Diseases of BONES.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Ductless glands that secrete HORMONES directly into the BLOOD CIRCULATION. These hormones influence the METABOLISM and other functions of cells in the body.
Bone loss due to osteoclastic activity.
The system of glands that release their secretions (hormones) directly into the circulatory system. In addition to the ENDOCRINE GLANDS, included are the CHROMAFFIN SYSTEM and the NEUROSECRETORY SYSTEMS.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.
Tumors or cancer located in bone tissue or specific BONES.
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.
Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.
Tumors or cancer of the ENDOCRINE GLANDS.
Exogenous agents, synthetic and naturally occurring, which are capable of disrupting the functions of the ENDOCRINE SYSTEM including the maintenance of HOMEOSTASIS and the regulation of developmental processes. Endocrine disruptors are compounds that can mimic HORMONES, or enhance or block the binding of hormones to their receptors, or otherwise lead to activating or inhibiting the endocrine signaling pathways and hormone metabolism.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Dissolution of bone that particularly involves the removal or loss of calcium.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC
Breaks in bones.
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.
Syndromes of bone destruction where the cause is not obvious such as neoplasia, infection, or trauma. The destruction follows various patterns: massive (Gorham disease), multicentric (HAJDU-CHENEY SYNDROME), or carpal/tarsal.
The process of bone formation. Histogenesis of bone including ossification.
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.
Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
The largest of three bones that make up each half of the pelvic girdle.
A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.
A VITAMIN D that can be regarded as a reduction product of vitamin D2.
A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)
The grafting of bone from a donor site to a recipient site.
Diseases of the bones related to hyperfunction or hypofunction of the endocrine glands.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.
A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are MEN1 and MEN2 with gene mutations on CHROMOSOME 11 and CHROMOSOME 10, respectively.
A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.
Abnormally high level of calcium in the blood.
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Stable strontium atoms that have the same atomic number as the element strontium, but differ in the atomic weight. Sr-84, 86, 87, and 88 are the stable strontium isotopes.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).
Death of a bone or part of a bone, either atraumatic or posttraumatic.
A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.
A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.
Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.
A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.
A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher.
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
An abnormal hardening or increased density of bone tissue.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.
Tumors or cancer of the human BREAST.
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.
Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.
Bone diseases caused by pathogenic microorganisms.
COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Cells found throughout the lining of the GASTROINTESTINAL TRACT that contain and secrete regulatory PEPTIDE HORMONES and/or BIOGENIC AMINES.
Inorganic compounds that contain TECHNETIUM as an integral part of the molecule. Technetium 99m (m=metastable) is an isotope of technetium that has a half-life of about 6 hours. Technetium 99, which has a half-life of 210,000 years, is a decay product of technetium 99m.
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.
Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
Elements of limited time intervals, contributing to particular results or situations.
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
Excision of one or more of the parathyroid glands.
Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
Inorganic salts of phosphoric acid.
Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.
A coronary vasodilator agent.
A circular structural unit of bone tissue. It consists of a central hole, the Haversian canal through which blood vessels run, surrounded by concentric rings, called lamellae.
Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.
A condition of an abnormally low level of PHOSPHATES in the blood.
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
Formation of stones in the KIDNEY.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
AMINO ACIDS composed of GLYCINE substituted at the nitrogen rather than the usual carbon position, resulting in the loss of HYDROGEN BONDING donors. Polymers of these compounds are called PEPTOIDS.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.
A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia.
The spinal or vertebral column.
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC
The bone that forms the frontal aspect of the skull. Its flat part forms the forehead, articulating inferiorly with the NASAL BONE and the CHEEK BONE on each side of the face.
Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.
A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.
Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.
A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.
Pathologic deposition of calcium salts in tissues.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Local surroundings with which cells interact by processing various chemical and physical signals, and by contributing their own effects to this environment.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The surgical removal of one or both ovaries.
Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.
A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.
A benign tumor of the pancreatic ISLET CELLS. Usually it involves the INSULIN-producing PANCREATIC BETA CELLS, as in INSULINOMA, resulting in HYPERINSULINISM.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
Surgery performed on any endocrine gland.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
The bones of the free part of the lower extremity in humans and of any of the four extremities in animals. It includes the FEMUR; PATELLA; TIBIA; and FIBULA.
Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.
A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
Tumors or cancer of the PROSTATE.
Removal of bone marrow and evaluation of its histologic picture.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Fractures of the femur.
A GASTRIN-secreting neuroendocrine tumor of the non-beta ISLET CELLS, the GASTRIN-SECRETING CELLS. This type of tumor is primarily located in the PANCREAS or the DUODENUM. Majority of gastrinomas are malignant. They metastasize to the LIVER; LYMPH NODES; and BONE but rarely elsewhere. The presence of gastrinoma is one of three requirements to be met for identification of ZOLLINGER-ELLISON SYNDROME, which sometimes occurs in families with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; (MEN 1).
The five cylindrical bones of the METACARPUS, articulating with the CARPAL BONES proximally and the PHALANGES OF FINGERS distally.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A group of acidic proteins that are major components of SECRETORY GRANULES in the endocrine and neuroendocrine cells. They play important roles in the aggregation, packaging, sorting, and processing of secretory protein prior to secretion. They are cleaved to release biologically active peptides. There are various types of granins, usually classified by their sources.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Inorganic or organic compounds that contain the basic structure RB(OH)2.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
The giving of drugs, chemicals, or other substances by mouth.
A cell line derived from cultured tumor cells.
An almost always malignant GLUCAGON-secreting tumor derived from the PANCREATIC ALPHA CELLS. It is characterized by a distinctive migratory ERYTHEMA; WEIGHT LOSS; STOMATITIS; GLOSSITIS; DIABETES MELLITUS; hypoaminoacidemia; and normochromic normocytic ANEMIA.
The five long bones of the METATARSUS, articulating with the TARSAL BONES proximally and the PHALANGES OF TOES distally.
The seven bones which form the tarsus - namely, CALCANEUS; TALUS; cuboid, navicular, and the internal, middle, and external cuneiforms.
CCR receptors with specificity for a broad variety of CC CHEMOKINES. They are expressed at high levels in MONOCYTES; tissue MACROPHAGES; NEUTROPHILS; and EOSINOPHILS.
A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)
Cholecalciferols substituted with two hydroxy groups in any position.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
Tumors or cancer of the ADRENAL GLANDS.
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Peptide hormones secreted into the blood by cells in the ISLETS OF LANGERHANS of the pancreas. The alpha cells secrete glucagon; the beta cells secrete insulin; the delta cells secrete somatostatin; and the PP cells secrete pancreatic polypeptide.

Vitamin D receptor activators can protect against vascular calcification. (1/1)


Shunmugavel, S., Tosi, I., H. Rasmussen, K., E. Jensen, R., Taarning, E., Meier, S. & Riisager, A., 2016. 1 p.. Research output: Contribution to conference › Conference abstract for conference › Research › peer-review ...
