Bone Diseases: Diseases of BONES.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Bone Diseases, MetabolicBone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Bone Resorption: Bone loss due to osteoclastic activity.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Renal Osteodystrophy: Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Osteomalacia: Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.Diphosphonates: Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Osteolysis: Dissolution of bone that particularly involves the removal or loss of calcium.Osteoclasts: A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.Bone Development: The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Osteitis Fibrosa Cystica: A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM.Osteoblasts: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.Parathyroid Hormone: A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.Alkaline Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.Fractures, Bone: Breaks in bones.Bone Matrix: Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.Osteitis Deformans: A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.Osteolysis, Essential: Syndromes of bone destruction where the cause is not obvious such as neoplasia, infection, or trauma. The destruction follows various patterns: massive (Gorham disease), multicentric (HAJDU-CHENEY SYNDROME), or carpal/tarsal.Osteogenesis: The process of bone formation. Histogenesis of bone including ossification.Aluminum: A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.RANK Ligand: A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.Bone Regeneration: Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.Ilium: The largest of three bones that make up each half of the pelvic girdle.Bone Density Conservation Agents: Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.Hyperparathyroidism: A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.Osteoprotegerin: A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.Dihydrotachysterol: A VITAMIN D that can be regarded as a reduction product of vitamin D2.Hyperparathyroidism, Secondary: Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Fractures, Spontaneous: Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)Bone Transplantation: The grafting of bone from a donor site to a recipient site.Osteocalcin: Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.Osteocytes: Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.Bone Diseases, Endocrine: Diseases of the bones related to hyperfunction or hypofunction of the endocrine glands.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Rickets: Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.Bone Morphogenetic Proteins: Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.Bone Substitutes: Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.Hypercalcemia: Abnormally high level of calcium in the blood.Strontium Isotopes: Stable strontium atoms that have the same atomic number as the element strontium, but differ in the atomic weight. Sr-84, 86, 87, and 88 are the stable strontium isotopes.Femur: The longest and largest bone of the skeleton, it is situated between the hip and the knee.Osteonecrosis: Death of a bone or part of a bone, either atraumatic or posttraumatic.Technetium Tc 99m Medronate: A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.Clodronic Acid: A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.Fibrous Dysplasia of Bone: A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).Osteopetrosis: Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).Calcification, Physiologic: Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.Receptor Activator of Nuclear Factor-kappa B: A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.Tibia: The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.Absorptiometry, Photon: A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.Renal Dialysis: Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.Calcium Metabolism Disorders: Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.Bone Morphogenetic Protein 2: A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.Minerals: Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.Pelvic Bones: Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.Potassium Citrate: A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher.Osteosclerosis: An abnormal hardening or increased density of bone tissue.Temporal Bone: Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).Hydroxycholecalciferols: Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.Vitamin D: A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.Jaw DiseasesCollagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.X-Ray Microtomography: X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.Skull: The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.Parietal Bone: One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.Bone Diseases, Infectious: Bone diseases caused by pathogenic microorganisms.Osteogenesis Imperfecta: COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.Technetium Compounds: Inorganic compounds that contain TECHNETIUM as an integral part of the molecule. Technetium 99m (m=metastable) is an isotope of technetium that has a half-life of about 6 hours. Technetium 99, which has a half-life of 210,000 years, is a decay product of technetium 99m.Alendronate: A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.Calcium Carbonate: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.Alveolar Bone Loss: Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.Bone Cements: Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Ergocalciferols: Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.Osteoporosis, Postmenopausal: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.Trapidil: A coronary vasodilator agent.Haversian System: A circular structural unit of bone tissue. It consists of a central hole, the Haversian canal through which blood vessels run, surrounded by concentric rings, called lamellae.Bone Cysts: Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.Hypophosphatemia: A condition of an abnormally low level of PHOSPHATES in the blood.Phosphates: Inorganic salts of phosphoric acid.Parathyroid Glands: Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.Mice, Inbred C57BLCalcitriol: The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.Imidazoles: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).N-substituted Glycines: AMINO ACIDS composed of GLYCINE substituted at the nitrogen rather than the usual carbon position, resulting in the loss of HYDROGEN BONDING donors. Polymers of these compounds are called PEPTOIDS.Medullary Sponge Kidney: A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.Nephrolithiasis: Formation of stones in the KIDNEY.Hypocalcemia: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)Mesenchymal Stromal Cells: Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Monoclonal Gammopathy of Undetermined Significance: Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia.Spine: The spinal or vertebral column.Femoral NeoplasmsParathyroidectomy: Excision of one or more of the parathyroid glands.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Frontal Bone: The bone that forms the frontal aspect of the skull. Its flat part forms the forehead, articulating inferiorly with the NASAL BONE and the CHEEK BONE on each side of the face.Core Binding Factor Alpha 1 Subunit: A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.OsteomyelitisAcid Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.Bone Morphogenetic Protein 7: A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Bone Marrow DiseasesCalcium, Dietary: Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.Radionuclide Imaging: The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.Lumbar Vertebrae: VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.Hyperphosphatemia: A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.Phosphorus Metabolism Disorders: Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.PHEX Phosphate Regulating Neutral Endopeptidase: A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.Cellular Microenvironment: Local surroundings with which cells interact by processing various chemical and physical signals, and by contributing their own effects to this environment.Cathepsin K: A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.Calcinosis: Pathologic deposition of calcium salts in tissues.Receptors, Tumor Necrosis Factor: Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.Hyperparathyroidism, Primary: A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.Maxillary DiseasesLeg Bones: The bones of the free part of the lower extremity in humans and of any of the four extremities in animals. It includes the FEMUR; PATELLA; TIBIA; and FIBULA.Acidosis, Renal Tubular: A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.Bone Marrow Neoplasms: Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.Bone Marrow Examination: Removal of bone marrow and evaluation of its histologic picture.Femoral Fractures: Fractures of the femur.Metacarpal Bones: The five cylindrical bones of the METACARPUS, articulating with the CARPAL BONES proximally and the PHALANGES OF FINGERS distally.Boronic Acids: Inorganic or organic compounds that contain the basic structure RB(OH)2.Vitamin D Deficiency: A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Hypophosphatasia: A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)Bone Morphogenetic Protein 4: A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.Breast Neoplasms: Tumors or cancer of the human BREAST.Metatarsal Bones: The five long bones of the METATARSUS, articulating with the TARSAL BONES proximally and the PHALANGES OF TOES distally.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Tarsal Bones: The seven bones which form the tarsus - namely, CALCANEUS; TALUS; cuboid, navicular, and the internal, middle, and external cuneiforms.Receptors, Cytoplasmic and Nuclear: Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.Receptors, CCR1: CCR receptors with specificity for a broad variety of CC CHEMOKINES. They are expressed at high levels in MONOCYTES; tissue MACROPHAGES; NEUTROPHILS; and EOSINOPHILS.Parathyroid Hormone-Related Protein: A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.Dihydroxycholecalciferols: Cholecalciferols substituted with two hydroxy groups in any position.Technetium: The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Bone Demineralization Technique: Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.Foot Bones: The TARSAL BONES; METATARSAL BONES; and PHALANGES OF TOES. The tarsal bones consists of seven bones: CALCANEUS; TALUS; cuboid; navicular; internal; middle; and external cuneiform bones. The five metatarsal bones are numbered one through five, running medial to lateral. There are 14 phalanges in each foot, the great toe has two while the other toes have three each.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Spinal DiseasesLow Density Lipoprotein Receptor-Related Protein-5: LDL-receptor related protein that combines with FRIZZLED RECEPTORS at the cell surface to form receptors that bind WNT PROTEINS. The protein plays an important role in the WNT SIGNALING PATHWAY in OSTEOBLASTS and during EMBRYONIC DEVELOPMENT.PyrazinesHypophosphatemia, Familial: An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Mice, SCID: Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.Radius: The outer shorter of the two bones of the FOREARM, lying parallel to the ULNA and partially revolving around it.Orthopedics: A surgical specialty which utilizes medical, surgical, and physical methods to treat and correct deformities, diseases, and injuries to the skeletal system, its articulations, and associated structures.Procollagen: A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.Bone Cysts, Aneurysmal: Fibrous blood-filled cyst in the bone. Although benign it can be destructive causing deformity and fractures.Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Ovariectomy: The surgical removal of one or both ovaries.Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.Bone Morphogenetic Protein 6: A bone morphogenetic protein that is a potent inducer of BONE formation. It plays additional roles in regulating CELL DIFFERENTIATION of non-osteoblastic cell types and epithelial-mesenchymal interactions.Calcifediol: The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Chondrocalcinosis: Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Bone Plates: Implantable fracture fixation devices attached to bone fragments with screws to bridge the fracture gap and shield the fracture site from stress as bone heals. (UMDNS, 1999)Osseointegration: The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).Periosteum: Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.Macrophage Colony-Stimulating Factor: A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).

22-oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure. (1/779)

BACKGROUND: Calcitriol therapy suppresses serum levels of parathyroid hormone (PTH) in patients with renal failure but has several drawbacks, including hypercalcemia and/or marked suppression of bone turnover, which may lead to adynamic bone disease. A new vitamin D analogue, 22-oxacalcitriol (OCT), has been shown to have promising characteristics. This study was undertaken to determine the effects of OCT on serum PTH levels and bone turnover in states of normal or impaired renal function. METHODS: Sixty dogs were either nephrectomized (Nx, N = 38) or sham-operated (Sham, N = 22). The animals received supplemental phosphate to enhance PTH secretion. Fourteen weeks after the start of phosphate supplementation, half of the Nx and Sham dogs received doses of OCT (three times per week); the other half were given vehicle for 60 weeks. Thereafter, the treatment modalities for a subset of animals were crossed over for an additional eight months. Biochemical and hormonal indices of calcium and bone metabolism were measured throughout the study, and bone biopsies were done at baseline, 60 weeks after OCT or vehicle treatment, and at the end of the crossover period. RESULTS: In Nx dogs, OCT significantly decreased serum PTH levels soon after the induction of renal insufficiency. In long-standing secondary hyperparathyroidism, OCT (0.03 microg/kg) stabilized serum PTH levels during the first months. Serum PTH levels rose thereafter, but the rise was less pronounced compared with baseline than the rise seen in Nx control. These effects were accompanied by episodes of hypercalcemia and hyperphosphatemia. In animals with normal renal function, OCT induced a transient decrease in serum PTH levels at a dose of 0.1 microg/kg, which was not sustained with lowering of the doses. In Nx dogs, OCT reversed abnormal bone formation, such as woven osteoid and fibrosis, but did not significantly alter the level of bone turnover. In addition, OCT improved mineralization lag time, (that is, the rate at which osteoid mineralizes) in both Nx and Sham dogs. CONCLUSIONS: These results indicate that even though OCT does not completely prevent the occurrence of hypercalcemia in experimental dogs with renal insufficiency, it may be of use in the management of secondary hyperparathyroidism because it does not induce low bone turnover and, therefore, does not increase the risk of adynamic bone disease.  (+info)

Osteopenia in the patient with cancer. (2/779)

Osteopenia is defined as a reduction in bone mass. It is commonly known to occur in elderly people or women who are postmenopausal due to hormonal imbalances. This condition, however, can result because of many other factors, such as poor nutrition, prolonged pharmacological intervention, disease, and decreased mobility. Because patients with cancer experience many of these factors, they are often predisposed to osteopenia. Currently, patients with cancer are living longer and leading more fulfilling lives after treatment. Therefore, it is imperative that therapists who are responsible for these patients understand the risk factors for osteopenia and their relevance to a patient with cancer.  (+info)

A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. (3/779)

