Bone Diseases: Diseases of BONES.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Bone Diseases, MetabolicBone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Bone Resorption: Bone loss due to osteoclastic activity.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Renal Osteodystrophy: Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Osteomalacia: Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.Diphosphonates: Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Osteolysis: Dissolution of bone that particularly involves the removal or loss of calcium.Osteoclasts: A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.Bone Development: The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Osteitis Fibrosa Cystica: A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM.Osteoblasts: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.Parathyroid Hormone: A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.Alkaline Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.Fractures, Bone: Breaks in bones.Bone Matrix: Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.Osteitis Deformans: A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.Osteolysis, Essential: Syndromes of bone destruction where the cause is not obvious such as neoplasia, infection, or trauma. The destruction follows various patterns: massive (Gorham disease), multicentric (HAJDU-CHENEY SYNDROME), or carpal/tarsal.Osteogenesis: The process of bone formation. Histogenesis of bone including ossification.Aluminum: A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.RANK Ligand: A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.Bone Regeneration: Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.Ilium: The largest of three bones that make up each half of the pelvic girdle.Bone Density Conservation Agents: Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.Hyperparathyroidism: A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.Osteoprotegerin: A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.Dihydrotachysterol: A VITAMIN D that can be regarded as a reduction product of vitamin D2.Hyperparathyroidism, Secondary: Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Fractures, Spontaneous: Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)Bone Transplantation: The grafting of bone from a donor site to a recipient site.Osteocalcin: Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.Osteocytes: Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.Bone Diseases, Endocrine: Diseases of the bones related to hyperfunction or hypofunction of the endocrine glands.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Rickets: Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.Bone Morphogenetic Proteins: Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.Bone Substitutes: Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.Hypercalcemia: Abnormally high level of calcium in the blood.Strontium Isotopes: Stable strontium atoms that have the same atomic number as the element strontium, but differ in the atomic weight. Sr-84, 86, 87, and 88 are the stable strontium isotopes.Femur: The longest and largest bone of the skeleton, it is situated between the hip and the knee.Osteonecrosis: Death of a bone or part of a bone, either atraumatic or posttraumatic.Technetium Tc 99m Medronate: A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.Clodronic Acid: A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.Fibrous Dysplasia of Bone: A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).Osteopetrosis: Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).Calcification, Physiologic: Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.Receptor Activator of Nuclear Factor-kappa B: A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.Tibia: The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.Absorptiometry, Photon: A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.Renal Dialysis: Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.Calcium Metabolism Disorders: Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.Bone Morphogenetic Protein 2: A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.Minerals: Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.Pelvic Bones: Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.Potassium Citrate: A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher.Osteosclerosis: An abnormal hardening or increased density of bone tissue.Temporal Bone: Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).Hydroxycholecalciferols: Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.Vitamin D: A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.Jaw DiseasesCollagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.X-Ray Microtomography: X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.Skull: The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.Parietal Bone: One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.Bone Diseases, Infectious: Bone diseases caused by pathogenic microorganisms.Osteogenesis Imperfecta: COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.Technetium Compounds: Inorganic compounds that contain TECHNETIUM as an integral part of the molecule. Technetium 99m (m=metastable) is an isotope of technetium that has a half-life of about 6 hours. Technetium 99, which has a half-life of 210,000 years, is a decay product of technetium 99m.Alendronate: A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.Calcium Carbonate: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.Alveolar Bone Loss: Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.Bone Cements: Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Ergocalciferols: Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.Osteoporosis, Postmenopausal: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.Trapidil: A coronary vasodilator agent.Haversian System: A circular structural unit of bone tissue. It consists of a central hole, the Haversian canal through which blood vessels run, surrounded by concentric rings, called lamellae.Bone Cysts: Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.Hypophosphatemia: A condition of an abnormally low level of PHOSPHATES in the blood.Phosphates: Inorganic salts of phosphoric acid.Parathyroid Glands: Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.Mice, Inbred C57BLCalcitriol: The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.Imidazoles: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).N-substituted Glycines: AMINO ACIDS composed of GLYCINE substituted at the nitrogen rather than the usual carbon position, resulting in the loss of HYDROGEN BONDING donors. Polymers of these compounds are called PEPTOIDS.Medullary Sponge Kidney: A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.Nephrolithiasis: Formation of stones in the KIDNEY.Hypocalcemia: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)Mesenchymal Stromal Cells: Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Monoclonal Gammopathy of Undetermined Significance: Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia.Spine: The spinal or vertebral column.Femoral NeoplasmsParathyroidectomy: Excision of one or more of the parathyroid glands.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Frontal Bone: The bone that forms the frontal aspect of the skull. Its flat part forms the forehead, articulating inferiorly with the NASAL BONE and the CHEEK BONE on each side of the face.Core Binding Factor Alpha 1 Subunit: A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.OsteomyelitisAcid Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.Bone Morphogenetic Protein 7: A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Bone Marrow DiseasesCalcium, Dietary: Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.Radionuclide Imaging: The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.Lumbar Vertebrae: VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.Hyperphosphatemia: A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.Phosphorus Metabolism Disorders: Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.PHEX Phosphate Regulating Neutral Endopeptidase: A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.Cellular Microenvironment: Local surroundings with which cells interact by processing various chemical and physical signals, and by contributing their own effects to this environment.Cathepsin K: A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.Calcinosis: Pathologic deposition of calcium salts in tissues.Receptors, Tumor Necrosis Factor: Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.Hyperparathyroidism, Primary: A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.Maxillary DiseasesLeg Bones: The bones of the free part of the lower extremity in humans and of any of the four extremities in animals. It includes the FEMUR; PATELLA; TIBIA; and FIBULA.Acidosis, Renal Tubular: A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.Bone Marrow Neoplasms: Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.Bone Marrow Examination: Removal of bone marrow and evaluation of its histologic picture.Femoral Fractures: Fractures of the femur.Metacarpal Bones: The five cylindrical bones of the METACARPUS, articulating with the CARPAL BONES proximally and the PHALANGES OF FINGERS distally.Boronic Acids: Inorganic or organic compounds that contain the basic structure RB(OH)2.Vitamin D Deficiency: A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Hypophosphatasia: A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)Bone Morphogenetic Protein 4: A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.Breast Neoplasms: Tumors or cancer of the human BREAST.Metatarsal Bones: The five long bones of the METATARSUS, articulating with the TARSAL BONES proximally and the PHALANGES OF TOES distally.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Tarsal Bones: The seven bones which form the tarsus - namely, CALCANEUS; TALUS; cuboid, navicular, and the internal, middle, and external cuneiforms.Receptors, Cytoplasmic and Nuclear: Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.Receptors, CCR1: CCR receptors with specificity for a broad variety of CC CHEMOKINES. They are expressed at high levels in MONOCYTES; tissue MACROPHAGES; NEUTROPHILS; and EOSINOPHILS.Parathyroid Hormone-Related Protein: A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.Dihydroxycholecalciferols: Cholecalciferols substituted with two hydroxy groups in any position.Technetium: The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Bone Demineralization Technique: Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.Foot Bones: The TARSAL BONES; METATARSAL BONES; and PHALANGES OF TOES. The tarsal bones consists of seven bones: CALCANEUS; TALUS; cuboid; navicular; internal; middle; and external cuneiform bones. The five metatarsal bones are numbered one through five, running medial to lateral. There are 14 phalanges in each foot, the great toe has two while the other toes have three each.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Spinal DiseasesLow Density Lipoprotein Receptor-Related Protein-5: LDL-receptor related protein that combines with FRIZZLED RECEPTORS at the cell surface to form receptors that bind WNT PROTEINS. The protein plays an important role in the WNT SIGNALING PATHWAY in OSTEOBLASTS and during EMBRYONIC DEVELOPMENT.PyrazinesHypophosphatemia, Familial: An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Mice, SCID: Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.Radius: The outer shorter of the two bones of the FOREARM, lying parallel to the ULNA and partially revolving around it.Orthopedics: A surgical specialty which utilizes medical, surgical, and physical methods to treat and correct deformities, diseases, and injuries to the skeletal system, its articulations, and associated structures.Procollagen: A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.Bone Cysts, Aneurysmal: Fibrous blood-filled cyst in the bone. Although benign it can be destructive causing deformity and fractures.Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Ovariectomy: The surgical removal of one or both ovaries.Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.Bone Morphogenetic Protein 6: A bone morphogenetic protein that is a potent inducer of BONE formation. It plays additional roles in regulating CELL DIFFERENTIATION of non-osteoblastic cell types and epithelial-mesenchymal interactions.Calcifediol: The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Chondrocalcinosis: Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Bone Plates: Implantable fracture fixation devices attached to bone fragments with screws to bridge the fracture gap and shield the fracture site from stress as bone heals. (UMDNS, 1999)Osseointegration: The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).Periosteum: Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.Macrophage Colony-Stimulating Factor: A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).

Tracking adhesion factors in Staphylococcus caprae strains responsible for human bone infections following implantation of orthopaedic material. (1/59)

Ten Staphylococcus caprae strains isolated from four patients and responsible for bone infections following implantation of orthopaedic material were compared to four S. caprae strains collected from milk samples of healthy goats. The following characteristics were investigated: Smal patterns, hybridization patterns with pBA2 (ribotypes), slime production, adhesion to matrix proteins (fibrinogen, fibronectin, collagen) and the staphylococcal adhesion genes (fnbA, clfA, cna, atlE, ica, fbe). None of the characteristics enabled us to distinguish the human strains from the goat strains. Slime was occasionally produced by S. caprae strains but all of them carried nucleotide sequences hybridizing at low stringency with the following genes: atlE encoding a S. epidermidis autolysin binding vitronectin and responsible for the primary adhesion to polystyrene, ica operon involved in the biosynthesis of a S. epidermidis extracellular polysaccharide, and the part of clfA encoding the serine-aspartate repeated region of a S. aureus cell-wall fibrinogen-binding protein.  (+info)

Aspergillosis in children with cancer: A 34-year experience. (2/59)

A retrospective review of medical records, microbiology and pathology laboratory records, and nosocomial infection surveillance data was undertaken to describe the experience with culture-documented aspergillus infection in pediatric cancer patients at our facility. Sixty-six patients were identified from a 34-year period. The most common underlying diagnosis was leukemia. Risk factors included neutropenia, immunosuppression, and prior antibiotic therapy. On the basis of clinical presentation, 23 patients were believed to have disseminated disease and 43 to have localized disease. The lung was the most frequently affected organ. Despite aggressive medical and surgical management, overall mortality was 85% within the first year after diagnosis. Patients who presented with disease in sites other than the lungs fared better than patients with initial pulmonary involvement (P=.0014). Aspergillosis continues to be associated with poor outcome. Development of improved medical and adjuvant therapies, including surgery, is warranted.  (+info)

Tackling osseous hydatidosis using orthopaedic oncology techniques. (3/59)

Hydatid disease of bone is rare; success in management is difficult as recurrence is common. We report the successful use of orthopaedic oncological techniques and technology in treating a patient with hydatid disease affecting his humerus.  (+info)

Scedosporium apiospermum in chronic granulomatous disease treated with an HLA matched bone marrow transplant. (4/59)

A patient with chronic granulomatous disease who was being treated with steroids was diagnosed with a soft tissue Scedosporium apiospermum infection. Despite extensive treatment with antifungals progression to involve solid tissue (bone) occurred. Treatment required an HLA matched bone marrow transplant, which led to complete clearance of the fungal infection, although the patient subsequently died.  (+info)

Mechanism of accumulation of 99mTc-sulesomab in inflammation. (5/59)

