Progenitor cells from which all blood cells derive.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Removal of bone marrow and evaluation of its histologic picture.
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
A cytologic technique for measuring the functional capacity of stem cells by assaying their activity.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Bone loss due to osteoclastic activity.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.
Transplantation of an individual's own tissue from one site to another site.
Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
A particular zone of tissue composed of a specialized microenvironment where stem cells are retained in a undifferentiated, self-renewable state.
An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.
Tumors or cancer located in bone tissue or specific BONES.
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis and is a growth factor for a number of cell types including the MAST CELLS and the MELANOCYTES in addition to the HEMATOPOIETIC STEM CELLS.
Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.
Diseases of BONES.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Cells with high proliferative and self renewal capacities derived from adults.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Elements of limited time intervals, contributing to particular results or situations.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)
An encapsulated lymphatic organ through which venous blood filters.
The process of bone formation. Histogenesis of bone including ossification.
Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
The blood-making organs and tissues, principally the bone marrow and lymph nodes.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
Very large BONE MARROW CELLS which release mature BLOOD PLATELETS.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
Formation of LYMPHOCYTES and PLASMA CELLS from the lymphoid stem cells which develop from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW. These lymphoid stem cells differentiate into T-LYMPHOCYTES; B-LYMPHOCYTES; PLASMA CELLS; or NK-cells (KILLER CELLS, NATURAL) depending on the organ or tissues (LYMPHOID TISSUE) to which they migrate.
A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The cells found in the body fluid circulating throughout the CARDIOVASCULAR SYSTEM.
Parts of plants that usually grow vertically upwards towards the light and support the leaves, buds, and reproductive structures. (From Concise Dictionary of Biology, 1990)
Stem cells derived from HEMATOPOIETIC STEM CELLS. Derived from these myeloid progenitor cells are the MEGAKARYOCYTES; ERYTHROID CELLS; MYELOID CELLS; and some DENDRITIC CELLS.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
A strain of non-obese diabetic mice developed in Japan that has been widely studied as a model for T-cell-dependent autoimmune insulin-dependent diabetes mellitus in which insulitis is a major histopathologic feature, and in which genetic susceptibility is strongly MHC-linked.
A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.
Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.
The formation and development of blood cells outside the BONE MARROW, as in the SPLEEN; LIVER; or LYMPH NODES.
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).
The grafting of bone from a donor site to a recipient site.
One of a pair of excretory organs (mesonephroi) which grows caudally to the first pair (PRONEPHROI) during development. Mesonephroi are the permanent kidneys in adult amphibians and fish. In higher vertebrates, proneprhoi and most of mesonephroi degenerate with the appearance of metanephroi. The remaining ducts become WOLFFIAN DUCTS.
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
Disorders of the blood and blood forming tissues.
The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A group of lymphocyte surface antigens located on mouse LYMPHOCYTES. Specific Ly antigens are useful markers for distinguishing subpopulations of lymphocytes.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
Formation of MYELOID CELLS from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via MYELOID STEM CELLS. Myelopoiesis generally refers to the production of leukocytes in blood, such as MONOCYTES and GRANULOCYTES. This process also produces precursor cells for MACROPHAGE and DENDRITIC CELLS found in the lymphoid tissue.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.
The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from different individuals. This contrasts with MOSAICISM in which the different cell populations are derived from a single individual.
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Cells that can give rise to cells of the three different GERM LAYERS.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow MEGAKARYOCYTES and their release of blood platelets. The process is called THROMBOPOIESIS.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
An individual that contains cell populations derived from different zygotes.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
"Bone Marrow (Hematopoietic) Stem Cells , stemcells.nih.gov". stemcells.nih.gov. Retrieved 2017-07-13. Sullivan, Kathleen E.; ... one finds that treatment with allogeneic hematopoietic stem cell transplantation, which are stem cells that bring about other ... Recurrent infections Microcephaly Growth retardation Bone-malformation Dysmorphic feature Urogenital malformations In terms of ...
1987). "Bone marrow transplantation in the treatment of alpha-mannosidosis". Disease in Childhood. 62 (10): 1044-1049. doi: ... 2004).Effective treatment of alpha-mannosidosis by allogeneic hematopoietic stem cell transplantation. J Pediatr, 144:569-573. ... Hematopoietic stem cell transplantation (HSCT) can be a treatment option for some patients, however the risk-benefit profile is ... The long-term forecast for the condition is poor.[2] There is generally a slow progression of neuromuscular and bone changes ...
All T cells originate from haematopoietic stem cells in the bone marrow. Haematopoietic progenitors (lymphoid progenitor cells ... T cells develop in the thymus, and B cells, in mammals, develop in the bone marrow in adults or the liver in fetuses." ... Schwarz BA, Bhandoola A (February 2006). "Trafficking from the bone marrow to the thymus: a prerequisite for thymopoiesis". ... bone marrow transplantation, and HIV-1 infection". Annu. Rev. Immunol. 18: 529-60. doi:10.1146/annurev.immunol.18.1.529. PMID ...
Hematopoietic stem cells (HSCs), derived from bone marrow or blood, are cells with the abilities to self-renew and to ... Wilson A, Trumpp A (2006). "Bone-marrow haematopoietic stem-cell niches". Nature Immunology. 6 (2): 93-106. doi:10.1038/nri1779 ... Annually an estimated 18,000 patients require potentially life-saving bone marrow transplants in the USA. For a long time, bone ... and peripheral blood stem cells (PBSCs) has been increasing. In comparison with bone marrow-derived HSC recipients, PBSC ...
... "bone homing receptor", directing migration of human hematopoietic stem cells and mesenchymal stem cells to bone marrow.[11] Ex ... Sackstein R (May 2004). "The bone marrow is akin to skin: HCELL and the biology of hematopoietic stem cell homing". The Journal ... The HCELL glycoform was originally discovered on human hematopoietic stem cells and leukemic blasts,[7][10][11][12] and was ... Li F, Tiede B, Massagué J, Kang Y (Jan 2007). "Beyond tumorigenesis: cancer stem cells in metastasis". Cell Research. 17 (1): 3 ...
Haematopoietic stem cells (HSCs) reside in the medulla of the bone (bone marrow) and have the unique ability to give rise to ... Figure 24-8: Formation of differentiated blood cells from hematopoietic stem cells in the bone marrow. ISBN 0-7167-3136-3 - via ... For the stem cells and other undifferentiated blood cells in the bone marrow, the determination is generally explained by the ... During fetal development, since bones and thus the bone marrow develop later, the liver functions as the main haematopoetic ...
... where they coexist with the recipient's stem cells. The bone marrow stem cells give rise to cells of all hematopoietic lineages ... The existence of donor stem cells in the recipient's bone marrow causes donor reactive T cells to be considered self and ... Donor stem cells are introduced into the bone marrow of the recipient, ... A proposed strategy to avoid cellular rejection is to induce donor non-responsiveness using hematopoietic chimerism. ...
He demonstrated that erythropoiesis and leukopoiesis formulate in the bone marrow. "Ernst Neumann postulated a common stem cell ... for all hematopoietic cells". In 2007, Zech et al. wrote: "The beginning of Stem Cell research can be dated back to Ernst ... 15 (1967) 8 Tavassoli, M.: Bone Marrow. Structure and Funktion. Alan R.Liss. Inc. New York, 1983 Tavassoli, M.: Bone Marrow. ... you find the first announcement of the bone marrow as blood forming organ. Translation: In the so-called red bone marrow of man ...
Domen, J., Wagers, A., & Weissman, I. "Bone Marrow (Hematopoietic) Stem Cells." April 19, 2017, from https://stemcells.nih.gov/ ... Hematopoietic stem cell (HSC) transplantation is another treatment for lysosomal storage diseases. HSCs are derived from bone- ... and bone-marrow derived stem cell transplantation.[1] ERT was developed in 1964 by Christian de Duve and Roscoe Brady. Leading ... marrow. These cells have the ability to mature into the many cell types that comprise blood, including red blood cells, ...
Morrison SJ, Scadden DT (January 2014). "The bone marrow niche for haematopoietic stem cells". Nature. 505 (7483): 327-34. ... begins from a haematopoietic stem cells. These are multipotent cells that reside in the bone marrow niche and have the ability ... doi:10.1016/j.stem.2012.01.006. PMID 22305562. Wahed A, Dasgupta A (2015-01-01). "Chapter 2 - Bone Marrow Examination and ... These are secreted by other haematopoietic cells in the bone marrow or at the site of inflammation as well as epithelial and ...
... haematopoietic) stem cells. Blood-forming stem cells are present in the bone marrow in very specific microenvironments. ... Morrison, Sean J.; Scadden, David T. (2014). "The bone marrow niche for haematopoietic stem cells". Nature. 505 (7483): 327-334 ... 2008). "Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice ... 2015). "Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential". Cell. 160 (1-2): 269- ...
Morrison, S. J; Scadden, D. T (2014). "The bone marrow niche for haematopoietic stem cells". Nature. 505 (7483): 327-334. doi: ...
hematopoietic system G-CSF is also a potent inducer of hematopoietic stem cell (HSC) mobilization from the bone marrow into the ... "G-CSF-primed bone marrow as a source of stem cells for allografting: revisiting the concept". Bone Marrow Transplantation. 50 ( ... Tay J, Levesque JP, Winkler IG (December 2016). "Cellular players of hematopoietic stem cell mobilization in the bone marrow ... number of hematopoietic stem cells in the blood of the donor before collection by leukapheresis for use in hematopoietic stem ...
... s are ultimately derived from bone marrow hematopoietic progenitor cells [see hematopoietic stem cell, hematopoiesis] ... circulating CD34+ hematopoietic stem cells (HSC) reside in bone marrow. They produce precursors of T lymphocytes, which seed ... Thymocytes are produced as stem cells in the bone marrow and reach the thymus via the blood. Thymopoiesis describes the process ... PMID 15557139.CS1 maint: uses authors parameter (link) Schwarz BA, Bhandoola A. Trafficking from the bone marrow to the thymus ...
... differential admixture and its potential impact on hematopoietic stem cell transplantation". Bone Marrow Research. 2012: 1-13. ... "Copy number variation may stem from replication misstep". EurekAlert!. 27 December 2007. Retrieved 5 September 2011.. ...
... s are derived from hematopoietic stem cell precursor cells in the bone marrow. They are produced primarily by the ... The primary treatment for CAMT is bone marrow transplantation. Bone marrow/stem cell transplant is the only remedy for this ... and bone marrow. These multipotent stem cells live in the marrow sinusoids and are capable of producing all types of blood ... "Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis ...
... s develop from hematopoietic stem cells (HSCs) that originate from bone marrow. HSCs first differentiate into multipotent ... In mammals, B cells mature in the bone marrow, which is at the core of most bones. In birds, B cells mature in the bursa of ... After B cells mature in the bone marrow, they migrate through the blood to SLOs, which receive a constant supply of antigen ... B cells undergo two types of selection while developing in the bone marrow to ensure proper development, both involving B cell ...
"Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation". Bone Marrow ... in bone marrow, to immature neutrophils". Comptes Rendus de l'Académie des Sciences, Série III. 324 (12): 1125-32. doi:10.1016/ ... Hollenbeck ST, Sakakibara K, Faries PL, Workhu B, Liu B, Kent KC (August 2004). "Stem cell factor and c-kit are expressed by ... Hiraoka A, Yano Ki K, Kagami N, Takeshige K, Mio H, Anazawa H, Sugimoto S (2002). "Stem cell growth factor: in situ ...
... s are born from hematopoietic stem cells, found in the bone marrow. Then, developing T cells migrate to the thymus gland ... All T cells originate from c-kit+Sca1+ haematopoietic stem cells (HSC) which reside in the bone marrow. In some cases, the ... T cells develop [mature] in the thymus, and B cells, in mammals, develop [mature] in the bone marrow in adults or the liver in ... Hematopoietic Stem Cells , stemcells.nih.gov". stemcells.nih.gov. Retrieved 2020-11-21. Alberts B, Johnson A, Lewis J, Raff M, ...
Tumors metastasize to particular organs due to the migration of hematopoietic bone marrow cells expressing VEGFR1 (vascular ... Kaplan, Rosandra (2016-03-16). "Activation of Hematopoietic Stem/Progenitor Cells Promotes Immunosuppression Within the Pre- ... Kaplan, Rosandra (2005-12-08). "VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche". ... Tumor cells release factors that cause bone cells to resorb and therefore increase the rate of metastasis. Bone is conducive to ...
For a long time, the most efficient approach had been to use bone marrow graft, or hematopoietic stem cell transplantation. ... Because of all these reasons, bone marrow grafts or hematopoietic stem cell transplantation have seen a decrease in their ... long term follow-up on patients undergone to hematopoietic stem cell transplantation, Minerva Pediatr. 2013 Oct;65(5):487-96. ...
June 2018). "Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche". Nature Medicine. ... Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery. npj Regen Med ...
EMH can occur during adulthood when physiologic hematopoiesis can't work properly in the bone marrow and the hematopoietic stem ... pulmonary megakaryocytes migrate out of lungs into the bone marrow, where they help to replenish the depleted bone marrow ... Finally, once the bone marrow has developed, they migrate there. They can also migrate to the spleen and lymph nodes where ... The cause of pathologic EMH can be one of many hematological diseases, such as myelofibrosis, or as a result of bone marrow ...