The molecular mechanisms controlling bone extracellular matrix (ECM) deposition by differentiated osteoblasts in postnatal life, called hereafter bone formation, are unknown. This contrasts with the growing knowledge about the genetic control of osteoblast differentiation during embryonic development. Cbfa1, a transcriptional activator of osteoblast differentiation during embryonic development, is also expressed in differentiated osteoblasts postnatally. The perinatal lethality occurring in Cbfa1-deficient mice has prevented so far the study of its function after birth. To determine if Cbfa1 plays a role during bone formation we generated transgenic mice overexpressing Cbfa1 DNA-binding domain (DeltaCbfa1) in differentiated osteoblasts only postnatally. DeltaCbfa1 has a higher affinity for DNA than Cbfa1 itself, has no transcriptional activity on its own, and can act in a dominant-negative manner in DNA cotransfection assays. DeltaCbfa1-expressing mice have a normal skeleton at birth but develop an osteopenic phenotype thereafter. Dynamic histomorphometric studies show that this phenotype is caused by a major decrease in the bone formation rate in the face of a normal number of osteoblasts thus indicating that once osteoblasts are differentiated Cbfa1 regulates their function. Molecular analyses reveal that the expression of the genes expressed in osteoblasts and encoding bone ECM proteins is nearly abolished in transgenic mice, and ex vivo assays demonstrated that DeltaCbfa1-expressing osteoblasts were less active than wild-type osteoblasts. We also show that Cbfa1 regulates positively the activity of its own promoter, which has the highest affinity Cbfa1-binding sites characterized. This study demonstrates that beyond its differentiation function Cbfa1 is the first transcriptional activator of bone formation identified to date and illustrates that developmentally important genes control physiological processes postnatally.  (+info)

Glucocorticoid-induced secondary osteopenia in female rats: a time course study as compared with ovariectomy-induced osteopenia and response to salmon calcitonin. (4/779)

Previously we reported that 8-week treatment with methylprednisolone acetate (MPA: 0.1 mg/kg, s.c., 3 days a week) of male rats caused a novel type of osteopenia whose development was prevented by salmon calcitonin (SCT) in a dose-dependent manner. In this study, to compare the MPA-inducible osteopenia with the ovariectomy (OVX)-inducible one, female rats were used instead of male rats and a time-course study of development was made. MPA treatments for 1, 2, 4 and 8 weeks histologically induced characteristic osteopenic changes in a time-dependent manner that were histomorphometrically detectable in tibiae within 4 weeks as reduced bone mass, accelerated bone resorption, and suppressed bone formation and mineralization. Node-strut analysis revealed that the connectivity of the trabecular structure remained unaffected. Such MPA-induced changes in the trabecular structure, to be defined as thinned-but-uncut, is in a good contrast with OVX-induced unthinned-but-cut structure, although the latter osteopenic changes became detectable 2 weeks earlier. Another previous finding confirmed herein was that MPA-induced osteopenia in female rats was also completely masked by SCT (10 U/kg, s.c., 5 days a week). The results indicate that the MPA-inducible secondary osteopenic model in either sex of rats would be usable for testing anti-osteopenic drugs.  (+info)

Bone loss in long-term renal transplantation: histopathology and densitometry analysis. (5/779)

BACKGROUND: There is little information of the spectrum and factors implicated in the bone loss in long-term renal transplantation, and virtually no data using both histomorphometric and densitometric analysis. METHODS: Twenty-three males and 22 females (13 postmenopausal) were studied with a bone biopsy and densitometry. Sixteen patients were on cyclosporine A monotherapy, 20 on azathioprine + prednisolone, and 9 on cyclosporine A + prednisolone or triple therapy. The mean time after transplantation was 127 +/- 70 months. RESULTS: No group had a significant decrease in bone mineral density (BMD) of the axial skeleton compared with an age- and sex-matched normal population. Compared with sex-matched young controls, osteopenia was observed in all groups at the femoral neck (except premenopausal women and triple therapy) and in the triple-therapy group at the L1-L4 spine region. At the distal radius, osteopenia was found in all the groups. Histopathological diagnosis was mixed uremic osteodystrophy in 46.5%, adynamic bone in 23.2%, hyperparathyroid disease in 13.9%, and normal bone in 16.3%. The diagnosis was not different according to immunosuppressive therapy, but men tended to show more mixed uremic bone disease. There was no significant difference in BMD between histopathological subtypes. In general, patients showed slight osteoclast function increase, osteoblast function decrease, and marked retardation of dynamic parameters. The cyclosporine A monotherapy group had a significantly lower appositional rate than azathioprine + prednisolone. Men had a significantly lower bone volume than women, and premenopausal women had a significantly lower mineralizing surface than postmenopausal women and men. In the multivariate analysis, male gender, time after transplantation, old age, and time on dialysis prior to transplantation were significant predictive factors for a negative effect on bone mass. CONCLUSIONS: Long-term renal transplant-patients showed reduced BMD in both trabecular and cortical bone. This reduction in BMD was not as severe as in short-term reports and was associated with osteoclast stimulation, osteoblast suppression, and retardation of mineral apposition and bone formation rates. Bone mass loss was not different between the immunosuppression therapy groups. Male gender and age were the strongest predictive factors for low bone mass.  (+info)

Reduced bone density at completion of chemotherapy for a malignancy. (6/779)

OBJECTIVES: Osteoporosis and pathological fractures occur occasionally in children with malignancies. This study was performed to determine the degree of osteopenia in children with a malignancy at completion of chemotherapy. METHODS: Lumbar spine (L2-L4) bone mineral density (BMD; g/cm2) and femoral neck BMD were measured by dual energy x ray absorptiometry in 22 children with acute lymphoblastic leukaemia (ALL), and in 26 children with other malignancies. Apparent volumetric density was calculated to minimise the effect of bone size on BMD. Results were compared with those of 113 healthy controls and expressed as age and sex standardised mean Z scores. RESULTS: Patients with ALL had significantly reduced lumbar volumetric (-0.77) and femoral areal and volumetric BMDs (-1.02 and -0.98, respectively). In patients with other malignancies, femoral areal and apparent volumetric BMDs were significantly decreased (-0.70 and -0.78, respectively). CONCLUSIONS: The results demonstrate that children with a malignancy are at risk of developing osteopenia. A follow up of BMD after the completion of chemotherapy should facilitate the identification of patients who might be left with impaired development of peak bone mass, and who require specific interventions to prevent any further decrease in their skeletal mass and to preserve their BMD.  (+info)

Is low plasma 25-(OH)vitamin D a major risk factor for hyperparathyroidism and Looser's zones independent of calcitriol? (7/779)

BACKGROUND: Recent reports suggest that calcitriol might not be the sole active metabolite of vitamin D and that plasma concentrations of 25-(OH)vitamin D (25OHD) are often abnormally low in hemodialysis patients. We have therefore evaluated plasma 25OHD as a risk factor for parathyroid hormone (PTH) hypersecretion and radiological bone disease. We carried out a cross-sectional study during the month of September in an Algerian dialysis center of 113 patients who were not taking supplements of alphacalcidol or calcitriol. METHODS: Plasma 25OHD, calcitriol, PTH, calcium, phosphate, bicarbonate, and aluminum were measured, and x-rays of the hands and pelvis were obtained for evaluation of subperiosteal resorption and Looser's zones. RESULTS: The median plasma 25OHD was 47.5 nmol/liter (range 2.5 to 170.0). Univariate analysis showed that plasma PTH was correlated positively with months on maintenance dialysis and negatively with plasma 25OHD, calcitriol, calcium, bicarbonate and aluminum, but not with that of phosphate. plasma 25OHD was positively correlated with calcium and calcitriol. Using multiple regression analysis, only plasma 25OHD (negative) and the duration on maintenance dialysis (positive) were independently linked to plasma PTH. The prevalence of isolated subperiosteal resorption (ISR) was 34%, and that of the combination of resorption with Looser's zones (CRLZ) was 9%; thus, only 57% of the patients had a normal x-ray appearance. These groups were comparable with regards to age, gender, and duration on dialysis. When the biochemical measurements of the patients with CRLZ were compared with those from patients without radiological lesions, plasma 25OHD was the only parameter to show a statistically significant difference, being significantly lower in the CRLZ group (26 +/- 18 vs. 57 nmol/liter, ANOVA, P < 0.004). Plasma 25OHD was also significantly lower in the ISR group (44, P < 0.05) than in the normal x-ray group, and plasma Ca (P < 0.003) and bicarbonate (P < 0.02) were lower. Logistical analysis showed that the presence of resorption was independently linked only with plasma PTH. Looser's zones and subperiosteal resorption were not seen in patients with plasma 25OHD of more than 40 (Looser's zones) and more than 100 nmol/liter (subperiosteal resorption). The optimal range for intact PTH in hemodialysis patients with mild aluminum overload is 10 to 25 pmol/liter. We found that plasma PTH was inappropriately high only when plasma 25OHD was less than 100 nmol/liter. With a plasma 25OHD of between 100 and 170 nmol/liter, hypercalcemia was present with a plasma PTH of less than 10 pmol/liter in only one case. CONCLUSIONS: This cross sectional study shows that low plasma 25OHD is a major risk factor for hyperparathyroidism and Looser's zones. In dialysis patients, we suggest that the plasma levels of 25OHD are maintained around the upper limit of the reference range of sunny countries.  (+info)

Effects of XT-44, a phosphodiesterase 4 inhibitor, in osteoblastgenesis and osteoclastgenesis in culture and its therapeutic effects in rat osteopenia models. (8/779)

We have reported that denbufylline, a phosphodiesterase 4 (PDE4) inhibitor, inhibits bone loss in Walker256/S tumor-bearing rats, suggesting therapeutic potentiality of a PDE4 inhibitor in osteopenia. In the present study, effects of a new PDE4 inhibitor, 1-n-butyl-3-n-propylxanthine (XT-44), in bone were evaluated in cell cultures and animal experiments. In rat bone marrow culture, XT-44 stimulated mineralized-nodule formation, whereas it inhibited osteoclast-like cell formation in mouse bone marrow culture. In Walker256/S-bearing rats (6-week-old female Wistar Imamichi rats), rapid decrease in bone mineral density (BMD) was prominent, and oral administration of XT-44 (0.3 mg/kg, every 2 days) inhibited the decrease in BMD. In the second animal experiment, female Wistar rats (6-week-old) were sciatic neurectomized, and XT-44 was orally administered to these rats every 2 days for 4 weeks. XT-44 administration (0.3 mg/kg) recovered BMD in these neurectomized animals. Furthermore, 19-week-old, female Wistar rats were ovariectomized (OVX), and 15 weeks after surgery, these rats were orally administered XT-44 every 2 days for 8 weeks. XT-44 treatment (1 mg/kg) increased the BMD of OVX rats. These results indicate that XT-44 could be a candidate as a therapeutic drug for treating osteopenia including osteoporosis.  (+info)

*Coxa vara

Other common causes include metabolic bone diseases (e.g. Paget's disease of bone), post-Perthes deformity, osteomyelitis, and ... Coxa vara is also seen in Niemann-Pick disease. Congenital coxa vara[edit]. Presence at birth is extremely rare and associated ... It can also occur when the bone tissue in the neck of the femur is softer than normal, causing it to bend under the weight of ... This may either be congenital or the result of a bone disorder. The most common cause of coxa vara is either congenital or ...

*Scintigraphy

Rosen CJ (2008-11-18). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. John Wiley and Sons. pp. 168 ... Bone[edit]. Main article: Bone scintigraphy. For example, the ligand methylene-diphosphonate (MDP) can be preferentially taken ... September 2007). "Bone metastases of differentiated thyroid cancer: impact of early 131I-based detection on outcome". Endocrine ... By chemically attaching technetium-99m to MDP, radioactivity can be transported and attached to bone via the hydroxyapatite for ...

*Scintigraphy

Rosen, Clifford J. (2008-11-18). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. John Wiley and Sons ... Bone[edit]. Main article: Bone scintigraphy. For example, the ligand methylene-diphosphonate (MDP) can be preferentially taken ... By chemically attaching technetium-99m to MDP, radioactivity can be transported and attached to bone via the hydroxyapatite for ... Redistribution indicates the existence of coronary steal and the presence of ischemic coronary artery disease.[4] ...

*Heterotopic ossification

Metabolic Bone and Stone Disease. BEC Nordin, AG NEED, HA Morris: Churchill Livingstone, 1993. p 328-9 Principles and Practice ... The three-phase bone scan may be the most sensitive method of detecting early heterotopic bone formation. However, an ... About every third patient who has total hip arthroplasty (joint replacement) or a severe fracture of the long bones of the ... The only definitive diagnostic test in the early acute stage is a bone scan, which will show hetertopic ossification 7 - 10 ...

*Marrow adipose tissue

Metabolic Bone Disease and Related Research. 4 (1): 69-75. doi:10.1016/0221-8747(82)90011-X. Rubin, M. R.; Manavalan, J. S.; ... "Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise". Bone. 64: 39-46. doi:10.1016/j.bone. ... reduced bone mineral density, and an altered osteoblast differentiation program". Bone. 35 (5): 1046-1058. doi:10.1016/j.bone. ... high-fat diets induces low bone mineral density and reduces bone formation in rats". Journal of Bone and Mineral Research. 25 ( ...

