Diseases of BONES.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Bone loss due to osteoclastic activity.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.
Tumors or cancer located in bone tissue or specific BONES.
Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Dissolution of bone that particularly involves the removal or loss of calcium.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
Breaks in bones.
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.
Syndromes of bone destruction where the cause is not obvious such as neoplasia, infection, or trauma. The destruction follows various patterns: massive (Gorham disease), multicentric (HAJDU-CHENEY SYNDROME), or carpal/tarsal.
The process of bone formation. Histogenesis of bone including ossification.
A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.
Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
The largest of three bones that make up each half of the pelvic girdle.
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.
A VITAMIN D that can be regarded as a reduction product of vitamin D2.
Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)
The grafting of bone from a donor site to a recipient site.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.
Diseases of the bones related to hyperfunction or hypofunction of the endocrine glands.
A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Abnormally high level of calcium in the blood.
Stable strontium atoms that have the same atomic number as the element strontium, but differ in the atomic weight. Sr-84, 86, 87, and 88 are the stable strontium isotopes.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
Death of a bone or part of a bone, either atraumatic or posttraumatic.
A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.
A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.
A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).
Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.
A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.
A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher.
An abnormal hardening or increased density of bone tissue.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.
Bone diseases caused by pathogenic microorganisms.
COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.
Inorganic compounds that contain TECHNETIUM as an integral part of the molecule. Technetium 99m (m=metastable) is an isotope of technetium that has a half-life of about 6 hours. Technetium 99, which has a half-life of 210,000 years, is a decay product of technetium 99m.
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.
Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
A coronary vasodilator agent.
A circular structural unit of bone tissue. It consists of a central hole, the Haversian canal through which blood vessels run, surrounded by concentric rings, called lamellae.
Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.
A condition of an abnormally low level of PHOSPHATES in the blood.
Inorganic salts of phosphoric acid.
Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
AMINO ACIDS composed of GLYCINE substituted at the nitrogen rather than the usual carbon position, resulting in the loss of HYDROGEN BONDING donors. Polymers of these compounds are called PEPTOIDS.
A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.
Formation of stones in the KIDNEY.
Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia.
The spinal or vertebral column.
Excision of one or more of the parathyroid glands.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The bone that forms the frontal aspect of the skull. Its flat part forms the forehead, articulating inferiorly with the NASAL BONE and the CHEEK BONE on each side of the face.
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.
A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.
Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.
Elements of limited time intervals, contributing to particular results or situations.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.
Local surroundings with which cells interact by processing various chemical and physical signals, and by contributing their own effects to this environment.
A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.
Pathologic deposition of calcium salts in tissues.
Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.
A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.
A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.
The bones of the free part of the lower extremity in humans and of any of the four extremities in animals. It includes the FEMUR; PATELLA; TIBIA; and FIBULA.
A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
Removal of bone marrow and evaluation of its histologic picture.
Fractures of the femur.
The five cylindrical bones of the METACARPUS, articulating with the CARPAL BONES proximally and the PHALANGES OF FINGERS distally.
Inorganic or organic compounds that contain the basic structure RB(OH)2.
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.
Tumors or cancer of the human BREAST.
The five long bones of the METATARSUS, articulating with the TARSAL BONES proximally and the PHALANGES OF TOES distally.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
The seven bones which form the tarsus - namely, CALCANEUS; TALUS; cuboid, navicular, and the internal, middle, and external cuneiforms.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
CCR receptors with specificity for a broad variety of CC CHEMOKINES. They are expressed at high levels in MONOCYTES; tissue MACROPHAGES; NEUTROPHILS; and EOSINOPHILS.
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.
Cholecalciferols substituted with two hydroxy groups in any position.
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.
The TARSAL BONES; METATARSAL BONES; and PHALANGES OF TOES. The tarsal bones consists of seven bones: CALCANEUS; TALUS; cuboid; navicular; internal; middle; and external cuneiform bones. The five metatarsal bones are numbered one through five, running medial to lateral. There are 14 phalanges in each foot, the great toe has two while the other toes have three each.
Tumors or cancer of the PROSTATE.
LDL-receptor related protein that combines with FRIZZLED RECEPTORS at the cell surface to form receptors that bind WNT PROTEINS. The protein plays an important role in the WNT SIGNALING PATHWAY in OSTEOBLASTS and during EMBRYONIC DEVELOPMENT.
An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
The outer shorter of the two bones of the FOREARM, lying parallel to the ULNA and partially revolving around it.
A surgical specialty which utilizes medical, surgical, and physical methods to treat and correct deformities, diseases, and injuries to the skeletal system, its articulations, and associated structures.
A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.
Fibrous blood-filled cyst in the bone. Although benign it can be destructive causing deformity and fractures.
Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
The giving of drugs, chemicals, or other substances by mouth.
The surgical removal of one or both ovaries.
A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
A bone morphogenetic protein that is a potent inducer of BONE formation. It plays additional roles in regulating CELL DIFFERENTIATION of non-osteoblastic cell types and epithelial-mesenchymal interactions.
The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
Progenitor cells from which all blood cells derive.
Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Implantable fracture fixation devices attached to bone fragments with screws to bridge the fracture gap and shield the fracture site from stress as bone heals. (UMDNS, 1999)
The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).
Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.
A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).

22-oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure. (1/779)

BACKGROUND: Calcitriol therapy suppresses serum levels of parathyroid hormone (PTH) in patients with renal failure but has several drawbacks, including hypercalcemia and/or marked suppression of bone turnover, which may lead to adynamic bone disease. A new vitamin D analogue, 22-oxacalcitriol (OCT), has been shown to have promising characteristics. This study was undertaken to determine the effects of OCT on serum PTH levels and bone turnover in states of normal or impaired renal function. METHODS: Sixty dogs were either nephrectomized (Nx, N = 38) or sham-operated (Sham, N = 22). The animals received supplemental phosphate to enhance PTH secretion. Fourteen weeks after the start of phosphate supplementation, half of the Nx and Sham dogs received doses of OCT (three times per week); the other half were given vehicle for 60 weeks. Thereafter, the treatment modalities for a subset of animals were crossed over for an additional eight months. Biochemical and hormonal indices of calcium and bone metabolism were measured throughout the study, and bone biopsies were done at baseline, 60 weeks after OCT or vehicle treatment, and at the end of the crossover period. RESULTS: In Nx dogs, OCT significantly decreased serum PTH levels soon after the induction of renal insufficiency. In long-standing secondary hyperparathyroidism, OCT (0.03 microg/kg) stabilized serum PTH levels during the first months. Serum PTH levels rose thereafter, but the rise was less pronounced compared with baseline than the rise seen in Nx control. These effects were accompanied by episodes of hypercalcemia and hyperphosphatemia. In animals with normal renal function, OCT induced a transient decrease in serum PTH levels at a dose of 0.1 microg/kg, which was not sustained with lowering of the doses. In Nx dogs, OCT reversed abnormal bone formation, such as woven osteoid and fibrosis, but did not significantly alter the level of bone turnover. In addition, OCT improved mineralization lag time, (that is, the rate at which osteoid mineralizes) in both Nx and Sham dogs. CONCLUSIONS: These results indicate that even though OCT does not completely prevent the occurrence of hypercalcemia in experimental dogs with renal insufficiency, it may be of use in the management of secondary hyperparathyroidism because it does not induce low bone turnover and, therefore, does not increase the risk of adynamic bone disease.  (+info)

Osteopenia in the patient with cancer. (2/779)

Osteopenia is defined as a reduction in bone mass. It is commonly known to occur in elderly people or women who are postmenopausal due to hormonal imbalances. This condition, however, can result because of many other factors, such as poor nutrition, prolonged pharmacological intervention, disease, and decreased mobility. Because patients with cancer experience many of these factors, they are often predisposed to osteopenia. Currently, patients with cancer are living longer and leading more fulfilling lives after treatment. Therefore, it is imperative that therapists who are responsible for these patients understand the risk factors for osteopenia and their relevance to a patient with cancer.  (+info)

A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. (3/779)

The molecular mechanisms controlling bone extracellular matrix (ECM) deposition by differentiated osteoblasts in postnatal life, called hereafter bone formation, are unknown. This contrasts with the growing knowledge about the genetic control of osteoblast differentiation during embryonic development. Cbfa1, a transcriptional activator of osteoblast differentiation during embryonic development, is also expressed in differentiated osteoblasts postnatally. The perinatal lethality occurring in Cbfa1-deficient mice has prevented so far the study of its function after birth. To determine if Cbfa1 plays a role during bone formation we generated transgenic mice overexpressing Cbfa1 DNA-binding domain (DeltaCbfa1) in differentiated osteoblasts only postnatally. DeltaCbfa1 has a higher affinity for DNA than Cbfa1 itself, has no transcriptional activity on its own, and can act in a dominant-negative manner in DNA cotransfection assays. DeltaCbfa1-expressing mice have a normal skeleton at birth but develop an osteopenic phenotype thereafter. Dynamic histomorphometric studies show that this phenotype is caused by a major decrease in the bone formation rate in the face of a normal number of osteoblasts thus indicating that once osteoblasts are differentiated Cbfa1 regulates their function. Molecular analyses reveal that the expression of the genes expressed in osteoblasts and encoding bone ECM proteins is nearly abolished in transgenic mice, and ex vivo assays demonstrated that DeltaCbfa1-expressing osteoblasts were less active than wild-type osteoblasts. We also show that Cbfa1 regulates positively the activity of its own promoter, which has the highest affinity Cbfa1-binding sites characterized. This study demonstrates that beyond its differentiation function Cbfa1 is the first transcriptional activator of bone formation identified to date and illustrates that developmentally important genes control physiological processes postnatally.  (+info)

Glucocorticoid-induced secondary osteopenia in female rats: a time course study as compared with ovariectomy-induced osteopenia and response to salmon calcitonin. (4/779)

Previously we reported that 8-week treatment with methylprednisolone acetate (MPA: 0.1 mg/kg, s.c., 3 days a week) of male rats caused a novel type of osteopenia whose development was prevented by salmon calcitonin (SCT) in a dose-dependent manner. In this study, to compare the MPA-inducible osteopenia with the ovariectomy (OVX)-inducible one, female rats were used instead of male rats and a time-course study of development was made. MPA treatments for 1, 2, 4 and 8 weeks histologically induced characteristic osteopenic changes in a time-dependent manner that were histomorphometrically detectable in tibiae within 4 weeks as reduced bone mass, accelerated bone resorption, and suppressed bone formation and mineralization. Node-strut analysis revealed that the connectivity of the trabecular structure remained unaffected. Such MPA-induced changes in the trabecular structure, to be defined as thinned-but-uncut, is in a good contrast with OVX-induced unthinned-but-cut structure, although the latter osteopenic changes became detectable 2 weeks earlier. Another previous finding confirmed herein was that MPA-induced osteopenia in female rats was also completely masked by SCT (10 U/kg, s.c., 5 days a week). The results indicate that the MPA-inducible secondary osteopenic model in either sex of rats would be usable for testing anti-osteopenic drugs.  (+info)

Bone loss in long-term renal transplantation: histopathology and densitometry analysis. (5/779)

BACKGROUND: There is little information of the spectrum and factors implicated in the bone loss in long-term renal transplantation, and virtually no data using both histomorphometric and densitometric analysis. METHODS: Twenty-three males and 22 females (13 postmenopausal) were studied with a bone biopsy and densitometry. Sixteen patients were on cyclosporine A monotherapy, 20 on azathioprine + prednisolone, and 9 on cyclosporine A + prednisolone or triple therapy. The mean time after transplantation was 127 +/- 70 months. RESULTS: No group had a significant decrease in bone mineral density (BMD) of the axial skeleton compared with an age- and sex-matched normal population. Compared with sex-matched young controls, osteopenia was observed in all groups at the femoral neck (except premenopausal women and triple therapy) and in the triple-therapy group at the L1-L4 spine region. At the distal radius, osteopenia was found in all the groups. Histopathological diagnosis was mixed uremic osteodystrophy in 46.5%, adynamic bone in 23.2%, hyperparathyroid disease in 13.9%, and normal bone in 16.3%. The diagnosis was not different according to immunosuppressive therapy, but men tended to show more mixed uremic bone disease. There was no significant difference in BMD between histopathological subtypes. In general, patients showed slight osteoclast function increase, osteoblast function decrease, and marked retardation of dynamic parameters. The cyclosporine A monotherapy group had a significantly lower appositional rate than azathioprine + prednisolone. Men had a significantly lower bone volume than women, and premenopausal women had a significantly lower mineralizing surface than postmenopausal women and men. In the multivariate analysis, male gender, time after transplantation, old age, and time on dialysis prior to transplantation were significant predictive factors for a negative effect on bone mass. CONCLUSIONS: Long-term renal transplant-patients showed reduced BMD in both trabecular and cortical bone. This reduction in BMD was not as severe as in short-term reports and was associated with osteoclast stimulation, osteoblast suppression, and retardation of mineral apposition and bone formation rates. Bone mass loss was not different between the immunosuppression therapy groups. Male gender and age were the strongest predictive factors for low bone mass.  (+info)

Reduced bone density at completion of chemotherapy for a malignancy. (6/779)

OBJECTIVES: Osteoporosis and pathological fractures occur occasionally in children with malignancies. This study was performed to determine the degree of osteopenia in children with a malignancy at completion of chemotherapy. METHODS: Lumbar spine (L2-L4) bone mineral density (BMD; g/cm2) and femoral neck BMD were measured by dual energy x ray absorptiometry in 22 children with acute lymphoblastic leukaemia (ALL), and in 26 children with other malignancies. Apparent volumetric density was calculated to minimise the effect of bone size on BMD. Results were compared with those of 113 healthy controls and expressed as age and sex standardised mean Z scores. RESULTS: Patients with ALL had significantly reduced lumbar volumetric (-0.77) and femoral areal and volumetric BMDs (-1.02 and -0.98, respectively). In patients with other malignancies, femoral areal and apparent volumetric BMDs were significantly decreased (-0.70 and -0.78, respectively). CONCLUSIONS: The results demonstrate that children with a malignancy are at risk of developing osteopenia. A follow up of BMD after the completion of chemotherapy should facilitate the identification of patients who might be left with impaired development of peak bone mass, and who require specific interventions to prevent any further decrease in their skeletal mass and to preserve their BMD.  (+info)

Is low plasma 25-(OH)vitamin D a major risk factor for hyperparathyroidism and Looser's zones independent of calcitriol? (7/779)

BACKGROUND: Recent reports suggest that calcitriol might not be the sole active metabolite of vitamin D and that plasma concentrations of 25-(OH)vitamin D (25OHD) are often abnormally low in hemodialysis patients. We have therefore evaluated plasma 25OHD as a risk factor for parathyroid hormone (PTH) hypersecretion and radiological bone disease. We carried out a cross-sectional study during the month of September in an Algerian dialysis center of 113 patients who were not taking supplements of alphacalcidol or calcitriol. METHODS: Plasma 25OHD, calcitriol, PTH, calcium, phosphate, bicarbonate, and aluminum were measured, and x-rays of the hands and pelvis were obtained for evaluation of subperiosteal resorption and Looser's zones. RESULTS: The median plasma 25OHD was 47.5 nmol/liter (range 2.5 to 170.0). Univariate analysis showed that plasma PTH was correlated positively with months on maintenance dialysis and negatively with plasma 25OHD, calcitriol, calcium, bicarbonate and aluminum, but not with that of phosphate. plasma 25OHD was positively correlated with calcium and calcitriol. Using multiple regression analysis, only plasma 25OHD (negative) and the duration on maintenance dialysis (positive) were independently linked to plasma PTH. The prevalence of isolated subperiosteal resorption (ISR) was 34%, and that of the combination of resorption with Looser's zones (CRLZ) was 9%; thus, only 57% of the patients had a normal x-ray appearance. These groups were comparable with regards to age, gender, and duration on dialysis. When the biochemical measurements of the patients with CRLZ were compared with those from patients without radiological lesions, plasma 25OHD was the only parameter to show a statistically significant difference, being significantly lower in the CRLZ group (26 +/- 18 vs. 57 nmol/liter, ANOVA, P < 0.004). Plasma 25OHD was also significantly lower in the ISR group (44, P < 0.05) than in the normal x-ray group, and plasma Ca (P < 0.003) and bicarbonate (P < 0.02) were lower. Logistical analysis showed that the presence of resorption was independently linked only with plasma PTH. Looser's zones and subperiosteal resorption were not seen in patients with plasma 25OHD of more than 40 (Looser's zones) and more than 100 nmol/liter (subperiosteal resorption). The optimal range for intact PTH in hemodialysis patients with mild aluminum overload is 10 to 25 pmol/liter. We found that plasma PTH was inappropriately high only when plasma 25OHD was less than 100 nmol/liter. With a plasma 25OHD of between 100 and 170 nmol/liter, hypercalcemia was present with a plasma PTH of less than 10 pmol/liter in only one case. CONCLUSIONS: This cross sectional study shows that low plasma 25OHD is a major risk factor for hyperparathyroidism and Looser's zones. In dialysis patients, we suggest that the plasma levels of 25OHD are maintained around the upper limit of the reference range of sunny countries.  (+info)

