causes the plates in the skull to fuse too soon. (thefreedictionary.com)
  • GEM 21S was the first totally synthetic product combining a purified recombinant growth factor with a synthetic bone matrix to be approved by the FDA for human application. (thefreedictionary.com)
  • An increase in synthetic bone graft alternatives was noticed near the end of our investigation period. (springer.com)
  • The present studies' bone implants consist of synthetic ß-TCP granules with osteoconductive properties and a naturally derived collagen matrix (BioVaSc) that provides vascular structures. (fraunhofer.de)
  • This synthetic PEG matrix containing HA/TCP granules apparently fulfills a number of criteria required for an ideal carrier system for rhBMP-2. (uzh.ch)
  • If so, should an autogenic, allogeneic, xenogeneic or synthetic bone graft material, or a combination of these products, be used for the reconstruction? (jcda.ca)
  • CalMatrix bone graft binder (Citagenix Inc.) is a synthetic putty-like calcium sulphate bone graft binder containing calcium sulphate α-hemihydrate, sodium carboxymethyl cellulose and a hydrating solution. (jcda.ca)
  • A new study by Rice University researchers indicates that bioengineers growing bone in the laboratory may be able to create the mechanical stimulation needed to grow bone outside the body. (innovations-report.com)
  • Astronauts whose bones become brittle after months in orbit are a testament to the importance that mechanical stress plays in bone growth. (innovations-report.com)
  • Bone cultures were subjected to a range of three different flow rates to provide mechanical stimulation, and another set of cultures were grown in a motionless bath. (innovations-report.com)
  • Furthermore, we tested the bone remodeling activity of osteopontin-deficient mice with the loading of mechanical stress. (nii.ac.jp)
  • We detected GFP signal in osteocytes when mechanical stress loaded to bone. (nii.ac.jp)
  • Its mechanical nature provides support for locomotion and offers protection to vulnerable internal organs, it forms a reservoir for storage of calcium and phosphate in the body, and it provides an environment for bone marrow and for the development of … Tendon. (corenatherapeutics.com)
  • The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. (justia.com)
  • The extracellular matrix (ECM) is an intricate dynamic bio-environment with precisely regulated mechanical and biochemical properties. (aramram.tv)
  • Subcutaneous implantation of demineralized diaphyseal bone matrix in allogeneic rats results in the local induction of endochondral bone differentiation. (pnas.org)
  • A method of treatment for bone tumors comprising administering a matrix comprising collagen, a polysaccharide and a differentiation factor is provided. (expiredip.com)
  • Calcium "Binding Sites": collagen fibers serve as the "binding sites" for calcium and all bone minerals. (legacyharbourhotel.com)
  • Question: 3 The Extracellular Matrix Of Bone Consists Of A. Collagen Fibers. (devourdeals.com)
  • Bone matrix is 90 to 95% composed of elastic collagen fibers, also known as ossein, and the remainder is ground substance. (wikipedia.org)
  • MATERIAL AND METHODS: In each of 10 rabbits, four titanium cylinders were screwed in perforated slits made in the external cortical bones of the calvaria. (uzh.ch)
  • CONFORM SHEET is wickable in that it readily absorbs various hydrating fluids including bone marrow aspirate, blood or saline. (medgadget.com)
  • 3] W.W. Kalk, G.M. Raghoebar, J. Jansma, G. Boering, Morbidity from iliac crest bone harvesting, J. Oral Maxillofac Surg. (scientific.net)
  • Fusion sites were prepared and implanted with no graft, iliac crest autograft, or 0.2 cc per bone graft alternative. (yale.edu)
  • The autograft bone collected from iliac crest is taken to be the gold standard at present. (qyresearchgroups.com)
  • In the second application we mapped the calcium content in a human bone matrix in close proximity to osteocyte lacunae (perilacunar matrix). (nature.com)
  • The clinical relevance of these observations was determined by analyzing Erk phosphorylation in human bone metastatic prostate cancer versus non-metastatic prostate cancer, and increased phosphorylation was seen in the metastatic samples. (strath.ac.uk)
  • HCl), 8 M urea/1 M NaCl, and 1% NaDodSO4 at pH 7.4, containing protease inhibitors to solubilize putative inductive molecules in the bone matrix. (pnas.org)
  • Ca in bones) to constituents of essential biological molecules (e.g. (nature.com)
  • Integrin-mediated cell-matrix interactions play an important role in osteogenesis. (aramram.tv)
  • however, the high risk of pathologic fractures often justifies treatment that could reinforce a weakened bone cortex. (springermedizin.de)
  • Pathological fractures secondary to unicameral bone cysts. (springermedizin.de)
  • The various reconstituted matrices were bioassayed for bone inductive potential by quantitation of alkaline phosphatase activity and 45Ca incorporation on day 12 after implantation. (pnas.org)
  • Allograft bone is a logical alternative to autograft. (wikipedia.org)
  • Autograft has allograft bone as its logical alternative option but this carries negative aspects with itself. (qyresearchgroups.com)