Diseases of BONES.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Ductless glands that secrete HORMONES directly into the BLOOD CIRCULATION. These hormones influence the METABOLISM and other functions of cells in the body.
Bone loss due to osteoclastic activity.
The system of glands that release their secretions (hormones) directly into the circulatory system. In addition to the ENDOCRINE GLANDS, included are the CHROMAFFIN SYSTEM and the NEUROSECRETORY SYSTEMS.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.
Tumors or cancer located in bone tissue or specific BONES.
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.
Pathological processes of the ENDOCRINE GLANDS, and diseases resulting from abnormal level of available HORMONES.
Tumors or cancer of the ENDOCRINE GLANDS.
Exogenous agents, synthetic and naturally occurring, which are capable of disrupting the functions of the ENDOCRINE SYSTEM including the maintenance of HOMEOSTASIS and the regulation of developmental processes. Endocrine disruptors are compounds that can mimic HORMONES, or enhance or block the binding of hormones to their receptors, or otherwise lead to activating or inhibiting the endocrine signaling pathways and hormone metabolism.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Dissolution of bone that particularly involves the removal or loss of calcium.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
Breaks in bones.
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.
Syndromes of bone destruction where the cause is not obvious such as neoplasia, infection, or trauma. The destruction follows various patterns: massive (Gorham disease), multicentric (HAJDU-CHENEY SYNDROME), or carpal/tarsal.
The process of bone formation. Histogenesis of bone including ossification.
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.
Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
The largest of three bones that make up each half of the pelvic girdle.
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.
A VITAMIN D that can be regarded as a reduction product of vitamin D2.
A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)
The grafting of bone from a donor site to a recipient site.
Diseases of the bones related to hyperfunction or hypofunction of the endocrine glands.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.
A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are MEN1 and MEN2 with gene mutations on CHROMOSOME 11 and CHROMOSOME 10, respectively.
A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.
Abnormally high level of calcium in the blood.
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Stable strontium atoms that have the same atomic number as the element strontium, but differ in the atomic weight. Sr-84, 86, 87, and 88 are the stable strontium isotopes.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).
Death of a bone or part of a bone, either atraumatic or posttraumatic.
A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.
A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.
Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.
A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.
A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher.
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
An abnormal hardening or increased density of bone tissue.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.
Tumors or cancer of the human BREAST.
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.
Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.
Bone diseases caused by pathogenic microorganisms.
COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Cells found throughout the lining of the GASTROINTESTINAL TRACT that contain and secrete regulatory PEPTIDE HORMONES and/or BIOGENIC AMINES.
Inorganic compounds that contain TECHNETIUM as an integral part of the molecule. Technetium 99m (m=metastable) is an isotope of technetium that has a half-life of about 6 hours. Technetium 99, which has a half-life of 210,000 years, is a decay product of technetium 99m.
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.
Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
Elements of limited time intervals, contributing to particular results or situations.
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
Excision of one or more of the parathyroid glands.
Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
Inorganic salts of phosphoric acid.
Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.
A coronary vasodilator agent.
A circular structural unit of bone tissue. It consists of a central hole, the Haversian canal through which blood vessels run, surrounded by concentric rings, called lamellae.
Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.
A condition of an abnormally low level of PHOSPHATES in the blood.
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
Formation of stones in the KIDNEY.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
AMINO ACIDS composed of GLYCINE substituted at the nitrogen rather than the usual carbon position, resulting in the loss of HYDROGEN BONDING donors. Polymers of these compounds are called PEPTOIDS.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.
A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia.
The spinal or vertebral column.
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.
The bone that forms the frontal aspect of the skull. Its flat part forms the forehead, articulating inferiorly with the NASAL BONE and the CHEEK BONE on each side of the face.
Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
One of the SELECTIVE ESTROGEN RECEPTOR MODULATORS with tissue-specific activities. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.
A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.
Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.
A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.
Pathologic deposition of calcium salts in tissues.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Local surroundings with which cells interact by processing various chemical and physical signals, and by contributing their own effects to this environment.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The surgical removal of one or both ovaries.
Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.
A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.
A benign tumor of the pancreatic ISLET CELLS. Usually it involves the INSULIN-producing PANCREATIC BETA CELLS, as in INSULINOMA, resulting in HYPERINSULINISM.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
Surgery performed on any endocrine gland.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
The bones of the free part of the lower extremity in humans and of any of the four extremities in animals. It includes the FEMUR; PATELLA; TIBIA; and FIBULA.
Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.
A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
Tumors or cancer of the PROSTATE.
Removal of bone marrow and evaluation of its histologic picture.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Fractures of the femur.
A GASTRIN-secreting neuroendocrine tumor of the non-beta ISLET CELLS, the GASTRIN-SECRETING CELLS. This type of tumor is primarily located in the PANCREAS or the DUODENUM. Majority of gastrinomas are malignant. They metastasize to the LIVER; LYMPH NODES; and BONE but rarely elsewhere. The presence of gastrinoma is one of three requirements to be met for identification of ZOLLINGER-ELLISON SYNDROME, which sometimes occurs in families with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; (MEN 1).
The five cylindrical bones of the METACARPUS, articulating with the CARPAL BONES proximally and the PHALANGES OF FINGERS distally.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A group of acidic proteins that are major components of SECRETORY GRANULES in the endocrine and neuroendocrine cells. They play important roles in the aggregation, packaging, sorting, and processing of secretory protein prior to secretion. They are cleaved to release biologically active peptides. There are various types of granins, usually classified by their sources.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Inorganic or organic compounds that contain the basic structure RB(OH)2.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
The giving of drugs, chemicals, or other substances by mouth.
A cell line derived from cultured tumor cells.
An almost always malignant GLUCAGON-secreting tumor derived from the PANCREATIC ALPHA CELLS. It is characterized by a distinctive migratory ERYTHEMA; WEIGHT LOSS; STOMATITIS; GLOSSITIS; DIABETES MELLITUS; hypoaminoacidemia; and normochromic normocytic ANEMIA.
The five long bones of the METATARSUS, articulating with the TARSAL BONES proximally and the PHALANGES OF TOES distally.
The seven bones which form the tarsus - namely, CALCANEUS; TALUS; cuboid, navicular, and the internal, middle, and external cuneiforms.
CCR receptors with specificity for a broad variety of CC CHEMOKINES. They are expressed at high levels in MONOCYTES; tissue MACROPHAGES; NEUTROPHILS; and EOSINOPHILS.
A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)
Cholecalciferols substituted with two hydroxy groups in any position.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
Tumors or cancer of the ADRENAL GLANDS.
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Peptide hormones secreted into the blood by cells in the ISLETS OF LANGERHANS of the pancreas. The alpha cells secrete glucagon; the beta cells secrete insulin; the delta cells secrete somatostatin; and the PP cells secrete pancreatic polypeptide.

Vitamin D receptor activators can protect against vascular calcification. (1/1)

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Shunmugavel, S., Tosi, I., H. Rasmussen, K., E. Jensen, R., Taarning, E., Meier, S. & Riisager, A., 2016. 1 p.. Research output: Contribution to conference › Conference abstract for conference › Research › peer-review ...
Rosen CJ (2008-11-18). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. John Wiley and Sons. pp. 168 ... September 2007). "Bone metastases of differentiated thyroid cancer: impact of early 131I-based detection on outcome". Endocrine ... Bone[edit]. Main article: Bone scintigraphy. For example, the ligand methylene-diphosphonate (MDP) can be preferentially taken ... By chemically attaching technetium-99m to MDP, radioactivity can be transported and attached to bone via the hydroxyapatite for ...
Molecular Genetics of Endocrine Disorders, and Genetics of Bone Biology and Skeletal Disease. Thakker was elected a Fellow of ... Thakker, R. V; Whyte, Michael P; Eisman, John; Igarashi, Takashi (2013). Genetics of Bone Biology and Skeletal Disease. ISBN ... Genetic and Molecular Biological Aspects of Endocrine Disease. ISBN 9780702019456. Thakker, R. (4 September 1998). Molecular ... Thakker has edited several books including Genetic and Molecular Biological Aspects of Endocrine Disease, ...
Encyclopedia of Endocrine Diseases. Academic Press. 2018. p. 344. ISBN 9780128122006. "Office of Dietary Supplements - Vitamin ... Bringhurst F, Demay MB, Krane SM, Kronenberg HM (2008). "Bone and Mineral Metabolism in Health and Disease". In Fauci AS, ... Stimulating release of calcium from bone. For this it acts on the specific type of bone cells referred to as osteoblasts, ... It can be given as a medication for the treatment of low blood calcium and hyperparathyroidism due to kidney disease, low blood ...
"Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases". Endocrine Reviews. 33 (5): 747-83. doi:10.1210/er.2011-1060 ... McCarthy HS, Marshall MJ (February 2010). "Dickkopf-1 as a potential therapeutic target in Paget's disease of bone". Expert ... Elevated levels of DKK1 in bone marrow, plasma and peripheral blood is associated with the presence of osteolytic bone lesions ... Alzheimer's disease occurs due to the overproduction of β-amyloid peptide (βAP) that will cluster together to form plaques ...
... may also lead to muscle weakness in the upper back and to arthritis and other bone-degeneration diseases.[4] ... Camptocormia can lead to infection, tumors, and diseases of the endocrine system and connective tissues. The success of the ... BSS often appears in individuals afflicted with Parkinson's disease, muscular dystrophies, endocrine disorders, inflammatory ... and inflammatory muscle diseases; metabolic or endocrine disorders; and mitochondrial myopathies.[2] A muscle biopsy can ...
Physical effects of malformed bones vary according to the specific disease. Many involve joint pain caused by abnormal bone ... Forms of dwarfism associated with the endocrine system may be treated using hormonal therapy. If the cause is prepubescent ... bones of the upper arm or thigh mesomelic = middle, i.e., bones of the forearm or lower leg acromelic = end, i.e., bones of ... Bone X-rays are often key to diagnosing a specific skeletal dysplasia, but are not the sole diagnostic tool. Most children with ...
... a major risk-factor for veno-occlusive disease in the liver after allogeneic bone marrow transplantation". Blood. 92 (12): 4568 ... Jeffrey K. Aronson (21 February 2009). Meyler's Side Effects of Endocrine and Metabolic Drugs. Elsevier. pp. 217, 253, 275. ... High-dose (10 mg/day) norethisterone has been associated with hepatic veno-occlusive disease, and because of this adverse ... Reviews in Endocrine and Metabolic Disorders. 3 (3): 211-224. doi:10.1023/A:1020072325818. ISSN 1389-9155. PMID 12215716.. ...
Physical effects of malformed bones vary according to the specific disease. Many involve joint pain caused by abnormal bone ... Forms of dwarfism associated with the endocrine system may be treated using hormonal therapy. If the cause is prepubescent ... Those with bone growth disorders can sometimes be treated with surgery, or physical therapy. Hormone disorders can also be ... "Dwarfism and Bone Dysplasias". Seattle Children's Hospital, Research & Foundation. Archived from the original on 2007-05-04. ...
... is a complex genetic disorder affecting the bone, skin and endocrine systems. It is a mosaic disease ... In other cases, children are diagnosed in early infancy, show obvious bone disease, and obvious increased endocrine secretions ... "Age-Related Changes and Effects of Bisphosphonates on Bone Turnover and Disease Progression in Fibrous Dysplasia of Bone". ... Hyperfunctioning endocrine disease Patients may have one or many of these features, which may occur in any combination. As such ...
He has served as the President of the American Society for Bone and Mineral Research and the Endocrine Society. He was a member ... of the Board of Advisors of the Rolanette and Berdon Lawrence Bone Disease Program of Texas from 2006-2012. http://www. ... and studies that identified a role for parathyroid hormone in the regulation of the bone marrow stem cell niche. ... mouse models to understand the role of parathyroid hormone and parathyroid hormone-related protein in the regulation of bone ...
"KDIGO Guideline for Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)". Archived from the original on 4 March 2017. ... Endocrine and Metabolic Disorders - Merck Manuals Professional Edition". Merck Manuals Professional Edition. Merck Sharp & ... metabolism such as hyperphosphatemia are included in the definition of the new chronic kidney disease-mineral and bone disorder ...
... endocrine, and neuropsychological outcome of hematopoietic cell transplantation for Wolman disease". Bone Marrow ... The disease is often undiagnosed in adults. The person may have a history of premature cardiac disease or premature stroke. ... also known as bone marrow transplant, to try to prevent the disease from getting worse. Data are sparse but there is a known ... Wolman disease, presenting in infant patients Cholesteryl Ester Storage Disease, presenting in pediatric and adult patients ...
