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Bone Marrow ExaminationBone MarrowPancytopeniaBone Marrow CellsLymphohistiocytosis, HemophagocyticRed-Cell Aplasia, PureBone Marrow TransplantationTransplantation, HomologousHematopoietic Stem Cell TransplantationGraft vs Host DiseaseTransplantation ConditioningElectronic MailFood Dispensers, AutomaticEditorial PoliciesAuthorshipPeriodicals as TopicPostal ServiceInternetHematologic NeoplasmsBone and BonesLeukemiaMyelodysplastic-Myeloproliferative DiseasesBiopsy, NeedleHistiocytosis, Non-Langerhans-CellBone Marrow NeoplasmsBiopsy
Bone Marrow Examination: Removal of bone marrow and evaluation of its histologic picture.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Pancytopenia: Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Lymphohistiocytosis, Hemophagocytic: A group of related disorders characterized by LYMPHOCYTOSIS; HISTIOCYTOSIS; and hemophagocytosis. The two major forms are familial and reactive.Red-Cell Aplasia, Pure: Suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Transplantation Conditioning: Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Hematologic Neoplasms: Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)Myelodysplastic-Myeloproliferative Diseases: Clonal myeloid disorders that possess both dysplastic and proliferative features but are not properly classified as either MYELODYSPLASTIC SYNDROMES or MYELOPROLIFERATIVE DISORDERS.Biopsy, Needle: Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.Histiocytosis, Non-Langerhans-Cell: Group of disorders which feature accumulations of active HISTIOCYTES and LYMPHOCYTES, but where the histiocytes are not LANGERHANS CELLS. The group includes HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; SINUS HISTIOCYTOSIS; xanthogranuloma; reticulohistiocytoma; JUVENILE XANTHOGRANULOMA; xanthoma disseminatum; as well as the lipid storage diseases (SEA-BLUE HISTIOCYTE SYNDROME; and NIEMANN-PICK DISEASES).Bone Marrow Neoplasms: Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma. (1/9035)

Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that angiogenesis parallels progression of MM, and that MCs participate in its induction via angiogenic factors in their secretory granules.  (+info)

Granulocyte/macrophage colony-stimulating factor and interleukin-3 correct osteopetrosis in mice with osteopetrosis mutation. (2/9035)

Although young mice homozygous for the osteopetrosis (op) mutation usually developed prominent osteopetrosis, its severity was markedly reduced in aged op/op mice. This age-associated reversal of osteopetrosis was accompanied by the expansion of bone marrow cavities and increased numbers of tartrate-resistant acid phosphatase (TRAP)-positive cells and of macrophages in the bone marrow. The TRAP-positive cells were mononuclear and developed ruffled borders and numerous vesicles, vacuoles, and granules. Enzyme-linked immunosorbent assay demonstrated a significant elevation of serum granulocyte/ macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-3 levels in the aged op/op mice. To examine whether GM-CSF and/or IL-3 could correct osteopetrosis in young op/op mice, 5 ng of recombinant murine (rm)GM-CSF and/or 100 ng of rmIL-3 were injected daily into young op/op mice. In these treated young op/op mice, the bone marrow cavities were expanded significantly at 2 weeks after administration, associated with significantly increased numbers of TRAP-positive cells and bone marrow macrophages. TRAP-positive cells increased in number with days after injection. These results suggest that GM-CSF and IL-3 induce the development of osteoclasts to correct osteopetrosis in the op/op mice with aging.  (+info)

Organ-selective homing defines engraftment kinetics of murine hematopoietic stem cells and is compromised by Ex vivo expansion. (3/9035)

Hematopoietic reconstitution of ablated recipients requires that intravenously (IV) transplanted stem and progenitor cells "home" to organs that support their proliferation and differentiation. To examine the possible relationship between homing properties and subsequent engraftment potential, murine bone marrow (BM) cells were labeled with fluorescent PKH26 dye and injected into lethally irradiated hosts. PKH26(+) cells homing to marrow or spleen were then isolated by fluorescence-activated cell sorting and assayed for in vitro colony-forming cells (CFCs). Progenitors accumulated rapidly in the spleen, but declined to only 6% of input numbers after 24 hours. Although egress from this organ was accompanied by a simultaneous accumulation of CFCs in the BM (plateauing at 6% to 8% of input after 3 hours), spleen cells remained enriched in donor CFCs compared with marrow during this time. To determine whether this differential homing of clonogenic cells to the marrow and spleen influenced their contribution to short-term or long-term hematopoiesis in vivo, PKH26(+) cells were sorted from each organ 3 hours after transplantation and injected into lethally irradiated Ly-5 congenic mice. Cells that had homed initially to the spleen regenerated circulating leukocytes (20% of normal counts) approximately 2 weeks faster than cells that had homed to the marrow, or PKH26-labeled cells that had not been selected by a prior homing step. Both primary (17 weeks) and secondary (10 weeks) recipients of "spleen-homed" cells also contained approximately 50% higher numbers of CFCs per femur than recipients of "BM-homed" cells. To examine whether progenitor homing was altered upon ex vivo expansion, highly enriched Sca-1(+)c-kit+Lin- cells were cultured for 9 days in serum-free medium containing interleukin (IL)-6, IL-11, granulocyte colony-stimulating factor, stem cell factor, flk-2/flt3 ligand, and thrombopoietin. Expanded cells were then stained with PKH26 and assayed as above. Strikingly, CFCs generated in vitro exhibited a 10-fold reduction in homing capacity compared with fresh progenitors. These studies demonstrate that clonogenic cells with differential homing properties contribute variably to early and late hematopoiesis in vivo. The dramatic decline in the homing capacity of progenitors generated in vitro underscores critical qualitative changes that may compromise their biologic function and potential clinical utility, despite their efficient numerical expansion.  (+info)

Bone marrow ribonucleic acid polymerase. Effect of testosterone on nucleotide incorporation into nuclear RNA. (4/9035)

The incorporation of 3H-UTP into RNA by isolated rat bone marrow nuclei is stimulated by testosterone. This effect is hormone and tissue specific. Using alpha-amanitine and different ionic strength conditions it was found that testosterone enhances preferentially RNA polymerase I activity. The sedimentation pattern of RNA isolated from bone marrow nuclei shows that the synthesis of RNA species within the 14-30 S range is mainly stimulated by the hormone.  (+info)

In irradiation chimeras, K or D regions of the chimeric host, not of the donor lymphocytes, determine immune responsiveness of antiviral cytotoxic T cells. (5/9035)

The H-2 haplotype of the chimeric host determines the responder phenotype of maturing T cells. Spleen cells of chimeric mice formed when (K(k) nonresponder to D(b) x K(b) responder to D(b) plus vaccinia)F(1) bone marrow cells were used to reconstitute K(b)D(b) (C57BL/6 D(b) responder) irradiated recipients generated high levels of D(b) plus vaccinia virus-specific cytotoxic T cells. The same stem cells used to reconstitute K(k)D(b) (B10.A (2R) D(b) nonresponder) irradiated recipients resulted in spleen cells that responded well to K plus vaccinia, but responsiveness to D(b) was low. A generally low response to D(k) plus vaccinia, which seems to be regulated by D(k), was confirmed in chimeras. Thus, K(d)D(d) (D(d) plus vaccinia responder) stem cells differentiating in a K(d)D(k) chimeric host failed to generate a measurable response to D(k) plus vaccinia. In contrast, stem cells from K(d)D(k) (D(k) plus vaccinia low responders) differentiating in a K(d)D(d) (K(d) and D(d) high responders to vaccinia) host do generate responsiveness to D(d) plus vaccinia. These results indicate that in chimeras, the Ir phenotype is independent of the donor T cell's Ir genotype, and that thymic selection of a T cell's restriction specificity for a particular H-2 allele of the chimeric host also defines that T cell's/r phenotype.  (+info)

Hydroxyapatite-coated femoral stems. Histology and histomorphometry around five components retrieved at post mortem. (6/9035)

We performed a histological and histomorphometric examination in five cadaver specimens of the femoral and acetabular components and the associated tissue which had been recovered between 3.3 and 6.2 years after primary total hip arthroplasty (THA) using a proximal hydroxyapatite (HA)-coated titanium alloy implant. All had functioned well during the patients' life. All the stems were fixed in the femur and showed osseointegration of both the proximal and distal parts. The amount of residual HA was greatest in the distal metaphyseal sections, indicating that the rate of bone remodelling may be the main factor causing loss of HA. The level of activity of the patient was the only clinical factor which correlated with loss of coating. The percentage of bone-implant osseointegration was almost constant, regardless of the amount of HA residue, periprosthetic bone density or the time of implantation. HA debris was seldom observed and if present did not cause any adverse or inflammatory reaction. Partial debonding did occur in one case as a result of a polyethylene-induced inflammatory reaction.  (+info)

Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice. (7/9035)

Mutations that activate the N-ras oncogene are among the most frequently detected genetic alterations in human acute myeloid leukemias (AMLs), Philadelphia chromosome-negative myeloproliferative disorders (MPDs), and myelodysplastic syndromes (MDSs). However, because N-ras has not been shown to induce these disorders in an in vivo model, the role of N-ras in the evolution of myeloid leukemia is unclear. To investigate the potential of N-ras to induce myeloid leukemia, lethally irradiated mice were reconstituted with bone marrow (BM) cells infected with a retroviral vector carrying activated N-ras. Approximately 60% of these mice developed hematopoietic disorders, including severe MPDs resembling human chronic myelogenous leukemia (CML) or AML with differentiation (French-American-British [FAB] classification M2). Other reconstituted mice succumbed to hematopoietic defects that were pathologically similar to human MDSs. The latter disorders appeared to be due to a myeloid impairment that was demonstrated by enumeration of day-12 colony-forming units-spleen (CFU-S) and by in vitro colony assays. A high level of apoptosis associated with thymic atrophy and peripheral blood (PB) lymphopenia was also evident in N-ras reconstituted mice. Our results are consistent with a model in which antiproliferative effects are a primary consequence of N-ras mutations and secondary transforming events are necessary for the development of myeloid leukemia. This is the first report of an in vivo model for N-ras induced MPD and leukemia.  (+info)

Quantitative polymerase chain reaction for the detection of micrometastases in patients with breast cancer. (8/9035)

PURPOSE: Previous reports have indicated that reverse transcriptase polymerase chain reaction (RT-PCR) for cytokeratin 19 (CK-19) may be useful in the management of patients with breast cancer. However, the specificity of this technique is low, principally because of a high rate of false-positive results. To improve the specificity of this assay, we developed a quantitative RT-PCR methodology that enables an estimate to be made of the number of CK-19 transcripts in blood and bone marrow samples. PATIENTS AND METHODS: We examined 45 peripheral-blood samples and 30 bone marrow samples from patients with a variety of nonneoplastic conditions using nested RT-PCR for CK-19. We also examined bone marrow and peripheral-blood samples from 23 patients with primary breast cancer and peripheral-blood samples from 37 patients with metastatic breast cancer. The number of CK-19 transcripts was estimated in positive specimens by competitive PCR and normalized to the number of ABL transcripts as an internal control for the quality and quantity of cDNA. RT-PCR results were compared with the numbers of CK-19-positive cells detected by immunocytochemistry. RESULTS: Analysis of samples from patients without cancer enabled us to define an upper limit for the background ratio of CK-19 to ABL transcripts (1:1,000 for blood samples and 1:1,600 for bone marrow samples). Using these figures as cut-off points, elevated CK-19: ABL ratios were detected in peripheral-blood samples of 20 of 37 (54%) patients with metastatic breast cancer and in bone marrow samples of 14 of 23 (61%) patients with primary breast cancer. Only three of 23 (13%) primary breast cancer peripheral-blood samples and none of the control samples were positive by these criteria. Only two of 23 patients (9%) with primary breast cancer showed immunocytochemically detectable cells in the blood; 10 of 23 (43%) showed immunocytochemically detectable cells in the bone marrow. Of 36 patients with metastatic breast cancer, eight (22%) showed positive events. CONCLUSION: Quantitative RT-PCR for CK-19 detects a percentage of patients with breast cancer and may enable the progression or regression of the disease to be monitored.  (+info)

