Diseases of BONES.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Bone loss due to osteoclastic activity.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.
Tumors or cancer located in bone tissue or specific BONES.
Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Dissolution of bone that particularly involves the removal or loss of calcium.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
Breaks in bones.
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.
Syndromes of bone destruction where the cause is not obvious such as neoplasia, infection, or trauma. The destruction follows various patterns: massive (Gorham disease), multicentric (HAJDU-CHENEY SYNDROME), or carpal/tarsal.
The process of bone formation. Histogenesis of bone including ossification.
A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.
Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
The largest of three bones that make up each half of the pelvic girdle.
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.
A VITAMIN D that can be regarded as a reduction product of vitamin D2.
Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)
The grafting of bone from a donor site to a recipient site.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.
Diseases of the bones related to hyperfunction or hypofunction of the endocrine glands.
A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Abnormally high level of calcium in the blood.
Stable strontium atoms that have the same atomic number as the element strontium, but differ in the atomic weight. Sr-84, 86, 87, and 88 are the stable strontium isotopes.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
Death of a bone or part of a bone, either atraumatic or posttraumatic.
A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.
A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.
A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).
Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.
A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.
A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher.
An abnormal hardening or increased density of bone tissue.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.
Bone diseases caused by pathogenic microorganisms.
COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.
Inorganic compounds that contain TECHNETIUM as an integral part of the molecule. Technetium 99m (m=metastable) is an isotope of technetium that has a half-life of about 6 hours. Technetium 99, which has a half-life of 210,000 years, is a decay product of technetium 99m.
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.
Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
A coronary vasodilator agent.
A circular structural unit of bone tissue. It consists of a central hole, the Haversian canal through which blood vessels run, surrounded by concentric rings, called lamellae.
Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.
A condition of an abnormally low level of PHOSPHATES in the blood.
Inorganic salts of phosphoric acid.
Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
AMINO ACIDS composed of GLYCINE substituted at the nitrogen rather than the usual carbon position, resulting in the loss of HYDROGEN BONDING donors. Polymers of these compounds are called PEPTOIDS.
A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.
Formation of stones in the KIDNEY.
Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia.
The spinal or vertebral column.
Excision of one or more of the parathyroid glands.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The bone that forms the frontal aspect of the skull. Its flat part forms the forehead, articulating inferiorly with the NASAL BONE and the CHEEK BONE on each side of the face.
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.
A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.
Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.
Elements of limited time intervals, contributing to particular results or situations.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.
Local surroundings with which cells interact by processing various chemical and physical signals, and by contributing their own effects to this environment.
A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.
Pathologic deposition of calcium salts in tissues.
Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.
A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.
A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.
The bones of the free part of the lower extremity in humans and of any of the four extremities in animals. It includes the FEMUR; PATELLA; TIBIA; and FIBULA.
A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
Removal of bone marrow and evaluation of its histologic picture.
Fractures of the femur.
The five cylindrical bones of the METACARPUS, articulating with the CARPAL BONES proximally and the PHALANGES OF FINGERS distally.
Inorganic or organic compounds that contain the basic structure RB(OH)2.
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.
Tumors or cancer of the human BREAST.
The five long bones of the METATARSUS, articulating with the TARSAL BONES proximally and the PHALANGES OF TOES distally.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
The seven bones which form the tarsus - namely, CALCANEUS; TALUS; cuboid, navicular, and the internal, middle, and external cuneiforms.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
CCR receptors with specificity for a broad variety of CC CHEMOKINES. They are expressed at high levels in MONOCYTES; tissue MACROPHAGES; NEUTROPHILS; and EOSINOPHILS.
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.
Cholecalciferols substituted with two hydroxy groups in any position.
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.
The TARSAL BONES; METATARSAL BONES; and PHALANGES OF TOES. The tarsal bones consists of seven bones: CALCANEUS; TALUS; cuboid; navicular; internal; middle; and external cuneiform bones. The five metatarsal bones are numbered one through five, running medial to lateral. There are 14 phalanges in each foot, the great toe has two while the other toes have three each.
Tumors or cancer of the PROSTATE.
LDL-receptor related protein that combines with FRIZZLED RECEPTORS at the cell surface to form receptors that bind WNT PROTEINS. The protein plays an important role in the WNT SIGNALING PATHWAY in OSTEOBLASTS and during EMBRYONIC DEVELOPMENT.
An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
The outer shorter of the two bones of the FOREARM, lying parallel to the ULNA and partially revolving around it.
A surgical specialty which utilizes medical, surgical, and physical methods to treat and correct deformities, diseases, and injuries to the skeletal system, its articulations, and associated structures.
A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.
Fibrous blood-filled cyst in the bone. Although benign it can be destructive causing deformity and fractures.
Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
The giving of drugs, chemicals, or other substances by mouth.
The surgical removal of one or both ovaries.
A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
A bone morphogenetic protein that is a potent inducer of BONE formation. It plays additional roles in regulating CELL DIFFERENTIATION of non-osteoblastic cell types and epithelial-mesenchymal interactions.
The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
Progenitor cells from which all blood cells derive.
Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Implantable fracture fixation devices attached to bone fragments with screws to bridge the fracture gap and shield the fracture site from stress as bone heals. (UMDNS, 1999)
The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).
Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.
A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).

Tracking adhesion factors in Staphylococcus caprae strains responsible for human bone infections following implantation of orthopaedic material. (1/59)

Ten Staphylococcus caprae strains isolated from four patients and responsible for bone infections following implantation of orthopaedic material were compared to four S. caprae strains collected from milk samples of healthy goats. The following characteristics were investigated: Smal patterns, hybridization patterns with pBA2 (ribotypes), slime production, adhesion to matrix proteins (fibrinogen, fibronectin, collagen) and the staphylococcal adhesion genes (fnbA, clfA, cna, atlE, ica, fbe). None of the characteristics enabled us to distinguish the human strains from the goat strains. Slime was occasionally produced by S. caprae strains but all of them carried nucleotide sequences hybridizing at low stringency with the following genes: atlE encoding a S. epidermidis autolysin binding vitronectin and responsible for the primary adhesion to polystyrene, ica operon involved in the biosynthesis of a S. epidermidis extracellular polysaccharide, and the part of clfA encoding the serine-aspartate repeated region of a S. aureus cell-wall fibrinogen-binding protein.  (+info)

Aspergillosis in children with cancer: A 34-year experience. (2/59)

A retrospective review of medical records, microbiology and pathology laboratory records, and nosocomial infection surveillance data was undertaken to describe the experience with culture-documented aspergillus infection in pediatric cancer patients at our facility. Sixty-six patients were identified from a 34-year period. The most common underlying diagnosis was leukemia. Risk factors included neutropenia, immunosuppression, and prior antibiotic therapy. On the basis of clinical presentation, 23 patients were believed to have disseminated disease and 43 to have localized disease. The lung was the most frequently affected organ. Despite aggressive medical and surgical management, overall mortality was 85% within the first year after diagnosis. Patients who presented with disease in sites other than the lungs fared better than patients with initial pulmonary involvement (P=.0014). Aspergillosis continues to be associated with poor outcome. Development of improved medical and adjuvant therapies, including surgery, is warranted.  (+info)

Tackling osseous hydatidosis using orthopaedic oncology techniques. (3/59)

Hydatid disease of bone is rare; success in management is difficult as recurrence is common. We report the successful use of orthopaedic oncological techniques and technology in treating a patient with hydatid disease affecting his humerus.  (+info)

Scedosporium apiospermum in chronic granulomatous disease treated with an HLA matched bone marrow transplant. (4/59)

A patient with chronic granulomatous disease who was being treated with steroids was diagnosed with a soft tissue Scedosporium apiospermum infection. Despite extensive treatment with antifungals progression to involve solid tissue (bone) occurred. Treatment required an HLA matched bone marrow transplant, which led to complete clearance of the fungal infection, although the patient subsequently died.  (+info)

Mechanism of accumulation of 99mTc-sulesomab in inflammation. (5/59)

99mTc-Sulesomab, the Fab fragment of anti-NCA-90, is used as an in vivo granulocyte labeling agent for imaging inflammation. It is not clear to what extent it targets cells that have already migrated into the interstitial space of an inflammatory lesion as opposed to circulating cells. The contribution to signal of radioprotein diffusion in the setting of increased vascular permeability is also poorly documented. METHODS: We compared the local kinetics of (99m)Tc-sulesomab and (99m)Tc-labeled human serum albumin (HSA), which have similar molecular sizes, in 7 patients with orthopedic infection proven by clearly positive (111)In-leukocyte scintigraphy. (99m)Tc-Sulesomab and (99m)Tc-HSA were administered in sequence separated by an interval of 2-6 d. Images were obtained 1, 3, 4, and 6 h after injection, and multiple venous blood samples were obtained for blood clearance measurement. Patlak-Rutland (P-R) analysis was performed to measure lesion and control tissue protein clearance. Target-to-background tissue (T/Bkg) ratios were calculated for each radioprotein and compared with the T/Bkg ratio for (111)In-leukocytes. (99m)Tc-Sulesomab binding to granulocytes was measured in vitro and ex vivo and to primed and activated granulocytes in vitro. RESULTS: After intravenous injection, <5% of the circulating radioactivity was cell bound with both radioproteins so that the P-R curves could therefore be assumed to represent extravascular uptake of free protein. The blood clearance (mean +/- SD) of sulesomab was 23.4 +/- 11.7 mL/min, approximately 5 times greater than that of HSA, for which it was 4.8 +/- 3.1 mL/min. Likewise, clearance into the lesion of sulesomab was consistently higher than that of HSA, on average about 3 times as high. Nevertheless, the T/Bkg ratios for sulesomab and HSA were similar, except at 6 h when that of HSA (2.14 +/- 0.6) was higher than that of sulesomab (1.93 +/- 0.5; P approximately 0.01). Both values were considerably less than the T/Bkg ratio on the (111)In-leukocyte images, which, at 22 h, was 12.3 +/- 5.3. Moderate clearance of sulesomab, but not HSA, was seen in the control tissue. Granulocytes bound significantly more (99m)Tc-sulesomab in vitro when primed or activated. CONCLUSION: (a) Sulesomab does not localize in inflammation as a result of binding to circulating granulocytes; (b) sulesomab is cleared into inflammation nonspecifically via increased vascular permeability; nevertheless, it may be cleared after local binding to primed granulocytes or bind to activated, migrated extravascular granulocytes; and (c) HSA produces a similar or higher T/Bkg ratio than sulesomab because sulesomab is cleared into normal tissues and because image positivity in inflammation is significantly dependent on local blood-pool expansion.  (+info)