"Bone Marrow Transplantation. 31 (12): 1704105. doi:10.1038/sj.bmt.1704105.. *^ Fine, Jo-David; Manes, Becky; Frangoul, Haydar ( ... "Outcome of 27 patients with Hurler's syndrome transplanted from either related or unrelated haematopoietic stem cell sources". ... As of 2008 clinical research at the University of Minnesota has included a bone marrow transplant to a 2-year-old child who is ... at least four patients have died in the course of either preparation for or institution of bone marrow transplantation for ...
hematopoietic system. G-CSF is also a potent inducer of hematopoietic stem cell (HSC) mobilization from the bone marrow into ... "G-CSF-primed bone marrow as a source of stem cells for allografting: revisiting the concept". Bone Marrow Transplantation. 50 ( ... Tay J, Levesque JP, Winkler IG (December 2016). "Cellular players of hematopoietic stem cell mobilization in the bone marrow ... Stem cell transplantsEdit. G-CSF may also be given to the receiver in hematopoietic stem cell transplantation, to compensate ...
Fertility Issues Following Hematopoietic Stem Cell Transplantation. Expert Rev Hematol. 2013, 6 (4): 375-388. PMID 23991924. ... Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey. Lancet. 2001, 358 (9278): 271 ... Fertility Issues Following Hematopoietic Stem Cell Transplantation. Expert Rev Hematol. 2013, 6 (4): 375-388. PMID 23991924. ... 骨塑型蛋白受體 1B(英语:Bone morphogenetic protein receptor 1B). 卵巢功能障礙、高促性腺激素性性腺功能
"Stem Cell or Bone Marrow Transplant Side Effects". www.cancer.org. Retrieved 2020-09-01. Goker H, Haznedaroglu IC, Chao NJ ( ... Prior to haematopoietic stem cell transplantation, radiation or chemotherapy results in damage and activation of host tissues, ... International Bone Marrow Transplant Registry". Bone Marrow Transplantation. 24 (3): 283-7. doi:10.1038/sj.bmt.1701899. PMID ... GvHD is commonly associated with bone marrow transplants and stem cell transplants. White blood cells of the donor's immune ...
These cell populations are endothelial progenitor cells, hematopoietic stem cells and mesenchymal stem cells. Adipose tissue ... Bone marrow contains different cell populations, which exhibit excellent plasticity toward cardiogenic and endothelial cells. ... To resume, stem cells and delivery routes aforementioned are suitable for cardiomyoplasty as demonstrated safe with some degree ... To date, no hydrogel matrix is FDA-approved for stem cell therapy use despite a large number of biomaterials currently ...
"In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow". Nature Protocols. 6 (1 ... Multiphoton microscopy also allows visualizing cells located underneath bone tissues such as cells of the bone marrow. The ... "T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments". Nature. 538 (7626): 518-522. doi: ... This is useful for many areas of research including immunology and stem cell research. High quality of modern microscopes and ...
August 2013). "Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56". Leukemia. 27 (8 ... Studies in the hematopoietic system disclosed that during endothelial to hematopoietic stem cell transition, Gpr56 is a ... January 2015). "Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for ... GPR56 is expressed in liver, muscle, tendon, neural, and cytotoxic lymphoid cells in human as well as in hematopoietic ...
... bone marrow transplantation, and HIV-1 infection. Annual Review of Immunology. 2000, 18: 529-560. ISSN 0732-0582. PMID 10837068 ... and II restricted cytotoxic activity associates with acute B lymphoblastic leukemia relapse after allogeneic hematopoietic stem ... T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation. Blood Cancer ...
Bone-marrow Arall. Ffeiliau perthnasol ar Gomin Wicimedia. Mer esgyrn yw'r meinwe hyblyg tu mewn asgwrn. Gyda bodau dynol, mae ... Y ddau fath o mer esgyrn yw "mer coch" (Lladin: medulla ossium rubra), sy'n cynnwys yn bennaf meinwe hematopoietic [celloedd ... "Antibody Transforms Stem Cells Directly Into Brain Cells". Science Daily. 22 April 2013. http://www.sciencedaily.com/releases/ ... Gall y gydadwaith rhwng y gwahanol celloedd yma a'u ffactorau lleol maent yn creu cael effaith ar gelloedd hematopoietic o fewn ...
"Bone Marrow Transplant" redirects here. For the journal abbreviated Bone Marrow Transplant, see Bone Marrow Transplantation ( ... Wikimedia Commons has media related to Hematopoietic stem cell transplantation.. *Bone marrow transplant - How it is performed ... Stem cell transplantation was pioneered using bone-marrow-derived stem cells by a team at the Fred Hutchinson Cancer Research ... Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived ...
"P-Selectin coated microtube for enrichment of CD34+ hematopoietic stem and progenitor cells from human bone marrow". Clin Chem ... 2006). "Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy". Stem ... stem cells in adult bone marrow and other tissues". Leukemia 21 (5): 860-7. PMID 17344915. ... "Bone Marrow Res 2012: 787414. PMC 3398573. PMID 22830032. *↑ William JB; Prabakaran, Rajamanickam; Ayyappan, Subbu (2011). " ...
Bone marrow. *Hematopoietic stem cell. Thymus. *Hassall's corpuscles. Secondary organs. Spleen. *Structure *Hilum ...
Hematopoietic stem cells (HSC), which provide the regulated lifelong supply of leukocyte progenitors that are in turn able to ... which is the organ essential for T-cell maturation following the migration of precursor cells from the bone marrow. This age- ... "Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice ... "Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells". Nature. 431 (7011): 997-1002 ...
All white blood cells are produced and derived from multipotent cells in the bone marrow known as hematopoietic stem cells. ... increase of production in bone marrow, increased release from storage in bone marrow, decreased attachment to veins and ... HSC=Hematopoietic stem cell, Progenitor=Progenitor cell, L-blast=Lymphoblast, Lymphocyte, Mo-blast=Monoblast, Monocyte, ... Miscellaneous - ECMO, kidney or bone marrow transplant, hemodialysis, kidney failure, severe burn, celiac disease, severe acute ...
"P-Selectin coated microtube for enrichment of CD34+ hematopoietic stem and progenitor cells from human bone marrow". Clin Chem ... Updated: 16 December 2013 Why Perform a Stem Cell Transplant?. *↑ Bone Marrow Transplantation and Peripheral Blood Stem Cell ... "Use of Bone Marrow derived Stem Cells in Patients with Cardiovascular Disorders". Journal of Stem Cells and Regenerative ... Bone Marrow Transplant». ucsfchildrenshospital.org.. *↑ Ed Kane. «Stem-cell therapy shows promise for horse soft-tissue injury ...
June 2008). "Stem cell transplantation for primary immunodeficiencies". Bone Marrow Transplant. 41 Suppl 2: S83-6. doi:10.1038/ ... Virus-specific T-Lymphocytes (VST) therapy is used for patients who have received hematopoietic stem cell transplantation that ... Bone marrow transplant may be possible for Severe Combined Immune Deficiency and other severe immunodeficiences. ...
KK Ballen, F Verter and J Kurtzberg Umbilical cord blood donation: public or private? Bone Marrow Transplantation (2015), 1-8 ... Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proceedings of the ... Increased migration of cord blood-derived CD34+ cells, as compared to bone marrow and mobilized peripheral blood CD34+ cells ... Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling ...
... but are the products of multipotent hematopoietic stem cells present in the bone marrow.[7] ... The bone marrow of a normal healthy adult produces more than 100 billion neutrophils per day, and more than 10 times that many ...
... inflammatory responses within the bone marrow are believed to foster many hematological diseases. The secretion of IL-6 by bone ... myelodysplastic syndrome and hematopoietic stem cell transplantantion. Lenalidomide is approved in nearly 70 countries, in ... July 1994). "Bone marrow angiogenesis and progression in multiple myeloma". Br. J. Haematol. 87 (3): 503-8. doi:10.1111/j.1365- ... They discovered increased bone marrow angiogenesis correlates with myeloma growth and supporting stromal cells are a ...
... marrow transplant. This allows more intensive chemotherapy to be given, and in addition the transplanted bone marrow may help ... Frei E, Kufe DW, Holland JF (2003). "Section 34: Hematopoietic System: Adult Acute Lymphocytic Leukemia: Evaluation of Minimal ... stem cell transplant, e.g. ... of marrow. Additional examination of the bone marrow by tests ... When a bone marrow sample is drawn, leukemic cells can be viewed under a microscope. Leukemic cells look like normal immature ...
... a hematopoietic stem cell transplant, accomplished through a umbilical cord blood or bone marrow transplant offers the only ... It contains 502 amino acids and is mainly expressed in hematopoietic cells (the cells in the bone marrow that develop into ... Often, leukemia may be suspected on the basis of low platelets and infections, and bone marrow biopsy may be performed. ... "Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome". Science. 341 (6148): 1233151. doi: ...
... derived from bone marrow resident hematopoietic stem cells). Developing T cells are referred to as thymocytes and are of ... During this stage, hematopoietic bone-marrow precursors migrate into the thymus. Normal development is dependent on the ... In the two lobes, hematopoietic precursors from the bone-marrow, referred to as thymocytes, mature into T cells. Once mature, T ... Schwarz, B. A.; Bhandoola, A. (2006). "Trafficking from the bone marrow to the thymus: a prerequisite for thymopoiesis". ...
... s are derived from stem cells residing in the bone marrow. The differentiation of these stem cells from pluripotent ... hematopoietic stem cell into granulocytes is termed granulopoiesis. Multiple intermediate cell types exist in this ... Basophils are one of the least abundant cells in bone marrow and blood (occurring at less than two percent of all cells). Like ... When an infection occurs, mature basophils will be released from the bone marrow and travel to the site of infection.[22] When ...
... including bone marrow or stem cell transplants), and/or growth factors.[43] ... Prior to the development of chemotherapy regimens and hematopoietic stem cell transplant, children were surviving a median ... Bone pain, joint pain (caused by the spread of "blast" cells to the surface of the bone or into the joint from the marrow ... A bone marrow biopsy provides conclusive proof of ALL, typically with ,20% of all cells being leukemic lymphoblasts.[27] A ...
Normally lymphoblasts are found in the bone marrow, but in acute lymphoblastic leukemia (ALL), lymphoblasts proliferate ... Hematopoietic stem cell. *Lymphoblast. *Prolymphocyte. This oncology article is a stub. You can help Wikipedia by expanding it. ...
... leads to replacement of the hematopoietic tissue of the bone marrow by connective tissue via collagen fibrosis. The decrease in ... In these cases, myelofibrosis occurs as a result of somatic evolution of the abnormal hematopoietic stem cell clone that caused ... A bone marrow biopsy will reveal collagen fibrosis, replacing the marrow that would normally occupy the space.[citation needed] ... Primary myelofibrosis (PMF) is a rare bone marrow blood cancer.[1] It is classified by the World Health Organization (WHO) as a ...
In very severe myelosuppression, which occurs in some regimens, almost all the bone marrow stem cells (cells that produce white ... Chemotherapy drugs are also used in conditioning regimens prior to bone marow transplant (hematopoietic stem cell transplant). ... Krumbhaar EB (1919). "Role of the blood and the bone marrow in certain forms of gas poisoning". JAMA. 72: 39-41. doi:10.1001/ ... Virtually all chemotherapeutic regimens can cause depression of the immune system, often by paralysing the bone marrow and ...
P-Selectin coated microtube for enrichment of CD34+ hematopoietic stem and progenitor cells from human bone marrow". Clin Chem ... Updated: 16 December 2013 Why Perform a Stem Cell Transplant? *↑ Bone Marrow Transplantation and Peripheral Blood Stem Cell ... Madhusankar N. „Use of Bone Marrow derived Stem Cells in Patients with Cardiovascular Disorders". Journal of Stem Cells and ... Bone Marrow Transplant". ucsfchildrenshospital.org.. *↑ Kane, Ed. "Stem-cell therapy shows promise for horse soft-tissue injury ...
... created a bone marrow registry, the Tzu Chi Bone Marrow Bank, in 1993 after a young follower of Cheng Yen was diagnosed ... Smith, Franklin O.; Reaman, Gregory H.; Racadio, Judy M. (26 November 2013). Hematopoietic Cell Transplantation in Children ... This registry became a division of the new Tzu Chi Stem Cells Center, which was founded to improve research and treatment ... the foundation created a bone marrow registry, an effort that eventually caused Taiwan to alter its bone marrow laws, and ...
City of Hope performed its 10,000th hematopoietic stem cell transplantation, which includes transplants of bone marrow, ... In 2017, City of Hope was planning a Bone Marrow Transplant Reunion Day and Survivors Day.[10] The hospital also participates ... "City of Hope Reaches Historic Treatment Milestone with 10,000th Bone Marrow Transplant". BusinessWire. 2011-01-13. Archived ... The center has performed 13,000 hematopoietic stem cell transplants as of 2016 with patient outcomes that consistently exceed ...
Non-hematopoietic mesenchymal cells ⇨ sarcoma. *Hematopoietic cells *Bone marrow-derived cells that normally mature in the ... Certain combinations of mutations in the given progenitor cell ultimately result in that cell (also called a cancer stem cell) ... Bone marrow-derived cells that normally mature in the lymphatic system ⇨ lymphoma ... A progenitor carcinoma stem cell can be formed from any of a number of oncogenic combinations of mutations in a totipotent cell ...
Additionally, no evidence has been found to support the placement of stem cells taken from bone marrow on the trachea as a way ... Hematopoietic and immune systems. *Myeloid *Myeloid immune system. *Lymphoid *Lymphoid immune system ... From 2008, operations have experimentally replaced tracheas, with those grown from stem cells, or with synthetic substitutes, ...