Biopsy, bone marrow (Bone marrow biopsy) - Tests & ProceduresBiopsy, bone marrow (Bone marrow biopsy) - Tests & Procedures
Bone marrow biopsy and bone marrow aspiration are procedures to collect and examine bone marrow - the spongy tissue inside some of your larger bones. Bone marrow biopsy and bone marrow aspiration can show whether your bone marrow is healthy and making normal amounts of blood cells. Doctors use bone marrow biopsy and aspiration to diagnose and monitor blood and marrow diseases, including some cancers.
Bone marrow - Simple English Wikipedia, the free encyclopediaBone marrow - Simple English Wikipedia, the free encyclopedia
There are two types of bone marrow. Red marrow is made mostly of myeloid tissue (which makes new blood cells). Red blood cells, platelets, and most white blood cells are created by red marrow. Yellow marrow is made mainly of fat cells. Both types of bone marrow contain many blood vessels and capillaries. When a person is born, all of their bone marrow is red. As the person ages, more and more of the bone marrow changes to the yellow type. By adulthood, about half of a persons bone marrow is red. Red marrow is found mainly in the flat bones - like the hip bone, breast bone, skull, ribs, vertebra (the bones that make up the spinal column), and shoulder blades - and in the cancellous ("spongy") material at the ends of the long bones like the femur (thigh bone) and humerus (upper forearm bone). Yellow marrow is found inside the hollow middle section, or medullary cavity of the long bones. In cases of severe blood loss, the body can change yellow marrow back to red marrow so that more blood cells ...
What is Bone Marrow?What is Bone Marrow?
Certain diseases of the bone marrow like leukemia, multiple myeloma, myelodysplastic syndrome (MDS), pancytopenia, anemia etc. require examination of the bone marrow tissue. This is called bone marrow aspiration or bone marrow biopsy. A needle is used to withdraw samples of the marrow from within the bone. This is often a very painful process.. Bone marrow is suppressed with the use of cancer chemotherapy. This leads to severe drop in production of RBCs (leading to anemia), WBCs (leading to increased risk of life threatening infections) and platelets (leading to risk of bleeding tendencies).. With advent of medical science it is possible now to transplant the bone marrow in diseased individuals. This process has shown success in a number of cancer patients.. Reviewed by April Cashin-Garbutt, BA Hons (Cantab). ...
What You Should Know About Bone Marrow Biopsy for the Staging of Lymphoma - UNM Comprehensive Cancer CenterWhat You Should Know About Bone Marrow Biopsy for the Staging of Lymphoma - UNM Comprehensive Cancer Center
Cancers that begin in cells of the lymph system are referred to as malignant lymphomas. The lymph system includes the spleen, thymus, tonsils, bone marrow, lymph nodes and circulating white blood cells called lymphocytes. Lymphocytes and the lymph system are part of the immune system that protects the body from disease and infection. Cancers of the lymph system are referred to as Hodgkins lymphoma or non-Hodgkins lymphoma.. Newly diagnosed lymphoma patients are required to undergo a number of tests and procedures to ensure accurate diagnosis and staging. Tests may include a lymph node biopsy, blood tests, a CT scan, PET scan and bone marrow biopsy. Some patients report that of these, the most difficult is the bone marrow biopsy.. Bone marrow, found in the center of most large bones, is a spongy material that produces red blood cells, white blood cells and platelets. A bone marrow biopsy is used to evaluate how well the bone marrow is functioning and to determine if lymphoma is present. This is ...
Aging | The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile...Aging | The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile...
Purpose: Marrow adipose tissue (MAT) expansion and associated lipotoxicity are important drivers of age-related bone loss and hematopoietic bone marrow (HBM) atrophy. Fish oil and borage oil (rich in ω3 fatty acids) can partially prevent aged-related bone loss in SAMP8 mice. However, whether preservation of bone mass in this progeria model is associated with MAT volumes remains unknown.Results: MAT volume fraction (MAT%) showed a negative association with hematopoietic bone marrow (HBM%;r=-0.836, p<0.001) and bone (bone%;r=-0.344, p=0.013) volume fractions.Adjusting for multiple comparisons, bone% was higher and MAT% was lower in Fish oil (FO)-supplemented groups vs. controls (p<0.001). HBM% did not differ significantly between the four groups. However, in the group supplemented with FO, HBM comprised higher fractions and MAT constituted lower fractions of total marrow vs. controls (p<0.001).Conclusion: Feeding FO-enriched diet prevented age-related bone and HBM loss,
Bone Marrow Collection and ExaminationBone Marrow Collection and Examination
1. Bone marrow is commonly collected and examined when abnormalities are found in the circulating blood. The most common abnormality is a persistent shortage of one of the blood cell types. This is a serious situation and may be due to a problem in the bone marrow. Examination of marrow can often provide information about the underlying cause, and may help to predict the outcome.. 2. Bone marrow is also collected and examined to look for certain types of cancer. Some cancers start right in the cells of the bone marrow and other cancers spread to the bone marrow from elsewhere in the body. Cancer that starts in the bone marrow is sometimes called "leukemia." Examination of the bone marrow helps to identify the cancer, and reveals how seriously the marrow is affected.. 3. Occasionally, bone marrow is collected and examined to investigate other problems such as persistent fever, unexplained weight loss, high blood calcium levels (see article on Hypercalcemia), and high serum protein level (see ...
Bone Marrow</span><span class=w-nav...Bone Marrow</span><span class="w-nav...
The two types of bone marrow are "red marrow" (Latin: medulla ossium rubra), which consists mainly of hematopoietic tissue, and "yellow marrow" (Latin: medulla ossium flava), which is mainly made up of fat cells. Red blood cells, platelets, and most white blood cells arise in red marrow. Both types of bone marrow contain numerous blood vessels and capillaries. At birth, all bone marrow is red. With age, more and more of it is converted to the yellow type; only around half of adult bone marrow is red. Red marrow is found mainly in the flat bones, such as the pelvis, sternum, cranium, ribs, vertebrae and scapulae, and in the cancellous ("spongy") material at the epiphyseal ends of long bones such as the femur and humerus. Yellow marrow is found in the medullary cavity, the hollow interior of the middle portion of short bones. In cases of severe blood loss, the body can convert yellow marrow back to red marrow to increase blood cell production.. ...
About | International Journal of Bone Marrow Research | HSPCAbout | International Journal of Bone Marrow Research | HSPC
Bone marrow is the soft spongy tissue that lies within the hollow interior of long bones. In adults, marrow in large bones produces new blood cells. Bone marrow forms around 4% of total body weight. There are two types of bone marrow: red marrow that is responsible for producing red blood cells, white blood cells and platelets; and yellow marrow consisting mainly of fat cells.. International Journal of Bone Marrow Research publishes rigorously peer-reviewed manuscripts focusing on latest advancements related to all aspects of bone marrow. The manuscripts published in International Journal of Bone Marrow Research seeks to provide valuable information in bone marrow research, related diseases, transplant procedure and all aspects of follow-up care.. ...
Bone Marrow Biopsy for DogsBone Marrow Biopsy for Dogs
The bone marrow biopsy will be done using a needle (biopsy needle), which will be introduced in a bone (typically the backbone or ribs, as these contain more marrow matter). However, if the dog is suspected of having bone cancer localized in certain areas, the vet will insert the needle in the affected bone. Bone marrow biopsies can be performed in the hip bones, shoulders or thigh bones. Using the needle, the vet will extract a bit of bone marrow fluid. The needle is gently extracted and the fluid will be taken for testing. The vet may perform the analysis or he may choose to send the bone marrow sample to a pathologist. The procedure may take up to 30 minutes, depending on the bone that is being analyzed. ...
Bone marrow - definition of bone marrow by The Free DictionaryBone marrow - definition of bone marrow by The Free Dictionary
Define bone marrow. bone marrow synonyms, bone marrow pronunciation, bone marrow translation, English dictionary definition of bone marrow. n. The soft tissue that fills most bone cavities and consists of yellowish fatty tissue or reddish vascular tissue. In adult mammals, the bone marrow of...
Regulation of Bone Marrow Angiogenesis by Osteoblasts during Bone Development and Homeostasis | Scholars@DukeRegulation of Bone Marrow Angiogenesis by Osteoblasts during Bone Development and Homeostasis | [email protected]
Regulation of Bone Marrow Angiogenesis by Osteoblasts during Bone Development and Homeostasiss profile, publications, research topics, and co-authors
Patent US8096957 - Method for removing material from a patients body - Google PatentsPatent US8096957 - Method for removing material from a patient's body - Google Patents
The invention comprises a method for removal of bone marrow tissue from a patients body. The method generally comprises the steps of providing an apparatus comprising an elongate member for receiving bone marrow tissue. The elongate member defines a lumen and comprises a distal end defining an aperture and a proximal end. The apparatus further comprises an elongate tissue removal member for conveying bone marrow tissue through the lumen. The tissue removal member is rotatably disposed within the lumen. The method further comprises gathering a sample of said tissue into said lumen; and conveying with said tissue removal member at least a portion of the tissue sample proximally along said lumen. The step of gathering may be accomplished by advancing the apparatus through the tissue.
Use of Bone Marrow Concentrate for Treatment of Alar, Accessory, and Transverse Ligament Injuries - Full Text View -...Use of Bone Marrow Concentrate for Treatment of Alar, Accessory, and Transverse Ligament Injuries - Full Text View -...
This study will be a single-center, prospective, single-blinded, randomized, controlled study of patients with CCJ instability that are randomized to either bone marrow concentrate (BMC) treatment or a sham procedure to evaluate the safety and effectiveness of using an anterior approach through the posterior oropharynx for treating alar and transverse ligament injuries. Patients will undergo a bone marrow aspiration of approximately 30-60 cc from the posterior superior iliac crest. Platelet rich plasma (PRP) and platelet lysate (PL) will be derived from the bone marrow aspirate and later mixed with the bone marrow nucleated cell layer for those in the treatment group. While under unconscious TIVA anesthesia, the injectate is then injected under fluoroscopy into the area in need of treatment using an anterior approach through the posterior oropharynx with direct visualization of the injection site via endoscopy. Patients assigned to the sham control condition will also undergo a bone marrow ...
Characterization of NKR+ T-cell subsets in human bone marrow: implications for immunosurveillance of neoplasia<...Characterization of NKR+ T-cell subsets in human bone marrow: implications for immunosurveillance of neoplasia<...
TY - JOUR. T1 - Characterization of NKR+ T-cell subsets in human bone marrow. T2 - implications for immunosurveillance of neoplasia. AU - Dean, J. AU - McCarthy, D. AU - Doherty, D G. AU - OFarrelly, C. AU - Golden-Mason, L. AU - Lawler, Mark. PY - 2005/1. Y1 - 2005/1. N2 - In addition to hematopoietic progenitors, human bone marrow contains mature T/NK lymphocytes. Valpha24Vbeta11 NKT-cells, a subset of NK receptor+ (NKR+) T-cells in humans, are rare in bone marrow, suggesting the presence of other NKR+ T-cells which may contribute to tumor surveillance. NKR+/- T-cells were examined in blood (PB), and bone marrow from donors (DM) and patients with active hematopoietic malignancy (PM), or in remission (PR). T-cells in PR & PM were enriched for CD56+ and CD57+ subsets, compared to DM. All marrow NKR+/- T-cell subsets were more activated than PB. PM and, surprisingly, PR marrow contained more activated cells than DM. CD8+ cells were significantly increased in all patient marrows and there was ...