99mTc-Sulesomab, the Fab fragment of anti-NCA-90, is used as an in vivo granulocyte labeling agent for imaging inflammation. It is not clear to what extent it targets cells that have already migrated into the interstitial space of an inflammatory lesion as opposed to circulating cells. The contribution to signal of radioprotein diffusion in the setting of increased vascular permeability is also poorly documented. METHODS: We compared the local kinetics of (99m)Tc-sulesomab and (99m)Tc-labeled human serum albumin (HSA), which have similar molecular sizes, in 7 patients with orthopedic infection proven by clearly positive (111)In-leukocyte scintigraphy. (99m)Tc-Sulesomab and (99m)Tc-HSA were administered in sequence separated by an interval of 2-6 d. Images were obtained 1, 3, 4, and 6 h after injection, and multiple venous blood samples were obtained for blood clearance measurement. Patlak-Rutland (P-R) analysis was performed to measure lesion and control tissue protein clearance. Target-to-background tissue (T/Bkg) ratios were calculated for each radioprotein and compared with the T/Bkg ratio for (111)In-leukocytes. (99m)Tc-Sulesomab binding to granulocytes was measured in vitro and ex vivo and to primed and activated granulocytes in vitro. RESULTS: After intravenous injection, <5% of the circulating radioactivity was cell bound with both radioproteins so that the P-R curves could therefore be assumed to represent extravascular uptake of free protein. The blood clearance (mean +/- SD) of sulesomab was 23.4 +/- 11.7 mL/min, approximately 5 times greater than that of HSA, for which it was 4.8 +/- 3.1 mL/min. Likewise, clearance into the lesion of sulesomab was consistently higher than that of HSA, on average about 3 times as high. Nevertheless, the T/Bkg ratios for sulesomab and HSA were similar, except at 6 h when that of HSA (2.14 +/- 0.6) was higher than that of sulesomab (1.93 +/- 0.5; P approximately 0.01). Both values were considerably less than the T/Bkg ratio on the (111)In-leukocyte images, which, at 22 h, was 12.3 +/- 5.3. Moderate clearance of sulesomab, but not HSA, was seen in the control tissue. Granulocytes bound significantly more (99m)Tc-sulesomab in vitro when primed or activated. CONCLUSION: (a) Sulesomab does not localize in inflammation as a result of binding to circulating granulocytes; (b) sulesomab is cleared into inflammation nonspecifically via increased vascular permeability; nevertheless, it may be cleared after local binding to primed granulocytes or bind to activated, migrated extravascular granulocytes; and (c) HSA produces a similar or higher T/Bkg ratio than sulesomab because sulesomab is cleared into normal tissues and because image positivity in inflammation is significantly dependent on local blood-pool expansion.  (+info)

Bone scintigraphy as an adjunct for the diagnosis of oral diseases. (6/59)

Bone scintigraphy is a very sensitive method for the detection of osteoblastic activity of the skeleton. The technique consists of imaging the uptake of bone-seeking radiopharmaceuticals, particularly technetium-99m labeled diphosphonates, in the mineral component of bone, which consists of hydroxyapatite crystals and calcium phosphate, as well as in the organic matrix such as collagen fibers. Plain radiographs, computed tomography, and magnetic resonance imaging are classified as structural imaging modalities, whereas bone scintigraphy is a functional method. In many cases, radionuclide imaging techniques are the only means by which early physiologic changes that are a direct result of biochemical alteration may be assessed, before significant bone mineral changes can be detected by other means. Since many oral diseases may cause metabolic changes in the oromaxillofacial complex, it would be of great value to use bone scintigraphy to evaluate more completely some conditions involving the bones in the region to formulate more appropriate treatment plans. Based upon the current literature, the authors discuss the possible applications of bone scintigraphy as a diagnostic and treatment planning adjunct for oral diseases. Bone scintigraphy has proven particularly useful in the study of malignant lesions and in the evaluation of vascularized bone grafts used for maxillofacial reconstructions.  (+info)

Cost-minimization analysis and audit of antibiotic management of bone and joint infections with ambulatory teicoplanin, in-patient care or outpatient oral linezolid therapy. (7/59)

Bone and joint infections are significant causes of morbidity, mortality and healthcare costs. The cost of treatment for such infections is driven primarily by the length of hospital stay. Many of these infections will require treatment with prolonged periods of parenteral antibiotic therapy. Clinicians and healthcare managers are being attracted increasingly by administering treatment in the ambulatory setting as this offers clinical, economic and quality of life advantages from both the hospital's and patient's perspective. Our retrospective audit of managing 55 treatment episodes of bone and joint infections with teicoplanin delivered in the outpatient or home setting revealed that the mean cost of care per episode of infection was less with treatment in the ambulatory setting ( pound 1749.15) compared with the in-patient setting ( pound 11 400) or compared with the hypothetical situation of treatment with oral linezolid in the home setting ( pound 2546). Teicoplanin therapeutic drug monitoring appears to be valuable in establishing optimal serum levels, which appear to correlate with good clinical outcomes. The potential for alternative day or thrice weekly dosing with teicoplanin may offer further cost advantages whilst maintaining equivalent clinical effectiveness.  (+info)

Synthesis and characterization of hydroxyapatite-ciprofloxacin delivery systems by precipitation and spray drying technique. (8/59)

This investigation synthesized and characterized hydroxyapatite (HAP) microspheres, agglomerated microspheres, and implants containing ciprofloxacin. This delivery system is to be used as an implantable drug delivery system for the treatment of bone infections. The HAP microspheres were made by chemical precipitation followed by a spray-drying technique. Agglomerated microspheres were prepared by a wet granulation process using a granulator. Implants were prepared by direct compression of the granules on a Carver press. Ciprofloxacin was analyzed by high-performance liquid chromatography. Characterization of the HAP microspheres include particle size, size distribution, physical state of the drug in the microsphere, and microstructure of the drug delivery system before and after in vitro release. The particle size, porosity, and morphology of the microspheres were dependent on viscosity and concentration of the slurry as well as the atomization pressure used during spray drying. Even at the highest drug load (2% wt/wt), the drug was present in a noncrystalline state. The drug release from the agglomerated microspheres was quick and almost complete within 1 hour. However, compressing the same amount of agglomerated microspheres into an implant greatly reduced the rate of ciprofloxacin release. Only 12% (wt/wt) of the drug was released from the implant within 1 hour. The in vitro release of ciprofloxacin from these implants follows a diffusion-controlled mechanism. This method provides a unique way of producing various shapes and drug loads of HAP microspheres that can be easily manufactured on a commercial scale.  (+info)