Effects of XT-44, a phosphodiesterase 4 inhibitor, in osteoblastgenesis and osteoclastgenesis in culture and its therapeutic effects in rat osteopenia models. (8/779)

We have reported that denbufylline, a phosphodiesterase 4 (PDE4) inhibitor, inhibits bone loss in Walker256/S tumor-bearing rats, suggesting therapeutic potentiality of a PDE4 inhibitor in osteopenia. In the present study, effects of a new PDE4 inhibitor, 1-n-butyl-3-n-propylxanthine (XT-44), in bone were evaluated in cell cultures and animal experiments. In rat bone marrow culture, XT-44 stimulated mineralized-nodule formation, whereas it inhibited osteoclast-like cell formation in mouse bone marrow culture. In Walker256/S-bearing rats (6-week-old female Wistar Imamichi rats), rapid decrease in bone mineral density (BMD) was prominent, and oral administration of XT-44 (0.3 mg/kg, every 2 days) inhibited the decrease in BMD. In the second animal experiment, female Wistar rats (6-week-old) were sciatic neurectomized, and XT-44 was orally administered to these rats every 2 days for 4 weeks. XT-44 administration (0.3 mg/kg) recovered BMD in these neurectomized animals. Furthermore, 19-week-old, female Wistar rats were ovariectomized (OVX), and 15 weeks after surgery, these rats were orally administered XT-44 every 2 days for 8 weeks. XT-44 treatment (1 mg/kg) increased the BMD of OVX rats. These results indicate that XT-44 could be a candidate as a therapeutic drug for treating osteopenia including osteoporosis.  (+info)

