Bone marrow diseases. Medical search

Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.

The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.

Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.

A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.

A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.

The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.

Removal of bone marrow and evaluation of its histologic picture.

Progenitor cells from which all blood cells derive.

The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.

Bone loss due to osteoclastic activity.

Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.

The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).

Tumors or cancer located in bone tissue or specific BONES.

Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.

The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.

Diseases of BONES.

A cytologic technique for measuring the functional capacity of stem cells by assaying their activity.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.

Transplantation of an individual's own tissue from one site to another site.

An organism whose body contains cell populations of different genotypes as a result of the TRANSPLANTATION of donor cells after sufficient ionizing radiation to destroy the mature recipient's cells which would otherwise reject the donor cells.

Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.

The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.

A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.

The process of bone formation. Histogenesis of bone including ossification.

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.

The grafting of bone from a donor site to a recipient site.

Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.

Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.

An encapsulated lymphatic organ through which venous blood filters.

Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.

A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.

Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.

An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.

A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.

Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.

Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.

Elements of limited time intervals, contributing to particular results or situations.

Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.

Very large BONE MARROW CELLS which release mature BLOOD PLATELETS.

An immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host; the resulting clinical picture is that of GRAFT VS HOST DISEASE.

Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.

Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.

An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)

Clonal myeloid disorders that possess both dysplastic and proliferative features but are not properly classified as either MYELODYSPLASTIC SYNDROMES or MYELOPROLIFERATIVE DISORDERS.

Longevity, stress response, and cancer in aging telomerase-deficient mice. (1/551)

Telomere maintenance is thought to play a role in signaling cellular senescence; however, a link with organismal aging processes has not been established. The telomerase null mouse provides an opportunity to understand the effects associated with critical telomere shortening at the organismal level. We studied a variety of physiological processes in an aging cohort of mTR-/- mice. Loss of telomere function did not elicit a full spectrum of classical pathophysiological symptoms of aging. However, age-dependent telomere shortening and accompanying genetic instability were associated with shortened life span as well as a reduced capacity to respond to stresses such as wound healing and hematopoietic ablation. In addition, we found an increased incidence of spontaneous malignancies. These findings demonstrate a critical role for telomere length in the overall fitness, reserve, and well being of the aging organism. (+info)

Phase I study of 90Y-labeled B72.3 intraperitoneal administration in patients with ovarian cancer: effect of dose and EDTA coadministration on pharmacokinetics and toxicity. (2/551)

The tumor-associated glycoprotein 72 (TAG-72) antigen is present on a high percentage of tumor types including ovarian carcinomas. Antibody B72.3 is a murine monoclonal recognizing the surface domain of the TAG-72 antigen and has been widely used in human clinical trials. After our initial encouraging studies (M. G. Rosenblum et al., J. Natl. Cancer Inst., 83: 1629-1636, 1991) of tissue disposition, metabolism, and pharmacokinetics in 9 patients with ovarian cancer, we designed an escalating dose, multi-arm Phase I study of 90Y-labeled B72.3 i.p. administration. In the first arm of the study, patients (3 pts/dose level) received an i.p. infusion of either 2 or 10 mg of B72.3 labeled with either 1, 10, 15, or 25 mCi of 90Y. Pharmacokinetic studies demonstrated that concentrations of 90Y-labeled B72.3 persist in peritoneal fluid with half-lives >24 h after i.p. administration. In addition, 90Y-labeled B72.3 was absorbed rapidly into the plasma with peak levels achieved within 48 h, and levels declined slowly thereafter. Cumulative urinary excretion of the 90Y label was 10-20% of the administered dose which suggests significant whole-body retention of the radiolabel. Biopsy specimens of bone and marrow obtained at 72 h after administration demonstrated significant content of the label in bone (0.015% of the dose/g) with relatively little in marrow (0.005% of the dose/g). The maximal tolerated dose was determined to be 10 mCi because of hematological toxicity and platelet suppression. This typically occurred on the 29th day after administration and was thought to be a consequence of the irradiation of the marrow from the bony deposition of the radiolabel. In an effort to suppress the bone uptake of 90Y, patients were treated with a continuous i.v. infusion of EDTA (25 mg/kg/12 h x 6) infused immediately before i.p. administration of the radiolabeled antibody. Patients (3 pts/dose level) were treated with doses of 10, 15, 20, 25, 30, 35, 40, or 45 mCi of 90Y-labeled B72.3 for a total of 38 patients. EDTA administration resulted in significant myeloprotection, which allowed escalation to the maximal tolerated dose of 40 mCi. Dose-limiting toxicity was thrombocytopenia and neutropenia. Studies of plasma and peritoneal fluid pharmacokinetics demonstrate no changes compared with patients without EDTA pretreatment. Cumulative urinary excretion of the radiolabel was not increased in patients pretreated with EDTA compared with the untreated group. However, analysis of biopsy specimens of bone and marrow demonstrated that bone and marrow content of the 90Y label was 15-fold lower (<0.001% injected dose/g) than a companion group without EDTA. Four responses were noted in patients who received 15-30 mCi of 90Y-labeled B72.3 with response durations of 1-12 months. These results demonstrate the myeloprotective ability of EDTA, which allows safe i.p. administration of higher doses of 90Y-labeled B72.3 and, therefore, clearly warrant an expanded Phase II trial in patients with minimal residual disease after standard chemotherapy or for the palliation of refractory ascites. (+info)

Double-blind randomized study on the myeloprotective effect of melatonin in combination with carboplatin and etoposide in advanced lung cancer. (3/551)

A significant myeloprotective effect of melatonin in mice treated with etoposide, cyclophosphamide or carboplatin has been reported. The present study was designed to evaluate if the same effect could be observed in patients receiving chemotherapy. Twenty previously untreated patients with inoperable lung cancer received two cycles of carboplatin (given at area under the curve 5 by the Calvert formula) on day 1 and etoposide (150 mg m(-2) i.v.) on days 1-3 every 4 weeks. Melatonin 40 mg or placebo (double-blind) was given orally in the evening for 21 consecutive days, starting 2 days before chemotherapy. Patients were randomized to receive melatonin either with the first or the second cycle. Complete blood cell count with differential was done three times per week for 3 weeks. The median age of the cohort was 60 years (range 42-69), 16 patients had non-small cell and four patients small-cell lung cancer, 12 stage III and eight stage IV disease. In a multivariate analysis including age, sex, diagnosis, stage, performance status, doses of carboplatin and etoposide, and concomitant treatment with melatonin or placebo, the haematological parameters--depth and duration of toxicity for haemoglobin, platelets and neutrophils (ANC)--were not significantly different between cycles with/without melatonin. The mean ANC nadir and the mean number of days with ANC < 0.5 x 10(9) l(-1) were 0.5 x 10(9) l(-1) and 2.5 days, respectively, with/without melatonin. We concluded that, in patients with lung cancer, melatonin given orally at a dose of 40 mg per day for 21 days in the evening, does not protect against the myelotoxic effect of carboplatin and etoposide. (+info)

Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals progression of erosions despite clinical improvement. (4/551)

OBJECTIVES: To investigate the progression of joint damage in early rheumatoid arthritis (RA) using magnetic resonance imaging (MRI) of the wrist and determine whether this technique can be used to predict prognosis. METHODS: An inception cohort of 42 early patients has been followed up prospectively for one year. Gadolinium enhanced MRI scans of the dominant wrist were obtained at baseline and one year and scored for synovitis, tendonitis, bone marrow oedema, and erosions. Plain radiographs were performed concurrently and scored for erosions. Patients were assessed clinically for disease activity and HLA-DRB1 genotyping was performed. RESULTS: At one year, MRI erosions were found in 74% of patients (31 of 42) compared with 45% at baseline. Twelve patients (28.6%) had radiographic erosions at one year. The total MRI score and MRI erosion score increased significantly from baseline to one year despite falls in clinical measures of inflammation including erythrocyte sedimentation rate (ESR), C reactive protein (CRP), and swollen joint count (p < 0.01 for all). Baseline findings that predicted carpal MRI erosions at one year included a total MRI score of 6 or greater (sensitivity: 93.3%, specificity 81.8%, positive predictive value 93.3%, p = 0.000007), MRI bone oedema (OR = 6.47, p < 0.001), MRI synovitis (OR = 2.14, p = 0.003), and pain score (p = 0.01). Radiological erosions at one year were predicted by a total MRI score at baseline of greater than 13 (OR = 12.4, p = 0.002), the presence of MRI erosions (OR = 11.6, p = 0.005), and the ESR (p = 0.02). If MRI erosions were absent at baseline and the total MRI score was low, radiological erosions were highly unlikely to develop by one year (negative predictive value 0.91 and 0.92 respectively). No association was found between the shared epitope and erosions on MRI (p = 0.4) or radiography (p = 1.0) at one year. CONCLUSIONS: MRI scans of the dominant wrist are useful in predicting MRI and radiological erosions in early RA and may indicate the patients that should be managed aggressively. Discordance has been demonstrated between clinical improvement and progression of MRI erosion scores. (+info)

Hematopoietic damage prior to PBSCT and its influence on hematopoietic recovery. (5/551)

BACKGROUND AND OBJECTIVE: Patients with malignancies receive chemotherapy to induce tumor remission which could damage hematopoiesis and adversely influence hematopoietic reconstitution after transplantation. In the present study we used a long-term culture (LTBMC) system and clonogenic assays to evaluate the marrow damage in patients selected to receive peripheral blood stem cell transplantation (PBSCT). DESIGN AND METHODS: Thirty-five patients - 20 with breast cancer (BC), 9 with non-Hodgkin's lymphoma (NHL) and 6 with Hodgkin's disease (HD) - were included. Bone marrow aspiration was performed one day prior to the initiation of the conditioning therapy. CFU-GM were cultured in methylcellulose with PHA-LCM. Delta assays of plastic adherent progenitor cells (PD) were performed according to Gordon's method. LTBMC were established for 5 weeks. RESULTS: There were fewer CFU-GM from all patient groups than from normal BM (p<0.05). In contrast, the number of immature progenitor cells (PD) was not decreased. The total number of CFU-GM produced by LTBMC patients was significantly reduced (p<0.05). The adherent layer from patients was often qualitatively different. In order to know whether the hematopoietic damage could affect hematopoietic reconstitution, we correlated culture data with time taken to reach peripheral cell counts. A negative correlation (r= - 0.71) was found between percentage of stromal layer and time taken to reach 20x10(9) platelets/L (tplat= 20x3-0.08% stromal layer). INTERPRETATION AND CONCLUSIONS: We can conclude that prior to PBSCT, hematopoietic function is impaired at both the level of committed progenitor cells and that of BM stroma. This damage could influence platelet recovery. (+info)

First-line high-dose sequential chemotherapy with rG-CSF and repeated blood stem cell transplantation in untreated inflammatory breast cancer: toxicity and response (PEGASE 02 trial). (6/551)

Despite the generalization of induction chemotherapy and a better outcome for chemosensitive diseases, the prognosis of inflammatory breast cancer (IBC) is still poor. In this work, we evaluate response and toxicity of high-dose sequential chemotherapy with repeated blood stem cell (BSC) transplantation administered as initial treatment in 100 women with non-metastatic IBC. Ninety-five patients (five patients were evaluated as non-eligible) of median age 46 years (range 26-56) received four cycles of chemotherapy associating: cyclophosphamide (C) 6 g m(-2) - doxorubicin (D) 75 mg m(-2) cycle 1, C: 3 g m(-2) - D: 75 mg m(-2) cycle 2, C: 3 g m(-2) - D: 75 mg m(-2) - 5 FU 2500 mg m(-2) cycle 3 and 4. BSC were collected after cycle 1 or 2 and reinfused after cycle 3 and 4. rG-CSF was administered after the four cycles. Mastectomy and radiotherapy were planned after chemotherapy completion. Pathological response was considered as the first end point of this trial. A total of 366 cycles of chemotherapy were administered. Eighty-seven patients completed the four cycles and relative dose intensity was respectively 0.97 (range 0.4-1.04) and 0.96 (range 0.25-1.05) for C and D. Main toxicity was haematological with febrile neutropenia ranging from 26% to 51% of cycles; one death occurred during aplasia. Clinical response rate was 90% +/- 6%. Eighty-six patients underwent mastectomy in a median of 3.5 months (range 3-9) after the first cycle of chemotherapy; pathological complete response rate in breast was 32% +/- 10%. All patients were eligible to receive additional radiotherapy. High-dose chemotherapy with repeated BSC transplantation is feasible with acceptable toxicity in IBC. Pathological response rate is encouraging but has to be confirmed by final outcome. (+info)

Ticlopidine and clopidogrel. (7/551)

The thienopyridines ticlopidine and clopidogrel are inhibitors of platelet function in vivo. Their mode of action has not been defined, but it appears that they require conversion to as yet unidentified metabolites that are noncompetitive antagonists of the platelet ADP receptor. Inhibition of platelet aggregation with these compounds is delayed until 24 to 48 hours after administration. Maximum inhibition occurs after 3 to 5 days, and recovery is slow after drug withdrawal. Ticlopidine is effective in preventing cardiovascular events in cerebrovascular, cardiovascular, and peripheral vascular disease, with an efficacy that is similar to aspirin. However, its use is associated with significant and sometimes fatal adverse reactions, specifically neutropenia and bone marrow aplasia. Gastrointestinal side effects and skin rashes are common and result in discontinuation of therapy in up to 10% of patients. Clopidogrel is at least as effective as aspirin in preventing cardiovascular events in patients with a history of vascular disease. It appears to be safer than ticlopidine, although its efficacy in acute coronary syndromes or post-coronary-stent insertion has not been reported. Important outstanding issues are whether clopidogrel adds to the benefit of aspirin and whether the combination of these agents is safe. If so, this combination may become the standard for antithrombotic therapy in cardiovascular disease. (+info)

Measurement of vitamin B12-binding proteins of plasma. II. Interpretation of patterns in disease. (8/551)