... a major risk-factor for veno-occlusive disease in the liver after allogeneic bone marrow transplantation". Blood. 92 (12): 4568 ... Trabert B, Sherman ME, Kannan N, Stanczyk FZ (April 2020). "Progesterone and Breast Cancer". Endocrine Reviews. 41 (2): 320-344 ... High-dose (10 mg/day) norethisterone has been associated with hepatic veno-occlusive disease, and because of this adverse ... Amory, John K. (2003). "Androgens and Male Contraception". Androgens in Health and Disease: 405-417. doi:10.1007/978-1-59259- ...
"Nuclear Receptors in Bone Physiology and Diseases". Physiological Reviews. 93 (2): 481-523. doi:10.1152/physrev.00008.2012. ... "e.hormone , Endocrine System : Types of Hormones". e.hormone.tulane.edu. Retrieved 2017-04-06. "The Endocrine System". classes. ... Water-soluble hormones come from amino acids and are located and stored in endocrine cells until actually needed. The main two ... Deficiencies in nuclear receptor-mediated pathways play a key role in the development of disease, like osteoporosis. Water- ...
A number of diseases can cause bone pain, including the following: Endocrine, such as hyperparathyroidism, osteoporosis, renal ... that innervate bone tissue leads to the sensation of bone pain. Bone pain originates from both the periosteum and the bone ... and other bone diseases. Thus there are several types of bone pain, each with many potential sources or origins of cause. From ... Paget's disease of bone (also termed osteitis deformans or ambiguously, just Paget's disease). Pain caused by cancer within ...
... a new endocrine organ at the heart of chronic kidney disease and mineral and bone disorders". The Lancet Diabetes & ... leading to low bone turnover or adynamic bone disease. Both high and low bone turnover diseases are currently observed equally ... Bone pain Joint pain Bone deformation Bone fracture The broader concept of chronic kidney disease-mineral and bone disorder ( ... "Adynamic bone disease: from bone to vessels in chronic kidney disease". Seminars in Nephrology. 34 (6): 626-40. doi:10.1016/j. ...
"Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease". Am J Clin ... Holick honored by Endocrine Society". "BUSM professor receives 2011 ACN Communication Media Award". Institute of functional ... Holick made discoveries in the field of vitamin D that have led to novel therapies for metabolic bone diseases, hypocalcemic ... Jenifer McKim (March 13, 2015). "Boston University researcher draws fire for claiming some broken bones caused by rare disease ...
and other metabolic bone diseases. He has published over 400 scholarly articles and has delivered numerous prestigious ... the Gerald D Aurbach Lecture of the US Endocrine Society in 2009, the Wood lecturer, University of Calgary, Calgary, Alberta, ... He is the Director of the Centre for Bone and Periodontal Research and also holds the position of Senior Scientist at the ... He has been Director of the Centre for Advanced Bone and Periodontal Research, as well as Director of the Calcium Research ...
... hormone disruptions from endocrine disruptors, skin alterations, neurotoxicity, kidney damage, liver damage, bone disease, ... emphysema, ovotoxicity, reproductive damage, and many other fatal diseases. The improper disposal of these hazardous wastes ...
McCune-Albright syndrome, a rare genetic endocrine disease affecting the bones and pigmentation of the skin, was described ... He was a resident physician in pediatrics and contagious diseases at Cincinnati General Hospital from 1929-30, and then a ...
Osteoporosis is a type of bone disease characterized by a loss of bone density, mass and architecture that leaves a patient ... Endocrine: Cushingoid features, growth suppression in children, secondary adrenocortical and pituitary unresponsiveness, ... "Osteoporosis Overview , NIH Osteoporosis and Related Bone Diseases National Resource Center". www.bones.nih.gov. Retrieved 2020 ... Exogenous corticosteroids induce osteoporosis by increasing bone resorption and reducing bone formation. Bone loss can be ...
Julie Steenhuysen (2 September 2015). "Regeneron scientists discover key to excess bone growth in rare disease". Reuters. ... Robertson DM, Burger HG, Fuller PJ (March 2004). "Inhibin/activin and ovarian cancer". Endocrine-Related Cancer. Bioscientifica ... a fatal disease that causes muscle and soft tissue to gradually be replaced by bone tissue. This condition is characterized by ... The mutation in ACVR1 causes activin A, which normally acts as an antagonist of the receptor and blocks osteogenesis (bone ...
The Bone and Joint group investigates diseases of the bone, cartilage, tendons, ligaments and joints, with particular research ... ovary and endocrine organs, as well as regulation of normal body growth and bone metabolism. Research Focus Adrenal Lab Bill ... pregnancy and childbirth to cancer and genetics kidney and heart disease pain and neurological disorders diseases of bones and ... which contribute to the morbidity of bone and joint disease in the Australian community Apart from supporting research ...
Bone. Inflammation. .mw-parser-output .nobold{font-weight:normal}. endocrine:. *Osteitis fibrosa cystica *Brown tumor ... Osgood-Schlatter disease causes pain in the front lower part of the knee.[9] This is usually at the ligament-bone junction of ... Osgood-Schlatter Disease. Other names. Apophysitis of the tibial tubercle, Lannelongue's disease,[1] osteochondrosis of the ... Osgood-Schlatter disease (OSD) is inflammation of the patellar ligament at the tibial tuberosity (apophysitis).[3] It is ...
"Paget's disease of bone: an endocrine society clinical practice guideline". The Journal of Clinical Endocrinology and ... and does not spread from bone to bone. Rarely, a bone affected by Paget's disease can transform into a malignant bone cancer. ... Ethel, SS; Roodman, GD (2008). "Paget's disease of bone". In Rosen. Primer on the metabolic bone diseases and disorders of ... Paget's Disease of Bone Overview - NIH Osteoporosis and Related Bone Diseases ~ National Resource Center. ...
Bone. Inflammation. .mw-parser-output .nobold{font-weight:normal}. endocrine:. *Osteitis fibrosa cystica *Brown tumor ... "Kohler Disease". Foot Health 4 Kids. Retrieved 2018-09-04.. *^ a b c d e "Kohler disease , Genetic and Rare Diseases ... Köhler disease (also spelled "Kohler" and referred to in some texts as Kohler disease I)[1] is a rare bone disorder of the foot ... Köhler disease. Other names. Aseptic necrosis of the tarsal bone, Kohler's Disease of the Tarsal Navicular, Osteochondritis of ...
An endocrine bone disease is a bone disease associated with a disorder of the endocrine system. An example is osteitis fibrosa ... which in turn leads to condition that are not desirable such as bone disorders or other endocrine related diseases. Bone ... therefore are associated with the endocrine bone disease. Some common endocrine disorders are hypothyroidism, hyperthyroidism, ... Joplin, GF (1973). "Endocrine bone disease". Proceedings of the Royal Society of Medicine. 66 (5): 447. doi:10.1177/ ...
2003). "Clinical and Endocrine Responses to Pituitary Radiotherapy in Pediatric Cushing's Disease: An Effective Second-Line ... The disease is often diagnosed 3-6 years after the onset of illness.[19] Several studies have shown that Cushing's disease is ... Cases of Cushing's disease are rare, and little epidemiological data is available on the disease. An 18-year study conducted on ... Cushing disease, tertiary or secondary hypercortisolism, tertiary or secondary hypercorticism, Itsenko-Cushing disease[1][2]. ...
This article is about a skin disease common during adolescence. For other acneiform skin diseases, see Acne (disambiguation). ... Nguyen HL, Tollefson MM (August 2017). "Endocrine disorders and hormonal therapy for adolescent acne". Current Opinion in ... and decreased bone mineral density, make its use for male acne impractical in most cases.[114][115][116] Pregnant and lactating ... Disease Primers. 1: 15033. doi:10.1038/nrdp.2015.33. PMID 27227877.. *^ a b "Frequently Asked Questions: Acne" (PDF). U.S. ...
... and endocrine-like processes)) may not naturally subside in diseases marked by chronic inflammation (including cancer). The SP ... "Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow ... SP concentrations cannot yet be used to diagnose disease clinically or gauge disease severity. It is not yet known whether ... Microbial Toxins and Diarrhoeal Disease. Ciba Found. Symp. 112. pp. 139-54. doi:10.1002/9780470720936.ch8. PMID 2861068.. ...
Mandel SJ, Brent GA, Larsen PR (September 1993). "Levothyroxine therapy in patients with thyroid disease". Annals of Internal ... Sherwood, Lauralee (2010). "19 The Peripheral Endocrine Glands". Human Physiology. Brooks/Cole. p. 694. ISBN 978-0-495-39184-5. ... suppression of TSH values below normal values will frequently cause cardiac side-effects and contribute to decreases in bone ... For older people (over 50 years old) and people with known or suspected ischemic heart disease, levothyroxine therapy should ...
Normally, the bone age is the same as the biological age but for some people, it is older. For many people with advanced bone ... Chronic illnesses, malnutrition, endocrine, metabolic disorders or chromosomal anomalies are characterized by proportionate ... chronic kidney disease, being small for gestational age at birth, Prader-Willi syndrome, Wiedemann-Steiner syndrome, or other ... When the cause is unknown, it is called idiopathic short stature.[5] Short stature can also be caused by the bone plates fusing ...
... removal of one-quarter inch of the center of the hyoid bone, closure of the cut ends of the hyoid bone, and placement of a ... Congenital endocrine disorders (Q89.1-Q89.2, 759.1-759.2). Pituitary. *Congenital hypopituitarism. Thyroid. *Thyroid disease ... between the isthmus of the thyroid and the hyoid bone or just above the hyoid bone. A thyroglossal cyst can develop anywhere ... The Sistrunk procedure is the surgical resection of the central portion of the hyoid bone along with a wide core of tissue from ...
... such as Von Hippel-Lindau disease, multiple endocrine neoplasia, and neurofibromatosis type 2 carry a high risk for the ... The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... Hourigan CS (2006). "The molecular basis of coeliac disease". Clin Exp Med (Review). 6 (2): 53-59. doi:10.1007/s10238-006-0095- ... Frappaz D, Mornex F, Saint-Pierre G, Ranchere-Vince D, Jouvet A, Chassagne-Clement C, Thiesse P, Mere P, Deruty R (1999). "Bone ...
Dent's disease. *X-linked nephrogenic diabetes insipidus. Bone/tooth. *AMELX Amelogenesis imperfecta ... Endocrine. *Androgen insensitivity syndrome/Spinal and bulbar muscular atrophy. *KAL1 Kallmann syndrome ... Symptoms of disease are more severe in males, who are generally diagnosed in early childhood. Children afflicted by CLS display ... The prevalence of CLS is uncertain due to the rarity of the disease, but CLS is estimated to affect between 1 in 50,000 and 1 ...
Paterson, Sue (December 17, 2007). Skin Diseases of Exotic Pets. Blackwell Science, Ltd. pp. 74-79. ISBN 9780470752432. .. ... P.J. Bentley (14 March 2013). Endocrines and Osmoregulation: A Comparative Account in Vertebrates. Springer Science & Business ... The new section will however contain cartilage rather than bone, and will never grow to the same length as the original tail. ... Hellebuyck, Tom; Pasmans, Frank; Haesbrouck, Freddy; Martel, An (July 2012). "Dermatological Diseases in Lizards". The ...
The Hanford Thyroid Disease Study, an epidemiologic study of the relationship between estimated exposure doses to radioiodine ... As studies of biological samples (including bone, thyroid glands and other tissues) have been undertaken, it has become ... raising the possibility that endocrine disrupting chemicals like PCBs and dioxins might combine to increase the risks ... Several severe adverse health effects, such as an increased incidence of cancers, thyroid diseases, CNS neoplasms, and possibly ...
... "induces bone formation and increases bone mineral density reducing the risk for osteoporosis and other bone disorders" pursuant ... Endocrine Reviews: 397-428. doi:10.1210/edrv.19.4.0341.. *^ Burger, HG. Diagnostic role of follicle stimulating hormone (FSH) ... Aging and Disease. 2013, 4 (6): 320-28. ISSN 2152-5250. doi:10.14336/AD.2013.0400320.. ... EFSA Femarelle® and bone mineral density (页面存档备份,存于互联网档案馆) Scientific substantiation of a health claim related to "Femarelle®" ...