TY - JOUR. T1 - Effects of increasing doses of 1α-hydroxyvitamin D2 on calcium homeostasis in postmenopausal osteopenic women. AU - Gallagher, John Christopher G.. AU - Bishop, Charles W.. AU - Knutson, Joyce C.. AU - Mazess, Richard B.. AU - Deluca, Hector F.. PY - 1994/5. Y1 - 1994/5. N2 - This study is the first reported administration of 1α-hydroxyvitamin D2 (1α-OHD2) to human subjects. A total of 15 postmenopausal osteopenic women were given increasing oral doses of 1α-OHD2, beginning with a low dose of 0.5 μg/day. In 15 subjects, the doses were raised at weekly intervals to 1.0, 2.0, 4.0, and 5.0 μg/day, and in 5 of these subjects, the dose was further increased to 8.0 or 10.0 μg/day. Mean urine calcium ± SEM showed a dose-related increase from 134 ± 17 mg/24 h on 0.5 μg/day to 198 ± 21 mg/24 h on 4.0 μg/day (p ,0.05) and to 241 ± 35 mg/24 h on 5.0 μg/day (p ,0.05). No subjects had hypercalciuria (, 350 mg/24 h, the upper limit of the laboratory normal range) at doses less ...
The fellowship in Metabolic Bone Disease is a 1 year clinical research program. Successful completion of the program will enable the fellow to evaluate , diagnose and provide evidence based management of complex metabolic bone diseases. These include osteoporosis in pre and postmenopausal women as well as in men, fibrous dysplasia, sclerotic bone diseases, osteomalacia, osteogenesis imperfecta, hypophosphatasia, X-linked hypophosphatemia , renal osteodystrophy and pagets disease. The fellow will also gain competence in evaluating complex calcium and parathyroid disorders as well as an understanding of how and when to complete genetic testing for calcium disorders as well as metabolic bone diseases. The fellow will attend the American Society of Bone and Mineral Research annual scientific meeting and submit research for presentation at this meeting . The fellowship curriculum is outlined in the American Society of Bone and Mineral Research Primer. It is expected that the fellow will be gain this ...
Bone disease - Metabolic bone disease: The normal function of bone requires an adequate supply of amino acids (the building blocks for proteins) for the synthesis of collagen, the chief component of the organic matrix; of calcium and phosphate for mineralization of the organic matrix; and of other organic compounds and mineral elements. Also, growth, repair, and remodeling of the bone tissue require a precisely regulated supply of hormones, vitamins, and enzymes. Skeletal disease, when it is due to inadequacies in the supply or action of the above essentials, associated with abnormalities outside the skeleton, is termed metabolic; in such cases the entire skeleton is affected.
ASBMR (2008) Chapter 42. Genetics of Osteoporosis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470623992.ch42 ...
The Metabolic Bone Diseases Clinic at Tufts Medical Center in Boston provides care to manage increased risk for fragility fractures due to bone diseases, like osteoporosis.
This clinic treats patients who have metabolic bone diseases - thin bones, thick bones, soft bones, brittle bones and irregular bones. These diseases are caused by problems with mineral metabolism, nutrition, and some genetic diseases. In addition to the above list, we see patients with many kinds of diseases, including:
ASBMR (2008) Chapter 9. Animal Models: Allelic Determinants for BMD, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470623992.ch9 ...
In recent years there has been an increase in the diagnosis of Metabolic Bone disease in hedgehogs and it is a life-threatening syndrome. While the
Metabolic bone diseases are disorders of bone strength, usually caused by abnormalities of minerals (such as calcium or phosphorus), vitamin D, bone mass or
Searching for osteopenia or are you wondering, What is osteopenia? Learn about osteopenia treatments and osteopenia symptoms from Dr. Weil.
Results Data from the first fifteen babies is presented.. Using an ALP cut-off of 400 IU/L to define osteopenia, babies with increased ALP, tended to have a higher PTH (p = 0.07), with mean PTH,7.9 pmol/L being associated with bone disease. Hypophosphatemia (Phosphate,1.5 mmol/l), a known risk factor, was significantly associated with hyperparathyroidism (p = 0.005). PTH and TmP-GFR were inversely correlated. Plasma calcium remained unchanged and within normal range. ...
Mild cases can be treated by proper diet. Dusting salad and insects with a high-quality calcium and D3 supplement is the most effective. The best one on the market right now is Rep-Cal Calcium with Vit.D. Make sure the greens you are using are nutritious and not calcium binding (refer to my list of appropriate fruits and vegetables).. Install a new mercury vapor UVB bulb. Whenever possible, expose your bearded dragon to unfiltered natural sunlight under supervision.. Severe MBD results in rubbery bones and eventually, death. If you suspect that your dragon has MBD, get him/her to the vet as soon as possible.. ...
Ventilatory drive at risk: Surgery in the region of the cervicomedullary junction and upper cervical spine may result in reduced respiratory drive. There may also be pre-existing respiratory compromise due to interstitial lung disease or restrictive ventilation that has developed as a result of a thoracic deformity. Either creates an additional risk factor for respiratory complications during recovery. The child should be monitored in an intensive care or a high-dependency (step-down) facility in the immediate postoperative period. ...
Significant difference (p,0.001) is noted between phosphate-treatment and untreated groups for both GA and BW: Median 27weeks and 929g for treated subjects versus 29.6weeks and 1343g if untreated. In the phosphate-treatment group, ALP levels improved (mean pre-treatment414U/l and post-treatment264U/l, p=0.0006) and difference in phosphate levels were also significant with p=0.003. Between phosphate-treatment group versus untreated group, differences were insignificant for ALP (p=0.05) and phosphate levels (p=0.09), though this may reflect insufficient subsequent MBD screens (treatment group, n=15 versus untreated group, n=7). ...
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Veterinary Manual was first published in 1955 as a service to the community. The legacy of this great resource continues as the Merck Veterinary Manual in the US and Canada and the MSD Manual outside of North America.. ...
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.. ...
From the author of the popular Clinical Chemistry medical student textbook. Although there are many competing texts on clinical chemistry, the vast majority concentrate on the technology; this book concentrates on the clinical. Ideally suited for preparat.
My osteopenia has worsened since my bone scan 2 years ago. Id love to hear from others who are dealing with this. I do plan to start walking more,...
Osteopenia is an early stage of bone loss which can eventually lead to Osteoporosis. Learn the symptoms, diagnosis & treatments for Osteopenia at Apollo Hospitals.
Since weve been covering vitamin D lately, I thought wed discuss some of the metabolic bone diseases caused by D deficiency in children and adults, like osteomalacia, aka rickets in children. Accord
The values of calcium content of foods in the table are not to be taken as remotely absolute, this is one set of figures taken from Fowler, M. (1986) Metabolic bone disease in Zoo & Wild Animal Medicine 2nd edition. There are others and they all vary depending who takes them, where they come from and which lab tests, they should be regarded as indicative of trends only.. ...
Chapter 15 The locomotor and nervous systems Introduction It is convenient to consider these systems in the same chapter. Although the diseases that affect them may show little or no overlap, there are obvious functional links. This chapter is mainly devoted to the clinical biochemistry of metabolic bone disease, articular disease and muscle disease. Numerous…
Osteopenia is a condition involving low bone mass. This means that a persons bones are not as strong as they should be and may be more likely to break.
Femoral neck osteopenia refers to a decrease in bone density in the top part of the femur where it connects to the hip, explains the University of Maryland. The condition can lead to weakening of the...
Osteopenia is the health condition characterized by bone density being lower than normal peak density, but not low enough for osteoporosis to be used in describing it. Bone density is the measurement of how strong and dense the bones are. This is the forum for discussing anything related to this health condition
Osteopenia is the condition in which bone density is somewhat less than a standard young person of the same sex, and is best treated with natural approach.
Objective: The aim of the study was to determine the effect of nesfatin-1 on bone properties in female rats in the conditions of developing osteopenia induced by ovariectomy (OVX). Material and methods: The experiment was performed on 21 female Wistar rats assigned to 3 groups receiving...
My doctor prescribed Fosamax for osteopenia. I took the stuff for about 6 years, and each of my bone density test results were a little worse than the previous ...
Hello everyone, Im back after several years of not having a computer. Im posting in this section because Ive opted not to pursue surgery. I have developed osteopenia and my curve has been stable in the upper 40s lower 50s depending on who reads the radiographs. I couldnt keep up with posting after my computer fried. I was too cheap to buy a new one since I could do my essential tasks from my phone. My HMO hospital hired a new scoliosis surgeon whom I was not impressed with. In his
Hello everyone, Im back after several years of not having a computer. Im posting in this section because Ive opted not to pursue surgery. I have developed osteopenia and my curve has been stable in the upper 40s lower 50s depending on who reads the radiographs. I couldnt keep up with posting after my computer fried. I was too cheap to buy a new one since I could do my essential tasks from my phone. My HMO hospital hired a new scoliosis surgeon whom I was not impressed with. In his
Hello! First, Id like to express my appreciation for your very informative website! I am a healthy 62 yr old woman with osteopenia and mild arthritic
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Whats old may be new again - at least when it comes to the prevention of fractures in postmenopausal women with low bone mineral density.. A study published in the December 20 issue of the New England Journal of Medicine has provided evidence that doses administered once per 18 months of Reclast (zoledronate), a drug that first received U.S. Food and Drug Administration approval in the early 2000s, may help reduce the risk for fractures among women 65 years and older with osteopenia, a precursor to osteoporosis, the progressive bone-eroding condition that affects an estimated 12 million Americans, according to the International Osteoporosis Foundation (IOF). The IOF estimates that more than 30 million U.S. adults (roughly 80 percent of them women) have osteopenia that will likely progress to the more severe form of the condition as they age.. More fractures occur in women with osteopenia than occur in those with osteoporosis, yet no treatment has been demonstrated to be effective in this ...
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Osteopenia and osteoporosis are very similar conditions, but one is more severe than the other. Both mean a decrease in bone density, but osteopenia is
The investigators hypothesis is that secondary causes of bone loss are prevalent in patients with breast and prostate cancer, and those patients with se
Question - Having pain in hip joint. X-rays results showed some osteopenia. Recommended calcium and vitamin D. Remedy?. Ask a Doctor about diagnosis, treatment and medication for Osteopenia, Ask a General & Family Physician
Osteoporosis is a metabolic bone disease that results in decreased bone density or softening of the bones. It is the leading cause of bone fractures in older adults. This number is expected to increase as the population continues to age. It affects both men and women. There are many causative factors to Osteoporosis however; there ...
Osteoporosis: Osteoporosis, disease characterized by the thinning of bones, with a consequent tendency to sustain fractures from minor stresses. Osteoporosis is the most common metabolic bone disease, and its name literally means
My expertise is in the area of skeletal tissue biology. I have studied skeletal biology for more than 30 years and have broad knowledge across many areas in the field, including metabolic bone disease and orthopedic-related diseases. I have carried out numerous preclinical assessments of pharmacological compounds as they relate to safety and efficacy in the treatment of fracture and osteoporosis. I have expertise in skeletal tissue structure and the histomorphometric assessment of skeletal tissues. I was among the first four labs in the United States to develop in vitro osteoblast cultures and helped to establish the standard time dependent sequence of osteogenic differentiation in vitro. My laboratory also was one of four to initially isolate the proteins and clone the major extracellular matrix proteins of bone. I have served on the NIH IRG for Orthopedics, NASA review panels for skeletal tissue biology and the DOD review panels for orthopedic related research.. ...
While most people experience some loss of bone mass as they age, osteopenia and osteoporosis are not inevitable parts of the aging process.
Our board-certified endocrinologists, certified diabetes educators and support staff provide the best diabetes care, combining specialized medical care, diabetes education and nutritional counseling. The center also provides comprehensive, expert care for other endocrine and metabolic diseases, including thyroid disease, osteoporosis, metabolic bone disease, menopause, pituitary-gland disorders and other gland disorders. Your support will make a profound a lasting impact on the health of our diabetic community. In addition to broadening diabetes management through outreach to patients, much needed equipment can be purchased to help those in need. This includes retinal eye cameras, Glucometers, Hemoglobin A1C testing machines, blood pressure cuffs and more. ...
Osteopenia,lower bone density puts you at a higher risk of developing osteoporosis eventually and is often associated with aging.
We believe that every child deserves to live an active lifestyle with hope for a bright future. Thats why we are so steadfast in treating children with brittle bone disease or osteogenesis imperfecta (OI), a genetic disorder that encourages regular fractures and a lifetime of surgeries, casts and periods of immobility. Our goal is to increase the quality of life of children with OI through compassionate care, advanced medical options and continued research aimed at a cure.
In 1990 the bone condition called osteopenia - slight thinning of the bones - didnt exist. Today all over America women are diagnosed with osteopenia and given medication. This is the story of how a drug companys marketing efforts changed the definition of a disease and created a new category of people who saw themselves as needing treatment. Katie Benghauser was diagnosed with osteopenia and takes Fosamax.
The triad of Phemister refers to three features seen classically with tuberculous arthropathy: juxta-articular osteopaenia/osteoporosis peripheral osseous erosions gradual narrowing of joint space
Maria recently posted a wonderful review article about treatments for osteopenia/osteoporosis which indicated that biophosphanates actually make bones
Osteopenia treatment in Tarzana, CA. Osteopenia, the precursor to osteoporosis, can signal bone density loss long before it turns severe.
Kirk Hamilton interviews Dr. Leslie Shen an Associate Professor of Pathology at Texas Tech University Health Sciences Center in Lubbock, Texas. She is the co-author of a paper entitled Effect Of Green Tea and Tai Chi on Bone Health in Postmenopausal Osteopenic Women: A 6-Month Randomized Placebo-Controlled Trial, in the journal Osteoporosis International published in July of 2011. Originally from Taiwan, Dr. Shen has now spent over 2 decades studying how and why some Eastern... ...
Background: Autoclaving rodent diets is common in laboratory animals, but autoclaving increases the formation of dietary advanced glycation end-products (AGE). We studied the effect of autoclaved (AC) diet alone or in combination with a diet high in bioavailable phosphorus on biochemistries of chronic kidney disease-mineral and bone disorder (CKD-MBD), intestinal gene expression, and oxidative stress. Methods: Male CKD rats (Cy/+) and normal littermates were fed 1 of 3 diets: AC 0.7% phosphorus grain-based diet for 28 weeks (AC); AC diet for 17 weeks followed by non-autoclaved (Non-AC) 0.7% phosphorus casein diet until 28 weeks (AC + Casein); or Non-AC diet for 16 weeks followed by a Non-AC purified diet until 30 weeks (Non-AC + Casein). Results: AC diets contained ~3× higher AGEs and levels varied depending on the location within the autoclave. Rats fed the AC and AC + Casein diets had higher total AGEs and oxidative stress, irrespective of kidney function. Kidney function was more severely
As osteopenia and osteoporosis deteriorate physical functions, the person becomes less capable of walking and the risk of injuries from a fall increases. An injury from a fall may lead to fracture and hospitalization. As a result, deterioration of osteopenia and osteoporosis causes loss of physical functions even to the point of death. Thus, effective solutions are to be developed (Shahin et al., 2010). One way of preventing and controlling osteopenia and osteoporosis is an exercise therapy to improve the bone density. For example, a type of training that induces physical stress to osseous tissues such as weight or load bearing exercise is recommended. This type of training delays the reduction of bone density and even increases bone mass (Rittweger et al., 2000). Bone mass is an index that reflects the level of bone density. It is not only an important element for diagnosis of osteopenia and osteoporosis but also a predictive factor for the determine the risk of fracture. A bone density test is ...
Results Patients were mostly women (96.4%) and the mean age was 55.6 ± 10.6 years. The mean follow-up duration of RA was 8.8 ± 4.3 years. At initial visit, 9.1% of patients had a past history of steroid use for diseases other than RA. Rheumatoid factor was positive in 330 of 531 patients (62.1%) and anti-CCP antibodies in 138 of 206 patients (67%). The mean duration between the initial visit and the first BMD screening was 32.7 ± 40.2 months and the prevalence of osteoporosis was 31.7% at screening (95% confidence interval (CI) 27.6 to 36.1). Estimated transition time to osteoporosis was 72 months (95% CI 36 to 90) for patients with normal BMD, 62 months (95% CI 28 to 126) for patients with mild osteopenia, 34 months (95% CI 16 to 60) for patients with moderate osteopenia, and 17 months (95% CI 10 to 21) for patients with severe osteopenia. The adjusted odds ratio (OR) for osteoporosis at initial BMD testing was high for older age (OR 1.066, 95% CI 1.029 to 1.105, p , 0.0001), past steroid ...
ABSTRACT. The term metabolic bone disease encompasses an unrelated group of systemic conditions that impact on skeletal collagen and mineral metabolism. Their asymptomatic progression leads to advanced skeletal debilitation and late clinical manifestation. This article provides a brief overview of advances in the understanding of the pathogenesis of rickets, osteomalacia and age-related osteoporosis.. ...