The technique described in the preceding paper was applied to 12 abnormal sera selected for their increase in one or more B12-binding proteins. Even in the presence of large amounts of R-type binder, the ammonium sulfate technique gave a reliable separation of R binding proteins from TC II. Measurement of the TC II in abnormal sera gave results identical to those obtained by the more standard gel filtration. The R binders of four subjects with myeloproliferative disease were further separated into alpha2-R and alpha1-R. The pattern of B12 binding of polycythemia vera (PV) was an exaggeration of the normal pattern. Binding to alpha2-R was three to four times that to alpha1-R, although the total amounts bound to both were increased. In chronic myelogenous leukemia (CML), both alpha2-R and alpha1-R were also increased, but in contrast to binding in normal sera, alpha1-R predominated. In order to interpret the findings, either whole serum R or alpha1-R and alpha2-R from patients with myeloproliferative disease were subject to isoelectric focusing. Alpha2-R consisted pricipally of components isoelectric at pH 2.9, 3.0, and 3.1. These components were present in only minor amounts in normal serum and were somewhat increased in the serum of PV. These components were very much increased in the serum of CML and predominated. Alpha2-R consisted of those components isoelectric at pH 3.4,3.6, and 4.0. These components predominated in the unsaturated binding capacity of normal sera and that of PV. It was concluded that the division of plasma R binders into alpha1-R and alpha1-R by the technique described provided information useful in the study of myeloproliferative diseases. (+info)

1987). "Bone marrow transplantation in the treatment of alpha-mannosidosis". Disease in Childhood. 62 (10): 1044-1049. doi: ... The course of the disease is progressive.[2][8] Depending on the severity of the disease, alpha-mannosidosis has been ... Enzyme replacement therapy (ERT) is a therapeutic alternative in a number of lysosomal storage diseases.[2][7] The overall ... Identification of disease-causing mutations is achieved using DNA from peripheral blood cells, by polymerase chain reaction ( ...

https://en.wikipedia.org/wiki/Alpha-mannosidosis

... some patients still develop diseases because of this interference with bone marrow.[citation needed] ... Krumbhaar EB (1919). "Role of the blood and the bone marrow in certain forms of gas poisoning". JAMA. 72: 39-41. doi:10.1001/ ... A disease resulting from aggressive chemotherapy". Diseases of the Colon and Rectum. 32 (3): 206-9. PMID 2920627. doi:10.1007/ ... In very severe myelosuppression, which occurs in some regimens, almost all the bone marrow stem cells (cells that produce white ...

https://en.wikipedia.org/wiki/Chemotherapeutics

... inflammatory responses within the bone marrow are believed to foster many hematological diseases. The secretion of IL-6 by bone ... July 1994). "Bone marrow angiogenesis and progression in multiple myeloma". Br. J. Haematol. 87 (3): 503-8. doi:10.1111/j.1365- ... They discovered increased bone marrow angiogenesis correlates with myeloma growth and supporting stromal cells are a ... It is believed that they work through different mechanisms in various diseases. The net effect is probably due to different ...

https://en.wikipedia.org/wiki/Development_of_analogs_of_thalidomide

Kidney diseases that are unique to bone marrow transplant (aka Stem Cell Transplant or SCT) are frequently seen in cancer ... Bone marrow transplant related kidney diseases 9. Radiation Nephropathy 10. Tumor Lysis Syndrome 11. Acute Kidney injury in the ... Obstructive renal disease 16. Chronic Kidney disease after chemotherapy induced AKI 17. Renal cell cancer 18. CKD following ... The most common form of kidney disease in cancer patients is acute kidney injury (AKI) which can usually be due to volume ...

https://en.wikipedia.org/wiki/Onconephrology

"Paediatric Immunology, Bone Marrow Transplantation and Infectious Diseases". Newcastle Hospitals. Retrieved 15 April 2018. "The ... The Great North Children's Hospital is one of two units in the UK which perform bone marrow transplants for children who were ...

https://en.wikipedia.org/wiki/Great_North_Children's_Hospital

In 2014, a meta-analysis on stem cell therapy using bone marrow stem cells for heart disease revealed discrepancies in ... Francis, Darrel P (October 2013). "Autologous bone marrow-derived stem cell therapy in heart disease: Discrepancies and ... "Autologous bone marrow-derived stem cell therapy in heart disease: Discrepancies and contradictions". International Journal of ... derived from the bone marrow of adult donors. MSCs are purified from the marrow, cultured and packaged, with up to 10,000 doses ...

https://en.wikipedia.org/wiki/Stem_cell_therapy

Some malignancies that have spread to involve the bone marrow, such as leukemia or advanced Hodgkin's disease, also cause ... Weiss RB, Brunning RD, Kennedy BJ (December 1975). "Hodgkin's disease in the bone marrow". Cancer. 36 (6): 2077-83. doi:10.1002 ... The SARS disease caused lymphocytopenia. Among patients with laboratory-confirmed COVID-19 in Wuhan China through January 29th ... Faguet GB (October 1975). "Quantitation of immunocompetence in Hodgkin's disease". The Journal of Clinical Investigation. 56 (4 ...

https://en.wikipedia.org/wiki/Lymphocytopenia

Some ultimate effects of this disease include bone-marrow failure as well as cancer. This syndrome has been shown to arise from ... Spinal muscular atrophy affects up to 1 in 6,000 people and is the second leading cause of neuromuscular disease, after ... RNPs we have been able to better understand many important diseases. Spinal muscular atrophy - Mutations in the survival motor ...

https://en.wikipedia.org/wiki/Small_nuclear_RNA

Albert Niemann (1880-1921). Pick's cell: Histiocyte found in the spleen and bone marrow in Niemann-Pick disease. It is similar ... ISBN 0-930405-26-9. Medicine.net Definition of Niemann-Pick disease Ludwig Pick at Who Named It Media related to Ludwig Pick ( ... Ludwig Pick made several contributions to academic pathology, particularly in the field of genitourinary diseases, and also in ... Die Skelettform-ossuäre Form des Morbus Gaucher, 1927 - The skeletal form in regards to Gaucher's disease. Der Paratyphus, 1928 ...

https://en.wikipedia.org/wiki/Ludwig_Pick

... a major risk-factor for veno-occlusive disease in the liver after allogeneic bone marrow transplantation". Blood. 92 (12): 4568 ... norethisterone should not be given to patients undergoing allogeneic bone marrow transplantation, as it has been associated ... High-dose (10 mg/day) norethisterone has been associated with hepatic veno-occlusive disease, and because of this adverse ...

https://en.wikipedia.org/wiki/Norethindrone

Overall, the strategy is to control bone marrow and systemic (whole-body) disease, while offering specific treatment for the ... Blood tests, bone marrow biopsy[2]. Treatment. Chemotherapy, radiation therapy, targeted therapy, bone marrow transplant, ... Damage to the bone marrow, by way of displacing the normal bone marrow cells with higher numbers of immature white blood cells ... Management of ALL is directed towards control of bone marrow and systemic (whole-body) disease. Additionally, treatment must ...

https://en.wikipedia.org/wiki/Leucemia

It progresses to a more generalized disease affecting the lymph nodes, bone marrow and spleen.[11] Other signs and symptoms ... Other histiocytic diseases in Bernese Mountain Dogs[edit]. A similar disease is diffuse histiocytic sarcoma, a term used to ... A histiocyte is a differentiated tissue cell that has its origin in the bone marrow. The source for histiocytes is the monocyte ... Invasion of the bone marrow can cause pancytopenia.[8] Diagnosis requires a biopsy. ...

https://en.wikipedia.org/wiki/Malignant_histiocytosis

An allogenic bone marrow transplant can result in an immune attack, called graft-versus-host disease. Informed consent is ... Liver transplants Kidney transplants Pancreas transplantation Islet cell transplantation Bone marrow transplants Bone allograft ... Allogeneic stem cell transplantation entry in the public domain NCI Dictionary of Cancer Terms Allogeneic bone marrow ... Allograft diseases Medical grafting Surgery For ACL Tears (W. P. Longmire, J. National Cancer Institute 14, 669: The term ...

https://en.wikipedia.org/wiki/Allotransplantation

An allogenic bone marrow transplant can result in an immune attack, called graft-versus-host disease. ... Allogeneic bone marrow transplantation entry in the public domain NCI Dictionary of Cancer Terms ... W. P. Longmire, J. National Cancer Institute 14, 669: The term homostatic graft might be applied to inert tissues such as bone ... Screening for pathology and risk factors for communicable diseases such as HIV and Hepatitis B and C is then conducted.[ ...

https://en.wikipedia.org/wiki/Allografts

Nakao K, Fujioka S (1968). "Thymidine kinase activity in the human bone marrow from various blood diseases". Life Sciences. 7 ( ... Wickramasinghe SN, Olsen I, Saunders JE (1975). "Thymidine kinase activity in human bone marrow cells". Scandinavian Journal of ... This disease has a wide range of aggressivity, from slow-growing indolent disease that hardly requires treatment to highly ... in peripheral lymphocytes during monocytosis and in bone marrow during pernicious anemia. As TK1 is present in cells during ...

https://en.wikipedia.org/wiki/Thymidine_kinase_in_clinical_chemistry

Nakao K, Fujioka S (April 1968). "Thymidine kinase activity in the human bone marrow from various blood diseases". Life ... Wickramasinghe SN, Olsen I, Saunders JE (September 1975). "Thymidine kinase activity in human bone marrow cells". Scandinavian ... in peripheric lymphocytes during monocytosis and in bone marrow during pernicious anemia. As TK1 is present in cells during ... Enzymes of thymidine and thymidylate metabolism in normal and pathological blood and bone marrow cells]". Blut (in German). 25 ...

https://en.wikipedia.org/wiki/Thymidine_kinase

In September 2012 Pluristem reported saving the life of a third bone marrow disease patient using its PLacental eXpanded cell ... "Pluristem stem cells save 3rd bone marrow disease patient". Globes. 5 September 2012. Retrieved 10 September 2012. "Israeli ... cells were injected into the muscles of a 7-year-old Romanian girl undergoing treatment for bone marrow aplasia disease at the ... Two months thereafter, with the patient's condition deteriorating rapidly, the Director of Bone Marrow Transplantation, Cell ...

https://en.wikipedia.org/wiki/Pluristem_Therapeutics

... some people still develop diseases because of this interference with bone marrow.[citation needed] Although people receiving ... ISBN 978-1-60795-014-1. Krumbhaar EB (1919). "Role of the blood and the bone marrow in certain forms of gas poisoning". JAMA. ... Virtually all chemotherapeutic regimens can cause depression of the immune system, often by paralysing the bone marrow and ... The drug is given before chemotherapy to protect bone marrow function. Due to immune system suppression, neutropenic ...

https://en.wikipedia.org/wiki/Chemotherapy

Also, some diseases related to hematopoietic system, such as aplastic anemia and complete bone marrow failure, are not ... Diseases such as Alzheimer's disease, end-stage renal failure and heart disease are caused by different mechanisms that are not ... 1999). "Evidence for a continuous decline in hematopietic cell function from birth: application to evaluating bone marrow ... Smith J., A., Daniel R. "Stem Cells and Aging: A Chicken-Or-Egg Issue?". Aging and Disease. 2012 Jun, Vol. 3, Number 3; 260-268 ...

https://en.wikipedia.org/wiki/Stem_cell_theory_of_aging

He died in 1979 aged 40 from bone marrow disease. In young adulthood, Medina worked as a secretary in the Lima clinic of Lozada ...

https://en.wikipedia.org/wiki/Lina_Medina

She was diagnosed with bone marrow cancer in 1960 and died of the disease on 7 December 1962. At her own request she was buried ...

https://en.wikipedia.org/wiki/Kirsten_Flagstad

"The Use of Nitrogen Mustard in Neoplastic Diseases of the Bone Marrow," Rev. Med. Liban. I (1961?): 45-51. (with E. Stephan) " ... with G.I. Abu-Haydar and N.A. Abu-Haydar) "Thalassemia Hemoglobin E. Disease. A Case Report from Quatar." Persian Gulf, Man., ... with N.A. Abu-Haydar) "Sickle Cell Disease in Lebanon and Syria." Acta Haemat., Basel XXVII (1962):268-273. ( ...

https://en.wikipedia.org/wiki/Munib_Shahid

... inflammatory responses within the bone marrow are believed to foster many hematological diseases. The secretion of IL-6 by bone ... July 1994). "Bone marrow angiogenesis and progression in multiple myeloma". Br. J. Haematol. 87 (3): 503-8. doi:10.1111/j.1365- ... They discovered increased bone marrow angiogenesis correlates with myeloma growth and supporting stromal cells are a ... The primary use of IMiDs in medicine is in the treatment of cancers and autoimmune diseases (including one that is a response ...

https://en.wikipedia.org/wiki/Immunomodulatory_imide_drug

... chronic granulomatous disease). In addition, diseases affecting the bone marrow may result in abnormal or few leukocytes. ... Diabetes, cardiovascular disease, allergies, and chronic obstructive pulmonary disease (COPD) are examples of diseases mediated ... Acne vulgaris Asthma Autoimmune diseases Autoinflammatory diseases Celiac disease Chronic prostatitis Colitis Diverticulitis ... Non-immune diseases with causal origins in inflammatory processes include cancer, atherosclerosis, and ischemic heart disease. ...

https://en.wikipedia.org/wiki/Inflammation

He had been suffering from bone marrow disease for two years. He was laid to rest at the Zincirlikuyu Cemetery following the ...

https://en.wikipedia.org/wiki/Orhan_Boran

... though bone marrow transplant was suggested as a treatment during early RCD2. Bone marrow involvement is rare in this disease.[ ... In treated coeliacs, EATL may be preceded by refractory coeliac disease 1(RCD1) or, prominently, refractory celiac disease 2 ( ... Type II doesn´t show these associations and frequently presents with bulky disease. Early recognition of coeliac disease, ... See Coeliac Disease, HLA-DQ, HLA DR3-DQ2) A DQ isoform that appears to be responsible for EATL in the overwhelming number of ...

https://en.wikipedia.org/wiki/Enteropathy-associated_T-cell_lymphoma

Stem cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplantation is a widely ... Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation In National Cancer Institute Fact Sheet web site. ... Parkinson's disease and Alzheimer's disease.[70] The Human Fertilisation and Embryology Act 2008, a major review of fertility ... Research is underway to potentially use stem cell therapy to treat heart disease, diabetes, and spinal cord injuries.[29][30] ...

