Bone Marrow Cells
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Bone Marrow Transplantation
Bone and Bones
Colony-Forming Units Assay
Hematopoiesis
Bone Remodeling
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Bone Marrow Neoplasms
Cell Differentiation
Radiation Chimera
Cells, Cultured
Bone Density
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Granulocytes
Bone Marrow Purging
Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.
Transplantation, Homologous
Whole-Body Irradiation
Antigens, CD34
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Osteoclasts
Transplantation, Autologous
Colony-Stimulating Factors
Glycoproteins found in a subfraction of normal mammalian plasma and urine. They stimulate the proliferation of bone marrow cells in agar cultures and the formation of colonies of granulocytes and/or macrophages. The factors include INTERLEUKIN-3; (IL-3); GRANULOCYTE COLONY-STIMULATING FACTOR; (G-CSF); MACROPHAGE COLONY-STIMULATING FACTOR; (M-CSF); and GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; (GM-CSF).
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Bone Development
Stromal Cells
Cell Division
Transplantation Chimera
Interleukin-3
Hematopoietic Stem Cell Transplantation
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Erythropoiesis
The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.
Anemia, Aplastic
Thymus Gland
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Graft vs Host Disease
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Leukemia, Myeloid, Acute
Bone Regeneration
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Osteoblasts
Granulocyte Colony-Stimulating Factor
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Cell Lineage
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Stem Cells
Mice, Transgenic
Stem Cell Factor
Retroviridae
Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).
Leukemia, Myeloid
Granulocyte-Macrophage Colony-Stimulating Factor
An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
Myelodysplastic Syndromes
Cell Count
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Graft Survival
Antigens, CD
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Multiple Myeloma
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Clone Cells
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Immunophenotyping
B-Lymphocytes
Leukocyte Count
Proto-Oncogene Proteins c-kit
A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
Bone Matrix
Blood Cell Count
Pancytopenia
Erythroid Precursor Cells
The cells in the erythroid series derived from MYELOID PROGENITOR CELLS or from the bi-potential MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS which eventually give rise to mature RED BLOOD CELLS. The erythroid progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E); BFU-E differentiate into CFU-E on stimulation by ERYTHROPOIETIN, and then further differentiate into ERYTHROBLASTS when stimulated by other factors.
Antigens, Surface
Antigens, Ly
Transplantation, Isogeneic
Hematopoietic Cell Growth Factors
These growth factors comprise a family of hematopoietic regulators with biological specificities defined by their ability to support proliferation and differentiation of blood cells of different lineages. ERYTHROPOIETIN and the COLONY-STIMULATING FACTORS belong to this family. Some of these factors have been studied and used in the treatment of chemotherapy-induced neutropenia, myelodysplastic syndromes, and bone marrow failure syndromes.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.
Lymphocytes
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Cyclophosphamide
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
RANK Ligand
Disease Models, Animal
Macrophage Colony-Stimulating Factor
A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).
Antigens, Thy-1
Myeloid Progenitor Cells
Erythropoietin
Cell Survival
Leukocytes
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Mesenchymal Stromal Cells
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Antigens, CD45
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Myelopoiesis
Formation of MYELOID CELLS from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via MYELOID STEM CELLS. Myelopoiesis generally refers to the production of leukocytes in blood, such as MONOCYTES and GRANULOCYTES. This process also produces precursor cells for MACROPHAGE and DENDRITIC CELLS found in the lymphoid tissue.
Preleukemia
Busulfan
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Coculture Techniques
Thrombopoietin
Cell Movement
Gene Expression
Leukemia, Experimental
Erythrocytes
Bone Substitutes
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Phenotype
Transplantation Conditioning
Genetic Vectors
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
Erythroblasts
Green Fluorescent Proteins
Chemokine CXCL12
Tibia
Myeloproliferative Disorders
Immunohistochemistry
Leukopoiesis
The process of generating white blood cells (LEUKOCYTES) from the pluripotent HEMATOPOIETIC STEM CELLS of the BONE MARROW. There are two significant pathways to generate various types of leukocytes: MYELOPOIESIS, in which leukocytes in the blood are derived from MYELOID STEM CELLS, and LYMPHOPOIESIS, in which leukocytes of the lymphatic system (LYMPHOCYTES) are generated from lymphoid stem cells.
Mice, SCID
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Reverse Transcriptase Polymerase Chain Reaction
Tissue Donors
Hematopoietic Stem Cell Mobilization
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Radiation-Protective Agents
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Hematopoiesis, Extramedullary
Lymphopoiesis
Formation of LYMPHOCYTES and PLASMA CELLS from the lymphoid stem cells which develop from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW. These lymphoid stem cells differentiate into T-LYMPHOCYTES; B-LYMPHOCYTES; PLASMA CELLS; or NK-cells (KILLER CELLS, NATURAL) depending on the organ or tissues (LYMPHOID TISSUE) to which they migrate.
Chromosome Aberrations
Graft vs Host Reaction
Alkaline Phosphatase
Lymphocyte Depletion
Hematopoietic System
Antigens, Differentiation
Transduction, Genetic
Myeloid Cells
Mesenchymal Stem Cell Transplantation
Histocompatibility
Stem Cell Transplantation
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Gene Expression Regulation
Bone Morphogenetic Proteins
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
Plasma Cells
Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)
Interleukin-11
A lymphohematopoietic cytokine that plays a role in regulating the proliferation of ERYTHROID PRECURSOR CELLS. It induces maturation of MEGAKARYOCYTES which results in increased production of BLOOD PLATELETS. Interleukin-11 was also initially described as an inhibitor of ADIPOGENESIS of cultured preadipocytes.
Bone Morphogenetic Protein 2
Micronucleus Tests
Growth Substances
Treatment Outcome
Severe Combined Immunodeficiency
Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).
Base Sequence
Monocytes
Primary Myelofibrosis
Cell Transplantation
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Neovascularization, Physiologic
Leukemia, Lymphoid
Acid Phosphatase
Dose-Response Relationship, Drug
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Calcification, Physiologic
Interleukin-6
Histocompatibility Testing
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Lymphocyte Transfusion
Liver
Skin Transplantation
Osteocalcin
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Immune Tolerance
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Transplantation Immunology
Immunosuppression
Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.
