Bone and Bones
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
Endocrine System Diseases
Endocrine Gland Neoplasms
Tumors or cancer of the ENDOCRINE GLANDS.
Exogenous agents, synthetic and naturally occurring, which are capable of disrupting the functions of the ENDOCRINE SYSTEM including the maintenance of HOMEOSTASIS and the regulation of developmental processes. Endocrine disruptors are compounds that can mimic HORMONES, or enhance or block the binding of hormones to their receptors, or otherwise lead to activating or inhibiting the endocrine signaling pathways and hormone metabolism.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Dissolution of bone that particularly involves the removal or loss of calcium.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
Bone Marrow Cells
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Osteitis Fibrosa Cystica
A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
Bone Density Conservation Agents
A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.
A VITAMIN D that can be regarded as a reduction product of vitamin D2.
Multiple Endocrine Neoplasia Type 1
A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).
Bone Marrow Transplantation
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Bone Diseases, Endocrine
Diseases of the bones related to hyperfunction or hypofunction of the endocrine glands.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Multiple Endocrine Neoplasia
A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are MEN1 and MEN2 with gene mutations on CHROMOSOME 11 and CHROMOSOME 10, respectively.
Abnormally high level of calcium in the blood.
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
Bone Morphogenetic Proteins
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Stable strontium atoms that have the same atomic number as the element strontium, but differ in the atomic weight. Sr-84, 86, 87, and 88 are the stable strontium isotopes.
Fibrous Dysplasia of Bone
A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).
Technetium Tc 99m Medronate
A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
Receptor Activator of Nuclear Factor-kappa B
A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.
Multiple Endocrine Neoplasia Type 2a
A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
Calcium Metabolism Disorders
Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.
Bone Morphogenetic Protein 2
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
Kidney Failure, Chronic
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
Collagen Type I
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.
COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.
A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
Cells found throughout the lining of the GASTROINTESTINAL TRACT that contain and secrete regulatory PEPTIDE HORMONES and/or BIOGENIC AMINES.
Multiple Endocrine Neoplasia Type 2b
Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
Alveolar Bone Loss
Excision of one or more of the parathyroid glands.
Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.
Islets of Langerhans
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.
Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.
A condition of an abnormally low level of PHOSPHATES in the blood.
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
Antineoplastic Agents, Hormonal
Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
Disease Models, Animal
Medullary Sponge Kidney
A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.
A subspecialty of internal medicine concerned with the metabolism, physiology, and disorders of the ENDOCRINE SYSTEM.
Mesenchymal Stromal Cells
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Tomography, X-Ray Computed
Monoclonal Gammopathy of Undetermined Significance
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
The bone that forms the frontal aspect of the skull. Its flat part forms the forehead, articulating inferiorly with the NASAL BONE and the CHEEK BONE on each side of the face.
Core Binding Factor Alpha 1 Subunit
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
Bone Morphogenetic Protein 7
A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.
Phosphorus Metabolism Disorders
Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.
PHEX Phosphate Regulating Neutral Endopeptidase
A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.
Pathologic deposition of calcium salts in tissues.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Receptors, Tumor Necrosis Factor
A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.
Adenoma, Islet Cell
A benign tumor of the pancreatic ISLET CELLS. Usually it involves the INSULIN-producing PANCREATIC BETA CELLS, as in INSULINOMA, resulting in HYPERINSULINISM.
Receptors, Cytoplasmic and Nuclear
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
Reverse Transcriptase Polymerase Chain Reaction
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Vitamin D Deficiency
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.
Acidosis, Renal Tubular
A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
Dose-Response Relationship, Drug
Bone Marrow Neoplasms
A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.
Bone Marrow Examination
Removal of bone marrow and evaluation of its histologic picture.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Fractures of the femur.