... serving to mobilize stem cells from the donor's bone marrow into the peripheral circulation. Fresh cells are infused to ... Donor's stem cells, which have been processed, will also accelerate functional recovery of recipient's hematopoietic stem cells ... No bone marrow disorder, high blood pressure, coronary heart disease, cardiopulmonary insufficiency, hematological disorder or ... as well as the challenge to find HLA-matched donors for conventional hematopoietic stem cell transplantation, Dr Huisheng Ai, ...
RBCs are formed in the red bone marrow from hematopoietic stem cells in a process known as erythropoiesis. In adults, about 2.4 ... They are produced and derived from multipotent cells in the bone marrow known as a hematopoietic stem cells. Leukocytes are ... Diagram showing the development of different blood cells from hematopoietic stem cells to mature cells. ... A blood cell, also called a hematopoietic cell, hemocyte, or hematocyte, is a cell produced through hematopoiesis and found ...
Also, some diseases related to hematopoietic system, such as aplastic anemia and complete bone marrow failure, are not ... "Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle". Cell Stem ... for stem cell dysfunction with aging. Hematopoietic stem cells (HSCs) regenerate the blood system throughout life and maintain ... and self-renewal of hematopoietic stem cells are favoring elements of stem cell pool maintenance while differentiation, ...
B cells and T cells are produced by stem cells in the bone marrow.[5] T cell progenitors then migrate from the bone marrow to ... B cells and T cells are derived from the same multipotent hematopoietic stem cells, and look identical to one another until ... Naive B and naive T cells, which have left the bone marrow or thymus and entered the lymphatic system, but have yet to ...
The hematopoietic stem cell (HSC) derived from adult bone marrow (BM) is commonly thought to have multilineage potential, ... Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells. Eliver Eid Bou Ghosn, Ryo Yamamoto ... Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells ... Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells ...
A similar population of DCs was present in human bone marrow. Ablation of conventional DCs (cDCs) results in hematopoietic stem ... in the bone marrow is shown. The number of KSL (. D. ) or CFU-C (. E. ) in bone marrow, blood, and spleen are shown. Data are ... Shown are the number of cDCs in the bone marrow, blood, and spleen (. n. = 5, 4, 4 and 6 mice per time point). (. B. -. E. ) ... Here, we show that murine bone marrow DCs are perivascular and have a type 2 conventional DC (cDC2) immunophenotype. RNA ...
... day program is designed for Registered Nurses and Nurse Practitioners caring for patients undergoing Hematopoietic Stem Cell ... day program is designed for Registered Nurses and Nurse Practitioners caring for patients undergoing Hematopoietic Stem Cell ...
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell ... reside in specialized environments within the bone marrow termed the hematopoietic niche. The majority of hematopoietic stem ... Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking. Jingzhu Zhang,1 Teerawit Supakorndej,1 ... Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood. 2010;116(23): ...
This glossary can help you to easily understand medical terms related to the article on Bone Marrow Transplantation ... Glossary for Bone Marrow or Hematopoietic Stem Cell Transplantation Do you wish to consult Oncologist for your problem? Ask ... Bone Marrow Transplantation - Animation. Animation and slides providing graphic explanation of Bone Marrow Transplantation (BMT ... Myelodysplastic syndromes are a group of bone marrow stem cell disorders marked by ineffective blood cell production and low ...
Title : Small Molecule Protection of Bone Marrow Hematopoietic Stem Cells. Descriptive Note : Technical Report,30 Sep 2015,29 ... Descriptors : stem cells , bone marrow , HEMATOPOIETIC SYSTEM formaldehyde , aldehydes , mass spectrometry , dna ...
... intracoronary transplantation of autologous bone marrow stem cells; mobilization of bone marrow stem-cells induced by G-CSF; ... Regulatory Systems in Bone Marrow for Hematopoietic Stem/Progenitor Cells Mobilization and Homing. P. Alvarez,1,2 E. Carrillo,1 ... Regulation of hematopoietic stem cell release, migration, and homing from the bone marrow (BM) and of the mobilization pathway ... For many decades, bone marrow (BM) transplantation was the only viable method for transplanting hematopoietic stem cells, ...
Allogeneic hematopoietic stem cell transplantation (HSCT) is a standard therapeutic intervention for hematological malignancies ... CRISPR/Cas9-modified hematopoietic stem cells-present and future perspectives for stem cell transplantation. Bone Marrow ... 25th anniversary of the first successful allogeneic bone marrow transplants. Bone Marrow Transplant. 1994;14:211-2. ... CRISPR/Cas9-modified hematopoietic stem cells-present and future perspectives for stem cell transplantation. *Alberto Daniel- ...
... with iduronidase in the peritransplant period affects outcome of hematopoietic stem cell transplantation (HSCT) for MPS IH. ... The patient population was heterogeneous in the choice of stem cell grafts (cord blood, bone marrow, peripheral blood stem ... Combination of enzyme replacement and hematopoietic stem cell transplantation as therapy for Hurler syndrome. Bone Marrow ... Outcome of second hematopoietic cell transplantation in Hurler syndrome. Bone Marrow Transplant 2002; 29: 491-496. ...
bone marrow;. HSC,. hematopoietic stem cells;. LT-HSC,. long-term repopulating HSC;. LSK,. Lin−ScaI+c-Kit+;. PB,. peripheral ... Adult hematopoietic stem cells (HSCs) exist in a relatively quiescent state in the bone marrow (BM) microenvironment to fulfill ... Adult hematopoietic stem cells (HSCs) exist in a relatively quiescent state in the bone marrow (BM) microenvironment to execute ... Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Linda Yang, Lei Wang ...
... cells are required for the homing of haematopoietic stem and progenitor cells. k, Bone marrow homing of haematopoietic ... Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.. Méndez-Ferrer S1, Michurina TV, Ferraro F, Mazloom ... The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear, with studies ... a-c, Flow cytometry characterization of bone marrow Nes-GFP+ cells; representative diagrams were obtained from bone marrow ...
JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow. Marie-Laure Arcangeli, Vincent Frontera, Florence ... Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2011;466(7308):829-834. ... In adult mammals, hematopoietic stem cells (HSCs) reside in the bone marrow (BM) and are maintained in a quiescent and ... Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. ...
... human bone marrow; hLin- HSC, human lineage-negative hematopoietic stem cell; HSC, hematopoietic stem cell; INL, inner nuclear ... Adult bone marrow is known to contain a population of hematopoietic stem cells (HSCs) that can be divided into lineage positive ... Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells. ... Cell preparation. Mouse bone marrow cell extraction was performed as previously reported (20). Briefly, bone marrow cells were ...
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell ... Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell ... Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell ... Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell ...
Physical Complications After Bone Marrow Transplantation. Survivors of hematopoietic stem cell transplantation (HSCT) in ... Secondary Malignancies After Hematopoietic Stem Cell Transplantation. *Physical Complications After Bone Marrow Transplantation ... Secondary Malignancies After Hematopoietic Stem Cell Transplantation. *Physical Complications After Bone Marrow Transplantation ... Psychosocial and Cognitive Complications of Bone Marrow Transplantation. Children receiving hematopoietic stem cell ...
Long noncoding RNAs of single hematopoietic stem and progenitor cells in healthy and dysplastic human bone marrow ... Long noncoding RNAs of single hematopoietic stem and progenitor cells in healthy and dysplastic human bone marrow ... Long noncoding RNAs of single hematopoietic stem and progenitor cells in healthy and dysplastic human bone marrow ... Long non-coding RNAs control hematopoietic stem cell function. Cell Stem Cell. 2015;16(4):426-438. ...
Bone marrow niches of germline FANCC/FANCG deficient mice enable efficient and durable engraftment of hematopoietic stem cells ... Bone marrow niches of germline FANCC/FANCG deficient mice enable efficient and durable engraftment of hematopoietic stem cells ... Bone marrow niches of germline FANCC/FANCG deficient mice enable efficient and durable engraftment of hematopoietic stem cells ... 1Comprehensive Bone Marrow Failure Center, Childrens Hospital of Philadelphia, Philadelphia. *. 2Blood and Marrow Transplant ...
Hematopoietic stem cell transplant-complications (bone marrow transplant complications; cord blood transplant complications; ... Close more info about Hematopoietic stem cell transplant-complications (bone marrow transplant complications; cord blood ... Close more info about Hematopoietic stem cell transplant-complications (bone marrow transplant complications; cord blood ... Graft source (cord blood, bone marrow or peripheral blood stem cells) which may impact on speed to marrow recovery. ...
Mesenchymal stem cells (MSCs) have been shown to support hematopoiesis in vivo and to display potent immunosuppressive effects ... Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for severe aplastic anemia (SAA) is mainly limited by the ... Cotransplantation of bone marrow-derived mesenchymal stem cells in haploidentical hematopoietic stem cell transplantation in ... Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for severe aplastic anemia (SAA) is mainly limited by the ...
Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow failure. ... Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow failure. ... Inherited bone marrow failure syndromes (IBMFSs) such as Fanconi Anemia (FA) and Shwachman-Diamond syndrome (SDS) feature ... Using deep phenotypic analysis of early progenitors in FA/SDS bone marrow samples we revealed selective survival of progenitors ...
Hematopoietic stem cell transplantation (HSCT) using an optimized conditioning regimen is essential for the long-term survival ... Recommendations on hematopoietic stem cell transplantation for inherited bone marrow failure syndromes. Bone Marrow Transplant ... Disease-specific hematopoietic stem cell transplantation in children with inherited bone marrow failure syndromes. Zeitschrift: ... Disease-specific hematopoietic stem cell transplantation in children with inherited bone marrow failure syndromes ...
RDTR/SCF-LVs might completely obviate ex vivo handling and simplify gene therapy for many hematopoietic defects because of ... A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow ... A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow ... RDTR/SCF-LVs might completely obviate ex vivo handling and simplify gene therapy for many hematopoietic defects because of ...
Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation): How CPT Codes Are Reported (June 2009) - Subscription ... Hematopoietic Cell Transplantation (Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation): How CPT Codes Are ... June 2009 pages 3-6 Hematopoietic Cell Transplantation (Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation): ... bone marrow, blood-derived peripheral stem cells, and umbilical cord blood). Special notation will be made when... ...
Identification of resident and inflammatory bone marrow derived cells in the sclera by bone marrow and haematopoietic stem cell ... Bone marrow transplantation. To investigate the participation of bone marrow cells in the sclera, we performed bone marrow ... Haematopoietic stem cell transplantation. To characterise bone marrow derived stem cells in the mouse sclera, we examined HSC ... Schematic diagram of bone marrow (BM) and haematopoietic stem cell (HSC) transplantation (A) and representative images of BM (B ...
The bone marrow, a highly vascularized fibrous tissue, is the physiological niche of hematopoietic stem cells (HSCs) in the ... A new model for the human bone marrow niche supports the culture of hematopoietic stem and progenitor cells. ... collaborated on the development of a 3D in vitro model of the human bone marrow niche, for the culture of hematopoietic stem ... A Human Hematopoietic Niche Model Supporting Hematopoietic Stem and Progenitor Cells In Vitro. Maaike V.J. Braham, Amélie S.P. ...
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2005 Jun;11; ... Pulmonary cytolytic thrombi after allogeneic hematopoietic cell transplantation: a further histologic description. ... Status post-hematopoietic stem cell (HSCT) or bone marrow transplantation (BMT) 5 ...
Lung function and airway inflammation monitoring after hematopoietic stem cell transplantation. Respiratory medicine 2013 Dec; ... Pulmonary function following allogeneic stem cell transplantation in childhood: a retrospective cohort study of 51 patients. ... Status post-hematopoietic stem cell (HSCT) or bone marrow transplantation (BMT) 5 ...
Self-Renewing Human Bone Marrow Mesenspheres Promote Hematopoietic Stem Cell Expansion. Research output: Contribution to ... Biology of Human Primary Bone Marrow Mesenchymal Stromal Stem Cells. Roshanak Ghazanfari, 2017, Lund: Lund University: Faculty ... such as bone marrow stromal stem/progenitor cells (BMSCs). Plastic-adherent BMSCs may be insufficient to preserve primitive ... Strategies for expanding hematopoietic stem cells (HSCs) include coculture with cells that recapitulate their natural ...
Although the response to this process in hematopoietic stem cells (HSCs) is crucial, the mechanisms by which hematopoietic ... Stem cells of intensely regenerative tissues are susceptible to cellular damage. ... Reactive oxygen species contribute to dysfunction of bone marrow hematopoietic stem cells in aged C57BL/6 J mice. ... Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury. Transl Cancer Res. 2013;2:397-411. ...
... cell depletion rapidly reduces HSC content in the bone marrow. Purified HSCs home near nestin(+) MSCs in the bone marrow of ... between two distinct somatic stem-cell types and are indicative of a unique niche in the bone marrow made of heterotypic stem- ... cell depletion significantly reduces bone marrow homing of haematopoietic progenitors. These results uncover an unprecedented ... Nestin(+) MSCs contain all the bone-marrow colony-forming-unit fibroblastic activity and can be propagated as non-adherent ...