2000-5000 IU/kg) 2. Prolapsed Organs 3. Metabolic Bone Disease Turtles fed primarily organ meats (liver, heart) or pure muscle (beef, pork, chicken) will develop metabolic bone disease and other nutritional problems. Rx. Vit D3 parenteral and diet correction with suppliments. 4. Shell Rot Usually secondary to the turtle spending all of its time in the water or water which is of poor quality Infectious Diseases 1. Bacterial Disease Debilitated chelonians are vulnerable to respiratory diseases caused by bacteria. Aquatic turtles with lung disease will frequently float in the water asymmetrically or have difficulty surfacing or submerging Septic cutaneous ulcerative disease (SCUD) is a problem most frequently observed in feshwater aquatic turtles like sliders and cooters. The causative agent is Citrobacter fruendii, a Gram-negative rod. Affected animals may present with deep skin ulcers in a variety of locations. Turtles are prone to both superficial and deep mycoses. There are several reports in ...
Mammalian focal adhesion proteins Pinch1 and Pinch2 regulate integrin activation and cell-extracellular matrix adhesion and migration. Here, we show that deleting Pinch1 in osteocytes and mature osteoblasts using the 10-kb mouse Dmp1-Cre and Pinch2 globally (double KO; dKO) results in severe osteopenia throughout life, while ablating either gene does not cause bone loss, suggesting a functional redundancy of both factors in bone. Pinch deletion in osteocytes and mature osteoblasts generates signals that inhibit osteoblast and bone formation. Pinch-deficient osteocytes and conditioned media from dKO bone slice cultures contain abundant sclerostin protein and potently suppress osteoblast differentiation in primary BM stromal cells (BMSC) and calvarial cultures. Pinch deletion increases adiposity in the BM cavity. Primary dKO BMSC cultures display decreased osteoblastic but enhanced adipogenic, differentiation capacity. Pinch loss decreases expression of integrin β3, integrin-linked kinase (ILK), ...
Females: Females The use of LHRH agonists in women may cause a loss of bone mineral density. Following two years treatment for early breast cancer, the average loss of bone mineral density was 6.2% and 11.5% at the femoral neck and lumbar spine respectively. This loss has been shown to be partially reversible at the one year off treatment follow-up with recovery to 3.4% and 6.4% relative to baseline at the femoral 5 neck and lumbar spine respectively although this recovery is based on very limited data. In patients receiving this product for the treatment of endometriosis, the addition of hormone replacement therapy (a daily oestrogenic agent and a progestogenic agent) has been shown to reduce bone mineral density loss and vasomotor symptoms. This product should be used with caution in women with known metabolic bone disease. this productmay cause an increase in uterine cervical resistance, which may result in difficulty in dilating the cervix. Currently, there are no clinical data on the effect ...
2016 Foja, Sabine; Hoffmann, Katrin; Auw-Haedrich, Claudia; Reinhard, Thomas; Rupprecht, Andreas; Gruenauer-Kloevekorn, Claudia (2016): Identification of two novel mutations in the cornea-specific TGFBI gene causing unique phenotypes in patients with corneal dystrophies. In: International ophthalmology 36 (6), S. 867-873. DOI: 10.1007/s10792-016-0216-5. Job, Florian; Mizumoto, Shuji; Smith, Laurie; Couser, Natario; Brazil, Ashley; Saal, Howard, Patterson, Melanie; Gibson Margaret I.; Soden, Sarah; Miller, Neil; Thiffault, Isabelle; Saunders, Carol; Yamada, Shuhei; Hoffmann, Katrin; Sugahara, Kazuyuki; Farrow, Emily (2016): Functional validation of novel compound heterozygous variants in B3GAT3 resulting in severe osteopenia and fractures: expanding the disease phenotype. In: BMC medical genetics 17 (1), S. 86. DOI: 10.1186/s12881-016-0344-9. Kouz, Karim; Lissewski, Christina; Spranger, Stephanie; Mitter, Diana; Riess, Angelika; Lopez-Gonzalez, Vanesa; Lüttgen, Sabine; Aydin, Hatip; von ...
2016 Foja, Sabine; Hoffmann, Katrin; Auw-Haedrich, Claudia; Reinhard, Thomas; Rupprecht, Andreas; Gruenauer-Kloevekorn, Claudia (2016): Identification of two novel mutations in the cornea-specific TGFBI gene causing unique phenotypes in patients with corneal dystrophies. In: International ophthalmology 36 (6), S. 867-873. DOI: 10.1007/s10792-016-0216-5. Job, Florian; Mizumoto, Shuji; Smith, Laurie; Couser, Natario; Brazil, Ashley; Saal, Howard, Patterson, Melanie; Gibson Margaret I.; Soden, Sarah; Miller, Neil; Thiffault, Isabelle; Saunders, Carol; Yamada, Shuhei; Hoffmann, Katrin; Sugahara, Kazuyuki; Farrow, Emily (2016): Functional validation of novel compound heterozygous variants in B3GAT3 resulting in severe osteopenia and fractures: expanding the disease phenotype. In: BMC medical genetics 17 (1), S. 86. DOI: 10.1186/s12881-016-0344-9. Kouz, Karim; Lissewski, Christina; Spranger, Stephanie; Mitter, Diana; Riess, Angelika; Lopez-Gonzalez, Vanesa; Lüttgen, Sabine; Aydin, Hatip; von ...
Inclusion Criteria:. Postmenopausal at least 5 years; Screening bone mineral density more than or equal to 2.5 S.D.s below the mean for young adults at the lumbar spine or femoral neck.. Exclusion Criteria:. Metabolic bone disease other than osteoporosis; Taking approved medications for osteoporosis; Have had a recent osteoporotic fracture (within 1 year) and/or have a bone mineral density more than 4.5 S.D.s below the mean for young adults at the lumbar spine or femoral neck. ...
Medical Director, Johns Hopkins Metabolic Bone Center. Expertise, Disease and Conditions: Endocrinology, Metabolic Bone Disease, Nutrition, Osteoporosis. Research Interests: The role of nutrition and environmental factors in bone health, The role of... [more]. ...
Journal of Osteoporosis is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working on the diagnosis, prevention, treatment and management of osteoporosis and other metabolic bone diseases. The journal publishes research articles, review articles, as well as clinical studies related to the biology, physiology, and pathology of bone and muscle.
Journal of Osteoporosis is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working on the diagnosis, prevention, treatment and management of osteoporosis and other metabolic bone diseases. The journal publishes research articles, review articles, as well as clinical studies related to the biology, physiology, and pathology of bone and muscle.
Osteoporosis is a progressive metabolic bone disease, which is characterized by decrease in bone mineral density, mass, bone calcium loss from bones. This leads to reduced bone strength, increasing the fragility and an increase in the risk of fractures. The most vulnerable are the vertebrae and the femur. Breaks can occur after minor trauma or even without getting hurt, so-called spontaneous fractures can happen. This is a mute disease, begins insidiously, without any symptoms and is usually revealed only when there is a break of some bones. Thats why they call it the silent thief of bones. Sometimes the first symptoms occur like a pain in the bones, joints, muscles, but we usually do not think of osteoporosis as a possible cause ...
Osteoporosis is a progressive metabolic bone disease, which is characterized by decrease in bone mineral density, mass, bone calcium loss from bones. This leads to reduced bone strength, increasing the fragility and an increase in the risk of fractures. The most vulnerable are the vertebrae and the femur. Breaks can occur after minor trauma or even without getting hurt, so-called spontaneous fractures can happen. This is a mute disease, begins insidiously, without any symptoms and is usually revealed only when there is a break of some bones. Thats why they call it the silent thief of bones. Sometimes the first symptoms occur like a pain in the bones, joints, muscles, but we usually do not think of osteoporosis as a possible cause ...
We offer comprehensive care and support for those with osteoporosis or metabolic bone disease. The Dr. David Hanley Osteoporosis Centre Calgary supplies education for clients, the community and healthcare providers including information about: diagnosis, prevention, treatment, information on exercise classes, latest clinical practice guidelines and more.
We offer comprehensive care and support for those with osteoporosis or metabolic bone disease. The Dr. David Hanley Osteoporosis Centre Calgary supplies education for clients, the community and healthcare providers including information about: diagnosis, prevention, treatment, information on exercise classes, latest clinical practice guidelines and more.
Osteoporosis, a chronic, progressive disease of multifactorial etiology (see Etiology), is the most common metabolic bone disease in the United States. It has been most frequently recognized in elderly white women, although it does occur in both sexes, all races, and all age groups.
Do you own a lizard, a parakeet, a sugar glider? Then you should know about metabolic bone disease (MBD) aka (nutritional secondary hyperparathyroidism) and how to prevent it. Reptiles, birds and … ...
In metabolic bone diseases, the alterations in fibrillar level bone-material quality affecting macroscopic mechanical competence are not well-understood quantitatively. Here, we quantify the fibrillar level deformation in cantilever bending in a mouse model for hereditary rickets (Hpr). Microfocus in-situ synchrotron small-angle X-ray scattering (SAXS) combined with cantilever bending was used to resolve nanoscale fibril strain in tensile- and compressive tissue regions separately, with quantitative backscattered scanning electron microscopy used to measure microscale mineralization. Tissue-level flexural moduli for Hpr mice were significantly (p|0.01) smaller compared to wild-type (~5 to 10-fold reduction). At the fibrillar level, the fibril moduli within the tensile and compressive zones were significantly (p|0.05) lower by ~3- to 5-fold in Hpr mice compared to wild-type mice. Hpr mice have a lower mineral content (24.2±2.1Cawt.% versus 27.4±3.3Ca wt.%) and its distribution was more heterogeneous
Loss of bone density, called osteopenia when mild and osteoporosis when severe is becoming more and more common as our population ages and becomes more sedentary. It is also often seen in young people with Chronic Fatigue, Fibromyalgia or pain. Although drug companies mostly promote expensive (and sometimes toxic) medications to both patients and physicians, the good news is
Researchers in the UC Division of Endocrinology, Diabetes & Metabolism are recognized for excellence in the fields of endocrine autoimmunity, metabolic bone disease and diabetes.
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History of thrombophlebitis, thrombosis, thromboembolic disorders. Cerebro- or cardiovascular disease. Diabetes. Hypertension. Conditions aggravated by fluid retention. Renal or hepatic dysfunction. Monitor bilirubin and hepatic enzymes during and for 2 months after treatment is discontinued. Metabolic bone diseases associated with hypercalcemia. Use effective contraception.. ...
TY - JOUR. T1 - Multifunctional p62 Effects Underlie Diverse Metabolic Diseases. AU - Long, Min. AU - Li, Xing. AU - Li, Li. AU - Dodson, Matthew. AU - Zhang, Donna. AU - Zheng, Hongting. PY - 2017. Y1 - 2017. N2 - p62, a protein capable of binding both ubiquitin and autophagy substrates, is well established as a key regulator in cancer and neurodegenerative diseases. Recently, there has been accumulating evidence that p62 is also a pivotal regulator in metabolic diseases, such as obesity, T2DM, NAFLD, metabolic bone disease, gout and thyroid disease. This review summarizes the emerging role of p62 on these diseases by considering its functional domains, phenotypes in genetically modified animals, clinically observed alterations, and its effects on downstream metabolic signaling pathways. At the same time, we highlight the need to explore the roles played by p62 in the gastrointestinal environment and immune system, and the extent to which its elevated expression may confer protection against ...
A turtle shell is made of two parts: the plastron and carapace. Both are covered with scutes. Retained scutes (dysecdysis), metabolic bone disease, and trauma are common diseases of the shell.
Osteopenia and osteoporosis are increasingly reported in HIV-infected patients, and appear to be more frequent than in general population. However, pathogenesis remains unclear, and published studies still give non concordant results.. We therefore started a prospective study, to assess the potential role of ARV in the occurrence of osteopenia and osteoporosis. BMD evolution over a 2-years period of follow-up, will be compared between patients starting ARV therapy, and subjects without HAART (no indication of treatment). A correlation between BMD and several factors will be looked at (see below).. This study with individual direct benefice, is conducted in 3 outpatients clinics (Strasbourg, Colmar, Mulhouse) in collaboration with the rheumatologic teams. 60 patients are planned to be included over a 3-years inclusion period ...
Bisphosphonates (BPs) are a group of well-established medicines that are applied in the development of metabolic bone disorder-related treatments. of bone tissue has the potential to tackle the bone lost that occurs, such as, due to degenerative, medical, or traumatic processes.2 In addition, there is the need to accelerate the healing of large bone fractures and to treat established nonunion problematic fractures.2 With this context, a variety of therapeutic medicines are being evaluated in combination with tissue-engineering methods for bone regeneration.3,4 This evaluate article is focused on the application of bisphosphonates (BPs) in BTE. BPs are well-established medicines that are used in SB-408124 the development of metabolic bone disorder-related therapies, such as osteoporosis and Pagets disease, tumour-induced hyperkalaemia, and inflammation-related bone loss.5C7 Although the use of BPs for BTE is in its initial methods, increasing evidence on the advantages SB-408124 of BPs in ...
A Multicenter Open-label Extension Study to Assess the Long-term Safety and Efficacy of KAI-4169 (also known as AMG 416) in the Treatment of Chronic Kidney Disease-Mineral and Bone Disorder in Patients with Secondary ...
Serrapeptase supports treatment of Osteoporosis and Osteopenia immensely as it clears out all of the inflammation, mucus and dead tissue in the body.
Regarding scheduling, or to reach your doctors office: Phone: (410) 955-3663. To send records, labs or other documents: Fax: (410) 367-2042. Mailing address (please do not mail items to the clinic):. Division of Endocrinology, Diabetes & ...
I have osteopenia but suffered a right femur break, with IM Nailing in September 2018 ….51 weeks later, in late August 2018, I had to have the surgery re-done due to delayed union from wrong size Nail. After that surgery it was discovered I had a stress fracture in my […]
Daar is n bietjie slytasie in die rug met n effense kromming na regs (thoracic spondylosis). Die x-strale wys dat die been aan die verdun is (underlying osteopenia). X-strale is te onsensitief om osteoporose te diagnoseer en n beendigtheid ondersoek is nodig om dit te diagnoseer. Jou dokter kan jou vir een stuur. Die ander kommentaar se maar net dat jy bronchitis onder lede het ...
Ortman, L.F., Hausmann, E. and Dunford, R.G. (1989) Skeletal osteopenia and residual ridge resorption. Journal of Prosthetic Dentistry, 61, 321-325. doi10.1016/0022-3913(89)90137-6
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Bone mass peaks in your 20s, and you begin to lose about 0.5 percent per year after the age of 40. If steps are not taken to combat this loss, decreased bone mineral density (osteopenia) can result. W
Other common causes include metabolic bone diseases (e.g. Paget's disease of bone), post-Perthes deformity, osteomyelitis, and ... Coxa vara is also seen in Niemann-Pick disease. Congenital coxa vara[edit]. Presence at birth is extremely rare and associated ... It can also occur when the bone tissue in the neck of the femur is softer than normal, causing it to bend under the weight of ... This may either be congenital or the result of a bone disorder. The most common cause of coxa vara is either congenital or ...
Rosen CJ (2008-11-18). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. John Wiley and Sons. pp. 168 ... Bone[edit]. Main article: Bone scintigraphy. For example, the ligand methylene-diphosphonate (MDP) can be preferentially taken ... September 2007). "Bone metastases of differentiated thyroid cancer: impact of early 131I-based detection on outcome". Endocrine ... By chemically attaching technetium-99m to MDP, radioactivity can be transported and attached to bone via the hydroxyapatite for ...
Rosen, Clifford J. (2008-11-18). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. John Wiley and Sons ... Bone[edit]. Main article: Bone scintigraphy. For example, the ligand methylene-diphosphonate (MDP) can be preferentially taken ... By chemically attaching technetium-99m to MDP, radioactivity can be transported and attached to bone via the hydroxyapatite for ... Redistribution indicates the existence of coronary steal and the presence of ischemic coronary artery disease.[4] ...
SI: Metabolic bone disease. 32 (5): 639-656. doi:10.1016/j.beem.2018.05.006. ISSN 1521-690X. PMID 30449546. Glasdam, Sidsel- ... This can be caused by diabetes insipidus, renal disease, hypothalamic dysfunction, sickle cell disease, and certain drugs. The ... chronic kidney disease, liver disease, treatment with thiazide diuretics, psychogenic polydipsia, syndrome of inappropriate ... Magnesium is mostly found in the bones and within cells. Approximately 1% of total magnesium in the body is found in the blood ...
Wronski TJ, Morey ER (1982-01-01). "Skeletal abnormalities in rats induced by simulated weightlessness". Metabolic Bone Disease ... high-fat diets induces low bone mineral density and reduces bone formation in rats". Journal of Bone and Mineral Research. 25 ( ... Since exercise increases bone quantity, reduces MAT and increases expression of markers of fatty acid oxidation in bone, MAT is ... During aging, bone quantity declines and fat redistributes from subcutaneous to ectopic sites such as bone marrow, muscle, and ...
Avioli, Louis V.; Krane, Stephen M. (2013). Metabolic Bone Disease, Volume 2. Academic Press. p. 520. ISBN 9781483267920. Tomar ... Chalkstick fractures are particularly common in Paget's disease of bone, and osteopetrosis. It is also seen in cases of fused ... Chalkstick fractures are fractures, typically of long bones, in which the fracture is transverse to the long axis of the bone, ... A healthy long bone typically breaks like a hard woody stick as the collagen in the matrix adds remarkable flexibility to the ...
and other metabolic bone diseases. He has published over 400 scholarly articles and has delivered numerous prestigious ... He is the Director of the Centre for Bone and Periodontal Research and also holds the position of Senior Scientist at the ... He has been Director of the Centre for Advanced Bone and Periodontal Research, as well as Director of the Calcium Research ... He received the Lawrence G. Raisz Award (inaugural) of the American Society for Bone and Mineral Research (ASBMR) in 2010, the ...
Metabolic Bone Disease and Related Research. 5 (4): 206. doi:10.1016/0221-8747(84)90034-1. ISSN 0221-8747. Frootko, N. J. (1985 ... In 1984 Frootko, working with James Triffitt (now Emeritus Professor of Bone Metabolism in Oxford), was able to demonstrate new ... bone formation in human demineralised allograft ossicles used to reconstruct the ossicular chain. Unfortunately this and all ... using allografts were abandoned in 1987 because of the potential risk of transmission of HIV and Creutzfeldt-Jakob disease from ...
