Organosilicon Compounds: Organic compounds that contain silicon as an integral part of the molecule.Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].Photochemotherapy: Therapy using oral or topical photosensitizing agents with subsequent exposure to light.Photosensitizing Agents: Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.Indoles: Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Organometallic Compounds: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Optical Devices: Products or parts of products used to detect, manipulate, or analyze light, such as LENSES, refractors, mirrors, filters, prisms, and OPTICAL FIBERS.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.Ion Transport: The movement of ions across energy-transducing cell membranes. Transport can be active, passive or facilitated. Ions may travel by themselves (uniport), or as a group of two or more ions in the same (symport) or opposite (antiport) directions.Color: The visually perceived property of objects created by absorption or reflection of specific wavelengths of light.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Energy Metabolism: The chemical reactions involved in the production and utilization of various forms of energy in cells.Spectrometry, Fluorescence: Measurement of the intensity and quality of fluorescence.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Hybrid Cells: Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION.Immunoglobulin Fragments: Partial immunoglobulin molecules resulting from selective cleavage by proteolytic enzymes or generated through PROTEIN ENGINEERING techniques.Cell Line, Tumor: A cell line derived from cultured tumor cells.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Single-Chain Antibodies: A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Immunoglobulin Fab Fragments: Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.Genes, bcl-2: The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.bcl-2-Associated X Protein: A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Proto-Oncogene Proteins c-bcl-2: Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.Radioimmunotherapy: Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Eucommiaceae: A plant family of the order Eucommiales, subclass Hamamelidae, class Magnoliopsida (some botanists have classified this in the order Hamamelidales or Urticales). Eucomia is an elmlike tree of central and eastern China. Leaves are alternate; deciduous flowers are solitary and unisexual and lack petals and sepals. The male flowers have 6 to 10 stamens and female flowers have one ovary of two carpels, one of which aborts during development so the fruit (a dry, winged structure) contains only one seed. The latex is a source of RUBBER. Tochu tea is an aqueous extract of Eucommia ulmoides leaves and a popular beverage in Japan. (Mutat Res 1997 Jan 15;388(1):7-20).Yttrium Radioisotopes: Unstable isotopes of yttrium that decay or disintegrate emitting radiation. Y atoms with atomic weights 82-88 and 90-96 are radioactive yttrium isotopes.Academies and Institutes: Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Literature, ModernMedical Oncology: A subspecialty of internal medicine concerned with the study of neoplasms.Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.Lymphoma, B-Cell: A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.Aldehyde Dehydrogenase: An enzyme that oxidizes an aldehyde in the presence of NAD+ and water to an acid and NADH. This enzyme was formerly classified as EC 1.1.1.70.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Cyanamide: A cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Hematopoiesis: The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).Aldehyde Oxidoreductases: Oxidoreductases that are specific for ALDEHYDES.Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.Cell Lineage: The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.

Multicenter phase III trial to evaluate CD34(+) selected versus unselected autologous peripheral blood progenitor cell transplantation in multiple myeloma. (1/200)

High-dose chemotherapy followed by autologous transplantation has been shown to improve response rates and survival in multiple myeloma and other malignancies. However, autografts frequently contain detectable tumor cells. Enrichment for stem cells using anti-CD34 antibodies has been shown to reduce autograft tumor contamination in phase I/II studies. To more definitively assess the safety and efficacy of CD34 selection, a phase III study was completed in 131 multiple myeloma patients randomized to receive an autologous transplant with either CD34-selected or unselected peripheral blood progenitor cells after myeloablative therapy. Tumor contamination in the autografts was assessed by a quantitative polymerase chain reaction detection assay using patient-specific, complementarity-determining region (CDR) Ig gene primers before and after CD34 selection. A median 3.1 log reduction in contaminating tumor cells was achieved in the CD34 selected product using the CEPRATE SC System (CellPro, Inc, Bothell, WA). Successful neutrophil engraftment was achieved in all patients by day 15 and no significant between-arm difference for time to platelet engraftment occurred in patients who received an infused dose of at least 2.0 x 10(6) CD34(+) cells/kg. In conclusion, this phase III trial demonstrates that CD34-selection of peripheral blood progenitor cells significantly reduces tumor cell contamination yet provides safe and rapid hematologic recovery for patients receiving myeloablative therapy.  (+info)

Autologous transplantation of chemotherapy-purged PBSC collections from high-risk leukemia patients: a pilot study. (2/200)

We have recently demonstrated that the combination of the alkylating agent nitrogen mustard (NM) and etoposide (VP-16) is capable of eliminating, ex vivo, leukemic cells contaminating PBSC collections and this is associated with a significant recovery of primitive and committed hematopoietic progenitor cells. Based on these data a pilot study on autologous transplantation of NM/VP-16 purged PBSC for high-risk leukemic patients was recently initiated. Twelve patients (seven females and five males) with a median age of 46 years (range 18-57) have been treated. Two patients had acute myeloblastic leukemia (AML) resistant to conventional induction treatment, four patients had secondary AML in I complete remission (CR), one patient was in II CR after failing a previous autologous BM transplantation, while two additional AML individuals were in I CR achieved after three or more cycles of induction treatment. Two patients with high-risk acute lymphoblastic leukemia (ALL) in I CR and one patient with mantle cell lymphoma and leukemic dissemination were also included. Eight patients showed karyotypic abnormalities associated with a poor clinical outcome. The mobilizing regimens included cytosine arabinoside and mitoxantrone with (n = 6) or without fludarabine (n = 3) followed by subcutaneous administration of G-CSF (5 microg/kg/day until the completion of PBSC collection) and G-CSF alone (n = 3) (15 microg/kg/day). A median of two aphereses (range 1-3) allowed the collection of 7.2 x 10(8) TNC/kg (range 3.4-11.5), 5 x 10(6) CD34+ cells/kg (range 2.1-15.3) and 9.2 x 10(4) CFU-GM/kg (0.3-236). PBSC were treated with a constant dose of 20 microg of VP-16/ml and a median individual-adjusted dose (survival < or = 5% of steady-state BM CFU-GM) of NM of 0.7 microg/ml (range 0.25-1.25). Eleven patients were reinfused after busulfan (16 mg/kg) and Cy (120 mg/kg) conditioning with a median residual dose of 0.3 x 10(4) CFU-GM/kg (0-11.5). The median time to neutrophil engraftment (>0.5 x 10(9)/l) for evaluable patients was 25 days (range 12-59); the median time to platelet transfusion independence (>20 and >50 x 10(9)/l) was 40 days (18-95) and 69 days (29-235), respectively. Hospital discharge occurred at a median of 25 days (18-58) after stem cell reinfusion. Four individuals are alive in CR (n = 3) or with residual nodal disease (n = 1 lymphoma patient) with a follow-up of 32, 26, 3 and 14 months, respectively. Seven patients died due to disease progression or relapse (n = 5) or extrahematological transplant toxicity (n = 2). Our data suggest that pharmacological purging of leukapheresis collections of leukemic patients at high-risk of relapse is feasible and ex vivo treated cells reconstitute autologous hematopoiesis.  (+info)

Treatment of multiple myeloma. (3/200)