A GASTRIN-secreting neuroendocrine tumor of the non-beta ISLET CELLS, the GASTRIN-SECRETING CELLS. This type of tumor is primarily located in the PANCREAS or the DUODENUM. Majority of gastrinomas are malignant. They metastasize to the LIVER; LYMPH NODES; and BONE but rarely elsewhere. The presence of gastrinoma is one of three requirements to be met for identification of ZOLLINGER-ELLISON SYNDROME, which sometimes occurs in families with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; (MEN 1).
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A group of acidic proteins that are major components of SECRETORY GRANULES in the endocrine and neuroendocrine cells. They play important roles in the aggregation, packaging, sorting, and processing of secretory protein prior to secretion. They are cleaved to release biologically active peptides. There are various types of granins, usually classified by their sources.
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Parathyroid Hormone-Related Protein
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.
A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
Bone Morphogenetic Protein 4
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Cell Line, Tumor
A cell line derived from cultured tumor cells.
The five long bones of the METATARSUS, articulating with the TARSAL BONES proximally and the PHALANGES OF TOES distally.
A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Vitamin D receptor activators can protect against vascular calcification. (1/1)(+info)
Sebastian Meier - Research Output - DTU Research Database
Shunmugavel, S., Tosi, I., H. Rasmussen, K., E. Jensen, R., Taarning, E., Meier, S. & Riisager, A., 2016. 1 p.. Research output: Contribution to conference › Conference abstract for conference › Research › peer-review ...
September 2007). "Bone metastases of differentiated thyroid cancer: impact of early 131I-based detection on outcome". Endocrine ... ISBN 1-4051-0386-8. Rosen CJ (2008-11-18). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. John ... Any increased physiological function, such as a fracture in the bone, will usually mean increased concentration of the tracer. ... By chemically attaching technetium-99m to MDP, radioactivity can be transported and attached to bone via the hydroxyapatite for ...
Encyclopedia of Endocrine Diseases. Academic Press. 2018. p. 344. ISBN 9780128122006. "Office of Dietary Supplements - Vitamin ... Bringhurst F, Demay MB, Krane SM, Kronenberg HM (2008). "Bone and Mineral Metabolism in Health and Disease". In Fauci AS, ... Stimulating release of calcium from bone. For this it acts on the specific type of bone cells referred to as osteoblasts, ... It can be given as a medication for the treatment of low blood calcium and hyperparathyroidism due to kidney disease, low blood ...
"Nuclear Receptors in Bone Physiology and Diseases". Physiological Reviews. 93 (2): 481-523. doi:10.1152/physrev.00008.2012. ... "e.hormone , Endocrine System : Types of Hormones". e.hormone.tulane.edu. Retrieved 2017-04-06. "The Endocrine System". classes. ... Water-soluble hormones come from amino acids and are located and stored in endocrine cells until actually needed. The main two ... Deficiencies in nuclear receptor-mediated pathways play a key role in the development of disease, like osteoporosis. Water- ...
Osteoporosis is a type of bone disease characterized by a loss of bone density, mass and architecture that leaves a patient ... Endocrine: Cushingoid features, growth suppression in children, secondary adrenocortical and pituitary unresponsiveness, ... "Osteoporosis Overview , NIH Osteoporosis and Related Bone Diseases National Resource Center". www.bones.nih.gov. Retrieved 2020 ... Exogenous corticosteroids induce osteoporosis by increasing bone resorption and reducing bone formation. Bone loss can be ...
... may also lead to muscle weakness in the upper back and to arthritis and other bone-degeneration diseases. Because ... Camptocormia can lead to infection, tumors, and diseases of the endocrine system and connective tissues. The success of the ... BSS often appears in individuals afflicted with Parkinson's disease, muscular dystrophies, endocrine disorders, inflammatory ... and inflammatory muscle diseases; metabolic or endocrine disorders; and mitochondrial myopathies. A muscle biopsy can clearly ...