  • As a faculty member, Dr. Shah aims to provide exceptional care to patients with a wide variety of endocrine disorders, and mentorship to fellows, residents and medical students. (mountsinai.org)
  • Intensive Review of Endocrinology and Metabolism is a wide-ranging board review of endocrine disorders. (cmelist.com)
  • This Metabolic Diseases Branch sees patients with disorders of calcium metabolism and metabolic bone disease, including sporadic and familial forms of primary hyperparathyroidism (e.g. (nih.gov)
  • Radiologic manifestations in the musculoskeletal system of miscellaneous endocrine disorders. (gentili.net)
  • There is no cure for fibrous dysplasia although bone fractures or deformities are treated as are related endocrine disorders. (ucihealth.org)
  • The purpose of the pre-departure medical examination is to identify applicants with health-related grounds for inadmissibility (i.e., diseases of public health significance, substance use disorders, mental illness with harmful associated behaviors). (cdc.gov)
  • The Johns Hopkins Division of Endocrinology, Diabetes, and Metabolism leads the pursuit of biomedical discovery related to diabetes, endocrine and metabolic disorders. (hopkinsmedicine.org)
  • Our cutting-edge research is making breakthroughs in the pathophysiology and treatment of diabetes, obesity, metabolic bone diseases, metabolic effects of HIV infection or cystic fibrosis, thyroid cancer, pituitary and reproductive disorders. (hopkinsmedicine.org)
  • Many endocrine disorders - or hormone disorders - are caused by hormone imbalances that can affect nearly every part of the body down to the cellular level. (pennstatehealth.org)
  • Most endocrine disorders are also chronic diseases that require lifelong management. (pennstatehealth.org)
  • Many endocrine disorders are lifelong conditions that require regular doctor visits and self-care. (pennstatehealth.org)
  • Through these studies, we hope to improve our understanding of endocrine disorders and the methods used to treat them, which, in turn, will improve the lives of those living with these conditions. (pennstatehealth.org)
  • This battery of measurements are used in the diagnosis and treatment of certain liver, heart, and kidney diseases, acid-base imbalance in the respiratory and metabolic systems, other diseases involving lipid metabolism and various endocrine disorders as well as other metabolic or nutritional disorders. (cdc.gov)
  • Its exact pathogenesis is still not fully understood, but it may have systemic origins associated with debilitating infections, endocrine disorders, bone disease (Paget's disease) or radiotherapy, but it can also be idiopathic 2 . (bvsalud.org)
  • Autoimmune diseases are a group of chronic disorders in which the body's immune system mistakenly attacks and damages healthy cells and tissues. (medlineplus.gov)
  • Diseases Treatments Dictionary Complete solution for all diseases && disorders treatments. (diseasesdic.com)
  • Gigantism and acromegaly are two disorders with the same disease mechanism and somewhat similar presentations. (nftartranking.com)
  • This article will discuss the disease mechanism and the clinical features, symptoms, causes, investigation and diagnosis, and prognosis of acromegaly and gigantism, and also the difference between the two disorders. (nftartranking.com)
  • This year's program will focus on laminitis and endocrine disorders. (blogspot.com)
  • Association of Hypertensive Disorders of Pregnancy With Future Cardiovascular Disease. (cdc.gov)
  • Is there evidence for an association between hypertensive disorders of pregnancy (HDPs) and long-term risk of cardiovascular disease? (cdc.gov)
  • She then completed her fellowship training in Endocrinology, Diabetes and Bone diseases at the Icahn School of Medicine at Mount Sinai. (mountsinai.org)
  • With this need in mind, in 2002, we established a training program at Johns Hopkins devoted to clinical and epidemiologic research in diabetes and endocrinology and funded by the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK). (hopkinsmedicine.org)
  • Founded in 1916, The Endocrine Society is the world's oldest, largest, and most active organization devoted to research on hormones and the clinical practice of endocrinology. (guidelinecentral.com)
  • Committees and members of The Endocrine Society and the European Society of Endocrinology reviewed and commented on preliminary drafts of these guidelines. (bvsalud.org)
  • Despite the reported high prevalence of osteoporosis in the human immunodeficiency virus (HIV)-population, there have been no previous studies examining dairy calcium intake and bone mineral density (BMD) in HIV-subjects. (biomedcentral.com)
  • Osteoporosis, like the name suggests, is a disease of "porous bones. (medicalnewstoday.com)
  • Osteoporosis makes the bones thin, weak, and brittle. (medicalnewstoday.com)
  • The International Osteoporosis Foundation say that 1 in 3 women and 1 in 5 men over the age of 50 will experience a broken bone because of osteoporosis. (medicalnewstoday.com)
  • Most people do not show symptoms, making osteoporosis a "silent disease. (medicalnewstoday.com)
  • Supportive measures include folic acid replacement and monitoring for the development of complications such as pulmonary hypertension, osteoporosis, and bone fractures, poor dentition, heart failure, and aplastic crisis with parvovirus B-19 infection. (medscape.com)
  • Osteoporosis is weakening of the bones. (lifeextension.com)
  • This protocol will help you understand the causes of osteoporosis and steps to take that may help strengthen bones. (lifeextension.com)
  • Osteoporosis is a disease in which bone mass or bone density is reduced. (lifeextension.com)
  • when more bone is resorbed than reformed, osteoporosis results. (lifeextension.com)
  • Natural interventions such as isoflavones and vitamin K may help maintain healthy bones and prevent osteoporosis from developing. (lifeextension.com)
  • Other natural interventions that may support bone health and help prevent osteoporosis include boron , curcumin , resveratrol , quercetin , berberine , and hops . (lifeextension.com)
  • Other endocrine diseases, like hypothyroidism and osteoporosis are also extraordinarily common. (hopkinsmedicine.org)
  • Osteoporosis is the most common cause of low bone mineral density. (massgeneral.org)
  • If you have a complex case, your doctor may refer you to Mass General Endocrine and Osteoporosis Associates for specialized care. (massgeneral.org)
  • DXA allows physicians to diagnose osteoporosis and related bone diseases early, often before you suffer a fracture. (massgeneral.org)
  • Although it does not cause death, menopause can decrease quality of life and lead to degenerative diseases especially bone loss or osteoporosis [2]. (bvsalud.org)
  • Osteoporosis is characterized by bone mineral density (BMD), thus increasing bone fragility and fracture risk. (bvsalud.org)
  • However, older thalassaemics may have to contend with multiple conditions including early osteoporosis, cardiac disease, pulmonary hypertension and diabetes, some of which result from increased iron deposition in the endocrine glands and myocardial cells. (who.int)
  • Low vitamin D also raises your risk for heart disease , diabetes , osteoporosis and other chronic diseases. (skinorganics.life)
  • Hypoparathyroidism is a rare endocrine disease that occurs when inadequate levels of parathyroid hormone (PTH) are secreted by the parathyroid glands, resulting in a mineral imbalance in the body which can have a significant impact on patients. (takeda.com)
  • Diseases of the bones related to hyperfunction or hypofunction of the endocrine glands. (bvsalud.org)
  • Mostly seen in dogs, Cushing's disease is where the adrenal glands overproduce certain hormones leading to problems body-wide. (vethelpdirect.com)
  • ACTH travels in the blood to the adrenal glands (lowly employees of the endocrine system) and tells them to release cortisol. (vethelpdirect.com)
  • Cushing's disease, or hyperadrenocorticism, is where a dog's adrenal glands produce too much cortisol (they can also overproduce other hormones, but cortisol is the main one). (vethelpdirect.com)
  • Erythrocytes in sickle form, cellular expression of polymerization of deoxygenated HbS, cause intermittent vascular obstruction, leading to tissue ischaemia and consequent chronic damage in organs and endocrine glands. (bvsalud.org)