"Stem-cell-based strategies for the treatment of Parkinson's disease". 》Neuro-Degenerative Diseases》 4 (4): 339-347. ISSN 1660- ... "Application of stem cells in bone repair". 》Skeletal Radiology》 37 (7): 601-608. ISSN 0364-2348. PMID 18193216. doi:10.1007/ ... "Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells". 》Nature Biotechnology》 24 (11): ... "Designer's microglia with novel delivery system in neurodegenerative diseases". 》Medical Hypotheses》 83 (4): 510-512. ISSN ...
"MANAGEMENT OF ENDOCRINE DISEASE: Reversible hypogonadotropic hypogonadism". European Journal of Endocrinology. 174 (6): R267-74 ... Bone density scans are recommended to monitor the bone mineral density.[13] ... Laitinen EM, Hero M, Vaaralahti K, Tommiska J, Raivio T (August 2012). "Bone mineral density, body composition and bone ... "Treatment of isolated hypogonadotropic hypogonadism effect on bone mineral density and bone turnover". The Journal of Clinical ...
endocrine gland. A gland of the animalian endocrine system that secretes hormones directly into the blood rather than through a ... The fibrous connective tissue that connects bones to other bones and is also known as articular ligament, articular larua, ... The science of diagnosing and managing plant diseases.. placebo. A substance or treatment of no intended therapeutic value.. ... endocrine system. The collection of glands that produce hormones which regulate metabolism, growth and development, tissue ...
"Overview of samarium sm 153 lexidronam in the treatment of painful metastatic bone disease". Rev Urol. 6 Suppl 10 (Suppl 10): ... Radiation therapy is used to treat early stage Dupuytren's disease and Ledderhose disease. When Dupuytren's disease is at the ... valvular heart disease, coronary artery disease, heart arrhythmia and peripheral artery disease. Radiation-induced fibrosis, ... Cardiovascular disease. Radiation can increase the risk of heart disease and death as observed in previous breast cancer RT ...
Joint WHO/FAO expert consultation (2003). Diet, Nutrition and the Prevention of Chronic Diseases (PDF). who.int. Geneva: World ... bone health and cancer risk.[23] One low quality meta-analysis reported that adverse effects could include "constipation, ... The Endocrine Society stated that "when calorie intake is held constant [...] body-fat accumulation does not appear to be ... "Nutrition, Metabolism, and Cardiovascular Diseases. 24 (4): 337-43. doi:10.1016/j.numecd.2013.12.008. PMC 4351995. PMID ...
"Islet Cell Tumors of the Pancreas / Endocrine Neoplasms of the Pancreas". The Sol Goldman Pancreas Cancer Research Center. ... Zhan HX, Xu JW, Wu D, Zhang TP, Hu SY (2015). "Pancreatic cancer stem cells: New insight into a stubborn disease". Cancer Lett ... See page 95 for citation regarding "... lesser degree of involvement of bones and brain and other anatomical sites." ... Harris, RE (2013). "Epidemiology of pancreatic cancer". Epidemiology of Chronic Disease. Jones & Bartlett. s. 181-190. ISBN 978 ...
Mouth diseases include tongue diseases and salivary gland diseases. A common gum disease in the mouth is gingivitis which is ... It is both an endocrine gland and an exocrine gland.[29] The endocrine part secretes insulin when the blood sugar becomes high ... They are made of a bone-like material called dentin, which is covered by the hardest tissue in the body-enamel.[8] Teeth have ... It can also arise as a result of other gastrointestinal diseases such as coeliac disease. Coeliac disease is an autoimmune ...
... her bone age was 11 or 12 years, and at the age of 17 years, 8 months, her bone age was 13.5 years.[9] Her bone mass was lower ... "What have we learned about GPER function in physiology and disease from knockout mice?". J. Steroid Biochem. Mol. Biol. 153: ... Human female endocrine system. *Intersex variations. Hidden categories: *Wikipedia articles with style issues from July 2017 ... Bone age is delayed and bones are more brittle.[citation needed] Variations in these patterns can be achieved by selectively ...
For endocrine problemsEdit. androgens, antiandrogens, estrogens, gonadotropin, corticosteroids, human growth hormone, insulin, ... HRT is not a life-saving drug, nor does it cure any disease. HRT has been prescribed to improve one's quality of life. Doctors ... NSAIDs, anticholinergics, haemostatic drugs, antifibrinolytics, Hormone Replacement Therapy (HRT), bone regulators, beta- ... It describes plant-based drugs to counter diseases.[31] The earliest foundations of ayurveda were built on a synthesis of ...
Immune disease. (L03-L04). *Immunomodulators *Immunostimulants. *Immunosuppressants. Muscles, bones,. and joints (M). *Anabolic ... Endocrine. system (H). *Hypothalamic-pituitary hormones. *Corticosteroids *Glucocorticoids. *Mineralocorticoids. *Sex hormones ...
Cardiovascular disease[edit]. Evidence suggests that dietary vitamin D may be carried by lipoprotein particles into cells of ... Cosman F, Nieves J, Dempster D, Lindsay R (December 2007). "Vitamin D economy in blacks". Journal of Bone and Mineral Research ... "Evidence for alteration of the vitamin D-endocrine system in blacks". The Journal of Clinical Investigation. 76 (2): 470-3. ... Vieth R (December 2007). "Vitamin D toxicity, policy, and science". Journal of Bone and Mineral Research. 22 Suppl 2: V64-8. ...
Deficiency impairs bone mineralization, leading to bone softening diseases such as rickets in children. It can also worsen ... Alpert PT, Shaikh U (October 2007). "The effects of vitamin D deficiency and insufficiency on the endocrine and paracrine ... causing overt bone disease from before birth and impairment of bone quality after birth.[9][14] ... "Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease". The ...
2015). Epidemiology and Prevention of Vaccine-Preventable Diseases. U.S. Dept. of Health & Human Services, Centers for Disease ... "Joint, Bone, Spine : Revue du Rhumatisme. 81 (2): 118-24. doi:10.1016/j.jbspin.2014.01.001. PMID 24556284.. ... Conjunctivitis is the most common eye disease.[34] Rates of disease is related to the underlying cause which varies by the age ... "Centers for Disease Control and Prevention. Retrieved 2018-12-07.. *^ "Allergic Conjunctivitis". familydoctor.org. Archived ...
Endocrine surgery Traumatic reconstruction Balance Skull base surgery Anterior skull base Swallowing disorders Airway Sleep ... Patients seek treatment from an otorhinolaryngologist for diseases of the ear, nose, throat, base of the skull, and for the ... Temporal bone Allergy Phono-surgery Cleft lip and palate Sleep apnea surgery ...
"Multiple melanocortin receptors are expressed in bone cells". Bone. 36 (5): 820-31. doi:10.1016/j.bone.2005.01.020. PMID ... Addison's disease) when adrenal gland production of cortisol is chronically deficient. In Cushing's disease a pituitary tumor ... Isales CM, Zaidi M, Blair HC (March 2010). "ACTH is a novel regulator of bone mass". Annals of the New York Academy of Sciences ... Addison's disease, the primary adrenal insufficiency (another form of hypocorticism). *Cushing's syndrome, hypercorticism, one ...
Examples include Gaucher disease, Fabry disease, Mucopolysaccharidoses and Glycogen storage disease type II. Such treatments ... endocrine, cardiovascular, pulmonary, ophthalmologic, renal, psychiatric, and dermatologic conditions. ... Bone marrow transplantation. *Gene therapy. Career paths and training[edit]. The examples and perspective in this article deal ... Allelic architecture of disease[edit]. Main article: Population groups in biomedicine. Sometimes the link between a disease and ...
Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. 13. Springer. pp. 81-137. doi: ... The effector organs of the first homeostatic mechanism are the bones, the kidney, and, via a hormone released into the blood by ... Two other regulatory endocrine axes are the hypothalamic-pituitary-adrenal axis (HPA axis) and the hypothalamic-pituitary- ... Many diseases are the result of a homeostatic failure. Almost any homeostatic component can malfunction either as a result of ...
ಕೆಲವು ಮೆನಿಂಗಿಯೊಮಾಸ್ ಪ್ರಕರಣಗಳಲ್ಲಿರುವ ಬುರುಡೆಯಲ್ಲಿ ಅಪರೂಪವಾಗಿರುವ ಗೆಡ್ದೆಗಳನ್ನು ಶಸ್ತ್ರಚಿಕಿತ್ಸೆ ಮೂಲಕ ಯಶಸ್ವಿಯಾಗಿ ತೆಗೆಯಬಹುದು. [೮]ಬಹಳಷ್ಟು ಕಠಿಣ ಪ್ರಕರಣಗಳಲ್ಲಿ ಸ್ಟಿರಿಯಿಟ್ಯಾಕ್ಟಿಕ್ ರೇಡಿಯೊ ಶಸ್ತ್ರಚಿಕಿತ್ಸೆ,ಅಂದರೆ ಗಾಮಾ ಚೂರಿ ಬಳಕೆ,ಸೈಬರ್ ನೈಫ್ ಅಥವಾ ನೊವಿಲಿಸ್ Tx ರೇಡಿಯೊ ಶಸ್ತ್ರಚಿಕಿತ್ಸೆಯು ಅತ್ಯಂತ ಉಪಯುಕ್ತ [೯]ಆಯ್ಕೆಯಾಗಿದೆ. ಬಹಳಷ್ಟು ಪಿಟ್ಯುಟರಿ ಅಡೆನೊಮಾಗಳನ್ನು ಶಸ್ತ್ರಚಿಕಿತ್ಸೆ ಮೂಲಕ ತೆಗೆಯಲಾಗುತ್ತದೆ.ಅಂದರೆ ...
... reduction in bone breakdown and neuroprotection. GLP-2 may act in an endocrine fashion to link intestinal growth and metabolism ... GLP-2 and related analogs may be treatments for short bowel syndrome, Crohn's disease, osteoporosis and as adjuvant therapy ... GLP-2 is produced by the intestinal endocrine L cell and by various neurons in the central nervous system. Intestinal GLP-2 is ...
Endocrine Calcium Center helps streamline the evaluation and treatment of problems associated with calcium disorders and ... Metabolic Bone Disease & Endocrine Calcium Center Metabolic Bone Disease & Endocrine Calcium Center ... Elevated markers of bone turnover. The Metabolic Bone Disease & Endocrine Calcium Center may also provide evaluation and ... The Metabolic Bone Disease & Endocrine Calcium Center and the Department of Endocrine Surgery continue to collaborate to ...
An endocrine bone disease is a bone disease associated with a disorder of the endocrine system. An example is osteitis fibrosa ... which in turn leads to condition that are not desirable such as bone disorders or other endocrine related diseases. Bone ... therefore are associated with the endocrine bone disease. Some common endocrine disorders are hypothyroidism, hyperthyroidism, ... Joplin, GF (1973). "Endocrine bone disease". Proceedings of the Royal Society of Medicine. 66 (5): 447. doi:10.1177/ ...
Endocrine disruption of vitamin D activity by perfluoro-octanoic acid (PFOA) *Andrea Di Nisio ... Metabolic bone disease. Definition. Metabolic bone disease describes a diverse group of disorders of bone metabolism, most ... Mass spectrometric quantitation of AGEs and enzymatic crosslinks in human cancellous bone *Shoutaro Arakawa ... Anabolic agents represent a novel approach to improving bone quality in people with osteoporosis. This Review discusses ...
... , Critical Illness Related Metabolic Bone Disease, Osteoporosis Secondary to ICU ... Metabolic Bone Disease Following ICU Admission. Metabolic Bone Disease Following ICU Admission Aka: Metabolic Bone Disease ... Search other sites for Metabolic Bone Disease Following ICU Admission NLM Pubmed Google Websites Google Images QuackWatch ... These images are a random sampling from a Bing search on the term "Metabolic Bone Disease Following ICU Admission." Click on ...
Endocrine and Diseases of the Metabolism, Bones and Kidneys. *Diseases of the Liver and Digestive Tract ...
The annual Endocrine Fellows Series: Osteoporosis and Metabolic Bone Diseases is a CME-certified conference of pediatric and ... Identify patients with Pagets disease. *Evaluate best treatment strategies for the management of patients with Pagets disease ... Pagets disease, adult forms of osteogenesis imperfecta, fibrous dysplasia of bone, etc.) ... adult endocrine fellows held in conjunction with the Santa Fe Bone Symposium (August 3-4,2018) in Santa Fe, New Mexico. Faculty ...