... a major risk-factor for veno-occlusive disease in the liver after allogeneic bone marrow transplantation". Blood. 92 (12): 4568 ... Trabert B, Sherman ME, Kannan N, Stanczyk FZ (April 2020). "Progesterone and Breast Cancer". Endocrine Reviews. 41 (2): 320-344 ... High-dose (10 mg/day) norethisterone has been associated with hepatic veno-occlusive disease, and because of this adverse ... Amory, John K. (2003). "Androgens and Male Contraception". Androgens in Health and Disease: 405-417. doi:10.1007/978-1-59259- ...
He has served as the President of the American Society for Bone and Mineral Research and the Endocrine Society. He was a member ... of the Board of Advisors of the Rolanette and Berdon Lawrence Bone Disease Program of Texas from 2006-2012. http://www. ... and studies that identified a role for parathyroid hormone in the regulation of the bone marrow stem cell niche. ... mouse models to understand the role of parathyroid hormone and parathyroid hormone-related protein in the regulation of bone ...
"A systematized approach to radiographic assessment of commonly seen genetic bone diseases in children: A pictorial review". J ... Endocrine Reviews. 21 (1): 23-39. doi:10.1210/edrv.21.1.0387. PMID 10696568. Aviezer, David; Golembo, Myriam; Yayon, Avner (30 ... The tubular bones are short and thick with metaphyseal cupping and flaring and irregular growth plates. Fibular overgrowth is ... Cartilage is not able to fully develop into bone, causing the individual to be disproportionately shorter in height. In normal ...
... the first to recognise the potential for bone marrow aspiration to be used as a technique for diagnosing hematological diseases ... Endocrine Today. Retrieved 28 September 2019. CS1 maint: discouraged parameter (link). ...
... a new endocrine organ at the heart of chronic kidney disease and mineral and bone disorders". The Lancet Diabetes & ... leading to low bone turnover or adynamic bone disease. Both high and low bone turnover diseases are currently observed equally ... Bone pain Joint pain Bone deformation Bone fracture The broader concept of chronic kidney disease-mineral and bone disorder ( ... "Adynamic bone disease: from bone to vessels in chronic kidney disease". Seminars in Nephrology. 34 (6): 626-40. doi:10.1016/j. ...
Michael F. Holick
"Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease". Am J Clin ... Holick honored by Endocrine Society". "BUSM professor receives 2011 ACN Communication Media Award". Institute of functional ... Holick made discoveries in the field of vitamin D that have led to novel therapies for metabolic bone diseases, hypocalcemic ... Jenifer McKim (March 13, 2015). "Boston University researcher draws fire for claiming some broken bones caused by rare disease ...
Osaka City University Hospital
Center for Lifestyle Diseases and Diabetes, Nephrology, Endocrinology, Bone and Arthritis Medicine, Gastroenterology, Hepato- ... Breast and Endocrine Surgery, Cardiovascular Surgery, Hepato-Biliary-Pancreatic Surgery, Respiratory Surgery, Pediatric Surgery ...
and other metabolic bone diseases. He has published over 400 scholarly articles and has delivered numerous prestigious ... the Gerald D Aurbach Lecture of the US Endocrine Society in 2009, the Wood lecturer, University of Calgary, Calgary, Alberta, ... He is the Director of the Centre for Bone and Periodontal Research and also holds the position of Senior Scientist at the ... He has been Director of the Centre for Advanced Bone and Periodontal Research, as well as Director of the Calcium Research ...
Kolling Institute of Medical Research
The Bone and Joint group investigates diseases of the bone, cartilage, tendons, ligaments and joints, with particular research ... ovary and endocrine organs, as well as regulation of normal body growth and bone metabolism. Research Focus Adrenal Lab Bill ... pregnancy and childbirth to cancer and genetics kidney and heart disease pain and neurological disorders diseases of bones and ... which contribute to the morbidity of bone and joint disease in the Australian community Apart from supporting research ...