  • There are certain exceptions such as 'endocrine data for the ethnic groups living in the registration area, e.g. glands, other' and 'thoracic organs, other' to avoid a long list of Japanese appear under Hawaii, Los Angeles and San Francisco. (who.int)
  • When the hypothalamus registers that we are stressed, it tells the pituitary gland (the supervisor of the endocrine system, found just below the brain) to release a hormone called adrenocorticotropic-hormone (ACTH for short). (vethelpdirect.com)
  • Hypothalamus secreting excessive amounts of Growth Hormone Releasing Hormone, anterior pituitary secreting excessive amounts of Growth Hormone, and excessive production of insulin like growth factor binding protein that prolongs IGF action are the three widely accepted disease mechanisms. (nftartranking.com)
  • She has participated as a co-investigator in several clinical trials related to Cushings disease. (mountsinai.org)
  • NIH faculty is dedicated to training endocrine fellows in the clinical and scientific basis of endocrine physiology and disease. (nih.gov)
  • The Diabetes, Endocrine, and Obesity Branch conducts clinical and basic research in the area of diabetes, insulin resistance, thyroid physiology and pathology, metabolism, and body weight regulation. (nih.gov)
  • Dr. Simeon Taylor , Distinguished Investigator, Special Volunteer, conducts clinical and translational research related to pharmacotherapy of metabolic disease - with a special emphasis on genetic factors that predict an individual patient's response to specific drugs (i.e. (nih.gov)
  • Dr. William Simonds , Chief, Endocrine Signaling & Oncogenesis Section, studies clinical and basic scientific aspects of familial isolated hyperparathyroidism, parathyroid cancer, and the hyperparathyroidism-jaw tumor syndrome, as well as the function of the G protein beta5/R7-RGS/ R7BP signaling complex expressed in neurons and endocrine tissue. (nih.gov)
  • 1. Does screening (clinical risk assessment, bone density measurement, or both) for osteoporotic fracture risk in adults reduce fractures and fracture-related morbidity and mortality? (uspreventiveservicestaskforce.org)
  • What is the evidence from modeling studies about the effectiveness of screening strategies (screening, clinical risk assessment, or bone density measurement) that use a) different ages at which to start and stop screening and b) different screening intervals? (uspreventiveservicestaskforce.org)
  • In clinical trials, BoD is often included in the non-visceral disease subgroup. (esmo.org)
  • These conditions can severely affect clinical management of the disease, especially in paediatric age. (springer.com)
  • Using these autoantibodies, organ-specific autoimmunity may be often detected before the development of clinical disease, in order to prevent significant morbidity related to unrecognized disease [ 1 ]. (springer.com)
  • These clinical and real-world studies reflect our commitment to advancing our knowledge of rare diseases and improving patient care. (takeda.com)
  • This is a specialist facility tackling diabetes and related metabolic and endocrine conditions to help improve the care of individuals with diabetes and other hormonal illnesses through combined excellence in inter-professional clinical care, education, innovation and translational research. (uhcw.nhs.uk)
  • There are 10 clinical examination rooms, a further two rooms provide dedicated facility for the operational requirements of the Diabetes Acute Foot Service, as well as other specialist areas enabling day to day research activity and specialist medical and endocrine nursing function. (uhcw.nhs.uk)
  • Some haemoglobinopathy genes ( alpha-thal, beta-thal and HbS ) cause alpha-thalassaemia, beta-thalassaemia and sickle-cell anaemia, respectively, but others ( HbE and HbC ) cause severe clinical manifestations of the disease only when combined with one of the former genes. (who.int)
  • The EMERALD Phase 3 clinical trial is a randomized study of 466 patients who had previously received either one or two lines of endocrine treatment including a cyclin-dependent kinase (CDK) 4/6 inhibitor. (hotprofitsclub.com)
  • From developing novel surgical techniques, to participating in national clinical trials to test new drugs, to advancing state-of-the-art imaging tools to study various eye diseases, we remain at the forefront of vision research. (froedtert.com)
  • Heart and Vascular clinical trials currently include PFO and Embolic CVA, peripheral vascular disease, electrophysiology and arrhythmia, cardiology imaging and advanced heart failure. (froedtert.com)
  • Our current neuroscience clinical trials focus on research for Alzheimer's and dementia, stroke, Parkinson's disease, spinal cord injury and traumatic brain injury. (froedtert.com)
  • Besides the subjectivity inherent to this way to collect data, the clinical course of a disease may be different for some patients with the same diagnosis. (vin.com)
  • Clinical hallmarks of VHL disease include the development of retinal and central nervous system (CNS) hemangioblastomas (blood vessel tumors), pheochromocytomas , multiple cysts in the pancreas and kidneys, and an increased risk for malignant transformation of renal cysts into renal cell carcinoma. (medscape.com)
  • Because VHL disease is a multiple-organ disease that widely varies in clinical presentation, various manifestations may lead to diagnosis. (medscape.com)
  • Depending on the type and force of injury, bones may fracture in various ways - lengthwise, crosswise, or into two or more pieces. (medicalnewstoday.com)
  • 65 years), and older age groups (≥65 years) or by baseline bone mineral density and fracture risk? (uspreventiveservicestaskforce.org)
  • Low vitamin K status is associated with decreased bone mineral density and increased risk of fracture. (lifeextension.com)
  • Any increased physiological function, such as a fracture in the bone, will usually mean increased concentration of the tracer. (wikipedia.org)
  • If your bone density is low or you have had a fracture, you may benefit from medical treatment and/or future monitoring with bone density tests. (massgeneral.org)
  • Since general risk factors and HIV-related factors affect both bone turnover and BMD, the aim of our study was to assess the prevalence of low BMD in HIV-infected subjects and controls and to analyze the effects of calcium intake and other environmental risk factors in order to increase current interest in the management of bone disease in the HIV-population through appropriate dietary and lifestyle interventions. (biomedcentral.com)
  • Bone has so far been perceived as an inert structure needed for mobility, calcium homeostasis and maintenance of hematopoietic tissue. (com.hr)
  • Vitamin D and calcium are commonly recommended for bone health. (lifeextension.com)
  • Vitamin D triggers the absorption of calcium and deposition in bone, where calcium provides hardness. (lifeextension.com)
  • The addition of silica to a calcium and vitamin D regimen improved production of bone proteins. (lifeextension.com)
  • A collagen calcium chelate was developed and has been shown to improve bone mineral density and femur bone strength. (lifeextension.com)
  • The omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may reduce activity of bone-resorbing cells, increase that of bone-forming cells, and improve calcium balance. (lifeextension.com)
  • Vitamin D is a well-known central regulator of bone and calcium metabolism. (termedia.pl)
  • RÉSUMÉ Le présent essai clinique randomisé, en double aveugle, contrôlé contre placebo, a évalué l'effet de la supplémentation en zinc sur les taux de zinc et de calcium sériques chez des femmes ostéoporotiques ménopausées. (who.int)
  • Les mesures anthropométriques, l'apport alimentaire en zinc et en calcium, les taux de zinc et de calcium sériques ont été évalués au début de l'étude puis à 60 jours. (who.int)
  • Les concentrations moyennes initiales en zinc sérique étaient nettement inférieures aux valeurs normales, mais les taux de calcium sérique moyens étaient normaux. (who.int)
  • BACKGROUND: The VDR protein is at the centre of the vitamin D endocrine system, a complex physiological system with substantial feedback regulatory mechanisms involved in maintaining serum calcium and 1, 25 dihydroxy vitamin D3. (who.int)
  • Calcium is a mineral that keeps your bones and teeth healthy and strong. (healthpediaindia.com)
  • Most of the patients with primary HPT are diagnosed because of asymptomatic hypercalcemia, and both signs and symptoms of the disease, when present, are nonspecific, mainly depending on serum calcium concentration. (eurekaselect.com)