PET/CT versus bone marrow biopsy in the initial evaluation of bone marrow infiltration in various pediatric malignanciesPET/CT versus bone marrow biopsy in the initial evaluation of bone marrow infiltration in various pediatric malignancies
PET-CT has a high sensitivity when assessing marrow infiltration in pediatric malignancies. Advances in radiologic modalities may obviate the use of invasive, painful, and costly procedures like BMB. Furthermore, biopsy results are limited by insufficient tissue or the degree of marrow infiltration …
All You Need To Know About Bone Marrow | Facts About Bone Marrow| HPAll You Need To Know About Bone Marrow | Facts About Bone Marrow| HP
All You Need To Know About Bone Marrow, Facts About Bone Marrow, Health Pick, Bone Marrow Transplant, Myths and facts about bone marrow, Bone Marrow Cancers
Frontiers | Exercise Regulation of Marrow Adipose Tissue | EndocrinologyFrontiers | Exercise Regulation of Marrow Adipose Tissue | Endocrinology
Despite association with low bone density and skeletal fractures, marrow adipose tissue (MAT) remains poorly understood. The marrow adipocyte originates from the mesenchymal stem cell pool (MSC) that gives rise also to osteoblasts, chondrocytes, and myocytes among other cell types. To date, the presence of MAT has been attributed to preferential biasing of MSC into the adipocyte rather than osteoblast lineage, thus negatively impacting bone formation. Here we focus on understanding the physiology of MAT in the setting of exercise, dietary interventions and pharmacologic agents that alter fat metabolism. The beneficial effect of exercise on musculoskeletal strength is known: exercise induces bone formation, encourages growth of skeletally-supportive tissues, inhibits bone resorption and alters skeletal architecture through direct and indirect effects on a multiplicity of cells involved in skeletal adaptation. MAT is less well studied due to the lack of reproducible quantification techniques. In recent
Bone Marrow Transplant for Children | Phoenix Childrens HospitalBone Marrow Transplant for Children | Phoenix Children's Hospital
Once suitable stem cells are found, your child will receive high doses of chemotherapy or radiation (sometimes both) to destroy existing bone marrow. This gives the new bone marrow cells room to grow. This may be called ablative or myeloablative therapy. It stops new blood cells from being made. The bone marrow becomes empty. An empty marrow is needed to make room for the new stem cells to grow and create a new system to make new blood cells. Next, stem cells are given to your child through an IV in a large vein, often in the chest. This is called a central venous catheter. Getting the stem cells is like having a blood transfusion. The stem cells find their way into the bone marrow. They begin growing and making new, healthy blood cells. During infusion of the bone marrow, your child may have:. ...
Bone Marrow may be the Missing Piece of the Fertility Puzzle: StudyBone Marrow may be the Missing Piece of the Fertility Puzzle: Study
When an egg is fertilized, stem cells leave the bone marrow and travel via the bloodstream to the uterus, where they help transform the uterine lining for implantation.
Safety and Efficacy Study of Autologous Concentrated Bone Marrow Aspirate (cBMA) for Critical Limb Ischemia (CLI) - Full Text...Safety and Efficacy Study of Autologous Concentrated Bone Marrow Aspirate (cBMA) for Critical Limb Ischemia (CLI) - Full Text...
This is a prospective, randomized, double-blind, placebo controlled, multicenter trial intended for subjects with critical limb ischemia (CLI) that are unsuitable for revascularization. The investigational treatment utilizes autologous concentrated bone marrow aspirate (cBMA) at the point of care. The bone marrow aspirate is obtained from the subjects hip, concentrated with a bone marrow concentration device, and delivered intramuscularly to the affected limb. Subjects meeting the inclusion/exclusion criteria will be randomized to receive either the investigational treatment (cBMA) or a placebo control (sham treatment ...
Bilateral Trephine Bone Marrow Biopsies in Lymphoma and Other Neoplastic Diseases | Annals of Internal Medicine | American...Bilateral Trephine Bone Marrow Biopsies in Lymphoma and Other Neoplastic Diseases | Annals of Internal Medicine | American...
We have evaluated the usefulness of bilateral rather than unilateral posterior iliac spine trephine biopsies in searching for lymphoma and other neoplastic diseases in the bone marrow. Two hundred and eighty-two patients with these diseases were studied. Tumor was found on only one side in 22% of patients with non-Hodgkins malignant lymphoma, in 43% of patients with Hodgkins disease, and in 36% of patients with other neoplastic processes. Thus, the second biopsy yields an additional 11% to 22% of positive biopsies. We conclude that bilateral trephine bone marrow biopsies should be routinely performed when searching for tumor in the bone marrow. ...
Identification of CD22 Ligands on Bone Marrow Sinusoidal Endothelium Implicated in CD22-dependent Homing of Recirculating B...Identification of CD22 Ligands on Bone Marrow Sinusoidal Endothelium Implicated in CD22-dependent Homing of Recirculating B...
Here we present evidence that CD22 is a specific receptor involved in the homing of long-lived recirculating B cells to the bone marrow. Our demonstration that CD22 ligands are constitutively expressed on endothelial cells in the bone marrow, but not in other organs, raises the attractive possibility that CD22 can function as a classical homing receptor for the bone marrow by targeting cells to the appropriate microenvironment. It has been reported that IgD+ recirculating cells are found in the extravascular space, mainly in perisinusoidal locations ((15)). The interaction with CD22 ligands on endothelial cells could be an important first step before transmigration of B cells into the bone marrow parenchyma. Another possibility is that CD22 serves as a retention signal, preventing the reexit of B cells from the bone marrow.. The reason for the incomplete block in B cell homing after the in vivo treatments could be related to the relatively low affinity of the carbohydrate binding region of CD22 ...
Bone Marrow Biopsy. To Prepare - PDF Descargar libreBone Marrow Biopsy. To Prepare - PDF Descargar libre
Bone Marrow Biopsy Bone marrow is the soft tissue inside your bones where blood cells are made. During a bone marrow biopsy, a small tissue sample is taken and sent for tests. The biopsy is often taken
Bone Marrow AspirationBone Marrow Aspiration
Bone marrow aspirate concentrate (BMAC) is an FDA-approved, non-embryonic stem cell treatment in which the bodys stem cells are used to spur tissue regeneration and hasten healing.. Harvested from the patients own bone marrow, these regenerative cells are injected into the injury site in the same manner as platelet rich plasma (PRP). During BMAC, your orthopaedic surgeon extracts bone marrow from the hip or pelvic bone. Spinning the marrow in a centrifuge, he or she separates the regenerative stem cells and injects them into the painful site. After just two to three weeks, patients experience increased joint and muscle stability and may pursue physical therapy to strengthen the problem area.. ...
Bone Marrow Biopsy and AspirationBone Marrow Biopsy and Aspiration
Bone marrow biopsy and bone marrow aspiration are procedures to collect and examine bone marrow - the spongy tissue inside some of your larger bones.
Comparison of cultured mesenchymal stem cells derived from bone marrow or peripheral blood of ratsComparison of cultured mesenchymal stem cells derived from bone marrow or peripheral blood of rats
Objectives: Mesenchymal stem cells (MSC) are primarily isolated from bone marrow. Peripheral blood is also reported as an alternative source of MSC. This study compared MSC which were isolated and cultured from bone marrow and those from peripheral blood of rats. Methods: MSC from bone marrow and peripheral blood were harvested from 5 male Sprague Dawley rats. After isolation, the cells were grown on tissue culture plates with concentration of 107 cells per well. Observations were conducted to evaluate the attachment of nucleated cells with fibroblast-like morphology. Characterization of MSC was done using reverse transcriptase-polymerase chain reaction (RT-PCR) and immunocytochemistry assay. Results: The mean number of nucleated cells isolated from the bone marrow on day 0 was higher than those isolated from the peripheral blood. Bone marrow MSC with typical fibroblast-like morphology proliferated rapidly and reached 80% confluency on day 14. Subcultures were able to be conducted on day 15 ...
LEARN: How Bone Marrow Transplants Work - NegosentroLEARN: How Bone Marrow Transplants Work - Negosentro
The typical procedure will start with a course of very high doses of chemotherapy, specifically tailored to obliterate the patients existing bone marrow. This procedure is called myeloablation, and is meant to kill the diseased bone marrow and affected blood cells. At this point, because of the lack of bone marrow and the cells that comprise it, including the immune cells, the patient becomes very susceptible to infection. This actually is the major cause of death and disability for HSCT.. After a few days, the hematopoietic stem cells, which are the stem cells that will become the patients new bone marrow, are given to the patient. Depending on the disease, this could be from the patients own stem cells, or from a matched donor. And once these have been implanted, they then start to function as the new bone marrow with potentially curative results.. The success rates for HSCT differ and would depend on a lot of factors, some are inherent in the patient, biology of the disease and facilities ...
Bone Marrow biopsy - processing - ppt video online downloadBone Marrow biopsy - processing - ppt video online download
Introduction Examination of the bone marrow (BM) aspirate and trephine biopsy is essential for the diagnosis of BM disorders. A comprehensive diagnosis of a BM disorder often requires the integration of various diagnostic approaches: peripheral blood (PB) counts and smear evaluation, BM aspirate and imprint smear, BM trephine biopsy Other investigations such as cytochemistry, immunophenotypic analysis, cytogenetic and molecular genetic techniques, Biochemical and microbiological test results, as appropriate. The aspirate and trephine biopsy provide complementary and useful information. It is recommended that both BM aspirate and biopsy be routinely performed so that respective findings can be correlated.
Bone Marrow Protein May be Target for Improving Stem Cell TransplantsBone Marrow Protein May be Target for Improving Stem Cell Transplants
Bone marrow contains hematopoietic stem cells, the precursors to every blood cell type. These cells spring into action following bone marrow transplants, bone marrow injury and during
Bone Marrow BiopsyBone Marrow Biopsy
A bone marrow biopsy involves removing a small sample of the bone marrow inside your bones for testing. Bone marrow is a soft tissue in the center of most large bones. It makes most of the bodys blood cells. The biopsy is done using a small needle inserted into the bone
The humoral immune response of mouse bone marrow lymphocytes in vitro. by J Ryser and R W. Dutton"The humoral immune response of mouse bone marrow lymphocytes in vitro." by J Ryser and R W. Dutton
Ryser, J and Dutton, R W., "The humoral immune response of mouse bone marrow lymphocytes in vitro." (1977). Subject Strain Bibliography 1977. 3265 ...
In situ detection of CD73+ CD90+ CD105+ lineage: Mesenchymal stromal cells in human placenta and bone marrow specimens by...In situ detection of CD73+ CD90+ CD105+ lineage: Mesenchymal stromal cells in human placenta and bone marrow specimens by...
In situ detection of CD73+ CD90+ CD105+ lineage: Mesenchymal stromal cells in human placenta and bone marrow specimens by chipcytometry2018-09-262018-09-26http://www.zellkraftwerk.com/wp-content/uploads/2014/09/zkw_logo.jpgZELLKRAFTWERKhttp://www.zellkraftwerk.com/wp-content/uploads/2014/09/zkw_logo.jpg200px200px ...
Low bone marrow volume -Doctors Lounge(TM)Low bone marrow volume -Doctors Lounge(TM)
I have a sister who has been sick for a while, gradually getting worse. Over the last year she has lost a TON of hair, she has joint pains, shortness of breath, and very tired. She got blood work at her doctors office and he said she was very anemic and that there were some abnormal cells and he wanted her to go to a hematologist. She did. They took more blood and did a test for lupus and RA and those 2 tests were essentially negative but she was even more anemic, so they wanted to do a bone marrow biopsy. When they did the bone marrow, they did not get enough marrow to test but the bone biopsy showed caseating granulomas. They just did another bone marrow aspiration yesterday to test that and they had a real hard time getting anything to aspirate. They mentioned dust a few times.?? The pathologist said they got enough though for the doctor to make the diagnosis and that he was leaning towards 2 different things but could not say what. It will be another week before we hear anything from the ...