BACKGROUND AND OBJECTIVE: Multiple myeloma (MM) accounts for about 10% of all hematologic malignancies. The standard treatment with intermittent courses of melphalan and prednisone (MP) was introduced more than 30 years ago and, since then there has been little improvement in event-free and overall survival (EFS & OS). The aim of this article is to review: 1) the role of initial chemotherapy (ChT), maintenance treatment with alpha-interferon and salvage ChT, 2) the results of high-dose therapy (HDT) followed by allogeneic or autologous stem cell transplantation (allo-SCT and auto-SCT), and 3) the most important supportive measures. EVIDENCE AND INFORMATION SOURCES: The authors of this review have been actively working and contributing with original investigations on the treatment of MM during the last 15 years. In addition, the most relevant articles and recent abstracts published in journals covered by the Science Citation Index and Medline are also reviewed. STATE OF THE ART AND PERSPECTIVES: The importance of avoiding ChT in asymptomatic patients (smoldering MM) is emphasized. The criteria and patterns of response are reviewed. MP is still the standard initial ChT with a response rate of 50-60% and an OS of 2-3 years. Combination ChT usually increases the response rate but does not significantly influence survival when compared with MP. Exposure to melphalan should be avoided in patients in whom HDT followed by auto-SCT is planned, in order to not preclude the stem cell collection. The median response duration to initial ChT is 18 months. Interferon maintenance usually prolongs response duration but in most studies does not significantly influence survival (a large meta-analysis by the Myeloma Trialists' Collaborative Group in Oxford is being finished). In alkylating-resistant patients, the best rescue regimens are VBAD or VAD. In patients already resistant to VBAD or VAD and in those in whom these treatments are not feasible we recommend a conservative approach with alternate day prednisone and pulse cyclophosphamide. While HDT followed by autotransplantation is not recommended for patients with resistant relapse, patients with primary refractory disease seem to benefit from early myeloablative therapy. Although results from large randomized trials are still pending in order to establish whether early HDT intensification followed by auto-SCT is superior to continuing standard ChT in responding patients, the favorable experience with autotransplantation of the French Myeloma Intergroup supports this approach. However, although the complete response rate is higher with intensive therapy, the median duration of response is relatively short (median, 16 to 36 months), with no survival plateau. There are several ongoing trials comparing conventional ChT with HDT/autoSCT in order to identify the patients who are likely to benefit from one or another approach. With allo-SCT there is a transplant-related mortality ranging from 30 to 50% and also a high relapse rate in patients achieving CR. However, 10 to 20% of patients undergoing allo-SCT are long-term survivors (> 5 years) with no evidence of disease and, consequently, probably cured. The use of allogeneic peripheral blood stem cells (PBSC) in order to speed the engraftment and also the use of partially T-cell depleted PBSC which can decrease the incidence of graft-versus-host disease are promising approaches. In the setting of allo-SCT, donor lymphocyte infusion is an encouraging strategy in order to treat or prevent relapses. Finally, important supportive measures such as the treatment of anemia with erythropoietin, the management of renal failure and the use of bisphosphonates are reviewed.  (+info)

The cytotoxicity of mafosfamide on G-CSF mobilized hematopoietic progenitors is reduced by SH groups of albumin--implications for further purging strategies. (4/200)

The efficacy of mafosfamide purging depends on factors like incubation time, drug and erythrocyte concentration. To determine the influence of protein-bound SH groups in the incubation medium, the cytotoxicity of mafosfamide on G-CSF mobilized CD34+/- cells was evaluated by short-term culture assays and drug concentration measurements. 100 micromol/ml mafosfamide was incubated for 30 min in five buffers (PBS, PBS with 1%, 5% and 10% BSA and plasma). The mean calculated areas under the concentration-time curves (AUC) were 2489 +/- 198, 1561 +/- 286, 976 +/- 201, 585 +/- 62 and 605 +/- 196 micromol/l/min. The mean reductions of CFU-GM growth were 79.4%, 73.0%, 62.5%, 30.3%, 6.2% respectively. Similar results were obtained for BFU-E. Regression analysis showed a good correlation between cytotoxicity and AUCs (CFU-GM: r = 0.8195; BFU-E: r = 0.8207). This effect is well explained by the different concentrations of SH moieties in the incubation medium resulting in a higher drug binding capacity. The profound difference between AUCs and CFU-GMs in plasma and 10% BSA cannot be explained by the quantity of SH-groups. It is probably due to an additional enzymatic drug degeneration by the 3'-5'exonuclease subsite of plasma DNA polymerase. In conclusion, the concentration of albumin-associated SH groups strongly influences the cytotoxicity of mafosfamide. It has to be considered as a new and important aspect in ex vivo bone marrow purging.  (+info)

Hemopoietic progenitor cell mobilization and harvest following an intensive chemotherapy debulking in indolent lymphoma patients. (5/200)

An in vivo purging with intensive debulking chemotherapy prior to peripheral blood progenitor cell (PBPC) collection may reduce the risk of tumor contamination of the harvest products; however, it is usually associated with a marked reduction in PBPC mobilization. These issues have been considered while designing an adapted version of the high-dose sequential regimen for patients with lymphoid malignancies and bone marrow involvement. To reduce tumor contamination risks, PBPC collection was postponed to the end of the high-dose phase; however, in order to enhance progenitor cell mobilization, a chemotherapy-free lag period was introduced prior to the final mobilizing course. Thirty-nine patients (median age 47 years, range 26-62) with previously untreated indolent lymphoma entered this pilot study; all had advanced-stage disease, and 29 had overt marrow involvement. Sufficient numbers of PBPC to perform autograft with safety were harvested in 34 patients, with a median of 3 (range 2-5) leukaphereses. A median of 14.8 x 10(6) (range 2-51) CD34+/kg and 32.6 x 10(4) (range 1.77-250) colony forming units-granulocyte/macrophage/kg were collected per patient. In univariate analysis, the duration of the chemotherapy-free interval prior to the final mobilizing course, i.e. > or <65 days, was the most significant variable influencing progenitor mobilization. These data suggest that extensive in vivo tumor debulking is feasible provided that a sufficient chemotherapy-free period preceding the mobilizing course is allowed in order to allow a full recovery of marrow functions.  (+info)

Peripheral blood stem cell contamination in mantle cell non-Hodgkin lymphoma: the case for purging? (6/200)

Intensification using peripheral blood stem cells collected after chemotherapy followed by growth factors is being increasingly investigated as an alternative to conventional chemotherapy for mantle cell non-Hodgkin lymphoma. We investigated 14 grades III-IV, t(11;14)-positive cases for contamination of PBSC collected after a polychemotherapy regimen followed by G-CSF. Patients were first treated with a polychemotherapy regimen. There were four CR, seven PR, two refractory and one early death. Seven patients have been transplanted, in whom PBSC were mobilized, using either cyclophosphamide/VP16 or Dexa-BEAM followed by G-CSF. For all patients, whether actually autografted or not, PB cells were tested at the time of regeneration on G-CSF after the first polychemotherapy or after the mobilizing regimen. PCR evaluation of contamination was performed first by a semi-quantitative approach, using serial dilutions of initial DNA, then confirmed using a limiting-dilution analysis. Two patients were not informative (one early death and one without an available molecular marker). PB cells collected at regeneration contained at least one log more lymphoma cells than steady-state blood or marrow, apart from in two cases. Moreover, where a mobilizing treatment diminished tumor burden in the patient, at the same time it increased PB contamination in most cases. We conclude that advanced mantle cell NHL appears to be largely resistant to significant in vivo purging by conventional chemotherapy. Where treatment brings benefits by reducing tumor load, it may at the same time negate it by mobilizing malignant cells into the collections used to intensify. Although the clonogenic potential of this massive infiltration is unknown (only gene marking studies could provide a definitive answer regarding the source of relapses), strategies aimed at reducing the level of contamination in the graft should be considered when designing future protocols.  (+info)

Improved outcome with T-cell-depleted bone marrow transplantation for acute leukemia. (7/200)

PURPOSE: To eliminate the risk of rejection and lower the risk of relapse after T-cell-depleted bone marrow transplants in acute leukemia patients, we enhanced pretransplant immunosuppression and myeloablation. PATIENTS AND METHODS: Antithymocyte globulin and thiotepa were added to standard total-body irradiation/cyclophosphamide conditioning. Donor bone marrows were depleted ex vivo of T lymphocytes by soybean agglutination and E-rosetting. This approach was tested in 54 consecutive patients with acute leukemia who received transplants from HLA-identical sibling donors or, in two cases, from family donors mismatched at D-DR. No posttransplant immunosuppressive treatment was given as graft-versus-host disease (GVHD) prophylaxis. RESULTS: Neither graft rejection nor GVHD occurred. Transplant-related deaths occurred in six (16.6%) of 36 patients in remission and in seven (38.8%) of 18 patients in relapse at the time of transplantation. The probability of relapse was .12 (95% confidence interval [CI], 0 to .19) for patients with acute myeloid leukemia and .28 (95% CI, .05 to .51) for patients with acute lymphoblastic leukemia who received transplants at the first or second remission. At a median follow-up of 6.9 years (minimum follow-up, 4.9 years), event-free survival for patients who received transplants while in remission was .74 (95% CI, .54 to .93) for acute myeloid leukemia patients and .59 (95% CI, .35 to .82) for acute lymphoblastic leukemia patients. All surviving patients have 100% performance status. CONCLUSION: Adding antithymocyte globulin and thiotepa to the conditioning regimen prevents rejection of extensively T-cell-depleted bone marrow. Even in the complete absence of GVHD, the leukemia relapse rate is not higher than in unmanipulated transplants.  (+info)

Bone marrow harvesting using EMLA (eutectic mixture of local anaesthetics) cream, local anaesthesia and patient-controlled analgesia with alfentanil. (8/200)