  • Paget disease of bone is a disorder that causes bones to grow larger and weaker than normal. (medlineplus.gov)
  • The pediatric endocrinologists at Penn State Health Children's Hospital know that learning your child has an endocrine disorder can be overwhelming, and we're here to help. (pennstatehealth.org)
  • We're committed to providing experienced, advanced diabetes and endocrine disorder treatment to children and adolescents all throughout Pennsylvania. (pennstatehealth.org)
  • Although it is a very rare disorder, study of this and other bone marrow failure syndromes has improved scientific understanding of the mechanisms of normal bone marrow function and development of cancer. (wikipedia.org)
  • [3] The disease is named after the Swiss pediatrician who originally described this disorder, Guido Fanconi . (wikipedia.org)
  • The disorder has no known cause, however a veterinarian's examination is important to determine the general health of the pet and to ensure that there is no underlying disease that may be causing the seizures. (pediamaster.com)
  • von Hippel-Lindau (VHL) disease, or von Hippel-Lindau syndrome, is a rare genetic disorder characterized by visceral cysts and benign tumors in multiple organ systems that have subsequent potential for malignant change. (medscape.com)
  • COVID-19 is the third coronavirus infection and fatalities due to COVID-19, underlying comorbidities that has spread widely, after SARS and Middle East such as cardiovascular diseases and immune deficiency, respiratory syndrome (MERS). (who.int)
  • In his book "History of Selenium", Richard Morrill takes a closer look at some of the studies that link improved selenium status to lower cancer rates and fewer cardiovascular diseases. (pharmanord.com)
  • It is linked to Kidney damage, liver disease, dermatitis, and can damage cell membranes. (15mlliving.com)
  • Alanine aminotransferase measurements are used in the diagnosis and treatment of certain liver diseases (e.g., viral hepatitis and cirrhosis) and heart diseases. (cdc.gov)
  • Serum elevations of ALT activity are rarely observed except in parenchymal liver disease, since ALT is a more liver-specific enzyme than aspartate aminotransferase (AST). (cdc.gov)
  • Albumin measurements are used in the diagnosis and treatment of numerous diseases primarily involving the liver or kidneys. (cdc.gov)
  • Increased ALP activity is associated with two groups of diseases: those affecting liver function and those involving osteoblastic activity in the bones. (cdc.gov)
  • AST measurements are used in the diagnosis and treatment of certain types of liver and heart disease. (cdc.gov)
  • It is currently the most sensitive enzymatic indicator of liver disease, with normal values rarely found in the presence of hepatic disease. (cdc.gov)
  • Take care of your liver…reduce alcohol and eat quality protein - Since the liver breaks down estrogen, alcohol consumption, drug use, liver disease, and any other factor that impairs healthy liver function can spur an estrogen build-up. (prometaboliclife.com)
  • Other causes include previous cancer treatment with anticancer drugs, or radiation treatment, and Paget's disease of bone . (medicalnewstoday.com)
  • Biopharmaceutical companies can use it to develop drugs that cure a disease or manage its symptoms. (medlineplus.gov)
  • Finally, sometimes dogs that are on long-term drugs like prednisolone and dexamethasone (both similar to cortisol) can sometimes show Cushing's-like symptoms if the dose is too high (iatrogenic Cushing's disease). (vethelpdirect.com)
  • The Association of Racing Commissioners International (ARCI) is formally calling for the independent regulation of the breeding and sales industries, including regulation of the class of drugs known as bisphosphonates, which are approved by the US Food and Drug Administration (FDA) for the treatment of navicular disease. (blogspot.com)
  • Steroids are usually the first choice of therapy for the treatment of patients with graft-vs.-host disease (GVHD), but complications from steroid use may carry a high financial cost, investigators caution. (medscape.com)
  • Overall, 22% of patients had only acute GVHD, 21% had only chronic GVHD, and 39% had both acute and chronic disease. (medscape.com)
  • The median time from GVHD diagnosis to initiating steroids was 30 days for patients with both acute and chronic disease, as well as those with both presentations. (medscape.com)
  • Among all patients with complications, the median cumulative hospital stay over 24 months was 20 days, with bone/muscle complications and infections associated with a median of 19 and 18 days of hospitalization, respectively. (medscape.com)
  • Osteolytic bone disease is the hallmark of multiple myeloma, which deteriorates the quality of life of myeloma patients, and it affects dramatically their morbidity and mortality. (nature.com)
  • up to 80% of patients present with osteolytic bone lesions at diagnosis and have an increased risk of skeletal-related events (SREs) associated with increased morbidity and mortality 1 . (nature.com)
  • Zolendronic acid is combined with novel anti-myeloma agents and reduces SREs, improves quality of life, while it prolongs both disease-free and overall survival at least in subsets of MM patients. (nature.com)
  • Understanding of the underlying pathogenetic mechanisms of bone destruction is crucial for the effective management and the improvement of quality of life of MM patients. (nature.com)
  • Thus, the aim of this review is to provide a clear insight into the underlying pathogenesis of bone disease in MM patients. (nature.com)
  • In one study of β-thalassemia major, for patients in whom more than 67% of ferritin measurements exceeded 2500 ng/mL, the estimated disease-free survival was 38% after 10 years of therapy and 18% after 15 years. (medscape.com)
  • Celiac disease may occur at a higher frequency in patients with CF than the general population, and symptoms of these conditions may overlap. (hindawi.com)
  • We report on two patients presenting with CF-related bone disease in the past year who were subsequently found to have concurrent celiac disease. (hindawi.com)
  • Because adherence to a gluten-free diet may improve BMD in patients with celiac disease, this could have important implications for treatment. (hindawi.com)
  • Clinicians should consider screening for celiac disease in patients with CF who have low BMD, worsening BMD in the absence of other risk factors, and/or difficult to treat vitamin D deficiency. (hindawi.com)
  • As patients with CF live longer, endocrine complications such as CF-related bone disease are becoming increasingly prevalent. (hindawi.com)
  • The symptoms of celiac disease may be difficult to distinguish from those related to CF, particularly in patients with malabsorption from pancreatic insufficiency. (hindawi.com)
  • ABSTRACT The aim of this study was to describe the oral health, general health status and medication use of elderly dental patients 709 voluntary patients, aged 60 years and over, who attended Suleyman Demirel University Faculty of Dentistry for routine dental treatment between March 2008 and April 2009 in Isparta, Turkey, were interviewed for demographic data, systemic diseases, and lists of medications. (who.int)
  • 709 patients volontaires, âgés de 60 ans et plus, qui avaient consulté à la Faculté de Dentisterie de l'Université de Suleyman Demirel pour des soins dentaires de routine entre mars 2008 et avril 2009 à Isparta, en Turquie, ont été interrogés pour obtenir des données démographiques, ainsi qu'au sujet des maladies systémiques et des listes de médicaments qui les concernaient. (who.int)
  • Some patients require bone grafting. (ucihealth.org)
  • Celiac Disease (CD) occurs in patients with Type 1 Diabetes (T1D) ranging the prevalence of 4.4-11.1% versus 0.5% of the general population. (springer.com)
  • Some authors hypothized that in genetically susceptible patients one disease could predispose to another. (springer.com)
  • Dublin, Ireland - March 20, 2018 - Shire plc (LSE: SHP, NASDAQ: SHPG), the global leader in rare diseases, announced new data on its recombinant human parathyroid hormone (1-84) (rhPTH[1-84]) in patients with chronic hypoparathyroidism, at the Endocrine Society's 100th Annual Meeting and Exposition (ENDO), in Chicago, Illinois. (takeda.com)