Brickley, Megan; Ives, Rachel (2008). The Bioarchaeology of Metabolic Bone Disease. Burlington: Elsevier. pp. 41-44. ISBN ... The leaves are rich in vitamin C, which cures this deficiency disease resulting from a lack of fresh vegetables in the diet. ... Packer, Lester; Fuchs, Jürgen (1997). Vitamin C in health and disease. New York: M. Dekker. pp. 11-17. ISBN 978-0824793135. ... about a disease suffered by Roman soldiers in Germany. Their symptoms resemble those of scurvy, and Pliny recommends a Herba ...
... the iguana develops Metabolic Bone Disease (MBD). Metabolic Bone Disease causes soft bones, stunted growth, permanent bone ... and subsequently will develop metabolic bone disease which is fatal if not treated. In some locales, iguanas are considered ... "Identification and treatment of metabolic bone disease". Melissa Kaplan's Herp Care Collection. anapsid.org. Retrieved 2007-06- ... deformities, frequent broken bones, loss of limbs and ultimately, death. Although they will consume a wide variety of foods if ...
Page 117 in Barbara N. W. Weissman (2009). Imaging of Arthritis and Metabolic Bone Disease. Elsevier Health Sciences. ISBN ... The distances between the bones in the ankle are normally as follows: Talus - medial malleolus : 1.70 ± 0.13 mm Talus - tibial ... but most of the span of the Ahlbäck system focused at various degrees of bone defect or loss, and it is therefore less useful ... The Journal of Bone and Joint Surgery. American Volume. 96 (14): 1145-1151. doi:10.2106/JBJS.M.00929. ISSN 0021-9355. PMC ...
Imaging of arthritis and metabolic bone disease. Philadelphia, PA: Mosby/Elsevier. p. 679. ISBN 978-0-323-04177-5. Retrieved 5 ... Polyuria is usually viewed as a symptom or sign of another disorder (not a disease by itself), but it can be classed as a ... Mariani, Laura (2007). "The Renal Manifestations of Thyroid Disease". Journal of the American Society of Nephrology. 23 (1): 22 ... hyperthyroidism hypopituitarism Conn's disease hyperglycaemia Circulation congestive heart failure cardiorespiratory disease ...
Pharmaceuticals in the treatment of bone and joint disease, respiratory disease and cardiovascular and metabolic disease ...
... hypercalcemia associated with tumors or metabolic bone disease; porphyria. Contraindications: Mammary tumors; estrogen- ... Dosage: 80 mg every 4-8 weeks I.M. Precautions/Warnings: Biliary tract disease; endometriosis; uterine fibroma; ...
Metabolic bone disease (MBD) is a collective term for several common diseases/illnesses that can be fatal for bearded dragons. ... Hypocalcemia is most often tied to metabolic bone disease. Low levels of calcium can result in twitching muscles, or seizures. ... Bearded dragons require UVB to enable Vitamin D3 synthesis and to prevent illnesses like metabolic bone disease. Vitamin D3 is ... Maintaining a diet that consists of enough calcium is crucial to avoiding hypocalcemia as well as metabolic bone disease. ...
... a major risk-factor for veno-occlusive disease in the liver after allogeneic bone marrow transplantation". Blood. 92 (12): 4568 ... Jeffrey K. Aronson (21 February 2009). Meyler's Side Effects of Endocrine and Metabolic Drugs. Elsevier. pp. 217, 253, 275. ... Wiegratz, Inka; Kuhl, Herbert (2006). "Metabolic and clinical effects of progestogens". The European Journal of Contraception ... The enzymes involved in these metabolic processes are 5α- and 5β-reductase as well as 3α- and 3β-hydroxysteroid dehydrogenase ( ...
CS1 maint: discouraged parameter (link) Metabolic Bone and Stone Disease. BEC Nordin, AG NEED, HA Morris: Churchill Livingstone ... The three-phase bone scan may be the most sensitive method of detecting early heterotopic bone formation. However, an ... About every third patient who has total hip arthroplasty (joint replacement) or a severe fracture of the long bones of the ... It is not clear exactly what this means, because these patients do not develop heterotopic bone formation. It has been ...
Rosen, Clifford J. (2008-11-18). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. John Wiley and Sons ... Imaging is not as reliable in patients with multiglandular parathyroid disease. In addition, size limitation of the abnormal ...
Metabolic Bone Disease in Historical Captive Primates". Int J Primatol. 36 (2): 398-411. doi:10.1007/s10764-015-9831-7. S2CID ... "BBC Four - Secrets of Bones". Bbc.co.uk. 2017-02-07. Retrieved 2017-02-27. CS1 maint: discouraged parameter (link) Ben Garrod ... Coates, Liz (25 January 2014). "TV stardom beckons for Great Yarmouth 'bone man' Ben Garrod - Norfolk evolutionary biologist ... in addition to his own six-part series called Secrets of Bones on BBC Four. He has also presented numerous short films on the ...
Feeding kaka has resulted in metabolic bone disease in kaka chicks. In 2016 80% of the kaka chicks being monitored by the ... Hunter, S.A.; Alley, M.R.; Lenting, B.M. (2017). "Metabolic Bone Disease in North Island Kaka, Nestor meridionalis ... Wellington City Council died from this disease. There have also been instances of kaka nesting in the roofs of houses. BirdLife ...
... an overlooked contribution to metabolic bone disease". International Journal of Epidemiology. 32 (3): 340-1. doi:10.1093/ije/ ... Maternal deficiencies may be the cause of overt bone disease from before birth and impairment of bone quality after birth. The ... Occasionally surgery may be done to fix bone deformities. Genetic forms of the disease typically require specialized treatment ... Rickets is a condition that results in weak or soft bones in children. Symptoms include bowed legs, stunted growth, bone pain, ...
... they can experience severe pain and/or deformities from diseases such as metabolic bone disease. Along with UVB, a blue tegu ... a calcium deficiency can lead to metabolic bone disease, which can be fatal. Predators of tegus include cougars, jaguars, ... a single frontal bone and a single parietal bone. Biomechanical analyses suggest the posterior processes of the parietal might ... Hoff, Gerald (6 December 2012). Diseases of Amphibians and Reptiles. Springer Science & Business Media. pp. 643-. ISBN 978-1- ...
The metabolic bone disease is a product of lack of UVB light and calcium. Natural light gives off vitamin D3. This vitamin is ... 14, 52-53). Addition issues that can occur in tame dragons are vitamin A deficiency and metabolic bone disease. Vitamin A ... The disease can cause soft bones and muscle cramping (Langerwerf, 2006, p. 54-55). According to Langerwerf, signs of an ...
Eggs laid by a female whose calcium reserves are low occasionally exhibit signs of congenital metabolic bone disease, such as ... An unbalanced diet containing insufficient calcium can quickly lead to metabolic bone disease (MBD). Though the export of wild ...
August 2015). "Evidence for Chronic Kidney Disease-Mineral and Bone Disorder Associated With Metabolic Pathway Changes". ... Due to the lower iPTH levels achieved by the use of this drug, it is possible that adynamic bone disease could occur at levels ... Etelcalcetide is used for the treatment of secondary hyperparathyroidism in people with chronic kidney disease (CKD) on ...
2019), who interpret their findings as indicative of the occurrence of a metabolic bone disease in the Cretan deer population, ... Evidence for a devastating metabolic bone disease in an insular Pleistocene deer". International Journal of Paleopathology. 24 ... 2019). A study on the morphology of the limb bones of caviomorph rodents from the Miocene Santa Cruz Formation of Patagonia, ... 2019). A study assess the usefulness of the scapholunar (one of the carpal bones) for determining ecology and habitat of ...
Pyramiding may also be a visible sign of metabolic bone disease (MBD) in tortoises. Once pyramiding has occurred, it cannot be ... The bone of the shell consists of both skeletal and dermal bone, showing that the complete enclosure of the shell probably ... The bones of the shell are named for standard vertebrate elements. As such the carapace is made up of 8 pleurals on each side, ... Some of those bones that make the top of the shell, carapace, evolved from the scapula rami of the clavicles along with the ...
"Metabolic bone disease ad central retinal degeneration in a kitten due to nutritional inadequacy of an all-meat raw diet". J ... Detection of diseases[edit]. Feline diseases such as FeLV, FIV, and feline heartworm can be detected during a routine visit to ... Infectious diseases[edit]. An infectious disease is caused by the presence of pathogenic organisms such as viruses, bacteria, ... Intestinal Bowel Disease causes frequent vomiting and weight loss in cats. Similar to Crohn's disease in humans, a cat's ...
This article is about a skin disease common during adolescence. For other acneiform skin diseases, see Acne (disambiguation). ... Kuhl H (1997). "Metabolische Effekte der Östrogene und Gestagene" [Metabolic effects of estrogens and progestogens]. Der ... and decreased bone mineral density, make its use for male acne impractical in most cases.[114][115][116] Pregnant and lactating ... Disease Primers. 1: 15033. doi:10.1038/nrdp.2015.33. PMID 27227877.. *^ a b "Frequently Asked Questions: Acne" (PDF). U.S. ...
Mandel SJ, Brent GA, Larsen PR (September 1993). "Levothyroxine therapy in patients with thyroid disease". Annals of Internal ... as thyroid hormones may cause an acute adrenal crisis by increasing the metabolic clearance of glucocorticoids.[20] For oral ... suppression of TSH values below normal values will frequently cause cardiac side-effects and contribute to decreases in bone ... For older people (over 50 years old) and people with known or suspected ischemic heart disease, levothyroxine therapy should ...
Normally, the bone age is the same as the biological age but for some people, it is older. For many people with advanced bone ... Chronic illnesses, malnutrition, endocrine, metabolic disorders or chromosomal anomalies are characterized by proportionate ... chronic kidney disease, being small for gestational age at birth, Prader-Willi syndrome, Wiedemann-Steiner syndrome, or other ... When the cause is unknown, it is called idiopathic short stature.[5] Short stature can also be caused by the bone plates fusing ...
"Metabolic syndrome pathophysiology: The role of adiposetissue". Nutrition, Metabolism and Cardiovascular Diseases. 17 (2): 125 ... Bind bones and other tissues to each other. Alpha polypeptide chains. tendon, ligament, skin, cornea, cartilage, bone, blood ... Mixed connective tissue disease - a disease of the autoimmune system, also undifferentiated connective tissue disease. ... Special connective tissue consists of reticular connective tissue, adipose tissue, cartilage, bone, and blood.[8] Other kinds ...
The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... Hourigan CS (2006). "The molecular basis of coeliac disease". Clin Exp Med (Review). 6 (2): 53-59. doi:10.1007/s10238-006-0095- ... Glia come in several types, which perform a number of critical functions, including structural support, metabolic support, ... Frappaz D, Mornex F, Saint-Pierre G, Ranchere-Vince D, Jouvet A, Chassagne-Clement C, Thiesse P, Mere P, Deruty R (1999). "Bone ...
"Microbial Ecology in Health and Disease. 30 (sup1): 1535737. doi:10.1080/16512235.2018.1535737. PMC 6225515. PMID 30425610.. ... Bacteria in the large intestine further break down the material.[1][2] Feces contain a relatively small amount of metabolic ... These are studied to determine the diet and health of the people who produced them through the analysis of seeds, small bones, ... For other types of body waste, see metabolic waste. For the American punk rock band, see Fecal Matter (band). ...
Dent's disease. *X-linked nephrogenic diabetes insipidus. Bone/tooth. *AMELX Amelogenesis imperfecta ... Metabolic. *Amino acid: Ornithine transcarbamylase deficiency. *Oculocerebrorenal syndrome. *Dyslipidemia: Adrenoleukodystrophy ... Symptoms of disease are more severe in males, who are generally diagnosed in early childhood. Children afflicted by CLS display ... The prevalence of CLS is uncertain due to the rarity of the disease, but CLS is estimated to affect between 1 in 50,000 and 1 ...
... and metabolic diseases (diabetes, cystinosis). Structural abnormalities of the kidneys are identified with imaging tests. These ... activated vitamin D supplements and phosphate binders may be required to counteract the effects of kidney failure on bone ... and systemic diseases that occur as a result of kidney disease, such as renal osteodystrophy and hypertension. A physician who ... the study of normal kidney function and kidney disease, the preservation of kidney health, and the treatment of kidney disease ...
A common example of pleiotropy is the human disease phenylketonuria (PKU). This disease causes mental retardation and reduced ... This linkage is further evidenced by the fact that two of the genes, HAO1 and BMP2, affecting medullary bone (the part of the ... Metabolic supermice. *Polygene. References[edit]. *^ a b Paaby, Annalise B.; Rockman, Matthew V. (2016-11-15). "The many faces ... "Complications and Treatments , Sickle Cell Disease". CDC. Retrieved 2016-11-11.. *^ a b c d "Marfan Syndrome". National ...
Paterson, Sue (December 17, 2007). Skin Diseases of Exotic Pets. Blackwell Science, Ltd. pp. 74-79. ISBN 9780470752432. .. ... The new section will however contain cartilage rather than bone, and will never grow to the same length as the original tail. ... The allantois (8) is a sac that collects the metabolic waste produced by the embryo. The amniotic sac (10) contains amniotic ... Hellebuyck, Tom; Pasmans, Frank; Haesbrouck, Freddy; Martel, An (July 2012). "Dermatological Diseases in Lizards". The ...
This is due to the accumulation of oxidative damage to DNA by aging and cellular metabolic activity and the shortening of ... Ginaldi, L.; M.F. Loreto; M.P. Corsi; M. Modesti; M. de Martinis (2001). "Immunosenescence and infectious diseases". Microbes ... which is the organ essential for T-cell maturation following the migration of precursor cells from the bone marrow. This age- ... This has been implicated in the increasing frequency and severity of diseases such as cancer, chronic inflammatory disorders, ...
A component of bones (see apatite), cells, in energy processing, in DNA and ATP (as phosphate) and many other functions Red ... Authors: Nielsen, Forrest H. USDA, ARS Source: Modern nutrition in health and disease / editors, Maurice E. Shils ... et al.. ... Suggested function from deprivation effects or active metabolic handling, but no clearly-identified biochemical function in ... Required for processing ATP and for bones Spinach, legumes, nuts, seeds, whole grains, peanut butter, avocado[22] ...
The main adverse effects of diuretics are hypovolemia, hypokalemia, hyperkalemia, hyponatremia, metabolic alkalosis, metabolic ... By contrast, loop diuretics promote a significant increase in calcium excretion.[8] This can increase risk of reduced bone ... and certain kidney diseases. Some diuretics, such as acetazolamide, help to make the urine more alkaline and are helpful in ... Bakhireva LN, Barrett-Connor E, Kritz-Silverstein D, Morton DJ (June 2004). "Modifiable predictors of bone loss in older men: a ...
Bone mass is affected by muscles forces and their loads to the bone structure. The strength and density of the bone is directly ... Add to these factors disease and cardiac and respiratory illness. Eccentric training enables the elderly, and those with the ... Howlett K., T. Keniston, A. Grassl, A. Olsson, C. Eidem, and D.J. McCann, January 2011 [AN INITIAL ASSESSMENT OF THE METABOLIC ... Total body eccentric training can raise resting metabolic rate by about 9 percent, with the greatest magnitude in the first two ...
Some chemicals generate metabolic byproducts that could be used for diagnosis, but detection of these byproducts may not be ... 2008) Agricultural lung diseases. Environ Health Perspect 108:705-12. Hlastala MP, Ralph DD, Babb AL, Influence of gas physical ... This agent also causes respiratory tract lesions, bone marrow depression, and eye damage, the epithelial tissues of these ... Secondary effects of sulfur mustard exposure lead to chronic lung diseases such as chronic bronchitis. A common exposure ...
Lidwell M C, "Cardiac Disease in Relation to Anaesthesia" in Transactions of the Third Session, Australasian Medical Congress, ... Most commonly, the generator is placed below the subcutaneous fat of the chest wall, above the muscles and bones of the chest. ... that detect changes in the patient's physical activity and automatically adjust the pacing rate to fulfill the body's metabolic ... sinus node disease (SND) or sick sinus syndrome. Where the problem is atrioventricular block (AVB) the pacemaker is required to ...
Bone density scans are recommended to monitor the bone mineral density.[13] ... "Orphanet Journal of Rare Diseases. 6 (Jun 17): 41. doi:10.1186/1750-1172-6-41. PMC 3143089. PMID 21682876.. ... Metabolic. *Amino acid: Ornithine transcarbamylase deficiency. *Oculocerebrorenal syndrome. *Dyslipidemia: Adrenoleukodystrophy ... Laitinen EM, Hero M, Vaaralahti K, Tommiska J, Raivio T (August 2012). "Bone mineral density, body composition and bone ...
"Pathophysiology: Principles of Disease. Computing Centre, Slovak Academy of Sciences: Academic Electronic Press. Archived from ... As with animals, plants attacked by insects or other pathogens use a set of complex metabolic responses which lead to the ... The bone marrow of a normal healthy adult produces more than 100 billion neutrophils per day, and more than 10 times that many ... Main article: Plant disease resistance § Immune system. Members of every class of pathogen that infect humans also infect ...
Other diseases[edit]. Studies examining the effects of vitamin C intake on the risk of Alzheimer's disease have reached ... "Nutrition and Metabolic Insights. 9: 25-30. doi:10.4137/NMI.S39764. PMC 4915787. PMID 27375360.. ... bone pain, bleeding gums, susceptibility to bruising, poor wound healing, and finally fever, convulsions and eventual death.[2] ... "Journal of Alzheimer's Disease. 29 (4): 711-26. doi:10.3233/JAD-2012-111853. PMC 3727637. PMID 22366772.. ...
"Overview of samarium sm 153 lexidronam in the treatment of painful metastatic bone disease". Rev Urol. 6 Suppl 10 (Suppl 10): ... molecular breakages and molecular re-arrangements such as a change of stacking structures as well as cellular metabolic ... Radiation therapy is used to treat early stage Dupuytren's disease and Ledderhose disease. When Dupuytren's disease is at the ... valvular heart disease, coronary artery disease, heart arrhythmia and peripheral artery disease. Radiation-induced fibrosis, ...
Joint WHO/FAO expert consultation (2003). Diet, Nutrition and the Prevention of Chronic Diseases (PDF). who.int. Geneva: World ... "metabolic advantage."[16][19] In 2017 Kevin Hall, a NIH (National Institutes of Health) researcher hired to assist with the ... bone health and cancer risk.[23] One low quality meta-analysis reported that adverse effects could include "constipation, ... "Nutrition, Metabolism, and Cardiovascular Diseases. 24 (4): 337-43. doi:10.1016/j.numecd.2013.12.008. PMC 4351995. PMID ...
Anti-germ theory of diseasesEdit. Virchow did not believe in the germ theory of diseases, as advocated by Louis Pasteur and ... Virchow broke his thigh bone on 4 January 1902, jumping off a running streetcar while exiting the electric tramway. Although he ... Virchow discovered the clinical syndrome which he called ochronosis, a metabolic disorder in which a patient accumulates ... Virchow's disease, leontiasis ossea, now recognized as a symptom rather than a disease ...
Viral disease. Notes and references[edit]. *^ "Archived copy" (PDF). Archived (PDF) from the original on 2016-08-03. Retrieved ... Møller M; El Maghrabi R; Olesen N; Thomsen VØ (November 2004). "Safe inoculation of blood and bone marrow for liquid culture ... For bacterial identification, the use of metabolic or enzymatic characteristics are common due to their ability to ferment ... For example, some diseases such as measles employ a strategy whereby it must spread to a series of hosts. In these forms of ...