Bone marrow harvesting (BMH) was performed on 40 consecutive allogeneic or autologous donors using EMLA (eutectic mixture of local anaesthetics), local anaesthesia (LA) and patient-controlled analgesia with alfentanil (PCA-A). The effect of alkalinizing the LA solution on reducing pain during LA infiltration in the presence of EMLA was also investigated. EMLA 10 g with occlusive dressing was applied to the harvest sites at least 60 min before BMH. The PCA device was programmed to deliver an intravenous loading dose of 15 microg/kg alfentanil, followed by a background alfentanil infusion of 0.05 microg/kg/min. Demand dose was 4 microg/kg and lockout time was 3 min. Donors were randomized to receive either alkalinized (n = 19) or non-alkalinized (n=21) LA solution (lignocaine 1% with 1:100000 adrenaline). While post-operative nausea and vomiting were the only side-effects, all donors in both groups reported satisfactory pain scores during LA infiltration and satisfactory overall intra-operative comfort scores. They completed BMH using either regimen successfully, found this technique acceptable and would recommend this form of anaesthesia to others. Alkalinizing the LA solution did not significantly improve the pain scores during LA infiltration in the presence of EMLA. In conclusion, BMH can be performed safely using EMLA, LA and PCA-A without major complications.  (+info)

*Perfosfamide

Pharmacologic Purging of Bone Marrow. Chapter 20 in Thomas' Hematopoietic Cell Transplantation, Volume 457. Eds. Thomas E.D. et ... Perfosfamide was used experimentally by oncologists in the 1980s for use in bone marrow transplant procedures for treatment of ... Scios Nova may purge Pergamid after FDA setback. Nature Biotechology. April 1993 11(4):439 doi 10.1038/nbt0493-439 The Pink ... "purge" a patient's own (autologous) collected hematopoietic stem cells of any malignant cells it may still contain at the time ...

*Edelfosine

Vogler, WR; Berdel WE (1993). "Autologous bone marrow transplantation with alkyl-lysophospholipid-purged marrow". Journal of ... doi:10.1016/0005-2760(78)90125-x. "A Phase I/II trial of edelfosine purging of autologous bone marrow transplantation (ABMT) in ... Edelfosine and other ALPs can be used for purging residual leukemic cells from bone marrow transplants. It is an analog of ... Most important, in contrast to many DNA-directed anti-cancer drugs, no bone marrow toxicity was in vivo observed. Those ...

*Allen C Eaves

Successful autografting in chronic myelogenous leukemia after maintenance of marrow in culture. Bone Marrow Transplant 4: 345- ... Eaves' personal research has focused on leukemia where he pioneered "culture purging" as a novel approach to doing autologous ... Successful autografting in chronic myeloid leukaemia after maintenance of marrow in culture. Bone Marrow Transplant 4: 345-351 ... Successful autografting in chronic myeloid leukaemia after maintenance of marrow in culture. Bone Marrow Transplant 4: 345-351 ...

*George W. Santos

... was a renowned expert in bone marrow transplantation. He became interested in bone marrow transplantation ... His other research were: The use of the drug 4-HC to purge patients' diseased marrow of cancer cells, allowing them to self- ... He founded the Johns Hopkins Oncology Center's bone marrow transplant program and served as its director from 1968 until his ... treatments to prevent and manage opportunistic infections in immuno-compromised bone marrow transplant patients; techniques in ...

*Hybridoma technology

It was concluded that immuno-histochemical staining of bone marrow aspirates are very useful to detect occult bone marrow ... In order to effectively stage breast cancer and assess the efficacy of purging regimens prior to autologous stem cell infusion ... Bone marrow aspirates of 22% of patients with localized prostate cancer (stage B, 0/5; Stage C, 2/4), and 36% patients with ... They concluded from the results that immuno-cytochemical staining of bone marrow and peripheral blood is a sensitive and simple ...

*Superantigen

"Induction of negative regulators of haematopoiesis in human bone marrow cells by HLA-DR cross-linking". Transpl. Immunol. 7 (3 ... Stiles BG, Krakauer (2005). "Staphylococcal Enterotoxins: a Purging Experience in Review, Part I". Clinical Microbiology ...

*List of civilian nuclear accidents

Six scientists received radiation doses of 2-4 sieverts (200-400 rem) (p. 96). An experimental bone marrow transplant treatment ... The operators purged the reactor's heavy water moderator, and the reaction stopped in under 30 seconds. A subsequent cover gas ... was performed on all of them in France and five survived, despite the ultimate rejection of the marrow in all cases. A single ...

*Cytotoxic T cell

Instead, the DNA in millions of white blood cells in the bone marrow is shuffled to create cells with unique receptors, each of ... by killing infected cells and by producing antiviral cytokines capable of purging HBV from viable hepatocytes, cytotoxic T ... Some TCRs have a gamma and a delta chain.) Hematopoietic stem cells in the bone marrow migrate into the thymus, where they ...

*Blood

In vertebrates, the various cells of blood are made in the bone marrow in a process called hematopoiesis, which includes ... Blood is purged from meat by rinsing and soaking in water (to loosen clots), salting and then rinsing with water again several ... During childhood, almost every human bone produces red blood cells; as adults, red blood cell production is limited to the ...

*Drowning

... and their presence in tissues such as bone marrow suggests drowning, however, they are present in soil and the atmosphere and ... Norton, Rictor (17 November 2011). "Newspaper Reports: The Dutch Purge of Homosexuals, 1730". Homosexuality in Eighteenth- ...