  • This two (2) day program is designed for Registered Nurses and Nurse Practitioners caring for patients undergoing Hematopoietic Stem Cell Transplantation (HSCT). (mskcc.org)
  • Animation and slides providing graphic explanation of Bone Marrow Transplantation (BMT)/Stem Cell Transplantation that is done for leukemia and other blood-related disorders. (medindia.net)
  • The identification of new mechanisms that regulate the trafficking of hematopoietic stem/progenitor cells (HSPCs) cells has important implications, not only for hematopoietic transplantation but also for cell therapies in regenerative medicine for patients with acute myocardial infarction, spinal cord injury, and stroke, among others. (hindawi.com)
  • For many decades, bone marrow (BM) transplantation was the only viable method for transplanting hematopoietic stem cells, although their presence had been demonstrated in peripheral blood. (hindawi.com)
  • The successful transplantation of hematopoietic stem/progenitor cells (HSPCs) is based on their ability to home to the BM niche and on their engraftment capacity. (hindawi.com)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) is a standard therapeutic intervention for hematological malignancies and several monogenic diseases. (nature.com)
  • Barriga F, Ramírez P, Wietstruck A, Rojas N. Hematopoietic stem cell transplantation: clinical use and perspectives. (nature.com)
  • Indications for autologous and allogeneic hematopoietic cell transplantation: guidelines from the american society for blood and marrow transplantation. (nature.com)
  • Immunobiology of allogeneic hematopoietic stem cell transplantation. (nature.com)
  • Norkin M, Wingard JR. Recent advances in hematopoietic stem cell transplantation. (nature.com)
  • Risk factors for acute GVHD and survival after hematopoietic cell transplantation. (nature.com)
  • Henig I, Zuckerman T. Hematopoietic stem cell transplantation-50 years of evolution and future perspectives. (nature.com)
  • Long-term outcome of allogeneic hematopoietic stem cell transplantation in patients with juvenile metachromatic leukodystrophy compared with nontransplanted control patients. (nature.com)
  • We sought to determine whether enzyme replacement therapy (ERT) with iduronidase in the peritransplant period affects outcome of hematopoietic stem cell transplantation (HSCT) for MPS IH. (nature.com)
  • The first experience with hematopoietic stem cell transplantation (HSCT) as therapy for Hurler was reported by Hobbs, 8 and since that time HSCT has been accepted as the standard of care for patients with MPS IH, as this results in engraftment of cells within the brain, providing enzyme to the central nervous system, halting neurocognitive decline. (nature.com)
  • While outcomes after HSCT have improved with the availability of improved methods for stem cell graft typing and supportive care, concerns remain regarding the toxicity of transplantation. (nature.com)
  • Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
  • In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • These data reinforce the need for marked vigilance in ensuring proper screening and management of long-term survivors of bone marrow transplantation. (medscape.com)
  • To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
  • Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for severe aplastic anemia (SAA) is mainly limited by the high incidence of graft failure and GvHD. (ovid.com)
  • Hematopoietic stem cell transplantation (HSCT) using an optimized conditioning regimen is essential for the long-term survival of patients with inherited bone marrow failure syndromes (IBMFS). (springermedizin.de)
  • Gluckman E, Wagner JE (2008) Hematopoietic stem cell transplantation in childhood inherited bone marrow failure syndrome. (springermedizin.de)
  • Peffault de Latour R, Peters C, Gibson B et al (2015) Recommendations on hematopoietic stem cell transplantation for inherited bone marrow failure syndromes. (springermedizin.de)
  • Bizzetto R, Bonfim C, Rocha V et al (2011) Outcomes after related and unrelated umbilical cord blood transplantation for hereditary bone marrow failure syndromes other than Fanconi anemia. (springermedizin.de)
  • Kekre N, Antin JH (2014) Hematopoietic stem cell transplantation donor sources in the 21st century: choosing the ideal donor when a perfect match does not exist. (springermedizin.de)
  • June 2009 pages 3-6 Hematopoietic Cell Transplantation (Hematopoietic Stem Cell Transplantation, Bone Marrow Transplantation): How CPT Codes Are Reported This article describes the hematopoietic cell transplantation (HCT) process and identifies the appropriate CPT codes to use at each step along the way, including identifying a suitable donor, pretransplant patient conditioning, harvesting and infusing the graft, and posttransplant care. (findacode.com)
  • To characterise bone marrow derived cells in the sclera under normal and inflammatory conditions, we examined their differentiation after transplantation from two different sources, bone marrow and haematopoietic stem cells (HSC). (pubmedcentralcanada.ca)
  • Immunohistochemistry showed that GFP (+) CD11c (+), GFP (+) CD11b (+) cells migrated in the sclera after bone marrow and HSC transplantation. (pubmedcentralcanada.ca)
  • Pulmonary cytolytic thrombi after allogeneic hematopoietic cell transplantation: a further histologic description. (pneumotox.com)
  • These properties of IL-33 have clinical implications in hematopoietic stem cell transplantation. (jimmunol.org)
  • Allogeneic hematopoietic stem cell transplantation for inherited bone marrow failure syndromes. (telomerescience.com)
  • In these congenital disorders, hematopoietic stem cell transplantation (HSCT) is often a consideration. (telomerescience.com)
  • Among them, autologous transplantation of c-kit-positive cardiac stem cells in congestive heart failure patients resulted in an outstanding outcome, with long-lasting beneficial effects without major adverse events. (hindawi.com)
  • Haematopoietic stem cell transplantation (or bone marrow transplantation as it is more commonly known) is a specialised procedure, which is effective in treating many types of cancers as well as some non- malignant conditions. (parkwaycancercentre.com)
  • Haematopoietic stem cell transplantation (or bone marrow transplantation as it is commonly termed) refers to a highly specialised procedure where stem cells are transplanted into the body for treatment of cancers and blood disorders. (parkwaycancercentre.com)
  • This makes stem cell transplantation an exciting medical advancement. (parkwaycancercentre.com)
  • What conditions can benefit from stem cell transplantation? (parkwaycancercentre.com)
  • Is stem cell transplantation safe? (parkwaycancercentre.com)
  • Even though stem cell transplantation has been proven to be a life-saving treatment, there are associated risks. (parkwaycancercentre.com)
  • During hematopoietic regeneration after bone marrow (BM) transplantation, persistent activation of NRF2 reduced the BM reconstitution capacity of LT-HSCs, suggesting that NRF2 reduces the quiescence of LT-HSCs and promotes their differentiation, leading to eventual exhaustion. (elsevier.com)
  • Determine whether the incidence of neutrophil engraftment is acceptable in high-risk patients with Fanconi's anemia treated with busulfan, cyclophosphamide, fludarabine, and antithymocyte globulin followed by allogeneic hematopoietic stem cell transplantation. (clinicaltrials.gov)
  • Allogeneic hematopoietic stem cell transplantation (HSCT): Patients undergo allogeneic HSCT (using bone marrow or umbilical cord blood) on day 0. (clinicaltrials.gov)
  • Cytoreductive preparative regimen consisting of busulfan, cyclophosphamide, fludarabine phosphate, methylprednisolone, and antithymocyte globulin (ATG) followed by hematopoietic stem cell transplantation (HSCT) and post-transplant use of bone marrow-stimulating filgrastim. (clinicaltrials.gov)
  • Over the past 15 years we have been investigating an alternative approach to treating HIV-1/AIDS, based on the creation of a disease-resistant immune system through transplantation of autologous, gene-modified (HIV-1-resistant) hematopoietic stem and progenitor cells (GM-HSPC). (mdpi.com)
  • Bone marrow transplantation is performed by physicians including oncologists specialized in doing the transplantation. (medindia.net)
  • Siblings or close relatives are preferred for bone marrow transplantation. (medindia.net)
  • RATIONALE: Bone marrow and peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy used to kill cancer cells. (clinicaltrials.gov)
  • PURPOSE: Phase II trial to study the effectiveness of T-cell depleted bone marrow and G-CSF stimulated peripheral stem cell transplantation in treating patients with leukemia, lymphoblastic lymphoma, myelodysplastic syndrome, or aplastic anemia. (clinicaltrials.gov)
  • Determine the potential of T-cell-depleted bone marrow and peripheral blood stem cells (PBSC) from HLA-haplotype, partially matched related donors to induce extended disease-free survival in patients with leukemia, lymphoblastic lymphoma, myelodysplastic syndrome, or severe aplastic anemia who would otherwise be ineligible for transplantation because of the lack of an HLA-identical related or unrelated donor. (clinicaltrials.gov)
  • Correlate the doses of PBSC and clonable T-cells with the incidence of engraftment, extent of chimerism, incidence and severity of acute and chronic GVHD, characteristics of hematopoietic and immunologic reconstitution, and overall and disease-free survival rates at 2-4 years after transplantation in these patients. (clinicaltrials.gov)
  • Harvest: Beginning 6-10 days before transplantation, allogeneic bone marrow is harvested and treated in vitro. (clinicaltrials.gov)
  • Beginning 5-6 days before transplantation, filgrastim (G-CSF)-stimulated, allogeneic peripheral blood stem cells (PBSC) are harvested, selected for CD34+ cells, and treated in vitro. (clinicaltrials.gov)
  • Transplantation: CD34+, E-rosette and T-cell-depleted PBSC are infused over 15 minutes and then T-cell-depleted bone marrow is infused over 1-5 minutes on day 0. (clinicaltrials.gov)
  • Patients with graft failure are offered autologous bone marrow transplantation (BMT) or second allogeneic BMT. (clinicaltrials.gov)
  • Publications] Ueda T.: 'Massive pericardial and pleural effusion with anasarca following allogeneic bone marrow transplantation. (nii.ac.jp)
  • Publications] Ishii T.: 'Improvement in bronchiolitis obliterans organizing pneumonia by combination of oral predonisolone and low dose erythromycin in a child after allogegeneic bone marrow transplantation. (nii.ac.jp)
  • Pulmonary complications are common following hematopoietic cell transplantation (HCT) and contribute significantly to its morbidity and mortality. (frontiersin.org)
  • Over the last 20 years, haematopoietic stem cell transplantation (HSCT) has been used to treat patients with severe autoimmune and inflammatory diseases whose response to standard treatment options has been limited, resulting in a poor long-term prognosis in terms of survival or disability. (nih.gov)
  • Despite the availability of new antifungal compounds, invasive fungal infection remains a significant cause of morbidity and mortality in children and adults undergoing allogeneic hematopoietic stem cell transplantation (HSCT). (frontiersin.org)
  • In the transplantation experiments of CD34 + cells obtained from human cord blood, CD34 + CD38 - cells (hHSCs) were more increased in hJ1-NOG recipient mice than in nontransgenic littermates in mouse bone marrow environment. (elsevier.com)
  • This section describes and discusses genitourinary system (GUS) complications of bone marrow transplantation (BMT). (renalandurologynews.com)
  • Kidney complications can be acute or chronic after hematopoietic stem cell transplantation (HCT). (renalandurologynews.com)
  • The Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation is composed of 12 physicians with subspecialty oncology experience in specific hematologic malignancies and palliative care, which provides clinical expertise and research opportunities for leukemias and MDS, lymphomas, myeloma, and bone marrow transplantation related to these conditions. (jefferson.edu)
  • In an October 2014 article published in the Biology of Blood and Marrow Transplantation, Jefferson reported "disease-free and overall survival at 2 years are 74% and 77%, respectively, consistent with the findings (of previous work) and supporting the use of this approach in earlier stage patients lacking a matched related donor. (jefferson.edu)
  • Acute graft-versus-host disease (aGVHD) is the most frequent and severe complication after allogeneic hematopoietic stem cell transplantation (HSCT). (scirp.org)
  • A retrospective cohort study based on data collected from the Department of Hematopoietic Stem Cell Transplantation at the Instituto Nacional de Pediatría (INP) from January 1998 to December 2016 was performed to identify if prior infection was a predictive risk factor for aGVHD. (scirp.org)
  • This is a retrospective cohort study based on data collected from the allogenic transplant performed at the Department of Hematopoietic Stem Cell Transplantation at the Instituto Nacional de Pediatría (INP) registered in a database, from January 1998 to December 2016. (scirp.org)
  • Fuchs E. Haploidentical hematopoietic cell transplantation. (medlineplus.gov)
  • Now, treatment of a number of diseases is possible through stem cell transplantation. (medscape.com)
  • Pilot studies of autologous stem cell transplantation using peripheral blood have demonstrated rapid engraftment with this technique. (medscape.com)
  • Incidence of supraventricular arrhythmias during autologous peripheral blood stem cell transplantation. (mayoclinic.org)
  • Biology of Blood and Marrow Transplantation. (mayoclinic.org)
  • Here, we report our experience with 4 patients with relapsed AML after allogeneic hematopoietic stem cell transplantation (allo-HSCT), who were treated with the immunocytokine F16-IL2, in combination with low-dose cytarabine. (aacrjournals.org)
  • Reciprocal and Serial Bone marrow transplantation studies suggested an alteration of the niche for HSCs in Itch deficient BM. (ashpublications.org)
  • The kinetics of donor cell repopulation of the lymphoid and myeloid compartments by Ly-5.1 + donor hematopoietic stem cells (ie, competitive repopulation units [CRU]) were monitored at various time points after the transplantation by Ly-5 analysis of the peripheral white blood cells (WBC). (uthscsa.edu)