*Green iguana in captivity

... the iguana develops Metabolic Bone Disease (MBD). Metabolic Bone Disease causes soft bones, stunted growth, permanent bone ... and subsequently will develop metabolic bone disease which is fatal if not treated. In some locales, iguanas are considered ... "Identification and treatment of metabolic bone disease". Melissa Kaplan's Herp Care Collection. anapsid.org. Retrieved 2007-06- ... deformities, frequent broken bones, loss of limbs and ultimately, death. Although they will consume a wide variety of foods if ...

*Radiographic classification of osteoarthritis

Page 117 in Barbara N. W. Weissman (2009). Imaging of Arthritis and Metabolic Bone Disease. Elsevier Health Sciences. ISBN ... The distances between the bones in the ankle are normally as follows: Talus - medial malleolus : 1.70 ± 0.13 mm Talus - tibial ... "Osteoarthritis Classification Scales: Interobserver Reliability and Arthroscopic Correlation". The Journal of Bone and Joint ... but most of the span of the Ahlbäck system focused at various degrees of bone defect or loss, and it is therefore less useful ...

*Polyuria

Imaging of arthritis and metabolic bone disease. Philadelphia, PA: Mosby/Elsevier. p. 679. ISBN 978-0-323-04177-5. Retrieved 5 ... Polyuria is usually viewed as a symptom or sign of another disorder (not a disease by itself), but it can be classed as a ... Mariani, Laura (2007). "The Renal Manifestations of Thyroid Disease". Journal of the American society of Nephrology: 22-26. ... hyperthyroidism hypopituitarism Conn's disease hyperglycaemia Circulation congestive heart failure Cardiorespiratory disease ...

*Pogona

... metabolic bone disease, atadenovirus, and paralysis. Metabolic bone disease (MBD) is a common disease that can be fatal for ... Hypocalcemia is most often tied to metabolic bone disease. Low levels of calcium can result in twitching muscles, or seizures. ... Bearded dragons require UVB to help enable D3 synthesis and to prevent metabolic bone disease. Bearded dragons also require UVA ... Maintaining a diet which consists of enough calcium is crucial to avoiding hypocalcemia as well as metabolic bone disease. ...

*Teijin

Pharmaceuticals in the treatment of bone and joint disease, respiratory disease and cardiovascular and metabolic disease ...

*Cortisol

... reduces bone formation, favoring long-term development of osteoporosis (progressive bone disease). It transports ... National Endocrine and Metabolic Diseases Information Service (NEMDIS). July 2008. Retrieved 16 March 2015. These benign, or ... Addison's disease, Nelson's syndrome) Secondary hypercortisolism (pituitary tumor resulting in Cushing's disease, pseudo- ... It also decreases bone formation. In the early fasting state, cortisol stimulates gluconeogenesis (the formation of glucose), ...

*Ben Garrod

Metabolic Bone Disease in Historical Captive Primates". Int J Primatol. 36 (2): 398-411. doi:10.1007/s10764-015-9831-7. ( ... Alice Roberts Adam Rutherford Jane Goodall David Attenborough Nikki Gordon-Bloomfield "BBC Four - Secrets of Bones". Bbc.co.uk ... in addition to his own six-part series called Secrets of Bones on BBC Four. He has also presented numerous short films on the ...

*Sestamibi parathyroid scintigraphy

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. John Wiley and Sons. pp. 168-. ISBN 978-0-9778882-1- ... In patients with multiglandular parathyroid disease, imaging is not as reliable. In addition, size limitation of the abnormal ...

*Richard Eastell

Academic Unit of Bone Metabolism Eastell, Richard (1984). "Investigation of metabolic bone disease by in vivo neutron ... Academic Unit of Bone Metabolism Metabolic Bone Centre The Mellanby Centre at the University of Sheffield Collection of links ... 2003), "Relationship of Early Changes in Bone Resorption to the Reduction in Fracture Risk With Risedronate", Journal of Bone ... Other bone medicine academics, speaking on BBC Radio 4's programme "You and Yours", took the view that the paper in question ...

*Norethisterone

... a major risk-factor for veno-occlusive disease in the liver after allogeneic bone marrow transplantation". Blood. 92 (12): 4568 ... Jeffrey K. Aronson (21 February 2009). Meyler's Side Effects of Endocrine and Metabolic Drugs. Elsevier. pp. 217, 253, 275. ... Wiegratz, Inka; Kuhl, Herbert (2006). "Metabolic and clinical effects of progestogens". The European Journal of Contraception ... The enzymes involved in these metabolic processes are 5α- and 5β-reductase as well as 3α- and 3β-hydroxysteroid dehydrogenase ( ...

*Hip fracture

Homocysteine, a toxic 'natural' amino acid linked to the cause of heart disease. Other metabolic bone diseases such as Paget's ... Stress fractures may occur in the hip region with metabolic bone disease. Benign or malignant primary bone tumors are rare ... While osteoarthritis and osteoporosis are associated with bone fracture as we age, these diseases are not the cause of the ... which is a degenerative disease due to age and decrease in bone mass. The average age for suffering a hip fracture is 77 years ...

*Gamma-glutamyltransferase

Betro MG, Oon RC, Edwards JB (November 1973). "Gamma-glutamyl transpeptidase in diseases of the liver and bone". American ... Yokoyama H (June 2007). "[Gamma glutamyl transpeptidase (gammaGTP) in the era of metabolic syndrome]". Nihon Arukōru Yakubutsu ... ALP can also be increased in certain bone diseases, but GGT is not. More recently, slightly elevated serum GGT has also been ... In general, ALP is still the first test for biliary disease. The main value of GGT over ALP is in verifying that ALP elevations ...

*Blue tegu

... a calcium deficiency can lead to metabolic bone disease, which can be fatal. Blue tegus are similar in size and body structure ...

*Doxercalciferol

... (trade name Hectorol) is drug for secondary hyperparathyroidism and metabolic bone disease. It is a synthetic ...

*Abbott's crested lizard

The metabolic bone disease is a product of lack of UVB light and calcium. Natural light gives off vitamin D3. This vitamin is ... 14, 52-53). Addition issues that can occur in tame dragons are vitamin A deficiency and metabolic bone disease. Vitamin A ... The disease can cause soft bones and muscle cramping (Langerwerf, 2006, p. 54-55). According to Langerwerf, signs of an ...

*Crested gecko

Eggs laid by a female whose calcium reserves are low occasionally exhibit signs of congenital metabolic bone disease, such as ... An unbalanced diet containing insufficient calcium can quickly lead to metabolic bone disease (MBD). Though the export of wild ...

*Etelcalcetide

"Evidence for Chronic Kidney Disease-Mineral and Bone Disorder Associated With Metabolic Pathway Changes". Medicine. 94 (32): ... Due to the lower iPTH levels achieved by the use of this drug, it is possible that adynamic bone disease could occur at levels ... Etelcalcetide is used for the treatment of secondary hyperparathyroidism in people with chronic kidney disease (CKD) on ...

*Stuart Sprague

He has high interest in kidney stones, post transplant bone disease and, metabolic bone disease. "Stuart M. Sprague, DO". ... is a chief of the Division of Nephrology and Hypertension and a founder of Chronic Kidney Disease Clinic. In 1995 he joined ... NorthShore University HealthSystem and before that was a director of both the University of Chicago's Renal Bone Program and ...

*Distal radius fracture

The risk of injury is increased in patients with osteoporosis and other metabolic bone diseases. In young adults, this fracture ... The ulna bone may also be broken. In younger people these fractures typically occur during sports or a motor vehicle collision ... A distal radius fracture, also known as wrist fracture, is a break of the part of the radius bone which is close to the wrist. ... Carpal bone fractures such as those to the scaphoid have been described, whereas instability or dislocations of the wrist are ...

*Nile monitor

UVB lighting is required to prevent metabolic bone disease, a common ailment in captive lizards. The humidity should be ...

*Rickets

... an overlooked contribution to metabolic bone disease". International Journal of Epidemiology. 32 (3): 340-1. doi:10.1093/ije/ ... Maternal deficiencies may be the cause of overt bone disease from before birth and impairment of bone quality after birth. The ... Occasionally surgery may be done to fix bone deformities. Genetic forms of the disease typically require specialized treatment ... Rickets is a condition that results in weak or soft bones in children. Symptoms include bowed legs, stunted growth, bone pain, ...

*Levothyroxine

Mandel SJ, Brent GA, Larsen PR (September 1993). "Levothyroxine therapy in patients with thyroid disease". Annals of Internal ... as thyroid hormones may cause an acute adrenal crisis by increasing the metabolic clearance of glucocorticoids.[20] For oral ... suppression of TSH values below normal values will frequently cause cardiac side-effects and contribute to decreases in bone ... For older people (over 50 years old) and people with known or suspected ischemic heart disease, levothyroxine therapy should ...