*No, Sir, No

Purslow, F; Marrow Bones: English Folk Songs from the Hammond and Gardiner Manuscripts; London, 1965 Stout, E J; Folklore from ... A song called "Consent At Last" printed in "Wit and Mirth: Or, Pills to Purge Melancholy" Volume 4, by Henry Playford, ... Playford, H; Wit and Mirth: Or, Pills to Purge Melancholy Volume IV; London; 1719 pp82-83 "The Spanish Merchant's Daughter / No ...
A lit purge occurs when your reading list gets too long and it needs to be culled of all the items that, frankly you are never going to read. Generally ...
Bone marrow transplantation, 1993; 11 (1) doi:. Authors: Hardingham J E, Kotasek D, Sage R E, Dobrovic A, Gooley T Hardingham J E, Kotasek D, Sage R E, Dobrovic A, Gooley T, Dale B M et al.(1) Affiliation: Queen Elizabeth Hospital, Woodville Australia Sample size: 10 Abstract: Twenty-seven patients with non-Hodgkins lymphoma (NHL) have undergone peripheral blood stem cell (PBSC) harvesting for autologous transplantation (Tx). A molecular marker was found at presentation in 23/27 patients. Immunoglobulin heavy chain (IgH) or T cell receptor beta (TCR beta) rearrangements were detected by Southern blotting or the polymerase chain reaction (PCR) in 13 patients; PCR detected the bcl-2/JH fusion in 10 patients. Fifteen autologous PBSC transplants have been performed in 11 patients. In 5/11 patients, the marker was present in at least one PBSC collection (in four patients, every PBSC collection was positive). Survival data are available for nine patients (two early deaths); three patients relapsed ...
RFC 6233 Registry Extension for Purges May 2011 3. Purges and Authentication Previous documents on authentication [RFC5304] [RFC5310] required that an IS only accept a purge if it only contained the Authentication TLV. This document updates and generalizes that behavior as follows: an implementation that implements authentication MUST NOT accept a purge that contains any TLV listed in the registry that is not acceptable in a purge. An implementation MUST NOT accept a purge that contains a TLV not listed in the registry unless the purge also contains the Purge Originator Identification (POI) TLV [RFC6232]. Purges that are accepted MUST be propagated without removal of TLVs. If multiple purges are received for the same LSP, then the implementation MAY propagate any one of the purges. If an implementation that implements authentication accepts a purge that does not include the POI TLV and it chooses to insert the POI TLV, it MUST also recompute authentication. ISs MUST NOT accept LSPs with a ...
A separate module is available that will allow you to purge aqueous samples onto an adsorbent tube at ambient termperatures. This module can also be used to generate a dynamic humidified stream of the carrier gas for spiking calibration standards. The purge and trap module includes purge and trap glassware, and a separate flow controller that allows the user to set a separate purge (wet) flow rate independently of the dry flow rate. The purge and trap module accepts standard 22 mL threaded vials to simplify your sample prep.
4075 Marko Mäkelä 2012-04-18 WL#5522: Remove trailing space from code and tests. modified: mysql-test/suite/sys_vars/r/innodb_purge_run_now_basic.result mysql-test/suite/sys_vars/r/innodb_purge_stop_now_basic.result mysql-test/suite/sys_vars/t/innodb_purge_run_now_basic.test mysql-test/suite/sys_vars/t/innodb_purge_stop_now_basic.test storage/innobase/btr/btr0btr.cc storage/innobase/fil/fil0fil.cc storage/innobase/mtr/mtr0mtr.cc storage/innobase/row/row0import.cc storage/innobase/row/row0mysql.cc 4074 Marko Mäkelä 2012-04-18 [merge] Merge mysql-trunk to mysql-trunk-wl5522. Several tests crash before and after this merge. To mention some: --suite innodb: innodb-wl5522-debug (glibc detected double free) --suite main: date_formats ctype_errors ctype_ucs ctype_utf8mb4_heap ctype_utf8mb4_myisam variables mysql ctype_utf8mb4 create-big added: mysql-test/suite/innodb/r/innodb-alter-discard.result mysql-test/suite/innodb/t/innodb-alter-discard.test modified: ...
Air Products Pipe Pigout app can calculate the nitrogen volume, flow rate and pressure suitable to push your pig and complete the purge or displacement of your pipeline.
View Notes - 04_LectureOutline from BIOLOGY 24011 at HCCS. Four Types of Tissues Tissues are collections of cells and cell products that perform specific, limited functions Types of tissue Epithelial
If you have created this page in the past few minutes and it has not yet appeared, it may not be visible due to a delay in updating the database. Try purge (http://academickids.com/encyclopedia/index.php?title=Sv:Gene_Wilder&action=purge), otherwise please wait and check again later before attempting to recreate the page ...
i am considering purchasing this product but i need to know if i will be able to save an excel file with ONLY the values, not the excel formulas that generated the values. to be clear, i want to create a template that …
Youd be amazed at the places Ive puked. Like a junkie knowing the hit that caused rock bottom, I remember my worst purge. Something shifted. Id been looking for help for years, but this experience shoved me.
Today in showbiz news: Changes are coming to The Walking Dead, ABC orders a funny-sounding new show, and The Purge is already a hit.
This randomized clinical trial addresses the effect of autologous BMC therapy on LVEF in patients with ischemic cardiomyopathy as a consequence of postinfarction myocardial scar. Patient characteristics in both groups were comparable. Complete revascularization was achieved in all patients, but a marginally higher number of bypass grafts were constructed in the BMC group (2.8±0.4) compared with the control group (2.5±0.5, P=0.07). Although these grafts were placed in remote, noninfarcted areas, they might have increased perfusion in the neighboring scar tissue and account for the better recovery of regional function in some of the BMC patients. However, the fact that the number of grafts in the "responder" and "nonresponder" group were similar makes this interpretation unlikely. There was no significant difference in global LVEF between both groups at 4-month follow-up. The increase in LVEF postoperatively was comparable in both groups (41.2±10.1% in controls versus 45.8±13.2% in the BMC ...
Usually when a branch name is specified, it means the latest check-in on that branch. But for some commands (ex: purge) a branch name on the argument means the earliest connected check-in on the branch. This seems confusing when being explained here, but it works out to be intuitive in practice. For example, the command "fossil purge XYZ" means to purge the check-in XYZ and all of its descendants. But when XYZ is in the form of a branch name, one generally wants to purge the entire branch, not just the last check-in on the branch. And so for this reason, commands like purge will interpret a branch name to be the first check-in of the branch rather than the last. If there are two or more branches with the same name, then these commands will select the first check-in of the branch that has the most recent check-in. What happens is that Fossil searches for the most recent check-in with the given tag, just as it always does. But if that tag is a branch name, it then walks back down the branch ...
The ability of the meat to hang on the water is dependent on several different things, including the species and age of the animal, the fatness and grade of the meat, the length of time since the animal was harvested, which muscle the cut of meat was from, and how the meat has been handled and processed. Meat scientists spend hours and hours trying to figure out purge and what causes it ...
4NEraserInstall.zip Download Free - Purge (Confidential Files Eraser) Free Download in Category Windows Software - Utilities - File Synchronizers
DefiniGEN provide a wide range of human cell products including liver, pancreas, and lung cells to the life science and drug discovery sectors using its proprietary OptiDIFF platform.
Homag Group is exhibiting the product CNC Manufacturing cells at LIGNA from 22 to 26 May. 2017 in Hannover, Germany. Plan your visit to the trade fair and search for further products.
Looking for online definition of autologous bone marrow transplantation in the Medical Dictionary? autologous bone marrow transplantation explanation free. What is autologous bone marrow transplantation? Meaning of autologous bone marrow transplantation medical term. What does autologous bone marrow transplantation mean?
TY - JOUR. T1 - Is there a place for autologous bone marrow transplantation in chronic myeloid leukemia?. AU - Frassoni, F.. AU - Carella, A. M.. PY - 1993. Y1 - 1993. UR - http://www.scopus.com/inward/record.url?scp=0027525235&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0027525235&partnerID=8YFLogxK. M3 - Article. C2 - 8298470. AN - SCOPUS:0027525235. VL - 11. SP - 1. EP - 3. JO - Stem Cells. JF - Stem Cells. SN - 1066-5099. IS - SUPPL. 3. ER - ...
Improved Recovery of Exfoliated Colonocytes from Feces Using Newly Developed Immunomagnetic Beads. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Were professional blower zero purge adsorption dryer manufacturers and suppliers in China, specialized in providing high quality customized products. We warmly welcome you to buy blower zero purge adsorption dryer from our factory ...
[117 Pages Report] Check for Discount on Global Nitrogen Purge Systems Market Professional Survey Report 2017 report by QYResearch Group. This report studies Nitrogen Purge Systems in Global market, especially...
No cell contamination observed with the magnetic wand in Pyrosequencing analysis. A. Representative pyrogram showing the G>A point mutation in the human EGFR gene in a sample with single SW48 cells (positive control). B. Representative pyrogram showing absence of the A allele in single HT-29 cells, transferred with the same unwashed magnetic wand as the SW48 cells. C. Frequency of the A allele in two pierced HT-29 cells (negative control), two pierced SW48 cells (positive control) and 24 pierced HT-29 cells. Single SW48 cells transferred using a clean magnetic wand (positive control) show a mean frequency of A allele (=point mutation) of 50.7%. Pierced single HT-29 cells transferred using an unwashed magnetic wand and analyzed for the presence of SW48 cell contamination showed a similar frequency of A allele when compared to the pierced single HT-29 cells transferred using the clean magnetic wand (negative control), indicating no contamination between the two cell lines, the arrays and the ...
Have an olfactory obsession? This spring, purge your home of chemically enhanced aerosol cans of air freshener and consider a few sweet-smelling, low-impact alt
Lately more and more packages that I use regularly are being deprecated and flagged for removal during upgrades. I use Sabayon for laptop for Enterprise Red Hat-based consulting. Some of my customers require app-admin/389-ds-console and net-misc/icaclient, which I often use daily without issue ...
RIPTX is a high-powered, thermogenic, stim-complex engineered for perfection. RIPTX contains nothing but proven and efficaciously-dosed ingredients, including 4 potent fat-burning ingredient combinations and 5 patented ingredients working in perfect synergy for ultimate body fat reduction.
Can anyone recommend how to purge using polyflex. Extruder is feeding filament, but not able to push existing material from head. Extruder is pushing ...
definition of ABMR, what does ABMR mean?, meaning of ABMR, Autologous Bone Marrow Reinfusion, ABMR stands for Autologous Bone Marrow Reinfusion
Turbo Torch 0386-1370 - NPK-TT Nitrogen Purge Kit (0-500 PSI) - The TurboTorch Nitrogen Purge Kit is designed with the professional in mind. This kit gives you the tools to pressure check HVAC and Refrigeration lines, flush drainage lines, blow clean components, and purge lines prior to brazing to protect the joints from oxidation.|br||br| |b|Includes:|/b||br| |ul||li|245-03P Nitrogen Regulator |li|Blow Gun |li|6 Hose |li|3 Hose |li|Turbo Tornado tip |li|3/4 Cone Plug |li|1/2 Cone Plug |li|Needle Tip |li|Tire Chuck |li|CO2 Adapter|/il||br|
Purge Unburned Butane From Your Cigars? - During the last CO Live show, our guest claimed that it was important to purge your cigar during lighting before you start puffing on it or the unburned butane from your torch would make its way in to the tobacco and spoil the cigar. Needless to say I was skeptical of the claim and it was bugging me. So lets try to prove or disprove that theory shall we?. ...
Gentaur molecular products has all kinds of products like :search , SBI \ Stem Cell Products mNAExpress hMyoD transcript 10 ug \ MR900A-2 for more molecular products just contact us
Find out some of the key trends in the stem cell products market, featuring insights from industry leading publisher, BioInformant Worldwide, L.L.C.
King Salman has appointed orpromoted 56 judges, Saudi Arabias state news agency SPAreported on Thursday, a step coinciding with an anti-corruptioncrackdown in the kingdom.
Yoga is inherently a cleansing practice. Committing to a regular meditation and asana practice purges our bodies of toxins: physical, spiritual and
TY - JOUR. T1 - A phase I clinical and pharmacological profile of dacarbazine with autologous bone marrow transplantation in patients with solid tumors. AU - Adkins, Douglas R.. AU - Irvin, Rebecca. AU - Kuhn, John. AU - Boldt, David H.. AU - Roodman, G. David. AU - Salzman, Donna. AU - Freytes, Cesar. AU - Von Hoff, D. D.. AU - LeMaistre, C. F.. PY - 1993/6. Y1 - 1993/6. N2 - Dacarbazine (DTIC) is a chemotherapy drug which has antitumor activity at standard doses, exhibits a steep dose-response effect in vitro, and is associated with relatively few non-hematologic toxicities. These characteristics suggest a potential role for this drug in bone marrow transplant preparative regimens. To pursue this hypothesis, 16 patients with refractory solid tumors were enrolled in a phase I study of single agent DTIC to determine the dose of DTIC requiring bone marrow reinfusion and to define the dose-limiting toxicity and maximum tolerated dose when given with autologous bone marrow rescue. Pharmacokinetics ...
The purpose of the current study is to establish a Liquid biopsy method (positive enrichment by a novel immunomagnetic beads capture assay) for detection of...