  • The new data we are presenting at ENDO demonstrates a step forward in our understanding of chronic hypoparathyroidism, providing us with new insights into the burden of illness and how it may impact patients living with this rare disease," said Howard Mayer M.D., Senior Vice President and Chief Medical Officer, Shire. (takeda.com)
  • Presentations at ENDO focused on research into the renal function of patients with chronic hypoparathyroidism 4 , the impact of the disease on quality of life 5 , as well as an analysis of the long-term safety and efficacy of rhPTH(1-84), the RACE study 6 . (takeda.com)
  • We have shown that patients considered controlled by SA don t suppress serum GH during OGTT and have impaired disease-specific QoL as compared to patients controlled by surgery. (endocrine-abstracts.org)
  • Most medical insurance companies cover bone density testing for patients with certain medical conditions, though many insurers limit the frequency of these tests. (massgeneral.org)
  • We provide care for patients with complex endocrine and diabetes-related conditions, of which can include, renal, advanced stage diabetes foot and cardiovascular complications. (uhcw.nhs.uk)
  • We recommend that plain radiographs be obtained of the pertinent regions of the skeleton in patients with suspected Paget's disease. (bvsalud.org)
  • After diagnosis of Paget's disease, we recommend measurement of serum total alkaline phosphatase or, when warranted, a more specific marker of bone formation or bone resorption to assess the response to treatment or evolution of the disease in untreated patients. (bvsalud.org)
  • We suggest treatment with a bisphosphonate for most patients with active Paget's disease who are at risk for future complications. (bvsalud.org)
  • In patients with monostotic disease who have a normal serum total alkaline phosphatase, we suggest that a specific marker of bone formation and bone resorption be measured, although these may still be normal. (bvsalud.org)
  • Dr di Leo noted that most patients in these trials had previously benefited from a prior round of endocrine therapy, while the remainder were endocrine therapy naive. (medscape.com)
  • patients with sclerotic/osteoblastic bone lesions only in the absence of measurable disease are not eligible. (who.int)
  • Bone age was delayed in 12 patients. (bvsalud.org)
  • Arsenic-associated diseases typically have a long latency period, so that many patients exposed to arsenic are asymptomatic for years. (cdc.gov)
  • Notably, the topline results were also positive for the ESR1 mutation sub segment, an important driver of resistance to endocrine therapy in ER+/HER2- mBC patients," Ergun added. (hotprofitsclub.com)
  • Additional therapeutic options for this patient population are urgently needed…The trial results being statistically significant demonstrate a clinically meaningful improvement of PFS in the elacestrant group versus endocrine standard of care in patients previously treated with endocrine therapies and CDK 4/6 inhibitors…It was also important to see the positive data for those patients with ESR1 mutations, known to confer additional resistance to standard endocrine therapy. (hotprofitsclub.com)
  • Inhibiting AKT with MK-2206 or MEK1/2 with U0126 for 24 hours in the absence of R5020 increased total and nuclear PRA and PRB protein levels in OSIS but not in eutopic endometrial stromal cells from disease-free patients from disease-free patients. (webpediatrica.com)
  • The image below illustrates a hemangioblastoma of the retina as found in patients with VHL disease. (medscape.com)
  • [ 2 ] Diagnosed in 50% of patients with VHL disease, these hemangiomas are composed of endothelial cells and pericytes. (medscape.com)
  • Tumors involving other organs and the CNS (brain, spinal cord) are present in 25% of patients with VHL disease. (medscape.com)
  • The unexpected finding of a retinal or CNS hemangioblastoma or the diagnosis of a pheochromocytoma should prompt a search for other associated VHL disease features, as many of these patients may have the diagnostic criteria for VHL disease. (medscape.com)
  • Acromegaly is the result if the disease mechanism starts after puberty. (nftartranking.com)
  • An influence of metabolism , hormone, the properties of bone, dietary life, nutrition, and living and social environment makes differences on growth and development of children. (slideserve.com)
  • Recent research on genetically manipulated mice demonstrated the importance of the bone not only as a structural support for the human body, but as a regulator of various metabolic processes that are independent of mineral metabolism. (com.hr)
  • Phthalates are endocrine disruptors and come with a similarly long list of risks: they've been linked with asthma, ADHD, breast cancer, obesity, type II diabetes, low IQ, neurodevelopmental issues, behavioral issues, and altered reproductive development. (convio.net)
  • Let's not forget that many of these chemicals, like phthalates and PFAS, are endocrine disruptors that experts believe are causing a fertility crisis in which sperm counts are plummeting and penis size is shrinking. (convio.net)
  • Toradol(sp) for pain which endocrine disruptors and disrupt nightlife travel tips and. (dridiesel.com)
  • Disturbingly, at least nine of the sunscreen ingredients the U.S. Food and Drug Administration (FDA) has approved are known endocrine disruptors. (skinorganics.life)
  • She completed adjuvant chemotherapy and adjuvant radiation therapy and started endocrine therapy, which she has continued to receive up until her presentation. (medscape.com)
  • Osteomas are slow-developing, usually benign tumors formed by the abnormal growth of bone and other tissue that grows next to or within bones, including the skull and facial bones. (ucihealth.org)
  • Transcriptome profiling of rat PCC identified Bmp7 (bone morphogenetic protein 7) as highly expressed in the tumors. (endocrine-abstracts.org)
  • FA is characterized by bone marrow failure, AML , solid tumors, and developmental abnormalities. (wikipedia.org)
  • The location of tooth root infections, the extent of periodontal bone loss and the identification of bone cysts and tumors can be identified using dental x-rays. (vcahospitals.com)
  • Coeliac disease and primary hyperparathyroidism: an association? (bmj.com)
  • An increase in serum phosphatase activity is associated with primary hyperparathyroidism, secondary hyperparathyroidism owing to chronic renal disease, rickets, and osteitis deformans juvenilia due to vitamin D deficiency and malabsorption or renal tubular dystrophies. (cdc.gov)
  • Multiple myeloma (MM) is a plasma cell dyscrasia characterized by malignant proliferation of monoclonal plasma cells in the bone marrow. (nature.com)
  • From spark-coils to oscillating-current electrical components motorcycles can generate excessive ELF EMF magnetic radiations flooding the rider's gastrointestinal (GIT) melatonin and bone marrow melatonin. (scribd.com)
  • Bone marrow melatonin is crucial for immune system defense against pathogens, disease and cancer. (scribd.com)
  • Treatment with androgens and hematopoietic (blood cell) growth factors can help bone marrow failure temporarily, but the long-term treatment is bone marrow transplant if a donor is available. (wikipedia.org)
  • [6] About 80% of FA will develop bone marrow failure by age 20. (wikipedia.org)
  • Secondary bone deformities and various endocrine anomalies may also be associated. (cdc.gov)
  • Other complications of Paget disease of bone depend on which bones are affected. (medlineplus.gov)
  • and bone or muscle complications (myopathy, etc). (medscape.com)
  • They estimated costs based on International Classification of Diseases (ICD) codes for any steroid complications during the 24 months after steroid initiation, including those complications that may have been present at the time of GVHD diagnosis. (medscape.com)
  • Primary HPT can also occur in familial syndromes, such as multiple endocrine neoplasia type 1 (MEN 1), MEN 2A, hyperparathyroidism-jaw tumor (HPT-JT) syndrome, and familial isolated primary HPT, which seems to be an early stage of MEN 1 or HPT-JT. (eurekaselect.com)
  • A combination of genetic and environmental factors likely play a role in causing Paget disease of bone. (medlineplus.gov)
  • However, the influence of genetic and environmental factors on the development of Paget disease of bone remains unclear. (medlineplus.gov)
  • Mutations in the SQSTM1 gene are the most common genetic cause of classic Paget disease of bone, accounting for 10 to 50 percent of cases that run in families and 5 to 30 percent of cases in which there is no family history of the disease. (medlineplus.gov)