Methods of Isolating and Using Enriched Subpopulations of Bone Marrow Progenitors for the Treatment of Diabetes - Patent...Methods of Isolating and Using Enriched Subpopulations of Bone Marrow Progenitors for the Treatment of Diabetes - Patent...
0031]The population of bone marrow cells from which the subpopulation is enriched may be combined with and stained by the fluorescing substrate, precursor, or analog thereof in any manner known to those skilled in the art. Typically, the population of bone marrow cells may be incubated with the same for a period of about 1 to 60 minutes prior to being subjected to the methods of determining internal fluorescence and orthogonal light scatter of the cells contained therein. Preferably, the protocol is one that is consistent with the use of the Aldefluor® kit, with slight modifications to identify and isolate the ALDHloSSClo progenitors. Briefly, control and test samples of a bone marrow or bone marrow derived cell sample are created. An aliquot of diethylaminobenzaldehyde (DEAB) is added to the control sample test tube and an aliquot of DMSO-activated Aldefluor® substrate is added to the test sample test tube. An aliquot of the test sample is then immediately combined with the control sample in ...
Bone marrow biopsy | Cancer Survivors NetworkBone marrow biopsy | Cancer Survivors Network
Hello. I am seeking information on bone marrow biopsy for my mom. She is going on 84 yrs old and is in a weakened state due to a colon resection mistake that eventually led into septic shock.. Long story make short, she endured much to correct the procedure and survived-something they didnt expect-yet she is not the same. Although,considering what she endured, doing miraculously well, thank God.. Her hemo/oncol wants to do a bone marrow biopsy to rule out multiple myeloma. Im nervous about it. Ptsd from what happened to her 2 yrs ago acter her colon cancer eradication and the chain of events that happened afterwards.. Ive tried to do research on elderly with frailities, and other conditions to see if it is common and safe for them to undergo tbe procedure. Little to no info out there. Can anyone help with knowledge and/or experience in this area? ...
PAXgene Bone Marrow RNA Kit | PreAnalytiXPAXgene Bone Marrow RNA Kit | PreAnalytiX
For purification of intracellular RNA from bone marrow samples in PAXgene Bone Marrow RNA Tubes To be used in conjunction with the PAXgene Bone Marrow RNA Tube Rapid purification of RNA with high integrity and purity Optimized protocol for heterogeneous bone marrow samples Integrated DNase treatment for gDNA removal
Bone Marrow Biopsy video: Day 3 of Chemo | Bone Marrow Biopsy Vlog #4Bone Marrow Biopsy video: Day 3 of Chemo | Bone Marrow Biopsy Vlog #4
My husband just had his 20 something bone marrow biopsy to check how many leukemia cells are in his bones, There are 4 of us in the room talking to keep him distracted because its extremely painful ...
Bone Marrow Biopsy video: Bone Marrow BiopsyBone Marrow Biopsy video: Bone Marrow Biopsy
My husband just had his 20 something bone marrow biopsy to check how many leukemia cells are in his bones, There are 4 of us in the room talking to keep him distracted because its extremely painful ...
Selective exposure of bone marrow lymphocytes to massive doses of hydrocortisone for the purpose of facilitating the...Selective exposure of bone marrow lymphocytes to massive doses of hydrocortisone for the purpose of facilitating the...
Semantic Scholar extracted view of [Selective exposure of bone marrow lymphocytes to massive doses of hydrocortisone for the purpose of facilitating the ultrastructural identification of hematopoietic stem cells]. by Z. A. Butenko et al.
Regenestem Training - Bone MarrowRegenestem Training - Bone Marrow
Bone Marrow. This one full day hands one course offers the knowledge and skills necessary to perform a bone marrow harvesting, processing, and activation procedure. It comprises a 2 hour theoretical presentation and two practical cases.. Target Audience: Physicians, nurses and physician assistants. Goals and objectives:. Discuss the different points of access to obtain bone marrow aspirate and the anatomical markings. Familiarize the attendee with biological understanding of hematopoietic and mesenchimal Regenestem derived from bone marrow. Familiarize the attendee with latest literature to support the protocols of treatments. To provide the attendee with the abilities to perform the protocols provided in the class.. ...
Bone marrows synonyms, bone marrows antonyms - FreeThesaurus.comBone marrows synonyms, bone marrows antonyms - FreeThesaurus.com
Synonyms for bone marrows in Free Thesaurus. Antonyms for bone marrows. 47 synonyms for marrow: core, heart, spirit, quick, soul, cream, substance, essence, kernel, gist, pith, quintessence, core, essence, gist, heart, kernel, meat. What are synonyms for bone marrows?
Bone Marrow Characteristics Associated With Changes in Infarct Size After STEMINovelty and Significance | Circulation ResearchBone Marrow Characteristics Associated With Changes in Infarct Size After STEMINovelty and Significance | Circulation Research
The purpose of this exploratory study was to identify patterns in BMC characteristics associated with either an increase or a decrease in infarct size in patients with STEMI. To accomplish this, we analyzed data from patients in the CCTRN TIME trial who provided consent to have their BMC product analyzed by the CCTRN Biorepository laboratories. Multivariable regression analysis showed that an increased percentage of CD31+ cells in the bone marrow was associated with a greater reduction in infarct size at 6 months after STEMI. In addition, a greater reduction in infarct size was associated with a faster BMC growth rate in CFU-Hill and ECFC functional assays. Thus, our findings suggest that phenotype and functional assessments of bone marrow may be important for understanding individual responses to cell therapy in patients with acute STEMI. In addition, they may provide a means to prognosticate outcomes after STEMI and to evaluate the mechanisms underlying responses to myocardial injury.. CD31 ...
Redox regulation of stem/progenitor cells and bone marrow niche<...Redox regulation of stem/progenitor cells and bone marrow niche<...
TY - JOUR. T1 - Redox regulation of stem/progenitor cells and bone marrow niche. AU - Urao, Norifumi. AU - Ushio-Fukai, Masuko. N1 - Funding Information: This work was supported by funds from the National Institutes of Health (R01 Heart and Lung (HL) 077524 and HL077524-S1 to M.U.-F.), American Heart Association (AHA) National Center Research Program Innovative Research Grant 0970336N (to M.U.-F), AHA Post-doctoral Fellowship 09POST2250151 (to N.U.), and AHA Scientist Development Grant 12SDG12060100 (to N.U.). PY - 2013/1. Y1 - 2013/1. N2 - Bone marrow (BM)-derived stem and progenitor cell functions including self-renewal, differentiation, survival, migration, proliferation, and mobilization are regulated by unique cell-intrinsic and -extrinsic signals provided by their microenvironment, also termed the niche. Reactive oxygen species (ROS), especially hydrogen peroxide (H2O2), play important roles in regulating stem and progenitor cell functions in various physiologic and pathologic responses. ...
Human Bone Marrow Derived Stem Cell Culture Extra-cellular Expansion Matrix pre-coated 48 Well Plate |CelprogenHuman Bone Marrow Derived Stem Cell Culture Extra-cellular Expansion Matrix pre-coated 48 Well Plate |Celprogen
Human Bone Marrow Derived Stem Cell Culture Extra-cellular Expansion Matrix is essential for Expansion of Human Bone Marrow Derived Stem Cell Cultures. This product requires Human Bone Marrow Derived Stem Cell Culture Media Cat#M36093-20 and Cells Cat# 36093-20. Also available Products ...
Download PDF Bone marrow biopsy by Stephan Ignaz Leitner EbookDownload PDF Bone marrow biopsy by Stephan Ignaz Leitner Ebook
Introduction. The bone marrow biopsy and aspiration (BMBA) is an essential diagnostic approach to the diagnosis of hematological disorders [].It was developed in the beginning of the nineteenth century, allowing doctors to diagnose marrow disorders in patients [16, 33].The procedure evolved in the following years with focus on easier and repeatable collection of bone marrow, leading Cited by:
Acute Lymphocytic Leukemia (ALL): DiagnosisAcute Lymphocytic Leukemia (ALL): Diagnosis
This procedure is done by taking out small amounts of bone marrow. Bone marrow samples are usually taken from the back of the hip (pelvic) bone. For the bone marrow aspiration, the area over the hip is numbed. A thin, hollow needle is inserted through the skin and into the hip bone. A syringe is used to pull out a small amount of liquid bone marrow. You may have some brief pain when the marrow is removed. A bone marrow biopsy is usually done just after the aspiration. A small piece of bone and marrow is removed with a slightly larger needle that is pushed down into the bone. The biopsy may also cause some brief pain. The bone marrow is then checked for leukemia cells and tested in various ways (see below).. ...
Bone marrow biopsyBone marrow biopsy
A bone marrow biopsy is the removal of marrow from inside bone. Bone marrow is the soft tissue inside bones that helps form blood cells. Learn more here.
DNA, Bone Marrow and FrostingDNA, Bone Marrow and Frosting
In 2003, when I first found out that I was pregnant with #3, I was in total shock! Two kids seemed just right and really, how in the world could a 40 year old be pregnant? (No need to answer, I finally figured it out.) I accepted reality and trusted that God had a great plan in place. I quickly fell madly in love with "Baby E". After Nicolas birth, we realized that our family of 5 was perfect! We refer to Nicolas as "the frosting on our cake". This morning, I received a patient family report for bone marrow transplant which, after blood draws, shows which family member would be the best bone marrow donor. They gather this information early on in the event a bone marrow transplant is needed. Ive believed that God has a special plan for my kids. Presently, it is looking like God has a great purpose for Nicolas as Nicolas bone marrow would be the best match for Emilie. When things seem crazy and out of control, God is always in control and has a purpose and plan for everything. Im blown away by ...
Bone marrow examination - WikipediaBone marrow examination - Wikipedia
Bone marrow examination refers to the pathologic analysis of samples of bone marrow obtained by bone marrow biopsy (often called a trephine biopsy) and bone marrow aspiration. Bone marrow examination is used in the diagnosis of a number of conditions, including leukemia, multiple myeloma, lymphoma, anemia, and pancytopenia. The bone marrow produces the cellular elements of the blood, including platelets, red blood cells and white blood cells. While much information can be gleaned by testing the blood itself (drawn from a vein by phlebotomy), it is sometimes necessary to examine the source of the blood cells in the bone marrow to obtain more information on hematopoiesis; this is the role of bone marrow aspiration and biopsy. Bone marrow samples can be obtained by aspiration and trephine biopsy. Sometimes, a bone marrow examination will include both an aspirate and a biopsy. The aspirate yields semi-liquid bone marrow, which can be examined by a pathologist under a light microscope and analyzed by ...
Bone marrow aplasia and Ewings sarcoma occuring prior to stem cell transplant<...Bone marrow aplasia and Ewing's sarcoma occuring prior to stem cell transplant<...
TY - JOUR. T1 - Bone marrow aplasia and Ewings sarcoma occuring prior to stem cell transplant. AU - Wolff, Lawrence. AU - Moore, T. B.. AU - Magenis, E.. PY - 1999/2. Y1 - 1999/2. N2 - The association of secondary malignancies with bone marrow aplasia after bone marrow transplant is a known entity. We report a 19 year old man who was diagnosed as having bone marrow aplasia. The initial and subsequent evaluations of his bone marrow and blood showed normal chromosomes, normal mitocycin C stimulation, and normal serum acid hemolysis test. In March, 1995, he was treated with antilymphocyte globulin (ALG), cyclosporine (CSA), glucocorticosteroids (G) and gmcsf. His marrow quickly showed trilineage recovery. However by February, 1996, his peripheral blood counts and bone marrow again indicated marrow failure. The very hypocellular marrow showed only a rare CD34 positive cell and the marrow lymphocytes were entirely T suppressor cells (CD3, CD8). Again the bone marrow responded to ALG, CSA, G, and ...
Bone marrow suppression - WikipediaBone marrow suppression - Wikipedia