In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT. By the 1990s, it had burst upon the oncology scene and disseminated rapidly before having been carefully evaluated. By the time published studies showed that the procedure was ineffective, more than 30,000 women had received the treatment, shortening their lives and adding to their suffering.
This line was originally thought to be derived from normal amnion, but was subsequently found, based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting, to have been established via HeLa cell contamination.
The following glassware can be used in conjunction with the S.I.S. purge head adaptor to permit the use of the S.I.S. tube style liquid purge head for purging liquid and solid samples and trapping volatiles purged from the samples onto the S.I.S. Thermal Desorption Tubes ...
Our adventurers woke up after their rest still trapped in the depths of the Underdark. They had just defeated the frightening Basilisk that had apparently petrif
(Quote from Sherlock Holmes) Will you please elaborate on why you dont like Papp, and why there must be a purge of Papp believers?
(Quote from Sherlock Holmes) Will you please elaborate on why you dont like Papp, and why there must be a purge of Papp believers?
I used to call them bingeing and purging marathons. If I binged and purged in the morning, chances were, Id binge and purge throughout the day. The next time Id eat, I was likely to end up-whether I wanted to or not-bingeing and purging. Not all individuals with bulimia nervosa binge and purge every day (or purge everything they eat, for that matter), but many do, and some binge and purge multiple times a day. In recovery, many people start by trying not to binge and purge before a certain time of the day-because once they binge and purge, it triggers a continuous cycle of bingeing and purging until they become to exhausted or otherwise end up going to bed.. I always wondered why that was, why was it so hard to keep a single episode of bingeing and purging from initiating a repeated cycle of bingeing and purging?. On … Continue reading →. ...
Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Womens and Childrens Health. (Barnonkologisk forskning/Lönnerholm) ...
A manufacturing system for producing polyolefin includes a polymerization reactor, a flash chamber, and a purge column. In certain embodiments, the purge column may receive a solids stream directly from the flash chamber. Further, the purge column may function as a feed tank for an extruder within an extrusion/loadout system. According to certain embodiments, the manufacturing system may be configured to consume less than 445 kilowatt-hours of energy per metric ton of polyolefin produced based on consumption of electricity, steam, and fuel gas.
At NCA we provide our customers with a wide range of superior compressor packages, drilling systems and related equipment for mining, exploration and industrial applications
The results in 34 adult patients with acute myeloid leukemia (AML) who have undergone autologous bone marrow transplantation (ABMT) using busulfan and cyclophosphamide (Bu/Cy) in 12 United Kingdom (UK) centers have been analyzed. There were 19 females and 15 males; median age was 40 years (range, 21 to 62 years). Nine patients were in first relapse; 25 were in second remission. The median time of first remission for the whole group was 11.5 months (range, 1 to 56 months). All the patients in first relapse and six patients in second remission received first remission marrow. The leukemia-free survival (LFS) for the patients in first relapse was 33%, with a median follow-up of 20 months. The LFS for the patients in second remission was 48% with a median follow-up of 26 months. The length of second remission exceeds the length of first remission in 14 patients. Considerable toxicity with hemorrhagic cystitis (four patients; none fatal), venoocclusive disease (four patients; one fatal), pneumonitis ...
Ive tried with and without sudo, initially thinking that perhaps its unable to due to not having proper access, and they simply didnt program in a permissions check. Its the same error though.. I have a dual Xcode installation, which I believe may be the issue here. I have 3.2.6 installed to a custom directory (/Xcode 3) and I have Xcode 4.6.3 from the Mac App Store. Ive installed the most recent (2013.4) Command Line Tools from within Xcode 4. Im running OS X 10.7.4 Lion.. Before anyone tells me that I should let the OS manage inactive memory on its own because it does it fine, no, it doesnt. Not in the slightest. Normally it works well enough not to bother me. But whenever I use any type of VM, I encounter issues with the memory never releasing. For example, I can start an instance of an emulation VM. Itll use about 600 MB of memory. When I terminate the emulation entirely, the memory does not release. On top of that, if I go back and rerun the exact same emulation, the 600 MB sitting ...
JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles.
According to some reports Stalin was planning another purge. This time he wanted to get rid of his inner circle. On the 1st of March 1953 Stalins inner circle were invited to dine with him as usual. During the dinner Stalin got drunk and chased all the guests including Lavrenthi Beria, Nikita Khrushchev, Vyacheslav and Molotov. Expelling the visitors from the dinner table Stalin said "Its over for all of you". Then Beria knew that they were doomed. He realized that Stalin was planning another purge. After this incident less than 72 hours Stalin suffered a stroke and became unconscious. He was lying on the floor helplessly. Beria did not call the medics. At the last stage the Doctors wear called but it was too late. Stalin died. Stalins son General Vasily Dzhugashvili who was present at the Dictators death bed accused the top ranking officers (Beria?) for assassinating his father. Later Beria said to Nikita Khrushchev that I saved all of you from Stalins final blow. Considering all these ...
(not satire - its the UK today!) All MPs will be receiving this excellent spoof letter next week, highlighting the fact that the main people who are going to benefit from the governments decision to abolish Local Welfare Assistance, will be loan sharks: MPs will also be receiving pillow cases with the slogan How do you…
In this short article, Im going to examine the central aspects of expert leadership including how these components work together to effect positive and lasting change. As a professional leader, the formula I use to produce this change entails an easy but powerful four-step process that I highly recommend. And, in addition you might like to take up this great free business coaching offer which is available to eligible business owners and leaders.. No.1 Quality Questions for Quality Answers. Periodically, I wonder whether its more difficult to recognize where you are actually starting from or where youre specifically striving to get to!. As business people and entrepreneurs, we commonly fall into the trap of seeing our business with coloured glasses then fail to truthfully recognize where we are starting from - our point A.. Identifying your actual Point A is not easy: it is best accomplished by having the nerve to identify, ask, then truthfully address all of the confronting questions that ...
Time-saving characteristics of life videos. The characteristics of life include living things that are made of cells or cell products. Characteristics of life are one of the fundamental topics in Biology.
VOL.XXXII CuLUMBUS. OHIO, FRIDAY. AUGUST 12, 1570. NO. 90. i ? i THE OHIO STATE JOU ANAL nii.i.intitT. ,ihl lu Advance. MUUaarr ana ruw Uuouai (oltenieiil Felt TEUJ1 luwaarlnmr IB . HU aLaaad aod nd. a. Uwk A Hpitus; at. PAII.V liDITIOJII a do 6 moollia 2:. ! 5S ::::::::::: O.p,!xtr..oUub.0lT0. THI-WEM". I-DITIOW, 00 4 SO V VA 0 u V VII 4 Oil V 00 O DO 1. H. WII.KtB, llloarr. Uraa Tri ttooda, Aa., ltd BoatA Migb at., op. 01 Fuhtontblo MllltoarT, Uraaa Trimming., TsnflT WWUIOHOIMO a W. BIMMONB. WlfMeMla u4 B.- Ul UiUiorf 4odav ltl Bvath Hit. bu IJpat. Houm Block. Cincinnati, Aug 0,1870. TOTueoaio itathjourxau The tremendous ezcttcnient resulting from the news of tbe great victories of the PropsUDPtcontlnues unabated amooit THE VALLY OF TUB BAAB. Tbe Haar rises la the Voskts, tbe our TeutoulcFrienrts "over the Hhlne" r"K" mountains that lie west of KIKIK HAMT TA.ll.Ult.. aa tbe caual Is termed lu tbe Queen City. On Sunday evening while good men were Attending Divine (Service I rm.ki, IkmJa) ...
Objective:To report the outcomes of percutaneous autologous bone marrow injection for nonunion or delayed union of the distal tibial metaphysis in patients with prior plating.Design:Consecutive case series.Setting:Tertiary center.Patients:Eleven consecutive patients (aged 24-51 years) were referred
First things first: the best way to put an end to binges and purges is to establish a regular eating pattern, which consists of having 3 healthy meals and 2 to 3 wholesome snacks per day.. Are you already there? Then the healthy alternatives to binging and purging listed below will surely prove to be extremely beneficial for you. There are actually a couple of tools that can help you put an end to binging and purging once and for all, and they are practicing delays and doing alternatives.. Just like what the name says, practicing delays is all about delaying the urge to binge or purge. Basically, binging or purging follows a negative emotion such as anxiety, which is something that goes away on its own. Needless to say, practicing delays entails waiting for anxiety (or any other unfavorable emotion) to subside before binging or purging. By the time that the causative factor is gone, your urge to binge or purge is likely to be gone, too.. ...
The IPV D4 in fact gauges in slightly smaller than its predecessor, the IPV D3, with dimensions of 40mm x 24mm x 80mm, and also it considers in at a featherweight 126g. Running on the latest version of the YiHi SX310H chip, as with previous IPV mods the D4 has actually been developed to be as very easy to make use of as it gets. Plenty of power for a single 18650 battery gadget is readily available with the IPV D4, with it able to fire resistances down to 0.15 ohm and also outcome power up to 80W properly. Temperature level control followers have the capacity to make use of Ni200, Titanium and SS304 coils utilizing the dedicated modes located on the IPV D4, and a custom-made TCR input allows you to make use of other kinds of cable in TC by inputting the pertinent coefficients. Ergonomically the IPV D4 is a beautiful little small type element gadget with around as much power as you can get from a solitary 18650 device, I can not assist yet assume that there are a pair of attributes that ...
1. First choose your target victim, the thing that really angers you. Simply click the arrows till you get the object you want to purge, and then click on the text below "Choose your victim".. 2. Next choose your weapon; just click on one of the 4 deadly weapons. What would be the best tool for the job? Then click on "use weapon". 3. Now youre all set to smash away, let fly until your arm drops off or you decide to click the final death blow! Dont click too quick though as there is a weekly prize for topping the leaderboard!. 4. Once you have vented your anger you can deliver your Death Blow and purge your subject....only then will you find out if you are an instant winner or born loser.. ...
It appeared Rambos owners had gifted him a houseplant. Remi edged his eye over the back of the two-seater to watch as Rambo hovered past the street level flat to which Remis owners had relocated, clutching a plant. Rambo was the third bot to hover past that morning, and Remi had been expecting him to stop in and enquire if Remi himself were ready to depart. Rambo preferred company, especially at important events like a purge.. Perhaps Rambos apprehension in regard to Remis new location overrode his preference. Remis owners had been evicted from their previous flat; they were nothing but slumkins. Remi took satisfaction in the fact that they would not be able to replace him with a newer model after the purge. Truth be told, they had little use for a Zoombot, whether old or new. At least they had not been the ones to name him. A stray cat had "followed them home from the park" last month; they called her Mr. Kittywitty even though she was a female.. Mr. Kittywitty was too good for them. They ...
People often ask their physicians what they can do to prevent cancers. Various supplements and unorthodox treatments to clean out the system and purge toxins are promoted by convincing arguments as a way to improve health ...
Bulimic behavior has two phases: the binge and the purge. The Binge Although there are certainly individual variations, a binge is defined as the rapid
Multiple Reflection HATR with ZnSe Trough and ZnSe Flat Plate includes HATR base optics, ZnSe trough plate, ZnSe flat plate, HATR pressure clamp, HATR powder press, volatiles cover, purge tubes, and spectrometer base mount.
Whether its your first time thinking about protecting your skin from pollution, or youre a skincare expert looking for top-quality products, Nutricentials is the range for you.
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
Article The Analysis of BTEX and MTBE Using Specially Modified Purge Traps. The existence of underground storage tanks containing gasoline and other petroleum products has facilitated the need for routine testing to determine if there has been any le...
JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our scientific video articles.
If an update is available there will be a message indicating this and a button to press. Which update youll see depends on the setting for Update Server and caching. See options for Joomla! Update component. The first option shows the latest update of the major release in use. The second option shows the latest update of the latest major. Caching may cause not detecting an available update, purge cache.. ...
Near-record numbers of families are coming home, in some cases reviving resentments created by bloody purges that carved Iraq into archipelagos of Sunnis, Shiites and Kurds.