Staphylococcus caprae is a Gram-positive, coccus bacteria and a member of the genus Staphylococcus. S. caprae is coagulase-negative. It was originally isolated from goats (caprae means "of a goat"), but members of this species have also been isolated from human samples. S. caprae occurs as a commensal on human skin, but has also been implicated in infections of the bloodstream, urinary tract, bones, and joints. Because S. caprae is difficult to identify definitively in the laboratory, according to a study in 2014, the incidence of S. caprae in humans in under-reported. It is a coagulase-negative, DNase-positive member of the genus Staphylococcus. Usually it is associated with goats. Since 1991, a few laboratories reported that they had isolated the organism from human clinical specimens. It is now an emerging microorganism in joint and bone infections in humans. Staphylococcus was first described in 1983 by Devisee et al. based on a strain isolated from some goat milk. It can sometimes cause ...
Harrington MD. Initial oral antibiotic therapy was noninferior to IV therapy for treatment failure in orthopedic infection at 1 y. Ann Intern Med. 2019;170:JC58. doi: 10.7326/ACPJ201905210-058. Download citation file:. ...
A 14-year-old boy presented to another hospital with a clinical picture of septic arthritis. After aspiration of purulent material from the joint, empiric antibiotic treatment was initiated and an arthrotomy was performed. Antibiotic treatment was then modified to nafcillin according to microbiological sensitivity results of the isolated Staphylococcus aureus as determined by minimal inhibitory concentration testing. One week later purulent drainage recurred and open drainage had to be repeated; an abscess anterior to the joint was noted. Once again the infection failed to resolve, and the patient was transferred to our institution where a third arthrotomy had to be performed. The organism isolated at the first aspiration was reexamined and found to have a minimal bactericidal concentration to minimal inhibitory concentration ratio of 32, implying a tolerant organism. The antibiotic treatment was modified to an antibiotic not subject to the tolerance phenomenon, and the infection resolved without
by Stephen Kates (Author), Olivier Borens (Author) Written by 63 world renowned experts, "Principles" of Orthopaedic infection management takes you to the spectrum of Orthopaedic Infection from Osteomyelitis, Septic arthritis, Infection following Intramedullary nailing/plating, Periprosthetic infection. There is special emphasis on the importance of Biofilm, special methods of bacterial cultures, and diagnosis of bacterial infection. […]. ...
by Stephen Kates (Author), Olivier Borens (Author) Written by 63 world renowned experts, "Principles" of Orthopaedic infection management takes you to the spectrum of Orthopaedic Infection from Osteomyelitis, Septic arthritis, Infection following Intramedullary nailing/plating, Periprosthetic infection. There is special emphasis on the importance of Biofilm, special methods of bacterial cultures, and diagnosis of bacterial infection. […]. ...
BOZEMAN, MT, and VANCOUVER, BC--(Marketwired - June 16, 2016) - Microbion Corporation (Microbion) of Bozeman, MT, USA and Microbion Pharma Corp. of Vancouver, BC, Canada, specializing in the treatment of hard to treat and antibiotic-resistant infections, today announced that James Krieg, M.D., of Thomas Jefferson Hospital in Philadelphia, Pennsylvania, has...
Coloured X-ray (front view) of the bones of the knee of a 39 year old patient, showing the presence of bone infection (dark areas) with atypical bacteria (atypical mycobacteriosis). The bacteria were Staphylococcus aureus (37%), pneumococci (13%) and Mycobacterium tuberculosis (10%). The infection occurred after orthopaedic surgery. - Stock Image C004/1405
Reviews and ratings for claforan when used in the treatment of bone infection. Share your experience with this medication by writing a review.
Dr. Kates performs joint replacement and arthritis surgery of the hip, knee, and shoulder primarily for the middle aged and elderly patients. Additionally he cares for the elderly with fragility fractures and orthopaedic infections. His practice is focused on providing excellent care to our aging population. He is a board-certified orthopaedic surgeon, Director of the Geriatric Fracture Center, and a member of the Evarts Joint Center at Highland Hospital. He is also Professor of Orthopaedics and Rehabilitation, and Chief of the Oncology, Metabolic Bone and Geriatric Division at the University of Rochester Medical Center ...
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More severe cases of osteomyelitis require more extreme treatment. They can require surgery to scrape the infection from the bone or remove any dead parts of the bone. Your doctor may recommend a skin graft to remove infected skin and replace it with healthy skin from another part of the body. Bone grafts are another option. In a worst-case scenario, doctors may need to amputate the affected limb.. Patients should be prepared for follow-up appointments with their doctor, who might order more lab work and imaging scans to check their progress.. If your immune system is compromised, a bone infection can recur. Its important to take every measure to prevent osteomyelitis in the first place. There are several precautions you can take:. ...
The Houston Zoos newest addition, a giraffe calf named Yao Ming, is battling a life-threatening bone infection, zoo officials said. The Massai calf, born on Feb. 25, underwent arthroscopic surgery this week to remove infected bone from his right shoulder, said zoo director Rick Barongi. When the limp gradually became worse, however, zoo veterinarians X-rayed the leg and found no evidence of bone damage, officials said. Winchell determined that Yao had developed a bone infection in his right shoulder and began an aggressive treatment regimen that included flushing the joint, removing the damaged tissue and infected bone, and administering stronger antibiotics.
The invention provides a biocompatible material derived from keratin that is useful for many aspects of medical treatment of bone. The keratin material is preferably S-sulfonated and enriched in intermediate filament proteins of high molecular weight. The keratin material may be porous for use as a bone replacement and augmentation product but also provided is the use of dense keratin materials in bone treatment for use as an internal fixation appliance in the treatment of bone fractures and bone regeneration, and a method for preparing the keratin material for use in the preservation, restoration and development of form and function of bone.
Bone Infection (Osteomyelitis) Basics So youve been told you have osteomyelitis, or you might have osteomyelitis. Thats a five dollar word for bone infection. Read on to get a few facts about this condition, and where it may lead you in the short term. Staph Aureus is the most common causative organism Bone infection means that a bacteria has gotten through the … [Read more...] about 5 Facts About Osteomyelitis (Bone Infection) ...
Particles of a variety of orthopaedic materials have been implicated with bone resorption both in vivo and in vitro. The polymer investigated in this study is poly(L-lactide), a bioresorbable material which has been used in orthopaedics to manufacture screws and pins for fracture fixation. Poly(L-lactide) implants degrade and release particulate debris prior to their resorption. So far, the particles generated during the degradation of poly(L-lactide) implants have not been implicated with bone resorption in human clinical trials however, osteolysis in the vicinity of degrading resorbable implants made of a similar material known as poly(glycolide) has been observed radiographically. The biocompatibility of poly(L-lactide) particles was investigated using both in vitro and in vivo techniques in this project and the findings can be summarised as follows: 1. Exposure of fibroblasts to poly(L-lactide) particulates caused an increase in prostaglandin E2 (PGE2) release from intact viable cells ...
Part of the Manchester Tissue Regeneration & Stem Cell Network Seminar Series.. How mesenchymal stem cell fate is controlled by the cell/material interface is becoming better understood in terms of material chemistry, mechanical properties and topography. We have focused on the use of nanoscale topography to target MSC differentiation to bone with a view to design of new orthopaedic materials. However, we have also studied MSC growth without differentiation using nanotopography. This is important if we wish to expand large numbers of high quality autologous MSCs for clinical use. We have shown that control of adhesion and cytoskeletal tension is important in regulating growth through mitogen activated protein kinases and subtle alterations in cell cycle. From these observation we have gone on to develop dynamic growth platforms that allow first MSC expansion and then targeted differentiation on user demand and also to start to bioengineer 3D bioengineered MSC niches that could be useful in e.g. ...
Osteomyelitis is an infection of a bone. Symptoms include pain and tenderness over the affected area of bone, and feeling unwell. It is a serious infection...
Osteomyelitis (an infection of the bone) can be caused by a variety of microbial agents (bacteria, fungus), the most common of which is staphylococcus aureus.. This serious infection can occur from a number of sources:. ...
A great deal of research is ongoing in the area of tissue engineering (TE) for bone regeneration. A possible improvement in restoring damaged tissues involves the loading of drugs such as proteins, genes, growth factors, antibiotics, and anti-inflammatory drugs into scaffolds for tissue regeneration. This mini-review is focused on the combination of the local delivery of antibiotic agents with bone regenerative therapy for the treatment of a severe bone infection such as osteomyelitis. The review includes a brief explanation of scaffolds for bone regeneration including scaffolds characteristics and types, a focus on severe bone infections (especially osteomyelitis and its treatment), and a literature review of local antibiotic delivery by the combination of scaffolds and drug-delivery systems ...
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Osteomyelitis is an infectious process in bone that occasionally leads to bone destruction. Traditionally, the surgical treatment procedure is performed in combination with systemic and local antibiot
Sepsis represents uncontrolled inflammation due to an infection. Cold-inducible RNA-binding protein (CIRP) is a stress-induced damage-associated molecular pattern (DAMP). A subset of neutrophils expressing ICAM-1+ neutrophils was previously shown to produce high levels of reactive oxygen species. The role of CIRP for the development and function of ICAM-1+ neutrophils during sepsis is unknown. We hypothesize that CIRP induces ICAM-1 expression in neutrophils causing injury to the lungs during sepsis. Using a mouse model of cecal ligation and puncture (CLP)-induced sepsis, we found increased expression of CIRP and higher frequencies and numbers of ICAM-1+ neutrophils in the lungs ...
... is an inflammation or swelling of bone tissue. Its most often caused by an infection. Bone infection may occur for many reasons and can affect children or adults.
... is a bone infection caused by germs entering the bodys tissues through an open wound. The easiest way to prevent it is to practice good hygiene.
Osteomyelitis is a bone infection that can happen when germs enter an open wound. The easiest way to prevent it is to keep skin clean.
Infections of Bones and Joints; Pediatrics; Pediatric Infectious Diseases; Acute & Chronic Diseases and Conditions in Pediatric Patients; Bladder Infection; Bone Infection ...
We need at lot of prayer for my husband. Hes had 4 of CT Scan and One MRI. He has a bone infection in his lower back and a couple of abscess areas that are really infected. We are being sent up to the University of Washington this week to see if they will do surgery and clean up the areas. Hes had crohns for 28 years hes had 2 surgery and only has some of his small bowel left not much. He is going to one of the best surgeon at UW. I was thinking the was a long road for us but this has been long enough. 14 years ago was his first surgery today and he had a total colon and rectum removal. Some how the crohns fisucla through his back muscle and out the lower back skin. He has two holes in his intestine. Well thanks for listening tonight. Will keep u up to date ...
A Michigan man was saved when his dog alerted him to a bone infection from diabetes when he bit off the infected toe. The dog, Kiko, is currently being watched for signs of rabies, but otherwise the owner, Jerry Douthett of Rockford is thankful for his pets actions.
Immune Abnormalities; Pediatrics; Pediatric Infectious Diseases; Acute & Chronic Diseases and Conditions in Pediatric Patients; Bladder Infection; Bone Infection ...
Prairie Foot And Ankle In Elgin & Chicago, IL Offers A Wide Variety Of Podiatric Care. Visit Our Osteomyelitis (Bone Infection) Page For More Information Or Call Us Today!
Consultant Trauma and Orthopaedics Specialities: Hand and wrist surgery. Special clinical interests: Dupuytrens disease, Hand Arthritis,. Research interests: Orthopaedic infection, Dupuytrens disease. Telephone: 01603 286145 Secretary: Helen van Raalte. Current membership(s) of professional National and Regional bodies:Royal College of Surgeons of Edinburgh, British Orthopaedic Association, British Society for Surgery of the Hand.. Degrees & Universities: BM BCh University of Oxford, PhD - Staphylococcal biofilms - University of Nottingham, FRCS (Tr and Orth). GMC number: 4324032 Professional Expertise: I qualified from Oxford University and undertook surgical training in Nottingham. After working on the BBC series "The Ship" I completed a PhD on S.Aureus biofilms. I trained in Trauma and Orthopaedics in Trent before undertaking hand fellowships at the Pulvertaft Unit in Derby and an advanced training post in Sheffield. I am the lead clinician for hand trauma. Other interests include wrist ...
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PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Bacteremia, Bone infection (Osteomyelitis), Intraabdominal Infection, Joint Infection, Skin or Soft Tissue Infection, Urinary Tract ...
Mesentechs bone targeting technology allows for the development of multiple products across a wide-range of clinical conditions, from bone regeneration, to treatment of bone infections and cancers within bone.. ...
ClinDrops (clindamycin hydrochloride) for dogs and cats is indicated for infections of skin and oral tissues and bone infections. Inhibits of protein synthesis in bacterial cell with activity against a wide variety of aerobic and anaerobic bacteria.
Replied on 04/19/2011 First I would place an Elizabethan collar around your dogs neck so that he cannot reach the sore site. Is he using his leg normally and can he feel pain below the area that was injured? If he has lost pain perception in his leg or foot and the nerves are trying to regrow then he will have a constant tingling sensation (like when your foot "falls asleep" because you sit on it too long). He wont understand that feeling and he will lick until the sensation stops. This may take months to resolve. Because the wound is now down to his bone a bone infection is a huge concern. He definitely needs oral antibiotics and likely debridement surgery to clean the wound before the infection worsens and close it.. Its time to get him back to his veterinarian or seek a second opinion before this becomes an unsolvable problem.. ...