  • Studies suggest that genetic variations in certain regions of chromosome 2, chromosome 5, and chromosome 10 appear to contribute to disease risk. (medlineplus.gov)
  • The mechanism of association of these two diseases involves a shared genetic background: HLA genotype DR3-DQ2 and DR4-DQ8 are strongly associated with T1D, DR3-DQ2 with CD. (springer.com)
  • The majority of autoimmune endocrine diseases, including T1D, are inherited as complex genetic traits. (springer.com)
  • Other less common reasons for impaction include: crowding, endocrine alterations, bone diseases, genetic conditions, extraction or ankylosis of primary incisors. (dentalxp.com)
  • Fanconi anaemia ( FA ) is a rare genetic disease resulting in impaired response to DNA damage. (wikipedia.org)
  • Variations in VDR gene are shown to have implications in several diseases and have also been implicated as an important genetic factor affecting bone mass. (who.int)
  • In this large genome-wide genetic association study using mendelian randomization, HDPs were associated with higher risk of coronary artery disease and ischemic stroke but not heart failure or atrial fibrillation. (cdc.gov)
  • [ 45 ] Inflammation, disseminated malignancy, and chronic diseases can also cause large amounts of ferritin to be released in the circulation, making a single elevated reading unreliable. (medscape.com)
  • Two of the latest theories about the origins of heart disease are chronic inflammation in the arteries and thyroid insufficiency. (westonaprice.org)
  • The fat-soluble vitamins (vitamin A, vitamin D and vitamin K 2 /activator X), which occur in the fat of grass-fed animals, support endocrine function and protect against inflammation. (westonaprice.org)
  • Experts will use new, advanced research tools to discover how these diseases cause problems like inflammation, injury, abnormal function, and illness in the body. (medlineplus.gov)
  • Studies have also shown that testosterone reduces angina pain and lowers levels of CRP - a heart disease risk factor related to inflammation. (sedonaspotlight.com)
  • The company's activities are centered around developing and commercializing therapeutics to address unmet medical needs in the areas of analgesia, cardiology, diabetes, gastroenterology, infectious diseases, inflammation, oncology and pneumology. (hotprofitsclub.com)
  • And because it's responsible for so many essential processes, chronic inflammation and autoimmune disease of the thyroid can have a huge effect on your general health. (dremilyparke.com)
  • First-line treatment for endocrine sensitive bone-only metastatic breast cancer: is more always better? (esmo.org)
  • The standard first-line for endocrine sensitive metastatic breast cancer (BC) is represented by endocrine therapy. (esmo.org)
  • COPENHAGEN - Should a targeted therapy be added to endocrine therapy in the treatment of hormone-dependent metastatic breast cancer? (medscape.com)
  • The question for the debate was whether combined endocrine therapy with targeted agents should now be the standard of care for ER-positive metastatic breast cancer. (medscape.com)
  • The "yes" argument to support the motion that combined endocrine therapy with targeted agents should now be the standard of care for ER-positive metastatic breast cancer was outlined by Angelo di Leo, MD, PhD, head of the Medical Oncology Unit, Department of Oncology, Hospital of Prato, Istituto Toscani Tumori, Prato, Italy. (medscape.com)
  • Bone - an endocrine organ? (com.hr)
  • These advances in research create new perception of the bone, givinig it a role of an endocrine organ which modulates processes from glucose tolerance to bone-specific protein excretion - such as osteocalcin, FGF23, sklerostin, DKK1 and bone morfogenetic proteins. (com.hr)
  • These diseases are associated with organ-specific autoantibodies: AIT with thyroid peroxidase (TPO) and thyroglobulin autoantibodies (TG), CD with endomysial (EMA) and transglutaminase (TTG) autoantibodies, and AD with adrenal autoantibodies. (springer.com)
  • Elevated levels of the transaminases can indicate myocardial infarction, hepatic disease, muscular dystrophy, or organ damage. (cdc.gov)
  • The ovaries no longer have follicles and their function, as a steroidogenic endocrine organ does not work anymore. (bvsalud.org)
  • Treatment includes medicines that slow down bone loss and support bone growth. (medicalnewstoday.com)
  • Surgery is the usual treatment of choice for bone cancer, where the doctor removes the entire tumor. (medicalnewstoday.com)
  • The use of the combination for the first-line treatment of bone-only disease (BoD) is widely discussed. (esmo.org)
  • Recombinant human parathyroid hormone (rhPTH [1-84]) is a relatively new treatment in the management of the disease in its chronic form, and therefore it is important to further improve our understanding of the safety and efficacy profile, especially in longer-term management of the condition. (takeda.com)
  • This course will provide the latest evidence-based information on peri-implant diseases with emphasis on a team/interdisciplinary approach to treatment. (dentalxp.com)
  • Part of the Massachusetts General Hospital Endocrine Unit , the Bone Density Center provides leading-edge bone density testing services to help your primary care physician or specialist develop a treatment program tailored to your needs. (massgeneral.org)
  • Based on your doctor's referral, the Bone Density Center performs one of several tests to determine the causes of your symptoms and provide your primary care physician or specialist with information to help develop a treatment plan. (massgeneral.org)
  • The aim of this guideline was to formulate practice guidelines for the diagnosis and treatment of Paget's disease of the bone. (bvsalud.org)
  • Serial radionuclide bone scans may determine the response to treatment if the markers are normal. (bvsalud.org)
  • We suggest that bisphosphonate treatment may be effective in preventing or slowing the progress of hearing loss and osteoarthritis in joints adjacent to Paget's disease and may reverse paraplegia associated with spinal Paget's disease. (bvsalud.org)
  • We suggest treatment with a bisphosphonate before surgery on pagetic bone. (bvsalud.org)
  • a) Received at least 24 months of AI treatment as part of their adjuvant therapy without disease progression and disease free interval since the last adjuvant treatment must be greater than 12 months (applicable to male, pre/peri- and post-menopausal women). (who.int)
  • b) Received at least 24 months of tamoxifen treatment as part of their adjuvant endocrine therapy if participant is male or premenopausal or peri-menopausal female at study entry. (who.int)
  • Resorption may be inflammatory or by substitution and it can be triggered by traumatism, induced movement of teeth, periapical disease, periodontal treatment and whitening of non-vital teeth. (bvsalud.org)
  • Identifying promising treatment targets for autoimmune diseases can lead to more targeted and effective tools for diagnosing and treating them. (medlineplus.gov)
  • You may learn in this Diseases Treatment Dictionary. (diseasesdic.com)
  • Therefore, the foot massage plays an important method to the body's health, supporting the treatment of many common diseases. (goldenlotusspa.vn)
  • Recently I've been receiving many clients who have chronic health problems that do not respond to any treatment with medications, diet or endocrine enhancing supplements. (cascadehealthconsulting.com)
  • The off leader of this four-horse hitch recovered from a fractured splint bone following treatment at the University of Georgia College of Veterinary Medicine and will be leading the first six-horse hitch to pull the Wells Fargo Stagecoach in the 2018 Rose Bowl Parade in Pasadena, California next weekend. (blogspot.com)
  • On completion, students have a framework of anatomical knowledge on which to build future understanding of disease and treatment. (iu.edu)
  • The wide age range and pleiotropic manner in which VHL disease presents complicates diagnosis and treatment in affected individuals, as well as their at-risk relatives. (medscape.com)
  • Targeted therapies, based on the better knowledge of the biology, constitute a promising approach in the management of myeloma-related bone disease and several novel agents are currently under investigation. (nature.com)