https://en.wikipedia.org/wiki/Human_Cloning

749 Those who are at risk of developing graft-versus-host disease, such as bone marrow transplant recipients, receive blood ... "Abo Compatibility and Acute Graft-Versus-Host Disease Following Allogeneic Bone Marrow Transplantation". Transplantation. 45 (6 ... if they have received a bone marrow or stem cell transplant from someone with a different blood type, or in patients with ... If IgG is bound to red blood cells in vivo, as may occur in autoimmune hemolytic anemia, hemolytic disease of the newborn and ...

https://en.wikipedia.org/wiki/Blood_compatibility_testing

Bob DeWeese died on November 20, 1990 from bone marrow disease in Billings. He continued making art up until his death. Montana ...

https://en.wikipedia.org/wiki/Bob_DeWeese_(artist)

These landmark publications have been the basis for the new field of autologous bone marrow stem cell therapy for heart disease ... "Autologous bone marrow-derived stem cell therapy in heart disease: Discrepancies and contradictions". International Journal of ... Strauer, Bodo; Brehm M.; Zeus T (2002). "Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow ... own bone marrow cells into the coronary arteries can increase the pumping efficacy of a weak heart. ...

https://en.wikipedia.org/wiki/Bodo-Eckehard_Strauer

Recently they have been shown to reside for much longer periods in the bone marrow as long-lived plasma cells (LLPC). They ... Role in disease[edit]. Plasmacytoma, multiple myeloma, Waldenström macroglobulinemia and plasma cell leukemia are malignant ... After leaving the bone marrow, the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which ... Plasma cells originate in the bone marrow; B cells differentiate into plasma cells that produce antibody molecules closely ...

https://en.wikipedia.org/wiki/Plasma_cells

... bone marrow transplantation, and HIV-1 infection. Annual Review of Immunology. 2000, 18: 529-560. ISSN 0732-0582. PMID 10837068 ... Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease. Immunology. May 2016, 148 ( ... Modulation of autoimmune diseases by interleukin (IL)-17 producing regulatory T helper (Th17) cells. The Indian Journal of ... Immunobiology: the immune system in health and disease 5th ed. New York: Garland Pub. 2001. ISBN 978-0-8153-3642-6. OCLC ...

https://zh.m.wikipedia.org/wiki/T细胞

2009). "Meningioma 1 gene is differentially expressed in CD34 positive cells from bone marrow of patients with myelodysplastic ... 2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078- ...

https://en.wikipedia.org/wiki/MN1_

Bone-marrow Arall. Ffeiliau perthnasol ar Gomin Wicimedia. Mer esgyrn yw'r meinwe hyblyg tu mewn asgwrn. Gyda bodau dynol, mae ... "Research Supports Promise of Cell Therapy for Bowel Disease". Wake Forest Baptist Medical Center. 28 February 2013. http://www. ... wakehealth.edu/News-Releases/2013/Research_Supports_Promise_of_Cell_Therapy_for_Bowel_Disease.htm. Adalwyd 5 March 2013. ... marrow adipocytes and beta-pancreatic islets cells. ...

https://cy.wikipedia.org/wiki/Mer_esgyrn

... implications for bone marrow metastasis". Proceedings of the National Academy of Sciences of the United States of America. 97 ( ... SP concentrations cannot yet be used to diagnose disease clinically or gauge disease severity. It is not yet known whether ... Microbial Toxins and Diarrhoeal Disease. Ciba Found. Symp. 112. pp. 139-54. doi:10.1002/9780470720936.ch8. PMID 2861068.. ... Quantification in diseaseEdit. Elevation of serum, plasma, or tissue SP and/or its receptor (NK1R) has been associated with ...

https://en.m.wikipedia.org/wiki/Substance_P

The first physician to perform a successful human bone marrow transplant on a disease other than cancer was Robert A. Good at ... "Bone Marrow Transplant" redirects here. For the journal abbreviated Bone Marrow Transplant, see Bone Marrow Transplantation ( ... Bone marrow transplantation usually requires that the recipient's own bone marrow be destroyed (myeloablation). Prior to the ... Thomas' work showed that bone marrow cells infused intravenously could repopulate the bone marrow and produce new blood cells. ...

https://en.wikipedia.org/wiki/Bone_Marrow_Transplant

"Bone Marrow Res 2012: 787414. PMC 3398573. PMID 22830032. *↑ William JB; Prabakaran, Rajamanickam; Ayyappan, Subbu (2011). " ... Lindvall O (2003). "Stem cells for cell therapy in Parkinson's disease". Pharmacol Res 47 (4): 279-87. PMID 12644384. ... 2006). "Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy". Stem ... "P-Selectin coated microtube for enrichment of CD34+ hematopoietic stem and progenitor cells from human bone marrow". Clin Chem ...

https://et.wikipedia.org/wiki/Tüvirakud

... s are progenitor cells that arise from mesenchymal stem cells (MSC) in the bone marrow. They have ... The results of this research was used as a model for Kashin-Beck disease. Kashin-Beck is a result of combinatorial ... before any genetic or morphological criteria were put in place for bone marrow or connective tissues. Osteoprogenitor cells can ... "Journal of Bone and Mineral Research. 22 (8): 1245-1259. doi:10.1359/jbmr.070420. PMID 17456009.. ...

https://en.wikipedia.org/wiki/Osteochondroprogenitor_cell

The organization hosts events throughout the year to support the hematology/oncology/bone marrow transplant unit[71] at ... a research institute for cardiovascular disease. ...

https://en.m.wikipedia.org/wiki/The_Ohio_State_University

liver, bone marrow, and lymphatic organs FunctionEdit. Connective tissue has a wide variety of functions that depend on the ... Mixed connective tissue disease - a disease of the autoimmune system, also undifferentiated connective tissue disease. ... Bind bones and other tissues to each other. Alpha polypeptide chains. tendon, ligament, skin, cornea, cartilage, bone, blood ... "Nutrition, Metabolism and Cardiovascular Diseases. 17 (2): 125-139. doi:10.1016/j.numecd.2006.10.005. PMC 4426988. PMID ...

https://en.m.wikipedia.org/wiki/Fibrous_connective_tissue

Jude is the first known hospital in the world to cure sickle cell disease through bone marrow transplantation. Today, bone ... marrow transplantation still offers the only cure for sickle cell disease. Members of Kappa Alpha Psi reach out to churches in ... Since that time, members across the country have joined in the fight against pediatric cancer, sickle cell disease, and other ... is a pediatric treatment and research facility focused on children's catastrophic diseases, particularly leukemia and other ...

https://en.m.wikipedia.org/wiki/St._Jude_Children’s_Research_Hospital

L. Michaels (1987). Normal Anatomy, Histology; Inflammatory Diseases. Springer London. ISBN 9781447133322. .. ... Bone marrow. *Hematopoietic stem cell. Thymus. *Hassall's corpuscles. Secondary organs. Spleen. *Structure *Hilum ...

https://en.wikipedia.org/wiki/Tonsil

... which is the organ essential for T-cell maturation following the migration of precursor cells from the bone marrow. This age- ... Ginaldi, L.; M.F. Loreto; M.P. Corsi; M. Modesti; M. de Martinis (2001). "Immunosenescence and infectious diseases". Microbes ... "Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice ... This has been implicated in the increasing frequency and severity of diseases such as cancer, chronic inflammatory disorders, ...

https://en.wikipedia.org/wiki/Immunosenescence

Then he sutured them together and attached them to the stump of bone to keep them from retracting.[16] This is the first known ... Gift of Life Marrow Registry. *Human Tissue Authority. *LifeSharers. *National Marrow Donor Program ... Surgeons usually connect the bones first, followed by tendons, arteries, nerves, veins, and skin. ... Graft-versus-host disease. *Post-transplant lymphoproliferative disorder. *Transplant rejection. Transplant networks. and ...

https://en.wikipedia.org/wiki/Hand_transplantation

... is a biological treatment option for articular cartilage damage bone marrow stimulating technique in combination with a ... "Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells ... using tissue engineering with a scaffold derived from a rat meniscus and mesenchymal stromal cells derived from rat bone marrow ... Osteoarthritis is a common condition of cartilage failure that can lead to limited range of motion, bone damage and invariably ...

https://en.wikipedia.org/wiki/Knee_cartilage_replacement_therapy

... bone marrow - bone marrow suppression - booster - branched DNA assay - breakthrough infection - Broadway Cares/Equity Fights ... efficacy - empirical - encephalitis - end-stage disease - endemic - endogenous - endoscopy - endotoxin - endpoint - enteric - ... NAT - National Cancer Institute (NCI) - National Institute of Allergy and Infectious Diseases (NIAID) - National Institute of ... HIV disease - HIV prevention trials network (HPTN) - HIV set point - HIV vaccine trials network (HVTN) - HIV-1 - HIV-2 - HIV- ...

https://en.m.wikipedia.org/wiki/Index_of_AIDS-related_topics

Miscellaneous - ECMO, kidney or bone marrow transplant, hemodialysis, kidney failure, severe burn, celiac disease, severe acute ... increase of production in bone marrow, increased release from storage in bone marrow, decreased attachment to veins and ... All white blood cells are produced and derived from multipotent cells in the bone marrow known as hematopoietic stem cells. ... Increased destruction of cells in peripheral circulation can stimulate bone marrow. This can occur in hemolytic anemia and ...

https://en.wikipedia.org/wiki/Immune_cell

Bone Marrow Transplant». ucsfchildrenshospital.org.. *↑ Ed Kane. «Stem-cell therapy shows promise for horse soft-tissue injury ... Vastag B (2001). "Stem Cells Step Closer to the Clinic: Paralysis Partially Reversed in Rats with ALS-like Disease". JAMA: The ... "Application of autologous bone marrow mononuclear cells in six patients with advanced chronic critical limb ischemia as a ... Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation In National Cancer Institute Fact Sheet web site. ...

https://lv.wikipedia.org/wiki/Cilmes_šūna

Bone marrow transplant may be possible for Severe Combined Immune Deficiency and other severe immunodeficiences. Virus-specific ... Chronic granulomatous disease: autosomal (NCF1) Chronic granulomatous disease: autosomal (NCF2) IL-12 and IL-23 β1 chain ... June 2008). "Stem cell transplantation for primary immunodeficiencies". Bone Marrow Transplant. 41 Suppl 2: S83-6. doi:10.1038/ ... Such donor T-cells often cause acute graft-versus-host disease (GVHD), a subject of ongoing investigation. VSTs have been ...

https://en.wikipedia.org/wiki/Primary_immunodeficiency

This agent also causes respiratory tract lesions, bone marrow depression, and eye damage, the epithelial tissues of these ... 2008) Agricultural lung diseases. Environ Health Perspect 108:705-12. Hlastala MP, Ralph DD, Babb AL, Influence of gas physical ... Secondary effects of sulfur mustard exposure lead to chronic lung diseases such as chronic bronchitis. A common exposure ... 2011) Sarcoid like granulomatous pulmonary disease in World Trade Center disaster responders. Am J Ind Med. 54:175-84. Banauch ...

https://en.wikipedia.org/wiki/Acute_inhalation_injury

For a long time, the most efficient approach had been to use bone marrow graft, or hematopoietic stem cell transplantation. ... Hunter syndrome is one of several related lysosomal storage diseases called the MPS diseases. In Hunter syndrome, GAGs build up ... Because of all these reasons, bone marrow grafts or hematopoietic stem cell transplantation have seen a decrease in their ... the effects of even mild disease are quite serious. Between the two main forms of disease, and even within them, two of the ...

https://en.wikipedia.org/wiki/Hunter_syndrome

"Effect of homologous bone marrow injections in x-irradiated rabbits". British Journal of Experimental Pathology. 38 (4): 401- ... is a DNA sequence that causes disease or is associated with susceptibility to disease. They can be used to create genetic maps ... It can also be a substance whose detection indicates a particular disease state, for example, the presence of an antibody may ... a biomarker indicates a change in expression or state of a protein that correlates with the risk or progression of a disease, ...

https://en.m.wikipedia.org/wiki/Biomarkers

KK Ballen, F Verter and J Kurtzberg Umbilical cord blood donation: public or private? Bone Marrow Transplantation (2015), 1-8 ... http://www.nationalcordbloodprogram.org/patients/ncbp_diseases.htm. *↑ http://www.bmdw.org/ (Online) prístup: 18.12.2008 ... Increased migration of cord blood-derived CD34+ cells, as compared to bone marrow and mobilized peripheral blood CD34+ cells ...

https://sk.wikipedia.org/wiki/Pupočníková_krv

They are usually the first cells to arrive at the site of an infection.[5] The bone marrow of a normal healthy adult produces ... Stvrtinová, Viera; Ján Jakubovský and Ivan Hulín (1995). Inflammation and fever; from Pathophysiology: principles of disease. ... They are produced by blood-forming stem cells in the bone marrow.[1] ...

https://simple.wikipedia.org/wiki/Innate_immune_system

ද්‍රව තරල පිටතට ගෙන පරීක්‍ෂා කිරීම(Bone Marrow Biopsy FNAC) වැනි පරීක්‍ෂණ මගින් පිළිකා කල් තබා හදුනා ගත හැක. ... GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators. (8 October 2016). "Global, regional, and national ... a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1545-1602. doi:10.1016/S0140-6736(16) ... a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1459-1544. doi:10.1016/s0140-6736(16) ...

https://si.wikipedia.org/wiki/පිළිකා

"Bone Marrow Transplantation. 31: 411-412. doi:10.1038/sj.bmt.1703857.. Pemeliharaan CS1: Banyak nama: authors list (link) ... Paul H. Jacobs, Lexie Nall (1996). Fungal disease: biology, immunology, and diagnosis. Informa Healthcare. ISBN.. ... G.P. Munkvold (2003). "Epidemiology of Fusarium diseases and their mycotoxins in maize ears". European journal of plant ... Penyakit lain yang dapat diakibatkan oleh Fusarium adalah kelayuan atau disebut Fusarium wilt disease, contohnya Fusarium ...

https://id.wikipedia.org/wiki/Fusarium

Campbell was the first to discover that cells of bone marrow origin contribute to intimal (the innermost coat of blood vessels ... in heart diseases). She further determined how these cells could be maintained in the 'non-disease' phenotype. This knowledge ... Her most recent work involves the development of autologous vascular grafts from cells of bone marrow, known as the myeloid, ... This process is undergoing pre-clinical trials in humans and may be used to treat patients suffering coronary heart disease, ...