Mouth diseases include tongue diseases and salivary gland diseases. A common gum disease in the mouth is gingivitis which is ... They are made of a bone-like material called dentin, which is covered by the hardest tissue in the body-enamel.[8] Teeth have ... It can also arise as a result of other gastrointestinal diseases such as coeliac disease. Coeliac disease is an autoimmune ... Crohn's disease is a common chronic inflammatory bowel disease (IBD), which can affect any part of the GI tract,[45] but it ...
... bone mineral density after weight loss was higher when normalized for body weight;[10] reduced bone mineral density is also ... In the 2000s, the US National Institute on Aging and the National Institute of Diabetes and Digestive and Kidney Diseases ... Benedict is known for the Harris-Benedict equation used to measure metabolic rate. ... "Journal of Bone and Mineral Research. 28 (9): 1857-1865. doi:10.1002/jbmr.1980. PMC 3749267. PMID 23671010.. ...
HRT is not a life-saving drug, nor does it cure any disease. HRT has been prescribed to improve one's quality of life. Doctors ... NSAIDs, anticholinergics, haemostatic drugs, antifibrinolytics, Hormone Replacement Therapy (HRT), bone regulators, beta- ... metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these ... It describes plant-based drugs to counter diseases.[31] The earliest foundations of ayurveda were built on a synthesis of ...
"Diseases and Conditions. Mayoclinic.com. 2008-10-11. Archived from the original on 2008-09-13. Retrieved 2009-10-17.. ... This diet was designed in order to mimic many of the effects that starvation has on the metabolic functioning of the body. By ... broken bones and burns and more likely to die in a fatal automobile crash.[27] ... The main genetic cause of frontal lobe epilepsy is an autosomal dominant disease called Autosomal Dominant Nocturnal Frontal ...
Bridges, M.; Jones, A. M. E.; Bones, A. M.; Hodgson, C.; Cole, R.; Bartlet, E.; Wallsgrove, R.; Karapapa, V. K.; Watts, N.; ... These natural chemicals most likely contribute to plant defence against pests and diseases, and impart a characteristic bitter ... "Successful herbivore attack due to metabolic diversion of a plant chemical defense". Proceedings of the National Academy of ...
However, the external opening of the ear still lies at the base of the jaw.[15] The platypus has extra bones in the shoulder ... "Platypus Fungal Disease". Department of Primary Industries and Water, Tasmania. 29 August 2008. Archived from the original on 7 ... "Energetics of Swimming by the Platypus Ornithorhynchus anatinus: Metabolic Effort Associated with Rowing" (PDF). The Journal ... The disease (termed mucormycosis) affects only Tasmanian platypuses, and has not been observed in platypuses in mainland ...
... disease including cardiovascular disease, cancer, diabetes and chronic lung disease (Shah, 2014). ... Level of functional or metabolic efficiency of a living being. This article is about the human condition. For other uses, see ... Nutrients help build and strengthen bones, muscles, and tendons and also regulate body processes (i.e. blood pressure). Water ... "Centers for Disease Control and Prevention. Retrieved 7 August 2012.. *^ "Occupational Safety and Health Administration". U.S. ...
Metabolic bone disease. Definition. Metabolic bone disease describes a diverse group of disorders of bone metabolism, most ... Mass spectrometric quantitation of AGEs and enzymatic crosslinks in human cancellous bone *Shoutaro Arakawa ... Anabolic agents represent a novel approach to improving bone quality in people with osteoporosis. This Review discusses ...
Metabolic bone disease: The normal function of bone requires an adequate supply of amino acids (the building blocks for ... Skeletal disease, when it is due to inadequacies in the supply or action of the above essentials, associated with abnormalities ... Also, growth, repair, and remodeling of the bone tissue require a precisely regulated supply of hormones, vitamins, and enzymes ... outside the skeleton, is termed metabolic; in such cases the entire skeleton is affected. ...
Our aim is to enhance understanding of disease mechanisms and establish means for early diagnosis, prevention and treatment in ...
... and researchers working in the field of bone health and disease, Primer on the Metabolic Bone Diseases and Disorders of Mineral ... Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism The authoritative reference to bone diseases and ... 38 Scintigraphy and PET in Metabolic Bone Disease 302. Lorenzo Nardo, Paola A. Erba, and Benjamin L. Franc. 39 Bone ... The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone ...
... , Critical Illness Related Metabolic Bone Disease, Osteoporosis Secondary to ICU ... Metabolic Bone Disease Following ICU Admission. Metabolic Bone Disease Following ICU Admission Aka: Metabolic Bone Disease ... Search other sites for Metabolic Bone Disease Following ICU Admission NLM Pubmed Google Websites Google Images QuackWatch ... These images are a random sampling from a Bing search on the term "Metabolic Bone Disease Following ICU Admission." Click on ...
Diseases Clinic at Tufts Medical Center in Boston provides care to manage increased risk for fragility fractures due to bone ... Metabolic Bone Diseases Clinic. Overview. The Metabolic Bone Diseases Clinic at Tufts Medical Center provides cutting edge care ... Throughout your time in our care, the doctors of the Metabolic Bone Diseases Clinic will take the time to get to know you so ... Title(s): Director, Metabolic Bone Diseases Clinic; Assistant Professor, Tufts University School of Medicine. Department(s): ...
Each fellow will cover the monthly Metabolic Bone Disease Clinic, the weekly Metabolic Bone Disease Conference and the weekly ... The Metabolic Bone Disease Fellowship program within the combined orthopaedic, medical and radiology bone consortium represents ... The HSS Metabolic Bone Disease Fellowship is designed to provide the participant with an ongoing, in-depth experience in the ... The Metabolic Bone Disease Fellows are the primary surgeons on service cases under the supervision of the attending staff and ...
Metabolic Bone Diseases - 2017. Metabolic Bone Diseases - 2017. 18 January 2017 - 20 January 2017 ...
Metabolic bone disease is an abnormality of bones caused by a broad spectrum of disorders. Most commonly these disorders are ... For example, genetic or hereditary hypophosphatemia may cause the metabolic bone disorder osteomalacia. Although there is ... osteoporosis osteomalacia (adults) & rickets (children) osteitis fibrosa cystica Pagets disease of bone pyramiding (turtles) ... replacement of phosphate often corrects or improves the metabolic bone disorder. ...
Discover how Cleveland Clinics Metabolic Bone Disease & Endocrine Calcium Center helps streamline the evaluation and treatment ... Metabolic Bone Disease & Endocrine Calcium Center Metabolic Bone Disease & Endocrine Calcium Center ... Elevated markers of bone turnover. The Metabolic Bone Disease & Endocrine Calcium Center may also provide evaluation and ... The Metabolic Bone Disease & Endocrine Calcium Center addresses problems associated with the regulation of the bodys bone, ...
B. Lalor, T.B. Counihan; Metabolic Bone Disease in Heavy Drinkers. Clin Sci (Lond) 1 September 1982; 63 (3): 43P. doi: https:// ... LncRNA MALAT1 gene polymorphisms in coronary artery disease: a case-control study in a Chinese population Biosci Rep (March, ... Relation between Hepatic Alcohol Dehydrogenase Activity and the Ascorbic Acid in Leucocytes of Patients with Liver Disease J. ... Altered HDL metabolism in metabolic disorders: insights into the therapeutic potential of HDL ...
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition , ... Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition. ... in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & ...
Genetics of Osteoporosis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc ... Copyright © 2008 American Society for Bone and Mineral Research. All rights reserved. ...
Metabolic bone disease, amphibians. As metabolic bone disease advances, pathologic fractures of the long bones are readily seen ... Eye Diseases and Disorders Generalized Conditions Immune System Integumentary System Management and Nutrition Metabolic ... Eye Diseases and Disorders Generalized Conditions Immune System Integumentary System Management and Nutrition Metabolic ... From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health ...
Myopathy and Metabolic Bone Disease. Gerald Stern, M.R.C.P.; Roger Smith, M.R.C.P. ... A retrospective clinical and biochemical study of 136 patients with metabolic bone disease has shown that 6 out of 91 patients ... Stern G, Smith R. Myopathy and Metabolic Bone Disease.. Ann Intern Med. ;68:1190-1191. doi: 10.7326/0003-4819-68-5-1190_3 ... Myopathy may occur as a presenting complaint in the absence of symptoms or signs of bone disease and may deceptively simulate ...
Evaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients. The safety and scientific validity of this ... Evaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients. Actual Study Start Date :. December 12, ... Diagnostic Test: measurements to evaluate metabolic bone disease Diagnostic Test: standard care Not Applicable ... Diagnostic Test: measurements to evaluate metabolic bone disease The participants will be evaluated for a) Mineral metabolism: ...
Signs of metabolic bone disease include hard knobs in the long bones of the legs, bumps along the vertebral column of the back ... Metabolic bone disease (MBD) is an umbrella term that covers a number of disorders related to the weakening of the bone or ... The result is a well-functioning system, with calcium restored to and, in the case of growing animals, added to the bone matrix ... Advanced cases of MBD include all the above signs plus constipation, anorexia and fractured bones. Severely deficient reptiles ...
... and clinical studies related to the identification of disease markers, the elucidation of their role and mechanism, as well as ... Disease Markers is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... their application in the prognosis, diagnosis and treatment of diseases. ... Postnatal Changes in Humerus Cortical Bone Thickness Reflect the Development of Metabolic Bone Disease in Preterm Infants. ...
Disease-associated impairment/dysfunction of stem cell populations is prominent in chronic metabolic and inflammatory diseases ... Mesenchymal stem cells Diabetes Bone marrow Osteogenesis Adipogenesis Metabolic disease This is a preview of subscription ... 2020) Model for Studying the Effects of Chronic Metabolic Disease on Endogenous Bone Marrow Stem Cell Populations. In: Guest P ... Model for Studying the Effects of Chronic Metabolic Disease on Endogenous Bone Marrow Stem Cell Populations. ...
Metabolic Bone Disease symptoms Started by squirrelfriend, 02-05-2007 08:23 AM 6 Pages •. 1 2 3 ... 6 ... Pycnogenol: supports mineralization of the bones Started by Diggies Friend, 07-13-2017 10:17 PM ... MBD (Metabolic Bone Disease). * NEW to the Forum? Remember to REFRESH your screen often to see the latest responses to your ...
... uric acid and metabolic syndrom were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad. ... PubMed journal article Chronic kidney disease associated with decreased bone mineral density, ... "Chronic Kidney Disease Associated With Decreased Bone Mineral Density, Uric Acid and Metabolic Syndrome." PloS One, vol. 13, no ... Chronic Kidney Disease Associated With Decreased Bone Mineral Density, Uric Acid and Metabolic Syndrome. PLoS ONE. 2018;13(1): ...
Metabolic bone diseases: Osteoporosis and osteopetrosis. Osteoporosis, which is characterized by low bone mineral density and ... We propose a method to predict the therapeutic effects of various drugs against metabolic bone diseases in silico using V-Bone ... Measuring bone turnover markers and bone mineral density is the conventional noninvasive method to evaluate bone metabolic ... couplings modeled in V-Bone relate bone adaptation to mechanical loading and reproduce metabolic bone diseases such as ...
Despite a high prevalence of metabolic bone disease, less than half of chronic pancreatitis patients were assessed. Not ... PTU-027 Is metabolic bone disease routinely tested for in chronic pancreatitis?. ... Chronic pancreatitis is associated with metabolic bone disease which increases the risk of fragility fractures. The National ... The aim of this study was to assess compliance with metabolic bone assessment in patients with chronic pancreatitis, assess the ...
Metabolic Bone Disease (MBD for short) is one of the most prolific nutritional disorders seen in captive herptiles. It is a ... Metabolic Bone Disease in Captive Reptiles What is MBD?. ​. Metabolic Bone Disease (MBD for short) is one of the most prolific ... Paw Talk - Pet Forums , Other Pets , Reptile & Amphibian Discussion > Metabolic Bone Disease in Captive Reptiles ... Perhaps the most well-known of these metabolic bone disorders is rickets which is characterised by the bowing of the long bones ...
Biochemical markers for bone turnover for the clinical assessment of metabolic bone disease. Endocrin Metab Clin North Am 1990; ... The tissue pathological features of metabolic bone disease. Orthop Clin North Am 1984;15:613-29. [ Links ]. ... 6. Jowsey J (ed). Metabolic diseases of bone. Philadelphia: W B Saunders Company; 1977: 229-47. [ Links ]. ... Metabolic diseases affecting bone are generally diagnosed late when patients present clinically with end stage skeletal ...
Metabolic Bone Disease Care Marilyn F. Augustine, M.D. Director, Metabolic Bone Disease Clinic ... The Metabolic Bone Clinic at the University of Rochester Division of Endocrinology focuses on the evaluation and care of ... The bones in our bodies are living tissue. Bone metabolism is affected by factors such as nutrition, exercise, medical ... Abnormalities in bone metabolism can result in bone disorders and imbalance of minerals such as calcium and phosphorus. ...
... in the presence of metabolic bone disease). Hypercalciuria is almost always present, and the value of the simple Sulkowitch ... The salient features of the condition, namely, generalised bone pains, anorexia, polyuria and polydipsia, loss of strength and ... A case of hyperparathyroidism with metabolic bone disease, due to a single parathyroid adenoma, is presented. ... oa Central African Journal of Medicine - Primary hyperparathyroidism with metabolic bone disease * Navigate this Journal ...
Emergency Treatment for Metabolic Bone Disease (updated 3-31-09) Get calcium into the squirrel IMMEDIATELY, not later, not ... Emergency Treatment of Metabolic Bone Disease (MBD) Emergency Treatment for Metabolic Bone Disease (updated 3-31-09). Get ... Re: Emergency Treatment of Metabolic Bone Disease (MBD) hello, my squirrel little nugz just became paralyzed less than 24 hours ... Re: Emergency Treatment of Metabolic Bone Disease (MBD) Was wondering where would I find thetastier block recipe mentioned in ...
Metabolic bone disease Synonym(s): MBD, Nutritional secondary hyperparathyroidism (NSHP), Hypocalcemic metabolic bone disease ... Klaphake E (2010) A fresh look at metabolic bone diseases in reptiles and amphibians. Vet Clin North Am Exotic Anim Pract 13 (3 ... Mader D (2006) Metabolic Bone Diseases. In: Reptile Medicine and Surgery. Ed: Mader D R. Saunders-Elsevier, USA. pp 841-851. ... Nutritional diseases in chameleons, Nutritional diseases in geckos, Nutritional diseases in lizards, Nutritional diseases in ...
Buy Metabolic Bone Disease and Clinically Related Disorders by Louis V. Avioli at TextbookX.com. ISBN/UPC: 9780120687008. Save ... This is the updated Third Edition of the classic reference work on metabolic bone disease. It features the latest advancements ...
  • Based in the Department of Endocrinology, the Metabolic Bone Disease & Endocrine Calcium Center provides superior access to a multidisciplinary team, providing Center-of-Excellence DXA bone density testing and interpretation, on-site laboratory testing, and a fully staffed infusion center for even the most sophisticated testing and drug administration requirements. (clevelandclinic.org)
  • The Metabolic Bone Clinic at the University of Rochester Division of Endocrinology focuses on the evaluation and care of patients with conditions that affect bone and mineral metabolism. (rochester.edu)
  • osteoporosis osteomalacia (adults) & rickets (children) osteitis fibrosa cystica Paget's disease of bone pyramiding (turtles) Osteoporosis is due to causal factors like atrophy of disuse and gonadal deficiency. (wikipedia.org)
  • These include osteoporosis in pre and postmenopausal women as well as in men, fibrous dysplasia, sclerotic bone diseases, osteomalacia, osteogenesis imperfecta, hypophosphatasia, X-linked hypophosphatemia , renal osteodystrophy and paget's disease. (mcmaster.ca)
  • Paget's disease is the second most common bone remodeling disease after osteoporosis, occurring in 1%-2% of white adults older than 55. (aace.com)
  • Identify and manage some of the nosological entities that endocrinologists are called upon for diagnosis and treatment (i.e., normocalcemic hyperparathyroidism, Paget's disease, adult forms of osteogenesis imperfecta, fibrous dysplasia of bone, etc. (endocrine.org)
  • One 15-minute infusion of the intravenous bisphosphonate zolendronic acid more rapidly reduced the biochemical markers of bone turnover in patients with Paget's disease than was seen in a head-to-head comparison with the oral treatment risedronate (95% vs. 75% response rate). (news-medical.net)
  • Paget's disease of bone ), post-Perthes deformity , osteomyelitis , and post traumatic (due to improper healing of a fracture between the greater and lesser trochanter ). (wikipedia.org)
  • Dr. Joy Wu is a board-certified endocrinologist with over 12 years' experience who specializes in treating women and men with osteoporosis and other bone and mineral diseases, including primary hyperparathyroidism, vitamin D deficiency, Paget's disease and fibrous dysplasia. (stanford.edu)
  • When the normal composition of bone tissue is altered by deficient mineralization of the organic matrix, the condition is called rickets in children and osteomalacia in adults. (britannica.com)
  • Perhaps the most well-known of these metabolic bone disorders is rickets which is characterised by the bowing of the long bones such as the femur or humorous along with flaring of the joints. (paw-talk.net)
  • 17. Raubenheimer EJ, van Heerden WFP, Potgieter D. Static and dynamic bone changes in hospitalized patients suffering from rickets - a histomorphometric study. (scielo.org.za)
  • Kwashiorkor-Marasmus syndrome and nutritional rickets - a bone biopsy study. (scielo.org.za)
  • One of the classic diseases that aluminum is linked to is rickets. (mercola.com)
  • Rickets is caused by a deficiency in vitamin D . During growth, human bone is made and maintained by the interaction of calcium , phosphorus , and vitamin D. Calcium is deposited in immature bone (osteoid) in a process called calcification, which transforms immature bone into its mature and familiar form. (faqs.org)
  • However, in order to absorb and use the calcium available in food, the body needs vitamin D. In rickets, the lack of this important vitamin leads to low calcium, poor calcification, and deformed bones. (faqs.org)
  • Historically, rickets plagued the populations of European countries in the northern latitudes-at one time it was called 'the English disease. (faqs.org)
  • This child's bowed legs are a symptom of rickets, a disease resulting from vitamin-D deficiency. (faqs.org)