... an endocrine disease, can present with enlargement of bones with growth potential such as the mandible, thickened soft tissues ... The surgery usually involves gaining access to the bone from inside the mouth, revealing and moving the bone into a correct ... Microgenia can be presented when there is inadequate bone depth at the apex of lower anteriors or the base of mandible and vice ... This is carried out to show the full degree of abnormality, and to create sufficient space for full correction in the bones. ...
Apollo Sugar Limited
... pituitary disease, adrenal gland disorder, pancreatic disease, PCOS, metabolic bone disease, and pediatric endocrinology. In ... Apollo Sugar Clinics provides treatment for type 1 diabetes, type 2 diabetes, gestational diabetes, and endocrine disease. It ... Treatment is provided for many endocrine conditions like thyroid disease, ... Prevalence of Diabetes Eye Disease and Its Correlation with Renal Function in a Chain of Community Clinics in India. 619-P " ...
A number of diseases can cause bone pain, including the following: Endocrine, such as hyperparathyroidism, osteoporosis, kidney ... that innervate bone tissue leads to the sensation of bone pain. Bone pain originates from both the periosteum and the bone ... Inflammatory bowel disease. Juvenile idiopathic arthritis. Legg-Calvé-Perthes disease. Lyme disease, which is transmitted by ... and other bone diseases. Thus there are several types of bone pain, each with many potential sources or ...
Langerhans cell histiocytosis
Bone: The most-frequently seen symptom in both unifocal and multifocal disease is painful bone swelling. The skull is most ... Endocrine deficiency often require lifelong supplement e.g. desmopressin for diabetes insipidus which can be applied as nasal ... The disease has gone by several names, including Hand-Schüller-Christian disease, Abt-Letterer-Siwe disease, Hashimoto-Pritzker ... Initially routine blood tests e.g. full blood count, liver function test, U&Es, bone profile are done to determine disease ...
... a major risk-factor for veno-occlusive disease in the liver after allogeneic bone marrow transplantation". Blood. 92 (12): 4568 ... Jeffrey K. Aronson (21 February 2009). Meyler's Side Effects of Endocrine and Metabolic Drugs. Elsevier. pp. 217, 253, 275. ... High-dose (10 mg/day) norethisterone has been associated with hepatic veno-occlusive disease, and because of this adverse ... Reviews in Endocrine and Metabolic Disorders. 3 (3): 211-224. doi:10.1023/A:1020072325818. ISSN 1389-9155. PMID 12215716.. ...
International Society for Clinical Densitometry
"How A Bone Disease Grew To Fit The Prescription". NPR.org. Retrieved 2021-03-27. Official website. ... American Society for Bone & Mineral Research (ASBMR) American Society of Andrology (ASA) American Society of Endocrine ... Endocrine Society (ES) The Obesity Society (TOS) The Pituitary Society (PS) "Densitometry: Journal of Clinical Densitometry". ... Endocrine Nurses Society (ENS) American Association of Clinical Endocrinologists (AACE) Juvenile Diabetes Research Foundation ( ...
... bone tissue and endocrine glands. Damage to vital organs leads to morbidities, including cardiovascular diseases and heart ... bone tissue and endocrine glands. Iron chelation therapy is used to treat iron overload and common iron chelators used are ... Symptoms may vary depending on the severity of the disease. The use of blood transfusions can ease some of these symptoms by ... It is also effective in reducing cardiac-related diseases due to iron overloading. Major side effects of this drug are to the ...
American Society for Bone and Mineral Research
The Society was a founding member of the National Coalition for Osteoporosis and Related Bone Diseases ("Bone Coalition") in ... This led to the rise of a new field - bone and mineral research. In 1974, while attending the annual meeting of The Endocrine ... and founded the National Bone Health Alliance to serve as a resource and raise public awareness of bone diseases. It has also ... The ASBMR published the first edition of The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, a ...