Ciplox 500 mg (amoxicillin 500) capsule is use for treat for bacterial infections like joint and bone infections and salt of ciplox is Amoxycillin. Buy Ciplox 500 mg capsule online from PremiumRXdrugs
Cipro is a quinolone antibiotic. It is used to kill bacterias or hamper their growth. Ciprofloxacin can be used for treating different kinds of infections, like urinary, respiratory, skin, gastrointestinal, and bone infections. It will not be effective against colds, flu, or other viral infections. | Imedicine-online.com
in A définir (2017). Long bone fracture constitutes a common reason for medical consultation within veterinary orthopedic services (Miller et al. 1998; Kumar et al. 2007). Canine bone fracture repair differs from the human ... [more ▼]. Long bone fracture constitutes a common reason for medical consultation within veterinary orthopedic services (Miller et al. 1998; Kumar et al. 2007). Canine bone fracture repair differs from the human case in the sense that (1) the physiological characteristics and morphology of the injured bones in animals vary considerably (Palierne et al. 2006), (2) the animal is not able to limit its activity during the post-operative period, leading to premature overloading, and (3) the surgeon is confronted to cost limitations concerning orthopedic material. There is a lack of studies assessing the effect of different treatment types on the biomechanical properties of a reconstructed bone, which may partly explain the frequent associated complications in the field of ...
The JVL Research Center, located on Orthopaedic Hospitals downtown campus, is one of two research components of the UCLA and Orthopaedic Hospital Department of Orthopaedic Surgery. The mission of the JVL Research Center is to develop a deeper understanding of the biology and biomechanics of the musculoskeletal system, and to apply this knowledge to the improvement of orthopaedic materials, implants, surgical instrumentation and surgical techniques, thereby improving the quality of care to orthopaedic patients world-wide.. Learn More ...
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Osteomyelitis is inflammation of the bone caused by an infecting organism. Although bone is normally resistant to bacterial colonization, events such as trauma, surgery, presence of foreign bodies, or prostheses may disrupt bony integrity and lead to the onset of bone infection.
Looking for online definition of S.caprae in the Medical Dictionary? S.caprae explanation free. What is S.caprae? Meaning of S.caprae medical term. What does S.caprae mean?
Antirobe Caps are a highly effective antibiotic used to treat soft tissue infections (infected wounds and abscesses), dental infections (infected mouth cavity), and bone infections (osteomyelitis) in cats and dogs. This particular medication is one of the most commonly prescribed antibiotics for pets. Antirobe Caps work by penetrating the source of the bacterial infection and suppressing further protein synthesis and growth ...
The pilot will generate a novel classification system of post-surgery complications within fracture treatment to identify improvement potentials with regard to innovative products, services and technologies. Next to minor complications influencing length of treatment or quality aspects, the three major complications "bone infection", "bone non-union" and "bone misalignment" will be evaluated in the hospitals over a defined time frame of three months inclusion period and six months evaluation.. With the new EU Medical Device Regulations hospitals/doctors as well as manufacturers will have to make alterations to ensure implant safety. To meet this new requirements, the present pilot includes a MDR (Medical Device Regulation) sub-study. This study will provide information on how to ensure a constant monitoring of complications and irregularities occurring during the treatment of patients to assure patient safety and manufacturers data access. In this way, the study will support the improvement of ...
For patients having a bone or joint infections, with or without device, optimal surgical therapy could be sometimes non-feasible, especially in the elderly population. Therefore, a medical therapy with oral prolonged suppressive antibiotic therapy (PSAT) seems to be an option to prevent recurrence and prosthesis loosening.. Subcutaneous (SC) administration of injectable intravenous antibiotics as prolonged suppressive antibiotic therapy could be a convenient way when oral treatment is not available to facilitate ambulatory care, this practice being considered as routine care.. The aim of this study is to evaluate tolerance and efficacy of subcutaneous administration of antibiotics for prolonged suppressive antibiotic therapy in patients having this treatment as part of their routine care. ...
/PRNewswire/ -- BONESUPPORT™, an emerging leader in injectable bone substitutes for orthopedic trauma, bone infections and instrument augmentation related to...
Pony Girl, she is a Quarter Horse/Thoroughbred cross. Her mama was a registered Paint mare with beautiful color. Her daddy was a money winning racehorse, The Comic. She was only 23 (she would have been 24 this year) but had problem feet. She had a bone infection in a front foot that was manageable for a while then just festered. Until the last week her, her body condition and attitude/spirit were great, that foot just got the best of her. She was in a lot of pain, so it was almost easy to let her go. Honestly, the family felt better once she was laid to rest, knowing that she was no longer suffering. But, its still not the same knowing shes gone. As a kid, you think they will be here forever. Thanks for asking.. ReplyDelete ...
1 Answer - Posted in: keflex, sulfatrim, diabetes, type 2, bone infection - Answer: It can work quite well for connective tissue problems (and ulcers ...
This trial is investigating the efficacy of gentamicin impregnated sponge [Collatamp] in patients with peri-prosthetic joint infection after a joint replacement
Generic Flagyl is a high-class medication which is taken in treatment and termination of serious bacterial diseases such as skin, vagina, gastrointestinal tract, stomach, joints infections. Generic Flagyl successfully wards off and terminates other infect
Background:Outpatient parenteral antibiotic therapy (OPAT) programmes have become prevalent over the past 2 decades. From the US perspective, these programmes have been shown to reduce healthcare...
Hemicorporectomy rarely has been performed because of the very limited indications for the procedure, said senior author Dr. Robert McClelland, professor emeritus of surgery at UT Southwestern.. "An increasing number of veterans of Iraq and Afghanistan conflicts are surviving very severe injuries that frequently lead to permanent paraplegia and are often complicated by severe bedsores and intractable bone infection, which is potential a source of fatal sepsis. Because of this, the frequency of indications for hemicorporectomy may soon increase significantly," Dr. McClelland said.. Only 57 cases of translumbar amputations had been recorded in medical literature worldwide, although the researchers suspect more have occurred since the initial referencing in 1960. The authors added to their review nine UT Southwestern patients who had received the procedure as a result of terminal pelvic osteomyelitis, a type of bone infection.. About a third of the 66 patients survived at least nine years after ...
​What treatments are available for spinal infections? Learn about different types of infections, symptoms and possible treatments in this neurosurgeon-edited information page.
/PRNewswire/ -- BONESUPPORT™, an emerging leader in injectable bone substitutes for orthopedic trauma, bone infections and instrument augmentation related to...
Dr. Bertram and collaborators work in the development and analysis of mathematical models of Pancreatic beta-cell activity as well as potential methods for islet syncrhonization. This research is important in studying about diabetes. Also Dr. Bertram develops models for Hypothalamic control of hormone secretion, electrical impulses in nerve cells, and neural network controlling of bird song. Dr. Hurdals research involves investigating, modelling and visualizing information related to the way the human brain functions. Sources of data include (but are not limited to) MRI (magnetic resonance imaging) scans and EEG (electroencephalography) data. Dr. Cogans research primarily focuses on understanding clinically or industrial relevant diseases. These include Pierces disease that strikes grapevines, the bone infection osteomyelitis, plaque formation associated with Alzheimers disease and others. His group looks for treatment protocols as well as more basic questions regarding the dynamics of the ...
Includes rattletrap and rare side effects information for adults and healthcare professionals. Free 2-day shipping on adverse orders over Buy TYLENOL® Bidirectional Strength Caplets, Fever Reducer and Share Reliever, mg, ct. at [Night]1 Answer - Posted in: does wellbutrin show up in a drug screen, exit infection, cephalexin - Answer: Yes, cephalexin can be happy to treat tooth abscess and gum secreta. 12 Pounds - Posted in: infections, bone infection, accelerate, cephalexin - Answer: The cephalexin is more enough for it. I cant tolerate what antibiotics I was given for my patients I have clindamycin and cephalexin. I was offered a job contingent upon a drug test. I just happened to start budeprion sr mg on the same day I took the test. Is this going to show up positive for drugs? I get conflicting info. on the net. I do know they check for perscriptions for example someone who abuses hydrocodone. I dont take any other. I got a note from my dr to help my case but someone needs to do something ...
Have it evaluated. Such injuries can potentially be dangerous as one may develop tetanus, or a number of other types of deep infections. Wounds resulting from human or animal bites may be especially prone to infection. If the wound was deep enough they may lead to bone infections. If you develop pain, redness, swelling or other signs of infection seek medical attention ...
Pediatric orthopedics at Kasturi hospitals, India is known for its treatment for bone and joint infections in children which is caused due to Bacterium.
The secret is out... experts are predicting 458 million of these types of devices will be sold per year. 1 hyper-growth company stands to rake in maximum profit - and its NOT Apple. Show me Apples new smart gizmo! ...
Dr Anuj Patel offers treatment for epidural abscess, spine bone infection and spinal cord abscess in Hiram, Marietta and Atlanta, GA.
Scedosporium apiospermum and S. prolificans are fungi of increasing clinical importance, particularly in persons with underlying diseases. We reviewed the records of 59 patients in Australia from whom Scedosporium spp. were isolated from June 30, 1997, through December 31, 2003. S. apiospermum was isolated predominantly from the respiratory tracts of 28 of 31 patients with underlying lung diseases and resulted in 2 infections and 1 death. The annual number of S. apiospermum isolates remained constant. S. prolificans was isolated from 28 patients only after November 1999. Eight patients with acute myeloid leukemia or hematopoietic stem cell transplants had invasive infection; 4 had fungemia and 6 died from infection. S. prolificans caused locally invasive infection in 2 immunocompetent patients and was found in the respiratory tract of 18 patients with underlying respiratory disease but did not cause fungemia or deaths in these patients. Scedosporium spp. showed distinct clinical and epidemiologic
WHO REALLY NEEDS PARENTERAL ANTIBIOTICS? Bioavailability and Pharmacodynamic Issues of Oral Antibiotics Availability of Oral Products Host Factors to Consider in the Choice of Oral or Parenteral Antibiotics Antibiotic Susceptibility Profiles Oral Agents for Severe Infections Conclusions Bibliography Although much has been written concerning the indications, abuses, and recommended dosing regimens of antibiotics for many…
A bone scan is a nuclear imaging test that helps diagnose and track several types of bone disease. Your doctor may order a bone scan if you have unexplained skeletal pain suggesting bone loss, bone infection or a bone injury undetectable on a standard X-ray.
I have a follow-up appointment tomorrow. The problem with cellulitis is that if it is not treated promptly, it can go into the bone or the blood stream and cause serious complications like osteomyelitis (bone infection), meningitis (i.e. if your eye region has cellulitis), amputation (my poor toe!), sepsis (blood poisoning), or even death. All of those things are rare, but I like to be dramatic. Sorry, it is true. Drama ...
Arthritis is often a shared problem and today most of the people have problems with this issue. It is the main cause of pain which causes disability among the victim. It is related to an inflammation of the joints and the patients suffering from this problem may suffer from different types of signs such as puffiness, tenderness, warmth, stiffness, redness of skin around the ailing joints. Osteoarthritis, rheumatoid arthritis and gout are the main types of arthritis. The main cause of the osteoarthritis is the cartilage degeneration and loss which results in bone friction and also deterioration of joints. There are some factors which are responsible to be able to result in osteoarthritis tend to be aging, obesity, bone injuries and bone infection ...
Last June I had problems with an ulcer on my leg that would not heal (of course) and spent the summer not being able to use my prosthesis. I was making regular visits to the wound clinic and my PCP. After months of treatment and no real healing I was sent to a wound surgeon and in October I had surgery to remove a portion of my tibia. Ouch. I had developed a bone infection so the bone had to go. Afterwards I was attached, or tethered, to a wound vac. This is a device that uses negative pressure to heal a wound from the inside out instead of the other way around. There is tubing that runs from the vac, about the size of a purse, to the wound...24/7. The tubing is about three feet long and cannot be detached. It has only enough leeway to allow me to lay on my back in bed, sit in a wheelchair or use the commode. Yeah, the commode. This has been a long six weeks but there has been some improvement...a little at a time. It is estimated that I will be tethered until March at the least and then I will ...
A chronic wound doesnt respond to standard treatment in 30 days. Learn more about our treatment for bone infections, diabetic ulcers, and surgical wounds.
Erstellt am18. Mai 2020 Dear valued colleagues, A new video is now available on our YouTube Channel "Infectious Diseases in Motion". Our research physician Jannik Stemler presents prognostic factors and treatment strategies of invasive infections with Scedosporium spp. and Lomentospora prolificans, emerging pathogens associated with high mortality rates. Video: https://www.youtube.com/watch?v=PAe9_CKtLxQ Publication: https://bit.ly/2zxywgM We hope you enjoy watching! With best […]. Weiterlesen ...
disk spaces. D, The patient underwent CT-guided biopsy and aspiration with placement of a pigtail catheter for 1 week to drain ...