Bone Marrow Processing and Purging: a Practical Guide, 1st Edition (Hardback) - RoutledgeBone Marrow Processing and Purging: a Practical Guide, 1st Edition (Hardback) - Routledge

A Practical Guide provides an up-to-date practical guide to the major ex vivo procedures associated with bone marrow ... Bone Marrow Processing With the Haemonetics V50 Plus (MaryLynne Hartl). BONE MARROW EVALUATION. Bone Marrow Cell Counting: ... Regulatory Aspects of Bone Marrow Processing and Purging (Curtis L. Scribner). Quality Control in Bone Marrow Processing ( ... Monoclonal Antibodies for Ex Vivo Treatment of Bone Marrow (Derwood Pamphilon). AUTOLOGOUS BONE MARROW PURGING. The Use of 4-HC ...
more infohttps://www.routledge.com/Bone-Marrow-Processing-and-Purging-a-Practical-Guide/Gee/p/book/9780849364020

Evaluation of the silicon phthalocyanine Pc 4 for photodynamic bone marrow purgingEvaluation of the silicon phthalocyanine Pc 4 for photodynamic bone marrow purging

... ... "Evaluation of the silicon phthalocyanine Pc 4 for photodynamic bone marrow purging," J. Biomed. Opt. 3(3) (1 July 1998) Include ... "Evaluation of the silicon phthalocyanine Pc 4 for photodynamic bone marrow purging," Journal of Biomedical Optics 3(3), (1 July ... phthalocyanine Pc 4 was tested as a photosensitizer for the selective photoinactivation of malignant cells in bone marrow ...
more infohttps://www.spiedigitallibrary.org/journals/Journal-of-Biomedical-Optics/volume-3/issue-3/0000/Evaluation-of-the-silicon-phthalocyanine-Pc-4-for-photodynamic-bone/10.1117/1.429855.short

The effect of PIXY-321 on 4-hydroperoxycyclophosphamide purged and CD34+ positively selected bone marrow. - Semantic ScholarThe effect of PIXY-321 on 4-hydroperoxycyclophosphamide purged and CD34+ positively selected bone marrow. - Semantic Scholar

The effect of PIXY-321 on 4-hydroperoxycyclophosphamide purged and CD34+ positively selected bone marrow. by Lisa Hami et al. ... The effect of PIXY-321 on 4-hydroperoxycyclophosphamide purged and CD34+ positively selected bone marrow.. *. Lisa Hami, ...
more infohttps://www.semanticscholar.org/paper/The-effect-of-PIXY-321-on-purged-and-CD34%2B-selected-Hami-Shpall/358e9901329bc200707018d1f41ae401086e11c5

Effect of molecular structure on the performance of triarylmethane dyes as therapeutic agents for photochemical purging of...Effect of molecular structure on the performance of triarylmethane dyes as therapeutic agents for photochemical purging of...