Bone scintigraphy as an adjunct for the diagnosis of oral diseases. (6/59)

Bone scintigraphy is a very sensitive method for the detection of osteoblastic activity of the skeleton. The technique consists of imaging the uptake of bone-seeking radiopharmaceuticals, particularly technetium-99m labeled diphosphonates, in the mineral component of bone, which consists of hydroxyapatite crystals and calcium phosphate, as well as in the organic matrix such as collagen fibers. Plain radiographs, computed tomography, and magnetic resonance imaging are classified as structural imaging modalities, whereas bone scintigraphy is a functional method. In many cases, radionuclide imaging techniques are the only means by which early physiologic changes that are a direct result of biochemical alteration may be assessed, before significant bone mineral changes can be detected by other means. Since many oral diseases may cause metabolic changes in the oromaxillofacial complex, it would be of great value to use bone scintigraphy to evaluate more completely some conditions involving the bones in the region to formulate more appropriate treatment plans. Based upon the current literature, the authors discuss the possible applications of bone scintigraphy as a diagnostic and treatment planning adjunct for oral diseases. Bone scintigraphy has proven particularly useful in the study of malignant lesions and in the evaluation of vascularized bone grafts used for maxillofacial reconstructions.  (+info)

Cost-minimization analysis and audit of antibiotic management of bone and joint infections with ambulatory teicoplanin, in-patient care or outpatient oral linezolid therapy. (7/59)

Bone and joint infections are significant causes of morbidity, mortality and healthcare costs. The cost of treatment for such infections is driven primarily by the length of hospital stay. Many of these infections will require treatment with prolonged periods of parenteral antibiotic therapy. Clinicians and healthcare managers are being attracted increasingly by administering treatment in the ambulatory setting as this offers clinical, economic and quality of life advantages from both the hospital's and patient's perspective. Our retrospective audit of managing 55 treatment episodes of bone and joint infections with teicoplanin delivered in the outpatient or home setting revealed that the mean cost of care per episode of infection was less with treatment in the ambulatory setting ( pound 1749.15) compared with the in-patient setting ( pound 11 400) or compared with the hypothetical situation of treatment with oral linezolid in the home setting ( pound 2546). Teicoplanin therapeutic drug monitoring appears to be valuable in establishing optimal serum levels, which appear to correlate with good clinical outcomes. The potential for alternative day or thrice weekly dosing with teicoplanin may offer further cost advantages whilst maintaining equivalent clinical effectiveness.  (+info)

Synthesis and characterization of hydroxyapatite-ciprofloxacin delivery systems by precipitation and spray drying technique. (8/59)

This investigation synthesized and characterized hydroxyapatite (HAP) microspheres, agglomerated microspheres, and implants containing ciprofloxacin. This delivery system is to be used as an implantable drug delivery system for the treatment of bone infections. The HAP microspheres were made by chemical precipitation followed by a spray-drying technique. Agglomerated microspheres were prepared by a wet granulation process using a granulator. Implants were prepared by direct compression of the granules on a Carver press. Ciprofloxacin was analyzed by high-performance liquid chromatography. Characterization of the HAP microspheres include particle size, size distribution, physical state of the drug in the microsphere, and microstructure of the drug delivery system before and after in vitro release. The particle size, porosity, and morphology of the microspheres were dependent on viscosity and concentration of the slurry as well as the atomization pressure used during spray drying. Even at the highest drug load (2% wt/wt), the drug was present in a noncrystalline state. The drug release from the agglomerated microspheres was quick and almost complete within 1 hour. However, compressing the same amount of agglomerated microspheres into an implant greatly reduced the rate of ciprofloxacin release. Only 12% (wt/wt) of the drug was released from the implant within 1 hour. The in vitro release of ciprofloxacin from these implants follows a diffusion-controlled mechanism. This method provides a unique way of producing various shapes and drug loads of HAP microspheres that can be easily manufactured on a commercial scale.  (+info)