Bone marrow suppression also known as myelotoxicity or myelosuppression, is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes). Bone marrow suppression is a serious side effect of chemotherapy and certain drugs affecting the immune system such as azathioprine. The risk is especially high in cytotoxic chemotherapy for leukemia. Nonsteroidal anti-inflammatory drugs (NSAIDs), in some rare instances, may also cause bone marrow suppression. The decrease in blood cell counts does not occur right at the start of chemotherapy because the drugs do not destroy the cells already in the bloodstream (these are not dividing rapidly). Instead, the drugs affect new blood cells that are being made by the bone marrow. When myelosuppression is severe, it is called myeloablation. Many other drugs including common antibiotics may cause bone marrow suppression. Unlike chemotherapy the ...
About Bone Marrow Stem Cell TransplantAbout Bone Marrow Stem Cell Transplant
Bone marrow transplant (BMT) can strengthen the body to fight cancer by replacing the blood building cells in the body that are destroyed by chemotherapy and radiation treatments, which are used to kill the cancer cells, with healthy stem cells found in bone marrow.. In a bone marrow transplant, the patients diseased bone marrow is destroyed and healthy bone marrow stem cells are infused into the patients blood-stream. In a successful BMT transplant, the new bone marrow migrates to the cavities of the large bones and begins producing healthy, normal blood cells.. Types of Bone Marrow Transplants. There are several types of bone marrow transplants, also referred to as stem-cell transplants. Which type is used for any given patient depends on the specific patients disease as well as other factors such as the patients age and the availability of a suitable donor. Learn more ,,. Resources. Here at Winship Cancer Institute Bone Marrow Transplant Center we believe patient information is a vital ...
Enhancement of bone marrow allografts from nude mice into mismatched recipients by T cells void of graft-versus-host activity ...Enhancement of bone marrow allografts from nude mice into mismatched recipients by T cells void of graft-versus-host activity ...
Transplantation of 8 x 10(6) C57BL/6-Nu+/Nu+ (nude) bone marrow cells into C3H/HeJ recipients after conditioning with 8 Gy of total body irradiation has resulted in a markedly higher rate of graft rejection or graft failure compared to that found in recipients of normal C57BL/6 or C57BL/6-Bg+/Bg+ (beige) T-cell-depleted bone marrow. Mixing experiments using different numbers of nude bone marrow cells with or without mature thymocytes (unagglutinated by peanut agglutinin) revealed that engraftment of allogeneic T-cell-depleted bone marrow is T-cell dependent. To ensure engraftment, a large inoculum of nude bone marrow must be supplemented with a trace number of donor T cells, whereas a small bone marrow dose from nude donors requires a much larger number of T cells for engraftment. Marked enhancement of donor type chimerism was also found when F1 thymocytes were added to nude bone marrow cells, indicating that the enhancement of bone marrow engraftment by T cells is not only mediated by ...
Bone Marrow Aspiration and Biopsy: The TestBone Marrow Aspiration and Biopsy: The Test
Explains how bone marrow aspiration and biopsy tests are used, when bone marrow aspiration and/or biopsy tests are ordered, and what the results of a bone marrow aspiration or biopsy might mean
Bone Marrow Aspiration and BiopsyBone Marrow Aspiration and Biopsy
Explains how bone marrow aspiration and biopsy tests are used, when bone marrow aspiration and/or biopsy tests are ordered, and what the results of a bone marrow aspiration or biopsy might mean
Bone marrow aspiration and biopsy - Canadian Cancer SocietyBone marrow aspiration and biopsy - Canadian Cancer Society
A bone marrow aspiration and biopsy are usually done together to see how the bone marrow is working. Learn about bone marrow aspiration and biopsy.
Bone Marrow AspirationBone Marrow Aspiration
... is the removal of a small amount of the liquid portion of the bone marrow through a needle inserted into the bone. It can be done to collect bone marrow for stem cell transplantation or chromosomal analysis, or to monitor treatment for certain types of blood disorders.. The bone marrow sample is examined under a microscope to obtain information to:. ...
Bone Marrow Transplant - Swarovski SparklesBone Marrow Transplant - Swarovski Sparkles
For some patients, bone marrow transplants become necessary because of several reasons. It could be because of some severe blood disorders including certain types of blood cancers like leukemia and lymphoma. Further, many people have to go in for high-dose chemotherapy. These high dosages may be quite effective in getting rid of dangerous cancer cells. However, they also wipe out healthy cells and in many cases, the entire bone marrow is wiped out and destroyed. In such situations, the only option is to go in for a bone marrow transplant. When a person needs high dosage chemotherapy, often doctors go in for bone marrow transplant to replace the destroyed bone marrow with new ones. This will help the patients to ensure that after the therapy, the body gets high quality and fresh bone marrow. The same can be used for the production of high-quality blood stem cells from the blood cancer bone marrow transplant. This will help in augmenting the supply of red blood cells, white blood cells, and ...
Antiendothelial cell antibodies induce apoptosis of bone marrow endothelial progenitors in systemic sclerosis.Antiendothelial cell antibodies induce apoptosis of bone marrow endothelial progenitors in systemic sclerosis.
OBJECTIVE: Patients with systemic sclerosis (SSc) have significantly fewer and functionally impaired endothelial progenitor cells (EPC) in peripheral blood and bone marrow; further, endothelial apoptosis seems to play a primary role in the pathogenesis of vascular damage. We investigated whether the failure of bone marrow EPC is related to their apoptotic phenotype and analyzed the possible mechanisms inducing apoptosis.METHODS: The presence of apoptotic cells was investigated in bone marrow aspirates taken from patients with SSc; microvessel density (MVD) and the immunohistochemical expression of vascular endothelial growth factor (VEGF) were also measured in bone marrow biopsies. A correlation between EPC apoptosis and the presence of antiendothelial cell antibodies (AECA) was also investigated.RESULTS: We confirmed the presence of bone marrow EPC dysfunction in SSc, while hematopoiesis was not impaired. Bone marrow studies showed a high percentage of apoptotic progenitors, no signs of ...
Blood and Bone Marrow Transplantation - Guide to Internet Resources for Cancer - CancerIndexBlood and Bone Marrow Transplantation - Guide to Internet Resources for Cancer - CancerIndex
There are many different types of blood cell, but they all develop from stem cells. Most of these stem cells are found in the bone marrow (the soft inside part of the bone), although some are found in the blood (peripheral blood stem cells). Chemotherapy and/or radiotherapy damages normal cells as well as cancer cells. At high doses the bone marrow may be damaged or destroyed, and the patient may not be able to produce the necessary blood cells. In a Bone marrow transplant (BMT), marrow containing healthy stem cells is infused to replace those damaged by the high dose therapy, so that the patient can produce blood cells again. If it is not possible to use marrow, a peripheral blood stem cell transplant (PBSCT) may be given. There are 3 types of transplant: (1) Allogenic transplants are where marrow is donated by another person; (2) Autologous transplants involve cells being taken from the patient, stored, and then reinfused following high-dose therapy; and (3) Syngenic transplants are where the ...
NewYork-Presbyterian Queens - Bone Marrow TransplantNewYork-Presbyterian Queens - Bone Marrow Transplant
About Stem Cell Transplantations (SCT). In the bone marrow, there is approximately one stem cell in every 100,000 blood cells. The bone marrow in the breast bone, skull, hips, ribs, and spine contains the stem cells.. In the blood stream, the number of stem cells is about 1/100 of that in the bone marrow. Transplantation of these stem cells from the blood stream is sometimes used in addition to, or instead of, traditional bone marrow transplantation.. Peripheral blood stem cell transplantation differs from traditional bone marrow transplantation only in the method by which the stem cells are harvested for infusion into the patient.. Harvesting stem cells from bone marrow requires a surgical procedure.. Harvesting stem cells from the blood stream is accomplished by a process called apheresis.. The patient is connected to a cell separation machine via a needle in each arm. Blood is taken from one arm, circulated through the machine to remove the stem cells, and the remaining blood cells are ...
NewYork-Presbyterian Queens - Bone Marrow TransplantNewYork-Presbyterian Queens - Bone Marrow Transplant
About Stem Cell Transplantations (SCT). In the bone marrow, there is approximately one stem cell in every 100,000 blood cells. The bone marrow in the breast bone, skull, hips, ribs, and spine contains the stem cells.. In the blood stream, the number of stem cells is about 1/100 of that in the bone marrow. Transplantation of these stem cells from the blood stream is sometimes used in addition to, or instead of, traditional bone marrow transplantation.. Peripheral blood stem cell transplantation differs from traditional bone marrow transplantation only in the method by which the stem cells are harvested for infusion into the patient.. Harvesting stem cells from bone marrow requires a surgical procedure.. Harvesting stem cells from the blood stream is accomplished by a process called apheresis.. The patient is connected to a cell separation machine via a needle in each arm. Blood is taken from one arm, circulated through the machine to remove the stem cells, and the remaining blood cells are ...
Bone Marrow and Stem Cell Transplant Program UNM …Bone Marrow and Stem Cell Transplant Program UNM …
The Bone Marrow and Stem Cell Transplant Center at the UNM Comprehensive Cancer Center offers treatment choices for people with lymphoma and myeloma.Almost 1,000 New Mexicans receive a blood cancer diagnosis each year, according to American Cancer Society estimates.. The UNM Comprehensive Cancer Center program is the states only bone marrow transplant program.It includes a nurse manager, nurse coordinator, a social worker, a pharmacist, infusion nurses, and an inpatient team. Bone marrow transplantation needs a multidisciplinary team because of the complexity in coordinating care, says Fero. The teams Nurse Manager, Maria Limanovich, says the team follows each person from the beginning of bone marrow transplant treatment through completion.. Bone marrow, the soft reddish material that fills the inside of our bones, produces millions of new blood cells each second. These millions of cells come from a tiny number of bone marrow stem cells. These stem cells are special because they can mature into ...
BONE MARROW ABONRMALITIES IN HIV INFECTION | Mediterranean Journal of Hematology and Infectious DiseasesBONE MARROW ABONRMALITIES IN HIV INFECTION | Mediterranean Journal of Hematology and Infectious Diseases
ABSTRACT Introduction; Hematological abnormalities are a common complication of HIV infection. Bone marrow abnormalities occur in all stages of HIV infection. Present work was carried out to study the bone marrow abnormalities in patients with HIV/AIDS. Methods: 160 patients of HIV +ve were included in the study. A complete blood count, relevant biochemical investigations, CD4 counts were done, besides a thorough history and clinical examination. HIV positive patients were classified as those having AIDS and those without AIDS according to NACO criteria. Bone marrow examination was performed for indication of anemia, leucopenia, pancytopenia and thrombocytopenia. Results: As per CDC criteria 59.81% patients had AIDS in 107 patients. The most common hematological abnormality was anemia, seen in 93.12% patients. Bone marrow was normocellular in 79.06% of non-AIDS and 79.68% of AIDS, hypocellular in 13.95%.Thrombocytopenia was seen in 4 cases of ART (4.93%) and 3 cases (4.68%) of AIDS group. ...
Bone Marrow Transplant Center (Pediatric & Adult)Bone Marrow Transplant Center (Pediatric & Adult)