... the development of novel purging protocols to promote selective elimination of residual tumor cells from autologous bone marrow ... the development of novel purging protocols to promote selective elimination of residual tumor cells from autologous bone marrow ... the development of novel purging protocols to promote selective elimination of residual tumor cells from autologous bone marrow ... the development of novel purging protocols to promote selective elimination of residual tumor cells from autologous bone marrow ...
more infohttps://creighton.pure.elsevier.com/en/publications/effect-of-molecular-structure-on-the-performance-of-triarylmethan

Autologous bone marrow transplantation for acute myelocytic leukemia in first remission: a European survey of the role of...Autologous bone marrow transplantation for acute myelocytic leukemia in first remission: a European survey of the role of...

Sixty-nine patients received autologous marrow purged in vitro with mafosfamide, and 194 received unpurged marrow. The median ... Autologous bone marrow transplantation for acute myelocytic leukemia in first remission: a European survey of the role of ... We conclude that marrow purging with mafosfamide may be valuable for patients autografted early in first CR.. This is a service ... marrow purging. Gorin NC, Aegerter P, Auvert B, et al.. Abstract:. We analyzed data from 263 patients with acute myelocytic ...
more infohttp://imsdd.meb.uni-bonn.de/cgi-bin/mycite?ExtRef=MEDL/90227228/PMID/2328313

Autologous bone marrow transplantation for acute myelocytic leukemia in first remission: a European survey of the role of...Autologous bone marrow transplantation for acute myelocytic leukemia in first remission: a European survey of the role of...

Sixty-nine patients received autologous marrow purged in vitro with mafosfamide, and 194 received unpurged marrow. The median ... 1987 at one of 34 centers in the European Bone Marrow Transplant Group. The median age of patients was 30 years (range, 1 to 65 ... We conclude that marrow purging with mafosfamide may be valuable for patients autografted early in first CR. ... and the probability of relapse was lower in recipients of purged than of unpurged marrow (63% versus 34%, P = .05 and 23% ...
more infohttps://www.semanticscholar.org/paper/Autologous-bone-marrow-transplantation-for-acute-in-Gorin-Aegerter/6e10d7de6987c4d99fc269cef9cd8fbe9f99efeb

Intra-coronary Infusion of Bone Marrow Derived Autologous CD34+ Selected Cells in Patients With Acute Myocardial InfarctionIntra-coronary Infusion of Bone Marrow Derived Autologous CD34+ Selected Cells in Patients With Acute Myocardial Infarction

Bone Marrow Purging. Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ... Bone Marrow Neoplasms. Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow ... Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION. ... BONE MARROW PURGING) of patients who are to undergo autologous bone marrow transplantation. ...
more infohttps://www.bioportfolio.com/resources/trial/108249/Intra-coronary-Infusion-of-Bone-Marrow-Derived-Autologous-CD34-Selected-Cells-in.html

Photodynamic therapy - WikipediaPhotodynamic therapy - Wikipedia

Mulroney, CM; S Gluck; AD Ho (1994). "The use of photodynamic therapy in bone marrow purging". Semin Oncol. 21 (6 Suppl 15): 24 ... pathogens present in samples of blood and bone marrow can be decontaminated before the samples are used further for ... "Photothermal ablation of bone metastasis of breast cancer using PEGylated multi-walled carbon nanotubes". Sci Rep. 5: 11709. ...
more infohttps://en.wikipedia.org/wiki/Photodynamic_therapy

Stem Cells and DevelopmentStem Cells and Development

Bone Marrow Purging and Processing: A Practical Guide. (1991). CRC Press, Boca Raton, FL. ... bone marrow progenitor cell processing, and bone marrow transplantation. Processing of these papers will be expedited, and ... STEM CELLS AND DEVELOPMENT welcomes papers covering widely diverse aspects of hematology, bone marrow transplantation, immune ... 1970). Allogeneic marrow engraftment following whole body irradiation in a patient with leukemia. Blood 35:741-750. 2. Shadduck ...
more infohttp://www.liebertpub.com/archpolicy/stem-cells-and-development/125/

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of...Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of...

Quantitative assays for human hemopoietic progenitor cellsPERIOD! Bone Marrow Processing and Purging: A Practical Guide. FL. ... Bone marrow (BM) was obtained from the femurs and tibias of BALB/c mice and used as a source of hematopoietic progenitor cells ... Infusion of VEGF was associated with inhibition of the activity of the transcription factor NF-κB in bone marrow progenitor ... Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and ...
more infohttp://www.bloodjournal.org/content/92/11/4150?ijkey=bbecb0adf177b009e8dc10639b87ca4fe47d5fdc&keytype2=tf_ipsecsha&sso-checked=true

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of...Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of...

Quantitative assays for human hemopoietic progenitor cellsPERIOD! Bone Marrow Processing and Purging: A Practical Guide. FL. ... Bone marrow (BM) was obtained from the femurs and tibias of BALB/c mice and used as a source of hematopoietic progenitor cells ... Infusion of VEGF was associated with inhibition of the activity of the transcription factor NF-κB in bone marrow progenitor ... Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and ...
more infohttp://www.bloodjournal.org/content/92/11/4150?ijkey=c67ab754584dd5c4029e722daf3f7b30d4d97144&keytype2=tf_ipsecsha&sso-checked=true

Patent US6642018 - Method for inducing a response in one or more targeted cells - Google PatentsPatent US6642018 - Method for inducing a response in one or more targeted cells - Google Patents

Gee, Adrian P.; Part 5: Autologous Bone Marrow Purging; Bone Marrow Processing and Purging; pp. 248-328 (1991).. ... Lazarus, et al.; Does In Vitro Bone Marrow Purging Improve the Outcome after Autologous Bone Marrow Transplantation?; Journal ... PCR-positivity in harvested bone marrow predicts relapse after transplantation with autologous purged bone marrow in children ... Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B-cell lymphoma. N.E.J.Med. 325 ...
more infohttp://www.google.com/patents/US6642018?dq=6175559

Patent US7811570 - Method of affecting a function of or ablating a non-malignant cell - Google PatentsPatent US7811570 - Method of affecting a function of or ablating a non-malignant cell - Google Patents

Meyer et al., "Streptavidin-Biotin Immunotoxins: A new Approach to Purging Bone Marrow", Exp. Hematol. 19:710-713 (1991).. ... Six weeks later, the patient has renewed bone marrow function and an MN3-Fab′ (Tc-99m) bone marrow scan shows good bone marrow ... Bone Marrow Ablation and Cancer Therapy. A middle-age woman with advanced breast cancer, including bone and bone marrow ... such as in bone marrow ablation with antibodies against bone marrow cells of particular stages of development and ...
more infohttp://www.google.com/patents/US7811570?dq=5998925

Use of CD33 monoclonal antibodies in bone marrow transplantation for acute myeloid leukemia.<...Use of CD33 monoclonal antibodies in bone marrow transplantation for acute myeloid leukemia.<...

Robertson M, Roy DC, Stone RM, Ritz J. Use of CD33 monoclonal antibodies in bone marrow transplantation for acute myeloid ... Robertson, M., Roy, D. C., Stone, R. M., & Ritz, J. (1994). Use of CD33 monoclonal antibodies in bone marrow transplantation ... Use of CD33 monoclonal antibodies in bone marrow transplantation for acute myeloid leukemia. / Robertson, Michael; Roy, D. C.; ... Robertson, M, Roy, DC, Stone, RM & Ritz, J 1994, Use of CD33 monoclonal antibodies in bone marrow transplantation for acute ...
more infohttps://indiana.pure.elsevier.com/en/publications/use-of-cd33-monoclonal-antibodies-in-bone-marrow-transplantation-

Patent WO1995008350A1 - REGULATION OF bcl-2 GENE EXPRESSION - Google PatentsPatent WO1995008350A1 - REGULATION OF bcl-2 GENE EXPRESSION - Google Patents

The patient can then be rescued by reinfusion of their own bone marrow cells, but only if that marrow has been "purged" of ... The anticode oligomers may also be useful for ex vivo bone marrow purging. Normally, the amounts of conventional cancer ... Alternatively, large amounts of bone marrow can be surgically extracted from the patient and stored in vitro , while the ... The claimed anticode oligomers could be used to remove residual malignant cells from the bone marrow. ...
more infohttp://www.google.com.au/patents/WO1995008350A1?cl=en