Staphylococcus caprae is a Gram-positive, coccus bacteria and a member of the genus Staphylococcus. S. caprae is coagulase-negative. It was originally isolated from goats (caprae means of a goat), but members of this species have also been isolated from human samples. S. caprae occurs as a commensal on human skin, but has also been implicated in infections of the bloodstream, urinary tract, bones, and joints. Because S. caprae is difficult to identify definitively in the laboratory, according to a study in 2014, the incidence of S. caprae in humans in under-reported. It is a coagulase-negative, DNase-positive member of the genus Staphylococcus. Usually it is associated with goats. Since 1991, a few laboratories reported that they had isolated the organism from human clinical specimens. It is now an emerging microorganism in joint and bone infections in humans. Staphylococcus was first described in 1983 by Devisee et al. based on a strain isolated from some goat milk. It can sometimes cause ...
Harrington MD. Initial oral antibiotic therapy was noninferior to IV therapy for treatment failure in orthopedic infection at 1 y. Ann Intern Med. 2019;170:JC58. doi: 10.7326/ACPJ201905210-058. Download citation file:. ...
A 14-year-old boy presented to another hospital with a clinical picture of septic arthritis. After aspiration of purulent material from the joint, empiric antibiotic treatment was initiated and an arthrotomy was performed. Antibiotic treatment was then modified to nafcillin according to microbiological sensitivity results of the isolated Staphylococcus aureus as determined by minimal inhibitory concentration testing. One week later purulent drainage recurred and open drainage had to be repeated; an abscess anterior to the joint was noted. Once again the infection failed to resolve, and the patient was transferred to our institution where a third arthrotomy had to be performed. The organism isolated at the first aspiration was reexamined and found to have a minimal bactericidal concentration to minimal inhibitory concentration ratio of 32, implying a tolerant organism. The antibiotic treatment was modified to an antibiotic not subject to the tolerance phenomenon, and the infection resolved without
by Stephen Kates (Author), Olivier Borens (Author) Written by 63 world renowned experts, Principles of Orthopaedic infection management takes you to the spectrum of Orthopaedic Infection from Osteomyelitis, Septic arthritis, Infection following Intramedullary nailing/plating, Periprosthetic infection. There is special emphasis on the importance of Biofilm, special methods of bacterial cultures, and diagnosis of bacterial infection. […]. ...
by Stephen Kates (Author), Olivier Borens (Author) Written by 63 world renowned experts, Principles of Orthopaedic infection management takes you to the spectrum of Orthopaedic Infection from Osteomyelitis, Septic arthritis, Infection following Intramedullary nailing/plating, Periprosthetic infection. There is special emphasis on the importance of Biofilm, special methods of bacterial cultures, and diagnosis of bacterial infection. […]. ...
BOZEMAN, MT, and VANCOUVER, BC--(Marketwired - June 16, 2016) - Microbion Corporation (Microbion) of Bozeman, MT, USA and Microbion Pharma Corp. of Vancouver, BC, Canada, specializing in the treatment of hard to treat and antibiotic-resistant infections, today announced that James Krieg, M.D., of Thomas Jefferson Hospital in Philadelphia, Pennsylvania, has...
Coloured X-ray (front view) of the bones of the knee of a 39 year old patient, showing the presence of bone infection (dark areas) with atypical bacteria (atypical mycobacteriosis). The bacteria were Staphylococcus aureus (37%), pneumococci (13%) and Mycobacterium tuberculosis (10%). The infection occurred after orthopaedic surgery. - Stock Image C004/1405
Reviews and ratings for claforan when used in the treatment of bone infection. Share your experience with this medication by writing a review.
Dr. Kates performs joint replacement and arthritis surgery of the hip, knee, and shoulder primarily for the middle aged and elderly patients. Additionally he cares for the elderly with fragility fractures and orthopaedic infections. His practice is focused on providing excellent care to our aging population. He is a board-certified orthopaedic surgeon, Director of the Geriatric Fracture Center, and a member of the Evarts Joint Center at Highland Hospital. He is also Professor of Orthopaedics and Rehabilitation, and Chief of the Oncology, Metabolic Bone and Geriatric Division at the University of Rochester Medical Center ...
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More severe cases of osteomyelitis require more extreme treatment. They can require surgery to scrape the infection from the bone or remove any dead parts of the bone. Your doctor may recommend a skin graft to remove infected skin and replace it with healthy skin from another part of the body. Bone grafts are another option. In a worst-case scenario, doctors may need to amputate the affected limb.. Patients should be prepared for follow-up appointments with their doctor, who might order more lab work and imaging scans to check their progress.. If your immune system is compromised, a bone infection can recur. Its important to take every measure to prevent osteomyelitis in the first place. There are several precautions you can take:. ...
The Houston Zoos newest addition, a giraffe calf named Yao Ming, is battling a life-threatening bone infection, zoo officials said. The Massai calf, born on Feb. 25, underwent arthroscopic surgery this week to remove infected bone from his right shoulder, said zoo director Rick Barongi. When the limp gradually became worse, however, zoo veterinarians X-rayed the leg and found no evidence of bone damage, officials said. Winchell determined that Yao had developed a bone infection in his right shoulder and began an aggressive treatment regimen that included flushing the joint, removing the damaged tissue and infected bone, and administering stronger antibiotics.
The invention provides a biocompatible material derived from keratin that is useful for many aspects of medical treatment of bone. The keratin material is preferably S-sulfonated and enriched in intermediate filament proteins of high molecular weight. The keratin material may be porous for use as a bone replacement and augmentation product but also provided is the use of dense keratin materials in bone treatment for use as an internal fixation appliance in the treatment of bone fractures and bone regeneration, and a method for preparing the keratin material for use in the preservation, restoration and development of form and function of bone.
Description: taphylococcus aureus (S. aureus) is an independent risk factor for orthopaedic surgical site infection (SSI). To determine whether a preoperative decolonization protocol reduces S. aureus SSIs, we conducted a prospective observational study of patients undergoing elective total joint arthroplasty (TJA) at our institution, with two control groups. The concurrent control group comprised patients of surgeons who did not participate in the intervention study. The preintervention control group comprised patients of participating surgeons who had undergone elective TJA during the year before the study. Patients in the intervention group were screened preoperatively for S. aureus by nasal swab cultures. S. aureus carriers were decolonized with mupirocin ointment to the nares twice daily and chlorhexidine bath once daily for 5 days before surgery. All 164 of 636 participants (26%) who tested positive completed the decolonization protocol without adverse events and had no postoperative S. ...
Bone Infection (Osteomyelitis) Basics So youve been told you have osteomyelitis, or you might have osteomyelitis. Thats a five dollar word for bone infection. Read on to get a few facts about this condition, and where it may lead you in the short term. Staph Aureus is the most common causative organism Bone infection means that a bacteria has gotten through the … [Read more...] about 5 Facts About Osteomyelitis (Bone Infection) ...
Particles of a variety of orthopaedic materials have been implicated with bone resorption both in vivo and in vitro. The polymer investigated in this study is poly(L-lactide), a bioresorbable material which has been used in orthopaedics to manufacture screws and pins for fracture fixation. Poly(L-lactide) implants degrade and release particulate debris prior to their resorption. So far, the particles generated during the degradation of poly(L-lactide) implants have not been implicated with bone resorption in human clinical trials however, osteolysis in the vicinity of degrading resorbable implants made of a similar material known as poly(glycolide) has been observed radiographically. The biocompatibility of poly(L-lactide) particles was investigated using both in vitro and in vivo techniques in this project and the findings can be summarised as follows: 1. Exposure of fibroblasts to poly(L-lactide) particulates caused an increase in prostaglandin E2 (PGE2) release from intact viable cells ...
Part of the Manchester Tissue Regeneration & Stem Cell Network Seminar Series.. How mesenchymal stem cell fate is controlled by the cell/material interface is becoming better understood in terms of material chemistry, mechanical properties and topography. We have focused on the use of nanoscale topography to target MSC differentiation to bone with a view to design of new orthopaedic materials. However, we have also studied MSC growth without differentiation using nanotopography. This is important if we wish to expand large numbers of high quality autologous MSCs for clinical use. We have shown that control of adhesion and cytoskeletal tension is important in regulating growth through mitogen activated protein kinases and subtle alterations in cell cycle. From these observation we have gone on to develop dynamic growth platforms that allow first MSC expansion and then targeted differentiation on user demand and also to start to bioengineer 3D bioengineered MSC niches that could be useful in e.g. ...
Osteomyelitis is an infection of a bone. Symptoms include pain and tenderness over the affected area of bone, and feeling unwell. It is a serious infection...
Osteomyelitis (an infection of the bone) can be caused by a variety of microbial agents (bacteria, fungus), the most common of which is staphylococcus aureus.. This serious infection can occur from a number of sources:. ...
A great deal of research is ongoing in the area of tissue engineering (TE) for bone regeneration. A possible improvement in restoring damaged tissues involves the loading of drugs such as proteins, genes, growth factors, antibiotics, and anti-inflammatory drugs into scaffolds for tissue regeneration. This mini-review is focused on the combination of the local delivery of antibiotic agents with bone regenerative therapy for the treatment of a severe bone infection such as osteomyelitis. The review includes a brief explanation of scaffolds for bone regeneration including scaffolds characteristics and types, a focus on severe bone infections (especially osteomyelitis and its treatment), and a literature review of local antibiotic delivery by the combination of scaffolds and drug-delivery systems ...