*International Menopause Society

"Anna Fenton endocrinologist specialty in women's health, polycystic ovarian syndrome, menopause, PMS and metabolic bone disease ...
TY - JOUR. T1 - Effects of increasing doses of 1α-hydroxyvitamin D2 on calcium homeostasis in postmenopausal osteopenic women. AU - Gallagher, John Christopher G.. AU - Bishop, Charles W.. AU - Knutson, Joyce C.. AU - Mazess, Richard B.. AU - Deluca, Hector F.. PY - 1994/5. Y1 - 1994/5. N2 - This study is the first reported administration of 1α-hydroxyvitamin D2 (1α-OHD2) to human subjects. A total of 15 postmenopausal osteopenic women were given increasing oral doses of 1α-OHD2, beginning with a low dose of 0.5 μg/day. In 15 subjects, the doses were raised at weekly intervals to 1.0, 2.0, 4.0, and 5.0 μg/day, and in 5 of these subjects, the dose was further increased to 8.0 or 10.0 μg/day. Mean urine calcium ± SEM showed a dose-related increase from 134 ± 17 mg/24 h on 0.5 μg/day to 198 ± 21 mg/24 h on 4.0 μg/day (p ,0.05) and to 241 ± 35 mg/24 h on 5.0 μg/day (p ,0.05). No subjects had hypercalciuria (, 350 mg/24 h, the upper limit of the laboratory normal range) at doses less ...
Bone disease - Metabolic bone disease: The normal function of bone requires an adequate supply of amino acids (the building blocks for proteins) for the synthesis of collagen, the chief component of the organic matrix; of calcium and phosphate for mineralization of the organic matrix; and of other organic compounds and mineral elements. Also, growth, repair, and remodeling of the bone tissue require a precisely regulated supply of hormones, vitamins, and enzymes. Skeletal disease, when it is due to inadequacies in the supply or action of the above essentials, associated with abnormalities outside the skeleton, is termed metabolic; in such cases the entire skeleton is affected.
ASBMR (2008) Chapter 42. Genetics of Osteoporosis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470623992.ch42 ...
The Metabolic Bone Diseases Clinic at Tufts Medical Center in Boston provides care to manage increased risk for fragility fractures due to bone diseases, like osteoporosis.
This clinic treats patients who have metabolic bone diseases - thin bones, thick bones, soft bones, brittle bones and irregular bones. These diseases are caused by problems with mineral metabolism, nutrition, and some genetic diseases. In addition to the above list, we see patients with many kinds of diseases, including:
In recent years there has been an increase in the diagnosis of Metabolic Bone disease in hedgehogs and it is a life-threatening syndrome. While the
Metabolic bone diseases are disorders of bone strength, usually caused by abnormalities of minerals (such as calcium or phosphorus), vitamin D, bone mass or
Searching for osteopenia or are you wondering, What is osteopenia? Learn about osteopenia treatments and osteopenia symptoms from Dr. Weil.
Results Data from the first fifteen babies is presented.. Using an ALP cut-off of 400 IU/L to define osteopenia, babies with increased ALP, tended to have a higher PTH (p = 0.07), with mean PTH,7.9 pmol/L being associated with bone disease. Hypophosphatemia (Phosphate,1.5 mmol/l), a known risk factor, was significantly associated with hyperparathyroidism (p = 0.005). PTH and TmP-GFR were inversely correlated. Plasma calcium remained unchanged and within normal range. ...
Mild cases can be treated by proper diet. Dusting salad and insects with a high-quality calcium and D3 supplement is the most effective. The best one on the market right now is Rep-Cal Calcium with Vit.D. Make sure the greens you are using are nutritious and not calcium binding (refer to my list of appropriate fruits and vegetables).. Install a new mercury vapor UVB bulb. Whenever possible, expose your bearded dragon to unfiltered natural sunlight under supervision.. Severe MBD results in rubbery bones and eventually, death. If you suspect that your dragon has MBD, get him/her to the vet as soon as possible.. ...
My osteopenia has worsened since my bone scan 2 years ago. Id love to hear from others who are dealing with this. I do plan to start walking more,...
Osteopenia is an early stage of bone loss which can eventually lead to Osteoporosis. Learn the symptoms, diagnosis & treatments for Osteopenia at Apollo Hospitals.
Since weve been covering vitamin D lately, I thought wed discuss some of the metabolic bone diseases caused by D deficiency in children and adults, like osteomalacia, aka rickets in children. Accord
The values of calcium content of foods in the table are not to be taken as remotely absolute, this is one set of figures taken from Fowler, M. (1986) Metabolic bone disease in Zoo & Wild Animal Medicine 2nd edition. There are others and they all vary depending who takes them, where they come from and which lab tests, they should be regarded as indicative of trends only.. ...
Femoral neck osteopenia refers to a decrease in bone density in the top part of the femur where it connects to the hip, explains the University of Maryland. The condition can lead to weakening of the...
... is the health condition characterized by bone density being lower than normal peak density, but not low enough for osteoporosis to be used in describing it. Bone density is the measurement of how strong and dense the bones are. This is the forum for discussing anything related to this health condition
Osteopenia is the condition in which bone density is somewhat less than a standard young person of the same sex, and is best treated with natural approach.
My doctor prescribed Fosamax for osteopenia. I took the stuff for about 6 years, and each of my bone density test results were a little worse than the previous ...
Hello everyone, Im back after several years of not having a computer. Im posting in this section because Ive opted not to pursue surgery. I have developed osteopenia and my curve has been stable in the upper 40s lower 50s depending on who reads the radiographs. I couldnt keep up with posting after my computer fried. I was too cheap to buy a new one since I could do my essential tasks from my phone. My HMO hospital hired a new scoliosis surgeon whom I was not impressed with. In his
Hello! First, Id like to express my appreciation for your very informative website! I am a healthy 62 yr old woman with osteopenia and mild arthritic
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The investigators hypothesis is that secondary causes of bone loss are prevalent in patients with breast and prostate cancer, and those patients with se
Question - Having pain in hip joint. X-rays results showed some osteopenia. Recommended calcium and vitamin D. Remedy?. Ask a Doctor about diagnosis, treatment and medication for Osteopenia, Ask a General & Family Physician
Osteoporosis: Osteoporosis, disease characterized by the thinning of bones, with a consequent tendency to sustain fractures from minor stresses. Osteoporosis is the most common metabolic bone disease, and its name literally means
My expertise is in the area of skeletal tissue biology. I have studied skeletal biology for more than 30 years and have broad knowledge across many areas in the field, including metabolic bone disease and orthopedic-related diseases. I have carried out numerous preclinical assessments of pharmacological compounds as they relate to safety and efficacy in the treatment of fracture and osteoporosis. I have expertise in skeletal tissue structure and the histomorphometric assessment of skeletal tissues. I was among the first four labs in the United States to develop in vitro osteoblast cultures and helped to establish the standard time dependent sequence of osteogenic differentiation in vitro. My laboratory also was one of four to initially isolate the proteins and clone the major extracellular matrix proteins of bone. I have served on the NIH IRG for Orthopedics, NASA review panels for skeletal tissue biology and the DOD review panels for orthopedic related research.. ...
While most people experience some loss of bone mass as they age, osteopenia and osteoporosis are not inevitable parts of the aging process.
We believe that every child deserves to live an active lifestyle with hope for a bright future. Thats why we are so steadfast in treating children with brittle bone disease or osteogenesis imperfecta (OI), a genetic disorder that encourages regular fractures and a lifetime of surgeries, casts and periods of immobility. Our goal is to increase the quality of life of children with OI through compassionate care, advanced medical options and continued research aimed at a cure.
The triad of Phemister refers to three features seen classically with tuberculous arthropathy: juxta-articular osteopaenia/osteoporosis peripheral osseous erosions gradual narrowing of joint space
Maria recently posted a wonderful review article about treatments for osteopenia/osteoporosis which indicated that biophosphanates actually make bones
Kirk Hamilton interviews Dr. Leslie Shen an Associate Professor of Pathology at Texas Tech University Health Sciences Center in Lubbock, Texas. She is the co-author of a paper entitled Effect Of Green Tea and Tai Chi on Bone Health in Postmenopausal Osteopenic Women: A 6-Month Randomized Placebo-Controlled Trial, in the journal Osteoporosis International published in July of 2011. Originally from Taiwan, Dr. Shen has now spent over 2 decades studying how and why some Eastern... ...
Results Patients were mostly women (96.4%) and the mean age was 55.6 ± 10.6 years. The mean follow-up duration of RA was 8.8 ± 4.3 years. At initial visit, 9.1% of patients had a past history of steroid use for diseases other than RA. Rheumatoid factor was positive in 330 of 531 patients (62.1%) and anti-CCP antibodies in 138 of 206 patients (67%). The mean duration between the initial visit and the first BMD screening was 32.7 ± 40.2 months and the prevalence of osteoporosis was 31.7% at screening (95% confidence interval (CI) 27.6 to 36.1). Estimated transition time to osteoporosis was 72 months (95% CI 36 to 90) for patients with normal BMD, 62 months (95% CI 28 to 126) for patients with mild osteopenia, 34 months (95% CI 16 to 60) for patients with moderate osteopenia, and 17 months (95% CI 10 to 21) for patients with severe osteopenia. The adjusted odds ratio (OR) for osteoporosis at initial BMD testing was high for older age (OR 1.066, 95% CI 1.029 to 1.105, p , 0.0001), past steroid ...
ABSTRACT. The term metabolic bone disease encompasses an unrelated group of systemic conditions that impact on skeletal collagen and mineral metabolism. Their asymptomatic progression leads to advanced skeletal debilitation and late clinical manifestation. This article provides a brief overview of advances in the understanding of the pathogenesis of rickets, osteomalacia and age-related osteoporosis.. ...
2000-5000 IU/kg) 2. Prolapsed Organs 3. Metabolic Bone Disease Turtles fed primarily organ meats (liver, heart) or pure muscle (beef, pork, chicken) will develop metabolic bone disease and other nutritional problems. Rx. Vit D3 parenteral and diet correction with suppliments. 4. Shell Rot Usually secondary to the turtle spending all of its time in the water or water which is of poor quality Infectious Diseases 1. Bacterial Disease Debilitated chelonians are vulnerable to respiratory diseases caused by bacteria. Aquatic turtles with lung disease will frequently float in the water asymmetrically or have difficulty surfacing or submerging Septic cutaneous ulcerative disease (SCUD) is a problem most frequently observed in feshwater aquatic turtles like sliders and cooters. The causative agent is Citrobacter fruendii, a Gram-negative rod. Affected animals may present with deep skin ulcers in a variety of locations. Turtles are prone to both superficial and deep mycoses. There are several reports in ...
Mammalian focal adhesion proteins Pinch1 and Pinch2 regulate integrin activation and cell-extracellular matrix adhesion and migration. Here, we show that deleting Pinch1 in osteocytes and mature osteoblasts using the 10-kb mouse Dmp1-Cre and Pinch2 globally (double KO; dKO) results in severe osteopenia throughout life, while ablating either gene does not cause bone loss, suggesting a functional redundancy of both factors in bone. Pinch deletion in osteocytes and mature osteoblasts generates signals that inhibit osteoblast and bone formation. Pinch-deficient osteocytes and conditioned media from dKO bone slice cultures contain abundant sclerostin protein and potently suppress osteoblast differentiation in primary BM stromal cells (BMSC) and calvarial cultures. Pinch deletion increases adiposity in the BM cavity. Primary dKO BMSC cultures display decreased osteoblastic but enhanced adipogenic, differentiation capacity. Pinch loss decreases expression of integrin β3, integrin-linked kinase (ILK), ...
ScoliosisJournal: Is decreased bone mineral density associated with development of scoliosis? A bipedal osteopenic rat model The scientists involved in this study didnt find the what they were looking for but once again they found that Scoliosis was associated with hypokyphosis (flat back). Just about everything I have read shows that Scoliosis is associated with hypokyphosis. My son doesnt have severe flat back but his spine has very little, natural kyphosis. Its fairly straight
2016 Foja, Sabine; Hoffmann, Katrin; Auw-Haedrich, Claudia; Reinhard, Thomas; Rupprecht, Andreas; Gruenauer-Kloevekorn, Claudia (2016): Identification of two novel mutations in the cornea-specific TGFBI gene causing unique phenotypes in patients with corneal dystrophies. In: International ophthalmology 36 (6), S. 867-873. DOI: 10.1007/s10792-016-0216-5. Job, Florian; Mizumoto, Shuji; Smith, Laurie; Couser, Natario; Brazil, Ashley; Saal, Howard, Patterson, Melanie; Gibson Margaret I.; Soden, Sarah; Miller, Neil; Thiffault, Isabelle; Saunders, Carol; Yamada, Shuhei; Hoffmann, Katrin; Sugahara, Kazuyuki; Farrow, Emily (2016): Functional validation of novel compound heterozygous variants in B3GAT3 resulting in severe osteopenia and fractures: expanding the disease phenotype. In: BMC medical genetics 17 (1), S. 86. DOI: 10.1186/s12881-016-0344-9. Kouz, Karim; Lissewski, Christina; Spranger, Stephanie; Mitter, Diana; Riess, Angelika; Lopez-Gonzalez, Vanesa; Lüttgen, Sabine; Aydin, Hatip; von ...
Inclusion Criteria:. Postmenopausal at least 5 years; Screening bone mineral density more than or equal to 2.5 S.D.s below the mean for young adults at the lumbar spine or femoral neck.. Exclusion Criteria:. Metabolic bone disease other than osteoporosis; Taking approved medications for osteoporosis; Have had a recent osteoporotic fracture (within 1 year) and/or have a bone mineral density more than 4.5 S.D.s below the mean for young adults at the lumbar spine or femoral neck. ...
Medical Director, Johns Hopkins Metabolic Bone Center. Expertise, Disease and Conditions: Endocrinology, Metabolic Bone Disease, Nutrition, Osteoporosis. Research Interests: The role of nutrition and environmental factors in bone health, The role of... [more]. ...
Journal of Osteoporosis is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working on the diagnosis, prevention, treatment and management of osteoporosis and other metabolic bone diseases. The journal publishes research articles, review articles, as well as clinical studies related to the biology, physiology, and pathology of bone and muscle.
Journal of Osteoporosis is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working on the diagnosis, prevention, treatment and management of osteoporosis and other metabolic bone diseases. The journal publishes research articles, review articles, as well as clinical studies related to the biology, physiology, and pathology of bone and muscle.
Osteoporosis is a progressive metabolic bone disease, which is characterized by decrease in bone mineral density, mass, bone calcium loss from bones. This leads to reduced bone strength, increasing the fragility and an increase in the risk of fractures. The most vulnerable are the vertebrae and the femur. Breaks can occur after minor trauma or even without getting hurt, so-called spontaneous fractures can happen. This is a "mute" disease, begins insidiously, without any symptoms and is usually revealed only when there is a break of some bones. Thats why they call it the "silent thief of bones." Sometimes the first symptoms occur like a pain in the bones, joints, muscles, but we usually do not think of osteoporosis as a possible cause ...