Physical effects of malformed bones vary according to the specific disease. Many involve joint pain caused by abnormal bone ... Forms of dwarfism associated with the endocrine system may be treated using hormonal therapy. If the cause is prepubescent ... Those with bone growth disorders can sometimes be treated with surgery, or physical therapy. Hormone disorders can also be ... "Dwarfism and Bone Dysplasias". Seattle Children's Hospital, Research & Foundation. Archived from the original on 2007-05-04. ...
Primary pigmented nodular adrenocortical disease
Bone health can deteriorate, leading to an increased fracture risk in people with Cushing's syndrome. PPNAD is unique as it ... the endocrine manifestation that comes from Carney Complex (CNC), can be syndromic or isolated. The main cause of isolated ... Primary pigmented nodular adrenocortical disease (PPNAD) was first coined in 1984 by Carney et al. it often occurs in ... NP-59 scintigraphy may be particularly useful in identifying the bilateral nature of the disease. Gene studies are not ...
Osteitis fibrosa cystica
Long bones, which are longer than they are wide, are also among the first affected. As the disease progresses, any bone may be ... "Chapter 4: Endocrine, nutritional, and metabolic diseases". World Health Organization. WHO. 2006-12-11. Archived from the ... The major symptoms of OFC are bone pain or tenderness, bone fractures, and skeletal deformities such as bowing of the bones. ... and von Recklinghausen's disease of bone (not to be confused with von Recklinghausen's disease, neurofibromatosis type I), is ...
Oral manifestations of systemic disease
Another endocrine disorder that may present orally is Addison's Disease. Signs include skin hyperpigmentation, alabaster- ... Osteoporosis is a very common disease associated with a decreased bone mineral density, it mainly affects post menopausal women ... Crohn's Disease is a patchy disease which can affect any area of the GI tract from the oral cavity to the anus. The ... Osteopgenesis imperfecta, also known as brittle bone disease, is caused by a gene mutation affecting the collagen genes, ...
Chronic kidney disease-mineral and bone disorder
The mineral and endocrine functions disrupted in CKD are critically important in the regulation of both initial bone formation ... Chronic Kidney Disease-Mineral and Bone Disorder (NIDDKD) Current Concepts and Management Strategies in Chronic Kidney Disease- ... during growth (bone modeling) and bone structure and function during adulthood (bone remodeling). As a result, bone ... and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder: Synopsis of the Kidney Disease: Improving Global Outcomes ...
Periodontal diagnosis and classification
Endocrine, nutritional and metabolic diseases g. Traumatic lesions h. Gingival pigmentation In the second part of the new ... Radiographs such as bitewings, intra-oral periapicals or panoramics can be done to help assess the bone loss and aid in ... Classification of Periodontal Diseases 2017 In 2017, a new classification system for Periodontal diseases was released. It has ... To finish off the diagnosis, the extent of the disease must be assessed. This is deemed mild (1-2mm), moderate (3-4mm) or ...
"Radiologic Parameters of Orbital Bone Remodeling in Thyroid Eye DiseaseOrbital Bone Remodeling in Thyroid Eye Disease". ... Disease after Total or Subtotal Thyroidectomy". Endocrine Journal. 50 (5): 595-601. doi:10.1507/endocrj.50.595. PMID 14614216. ... Cigarette smoking, which is associated with many autoimmune diseases, raises the incidence 7.7-fold. Mild disease will often ... In mild disease, patients present with eyelid retraction. In fact, upper eyelid retraction is the most common ocular sign of ...
2003). "Clinical and Endocrine Responses to Pituitary Radiotherapy in Pediatric Cushing's Disease: An Effective Second-Line ... The disease is often diagnosed 3-6 years after the onset of illness. Several studies have shown that Cushing's disease is ... Cases of Cushing's disease are rare, and little epidemiological data is available on the disease. An 18-year study conducted on ... Cushing disease, tertiary or secondary hypercortisolism, tertiary or secondary hypercorticism, Itsenko-Cushing disease. ...