Osteoporosis
Radiation Effects
Neutrophils
Radiation Injuries, Experimental
Killer Cells, Natural
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Lymphoid Tissue
Osteocytes
Benzene
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
Cytarabine
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
Culture Media, Conditioned
Deoxyuridine
Combined Modality Therapy
Tumor Cells, Cultured
Receptor Activator of Nuclear Factor-kappa B
A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Thymic selection by a single MHC/peptide ligand: autoreactive T cells are low-affinity cells. (1/12182)
In H2-M- mice, the presence of a single peptide, CLIP, bound to MHC class II molecules generates a diverse repertoire of CD4+ cells. In these mice, typical self-peptides are not bound to class II molecules, with the result that a very high proportion of H2-M- CD4+ cells are responsive to the various peptides displayed on normal MHC-compatible APC. We show here, however, that such "self" reactivity is controlled by low-affinity CD4+ cells. These cells give spectacularly high proliferative responses but are virtually unreactive in certain other assays, e.g., skin graft rejection; responses to MHC alloantigens, by contrast, are intense in all assays. Possible explanations for why thymic selection directed to a single peptide curtails self specificity without affecting alloreactivity are discussed. (+info)gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization. (2/12182)
We define by molecular, pharmacologic, and physiologic approaches the proximal mechanism by which the immunoglobulin superfamily member gp49B1 inhibits mast cell activation mediated by the high affinity Fc receptor for IgE (FcepsilonRI). In rat basophilic leukemia-2H3 cells expressing transfected mouse gp49B1, mutation of tyrosine to phenylalanine in either of the two immunoreceptor tyrosine-based inhibitory motifs of the gp49B1 cytoplasmic domain partially suppressed gp49B1-mediated inhibition of exocytosis, whereas mutation of both abolished inhibitory capacity. Sodium pervanadate elicited tyrosine phosphorylation of native gp49B1 and association of the tyrosine phosphatases src homology 2 domain-containing phosphatase-1 (SHP-1) and SHP-2 in mouse bone marrow-derived mast cells (mBMMCs). SHP-1 associated transiently with gp49B1 within 1 min after coligation of gp49B1 with cross-linked FcepsilonRI in mBMMCs. SHP-1-deficient mBMMCs exhibited a partial loss of gp49B1-mediated inhibition of FcepsilonRI-induced exocytosis at concentrations of IgE providing optimal exocytosis, revealing a central, but not exclusive, SHP-1 requirement in the counter-regulatory pathway. Coligation of gp49B1 with cross-linked FcepsilonRI on mBMMCs inhibited early release of calcium from intracellular stores and subsequent influx of extracellular calcium, consistent with SHP-1 participation. Because exocytosis is complete within 2 min in mBMMCs, our studies establish a role for SHP-1 in the initial counter-regulatory cellular responses whereby gp49B1 immunoreceptor tyrosine-based inhibition motifs rapidly transmit inhibition of FcepsilonRI-mediated exocytosis. (+info)Expression of neurotrophins and their receptors in human bone marrow. (3/12182)
The expression of neurotrophins and their receptors, the low-affinity nerve growth factor receptor (p75LNGFR) and the Trk receptors (TrkA, TrkB, and TrkC), was investigated in human bone marrow from 16 weeks fetal age to adulthood. Using reverse transcription-polymerase chain reaction, all transcripts encoding for catalytic and truncated human TrkB or TrkC receptors were detected together with trkAI transcripts, whereas trkAII transcripts were found only in control nerve tissues. Transcripts for the homologue of the rat truncated TrkC(ic113) receptor were identified for the first time in human tissue. Stromal adventitial reticular cells were found immunoreactive for all neutrophin receptors. In contrast, hematopoietic cell types were not immunoreactive for p75LNGFR but showed immunoreactivity for one or several Trk receptors. TrkA immunoreactivity was found in immature erythroblasts. Catalytic TrkB immunoreactivity was observed in eosinophilic metamyelocytes and polymorphonuclear cells. Truncated TrkB immunoreactivity was found in erythroblasts and megacaryocytes. Immunoreactivity for both catalytic and truncated TrkC receptor was observed in promyelocytes, myelocytes, some polymorphonuclear cells and megacaryocytes. Neutrophin transcript levels appeared higher at fetal than at adult stages, no variation in Trk family transcript levels was observed. The local expression of neurotrophin genes suggests a wide range of paracrine and/or autocrine mode of action through their corresponding receptors within the bone marrow. (+info)Disproportionate recruitment of CD8+ T cells into the central nervous system by professional antigen-presenting cells. (4/12182)
Inappropriate immune responses, thought to exacerbate or even to initiate several types of central nervous system (CNS) neuropathology, could arise from failures by either the CNS or the immune system. The extent that the inappropriate appearance of antigen-presenting cell (APC) function contributes to CNS inflammation and pathology is still under debate. Therefore, we characterized the response initiated when professional APCs (dendritic cells) presenting non-CNS antigens were injected into the CNS. These dendritic cells expressed numerous T-cell chemokines, but only in the presence of antigen did leukocytes accumulate in the ventricles, meninges, sub-arachnoid spaces, and injection site. Within the CNS parenchyma, the injected dendritic cells migrated preferentially into the white matter tracts, yet only a small percentage of the recruited leukocytes entered the CNS parenchyma, and then only in the white matter tracts. Although T-cell recruitment was antigen specific and thus mediated by CD4+ T cells in the models used here, CD8+ T cells accumulated in numbers equal to or greater than that of CD4+ T cells. Few of the recruited T cells expressed activation markers (CD25 and VLA-4), and those that did were primarily in the meninges, injection site, ventricles, and perivascular spaces but not in the parenchyma. These results indicate that 1) the CNS modulates the cellular composition and activation states of responding T-cell populations and that 2) myelin-restricted inflammation need not be initiated by a myelin-specific antigen. (+info)Detection of Kaposi's sarcoma herpesvirus DNA sequences in multiple myeloma bone marrow stromal cells. (5/12182)
Whether Kaposi's sarcoma herpesvirus (KSHV) is associated with multiple myeloma (MM) remains controversial. We assayed for KSHV DNA sequences in long-term bone marrow stromal cells (BMSCs) from 26 patients with MM and 4 normal donors. Polymerase chain reaction (PCR) using primers which amplify a KSHV gene sequence to yield a 233-bp fragment (KS330233 within open reading frame 26) was negative in all cases. Aliquots of these PCR products were used as templates in subsequent nested PCR, with primers that amplify a 186-bp product internal to KS330233. BMSCs from 24 of 26 (92%) patients with MM and 1 of 4 normal donors were KSHV PCR+. DNA sequence analyses showed interpatient specific mutations (2 to 3 bp). Both Southern blot and sequence analyses confirmed the specificity of PCR results. The presence of the KSHV gene sequences was further confirmed by amplifying T 1.1 (open reading frame [ORF] K7) and viral cyclin D (ORF 72), two other domains within the KSHV genome. Immunohistochemical studies of KSHV PCR+ MM BMSCs demonstrate expression of dendritic cell (DC) lineage markers (CD68, CD83, and fascin). Serological studies for the presence of KSHV lytic or latent antibodies were performed using sera from 53 MM patients, 12 normal donors, and 5 human immunodeficiency virus (HIV)/KSHV+ patients. No lytic or latent antibodies were present in sera from either MM patients or normal donors. Taken together, these findings show that KSHV DNA sequences are detectable in BMSCs from the majority of MM patients, but that serologic responses to KSHV are not present. Ongoing studies are defining whether the lack of antibody response is caused by the absence of ongoing infection, the presence of a novel viral strain associated with MM, or underlying immunodeficiency in these patients. (+info)Bone marrow and peripheral blood dendritic cells from patients with multiple myeloma are phenotypically and functionally normal despite the detection of Kaposi's sarcoma herpesvirus gene sequences. (6/12182)