https://en.wikipedia.org/wiki/Julie_Campbell_(vascular_biologist)

When Roger Bennett was facing his first bone marrow transplant in 2004, Fowler called on Legacy Five supporters for help. He ... died from the disease in March 2007. That left Fowler as the lone owner of Legacy Five. He had to dig down deep to carry on. " ...

https://en.wikipedia.org/wiki/Scott_Fowler

... leukemoid reaction secondary to metastases to the bone marrow, and drug sensitivity, sulfa and valproate toxicities[5] are ... It has also been described in Filovirus disease.[4]. In patients with these conditions, the pseudo-Pelger-Huët cells tend to ... "Outbreake of Marburg virus disease in Johannesburg". British Medical Journal. 4 (5995): 489-93. doi:10.1136/bmj.4.5995.489 ... appear late in the disease and often appear after considerable chemotherapy has been administered. The morphologic changes have ...

https://en.m.wikipedia.org/wiki/Pelger–Huet_anomaly

The bone marrow of a normal healthy adult produces more than 100 billion neutrophils per day, and more than 10 times that many ... "Pathophysiology: Principles of Disease. Computing Centre, Slovak Academy of Sciences: Academic Electronic Press. Archived from ... but are the products of multipotent hematopoietic stem cells present in the bone marrow.[7] ... Main article: Plant disease resistance § Immune system. Members of every class of pathogen that infect humans also infect ...

https://en.wikipedia.org/wiki/Innate_immune_system

Other diseases and disorders of the bone marrow. Other diseases and disorders of the bone marrow include:. * Disorders of ... Metabolic bone disease etc.. * Bone marrow depression may be caused due to cancer chemotherapy, bone marrow transplantation and ... Main bone marrow problems. Diseases of the bone marrow may lead to an abnormality in the production of any of the mature blood ... "Myelo" means bone marrow and MPD signifies proliferation of the bone marrow. These are a group of diseases. ...

https://www.news-medical.net/health/Bone-Marrow-Diseases.aspx

Health Information on Bone Marrow Diseases: MedlinePlus Multiple Languages Collection ... Bone Marrow Diseases: MedlinePlus Health Topic - English Enfermedades de la médula ósea: Tema de salud de MedlinePlus - español ... Bone Marrow Biopsy - 简体中文 (Chinese, Simplified (Mandarin dialect)) Bilingual PDF ... Bone Marrow Biopsy - 繁體中文 (Chinese, Traditional (Cantonese dialect)) Bilingual PDF ...

https://medlineplus.gov/languages/bonemarrowdiseases.html

Bone marrow diseases affect your bodys ability to make healthy blood cells. Learn the different causes and possible treatments ... Causes of bone marrow diseases include genetics and environmental factors. Tests for bone marrow diseases include blood and ... Bone marrow transplant (Medical Encyclopedia) Also in Spanish * Bone marrow transplant - discharge (Medical Encyclopedia) Also ... In aplastic anemia, the bone marrow doesnt make red blood cells. *In myeloproliferative disorders, the bone marrow makes too ...

https://medlineplus.gov/bonemarrowdiseases.html

The Division of Bone Marrow Transplantation and Immune Deficiency at Cincinnati Childrens is a leader in care for hard-to- ... Bone Marrow Transplantation and Immune Deficiency The Division of Bone Marrow Transplantation and Immune Deficiency at ... Our Bone Marrow Transplantation Program. Learn more about our different clinics, the diseases we treat, research efforts, ... Learn more about the conditions we treat, including malignancies, immune deficiencies, bone marrow failure syndromes, ...

https://www.cincinnatichildrens.org/service/c/cancer-blood/bone-marrow-immune-deficiency

Targeting Fibrosis in Kidney, Bone Marrow, and Urological Diseases. Jan. 7, 2014. Location Contacts ... Fibrosis and Prostate Disease. Dr. William Ricke. 12:15 p.m.. Lunch (on your own). A box lunch may be ordered the morning of ... The National Institute of Diabetes and Digestive and Kidney Diseases. Health Information Center ...

https://www.niddk.nih.gov/news/meetings-workshops/2014/targeting-fibrosis-in-kidney-bone-marrow-and-urological-diseases

... were reflected in the bone marrow.. The bone marrows reactions actually fan the flames of the inflammatory bowel diseases ... When bone marrow amps up production of monocytes and neutrophils, it does it at the expense of making lymphocytes and red blood ... Fraker focused on bone marrow, which is a large, highly active, and responsive tissue. When colitis was induced in mice, she ... bowel diseases wreak havoc on the digestive tract and a new study reveals that the damage is mirrored in the bone marrow. ...

https://www.futurity.org/bone-marrow-amps-up-bowel-diseases/

Bone Marrow Transplantation volume 53, pages1048-1050(2018)Cite this article ... Tétu, P., Jachiet, M., de Masson, A. et al. Chronic graft versus host disease presenting as lichen planus pigmentosus. Bone ... Eczematoid graft-vs-host disease: a novel form of chronic cutaneous graft-vs-host disease and its response to psoralen-UV-A ... Histochemical and ultrastructural study of diffuse melanoderma after bone marrow transplantation. Br J Dermatol. 1996;134:325- ...

https://www.nature.com/articles/s41409-018-0110-z?error=cookies_not_supported&code=2be7e728-9f42-4e5d-ae39-5c70dd895070

Create healthcare diagrams like this example called Diseases Treatable with a Bone Marrow or Cord Blood Transplant in minutes ... Diseases Treatable with a Bone Marrow or Cord Blood Transplant. Create healthcare diagrams like this example called Diseases ... Bone Marrow/ Cord Blood Transplant. Sickle cell disease and thalassemia Severe aplastic anemia and other marrow failure states ... Diseases Treatable with a Bone Marrow or Cord Blood Transplant. Familial erythrophagocytic lymphohistiocytosis and other ...

https://www.smartdraw.com/organ-donation/examples/diseases-treatable-with-a-bone-marrow-or-cord-blood-transplant/

... and one patient is alive with progressive bone disease at day 1118. We conclude that among patients with chemotherapy-sensitive ... Twelve patients with metastatic breast carcinoma who had stable disease after standard-dose chemotherapy and six who had a ... Evidence for a graft-versus-tumor effect in a patient treated with marrow ablative chemotherapy and allogeneic bone marrow ... Patients with fulminant progressive disease or recurrent disease after day 30 or residual disease at day 100 were weaned from ...

https://www.nature.com/articles/bmt2009101?error=cookies_not_supported&code=472f583a-d926-4318-9753-548ba193d24d

... often occurs after allogeneic bone marrow transplants (BMT). In GVHD, the donors bone marrow attacks the patients organs and ... Graft-versus-Host disease (GVHD) often occurs after allogeneic bone marrow transplants (BMT). In GVHD, the donors bone marrow ... Bone Marrow Transplant: Acute Graft versus Host Disease (PDF). HH-I-165 3/77, Revised 1/16 Copyright 1977, Nationwide ... Acute GVHD most often occurs in the first 100 days after a bone marrow transplant. The first sign is often a skin rash. It may ...

https://www.nationwidechildrens.org/family-resources-education/health-wellness-and-safety-resources/helping-hands/bone-marrow-transplant-acute-graft-vs-host-disease

Bone marrow is necessary for the transition that stem cells make to become one of the types of blood cells (red blood cells, ... Bone marrow is a soft spongy material that is located inside of the bones. ... Bone pain, an aching of the joints and headaches are all symptoms of bone marrow disease. These types of complaints occur when ... Bone marrow is a soft spongy material that is located inside of the bones. Bone marrow is necessary for the transition that ...

https://www.livestrong.com/article/22162-signs-symptoms-bone-marrow/

Bone Marrow Donor Procedure) and Bone Marrow Donor Procedure What to Read Next on Medscape. Related Conditions and Diseases. * ... Collection of Stem Cells From Bone Marrow. Anesthesia. Most bone marrow donor procedures are performed under general anesthesia ... typing of bone marrow donors. Buccal swabs are typically obtained at the time of bone marrow registry enrollment for all ... typing of bone marrow donors. Buccal swabs are typically obtained at the time of bone marrow registry enrollment for all ...

https://emedicine.medscape.com/article/1948293-overview

Myeloid neoplasms include a spectrum of potentially life-threatening bone marrow disorders, such as myelodysplastic syndromes ... a drug commonly used to treat autoimmune disease, may increase the risk of myeloid neoplasms. ... mayo-clinic-researchers-find-association-between-therapy-for-autoimmune-disease-and-bone-marrow-disorders/. Related Journal ... Association between autoimmune disease and bone marrow disorders. Mayo Clinic. Journal. JAMA Oncology. Keywords. *MEDICINE/ ...

https://www.eurekalert.org/pub_releases/2017-02/mc-mca020217.php

... have launched a Phase I clinical trial of CD34+ bone marrow stem cells (BMSC) for people with retinal conditions that cause ... Bone Marrow Stem Cells in Clinical Trial for Retinal Diseases. April 11, 2013 - Researchers from the University of California, ... Parks study is enrolling people with retinal degenerative diseases, such as retinitis pigmentosa (RP), Stargardt disease and ... Davis (UC Davis), have launched a Phase I clinical trial of CD34+ bone marrow stem cells (BMSC) for people with retinal ...

http://www.blindness.org/bone-marrow-stem-cells-clinical-trial-retinal-diseases

CDK6 »JAK2 »MPN »Malignant bone marrow disease »Toxicology »Veterinary Medicine »blood cells »bone marrow »malignant ... Malignant bone marrow disease , Toxicology , Veterinary Medicine , blood cells , bone marrow , malignant ... Malignant bone marrow disease: New hope for MPN patients. 05.02.2019. Myeloproliferative neoplasms (MPNs) are still difficult ... MPNs are a group of rare, malignant diseases of the bone marrow involving the production of an excess of red blood cells, white ...

https://www.innovations-report.com/html/reports/life-sciences/malignant-bone-marrow-disease-new-hope-for-mpn-patients.html

Bone Marrow indicating that the following substances may be helpful: Ayurvedic formulation: Liv52, Resveratrol, and Flavonoids ... Diseases : DNA damage, Radiation Induced Illness, Radiation Induced Illness: Bone Marrow. Pharmacological Actions : ... Diseases : Inflammation, Radiation Induced Illness, Radiation Induced Illness: Bone Marrow. Pharmacological Actions : Anti- ... Diseases : DNA damage, Radiation Induced Illness, Radiation Induced Illness: Bone Marrow. Pharmacological Actions : ...

https://www.greenmedinfo.com/disease/radiation-induced-illness-bone-marrow

Bone marrow is the spongy tissue inside some of the bones, such as your hip and thigh bones. It contains immature cells called ...

http://www.patient-education.com/englisha/interactive/bone-marrow-diseases

Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases. Official Title ICMJE Bilateral Orthotopic ... Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases (BOLT+BMT). This study is currently ... Incidence of acute and chronic graft-versus-host disease (GVHD) following tandem lung and bone marrow transplant. [ Time Frame ... As a secondary aim after successful engraftment with donor bone marrow, there is realistic hope for tolerating planned ...

https://clinicaltrials.gov/ct2/show/record/NCT01852370

... Madhava Pai,1 Duncan Spalding,1 Feng Xi,1 and Nagy ... "Autologous Bone Marrow Stem Cells in the Treatment of Chronic Liver Disease," International Journal of Hepatology, vol. 2012, ...

https://www.hindawi.com/journals/ijh/2012/307165/cta/

Hematologic Diseases. Disease Attributes. Phagocyte Bactericidal Dysfunction. Genetic Diseases, X-Linked. Genetic Diseases, ... Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases (BOLT+BMT). The safety and scientific ... MedlinePlus related topics: Bone Marrow Transplantation Lung Transplantation Genetic and Rare Diseases Information Center ... Bone Marrow Transplantation. Unrelated Donor. Cadaveric Donor. Deceased Donor. HLA-mismatch. BOLT. BMT. HSCT. ...

https://clinicaltrials.gov/ct2/show/NCT01852370?recr=Open&cond=%22Granulomatous+Disease%2C+Chronic%22&rank=16

... with severe sickle cell disease, according to a study in the July 2 issue of JAMA. ... Use of a lower intensity bone marrow transplantation method showed promising results among 30 patients (16-65 years of age) ... Bone marrow transplantation shows potential for treating adults with sickle cell disease. The JAMA Network Journals ... Bone marrow transplantation shows potential for treating adults with sickle cell disease ...

https://www.eurekalert.org/pub_releases/2014-07/tjnj-bmt062614.php

... to effectively block the development of graft-versus-host disease, a potentially lethal complication of bone marrow stem cell ... Graft-versus-host disease is a risk when patients receive bone marrow stem cells donated from another person. GvHD occurs when ... Monoclonal antibody prevents graft-vs-host disease in bone marrow transplantation model PRO 140 currently in phase 2 clinical ... Monoclonal antibody prevents graft-vs-host disease in bone marrow transplantation model. Bioscribe ...

https://eurekalert.org/pub_releases/2017-11/b-map111317.php

The bone marrow disease myelofibrosis is stimulated by excessive signaling from vitamin D and immune cells known as macrophages ... Tags: Blood, Bone, Bone Marrow, Bone Marrow Disease, Calcium, Cell, Collagen, Diet, Fibrosis, Gene, Genes, Genetic, Genetic ... Bone marrow disease is stimulated by vitamin D and immune cells, reveals research. *Download PDF Copy ... Researchers map bone-marrow microenvironment to shed new light on leukemia. *Vitamin D and estrogen can prevent heart disease, ...

https://www.news-medical.net/news/20190211/Bone-marrow-disease-is-stimulated-by-vitamin-D-and-immune-cells-reveals-research.aspx

... fragility of the bone, or high pressure exerted by doctors on the bone. Contact pressure associated with bone marrow aspiration ... when doctors aspirated the bone marrow. Contact pressure resulting from bone marrow puncture was found to be high; therefore, ... we examined the contact pressure resulting from bone marrow puncture for aspiration. Prescale, a pressure-sensitive film, was ... when doctors aspirated the bone marrow. Contact pressure resulting from bone marrow puncture was found to be high; therefore, ...