Osteoporosis is a progressive metabolic bone disease, which is characterized by decrease in bone mineral density, mass, bone calcium loss from bones. This leads to reduced bone strength, increasing the fragility and an increase in the risk of fractures. The most vulnerable are the vertebrae and the femur. Breaks can occur after minor trauma or even without getting hurt, so-called spontaneous fractures can happen. This is a "mute" disease, begins insidiously, without any symptoms and is usually revealed only when there is a break of some bones. Thats why they call it the "silent thief of bones." Sometimes the first symptoms occur like a pain in the bones, joints, muscles, but we usually do not think of osteoporosis as a possible cause ...
We offer comprehensive care and support for those with osteoporosis or metabolic bone disease. The Dr. David Hanley Osteoporosis Centre Calgary supplies education for clients, the community and healthcare providers including information about: diagnosis, prevention, treatment, information on exercise classes, latest clinical practice guidelines and more.
Do you own a lizard, a parakeet, a sugar glider? Then you should know about metabolic bone disease (MBD) aka (nutritional secondary hyperparathyroidism) and how to prevent it. Reptiles, birds and … ...
In metabolic bone diseases, the alterations in fibrillar level bone-material quality affecting macroscopic mechanical competence are not well-understood quantitatively. Here, we quantify the fibrillar level deformation in cantilever bending in a mouse model for hereditary rickets (Hpr). Microfocus in-situ synchrotron small-angle X-ray scattering (SAXS) combined with cantilever bending was used to resolve nanoscale fibril strain in tensile- and compressive tissue regions separately, with quantitative backscattered scanning electron microscopy used to measure microscale mineralization. Tissue-level flexural moduli for Hpr mice were significantly (p|0.01) smaller compared to wild-type (~5 to 10-fold reduction). At the fibrillar level, the fibril moduli within the tensile and compressive zones were significantly (p|0.05) lower by ~3- to 5-fold in Hpr mice compared to wild-type mice. Hpr mice have a lower mineral content (24.2±2.1Cawt.% versus 27.4±3.3Ca wt.%) and its distribution was more heterogeneous
Researchers in the UC Division of Endocrinology, Diabetes & Metabolism are recognized for excellence in the fields of endocrine autoimmunity, metabolic bone disease and diabetes.
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TY - JOUR. T1 - Multifunctional p62 Effects Underlie Diverse Metabolic Diseases. AU - Long, Min. AU - Li, Xing. AU - Li, Li. AU - Dodson, Matthew. AU - Zhang, Donna. AU - Zheng, Hongting. PY - 2017. Y1 - 2017. N2 - p62, a protein capable of binding both ubiquitin and autophagy substrates, is well established as a key regulator in cancer and neurodegenerative diseases. Recently, there has been accumulating evidence that p62 is also a pivotal regulator in metabolic diseases, such as obesity, T2DM, NAFLD, metabolic bone disease, gout and thyroid disease. This review summarizes the emerging role of p62 on these diseases by considering its functional domains, phenotypes in genetically modified animals, clinically observed alterations, and its effects on downstream metabolic signaling pathways. At the same time, we highlight the need to explore the roles played by p62 in the gastrointestinal environment and immune system, and the extent to which its elevated expression may confer protection against ...
A turtle shell is made of two parts: the plastron and carapace. Both are covered with scutes. Retained scutes (dysecdysis), metabolic bone disease, and trauma are common diseases of the shell.
Osteopenia and osteoporosis are increasingly reported in HIV-infected patients, and appear to be more frequent than in general population. However, pathogenesis remains unclear, and published studies still give non concordant results.. We therefore started a prospective study, to assess the potential role of ARV in the occurrence of osteopenia and osteoporosis. BMD evolution over a 2-years period of follow-up, will be compared between patients starting ARV therapy, and subjects without HAART (no indication of treatment). A correlation between BMD and several factors will be looked at (see below).. This study with individual direct benefice, is conducted in 3 outpatients clinics (Strasbourg, Colmar, Mulhouse) in collaboration with the rheumatologic teams. 60 patients are planned to be included over a 3-years inclusion period ...
A Multicenter Open-label Extension Study to Assess the Long-term Safety and Efficacy of KAI-4169 (also known as AMG 416) in the Treatment of Chronic Kidney Disease-Mineral and Bone Disorder in Patients with Secondary ...
Serrapeptase supports treatment of Osteoporosis and Osteopenia immensely as it clears out all of the inflammation, mucus and dead tissue in the body.
Regarding scheduling, or to reach your doctors office: Phone: (410) 955-3663. To send records, labs or other documents: Fax: (410) 367-2042. Mailing address (please do not mail items to the clinic):. Division of Endocrinology, Diabetes & ...
Ortman, L.F., Hausmann, E. and Dunford, R.G. (1989) Skeletal osteopenia and residual ridge resorption. Journal of Prosthetic Dentistry, 61, 321-325. doi10.1016/0022-3913(89)90137-6
Bone mass peaks in your 20s, and you begin to lose about 0.5 percent per year after the age of 40. If steps are not taken to combat this loss, decreased bone mineral density (osteopenia) can result. W
Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Hadied on osteoporosis children: And increased loss .Deficiencies in calcium and phosphate and disturbed balance between them are frequently encountered, and may lead to significant impairment of bone deposition. Osteopenia of prematurity - also known as neonatal rickets, rickets of prematurity or neonatal metabolic bone disease - is a common and important concern in neonatology. for topic: Osteoporosis Children
If a patient is osteopenic, his bone density level measured by T-score is between -1.0 and -2.5, states the National Osteoporosis Foundation. T-scores of -1.0 and higher, including positive T-scores,...
Results:. The prevalence of osteopenia (−1.0 SD ≥ T-score , −2.5 SD) and osteoporosis (T-score ≤ −2.5 SD) was 50% and 13% for the anterior-posterior spine, 57% and 24% for the lateral spine, and 47% and 16% for the total hip, respectively. Bone mineral density (BMD) was reduced by at least 1.0 SD at one or more skeletal sites in 92% of patients and by at least 2.5 SD in 38% of patients. Weight was the most consistent predictor of BMD at all skeletal sites. Twenty-three percent of patients were current estrogen users, and 58% were previous estrogen users. Bone mineral density did not differ by history of estrogen use at any site. ...
Background: Osteoporosis is the most common metabolic bone disease. The studys objective is to investigate the effect of an educational program based on Health Belief Model (HBM) on preventing osteoporosis in women. Methods: In this quasi-experimental study, 120 patients (60 experimental and 60 control) who were registered under the health centers in Fasa City, Fars Province, Iran, were selected in 2014. A questionnaire consisting of demographic information, HBM constructs was used to measure nutrition and walking performance for the prevention of osteoporosis before, immediately after intervention, and 6 months later. Bone mineral density (BMD) was recorded at the lumbar spine and femur before and 6 months after intervention. Results: The mean age of women participated in the study was 41.75 ± 5.4 years for the experimental group, and 41.77 ± 5.43 years for the control group. The mean body mass index was 22.44 ± 3.30 for the experimental group and 22.27 ± 3.05 for the control group. The ...
Many different clinical diagnosis overlap with the symptoms of child abuse. A keen clinical approach is necessary to ensure all children being abused are identified without over-testing or the social impact of a child abuse investigation. Ultimately a clinician must evaluate all possible reasons for findings on history and physical and make a decision about the risk probability of abuse.. The most common physical finding in child abuse is bruising. Many disease processes may mimic bruising therefore the American Academy of Pediatrics has published guidelines regarding the evaluation for bleeding disorders when child abuse is suspected. These guidelines focus on detailed medical, social and family history in addition to a full exam.. Fractures are often a concerning sign for child abuse. Rare, but possible metabolic bone diseases may place a child at a higher risk of fractures. Investigation into these disease processes as well as labs for osteopenia may be warranted in patients with multiple or ...
Osteoporosis is a highly prevalent but preventable disease and, as such, it is important that there are appropriate diagnostic criteria to identify those at risk of low trauma fracture. In 1994 the World Health Organization (WHO) introduced definitions of osteoporosis and osteopenia using T-scores, which identified 30% of all Caucasian post-menopausal women as having osteoporosis. However, the use of the WHO T-score thresholds of -2.5 for osteoporosis and -1.0 for osteopenia may be inappropriate at skeletal sites other than the spine, hip and forearm or when other modalities, such as quantitative ultrasound (QUS) are used. The aim of this study was to evaluate the age-dependence of T-scores for speed of sound (SOS) measurements at the radius, tibia, phalanx and metatarsal by use of the Sunlight Omnisense, to evaluate the prevalence of osteoporosis and osteopenia at these sites by use of the WHO criteria, and calculate appropriate equivalent T-score thresholds. The study population consisted of ...
Trauma evaluation; musculoskeletal tumors; fracture healing; arthritis; skeletal infection; osteoporosis; metabolic bone disease; bone dysplasias; growth disturbances. ...
Summary. EffRx Pharmaceuticals SA (EffRx) formerly known as EffRx, Inc is a pharmaceutical company that develops and offers novel therapies for metabolic bone disease, oncology supportive care, and pediatric conditions. The companys product Binosto/Steovess is an effervescent tablet for oral solution and for the treatment of osteoporosis. Its lead development product, EX404 targets polycystic ovarian syndrome (PCOS) in adolescents and EX113 is for the treatment of liver diseases. EFFRx also offers life cycle management services to large pharmaceutical companies. The company has collaboration with Kadmon Corporation, LLC for the development of therapies targeting adult and pediatric orphan indications. It distributes its products through distributors in the US, Australia, Korea, the Middle East and North Africa region. EffRx is headquartered in Freienbach, Switzerland.. EffRx Pharmaceuticals SA-Pharmaceuticals & Healthcare-Deals and Alliances Profile provides you comprehensive data and trend ...
... Rocaltrol is an active form of vitamin D. It is used to treat calcium deficiency with hypoparathyroidism and metabolic bone disease in people with chronic kidney failure.
Genu valgum is the Latin-derived term used to describe knock-knee deformity. While many otherwise healthy children have knock-knee deformity as a passing trait, some individuals retain or develop this deformity as a result of hereditary or genetic disorders or metabolic bone disease.
Otosclerosis is a genetically mediated metabolic bone disease that affects only the human otic capsule and ossicles. Its mode of inheritance is autosomal dominant, but penetrance and expressivity both vary.
Case Report of Twins with Metabolic Bone Disease by John Moeschler, MD; Adam Weinstein, MD; and Karen Loechner, MD Clinical Genetics Seminar: March 3, 2011 ...
Osteoporosis is a condition that affects many of us. It gradually becomes more common as we age but can also occur in those who are younger with osteoporosis-associated conditions. But what can we do about it?. Firstly lets look at what osteoporosis is.. Osteoporosis is a condition that develops slowly over several years. It causes a weakening of bones and therefore an increased risk of fractures. Osteopenia is a decrease in bone mineral density that is not yet bad enough to be categorised as osteoporosis.. So what causes osteoporosis?. Although a loss of bone mineral density is common throughout life, one of the main factors that speeds this up is menopause. Unfortunately this means that women are more likely to develop osteoporosis than men.. Other common causes and disorders linked to osteoporosis are:. ...
An enhanced form of x-ray technology used to measure bone loss, the DEXA scan provides a baseline for bone density and helps osteopenia & osteoporosis monitoring. Available at Cherry Hill, Haddonfield, Rt 73 Voorhees, Marlton, Sewell, Turnersville & West Deptford offices. Schedule bone density testing at SJRA today.
Your osteopenia workout can be a full body workout. However, when designing a workout program I always find it helpful to think of goals. With a diagnosis of osteopenia, your goal should be to maintain your bone density (if you are over the age of 30 it can usually only be maintained, it can no longer be increased), prevent falling and maintain/improve posture.. Bone forms in response to stress. This is why you may have heard that it is important for your bones that you do weight bearing exercise. This is any form of exercise which forces muscles to work against gravity. In Pilates there are hundreds of exercises which involve moving muscles against gravity. Some of my favorites are the side lying leg series, swan prepartion and modified bridges.. In order to prevent falling, it is important to work on balance. Both strength and flexability are factors that influence balance. Stretching the sides of body are important as well as the front and back of the legs and hips. There are many balance ...
What is bone disease? Why do people with HIV appear to be especially at risk? What are the signs you might be developing bone problems? In this new ...
This statistic displays the results of a survey about the share of osteoporosis and osteopenia among Indian men visiting SMS medical college and hospital in Jaipur in 2016, based on weight.
Chances are, when your doctor discussed osteoporosis or osteopenia with you, he or she said to take calcium. Some doctors will actually prescribe it in large doses, and more often
Chances are, when your doctor discussed osteoporosis or osteopenia with you, he or she said to take calcium. Some doctors will actually prescribe it in large doses, and more often
I dont quite know how to explain what happened at this appointment. It didnt go well. It felt like an interrogation, actually. First, she asked if my surgeons were satisfied with my recent DEXA scans. I told her that I wasnt sure, but I thought that they wanted me to continue on the medication, since I am still in the range of Osteopenia. She said that this was ridiculous, and with any other patient, we would be celebrating right now. She said that she would not renew my prescription for Forteo any longer, because my bones are strong enough as they are, and no reputable surgeon would require them to be any denser. The interrogation began. She started asking me questions about the reasoning for each of my surgeries and what improvements I saw with each one. Then she questioned why I was having my current surgery. She told me she thought I should consider if I really needed the surgery, and getting a different surgeon. At the very least, she thought I should see a neurosurgeon that she ...
Q: I take a water pill (diuretic) for blood pressure. Now, I have to take Boniva for osteopenia. Is there a connection? Whats next for me?