Multiple myeloma (MM) cells express idiotypic proteins and other tumor-associated antigens which make them ideal targets for novel immunotherapeutic approaches. However, recent reports show the presence of Kaposi's sarcoma herpesvirus (KSHV) gene sequences in bone marrow dendritic cells (BMDCs) in MM, raising concerns regarding their antigen-presenting cell (APC) function. In the present study, we sought to identify the ideal source of DCs from MM patients for use in vaccination approaches. We compared the relative frequency, phenotype, and function of BMDCs or peripheral blood dendritic cells (PBDCs) from MM patients versus normal donors. DCs were derived by culture of mononuclear cells in the presence of granulocyte-macrophage colony-stimulating factor and interleukin-4. The yield as well as the pattern and intensity of Ag (HLA-DR, CD40, CD54, CD80, and CD86) expression were equivalent on DCs from BM or PB of MM patients versus normal donors. Comparison of PBDCs versus BMDCs showed higher surface expression of HLA-DR (P =.01), CD86 (P =. 0003), and CD14 (P =.04) on PBDCs. APC function, assessed using an allogeneic mixed lymphocyte reaction (MLR), demonstrated equivalent T-cell proliferation triggered by MM versus normal DCs. Moreover, no differences in APC function were noted in BMDCs compared with PBDCs. Polymerase chain reaction (PCR) analysis of genomic DNA from both MM patient and normal donor DCs for the 233-bp KSHV gene sequence (KS330233) was negative, but nested PCR to yield a final product of 186 bp internal to KS330233 was positive in 16 of 18 (88.8%) MM BMDCs, 3 of 8 (37.5%) normal BMDCs, 1 of 5 (20%) MM PBDCs, and 2 of 6 (33.3%) normal donor PBDCs. Sequencing of 4 MM patient PCR products showed 96% to 98% homology to the published KSHV gene sequence, with patient specific mutations ruling out PCR artifacts or contamination. In addition, KHSV-specific viral cyclin D (open reading frame [ORF] 72) was amplified in 2 of 5 MM BMDCs, with sequencing of the ORF 72 amplicon revealing 91% and 92% homology to the KSHV viral cyclin D sequence. These sequences again demonstrated patient specific mutations, ruling out contamination. Therefore, our studies show that PB appears to be the preferred source of DCs for use in vaccination strategies due to the ready accessibility and phenotypic profile of PBDCs, as well as the comparable APC function and lower detection rate of KSHV gene sequences compared with BMDCs. Whether active KSHV infection is present and important in the pathophysiology of MM remains unclear; however, our study shows that MMDCs remain functional despite the detection of KSHV gene sequences. (+info)Effects of short-term administration of G-CSF (filgrastim) on bone marrow progenitor cells: analysis of serial marrow samples from normal donors. (7/12182)
To determine the effect of G-CSF administration on both the total number of CD34+ cells and the primitive CD34+ subsets in bone marrow (BM), we have analyzed BM samples serially obtained from 10 normal donors in steady-state and during G-CSF treatment. Filgrastim was administered subcutaneously at a dosage of 10 microg/kg/day (n = 7) or 10 microg/kg/12 h (n = 3) for 4 consecutive days. Peripheral blood sampling and BM aspirates were performed on day 1 (just before G-CSF administration), day 3 (after 2 days of G-CSF), and day 5 (after 4 days of G-CSF). During G-CSF administration, a significant increase in the total number of BM nucleated cells was observed. The percentage (range) of CD34+ cells decreased in BM from a median of 0.88 (0.47-1.44) on day 1 to 0.57 (0.32-1.87), and to 0.42 (0.16-0.87) on days 3 and 5, respectively. We observed a slight increase in the total number of BM CD34+ cells on day 3 (0.66 x 10(9)/l (0.13-0.77)), and a decrease on day 5 (0.23 x 10(9)/l (0.06-1.23)) as compared with steady-state (0.40 x 10(9)/l (0.06-1.68)). The proportion of primitive BM hematopoietic progenitor cells (CD34+CD38-, CD34+HLA-DR-, CD34+CD117-) decreased during G-CSF administration. In parallel, a significant increase in the total number of CD34+ cells in peripheral blood was observed, achieving the maximum value on day 5. These results suggest that in normal subjects the administration of G-CSF for 5 days may reduce the number of progenitor cells in BM, particularly the most primitive ones. (+info)Immunoregulatory cytokines in bone marrow and peripheral blood stem cell products. (8/12182)
In these studies, we compared the phenotype, function, and expression of type 1, type 2, and monocyte-associated cytokine mRNA transcripts in autologous bone marrow (BM) and growth factor-mobilized peripheral blood stem cell (PSC) products. These studies demonstrate that lymphocytes and monocytes in stem cell products are abnormally activated, expressing significantly higher levels of interleukin (IL)-2, 4 and 10, interferon gamma (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha), but not IL-8, as compared to normal peripheral blood mononuclear cells (PBMC). In addition, the levels of IL-2, IL-10 and TNF-alpha are significantly higher in mobilized PSC as compared to BM products. The high cytokine levels are unexpected as T cell function in stem cell products is depressed. PSC products have high levels of T cell inhibitory activity, which directly correlates with IL-10 expression, both of which are mechanisms that might be involved in the immune dysfunction within stem cell products used for autologous stem cell transplantation. These data demonstrate that: (1) immune cells in autologous BM and PSC products are activated with the expression of high levels of type 1 and type 2 cytokines as well as monokines; (2) PSC products contain a high frequency of monocytes which mediate T cell inhibitory activity; and (3) despite the high levels of cytokine expression, T cell function in stem cell products is depressed. The significance of these immune abnormalities within stem cell products for myeloid and lymphoid recovery following autologous stem cell transplantation remains to be determined. (+info)
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Cernunnos deficiency
"Bone Marrow (Hematopoietic) Stem Cells , stemcells.nih.gov". stemcells.nih.gov. Retrieved 2017-07-13. Sullivan, Kathleen E.; ... which are stem cells that bring about other cells) has proven useful in some instances. Additionally the following treatments ... V(D)J recombination is a genetic recombination that happens in early stages of B and T cell maturation. The diagnosis of ... Recurrent infections Microcephaly Growth retardation Bone-malformation Dysmorphic feature Urogenital malformations In terms of ...
Bone marrow
Several types of stem cells are related to bone marrow. Hematopoietic stem cells in the bone marrow can give rise to ... Bone marrow examination is the pathologic analysis of samples of bone marrow obtained via biopsy and bone marrow aspiration. ... The bone marrow stroma contains mesenchymal stem cells (MSCs), which are also known as marrow stromal cells. These are ... bone marrow is the primary site of new blood cell production (or haematopoiesis). It is composed of hematopoietic cells, marrow ...
GRID2
Hess DC, Hill WD, Carroll JE, Borlongan CV (Apr 2004). "Do bone marrow cells generate neurons?". Archives of Neurology. 61 (4 ... Kemp K, Wilkins A, Scolding N (Nov 2014). "Cell fusion in the brain: two cells forward, one cell back". Acta Neuropathologica. ... "Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes". Nature. 425 (6961): 968-73. Bibcode ... "Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant". Nature Cell Biology. 5 ...
Temozolomide
"Investigative Engineered Bone Marrow Cell Therapy". Fred Hutchinson Cancer Research Center. 2011-05-23. Dall'oglio S, D'Amico A ... Cells may grow and pass through the cell cycle normally without arrest or death. However, some tumors cells are MGMT deficient ... In cells with MGMTd, DNA damage by TMZ activates the next stage of repair in cells with a proficient Mismatch Repair enzyme ... The most common side effect is bone marrow suppression. The most common non-hematological adverse effects associated with ...
Purkinje cell
There is evidence in mice and humans that bone marrow cells either fuse with or generate cerebellar Purkinje cells, and it is ... with basket cells synapsing on the Purkinje cell axon initial segment and stellate cells onto the dendrites. Purkinje cells ... possible that bone marrow cells, either by direct generation or by cell fusion, could play a role in repair of central nervous ... Hess DC, Hill WD, Carroll JE, Borlongan CV (2004). "Do bone marrow cells generate neurons?". Archives of Neurology. 61 (4): 483 ...
Thymidine kinase in clinical chemistry
Wickramasinghe SN, Olsen I, Saunders JE (1975). "Thymidine kinase activity in human bone marrow cells". Scandinavian Journal of ... is cell cycle-independent. TK1 is synthesized by the cell during the S phase of cell division. After cell division is completed ... in peripheral lymphocytes during monocytosis and in bone marrow during pernicious anemia. As TK1 is present in cells during ... Enzymes of thymidine and thymidylate metabolism in normal and pathological blood and bone marrow cells]". Blut (in German). 25 ...