  • The therapeutic strategy of MM-induced bone disease includes a multimodality approach ranging from bisphosphonates and targeted therapies to local irradiation and orthopedic intervention 1 . (nature.com)
  • Chronic kidney disease (CKD) has emerged as a major public health issue in recent years [1]. (termedia.pl)
  • Hypertension, an element of a condition known as metabolic syndrome, is associated with a greater risk of heart attack, heart failure, stroke, kidney disease, vision loss and sexual dysfunction, according to the AHA . (eatthis.com)
  • Hypercalcemia may cause renal damage both temporary (alteration of renal tubular function for instance) and persisting (relapsing nephrolithiasis, especially with high kidney stones) by different ways, leading to a progressive loss of renal function, and ultimately the end stage renal disease with subsequent need of renal replacement therapy. (eurekaselect.com)
  • When the new bone tissue grows, it is larger, weaker, and less organized than normal bone. (medlineplus.gov)
  • Screening tests for celiac disease showed a total immunoglobulin A (IgA) of 375 ng/dL (reference range 69-309 mg/dL) and an elevated anti-tissue transglutaminase (TTG) IgA level of 195.09 U/mL (reference range 0-15 U/mL). (hindawi.com)
  • Fibrous dysplasia is a bone disease that destroys and replaces normal bone with fibrous bone tissue. (ucihealth.org)
  • Many people with classic Paget disease of bone do not experience any symptoms associated with their bone abnormalities. (medlineplus.gov)
  • These discoveries can contribute to the development of new treatments for autoimmune diseases by revealing new clues about the specific cells, pathways, and processes involved when someone with an autoimmune disease experiences symptoms such as pain, swelling, and stiffness. (medlineplus.gov)
  • We will discuss the types of Cushing's disease , its symptoms, and how we diagnose and treat it. (vethelpdirect.com)
  • To know any Diseases that which may it causes, symptoms on your body, and how can prevent from them, what to do on first aid, Definition's, Diagnosis and Test, Risk Factors, specific treatments. (diseasesdic.com)
  • The instructor will present research findings on peri-implant disease diagnosis and management. (dentalxp.com)
  • If the diagnosis is confirmed, we suggest that a radionucleotide bone scan be done to determine the extent of the disease. (bvsalud.org)
  • BUN measurements are used in the diagnosis of certain renal and metabolic diseases. (cdc.gov)
  • Dr. Ranganath Muniyappa , Program Director, studies of the metabolic and vascular actions of insulin and how these actions are impaired in insulin-resistant states such as obesity, diabetes, and cardiovascular disease. (nih.gov)
  • Mature osteoclasts bind tightly to the bone and create a sealed microenvironment where they produce enzymes that affect the organic matrix, as well as acid that degrades the mineral component. (nature.com)
  • Both cystic fibrosis (CF) and celiac disease can cause low bone mineral density (BMD) and fractures. (hindawi.com)
  • The Bone Density Center played an important role in the development of dual-energy X-ray absorptiometry (DXA), the current standard for measuring bone mineral density. (massgeneral.org)
  • To analyze the relationship between age, body mass index (BMI), bone mineral density (BMD), and alveolar bone resorption with menopause duration in postmenopausal women. (bvsalud.org)
  • To build on this work, in 2021, AMP launched the Accelerating Medicines Partnership® Autoimmune and Immune-Mediated Diseases (AMP® AIM) program. (medlineplus.gov)
  • Physiological bone remodeling is the result of the harmonious coupling of bone resorption and bone formation. (nature.com)
  • Several isoflavones have been shown in animal models to contribute to increased bone mineralization and strength, while reducing bone resorption. (lifeextension.com)
  • Supplementation has been shown to reduce bone turnover, favoring bone formation over resorption. (lifeextension.com)
  • Categorical determinations of age, BMI, BMD, and alveolar bone resorption were based on receiver operating characteristic (ROC) curves. (bvsalud.org)
  • The longer the duration of menopause showed a tendency for lower bone density and higher age, BMI, and bone resorption. (bvsalud.org)
  • The longer the duration of menopause, the more estradiol function decreases, which causes osteoclasts to become active in bone resorption [3]. (bvsalud.org)
  • When their protective barriers are missing, hormones and cells that are present during inflammatory processes induce activation of clasts which, when unbalanced, no longer perform physiological bone remodeling and begin to provoke an immunopathological response that causes dental resorption. (bvsalud.org)
  • You can read a lot of articles on this site about the risks and possible adverse effects of vaccinating your dog … from autoimmune disease or cancers to seizures, thyroid disease, allergies, digestive issues and even death. (dogsnaturallymagazine.com)
  • Controls were selected from cancers not known to be associated with solvent exposure and included 270 skin cancers, 71 mesotheliomas, and 32 bone cancers. (cdc.gov)
  • Breast 4 and prostate 5, 6 cancers are just two examples where low vitamin D renders you more vulnerable to more aggressive forms of the disease. (skinorganics.life)
  • Description Neurocysticercosis, the infection caused by the larval form of the tapeworm Taenia solium, is the most common parasitic disease of the central nervous system and the most common cause of acquired epilepsy worldwide. (diseasesdic.com)
  • The ongoing global pandemic of Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has impacted hundreds of millions of people's lives. (nature.com)
  • Dr. Marissa Lightbourne , conducts transitional care research, investigating cardiometabolic and insulin resistance changes in endocrine disease states in children transitioning to adults. (nih.gov)
  • Insulin like growth factor is a molecule formed in the body which acts on the bone epiphyses triggering rapid cell division and bone growth. (nftartranking.com)
  • Prediabetes is a disease that causes a condition and however it is herbal remedies for diabetes in which the next of excessive insulin is increasing. (dox-box.org)
  • Children and adults with CF are at risk for low bone density and fractures due to multiple potential risk factors including vitamin D deficiency, delayed puberty, hypogonadism, pancreatic insufficiency causing malabsorption, compromised nutrition, glucocorticoid use, reduced physical activity, and possibly CF transmembrane conductance regulator (CFTR) dysfunction itself [ 2 , 3 ]. (hindawi.com)
  • Vitamin K . Vitamin K is essential for bone strength. (lifeextension.com)
  • When he plotted these two variables against time on the same graph he found that deaths from heart disease were inversely proportional to the vitamin content in the butter. (westonaprice.org)
  • Heart disease researchers have largely ignored the possible role of vitamin A and D in protecting the heart, probably because these fat-soluble vitamins are found only in the foods they have demonized-animal fats. (westonaprice.org)
  • García-Bailo B, Da Costa LA, Arora P, Karmali M, El-Sohemy A, Badawi A. Plasma Vitamin D and Biomarkers of Cardiometabolic Disease Risk in Adult Canadians, 2007-2009. (cdc.gov)
  • Vitamin D may modulate cardiometabolic disease risk, although the relationship has not been investigated in the general Canadian population. (cdc.gov)
  • The objectives of this study were to examine the association between vitamin D and traditional and novel biomarkers of cardiometabolic disease and to describe the extent of the month-to-month fluctuations of vitamin D in the Canadian population. (cdc.gov)
  • Vitamin D may modulate various metabolic processes and may influence cardiometabolic disease risk in Canadians. (cdc.gov)
  • These findings may have public health implications when recommending vitamin D for the prevention of cardiometabolic disease and related conditions. (cdc.gov)
  • Inadequate vitamin D status has been associated with elevated cardiometabolic disease risk, although results are inconsistent, as evidenced by recent meta-analyses pooling multiple study populations (6-8). (cdc.gov)
  • The possibility that the effects of vitamin D on cardiometabolic disease differ by sex warrants further study. (cdc.gov)
  • Understanding the association between vitamin D and cardiometabolic risk in Canadians may provide a clearer understanding of how this micronutrient modulates cardiometabolic disease and may inform public health strategies to curb the incidence of cardiometabolic disease in Canada and elsewhere. (cdc.gov)