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The one-year mortality rate is consistently higher among PD patients than HD patients in Singapore; this may be due to the higher prevalence of significant comorbidities (e.g. ischaemic heart disease, cerebrovascular disease and peripheral vascular disease) among incident PD patients.(7) Studies have found that abnormal CKD-MBD parameters can affect all-cause mortality among patients on dialysis.(3-5,14,15) CKD-MBD is characterised by either one or a combination of the following items: (a) abnormalities in serum calcium, phosphorus or i-PTH levels, or vitamin D metabolism; (b) abnormalities in bone turnover, mineralisation, volume, linear growth or strength; and (c) the presence of vascular or other soft-tissue calcifications.(12) The complex relationship between abnormal CKD-MBD parameters and adverse clinical outcomes among incident PD patients has not been explored. Therefore, the present study was conducted to determine the prevalence of CKD-MBD among incident PD patients and examine the ...
One of the main determinants of who will develop osteoporosis is the amount of bone accumulated at peak bone density. There is poor agreement, however, on when peak bone density occurs. Ethnic differences were observed in age at peak bone density and their correlates. Since the diagnosis of osteoporosis and osteopaenia is based on the comparison between patients bone mineral density (BMD) and optimal peak bone density in healthy young people (T-score), it is of great importance that each country should provide its own reference peak bone density data.. This review article presents our published results on peak bone density in Croatia and compares them with findings in other populations. Our research included 18 to 25-year-old students from Zagreb University and their parents. The results showed that peak bone mass in young Croatian women was achieved before the age of twenty, but BMD continued to increase after the mid-twenties in the long-bone cortical skeleton. BMD was comparable to the ...
All three bone Gla-proteins are synthesized by the osteoblasts (the bone forming cells) and their importance became clear about 25 years ago, when it was realized that the use of vitamin K-antagonists (coumarin derivatives) in pregnant women was associated with serious bone defects in the foetus. Subsequent experiments in animals (rats, lambs) have shown that notably in rapidly growing (young) bone tissue coumarins interfere with calcium deposition resulting in excessive and irregular precipitation of calcium salts, bone deformations, growth reduction and severe osteopenia. Similar effects were observed in MGP knock-out mice. In 1984 it was shown by the group of Shearer that osteoporotic femur neck fractures were associated with very low circulation vitamin K levels. Similar data were observed by the group of Delmas. In 1989 data from our lab showed significant undercarboxylation of osteocalcin in postmenopausal women, which was normalized after vitamin K supplementation. These data, which ...
PubMed journal article The frequency of low bone mineral density and its associated risk factors in patients with inflammatory bowel disease were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Results The reduction in BMD was found in 18 (60%) pts. All of them had osteopenia (-1,T-score,-2.5). 6 pts (20%) had osteopenia of lumbar spine, 4 pts (13.3%) had osteopenia of the femoral neck, osteopenia in both areas was found in 8 pts (26.7%). In all pts with osteopenia mean T-score was -1.68±0.47 at the femoral neck and -1.92±0.46 for the lumbar spine.. Femoral neck and/or lumbar spine bone loss was found to be associated with bone marrow oedema of the SIJs and/or lumbar spine (p=0.029). No association was found between bone loss and raised C-reactive protein levels (p=0.184) or high disease activity according to BASDAI scores (p=0.703).. ...
AKUH,N has recently acquired a new state-of-the-art machine for testing Bone Mineral Density (BMD). The Dual Energy X Ray Absorptiometry (DXA) machine represents the international gold standard for BMD estimation, and is the only one of its kind in the region. The DXA emits significantly less radiation than other machines and ensures a more accurate BMD estimation. It is not only a key tool in diagnosing, preventing and treating osteoporosis, but it can also be used to evaluate a patients response to therapy, enhancing the treatment process significantly. Due to increasing awareness of osteoporosis and the incredible accuracy of the new machine, the number of patients receiving BMD testing has increased by over 30% since the introduction of the DXA machine. Our sophisticated computed radiography services support all general x-ray procedures. We can also provide digital copies of your x-rays ...
The Osteoporosis Prevention and Treatment Center specializes in the prevention, diagnosis and treatment of osteoporosis and metabolic bone disease, including postmenopausal osteoporosis, male osteoporosis, osteopenia induced by glucocorticoids, anticonvulsants and excess thyroid hormone; Pagets disease, hypercalcemia of malignancy, and hyperparathyroidism.
Dr Roderick Clifton-Bligh is Head of the Department of Endocrinology at Royal North Shore Hospital, and conjoint associate professor in Medicine at the University of Sydney. He completed a PhD in the genetics of thyroid disorders at the University of Cambridge. He now supervises dual research groups, one of which focuses on the genetics of endocrine neoplasms, and the other on metabolic bone disease.. The Cancer Genetics Unit studies the molecular bases of thyroid cancer, phaechromocytoma/paraganglioma syndromes, adrenal cancer, and pituitary neoplasms. The Metabolic Bone Research Unit studies calcium-sensing receptor gene mutations and FGF23 biology.. His scope of clinical practice remains broad. He has co-supervised 8 completed PhDs, including five Endocrinologists. He maintains a strong involvement in teaching and mentoring young physicians.. ...
This was not a blind, controlled trial, which means that only limited conclusions may be drawn about the diagnostic use of bone markers or the effectiveness of therapy, but these were not the primary aims of the study. We wished to determine whether such markers could be used to assess the response of patients on a time scale shorter than is possible with sequential bone density measurements and also whether this was related to the type of therapy or the status of the patients bones. One would expect that the treatment prescribed by the general practitioner would have some relation to the baseline condition of the patient. This was the case. In particular, bisphosphonate tended to be prescribed more often for the most osteopenic women. Nonetheless, there was a range of therapy for all BMD classes, although the numbers of women receiving HRT were disappointingly small in that they allowed only very limited statistical inferences to be made. Another weakness is that, for ethical reasons, we did ...
The second area of interest in my laboratory is the genetic origins of Pagets disease of bone. Pagets disease is a focal disorder of bone remodeling that leads to overgrowth of affected bone, which in rare cases progresses to osteosarcoma. It is the second most common metabolic bone disease after osteoporosis affecting 1-3% of the U.S. population after age 50. Approximately 20% of Pagets patients have a positive family history for the disease. Although relatively common, the etiology of Pagets disease has so far eluded researchers. Our data suggests a model in which a subset of cells might be responsible for the pagetic phenotype in the affected bone. My laboratory is interested in learning what genetic events are critical to the initiation and progression of this disease. ...
Calcitriol is vitamin D3. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body. Calcitriol is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people who have chronic kidney failure and are not receiving...
Electrolytes are minerals (magnesium, potassium, sodium, and calcium) that are lost through forms of dehydration, particularly in stress situations. Electrolyte maintains a balanced electrolyte flow within body fluids and supplies Vitamin D3 for proper calcium absorption. Vitamin D3 is vital for captive reptiles not exposed to UV-light to prevent or reverse metabolic bone disease.. Supplement for reptiles. ...
... , Arm, Elbow, Foot and Ankle, Hand and Wrist, Hip, Knee, Shoulder, Surgeon, orthopedic surgery, Arthritis, Arthroscopic Surgery, Deformity, Joint Replacement, Metabolic Bone Disease, Osteoporosis, Rehabilitation, Sports Medicine, Trauma/Fractures, Westfield, NJ
In case of acidosis the body strives to restore acid-alkaline balance by leaching the calcium from the bones. This process leads to osteoporosis
Osteoporosis and osteopenia are common issues that affect the life expectancy and quality of life in nearly 40 million Americans. These conditions, which both indicate a decrease in bone mineral density, which we can consider as bone strength, occur in men and women of all ages but are most predominate in post-menopausal women. People affected with osteoporosis or osteopenia have reduced strength and resiliency in their bones leading to an increased likelihood of fractures. Fractures are linked to significantly increased all-cause mortality in older women as well as impaired mobility and quality of life so it is imperative that bone health be maintained. One of the best ways to accomplish this is through exercise. With every muscle action and every contact with the ground, bones have some force exerted against them and they respond by becoming stronger. Increasing the amount of activity and exercise is therefore a viable way to increase bone strength. But what type of exercise will work best? A ...
My Thanksgiving Day was less stressful this year than I thought it might be, because I had my head examined the day before at Johns Hopkins at about 9:30 in the morning. By 1:30 in the afternoon, my endocrinologist there, a metabolic bone specialist, had emailed me that I was the proud parent of a…
A Dexa Scan is not recommended during pregnancy.. How the Dexa Scan is done. The scan is usually done on an outpatient basis. If the central devise is used, the patient lies on a padded table and the arm (detector) slowly passes over the body and sends information to a computer. The patient must hold very still and may be asked to hold their breath for a few seconds while the X-ray picture is being taken. The scan usually takes only 10-30 minutes. The peripheral test is simpler. The finger, hand, forearm or foot is placed in the small device and it gives the results in just a few minutes.. A trained radiologist reads and interprets the scan results as a T score or a Z score. T score shows the amount of bone you have compared with another person who is the same gender (man or woman) with peak bone mass. A score above 1 is considered normal. A Z score tells the amount of bone you have compared with other people in your age group and the same gender. ...
BeWellBuzz) Food is the key ingredient for a human being to survive, but survival isnt everything unless you combine it with healthy survival. To stay fit and healthy, we need to consume foods that are rich in nutrients that are good for our body and mind. Why Do We Need Bone-Building Foods? Bone building is a lifelong process, and if you take action now, you can ... Continue Reading ...
Definition of t score, from the Stat Trek dictionary of statistical terms and concepts. This statistics glossary includes definitions of all technical terms used on Stat Trek website.
Periodontal disease is characterized by a progressive loss of supportive gingival tissue in the gums and jawbone. It is the number one cause of tooth loss among adults in the developed world. Periodontal disease occurs when toxins found in oral plaque inflame and irritate the soft tissues surrounding the teeth. If left untreated, bacteria colonies initially cause the systematic destruction of gum tissue, and then proceed to destroy the underlying bone tissue.. Osteoporosis is a common metabolic bone disease which frequently occurs in postmenopausal women, and occurs less frequently in men. Osteoporosis is characterized by bone fragility, low bone mass and a decrease in bone mineral density. Many studies have explored and identified a connection between periodontal disease and osteoporosis.. A study conducted at the University of New York at Buffalo in 1995 concluded that post-menopausal women who suffered from osteoporosis were 86% more likely to also develop periodontal disease.. Reasons for ...
As the population is becoming more aged, osteoporosis is becoming more prevalent and the number of fragility fractures that are occurring is increasing. One of the main predictors of developing osteoporosis in later life is a bone mineral density that is greater than 2.5 standard deviations below the young adult sex-matched mean, though studies have only been able to explain 5% of the variance seen in bone mineral densities between individuals. There is now increasing evidence that the development of osteoporosis can begin in utero and that epigenetic processes, such as DNA methylation, may be central to the mechanism by which early development influences bone mineral density and later bone health. Previous work within the group has identified associations of a 300bp differentially methylated region within the CDKN2A locus with bone mineral content, bone area and areal bone mineral density in offspring from the Southampton Womens Survey(SWS) cohort. As methylation of CDKN2A increases, bone ...
We conducted a genome-wide association study of low bone mineral density (BMD) at the hip and spine utilizing sequence variants found through whole-genome sequencing of 2636 Icelanders. We found two rare missense mutations, p.Gly496Ala and p.Gly703Ser, in the COL1A2 gene that associate with measures of osteoporosis in Icelanders. Mutations in COL1A2 are known to cause the autosomal dominant disorder osteogenesis imperfecta. Both variants associate with low BMD and with osteoporotic fractures. p.Gly496Ala (frequency of 0.105%) shows the strongest association with low BMD at the spine (p = 1.8 x 10(-7) , odds ratio [OR] = 4.61 [95% confidence interval (CI) 2.59, 8.18]), whereas p.Gly703Ser (frequency of 0.050%) is most strongly associated with low BMD at the hip (p = 1.9 x 10(-8) , OR = 9.34 [95% CI 4.28, 20.3]). Association with fractures was p = 2.2 x 10(-5) , OR = 3.75 (95% CI 2.03, 6.93) and p = 0.0023, OR = 4.32 (95% CI 1.69, 11.1), respectively. The carriers of these variants do not have signs of
TY - JOUR. T1 - Dual energy X-ray absorptiometry of the knee in spinal cord injury. T2 - Methodology and correlation with quantitative computed tomography. AU - McPherson, J. G.. AU - Edwards, W. B.. AU - Prasad, A.. AU - Troy, K. L.. AU - Griffith, James W. AU - Schnitzer, Thomas J. PY - 2014/11/13. Y1 - 2014/11/13. N2 - Study Design: Comparison of diagnostic tests; methodological validation. Objectives: Primary: to investigate the precision and reliability of a knee bone mineral density (BMD) assessment protocol that uses an existing dual energy X-ray absorptiometry (DXA) forearm acquisition algorithm in individuals with spinal cord injury (SCI). Secondary: to correlate DXA-based knee areal BMD with volumetric BMD assessments derived from quantitative computed tomography (QCT). Setting: Academic medical center, Chicago, IL, USA. Methods: Participants: a convenience sample of 12 individuals with acute SCI recruited for an observational study of bone loss and 34 individuals with chronic SCI who ...
Enzyme replacement therapy: Enzyme replacement therapy is available for mucopolysaccharidoses type I (Hurler-Scheie and Scheie phenotypes), type II (Hunter syndrome), and type VI (Maroteaux-Lamy syndrome). Although enzyme replacement therapy may have systemic benefits for the patient, little evidence suggests that it favorably alters the natural history of the spinal disease. ...