Granulopoiesis
These are multipotent cells that reside in the bone marrow niche and have the ability to give rise to all haematopoietic cells ... expression in bone marrow and fractionated marrow cell populations by interleukin 3 (IL-3): IL-3-mediated positive feedback ... These are secreted by other haematopoietic cells in the bone marrow or at the site of inflammation as well as epithelial and ... Bendall, Linda J.; Bradstock, Kenneth F. (2014-08-01). "G-CSF: From granulopoietic stimulant to bone marrow stem cell ...
Multiple Sclerosis Trust
"Bone marrow cell treatment for chronic multiple sclerosis". MS Trust website. Retrieved 29 November 2012. "Pilates based core ... Research currently being funded includes: University of Bristol, Bone marrow cell treatment for chronic multiple sclerosis ...
Homing (hematopoietic)
... in the bone marrow. Various chemokines and receptors are involved in the homing of hematopoietic stem cells. Bone marrow Lymph ... Yusuf, Rushdia Z.; Scadden, David T. (17 March 2009). "Homing of Hematopoietic Cells to the Bone Marrow". Journal of Visualized ... Homing is the phenomenon whereby cells migrate to the organ of their origin. By homing, transplanted hematopoietic cells are ... "Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic ...
Graft-versus-host disease
GvHD is commonly associated with bone marrow transplants and stem cell transplants. White blood cells of the donor's immune ... International Bone Marrow Transplant Registry". Bone Marrow Transplantation. 24 (3): 283-7. doi:10.1038/sj.bmt.1701899. PMID ... "Stem Cell or Bone Marrow Transplant Side Effects". www.cancer.org. Retrieved 2020-09-01. Goker H, Haznedaroglu IC, Chao NJ ( ... After bone marrow transplantation, T cells present in the graft, either as contaminants or intentionally introduced into the ...
Perivascular space
Morrison, S. J; Scadden, D. T (2014). "The bone marrow niche for haematopoietic stem cells". Nature. 505 (7483): 327-334. ... Often, cell debris and foreign particles, which are impermeable to the BBB will get through the endothelial cells, only to be ... The production of cAMP aids in the modulation of auto-reactive T cells by regulatory T cells. . The perivascular space is ... This holds true for many T and B cells, as well as monocytes, giving this small fluid filled space an important immunological ...
Monocyte
... s are produced by the bone marrow from precursors called monoblasts, bipotent cells that differentiated from ... "Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes". Circulation. 142 (3): 244-258. doi:10.1161/CIRCULATIONAHA. ... which activates CD4 Th2 cells and inhibits CD4 Th1 cell function. Many factors produced by other cells can regulate the ... With a diameter of 15-22 μm, monocytes are the largest cell type in peripheral blood. Monocytes are mononuclear cells and the ...
Belimumab
BAFF is secreted by a variety of cells: monocytes and macrophages; bone marrow stromal cells; astrocytes in certain ... B cells develop in the bone marrow and continue to mature peripherally in secondary lymphoid organs and in the gut. When ... Belimumab binds to BAFF and prevents it from binding to B cells. Without BAFF, B cells commit suicide and no longer contribute ... Researchers theorize that SLE is caused when autoimmune B cells proliferate and survival factors protect them from cell suicide ...
Philip Lazarovici
"Vasculogenic mimicry of acute leukemic bone marrow stromal cells". Leukemia. 23 (6): 1039-1048. doi:10.1038/leu.2009.10. PMID ... Vaudry, D.; Stork, PJ; Lazarovici, P; Eiden, LE (31 May 2002). "Signaling Pathways for PC12 Cell Differentiation: Making the ... in PC12 Cells". Journal of Molecular Neuroscience. 54 (3): 574-585. doi:10.1007/s12031-014-0388-2. PMID 25078264. S2CID 1620005 ... Endothelial Cell Tube Formation Assay". Neurotrophic Factors. Methods in Molecular Biology. Vol. 1727. pp. 239-250. doi:10.1007 ...
Monoclonal gammopathy of undetermined significance
Plasma cells less than 10% on bone marrow examination; No evidence of bone lesions, anemia, hypercalcemia, or chronic kidney ... There is a predominance of clonal plasma cells in the bone marrow with an abnormal immunophenotype (CD38+ CD56+ CD19−) mixed in ... MGUS is a common, age-related medical condition characterized by an accumulation of bone marrow plasma cells derived from a ... white blood cells that secrete antibodies) in the bone marrow is lower, and it rarely has symptoms or major problems. However, ...
Epstein-Barr virus-associated lymphoproliferative diseases
... red blood cells, and platelets), hemophagocytosis (i.e. ingestion of blood cells by histiocytes) in bone marrow and spleen), a ... CD4+ T cells (i.e. T helper cells), CD8+ cells (i.e. cytotoxic T cells), NK cells (i.e. natural killer cells). The mechanism by ... NK cells), Gamma delta T cells (γδ T cells), cytotoxic T cells (CTL), helper T cells (Th cells), and follicular B helper T ... a type of white blood cell), i.e. B cells, T cells, NK cells, and histiocytic-dendritic cells, are infected with the Epstein- ...
Mir-154 microRNA precursor family
Debernardi S, Dixon-McIver A (2010). "MicroRNA detection in bone marrow cells by LNA-FISH". MicroRNAs and the Immune System. ... Wong TS, Liu XB, Wong BY, Ng RW, Yuen AP, Wei WI (May 2008). "Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell ... Choong ML, Yang HH, McNiece I (April 2007). "MicroRNA expression profiling during human cord blood-derived CD34 cell ... "Differential microRNA expression in peripheral blood mononuclear cells from Graves' disease patients". The Journal of Clinical ...
Thrombopoiesis
Boes KM, Durham AC (February 2017). "Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic System.". Pathologic Basis of ... Thrombopoiesis is the formation of thrombocytes (blood platelets) in the bone marrow. Thrombopoietin is the main regulator of ... and supporting these cells so they mature to become platelet-producing cells. The process of Thrombopoiesis is caused by the ... Megakaryocytes are precursor cells that are highly specialized. Megakaryocytes give rise to 1,000 to 3,000 platelets. ...
Retinitis pigmentosa
MD Stem Cells, a clinical research company using autologous bone marrow derived stem cells (BMSC) in the treatment of retinal ... bone marrow derived stem cells in the treatment of Retinitis Pigmentosa. Stem Cell Investig. 2018 Jun 6;5:18. doi: 10.21037/sci ... "Bone Marrow Derived Stem Cell Ophthalmology Treatment Study II". 22 February 2021. {{cite journal}}: Cite journal requires , ... that protects the cone cells from apoptosis (cell death). However, when the rod cells die, this substance is no longer provided ...
Pepducin
A CXCR4 agonist pepducin mobilizes bone marrow hematopoietic cells. A PAR1 pepducin, PZ-128, has successfully completed phase I ... "Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells". 2010. Archived from the original on 2011 ... Pepducins are cell-penetrating peptides that act as intracellular modulators of signal transference from receptors to G ... This structure allows pepducin lipopeptides to anchor in the cell membrane lipid bilayer and target the GPCR/G protein ...
Monoclonal B-cell lymphocytosis
... of all nucleated cells in the marrow. Regardless of the percentage of these cells, the presence of monoclonal B cells in bone ... Most individuals with MBL have at presentation an abnormal infiltrate of monoclonal B-cells in their bone marrow as determined ... Wotherspoon A, Attygalle A, Mendes LS (December 2015). "Bone marrow and splenic histology in hairy cell leukaemia". Best ... These cells, similar to the monoclonal cells in Hairy cell leukemia, may have the V600E mutation in the BRAF gene. Patients ...
Peripheral stem cell transplantation
... where the transplanted cells override the previous bone marrow. This allows the bone marrow to recover, proliferate and ... The administered hematopoietic stem cells then migrate to the recipient's bone marrow, through a process known as stem cell ... CD34+ cells) yield. Immature hematopoietic stem cells in the circulating blood that are similar to those in the bone marrow are ... randomized study of allogeneic marrow vs blood stem cell transplantation". Bone Marrow Transplantation. 25 (5): 501-5. doi: ...