  • We performed a retrospective study to examine the preventive effects of newquinolones for endogenous infection in patients receiving various allogeneic hematopoietic stem cell transplantation including bone marrow transplantation (BMT), peripheral blood stem cell transplantation (PBSCT), and cord blood transplantation (CBT). (elsevier.com)
  • Hematopoietic stem cell transplantation (HSCT) is an established procedure for many acquired and congenital disorders of the hematopoietic system, including disorders of the immune system, and as enzyme replacement in metabolic disorders. (gaselectricity.in)
  • Origin electricity faults 1, 2, 3, 4 The annual activity survey of the European Society of Blood and Marrow Transplantation (EBMT), describing the status of HSCT in Europe and affiliated countries, has become an instrument used to observe trends and to monitor changes in technology use. (gaselectricity.in)
  • In addition, short-term osteoinductive treatment favored in vivo hematopoietic recovery in lethally irradiated mice that underwent BM transplantation. (fujita-hu.ac.jp)
  • Our findings demonstrate the unique biological characteristics of e-MSCs as hematopoiesis-regulatory stromal cells at differentiation stage between MSCs and osteoprogenitor cells and have significant implications in developing new strategy for using pharmacological osteoinductive treatment to support hematopoiesis in hematopoietic stem and progenitor cell transplantation. (fujita-hu.ac.jp)
  • Biol Blood Marrow Transplant. (nature.com)
  • Bone Marrow Transplant. (nature.com)
  • high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
  • Day post-transplant, which will impact on complications likely to occur, types of infections likely and expectation of timing for marrow recovery. (renalandurologynews.com)
  • This study examined the incidence of human herpes virus-6 (HHV-6) and human cytomegalovirus (HCMV) infections that are potentially transmitted to haematopoietic stem cells (HSC) transplant recipients via bone marrow (BM) or umbilical cord blood (UCB). (bvsalud.org)
  • At PCC Haematology and Stem Cell Transplant Centre, our transplant specialists have trained and worked in some of the notable transplant centres in the world. (parkwaycancercentre.com)
  • 4. What is bone marrow hematopoietic stem cell transplant used for? (climbforlife.it)
  • With the expression "bone marrow hematopoietic stem cell transplant" we intend a complex procedure used especially, but not only, in the treatment of leukimias and lymphomas. (climbforlife.it)
  • RATIONALE: A bone marrow or umbilical cord blood transplant may be able to replace blood-forming cells that were destroyed by chemotherapy. (clinicaltrials.gov)
  • Giving combination chemotherapy before a donor stem cell transplant may make the transplant more likely to work. (clinicaltrials.gov)
  • PURPOSE: This clinical trial is studying how well combination chemotherapy works in treating high risk patients who are undergoing a donor stem cell transplant for Fanconi's anemia. (clinicaltrials.gov)
  • A stem cell transplant from a genetically matched sibling donor can help or cure this disease in 85 to 100 percent of patients. (clinicaltrials.gov)
  • This study will test the success of a new approach to stem cell transplant for SAA. (clinicaltrials.gov)
  • Patients in this study will receive drugs and radiation treatment to destroy their diseased bone marrow and to prepare them for stem cell transplant. (clinicaltrials.gov)
  • The cost for bone marrow transplant may vary for each patient depending on the type of transplant. (medindia.net)
  • The purpose of this study is to determine the clinical benefit and characterize the safety profile of tabelecleucel for the treatment of Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV+ PTLD) in the setting of (1) solid organ transplant (SOT) after failure of rituximab and rituximab plus chemotherapy or (2) allogeneic hematopoietic cell transplant (HCT) after failure of rituximab. (clinicaltrials.gov)
  • Our Hematopoietic Stem Cell Transplant Program is the leader in volume and types of transplants, averaging over 250 transplantations per year, resulting in survival rates consistently exceeding the national survival rate. (northwestern.edu)
  • A bone marrow transplant is a procedure to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. (medlineplus.gov)
  • Autologous bone marrow transplant -- The term auto means self. (medlineplus.gov)
  • Allogeneic bone marrow transplant -- The term allo means other. (medlineplus.gov)
  • The stem cells are frozen and stored until they are needed for a transplant. (medlineplus.gov)
  • A stem cell transplant is usually done after chemotherapy and radiation is complete. (medlineplus.gov)
  • A bone marrow transplant replaces bone marrow that is either not working properly or has been destroyed (ablated) by chemotherapy or radiation. (medlineplus.gov)
  • Hematopoietic cell transplant (HCT) is increasingly used as a treatment for various malignant and non-malignant disease processes. (frontiersin.org)
  • 1 Hematopoietic Stem Cell Transplant and Cell Therapy Program, National Institute of Pediatrics (INP), Mexico City, México . (scirp.org)
  • People with life-threatening diseases, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant . (medlineplus.gov)
  • This is now often called a stem cell transplant. (medlineplus.gov)
  • Autologous bone marrow transplant is when people donate their own bone marrow. (medlineplus.gov)
  • Allogenic bone marrow transplant is when another person donates bone marrow. (medlineplus.gov)
  • But only about 30% of people who need a bone marrow transplant can find a matching donor in their own family. (medlineplus.gov)
  • Doctors can then use the registry to find a matching donor for a person who needs a bone marrow transplant. (medlineplus.gov)
  • Stem cell transplant for cancer. (medlineplus.gov)
  • The history of stem cell transplant goes back as early as 1939, when the first documented clinical transplant was performed. (medscape.com)
  • In 1968, the first successful allogenic stem cell transplant was made possible followed by series of achievements in 1970s and 1980s. (medscape.com)
  • Donor lymphocyte infusion (DLI) has a significant role in relapsed patients with chronic myelogenous leukemia (CML) after stem cell transplant. (medscape.com)
  • The success of collection of mobilized stem cells from peripheral blood was a milestone in the history of transplant. (medscape.com)
  • Mayo Clinic doctors and scientists are actively studying ways to improve bone marrow transplant outcomes. (mayoclinic.org)
  • Learn more about research in the Bone Marrow Transplant Program . (mayoclinic.org)
  • See a list of publications about bone marrow transplant by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. (mayoclinic.org)
  • Please be prepared to specify the transplant service needed (bone marrow, hand, heart, kidney, pancreas, liver or lung transplant) so that the most appropriate person can assist you. (mayoclinic.org)
  • Allogeneic blood and marrow transplant (BMT). (mayoclinic.org)
  • This process, termed mobilization, has become the primary means to acquire a stem cell graft for hematopoietic transplant at most transplant centers. (hoggattlab.com)
  • Studies here finally demonstrate that individual HSCs sorted from adult bone marrow and transferred to lethally irradiated recipients clearly give rise to B-2, MZ B, and B-1b, but does not detectably reconstitute B-1a cells. (pnas.org)
  • Adult hematopoietic stem cells (HSCs) exist in a relatively quiescent state in the bone marrow (BM) microenvironment to fulfill long-term self-renewal and multilineage differentiation functions, an event that is tightly regulated by extrinsic and intrinsic cues. (pnas.org)
  • In a conditional-knockout mouse model, we show that Cdc42 −/− HSCs enter the active cell cycle, resulting in significantly increased number and frequency of the stem/progenitor cells in the BM. (pnas.org)
  • Adult hematopoietic stem cells (HSCs) exist in a relatively quiescent state in the bone marrow (BM) microenvironment to execute long-term self-renewal and multilineage differentiation functions ( 1 - 3 ). (pnas.org)
  • Purified HSCs home near nestin(+) MSCs in the bone marrow of lethally irradiated mice, whereas in vivo nestin(+) cell depletion significantly reduces bone marrow homing of haematopoietic progenitors. (nih.gov)
  • In adult mammals, hematopoietic stem cells (HSCs) reside in the bone marrow (BM) and are maintained in a quiescent and undifferentiated state through adhesive interactions with specialized microenvironmental niches. (bloodjournal.org)
  • 10 Recently, expression of several JAM family members, such as JAM-A, JAM-C, JAM4, or ESAM, has been reported in hematopoietic stem cells (HSCs), although a function for these proteins in hematopoiesis remains unknown. (bloodjournal.org)
  • In adult mammals, HSCs are rare cells mainly located in the bone marrow (BM) and able to generate all mature blood cells. (bloodjournal.org)
  • Hematopoietic stem cells (HSCs) reside in specialized bone marrow (BM) niches regulated by the sympathetic nervous system (SNS). (nih.gov)
  • Thus, strategies that target BM MΦ hold the potential to augment stem cell yields in patients that mobilize HSCs/progenitors poorly. (nih.gov)
  • By performing a cross-sectional study in mice, we discover that hallmarks of aging in HSCs and hematopoiesis begin to accumulate by middle age and that the bone marrow (BM) microenvironment at middle age induces and is indispensable for hematopoietic aging. (mdc-berlin.de)
  • Some lncRNAs were found to be enriched in hematopoietic stem cells (HSCs) 12 or dynamically expressed during erythropoiesis. (haematologica.org)
  • Hematopoietic stem cells (HSCs) residing in the bone marrow (BM) accumulate during aging but are functionally impaired. (csic.es)
  • The bone marrow, a highly vascularized fibrous tissue, is the physiological niche of hematopoietic stem cells (HSCs) in the adult. (hubrecht.eu)
  • There, HSCs can self-renew or differentiate into hematopoietic progenitor cells (HPCs) to produce daily all mature blood cells needed throughout life. (hubrecht.eu)
  • Strategies for expanding hematopoietic stem cells (HSCs) include coculture with cells that recapitulate their natural microenvironment, such as bone marrow stromal stem/progenitor cells (BMSCs). (lu.se)
  • Expanded HSCs were serially transplantable in immunodeficient mice and significantly increased long-term human hematopoietic engraftment. (lu.se)
  • Although the response to this process in hematopoietic stem cells (HSCs) is crucial, the mechanisms by which hematopoietic homeostasis is sustained are not completely understood. (biomedcentral.com)
  • One of the common cancer treatment-related late effects is long-term bone marrow (LT-BM) injury resulting from IR- and/or chemotherapy-induced damage to hematopoietic stem cells (HSCs) ( 2 ). (amegroups.com)
  • The murine hematopoietic system consists of the rare HSCs (CD150 + CD48 - Lin - Sca1 + c-kit + or CD150 + CD48 - LSK cells), including long-term HSCs (LT-HSCs, CD34 - CD150 + CD48 - LSK cells) and short-term HSCs (ST-HSCs, CD34 + CD150 + CD48 - LSK cells), at the top of the hierarchy ( 5 , 6 ). (amegroups.com)
  • HSCs are responsible for sustaining hematopoietic homeostasis and regeneration after injury for the entire life of an organism. (amegroups.com)
  • Hematopoietic stem cells (HSCs) depend in the bone fragments marrow (BM) niche for their maintenance, proliferation, and differentiation. (researchhunt.com)
  • Along with cell-intrinsic applications, the cell can be motivated by the specific niche market destiny of HSCs, which in switch govern the homeostasis of the hematopoietic program (Nakamura-Ishizu et al. (researchhunt.com)
  • Furthermore, HSCs reside near bone-lining OBLs and older Mks, which both support HSCs buy 950769-58-1 by creating Thpo (Yoshihara et al. (researchhunt.com)
  • By transferring mouse aged hematopoietic stem cells (aged HSCs, *1) to the environment of young mice (bone marrow niche, *2), it was demonstrated that the pattern of stem cell gene expression was rejuvenated to that of young hematopoietic stem cells. (amoxicillin-buyamoxil.info)
  • On the other hand, the function of aged HSCs did not recover in the young bone marrow niche. (amoxicillin-buyamoxil.info)
  • The epigenome (DNA methylation, *3) of aged HSCs did not change significantly even in the young bone marrow niche, and DNA methylation profiles were found to be a better index than the gene expression pattern of aged HSCs. (amoxicillin-buyamoxil.info)
  • The research group investigated whether rejuvenating aged HSCs in a young bone marrow niche environment would rejuvenate. (amoxicillin-buyamoxil.info)
  • They found that engrafted aged HSCs were less capable of producing hematopoietic cells than younger HSCs. (amoxicillin-buyamoxil.info)
  • They also showed that differentiation of aged HSCs into multipotent progenitor cells was persistently impaired even in the young bone marrow niche, and that the direction of differentiation was biased. (amoxicillin-buyamoxil.info)
  • It was found that the transfer of aged HSCs to the young bone marrow niche does not improve their stem cell function. (amoxicillin-buyamoxil.info)
  • Aging studies focusing on HSCs have been actively pursued in mice using a bone marrow transfer model. (amoxicillin-buyamoxil.info)
  • To clarify the role of the KEAP1-NRF2 system in tissue stem cells, we focused on hematopoiesis in this study and used Keap1-deficient mice to examine the effects of persistent activation of NRF2 on long-term hematopoietic stem cells (LT-HSCs). (elsevier.com)
  • In this study we demonstrate that whenever a fraction of mouse or human adult bone marrow-derived stem cells (lineage-negative hematopoietic stem cells [Lin- HSCs]) containing endothelial precursors stabilizes and rescues retinal blood vessels that would ordinarily completely degenerate, a dramatic neurotrophic rescue effect is also observed. (jci.org)
  • The vast majority of hematopoietic stem cells (HSCs) reside in specialized niches within the bone marrow during steady state, maintaining lifelong blood cell production. (biomedcentral.com)