Flagyl is an antiinfective. It is used for the treatment of many kinds of infections, including respiratory, skin, gastrointestinal, as well as bone and joint infections. It will not work for colds, flu, or other viral infections. | Goodpillsnorx.com
Flagyl is an antiinfective. It is used for the treatment of many kinds of infections, including respiratory, skin, gastrointestinal, as well as bone and joint infections. It will not work for colds, flu, or other viral infections. | Atopy-pharmacy.com
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The antimicrobial properties of silver combined with a biodegradable scaffold that can be seeded with bone-forming stem cells offers a potential implant system for treating and preventing bone infection, as described in an article published in Tissue Engineering, Part A, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Tissue Engineering website until February 4, 2017. Mahsa Mohiti-Asli, PhD and coauthors from University of North Carolina at Chapel Hill, North Carolina State University (Raleigh), Silpakorn University (Nakornpathom, Thailand), and University of Missouri (Columbia), present an experiment in which they seeded bone-forming stem cells on three-dimensional scaffolds either with or without MRSA. The researchers assessed bacterial biofilm formation to determine the effect of silver ions on bone infection (osteomyelitis). They report their findings in the article entitled "Evaluation of Silver Ion-Releasing Scaffolds in a 3D Coculture ...
Intravenous literature: Dryden, M., Saeed, K., Townsend, R., Winnard, C., Bourne, S., Parker, N., Coia, J., Jones, B., Lawson, W., Wade, P., Howard, P. and Marshall, S. (2012) Antibiotic stewardship and early discharge from hospital: impact of a structured approach to antimicrobial management. The Journal of Antimicrobial Chemotherapy. 67(9), p.2289-96.. Abstract:. OBJECTIVES: To assess the impact of an infection team review of patients receiving antibiotics in six hospitals across the UK and to establish the suitability of these patients for continued care in the community.. METHODS: An evaluation audit tool was used to assess all patients on antibiotic treatment on acute wards on a given day. Clinical and antibiotic use data were collected by an infection team (doctor, nurse and antibiotic pharmacist). Assessments were made of the requirement for continuing antibiotic treatment, route and duration [including intravenous (iv)/oral switch]and of the suitability of the patients for discharge from ...
Colour enhanced scanning electron micrograph (SEM) depicting numerous clumps of methicillin-resistant Staphylococcus aureus (MRSA) bacteria. Recognized outbreaks or clusters of MRSA in community settings have been associated with strains that have some unique microbiologic and genetic properties, compared with the traditional hospital-based MRSA strains, e.g., virulence factors like toxins, which may allow the community strains to spread more easily, or cause more skin disease. MSRA infections (bloodstream, pneumonia, bone infections) occur most frequently among people with a weakened immune system in hospitals, healthcare facilities, nursing homes, and dialysis centers. The manifestation of MRSA infections acquired by otherwise healthy individuals first began to emerged in the mid- to late-1990s. These infections in the community are usually manifested as minor skin infections such as pimples and boils. Magnification: 9560x - Stock Image B234/0167
A pressure injury on the skin is caused by constant pressure to that area. This often occurs when a person lies in bed or sits in a chair for a long time. Pressure reduces blood supply to the skin. Over time, this can cause the skin to break down and form an open sore. Pressure injuries are also called bed sores or pressure ulcers.. Pressure injuries can range from red areas on the surface of the skin to severe tissue damage that goes deep into muscle and bone. They usually form over bony areas such as the hips, lower back, elbows, and heels. They may also occur in places where the skin folds over itself or where medical equipment puts pressure on the skin, such as where oxygen tubing presses on the ears or cheeks.. Pressure injuries can be hard to treat and slow to heal. If they dont heal properly, they can lead to problems such as skin infection or bone infection.. If you or someone you care for is not able to move much, its important to prevent sores and to check the skin every day. If you ...
The woman was in her 70s when she arrived at a hospital in August 2016 with signs of sepsis. She had been in India years before and had been treated for a broken leg and bone infection, according to the CDC. After doing tests, her doctors found the bacteria - which belong to a class of drug-resistant bugs called carbapenem-resistant Enterobacteriaceae (CRE) - were resistant to all forms of FDA-approved antibiotics. The patient died in September after going into septic shock, according to the CDC ...
Joint infections - Sacroiliac joint pain due to bacterial infection: a report.... Joint Advance is a natural formula designed to shield your joints from the trials and results of working hard and playing hard.
Eradication of prosthetic hip and knee joint infections is challenging, with failure rates |20% even in the setting of complete prosthesis removal.
Research question: If adults with bone or joint infection have local antibiotic therapy, can they do without prolonged treatment with antibiotics by mouth (oral) or injection?. Adults with bone or joint infections are usually given long courses of oral antibiotics or into a vein (intravenous) following surgery. It is also safe to give antibiotics directly into the bone or joint at the time of surgery: this is called local antibiotic therapy. This study investigates whether using local antibiotic therapy would allow shorter courses of oral or intravenous antibiotics, in order to limit antibiotic resistance, side effects and cost.. This study compares short against long courses of oral or intravenous antibiotics for adults who have been given appropriate local antibiotic therapy to treat bone or joint infection. Patients who can take part will be randomly divided into two groups within 7 days of surgery. One group will stop oral or intravenous antibiotics, while the other group will continue for 4 ...
A joint infection, or septic arthritis, is the inflammation of an affected joint as the body responds to an infection. Joint infections typically affect large joints in the body such as the knee or hip, however, in some instances the infection may affect several joints. If youre experiencing pain after a hip or knee surgery, you may have an infection.. ...
We look forward to welcoming you to the 36th Annual Meeting of the European Bone and Joint Infection Society which will be held in Nantes, France on 7-9 September 2017. The conference will be held in the La Cité - Nantes Events Center in France.
Flagyl is an antiinfective. It is used for the treatment of many kinds of infections, including respiratory, skin, gastrointestinal, as well as bone and joint infections. It will not work for colds, flu, or other viral infections. | Farmacialoja.xyz
The findings of the present study suggest that patients with isolated SA at presentation may later show bone lesions in the metaphysis suggestive of secondary osteomyelitis. A direct correlation seems to exist between a decreased perfusion of the femoral epiphysis on MRI in children below the age of 12 months and the later onset of osseous lesions in the metaphysis consistent with AHO on follow-up. In our experience, the type of germ involved influences neither the enhancement pattern nor the outcome. According to the recent literature, decreased perfusion of the femoral epiphysis on enhanced fat- suppressed T1-weighted MRI has already been described, but it was until now considered as a usual finding of SA [9-11], and in no case interpreted as a sign suggestive of a bone infection of the epiphysis. One study reported that epiphyseal cartilage enhancement defects may occur in the setting of AHO, but its significance was not investigated and remained uncertain. [20] In fact, SA is classically ...
This particular case involved 66-year-old B. L., who went into the hospital with a urinary tract infection, was overdosed with a blood thinner, suffered a massive abdominal bleed, died and was revived. After being revived, B.L. underwent three surgeries to find and repair the bleed, contracting MRSA osteomyelitis (bone infection) in her clavicle. She had two surgeries on the abscess and a third surgery to remove part of her clavicle bone, after which she contracted C-Diff (another bacterial infection) that caused very uncomfortable intestinal complications. She left the hospital 75 days later wheelchair bound and in a terribly deconditioned state. Four years later, the abdominal incision from the three surgeries herniated, and the entire contents of her abdomen (her bowels, intestines, some organs) pushed through the abdominal wall to sit just under her skin in a large mound. ...
If your child has started limping, find out if theyve injured their leg or foot or stood on something sharp. Inspect the soles of their feet and in between their toes for a wound or blister.. You may need to take your child to a minor injury unit. Go to your nearest accident and emergency (A&E) department if your child has a severe injury or cant put any weight on their leg.. If theres no wound or sign of injury, your child may have an underlying medical condition that needs investigating by your GP. This will usually be done by arranging blood tests and an X-ray of your childs hip.. If your child also has a fever or seems unwell, take them to your GP as soon as possible. Theyll need to be seen urgently by a specialist to rule out a bone infection (osteomyelitis).. ...
BIL had a piece of skin loose on his toe. Pulled it off. Couldt feel it due to Diabetic Neuropathy. Subsequent infections and bone infection led to toe amputation hybaric chamber treatments antibiotics infusions in the hospital a large open wound on foot and lose of second toe. After about a year Dr released him. He wore tennis shoes or whatever the descriptive label is, like so many Folks. Sweat and bacteria caused the problem and then MRSA from pet dog ...
PORTSMOUTH Glen Talon is a disabled Army veteran who has been living out of motels for the last year and a half.Talon said his motivation to serve his country came from his father, Norman, who served in the Korean War. Talon instilled the same patriotic fervor in his son, Jason, who served in the Iraq War, but Talon himself said he has fallen on hard time times following complications from surgery that left him with bone infections, leading doctors to amputate both his legs. I have
Lil Bub, one of the internets favorite, most beloved cats, died on Dec. 1. She was 8 years old. Her owner Mike Bridavsky shared the news on Monday. Lil Bub had been battling a bone infection at the time of her death. On the morning of Sunday, December 1st 2019, we lost the purest, kindest and most magical living force on our planet, he wrote. Bub was cheerful and full of love laying in our bed with us Saturday night, but unexpectedly passed away peacefully in her sleep.
Background: There are limited data detailing the appropriate management of nondisposable autologous osteoarticular fragments that have been contaminated by the operating room floor. The goal of the present study was to perform a comprehensive, three-phase investigation to establish an appropriate intraoperative algorithm for the management of the acutely contaminated, but nondisposable, autologous osteoarticular bone fragment. Methods: Phase I of the study was performed to quantify the rate of contamination and microbial profile of human osteoarticular fragments that were dropped onto the operating room floor (n = 162). Phase II was performed to assess the feasibility and optimal means of decontaminating 340 similar fragments that underwent controlled contamination with bacteria that were identified in Phase I; decontamination was performed with use of cleansing agents that are routinely available in an operating room. Phase Ill was performed to assess the effect of each decontamination process ...
駒場 大峰 , 井垣 直哉 , 高嶋 基嗣 , 後藤 俊介 , 土居 久子 , 門口 啓 , 竹本 利行 , 田中 真紀 , 前田 賢吾 , 来田 和久 , 杉本 裕 , 廣末 好昭 , 玉田 文彦 , 後藤 武男 日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 38(7), 1361-1366, 2005-07-28 参考文献11件 被引用文献1件 ...
BACKGROUND:The aim of this study was to investigate the success rate of fungal peri-prosthetic joint infection treated by 2-stage revision and related factors of treatment failure to offer a better treatment protocol. MATERIAL AND METHODS:We reviewed...
We present a case series of patients undergoing OPAT care being treated by either teicoplanin-based or ceftriaxone-based antibiotic regimens
This page includes the following topics and synonyms: Spinal Infection, Spinal Cord Infection, Spinal Osteomyelitis, Spinal Epidural Abscess, Epidural Abscess, Discitis.
The Houston Zoos newest addition, a giraffe calf named Yao Ming, is in the fight of his life, zoo official said. The 25-day-old Massai calf underwent arthroscopic surgery on Thursday to remove infected bone from his right shoulder, said Zoo Director Rick Barongi. When the limp gradually became worse, however, zoo veterinarians X-rayed the leg and found no evidence of bone damage, officials said. Winchell determined that Yao had developed a bone infection in his right shoulder, and immediately began an aggressive treatment regime that included flushing the joint, removing the damaged tissue and infected bone, as well as administering stronger antibiotics.
Bayfront Health St. Petersburgs outpatient hyperbaric medicine treatment options surround patients with difficult wounds with 100% oxygen in a comfortable, pressurized chamber. This saturation promotes the bodys natural immune system and healing responses, allowing wounds to heal more easily, from the inside out.. Hyperbaric oxygen treatments are beneficial for patients who have certain types of complicated or slow-healing wounds, such as bone infections or diabetic foot ulcers. The treatments work in conjunction with other treatments, such as antibiotics, to accelerate the healing process.. Our wound care specialists may use hyperbaric oxygen therapy to treat conditions such as:. ...
dJ THE \ . -- j ;: ::: :i -:::.. ., .,- - , / 0 0 ..00 I 1/\, / - / rm 1/,1\ \\ . . \ . o .,.,- THE, TALK OF THE, TOWN Notes and Comment A FORTY-SIXTH STREET book- seller has marked down a vol- ume entitled We Can Do Business with Russia from two dollars and a half to twenty-five cents. ^ N American basking in connubial fl. bliss, thrift account started, libido s(cure, is, roughly, ten per cent more susceptible than his celibate counterpart to gall-bladder trouble, bone infections, arthritis, varicose veins, hydrocele, sud- den onslaughts of strabismus, and other infirmities requiring hospital care. Once the vows have been exchanged, the honeymoon started in languorous old Bermuda, a fellows standing as a medl- cal risk slumps sharply. So, too, does hIS brides. We got our dope from a group- hospital-insurance prospectus of the Blue Cross, an outfit with a sound repu- tation in actuarial circles. Its monthly premium for an individual is $1.24; for a husband and wife, $2.72. Thus, when two ...
Bone loss and osteoclastogenesis are induced by inflammation in infectious and autoimmune diseases. A recent study has ... Its has been shown to be involved in the onset of many diseases, which includes Inflammatory bowel disease. Recent studies have ... Activation of these genes results in robust osteoclast formation and bone loss. This process is absent in TLR5 knockout mice ... TLR5 may play a role in inflammatory bowel disease (IBD). TLR5-deficient mice develop spontaneous colitis and metabolic ...