Stargardt disease
MD Stem Cells, a research-physician clinical development company using autologous bone marrow derived stem cells (BMSC), has ... "Bone Marrow Derived Stem Cell Ophthalmology Treatment Study II". 8 September 2021. {{cite journal}}: Cite journal requires , ... Stem-cell therapy involves injecting cells with the potential to mature into differentiated and functioning retinal cells. This ... Bone Marrow-Derived Stem Cells in the Treatment of Stargardt Disease". Medicines. 8 (2): 10. doi:10.3390/medicines8020010. PMC ...
BST1
... a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth". Proc Natl Acad Sci U S A. 91 (12): ... Bst1 (Bone marrow stromal cell antigen 1, ADP-ribosyl cyclase 2, CD157) is an enzyme that in humans is encoded by the BST1 gene ... "Entrez Gene: BST1 bone marrow stromal cell antigen 1". Quarona V, Zaccarello G, Chillemi A (2013). "CD38 and CD157: a long ... 1996). "Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe ...
New York Blood Center
Bone Marrow Cells - Advances in Research Application: 2013 Edition. ScholarlyEditions. ISBN 9781481698047 - via Google Books. ... "FDNY Honors Life-Saving Bone Marrow Donors". CBS New York. Retrieved 6 October 2016. Daily News (29 April 2016). "Bone marrow ... FDNY members represent more than 10% of all NYBC bone marrow donors. Each year, at an annual induction ceremony hosted by FDNY ... FDNY Press Office (29 April 2016). "Fire Commissioner and New York Blood Center Honor FDNY Bone Marrow Donors". Fire Department ...
Immunology & Cell Biology
Bradley, T. R.; Metcalf, D. (1966). "The growth of mouse bone marrow cells in vitro". {{cite journal}}: Cite journal requires , ... Immunology & Cell Biology is an academic journal of the Australian and New Zealand Society for Immunology covering basic ... and was converted in 1987 to Immunology and Cell Biology, making it one of the oldest speciality immunology journals in ...
Autologous stem-cell transplantation
"Autologous bone-marrow stem-cell transplantation for myocardial regeneration". The Lancet. 361 (9351): 45-46. doi:10.1016/S0140 ... Autologous hematopoietic stem-cell transplantation Stem-cell therapy "What Are Stem Cells?". Retrieved 2017-02-12. Mahla RS ( ... transplantation in which stem cells (undifferentiated cells from which other cell types develop) are removed from a person, ... precursors of blood-forming cells) in hematopoietic stem cell transplantation, cardiac cells have also been used successfully ...
Fanconi anemia
Treatment with androgens and hematopoietic (blood cell) growth factors can help bone marrow failure temporarily, but the long- ... The last major haematological complication associated with FA is bone marrow failure, defined as inadequate blood cell ... Senescence, together with apoptosis, may constitute a major mechanism of haemopoietic cell depletion occurred in bone marrow ... investigates the mechanism of bone marrow failure in FANCC-/- cells. They hypothesize and successfully demonstrate that ...
Body memory
Di Rosa F, Pabst R (2005). "The bone marrow: a nest for migratory memory T cells". Trends Immunol. 26 (7): 360-6. doi:10.1016/j ... innate immune memory in stromal cells, fungal mediation of innate and inherited immunological response, and T and B-cell immune ... Cellular memory (CM) is a parallel hypothesis to BM positing that memories can be stored outside the brain in all cells. The ... enables the immune system to learn to react to pathogens through mechanisms such as cytoxic memory mediation in bone marrow, ...
UBL7
Ubiquitin-like 7 (bone marrow stromal cell-derived) is a protein in humans that is encoded by the UBL7 gene. ENSG00000288408 ... "Entrez Gene: Ubiquitin-like 7 (bone marrow stromal cell-derived)". Retrieved 2013-07-09. Overview of all the structural ...
Firestone Institute for Respiratory Health
... of airway hyperresponsiveness and airway remodelling Trafficking and lung homing of bone-marrow derived hemopoietic stem cells ...
Signet ring cell carcinoma
"Bone marrow infiltration as the initial presentation of gastric signet ring cell adenocarcinoma". Journal of Gastrointestinal ... studies indicate that bone marrow metastases will likely play a larger role in the diagnosis and management of signet ring cell ... Some cases are inherited, and these cases are often caused by mutations in the CDH1 gene, which encodes the important cell-cell ... As a result, the ErbB2/ErbB3 signaling pathway becomes constitutively activated, cell-cell interactions are lost and signet ...
Febrile neutropenia
... suppresses the bone marrow from producing blood cells).[citation needed] The Multinational Association for Supportive Care in ... a type of white blood cell) in the blood. The term neutropenic sepsis is also applied, although it tends to be reserved for ...
Follicular dendritic cells
Unlike dendritic cells (DC), FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin. ... and differentiation into high-affinity plasma cells and memory B cells. Adhesion between FDCs and B cells is mediated by ICAM-1 ... Activated B-cells with low affinity to antigen captured on FDCs surface as well as autoreactive B-cells undergo apoptosis, ... Follicular dendritic cells (FDC) are cells of the immune system found in primary and secondary lymph follicles (lymph nodes) of ...
Clonal deletion
If autoreactive cells escape clonal deletion in either the thymus or the bone marrow, there are mechanisms in the periphery ... B cells demonstrating high affinity for self antigen can undergo clonal deletion within the bone marrow. This occurs after the ... There are millions of B and T cells inside the body, both created within the bone marrow and the latter matures in the thymus, ... Such T cells are often removed via clonal deletion, leaving autoreactive B cells unstimulated and unactivated. These B cells do ...
Pegcetacoplan
... red blood cells unable to carry enough oxygen to tissues), blood clots, and impaired bone marrow function (not making enough ... Paroxysmal nocturnal hemoglobinuria is characterized by red blood cell destruction, anemia ( ... blood cells). Pegcetacoplan is the first treatment for paroxysmal nocturnal hemoglobinuria that binds to and inhibits ...
CD34
Cells expressing CD34 (CD34+ cell) are normally found in the umbilical cord and bone marrow as haematopoietic cells, or in ... December 2019). "Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia ... It may also mediate the attachment of hematopoietic stem cells to bone marrow extracellular matrix or directly to stromal cells ... and expression of a novel hematopoietic cell antigen from CD34+ human bone marrow cells". Blood. 89 (8): 2706-2716. doi:10.1182 ...
Kiran Mazumdar-Shaw
In 2011, she added a center for advanced therapeutics with a bone marrow transplant unit and a research center. Her goal is to ... Yeast expression platforms offer a desirable alternative to mammalian cell cultures for the genetic manipulation of cells for ... "Biocon to invest in cell for innovation at ISB". Business Line. 9 June 2009. Retrieved 23 September 2014. Panthry, Pallavee ... 117 She funded a multi-year research program by creating the Biocon Cell for Innovation Management with Prasad kaipa at the ...
Myelopoiesis
In hematology, myelopoiesis in the broadest sense of the term is the production of bone marrow and of all cells that arise from ... The common myeloid progenitor can differentiate in the bone marrow into red blood cells and megakaryocytes (leading to ... A granulocyte differentiates into a distinct cell type by a process called granulopoiesis. In this process it first transforms ... The granulocytes, also called polymorphonuclear leukocytes because of their multilobed nuclei, are three short lived cell types ...