  • 10 ) succeeded in exploiting hematopoietic stem cells (HSCs) to treat new-onset T1D and achieved encouraging results, paving the way for another three trials, which were initiated worldwide ( 11 , 12 ). (diabetesjournals.org)
  • Selective activation of p38 was also observed in bone marrow hematopoietic stem cells (HSCs) after mice were exposed to a sublethal total-body dose (6.5 Gy) of radiation. (nih.gov)
  • Treatment of the irradiated mice with SB after total-body irradiation (TBI) increased the frequencies of HSCs and hematopoietic progenitor cells (HPCs) in their bone marrow and the clonogenic functions of the irradiated HSCs and HPCs. (nih.gov)
  • Hematopoietic stem cells- (HSCs-) based therapy requires ex vivo expansion of HSCs prior to therapeutic use. (hindawi.com)
  • In this study, the role of Hibiscus sabdariffa L. (Roselle) in maintenance of cultured murine bone marrow-derived HSCs was investigated. (hindawi.com)
  • Hematopoietic stem cells (HSCs) offer valuable source for cell-based therapy and regenerative medicine because of their self-renewing and multipotency capacity [ 1 ]. (hindawi.com)
  • However, the unique characteristics of HSCs are often altered once they leave the bone marrow niche, limiting the ex vivo expansion of HSCs. (hindawi.com)
  • Hematopoietic stem cells (HSCs) located in the bone marrow supply us with tens of billions of new blood cells every day through cell division. (u-tokyo.ac.jp)
  • These dormant HSCs are thought to exist in a microenvironment termed the bone marrow niche. (u-tokyo.ac.jp)
  • The research group determined that glial cells suppress HSC division by activating the protein TGF-β, and that HSCs in the bone marrow niche are affected by TGF-β through contact with glial cells. (u-tokyo.ac.jp)
  • The mobilizing effect of granulocyte colony-stimulating factor is not completely understood, but recent studies suggest that its capacity to mobilize HSCs, at least in part, is a consequence of alterations to the hematopoietic niche. (hoggattlab.com)
  • HSCs reside in specialized niches in bone marrow (BM), which beyond physical support are essential to regulate their function. (bio.mx)
  • In 2014 he as awarded a Kay Kendall Leukaemia Fund Fellowship to investigate the bone marrow niche of platelet-biased HSCs. (bio.mx)
  • Here we show that, in a hematopoietic stem cell (HSC) -specific inducible knockout model, the cytoskeleton-modulating protein profilin 1 (pfn1) is essential for the maintenance of multiple cell fates and metabolism of HSCs. (ashpublications.org)
  • The deletion of pfn1 in HSCs led to bone marrow failure, loss of quiescence, increased apoptosis, and mobilization of HSCs in vivo . (ashpublications.org)
  • Thus, pfn1 plays an essential role in regulating the retention and metabolism of HSCs in the bone marrow microenvironment. (ashpublications.org)
  • Hematopoietic stem cells (HSCs) reside in a complex cellular microenvironment within the bone marrow. (ashpublications.org)
  • Mobilization of hematopoietic stem cells (HSCs) from the bone marrow (BM) into blood circulation can be elicited by the cytokine granulocyte-colony stimulating factor (GCSF). (yu.edu)
  • Microarray analysis of Chrm1-/- HSCs indicated that glucocorticoids contribute to the steady state organization of 3D actin structures and indeed, hematopoietic cells isolated from Chrm1-/- and Nr3c1Delta/Delta mice were observed to exhibit reduced polymerized actin by phalloidin staining compared to wild-type cells. (yu.edu)
  • Ablation of conventional DCs (cDCs) results in hematopoietic stem/progenitor cell (HSPC) mobilization that was greater than that seen with ablation of bone marrow macrophages, and cDC ablation also synergizes with granulocyte-colony stimulating factor to mobilize HSPCs. (jci.org)
  • Loss of ASXL1 in the bone marrow niche dysregulates hematopoietic stem and progenitor cell fates. (sigmaaldrich.com)
  • Furthermore, Asxl1 deletion in the mouse BMSCs altered hematopoietic stem and progenitor cell (HSC/HPC) pool and a preferential myeloid lineage increment. (sigmaaldrich.com)
  • Cooperation of beta(2)- and beta(3)-adrenergic receptors in hematopoietic progenitor cell mobilization. (semanticscholar.org)
  • Concomitantly, IL-33 induced hematopoietic stem and progenitor cell (HSPC) mobilization and extramedullary hematopoiesis. (jimmunol.org)
  • Conditional Sirt1 deletion in the hematopoietic stem and progenitor system promotes hematopoietic stem and progenitor cell (HSPC) expansion under stress conditions. (spandidos-publications.com)
  • Interestingly, Itch -/- recipients exhibited a five-fold increase in their donor (wild-type) hematopoietic stem and progenitor cell compartment. (ashpublications.org)
  • One hypothesis is that the intrinsic and extrinsic cues, such as bone morphogenic proteins, Ca 2+ , Notch ligands, and/or Ang-1/Tie2 ( 7 - 10 ), in the BM microenvironment may coordinately regulate the HSC quiescent state. (pnas.org)
  • However, the cell-cell interactions provided by the feeder cells in 2D co-cultures does not fully mimic the natural and complex 3D microenvironment of the bone marrow. (hubrecht.eu)
  • We define a role for a matrix glycoprotein, osteopontin (OPN), as a constraining factor on hematopoietic stem cells within the bone marrow microenvironment. (rupress.org)
  • The OPN-null microenvironment was sufficient to increase the number of stem cells associated with increased stromal Jagged1 and Angiopoietin-1 expression and reduced primitive hematopoietic cell apoptosis. (rupress.org)
  • The activation of the stem cell microenvironment with parathyroid hormone induced a superphysiologic increase in stem cells in the absence of OPN. (rupress.org)
  • The stem cell niche is a specialized microenvironment that houses and regulates the stem cell pool. (rupress.org)
  • He characterized the first hematopoietic progenitors that migrate and colonize the fetal thymus, where they encounter a specific microenvironment eliciting further differentiation through the T-lymphocyte lineage. (bio.mx)
  • How stem cells interact with the microenvironment to regulate their cell fates and metabolism is largely unknown. (ashpublications.org)
  • They also reveal a new role of NPY as a regulator of the bone marrow microenvironment and highlight the potential therapeutic value of this neuropeptide. (cshl.edu)
  • Bone marrow (BM) microenvironment has a crucial role in supporting hematopoiesis. (fujita-hu.ac.jp)
  • Myelodysplastic syndromes are a group of cancers in which immature blood cells in the bone marrow do not mature or become healthy blood cells. (northwestern.edu)
  • Stem cells are immature cells in the bone marrow that give rise to all of your different blood cells. (medlineplus.gov)
  • In line with a site-directed delivery of the cytokine, F16-IL2 led to an extensive infiltration of immune effector cells in the bone marrow. (aacrjournals.org)
  • abstract = "Tissue stem cells are maintained in quiescence under physiological conditions but proliferate and differentiate to replenish mature cells under stressed conditions. (elsevier.com)
  • A resident population of dendritic cells (DCs) has been identified in murine bone marrow, but its contribution to the regulation of hematopoiesis and establishment of the stem cell niche is largely unknown. (jci.org)
  • A niche is a subgroup of tissue cells and extracellular substrates that can indefinitely harbor one or more stem cells and control their self-renewal and progeny in vivo [ 3 ]. (hindawi.com)
  • The BM niche is strategically placed and organized to support the continuous and balanced production of hematopoietic cells through the strict control of cell survival, self-renewal, and differentiation [ 4 ]. (hindawi.com)
  • Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. (nih.gov)
  • The cellular constituents forming the haematopoietic stem cell (HSC) niche in the bone marrow are unclear, with studies implicating osteoblasts, endothelial and perivascular cells. (nih.gov)
  • Here we demonstrate that mesenchymal stem cells (MSCs), identified using nestin expression, constitute an essential HSC niche component. (nih.gov)
  • These results uncover an unprecedented partnership between two distinct somatic stem-cell types and are indicative of a unique niche in the bone marrow made of heterotypic stem-cell pairs. (nih.gov)
  • Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. (nih.gov)
  • Premature aging in Hutchinson-Gilford progeria syndrome recapitulates physiological aging features, but whether these arise from altered stem or niche cells is unknown. (csic.es)
  • A team of researchers of the UMC Utrecht (departments of Orthopaedics and Haematology) and Catherine Robin , group leader at the Hubrecht Institute (KNAW), collaborated on the development of a 3D in vitro model of the human bone marrow niche, for the culture of hematopoietic stem and progenitor cells. (hubrecht.eu)
  • The right balance between quiescence, self-renewal and differentiation is highly regulated by a close contact to cellular components (i.e. vascular endothelial cells, multipotent mesenchymal stromal cells) and non-cellular components (i.e. extracellular matrix, growth factors) of the bone marrow niche. (hubrecht.eu)
  • In vitro models of the hematopoietic system aim to support stemness and/or differentiation of hematopoietic stem and progenitor cells (HSPCs), by mimicking essential components of the bone marrow niche. (hubrecht.eu)
  • A Human Hematopoietic Niche Model Supporting Hematopoietic Stem and Progenitor Cells In Vitro. (hubrecht.eu)
  • Detection of functional haematopoietic stem cell niche using real-time imaging. (semanticscholar.org)
  • Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche. (semanticscholar.org)
  • In the present study, Sirt1 deletion in the BM niche demonstrated that the production of mature blood cells, lineage distribution within hematopoietic organs and frequencies of HSPC populations were comparable to those of controls. (spandidos-publications.com)
  • Skeletogenesis and the Hematopoietic Niche, Advances in Hematopoietic Stem Cell Research Rosana Pelayo, IntechOpen, DOI: 10.5772/32495. (intechopen.com)
  • Stem cells reside in a specialized niche that regulates their abundance and fate. (rupress.org)
  • Therefore, OPN is a negative regulatory element of the stem cell niche that limits the size of the stem cell pool and may provide a mechanism for restricting excess stem cell expansion under conditions of niche stimulation. (rupress.org)
  • In lower organisms, the niche incorporates elements that support a primitive or stem cell phenotype, as well as components that enforce terminal differentiation and end cell cycling among stem cell progeny. (rupress.org)
  • In this way, the Drosophila melanogaster germ cell niche both nurtures and constrains stem cells, maintaining strict control on stem cell number ( 1 , 2 ). (rupress.org)
  • In the murine hematopoietic stem cell niche, we and Zhang et al. (rupress.org)
  • We reasoned that the potential for OPN to affect stem cell function in the niche was great given its abundance in the proper geographic location, its receptor expression on stem cells, and the evidence for it affecting processes in other cells that might be relevant for stem cell physiology. (rupress.org)
  • Formation of the hematopoietic stem cell (HSC) niche in bone marrow (BM) is tightly associated with endochondral ossification, but little is known about the mechanisms involved. (ox.ac.uk)
  • Professor Hiromitsu Nakauchi and his research group at the Institute of Medical Science have demonstrated for the first time that the bone marrow niche includes nonmyelinating Schwann cells, a type of glial nerve cell, and have described the mechanism by which hibernation is maintained. (u-tokyo.ac.jp)
  • In recent years, it has been pointed out that even leukemia stem cells exist in a state of hibernation in the bone marrow niche. (u-tokyo.ac.jp)
  • Abrogation of IL-1 signaling specifically in LepR+ niche cells but not in hematopoietic cells impaired the platelet-biased HSC response to platelet depletion. (bio.mx)
  • Bone marrow mesenchymal stromal/stem cells (BM-MSCs) have emerged as an important cellular component of this hematopoietic stem cell niche. (ashpublications.org)
  • Mesenchymal stem cells (MSCs) have been shown to support hematopoiesis in vivo and to display potent immunosuppressive effects to prevent or treat GvHD after HSCT. (ovid.com)
  • Gas mask bong nfl Unrelated donor transplants include HSCT from unrelated donors with peripheral blood and marrow as a stem cell source but not cord blood HSCT, these are shown as cord blood HSCT in Figure 3a. (gaselectricity.in)
  • lncRNAs in hematopoietic cells closely correlated with protein-coding genes of known functions in the regulation of hematopoiesis and cell fate decisions, and the potential regulatory roles of lncRNAs in hematopoiesis were imputed by projection from protein-coding genes with a "guilt-by-association" approach. (haematologica.org)
  • Overall, the 3D model will be useful to study the role of bone marrow niches in normal hematopoiesis as well as in the case of bone marrow related diseases. (hubrecht.eu)
  • Paradoxically, MDS comes to dominate the bone marrow at the expense of residual normal hematopoiesis and thereby causes disease. (springer.com)
  • Eltrombopag (EP), a small-molecule thrombopoietin receptor (TPO-R) agonist and potent intracellular iron chelator, has shown remarkable efficacy in stimulating sustained multilineage hematopoiesis in patients with bone marrow failure syndromes, suggesting an effect at the most immature hematopoietic stem and multipotent progenitor level. (sciencemag.org)
  • Both mice lack definitive hematopoiesis and die in utero, and embryonic stem cells from these null mice are unable to contribute to definitive hematopoiesis in chimeric mice. (bloodjournal.org)
  • Inherited bone marrow failure (IBMF) syndromes are a heterogeneous group of rare hematological disorders characterized by the impairment of hematopoiesis, which harbor specific clinical presentations and pathogenic mechanisms. (telomerescience.com)
  • In Genetic Modification of Hematopoietic Stem Cells: Methods and Protocols , leading scientists in the field provide a compendium of protocols which cover the subject comprehensively, from the purification and culture of various types of hematopoietic cells for subsequent genetic modification by vector development and technical issues of small and large scale vector production, to the complex issue of monitoring and biosafety studies related to gene-modified hematopoiesis. (springer.com)