Paget disease of bone is a disorder that causes bones to grow larger and weaker than normal. Explore symptoms, inheritance, ... Singer FR, Bone HG 3rd, Hosking DJ, Lyles KW, Murad MH, Reid IR, Siris ES; Endocrine Society. Pagets disease of bone: an ... Other complications of Paget disease of bone depend on which bones are affected. If the disease occurs in bones of the skull, ... Paget disease of bone is a disorder that causes bones to grow larger and weaker than normal. Affected bones may be misshapen ...
... and other resources related to the treatment of bone disease and parathyroid disorders such as osteoporosis, osteopenia and ... AACEs Bone and Parathyroid Center provides its members access to clinical practice guidelines, treatment algorithms, ... to keep them on the leading edge of treatment of patients with endocrine diseases. Endocrine Practice is peer-reviewed, ... DISEASE STATE RESOURCES *Adrenal *Bone and Parathyroid *Diabetes *Lipids and CV Health *Nutrition and Obesity *Pituitary and ...
Bone Diseases. Musculoskeletal Diseases. Hematologic Diseases. Paraganglioma. Head and Neck Neoplasms. Endocrine System ... Bone Neoplasms. Pheochromocytoma. Thyroid Neoplasms. Endocrine Gland Neoplasms. Adrenal Gland Neoplasms. Bone Marrow Diseases. ... Cryoablation of Bone Metastases From Endocrine Tumors. The safety and scientific validity of this study is the responsibility ... change in the local disease status of the cryoablation treated bone metastases [ Time Frame: baseline (preprocedure); 01 week, ...
Metabolic Diseases. Bone Diseases, Metabolic. Bone Diseases. Musculoskeletal Diseases. Spinal Cord Diseases. Central Nervous ... for twelve months can decrease their endocrine metabolic disease risk by increasing bone density and reducing inflammation. ... Statin Monotherapy for Treatment of Endocrine Metabolic Disease Risk (RoBaCO). The safety and scientific validity of this study ... Data Collected: Subjects bone density will be collected at the start and end of the study. Change in bone density between the ...
Endocrine disorders Diabetes mellitus * 1/22 (4.55%) 1. Hyperglycemia * 2/22 (9.09%) 2. ... Bone Marrow Transplantation in Young Adults With Severe Sickle Cell Disease (STRIDE). The safety and scientific validity of ... Individuals receiving a bone marrow... Arm/Group Description Individuals receiving a bone marrow transplant at one of 10 study ... Bone Marrow Transplant Recipients Comments This statistical analysis is the paired difference in t-scores of the anxiety domain ...
Bone Diseases. Musculoskeletal Diseases. Metabolic Diseases. Gonadal Disorders. Endocrine System Diseases. Alendronate. ... Condition or disease Intervention/treatment Phase Hypogonadism Osteopenia Osteoporosis Drug: Testosterone Drug: Alendronate ... This study will investigate the hypothesis that the combination of testosterone replacement and alendronate will improve bone ... density and parameters of bone quality more than either medication alone in older men with low testosterone levels and low bone ...
Digestive system diseases. *Emergency medicine. *Endocrine system diseases. *Environment and public health ... Bone 2002; 31: 616-619.. *8. Siris ES, Ottman R, Flaster E, Kelsey JL. Familial aggregation of Pagets disease of bone. J Bone ... Bone 2002; 31: 366-373.. *4. Cooper C, Dennison E, Schafheutle K, et al. Epidemiology of Pagets disease of bone. Bone 1999; 24 ... Pagets disease of bone is common, affecting up to 4% of Australians over the age of 55 years. The incidence of the disease and ...
Growth and endocrine function in children with acute myeloid leukaemia after bone marrow transplantation using busulfan/ ... 77] ) must be weighed against the risks of bone and heart disease. The role of bisphosphonates to help prevent low bone mineral ... 72] bone fractures, [73] lipid disorders, and ischemic heart disease. [74, 75, 76] Use of steroids and radiotherapy can ... Weight loss and reduced body mass index: a critical issue in children with multiorgan chronic graft-versus-host disease. Bone ...
Endocrine system diseases. *Environment and public health. *Environment and public healthIndigenous health ... which is pathognomonic of advanced Paget disease affecting the skull.1,2 Her leg weakness leading to the falls was due to the ...
Journal Name: Endocrine Reviews. Publish Date: April 2007. Volume/Page: 28(2):151-64. ... aka cancellous bone). Trabecular bone is the primary bone of the spine, whereas cortical bone is the primary bone of the legs ... Minimal trauma fractures in bone diseases are the result of bone fragility. Rather than considering bone fragility as being the ... Primer on the metabolic bone diseases and disorders of mineral metabolism. Washington, DC: American Society for Bone and ...
Metastatic Bone Disease. Multiple Endocrine Neoplasia Type 2 (MEN 2). Nasopharyngeal Cancer. ...
Metastatic Bone Disease. Multiple Endocrine Neoplasia Type 2 (MEN 2). Multiple Myeloma. ...
... the administration of a bone resorption inhibitor during a period of approximately 12 to 36 months. ... The invention relates to a combined pharmaceutical preparation comprising parathyroid hormone and a bone resorption inhibitor, ... Endocrine Reviews 1993, vol. 14, 690-709). PTH has a multitude of effects on bone. Part of it is through the remodeling cycle. ... A method for treating bone-related diseases which comprises administering to a patient an effective amount of a bone resorption ...
Co-Director, Bone Disease Program of Texas. Professor, Endocrine Neoplasia & Hormonal Disorders. MD Anderson Cancer Center ... to establish the Bone Disease Program of Texas. Over the past three decades, Gagel has made significant contributions to bone ... Director, Bone Disease Program of Texas. Leah L. Lewis Distinguished Chair. Professor and Division Head, Pediatric Research ... Co-Director, Bone Disease Program of Texas. Professor, Howard Hughes Medical Institute. Department of Molecular and Human ...
130 Endocrine Bioenergetics of Bone 1012. Patricia F. Ducy and Gerard Karsenty. 131 Central Neuronal Control of Bone Remodeling ... and researchers working in the field of bone health and disease, Primer on the Metabolic Bone Diseases and Disorders of Mineral ... Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism The authoritative reference to bone diseases and ... 57 Bone Stress Injuries 450. Stuart J. Warden and David B. Burr. 58 Inflammation-Induced Bone Loss in the Rheumatic Diseases ...
"Pagets disease of bone: an endocrine society clinical practice guideline". The Journal of Clinical Endocrinology and ... and does not spread from bone to bone. Rarely, a bone affected by Pagets disease can transform into a malignant bone cancer. ... Ethel, SS; Roodman, GD (2008). "Pagets disease of bone". In Rosen. Primer on the metabolic bone diseases and disorders of ... Pagets Disease of Bone Overview - NIH Osteoporosis and Related Bone Diseases ~ National Resource Center. ...
My research focuses on the dual fields of bone disease and obesity metabolism. Within the bone field, my ongoing research ... Elaine W. Yu, MD, MMSc is a clinical researcher and endocrinologist in the Endocrine Unit at the Massachusetts General Hospital ... for the in vivo assessment of bone microarchitecture, microindentation for the estimation of cortical bone material strength ... Key bone techniques that I am utilizing include high-resolution peripheral quantitative computed tomography (HR-pQCT) ...
Bone Diseases, Metabolic / etiology * Bone Diseases, Metabolic / pathology * Endocrine System Diseases / complications* ... Iron Overload Associated Endocrine Dysfunction Leading to Lower Bone Mineral Density in Thalassemia Major J Clin Endocrinol ... Context: Patients with thalassemia major (TM) have a lower bone mineral density (BMD) and higher risk of fracture than the ... Outcome measurements: Endocrine profiles, including thyroid, parathyroid, and pituitary function, glucose, vitamin D, calcium, ...
... skeletal disorder characterized by localized excessive osteoclastic bone resorption that is followed by compensatory increased ... Pagets disease of bone (PDB) is a noninflammatory, metabolic, ... Pagets disease of bone: an endocrine society clinical practice ... Pagets disease of bone is the paradigm of a focal bone disorder with accelerated bone turnover [4]. It is a noninflammatory, ... Pagets disease of bone. In: Rosen CJ, Compston JE, Lian JB, editors. Primer on the metabolic bone diseases and disorders of ...
endocrine, nutritional and metabolic diseases (E00-E88). *injury, poisoning and certain other consequences of external causes ( ... Disease, diseased - see also Syndrome* bone - see also Disorder, bone* aluminum M83.4 ... Aluminum bone disease. 2016 2017 2018 Billable/Specific Code *M83.4 is a billable/specific ICD-10-CM code that can be used to ... Diseases of the musculoskeletal system and connective tissue. Note*Use an external cause code following the code for the ...
... and tips on preventing the disease and preventing fractures. ... Diseases that can affect bones *endocrine (hormone) diseases ( ... The body removes old bone (called bone resorption) and replaces it with new bone (bone formation). By their mid-30s, most ... Osteoporosis results from a loss of bone mass (measured as bone density) and from a change in bone structure. Many factors will ... Osteoporosis results from a loss of bone mass (measured as bone density) and from a change in bone structure. Many factors will ...
This study will determine the prevalence of endocrine-related side effects in children who have been treated for cancer and ... Bone Diseases, Metabolic. *Growth Factor. *Hypothalamic-Pituitary Dysfunction. *Primary Disorders of the Thyroid ... the context of the pediatric and adult endocrine outpatient clinics: every eligible patient. referred to the endocrine service ... Endocrine dysfunction is increasingly recognized as one of the most important aspects of. quality of life issues, physical and ...
Advances in Treating Metastatic Bone Cancer Src Inhibitors in Metastatic Bone Disease. Brendan F. Boyce, Lianping Xing, ... Bone-targeted 2,6,9-trisubstituted purines: novel inhibitors of Src tyrosine kinase for the treatment of bone diseases. Bioorg ... Endocrine 1995;136:5751-9.. *↵ Miyazaki T, Sanjay A, Neff L, et al. Src kinase activity is essential for osteoclast function. J ... Generally, if bone resorption is stopped while the tumor cells are in the bone, the bone erosion is inhibited, but tumor cells ...
... the chance of developing graft-versus-host disease following ... Bone marrow that has been treated to remove certain white blood ... Endocrine therapy:. - At least 3 weeks since prior hormonal therapy and recovered. Radiotherapy:. - See Disease Characteristics ... unrelated bone marrow transplantation in reducing grade III/IV acute graft vs host. disease (GVHD) in patients with acute or ... Unrelated bone marrow donor available. - If matched at 6 of 6 HLA-A, -B, and -DR loci, patient must be 12 to 50 years. - If ...