Ancestim
Bone Marrow Transplant. 34 (8): 683-91. doi:10.1038/sj.bmt.1704602. PMID 15322567. "{{Webarchive,url=https://web.archive.org/ ... It is a 166 amino acid protein produced by E. coli bacteria into which a gene has been inserted for soluble human stem cell ... Ancestim is a recombinant methionyl human stem cell factor, branded by Amgen as StemGen. It was developed by Amgen and sold to ... 2004). "Ancestim (recombinant human stem cell factor, SCF) in association with filgrastim does not enhance chemotherapy and/or ...
ATP11C
"The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434-40. doi: ... The corresponding protein in mice is essential for the development of B cells and red blood cells, and for the prevention of ...
Rockwell Medical
Triferic delivers iron directly to transferrin which transported it to the bone marrow to make hemoglobin. Rockwell is actively ... a key element in the formation of new red blood cells. It was licensed in 2011 for the delivery of iron supplementation for ...
Lipid storage disorder
... and bone marrow. Inside cells under normal conditions, lysosomes convert, or metabolize, lipids and proteins into smaller ... Furthermore, gene therapies and bone marrow transplantation may prove to be effective for certain lipid storage disorders. Diet ... These tests include clinical examination, biopsy, genetic testing, molecular analysis of cells or tissues, and enzyme assays. ... is any one of a group of inherited metabolic disorders in which harmful amounts of fats or lipids accumulate in some body cells ...
Peter Klinken
Transformation of murine bone marrow cells with a raf/myc retrovirus yields clonally related mature B cells and macrophages. ... Cell 53:857-867 (1988) In vitro derived leukaemic erythroid cell lines induced by a raf/myc retrovirus differentiate in ... Cell 65:1-10 (1991) Erythropoietin-induced stimulation of differentiation and proliferation in J2E cells is not mimicked by ... Klinken's research interests include the regulation of red blood cell formation, and the ability of leukaemic cells to develop ...
CD96
June 2011). "[CD96 expression on bone marrow mononuclear cells in 91 patients with acute leukemia]". Zhongguo Shi Yan Xue Ye ... The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the ... CD96 is a receptor protein which is expressed on T cells and NK cells and shares sequence similarity with CD226 (also known as ... Fuchs A, Cella M, Giurisato E, Shaw AS, Colonna M (April 2004). "Cutting edge: CD96 (tactile) promotes NK cell-target cell ...
Dorothy Bainton
Her research focused on differentiation of cells in bone marrow and the development of blood cancers. 1990 Elected member of ...
Iron overload
... hemolysis within the bone marrow) Multiple frequent blood transfusions (either whole blood or just red blood cells), which are ... Hemosiderosis is hemosiderin deposition within cells, while hemochromatosis is hemosiderin within cells and interstitium. ... metabolism: diabetes in people with iron overload occurs as a result of selective iron deposition in islet beta cells in the ... Iron, which makes up 70% of red blood cell composition, is a critical micronutrient for effective thermoregulation in the body ...
Osteochondroprogenitor cell
Osteochondroprogenitor cells are progenitor cells that arise from mesenchymal stem cells (MSC) in the bone marrow. They have ... before any genetic or morphological criteria were put in place for bone marrow or connective tissues. Osteoprogenitor cells can ... giving rise to either bone or cartilage respectively. Osteochondroprogenitor cells are important for bone formation and ... Osteoblasts are cells that group together to form units, called osteons, to produce bone. Runx2 (which may also be known as ...
Nintendo thumb
"Palmar Eccrine Hidradenitis Secondary to Trauma from Computer Gaming in an Adolescent After Bone Marrow Transplantation". ... Hidradenitis has been diagnosed through an examination to confirm the presence of neutrophils (a type of immune cell present ... "Inflammation of sites where tendons and ligaments are attached to the bone"), and epicondylitis (degeneration of the origin of ...
Guido Banti
... bone marrow and lymph glands, and that they are the result of the uncontrolled proliferation of staminal blood cells. This ... Banti proposed that the enlarged spleen was the cause of red cell destruction which led to anemia and that only removal of the ... He spent time studying cancer cells in 1890-93. 1894 he published a study of typhoid fever, Le setticemie tifiche (Florence). ...
C. Glenn Begley
Begley was also involved in more work with mice that found that bone marrow cells are not a contributor to endothelium of ... In 1999 he released an article which he was the co-author of that was solely on SCL and the relationship with T cells and T ... Begley, C. Glenn (2015). "My Tribute to a Real Master Craftsman, Don Metcalf". Stem Cells. 33 (5): 1683-1684. doi:10.1002/stem. ... Begley, C. Glenn (2015). "My Tribute to a Real Master Craftsman, Don Metcalf". Stem Cells. 33 (5): 1683-1684. doi:10.1002/stem. ...
Dock11
Subsequent RT-PCR analysis revealed expression of this protein in the spleen, thymus, bone marrow and in peripheral blood ... Côté JF, Vuori K (August 2007). "GEF what? Dock180 and related proteins help Rac to polarize cells in new ways". Trends in Cell ... Meller N, Merlot S, Guda C (November 2005). "CZH proteins: a new family of Rho-GEFs". Journal of Cell Science. 118 (Pt 21): ... Dock11 is expressed at lower levels in NIH-3T3 fibroblasts, C2C12 myoblasts and Neuro-2A neuroblastoma cells. Dock11 mRNA has ...
Because of Mr. Terupt
Jeffrey, who has long felt guilty because his stem cell and bone marrow donations were unable to save his brother's life, ...
Blood doping
... is a glycoprotein hormone produced by the interstitial fibroblasts in the kidney that signal for erythropoiesis in bone marrow ... Because such blood cells carry oxygen from the lungs to the muscles, a higher concentration in the blood can improve an ... Blood doping is a form of doping in which the number of red blood cells in the bloodstream is boosted in order to enhance ... The freezing process, conversely, limits the aging of the cells, allowing the storage of the blood for up to 10 years with a 10 ...
Singapore Cord Blood Bank
Bone marrow disease: like Paroxysmal Nocturnal Hemoglobinuria 4. Sickle Cell Anemia's, 5. Thalassemia 6.Immune Deficiencies ... Blood stem cells are young or immature cells that can transform into other forms of essential blood cell types (pluripotent), ... such as red blood cells, white blood cells and platelets. The use of blood stem cells has emerged as a potentially curative ... matched stem cell units because of the relative scarcity of stem cell donors that matched Singapore's main ethnic profiles i.e ...
Factor XIII
A subunits of human factor XIII are made primarily by platelets and other cells of bone marrow origin. B subunits are secreted ... Dimers containing only A units also occur within cells such as platelets. Large quantities of singular B units (monomers) also ... determination of the presence of factor XIII may be used to identify and classify malignant diseases involving these cells. ...
Interleukin 3
IL-3 is secreted by basophils and activated T cells to support growth and differentiation of T cells from the bone marrow in an ... "Accelerated and longterm hematopoietic engraftment in mice transplanted with ex-vivo expanded bone marrow". Bone Marrow ... Peters SO, Kittler EL, Ramshaw HS, Quesenberry PJ (1996). "Ex-vivo expansion of murine marrow cells with IL-3, Il-6, Il-11 and ... However, only IL-3 treatment in bone marrow failure disorders such as myelodysplastic syndrome (MDS) and aplastic anemia (AA) ...
Voriconazole
... squamous cell skin cancer, and Stevens-Johnson syndrome; in long-term use there is a warning of the risk of bone fluorosis and ... including people undergoing allogeneic bone marrow transplant (BMT), who have hematologic cancers or who undergo organ ... It works by affecting fungal metabolism and fungal cell membranes. Voriconazole was patented in 1990 and approved for medical ... Hematology/Oncology and Stem Cell Therapy. 10 (4): 239-244. doi:10.1016/j.hemonc.2017.05.013. PMID 28636889. Herbrecht R, ...