This article is about a skin disease common during adolescence. For other acneiform skin diseases, see Acne (disambiguation). ... Nguyen HL, Tollefson MM (August 2017). "Endocrine disorders and hormonal therapy for adolescent acne". Current Opinion in ... and decreased bone mineral density, make its use for male acne impractical in most cases. Pregnant and lactating ... Disease Primers. 1: 15033. doi:10.1038/nrdp.2015.33. PMID 27227877.. *^ a b "Frequently Asked Questions: Acne" (PDF). U.S. ...
... and endocrine-like processes)) may not naturally subside in diseases marked by chronic inflammation (including cancer). The SP ... "Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow ... SP concentrations cannot yet be used to diagnose disease clinically or gauge disease severity. It is not yet known whether ... Microbial Toxins and Diarrhoeal Disease. Ciba Found. Symp. 112. pp. 139-54. doi:10.1002/9780470720936.ch8. PMID 2861068.. ...
Mandel SJ, Brent GA, Larsen PR (September 1993). "Levothyroxine therapy in patients with thyroid disease". Annals of Internal ... Sherwood, Lauralee (2010). "19 The Peripheral Endocrine Glands". Human Physiology. Brooks/Cole. p. 694. ISBN 978-0-495-39184-5. ... suppression of TSH values below normal values will frequently cause cardiac side-effects and contribute to decreases in bone ... For older people (over 50 years old) and people with known or suspected ischemic heart disease, levothyroxine therapy should ...
Diseases of the endocrine system (E00-E35, 240-259). Pancreas/. glucose. metabolism. ... Normally, the bone age is the same as the biological age but for some people, it is older. For many people with advanced bone ... When the cause is unknown, it is called idiopathic short stature. Short stature can also be caused by the bone plates fusing ... However, in some cases, people who are naturally shorter combined with their advanced bone age, end up being even shorter than ...
... removal of one-quarter inch of the center of the hyoid bone, closure of the cut ends of the hyoid bone, and placement of a ... Congenital endocrine disorders (Q89.1-Q89.2, 759.1-759.2). Pituitary. *Congenital hypopituitarism. Thyroid. *Thyroid disease ... between the isthmus of the thyroid and the hyoid bone or just above the hyoid bone. A thyroglossal cyst can develop anywhere ... The Sistrunk procedure is the surgical resection of the central portion of the hyoid bone along with a wide core of tissue from ...
... such as Von Hippel-Lindau disease, multiple endocrine neoplasia, and neurofibromatosis type 2 carry a high risk for the ... The skull bone structure can also be subject to a neoplasm that by its very nature reduces the volume of the intracranial ... Hourigan CS (2006). "The molecular basis of coeliac disease". Clin Exp Med (Review). 6 (2): 53-59. doi:10.1007/s10238-006-0095- ... Frappaz D, Mornex F, Saint-Pierre G, Ranchere-Vince D, Jouvet A, Chassagne-Clement C, Thiesse P, Mere P, Deruty R (1999). "Bone ...
Paterson, Sue (December 17, 2007). Skin Diseases of Exotic Pets. Blackwell Science, Ltd. pp. 74-79. ISBN 9780470752432. .. ... P.J. Bentley (14 March 2013). Endocrines and Osmoregulation: A Comparative Account in Vertebrates. Springer Science & Business ... The new section will however contain cartilage rather than bone, and will never grow to the same length as the original tail. ... Hellebuyck, Tom; Pasmans, Frank; Haesbrouck, Freddy; Martel, An (July 2012). "Dermatological Diseases in Lizards". The ...
The Hanford Thyroid Disease Study, an epidemiologic study of the relationship between estimated exposure doses to radioiodine ... As studies of biological samples (including bone, thyroid glands and other tissues) have been undertaken, it has become ... raising the possibility that endocrine disrupting chemicals like PCBs and dioxins might combine to increase the risks ... Several severe adverse health effects, such as an increased incidence of cancers, thyroid diseases, CNS neoplasms, and possibly ...