https://www.scirp.org/journal/paperinforcitation.aspx?paperid=22220

Managing inherited kidney disease. The discovery that bone-marrow derived stem cells can regenerate damaged renal cells in an ... The disease additionally causes deafness in some patients.. "This is one of 31 human diseases that occur because of genetic ... "Our lab set out to determine if bone marrow-derived stem cell therapy might provide another treatment option." ... Sickle Cell Anemia: Effects of the disease and potential treatment Is it possible for enterovirus to be the next acute flaccid ...

https://www.emaxhealth.com/39/5725.html

Transient bone marrow oedema (TBMO) is an uncommon condition associated with joint and bone pain on activity. The most common ... An MRI scan was subsequently obtained of the hands also, which also showed bone marrow oedema. Axial bone mineral density was ... whereas bone oedema shows diffuse changes of intensity.1 In our patient marked bone marrow oedema was seen in both feet and ... Juvenile bone-marrow oedema of the acetabulum treated by iloprost. J Bone Joint Surg Br2002;84:1050-2. ...

https://ard.bmj.com/content/63/11/1528

Doubling the low amount of total body radiation delivered to patients undergoing bone marrow transplants with donor cells that ... Half-match bone marrow transplants wipe out sickle cell disease in selected patients. Sep 20, 2012 ... Blood diseases cured with bone marrow transplant. by Johns Hopkins University School of Medicine ... 16 aplastic anemia patients free of disease after bone marrow transplant and chemo. Feb 07, 2017 ...

https://medicalxpress.com/news/2019-03-blood-diseases-bone-marrow-transplant.html

Bone marrow-derived immune cells regulate vascular disease through a p27Kip1-dependent mechanism. Manfred Boehm, Michelle Olive ... we report that p27Kip1 plays a major role in cardiovascular disease through its effects on the proliferation of bone marrow- ... Host bone-marrow cells are a source of donor intimal smooth-muscle-like cells in murine aortic transplant arteriopathy. Nat. ... Bone marrow-derived (BM-derived) cells are increasingly recognized as key components of vascular regeneration (14-16). After ...

https://www.jci.org/articles/view/20176

Robin Roberts announced she has been diagnosed with a rare blood and bone marrow disease. INSIDE EDITION has the latest. ... Robin Roberts Announces She Has Rare Blood and Bone Marrow Disease. Entertainment 10:00 AM PDT, June 11, 2012 - Inside Edition ... Robin Roberts Announces She Has Rare Blood and Bone Marrow Disease. Entertainment ... It is a rare blood disorder that affects the bone marrow.". The disorder is sometimes called pre-leukemia. The Good Morning ...

https://www.insideedition.com/entertainment/4518-robin-roberts-announces-she-has-rare-blood-and-bone-marrow-disease

3D models of the bone marrow in health and disease: yesterday, today, and tomorrow - Volume 9 Issue 1 - Annamarija Raic, Toufik ... Here, 3D bone marrow models, their fabrication methods (including 3D bioprinting), and implementations recapturing bone marrow ... 52.Torisawa, Y.S., Spina, C.S., Mammoto, T., Mammoto, A., Weaver, J.C., Tat, T., Collins, J.J., and Ingber, D.E.: Bone marrow- ... 126.Zhou, X., Castro, N.J., Zhu, W., Cui, H., Aliabouzar, M., Sarkar, K., and Zhang, L.G.: Improved human bone marrow ...

https://www.cambridge.org/core/journals/mrs-communications/article/3d-models-of-the-bone-marrow-in-health-and-disease-yesterday-today-and-tomorrow/41695EDB449FE34A8473E8D2F589FC43

The Division of Bone Marrow Transplantation and Immune Deficiency at Cincinnati Children's is an international leader in delivering cutting-edge therapies for many diseases such as refractory, or hard-to-treat, cancers, rare genetic conditions affecting the immune system, hemoglobinopathies and bone marrow failure syndromes. (cincinnatichildrens.org)
Chronic graft-versus-host-disease (cGVHD) is a frequent and severe complication of allogeneic hematopoietic stem cell transplantation (AHSCT). (nature.com)
Twelve patients with metastatic breast carcinoma who had stable disease after standard-dose chemotherapy and six who had a partial response underwent allogeneic transplantation. (nature.com)
Now, treatment of a number of diseases is possible through stem cell transplantation. (medscape.com)
The purpose of this study is to determine whether bilateral orthotopic lung transplantation (BOLT) followed by cadaveric partially-matched hematopoietic stem cell transplantation (HSCT) is safe and effective for patients aged 5-45 years with primary immunodeficiency (PID) and end-stage lung disease. (clinicaltrials.gov)
The primary purpose of the study is to evaluate the safety and efficacy of performing bilateral orthotopic lung transplantation (BOLT) followed by cadaveric, partially HLA-matched CD3+/CD19+-depleted hematopoietic stem cell transplantation (HSCT) from the same donor for patients with primary immunodeficiency diseases (PID) and end-stage lung disease. (clinicaltrials.gov)
Prior to transplantation, the marrow will be negatively selected for CD3/CD19 using a CliniMACS® depletion device. (clinicaltrials.gov)
Use of a lower intensity bone marrow transplantation method showed promising results among 30 patients (16-65 years of age) with severe sickle cell disease, according to a study in the July 2 issue of JAMA . (eurekalert.org)
VANCOUVER, WASHINGTON (November 14, 2017) - Newly published research provides preclinical proof-of-concept for the ability of PRO 140, a humanized anti-CCR5 monoclonal antibody under development by CytoDyn Inc. (OTC.QB: CYDY), to effectively block the development of graft-versus-host disease (GvHD), a potentially lethal complication of bone marrow stem cell (BMSC) transplantation. (eurekalert.org)
The study, by Denis R. Burger, Ph.D., CytoDyn Chief Science Officer, and Daniel Lindner, M.D., Ph.D. of the Department of Translational Hematology and Oncology Research, The Cleveland Clinic, has been published online in the peer-reviewed journal, Biology of Blood and Marrow Transplantation . (eurekalert.org)
These latest findings add to an extensive and growing body of evidence supporting the safety and effectiveness of half-matched bone marrow transplants," says Richard Jones, M.D., director of the Johns Hopkins Kimmel Cancer Center bone marrow transplantation program. (medicalxpress.com)
CMV infection is also associated with indirect effects in transplant recipients, including adverse immunologic effects (graft versus host disease (GvHD) after bone marrow transplantation and graft rejection after solid organ transplantation), serious bacterial and fungal infections, and reduced overall survival rates. (medicalnewstoday.com)
The purpose of this study evaluate the effect of the method of administration of autologous bone marrow mononuclear cells for the duration of of functioning aorto-coronary bypass grafts in the surgical treatment of coronary heart disease, to assess the degree of effectiveness depending on the method of transplantation (intramyocardial, intracoronary). (clinicaltrials.gov)
Graft versus host disease (GvHD) remains a major complication after allogeneic hematopoietic stem cell transplantation and is the main cause of transplant-related mortality. (wiley.com)
Hematopoietic stem cell transplantation (HSCT) has become an accepted and widely used treatment option for defined malignant and nonmalignant diseases. (wiley.com)
Collaborative study of marrow transplantation for sickle cell disease: aspects specific for transplantation of hemoglobin disorders. (springer.com)
Bone marrow transplantation in thalassemia: the experience of Persaro. (springer.com)
Impact of bone marrow transplantation for symptomatic sickle cell disease: an interim report. (springer.com)
Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia. (springer.com)
The evolving role of blood and marrow transplantation for the treatment of autoimmune diseases. (springer.com)
A prototype drug already shown to hold promise for treating autoimmune disorders like lupus, arthritis and psoriasis halts established graft-versus-host disease in mouse models of bone marrow transplantation, research at the University of Michigan and the University of Florida shows. (cbslocal.com)
Bone marrow transplantation is a life-saving procedure used to treat diseases once thought incurable, including leukemia, aplastic anemia, Hodgkin's disease, multiple myeloma, immune deficiency disorders, and some solid tumors. (cbslocal.com)
During what's known as allogeneic bone marrow transplantation, healthy bone marrow stem cells from a donor are transfused into a patient, replacing marrow that is either not working properly or has been destroyed by chemotherapy or radiation. (cbslocal.com)
This condition, known as GVHD, is often life-threatening and greatly limits the use of allogeneic bone marrow transplantation. (cbslocal.com)
In the new work, a research team led by U-M faculty members Gary Glick and James Ferrara tested a compound called Bz-423 in several mouse models of bone marrow transplantation. (cbslocal.com)
The primary objectives of this study are to assess renal allograft tolerance (that is, the acceptance of the kidney without the need for anti-rejection therapy), assess anti-tumor response rates in multiple myeloma and AL amyloidosis, and assess complication rates for genetically (HLA) matched related donor combined bone marrow and kidney transplantation using a low dose total body irradiation based preparative regimen. (clinicaltrials.gov)
Renal failure is a major complication of multiple myeloma and AL amyloidosis for which the only known cure is allogeneic bone marrow transplantation. (clinicaltrials.gov)
Standard bone marrow transplantation is associated with prohibitive toxicities in patients with end stage renal disease, and is generally not considered an option for those patients. (clinicaltrials.gov)
A less toxic bone marrow transplantation protocol, utilizing low dose total body irradiation and anti-thymocyte globulin, combined with renal transplantation, could provide an opportunity for cure of the myeloma or amyloidosis and correction of end stage renal disease. (clinicaltrials.gov)
Treatments for MDS and AML involve bone marrow transplantation or intensive chemotherapy. (army.mil)
Apheresis of Family Members of Patients Undergoing Allogeneic Bone Marrow Transplantation. (knowcancer.com)
A treatment regimen with Gazyva (obinutuzumab) plus dexamethasone, high-dose cytarabine and cisplatin was well tolerated in patients with mantle cell lymphoma who were eligible for bone marrow transplantation, according to study results published in Lancet Haematology . (curetoday.com)
73% men) ages 18 to 66 years with newly diagnosed mantle cell lymphoma who were eligible for autologous stem cell transplantation, or bone marrow transplantation. (curetoday.com)
To evaluate prevalence of rebound thymic hyperplasia (RTH) after bone marrow transplantation (BMT) in paediatric patients with haemato-oncological diseases. (termedia.pl)
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. (nih.gov)
Mature donor T cells cause graft-versus-host disease (GVHD), but they are also the main mediators of the beneficial graft-versus-tumor (GVT) activity of allogeneic bone marrow transplantation. (nih.gov)
We have previously shown that donor-derived CD4+CD25+ regulatory T cells inhibit lethal GVHD after allogeneic bone marrow transplantation across major histocompatibility complex (MHC) class I and II barriers in mice. (nih.gov)
In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
[ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
These data reinforce the need for marked vigilance in ensuring proper screening and management of long-term survivors of bone marrow transplantation. (medscape.com)
Bone marrow transplantation in sickle cell anaemia. (bmj.com)
Therefore a bone marrow transplantation was performed in 12 patients staying in Belgium and planning to return to Africa. (bmj.com)
Twelve patients, aged between 11 months and 23 years (median 4 years), underwent a HLA identical bone marrow transplantation. (bmj.com)
A further patient suffered transient red cell hypoplasia and another underwent a second bone marrow transplantation from the same donor at day 62 because of graft rejection. (bmj.com)
The PREDICT (Precision Diagnostics in Inflammatory Bowel Disease, Cellular Therapy and Transplantation) trial is expected to first provide clinicians new information about why IBD arises in children, allowing them to tailor treatment plans to each patient. (seattlechildrens.org)
α4-1BB mAb increased the graft-vs-leukemia effect of a suboptimal number of donor splenocytes given later post bone marrow transplantation by bolstering allogeneic responses resulting in leukemia elimination. (jimmunol.org)
Modifying the ligation of 4-1BB represents a new approach to altering the graft-vs-host disease and graft-vs-leukemia effects of allogeneic T cells post bone marrow transplantation. (jimmunol.org)
BACKGROUND: Proper histomorphological interpretation of intestinal acute graft versus host disease (A-GVHD) associated with allogeneic bone marrow transplantation (BMT) is critical for clinical management. (biomedsearch.com)
Bone marrow transplantation (BMT) is an effective strategy to induce tolerance across xenogeneic barriers. (pubmedcentralcanada.ca)
Chronic graft-versus-host-disease (cGVHD) is the leading cause of later non-relapse mortality and morbidity after allo-hematopoietic stem cell transplantation (HCT). (renalandurologynews.com)
But this new scoring system will help identify patients that need a different approach, says Levine, who also is clinical director of the Pediatric Blood and Marrow Transplantation program at C.S. Mott Children's Hospital. (healthcanal.com)
PURPOSE: Randomized phase II/III trial to compare the effectiveness of treated bone marrow with that of untreated bone marrow in preventing graft-versus-host disease in patients with acute or chronic leukemia who are undergoing bone marrow transplantation. (bioportfolio.com)
Compare the efficacy of processed (cell depleted) vs unprocessed (conventional) unrelated bone marrow transplantation in reducing grade III/IV acute graft vs host disease (GVHD) in patients with acute or chronic leukemia or myelodysplastic syndromes. (bioportfolio.com)
Patients are randomized to one of two bone marrow transplantation arms. (bioportfolio.com)
Graft- versus -host disease (GVHD) remains a major cause of morbidity and mortality following bone marrow transplantation. (aacrjournals.org)
Clinical results following the in vitro T-lymphocyte depletion of donor bone marrow for the 8 histocompatible and 15 nonhistocompatible bone marrow transplantation are reported. (aacrjournals.org)
In the nonhistocompatible bone marrow transplantation, failure of engraftment occurred in 11 patients. (aacrjournals.org)
Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. (rupress.org)
The data provide no support for the view that chronic GVHD developing after bone marrow transplantation in man is the result of an attack by the progeny of the donor stem cells. (rupress.org)
6 5 Stem cell transplantation is the only curative treatment in autoimmune diseases, as the non-malignant B-lymphocytes underlying many of these diseases are often difficult to eradicate with non-myeloablative chemotherapy. (haematologica.org)
We report a case of a woman with celiac disease who underwent stem cell transplantation for acute leukemia. (haematologica.org)
Bone marrow transplantation corrects macrocytosis and haemolysis. (biologists.org)
We previously reported that bone marrow grafts from matched sibling donors resulted in best graft- versus -host disease-free, relapse-free survival at 1-year post allogeneic hematopoietic cell transplantation. (haematologica.org)
Disease relapse and graft- versus -host disease (GVHD) impact the length and quality of life after allogeneic hematopoietic cell transplantation (HCT). (haematologica.org)
Objective: To examine the feasibility, safety and efficacy of bone marrow transplantation in high-risk adult patients with chronic granulomatous disease (CGD) using a modified low-toxicity conditioning regimen. (aspergillus.org.uk)
Hematopoietic stem cell transplantation (HSCT) using an optimized conditioning regimen is essential for the long-term survival of patients with inherited bone marrow failure syndromes (IBMFS). (springermedizin.de)
Gluckman E, Wagner JE (2008) Hematopoietic stem cell transplantation in childhood inherited bone marrow failure syndrome. (springermedizin.de)
Peffault de Latour R, Peters C, Gibson B et al (2015) Recommendations on hematopoietic stem cell transplantation for inherited bone marrow failure syndromes. (springermedizin.de)
Bizzetto R, Bonfim C, Rocha V et al (2011) Outcomes after related and unrelated umbilical cord blood transplantation for hereditary bone marrow failure syndromes other than Fanconi anemia. (springermedizin.de)
Microencapsulated and nonmicroencapsulated rat bone marrow derived mesenchymal stromal cells were noted in the substantia nigra pars compacta up to 42 days after transplantation. (ovid.com)
Transplantation of nonmicroencapsulated rat bone marrow derived mesenchymal stromal cells improved urodynamic pressure by 42 days after treatment more markedly than microencapsulated cells. (ovid.com)
Background-Recent reports have shown a probable association between certain HLA antigens and acute graft versus host disease (GVHD) after allogeneic bone marrow transplantation (BMT). (sid.ir)
Methods-Medical records of 162 patients who had undergone allogeneic BMT from an HLA-identical sibling in the Hematology, Oncology and Bone Marrow Transplantation Center of Shariati Hospital in Tehran between 1991 and 1999, were studied and analyzed by univariate and multivariate analyses. (sid.ir)
Pulmonary complications have emerged as one of the major problem of allogeneic bone marrow transplantation (ITT). (springer.com)
Obliterative bronchiolitis: a distinct pathophysiologicai form of pulmonary involvement in bone marrow transplantation. (springer.com)
Airways obstruction associated with graft versus host disease after bone marrow transplantation. (springer.com)
Rodriguez-Roisin R., Roca J., Marín P., Grañena A., Agustí-Vidal A., Rozman C. (1985) Pulmonary Follow-Up in Patients with Bone Marrow Transplantation (BMT) and Graft-Versus-Host Disease (GVHD). (springer.com)
Autoimmune cytopenia has also been described in patients that have undergone allogeneic or autologous bone marrow transplantation. (elsevier.com)
We report a rare case of Evans syndrome in a patient 3 years after autologous bone marrow transplantation for recurrent Hodgkin's disease. (elsevier.com)
Bone marrow transplantation , 20 (12), 1099-1101. (elsevier.com)
Our findings revealed that transplantation therapy using BMSCs overexpressing bFGF significantly improved the symptoms of the repair effect compared to the BMSC transplantation group in a rat model of Chronic Obstructive Pulmonary Disease ( COPD ). (alliedacademies.org)
Allogeneic transplantation has resulted in disappearance of Crohn's disease for fifteen years. (crohnsforum.com)
A clinical trial known as ASTIC - Autologous Stem Cell Transplantation International Crohn's Disease - included 45 patients with positive results, though the findings were preliminary. (crohnsforum.com)