Its areas of focus include study of infectious diseases, biodefense, military medicine, battlefield medicine, and bone marrow ... The Infectious Diseases Directorate conducts research on infectious diseases that are considered to be significant threats to ... The Naval Infectious Diseases Diagnostic Laboratory (NIDDL) is also located in the Silver Spring facility. NIDDL provides ... "Naval Infectious Diseases Diagnostic Laboratory". U.S. Naval Medical Research Center. Retrieved 25 July 2014. "NMRC Subordinate ...
Bone marrow testing is the most accurate.[5] Symptoms are similar to that of many other infectious diseases.[6] Typhus is a ... Anna E. Newton (2014). "3 Infectious Diseases Related To Travel". CDC health information for international travel 2014 : the ... Alan J. Magill (2013). Hunter's tropical medicine and emerging infectious diseases (9th ed.). London: Saunders/Elsevier. pp. ... involved in infectious diseases multiplied in the intestines of the sick, were present in their excretions, and could be ...
Bone-marrow testing is the most accurate.[4] Symptoms are similar to that of many other infectious diseases.[3] Typhus is an ... Clinical Infectious Diseases. 45: S24-S28. doi:10.1086/518141. PMID 17582564.. *^ a b Whitaker, J. A.; Franco-Paredes, C.; Del ... Alan J. Magill (2013). Hunter's tropical medicine and emerging infectious diseases (9th ed.). London: Saunders/Elsevier. pp. ... "Water-related Diseases." Communicable Diseases 2001. World Health Organization. 31 Oct 2008 ,. "Archived copy". Archived from ...
... is focusing its efforts to 8 fields of immunodiagnostics: Infectious diseases, Bone and Mineral, Endocrinology, ... The company is also active in molecular diagnostics for infectious diseases and for the detection of some forms of Leukemia. ...
It causes disease in the joints, bones and respiratory system of birds. It is found throughout the world and infection may be ... referred to as Infectious Synovitis, Avian Mycoplasmosis, Infectious Sinusitis and Mycoplasma Arthritis. It is of economic ... The disease is most commonly seen in chickens, and transmission occurs both vertically and horizontally. Common clinical signs ... The disease is controlled with vaccination. Mycoplasma Mycoplasma synoviae, expert reviewed and published by Wikivet at http:// ...
Stopping the spread of infectious disease was of utmost importance for maintaining a healthy society. The outbreak of disease ... Among his contributions to medicine was a textbook on the treatment of wounds, broken bones, and even tumors. ... Infectious Diseases in an Age of Change The Impact of Human Ecology and Behavior on Disease Transmission. National Academies ... This will be demonstrated through discussion of the major diseases of each continent. These diseases are sociologically ...
Infectious, such as Lyme disease and osteomyelitis. Neurological, such as spinal cord injury and vertebral degeneration. ... that innervate bone tissue leads to the sensation of bone pain. Bone pain originates from both the periosteum and the bone ... and other bone diseases. Thus there are several types of bone pain, each with many potential sources or origins of cause. From ... Paget's disease of bone (also termed osteitis deformans or ambiguously, just Paget's disease). Pain caused by cancer within ...
Infectious Diseases and Pathology of Reptiles. CRC Press. p. 7. ISBN 0-8493-2321-5. ISBN 9780849323218. Retrieved 2009-01-09. ... Pelvic girdle Right hip bone. Internal surface. Right hip bone. External surface. (Body of ilium is the top of the blue circle ... The brevis shelf is the bony ridge at the inner side of the fossa, the bone wall forming the internal face of the rear part of ... Crest of ilium is labeled at top.) Plan of ossification of the hip bone. Left hip-joint, opened by removing the floor of the ...
Introduced Infectious Diseases and Population Decline among Northwest Coast Indians, 1774-1874. University of Washington Press ... The Bone River is a short river in the U.S. state of Washington. It is about 6 miles (9.7 km) long. The Bone River originates ... One of the first documented cases occurred at the mouth of the Bone River. A homesteader named James Swan witnessed the disease ... Most of the Bone River is marshy. It empties into an estuary and tidal marshland on Willapa Bay. U.S. Route 101 crosses the ...
In some cases, the cause of prion diseases is known. Ingestion of a copy of an abnormally folded, infectious PrP can induce a ... as well as Paget's Disease of Bone (Osteitis Deformans) which is associated with paramyxoviridae, especially RSV and Rubeola ( ... However, TSEs are more correctly classified as prion diseases. Prions are misfolded proteins that are "infectious" because they ... A slow virus disease is a disease that, after an extended period of latency, follows a slow, progressive course spanning months ...
... as a burn or wound Prevention and/or treatment of blood-borne pathogens Treatment of infectious diseases Management of bone and ...
... an extremely rare disease of bone. Benchmark changes in the understanding of medical science and the practice of medicine have ... lead the scientific advances behind the modern RotaTeq vaccine for infectious childhood diarrhea. In 2006, Drs. Kaplan and ... Core Principles Integrative Systems and Disease Technology and Practice of Medicine Required Clinical Clerkships Electives, ...
... and inflammatory bowel disease Malignancy - bone metastasis from lung, breast, prostate, thyroid, among others Infectious - ... Low back pain is not a specific disease but rather a complaint that may be caused by a large number of underlying problems of ... When a disc degenerates as a result of injury or disease, the makeup of a disc changes: blood vessels and nerves may grow into ... Low back pain (LBP) is a common disorder involving the muscles, nerves, and bones of the back. Pain can vary from a dull ...
... brittle bone disease, infectious proventriculitis, helicopter disease and pale bird syndrome). It consists of stunted growth in ... General hygiene and correct breeding conditions (especially correct brooding temperatures) may be efficient, but the disease ...
... or Paget's disease of bone) Osteitis fibrosa cystica (or Osteitis fibrosa, or Von Recklinghausen's disease of bone) Osteitis ... More specifically, it can refer to one of the following conditions: Osteomyelitis, or infectious osteitis, mainly bacterial ... pubis Radiation osteitis Osteitis condensans ilii Panosteitis, a long bone condition in large breed dogs In horses, pedal ...
... a Short-term fellowship in Clinical Immunology and Bone Marrow Transplantation in Paediatric Immunology and Infectious Diseases ... He initiated the Iranian Primary Immunodeficiency Diseases Registry (IPIDR) in 1999 under supervision of Professor Asghar ... "Primary Immunodeficiency Diseases", Immunology of Aging" and "Cancer Immunology" series. He has also won the 12th and 18th Razi ... Northern Supra Regional Bone Marrow Transplant Unit for SCID and Related Disorders, Newcastle, UK, awarded by the ESID ( ...
... paediatric-immunology-bone-marrow-transplantation-and-infectious-diseases.aspx http://www.renal.org/bapn/centres/lists/centres/ ... The Great North Children's Hospital is one of two units in the UK which perform bone marrow transplants for children who were ...
... "consumptive and infectious disease", "corpse attachment-illness" gǔzhēng 骨蒸 "bone-steaming disease", "consumptive disease with ... "cadaver vector disease", "consumptive and infectious disease", "corpse [evil] transmission" shīzhù 尸疰 "cadaver fixation disease ... Luo 2003: 4181) is for treating guzheng "bone-steaming disease": "To treat consumptive disease with general debility and hectic ... Luo 2003: 4171) specifies using a dead child's bone: "To treat bone fractures: Bone of infant, calcined, and muskmelon seed, ...
... and bone metastasis. It is also implicated in a variety of infectious inflammatory diseases, including chronic obstructive ... Cathepsin G has been reported to play an important role in a variety of diseases, including rheumatoid arthritis, coronary ... The American Review of Respiratory Disease. 144 (3 Pt 2): S48-51. doi:10.1164/ajrccm/144.3_pt_2.S48. PMID 1892327. Armao D, ... role in cardiovascular and cerebrovascular diseases". Arteriosclerosis, Thrombosis, and Vascular Biology. 21 (9): 1538-43. doi: ...
If a patient has a life-threatening infectious complication then bone marrow transplantation is no longer relevant for them. ... In Gunther's disease, porphyrins are accumulated in the teeth and bones and an increased amount are seen in the plasma, bone ... There are a multiple ways to treat Gunther's diseases, but one of the most crucial things that a person with this disease can ... though a lack of hemolysis in this disease is possible. Porphyrins additionally accumulate in the bone and teeth, resulting in ...
Infectious canine hepatitis is a sometimes fatal infectious disease of the liver. Canine herpesvirus is an infectious disease ... Hypertrophic osteopathy is a bone disease secondary to disease in the lungs. It is characterized by new bone formation on the ... Pseudorabies is an infectious disease that primarily affects swine, but can also cause a fatal disease in dogs with signs ... The disease in dogs can affect the eyes, brain, lungs, skin, or bones. Histoplasmosis* is a fungal disease caused by ...
However, no infectious virus has yet been isolated as a causative agent, and other evidence suggests an intrinsic ... and does not spread from bone to bone. Rarely, a bone affected by Paget's disease can transform into a malignant bone cancer. ... Ethel, SS; Roodman, GD (2008). "Paget's disease of bone". In Rosen. Primer on the metabolic bone diseases and disorders of ... Paget's Disease of Bone Overview - NIH Osteoporosis and Related Bone Diseases ~ National Resource Center. ...
Although this had 20 beds in the main ward, an eight-bed ward for bone disorders and an isolation ward for infectious diseases ...
The diseases specifically excluded from the list are high end diseases such as hip and knee replacement, bone morrow, cardiac ... infectious diseases,malaria, filaria, gastroenteritis, jaundice etc. To the extended RAS covers the treatments, it would no ... and liver transplantations, gamma-knife procedures in neuro surgery, assisted devices for cardiac failures etc; and diseases ...
MR1-Restricted Mucosal-Associated Invariant T Cells and Their Activation during Infectious Diseases. Frontiers in Immunology. ... bone marrow transplantation, and HIV-1 infection. Annual Review of Immunology. 2000, 18: 529-560. ISSN 0732-0582. PMID 10837068 ... Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease. Immunology. May 2016, 148 ( ... Modulation of autoimmune diseases by interleukin (IL)-17 producing regulatory T helper (Th17) cells. The Indian Journal of ...
An infectious bone disease is a bone disease primarily associated with an infection. An example is osteomyelitis. Root, Richard ... Clinical Infectious Diseases: A Practical Approach. Oxford University Press. p. 741. ISBN 9780195081039. Retrieved 5 December ...
Bone and Joint Infection: CD-Rom by Dennis L. Stevens from Waterstones today! Click and Collect from your local Waterstones or ... Buy Atlas of Infectious Diseases: Skin, Soft Tissue, ... Atlas of Infectious Diseases: Skin, Soft Tissue, Bone and Joint ... Science, Technology & Medicine > Medicine > Clinical & internal medicine > Infectious & contagious diseases Science, Technology ... Atlas of Infectious Diseases S. (CD-ROM). Dennis L. Stevens (editor) Sign in to write a review ...
Babesiosis is an infectious disease. June 23, 2012 admin A - Z Dogs, Dog Accessories, Dog Behaviour, Dog Care, Dog Training, ... Babesiosis is an infectious disease caused by a Protozoan (unicellular organism) called babesia intraeritrocitico (which is ... The clinical picture varies from percussion caps boxes (sharps) to mild, even limiting, so the disease is often go unnoticed, ... The treatment of choice today is to treat the parasitic disease with specific antiparasitics (Diminazeno Aceturato and ...
"Bone Diseases, Infectious" by people in this website by year, and whether "Bone Diseases, Infectious" was a major or minor ... "Bone Diseases, Infectious" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Bone Diseases, Infectious*Bone Diseases, Infectious. *Bone Disease, Infectious. *Disease, Infectious Bone ... Below are the most recent publications written about "Bone Diseases, Infectious" by people in Profiles. ...
Bone Diseases: Infectious Bone Diseases: Osteoarticular Tuberculosis - OCOSH Classification: Bone Diseases: Spinal Diseases: ... OCOSH Classification: Bone Diseases: Infectious Bone Diseases: Osteoarticular Tuberculosis - OCOSH Classification: ... OCOSH Classification: Bone Diseases: Infectious Bone Diseases: Osteoarticular Tuberculosis - OCOSH Classification: ... OCOSH Classification: Bone Diseases: Infectious Bone Diseases: Osteoarticular Tuberculosis - OCOSH Classification: ...
Non-infectious complications after bone marrow transplant: chronic graft-versus-host disease Celalettin Ustun ... Non-infectious complications after bone marrow transplant: chronic graft-versus-host disease. What every physician needs to ... Non-infectious complications after bone marrow transplant: chronic graft-versus-host disease*What every physician needs to know ... Close more info about Non-infectious complications after bone marrow transplant: chronic graft-versus-host disease ...
... patients with MS and other brain and central nervous system disorders and diseases. ... Non-infectious complications after bone marrow transplant: acute graft-versus-host disease. What every physician needs to know ... Non-infectious complications after bone marrow transplant: acute graft-versus-host disease. *By ... Non-infectious complications after bone marrow transplant: acute graft-versus-host disease ...
Bone And Joint Infections An Issue Of Infectious Disease Clinics Of North America 1st Edition Author Steven K Schmitt Dr ... Schmitt Has Put Together A Comprehensive Issue Devoted To Bone And Joint Infections ... First online issue of journal of bone and joint diseases online editorial journal of bone and joint diseases a new beginning ... Bone And Joint Infections An Issue Of Infectious Disease PDF, ePub eBook ...
... bone formation as well as bone resorption markers decreased significant. We postulate a protective effect on bone structure ... We measured the bone turnover markers in 96 HIV-infected patients: Bone specific alkaline phosphatase (BSAP), Pyridinoline (PYR ... Moreover, bone turnover markers are increased in patients on antiretroviral therapy and vitamin D deficiency is prevalent in ... 25OH-vitamin D and bone turn over markers were determinded 3 month later. 25 OH-vitamin D was corrected for circannual rythm y ...
... What every physician needs to know ... Non-infectious complications after bone marrow transplant: acute graft-versus-host disease. *By ... Non-infectious complications after bone marrow transplant: acute graft-versus-host disease ... What conditions can underlie non-infectious complications after bone marrow transplant: acute graft-versus-host disease: * ...