Potassium Citrate - DrugBankPotassium Citrate - DrugBank

Bone Diseases / Metabolic Acidosis / Mineral Metabolism / Physical Capacity / Renal Transplant Patients. 1. ...
more infohttps://www.drugbank.ca/drugs/DB09125

What is Gorhams Disease? - Lymphangiomatosis & Gorhams Disease AllianceWhat is Gorham's Disease? - Lymphangiomatosis & Gorham's Disease Alliance

disappearing bone disease, vanishing bone disease, phantom bone disease,. massive osteolysis, disseminated osseous bone disease ... Negative hereditary, metabolic, neoplastic, immunologic, or infectious etiology.. In the early stages of the disease x-rays ... As the disease progresses bone deformity occurs with further loss of bone mass and, in the tubular bones (the long bones of the ... 2 Because of the loss of the affected bone, the condition has been referred to as disappearing bone disease, vanishing bone ...
more infohttps://www.lgdalliance.org/patient-professional-resources/what-is-gorhams-disease/

Vitamin D - Wilkinson Health Services / Non-retailVitamin D - Wilkinson Health Services / Non-retail

Metabolic bone disease is common among people with chronic liver disease, and osteoporosis accounts for the majority of cases. ... those with bone disease caused by aluminum; those with chronic liver disease; or those with bone disease associated with kidney ... metabolic syndrome (coronary heart disease), nervous system disorders, osteitis fibrosa in dialysis (soft, weak bones), pain, ... The use of substances similar to vitamin D has been found to increase bone density in people with kidney disease. The effect of ...
more infohttp://www.wilkinsonpharmacy.com/ns/DisplayMonograph.asp?storeID=CA16677413FA4D59A0FF53842F6ED4E5&DocID=bottomline-vitamind

Infantile hypophosphatasiaInfantile hypophosphatasia

... an inherited metabolic bone disease also characterized by spontaneous seizures. Initially, these seizures were attributed ... ... Machado-Joseph Disease Type 3; Machado-Joseph Disease Type 2; Machado-Joseph Disease Type 1; Lethal Ataxia With Deafness and ... Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford ... It is characterized by defective bone and tooth mineralisation associated with low serum and bone alkaline phosphatase activity ...
more infohttp://www.diseaseinfosearch.org/Infantile+hypophosphatasia/8660

Bone disease - Metabolic bone disease | Britannica.comBone disease - Metabolic bone disease | Britannica.com

Metabolic bone disease: The normal function of bone requires an adequate supply of amino acids (the building blocks for ... Skeletal disease, when it is due to inadequacies in the supply or action of the above essentials, associated with abnormalities ... Also, growth, repair, and remodeling of the bone tissue require a precisely regulated supply of hormones, vitamins, and enzymes ... outside the skeleton, is termed metabolic; in such cases the entire skeleton is affected. ...
more infohttps://www.britannica.com/science/bone-disease/Metabolic-bone-disease

Metabolic Bone Diseases | University of HelsinkiMetabolic Bone Diseases | University of Helsinki

Our aim is to enhance understanding of disease mechanisms and establish means for early diagnosis, prevention and treatment in ...
more infohttps://www.helsinki.fi/en/researchgroups/metabolic-bone-diseases

Wiley-VCH - Primer on the Metabolic Bone Diseases and Disorders of Mineral MetabolismWiley-VCH - Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

... and researchers working in the field of bone health and disease, Primer on the Metabolic Bone Diseases and Disorders of Mineral ... Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism The authoritative reference to bone diseases and ... 38 Scintigraphy and PET in Metabolic Bone Disease 302. Lorenzo Nardo, Paola A. Erba, and Benjamin L. Franc. 39 Bone ... The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone ...
more infohttps://www.wiley-vch.de/en/areas-interest/natural-sciences/life-sciences-11ls/cell-molecular-biology-11ls3/medical-cell-biology-11ls34/primer-on-the-metabolic-bone-diseases-and-disorders-of-mineral-metabolism-978-1-119-26656-3

Metabolic Bone Diseases Clinic | Tufts Medical CenterMetabolic Bone Diseases Clinic | Tufts Medical Center

Diseases Clinic at Tufts Medical Center in Boston provides care to manage increased risk for fragility fractures due to bone ... Metabolic Bone Diseases Clinic. Overview. The Metabolic Bone Diseases Clinic at Tufts Medical Center provides cutting edge care ... Throughout your time in our care, the doctors of the Metabolic Bone Diseases Clinic will take the time to get to know you so ... Title(s): Director, Metabolic Bone Diseases Clinic; Assistant Professor, Tufts University School of Medicine. Department(s): ...
more infohttps://www.tuftsmedicalcenter.org/patient-care-services/Departments-and-Services/Endocrinology/Clinical-Care-Services/Bone-and-Calcium-Metabolism-Clinic.aspx

Metabolic Bone Disease FellowshipMetabolic Bone Disease Fellowship

Each fellow will cover the monthly Metabolic Bone Disease Clinic, the weekly Metabolic Bone Disease Conference and the weekly ... The Metabolic Bone Disease Fellowship program within the combined orthopaedic, medical and radiology bone consortium represents ... The HSS Metabolic Bone Disease Fellowship is designed to provide the participant with an ongoing, in-depth experience in the ... The Metabolic Bone Disease Fellows are the primary surgeons on service cases under the supervision of the attending staff and ...
more infohttps://www.hss.edu/metabolic-bone-disease-fellowship.asp

Metabolic Bone Disease & Endocrine Calcium Center | Cleveland ClinicMetabolic Bone Disease & Endocrine Calcium Center | Cleveland Clinic

Discover how Cleveland Clinics Metabolic Bone Disease & Endocrine Calcium Center helps streamline the evaluation and treatment ... Metabolic Bone Disease & Endocrine Calcium Center Metabolic Bone Disease & Endocrine Calcium Center ... Elevated markers of bone turnover. The Metabolic Bone Disease & Endocrine Calcium Center may also provide evaluation and ... The Metabolic Bone Disease & Endocrine Calcium Center addresses problems associated with the regulation of the bodys bone, ...
more infohttps://my.clevelandclinic.org/departments/endocrinology-metabolism/depts/endocrine-calcium

Metabolic bone disease - WikipediaMetabolic bone disease - Wikipedia

... of metabolic bone disease Metabolic Bone Disease Squirrel Wildlife Rehabilitators-Metabolic Bone Disease Metabolic Bone Disease ... Metabolic bone disease is an umbrella term referring to abnormalities of bones caused by a broad spectrum of disorders. Most ... For example, genetic or hereditary hypophosphatemia may cause the metabolic bone disorder osteomalacia. Although there is ... osteoporosis osteomalacia (adults) & rickets (children) osteitis fibrosa cystica Pagets disease of bone pyramiding (turtles) ...
more infohttps://en.wikipedia.org/wiki/Metabolic_bone_disease

Metabolic Bone Disease in Heavy Drinkers | Clinical Science | Portland PressMetabolic Bone Disease in Heavy Drinkers | Clinical Science | Portland Press

B. Lalor, T.B. Counihan; Metabolic Bone Disease in Heavy Drinkers. Clin Sci (Lond) 1 September 1982; 63 (3): 43P. doi: https:// ... LncRNA MALAT1 gene polymorphisms in coronary artery disease: a case-control study in a Chinese population Biosci Rep (March, ... Relation between Hepatic Alcohol Dehydrogenase Activity and the Ascorbic Acid in Leucocytes of Patients with Liver Disease J. ... Altered HDL metabolism in metabolic disorders: insights into the therapeutic potential of HDL ...
more infohttps://portlandpress.com/clinsci/article-abstract/63/3/43P/93688/Metabolic-Bone-Disease-in-Heavy-Drinkers?redirectedFrom=fulltext

Diagnosis and Classification of Vertebral Fracture - Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism,...Diagnosis and Classification of Vertebral Fracture - Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism,...

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition , ... Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition. ... in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & ...
more infohttp://onlinelibrary.wiley.com/doi/10.1002/9781118453926.ch37/summary

Chapter 42. Genetics of Osteoporosis - Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism - Center -...Chapter 42. Genetics of Osteoporosis - Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism - Center -...

Genetics of Osteoporosis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc ... Copyright © 2008 American Society for Bone and Mineral Research. All rights reserved. ...
more infohttp://onlinelibrary.wiley.com/doi/10.1002/9780470623992.ch42/references

Myopathy and Metabolic Bone Disease. | Annals of Internal Medicine | American College of PhysiciansMyopathy and Metabolic Bone Disease. | Annals of Internal Medicine | American College of Physicians

Myopathy and Metabolic Bone Disease. Gerald Stern, M.R.C.P.; Roger Smith, M.R.C.P. ... A retrospective clinical and biochemical study of 136 patients with metabolic bone disease has shown that 6 out of 91 patients ... Stern G, Smith R. Myopathy and Metabolic Bone Disease.. Ann Intern Med. ;68:1190-1191. doi: 10.7326/0003-4819-68-5-1190_3 ... Myopathy may occur as a presenting complaint in the absence of symptoms or signs of bone disease and may deceptively simulate ...
more infohttps://annals.org/aim/article-abstract/682400/myopathy-metabolic-bone-disease

Evaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients - Full Text View - ClinicalTrials.govEvaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients - Full Text View - ClinicalTrials.gov

Evaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients. The safety and scientific validity of this ... Evaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients. Actual Study Start Date :. December 12, ... Diagnostic Test: measurements to evaluate metabolic bone disease Diagnostic Test: standard care Not Applicable ... Diagnostic Test: measurements to evaluate metabolic bone disease The participants will be evaluated for a) Mineral metabolism: ...
more infohttps://clinicaltrials.gov/ct2/show/NCT03958409

Evaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients - Full Text View - ClinicalTrials.govEvaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients - Full Text View - ClinicalTrials.gov

Evaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients. The safety and scientific validity of this ... Evaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients. Actual Study Start Date :. December 12, ... Diagnostic Test: measurements to evaluate metabolic bone disease Diagnostic Test: standard care Not Applicable ... Diagnostic Test: measurements to evaluate metabolic bone disease The participants will be evaluated for a) Mineral metabolism: ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT03958409?recrs=a&rank=44

Evaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients - Full Text View - ClinicalTrials.govEvaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients - Full Text View - ClinicalTrials.gov

Evaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients. The safety and scientific validity of this ... Evaluation and Management of Metabolic Bone Disease in Kidney Transplant Recipients. Actual Study Start Date :. December 12, ... Diagnostic Test: measurements to evaluate metabolic bone disease Diagnostic Test: standard care Not Applicable ... Diagnostic Test: measurements to evaluate metabolic bone disease The participants will be evaluated for a) Mineral metabolism: ...
more infohttps://www.clinicaltrials.gov/ct2/show/study/NCT03958409?recrs=a&view=results

Identification and treatment of metabolic bone diseaseIdentification and treatment of metabolic bone disease

Signs of metabolic bone disease include hard knobs in the long bones of the legs, bumps along the vertebral column of the back ... Metabolic bone disease (MBD) is an umbrella term that covers a number of disorders related to the weakening of the bone or ... The result is a well-functioning system, with calcium restored to and, in the case of growing animals, added to the bone matrix ... Advanced cases of MBD include all the above signs plus constipation, anorexia and fractured bones. Severely deficient reptiles ...
more infohttp://www.anapsid.org/mbd.html

Postnatal Changes in Humerus Cortical Bone Thickness Reflect the Development of Metabolic Bone Disease in Preterm InfantsPostnatal Changes in Humerus Cortical Bone Thickness Reflect the Development of Metabolic Bone Disease in Preterm Infants

... and clinical studies related to the identification of disease markers, the elucidation of their role and mechanism, as well as ... Disease Markers is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... their application in the prognosis, diagnosis and treatment of diseases. ... Postnatal Changes in Humerus Cortical Bone Thickness Reflect the Development of Metabolic Bone Disease in Preterm Infants. ...
more infohttps://www.hindawi.com/journals/dm/2016/2176594/cta/

Model for Studying the Effects of Chronic Metabolic Disease on Endogenous Bone Marrow Stem Cell Populations | SpringerLinkModel for Studying the Effects of Chronic Metabolic Disease on Endogenous Bone Marrow Stem Cell Populations | SpringerLink

Disease-associated impairment/dysfunction of stem cell populations is prominent in chronic metabolic and inflammatory diseases ... Mesenchymal stem cells Diabetes Bone marrow Osteogenesis Adipogenesis Metabolic disease This is a preview of subscription ... 2020) Model for Studying the Effects of Chronic Metabolic Disease on Endogenous Bone Marrow Stem Cell Populations. In: Guest P ... Model for Studying the Effects of Chronic Metabolic Disease on Endogenous Bone Marrow Stem Cell Populations. ...
more infohttps://link.springer.com/protocol/10.1007%2F978-1-0716-0471-7_6

MBD (Metabolic Bone Disease)MBD (Metabolic Bone Disease)

Metabolic Bone Disease symptoms Started by squirrelfriend, 02-05-2007 08:23 AM 6 Pages •. 1 2 3 ... 6 ... Pycnogenol: supports mineralization of the bones Started by Diggies Friend, 07-13-2017 10:17 PM ... MBD (Metabolic Bone Disease). * NEW to the Forum? Remember to REFRESH your screen often to see the latest responses to your ...
more infohttps://thesquirrelboard.com/forums/forumdisplay.php?168-MBD-

PRIME PubMed | Chronic kidney disease associated with decreased bone mineral density, uric acid and metabolic syndromPRIME PubMed | Chronic kidney disease associated with decreased bone mineral density, uric acid and metabolic syndrom

... uric acid and metabolic syndrom were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad. ... PubMed journal article Chronic kidney disease associated with decreased bone mineral density, ... "Chronic Kidney Disease Associated With Decreased Bone Mineral Density, Uric Acid and Metabolic Syndrome." PloS One, vol. 13, no ... Chronic Kidney Disease Associated With Decreased Bone Mineral Density, Uric Acid and Metabolic Syndrome. PLoS ONE. 2018;13(1): ...
more infohttps://www.unboundmedicine.com/medline/citation/29320555/Chronic_kidney_disease_associated_with_decreased_bone_mineral_density_uric_acid_and_metabolic_syndrome_

PTU-027 Is metabolic bone disease routinely tested for in chronic pancreatitis?PTU-027 Is metabolic bone disease routinely tested for in chronic pancreatitis?

Despite a high prevalence of metabolic bone disease, less than half of chronic pancreatitis patients were assessed. Not ... PTU-027 Is metabolic bone disease routinely tested for in chronic pancreatitis?. ... Chronic pancreatitis is associated with metabolic bone disease which increases the risk of fragility fractures. The National ... The aim of this study was to assess compliance with metabolic bone assessment in patients with chronic pancreatitis, assess the ...
more infohttps://insights.ovid.com/gutj/201806001/00003970-201806001-00312

Part I: Metabolic bone disease: Histomorphometry as a diagnostic aidPart I: Metabolic bone disease: Histomorphometry as a diagnostic aid

Biochemical markers for bone turnover for the clinical assessment of metabolic bone disease. Endocrin Metab Clin North Am 1990; ... The tissue pathological features of metabolic bone disease. Orthop Clin North Am 1984;15:613-29. [ Links ]. ... 6. Jowsey J (ed). Metabolic diseases of bone. Philadelphia: W B Saunders Company; 1977: 229-47. [ Links ]. ... Metabolic diseases affecting bone are generally diagnosed late when patients present clinically with end stage skeletal ...
more infohttp://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1681-150X2008000400006
  • Gorham's (GOR-amz) disease is a very rare skeletal condition of uncertain etiology, characterized by the uncontrolled proliferation of distended, thin-walled vascular or lymphatic channels within bone, which leads to resorption and replacement of bone with angiomas and/or fibrosis. (lgdalliance.org)
  • Abnormalities of the remaining bones of the arm and shoulder are noted and the authors report that the arteries, veins, and nerves appeared normal. (lgdalliance.org)
  • 8 That same year Gorham and Stout presented to the American Association of Physicians their paper (in abstract form), "MASSIVE OSTEOLYSIS (ACUTE SPONTANEOUS ABSORPTION OF BONE, PHANTOM BONE, DISAPPEARING BONE): Its Relation to Hemangiomatosis. (lgdalliance.org)
  • Disease-associated impairment/dysfunction of stem cell populations is prominent in chronic metabolic and inflammatory diseases, such as type 2 diabetes mellitus (DM) where the multifunctional properties (viability, proliferation, paracrine secretion, multilineage differentiation) of bone marrow resident mesenchymal stem cells (MSCs) can be affected. (springer.com)
  • We have consequently optimized the isolation and culture conditions for impaired/dysfunctional bone marrow MSCs from B6.Cg-Lep ob /J obese prediabetic mice. (springer.com)
  • Morrison SJ, Scadden DT (2014) The bone marrow niche for haematopoietic stem cells. (springer.com)
  • Schatteman GC (2004) Adult bone marrow-derived hemangioblasts, endothelial cell progenitors, and EPCs. (springer.com)
  • Polymeri A, Giannobile WV, Kaigler D (2016) Bone marrow stromal stem cells in tissue engineering and regenerative medicine. (springer.com)
  • Mangialardi G, Madeddu P (2016) Bone marrow-derived stem cells: a mixed blessing in the multifaceted world of diabetic complications. (springer.com)
  • Mehrbani Azar Y, Green R, Niesler CU, van de Vyver M (2018) Antioxidant preconditioning improves the paracrine responsiveness of bone marrow mesenchymal stem cells to diabetic wound fluid. (springer.com)
  • Briquet A, Dubois S, Bekaert S, Dolhet M, Beguin Y, Gothot A (2010) Prolonged ex vivo culture of human bone marrow mesenchymal stem cells influences their supportive activity toward NOD/SCID-repopulating cells and committed progenitor cells of B lymphoid and myeloid lineages. (springer.com)
  • Lu L, Song H-F, Zhang W-G, Liu XQ, Zhu Q, Cheng XL et al (2012) Potential role of 20S proteasome in maintaining stem cell integrity of human bone marrow stromal cells in prolonged culture expansion. (springer.com)
  • Bone marrow transplantation is currently recommended only for mucopolysaccharidosis type I (Hurler syndrome). (ispn.guide)
  • Some patients with type II disease (Hunter disease) have been successfully treated with bone marrow transplantation. (ispn.guide)
  • Bone marrow transplantation has to be performed before 2 years of age. (ispn.guide)
  • [ 15 ] The effects of bone marrow transplant in hypophosphatasia appear to be transient, as bone lesions may recur approximately 6 months after the transplantation. (medscape.com)
  • MAT, by its "specific marrow location, and its adipocyte origin from at least LepR+ marrow MSC is separated from non-bone fat storage by larger expression of bone transcription factors", and likely indicates a different fat phenotype. (wikipedia.org)
  • During aging, bone quantity declines and fat redistributes from subcutaneous to ectopic sites such as bone marrow, muscle, and liver. (wikipedia.org)
  • Until recently, qualitative measurements of MAT have relied on bone histology, which is subject to site selection bias and cannot adequately quantify the volume of fat in the marrow. (wikipedia.org)
  • Table 1 summarizes the metabolic and morphologic complications associated with HIV infection and ART. (thebodypro.com)
  • Further evaluation should focus on the specific type of kidney disease and on identifying complications related to the disease stage. (aafp.org)
  • Complications of chronic kidney disease (CKD) generally become prevalent when estimated glomerular filtration rate falls below 60 mL/min/1.73 m 2 (stage 3 CKD or greater) and become more common and severe as CKD progresses. (diabetesjournals.org)
  • Quite simply stated, vitamin D3 (dietary or derived from exposure to ultraviolet B), calcium (dietary and matter recycled from the bone matrix) and phosphorus (dietary) interact together to perform a number of functions besides bone growth and maintenance, including muscle contractions and blood coagulation. (anapsid.org)
  • Calcitriol allows absorption of calcium and phosphorus in the gut, primarily in the small intestine, and maintains the body's balance of calcium and phosphate through the kidney and bone. (faqs.org)
  • Children with metabolic bone disease frequently have multiple joint involvement, making neurological evaluation difficult. (ispn.guide)
  • Children with metabolic bone disease commonly have significant comorbidities (for example, respiratory and cardiac involvement). (ispn.guide)
  • Methods In this pilot study 14 parents of children with metabolic diseases, aged between 2.5 and 13 years, participated in a quasi-experimental pre-post-follow-up study. (bioportfolio.com)
  • Conclusions In summary it can be said that the existing Triple P-program has good effects, with a great degree of satisfaction, for parents of children with metabolic diseases in reducing dysfunctional parenting styles, parenting stress and behavioral problems of their children. (bioportfolio.com)
  • 5. Parfitt AM, Matthews CHE, Villeneuve AR, Kleerekoper M. Relationship between surface, volume and thickness of iliac trabecular bone in ageing osteoporosis. (scielo.org.za)
  • The resorption and formation processes are balanced, and remodel approximately 5% of cortical and 20% of trabecular bone each year. (frontiersin.org)
  • Bone histomorphometric analysis showed that HP rats presented low trabecular bone volume (BV/TV) independently of the uremia. (usp.br)
  • Select fellows are given the opportunity to present their research at Osteo Fellows and at the Santa Fe Bone Symposium. (endocrine.org)
  • To receive news and publication updates for Disease Markers, enter your email address in the box below. (hindawi.com)
  • The mechanisms leading to osteoarthritis development , especially the role of chemokines in cartilage and bone generation after injury, and how they affect pain response. (unc.edu)
  • I have also lead the development of EULAR ACR guidelines for PMR with joint transatlantic publication in the Annals of Rheumatic Diseases and Arthritis Rheumatology in October 2015. (spirehealthcare.com)
  • 8 In 2002, the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative published practice guidelines to help primary care physicians identify patients with early CKD and improve health outcomes. (aafp.org)
  • Since that fateful phone call, Dr. Ayoub has reviewed upwards of 3,000 pieces of medical literature, ultimately revealing to him that a great number of child abuse cases may in fact be instances of misdiagnosed metabolic dysfunction. (mercola.com)