  • BM cells showed increased phosphorylation of Akt and mTorc1, and extramedullary hematopoiesis was significantly reduced by treating mice with rapamycin in vivo, suggesting that the mTorc1 pathway was activated by loss of Flcn expression in hematopoietic cells in vivo. (kumamoto-u.ac.jp)
  • Here, by using a microarray analysis, we demonstrate that human BM mesenchymal stromal/stem cells (MSCs) in an early osteoinductive stage (e-MSCs) are characterized by unique hematopoiesis-associated gene expression with an enhanced hematopoiesis-supportive ability. (fujita-hu.ac.jp)
  • Shown are the number of cDCs in the bone marrow, blood, and spleen ( n = 5, 4, 4 and 6 mice per time point). (jci.org)
  • Error bars indicate s.e.m. i , j , Immunostaining for CD150 (red), CD48 and haematopoietic lineages (blue) in femoral sections of Nes-Gfp mice. (nih.gov)
  • We have reported that global loss of Asxl1 leads to the development of myeloid malignancies and impairs bone marrow stromal cell (BMSC) fates in mice. (sigmaaldrich.com)
  • Bone marrow and HSC from green fluorescent protein (GFP) transgenic mice were transplanted into irradiated wild‐type mice. (pubmedcentralcanada.ca)
  • To investigate bone marrow derived cell recruitment under inflammatory conditions, experimental autoimmune uveitis (EAU) was induced in transplanted mice. (pubmedcentralcanada.ca)
  • Bone marrow obtained from C57BL/6 mice was transfected with a retrovirus containing EAR-2-IRES-GFP. (springer.com)
  • A ) Representative flow plots showing the gating strategy used to identify bone marrow monocytes, macrophages, and DCs using Cx3cr1CX gfp/+ mice. (jci.org)
  • H ) Bone marrow DCs were sorted from Cx3cr1 gfp/+ mice as Gr-1 - B220 - MHC-II hi CD11c hi CX3CR1-GFP hi cells. (jci.org)
  • Tens of thousands of aged hematopoietic stem/progenitor cells collected from 20-month-old mice were transplanted into 8-week-old young mice without pretreatment such as irradiation. (amoxicillin-buyamoxil.info)
  • Using studies that combine OPN-deficient mice and exogenous OPN, we demonstrate that OPN modifies primitive hematopoietic cell number and function in a stem cell-nonautonomous manner. (rupress.org)
  • We demonstrated a significant ex vivo expansion of cord blood hematopoietic stem cells capable of repopulating in NOD/SCID mice, using a combination of stem cell factor (SCF), Flk2/Flt3 ligand (FL), thrombopoietin (TPO) and a complex of interleukin (IL)-6 and soluble IL-6 receptor (IL-6/sIL-6R). (nii.ac.jp)
  • Publications] Ueda T.: 'Hematopoietic repopulation ability of cord blood CD34^+ cells in NOD/Shi-scid mice. (nii.ac.jp)
  • The human immune system can be reconstituted in experimental animals by transplanting human hematopoietic stem cells (hHSCs) into immunodeficient mice. (elsevier.com)
  • To prepare the relatively human bone marrow environment in mice, we generated nonobese diabetic/severe combined immunodeficiency/interleukin-2 receptor gamma chain null (NOG) mice expressing human Jagged1 (hJ1) in an osteoblast-specific manner (hJ1-NOG mice) to examine whether Notch signaling induced by hJ1 mediates hHSC proliferation and/or maintenance in mice. (elsevier.com)
  • The established hJ1-NOG mice possess relatively larger bone marrow space and thinner cortical bone compared with nontransgenic littermates, but the number of c-kit + Sca-1 + lineage - cells was not significantly different between hJ1-NOG and nontransgenic littermates. (elsevier.com)
  • These results suggest that hJ1-NOG mice could contribute to the growth of transplanted human CD34 + cells in a human-specific manner and be useful to study the invivo behavior and/or development of human stem cells, including cancer stem cells and immune cells. (elsevier.com)
  • HSPCs from adult mice deficient in Galpha(s) (Galpha(s)(-/-)) differentiate and undergo chemotaxis, but also do not home to or engraft in the bone marrow in adult mice and demonstrate a marked inability to engage the marrow microvasculature. (scaddenlab.com)
  • HSC that lack Flcn fail to reconstitute the hematopoietic compartment in recipient mice, demonstrating a cell-autonomous requirement for Flcn in HSC maintenance. (kumamoto-u.ac.jp)
  • [email protected]#The MEC from lung tissue of C57BL/6 mice and the HSC from bone marrow of GFP mice were used for non-contact co-culture, 2 D contact co-culture, at same time the single MEC and single HSC culture were seted up and were used as control group. (bvsalud.org)
  • Lansdorp, Peter M. / The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their adult bone marrow counterparts . (uthscsa.edu)
  • Here we show that NPY-deficient mice have significantly reduced hematopoietic stem cell (HSC) numbers and impaired regeneration in bone marrow due to apoptotic destruction of SNS fibers and/or endothelial cells. (cshl.edu)
  • Furthermore, pharmacological elevation of NPY prevented bone marrow impairments in a mouse model of chemotherapy-induced SNS injury, while NPY injection into conditional knockout mice lacking the Y1 receptor in macrophages did not relieve bone marrow dysfunction. (cshl.edu)
  • Mice harboring a glucocorticoid receptor (Nr3c1) deficient hematopoietic system also exhibited reductions in HSC mobilization, further confirming a role for glucocorticoid signals in G-CSF-elicited HSC mobilization. (yu.edu)
  • Administration of physiological levels of glucocorticoids to Chrm1-/- mice was sufficient to restore polymerization of actin in steady state hematopoietic cells. (yu.edu)
  • To further define the role of Cdc42 in HSC regulation, in this study, we present a conditional-knockout mouse model in which the cdc42 gene is inducibly deleted in hematopoietic cells. (pnas.org)
  • We characterized lncRNAs preferentially expressed in hematopoietic stem cells and in various downstream differentiated lineage progenitors. (haematologica.org)
  • Using deep phenotypic analysis of early progenitors in FA/SDS bone marrow samples we revealed selective survival of progenitors that phenotypically resembled granulocyte-monocyte progenitors (GMP). (jci.org)
  • Expression of AML1-ETO inhibited colony formation by committed progenitors, but enhanced the growth of stem cells (cobblestone area-forming cells), resulting in a profound survival advantage of transduced over nontransduced cells. (bloodjournal.org)
  • Publications] Ebihara Y: 'Exclusive expression of G-CSF receptor on myeloid progenitors in bone marrow CD34^+ cells. (nii.ac.jp)
  • Previously, in a gain-of-Cdc42 activity, Cdc42GAP −/− mouse model, we have found that constitutively increased Cdc42-GTP species cause increased hematopoietic progenitor apoptosis, disorganized actin structure, and defective engraftment without affecting the cell cycle status ( 13 ). (pnas.org)
  • Three out of 44 patients, who died early before hematopoietic engraftment, were not assessed. (ovid.com)
  • Determine the impact of filgrastim (G-CSF)-stimulated, CD34+, E-rosette and T-cell-depleted PBSC derived from an HLA-haplotype, partially matched donor on the incidence and quality of engraftment, kinetics, and quality of hematopoietic and immunologic reconstitution, and incidence and severity of graft-versus-host disease (GVHD) in these patients. (clinicaltrials.gov)
  • Haematopoietic stem and progenitor cells (HSPCs) change location during development and circulate in mammals throughout life, moving into and out of the bloodstream to engage bone marrow niches in sequential steps of homing, engraftment and retention. (scaddenlab.com)
  • If deleted after engraftment, Galpha(s) deficiency did not lead to lack of retention in the marrow, rather cytokine-induced mobilization into the blood was impaired. (scaddenlab.com)
  • and (2) allogeneic (patient receives healthy donor bone marrow, peripheral blood stem cells or umbilical cord/placental blood to restore normal marrow/immune function where it is deficient, allow otherwise potentially lethal intensive anti-cancer treatment, and provide alloreactivity that may eliminate minimal residual malignant disease). (renalandurologynews.com)
  • The information in this article is generally applicable to all three types of HCT (autologous, allogeneic related, and allogeneic unrelated) and all three graft sources (bone marrow, blood-derived peripheral stem cells, and umbilical cord blood). (findacode.com)
  • Incidence of human herpes virus-6 and human cytomegalovirus infections in donated bone marrow and umbilical cord blood hematopoietic stem cells. (bvsalud.org)
  • Stem cells are removed from a newborn baby's umbilical cord right after birth. (medlineplus.gov)
  • They have extensive experience in bone marrow transplants in both adult and paediatric patients. (parkwaycancercentre.com)
  • Our aim is to change the way in which bone marrow/hematopoietic stem cell transplants are performed and improve their efficacy. (hemogenyx-ir.com)
  • Since its inception, Jefferson's BMT Program has completed more than 1,000 bone marrow transplants, with increasingly impressive outcomes. (jefferson.edu)
  • Bone marrow transplants work best if the HLAs from the donor and the patient are a close match. (medlineplus.gov)
  • Bone marrow is the traditional source of stem cells for both autologous and homologous transplants. (medscape.com)
  • Regulation of hematopoietic stem cell release, migration, and homing from the bone marrow (BM) and of the mobilization pathway involves a complex interaction among adhesion molecules, cytokines, proteolytic enzymes, stromal cells, and hematopoietic cells. (hindawi.com)
  • Knowing the repertoire of cell signaling receptors would provide pivotal insight into the developmental and regenerative capabilities of bone marrow cell (BMC)-derived hematopoietic stem/progenitor cells (HSPCs) and bone marrow mesenchymal stromal cells (BMMSCs). (biomedcentral.com)
  • So far skeletal myoblasts, bone marrow-derived cells, mesenchymal stromal cells, and resident cardiac cells have been applied for therapeutic myocardial regeneration. (hindawi.com)
  • and (d) the effects of this mobilization on BM-derived stem/progenitor cells in clinical trials of patients with different diseases. (hindawi.com)
  • Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell. (scaddenlab.com)
  • The hematopoietic stem cell (HSC) derived from adult bone marrow (BM) is commonly thought to have multilineage potential, meaning that the HSC is considered capable of reconstituting all lymphoid, myeloid, and erythroid lineages of the immune system ( 1 , 2 ). (pnas.org)
  • Inherited bone marrow failure syndromes (IBMFSs) such as Fanconi Anemia (FA) and Shwachman-Diamond syndrome (SDS) feature progressive cytopenia and a risk of acute myeloid leukemia (AML). (jci.org)
  • IL-33 markedly promoted myelopoiesis in the bone marrow and myeloid cell emigration. (jimmunol.org)
  • Thus, AML1-ETO enhances the self-renewal of pluripotent stem cells, the physiological target of many acute myeloid leukemias. (bloodjournal.org)
  • Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease. (scaddenlab.com)
  • e-MSCs supported an enhanced expansion of CD34 + hematopoietic stem and progenitor cells, and generation of myeloid lineage cells in vitro. (fujita-hu.ac.jp)
  • Psatha N, Karponi G, Yannaki E. Optimizing autologous cell grafts to improve stem cell gene therapy. (nature.com)
  • If feasible, autologous bone marrow is harvested in the event of allogeneic graft failure. (clinicaltrials.gov)
  • However, the mechanisms underlying radiation-induced hematopoietic cell senescence are not known and thus were investigated in the present study. (nih.gov)
  • Using a well-established long-term bone marrow cell culture system, we found that radiation induced hematopoietic cell senescence at least in part via activation of p38 mitogen-activated protein kinase (p38). (nih.gov)
  • These findings suggest that activation of p38 plays a role in mediating radiation-induced hematopoietic cell senescence and residual bone marrow suppression. (nih.gov)
  • Whereas parathormone administration doubles the number of bone marrow nestin(+) cells and favours their osteoblastic differentiation, in vivo nestin(+) cell depletion rapidly reduces HSC content in the bone marrow. (nih.gov)
  • 13 , 14 RNA interference studies have revealed that lncRNAs control HSC self-renewal and differentiation, 12 erythroid precursor maturation, 14 and granulocytic differentiation of hematopoietic stem and progenitor cells (HSPCs). (haematologica.org)
  • Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation. (semanticscholar.org)
  • We demonstrate that besides their unique immunophenotype and functional differences, BMC-derived HSPCs and BMMSCs have different molecular receptor signaling transcript profiles linked to cell survival, growth, cell differentiation status, growth factor/cytokine production and genes involved in cell migration/trafficking/adhesion that may be critical to maintain their pluripotency, plasticity, and stem cell function. (biomedcentral.com)
  • Adult stem cells are rare cell populations within specific tissues defined by their ability to undergo both self-renewal and differentiation. (biomedcentral.com)
  • The self-renewal and differentiation of stem cells is probably subject to external modulation through receptors for a wide range of mediators including growth factors, cytokines, and chemokines. (biomedcentral.com)
  • Furthermore, the potential diverse developmental plasticity of both HSPCs and BMMSCs to repair-replace damaged tissue suggests that local environmental factors and extrinsic influences drive stem cell differentiation and determine the function fate of these cells. (biomedcentral.com)
  • Posttranslational modification of proteins through ubiquitylation has been proven an integrative component in the regulation of quiescence, proliferation, self-renewal and differentiation of stem cells. (ashpublications.org)
  • However, further studies revealed that Itch deficiency leads to reduced differentiation of MSCs into osteoblasts, both in-vivo and in-vitro , and therefore resulting in osteopenic bone phenotype. (ashpublications.org)
  • ESCs have the characteristic properties of a stem cell: self-renewal and differentiation. (wikipedia.org)
  • Role of insulin-like growth factors in endothelium differentiation ECs derived from stem cells are the beginning of vasculogenesis. (wikipedia.org)
  • Bone marrow DC ablation synergizes with G-CSF to mobilize HSPCs. (jci.org)