  • such as function of thyroid, parathyroid, liver and kidney disrupts metabolic changes as well as function of specific organs, which in turn leads to condition that are not desirable such as bone disorders or other endocrine related diseases. (wikipedia.org)
  • There are many bone disorders such as osteoporosis, Paget's disease, hypothyroidism. (wikipedia.org)
  • Endocrine disorder is more common in women than men, as it is associated with menstrual disorders. (wikipedia.org)
  • The Metabolic Bone Disease & Endocrine Calcium Center is comprised of a team of expert physician-scientists who specialize in the treatment of a vast number of common and rare bone, calcium and other mineral disorders associated with the regulation of skeletal and parathyroid hormone functions. (clevelandclinic.org)
  • Metabolic bone disease describes a diverse group of disorders of bone metabolism, most commonly caused by abnormalities of minerals (such as calcium or phosphorous) or vitamin D. (nature.com)
  • Faculty members present clinical content that incorporate practice guidelines, newly reported research findings, preclinical research and clinical practice patterns from across the field of bone and calcium disorders. (endocrine.org)
  • Gagel has focused on the clinical management of osteoporosis and other disorders of bone metabolism. (mdanderson.org)
  • The authoritative reference to bone diseases and disorders of mineral metabolism, revised and update. (wiley-vch.de)
  • Now in its ninth edition, The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone and mineral health. (wiley-vch.de)
  • The ninth edition provides concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. (wiley-vch.de)
  • The new edition of this invaluable reference expands coverage and includes the most recent developments in the field that help to strengthen its usefulness and ensure that the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism maintains its place as the pre-eminent reference on bone and mineral health. (wiley-vch.de)
  • Written for advanced students, clinicians, and researchers working in the field of bone health and disease, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease. (wiley-vch.de)
  • Although Paget's disease and osteoporosis can occur in the same patient, they are different disorders. (wikipedia.org)
  • Metabolic disorders include numerous diseases, often inherited, in which chemical processes necessary for metabolism are not functioning properly. (castleconnolly.com)
  • 10 percent of adults), thyroid disorders (~8 percent of adults), and less common problems such as hypothalamic/pituitary disorders, adrenal disorders, and pancreatic endocrine disorders. (castleconnolly.com)
  • We develop care plans using the latest technological advancements in diagnosis and treatment of endocrine disorders. (cookchildrens.org)
  • The branch of medicine that studies the endocrine disorders is known as endocrinology. (tutorialspoint.com)
  • This late age of onset is largely due to the increased preponderance of the conditions causing the symptom in older individuals - such as muscular weakness and neurological disorders like Parkinson's disease . (wikipedia.org)
  • BSS often appears in individuals afflicted with Parkinson's disease , muscular dystrophies , endocrine disorders , inflammatory conditions ( myositis ), or mitochondrial myopathies . (wikipedia.org)
  • Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. (bookdepository.com)
  • and features detailed coverage of disorders by system, as well as, metabolic bone diseases, neuroendocrine tumors, and more. (wiley.com)
  • Coverage includes the presentation, diagnosis, management, and treatment of endocrine and metabolic disorders in an acute care setting, as well as the most up-to-date guidance on issues including clinical lipidology, glucose, sodium, calcium and phosphate, and more. (wiley.com)
  • Symptoms of some endocrine disorders are similar to many other conditions. (mainehealth.org)
  • How are pediatric endocrine disorders treated? (mainehealth.org)
  • An endocrinologist is a medical professional who treats disorders of the endocrine system. (stormontvail.org)
  • At Stormont Vail Health, we treat patients of all ages with many types of endocrine disorders. (stormontvail.org)
  • From 1998 she has been Director of the Clinical Unit on Metabolic Bone Disorders, University Hospital of Florence. (iofbonehealth.org)
  • and inherited bone disorders. (iofbonehealth.org)
  • The Fibrous Dysplasia Foundation is launching the study in collaboration with the National Organization for Rare Disorders (NORD), an independent charity that built its natural history study platform as part of its mission to help identify and treat all 7,000 rare diseases. (rarediseases.org)
  • Georgetown Lombardi faculty conducts research and provides care on many diseases and disorders, with a particular focus and expertise on cancer. (georgetown.edu)
  • Expertise and experience is available in a variety of endocrine and metabolic disorders. (montefiore.org)
  • Her clinical interests include type 1 and type 2 diabetes mellitus, bone diseases, adrenal disorders, female reproductive disorders, polycystic ovary syndrome, and pituitary disease. (mssm.edu)
  • The condition can also arise as a result of other endocrine disorders, such as hyperthyroidism (overactive thyroid). (livescience.com)
  • In the 1800s, scientists began to think that some sort of chemical communication must take place between different organs in the body, and they later recognized that certain disorders could be treated with extracts from endocrine tissues. (livescience.com)
  • This book comprehensively describes bone metabolism and diverse bone metabolic disorders from an endocrine medicine perspective. (foyles.co.uk)
  • Moreover, it addresses not only common bone diseases, but also more recent discoveries concerning rare skeletal disorders. (foyles.co.uk)
  • Aliya Khan is a Professor of Clinical Medicine, Divisions of Endocrinology and Metabolism and Geriatrics at McMaster University , Director of the Calcium Disorders Clinic and Director of the Fellowship program in Metabolic Bone Disease at McMaster University. (foyles.co.uk)
  • Those with bone growth disorders can sometimes be treated with surgery, or physical therapy. (wikipedia.org)
  • Based in the Department of Endocrinology, the Metabolic Bone Disease & Endocrine Calcium Center provides superior access to a multidisciplinary team, providing Center-of-Excellence DXA bone density testing and interpretation, on-site laboratory testing, and a fully staffed infusion center for even the most sophisticated testing and drug administration requirements. (clevelandclinic.org)
  • In addition we will ask colleagues in other Endocrinology Departments (or other specialties such as Clinical Genetics,Pathology, General Medicine ) to identify potentially suitable patients with endocrine & pituitary tumours from their records. (clinicaltrials.gov)
  • Endocrinology is a subspecialty of internal medicine that focuses on the diagnosis and care of diseases related to endocrine glands, hormones and metabolism. (castleconnolly.com)
  • By mastering the principles involved in evaluating a child with a potential endocrine condition and developing a sound knowledge base of endocrinology, the pediatric resident will be prepared to perform well as a general pediatrician in the community after graduation. (slideshare.net)
  • Camacho P. Metabolic Bone Diseases in Evidence Based Endocrinology 2nd edition. (endocrineweb.com)
  • Cellular Endocrinology in Health and Disease describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. (bookdepository.com)
  • Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. (bookdepository.com)
  • Endocrinology covers some of the most common conditions and serious public health challenges facing medicine today, and endocrine and metabolic emergencies constitute a large proportion of the clinical workload. (wiley.com)
  • When you come to the Cotton O'Neil Diabetes & Endocrinology Center, our endocrine specialists will make sure that you receive the correct diagnosis and a personalized treatment plan. (stormontvail.org)
  • The Division of Endocrinology maintains a robust basic and clinical research program in thyroid diseases and particularly in the area of obesity and diabetes. (montefiore.org)
  • Dr. Skamagas is currently an Assistant Professor in the Division of Endocrinology, Diabetes, and Bone Disease. (mssm.edu)
  • Issam Cheikh, MD, FACP, FACE, is chief of the Division of Endocrinology, Diabetes, and Metabolism and director of the Diabetes and Endocrine Center at MedStar Union Memorial Hospital. (medstarhealth.org)
  • He founded the Division of Endocrinology at MedStar Union Memorial Hospital and developed the endocrinology fellowship training program along with one of the largest diabetes and endocrine practices in the region. (medstarhealth.org)
  • Endocrinology is the branch of biology and medicine that focuses on the endocrine system, and although the terms "endocrine" and "endocrinology" didn't come into common usage until the 1800s, the study of endocrinology can be traced back to China over 2,000 years ago, according to American author Robert K. G. Temple in his book, "The Genius of China: 3,000 Years of Science, Discovery, and Invention" (Prion, 1998). (livescience.com)
  • Her clinical research interests are in the areas of bone metabolism and obesity. (massgeneral.org)
  • My research focuses on the dual fields of bone disease and obesity metabolism. (massgeneral.org)
  • In addition, recent data suggest the influence of bone metabolism on energy balance which may be relevant for cardiovascular disease. (elsevier.es)
  • These developments were paralleled by significant progress in our understanding of the local regulation of bone metabolism. (endocrine-abstracts.org)
  • The endocrine system works inside you to regulate your metabolism, proper growth and development of muscles and tissues, as well as tissue function, sexual function, reproduction, sleep and mood, among other things. (juicing-for-health.com)
  • Vitamin D deficiency results in abnormalities in calcium, phosphorous, and bone metabolism. (aace.com)
  • The term 'metabolic bone disease' encompasses an unrelated group of systemic conditions that impact on skeletal collagen and mineral metabolism. (scielo.org.za)
  • Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. (thefreedictionary.com)
  • Impaired glucose metabolism is common and contributes to the risk of diabetes and cardiovascular disease. (medscape.com)
  • New therapeutic approaches to diabetes and heart disease may be anticipated if this bone-derived protein is involved in the regulation of glucose metabolism and cardiovascular risk. (medscape.com)
  • We investigated the metabolic phenotype associated with impaired bone metabolism in mice lacking the gene that encodes NPP1 ( Enpp1 −/− mice). (biologists.org)
  • She has been or is on the editorial boards of major scientific journals and is currently Editor-in-Chief of Clinical Cases in Bone and Mineral Metabolism. (iofbonehealth.org)
  • Recognizing endocrinologists' growing interest in the field of bone metabolism, it provides expert guidance and represents an innovative and unique compendium. (foyles.co.uk)
  • citation needed] The thyroid, parathyroid, pituitary, or adrenal glands, and the pancreas are parts of the endocrine system, and, therefore are associated with the endocrine bone disease. (wikipedia.org)
  • The Metabolic Bone Disease & Endocrine Calcium Center team has partnered with their highly skilled Endocrine Surgery colleagues to provide timely, integrated assessment of parathyroid abnormalities with ultrasonography, direct laryngoscopy, and other state of the art testing. (clevelandclinic.org)
  • The Metabolic Bone Disease & Endocrine Calcium Center and the Department of Endocrine Surgery continue to collaborate to provide comprehensive pre-surgical assessment, timely surgical intervention, and post-surgical follow up for all patients with parathyroid disease in their care. (clevelandclinic.org)
  • b) after the administration of parathyroid hormone has been terminated, the administration of a bone resorption inhibitor during a period of approximately 12 to 36 months. (google.com)
  • Parathyroid hormone and vitamin D interactions work to release calcium from the bones, gut, and kidneys for deposit into the bloodstream. (petmd.com)
  • Delivering the highest quality care with a wealth of expertise behind them, our team of more than 40 board-certified physicians focus on the treatment and management of nearly every endocrine disorder, ranging from growth complexities to diseases of the parathyroid and pancreas. (montefiore.org)
  • Also, two somatic heterozygous NONO mutations were found in endocrine-related tumors, p.H146R (parathyroid) and p.R293H (small intestine neuroendocrine tumor). (bireme.br)
  • The eight hormone-secreting glands of the endocrine system are the adrenal gland, hypothalamus, pancreas, parathyroid gland, pineal gland, pituitary gland, reproductive glands (ovaries and testes) and thyroid gland. (livescience.com)
  • She is the Editor of the Handbook of Parathyroid Diseases. (foyles.co.uk)
  • Osteoclasts are cells of bones that promote bone demineralization or bone resorption. (wikipedia.org)
  • Thus Calcitonin activates osteoblasts, therefore decrease blood calcium levels by decreasing bone breakdown (resorption) by inhibiting osteoclast. (wikipedia.org)
  • P aget's disease of bone is a chronic disorder, characterised by focal areas of excessive osteoclastic bone resorption accompanied by a secondary increase in osteoblastic bone formation. (mja.com.au)
  • 4. A pharmaceutical preparation according to claim 1 adapted for said administration of bone resorption inhibitor for approximately 12 to 36 months. (google.com)
  • 5. A pharmaceutical preparation according to claim 4 , adapted for said administration of bone resorption inhibitor for approximately 12 to 18 months. (google.com)
  • 7. A preparation according to claim 1 wherein the said bone resorption inhibitor is a bisphosphonate. (google.com)
  • 9. A preparation according to claim 1 wherein the said bone resorption inhibitor is a substance with estrogen-like effect. (google.com)