Waldenström macroglobulinemia
Bone marrow tumour cells express the following antigen targets CD20 (98.3%), CD22 (88.3%), CD40 (83.3%), CD52 (77.4%), IgM ( ... A bone marrow biopsy provides a sample of bone marrow, usually from the lower back of the pelvis bone. The sample is extracted ... "Allogeneic bone marrow transplantation for advanced Waldenstrom's macroglobulinemia". Bone Marrow Transplant. 23 (7): 747-9. ... lymphoplasmacytoid cells and plasma cells. Both cell types are white blood cells. It is characterized by having high levels of ...
Human T-lymphotropic virus 1
Allogenic bone marrow transplantation has been investigated in the treatment of HTLV-1 disease with varied results. One case ... The virus activates a subset of T-helper cells called Th1 cells. The result is a proliferation of Th1 cells and overproduction ... including CD8+ T cells, dendritic cells and B cells. HTLV-I entry is mediated through interaction of the surface unit of the ... Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus (HTLV-I), also called the adult T-cell lymphoma virus type ...
Bone marrow (stem cell) donation: MedlinePlus Medical Encyclopedia
Bone marrow contains stem cells, which are immature cells that become blood cells. ... Bone marrow is the soft, fatty tissue inside your bones. ... Bone marrow contains stem cells, which are immature cells that ... Bone marrow donation can be done either by collecting a donors bone marrow surgically, or by removing stem cells from a ... bone marrow donation; Lymphoma - bone marrow donation; Myeloma - bone marrow donation ...
Patient's Own Bone Marrow Cells May Cure Drug-Resistant TB
Autologous mesenchymal stromal cells cured multidrug-resistant and extensively-drug-resistant tuberculosis in more than half of ... Infusion of a patients own bone marrow stem cells as an adjunct to antibiotic therapy for multidrug-resistant (MDR) or ... Cite this: Patients Own Bone Marrow Cells May Cure Drug-Resistant TB - Medscape - Jan 08, 2014. ... MSCs are also called mesenchymal stem cells and marrow stromal cells.). The researchers note that the immune response can ...
Viagra helps mobilize bone marrow stem cells | EurekAlert!
Life sciences/Cell biology/Cells/Stem cells/Hematopoietic stem cells * /Scientific community/Research programs/Stem cell ... Viagra helps mobilize bone marrow stem cells for transplantation in mice Peer-Reviewed Publication Cell Press ... Viagra helps mobilize bone marrow stem cells for transplantation in mice. Cell Press ... The researchers next harvested hematopoietic stem cells from the blood or bone marrow of donor mice treated with either ...
Autologous Bone Marrow Mononuclear Cells Intrathecal Transplantation in Chronic Stroke
In this study, the effect of intrathecal administration of autologous bone marrow mononuclear cells (BMMNCs) is analyzed on the ... Patients who underwent cell therapy within 2 years after the stroke showed better changes. Ischemic type of stroke had better ... 24 patients diagnosed with chronic stroke were administered cell therapy, followed by multidisciplinary neurorehabilitation. ... Cell therapy is being widely explored in the management of stroke and has demonstrated great potential. It has been shown to ...
Fraction of bone marrow cells that are mesenc - Human Homo sapiens - BNID 113200
Fraction of bone marrow cells that are mesenchymal stem cells (MSCs). Range. 0.01%-0.001% % ... P.171 right column 2nd paragraph: MSCs represent between 0.01% and 0.001% of all nucleated cells in adult human bone marrow, ... Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res. 2004 Jul 9 95(1):9-20. DOI: 10.1161/01.RES. ... Volume of cell and mass of protein in thymocyte (assuming protein concentration of 200 g/l). ...
A Few Cells Could Prevent Bone Marrow Transplant Infections
"Our study suggests that, in addition to infusing stem cells that restore the bone marrow, life-long anti-CMV immunity may be ... A Few Cells Could Prevent Bone Marrow Transplant Infections. .social-ris-container { display: flex; justify-content: space- ... His group showed that a small number of stem-cell like CD8 T cells -called "memory" cells -were enough to produce and ... but these are not always well tolerated by patients and they also harm the very cells that bone marrow transplantation aims to ...
Other Treatments for Hodgkin's Lymphoma: Bone Marrow and Peripheral Stem Cell Transplantation
bone marrow transplant treatment monograph.. Bone Marrow and Peripheral Stem Cell Transplantation. Bone marrow is a soft, ... Bone marrow contains immature cells called stem cells. Stem cells can mature into blood cells (white blood cells, red blood ... For a thorough description of bone marrow and peripheral stem cell transplantation, see the bone marrow transplant treatment ... from the bone marrow or blood, rather than from a donor. Hodgkins disease rarely affects the bone marrow, so cells from the ...
Intraspinal Transplantation of Autologous Neurogenically-Induced Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of...
Aim: To investigate the effects of neurogenically-induced autologous bone marrow-derived mesenchymal stem cells (NIBM-MSCs) in ... Intraspinal Transplantation of Autologous Neurogenically-Induced Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of ... Results: Two months after cell transplantation, there were no changes except for 1 gait score improvement for 1 of the cases. ...
Bone marrow stem-cell donation not a priority for 49% of South Africans, survey shows
A just-released survey conducted by the SA Bone Marrow Registry found that most South Africans are still confused about bone- ... marrow stem-cell donation, which is preventing them from becoming donors... ... "Bone marrow stem cell donation is not a blood transfusion. When stem cells are harvested peripherally, blood is drawn from one ... Bone marrow stem-cell donation not a priority for 49% of South Africans, survey shows ...
A Global Expanded Access Protocol on Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicle Infusion Treatment for...
Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19. Stem Cells Dev. 2020 Jun 15;29(12): ... Infusion Treatment Using Bone Marrow Mesenchymal Stem Cell (bmMSC) Derived Extracellular Vesicle Product, ExoFlo™, for COVID-19 ... Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment: A Global Expanded Access Protocol for ... Biological: Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment Intravenous Infusion over 60 ...
Abnormality of multiple cell lineages in the bone marrow - Ontology Browser - Rat Genome Database
Abnormality of multiple cell lineages in the bone marrow (HP:0012145). Annotations: Rat: (0) Mouse: (0) Human: (193) Chinchilla ... Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data ... Abnormality of bone marrow stromal cells Abnormality of multiple cell lineages in the bone marrow + ...
ABMDR : Armenian Bone Marrow Donor Registry |
ABMDR performs first-ever stem cell harvesting procedure in Yerevan
... and can store and harvest stem cells provided by healthy bone marrow donors. The stem cells subsequently can be utilized in ... Thanks to the procedure, during which stem cells were harvested from a healthy donor, a bone marrow transplant was performed in ... "With the successful completion of our first-ever stem cell harvesting procedure, which made possible a life-saving bone marrow ... In addition to recruiting bone marrow donors, these events will seek support for the establishment of a stem cell ...
Molecular Characterization Of Putative Mesenchymal Progenitor Cells From Equine Bone Marrow Aspirates
Bone marrow contains many cell types including hematopoietic cells and their precursors, adipocytes, endothelial cells, and ... Molecular Characterization Of Putative Mesenchymal Progenitor Cells From Equine Bone Marrow Aspirates. ... However, there is no consensus on their phenotype from uncultured bone marrow mononuclear cells (BMMNC) and poor understanding ... There are also cells with reported capacity to differentiate into bone, cartilage, and other tissues. Their descriptive ...