  • Our engineered primary 3D bone marrow model provides an easy and reliable model to further investigate the interactions between HSPCs and their surrounding niches (i.e. endosteal and perivascular niches). (hubrecht.eu)
  • Murine HSPCs were enriched from fluorescence-activated cell sorting (FACS)-sorted Lin - c-Kit + Sca-1 + BMCs isolated from the tibia and femoral marrow compartments. (biomedcentral.com)
  • Hematopoietic stem/progenitor cells (HSPCs) are functionally defined by their ability to self-renew and to contribute to all mature blood cell lineages [ 3 ]. (biomedcentral.com)
  • IL-33-mobilized HSPCs were capable of homing to, and of long-term reconstitution in, the bone marrow of irradiated recipients. (jimmunol.org)
  • The immune response to Staphylococcus aureus infection in skin involves the recruitment of polymorphonuclear neutrophils (PMNs) from the bone marrow via the circulation and local granulopoiesis from hematopoietic stem and progenitor cells (HSPCs) that also traffic to infected skin wounds. (jimmunol.org)
  • Conditional inactivation of Flcn in adult hematopoietic stem/progenitor cells (HSPCs) drives hematopoietic stem cells (HSC) into proliferative exhaustion resulting in the rapid depletion of HSPC, loss of all hematopoietic cell lineages, acute bone marrow (BM) failure, and mortality after 40 days. (kumamoto-u.ac.jp)
  • Tfe3 overexpression in HSPCs impaired long-term hematopoietic reconstitution in vivo, recapitulating the Flcn KO phenotype, and supporting the notion that abnormal activation of Tfe3 contributes to the Flcn KO phenotype. (kumamoto-u.ac.jp)
  • Cryopreservation of hematopoietic stem/progenitor cells (HSPCs) is associated with oxidative stress-mediatedcryodamage, hence compromising the therapeutic potency. (who.int)
  • The lncRNA transcriptome in human hematopoietic stem and progenitor cells is not comprehensively defined. (haematologica.org)
  • Our study provides a global view of lncRNAs in human hematopoietic stem and progenitor cells. (haematologica.org)
  • Retroviral gene transfer was used to examine the effect of AML1-ETO on the in vitro behavior of human hematopoietic stem and progenitor cells. (bloodjournal.org)
  • Collectively, these data suggest that bone marrow DCs play an important role in regulating HSPC trafficking, in part, through regulation of sinusoidal CXCR2 signaling and vascular permeability. (jci.org)
  • Optimal HSPC support was obtained in presence of fat cells and bone cells, together with endothelial cells. (hubrecht.eu)
  • In addition, SIRT1 activators modulate the capacity and HSPC numbers in the bone marrow (BM). (spandidos-publications.com)
  • Here, we show that murine bone marrow DCs are perivascular and have a type 2 conventional DC (cDC2) immunophenotype. (jci.org)
  • Aqueous extract of Roselle was added at varying concentrations (0-1000 ng/mL) for 24 hours to the freshly isolated murine bone marrow cells (BMCs) cultures. (hindawi.com)
  • FLCN is an essential protein required for murine embryonic development, embryonic stem cell (ESC) commitment, and Drosophila germline stem cell maintenance, suggesting that Flcn may be required for adult stem cell homeostasis. (kumamoto-u.ac.jp)
  • In some experiments cells were cultured in vitro, in other experiments cells were injected into lethally irradiated recipients, along with non-transduced bone marrow cells. (springer.com)
  • The CD45+ cells in the recipients engrafted with the cells cultured with SCF+FL+TPO+IL-6/sIL-6R consisted of various lineages and a large number of CD34+ cells, which formed human hematopoietic colonies in in vitro clonal culture. (nii.ac.jp)
  • Moreover, oxidative stress has been reported as one of the factors that promotes the premature senescence of in vitro cultured bone marrow-derived hematopoietic stem cells [ 9 ]. (hindawi.com)
  • [email protected]#To investigate the effect of microvascular endothelial cells (MEC) on the proliferation of hematopoictic stem cells (HSC) under different culture conditions in vitro. (bvsalud.org)
  • Graft source (cord blood, bone marrow or peripheral blood stem cells) which may impact on speed to marrow recovery. (renalandurologynews.com)
  • The graft source was peripheral blood stem cells ( n = 19) or cord blood stem cells ( n = 5). (springermedizin.de)
  • The patients will receive large doses of the filtered stem cells (stem cell graft). (clinicaltrials.gov)
  • 40/41) achieved hematopoietic reconstitution and sustained full donor chimerism. (ovid.com)
  • In comparion of the reconstitution between fresh CD34+ cells from 12 samples and their progenies cultured with SCF+FL+TPO+IL-6/sIL-6R, the proportion of CD45+ cells in recipient marrow was 10 times higher in the latter, indicating the significant expansion of the long-term repopulating hematopoietic stem cells. (nii.ac.jp)
  • In reconstitution analyses, pfn1 -deficient cells were selectively lost from mixed bone marrow chimeras. (ashpublications.org)
  • Additionally, bone marrow and virtually all postnatal tissues contain small numbers of self-renewal multipotent adherent stromal-mesenchymal stem cells (MSCs) that have the potential to give rise to cells of diverse cell lineages, play a pivotal role in tissue repair-regeneration and have demonstrated nonimmunogenicity and potent immunomodulatory effects [ 8 - 10 ]. (biomedcentral.com)
  • We showed that HF is associated with a profound and general BM dysfunction, simultaneously affecting multiple hematopoietic lineages. (springer.com)
  • Unique and cutting-edge, Genetic Modification of Hematopoietic Stem Cells: Methods and Protocols is an ideal, thorough resource to promote further research and the implementation of investigator-driven clinical studies using gene-modified hematopoietic cells. (springer.com)
  • Patients with an acute leukemia often present with signs and symptoms of bone marrow failure, such as fatigue and pallor, fever, infection and/or bleeding with purpura and petechiae. (medindia.net)
  • Exposure to a moderate or high total-body dose of radiation induces not only acute bone marrow suppression but also residual (or long-term) bone marrow injury. (nih.gov)
  • In the body, tissue homeostasis is established and maintained by resident tissue-specific adult stem cells (aSCs). (biomedcentral.com)
  • Varying, limiting numbers of unseparated or purified cells (Ly-5.1), either from 14.5-day-old fetal liver (FL) or from adult bone marrow (BM) were coinjected with 10 5 unseparated BM cells (Ly-5.2) into lethally irradiated adult C57B1/6 recipients (Ly-5.2). (uthscsa.edu)
  • 008) as compared with mica that had received marrow cells from primary recipients of similar numbers of adult BM CRU. (uthscsa.edu)
  • Myelodysplastic syndromes are a group of bone marrow stem cell disorders marked by ineffective blood cell production and low counts in the peripheral blood. (medindia.net)
  • Chung NG, Kim M (2014) Current insights into inherited bone marrow failure syndromes. (springermedizin.de)
  • Alter BP (2007) Diagnosis, genetics, and management of inherited bone marrow failure syndromes. (springermedizin.de)
  • Tsangaris E, Klaassen R, Fernandez CV et al (2011) Genetic analysis of inherited bone marrow failure syndromes from one prospective, comprehensive and population-based cohort and identification of novel mutations. (springermedizin.de)
  • Chronic thrombocytopenia can be associated with a variety of conditions, such as bone narrow failure syndromes and immune disorders. (sciencemag.org)
  • We treat a number of blood and bone marrow disorders, including aplastic anemia, myeloproliferative neoplasms and myelodysplastic syndromes. (northwestern.edu)
  • Most importantly, in the future, RDTR/SCF-LVs might completely obviate ex vivo handling and simplify gene therapy for many hematopoietic defects because of their applicability to direct in vivo inoculation. (epfl.ch)
  • Short-hairpin RNA silencing EAR-2 was also introduced into bone marrow cells cultured ex vivo. (springer.com)
  • The survival and fate of hematopoietic progenitor cells in ex vivo system are reported to be dependent on multiple factors such as combination of cytokines cocktails, oxygen tension, and the presence of reactive oxygen intermediates/species (ROS/ROI). (hindawi.com)
  • A Japanese herbal medicine made from ten different herbs, TJ-48 (Juzen-taiho-to or Shi Quan-Da-Bu-Tang), showed positive effect on ex vivo hematopoietic restoration [ 20 ]. (hindawi.com)
  • In patients with myelodysplastic syndrome (MDS), bone marrow cells have an increased predisposition to apoptosis, yet MDS cells outcompete normal bone marrow (BM)-- suggesting that factors regulating growth potential may be important in MDS. (springer.com)
  • Stem cells are immature blood cells that grow to become red blood cells, white blood cells or platelets. (clinicaltrials.gov)
  • The major cause of this syndrome is depletion of immature parenchymal stem cells in specific tissues. (cdc.gov)
  • Bone marrow contains stem cells, which are immature cells that become blood cells. (medlineplus.gov)
  • The number of cDCs ( B ) and macrophages ( C ) in the bone marrow is shown. (jci.org)
  • Bone marrow CD169+ macrophages promote the retention of hemato. (nih.gov)
  • We have provided direct and novel evidence for the migration of bone marrow and HSC cells into the sclera differentiating into macrophages and dendritic cells. (pubmedcentralcanada.ca)
  • Macrophages and dendritic cells are bone marrow derived antigen presenting cells (APC) which serve in the first step of the acquired immune responses. (pubmedcentralcanada.ca)
  • 2011). non-etheless, older hematopoietic cells such as macrophages/monocytes (Chow et al. (researchhunt.com)
  • These results indicate that NPY promotes neuroprotection and restores bone marrow dysfunction from chemotherapy-induced SNS injury through the Y1 receptor in macrophages. (cshl.edu)
  • 5 year results of bmt ctn 0201: Unrelated donor bone marrow is associated with better psychological well-being and less burdensome chronic gvhd symptoms than peripheral blood. (mayoclinic.org)
  • Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow. (ox.ac.uk)
  • In contrast, the small-molecule eltrombopag, a thrombopoietin receptor antagonist, has been very effective in treating thrombocytopenia in patients with bone marrow failure. (sciencemag.org)
  • We investigated lncRNAs in 979 human bone marrow-derived CD34 + cells by single cell RNA sequencing followed by de novo transcriptome reconstruction. (haematologica.org)
  • Following transduction of CD34 + cells, stem and progenitor cells were quantified in clonogenic assays, cytokine-driven expansion cultures, and long-term stromal cocultures. (bloodjournal.org)
  • Bone-marrow haematopoietic-stem-cell niches. (unil.ch)
  • Whether the same is true for mammalian stem cell niches has not been well defined. (rupress.org)
  • Components of stem cell niches have generally been defined in terms of cells and molecular pathways. (rupress.org)
  • In contrast, MPPs and hematopoietic progenitor cells (HPCs) are rapidly proliferating cells with limited and no self-renewal ability, respectively ( 4 ). (amegroups.com)
  • 12-14 However, the use of cell lines may not accurately model the functional effects of AML1-ETO expression, owing to the different complement of transcription factors found in transformed cells versus hematopoietic progenitor cells (HPCs). (bloodjournal.org)
  • G ) Representative flow plot showing the expression of 2 human cDC markers, CD141 for cDC1 and CD1c for cDC2, on human bone marrow cDCs ( n = 3 donors). (jci.org)
  • Bone marrow progenitor cells were collected from 30 allogenic BM donors. (bvsalud.org)
  • Bone marrow is the tissue inside the bones where stem cells are made.Stem cells will be harvested from the blood or bone marrow of genetically matched unrelated donors or partially matched family donors. (clinicaltrials.gov)
  • If they are not available, donors may also be found in national and international bone marrow registries. (medindia.net)
  • Marrow donors may suffer from complications like pain and discomfort at the site of injection. (medindia.net)
  • Donors administered growth factors prior to harvesting could sometimes undergo complications like bone pain and splenic rupture. (medindia.net)
  • Donors who are not related to you, yet still match, may be found through national bone marrow registries. (medlineplus.gov)
  • A buccal swab can be used for human leukocyte antigen (HLA) typing of bone marrow donors. (medscape.com)
  • Buccal swabs are typically obtained at the time of bone marrow registry enrollment for all potential donors. (medscape.com)
  • A disease that affects the production of bone marrow cells, such as aplastic anemia , congenital neutropenia , severe immune system illnesses, sickle cell anemia , or thalassemia . (medlineplus.gov)
  • Stem Cells for Bone Regeneration: From Cell-Based Therapies to Decellularised Engineered Extracellular Matrices. (semanticscholar.org)
  • Led by an epoch-making research on myocardial regeneration using c-kit-positive bone marrow cells [ 10 ], clinical usage of hematopoietic cells or endothelial progenitor cells for cardiac diseases has been continued since 2002 [ 11 , 12 ]. (hindawi.com)
  • Ablation of cDCs was associated with an expansion of bone marrow endothelial cells and increased vascular permeability. (jci.org)
  • CXCR2 expression in sinusoidal endothelial cells and the expression of 2 CXCR2 ligands, CXCL1 and CXCL2, in the bone marrow were markedly increased following cDC ablation. (jci.org)
  • Endothelial stem cells (ESCs) are one of three types of stem cells found in bone marrow. (wikipedia.org)
  • Important signaling factors for vasculogenesis are TGF-β, BMP4, and VEGF, all of which promote pluripotent stem cells to differentiate into mesoderm, endothelial progenitor cells, and then into mature endothelium. (wikipedia.org)
  • The induction of residual bone marrow injury is primarily attributed to the induction of hematopoietic cell senescence by ionizing radiation. (nih.gov)
  • The activation was associated with a significant reduction in hematopoietic cell clonogenic function, an increased expression of p16(INK4a) (p16), and an elevated senescence-associated β-galactosidase (SA-β-gal) activity. (nih.gov)
  • The majority of bone marrow dendritic cells have a cDC2-like phenotype, are enriched in the perivascular region, and have a unique RNA expression profile. (jci.org)