배아줄기세포 - 위키백과, 우리 모두의 백과사전
"Stem-cell-based strategies for the treatment of Parkinson's disease". 》Neuro-Degenerative Diseases》 4 (4): 339-347. ISSN 1660- ... "Application of stem cells in bone repair". 》Skeletal Radiology》 37 (7): 601-608. ISSN 0364-2348. PMID 18193216. doi:10.1007/ ... "Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells". 》Nature Biotechnology》 24 (11): ... "Designer's microglia with novel delivery system in neurodegenerative diseases". 》Medical Hypotheses》 83 (4): 510-512. ISSN ...
"MANAGEMENT OF ENDOCRINE DISEASE: Reversible hypogonadotropic hypogonadism". European Journal of Endocrinology. 174 (6): R267-74 ... Bone density scans are recommended to monitor the bone mineral density. ... Laitinen EM, Hero M, Vaaralahti K, Tommiska J, Raivio T (August 2012). "Bone mineral density, body composition and bone ... "Treatment of isolated hypogonadotropic hypogonadism effect on bone mineral density and bone turnover". The Journal of Clinical ...
"Overview of samarium sm 153 lexidronam in the treatment of painful metastatic bone disease". Rev Urol. 6 Suppl 10 (Suppl 10): ... Radiation therapy is used to treat early stage Dupuytren's disease and Ledderhose disease. When Dupuytren's disease is at the ... valvular heart disease, coronary artery disease, heart arrhythmia and peripheral artery disease. Radiation-induced fibrosis, ... Cardiovascular disease. Radiation can increase the risk of heart disease and death as observed in previous breast cancer RT ...
Joint WHO/FAO expert consultation (2003). Diet, Nutrition and the Prevention of Chronic Diseases (PDF). who.int. Geneva: World ... bone health and cancer risk. One low quality meta-analysis reported that adverse effects could include "constipation, ... The Endocrine Society stated that "when calorie intake is held constant [...] body-fat accumulation does not appear to be ... "Nutrition, Metabolism, and Cardiovascular Diseases. 24 (4): 337-43. doi:10.1016/j.numecd.2013.12.008. PMC 4351995. PMID ...
Bugspytkirtelkræft, den frie encyklopædi
"Islet Cell Tumors of the Pancreas / Endocrine Neoplasms of the Pancreas". The Sol Goldman Pancreas Cancer Research Center. ... Zhan HX, Xu JW, Wu D, Zhang TP, Hu SY (2015). "Pancreatic cancer stem cells: New insight into a stubborn disease". Cancer Lett ... See page 95 for citation regarding "... lesser degree of involvement of bones and brain and other anatomical sites." ... Harris, RE (2013). "Epidemiology of pancreatic cancer". Epidemiology of Chronic Disease. Jones & Bartlett. s. 181-190. ISBN 978 ...
Human digestive system
Mouth diseases include tongue diseases and salivary gland diseases. A common gum disease in the mouth is gingivitis which is ... It is both an endocrine gland and an exocrine gland. The endocrine part secretes insulin when the blood sugar becomes high ... They are made of a bone-like material called dentin, which is covered by the hardest tissue in the body-enamel. Teeth have ... It can also arise as a result of other gastrointestinal diseases such as coeliac disease. Coeliac disease is an autoimmune ...
For endocrine problemsEdit. androgens, antiandrogens, estrogens, gonadotropin, corticosteroids, human growth hormone, insulin, ... HRT is not a life-saving drug, nor does it cure any disease. HRT has been prescribed to improve one's quality of life. Doctors ... NSAIDs, anticholinergics, haemostatic drugs, antifibrinolytics, Hormone Replacement Therapy (HRT), bone regulators, beta- ... It describes plant-based drugs to counter diseases. The earliest foundations of ayurveda were built on a synthesis of ...