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Osteomyelitis is an infectious process in bone that occasionally leads to bone destruction. Traditionally, the surgical treatment procedure is performed in combination with systemic and local antibiot
Sepsis represents uncontrolled inflammation due to an infection. Cold-inducible RNA-binding protein (CIRP) is a stress-induced damage-associated molecular pattern (DAMP). A subset of neutrophils expressing ICAM-1+ neutrophils was previously shown to produce high levels of reactive oxygen species. The role of CIRP for the development and function of ICAM-1+ neutrophils during sepsis is unknown. We hypothesize that CIRP induces ICAM-1 expression in neutrophils causing injury to the lungs during sepsis. Using a mouse model of cecal ligation and puncture (CLP)-induced sepsis, we found increased expression of CIRP and higher frequencies and numbers of ICAM-1+ neutrophils in the lungs ...
Osteomyelitis is an inflammation or swelling of bone tissue. Its most often caused by an infection. Bone infection may occur for many reasons and can affect children or adults.
Osteomyelitis is a bone infection caused by germs entering the bodys tissues through an open wound. The easiest way to prevent it is to practice good hygiene.
Osteomyelitis is a bone infection that can happen when germs enter an open wound. The easiest way to prevent it is to keep skin clean.
Infections of Bones and Joints; Pediatrics; Pediatric Infectious Diseases; Acute & Chronic Diseases and Conditions in Pediatric Patients; Bladder Infection; Bone Infection ...
Bladder infection? Go to the doctor for a course of antibiotics. We are also prescribed antibiotics for lung and bone infections, and blood poisoning. Dutch pharmacists provide around 7.2 million courses of antibiotics per year.
We need at lot of prayer for my husband. Hes had 4 of CT Scan and One MRI. He has a bone infection in his lower back and a couple of abscess areas that are really infected. We are being sent up to the University of Washington this week to see if they will do surgery and clean up the areas. Hes had crohns for 28 years hes had 2 surgery and only has some of his small bowel left not much. He is going to one of the best surgeon at UW. I was thinking the was a long road for us but this has been long enough. 14 years ago was his first surgery today and he had a total colon and rectum removal. Some how the crohns fisucla through his back muscle and out the lower back skin. He has two holes in his intestine. Well thanks for listening tonight. Will keep u up to date ...
A Michigan man was saved when his dog alerted him to a bone infection from diabetes when he bit off the infected toe. The dog, Kiko, is currently being watched for signs of rabies, but otherwise the owner, Jerry Douthett of Rockford is thankful for his pets actions.
Immune Abnormalities; Pediatrics; Pediatric Infectious Diseases; Acute & Chronic Diseases and Conditions in Pediatric Patients; Bladder Infection; Bone Infection ...
Introducción. En los últimos años se observa un aumento de la prevalencia de colonización e infección por Scedosporium spp. en pacientes con fibrosis quística (FQ). En el presente estudio se registra la frecuencia de aislamiento de Scedosporium spp. en una Unidad de FQ de adultos, analizándose las características de los pacientes y los factores predisponentes.. Métodos. Se realizó un estudio observacional retrospectivo en 87 pacientes adultos con FQ en los que se valoró la presencia de cultivo positivo para Scedosporium spp. durante 5 años (enero de 2012-julio de 2017). Se recogieron las siguientes variables clínicas: edad, sexo, índice de masa corporal, genotipo, presencia de insuficiencia pancreática, colonizaciones bacterianas, función pulmonar, complicaciones, exacerbaciones y tratamiento, así como puntuación Bhalla modificada de la última tomografía computarizada axial de alta resolución. Los resultados se analizaron con el paquete estadístico IBM SPSS Statistics ...
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TY - JOUR. T1 - Polymer coatings for biomedical applications. T2 - a review. AU - Smith, James R.. AU - Lamprou, Dimitrios. PY - 2014. Y1 - 2014. N2 - This review surveys some of the recent literature concerning the use of polymer coatings for a variety of biomedical applications. These have been grouped into six broad categories: orthopaedic materials, cardiovascular stents, antibacterial surfaces, drug delivery, tissue engineering and biosensors. These, to some extent overlapping, sections have been ordered such that the literature generally progresses from polymer coatings on metallic to non-metallic substrates. Polymer coatings can bestow a wide range of functionalities due to their various properties, such as antiwear characteristics, mechanical strength, corrosion protection, electrical conductivity, biocompatibility and surface chemistry. The review period is from 2011 to the present (mid-2013).. AB - This review surveys some of the recent literature concerning the use of polymer coatings ...
Consultant Trauma and Orthopaedics Specialities: Hand and wrist surgery. Special clinical interests: Dupuytrens disease, Hand Arthritis,. Research interests: Orthopaedic infection, Dupuytrens disease. Telephone: 01603 286145 Secretary: Helen van Raalte. Current membership(s) of professional National and Regional bodies:Royal College of Surgeons of Edinburgh, British Orthopaedic Association, British Society for Surgery of the Hand.. Degrees & Universities: BM BCh University of Oxford, PhD - Staphylococcal biofilms - University of Nottingham, FRCS (Tr and Orth). GMC number: 4324032 Professional Expertise: I qualified from Oxford University and undertook surgical training in Nottingham. After working on the BBC series The Ship I completed a PhD on S.Aureus biofilms. I trained in Trauma and Orthopaedics in Trent before undertaking hand fellowships at the Pulvertaft Unit in Derby and an advanced training post in Sheffield. I am the lead clinician for hand trauma. Other interests include wrist ...
She graduated from the National and Kapodistrian University of Athens Medical School in 1969 when she also completed her PhD in 1976 on the pharmacokinetic properties of 2nd generation cephalosporins. She was trained in Infectious Diseases in London in 1980. She went through all ranks of hierarchy of the National and Kapodistrian University of Athens Medical School as lecturer in 1979, Assistant Professor in 1989, Associate Professor in 2000 and Professor of Internal Medicine and Infectious Diseases in 2011. She is currently Emeritus Professor of Internal Medicine and Infectious Diseases of the National and Kapodistrian University of Athens. Her main research interests are the pharmacokinetics of newer antimicrobials and the management of orthopedic infections with the use of elution systems. She has published 82 peer-reviewed articles in international journals with more than 1,000 citations.. ...
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PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Bacteremia, Bone infection (Osteomyelitis), Intraabdominal Infection, Joint Infection, Skin or Soft Tissue Infection, Urinary Tract ...
Mesentechs bone targeting technology allows for the development of multiple products across a wide-range of clinical conditions, from bone regeneration, to treatment of bone infections and cancers within bone.. ...
ClinDrops (clindamycin hydrochloride) for dogs and cats is indicated for infections of skin and oral tissues and bone infections. Inhibits of protein synthesis in bacterial cell with activity against a wide variety of aerobic and anaerobic bacteria.
Replied on 04/19/2011 First I would place an Elizabethan collar around your dogs neck so that he cannot reach the sore site. Is he using his leg normally and can he feel pain below the area that was injured? If he has lost pain perception in his leg or foot and the nerves are trying to regrow then he will have a constant tingling sensation (like when your foot falls asleep because you sit on it too long). He wont understand that feeling and he will lick until the sensation stops. This may take months to resolve. Because the wound is now down to his bone a bone infection is a huge concern. He definitely needs oral antibiotics and likely debridement surgery to clean the wound before the infection worsens and close it.. Its time to get him back to his veterinarian or seek a second opinion before this becomes an unsolvable problem.. ...
Vancin-S(vancomycin): Treatment of severe staphylococcal (including MRSA) infections eg, endocarditis, bone infection, septicemia, lower resp tract & s
Ciplox 500 mg (amoxicillin 500) capsule is use for treat for bacterial infections like joint and bone infections and salt of ciplox is Amoxycillin. Buy Ciplox 500 mg capsule online from PremiumRXdrugs
Cipro is a quinolone antibiotic. It is used to kill bacterias or hamper their growth. Ciprofloxacin can be used for treating different kinds of infections, like urinary, respiratory, skin, gastrointestinal, and bone infections. It will not be effective against colds, flu, or other viral infections. | Imedicine-online.com
Joint arthroplasty is a common and highly successful procedure; however, more than 1% of primary hip (1) and 1 to 3% of primary knee (2) arthroplasties fail due to periprosthetic joint infection (PJI). PJI carries a high risk of in-hospital and 5-year mortality (3, 4), and the cure rate after 2 years has been reported to be as low as 67% (5). These poor outcomes are due in part to incomplete knowledge of PJI disease etiology (6). In bone, osteoblasts (7) and osteoclasts (8) have been investigated in relation to bacterial infection. However, insufficient attention has been given to the role of the osteocyte in bone infection, despite this cell type constituting approximately 90 to 95% of cells in bone (9, 10). It has been reported that bacteria can reside in osteocytes in vivo (11, 12), and a recent study (13) demonstrated the ability of Staphylococcus aureus to invade the lacuno-canalicular spaces of cortical bone in an experimental osteomyelitis model, although infection of osteocytes per se ...
in A définir (2017). Long bone fracture constitutes a common reason for medical consultation within veterinary orthopedic services (Miller et al. 1998; Kumar et al. 2007). Canine bone fracture repair differs from the human ... [more ▼]. Long bone fracture constitutes a common reason for medical consultation within veterinary orthopedic services (Miller et al. 1998; Kumar et al. 2007). Canine bone fracture repair differs from the human case in the sense that (1) the physiological characteristics and morphology of the injured bones in animals vary considerably (Palierne et al. 2006), (2) the animal is not able to limit its activity during the post-operative period, leading to premature overloading, and (3) the surgeon is confronted to cost limitations concerning orthopedic material. There is a lack of studies assessing the effect of different treatment types on the biomechanical properties of a reconstructed bone, which may partly explain the frequent associated complications in the field of ...
The JVL Research Center, located on Orthopaedic Hospitals downtown campus, is one of two research components of the UCLA and Orthopaedic Hospital Department of Orthopaedic Surgery. The mission of the JVL Research Center is to develop a deeper understanding of the biology and biomechanics of the musculoskeletal system, and to apply this knowledge to the improvement of orthopaedic materials, implants, surgical instrumentation and surgical techniques, thereby improving the quality of care to orthopaedic patients world-wide.. Learn More ...