  • Over the past three decades, Gagel has made significant contributions to bone research, including studies on calcitonon, a major regulator of bone resorption. (mdanderson.org)
  • Paget's disease of bone (PDB) is a noninflammatory, metabolic, skeletal disorder characterized by localized excessive osteoclastic bone resorption that is followed by compensatory increased osteoblastic activity leading to unstructured, fibroblastic, and biomechanically unstable bone. (springer.com)
  • The body removes old bone (called bone resorption) and replaces it with new bone (bone formation). (rheumatology.org)
  • This led to the discovery or development of specific inhibitors of some of these key enzymes, including Src, as proof-of-concept lead compounds or potential clinical candidates for the prevention of diseases associated with increased bone resorption, such as osteoporosis and metastatic bone disease. (aacrjournals.org)
  • In this article, we review our current understanding of the signaling pathways that regulate osteoclast formation, activation, and survival with specific reference to the role of Src tyrosine kinase and downstream signaling and highlight in a variety of models of increased bone resorption the effects of Src kinase inhibitors that have been targeted to bone to limit potential adverse effects on other cells. (aacrjournals.org)
  • Chronic localized bone remodeling disorder characterized by increased bone resorption, bone formation, and remodeling, which may lead to major long bone and skull deformities. (bmj.com)
  • Despite reduction of bone resorption, OPG did not inhibit AIA-induced bone loss. (springer.com)
  • a product of the resorption of bone. (thefreedictionary.com)
  • This study will evaluate the clinical response and safety of cone beam computed-tomography guided percutaneous cryoablation in bone metastases from thyroid, adrenal and neuroendocrine tumors in 30 patients. (clinicaltrials.gov)
  • Thyroid neoplasms, as well as adrenal and neuroendocrine tumors have the potential to metastasize to bone. (clinicaltrials.gov)
  • About 3% of patients with well-differentiated thyroid carcinomas develop secondary bone lesions, while adrenal and neuroendocrine tumors have 10% and 13% bone metastases rates, respectively. (clinicaltrials.gov)
  • Pituitary tumors are often harmless, but some can cause diseases, such as hyperthyroidism. (stormontvail.org)
  • When tumors are present in the adrenal gland, they negatively affect the way the body produces these hormones and often result in diseases that lead to hypertension, weakening of the muscles, weight gain, buffalo humps and bruising. (providence.org)
  • Adrenal surgery is used to treat those diseases by removing benign and malignant tumors within the adrenal gland. (providence.org)
  • Since 1990 she has been Director, Regional Center on Hereditary Endocrine Tumors, University Hospital of Florence. (iofbonehealth.org)
  • Graves-Basedow disease is a medical disorder that may manifest several different conditions including hyperthyroidism (over activity of thyroid hormone production), infiltrative exophthalmos (protruberance of one or both eyes and associated problems) and infiltrative dermopathy (a skin condition usually of the lower extremities). (dailystrength.org)
  • When the endocrine system isn't working properly, you may be diagnosed with an endocrine disorder, such as diabetes or hyperthyroidism. (stormontvail.org)
  • The most common cause of hyperthyroidism in the US is overproduction of thyroid hormone due to Graves' disease , toxic multinodular goiter or a toxic adenoma. (providence.org)
  • While some of the symptoms of hyperthyroidism and hypothyroidism are similar to those in younger patients, it is not uncommon for both hyperthyroidism and hypothyroidism to be manifest in subtle ways in older patients, often masquerading as diseases of the bowel or heart or a disorder of the nervous system. (thyroid.org)
  • While Graves' disease is still a common cause of hyperthyroidism, toxic nodular goiter is seen more frequently in the older patient. (thyroid.org)
  • An endocrine bone disease is a bone disease associated with a disorder of the endocrine system. (wikipedia.org)
  • Deficiency in Vitamin D or renal disease contributes to bone disorder such as in Osteomalacia in adult and Rickets in children. (wikipedia.org)
  • Bone disease is common among the elderly individual, but adolescents can be diagnosed with this disorder as well. (wikipedia.org)
  • Paget disease of bone is a disorder that causes bones to grow larger and weaker than normal. (medlineplus.gov)
  • Although there is no cure for Paget's disease, medications (bisphosphonates and calcitonin) can help control the disorder and lessen pain and other symptoms. (wikipedia.org)
  • Low energy (with or without an eating disorder) in combination with menstrual disorder and altered mineral bone density is known as the female athlete triad . (medscape.com)
  • A chronic bone disorder that is characterized by focal areas of increased bone remodeling, resulting in overgrowth of poorly organized bone. (bmj.com)
  • Talk with your family doctor or provider if you suspect your child may have an endocrine disorder. (mainehealth.org)
  • Nearly one in 10 older adults in the U.S. has the disorder , according to the Centers for Disease Control and Prevention. (livescience.com)
  • Though osteoporosis is often thought of as strictly a bone disorder, it often falls under the treatment of endocrinologists because of its underlying causes. (livescience.com)
  • Diabetes - a disease in which the pancreas stops producing insulin, the hormone that regulates blood sugar levels - is the most common endocrine disorder in the U.S., affecting about 8 percent of the population, according to the National Institute of Diabetes and Digestive and Kidney Diseases. (livescience.com)
  • History of an endocrine or metabolic disorder (e.g. (hss.edu)
  • Thyrotoxic bone disease in women: a potentially reversible disorder. (semanticscholar.org)
  • This dwarfism type is caused by an endocrine disorder and not a skeletal dysplasia. (wikipedia.org)
  • The hormone produced by the thyroid gland has big impact on bone density, blood calcium levee. (wikipedia.org)
  • Abnormalities of the thyroid gland impact bone disease such as osteoporosis, a condition that is common in women but men can be diagnosed with this silent disease as well as it mainly affects elderly individual. (wikipedia.org)
  • The progressive systemic disease, the post-operative complications, and the pre-operative neurologic impairment were associated to a worst global survival rate in the thyroid cancer. (clinicaltrials.gov)
  • I remember her telling me during my last visit that too much thyroid hormone can cause osteoperosis, and a eating away of the bones. (dailystrength.org)
  • An important clue to the presence of thyroid disease in an elderly patient is a history of thyroid disease in another close family member such as a brother, sister or child of the patient. (thyroid.org)
  • During therapy, the effects of change in thyroid function on other body systems must be closely monitored, due to an increased likelihood of co-existing cardiac, central nervous system and thyroid disease in older patients. (thyroid.org)
  • They are also active in extensive research, particularly with respect to diabetes and thyroid diseases. (montefiore.org)
  • Identify and manage some of the nosological entities that endocrinologists are called upon for diagnosis and treatment (i.e., normocalcemic hyperparathyroidism, Paget's disease, adult forms of osteogenesis imperfecta, fibrous dysplasia of bone, etc. (endocrine.org)
  • Paget's disease of bone is common, affecting up to 4% of Australians over the age of 55 years. (mja.com.au)
  • The cause of Paget's disease is unknown, but there is a strong genetic influence. (mja.com.au)
  • Recently, mutations in the sequestosome 1/p62 gene have been identified as a cause of familial Paget's disease and of some apparently sporadic cases of the disease. (mja.com.au)
  • Paget's disease is eminently treatable. (mja.com.au)
  • Paget's disease predominantly affects the elderly. (mja.com.au)
  • 5 Recent studies from the United Kingdom and New Zealand suggest that the incidence of Paget's disease is falling, perhaps by as much as 50% over the past 20 years, and that the severity of newly diagnosed cases is falling. (mja.com.au)
  • The cause of Paget's disease is unknown. (mja.com.au)
  • 8 , 9 Genome linkage scans have identified several loci associated with familial Paget's disease. (mja.com.au)
  • 13 , 14 Mutations in the SQSTM1/p62 gene are therefore a plausible cause of Paget's disease, but it is unclear how germline DNA mutations (present in every osteoclast) cause bone disease that is focal in nature. (mja.com.au)
  • 15 Presumably, the declining incidence of Paget's disease reflects a decline in one or more as yet unidentified environmental influences. (mja.com.au)
  • Paget's disease presents clinically in a variety of ways ( Box 1 ), depending in part on the bones affected. (mja.com.au)
  • Paget's disease of bone (commonly known as Paget's disease or historically, osteitis deformans) is a condition involving cellular remodeling and deformity of one or more bones. (wikipedia.org)
  • Paget's disease may affect any one or multiple bones of the body (most commonly pelvis, femur, and lumbar vertebrae, and skull), but never the entire skeleton, and does not spread from bone to bone. (wikipedia.org)
  • Rarely, a bone affected by Paget's disease can transform into a malignant bone cancer. (wikipedia.org)
  • As the disease often affects people differently, treatments of Paget's disease can vary. (wikipedia.org)
  • Paget's disease affects from 1.5 to 8.0 percent of the population, and is most common in those of British descent. (wikipedia.org)
  • Mild or early cases of Pagets are asymptomatic, and so most people are diagnosed with Paget's disease incidentally during medical evaluation for another problem. (wikipedia.org)
  • Approximately 35% of patients with Paget's have symptoms related to the disease when they are first diagnosed. (wikipedia.org)
  • Paget's may first be noticed as an increasing deformity of a person's bones. (wikipedia.org)
  • Paget's disease affecting the skull may lead to loss of hearing in one or both ears due to compression of the nerves in the inner ear. (wikipedia.org)
  • Paget's disease is a frequent component of multisystem proteinopathy. (wikipedia.org)
  • Advanced Paget's disease may lead to other medical conditions, including: Osteoarthritis may result from changes in bone shape that alter normal skeletal mechanics. (wikipedia.org)
  • Heart failure is a rare, reported consequence of severe Paget's disease (i.e. more than 40% skeletal involvement). (wikipedia.org)
  • Kidney stones are somewhat more common in patients with Paget's disease. (wikipedia.org)
  • Nervous system problems may occur in Paget's disease, resulting from increased pressure on the brain, spinal cord, or nerves, and reduced blood flow to the brain and spinal cord. (wikipedia.org)
  • When Paget's disease affects the facial bones, the teeth may become loose. (wikipedia.org)
  • Paget's disease is not associated with osteoporosis. (wikipedia.org)
  • Despite their marked differences, several treatments for Paget's disease are also used to treat osteoporosis. (wikipedia.org)
  • Paget's disease may be caused by a slow virus infection (i.e., paramyxoviridae) present for many years before symptoms appear. (wikipedia.org)
  • Laboratory contamination may have played a role in past studies linking paramyxovirus (e.g. measles) to Paget's disease. (wikipedia.org)
  • There is a hereditary factor in the development of Paget's disease of bone. (wikipedia.org)
  • Two genes, SQSTM1 and RANK, and specific regions of chromosome 5 and 6 are associated with Paget's disease of bone. (wikipedia.org)
  • Genetic causes may or may not involve a family history of Paget's disease. (wikipedia.org)
  • About 40-50% of people with the inherited version of Paget's disease have a mutation in the gene SQSTM1, which encodes a protein, called p62, that is involved in regulating the function of osteoclasts (bone cells). (wikipedia.org)
  • Paget's disease of bone is associated with mutations in RANK. (wikipedia.org)
  • Paget's disease of bone (PDB) was originally described in a report that has become a classic in the medical literature. (springer.com)
  • Paget's disease occurs most commonly in people of British descent. (springer.com)
  • Paget's disease is the second most common bone remodeling disease after osteoporosis, occurring in 1%-2% of white adults older than 55. (aace.com)
  • citation needed] Paget's disease affecting the skull may cause frontal bossing, increased hat size, and headaches. (wikipedia.org)
  • For other diseases named after Paget, see Paget's disease (disambiguation) . (wikipedia.org)
  • The findings probably correspond to the "cotton wool spots" seen on plain films in the later stages of Paget's disease. (wikipedia.org)
  • Michael Baum, emeritus professor of surgery at University College London, suggested that the sitter had Paget's disease of bone. (wikipedia.org)
  • Pituitary and other endocrine tumour samples will be collected at surgery and kept in liquid nitrogen or −80 C. They will be coded with unique ID numbers. (clinicaltrials.gov)
  • The first gene we wish to study causes familial acromegaly, a disease resulting from a pituitary adenoma secreting growth hormone. (clinicaltrials.gov)
  • Individuals with paralysis after SCI will have large declines in their bone density ant increases in fat mass which increases their risk of fracture and heart disease. (clinicaltrials.gov)
  • Hypothesis: Among adults with SCI for a long time, treatment with a drug named Rosuvastatin or a sugar pill, with supplements (coenzyme Q10, calcium and vitamin D), for twelve months can decrease their endocrine metabolic disease risk by increasing bone density and reducing inflammation. (clinicaltrials.gov)
  • Data Collected: Subjects' bone density will be collected at the start and end of the study. (clinicaltrials.gov)
  • Change in bone density between the two groups will be compared to see if one is better. (clinicaltrials.gov)