Published on behalf of Infectious Diseases Society of America Volume 33, issue 7, pages 947-953. Published in print October ... Bacteria remain an important cause of infection in bone marrow transplants. To examine shifts in the etiology and ... Bacteria remain an important cause of infection in bone marrow transplants. To examine shifts in the etiology and ...
Non-infectious complications after bone marrow transplant: acute graft-versus-host disease Celalettin Ustun ... Non-infectious complications after bone marrow transplant: acute graft-versus-host disease. What every physician needs to know ... Non-infectious complications after bone marrow transplant: acute graft-versus-host disease*What every physician needs to know ... What conditions can underlie non-infectious complications after bone marrow transplant: acute graft-versus-host disease:* ...
MEET THE INFECTIOUS DISEASE SPECIALISTS SEMINARS IN SECOND HALF OF 2019. October 16, 2019 ... Bone and joint infections have been reported to occur in 2 out of every 10,000 people. In children, the long bones of arms or ... Bone And Joint Infections. Definition. Bone and joint infections may be caused by bacteria, mycobacteria or fungi. They may ... A bone biopsy is the gold standard for diagnosing bone and joint infections. Tissue culture can reveal which micro-organism is ...
The Infectious Diseases Management Program (IDMP) at UCSF is an interprofessional and interhospital collaboration aimed at ... 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot ... Home » Hospitalized Adults: Bone & Joint Infections: Osteomyelitis. Hospitalized Adults: Bone & Joint Infections: Osteomyelitis ... Obtain bone biopsy to determine microbiologic cause prior to initiation of antimicrobial therapy if blood cultures are negative ...
Published on behalf of Infectious Diseases Society of America Volume 25, issue 6, pages 1295-1302. Published in print December ... Bone and joint infections are difficult to cure. The difficulty is related to the presence of bacteria adherent to foreign ... Bone and joint infections are difficult to cure. The difficulty is related to the presence of bacteria adherent to foreign ... Clinical trials are difficult to design because of the heterogeneity of the disease and the number of factors that could ...
The Infectious Diseases Management Program (IDMP) at UCSF is an interprofessional and interhospital collaboration aimed at ... Home » Hospitalized Adults: Bone & Joint Infections: Septic Arthritis. Hospitalized Adults: Bone & Joint Infections: Septic ...
Dhurve, S. A. (2013). BONE MARROW ABONRMALITIES IN HIV INFECTION. Mediterranean Journal of Hematology and Infectious Diseases, ... The Mediterranean Journal of Hematology and Infectious Diseases [eISSN 2035-3006]. is owned by the U.C.S.C. and it is published ... Bone marrow abnormalities occur in all stages of HIV infection. Present work was carried out to study the bone marrow ... Bone marrow was normocellular in 79.06% of non-AIDS and 79.68% of AIDS, hypocellular in 13.95%.Thrombocytopenia was seen in 4 ...
Humans have a high degree of resistance to foot-and-mouth disease, for example, while the cattle and sheep with which they may ... Rats are highly resistant to diphtheria, whereas unimmunized children readily contract the disease. What such resistance ... Every animal species possesses some natural resistance to disease. ... bone disease* In bone disease: Infectious diseases of bone. *Central African history* In Central Africa: Development of the ...
The Mediterranean Journal of Hematology and Infectious Diseases [eISSN 2035-3006]. is owned by the U.C.S.C. and it is published ... BONE MARROW BLASTS. Mediterranean Journal of Hematology and Infectious Diseases, 5(1), e2013032. https://doi.org/10.4084/mjhid. ... Patients with ≥ 20% ,30% bone marrow blast infiltration previously regarded as a transitional category between myelodisplasia ... TREATMENT OF ACUTE MYELOID LEUKEMIA WITH 20-30% BONE MARROW BLASTS DOI https://doi.org/10.4084/mjhid.2013.032 ...
The Mediterranean Journal of Hematology and Infectious Diseases [eISSN 2035-3006]. is owned by the U.C.S.C. and it is published ... Mediterranean Journal of Hematology and Infectious Diseases: Vol 6 No 1 (2014): Reviews, Articles, Case Reports and Letters ... Mediterranean Journal of Hematology and Infectious Diseases: Vol 7 (2015): Review Series, Original Articles, Case Reports ... Mediterranean Journal of Hematology and Infectious Diseases, 9(1), e2017030. https://doi.org/10.4084/mjhid.2017.030 ...
Bone Diseases, Infectious. Infection. Bone Diseases. Musculoskeletal Diseases. Spinal Diseases. Spondylarthropathies. ... Patients who have demyelinating disease or with a history of demyelinating disease ... Bath ankylosing spondylitis Disease Activity Index [ Time Frame: at week 24 ]. Secondary Outcome Measures : *Effectiveness ... Bath ankylosing spondylitis Disease Activity Index [ Time Frame: at week 12 ]. *Number of patients with adverse events [ Time ...
Bone Diseases, Infectious. Infection. Bone Diseases. Musculoskeletal Diseases. Spinal Diseases. Spondylarthropathies. ... IBD (Crohns disease or ulcerative colitis) and psoriaris are extra-articular manifestations of AS involving the intestinal ... Annual Incidence Rate of New-Onset or Flares of Inflammatory Bowel Disease (IBD) and Psoriasis in Participants Before Anti-TNF/ ... Percentage of Bath Ankylosing Spondylitis Disease Activity Index 50 (BASDAI 50) Responders Following Treatment With GLM [ Time ...
Bone Diseases, Infectious. Infection. Bone Diseases. Musculoskeletal Diseases. Spinal Diseases. Spondylarthropathies. ... BASMI 0 = indicates mild disease involvement, 1 = moderate disease, and 2 = severe disease involvement. The results for ... no disease activity]-100 [high disease activity]) for ,=3 of 4 domains; Patients Global Assessment of disease activity VAS; (0 ... no disease activity]-100 [high disease activity]) for ,=3 of 4 domains; Patients Global Assessment of disease activity VAS; (0 ...
Bone Diseases, Infectious. Infection. Bone Diseases. Musculoskeletal Diseases. Spinal Diseases. Spondylarthropathies. ... Joint Diseases. Arthritis. Etanercept. Anti-Inflammatory Agents, Non-Steroidal. Analgesics, Non-Narcotic. Analgesics. Sensory ... Use of disease modifying antirheumatic drugs (DMARDs) other than hydroxychloroquine, sulphasalazine, and methotrexate within 4 ...
Bone Diseases, Infectious. Infection. Bone Diseases. Musculoskeletal Diseases. Spinal Diseases. Spondylarthropathies. ... no disease activity, 10=high disease activity) for ,= 3 domains, and no worsening in remaining domain. ... no disease activity, 10=high disease activity) for ,= 3 domains, and no worsening in remaining domain. ... Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ,4 centimeter (cm), mean score on 10 cm VNS for discomfort, pain, ...
  • In 1983 Heffez and colleagues published a case report in which they suggested eight criteria for a definitive diagnosis of Gorham's disease: Positive biopsy with the presence of angiomatous tissue Absence of cellular atypia Minimal or no osteoblastic response or dystrophic calcifications Evidence of local bone progressive osseous resorption Non-expansile, non-ulcerative lesions No involvement of viscera Osteolytic radiographic pattern Negative hereditary, metabolic, neoplastic, immunologic, or infectious etiology. (wikipedia.org)
  • In 1999 Möller and colleagues concluded, "The Gorham-Stout syndrome may be, essentially, a monocentric bone disease with a focally increased bone resorption due to an increased number of paracrine - or autocrine - stimulated hyperactive osteoclasts. (wikipedia.org)
  • Moreover, bone turnover markers are increased in patients on antiretroviral therapy and vitamin D deficiency is prevalent in HIV-infected patients. (biomedcentral.com)
  • However, the influence of per oral cholecalciferol on bone metabolism in HIV infected patients is not well understood. (biomedcentral.com)
  • We measured the bone turnover markers in 96 HIV-infected patients: Bone specific alkaline phosphatase (BSAP), Pyridinoline (PYR), Desoxypyridinoline (DPD) and 25-OH vitamin D. If 25-OH vitamin D was below 75 nnol/L (87/96 patients), 300000 IU cholecalciferol was given per os. (biomedcentral.com)
  • In patients with low 25OH-vitamin D levels, we supplemented cholecalciferol and controlled bone turnover markers before and after supplementation. (biomedcentral.com)
  • Present work was carried out to study the bone marrow abnormalities in patients with HIV/AIDS. (mjhid.org)
  • Thus bone marrow study is imperative to methodically observe and follow clinical and laboratory aberration in such patients in order to improve our diagnostic and therapeutic skills pertinent to HIV/AIDS. (mjhid.org)
  • ASCA ( anti saccharomyces cerevisiae antibodies)are considered to be a serological marker for Crohn's disease and have been studied in patients with spondyloarthropathy with conflicting results. (clinicaltrials.gov)
  • By following the TNFalfa blocking treated patients the researchers want to identify better biomarkers for disease activity and disease progression. (clinicaltrials.gov)
  • The main objective is to describe the evolution under treatment of the FDG uptake in PET imaging in TB foci in patients cured from lymph node and bone TB. (clinicaltrials.gov)
  • Further, to look for improvement in endothelial function, and decrease in bone and cartilage destruction during treatment with the combination therapy of TNFalpha-inhibitor and methotrexate in RA and Psoriatic Arthritis (PSA) patients. (clinicaltrials.gov)
  • Last, examine the TNFalpha inhibitors influence on endothelial function and levels of bone and cartilage markers in patients with Ankylosing Spondylitis (AS). (clinicaltrials.gov)
  • Patients with RA and spondyloarthritis starting with either combination therapy of TNFalpha-inhibitor and methotrexate or methotrexate or TNFalpha-inhibitor alone, at Lillehammer Hospital for Rheumatic diseases.Decision about treatment modality will be based on conventional clinial judgement. (clinicaltrials.gov)
  • This study included 37 consecutive SCA patients who underwent bone marrow transplantation from human leukocyte antigen (HLA)-identical sibling donors between 2010 and 2015 following a myeloablative conditioning regimen. (mjhid.org)
  • Patients have inflammation of the joints of the spine, which may cause the bones of the spine to fuse, resulting in difficulty performing daily activities. (clinicaltrials.gov)
  • and 2) if CT can be used to determine how fast extra bone forms in the spine of these patients. (clinicaltrials.gov)
  • The goal of this pilot study is to test whether measurement of bone mineral density, bone volume, or bone mass at the annulus fibrosis of lumbar disc spaces by computed tomography (CT) can provide a reliable, valid, and sensitive measure of spinal fusion in patients with AS. (clinicaltrials.gov)
  • It supports patients and families with bone marrow failure. (seattlechildrens.org)
  • ViroPharma Incorporated (Nasdaq: VPHM) announced the publication of results of its previously described Phase 2 study showing that maribavir, when used as prophylaxis, reduced the rate of cytomegalovirus (CMV) reactivation and was well tolerated when compared to placebo in allogeneic stem cell , or bone marrow , transplant patients. (medicalnewstoday.com)
  • CMV is among the most important infectious causes of significant morbidity and mortality in transplant patients. (medicalnewstoday.com)
  • No patients taking maribavir at any dose developed CMV disease, compared to the placebo group in which three subjects (11 percent) developed the disease. (medicalnewstoday.com)
  • It is clear that maribavir has the potential to offer an important new and safer option for clinicians to prevent CMV disease in transplant patients. (medicalnewstoday.com)
  • While this dose-ranging study evaluated the safety and the ability of maribavir to prevent viral reactivation in bone marrow transplant patients, we are particularly encouraged by the possibility that maribavir may help reduce the rate of CMV disease and associated morbidity, something we are investigating in our current Phase 3 study," said Stephen Villano, M.D., vice president, clinical research and development at ViroPharma. (medicalnewstoday.com)
  • The panel consisted of 195 serum samples from well-characterized and classified patients under investigation for clinically suspected LB (n = 59) including patients with Lyme neuroborreliosis, Lyme arthritis, acrodermatitis chronica atrophicans, erythema migrans or other diseases (n = 112). (medworm.com)
  • We used human serum rigorously characterized to be sera from patients with acute- and convalescent-phase early Lyme disease, Lyme arthritis, and posttreatment Lyme disease syndrome, as well as the necessary controls (n = 241 samples), to select the best of 12 Borrelia burgdorferi proteins to improve our microfluidic assay (mChip-Ld). (medworm.com)
  • It occurs as a result of a wide range of diseases and/or physical conditions and may severely impair the quality of life for patients who suffer from it. (wikipedia.org)
  • Approximately 35% of patients with Paget's have symptoms related to the disease when they are first diagnosed. (wikipedia.org)
  • Kidney stones are somewhat more common in patients with Paget's disease. (wikipedia.org)
  • JC virus & BK virus only cause disease in immunocompromised patients Transmissible spongiform encephalopathies (TSEs), including Kuru and Creutzfeldt-Jakob disease of humans, scrapie of sheep, and bovine spongiform encephalopathy (BSE) of cattle, were previously classified as slow virus diseases as well. (wikipedia.org)
  • September 1993-The NIH Revitalization Act of 1993 (P.L. 103-43) directed NIAMS to establish "an information clearinghouse on osteoporosis and related bone disorders to facilitate and enhance knowledge and understanding on the part of health professionals, patients, and the public through the effective dissemination of information. (wikipedia.org)
  • Hematopoietic cells from NMDP donors or cord blood units are used to transplant patients with a variety of blood, bone marrow or immune system disorders. (wikipedia.org)
  • Large registries of unrelated donors are needed because only about 30% of patients with diseases treatable with hematopoietic cell transplantation can find a fully HLA matched donor among their family members. (wikipedia.org)
  • Patients presenting with this disease undergo antibiotic treatment and gammaglobulin transfusions. (wikipedia.org)
  • It was approved by the FDA in March 1991 under the trade name Leukine for acceleration of white blood cell recovery following autologous bone marrow transplantation in patients with non-Hodgkin's lymphoma, acute lymphocytic leukemia, or Hodgkin's disease. (wikipedia.org)
  • Microtransplantation(MST) is an advanced technology to treat malignant hematological diseases and tumors by infusing patients with granulocyte colony-stimulating factor (G-CSF) mobilized human leukocyte antigen (HLA)-mismatched allogeneic peripheral blood stem cells following a reduced-intensity chemotherapy or targeted therapy. (wikipedia.org)
  • Many of the signs and symptoms below are uncommon and most patients with the hereditary form of haemochromatosis do not show any overt signs of disease nor do they suffer premature morbidity. (wikipedia.org)
  • There is evidence suggesting that hereditary haemochromatosis patients affected with other liver ailments such as hepatitis or alcoholic liver disease suffer worse liver disease than those with either condition alone. (wikipedia.org)
  • However, Muelder & Nourou found that 10 out of 28 patients had relatives who had also had the disease, and cautioned against the dismissal of person-to-person transmission. (wikipedia.org)