Edward M. Sherman, MD is a member of the DuPage Medical Group Infectious Disease & Travel Medicine Clinic departments seeing both children and adults in Lombard. Dr. Sherman has medical interests in general infectious diseases, HIV, orthopaedic infections and travel medicine.
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Osteomyelitis is inflammation of the bone caused by an infecting organism. Although bone is normally resistant to bacterial colonization, events such as trauma, surgery, presence of foreign bodies, or prostheses may disrupt bony integrity and lead to the onset of bone infection.
Looking for online definition of S.caprae in the Medical Dictionary? S.caprae explanation free. What is S.caprae? Meaning of S.caprae medical term. What does S.caprae mean?
Antirobe Caps are a highly effective antibiotic used to treat soft tissue infections (infected wounds and abscesses), dental infections (infected mouth cavity), and bone infections (osteomyelitis) in cats and dogs. This particular medication is one of the most commonly prescribed antibiotics for pets. Antirobe Caps work by penetrating the source of the bacterial infection and suppressing further protein synthesis and growth ...
The pilot will generate a novel classification system of post-surgery complications within fracture treatment to identify improvement potentials with regard to innovative products, services and technologies. Next to minor complications influencing length of treatment or quality aspects, the three major complications bone infection, bone non-union and bone misalignment will be evaluated in the hospitals over a defined time frame of three months inclusion period and six months evaluation.. With the new EU Medical Device Regulations hospitals/doctors as well as manufacturers will have to make alterations to ensure implant safety. To meet this new requirements, the present pilot includes a MDR (Medical Device Regulation) sub-study. This study will provide information on how to ensure a constant monitoring of complications and irregularities occurring during the treatment of patients to assure patient safety and manufacturers data access. In this way, the study will support the improvement of ...
For patients having a bone or joint infections, with or without device, optimal surgical therapy could be sometimes non-feasible, especially in the elderly population. Therefore, a medical therapy with oral prolonged suppressive antibiotic therapy (PSAT) seems to be an option to prevent recurrence and prosthesis loosening.. Subcutaneous (SC) administration of injectable intravenous antibiotics as prolonged suppressive antibiotic therapy could be a convenient way when oral treatment is not available to facilitate ambulatory care, this practice being considered as routine care.. The aim of this study is to evaluate tolerance and efficacy of subcutaneous administration of antibiotics for prolonged suppressive antibiotic therapy in patients having this treatment as part of their routine care. ...
/PRNewswire/ -- BONESUPPORT™, an emerging leader in injectable bone substitutes for orthopedic trauma, bone infections and instrument augmentation related to...
Pony Girl, she is a Quarter Horse/Thoroughbred cross. Her mama was a registered Paint mare with beautiful color. Her daddy was a money winning racehorse, The Comic. She was only 23 (she would have been 24 this year) but had problem feet. She had a bone infection in a front foot that was manageable for a while then just festered. Until the last week her, her body condition and attitude/spirit were great, that foot just got the best of her. She was in a lot of pain, so it was almost easy to let her go. Honestly, the family felt better once she was laid to rest, knowing that she was no longer suffering. But, its still not the same knowing shes gone. As a kid, you think they will be here forever. Thanks for asking.. ReplyDelete ...
It undoubtedly reaches the indoor part of the tooth or periodontal, which might result in dental an infection. It is advised which you confer with a neighboring emergency oral facility as soon as the thing is the main indicators of a tooth infection, like poor breath, the level of sensitivity in the contaminated tooth, high temperature, dreadful design inside the mouth, and problem in opening up the mouth. If you leave it neglected, it will certainly induce major challenges for example oral cysts as well as a bone infection.. The succeeding components might possibly exacerbate the risk of tooth infection:. - Very bad dental health: If we overlook the health problems, not only it can raise the danger of oral an infection, yet furthermore the potential threat of other dental and dental Conditions and ailments will certainly raise. These include a dental cavity and also gum problems. It is normally recommended to clean your tooth frequently as well as utilize floss.. - About-use of sugary foods: ...
1 Answer - Posted in: keflex, sulfatrim, diabetes, type 2, bone infection - Answer: It can work quite well for connective tissue problems (and ulcers ...
This trial is investigating the efficacy of gentamicin impregnated sponge [Collatamp] in patients with peri-prosthetic joint infection after a joint replacement
Generic Flagyl is a high-class medication which is taken in treatment and termination of serious bacterial diseases such as skin, vagina, gastrointestinal tract, stomach, joints infections. Generic Flagyl successfully wards off and terminates other infect
"Paediatric Immunology, Bone Marrow Transplantation and Infectious Diseases". Newcastle Hospitals. Retrieved 15 April 2018. "The ... The Great North Children's Hospital is one of two units in the UK which perform bone marrow transplants for children who were ...
Bone marrow testing is the most accurate.[5] Symptoms are similar to that of many other infectious diseases.[6] Typhus is a ... Anna E. Newton (2014). "3 Infectious Diseases Related To Travel". CDC health information for international travel 2014 : the ... Alan J. Magill (2013). Hunter's tropical medicine and emerging infectious diseases (9th ed.). London: Saunders/Elsevier. pp. ... involved in infectious diseases multiplied in the intestines of the sick, were present in their excretions, and could be ...
Bone-marrow testing is the most accurate.[4] Symptoms are similar to that of many other infectious diseases.[3] Typhus is an ... Clinical Infectious Diseases. 45: S24-S28. doi:10.1086/518141. PMID 17582564.. *^ a b Whitaker, J. A.; Franco-Paredes, C.; Del ... Alan J. Magill (2013). Hunter's tropical medicine and emerging infectious diseases (9th ed.). London: Saunders/Elsevier. pp. ... "Water-related Diseases." Communicable Diseases 2001. World Health Organization. 31 Oct 2008 ,. "Archived copy". Archived from ...
Bone loss and osteoclastogenesis are induced by inflammation in infectious and autoimmune diseases. A recent study has ... It has been shown to be involved in the onset of many diseases, which includes Inflammatory bowel disease. Recent studies have ... Activation of these genes results in robust osteoclast formation and bone loss. This process is absent in TLR5 knockout mice ... TLR5 may play a role in inflammatory bowel disease (IBD). TLR5-deficient mice develop spontaneous colitis and metabolic ...
Diseases of bone and joint (non-neoplastic and non-infectious disorders of bone, skeletal dysplasias/dysostoses, constitutional ... Destruction of part of the jaw bone may give the appearance of advanced gum disease. The cause is a genetic mutation in the ... The disease was once thought to be a lipid storage disease as the lesions have a high cholesterol content, but the blood ... In 1940, Louis Litchtenstein and Henry L. Jaffe described a self-limiting disease characterised by "isolated bone lesions". A ...
It causes disease in the joints, bones and respiratory system of birds. It is found throughout the world and infection may be ... referred to as Infectious Synovitis, Avian Mycoplasmosis, Infectious Sinusitis and Mycoplasma Arthritis. It is of economic ... The disease is most commonly seen in chickens, and transmission occurs both vertically and horizontally. Common clinical signs ... The disease is controlled with vaccination. Mycoplasma Mycoplasma synoviae, expert reviewed and published by Wikivet at http:// ...
Its areas of focus include study of infectious diseases, biodefense, military medicine, battlefield medicine, and bone marrow ... The Infectious Diseases Directorate conducts research on infectious diseases that are considered to be significant threats to ... The Naval Infectious Diseases Diagnostic Laboratory (NIDDL) is also located in the Silver Spring facility. NIDDL provides ... "Naval Infectious Diseases Diagnostic Laboratory". U.S. Naval Medical Research Center. Retrieved 25 July 2014. "NMRC Subordinate ...
The Journal of Infectious Disease "BK and JC virus: a review". Retrieved February 2, 2018. Viruses "Prion Disease and the ... The Journal of Clinical Investigation "Paget's Disease of Bone". Retrieved February 2, 2018. Chapter 44 of Medical Microbiology ... In some cases, the cause of prion diseases is known. Ingestion of a copy of an abnormally folded, infectious PrP can induce a ... However, TSEs are more correctly classified as prion diseases. Prions are misfolded proteins that are "infectious" because they ...
... focuses its efforts on several fields of immunodiagnostics: infectious diseases, bone and mineral, endocrinology, ... Infectious diseases • Gastrointestinal infections • Bone and mineral metabolism • Endocrinology • Hypertension • Oncology • ... The company is also active in molecular diagnostics for infectious diseases and for the detection of some forms of leukemia. ... DiaSorin develops, manufactures and markets tests for the diagnosis of infectious diseases or hormonal disorders. The ...
Infectious, such as Lyme disease and osteomyelitis. Neurological, such as spinal cord injury and vertebral degeneration. ... that innervate bone tissue leads to the sensation of bone pain. Bone pain originates from both the periosteum and the bone ... and other bone diseases. Thus there are several types of bone pain, each with many potential sources or origins of cause. From ... Paget's disease of bone (also termed osteitis deformans or ambiguously, just Paget's disease). Pain caused by cancer within ...
Stopping the spread of infectious disease was of utmost importance for maintaining a healthy society. The outbreak of disease ... Among his contributions to medicine was a textbook on the treatment of wounds, broken bones, and even tumors. ... Infectious Diseases in an Age of Change The Impact of Human Ecology and Behavior on Disease Transmission. National Academies ... This will be demonstrated through discussion of the major diseases of each continent. These diseases are sociologically ...
... as a burn or wound prevention and/or treatment of blood-borne pathogens treatment of infectious diseases management of bone and ...
... an extremely rare disease of bone. Benchmark changes in the understanding of medical science and the practice of medicine have ... lead the scientific advances behind the modern RotaTeq vaccine for infectious childhood diarrhea. In 2006, Drs. Kaplan and ...