Graft-versus-Host disease (GVHD) often occurs after allogeneic bone marrow transplants (BMT). (nationwidechildrens.org)
In GVHD, the donor's bone marrow attacks the patient's organs and tissues, making them less able to function well. (nationwidechildrens.org)
GVHD can be a minor, short-term problem or a serious, life-threatening disease. (nationwidechildrens.org)
Acute GVHD most often occurs in the first 100 days after a bone marrow transplant. (nationwidechildrens.org)
[ 2 ] Because the same mechanism is involved in graft-versus-host disease (GVHD), the incidence of GVHD could be as high as 60% in these patients. (medscape.com)
The incidence of acute graft-versus-host disease (GVHD) is similar with the two methods. (medscape.com)
The number of patient who develop acute graft-versus-host disease (GVHD). (clinicaltrials.gov)
The number of patient who develop chronic graft-versus-host disease (GVHD). (clinicaltrials.gov)
This review focuses on the bone marrow as a target of GvHD, the factors that contribute to myelosuppression, and the possible therapeutic approaches. (wiley.com)
Besides infection, graft versus host disease (GvHD) remains the main cause of morbidity and mortality after allogeneic HSCT. (wiley.com)
Currently, allogeneic bone marrow transplant recipients are given drugs that suppress the immune system in order to lessen the effects of GVHD. (cbslocal.com)
The researchers turned their attention to GVHD because it's an important medical problem and also because in animal models, disease-causing cells can easily be distinguished from normal cells. (cbslocal.com)
Bz-423 provides a much higher level of selectivity for silencing disease-causing cells than is seen with the immunosuppressive drugs typically used for diseases like GVHD," Glick said. (cbslocal.com)
In the experiments described in the paper, Bz-423 arrested GVHD in mice by selectively killing disease-causing T cells, with no adverse effects on normal cells or bone marrow transplant success. (cbslocal.com)
Additionally, it is believed that standard therapy may be associated with a higher risk of a complication called graft versus host disease (GVHD) where the new donor cells attack the recipient's normal body. (centerwatch.com)
Recently, less intense chemotherapy and radiation regimens have been employed (these are called reduced intensity regimens) which cause less injury and GVHD to patients, and thus, have allowed older and less healthy patients to undergo bone marrow transplant. (centerwatch.com)
In an effort to find new strategies to personalize treatment for pediatric patients, Seattle Children's has opened the first clinical trial applying next-generation T-cell receptor (TCR) sequencing and single-cell gene expression analysis to better understand how the immune system drives both inflammatory bowel disease (IBD) in pediatric autoimmunity patients and graft-versus host disease (GVHD) in pediatric bone marrow transplant (BMT) patients. (seattlechildrens.org)
GVHD occurs when the T cells of newly transplanted bone marrow begin to attack a patient's tissues, including those of the skin, liver and intestine. (seattlechildrens.org)
Standard treatments aimed at suppressing or modulating the immune response are often ineffective in managing diseases like IBD and GVHD. (seattlechildrens.org)
PREDICT aims to bridge IBD and GVHD, shedding new light on the immunologic similarities they share and identifying the molecular causes of each patient's disease. (seattlechildrens.org)
Therefore, we analyzed three types of clinically relevant in vivo alloresponses: graft-vs-host disease (GVHD), allogeneic bone marrow (BM) graft rejection, and graft-vs-leukemia (GVL). (jimmunol.org)
Colon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patients. (biomedsearch.com)
2 However, all animals suffered from graft-vs-host disease (GVHD). (pubmedcentralcanada.ca)
CGVHD can occur following acute graft-versus-host-disease (aGVHD), can overlap with aGVHD, or occur without preceding acute GVHD (de novo cGVHD). (renalandurologynews.com)
ANN ARBOR, Mich. - A new test can guide treatment for patients with graft versus host disease (GVHD), an often life-threatening complication of bone marrow and stem cell transplants, according to research from the University of Michigan published in Lancet Haematology this month. (healthcanal.com)
Around half of patients who get a bone marrow transplant will develop GVHD, which can be lethal if it can't be controlled. (healthcanal.com)
The in vitro removal of the GVHD-causing T-lymphocytes from donor marrow is one approach which could control this complication. (aacrjournals.org)
Bone marrow from 23 consecutive donors was treated in vitro with CT-2 and complement, prior to infusion, as a potential means of controlling GVHD. (aacrjournals.org)
In two situations, transfer of normal unsensitized bone marrow cells into heavily irradiated H-2-identical allogeneic mice caused a high incidence of lethal chronic graft-versus-host disease (GVHD), i.e. mortality occuring between days of 20 and 80 postirradiation. (rupress.org)
Removing mature T cells from the marrow with anti-Thy 1.2 serum and complement before injection prevented GVHD. (rupress.org)
On the basis of adding purified T cells to T-cell-depleted marrow cells, it was concluded that contamination of the marrow with as few as 0.3% T cells was sufficient to cause a high incidence of lethal GVHD in certain situations. (rupress.org)
The results imply that mature T cells contaminating marrow inocula are probably the main cause of GVHD seen in the clinical situation. (rupress.org)
The incidence of grade II-III acute graft versus host disease (GvHD) and chronic GvHD was 29.2% and 16.7%, respectively. (springermedizin.de)

Bone marrow is the traditional source of stem cells for both autologous and homologous transplants. (medscape.com)
Doubling the low amount of total body radiation delivered to patients undergoing bone marrow transplants with donor cells that are only "half-matched" increased the rate of engraftment from only about 50 percent to nearly 100 percent, according to a new study by Johns Hopkins researchers. (medicalxpress.com)
Bone marrow transplants are not just for patients with a perfectly matched donor. (medicalxpress.com)
In the late 1980s, explain study leaders Javier Bolaños-Meade, M.D., associate professor of oncology at the Johns Hopkins Kimmel Cancer Center, and Brodsky, researchers discovered that bone marrow transplants could potentially cure sickle cell disease , a condition with few effective treatments and one that typically kills patients in their 40s. (medicalxpress.com)
Since finding a full match is difficult in this patient population-fewer than 15 percent have fully matched siblings free of the same genetic defect that causes sickle cell disease, and less than a quarter have full matches in unrelated registries-Johns Hopkins researchers developed a protocol, published in 2012, that allows patients to receive transplants from relatives who are only half-matched. (medicalxpress.com)
Seeking to increase the odds of engraftment for these half-matches, Bolaños-Meade and his colleagues tested a new protocol for bone marrow transplants in patients with severe sickle cell disease and beta thalassemia, two related blood disorders known as hemoglobinopathies that are caused by defects in the same beta-globin gene. (medicalxpress.com)
After their transplants, all received a dose of cyclophosphamide, a drug that has proved critical to avoiding a potentially deadly condition known as graft versus host disease that is particularly prevalent with half-matches. (medicalxpress.com)
We have performed more than 1,000 half-matched bone marrow transplants, and our clinical studies have proved so successful, with safety and toxicity comparable to matched transplants, that half-identical transplants must be made available to more patients as a curative option. (medicalxpress.com)
Emily Meier, MD, Director of the Sickle Cell Disease Program , discusses bone marrow transplants at Children's National and some of the complications of sickle cell disease. (childrensnational.org)
Patients with fatal blood cancers like leukemia often need bone marrow or stem cell transplants to survive. (healthcanal.com)
We will try to make bone marrow transplants to treat EB a normal procedure," Prof. Liem told Vietweek Tuesday. (thanhniennews.com)

Patients undergo total body irradiation on day 0, followed by allogeneic bone marrow transfusion. (knowcancer.com)
Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implication for cell therapy of bone. (springer.com)
Arm I: Patients receive allogeneic bone marrow that has been processed to produce a mononuclear cell preparation. (bioportfolio.com)
Arm II: Patients receive unprocessed allogeneic bone marrow. (bioportfolio.com)

A buccal swab can be used for human leukocyte antigen (HLA) typing of bone marrow donors. (medscape.com)
Buccal swabs are typically obtained at the time of bone marrow registry enrollment for all potential donors. (medscape.com)
Donors are screened for transmittable diseases such as HIV , hepatitis, West Nile virus , syphilis , and human T-lymphotropic virus (HTLV). (medscape.com)
However, certain donors with these diseases may still be considered for donation on a case-to-case basis. (medscape.com)
Until recently, it required bone marrow donors and recipients to fully match each other in a set of proteins known as human leukocyte antigens that are displayed on cells . (medicalxpress.com)
However, this treatment has only been used sparingly since then-until recently, it required bone marrow donors and recipients to fully match each other in a set of proteins known as human leukocyte antigens that are displayed on cells. (ptcommunity.com)
Despite the fact that the majority of bone marrow donors donate through peripheral collection, which is simply having their blood drawn, Joseph Adamson donated through bone marrow asperation, meaning it was taken directly from his bone. (oaklandpostonline.com)
Results MSCs isolated from patients with Crohn's disease showed similar morphology, phenotype and growth potential compared to MSCs from healthy donors. (bmj.com)
In adults, bone marrow from matched sibling donors (n=123) had best graft- versus -host disease-free, relapse-free survival at 1- and 2-years, compared with peripheral blood stem cell from matched sibling donors (n=540) or other graft/donor types. (haematologica.org)
In multivariate analysis, peripheral blood stem cells from matched sibling donors resulted in a 50% increased risk of events contributing to graft- versus -host disease-free, relapse-free survival at 1- and 2-years than bone marrow from matched sibling donors. (haematologica.org)

As a secondary aim after successful engraftment with donor bone marrow, there is realistic hope for tolerating planned withdrawal of immunosuppression achieving eventual freedom from all immunosuppressive drugs and attaining a tolerant state. (clinicaltrials.gov)
As in the previous protocol, all received doses of chemotherapy and total body irradiation to knock down their immune response to the donor bone marrow before transplant. (medicalxpress.com)
The new donor bone marrow must precisely match the genetic makeup of the patient's own marrow. (cbslocal.com)
Donor bone marrow engraftment leads to kidney graft tolerance in animal models. (clinicaltrials.gov)
Treatment of the donor bone marrow with lectins and erythrocyte-forming rosette depletion, anti-T-cell antisera or monoclonal antibodies are methods currently being tested to accomplish this. (aacrjournals.org)