  • Maribavir (originally named 1263W94) is an experimental oral antiviral drug candidate licensed by ViroPharma from GlaxoSmithKline in 2003 for the prevention and treatment of human cytomegalovirus (HCMV) disease in hematopoietic stem cell/bone marrow transplant patients. (wikipedia.org)
  • ViroPharma conducted a Phase III clinical study to evaluate the prophylactic use for the prevention of cytomegalovirus disease in recipients of allogeneic stem cell transplant patients. (wikipedia.org)
  • Although some experts recommend not treating typical CSD in immunocompetent patients with mild to moderate illness, treatment of all patients with antimicrobial agents (Grade 2B) is suggested due to the probability of disseminated disease. (wikipedia.org)
  • A common complaint among patients with cold agglutinin disease is painful fingers and toes with purplish discoloration associated with cold exposure. (wikipedia.org)
  • Cold agglutinins develop in more than 60% of patients with infectious mononucleosis, but hemolytic anemia is rare. (wikipedia.org)
  • Trisomy and translocation: Cytogenetic studies in patients with cold agglutinin disease have revealed the presence of trisomy 3 and trisomy 12. (wikipedia.org)
  • Transplantation: Cold agglutinin-mediated hemolytic anemia has been described in patients after living-donor liver transplantation treated with tacrolimus and after bone marrow transplantation with cyclosporine treatments. (wikipedia.org)
  • Beginning in the 1990s there were reports of elevated levels of a protein called interleukin-6 (IL-6) being detected in patients with the disease, leading some to suggest that increased levels of IL-6 and vascular endothelial growth factor (VEGF) may contribute to the chemical changes Gorham and others believed were the cause of this type of osteolysis. (wikipedia.org)
  • For example, many patients with chest pain carry a diagnosis of costochondritis (inflammation of the chest wall bones) or gastroesophageal reflux (regurgitation of stomach acid into the esophagus). (wikipedia.org)
  • PLCH patients, families, and caregivers are encouraged to join the NIH Rare Lung Diseases Consortium Contact Registry. (wikipedia.org)
  • Clinical Infectious Diseases: A Practical Approach. (wikipedia.org)
  • The clinical picture varies from percussion caps boxes (sharps) to mild, even limiting, so the disease is often go unnoticed, and on many occasions, even diagnosed. (thedogsbone.com)
  • Clinical trials are difficult to design because of the heterogeneity of the disease and the number of factors that could influence the therapeutic response. (oup.com)
  • Beginning with the history, genetics, pathophysiology and diagnostics of the disease, the authors subsequently present a detailed characterization of its clinical manifestation in the spine, peripheral joints, eyes, ears, visceral organs and respiratory tract, its pathological anatomy and histology, as well as differential diagnosis. (stanford.edu)
  • NIDDL provides clinical diagnostic laboratory services for active military and their families worldwide, specializing in less-common diseases not covered by the standard military treatment facilities of the Military Health System. (wikipedia.org)
  • Canine coronavirus is a gastrointestinal disease that is usually asymptomatic or with mild clinical signs. (wikipedia.org)
  • Disseminated disease occurs when the fungus has spread outside of the lungs and may include clinical signs such as lameness, pain, seizures, anterior uveitis, and localized swelling. (wikipedia.org)
  • According to a study performed in the Tucson and Phoenix area, 28% of dogs will test positive for exposure to the fungus by two years of age, but only 6% of the dogs will be ill with clinical disease. (wikipedia.org)
  • The clinical presentation of prion diseases will vary from patient to patient. (wikipedia.org)
  • Smallpox Disease and Its Clinical Management" (PDF). (wikipedia.org)
  • Clinical preventive services include screening for the existence of the disease or predisposition to its development, counseling and immunizations against infectious agents. (wikipedia.org)
  • 2006). Andrews' Diseases of the Skin: clinical Dermatology. (wikipedia.org)
  • A wide range of special care is provided: Aerosolized pentamidine Bone marrow aspiration Bronchoscopy Chemotherapy Colposcopy Diagnostic laboratory Endoscopy fibroscanGastroenterology/Hepatology Gynecology Hematology Infectious disease consultations Infusion and observation Neurology Nutrition Obstetrics Oncology Ophthalmology Pain Management Pharmaceutical care The CORE center performs some clinical studies into HIV/AIDS. (wikipedia.org)
  • As a field of general inquiry and research, pathology addresses four components of disease: cause, mechanisms of development (pathogenesis), structural alterations of cells (morphologic changes), and the consequences of changes (clinical manifestations). (wikipedia.org)
  • In common medical practice, general pathology is mostly concerned with analyzing known clinical abnormalities that are markers or precursors for both infectious and non-infectious disease and is conducted by experts in one of two major specialties, anatomical pathology and clinical pathology. (wikipedia.org)
  • The clinical presentation is dominated by severe sepsis and the formation of microabscesses, and a relationship between disease severity and the expression of the virulence factors Streptolysin S and SPEGdys has been inferred. (wikipedia.org)
  • Other responsibilities that Young has with the University of Minnesota include the Institutional Review Board, Co-chair of the Supportive Care/Infectious Disease/Toxicities Site Team for the Cancer Center, Physician Informatics Committee at the Medical Center, and Clinical Service Unit Board in the Department of Medicine. (wikipedia.org)
  • The first clinical description of immunity which arose from a specific disease causing organism is probably Kitab fi al-jadari wa-al-hasbah ('A Treatise on Smallpox and Measles', translated 1848) written by the Islamic physician Al-Razi in the 9th century. (wikipedia.org)
  • The Rare Diseases Clinical Research Network (RDCRN) is an initiative of the Office of Rare Diseases Research (ORDR). (wikipedia.org)
  • The RDCRN is designed to advance medical research on rare diseases by providing support for clinical studies and facilitating collaboration, study enrollment and data sharing. (wikipedia.org)
  • The following is a timeline of the Rare Diseases Clinical Research Network: As a result of the Rare Diseases Act of 2002, on February 27, 2003, the ORDR (in conjunction with the National Center for Research Resources (NCRR), the General Clinical Research Consortium (GCRC) Program, and other NIH Institutes) requested applications for a Rare Diseases Clinical Research Network. (wikipedia.org)
  • On November 3, 2003, the NIH established the Rare Diseases Clinical Research Network with a Data Technology Coordinating Center and the first Rare Disease Clinical Research Consortia (RDCRCs). (wikipedia.org)
  • The Rare Diseases Clinical Research Network consists of 22 Rare Diseases Clinical Research Centers (RDCRCs) and a Data Management and Coordinating Center (DMCC). (wikipedia.org)
  • The guideline recommends "for serious skin, bone, and soft tissue M fortuitum disease, a minimum of 4 months of therapy with at least two agents with in vitro activity against the clinical isolate is necessary to provide a high likelihood of cure. (wikipedia.org)
  • The more common clinical manifestations include: Fatigue Malaise Joint and bone pain Liver cirrhosis (with an increased risk of hepatocellular carcinoma) Liver disease is always preceded by evidence of liver dysfunction including elevated serum enzymes specific to the liver, clubbing of the fingers, leuconychia, asterixis, hepatomegaly, palmar erythema and spider naevi. (wikipedia.org)
  • The severity of clinical disease in the hereditary form varies considerably. (wikipedia.org)
  • few clinical trials have assessed outcomes in less-severe disease. (wikipedia.org)
  • The second stage is a fibrotic stage wherein scarring replaces damaged heart muscle tissue to cause a clinical presentation dominated by a poorly contracting heart and cardiac valve disease. (wikipedia.org)
  • Single multiplexed assays could replace the standard 2-tiered (STT) algorithm recommended for the laboratory diagnosis of Lyme disease if they perform with a specificity and a sensitivity superior or equal to those of the STT algorithm. (medworm.com)
  • Diagnosis is by either culturing the bacteria or detecting the bacterium's DNA in the blood, stool, or bone marrow. (wikipedia.org)
  • The institute investigates the prevention, diagnosis, causes, treatments and cures (PDCTC) for both common and rare diseases. (wikipedia.org)
  • Diagnosis is typically made by blood tests or bone marrow biopsy. (wikipedia.org)
  • They may spread through the bloodstream into the bone and joints (hematogenous spread) or via entry of the micro-organisms from penetrating injuries or from nearby infected tissue or contaminated open wounds (contiguous spread). (idspecialists.sg)
  • Fibromyalgia is not a form of arthritis (a disease of the joints), but rather a muscle disorder. (medicinenet.com)
  • apatite deposition disease a connective tissue disorder marked by deposition of hydroxyapatite crystals in one or more joints or bursae. (thefreedictionary.com)
  • These structural changes cause the bone to weaken, which may result in deformity, pain, fracture, or arthritis of associated joints. (wikipedia.org)
  • Bones, joints, and muscles normal. (wikipedia.org)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • Saving Lives, Protecting People Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • http://www.who.int/mediacentre/factsheets/fs100/en/ Centers for Disease Control and Prevention, (16 August 2010) "Eastern Equine Encephalitis. (wikipedia.org)
  • Centers for Disease Control and Prevention (1998), Botulism in the United States 1899-1996: Handbook for Epidemiologists, Clinicians, and Laboratory Workers, Atlanta, Georgia. (wikipedia.org)
  • Centers for Disease Control and Prevention, (7 February 2011) "Diphtheria. (wikipedia.org)
  • citation needed] The virus was discovered in 2014 by Olga Kosoy, Amy Lambert and colleagues from the Centers for Disease Control and Prevention (CDC) in Fort Collins, Colorado, in a sample of blood from the case patient. (wikipedia.org)
  • alpha chain disease heavy chain disease characterized by plasma cell infiltration of the lamina propria of the small intestine resulting in malabsorption with diarrhea, abdominal pain, and weight loss, possibly accompanied by pulmonary involvement. (thefreedictionary.com)
  • Bone tumors are composed of a conglomeration of cell types including cancer and immune system cells. (wikipedia.org)
  • Rosai-Dorfman disease itself was classified into "Familial," "Classical (nodal)," "Extranodal," "Neoplasia-associated," and "Immune disease-associated" subtypes. (wikipedia.org)
  • Findings from these experiments can be used to manipulate the immune system and develop drugs to combat immunological diseases. (wikipedia.org)
  • Other causes or associations of disease are: a compromised immune system, environmental toxins, radiation exposure, diet and lifestyle choices, stress, and genetics. (wikipedia.org)
  • The exact cause of IOI is unknown, but infectious and immune-mediated mechanisms have been proposed. (wikipedia.org)
  • White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. (wikipedia.org)
  • https://www.theguardian.com/commentisfree/2019/jul/19/lyme-disease-pentagon-tick. (medworm.com)
  • Just over 20 years ago, a Lyme disease vaccine called LYMErix was approved for sale in the United States. (medworm.com)
  • Borrelia burgdorferi glycosaminoglycan-binding proteins: a potential target for new therapeutics against Lyme disease. (medworm.com)
  • Authors: Lin YP, Li L, Zhang F, Linhardt RJ Abstract The spirochete bacterium Borrelia burgdorferisensu lato is the causative agent of Lyme disease, the most common vector-borne disease in Europe and the United States. (medworm.com)
  • Thus, there is a need to investigate alternative therapeutics against Lyme disease. (medworm.com)
  • Such information should motivate the discovery and development of novel GAG analogues as new therapeutics for Lyme disease. (medworm.com)
  • AbstractBorreliosis (Lyme disease) is a spirochetal disease caused by the species complex ofBorrelia burgdorferi transmitted byIxodes spp. (medworm.com)
  • What 's really behind the spread of Lyme disease? (medworm.com)
  • Lyme disease* is a disease caused by Borrelia burgdorferi, a spirochaete, and spread by ticks of the genus Ixodes. (wikipedia.org)
  • The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) is one of the institutes and centers that make up the National Institutes of Health, an agency of the United States Department of Health and Human Services (HHS). (wikipedia.org)
  • January 1975-The National Arthritis Act (P.L. 93-640) established the National Commission on Arthritis and Related Musculoskeletal Diseases to study the problem of arthritis and to develop an arthritis plan. (wikipedia.org)
  • April 1976-After a year of study and public hearings, the commission issued a comprehensivtre plan aimed at diminishing the physical, economic and psychosocial effects of arthritis and musculoskeletal diseases. (wikipedia.org)
  • 1982-HHS conferred bureau status on the Institute, resulting in creation of the Division of Arthritis, Musculoskeletal and Skin Diseases and the appointment of a Division Director. (wikipedia.org)
  • November 1985-The Health Research Extension Act of 1985, P.L. 99-158, established the National Institute of Arthritis and Musculoskeletal and Skin Diseases to increase research emphasis. (wikipedia.org)
  • The legislation provided for the development of a plan for a national arthritis and musculoskeletal diseases program and established two interagency coordinating committees, one on arthritis and musculoskeletal diseases and one on skin diseases. (wikipedia.org)
  • October 2000-The Children's Health Act of 2000 (P.L. 106-310) directed NIAMS to expand and intensify research programs on juvenile arthritis and related conditions, in coordination with other NIH Institutes and the Arthritis and Musculoskeletal Diseases Interagency Coordinating Committee. (wikipedia.org)
  • Tests had previously ruled out a wide range of tick-borne diseases including anaplasmosis, babesiosis, ehrlichiosis, Q fever, Rocky Mountain spotted fever and tularemia. (wikipedia.org)
  • These organizations (mostly hospitals and blood banks) have established relationships with the NMDP and work together to arrange the collection and transfer of donated bone marrow or PBSCs, or the transfer of previously collected cord blood. (wikipedia.org)
  • October 1976-The Arthritis, Diabetes, and Digestive Diseases Amendments of 1976 (P.L. 94-562) established the National Arthritis Advisory Board to review and evaluate the implementation of the Arthritis Plan, prepared in response to the National Arthritis Act (P.L. 93-640). (wikipedia.org)
  • December 1980-P.L. 96-538 changed the name of the Institute to the National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases. (wikipedia.org)
  • Diabetes, for example, is the leading cause of new cases of blindness in those aged 20-74, with ocular manifestations such as diabetic retinopathy and macular edema affecting up to 80% of those who have had the disease for 15 years or more[citation needed]. (wikipedia.org)