  • Rationale: Individuals with motor-complete spinal cord injury (SCI) undergo dramatic changes in body composition in the first 18 months post-injury, including declines in bone mineral density (BMD) that increase lower-extremity fragility fracture risk, and increases in fat mass that increase cardio-metabolic disease (CMD) risk. (clinicaltrials.gov)
  • She is currently the Director of the MGH Bone Density Center and Assistant Professor in Medicine at Harvard Medical School. (massgeneral.org)
  • Patients with thalassemia major (TM) have a lower bone mineral density (BMD) and higher risk of fracture than the general population. (nih.gov)
  • Osteoporosis results from a loss of bone mass (measured as bone density) and from a change in bone structure. (rheumatology.org)
  • A simple test known as a bone density scan, or DEXA, can give important information about your bone health. (rheumatology.org)
  • Because Osteoporosis is silent, the bone density test, or DEXA, has become of major importance. (rheumatology.org)
  • Just found out on Friday that my Doctor has submitted a referral for me to get a bone density scan. (dailystrength.org)
  • More than 8 million of the 44 million Americans who have either osteoporosis or low bone mineral density (BMD) are men. (aace.com)
  • Bone mineral density determinations by dual-energy-x-ray absorptiometry in the management of patients with Marfan syndrome - some factors which affect the measurement. (scielo.org.za)
  • Radiographic damage associated with low bone mineral density and vertebral deformities in rheumatoid arthritis: the Oslo-Truro-Amsterdam (OSTRA) collaborative study. (springer.com)
  • Low bone density - lower than normal levels of minerals in your bones - cause your bones to become thin, weak and fragile. (stormontvail.org)
  • Endocrinologists work with patients who have very abnormal bone density test results. (stormontvail.org)
  • Bone X-rays, meanwhile, will reveal decreased bone density and other bone- and joint-related abnormalities. (petmd.com)
  • She is certified in clinical densitometry and interprets bone density studies in the evaluation of osteoporosis. (mssm.edu)
  • Prevalence of subclinical contributors to low bone mineral density and/or fragility fracture. (semanticscholar.org)
  • Other complications of Paget disease of bone depend on which bones are affected. (medlineplus.gov)
  • The disease is often asymptomatic, but can cause bone pain, deformity, fracture and other complications. (mja.com.au)
  • 1 The disease results in bone expansion and structural weakness, which can cause pain, deformity, and a range of complications. (mja.com.au)
  • In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
  • SSEs often occur in women with oestrogen-receptor-positive advanced breast cancer and the associated complications have a substantial disease and economic burden. (springer.com)
  • Clinical endocrinologists worldwide rely on Endocrine Practice, the official journal of the American Association of Clinical Endocrinologists (AACE), to keep them on the leading edge of treatment of patients with endocrine diseases. (aace.com)
  • Image-guided percutaneous radiofrequency ablation and cryoablation techniques have been studied in clinical trials and are considered effective options in pain palliation of patients with bone metastatic disease. (clinicaltrials.gov)
  • Clinical Implications: Statins may be safe and effective therapy for adults living with SCI who are at increased risk of endocrine metabolic disease as they age. (clinicaltrials.gov)
  • Elaine W. Yu, MD, MMSc is a clinical researcher and endocrinologist in the Endocrine Unit at the Massachusetts General Hospital (MGH). (massgeneral.org)
  • With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information accessible for clinical interventions. (wiley-vch.de)
  • i) Training our fellows, residents and students in the identification and management of endocrine abnormalities developing in patients who have been diagnosed with and treated for neoplasms and/or who have received HSCT at the NIH-Clinical center. (knowcancer.com)
  • ii) Developing new clinical studies for the recognition and therapy of endocrine side effects related to cancer therapy and/or HSCT: this protocol will eventually lead to new, separate protocols that will address specific aspects of endocrinopathies in childhood cancer survivors and HSCT survivors. (knowcancer.com)
  • It is the best journal to keep up to date with endocrine pathophysiology both in the clinical and in the research field. (elsevier.es)
  • She is a member of the Board of Directors of the American Association of Clinical Endocrinologists and is on the editorial board of Endocrine Practice and Journal of Clinical Densitometry . (endocrineweb.com)
  • Clinical features and diagnosis of celiac disease. (scielo.org.za)
  • Biochemical markers for bone turnover for the clinical assessment of metabolic bone disease. (scielo.org.za)
  • Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, disease-modifying properties, and side effects: a randomized, double-blind, placebo-controlled clinical trial. (springer.com)
  • In contrast, Osteoblast promotes calcium absorption by the bone therefore, promoting bone mineralization and formation of new bones. (wikipedia.org)
  • In fact, Vitamin D is needed for efficient absorption of calcium and therefore proper bone health. (wikipedia.org)
  • Osteomalacia is the softening of bones due to poor bone mineralization which is in turn due to poor calcium absorption. (wikipedia.org)
  • abnormalities of specific organs involved, deficiency in vitamin D or low Calcium in diet, which results in poor bone mineralization. (wikipedia.org)
  • The Metabolic Bone Disease & Endocrine Calcium Center addresses problems associated with the regulation of the body's bone, mineral and hormone functions. (clevelandclinic.org)
  • Hypothesis: Twelve months of statin therapy with concurrent coenzyme Q10 (CoQ10), to reduce risk of statin neuromyotoxicity, and standard care (calcium 1250mg OD and vitamin D3 2000IU OD) will be superior to placebo with CoQ10 and standard care, for augmenting knee region BMD and reducing inflammatory stress (hs-CRP), thereby reducing endocrine metabolic disease risk. (clinicaltrials.gov)
  • D is the vitamin that allows calcium to be absorbed into the bones. (dailystrength.org)
  • A calcium-binding substance produced by osteoblasts that is essential to bone mineralization and can be used as a biomarker for osteoporosis. (thefreedictionary.com)
  • A gene on chromosome 1q25-q31 that encodes a protein which constitutes 1-2% of bone protein, which binds strongly to apatite and calcium. (thefreedictionary.com)
  • n vitamin Kdependent calcium-binding protein synthesized by osteoblasts and found primarily in bone. (thefreedictionary.com)
  • Each case study reviews how the patient was managed, details the reasons why various tests and treatments-many only recently available-were carried out, and provides references to ensure that those novel methodologies can be easily translated into the endocrine specialist's daily practice. (barnesandnoble.com)
  • The diseases caused by either the deficiency or excessive of hormones is known as endocrine diseases. (tutorialspoint.com)
  • The endocrine system is a group of glands and cells that make hormones, which are released into your blood. (stormontvail.org)
  • The body's hormones, and the glands that produce them, make up the endocrine system . (livescience.com)
  • Here are 11 interesting facts that may surprise you about the endocrine system, its glands and its hormones. (livescience.com)
  • The new term sparked intense research on the endocrine system in the first half of the 20th century, and scientists fervently worked to identify and understand the various hormones in the body. (livescience.com)
  • Not all hormones come from the endocrine system. (livescience.com)
  • But some other organs and tissues that are not generally considered part of the endocrine system also produce and secrete hormones. (livescience.com)
  • Many people with classic Paget disease of bone do not experience any symptoms associated with their bone abnormalities. (medlineplus.gov)
  • and other diseases (idiopathic male osteoporosis, corticosteroid-induced osteoporosis) produce abnormalities in the material composition and structure that lead to bone fragility. (fluoridealert.org)
  • Despite the increased bone tissue mass, the bone strength is reduced due to several abnormalities in mineral. (fluoridealert.org)
  • Genetic syndromes and familial inheritance patterns with endocrine abnormalities ix. (slideshare.net)
  • Thus, with growing knowledge of the pathways regulating osteoclast function and the appreciation that some of these are active also in tumor cells, drug companies have made efforts to identify small-molecular lead compounds for development into new therapeutic agents for the prevention of bone loss with efficacy that matches or supersedes that of bisphosphonates. (aacrjournals.org)
  • Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic mice. (springer.com)
  • These structural changes cause the bone to weaken, which may result in deformity, pain, fracture, or arthritis of associated joints. (wikipedia.org)
  • Newer medications can slow and even stop the progression of bones getting weaker, and can help decrease fracture risk. (rheumatology.org)
  • Symptomatic patients typically experience pain localized to the bone or joint, either from the pagetic lesion, secondary osteoarthritis, deformity, or pathological fracture. (bmj.com)
  • Fracture care: Certain endocrine diseases, such as osteoporosis, can increase your risk of breaking bones. (stormontvail.org)
  • Insights into material and structural basis of bone fragility from diseases associated with fractures: how determinants of the biomechanical properties of bone are compromised by disease. (fluoridealert.org)
  • Minimal trauma fractures in bone diseases are the result of bone fragility. (fluoridealert.org)
  • By doing so, you can avoid the often-disabling broken bones (fractures) that can result from this condition. (rheumatology.org)
  • This results in hypercalcemia, which can lead to muscle aches, osteoporosis, abdominal pain, kidney stones and bone fractures. (providence.org)
  • Osteoporosis is a common disease in aging people, and makes bones less dense and more prone to fractures. (livescience.com)
  • Fluoride is incorporated into the crystalline lattice of hydroxyapatite, making the lattice more stable and less soluble and increasing the crystallinity of the bone mineral. (fluoridealert.org)
  • In addition, fluoride alters the interface between mineral and collagen that may influence the mechanical properties of bone (80). (fluoridealert.org)
  • He is a charter member of the American Society for Bone and Mineral Research and for the past 30 years has been broadly involved in the development of strategies to prevent and treat osteoporosis. (mdanderson.org)
  • OBJECTIVE To measure changes in spinal and femoral neck bone mineral densities in patients treated for Graves thyrotoxicosis. (semanticscholar.org)
  • The annual Endocrine Fellows Series: Osteoporosis and Metabolic Bone Diseases is a CME-certified conference of pediatric and adult endocrine fellows held in conjunction with the Santa Fe Bone Symposium (August 3-4,2018) in Santa Fe, New Mexico. (endocrine.org)
  • Within the bone field, my ongoing research projects include (1) studying skeletal health after bariatric (weight loss) surgery in obese patients, (2) determining the physiologic mechanisms involved in bone loss after bariatric surgery, and (3) using these insights to guide management of bone health in bariatric surgery patients. (massgeneral.org)
  • Fairly absolute indications for surgery include moderate or severe eye disease in Graves' disease, large goiter with compressive symptoms, any suspicion of cancer, and pregnant patients or those wanting to become pregnant in the next one to two years. (providence.org)
  • Delayed puberty due to chronic disease or anorexia nervosa v. Exogenous obesity vi. (slideshare.net)
  • Endocrine and genetic causes of obesity viii. (slideshare.net)
  • Plant-based proteins are much better sources of protein, fiber, and the other vitamins and nutrients that help your hormone health and balance your endocrine system. (juicing-for-health.com)
  • We may prescribe hormone supplements for diseases such as hypothyroidism or adrenal insufficiency. (stormontvail.org)
  • Enpp1 −/− mice had increased levels of the insulin-sensitizing bone-derived hormone osteocalcin but unchanged insulin signalling within osteoblasts. (biologists.org)
  • In particular, postmenopausal women sometimes develop the disease because of their low levels of the hormone estrogen, which helps to maintain bone mass. (livescience.com)
  • The Osteoporosis & Bone Clinic focuses on the treatment and prevention of a wide range of skeletal issues caused by osteoporosis. (clevelandclinic.org)
  • Skeletal fluorosis results from a prolonged ingestion of fluoride causing bone pain, stiffness, and rigidity and possible deformities of the spine and limbs (69). (fluoridealert.org)
  • Metabolic bone disease including rickets and skeletal dysplasias xii. (slideshare.net)
  • Metabolic diseases affecting bone are generally diagnosed late when patients present clinically with end stage skeletal debilitation. (scielo.org.za)
  • Osteoarthritis may result from changes in bone shape that alter normal skeletal mechanics. (wikipedia.org)
  • Bone remodelling is a highly conserved and regulated process that controls bone homeostasis and maintains skeletal structural integrity. (biologists.org)
  • Part I: Metabolic bone disease: histomorphometry as a diagnostic aid. (scielo.org.za)
  • Osteopaenia and osteo-malacia after gastrectomy: interrelations between biochemical markers of bone remodeling, vitamin D metabolites and bone histomorphometry. (scielo.org.za)
  • This manuscript presents histomorphometry as a quantifiable method for the accurate assessment of metabolic bone disease at cellular level. (scielo.org.za)
  • 2. Steinche T. Bone histomorphometry in the pathophysiological evaluation of primary and secondary osteoporosis and various treatment modalities. (scielo.org.za)
  • At the end of the treatment, bone structure was analyzed by histomorphometry. (springer.com)
  • Serum bone GLA protein compared to bone histomorphometry in endocrine diseases. (thefreedictionary.com)