High-Dose RAIT May Improve Prognosis in Relapsed NHL Patients | Cancer Network | The Oncology JournalHigh-Dose RAIT May Improve Prognosis in Relapsed NHL Patients | Cancer Network | The Oncology Journal

Bone marrow was purged after removal and cryo-preserved. for reinfusion. Escalating doses of 131I-B1 were administered. ... Bone marrow transplantation (BMT) with total body irradiation. and chemotherapy has been found to be curative in fewer than ...
more infohttp://www.cancernetwork.com/articles/high-dose-rait-may-improve-prognosis-relapsed-nhl-patients

Radiation Therapy for Cancer Treatment | Sky Ridge Medical CenterRadiation Therapy for Cancer Treatment | Sky Ridge Medical Center

In addition, PDT is used for bone marrow purging. Bone marrow used for autologous transplantation must be relatively free of ... If large areas of active bone marrow are treated with radiation therapy, a decrease in bone marrow function occurs. Such ... Biologic Therapies Bone Marrow Transplant Chemotherapy Hormonal Therapy Managing Side Effects Radiation Surgery ... Before transplantation, the harvested marrow is often treated with PDT in a process known as "purging" to get rid of cancer ...
more infohttps://skyridgemedcenter.com/hl/?/32789/Bone-Marrow-Transplantation--BMT--for-Cancer-Treatment~Radiation

WO1990005445A1 - Antisense oligonucleotides to c-myb proto-oncogene and uses thereof 
        - Google PatentsWO1990005445A1 - Antisense oligonucleotides to c-myb proto-oncogene and uses thereof - Google Patents

They are particularly useful as bone marrow purging agents. ... Bone Marrow Purging Bone marrow transplantation is of two types ... a bone marrow purging agent is needed which effectively purges marrow of all malignant cells, while leaving normal marrow cells ... Example 8 Bone Marrow Purging with c-mvb. Antisense Oligonucleotide Bone marrow is harvested from the iliac bones of a donor ... According to a method for bone marrow purging, bone marrow is harvested from a donor by standard operating room procedures from ...
more infohttps://patents.google.com/patent/WO1990005445A1

George P. Canellos, MD - Dana-Farber Cancer Institute | Boston, MAGeorge P. Canellos, MD - Dana-Farber Cancer Institute | Boston, MA

Anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation for B-cell non-Hodgkins lymphoma: phenotypic ... Hematologic engraftment and immune reconstitution posttransplantation with anti-B1 purged autologous bone marrow. Blood. 1987 ... Bone Marrow Transplant. 1989 Jan; 4 Suppl 1:131-2.. View in: PubMed. Canellos GP. The role of alkylating agents in acute and ... Bone Marrow Transplant. 1989 Jan; 4 Suppl 1:46-7.. View in: PubMed. Ernst TJ, Rosenthal DS, Griffin JD, Canellos GP. Treatment ...
more infohttps://www.dana-farber.org/find-a-doctor/george-p-canellos/

Anti-CD7 antibody (Phycoerythrin) [B-F12] | AbcamAnti-CD7 antibody (Phycoerythrin) [B-F12] | Abcam

An effective immunomagnetic method for bone marrow purging in T cell malignancies.. Bone Marrow Transplant 9:319-23 (1992). ...
more infohttps://www.abcam.com/cd7-antibody-b-f12-phycoerythrin-ab27324.html

Immunology and Immunotherapy | SpringerLinkImmunology and Immunotherapy | SpringerLink

1994) Allogeneic versus autologous purged bone marrow transplantation for neuroblastoma: a report from the Childrens Cancer ... 1989) Removal of neuroblastoma cells from bone marrow by a direct monoclonal antibody rosetting technique. Bone Marrow ... 1994) Bone marrow transplantation for high risk neuroblastoma at the Childrens Hospital of Philadelphia: an update. Med ... Cheung IY, Cheung NKV (1997) Molecular detection of GAGE expression in peripheral blood and bone marrow: utility as a tumor ...
more infohttps://link.springer.com/chapter/10.1007/3-540-26616-X_14

Binding of the Aminothiol WR-1065 to Transcription Factors Influences Cellular Response to Anticancer Drugs | Journal of...Binding of the Aminothiol WR-1065 to Transcription Factors Influences Cellular Response to Anticancer Drugs | Journal of...

1995) Amifostine improves the antileukemic therapeutic index of mafosfamide: implications for bone marrow purging. Blood 86: ... while normal marrow progenitor cells were protected from cytotoxicity (Douay et al., 1995). ...
more infohttp://jpet.aspetjournals.org/content/297/3/1067?ijkey=c700b384ec09d0a49dddafb5537bc43fc6f9aaff&keytype2=tf_ipsecsha

Perfosfamide - WikipediaPerfosfamide - Wikipedia

Pharmacologic Purging of Bone Marrow. Chapter 20 in Thomas Hematopoietic Cell Transplantation, Volume 457. Eds. Thomas E.D. et ... Perfosfamide was used experimentally by oncologists in the 1980s for use in bone marrow transplant procedures for treatment of ... Scios Nova may purge Pergamid after FDA setback. Nature Biotechology. April 1993 11(4):439 doi 10.1038/nbt0493-439 The Pink ... "purge" a patients own (autologous) collected hematopoietic stem cells of any malignant cells it may still contain at the time ...
more infohttps://en.wikipedia.org/wiki/Perfosfamide

US5945337A - Method for culturing CD34+ cells in a serum-free medium 
        - Google PatentsUS5945337A - Method for culturing CD34+ cells in a serum-free medium - Google Patents

A serum-free medium which supports the proliferation and differentiation of CD34 + cells purified from normal bone marrow, ... The "purged" bone marrow is then transplanted back into the patient. The media of the present invention is suitable for storing ... Such a medium will allow the potential to store small amounts of bone marrow or subsets of the bone marrow cell population ( ... Bioreactor expansion of human adult bone marrow‐derived mesenchymal stem cells. US5576207A (en) 1996-11-19. Method of expanding ...
more infohttps://patents.google.com/patent/US5945337

State of the Art in Gene Therapy | SpringerLinkState of the Art in Gene Therapy | SpringerLink

... promoter-based conditionally replicative adenovirus for treatment of pediatric solid tumors and bone marrow tumor purging. ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4757-3718-9_15
  • We analyzed data from 263 patients with acute myelocytic leukemia (AML) autografted in first remission (CR) during the period from January, 1982 to January, 1987 at one of 34 centers in the European Bone Marrow Transplant Group. (uni-bonn.de)
  • It was added to the tissue after it had been taken from the donor but before the tissue was administered to the patient to "purge" lymphocytes in order to prevent Graft Versus Host Disease, which results from donor lymphocytes attacking normal host cells and tissues, and to "purge" a patient's own (autologous) collected hematopoietic stem cells of any malignant cells it may still contain at the time of harvesting. (wikipedia.org)
  • In 1989 Nova Pharmaceutical took over development of the compound and in 1992, it submitted a new drug application to the FDA for using perfosamide to purge malignant cells in transplants for the treatment of acute myeloid leukemia. (wikipedia.org)
  • For patients with standard risk AML in CR1 autografted after TBI (n = 107), the leukemia-free survival (LFS) was higher, and the probability of relapse was lower in recipients of purged than of unpurged marrow (63% versus 34%, P = .05 and 23% versus 55%, relative risk 0.34, P = .005, respectively). (uni-bonn.de)
  • The treatment was discovered in people with leukaemia who also happened to have MS. Leukaemia is a cancer of the immune cells, and can be treated by first extracting some of a person's bone marrow cells and then killing all the immune cells that remain in the body with toxic chemotherapy. (newscientist.com)
  • The superior results of purging were most obvious in patients autografted within 6 months of achieving CR (probability of relapse, 20% versus 61%, P = .01). (uni-bonn.de)
  • Jan F. Keij, Yajuan Jiang, Damianos A. Sotiropoulos, Ehud Ben-Hur, Jan W. M. Visser, "Evaluation of the silicon phthalocyanine Pc 4 for photodynamic bone marrow purging," J. Biomed. (spiedigitallibrary.org)
  • However, many media are not suitable for culturing normal bone marrow cells, especially CD34 + cells because of their high proliferative capability. (google.com)
  • They are particularly useful as bone marrow purging agents. (google.com)
  • The initial rationale for the use of IMiDs in MM was their known antiangiogenic activity, considered the primary role of increased angiogenesis in MM bone marrow [ 9 , 10 ]. (hindawi.com)