... and inflammatory bowel disease Malignancy - bone metastasis from lung, breast, prostate, thyroid, among others Infectious - ... Low back pain (LBP) or lumbago is a common disorder involving the muscles, nerves, and bones of the back. Pain can vary from a ... Low back pain is not a specific disease but rather a complaint that may be caused by a large number of underlying problems of ... When a disc degenerates as a result of injury or disease, the makeup of a disc changes: blood vessels and nerves may grow into ...
... brittle bone disease, infectious proventriculitis, helicopter disease and pale bird syndrome). It consists of stunted growth in ... General hygiene and correct breeding conditions (especially correct brooding temperatures) may be efficient, but the disease ...
... synthesis and testing of novel antimicrobial therapeutics for in vivo and clinical applications in infectious bone disease. He ... Bad to the Bone: on in vitro and ex vivo microbial biofilm ability to directly destroy colonized bone surfaces without ... Working with chemists, Sedghizadeh designed and tested novel bone-targeted antibiotic conjugates to treat bone infections. ... Celiac disease and recurrent aphthous stomatitis: a report and review of the literature. Oral Surg Oral Med Oral Pathol Oral ...
... or Paget's disease of bone) Osteitis fibrosa cystica (or Osteitis fibrosa, or Von Recklinghausen's disease of bone) Osteitis ... More specifically, it can refer to one of the following conditions: Osteomyelitis, or infectious osteitis, mainly bacterial ... pubis Radiation osteitis Osteitis condensans ilii Panosteitis, a long bone condition in large breed dogs In horses, pedal ...
... a Short-term fellowship in Clinical Immunology and Bone Marrow Transplantation in Paediatric Immunology and Infectious Diseases ... He initiated the Iranian Primary Immunodeficiency Diseases Registry (IPIDR) in 1999 under supervision of Professor Asghar ... "Primary Immunodeficiency Diseases", Immunology of Aging" and "Cancer Immunology" series. He has also won the 12th and 18th Razi ... Northern Supra Regional Bone Marrow Transplant Unit for SCID and Related Disorders, Newcastle, UK, awarded by the ESID ( ...
BMC Infectious Diseases. 13 (1): 59. doi:10.1186/1471-2334-13-59. PMC 3565948. PMID 23374883. Russell, Jonathan R, Huang, ... Aspergillus tubingensis has also been implicated in the infection of maxillary bone following a tooth extraction. Oisewacz, ... "Infectious keratitis caused by Aspergillus tubingensis". Cornea. 28 (8): 951-954. doi:10.1097/ICO.0b013e3181967098. PMID ... "Involvement of the opportunistic pathogen Aspergillus tubingensis in osteomyelitis of the maxillary bone: a case report". ...
Sarkar R, Nair V, Sinha S, Garg VK, Rodriguez DA (2011). "7. Infectious diseases". In Taylor S, Gathers RC, Callender VD, ... Thabit AK, Fatani DF, Bamakhrama MS, Barnawi OA, Basudan LO, Alhejaili SF (April 2019). "Antibiotic penetration into bone and ... International Journal of Infectious Diseases. 81: 128-136. doi:10.1016/j.ijid.2019.02.005. PMID 30772469. Kumar P, Clark ML ( ... Despite having a lower than optimum drug penetration into bone ratio of 10-20%, flucloxacillin appears effective in treating ...
Emerging Infectious Diseases. U.S.: Centers for Disease Control and Prevention, United States Department of Health and Human ... Al, J. Rigaill et (2018). "Community-Acquired Staphylococcus argenteus Sequence Type 2250 Bone and Joint Infection, France, ...
If a patient has a life-threatening infectious complication then bone marrow transplantation is no longer relevant for them. ... In Gunther's disease, porphyrins are accumulated in the teeth and bones and an increased amount are seen in the plasma, bone ... There are a multiple ways to treat Gunther's diseases, but one of the most crucial things that a person with this disease can ... though a lack of hemolysis in this disease is possible. Porphyrins additionally accumulate in the bone and teeth, resulting in ...
... in infectious disease at the Massachusetts General Hospital and the National Institute of Allergy and Infectious Diseases. He ... Nir-Paz, Ran (March 2019). "Successful treatment of antibiotic resistant poly-microbial bone infection with bacteriophages and ... In 2016, while serving as the Head of the Division of Infectious Diseases at the UC San Diego School of Medicine, Schooley was ... In 1990, Schooley was recruited as the head of the Division of Infectious Diseases for the Health Sciences Center at the ...
Poly-microbial Bone Infection With Bacteriophages and Antibiotics Combination". Clinical Infectious Diseases. doi:10.1093/cid/ ... who was head of the Division of Infectious Disease at the UC San Diego School of Medicine at the time. Researchers from Texas A ...
Study of Chono bones reveal they were prone to suffer joint problems, infectious diseases and in some cases traumatic injuries ... These diseases were associated with their lifestyle. Scholar Alberto Trivera considers that there is no continuity between the ... Isotope studies of human bones found in former Chono territory suggest the Chonos maintained a chiefly marine-based diet over ...
However, no infectious virus has yet been isolated as a causative agent, and other evidence suggests an intrinsic ... and does not spread from bone to bone. Rarely, a bone affected by Paget's disease can transform into a malignant bone cancer. ... Ethel, SS; Roodman, GD (2008). "Paget's disease of bone". In Rosen. Primer on the metabolic bone diseases and disorders of ... Paget's Disease of Bone Overview - NIH Osteoporosis and Related Bone Diseases ~ National Resource Center. ...
Other problems include long hours of work, respiratory and skin diseases, life-threatening tetanus, joint and bone deformities ... non-HIV infectious diseases, and malaria was largely correlated with child labour. They concluded these results by saying that ... In the same study Willis found that prostituted children have higher rates of sexually transmitted diseases (STDs) than non- ...
Infectious Diseases and Pathology of Reptiles. CRC Press. p. 7. ISBN 978-0-8493-2321-8. Retrieved 2009-01-09. Taber, Clarence ... Pelvic girdle Right hip bone. Internal surface. Right hip bone. External surface. (Body of ilium is the top of the blue circle ... The brevis shelf is the bony ridge at the inner side of the fossa, the bone wall forming the internal face of the rear part of ... Crest of ilium is labeled at top.) Plan of ossification of the hip bone. Left hip-joint, opened by removing the floor of the ...
Schmitt, SK (June 2017). "Reactive Arthritis". Infectious Disease Clinics of North America (Review). 31 (2): 265-77. doi: ... "OrthoKids - Osgood-Schlatter's Disease". "Sever's Disease". Kidshealth.org. Retrieved 2014-04-29. CS1 maint: discouraged ... Examples include: Osgood-Schlatter disease (apophysitis of the tibial tubercle) Sever's disease (apophysitis of the posterior ... which is occasionally present Fifth metatarsal In the fifth metatarsal bone, the most proximal part of the bone is termed the " ...
MR1-Restricted Mucosal-Associated Invariant T Cells and Their Activation during Infectious Diseases. Frontiers in Immunology. ... bone marrow transplantation, and HIV-1 infection. Annual Review of Immunology. 2000, 18: 529-560. ISSN 0732-0582. PMID 10837068 ... Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease. Immunology. May 2016, 148 ( ... Modulation of autoimmune diseases by interleukin (IL)-17 producing regulatory T helper (Th17) cells. The Indian Journal of ...
Infectious disease deaths in Texas. *Songwriters from Texas. *Songwriters from Oklahoma. *Singers from Oklahoma ... trombone], Ray DeGeer [clarinet/sax], Zeb McNally [sax]) ...
Infectious Diseases (Systematic Review). 16 (3): e23-33. doi:10.1016/S1473-3099(15)00527-7. PMID 26852728. Archived (PDF) from ... and decreased bone mineral density, make its use for male acne impractical in most cases.[114][115][116] Pregnant and lactating ... This article is about a skin disease common during adolescence. For other acneiform skin diseases, see Acne (disambiguation). ... Disease Primers. 1: 15033. doi:10.1038/nrdp.2015.33. PMID 27227877.. *^ a b "Frequently Asked Questions: Acne" (PDF). U.S. ...
"Journal of Bone and Mineral Research. 22 (8): 1245-1259. doi:10.1359/jbmr.070420. PMID 17456009.. ... The results of this research was used as a model for Kashin-Beck disease. Kashin-Beck is a result of combinatorial ... giving rise to either bone or cartilage respectively. Osteochondroprogenitor cells are important for bone formation and ... Brian Keith Hall (2005). Bones and cartilage: developmental and evolutionary skeletal biology. Academic Press. pp. 150-. ISBN ...
... due to high fatalities from epidemics of infectious diseases carried by Europeans, such as measles and smallpox, to which they ... beating thigh bones on their palms to drive animals to the river, where they could be killed easily. Other methods of hunting ... By 1682, when William Penn arrived to his American commonwealth, the Lenape had been so reduced by disease, famine, and war ... Lenape communities were weakened by newly introduced diseases originating in Europe, mainly smallpox but also cholera, ...
The disease is most common in native laborers and in schoolchildren of the tropics and subtropics during the rainy season and ... Adriaans B, Hay R, Drasar B, Robinson D (January 1987). "The infectious aetiology of tropical ulcer--a study of the role of ... Deep tissue invasion: Often with bone involvement, and potentially leading to amputation.[citation needed] Chronic ulceration.[ ... In some of these countries, such as northern Papua New Guinea, it is the most common skin disease. It is also a frequent ...
Normally, the bone age is the same as the biological age but for some people, it is older. For many people with advanced bone ... disease of a major organ system, mistreatment, treatment with certain drugs, chromosomal deletions. Human growth hormone (HGH) ... When the cause is unknown, it is called idiopathic short stature.[5] Short stature can also be caused by the bone plates fusing ... However, in some cases, people who are naturally shorter combined with their advanced bone age, end up being even shorter than ...
Significant diseases. Cancer, bone fractures. Significant tests. screening tests, X-ray, CT, MRI, PET, bone scan, ... DEXA, or bone densitometry, is used primarily for osteoporosis tests. It is not projection radiography, as the X-rays are ... Usually the hip (head of the femur), lower back (lumbar spine), or heel (calcaneum) are imaged, and the bone density (amount of ... This is the standard method for bone densitometry. It is also used in CT pulmonary angiography to decrease the required dose of ...
... and the widespread transmission of infectious diseases spread through livestock and crops.[8] Humans both create and destroy ... Reconstructed woolly mammoth bone hut, based on finds in Mezhyrich.. The passenger pigeon was a species of pigeon endemic to ... Disease has to be very virulent to kill off all the individuals in a genus or species, and even such a virulent disease as West ... DiseaseEdit. The hyperdisease hypothesis, proposed by Ross MacPhee in 1997, states that the megafaunal die-off was due to an ...
All of these factors are closely associated with the increased spread of infectious disease.[205] ... witness the skulls and bones which were to be seen there in the months following the famine."[244] ... disease had become the most common cause of death.[205] Disease-related mortality then continued to take its toll through early ... and provided a more hospitable environment for water-borne diseases such as cholera and malaria. Such diseases clustered around ...