Bone Marrow Transplantation. For bone marrow transplantation, not only native stem cells of the patient are used, but also stem cells of another person can be transplanted, if particular criteria are met. Transplantations are categorized according to the source of stem cell.. How bone marrow is obtained for transplantation and how peripheral stem cells are collected for transplantation?. Stem cells to be used in transplantation can be collected from bone marrow, peripheral blood and umbilical cord blood of mothers who deliver recently. Although stem cells collected from peripheral blood are usually primarily preferred, stem cells collected from bone marrow will be preferred in benign diseases, such as aplastic anemia, thalassemia and immune deficiency syndromes.. Peripheral stem cell is harvested with apheresis device after cytokines, which help stem cells in bone marrow migrate to peripheral blood and are referred as granulocyte colony stimulant factor (G-CSF), are used.. For patients in need ...
Bone marrow aspiration: Definition with Bone marrow aspiration Pictures and PhotosBone marrow aspiration: Definition with Bone marrow aspiration Pictures and Photos
Definition of Bone marrow aspiration with photos and pictures, translations, sample usage, and additional links for more information.
Cigarette smoke-induced effects on bone marrow B-cell subsets and CD4 +:CD8+ T-cell ratios are reversed by smoking cessation:...Cigarette smoke-induced effects on bone marrow B-cell subsets and CD4 +:CD8+ T-cell ratios are reversed by smoking cessation:...
TY - JOUR. T1 - Cigarette smoke-induced effects on bone marrow B-cell subsets and CD4 +:CD8+ T-cell ratios are reversed by smoking cessation. T2 - Influence of bone mass on immune cell response to and recovery from smoke exposure. AU - Fusby, Jenny S.. AU - Kassmeier, Michele D.. AU - Palmer, Victoria L.. AU - Perry, Greg A.. AU - Anderson, Dirk K.. AU - Hackfort, Bryan T.. AU - Alvarez, Gwen K.. AU - Cullen, Diane M.. AU - Akhter, Mohammed P.. AU - Swanson, Patrick C.. PY - 2010/8. Y1 - 2010/8. N2 - Cigarette smoking adversely affects the immune system, and is a risk factor for developing osteoporosis. How smoking contributes to osteoporosis is unclear, but since lymphocytes help maintain bone homeostasis and lymphocyte depletion results in bone loss, one potential mechanism for how smoke exposure promotes osteoporosis is by reducing bone marrow lymphocytes. Since the risk for developing osteoporosis is reportedly greater in smokers with polymorphisms in LRP5, a gene involved in canonical Wnt ...
How to prepare for a bone marrow transplant?How to prepare for a bone marrow transplant?
What is bone marrow transplant?. A Bone Marrow Transplant is a medical procedure that is performed for replacing the infected or damaged bone marrow. Bone marrow can be destroyed by complex chemotherapy or infected by a disease. Blood stem cells are transplanted in this process that produces healthy blood cells in the bone marrow and encourage growth in new marrow. Transplants are of two types; autologous transplant (usage of own stem cells) and allogeneic transplant (usage of stem cells from the donor) ...
JC virus in bone marrow of HIV-positive and HIV-negative patients | BMC Proceedings | Full TextJC virus in bone marrow of HIV-positive and HIV-negative patients | BMC Proceedings | Full Text
Of 41 HIV+ patients, 38 were male (93%) and indications for BM biopsies were lymphoma (20), pancytopenia (8), anemia (6), MGUS (2), polycythemia (2), leucopenia (1), splenomegaly (1), and thrombocytopenia (1). Mean age was 47 (range 32-71), mean CD4 count 211 (2-928), 27% had undetectable plasma HIV RNA, and 75% were on HAART. The 47 HIV- controls, matched for indications for BM biopsy, included 32 males (65%), and mean age was 56 (range 27-93). Quantitative PCR detected JCV DNA in BM samples of 19/41 (46%) HIV+ vs 3/47 (6%) of HIV- (p , 0.001). Preliminary immunohistochemistry (IHC) experiments suggest that JCV T antigen is detectable in a fraction of JCV DNA positive bone marrows samples, while JCV VP1 protein was not. Furthermore, JCV was detected by double IHC in some of the plasma cells, myeloid, and lymphoid cells. We then tested fresh BM aspirates, blood and urine samples from 30 HIV- and 6 HIV+ patients. JCV DNA was detectable in 10/36 (28%) fresh BM aspirates, 7/26 (27%) peripheral ...
The human proteome in bone marrow - The Human Protein AtlasThe human proteome in bone marrow - The Human Protein Atlas
Here, the protein-coding genes expressed in the bone marrow are described and characterized, together with examples of immunohistochemically stained tissue sections that visualize protein expression patterns of proteins that correspond to genes with elevated expression in the bone marrow. Transcript profiling and RNA-data analyses based on normal human tissues have been described previously (Fagerberg et al., 2013). Analyses of mRNA expression including over 99% of all human protein-coding genes was performed using deep RNA sequencing of 172 individual samples corresponding to 37 different human normal tissue types. RNA sequencing results of 4 fresh frozen tissues representing normal bone marrow was compared to 168 other tissue samples corresponding to 36 tissue types, in order to determine genes with elevated expression in bone marrow. A tissue-specific score, defined as the ratio between mRNA levels in bone marrow compared to the mRNA levels in all other tissues, was used to divide the genes ...
Bone marrows | definition of bone marrows by Medical dictionaryBone marrows | definition of bone marrows by Medical dictionary
Looking for online definition of bone marrows in the Medical Dictionary? bone marrows explanation free. What is bone marrows? Meaning of bone marrows medical term. What does bone marrows mean?
Roles of bone marrow cells in skeletal metastases: No longer bystanders<...Roles of bone marrow cells in skeletal metastases: No longer bystanders<...
TY - JOUR. T1 - Roles of bone marrow cells in skeletal metastases. T2 - No longer bystanders. AU - Park, Serk In. AU - Soki, Fabiana N.. AU - Mccauley, Laurie K.. PY - 2011/12. Y1 - 2011/12. N2 - Bone serves one of the most congenial metastatic microenvironments for multiple types of solid tumors, but its role in this process remains under-explored. Among many cell populations constituting the bone and bone marrow microenvironment, osteoblasts (originated from mesenchymal stem cells) and osteoclasts (originated from hematopoietic stem cells) have been the main research focus for pro-tumorigenic roles. Recently, increasing evidence further elucidates that hematopoietic lineage cells as well as stromal cells in the bone marrow mediate distinct but critical functions in tumor growth, metastasis, angiogenesis and apoptosis in the bone microenvironment. This review article summarizes the key evidence describing differential roles of bone marrow cells, including hematopoietic stem cells (HSCs), ...
Bone Marrow Aspiration and Biopsy | HealthLink BCBone Marrow Aspiration and Biopsy | HealthLink BC
Blood samples from a vein in your arm may be taken before the bone marrow biopsy. In rare cases, you may be given a blood product (clotting factor or platelets) into a vein (IV) in your arm to prevent bleeding after the biopsy.. Adults usually have a sample of bone marrow fluid taken from the back of the pelvic bone. In rare cases a fluid sample is removed from the breastbone (sternum) or from the front of the pelvic bone. Babies and young children may have the sample taken from the front of the lower leg bone, just below the knee. A bone marrow biopsy is only taken from the pelvic bone.. You may be given a sedative to help you relax. You will lie either on your side or face down on your belly for the biopsy. It is important that you lie still in that position during the biopsy.. The skin over the aspiration site will be cleaned with a special solution and a medicine (local anesthetic) will be used to freeze the area. Then the aspiration needle will be put through your skin and into your bone to ...
Bone Marrow Aspiration and BiopsyBone Marrow Aspiration and Biopsy
Blood samples from a vein in your arm may be taken before the bone marrow biopsy. In rare cases, you may be given a blood product (clotting factor or platelets) into a vein ( IV ) in your arm to prevent bleeding after the biopsy.. Adults usually have a sample of bone marrow fluid taken from the back of the pelvic bone. In rare cases a fluid sample is removed from the breastbone ( sternum ) or from the front of the pelvic bone. Babies and young children may have the sample taken from the front of the lower leg bone, just below the knee. A bone marrow biopsy is only taken from the pelvic bone.. You may be given a sedative to help you relax. You will lie either on your side or facedown on your belly for the biopsy. It is important that you lie still in that position during the biopsy. The skin over the aspiration site will be cleaned with a special solution and a medicine ( local anesthetic ) will be used to numb the area. Then the aspiration needle will be put through your skin and into your bone ...
Bone marrow cells routinely help with wound healingBone marrow cells routinely help with wound healing
Bone marrow has been studied for a number of purposes in recent years because it is rich in stem cells - cells that can go on to become many different kinds of cells. In order to conduct this research, Isik and colleagues obtained a strain of mice whose bodies glow green under fluorescent light. The researchers removed bone marrow from the mice and then performed a stem cell transplant into a genetically identical strain of normal mice, whose cells do not glow green. Afterward, only the bone marrow of the transplanted mice glowed green inside the bodies of the mice, allowing researchers to track the bone marrow cells throughout the body. Researchers found green cells throughout the body, but observed that the highest concentration of bone marrow cells was in normal skin ...
Lack of Development of Thermotolerance in Early Progenitors of Murine Bone Marrow Cells<...Lack of Development of Thermotolerance in Early Progenitors of Murine Bone Marrow Cells<...
TY - JOUR. T1 - Lack of Development of Thermotolerance in Early Progenitors of Murine Bone Marrow Cells. AU - Mivechi, Nahid F.. AU - Li, Gloria C.. N1 - Copyright: Copyright 2016 Elsevier B.V., All rights reserved.. PY - 1986/1/1. Y1 - 1986/1/1. N2 - We have studied the sensitivities of four hematopoietic stem cell types to heat stress as well as their abilities to develop thermotolerance. Granulocyte-macrophage colony forming units were the most heat resistant bone marrow progenitors tested. Of the erythroid progenitors tested, erythrocyte colony forming units were more resistant than the two more primitive erythrocyte burst forming units. To determine their ability to develop thermotolerance, hematopoietic precursors were heated in vivo at 43C for 30 min. At various times thereafter the hematopoietic stem cells were flushed from female C3Hf/Sed mouse preheated tibia. The bone marrow cell suspensions were then heated in vitro and plated for colony formation. The four stem cell precursors ...
National Bone Marrow Transplant Link - NORD (National Organization for Rare Disorders)National Bone Marrow Transplant Link - NORD (National Organization for Rare Disorders)
The National Bone Marrow Transplant Link (nbmtLink) is a non-profit, voluntary organization dedicated to helping patients, as well as their caregivers, families, and the healthcare community, meet the many challenges of bone marrow/stem cell transplants (BMT) by providing vital information and support services. Each year, thousands of patients turn to bone marrow/stem cell transplants to treat cancer and other life-threatening illnesses. While a BMT can be a very effective treatment, it is a long and demanding process for patients and their loved ones. Since its founding in 1992, the National Bone Marrow Transplant Link has helped thousands of individuals worldwide through its comprehensive web site, publications for patients and caregivers, Emmy Award winning video, volunteer peer support programs, resource referrals and educational forums. The National Bone Marrow Transplant Link is funded through private, foundation and corporate donations ...
Depth-dependent concentrations of hematopoietic stem cells in the adult skeleton: Implications for active marrow dosimetry. -...Depth-dependent concentrations of hematopoietic stem cells in the adult skeleton: Implications for active marrow dosimetry. -...
PURPOSE The hematopoietically active (or red) bone marrow is the target tissue assigned in skeletal dosimetry models for assessment of stochastic effects (leukemia induction) as well as tissue reactions (marrow toxicity). Active marrow, however, is in reality a surrogate tissue region for specific cell populations, namely the hematopoietic stem and progenitor cells. Present models of active marrow dosimetry implicitly assume that these cells are uniformly localized throughout the marrow spaces of trabecular spongiosa. Data from Watchman et al. and Bourke et al., however, clearly indicate that there is a substantial spatial concentration gradient of these cells with the highest concentrations localized near the bone trabeculae surfaces. The purpose of the present study was thus to explore the dosimetric implications of these spatial gradients on active marrow dosimetry. METHODS Images of several bone sites from a 45-yr female were retagged to group active marrow voxels into 50 μm increments of marrow