  • There has been growing recognition of the critical extra-skeletal roles for vitamin D including lung disease. (who.int)
  • Vitamin D receptors have been found in almost every type of human cell, from your brain to your bones. (skinorganics.life)
  • Other factors, including infections with certain viruses, may be involved in triggering the disease in people who are at risk. (medlineplus.gov)
  • It treats chest infections such as pneumonia, nasal and throat infections such as sinus infections (sinusitis), skin infections, Lyme disease, and few sexually transmitted infections. (cyno.co.in)
  • certain localized infections - see body system-related chapters infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium [except obstetrical tetanus] (O98. (who.int)
  • Soy phytoestrogens wreak havoc on the endocrine system, lower thyroid functioning and raise estrogen. (prometaboliclife.com)
  • Beyond testing just testosterone (free and total), estrogen and PSA levels in the blood, we can pick up some very valuable pieces of information about a man's endocrine health and prostate cancer risk with a Testosterone Metabolite test from a specialty lab. (sedonaspotlight.com)
  • The chronic inflammatory state induced by the virus itself may promote bone loss by increasing levels of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), IL-6, IL-1 and NF-kappaB-ligand (RANKL), a member of the TNF superfamily of ligands and receptors [ 1 , 6 ]. (biomedcentral.com)
  • Radiologic study of endosteal, intracortical, and periosteal surfaces of hand bones in metabolic bone diseases. (gentili.net)
  • The final model included sex, age, hypertension, ies in China and Italy suggest that the risk factors for diabetes, heart disease, fever, cough, dyspnoea and severe COVID-19 include underlying comorbidities. (who.int)
  • The use of cardiopulmonary exercise testing (CPET) to indirectly assess mitochondrial and metabolic function as well as to prescribe exercise in populations with chronic diseases. (cuanschutz.edu)
  • [2] It can also diagnose gallbladder diseases , e.g. bile leaks of biliary fistulas . (wikipedia.org)
  • The basis of the pathogenesis of myeloma-related bone disease is the uncoupling of the bone-remodeling process. (nature.com)
  • Herein, we provide an insight into the underlying pathogenesis of bone disease and discuss possible directions for future studies. (nature.com)
  • A key event in the pathogenesis of TSEs is the conversion of the normal cellular prion protein (PrP C , encoded by the PRNP gene) into an abnormal disease-associated isoform (PrP Sc ) in tissues of infected animals. (cdc.gov)
  • Other types of bone cancer may require a combination of treatments that include chemotherapy, radiation, and targeted therapy. (medicalnewstoday.com)
  • Transplantation-related issues such as graft versus host disease, graft failure, chronic immunosuppressive therapy, and transplantation-related mortality should be carefully considered prior to proceeding with this approach. (medscape.com)
  • Because hormones play a major role in bone health, working with a doctor to use bio-identical hormone replacement therapy may help keep bones healthy. (lifeextension.com)
  • Bone density testing is very effective in diagnosing this condition, determining your risk for fractures and monitoring your response to therapy. (massgeneral.org)
  • Glucocorticoid replacement therapy and pharmacogenetics in Addison's disease: effects on bone. (cdc.gov)
  • Before the latest results with combination therapy, it was assumed that they would receive endocrine therapy alone. (medscape.com)
  • 6 Previously untreated with any systemic anti-cancer therapy for their locoregionally recurrent or metastatic ER+ disease. (who.int)
  • Osteonecrosis associated with metabolic disease and corticosteroid therapy. (cdc.gov)
  • Dr. Aditya Bardia, M.D., MPH of the MGH, Associate Professor at the Medicine Department at Harvard Medical School, and Principal Investigator for the EMERALD trial, stated, "Advanced /metastatic ER+/HER2- BC pre-treated with endocrine therapy remains an area of high unmet medical need. (hotprofitsclub.com)
  • The domestic medical screening is a comprehensive medical examination that screens for a wide range of infectious diseases and non-communicable conditions. (cdc.gov)
  • Most migraines last about four hours, which is a collaborative effort between the NYSDOH AI Office of the Medical Director and the Johns Hopkins University School of Medicine, Division of Infectious Diseases. (nnkonforgradnja.com)
  • 4 Up to 14 April 2020, infectious disease caused by severe acute Malaysia has had a total of 4987 infected people and respiratory syndrome coronavirus 2 (SARS-CoV-2). (who.int)
  • carrier or suspected carrier of infectious disease (Z22. (who.int)
  • End-stage renal disease (ESRD) is a major health and economic concern for people all over the world [2]. (termedia.pl)
  • The most frequent are autoimmune thyroid disease (AIT), celiac disease (CD), Addison's disease (AD) and vitiligo. (springer.com)
  • Celiac disease has been associated with compromised bone density in children and adults [ 5 ]. (hindawi.com)
  • A 28-year-old white male with a history of CF (homozygous for the F508del mutation), CF-related diabetes (CFRD), and pancreatic insufficiency presented for evaluation of low bone density. (hindawi.com)
  • The patient reported no significant oral or inhaled glucocorticoid use, delayed puberty, tobacco or alcohol use, or other risk factors for low bone density. (hindawi.com)
  • Those at increased risk may undergo a comprehensive risk assessment, including bone density measurement. (uspreventiveservicestaskforce.org)
  • A doctor can test for bone density. (lifeextension.com)
  • The standard test for men, women and children measures bone density of the spine and hip. (massgeneral.org)
  • In certain cases, we may also run tests to identify any fractures in your spine or to measure the bone density of your forearm or whole body. (massgeneral.org)
  • Bone density scans should not be performed for one week following any barium examination (such as barium swallow, GI series, barium enema, abdominal CT) or nuclear examination. (massgeneral.org)
  • Our standard reports include measurement of your bone density and how it has changed over time. (massgeneral.org)
  • Your bone density reports are available to your doctor within 3 to 5 business days and include general recommendations for medical management. (massgeneral.org)
  • If your bone density is normal, you may not need further testing for years. (massgeneral.org)
  • Founded in 1976, the Massachusetts General Hospital Bone Density Center was the first center of its kind in the eastern United States. (massgeneral.org)
  • Less visible or noticeable, bone density can drop - leaving older men at risk for fractures. (sedonaspotlight.com)
  • Restoring normal testosterone levels has been shown to improve bone density - especially important for men over 60. (sedonaspotlight.com)
  • Benign sporadic primary HPT is caused by a solitary adenoma in 80-85%, by multiglandular disease (multiple adenoma, parathyroid hyperplasia) in 12-14%, and parathyroid carcinoma in 1-2% of the cases. (eurekaselect.com)
  • Its features are similar to those of the classic form of the disease, although it is more likely to affect the skull, spine, and ribs (the axial skeleton) and the small bones of the hands. (medlineplus.gov)
  • Bone remodeling constitutes a dynamic lifelong process in adults that is vital for the skeleton in order to sustain the mechanical load. (nature.com)
  • Radiology of the skeleton in endocrine diseases. (gentili.net)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • Saving Lives, Protecting People Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • According to the Centers for Disease Control: 'HGH was found to accumulate in the plasma of non-anabolic androgenic steroid users at rates of 10%-25% higher than that of non-users, deca durabolin 250. (noahsarkctcf.com)
  • This photograph was one of a series of images highlighting the Native American Diabetes Wellness Program's Eagle Books Exhibit at the Centers for Disease Control and Prevention's (CDC) Public Health Library and Information Center (PHLIC). (cdc.gov)
  • Growth hormone acts on the bone epiphysis triggering bone growth. (nftartranking.com)

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