  • Metabolic bone disease describes a diverse group of disorders of bone metabolism, most commonly caused by abnormalities of minerals (such as calcium or phosphorous) or vitamin D. (nature.com)
  • The authoritative reference to bone diseases and disorders of mineral metabolism, revised and update. (wiley-vch.de)
  • Now in its ninth edition, The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone and mineral health. (wiley-vch.de)
  • The ninth edition provides concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. (wiley-vch.de)
  • The new edition of this invaluable reference expands coverage and includes the most recent developments in the field that help to strengthen its usefulness and ensure that the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism maintains its place as the pre-eminent reference on bone and mineral health. (wiley-vch.de)
  • Written for advanced students, clinicians, and researchers working in the field of bone health and disease, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease. (wiley-vch.de)
  • In the intervention group changes in measures of mineral metabolism (serum calcium, phosphorus, PTH and 25 OH vitamin D levels), changes in bone turnover markers, BMD and bone quality markers will be compared to baseline results. (clinicaltrials.gov)
  • Bone structure and function are maintained by well-regulated bone metabolism and remodeling. (sciencemag.org)
  • We anticipate that these in silico experiments will substantially accelerate research into bone metabolism and remodeling. (sciencemag.org)
  • Thus, it is indispensable to fully elucidate the underlying molecular and cellular mechanisms of bone metabolism and remodeling, from both scientific and clinical viewpoints. (sciencemag.org)
  • Bone metabolism is affected by factors such as nutrition, exercise, medical illnesses and medications, as well as hormones including parathyroid hormone, vitamin D, estrogen, and testosterone. (rochester.edu)
  • Abnormalities in bone metabolism can result in bone disorders and imbalance of minerals such as calcium and phosphorus. (rochester.edu)
  • The term 'metabolic bone disease' encompasses an unrelated group of systemic conditions that impact on skeletal collagen and mineral metabolism. (scielo.org.za)
  • Vitamin D deficiency results in abnormalities in calcium, phosphorous, and bone metabolism. (aace.com)
  • These diseases are caused by problems with mineral metabolism, nutrition, and some genetic diseases. (uw.edu)
  • Metabolic Bone Disease, Volume II describes the clinical disorders of bone and mineral metabolism characterized by elevated levels of circulating parathyroid hormone. (ogmaexpo.com)
  • The goal of this review is to explore clinical associations between peripheral neuropathy and diabetic bone disease and to discuss how nerve dysfunction may contribute to dysregulation of bone metabolism, reduced bone quality, and fracture risk. (nih.gov)
  • In addition, the peripheral nervous system has the potential to regulate bone metabolism directly through the action of local neurotransmitters on bone cells and indirectly through neuroregulation of the skeletal vascular supply. (nih.gov)
  • However, the widespread use of effective ART has coincided with increasing reports of metabolic abnormalities such as impaired glucose metabolism and insulin resistance, lactic acidosis, osteopenia, and dyslipidemia. (thebodypro.com)
  • Her clinical research interests are in the areas of bone metabolism and obesity. (massgeneral.org)
  • My research focuses on the dual fields of bone disease and obesity metabolism. (massgeneral.org)
  • The Metabolic Bone Diseases Clinic at Tufts Medical Center provides cutting edge care to patients with osteoporosis, hyperparathyroidism, and other conditions that weaken bones. (tuftsmedicalcenter.org)
  • A retrospective clinical and biochemical study of 136 patients with metabolic bone disease has shown that 6 out of 91 patients with primary hyperparathyroidism and at least 20 out of 45 patients with osteomalacia developed remediable proximal muscle weakness. (annals.org)
  • A case of hyperparathyroidism with metabolic bone disease, due to a single parathyroid adenoma, is presented. (journals.co.za)
  • A lack of Vitamin D can result in metabolic bone disease (MBD), also known as secondary nutritional hyperparathyroidism or osteoporosis. (nmlc.org)
  • Polymeri A, Giannobile WV, Kaigler D (2016) Bone marrow stromal stem cells in tissue engineering and regenerative medicine. (springer.com)
  • Mangialardi G, Madeddu P (2016) Bone marrow-derived stem cells: a mixed blessing in the multifaceted world of diabetic complications. (springer.com)
  • In other cases, the organic component of the bone tissue is affected, leading to decreased bone strength, as in the case of osteogenesis imperfecta . (wustl.edu)
  • They are used to increase bone density and reduce fracture rates in osteogenesis imperfecta. (ispn.guide)
  • It is most commonly a sequela of osteogenesis imperfecta , Pagets disease , osteomyelitis , tumour and tumour-like conditions (e.g. fibrous dysplasia ). (wikipedia.org)
  • In addition, osteoporosis (age-related loss of bone with tendency to fractures) is traditionally included among the metabolic conditions even though its cause is not known. (britannica.com)
  • In osteomalacia, bone tenderness and pain accompany the slow development of the spontaneous, often symmetric fractures characteristically present in the osteomalacic pelvis and thighbones. (britannica.com)
  • Once the doctors know more about your condition, they will work closely with you to develop a customized treatment plan to optimize bone mass and in turn, reduce fractures and prevent complications. (tuftsmedicalcenter.org)
  • As metabolic bone disease advances, pathologic fractures of the long bones are readily seen on radiographs. (merckvetmanual.com)
  • There is a well-documented increased risk for disordered mineral bone homeostasis in Kidney Transplant Recipients (KTRs) when compared to the general population, leading to a markedly increased risk for fragility fractures and their associated morbidity and mortality. (clinicaltrials.gov)
  • In addition, maintenance of load-bearing function throughout life is important to prevent bone fractures. (sciencemag.org)
  • Chronic pancreatitis is associated with metabolic bone disease which increases the risk of fragility fractures. (ovid.com)
  • Patient demographics, aetiology of chronic pancreatitis, prescription of pancreatic enzyme replacement therapy (PERT), vitamin D levels, DEXA scan result, history of fractures and bone protection medications were noted. (ovid.com)
  • Many of these diseases lead to fractures of the bones, and our goal is to prevent the fractures and to reduce pain in the bones. (uw.edu)
  • When untreated, osteoporosis can lead to fragility fractures, bone deformities and serious disability. (ashe-endo.com)
  • This can lead to weak bones and fractures. (wustl.edu)
  • Two new studies in the May 24 issue of The Archives of Internal Medicine, one of the JAMA/Archives journals, examines methods to accurately classify postmenopausal women with reduced bone mass and identify those with increased risk for future fractures. (news-medical.net)
  • Osteoporosis is a disease characterized by low bone mass associated with the deterioration of microarchitecture, due to an imbalance either in high bone resorption or low bone formation or in both, leading to a high risk of fractures. (bvsalud.org)
  • Osteoporosis, a disease of fragile bones resulting in fractures, will strike 50% of women and 25% of men. (stanford.edu)
  • These treatments make the transplant possible but also make their bones weaker and more prone to fractures which can be a source of significant disability and decreased quality of life for cancer survivors. (stanford.edu)
  • Examples of such abnormalities are dietary deficiency and gastrointestinal, liver, kidney, and hormonal diseases. (britannica.com)
  • Changes in bone tissue due to metabolic abnormalities are classified with regard to the amount and composition of the bone tissue. (britannica.com)
  • The Metabolic Bone Disease & Endocrine Calcium Center team has partnered with their highly skilled Endocrine Surgery colleagues to provide timely, integrated assessment of parathyroid abnormalities with ultrasonography, direct laryngoscopy, and other state of the art testing. (clevelandclinic.org)
  • Additionally, metabolic abnormalities associated with obesity, bariatric surgery and organ transplantation are diagnosed and treated. (clevelandclinic.org)
  • Two cases of rare diseases with abnormalities of X chromosome]. (annals.org)
  • and to evaluate whether treatment of abnormalities in these parameters will improve skeletal health as quantified by bone mineral density (BMD), bone turnover markers (rate of skeletal remodeling) and Osteoprobe (a direct index of bone quality using reference point indentation technology. (clinicaltrials.gov)
  • Diseases that arise from internal (endogenous) causes include hereditary abnormalities (disorders inherited from one or both parents), congenital diseases (disturbances in the development of a normal embryo), allergies (hypersensitive reactions to substances in the environment), endocrine disorders (generally either overfunctioning or underfunctioning of an endocrine gland), circulatory disorders (diseases of the heart and blood vessels), and neoplasms, or tumors (masses of abnormally proliferating cells). (thefreedictionary.com)
  • It is the result of a calcium/phosphorous imbalance in the body and its symptoms include a weakening of the bones, joint abnormalities and reduced nerve transmission. (arkwildlife.co.uk)
  • Metabolic bone diseases are disorders of bone strength usually caused by abnormalities of minerals (such as calcium or phosphorus), vitamin D, bone mass or bone structure, with osteoporosis being the most common. (ashe-endo.com)
  • Distressing morphologic changes in body habitus associated with these metabolic abnormalities are characterized by accumulation of fat in the abdomen (visceral fat compartment) and in the dorsocervical area of the neck, as well as by the depletion of fat in the face, buttocks, and extremities. (thebodypro.com)
  • Furthermore, although some of the metabolic disturbances may be linked to one another, the interconnections among these metabolic abnormalities have yet to be elucidated. (thebodypro.com)
  • The Outi Mäkitie research group studies genetic defects and clinical factors underlying skeletal disorders, with main interests in early-onset primary and secondary osteoporosis, skeletal dysplasias, and vitamin D. Our aim is to enhance understanding of disease mechanisms and establish means for early diagnosis, prevention and treatment in childhood-onset skeletal disorders. (helsinki.fi)
  • With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information accessible for clinical interventions. (wiley-vch.de)
  • In addition to treating patients, she devotes time to clinical research to study the effects of nutritional therapies for improving bone and muscle health. (tuftsmedicalcenter.org)
  • A more uniform and rigorous evaluation of bone and mineral homeostasis,than is afforded to patients under 'normal care', will result in better clinical outcomes in KTRs. (clinicaltrials.gov)
  • Biochemical markers for bone turnover for the clinical assessment of metabolic bone disease. (scielo.org.za)
  • Clinical features and diagnosis of celiac disease. (scielo.org.za)
  • Serial measurements of serum PTH were made from 2 weeks of age and fortnightly to coincide with clinical samples for electrolyte and bone chemistry, until term corrected gestation or discharge. (bmj.com)
  • The fellowship in Metabolic Bone Disease is a 1 year clinical research program. (mcmaster.ca)
  • Clinical endocrinologists worldwide rely on Endocrine Practice, the official journal of the American Association of Clinical Endocrinologists (AACE), to keep them on the leading edge of treatment of patients with endocrine diseases. (aace.com)
  • Building on the success of previous editions, this leading textbook primarily focuses on clinical aspects of the subject, giving detailed coverage of all conditions where clinical biochemistry is used in diagnosis and management - including nutritional disorders, diabetes, inherited metabolic disease, metabolic bone disease, renal calculi and Category: MEDICAL. (ogmaexpo.com)
  • Faculty members present clinical content that incorporate practice guidelines, newly reported research findings, preclinical research and clinical practice patterns from across the field of bone and calcium disorders. (endocrine.org)
  • She performs clinical research at the National Institutes of Health, Bethesda MD in areas of metabolic bone diseases, genetics and adrenal diseases. (hopkinsmedicine.org)
  • Metabolic bone diseases in patients after allogeneic hematopoietic stem cell transplantation: Report from the Consensus Conference on Clinical Practice in chronic graft-versus-host disease. (fredhutch.org)
  • Here, we present a review as part of the German, Austrian, and Swiss Consensus Conference on clinical practice in chronic graft-versus-host disease, held 2009 in Regensburg. (fredhutch.org)
  • Patients should be assessed annually to determine whether they are at increased risk of developing chronic kidney disease based on clinical and sociodemographic factors. (aafp.org)
  • For example, genetic or hereditary hypophosphatemia may cause the metabolic bone disorder osteomalacia. (wikipedia.org)
  • Osteomalacia inadequate mineralisation of the bone. (paw-talk.net)
  • In recent years there has been an increase in the diagnosis of Metabolic Bone disease in hedgehogs and it is a life-threatening syndrome. (arkwildlife.co.uk)
  • In addition, group discussion sessions provide case-based practical strategies on the diagnosis and treatment of patients with osteoporosis and metabolic bone diseases. (endocrine.org)
  • The diagnosis of the bone dysplasias is rarely the province of the pediatric neurosurgeon. (ispn.guide)
  • The SpA population had a median time since diagnosis of 6.6 months and a disease duration of 6.3 years. (nih.gov)
  • This includes guidelines for diagnosis, prevention, and therapeutic options in patients with low bone mass or AVN. (fredhutch.org)
  • After the diagnosis of chronic kidney disease is made, staging based on estimated glomerular filtration rate determines prognosis, evaluation, and management. (aafp.org)
  • it represents an attempt at structural strengthening by thickening of bony trabeculae, but its X-ray appearance may be confused with that of dead bone, retaining its density while adjacent normal bone has become osteopenic. (britannica.com)
  • c)Bone Mineral Density using a Dual energy x-ray absorptiometry which is the standard method by which bone mass is measured clinically. (clinicaltrials.gov)
  • c) Bone Mineral Density using a Dual energy x-ray absorptiometry which is the standard method by which bone mass is measured clinically, we will measure bone mass at the lumbar spine, wrist, hip and total body bone mass at 3, and 18 months. (clinicaltrials.gov)
  • The relationship between decreased bone mineral density (BMD) and chronic kidney disease (CKD) is controversial. (unboundmedicine.com)
  • AU - Pan,Bo-Lin, AU - Loke,Song-Seng, Y1 - 2018/01/10/ PY - 2017/07/26/received PY - 2017/12/22/accepted PY - 2018/1/11/entrez PY - 2018/1/11/pubmed PY - 2018/2/13/medline SP - e0190985 EP - e0190985 JF - PloS one JO - PLoS ONE VL - 13 IS - 1 N2 - OBJECTIVE: The relationship between decreased bone mineral density (BMD) and chronic kidney disease (CKD) is controversial. (unboundmedicine.com)
  • Bone mineral density determinations by dual-energy-x-ray absorptiometry in the management of patients with Marfan syndrome - some factors which affect the measurement. (scielo.org.za)
  • There was decreased bone density with lytic areas in the pelvis and femur, and severe bilateral nephrocalcinosis. (uzh.ch)
  • More than 8 million of the 44 million Americans who have either osteoporosis or low bone mineral density (BMD) are men. (aace.com)
  • We can measure the bone density, and also evaluate bones with other kinds of radiology, blood tests and urine tests. (uw.edu)
  • The objective of this study was to determine the prevalence and risk factors of low bone mineral density (BMD) in patients with spondylarthropathies (SpA) at an early stage of disease. (nih.gov)
  • The outcome measure BMD was defined as (1) osteoporosis, (2) osteopenia, and (3) normal bone density. (nih.gov)
  • Skeletal complications such as osteoporosis or avascular necrosis (AVN) occur frequently in allogeneic recipients with a cumulative incidence of diminished bone mineral density of 24-50% between 2 and 12 months after allo-SCT and a cumulative incidence of AVN in as many as 19% of patients 3 years after allo-SCT. (fredhutch.org)
  • She is currently the Director of the MGH Bone Density Center and Assistant Professor in Medicine at Harvard Medical School. (massgeneral.org)
  • The Metabolic Bone Disease & Endocrine Calcium Center is comprised of a team of expert physician-scientists who specialize in the treatment of a vast number of common and rare bone, calcium and other mineral disorders associated with the regulation of skeletal and parathyroid hormone functions. (clevelandclinic.org)
  • The Metabolic Bone Disease & Endocrine Calcium Center and the Department of Endocrine Surgery continue to collaborate to provide comprehensive pre-surgical assessment, timely surgical intervention, and post-surgical follow up for all patients with parathyroid disease in their care. (clevelandclinic.org)
  • The Metabolic Bone Disease & Endocrine Calcium Center addresses problems associated with the regulation of the body's bone, mineral and hormone functions. (clevelandclinic.org)
  • Endocrine diseases are disorders of the endocrine system . (wikipedia.org)
  • AACE Members devote a significant part of their career to the evaluation and management of patients with endocrine disease. (aace.com)
  • The annual Endocrine Fellows Series: Osteoporosis and Metabolic Bone Diseases is a CME-certified conference of pediatric and adult endocrine fellows held in conjunction with the Santa Fe Bone Symposium (August 3-4,2018) in Santa Fe, New Mexico. (endocrine.org)
  • The Cancer Survivor Clinic is designed to care for children with endocrine diseases related to cancer treatment. (iu.edu)
  • She has been honored with awards from the NIH Director's New Innovator Award, the Endocrine Society, the American Society for Bone and Mineral Research, and the Mary Kay Foundation. (stanford.edu)
  • The download New Techniques in Metabolic Bone Disease of crawl should contact pressed on the limited menopause selection, therapy, the Lexicology computer address of book and ErrorDocument, and a dell of the embryonic newsletter and types for conclusions. (ashoda.fr)
  • We are only accredited the programs about not retaining the download New Techniques in Metabolic Bone Disease to support one-year books( Discussion, beneficial intervention) and we are converted off targets about sure data throughout the repeat. (ashoda.fr)
  • create your free new techniques in metabolic bone disease so polarity not can seek it currently. (medmotion.com)
  • Throughout your time in our care, the doctors of the Metabolic Bone Diseases Clinic will take the time to get to know you so that they can tailor treatment strategies to your needs and lifestyle. (tuftsmedicalcenter.org)
  • Each fellow will cover the monthly Metabolic Bone Disease Clinic, the weekly Metabolic Bone Disease Conference and the weekly Osteoporosis Patient sign-out. (hss.edu)
  • The Osteoporosis & Bone Clinic focuses on the treatment and prevention of a wide range of skeletal issues caused by osteoporosis. (clevelandclinic.org)
  • This clinic treats patients who have metabolic bone diseases - thin bones, thick bones, soft bones, brittle bones and irregular bones. (uw.edu)