This may be due to a defect in the stem cell producing them or due to an injury to the bone marrow environment. (news-medical.net)
Davies and her colleagues have developed disease-specific hematopoietic stem cell transplant approaches and new treatments that have improved outcomes for patients. (cincinnatichildrens.org)
Ruxolitinib effectively controls the symptoms but does not offer a cure, as the malignant stem cell clone is located in the bone marrow and is generally not attacked. (innovations-report.com)
Matthew M. Hsieh, M.D., of the National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Md., and colleagues explored a nonmyeloablative approach in a pilot group of 10 adults with severe sickle cell disease, using a simplified HSCT regimen (with stem cell donation from a immunologically matched sibling), that had few toxic effects, yet all patients continued taking immunosuppression medication. (eurekalert.org)
Professor Katayama comments: 'The only permanent cure for this disease is hematopoietic stem cell transplant, but this method is unsuitable for many elderly patients. (news-medical.net)
Our lab set out to determine if bone marrow-derived stem cell therapy might provide another treatment option. (emaxhealth.com)
The complex interaction between hematopoietic stem cells (HSCs) and their microenvironment in the human bone marrow ensures a life-long blood production by balancing stem cell maintenance and differentiation. (cambridge.org)
ViroPharma Incorporated (Nasdaq: VPHM) announced the publication of results of its previously described Phase 2 study showing that maribavir, when used as prophylaxis, reduced the rate of cytomegalovirus (CMV) reactivation and was well tolerated when compared to placebo in allogeneic stem cell , or bone marrow , transplant patients. (medicalnewstoday.com)
Approximately 60 percent of all at-risk allogeneic stem cell (bone marrow) transplant patients will show evidence of CMV infection in the first 100 days post transplant and despite treatment with currently available therapies approximately 10 percent of these patients will progress to develop CMV disease, which may manifest as deadly complications such as pneumonia or gastrointestinal disease. (medicalnewstoday.com)
Disease-associated impairment/dysfunction of stem cell populations is prominent in chronic metabolic and inflammatory diseases, such as type 2 diabetes mellitus (DM) where the multifunctional properties (viability, proliferation, paracrine secretion, multilineage differentiation) of bone marrow resident mesenchymal stem cells (MSCs) can be affected. (springer.com)
Lu L, Song H-F, Zhang W-G, Liu XQ, Zhu Q, Cheng XL et al (2012) Potential role of 20S proteasome in maintaining stem cell integrity of human bone marrow stromal cells in prolonged culture expansion. (springer.com)
Patients with acquired and inherited bone marrow failure syndromes (BMFS) have ineffective hematopoiesis due to impairments of the hematopoietic stem cell compartment. (aamds.org)
Vietnam has become only the second country in the world to successfully use stem cell transplant to treat Epidermolysis Bullosa (EB), an inherited connective tissue disease caused by problems with chemicals that cement the layers of skin together. (thanhniennews.com)
Acute graft-versus-host disease (aGVHD) is the most common and important complication of allogenic hematopoietic stem cell transplant (alloHCT). (neurologyadvisor.com)
With limited numbers of peripheral blood stem cell grafts in pediatric patients (n=12), graft- versus -host disease-free, relapse-free survival did not differ between bone marrow and peripheral blood stem cell graft from any donor. (haematologica.org)
Alternatively, novel graft- versus -host disease prophylaxis regimens are needed to substantially impact graft- versus -host disease-free, relapse-free survival with the use of peripheral blood stem cell. (haematologica.org)
Pulmonary complications of hematologic diseases like leukemia or after bone marrow or hematopoietic stem cell transplantations (HSCT) are common. (endocrinologyadvisor.com)
Kidney diseases that are unique to bone marrow transplant (aka Stem Cell Transplant or SCT) are frequently seen in cancer patients. (wikipedia.org)

These included bone marrow failure associated with neurological abnormalities (learning defects and developmental delay), and patients whose parents were first cousins. (healthcanal.com)

Graft- versus -host disease-free, relapse-free survival was defined as the absence of grade III-IV acute graft- versus -host disease, chronic graft- versus -host disease (requiring systemic therapy or extensive stage), relapse and death. (haematologica.org)
Possible association between obliterative bronchiolitis and chronic graft-versus-host disease. (springer.com)

Detailed data on each patient's drug exposures, duration and disease characteristics were collected and compared to autoimmune patients without bone marrow disorders of myelodysplastic syndromes or acute myeloid leukemia. (eurekalert.org)
The cells are obtained by inserting a needle into the patient's hip bone. (blindness.org)
Symptoms of Alport syndrome, the second most common genetic cause of kidney failure, usually appear in children, affecting the kidneys' filtration system and typically leading to end-stage renal disease in the patient's teens, 20s or 30s. (emaxhealth.com)
Prior to the BMT, a patient must undergo chemotherapy, which prepares the body to accept the new cells by "making space" in the bone marrow, and also suppresses the patient's immune system to prevent rejection of the donor cells. (chop.edu)
If the donor's bone marrow is not perfectly matched, as is often the case, it can perceive the patient's body as foreign material to be attacked and destroyed. (cbslocal.com)
But one of the most common and serious side effects that patients face is graft vs. host disease: when a patient's new immune system from the transplant (the graft) attacks the patient's healthy tissue (the host). (healthcanal.com)
In both situations, however, HCT also has immunotherapeutic effects, which may provide important signals to eradicate the patient's disease. (cancertherapyadvisor.com)
First, is the patient and the patient's disease a candidate for autologous or allogeneic HCT? (cancertherapyadvisor.com)

MDS syndromes are classified by how the cells in the bone marrow and blood smear look under the microscope. (news-medical.net)
Leukemia, aplastic anemia and myelodysplastic syndromes (MDS) are three types of bone marrow disorders that affect the production of blood cells and the bone marrow. (livestrong.com)
Myeloid neoplasms include a spectrum of potentially life-threatening bone marrow disorders, such as myelodysplastic syndromes and acute myeloid leukemia. (eurekalert.org)
Further, the number of patients with autoimmune disease developing myelodysplastic syndromes or acute myeloid leukemia is still low overall, and no prediction for individual patients can be concluded from the study. (eurekalert.org)
BMT is used to treat a range of pediatric conditions from leukemia to inherited bone marrow failure syndromes, congenital metabolic disorders and other metabolic diseases. (seattlechildrens.org)
2 1 Consequently, it is increasingly acceptable to apply it to non-malignant disorders such as congenital or inherited immunodeficiency syndromes, hemoglobinopathies 4 3 and autoimmune diseases. (haematologica.org)
Chung NG, Kim M (2014) Current insights into inherited bone marrow failure syndromes. (springermedizin.de)
Alter BP (2007) Diagnosis, genetics, and management of inherited bone marrow failure syndromes. (springermedizin.de)
Tsangaris E, Klaassen R, Fernandez CV et al (2011) Genetic analysis of inherited bone marrow failure syndromes from one prospective, comprehensive and population-based cohort and identification of novel mutations. (springermedizin.de)

Polymeri A, Giannobile WV, Kaigler D (2016) Bone marrow stromal stem cells in tissue engineering and regenerative medicine. (springer.com)
Hurler disease bone marrow stromal cells exhibit altered ability to support osteoclast formation. (sigmaaldrich.com)
IDUA-mutated BM stromal cells (BMSC) derived from MPS IH patients exhibited decreased IDUA activity, consistent with the disease genotype. (sigmaaldrich.com)
Therefore BM-MSCs are also called bone marrow stromal cells . (omicsonline.org)
We sought to prolong the effect by injecting allogeneic rat bone marrow mesenchymal stromal cells before and after microencapsulation into the substantia nigra pars compacta. (ovid.com)
Injection was performed in the ipsilateral substantia nigra pars compacta using vehicle alone or vehicle with nonmicroencapsulated or microencapsulated rat bone marrow derived mesenchymal stromal cells. (ovid.com)
Recently, cell therapy has emerged as a promising treatment regime for various autoimmune diseases including MS. Mesenchymal stem/stromal cells (MSC), plastic adherent fibroblastic-like cells, have emerged as the promising cell therapy for the treatment of MS. In pre-clinical studies, MSC ameliorate disease in experimental autoimmune encephalomyelitis (EAE) with associated decreased in lymphocyte infiltration and demyelination in the CNS. (figshare.com)

A bone marrow biopsy of the iliac crest, including immunophenotyping, was negative for malignancy. (frontiersin.org)
A first biopsy of a thoracic vertebral body was performed showing normal marrow with a focus of fibrosis with a slight increase in polytypic plasma cells, eosinophils and mast cells with a normal morphology. (frontiersin.org)
Prof. Liem said Anh's skin biopsy showed the presence of type VII collagen, indicating he no longer has the disease. (thanhniennews.com)
Her past medical history was remarkable for celiac disease confirmed by endoscopic biopsy following a two-week dietary gluten challenge (serology for tissue transglutaminase/anti-gliadin antibodies was not performed). (haematologica.org)

Percentage of functioning grafts in patients with implantation of autologous bone marrow mononuclear cells. (clinicaltrials.gov)
FOCUS is a CCTRN-designed randomized, phase II, placebo-controlled clinical trial that will assess the effect of autologous bone marrow mononuclear cells delivered transendocardially to patients with left ventricular (LV) dysfunction and symptomatic heart failure or angina. (nih.gov)
The designed clinical trial will provide a sound assessment of the effect of autologous bone marrow mononuclear cells in improving blood flow and contractile function of the heart. (nih.gov)

Irradiated recipients of T-cell-depleted marrow cells remained in good health for prolonged periods. (rupress.org)
However, pediatric patients comprised the majority of bone marrow graft recipients in that study. (haematologica.org)
Rapidly progressive air-flow obstruction in marrow transplant recipients. (springer.com)

The diseases and disorders of the bone marrow include Leukemia, Myelodysplastic Syndrome, Myeloproliferative disorders and so forth. (news-medical.net)
Similar associations were already documented in case reports and case series, but have never been evaluated in a broad spectrum of autoimmune diseases in that many patients and in context of individual medications," says Raoul Tibes, M.D., Ph.D., senior author of the study and former director of the Acute and Chronic Leukemia Program at Mayo Clinic's Arizona campus. (eurekalert.org)
In about one third of patients, the disease transforms into an acute form of leukemia. (insideedition.com)
Dr. Abdel-Wahab's laboratory expressed a spliceosomal gene mutation in the Srsf2 gene, a mutation common in MDS and AML patients, in the bone marrow cells of a leukemia mouse model. (army.mil)
The mice expressing both mutant and wildtype Srsf2 rapidly developed fatal bone marrow failure and eventually developed leukemia. (army.mil)
This is likely due to the decreased survival of leukemia-promoting bone marrow cells expressing mutant Srsf2 in the absence of wildtype Srsf2 expression. (army.mil)
Detection of minimal or measurable residual disease (MRD) is an important prognostic biomarker for refining risk assessment and predicting relapse in acute myeloid leukemia (AML). (jove.com)
Her family history was notable for leukemia in her maternal grandfather, celiac disease in a paternal grandmother, and breast and bone cancer in two maternal aunts. (haematologica.org)
Past trials that included patients with Crohn's disease and leukemia have been successful for curing both Crohn's disease and leukemia. (crohnsforum.com)
Some malignancies that have spread to involve the bone marrow, such as leukemia or advanced Hodgkin's disease, also cause lymphocytopenia. (wikipedia.org)

Biol Blood Marrow Transplant . (springer.com)

As of October 25, 2013, 29 patients were alive with a median follow-up of 3.4 years, and 26 patients (87 percent) had long-term stable donor engraftment without acute or chronic graft-vs-host disease. (eurekalert.org)
All of those with successful engraftment had either extreme reduction or no symptoms of their disease-the sickle cell disease patients no longer had the pain crises that are hallmarks of their condition. (medicalxpress.com)
In addition, successful marrow engraftment may be expected to lead to a state of tolerance. (clinicaltrials.gov)
Onset may be later, following engraftment with marrow or umbilical cord graft sources. (neurologyadvisor.com)

Researchers analyzed more than 40,000 patient cases with 27 common autoimmune diseases, such as Lupus, rheumatoid arthritis, among others, that were seen over a decade at Mayo Clinic. (eurekalert.org)
Many different autoimmune diseases were analyzed, which can each affect the results. (eurekalert.org)
Recent studies showed that BM-MSCs could be used in the clinical treatment of autoimmune diseases, degenerative diseases and hypoxic ischemic brain damage [ 2 , 3 ]. (omicsonline.org)
These findings suggest that the improved isolation method developed in this study can firstly, be adopted by other researchers to isolate a well-characterised MSC from multiple mouse strains and secondly, the method can be modified, for example changing 5-FU treatment from in vivo to in vitro, to isolate a similar population of highly immunosuppressive human MSC for exploitation to remit autoimmune diseases. (figshare.com)

The study's lead author, John Levine, M.D., of the University of Michigan's Blood and Marrow Transplant Program and his colleagues studied almost 800 patients from the US and Germany to develop and validate a new scoring system. (healthcanal.com)

Early indications also show that the disorders of the gut could potentially be treated through the bone marrow, says Pam Fraker, Michigan State University professor of biochemistry and molecular biology. (futurity.org)
People who have anemia due to bone marrow disorders may bleed easily and more profusely than others. (livestrong.com)
Bone marrow disorders can lead to swelling of the internal organs in some people. (livestrong.com)
Males with blood disorders that lead to bone marrow abnormalities may experience a swelling of the testicles. (livestrong.com)
Bone marrow failure is a term used for a group of life threatening disorders associated with an inability of the bone marrow to make an adequate number of mature blood cells. (healthcanal.com)
HSCT is also considered for treatment of a variety of non-malignant disorders characterized by dysfunctional marrow function or autoimmunity, which are major causes of treatment-related death and morbidity. (endocrinologyadvisor.com)
HCT may serve as a rescue procedure in patients with malignant disorders treated with high-dose cytotoxic regimens or as replacement therapy in patients with missing, aberrant, or defective lymphohematopoietic cells, including marrow failure and autoimmune disorders. (cancertherapyadvisor.com)

According to the Aplastic Anemia and MDS International Foundation, a person with bone marrow disease may experience frequent infection and, as a result, swollen glands. (livestrong.com)
A bone marrow test at this hospital showed that he was suffering from Severe Aplastic Anemia, a rare bone marrow disease in which the blood cells are not formed. (milaap.org)

The development of nonmyeloablative conditioning regimens (use of lower doses of chemotherapy or radiation to prepare the bone marrow to receive new cells) may facilitate safer application of allogeneic HSCT to eligible adults, according to background information in the article. (eurekalert.org)
The LyMa-101 trial achieved its primary endpoint and showed the potential activity of obinutuzumab plus [dexamethasone, high-dose cytarabine and cisplatin] as induction chemotherapy , with bone marrow minimal residual disease negativity potentially predicting long-term disease control," the study authors wrote. (curetoday.com)
Traditionally, very strong cancer treatment drugs (chemotherapy) and radiation are used to prepare a subject's body for bone marrow transplant. (centerwatch.com)
The most common form of kidney disease in cancer patients is acute kidney injury (AKI) which can usually be due to volume depletion from vomiting and diarrhea that occur following chemotherapy or occasionally due to kidney toxicities of chemotherapeutic agents. (wikipedia.org)
Chronic Kidney disease after chemotherapy induced AKI 17. (wikipedia.org)