... and systemic diseases that occur as a result of kidney disease, such as renal osteodystrophy and hypertension. A physician who ... activated vitamin D supplements and phosphate binders may be required to counteract the effects of kidney failure on bone ... the study of normal kidney function and kidney disease, the preservation of kidney health, and the treatment of kidney disease ... Many diseases affecting the kidney are systemic disorders not limited to the organ itself, and may require special treatment. ...
Thus, similar immune systems may be more vulnerable to infectious diseases (see Major histocompatibility complex and sexual ... where their cranial bone length in the lower mandibular tooth row has changed. Having a high homozygosity rate is problematic ... "Polycystic Kidney Disease". www.vet.cornell.edu. Retrieved 2016-07-08.. *^ a b c Tave D (1999). Inbreeding and brood stock ... "Polycystic kidney disease , International Cat Care". icatcare.org. Retrieved 2016-07-08.. ...
These pollutants can cause gastrointestinal cancers and greater vulnerability to infectious diseases.[102] They can also be ... These vibrations are received through fatty tissues in the jaw, which is then rerouted into the ear-bone and into the brain ... This is followed by the colonization of bones and surrounding sediments (which contain organic matter) by enrichment ... Finally, sulfophilic bacteria reduce the bones releasing hydrogen sulfide enabling the growth of chemoautotrophic organisms, ...
... which makes the body more prone to a variety of infectious and non-infectious diseases. T-cell components associated with ... which is the organ essential for T-cell maturation following the migration of precursor cells from the bone marrow. This age- ... Ginaldi, L.; M.F. Loreto; M.P. Corsi; M. Modesti; M. de Martinis (2001). "Immunosenescence and infectious diseases". Microbes ... This has been implicated in the increasing frequency and severity of diseases such as cancer, chronic inflammatory disorders, ...
U.S. National Institutes of Health (NIH): Clinical Research Studies: National Institute of Allergy and Infectious Diseases ( ... Finally, some patients with STAT3 HIES have scoliosis, as well as bones that fracture easily.[15] ... Immunodeficiency Diseases (8th ed.). New York: McGraw-Hill Medical. ISBN 9780071621519.. *^ a b Grimbacher B, Holland S, Gallin ... Abnormal neutrophil chemotaxis due to decreased production of interferon gamma by T lymphocytes is thought to cause the disease ...
U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). *U.S. Army Medical Research Institute of Chemical ... The Anatomical Collections[22] are made up of bones and body parts. More than 5,000 skeletal specimens and 10,000 preserved ... and led the AMM into research on infectious diseases while discovering the cause of yellow fever. They contributed to research ... But new weapons and new environments bring new injuries, and epidemic disease remains a foe uniting all eras of combat. The ...
NAT - National Cancer Institute (NCI) - National Institute of Allergy and Infectious Diseases (NIAID) - National Institute of ... bone marrow - bone marrow suppression - booster - branched DNA assay - breakthrough infection - Broadway Cares/Equity Fights ... efficacy - empirical - encephalitis - end-stage disease - endemic - endogenous - endoscopy - endotoxin - endpoint - enteric - ... HIV disease - HIV prevention trials network (HPTN) - HIV set point - HIV vaccine trials network (HVTN) - HIV-1 - HIV-2 - HIV- ...
International Journal of Infectious Diseases 25: 32-7. doi:10.1016/j.ijid.2014.03.1397. PMID 24841930. ... Baer, William S. (1931). "The treatment of chronic osteomyelitis with the maggot (larva of the blow fly)". The Journal of Bone ...
Infectious diseases - viral (AIDS, SARS, West Nile encephalitis, hepatitis, herpes, measles, others), bacterial (TB, typhoid, ... Miscellaneous - ECMO, kidney or bone marrow transplant, hemodialysis, kidney failure, severe burn, celiac disease, severe acute ... It rises in response to allergies, parasitic infections, collagen diseases, and disease of the spleen and central nervous ... Chronic inflammation - especially juvenile rheumatoid arthritis, rheumatoid arthritis, Still's disease, Crohn's disease, ...
"Journal of Thoracic Disease. 7 (8): 1311-1322. doi:10.3978/j.issn.2072-1439.2015.06.11. PMC 4561280. PMID 26380759.. ... Turbinectomy is a surgical procedure in which all or some of the turbinate bones are removed to relieve nasal obstruction. ... and OSA is fairly common in acute cases of severe infectious mononucleosis. Temporary spells of OSA syndrome may also occur in ... Stroke and other cardiovascular disease are related to OSA and those under the age of 70 have an increased risk of early death. ...
In the intestines or lungs, movement by peristalsis or cilia helps to remove infectious agents.[4] Also, mucus traps infectious ... They are usually the first cells to arrive at the site of an infection.[5] The bone marrow of a normal healthy adult produces ... Stvrtinová, Viera; Ján Jakubovský and Ivan Hulín (1995). Inflammation and fever; from Pathophysiology: principles of disease. ... They are produced by blood-forming stem cells in the bone marrow.[1] ...
"Emerging Infectious Diseases. 8 (9): 971-975. doi:10.3201/eid0809.010536. ISSN 1080-6040.. ... When we were journeying through that land we came across countless skulls and bones of dead men lying about on the ground. Kiev ... Disease devastated all the khanates, cutting off commercial ties and killing millions.[101] Plague may have taken 50 million ... Disease ravaged the Mongol forces with bloody epidemics, and Möngke died there on 11 August 1259. This event began a new ...
A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases ... Some pain above the pubic bone or in the lower back may be present. People experiencing an upper urinary tract infection, or ... Bryan, Charles S. (2002). Infectious diseases in primary care. Philadelphia: W.B. Saunders. p. 319. ISBN 978-0-7216-9056-8. . ... Infectious disease. Symptoms. Pain with urination, frequent urination, feeling the need to urinate despite having an empty ...
... helps remove infectious agents.[2] Also, mucus traps infectious agents.[2] The gut flora can prevent the colonization of ... "Pathophysiology: Principles of Disease. Computing Centre, Slovak Academy of Sciences: Academic Electronic Press. Archived from ... The bone marrow of a normal healthy adult produces more than 100 billion neutrophils per day, and more than 10 times that many ... Acting as a physical and chemical barrier to infectious agents; via physical measures like skin or tree bark and chemical ...
Various (January 14, 2010). "Resources and Links, HIV-AIDS Connection". National Institute of Allergy and Infectious Diseases. ... "A Doctor, a Mutation and a Potential Cure for AIDS: A Bone Marrow Transplant to Treat a Leukemia Patient Also Gives Him Virus- ... "The Evidence That HIV Causes AIDS". National Institute of Allergy and Infectious Diseases (2003). பார்த்த நாள் 2008-12-20. ... Recommendations from CDC, the National Institutes of Health, and the HIV Medicine Association/Infectious Diseases Society of ...
... predicts increased infectious disease mortality in patients undergoing hemodialysis". Clinical Infectious Diseases. 48 (4): 418 ... "FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis". Proceedings of the ... "Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease". Annals of Dermatology. 24 (2): 126-35 ...
He was the first to establish a link between infectious diseases between humans and animals, for which he coined the term " ... Virchow broke his thigh bone on 4 January 1902, jumping off a running streetcar while exiting the electric tramway. Although he ... Anti-germ theory of diseasesEdit. Virchow did not believe in the germ theory of diseases, as advocated by Louis Pasteur and ... Virchow's disease, leontiasis ossea, now recognized as a symptom rather than a disease ...
Causes and transmission of infectious diseases[edit]. See also: Infection. Infections may be caused by bacteria, viruses, fungi ... Møller M; El Maghrabi R; Olesen N; Thomsen VØ (November 2004). "Safe inoculation of blood and bone marrow for liquid culture ... There are four kinds of microorganisms that cause infectious disease: bacteria, fungi, parasites and viruses, and one type of ... Diagnosis of infectious disease is nearly always initiated by consulting the patient's medical history and conducting a ...
Mouth diseases include tongue diseases and salivary gland diseases. A common gum disease in the mouth is gingivitis which is ... They are made of a bone-like material called dentin, which is covered by the hardest tissue in the body-enamel.[8] Teeth have ... It can also arise as a result of other gastrointestinal diseases such as coeliac disease. Coeliac disease is an autoimmune ... Crohn's disease is a common chronic inflammatory bowel disease (IBD), which can affect any part of the GI tract,[45] but it ...
The Infectious Diseases Society of America advises that the draining of an abscess is not enough to address community-acquired ... Elston, Dirk M. (2009). Infectious Diseases of the Skin. London: Manson Pub. p. 12. ISBN 9781840765144. Archived from the ... Perianal abscesses can be seen in patients with for example inflammatory bowel disease (such as Crohn's disease) or diabetes. ... An abscess is a defensive reaction of the tissue to prevent the spread of infectious materials to other parts of the body. ...
An infectious bone disease is a bone disease primarily associated with an infection. An example is osteomyelitis. Root, Richard ... Clinical Infectious Diseases: A Practical Approach. Oxford University Press. p. 741. ISBN 9780195081039. Retrieved 5 December ...
Osteomyelitis of Parietal Bone in Melioidosis. Emerging Infectious Diseases. 2007;13(8):1257. doi:10.3201/eid1308.070479.. ... Principles and practice of infectious diseases. Vol. 2. Oxford (UK): Churchill Livingstone; 2005. p. 2622-32. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... usually part of a disseminated infection involving metaphyseal regions of long bones and vertebral bodies. Localized bone ...
Bone and Joint Infection: CD-Rom by Dennis L. Stevens from Waterstones today! Click and Collect from your local Waterstones or ... Buy Atlas of Infectious Diseases: Skin, Soft Tissue, ... Atlas of Infectious Diseases: Skin, Soft Tissue, Bone and Joint ... Science, Technology & Medicine > Medicine > Clinical & internal medicine > Infectious & contagious diseases Science, Technology ... Atlas of Infectious Diseases S. (CD-ROM). Dennis L. Stevens (editor) Sign in to write a review ...
Babesiosis is an infectious disease. June 23, 2012 admin A - Z Dogs, Dog Accessories, Dog Behaviour, Dog Care, Dog Training, ... Babesiosis is an infectious disease caused by a Protozoan (unicellular organism) called babesia intraeritrocitico (which is ... The clinical picture varies from percussion caps boxes (sharps) to mild, even limiting, so the disease is often go unnoticed, ... The treatment of choice today is to treat the parasitic disease with specific antiparasitics (Diminazeno Aceturato and ...