Fabrication and Paracrine Effect Research of Bone Marrow-Derived Endothelial Progenitor Cell Sheet | Research Square
... sheet-secreted paracrine factors is central to the mechanism by which these cells contribute to tissue repair. The purpose of ... The release of a wide array of endothelial progenitor cell (EPC) ... of cell sheet technology to bone marrow stromal cell ... SDF-1/CXCR4 axis in Tie2-lineage cells including endothelial progenitor cells contributes to bone fracture healing. J Bone ... Methods: EPCs derived from rat bone marrow (BM-EPC) were identified and isolated by the cell-surface markers CD34/CD133/VE- ...
Detecting Nucleated Cells in Bone Marrow Smears using Deep Learning | LUP Student Papers
Detecting Nucleated Cells in Bone Marrow Smears using Deep Learning. *Mark. Bram, Robin LU and Näsström, Mattias LU (2021) In ... Sometimes it is not enough to only investigate the peripheral blood but also samples from the bone marrow. The bone marrow is ... Sometimes it is not enough to only investigate the peripheral blood but also samples from the bone marrow. The bone marrow is ... Sometimes it is not enough to only investigate the peripheral blood but also samples from the bone marrow. The bone marrow is ...
Transcriptome Profiling Reveals Distinct Phenotype of Human Bone Marrow Mesenchymal Stem Cell-derived Hepatocyte-like cells
Background: Human bone marrow mesenchymal stem cell-derived hepatocyte-like cells (hBMSC-HLCs) are a promising alternative for ... Bone marrow mesenchymal stem cell (BMSC)-dervied hepatocyte-like cells (BMSC-HLCs) have the potential to overcome the ... Transcriptome Profiling Reveals Distinct Phenotype of Human Bone Marrow Mesenchymal Stem Cell-derived Hepatocyte-like cells ... Transcriptome Profiling Reveals Distinct Phenotype of Human Bone Marrow Mesenchymal Stem Cell-derived Hepatocyte-like cells. ...
Environment Changes Cause Adult Bone Marrow Stem Cells To Diversify - Stem Cell Institute Panama
... researchers have been able to make adult stem cells change and develop into organ producing cells. ... By manipulating the environment of adult stem cells, ... Bone marrow cells appear to have the capacity to replace any ... rigid bone cells, and soft muscle cells, by changing the environment of adult bone marrow cells. A rigid, stiff, or soft ... The bone marrow cells were encouraged by researchers at the University of California, Berkeley. It was there that the cells ...
Intrathymic inoculation of donor bone marrow cells prior to xenotransplantation of pig pancreatic islets into diabetic rats
Effects of adrenomedullin on acute ischaemia-induced collateral development and mobilization of bone-marrow-derived cells |...
Effects of adrenomedullin on acute ischaemia-induced collateral development and mobilization of bone-marrow-derived cells. Clin ... The HIF-1 response to simulated ischemia in mouse skeletal muscle cells neither enhances glycolysis nor prevents myotube cell ... Activation of Hypoxia-Inducible Factor 1 in Skeletal Muscle Cells After Exposure to Damaged Muscle Cell Debris ... Adrenomedullin as a Growth and Cell Fate Regulatory Factor for Adult Neural Stem Cells ...
Medical Science Monitor | Transplantation of bone marrow mononuclear cells enables simultaneous treatment with osteotomy for...
Bone marrow aspirates were obtained from the iliac crest and were centrifuged with a cell separator during the procedure of TRO ... Bone consolidation of transition zone on the cell-seeded femoral head was observed postoperatively at three or six months. The ... Transplantation of BMMNCs may be a beneficial treatment for bone repair in the condition of osteonecrosis. ... This case report documents the potential of BMMNCs with IP-CHA for bone repair at the lesion of osteonecrosis of the femoral ...
Bone marrow mononuclear cell therapy for acute myocardial infarction: we know what we want, but we just don't know how yet |...
Contrast this with the stem cell mania at the turn of the century, when a report that bone marrow-derived stem cells can ... Bone marrow mononuclear cell therapy for acute myocardial infarction: we know what we want, but we just dont know how yet ... Bone marrow mononuclear cell therapy for acute myocardial infarction: we know what we want, but we just dont know how yet ... Infusion of autologous bone marrow mononuclear cells (BMMCs) into the infarct-related coronary artery has been shown in ...
JCI Insight -
Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10
T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow. Cell Rep. 2017;18(8):1906-1916.. View this article via: ... CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine. Cell Stem Cell. ... Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem ... Profiling of bone marrow Tregs. (A) Representative plots of Foxp3+ cells. (B) Frequencies and absolute counts of Foxp3+ cells; ...
Bone Marrow Transplant (Stem Cell Transplant): Procedure, Type, Surgery & Treatment Cost | Narayana Health
A Comprehensive Guide about Stem Cell Transplant Procedure, Type, Surgery & Treatment Cost ... Bone Marrow FAQs. Why is bone marrow transplant done?. A bone marrow transplant is a medical procedure that is done to replace ... Bone marrow is a procedure performed to replace damaged or diseased bone marrow with healthy blood-forming stem cells. The bone ... The recipient of a bone marrow transplant has two DNA sets, and the bone marrow is responsible for creating blood cells. So, ...
Diversity of functional T-cell receptor delta-chain transcripts from bone marrow cells of athymic nude mice
Rearrangements of T-cell antigen receptor γ and δ chain genes are detected in the long-term cultured bone marrow cells of ... Rearrangements of T-cell antigen receptor gamma and delta chain genes are detected in the long-term cultured bone marrow cells ... Characterization of cells with T cell markers in athymic nude bone marrow and of their in vitro-derived clonal progeny. Journal ... Bone marrow cells of athymic nude mice express functional T cell receptor alpha chain transcripts rearranged to V delta 2, 3, 4 ...
Gene-modified stem cells help protect bone marrow from toxic side effects of chemotherapy for brain cancer
... and Cell Therapy in Seattle that one possible approach to reduce this toxic effect on bone marrow cells is to modify the cells ... it can also have a strong toxic effect on normal cells such as bone marrow and blood cells, often limiting the ability to use ... Although chemotherapy is used to kill cancer cells, ... Gene-modified stem cells help protect bone marrow from toxic ... and Cell Therapy in Seattle that one possible approach to reduce this toxic effect on bone marrow cells is to modify the cells ...
Synchronous mantle cell lymphoma bone marrow involvement complicated with extensive‑stage small cell lung cancer: A case report...
Synchronous mantle cell lymphoma bone marrow involvement complicated with extensive‑stage small cell lung cancer: A case report ... Loscocco GG, Piccini M, Bencini S and Vergoni F: Bone marrow involvement in small cell lung cancer. Hematol Transfus Cell Ther ... Synchronous mantle cell lymphoma bone marrow involvement complicated with extensive‑stage small cell lung cancer: A case report ... Synchronous mantle cell lymphoma bone marrow involvement complicated with extensive‑stage small cell lung cancer: A case report ...
Automated digital enumeration of plasma cells in bone marrow trephine biopsies of multiple myeloma | Journal of Clinical...
Alive but confused: heterogeneity of CD11c+ MHC class II+ cells in GM-CSF mouse bone marrow cultures | Crick
KAKEN - Research Projects | Neurotrophic and neuralizing activities of bone marrow stromal cells (KAKENHI-PROJECT-19591697)
Journal Article] Protection of dopamine neurons by bone marrow stromal cells2007. *. Author(s). Shintani Am, Nakao N, et al. ... Journal Article] Protection of dopamine neurons by bone marrow stromal cells2008. *. Author(s). Shintani A, Nakao N, et al ... The present study was designed to test the neurotrophic and neuralizing activities of bone marrow stromal cells (BMSC) derived ... of dopamine neurons from embryonic ste m cells in the presence of the neuralizin g activity of bone marrow stromal cells ...