  • Individuals receiving a bone marrow. (clinicaltrials.gov)
  • Individuals receiving a bone marrow transplant at one of 10 study locations, between March 2012 and June, 2015. (clinicaltrials.gov)
  • This bone marrow film at 400X magnification demonstrates a complete absence of hemopoietic cells. (medscape.com)
  • In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
  • [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
  • These data reinforce the need for marked vigilance in ensuring proper screening and management of long-term survivors of bone marrow transplantation. (medscape.com)
  • Key bone techniques that I am utilizing include high-resolution peripheral quantitative computed tomography (HR-pQCT) for the in vivo assessment of bone microarchitecture, microindentation for the estimation of cortical bone material strength properties, and 1H-magnetic resonance spectroscopy for the measurement of marrow adiposity characteristics. (massgeneral.org)
  • Endocrine dysfunction is increasingly recognized as one of the most important aspects of quality of life issues, physical and psychosocial development and overall prognosis in pediatric patients diagnosed with neoplasms as well as in patients s/p bone marrow transplant throughout their lifespan. (knowcancer.com)
  • Compare the efficacy of processed (cell depleted) vs unprocessed (conventional) unrelated bone marrow transplantation in reducing grade III/IV acute graft vs host disease (GVHD) in patients with acute or chronic leukemia or myelodysplastic syndromes. (knowcancer.com)
  • Patients are randomized to one of two bone marrow transplantation arms. (knowcancer.com)
  • Bone marrow is infused on day 0. (knowcancer.com)
  • Arm I: Patients receive allogeneic bone marrow that has been processed to produce a mononuclear cell preparation. (knowcancer.com)
  • Arm II: Patients receive unprocessed allogeneic bone marrow. (knowcancer.com)
  • Fine needle aspirates (liquids) from the lymph nodes and bone marrow can be used for diagnoses of lymphoma , or cancer of the blood. (petmd.com)
  • Here, we report that p27 Kip1 plays a major role in cardiovascular disease through its effects on the proliferation of bone marrow-derived (BM-derived) immune cells that migrate into vascular lesions. (jci.org)
  • Your pet's veterinarian will also take a sample from other body sites and organs -- such as the liver, bone marrow, joints, and lymph nodes -- for further analysis. (petmd.com)
  • Particularly, studies of human and animal genetics have led to identification of novel, more specific, signaling pathways in bone cells that can provide targets for new therapeutics. (endocrine-abstracts.org)
  • Endocrinologists are medical doctors (MD) or doctor of osteopathic medicine (DO) who treat people with ailments of the endocrine system. (castleconnolly.com)
  • Endocrine and Metabolic Medical Emergencies: A Clinician's Guide provides a singular reference to help endocrinologists, acute and general medicine clinicians, hospitalists and critical care physicians, and general practitioners recognize the symptoms of endocrine emergencies and provide the highest standards of care. (wiley.com)
  • At Providence, our endocrinologists, radiologists, and endocrine surgeons work in partnership to provide personalized attention to your endocrine health. (providence.org)
  • Mineralization defects are present in calcified tissue or around the osteocytic lacunae (Fig. 5B), and some area of woven bone may be observed but the bone texture is mainly lamellar (74). (fluoridealert.org)
  • Some modifications of the amino acid composition of collagen (decreased hydroxyproline and lysine residues, increased proline residues) and of collagen cross-links disturb the mineralization process and consequently reduce the bone strength (75). (fluoridealert.org)
  • The emergence of bone as an endocrine regulator has prompted a re-evaluation of the role of bone mineralization factors in the development of metabolic disease. (biologists.org)
  • Ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) controls bone mineralization through the generation of pyrophosphate, and levels of NPP1 are elevated both in dermal fibroblast cultures and muscle of individuals with insulin resistance. (biologists.org)
  • Most of these have been studied in patients with osteoporosis and not in those with metastatic bone disease. (aacrjournals.org)
  • These magnesium-rich nuts and seeds help stabilize insulin levels and lower cortisol levels which can shock your endocrine system if too high. (juicing-for-health.com)
  • The abnormal bone formation is associated with recruitment of abnormal blood vessels, forcing the cardiovascular system to work harder (pump more blood) to ensure adequate circulation. (wikipedia.org)
  • GOAL : Normal Versus Abnormal (Endocrine). (slideshare.net)
  • Many involve joint pain caused by abnormal bone alignment, or from nerve compression. (wikipedia.org)
  • Different epidemiological studies show the relationship between osteoporosis, cardiovascular disease, and cardiovascular-related mortality. (elsevier.es)
  • Además, recientemente se han producido diversos avances en el conocimiento de la relación entre metabolismo óseo y metabolismo energético, lo que pudiera tener implicaciones en la patología cardiovascular. (elsevier.es)
  • The relationship between osteoporosis, cardiovascular disease, and mortality associated to the latter has previously been reported. (elsevier.es)
  • His major interest in this role is in the prevention of atherosclerotic cardiovascular disease, such as heart attacks, strokes and peripheral vascular disease. (mountsinai.org)
  • However, for individuals with diabetes, cardiovascular disease (CVD) remains the main problem. (diabetesjournals.org)
  • A rare type of bone cancer called osteosarcoma has been associated with Paget disease of bone. (medlineplus.gov)
  • This type of cancer probably occurs in less than 1 in 1,000 people with this disease. (medlineplus.gov)
  • Radiograph and ultrasound imaging can also be used for diagnosing underlying conditions, such as kidney disease, bladder stones, or cancer. (petmd.com)
  • Prevalence of Secondary Causes of Bone Loss Among Breast Cancer Patients with Osteopenia and Osteoporosis. (endocrineweb.com)
  • 4. Guise TA, Mundy GR. Cancer and bone. (scielo.org.za)
  • The delayed diagnosis complicates effective therapy, and both forms of chronic pancreatitis (CP) result in severe disability, lifelong metabolic disease, and a high risk of pancreatic cancer. (nih.gov)
  • To establish if the candidate gene is also causing possibly sporadic (not familial) cases of the disease, samples (blood and tissue) will be collected from patients with sporadic disease and will be analysed as above. (clinicaltrials.gov)
  • iii) The protocol will serve as the basis for outpatient clinics that will function within the context of the pediatric and adult endocrine outpatient clinics: every eligible patient referred to the endocrine service from the NCI, NHLBI, and other NIH institutions and centers will be enrolled in this study, which for the first time will create an endocrine database for these patients. (knowcancer.com)
  • Since then, our understanding of the regulation of bone catabolism has advanced significantly with the identification of other key enzymes that regulate osteoclast formation, activation, and survival after their knockout in mice or recognition of mutations in them in humans. (aacrjournals.org)
  • Complicated feedback loops are involved in intricate regulation of virtually all body functions through the endocrine system. (slideshare.net)
  • We combine in vivo genetic mouse models with in vitro tissue culture and molecular biology techniques to better understand the role of specific signaling pathways and transcription factors in regulation of bone and joint development as well as in the onset and progression of osteoarthritis. (rochester.edu)
  • The regulation of theca cell-granulosa cell dialogue by endocrine and paracrine factors 19. (bookdepository.com)
  • We will recruit patients from our own Endocrine outpatient clinics and inpatient wards. (clinicaltrials.gov)
  • Goal: To acquire and demonstrate the fund of knowledge and practical skills necessary to manage common and complex pediatric endocrine conditions in infants, children, and adolescents. (slideshare.net)
  • Treatment varies for each different type of pediatric endocrine issue. (mainehealth.org)
  • Estrogen deficiency is responsible for a number of bone diseases such as osteoporosis. (ecochildsplay.com)
  • In addition, group discussion sessions provide case-based practical strategies on the diagnosis and treatment of patients with osteoporosis and metabolic bone diseases. (endocrine.org)
  • Among her many professional memberships, Prof. Brandi is Past President of S.I.O.M.M.M.S. (Italian Society of Osteoporosis and Metabolic Bone Diseases), General Secretary of ESCEO, and Executive Director of the OrtoMed Society. (iofbonehealth.org)
  • Prof. Brandi has won many honors and awards, and is a Past President of SIOMMMS (the Italian Society of Osteoporosis and Metabolic Bone Diseases), General Secretary of ESCEO, and Executive Director of the OrtoMed Society. (foyles.co.uk)
  • The characteristics of osteoporotic patients in Graves' disease patients newly diagnosed after menopause: a prospective observational study. (semanticscholar.org)
  • Kwashiorkor-Marasmus syndrome and nutritional rickets - a bone biopsy study. (scielo.org.za)
  • 17. Raubenheimer EJ, van Heerden WFP, Potgieter D. Static and dynamic bone changes in hospitalized patients suffering from rickets - a histomorphometric study. (scielo.org.za)
  • The relationship between bone-related proteins such as osteocalcin and osteoprotegerin and vascular disease is of special interest. (elsevier.es)
  • Determination of bone Gla protein (osteocalcin) by enzyme-linked immunosorbent assay. (thefreedictionary.com)
  • Osteocalcin or bone Gla protein (BGP) is a vitamin K-dependent, low-molecular-mass (5800 Da), 49 amino acid peptide synthesized by osteoblasts [1, 2]. (thefreedictionary.com)
  • She was a Visiting Scientist in Metabolic Diseases, Metabolic Diseases Branch, NIH, Bethesda, Maryland, and additionally earned a Ph.D. in Cell Biology at the University of Rome. (iofbonehealth.org)
  • Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. (bireme.br)
  • Liver, Biliary Tract and Pancreatic Disease 8. (okian.ro)
  • The endocrine system does a lot of work, and works hard, so how can we help it? (juicing-for-health.com)
  • The book contains 19 chapters that are arranged by organ system and structured to cover the specific areas for a quick but in-depth understanding of diseases in aging patients. (springer.com)
  • Every time you grow, sleep, or feel hunger pains, you have your endocrine system to thank. (stormontvail.org)
  • The risk of circulatory diseases was established to account of 2.5 (95% CI 2.1-3.6), the infectious and parasitic diseases - 2.4 (95% CI 1.7-3.5), the endocrine system - 2,2 (95% CI 1.4-3.4), and urinary system - 2.3 (95% CI 1.7 to 3.0). (bireme.br)
  • Like the nervous system, the endocrine system is an information signal system. (livescience.com)
  • The endocrine system is sometimes at fault for osteoporosis. (livescience.com)
  • In bone from fluoride-treated osteoporotic women and fluorotic patients, xray scattering shows crystals too large to be located inside the collagen fibrils (79). (fluoridealert.org)
  • The DEXA scan can tell you if your bone is becoming osteoporotic. (rheumatology.org)
  • The PTH paradigm illustrated the possibility of stimulating bone formation in osteoporotic patients and opened the way for the development of bone forming agents and novel forms of PTH (e.g. (endocrine-abstracts.org)
  • While statins are an effective treatment for dyslipidemia, research evidence suggests additional pleiotropic effects on bone through promotion of osteogenesis, suppression of osteoblast apoptosis, and inhibition of osteoclastogenesis. (clinicaltrials.gov)
  • src −/− mice formed increased numbers of osteoclasts, but the cells failed to resorb bone because they did not form ruffled borders ( 2 ), which severely limited their ability to resorb bone matrix. (aacrjournals.org)
  • For example, inhibition of this pathway by blocking the action of sclerostin represents a very promising novel approach to stimulating bone formation in patients with osteoporosis. (endocrine-abstracts.org)
  • 13. Lee WT, Jiang J. The resurgence of the importance of vitamin D in bone health. (scielo.org.za)
  • Direct demonstration that the vitamin K-dependent bone Gla protein is incompletely [gamma]-carboxylated in humans. (thefreedictionary.com)
  • Diagnosis is incidental in the majority of patients, with an elevated serum alkaline phosphatase raising suspicion for disease. (bmj.com)
  • The Pharmaceutical Benefits Scheme subsidises treatment only for patients with symptomatic disease. (mja.com.au)
  • The femoral and lumbar compressive strength of fluoride-treated rats is lower than controls (70, 71), and the fluoride treatment increases BMD in ovariectomized rats but decreases bone strength and stiffness (72). (fluoridealert.org)
  • Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment. (rochester.edu)
  • Symptoms and treatment for kidney disease vary depending the specifics of the case, but oftentimes, a diet change can help. (petmd.com)
  • Dexamethasone monotherapy substantially suppressed joint swelling without inhibiting bone loss of the secondary spongiosa, whereas OPG monotherapy showed no anti-inflammatory effect. (springer.com)
  • In contrast, the combination of dexamethasone and OPG not only produced an anti-inflammatory effect, but also resulted in inhibition of periarticular and axial bone loss. (springer.com)
  • Neurological symptoms due to bone overgrowth with consequent nerve impingement may include hearing loss, chronic facial pain, hydrocephalus, peripheral nerve entrapment, and spinal stenosis. (bmj.com)
  • Lifestyle intervention (physical and nutritional) is critical to successful management of virtually every endocrine and metabolic disease. (castleconnolly.com)
  • The research is aimed at identifying new predisposition genes for endocrine tumours. (clinicaltrials.gov)