Lymphoproliferations in the bone marrow: identification and evolution, classification and staging. | Journal of Clinical...Lymphoproliferations in the bone marrow: identification and evolution, classification and staging. | Journal of Clinical...
Bone marrow biopsies from 3229 patients with lymphoproliferative disorders and 1156 patients with benign or reactive lymphoproliferations were investigated and criteria for distinguishing between them are given. Bone marrow involvement was found in 89% of multiple myeloma, 64% of non-Hodgkins lymphomas and 8% of Hodgkins disease. According to the predominant proliferative cell type there were five major entities in multiple myeloma and non-Hodgkins lymphomas: (1) plasmacytic; (2) lymphocytic; (3) hairy cell; (4) immunocytic; (5) centrocytic. These were further classified into distinct subtypes each of which had independent prognostic significance. The mode of spread of the lymphoproliferative disorders in the bone marrow showed one of six architectural patterns, which together with the quantity of infiltration in the biopsy (reflecting the tumour cell burden) had significant predictive value. These results demonstrate the value of bone marrow biopsies in the identification, classification and ...
Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation<...Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation<...
TY - JOUR. T1 - Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. AU - Theise, Neil D.. AU - Badve, Sunil. AU - Saxena, Romil. AU - Henegariu, Octavian. AU - Sell, Stewart. AU - Crawford, James M.. AU - Krause, Diane S.. PY - 2000. Y1 - 2000. N2 - Following a report of skeletal muscle regeneration from bone marrow cells, we investigated whether hepatocytes could also derive in vivo from bone marrow cells. A cohort of lethally irradiated B6D2F1 female mice received whole bone marrow transplants from age-matched male donors and were sacrificed at days 1, 3, 5, and 7 and months 2, 4, and 6 posttransplantation (n = 3 for each time point). Additionally, 2 archival female mice of the same strain who had previously been recipients of 200 male fluorescence-activated cell sorter (FACS)-sorted CD34+lin- cells were sacrificed 8 months posttransplantation under the same protocol. Fluorescence in situ hybridization (FISH) for the Y-chromosome was performed on ...
Lasting engraftment of histoincompatible bone marrow cells in dogs (Journal Article) | SciTech ConnectLasting engraftment of histoincompatible bone marrow cells in dogs (Journal Article) | SciTech Connect
Conditioning protocols were tested for their efficacy in increasng the incidence of engraftment of histoincompatible dog bone marrow cells. Cyclophosphamide and total body irradiation (TBI), Corynebacterium parvum and TBI, a 3- or 5-day delayed transfusion of bone marrow cells after TBI, or an increase in the number of donor bone marrow cells or lymphocytes appeared to be ineffective. These protocols were previously reported to promote recovery of splenic hemopoiesis in mice in short-term assays. The noted discrepancy between studies with mice and dogs invalidated allogeneic resistance as measured in the mouse spleen assay as a model for bone marrow allograft rejection. Intravenous treatment with silica particles or L-asparaginase did improve the engraftment rate after 7.5 Gy TBI. Low efficiency and significant extra toxicity restrict the applicability of these procedures. The most promising conditioning schedule found appeared to be two fractions of 6.0 Gy TBI separated by a 72-h interval. ...
Arms / Hands - Whole Arm - Weakness - Bone Marrow Transplant Cancer Treatment | Medical Procedures | MediBidArms / Hands - Whole Arm - Weakness - Bone Marrow Transplant Cancer Treatment | Medical Procedures | MediBid
Bone marrow transplants are used to treat patients with leukemia, multiple myeloma, immune deficiency disorders, aplastic anemia, lymphomas and some cases of breast or ovarian cancer. During a bone marrow transplant the patients existing bone marrow is destroyed and the new healthy bone marrow is infused into the patients blood stream. If the transplant is successful the new bone marrow will begin to produce healthy blood cells ...
Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice - PubMedExercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice - PubMed
The relationship between marrow adipose tissue (MAT) and bone health is poorly understood. We used running exercise to ask whether obesity-associated MAT can be attenuated via exercise and whether this correlates with gains in bone quantity and quality. C57BL/6 mice were divided into diet-induced ob …
Kurre Laboratory | Comprehensive Bone Marrow Failure CenterKurre Laboratory | Comprehensive Bone Marrow Failure Center
With extended training in Pediatric Hematology, Oncology and Stem Cell Transplantation at Fred Hutchinson Cancer Research Center, Dr. Kurres clinical work is now focused on children with bone marrow failure. He strives to provide excellence in care for families and patients across a wide spectrum of inherited and acquired conditions that lead to loss of blood formation. As a Physician Scientist, both clinical and scientific goals of his work are therefore directed at improving understanding and broadening treatment options for patients with bone marrow failure.. Dr. Kurres clinical interests focus on diagnosis and treatment of bone marrow failure and specifically on improving diagnostic and therapeutic capabilities. Advances in genomic technologies provide exciting opportunity to streamline the frequently extended diagnostic work up of children with bone marrow failure. He and colleagues at other institutions are spearheading efforts to leverage molecular technologies toward the development of ...
Marrow Adipose Tissue in Adolescent Girls with Obesity.Marrow Adipose Tissue in Adolescent Girls with Obesity.
Marrow adipose tissue (MAT) is increasingly recognized as an active and dynamic endocrine organ that responds to changes in nutrition and environmental milieu. ...
Regulation of hydrocortisone binding sites by hydrocortisone in human bone marrow fibroblasts - Download PDFRegulation of hydrocortisone binding sites by hydrocortisone in human bone marrow fibroblasts - Download PDF
Minguell, J.J.; Bruzzone, M.S., 1986: Regulation of hydrocortisone binding sites by hydrocortisone in human bone marrow fibroblasts
Bone Marrow AspirationBone Marrow Aspiration
These are photos of me, Jonnie, undergoing a bone marrow aspiration, a diagnostic procedure that leukemia patients like me undergo periodically during treatment. I didnt have much hair then, but it all grew back. The photos were taken at the end of my first year of treatment in May of 2000. My bone marrow was examined for signs of cancer relapse and everything turned out fine. These photos may be difficult for some people to view, but this is the type of painful and frightening procedure kids with leukemia go through before being rewarded with a toy. I hope these photos will help you see for yourself why an incentive like a toy can help a child overcome fear and discomfort and reward them for their bravery or soothe them in their recovery. These photos are in series. They follow the procedure as it happens. Read them from left to right ...
Nanotechnology Now - Press Release: Bone Marrow Gets Targeted Drug DeliveryNanotechnology Now - Press Release: Bone Marrow Gets Targeted Drug Delivery
Germany , Posted on August 19th, 2011. Recently, efforts in development of targeted drug delivery has heavily involved nanotechnology, which uses the strategy of active targeting. Porous silicon is an attractive material because of its biocompatibility and ability to carry various agents, from proteins to drugs and nanoparticles. In a new study featured in Advanced Healthcare Materials, Mauro Ferrari, David Gorenstein and their colleagues developed a system comprising nanoporous silicon particles and a cell adhesion molecule that specifically targets bone marrow and delivers a high amount of nanoparticles containing therapeutic drugs to the bone marrow tissue. The cell adhesion molecule, E-selectin, has recently shown promise as a biological target for the delivery of drug carriers to the bone marrow endothelium. The researchers attached a ligand that has a very high affinity to E-selectin to a porous silicon particle and successfully demonstrated its ability to deliver therapeutic liposomes ...
Serum Lactate Dehydrogenase 2 Isoenzyme as Marker of Bone Marrow Infiltration in Non Hodgkin Lymphoma | International Journal...Serum Lactate Dehydrogenase 2 Isoenzyme as Marker of Bone Marrow Infiltration in Non Hodgkin Lymphoma | International Journal...
Aims and Objectives: Patients were divided into two groups, 30 patients with bone marrow infiltration (group B) and remaining without infiltration (group C). The values were compared with 20 healthy age and sex matched contrtols (groupA). The estimations were made prior to the institution of chemotherapy ...
Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and...Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and...
TY - JOUR. T1 - Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. AU - Nguyen, Aaron N.. AU - Stebbins, Elizabeth G.. AU - Henson, Margaret. AU - OYoung, Gilbert. AU - Choi, Sun J.. AU - Quon, Diana. AU - Damm, Debby. AU - Reddy, Mamatha. AU - Ma, Jing Y.. AU - Haghnazari, Edwin. AU - Kapoun, Ann M.. AU - Medicherla, Satyanarayana. AU - Protter, Andy. AU - Schreiner, George F.. AU - Kurihara, Noriyoshi. AU - Anderson, Judy. AU - Roodman, G. David. AU - Navas, Tony A.. AU - Higgins, Linda S.. PY - 2006/6/10. Y1 - 2006/6/10. N2 - The multiple myeloma (MM) bone marrow (BM) microenvironment plays a critical role in supporting tumor growth and survival as well as in promoting formation of osteolytic lesions. Recent results suggest that the p38 mitogen-activated protein kinase (MAPK) is an important factor in maintaining this activated environment. In this report, we demonstrate that the p38α ...
Stomach Cancer May Start in Bone Marrow - RedorbitStomach Cancer May Start in Bone Marrow - Redorbit
HealthDayNews -- Stomach cancer may originate from bone marrow cells rather than stomach cells, as was previously believed. A new study in mice found that stomach cancer cells began as bone marrow cells that had migrated to the stomach. The bone marrow cells traveled to the stomach in response to inflammation caused by an infection with the bacterium that causes ulcers, Helicobacter pylori. These findings, published in the Nov. 26 issue of Science, are in stark contrast to the commonly held belief that cancers originate from the tissue in the surrounding area, meaning that it was believed that stomach cancer begins from stomach stem cells. "In the last five years or so, weve learned that bone marrow-derived stem cells can go to sites of injury and mimic epithelial cells [from that region], which raised the possibility that bone marrow cells could play a role in the development of cancer in that area," said one of the studys authors, Dr. Timothy Wang, chief of the division of digestive and ...
BONE MARROW ORIGIN OF IMMUNOLOGICALLY COMPETENT LYMPHOCYTES IN THE RAT | JEMBONE MARROW ORIGIN OF IMMUNOLOGICALLY COMPETENT LYMPHOCYTES IN THE RAT | JEM
Rat bone marrow is deficient in immunologically competent cells when compared with the peripheral pool of circulating small lymphocytes. However, circulating lymphocytes capable of initiating a lethal graft vs. host reaction can develop from myeloid precursors. In adult rats inoculated at birth with parental strain bone marrow cells, the thoracic duct lymph contains cells having the immunological capability of the marrow donor. The evidence suggests that immunologically competent lymphocytes derive from cells normally resident in bone marrow and probably not from precursors in the peripheral lymphocyte pool.. ...
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Bone marrow - definition of bone marrow by The Free DictionaryBone marrow - definition of bone marrow by The Free Dictionary
Daniel Kraft: A better way to harvest bone marrow | TED TalkDaniel Kraft: A better way to harvest bone marrow | TED Talk
Does having a bone marrow biopsy hurt? | Reference.comDoes having a bone marrow biopsy hurt? | Reference.com
Low bone marrow volume -Doctors Lounge(TM)Low bone marrow volume -Doctors Lounge(TM)
Pflugerville officer seeks bone marrow donor for ill daughter - News - Austin American-Statesman - Austin, TXPflugerville officer seeks bone marrow donor for ill daughter - News - Austin American-Statesman - Austin, TX
bone marrow biopsy | Cancer Survivors Networkbone marrow biopsy | Cancer Survivors Network