"Bone Diseases, Infectious" by people in this website by year, and whether "Bone Diseases, Infectious" was a major or minor ... "Bone Diseases, Infectious" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Bone Diseases, Infectious*Bone Diseases, Infectious. *Bone Disease, Infectious. *Disease, Infectious Bone ... Below are the most recent publications written about "Bone Diseases, Infectious" by people in Profiles. ...
Bone Diseases: Infectious Bone Diseases: Osteoarticular Tuberculosis - OCOSH Classification: Bone Diseases: Spinal Diseases: ... OCOSH Classification: Bone Diseases: Infectious Bone Diseases: Osteoarticular Tuberculosis - OCOSH Classification: ... OCOSH Classification: Bone Diseases: Infectious Bone Diseases: Osteoarticular Tuberculosis - OCOSH Classification: ... OCOSH Classification: Bone Diseases: Infectious Bone Diseases: Osteoarticular Tuberculosis - OCOSH Classification: ...
Paloma F Cariello, MD, MPH is an Associate Professor of Infectious Diseases at the University of Utah School of Medicine. She ... Cariello PF, Madoff LC (2012). Emerging Infectious Diseases and Globalization. In Emerging Diseases. Brazil: Editora Atheneu. ... Interrnational Congress of Infectious Diseases, Miami, FL.. Case Report. *Cariello, PF, Goyal, D, Tsuha, S (2019). Pericardial ... Paloma F Cariello, MD, MPH is an Associate Professor of Infectious Diseases at the University of Utah School of Medicine. She ...
Non-infectious complications after bone marrow transplant: chronic graft-versus-host disease Celalettin Ustun ... Non-infectious complications after bone marrow transplant: chronic graft-versus-host disease. What every physician needs to ... Non-infectious complications after bone marrow transplant: chronic graft-versus-host disease*What every physician needs to know ... Close more info about Non-infectious complications after bone marrow transplant: chronic graft-versus-host disease ...
... patients with MS and other brain and central nervous system disorders and diseases. ... Non-infectious complications after bone marrow transplant: acute graft-versus-host disease. What every physician needs to know ... Non-infectious complications after bone marrow transplant: acute graft-versus-host disease. *By ... Non-infectious complications after bone marrow transplant: acute graft-versus-host disease ...
Bone And Joint Infections An Issue Of Infectious Disease Clinics Of North America 1st Edition Author Steven K Schmitt Dr ... Schmitt Has Put Together A Comprehensive Issue Devoted To Bone And Joint Infections ... First online issue of journal of bone and joint diseases online editorial journal of bone and joint diseases a new beginning ... Bone And Joint Infections An Issue Of Infectious Disease PDF, ePub eBook ...
... bone formation as well as bone resorption markers decreased significant. We postulate a protective effect on bone structure ... We measured the bone turnover markers in 96 HIV-infected patients: Bone specific alkaline phosphatase (BSAP), Pyridinoline (PYR ... Moreover, bone turnover markers are increased in patients on antiretroviral therapy and vitamin D deficiency is prevalent in ... 25OH-vitamin D and bone turn over markers were determinded 3 month later. 25 OH-vitamin D was corrected for circannual rythm y ...
Promoting behavioral changes in food intake and lifestyle, aimed at the primary prevention of bone disease in the chronically- ... Both biochemical bone turnover markers and BMD, assessed by dual-energy radiographic absorptiometry (DXA) were recorded in the ... there have been no previous studies examining dairy calcium intake and bone mineral density (BMD) in HIV-subjects. We assessed ... Figure 1 , BMC Infectious Diseases. Figure 1. From: Dairy calcium intake and lifestyle risk factors for bone loss in hiv- ...
Non-infectious complications after bone marrow transplant: chronic graft-versus-host disease Celalettin Ustun ... Non-infectious complications after bone marrow transplant: chronic graft-versus-host disease What every physician needs to know ... Non-infectious complications after bone marrow transplant: chronic graft-versus-host disease *What every physician needs to ... Close more info about Non-infectious complications after bone marrow transplant: chronic graft-versus-host disease ...
... What every physician needs to know ... Non-infectious complications after bone marrow transplant: acute graft-versus-host disease. *By ... Non-infectious complications after bone marrow transplant: acute graft-versus-host disease ... What conditions can underlie non-infectious complications after bone marrow transplant: acute graft-versus-host disease: * ...
Published on behalf of Infectious Diseases Society of America Volume 33, issue 7, pages 947-953. Published in print October ... Bacteria remain an important cause of infection in bone marrow transplants. To examine shifts in the etiology and ... Bacteria remain an important cause of infection in bone marrow transplants. To examine shifts in the etiology and ...
Non-infectious complications after bone marrow transplant: acute graft-versus-host disease Celalettin Ustun ... Non-infectious complications after bone marrow transplant: acute graft-versus-host disease. What every physician needs to know ... Non-infectious complications after bone marrow transplant: acute graft-versus-host disease*What every physician needs to know ... What conditions can underlie non-infectious complications after bone marrow transplant: acute graft-versus-host disease:* ...
The Infectious Diseases Management Program (IDMP) at UCSF is an interprofessional and interhospital collaboration aimed at ... 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot ... Home » Hospitalized Adults: Bone & Joint Infections: Osteomyelitis. Hospitalized Adults: Bone & Joint Infections: Osteomyelitis ... Obtain bone biopsy to determine microbiologic cause prior to initiation of antimicrobial therapy if blood cultures are negative ...
Published on behalf of Infectious Diseases Society of America Volume 25, issue 6, pages 1295-1302. Published in print December ... Bone and joint infections are difficult to cure. The difficulty is related to the presence of bacteria adherent to foreign ... Bone and joint infections are difficult to cure. The difficulty is related to the presence of bacteria adherent to foreign ... Clinical trials are difficult to design because of the heterogeneity of the disease and the number of factors that could ...
The Infectious Diseases Management Program (IDMP) at UCSF is an interprofessional and interhospital collaboration aimed at ... Home » Hospitalized Adults: Bone & Joint Infections: Septic Arthritis. Hospitalized Adults: Bone & Joint Infections: Septic ...
Dhurve, S. A. (2013). BONE MARROW ABONRMALITIES IN HIV INFECTION. Mediterranean Journal of Hematology and Infectious Diseases, ... The Mediterranean Journal of Hematology and Infectious Diseases [eISSN 2035-3006]. is owned by the U.C.S.C. and it is published ... Bone marrow abnormalities occur in all stages of HIV infection. Present work was carried out to study the bone marrow ... Bone marrow was normocellular in 79.06% of non-AIDS and 79.68% of AIDS, hypocellular in 13.95%.Thrombocytopenia was seen in 4 ...
... , Critical Illness Related Metabolic Bone Disease, Osteoporosis Secondary to ICU ... Infectious Disease Book Jokes Book Mental Health Book Neonatology Book Nephrology Book Neurology Book Obstetrics Book ... Metabolic Bone Disease Following ICU Admission. Metabolic Bone Disease Following ICU Admission Aka: Metabolic Bone Disease ... Search other sites for Metabolic Bone Disease Following ICU Admission NLM Pubmed Google Websites Google Images QuackWatch ...
Humans have a high degree of resistance to foot-and-mouth disease, for example, while the cattle and sheep with which they may ... Rats are highly resistant to diphtheria, whereas unimmunized children readily contract the disease. What such resistance ... Every animal species possesses some natural resistance to disease. ... bone disease* In bone disease: Infectious diseases of bone. *Central African history* In Central Africa: Development of the ...
The Mediterranean Journal of Hematology and Infectious Diseases [eISSN 2035-3006]. is owned by the U.C.S.C. and it is published ... BONE MARROW BLASTS. Mediterranean Journal of Hematology and Infectious Diseases, 5(1), e2013032. https://doi.org/10.4084/mjhid. ... Patients with ≥ 20% ,30% bone marrow blast infiltration previously regarded as a transitional category between myelodisplasia ... TREATMENT OF ACUTE MYELOID LEUKEMIA WITH 20-30% BONE MARROW BLASTS DOI https://doi.org/10.4084/mjhid.2013.032 ...
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Learn about who is at risk for osteomyelitis and how these bone infections are treated and diagnosed. ... ClinicalTrials.gov: Bone Diseases, Infectious (National Institutes of Health) * ClinicalTrials.gov: Osteomyelitis (National ... People who are at risk for bone infections include those with diabetes, poor circulation, or recent injury to the bone. You may ... Bone pain or tenderness (Medical Encyclopedia) Also in Spanish * Disseminated tuberculosis (Medical Encyclopedia) Also in ...
Bone Diseases, Infectious. Infection. Bone Diseases. Musculoskeletal Diseases. Spinal Diseases. Spondylarthropathies. ... Patients who have demyelinating disease or with a history of demyelinating disease ... Bath ankylosing spondylitis Disease Activity Index [ Time Frame: at week 24 ]. Secondary Outcome Measures : *Effectiveness ... Bath ankylosing spondylitis Disease Activity Index [ Time Frame: at week 12 ]. *Number of patients with adverse events [ Time ...
Bone Diseases, Infectious. Infection. Bone Diseases. Musculoskeletal Diseases. Spinal Diseases. Spondylarthropathies. ... IBD (Crohns disease or ulcerative colitis) and psoriaris are extra-articular manifestations of AS involving the intestinal ... Annual Incidence Rate of New-Onset or Flares of Inflammatory Bowel Disease (IBD) and Psoriasis in Participants Before Anti-TNF/ ... Percentage of Bath Ankylosing Spondylitis Disease Activity Index 50 (BASDAI 50) Responders Following Treatment With GLM [ Time ...
Bone Diseases, Infectious. Infection. Bone Diseases. Musculoskeletal Diseases. Spinal Diseases. Spondylarthropathies. ... History of ongoing, chronic or recurrent infectious disease or evidence of tuberculosis infection. ... Condition or disease Intervention/treatment Phase Ankylosing Spondylitis Drug: Secukinumab (AIN457) 150 mg s.c. Drug: Placebo ... The Short Form-36 Health Survey (SF-36) measures the impact of disease on overall quality of life by assessing 1) limitations ...
Bone Diseases, Infectious. Infection. Bone Diseases. Musculoskeletal Diseases. Spinal Diseases. Spondylarthropathies. ... Program evaLuating the Autoimmune Disease iNvEstigational Drug cT-p13 in AS Patients(PLANETAS). The safety and scientific ... Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) at Weeks 14, 30 and 54 compared with Baseline [ Time Frame: at week ...
Parathyroid disease. *Muscle diseases. *Bone disease. *Elevated blood calcium (hypercalcemia). *Infectious diseases ... Fibromyalgia is not a form of arthritis (a disease of the joints), but rather a muscle disorder. Fibromyalgia and arthritis can ... It is common for fibromyalgia to be associated with another joint disease, such as systemic lupus or rheumatoid arthritis. ... National Institute of Arthritis and Musculoskeletal and Skin Diseases: "Questions and Answers about Fibromyalgia" ...

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