Patients with bone involvement were eligible if they had stable disease (SD) that showed clinical improvement. (nature.com)
A number of clinical trials have proved the superiority of this method over collection from the bone marrow. (medscape.com)
The researchers emphasize that, while the results of the study are intriguing, they should not change or replace the clinical judgments, monitoring and current standard treatments at this stage for patients with an autoimmune disease. (eurekalert.org)
April 11, 2013 - Researchers from the University of California, Davis (UC Davis), have launched a Phase I clinical trial of CD34+ bone marrow stem cells (BMSC) for people with retinal conditions that cause vision loss from ischemia, or loss of blood flow, and cell degeneration. (blindness.org)
Dr. Park became interested in using CD34+ BMSC for retinal conditions because they have shown promising results in clinical trials for ischemic cardiac disease. (blindness.org)
While this dose-ranging study evaluated the safety and the ability of maribavir to prevent viral reactivation in bone marrow transplant patients, we are particularly encouraged by the possibility that maribavir may help reduce the rate of CMV disease and associated morbidity, something we are investigating in our current Phase 3 study," said Stephen Villano, M.D., vice president, clinical research and development at ViroPharma. (medicalnewstoday.com)
A characteristic skeletal phenotype is one of the many clinical manifestations in Hurler disease. (sigmaaldrich.com)
Dr. Mamula, together with clinical immunologists Kathleen Sullivan, MD , Chief of the Division of Allergy and Immunology and Jennifer Heimall, MD , Co-founder of the Joint Bone Marrow Transplant-Immunology Clinic, explained the diagnosis to Luke's parents. (chop.edu)
Patients were recruited from all over the world to join an international bone marrow failure registry and researchers used new DNA sequencing technologies to study cases of bone marrow failure with similar clinical features. (healthcanal.com)
In addition to clinical work, she is highly dedicated to medical education and serves as the Director of the Infectious Diseases Fellowship Program. (utah.edu)
After thoughtful consideration of both statistical and clinical principles, we will recruit 87 patients (58 cell treated and 29 placebo) to receive either bone marrow-derived stem cells or placebo. (nih.gov)
The aim of this clinical trial is to investigate the efficacy (by monitoring the wound size reduction of Peripheral Arterial Occlusive Disease-related clinically relevant ulcers) and safet. (bioportfolio.com)
Research efforts have been made all over the world to improve understanding of the pathogenesis of these diseases and their clinical implications. (aamds.org)
Little is known about the character and clinical significance of disseminated tumor cells (DTCs) that have reached the bone marrow (BM) niche, and prior studies has relied on epithelial markers. (aacrjournals.org)
No predictive correlation could be found between the in vitro analysis of marrow following CT-2 treatment and clinical outcome. (aacrjournals.org)
Bone Marrow Mesenchymal Stem Cells (BMSCs) are primitive cells that can differentiate into many types of tissue cells for clinical use. (alliedacademies.org)
Fred Hutchinson Cancer Research investigators are currently enrolling patients in a clinical trial that could potentially lead to a cure for moderate to severe Crohn's disease that has failed other therapies including surgery. (crohnsforum.com)

However, osteoporosis is a rare finding in bone biopsies. (bmj.com)
We have evaluated the usefulness of bilateral rather than unilateral posterior iliac spine trephine biopsies in searching for lymphoma and other neoplastic diseases in the bone marrow. (annals.org)
We conclude that bilateral trephine bone marrow biopsies should be routinely performed when searching for tumor in the bone marrow. (annals.org)
BRUNNING RD, BLOOMFIELD CD, McKENNA RW, PETERSON L. Bilateral Trephine Bone Marrow Biopsies in Lymphoma and Other Neoplastic Diseases. (annals.org)
The diagnostic significance of tumor infiltrates topography and basicrules of the differential diagnoses of malignant lymphomas in the bone marrow biopsies arediscussed. (prolekare.cz)

Briquet A, Dubois S, Bekaert S, Dolhet M, Beguin Y, Gothot A (2010) Prolonged ex vivo culture of human bone marrow mesenchymal stem cells influences their supportive activity toward NOD/SCID-repopulating cells and committed progenitor cells of B lymphoid and myeloid lineages. (springer.com)

MPNs are a group of rare, malignant diseases of the bone marrow involving the production of an excess of red blood cells, white blood cells and/or platelets. (innovations-report.com)
This so-called HSC niche can be disturbed by malignant diseases. (cambridge.org)
While not all patients have a matched sibling donor, graft- versus -host disease-free, relapse-free survival may be improved by the preferential use of bone marrow for adults with malignant diseases. (haematologica.org)

Bone marrow disease occurs when there is some kind of abnormality or interference with the production of blood cells. (livestrong.com)
This condition can make it hard to control other diseases, and bone hardening (osteosclerosis) also occurs. (news-medical.net)
Myelodysplastic syndrome (MDS), also referred to as a "bone marrow failure disease" is most common in adults over the age of 65 and occurs when blood-forming cells in the bone marrow develop abnormally. (army.mil)
Moreover, inter-compartment migration between lymph nodes and bone marrow occurs in both directions. (haematologica.org)
The CATS trial (Crohn s Allogeneic Transplant Study) uses bone marrow transplant to help quell inflammation that occurs in only half of patients with moderate to severe Crohn's disease, making other treatment options vital. (crohnsforum.com)

Patients are stratified according to degree of HLA matching and disease (chronic vs acute). (bioportfolio.com)
MS patients generally have poor quality of life with patients suffering from recurrent acute neurological episodes with persistent symptoms or progressive development of the disease. (figshare.com)

The spleen, greatly enlarged by the disease, shrinks back to its normal size and the progression of the disease is delayed. (innovations-report.com)
Of these patients who were minimal residual disease positive, 12 patients tested positive in bone marrow, two patients had disease progression and four patients did not undergo minimal residual disease assessment. (curetoday.com)
Those patients transplanted in the early stages of the disease (less than 5 years) showed more improvement and no further disease progression than the later stages (11-15 years). (hindawi.com)
Chronic brain inflammation plays a critical role in the development and progression of Parkinson's disease. (michaeljfox.org)
Our hypothesis is that m ultiple intravenous infusions of mesenchymal stem cells from the bone marrow of a healthy donor will significantly slow the progression of Parkinson's disease when compared to placebo over a year. (michaeljfox.org)
The team expects this trial intends to provide evidence on the safety, effectiveness, and mechanism of action of multiple infusions of mesenchymal stem cells as a treatment to change the progression of Parkinson's disease. (michaeljfox.org)
To analyze the dissemination of lymphoma cells, and the role of the bone marrow for disease progression, we simultaneously analyzed the somatic hypermutation patterns of lymph node and bone marrow specimens of three patients at onset and relapse. (haematologica.org)
To date, there is no cure for MS, with management of the disease dependent on immunomodulatory interventions to minimize disease relapses and retard disease progression. (figshare.com)

MPNs are caused by genetic changes (mutations) of the hematopoietic cells in the bone marrow that are acquired spontaneously, due to certain genetic predispositions or as a result of environmental influences. (innovations-report.com)
This is one of 31 human diseases that occur because of genetic defects in the body's extracellular matrix and basement membrane proteins," explains the study's senior author Raghu Kalluri, PhD, chief of the division of matrix biology at BIDMC and associate professor of medicine at Harvard Medical School. (emaxhealth.com)
The causes of idiopathic Parkinson-disease (IPD) are believed to be a combination of genetic and environmental factors. (hindawi.com)
Now we know this research technique works, we plan to carry out further studies to shed more light on the genetic basis of many other cases of bone marrow failure. (healthcanal.com)

History of any immunosuppressive disease. (knowcancer.com)
The goal of treatment is to ensure there is no bone marrow rejection by using immunosuppressive drugs immediately after the transplant. (crohnsforum.com)

Dr. Park's study is enrolling people with retinal degenerative diseases, such as retinitis pigmentosa (RP), Stargardt disease and dry age-related macular degeneration (AMD). (blindness.org)

Duration of ischemic heart disease. (clinicaltrials.gov)
Among the CVD, ischemic heart disease (IHD) and non-ischemic valvular heart disease (VHD) are very frequent in older age. (biomedcentral.com)

There were no adverse events related to marrow aspiration or injection, and this study provides evidence of safety and feasibility of intradiscal BMC therapy. (springer.com)
Patients and intervention 10 adult patients with refractory Crohn's disease (eight females and two males) underwent bone marrow aspiration under local anaesthesia. (bmj.com)

Those considered minimal residual disease-positive underwent a post-maintenance phase of on-demand Gazyva for patients. (curetoday.com)

The bone marrow is a soft spongy tissue within the bones. (news-medical.net)
Bone marrow is a soft spongy material that is located inside of the bones. (livestrong.com)

The medical team recommended a bone marrow transplant to treat Luke's CGD by replacing the cells that develop into immune cells with new, healthy cells that would allow him to have effective infection-fighting neutrophils. (chop.edu)

Importantly, immunomodulatory capacity was intact, as Crohn's disease MSCs significantly reduced peripheral blood mononuclear cell proliferation in vitro. (bmj.com)

One goal in our study is to decrease the duration you will need to be on immunosuppressant drugs following your kidney transplant as the bone marrow transplant will provide you with the donor's immune system which should not attack the donor kidney. (centerwatch.com)

MDS is a group of diseases where there is abnormal bone marrow cell production. (news-medical.net)

Anatomy12

Organisms3

Diseases16

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes11

Technology, Industry, Agriculture1

Longevity, stress response, and cancer in aging telomerase-deficient mice. (1/551)

Phase I study of 90Y-labeled B72.3 intraperitoneal administration in patients with ovarian cancer: effect of dose and EDTA coadministration on pharmacokinetics and toxicity. (2/551)

Double-blind randomized study on the myeloprotective effect of melatonin in combination with carboplatin and etoposide in advanced lung cancer. (3/551)

Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals progression of erosions despite clinical improvement. (4/551)

Hematopoietic damage prior to PBSCT and its influence on hematopoietic recovery. (5/551)

First-line high-dose sequential chemotherapy with rG-CSF and repeated blood stem cell transplantation in untreated inflammatory breast cancer: toxicity and response (PEGASE 02 trial). (6/551)

Ticlopidine and clopidogrel. (7/551)

Measurement of vitamin B12-binding proteins of plasma. II. Interpretation of patterns in disease. (8/551)

Bone Marrow Neoplasms

Bone Marrow Diseases

Bone Marrow

Bone Marrow Cells

Neuroblastoma

Bone Marrow Transplantation

Bone and Bones

Bone Remodeling

Bone Marrow Examination

Hematopoietic Stem Cells

Bone Density

Bone Resorption

Bone Marrow Purging

Hematopoiesis

Bone Neoplasms

Transplantation, Homologous

Bone Development

Mice, Inbred C57BL

Bone Diseases

Colony-Forming Units Assay

Cell Differentiation

Bone Regeneration

Cells, Cultured

Whole-Body Irradiation

Transplantation, Autologous

Radiation Chimera

Stromal Cells

Graft vs Host Disease

Anemia, Aplastic

Osteogenesis

Flow Cytometry

Leukemia

Bone Matrix

Bone Transplantation

Antigens, CD34

Granulocytes

Spleen

Osteoblasts

Osteoclasts

Hematopoietic Stem Cell Transplantation

Transplantation Chimera

Multiple Myeloma

Pancytopenia

Leukemia, Myeloid, Acute

Cell Separation

Time Factors

Bone Substitutes

Bone Diseases, Metabolic

Megakaryocytes

Graft vs Host Reaction

Autoimmune Diseases

Myelodysplastic Syndromes

Azathioprine

Myelodysplastic-Myeloproliferative Diseases

Longevity, stress response, and cancer in aging telomerase-deficient mice. (1/551)

Phase I study of 90Y-labeled B72.3 intraperitoneal administration in patients with ovarian cancer: effect of dose and EDTA coadministration on pharmacokinetics and toxicity. (2/551)

Double-blind randomized study on the myeloprotective effect of melatonin in combination with carboplatin and etoposide in advanced lung cancer. (3/551)

Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals progression of erosions despite clinical improvement. (4/551)

Hematopoietic damage prior to PBSCT and its influence on hematopoietic recovery. (5/551)

First-line high-dose sequential chemotherapy with rG-CSF and repeated blood stem cell transplantation in untreated inflammatory breast cancer: toxicity and response (PEGASE 02 trial). (6/551)

Ticlopidine and clopidogrel. (7/551)

Measurement of vitamin B12-binding proteins of plasma. II. Interpretation of patterns in disease. (8/551)

Cancer in Inherited Bone Marrow Failure Syndromes - Full Text View - ClinicalTrials.gov

Cancer in Inherited Bone Marrow Failure Syndromes - Full Text View - ClinicalTrials.gov

Old and new tools in the clinical diagnosis of inherited bone marrow failure syndromes | Hematology | American Society of...

Bone Marrow Failure Research Program, Congressionally Directed Medical Research Programs

Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal...

Bone marrow suppression - Wikipedia

MRI-detected subchondral bone marrow signal alterations of the knee joint: terminology, imaging appearance, relevance and...

Mayo Clinic: Association between autoimmune disease and bone marrow disorders | EurekAlert! Science News

JCI Insight - Cellular and molecular architecture of hematopoietic stem cells and progenitors in genetic models of bone marrow...

Shilpa Hattangadi, MD > Yale Cancer Center | Yale School of...

Kurre Laboratory | Comprehensive Bone Marrow Failure Center

Transient bone marrow oedema in a child | Annals of the Rheumatic Diseases

Identification of vitamin D and other bone metabolism parameters as risk factors for primary bone marrow oedema syndrome | BMC...

Bone marrow lesions can predict joint disease - Canindia News

Bone marrow lesion in OA knee - Stem Cell Joints India

Bone Marrow Failure and MDS Program - Dana-Farber/Boston Childrens Cancer and Blood Disorders Center

Bone Marrow Suppression During Cancer Treatment in Children

Bone Marrow Suppression During Cancer Treatment in Children