Bone marrow | anatomy | Britannica.comBone marrow | anatomy | Britannica.com
Bone marrow examination - WikipediaBone marrow examination - Wikipedia
Figure 1 | Bone Marrow TransplantationFigure 1 | Bone Marrow Transplantation
Bone MarrowBone Marrow
Bone Marrow Transplantation - Table of ContentsBone Marrow Transplantation - Table of Contents
Bone Marrow Transplant: What HappensBone Marrow Transplant: What Happens
Bone-marrow Grafts | The BMJBone-marrow Grafts | The BMJ
Bone marrow adipocytes. - PubMed - NCBIBone marrow adipocytes. - PubMed - NCBI
Bone Marrow | SpringerLinkBone Marrow | SpringerLink
Bone Marrow TransplantBone Marrow Transplant
Bone Marrow DiseasesBone Marrow Diseases
Bone Marrow Diseases - Multiple Languages: MedlinePlusBone Marrow Diseases - Multiple Languages: MedlinePlus
Bone marrow transplant: MedlinePlus Medical EncyclopediaBone marrow transplant: MedlinePlus Medical Encyclopedia
Causes of subchondral bone marrow edemaCauses of subchondral bone marrow edema
Bone marrow transplant | medicine | Britannica.comBone marrow transplant | medicine | Britannica.com
Bone marrow and mental illness - NHSBone marrow and mental illness - NHS
Bone Marrow Awareness WeekBone Marrow Awareness Week
Bone marrow - Mayo ClinicBone marrow - Mayo Clinic
Saving Lives By Creating A Bone Marrow RegistrySaving Lives By Creating A Bone Marrow Registry
Bone marrow transplantation. (eJournal / eMagazine) [WorldCat.org]Bone marrow transplantation. (eJournal / eMagazine) [WorldCat.org]
Bone marrow cancer: Symptoms, treatment, and outlookBone marrow cancer: Symptoms, treatment, and outlook
Bone Marrow Aspirate and BiopsyBone Marrow Aspirate and Biopsy
Bone marrow transplant - Mayo ClinicBone marrow transplant - Mayo Clinic
Bone Marrow Aspiration and BiopsyBone Marrow Aspiration and Biopsy
Scientists grow sperm from bone marrow | Daily Mail OnlineScientists grow sperm from bone marrow | Daily Mail Online
Toddler Meets Life-Saving Bone Marrow Donor - ABC NewsToddler Meets Life-Saving Bone Marrow Donor - ABC News
bone marrow aspirationbone marrow aspiration
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Young Actress Waiting for Bone Marrow Donor - RedorbitYoung Actress Waiting for Bone Marrow Donor - Redorbit
AnatomyDiseasesAnalytical, Diagnostic and Therapeutic Techniques and EquipmentAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation Science
Bone Marrow ExaminationBone MarrowPancytopeniaBone Marrow CellsLymphohistiocytosis, HemophagocyticRed-Cell Aplasia, PureBone Marrow TransplantationTransplantation, HomologousHematopoietic Stem Cell TransplantationGraft vs Host DiseaseTransplantation ConditioningElectronic MailFood Dispensers, AutomaticEditorial PoliciesAuthorshipPeriodicals as TopicPostal ServiceInternetHematologic NeoplasmsBone and BonesLeukemiaMyelodysplastic-Myeloproliferative DiseasesBiopsy, NeedleHistiocytosis, Non-Langerhans-CellBone Marrow NeoplasmsBiopsy
TransplantationProcedureTissueBonesHuman bone-marrowNeedleCancersAspiration and BiopsyCells in the bone maDonorsPlateletsTransplantsInternational Journal of Bone Marrow ResearchPAXgene Bone Marrow RNA SystemHaving a bone marrowTypes of bone marrow containGetting a sample of bone marrowYellow marrow back to red marrowBiopsiesStem Cells from Bone MarrowCancerMiceAplastic anemiaPeripheralTrephineBiopsy and aspirationAdultProducesTypically
Transplantation1
Procedure16
Tissue16
Bones11
Human bone-marrow1
  • It is intended for the collection, storage, and transport of human bone marrow and stabilization of intracellular RNA in a closed tube and subsequent isolation and purification of total RNA. (preanalytix.com)
Needle16
Cancers3
Aspiration and Biopsy1
Cells in the bone ma1
Donors1
Platelets6
Transplants1
  • International Journal of Bone Marrow Research seeks to publish manuscripts focusing on the researches how the doctors would need less stem cells and increase the scale of doing more transplants. (heighpubs.org)
International Journal of Bone Marrow Research4
  • International Journal of Bone Marrow Research publishes rigorously peer-reviewed manuscripts focusing on latest advancements related to all aspects of bone marrow. (heighpubs.org)
  • International Journal of Bone Marrow Research aims to publish valuable researches encompassing all aspects of bone marrow research that can assist in making bone marrow, stem cell or cord blood transplant an overwhelming experience for the patients and the doctors. (heighpubs.org)
  • The manuscripts published in International Journal of Bone Marrow Research also seek to focus on the vital role of bone marrow in understanding blood and autoimmune diseases and in evaluating treatment options for patients. (heighpubs.org)
  • The scope of International Journal of Bone Marrow Research reclines in uncovering new pathways and molecular mechanisms that contribute and highlight new avenues in bone marrow research. (heighpubs.org)
PAXgene Bone Marrow RNA System1
  • The PAXgene Bone Marrow RNA System consists of a bone marrow collection tube ( PAXgene Bone Marrow RNA Tube ) and nucleic acid preparation kit (PAXgene Bone Marrow RNA Kit). (preanalytix.com)
Having a bone marrow1
Types of bone marrow contain1
Getting a sample of bone marrow1
Yellow marrow back to red marrow2
Biopsies2
Stem Cells from Bone Marrow1
  • A team of scientists and engineers at the Singapore-MIT Alliance for Research and Technology (SMART) [新加坡-麻省理工学院科研中心] have invented a new technique to identify populations of rare stem cells from bone marrow based on their different combinations of biophysical characteristics such as cell size, cell stiffness and nucleus deformation. (mit.edu)
Cancer1
  • The reason for taking this sample is that as my form of cancer is related to white blood cells, there is a chance that the bone marrow has been infected. (robinbtaylor.com)
Mice2
  • Anti-human CD117 antibody-mediated bone marrow niche clearance in nonhuman primates and humanized NSG mice. (ca.gov)
  • Fish oil and borage oil (rich in ω3 fatty acids) can partially prevent aged-related bone loss in SAMP8 mice. (aging-us.com)
Aplastic anemia1
  • For patients who have certain malignancies of the blood and bone marrow (such as leukemias and lymphomas), or autoimmune diseases (such as systemic lupus erythematosus), or other blood-related disorders (like aplastic anemia and thalassemia major), HSCT has been part of the standard treatment regimen, backed by large and long-term studies on efficacy. (negosentro.com)
Peripheral1
Trephine1
Biopsy and aspiration1
Adult3
Produces2
Typically1
What is Bone Marrow?
What is Bone Marrow? (news-medical.net)
Bone-marrow donor and recipient meet for first time
Bone-marrow donor and recipient meet for first time (azcentral.com)
NCSU students promote bone marrow registry | Raleigh News & Observer
NCSU students promote bone marrow registry | Raleigh News & Observer (newsobserver.com)
9-Year-Old Twin Sisters Dance With Bone Marrow Donor Who Saved Them
9-Year-Old Twin Sisters Dance With Bone Marrow Donor Who Saved Them (yahoo.com)
49er Helping Family Look for Bone Marrow Match - NBC Bay Area
49er Helping Family Look for Bone Marrow Match - NBC Bay Area (nbcbayarea.com)
Football star's final play: Donating bone marrow to mom with leukemia
Football star's final play: Donating bone marrow to mom with leukemia (app.com)
Bone + Marrow Market | Enneagram Gifts + Experiences (boneandmarrowmarket) - Profile | Pinterest
Bone + Marrow Market | Enneagram Gifts + Experiences (boneandmarrowmarket) - Profile | Pinterest (pinterest.com)
MSC Therapy Attenuates Obliterative Bronchiolitis after Murine Bone Marrow Transplant
MSC Therapy Attenuates Obliterative Bronchiolitis after Murine Bone Marrow Transplant (journals.plos.org)
First aid course calgary, eat to live food list, what is reactive bone marrow edema
First aid course calgary, eat to live food list, what is reactive bone marrow edema (s3.amazonaws.com)
PatEdu.com : Bone Marrow Diseases
PatEdu.com : Bone Marrow Diseases (patient-education.com)
CiteSeerX - Search Results - An automatic 3D CT/PET segmentation framework for bone marrow proliferation assessment
CiteSeerX - Search Results - An automatic 3D CT/PET segmentation framework for bone marrow proliferation assessment (citeseerx.ist.psu.edu)
Bone Marrow-Infiltrating Human Neuroblastoma Cells Express High Levels of Calprotectin and HLA-G Proteins
Bone Marrow-Infiltrating Human Neuroblastoma Cells Express High Levels of Calprotectin and HLA-G Proteins (journals.plos.org)
'Bubble baby' with Cambria ties recovers after bone-marrow transplant | San Luis Obispo...
'Bubble baby' with Cambria ties recovers after bone-marrow transplant | San Luis Obispo... (sanluisobispo.com)
Expansion of Human Mesenchymal Stromal Cells from Fresh Bone Marrow in a 3D Scaffold-Based System under Direct Perfusion
Expansion of Human Mesenchymal Stromal Cells from Fresh Bone Marrow in a 3D Scaffold-Based System under Direct Perfusion (journals.plos.org)
Bison Bone Marrow | Subscription - Northstar Bison
Bison Bone Marrow | Subscription - Northstar Bison (northstarbison.com)
Enrichment and Molecular Analysis of Breast Cancer Disseminated Tumor Cells from Bone Marrow Using Microfiltration
Enrichment and Molecular Analysis of Breast Cancer Disseminated Tumor Cells from Bone Marrow Using Microfiltration (journals.plos.org)
Toll-Like Receptor 3 and Suppressor of Cytokine Signaling Proteins Regulate CXCR4 and CXCR7 Expression in Bone Marrow-Derived...
Toll-Like Receptor 3 and Suppressor of Cytokine Signaling Proteins Regulate CXCR4 and CXCR7 Expression in Bone Marrow-Derived... (journals.plos.org)
Vote for Help Cancer Patients Find Bone Marrow Donors! - GlobalGiving 2014 Photo Contest - GlobalGiving
Vote for Help Cancer Patients Find Bone Marrow Donors! - GlobalGiving 2014 Photo Contest - GlobalGiving (globalgiving.org)
रक्ताचा कर्करोग झालेल्या रूग्णावर असे झाले यशस्वी उपचार | Successful treatment of bone marrow transplant in a patient with...
रक्ताचा कर्करोग झालेल्या रूग्णावर असे झाले यशस्वी उपचार | Successful treatment of bone marrow transplant in a patient with... (zeenews.india.com)
Bone Marrow Stromal Cells Derived MCP-1 Reverses the Inhibitory Effects of Multiple Myeloma Cells on Osteoclastogenesis by...
Bone Marrow Stromal Cells Derived MCP-1 Reverses the Inhibitory Effects of Multiple Myeloma Cells on Osteoclastogenesis by... (journals.plos.org)
Histology of bone marrow granuloma, H& E, low power | British Society for Haematology
Histology of bone marrow granuloma, H& E, low power | British Society for Haematology (b-s-h.org.uk)
Stem Cell Therapies Offer Hope in Mexico | Adult Stem Cell Therapy | Bone Marrow Stem Cell Therapy | Cardiac Stem Cell Therapy ...
Stem Cell Therapies Offer Hope in Mexico | Adult Stem Cell Therapy | Bone Marrow Stem Cell Therapy | Cardiac Stem Cell Therapy ... (placidway.com)
JCDR - Cervical cancer, Haematological toxicity, Pelvic bone marrow, Volumetric modulated arc radiotherapy
JCDR - Cervical cancer, Haematological toxicity, Pelvic bone marrow, Volumetric modulated arc radiotherapy (jcdr.net)
Bone Marrow Deep Penetrating Conditioner 16 fl. oz : Professional Beauty Supply & Salon Equipment Store - Beauty Supplies &...
Bone Marrow Deep Penetrating Conditioner 16 fl. oz : Professional Beauty Supply & Salon Equipment Store - Beauty Supplies &... (probeauty-supply.com)
Culture of bone marrow stromal cells and mesenchymal stem cells
Culture of bone marrow stromal cells and mesenchymal stem cells (protocols.io)
Hematopoietic stem cell transplantation - Wikipedia
Hematopoietic stem cell transplantation - Wikipedia (en.wikipedia.org)
Marrow Bone Spring
Marrow Bone Spring (theclio.com)
Bone Marrow Transplant
Bone Marrow Transplant (danthospital.com)
Donor and recipient plasma follistatin levels are associated with acute GvHD in Blood and Marrow Transplant Clinical Trials...
Donor and recipient plasma follistatin levels are associated with acute GvHD in Blood and Marrow Transplant Clinical Trials... (nature.com)
Impact of pretransplant donor-specific anti-HLA antibodies on cord blood transplantation on behalf of the Transplant...
Impact of pretransplant donor-specific anti-HLA antibodies on cord blood transplantation on behalf of the Transplant... (nature.com)
High prevalence of CD3, NK, and NKT cells in the graft predicts adverse outcome after matched-related and unrelated...
High prevalence of CD3, NK, and NKT cells in the graft predicts adverse outcome after matched-related and unrelated... (nature.com)
Bone marrow | anatomy | Britannica.com
Bone marrow | anatomy | Britannica.com (britannica.com)
Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer | Nature...
Radionuclides transform chemotherapeutics into phototherapeutics for precise treatment of disseminated cancer | Nature... (nature.com)
Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis | Nature Communications
Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis | Nature Communications (nature.com)