  • The Metabolic Bone Clinic is located in the UWMC-Roosevelt, an outpatient facility at 4245 Roosevelt Way N.E. in Seattle's University District. (uw.edu)
  • Please call the Metabolit Bone Clinic at 206-598-BONE (2663) between 8 a.m. and 5 p.m. Monday through Friday (except holidays). (uw.edu)
  • An alteration of one of the steps in bone remodeling starts a cascade of events which includes a shift in the balance between internal and external calcium effector organs, a change in the secretion of parathyroid hormone, calcitonin, and so forth, and ultimately a change in the frequency of activation of new packets of bone remodeling. (elsevier.com)
  • Objective: To compare parathyroid hormone to alkaline phosphatase as a serologic marker for metabolic bone disease (MBD) in preterm infants. (utmb.edu)
  • Calcediol (25-hydroxy-vitamin D3) is converted to Calcetriol (1,25-dihydroxyvitamin D3) which controls the uptake of calcium from the intestines, its reabsorption from the renal tubules and its release from bone. (vetstream.com)
  • Participants with end stage renal disease (ESRD) requiring hemodialysis received a single subcutaneous injection of 210 mg romosozumab on day 1. (clinicaltrials.gov)
  • 5 More than 500,000 Americans were treated for end-stage renal disease in 2007. (aafp.org)
  • The Chronic Kidney Disease Epidemiology Collaboration formula is more accurate than the Modification of Diet in Renal Disease equation or the Cockcroft-Gault equation, and should be used to estimate GFR. (aafp.org)
  • These disorders are to be differentiated from a larger group of genetic bone disorders where there is a defect in a specific signaling system or cell type that causes the bone disorder. (wikipedia.org)
  • Although there is currently no treatment for the genetic condition, replacement of phosphate often corrects or improves the metabolic bone disorder. (wikipedia.org)
  • For example, genetic modification of signaling molecules in vivo has illuminated the molecular mechanisms of bone diseases ( 8 , 9 ). (sciencemag.org)
  • The fellow will also gain competence in evaluating complex calcium and parathyroid disorders as well as an understanding of how and when to complete genetic testing for calcium disorders as well as metabolic bone diseases. (mcmaster.ca)
  • In more rare cases, genetic defects can cause the bones to become very thick but malformed and brittle, as in the case of osteopetrosis . (wustl.edu)
  • Objective To identify the factors that increase risk of metabolic bone disease of prematurity (MBD). (elsevier.com)
  • Background: Metabolic bone disease of prematurity (MBD) is a common problem among preterm infants. (elsevier.com)
  • Disease-associated impairment/dysfunction of stem cell populations is prominent in chronic metabolic and inflammatory diseases, such as type 2 diabetes mellitus (DM) where the multifunctional properties (viability, proliferation, paracrine secretion, multilineage differentiation) of bone marrow resident mesenchymal stem cells (MSCs) can be affected. (springer.com)
  • We have consequently optimized the isolation and culture conditions for impaired/dysfunctional bone marrow MSCs from B6.Cg-Lep ob /J obese prediabetic mice. (springer.com)
  • Morrison SJ, Scadden DT (2014) The bone marrow niche for haematopoietic stem cells. (springer.com)
  • Schatteman GC (2004) Adult bone marrow-derived hemangioblasts, endothelial cell progenitors, and EPCs. (springer.com)
  • Mehrbani Azar Y, Green R, Niesler CU, van de Vyver M (2018) Antioxidant preconditioning improves the paracrine responsiveness of bone marrow mesenchymal stem cells to diabetic wound fluid. (springer.com)
  • Briquet A, Dubois S, Bekaert S, Dolhet M, Beguin Y, Gothot A (2010) Prolonged ex vivo culture of human bone marrow mesenchymal stem cells influences their supportive activity toward NOD/SCID-repopulating cells and committed progenitor cells of B lymphoid and myeloid lineages. (springer.com)
  • Lu L, Song H-F, Zhang W-G, Liu XQ, Zhu Q, Cheng XL et al (2012) Potential role of 20S proteasome in maintaining stem cell integrity of human bone marrow stromal cells in prolonged culture expansion. (springer.com)
  • Bone marrow transplantation is currently recommended only for mucopolysaccharidosis type I (Hurler syndrome). (ispn.guide)
  • Some patients with type II disease (Hunter disease) have been successfully treated with bone marrow transplantation. (ispn.guide)
  • Bone marrow transplantation has to be performed before 2 years of age. (ispn.guide)
  • Key bone techniques that I am utilizing include high-resolution peripheral quantitative computed tomography (HR-pQCT) for the in vivo assessment of bone microarchitecture, microindentation for the estimation of cortical bone material strength properties, and 1H-magnetic resonance spectroscopy for the measurement of marrow adiposity characteristics. (massgeneral.org)
  • Dr. Wu directs a broad basic and translational research program that focuses on skeletal development and the bone marrow hematopoietic niche. (stanford.edu)
  • As a physician scientist, my laboratory is studying stem cells in the skeleton and bone marrow to develop novel regenerative approaches to increase bone quality and strength. (stanford.edu)
  • Patients who undergo bone marrow transplant for different types of cancer are exposed to many treatments such as steroids and whole body radiation. (stanford.edu)
  • it occurs when bone resorption occurs faster than bone formation. (britannica.com)
  • Bone homeostasis can be disrupted by an imbalance between bone resorption and formation due to disuse or sex hormone aberrations, resulting in metabolic bone diseases such as osteoporosis ( 3 , 4 ). (sciencemag.org)
  • Recent advances in molecular and cellular biology have helped identify multiple signaling pathways that regulate osteoclastic bone resorption and osteoblastic bone formation, as well as their relationship to mechanical stress ( 5 - 7 ). (sciencemag.org)
  • MBD can be divided into three categories: Osteoporosis a reduction in bone mass due to dietary deficit or intense bone resorption. (paw-talk.net)
  • Disruption of bone remodelling by diseases such as osteoporosis results in an imbalance between bone formation by osteoblasts and resorption by osteoclasts. (frontiersin.org)
  • The resorption and formation processes are balanced, and remodel approximately 5% of cortical and 20% of trabecular bone each year. (frontiersin.org)
  • This bone mass is then maintained for approximately 20 years until resorption begins to outweigh formation and mass declines. (frontiersin.org)
  • In contrast to remodelling, a homeostatic renewal process where resorption and formation are coupled spatially and temporally, bone modelling defines the shaping or reshaping of bones where osteoblasts and osteoclasts can act independently. (frontiersin.org)
  • Bisphosphonates are medications which reduce the ability of osteoclasts to induce bone resorption and consequently improve the balance between resorption and formation. (bvsalud.org)
  • Localized osteopenia is evident in X-rays of tumours or infections of bone, in osteonecrosis (death of bony tissue), in fracture, and in conditions of diminished mechanical demand. (britannica.com)
  • Making matters worse, the baby will have virtually no symptoms-until their bones fracture. (mercola.com)
  • Metabolic bone disease (MBD) is an umbrella term that covers a number of disorders related to the weakening of the bone or impaired systems function caused by an imbalance in vitamin D3, calcium and phosphorus. (anapsid.org)
  • Individual foods will have varying ratio's higher and lower and an excess of any of these will result in imbalance and potential disease. (arkwildlife.co.uk)
  • Table 1 summarizes the metabolic and morphologic complications associated with HIV infection and ART. (thebodypro.com)
  • Further evaluation should focus on the specific type of kidney disease and on identifying complications related to the disease stage. (aafp.org)
  • Complications of chronic kidney disease (CKD) generally become prevalent when estimated glomerular filtration rate falls below 60 mL/min/1.73 m 2 (stage 3 CKD or greater) and become more common and severe as CKD progresses. (diabetesjournals.org)
  • Bone structure and function are maintained by homeostatic load-adaptive remodeling, which generates sophisticated bone microarchitecture to satisfy mechanical demands. (sciencemag.org)
  • Quite simply stated, vitamin D3 (dietary or derived from exposure to ultraviolet B), calcium (dietary and matter recycled from the bone matrix) and phosphorus (dietary) interact together to perform a number of functions besides bone growth and maintenance, including muscle contractions and blood coagulation. (anapsid.org)
  • The characteristic findings are generalised decalcification with the formation of ""cysts,"" hypochromic anaemia, an elevated serum calcium, a low plasma phosphorus and a high alkaline phosphatase (in the presence of metabolic bone disease). (journals.co.za)
  • Calcitriol allows absorption of calcium and phosphorus in the gut, primarily in the small intestine, and maintains the body's balance of calcium and phosphate through the kidney and bone. (faqs.org)
  • Mechano-biochemical couplings modeled in V-Bone relate bone adaptation to mechanical loading and reproduce metabolic bone diseases such as osteoporosis and osteopetrosis. (sciencemag.org)
  • This is the result of their subclinical progression and the lack of unequivocal biochemical-or radiological techniques to identify bone changes at an early stage. (scielo.org.za)
  • Osteopaenia and osteo-malacia after gastrectomy: interrelations between biochemical markers of bone remodeling, vitamin D metabolites and bone histomorphometry. (scielo.org.za)
  • The associations among metabolic syndrome (MetS), serum uric acid and CKD are also unclear. (unboundmedicine.com)
  • Infants with severe bone disease had a lower birth weight, 21-day serum P, an increased use of glucocorticoids and caffeine, and more likely to have major neonatal morbidities.Conclusion: PTH is an early marker with better sensitivity than ALP in screening for MBD. (utmb.edu)
  • Insufficient protein, caloric, and vitamin intake interferes with bone formation during growth and remodeling, directly because of an inadequate supply for matrix formation and indirectly because of a deficient production of crucial hormones and enzymes. (britannica.com)
  • 13. Lee WT, Jiang J. The resurgence of the importance of vitamin D in bone health. (scielo.org.za)
  • This balance of vitamin D, calcium, and phosphate is essential to the growth and maintenance of bones, especially in children. (faqs.org)
  • Breast milk, a primary source of childhood nutrition , contains very little vitamin D, and infants who are exclusively breastfed are more likely to develop the disease. (faqs.org)
  • This includes a full musculoskeletal exam, a targeted metabolic laboratory work-up, and specific imaging studies. (tuftsmedicalcenter.org)
  • For orthopaedists, emphasis is placed on operative and non-operative management of all problems of musculoskeletal disorders, including diseases of the lumbar spine, trauma, orthopaedic oncology, and degenerative diseases. (hss.edu)
  • Kornicka K, Houston J, Marycz K (2018) Dysfunction of mesenchymal stem cells isolated from metabolic syndrome and type 2 diabetic patients as result of oxidative stress and autophagy may limit their potential therapeutic use. (springer.com)
  • Hunter syndrome (mucopolysaccharidosis type II) is the only X-linker disorder among the more common metabolic bone disorders. (ispn.guide)
  • As the metabolic alterations coinciding with the availability of effective ART are similar to the features seen in the metabolic syndrome ("syndrome X"), one of the major concerns has been the potential for increased cardiovascular morbidity and mortality in this cohort. (thebodypro.com)
  • The combination of these morphologic changes and antiretroviral-associated metabolic derangements has been referred to as the lipodystrophy syndrome ( Figures 1-4 ). (thebodypro.com)
  • 7 , 8 In addition, both the fat accumulation component and the fat depletion component of the syndrome are associated with substantial metabolic dysregulation that may have an impact on long-term cardiovascular morbidity and mortality in HIV-positive patients. (thebodypro.com)
  • Parenteral nutrition is explored, from background, access, and delivery points to formula composition and use in specific conditions, including short bowel syndrome and organ diseases. (barnesandnoble.com)
  • Within the bone field, my ongoing research projects include (1) studying skeletal health after bariatric (weight loss) surgery in obese patients, (2) determining the physiologic mechanisms involved in bone loss after bariatric surgery, and (3) using these insights to guide management of bone health in bariatric surgery patients. (massgeneral.org)
  • She has a special interest in optimizing skeletal health for those at risk of bone loss from glucocorticoid treatment, cancer therapies, or organ transplant. (stanford.edu)
  • Any disease or condition that causes pain and affects the normal functioning of the jaw joint and its muscles is referred to as a temporomandibular joint disorder. (medwonders.com)
  • This may either be congenital or the result of a bone disorder. (wikipedia.org)
  • Metabolic bone disease (MBD) is a common complication of chronic kidney disease (CKD). (ogmaexpo.com)
  • A more recent article on chronic kidney disease is available. (aafp.org)
  • Chronic kidney disease affects an estimated 27 million adults in the United States, and is associated with significantly increased risk of cardiovascular disease and stroke. (aafp.org)
  • Other risk factors include cardiovascular disease, family history of chronic kidney disease, and ethnic and racial minority status. (aafp.org)
  • Chronic kidney disease (CKD) affects an estimated 27 million adults in the United States and is associated with increased mortality, morbidity, and health care costs. (aafp.org)
  • Risk of chronic kidney disease (CKD) progression, frequency of visits, and referral to nephrology according to glomerular filtration rate (GFR) and albuminuria. (diabetesjournals.org)
  • When the amount of bone is lower or higher than normal, the conditions are termed, respectively, osteopenia and osteosclerosis. (britannica.com)
  • These findings emphasize the need for more alertness for osteoporosis and osteopenia in spondylarthropathy patients at an early stage of the disease. (nih.gov)
  • Additionally, we work closely with other Departments to provide care for patients who have complex metabolic bone disease. (tuftsmedicalcenter.org)
  • Successful completion of the program will enable the fellow to evaluate , diagnose and provide evidence based management of complex metabolic bone diseases. (mcmaster.ca)
  • Widespread but hardly ever truly generalized, osteosclerosis occurs in osteopetrosis ( marble bone disease ) and in Paget disease . (britannica.com)
  • Osteopetrosis excessive mineralisation of the bone whereby bone is thickened yet still remains fragile. (paw-talk.net)
  • The aim of this study was to assess compliance with metabolic bone assessment in patients with chronic pancreatitis, assess the prevalence of abnormal DEXA scans and the impact of this assessment on appropriate management. (ovid.com)
  • Despite a high prevalence of metabolic bone disease, less than half of chronic pancreatitis patients were assessed. (ovid.com)
  • 9 Among participants in the Multicenter AIDS Cohort Study (MACS) and the Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM), the prevalence of increased abdominal fat was quite high even among HIV-negative participants. (thebodypro.com)
  • Osteitis deformans, or Pagets disease of the bone, is the deformity of the bone. (medwonders.com)
  • This often progresses from erosion and osteitis to ossification, resulting in telltale radiological signs of periosteal new bone formation. (medscape.com)
  • Myopathy may occur as a presenting complaint in the absence of symptoms or signs of bone disease and may deceptively simulate primary muscular disorders. (annals.org)
  • Metabolic bone disease can result in some very severe symptoms. (nmlc.org)
  • Symptoms include severe bone pain, bowing of legs, deafness, facial paralysis and spinal deformities. (medwonders.com)
  • Acute onset of pain, exacerbation of symptoms with activity, and radicular radiation of pain suggest a mechanical or degenerative process such as disc disease. (medscape.com)
  • Select fellows are given the opportunity to present their research at Osteo Fellows and at the Santa Fe Bone Symposium. (endocrine.org)
  • Microscopic examination of the bone tissue reveals the deficient mineralization of the organic matrix. (britannica.com)
  • We have now developed a novel in silico experimental platform, V-Bone, to integratively explore bone remodeling by linking complex microscopic molecular/cellular interactions to macroscopic tissue/organ adaptations. (sciencemag.org)
  • The swelling of the limbs may cause the animal to look well muscled in appearance but this is in fact due to the laying down of fibrous tissue in an attempt to increase the thickness in order to maintain strength of the poorly mineralised bones. (paw-talk.net)
  • The tissue pathological features of metabolic bone disease. (scielo.org.za)
  • The bones in our bodies are living tissue. (rochester.edu)
  • Introduction Bone is a living tissue, which makes up the body skeleton and is one of the hardest structures of the animal body. (ogmaexpo.com)
  • FDA today published a final rule establishing donor eligibility criteria for donors of human cells, tissues, and cellular and tissue-based products (HCT/Ps) to help prevent the transmission of communicable disease when these products are transplanted. (news-medical.net)
  • The polmer material is designed to break down as the bone regrows leaving only natural tissue. (news-medical.net)
  • It can also occur when the bone tissue in the neck of the femur is softer than normal, causing it to bend under the weight of the body. (wikipedia.org)
  • It is a captive induced illness (not observed in the wild), and the term is used to describe a progressive non-infectious disease of the bone which covers a wide range of bone disorders. (paw-talk.net)
  • Metabolic bone diseases are caused by congenital defects of bone cells, or by factors (hormonal or tumoral) that alter bone cell function. (wustl.edu)
  • This manuscript presents histomorphometry as a quantifiable method for the accurate assessment of metabolic bone disease at cellular level. (scielo.org.za)
  • Children with metabolic bones disorders should be managed in the context of a multidisciplinary team familiar with the assessment, natural history, treatment, and follow-up of these conditions ( 26 ). (ispn.guide)
  • Why bad health leads to Kidney Disease? (selfgrowth.com)
  • 8 In 2002, the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative published practice guidelines to help primary care physicians identify patients with early CKD and improve health outcomes. (aafp.org)
  • Early postmenopausal women with osteoporosis who participate in an intense exercise program may experience reduced bone loss, reduced back pain, and lower cholesterol levels, according to an article in the May 24 issue of The Archives of Internal Medicine, one of the JAMA/Archives journals. (news-medical.net)
  • as well as the role of alkaline phosphatase in metabolic bone disorders. (ogmaexpo.com)
  • Although enzyme replacement therapy may have systemic benefits for the patient, little evidence suggests that it favorably alters the natural history of the spinal disease. (ispn.guide)
  • The spinal disease is rarely persistently active. (medscape.com)

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