Vitamin D toxicity
Cardiovascular disease. Evidence suggests that dietary vitamin D may be carried by lipoprotein particles into cells of ... Cosman F, Nieves J, Dempster D, Lindsay R (December 2007). "Vitamin D economy in blacks". Journal of Bone and Mineral Research ... "Evidence for alteration of the vitamin D-endocrine system in blacks". The Journal of Clinical Investigation. 76 (2): 470-3. ... Vieth R (December 2007). "Vitamin D toxicity, policy, and science". Journal of Bone and Mineral Research. 22 Suppl 2: V64-8. ...
Vitamin D deficiency
Deficiency impairs bone mineralization, leading to bone softening diseases such as rickets in children. It can also worsen ... Alpert PT, Shaikh U (October 2007). "The effects of vitamin D deficiency and insufficiency on the endocrine and paracrine ... causing overt bone disease from before birth and impairment of bone quality after birth. ... "Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease". The ...
2015). Epidemiology and Prevention of Vaccine-Preventable Diseases. U.S. Dept. of Health & Human Services, Centers for Disease ... "Joint, Bone, Spine : Revue du Rhumatisme. 81 (2): 118-24. doi:10.1016/j.jbspin.2014.01.001. PMID 24556284.. ... Conjunctivitis is the most common eye disease. Rates of disease is related to the underlying cause which varies by the age ... "Centers for Disease Control and Prevention. Retrieved 2018-12-07.. *^ "Allergic Conjunctivitis". familydoctor.org. Archived ...
Endocrine surgery Traumatic reconstruction Balance Skull base surgery Anterior skull base Swallowing disorders Airway Sleep ... Patients seek treatment from an otorhinolaryngologist for diseases of the ear, nose, throat, base of the skull, and for the ... Temporal bone Allergy Phono-surgery Cleft lip and palate Sleep apnea surgery ...
"Multiple melanocortin receptors are expressed in bone cells". Bone. 36 (5): 820-31. doi:10.1016/j.bone.2005.01.020. PMID ... Addison's disease) when adrenal gland production of cortisol is chronically deficient. In Cushing's disease a pituitary tumor ... Isales CM, Zaidi M, Blair HC (March 2010). "ACTH is a novel regulator of bone mass". Annals of the New York Academy of Sciences ... Addison's disease, the primary adrenal insufficiency (another form of hypocorticism). *Cushing's syndrome, hypercorticism, one ...
Examples include Gaucher disease, Fabry disease, Mucopolysaccharidoses and Glycogen storage disease type II. Such treatments ... endocrine, cardiovascular, pulmonary, ophthalmologic, renal, psychiatric, and dermatologic conditions. ... Bone marrow transplantation. *Gene therapy. Career paths and training. The examples and perspective in this article deal ... Allelic architecture of disease. Main article: Population groups in biomedicine. Sometimes the link between a disease and ...
Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. 13. Springer. pp. 81-137. doi: ... The effector organs of the first homeostatic mechanism are the bones, the kidney, and, via a hormone released into the blood by ... Two other regulatory endocrine axes are the hypothalamic-pituitary-adrenal axis (HPA axis) and the hypothalamic-pituitary- ... Many diseases are the result of a homeostatic failure. Almost any homeostatic component can malfunction either as a result of ...
ಮೆದುಳಿನ ಕ್ಯಾನ್ಸರ್ ಗೆಡ್ದೆ(ಊತ) - ವಿಕಿಪೀಡಿಯ
ಕೆಲವು ಮೆನಿಂಗಿಯೊಮಾಸ್ ಪ್ರಕರಣಗಳಲ್ಲಿರುವ ಬುರುಡೆಯಲ್ಲಿ ಅಪರೂಪವಾಗಿರುವ ಗೆಡ್ದೆಗಳನ್ನು ಶಸ್ತ್ರಚಿಕಿತ್ಸೆ ಮೂಲಕ ಯಶಸ್ವಿಯಾಗಿ ತೆಗೆಯಬಹುದು. ಬಹಳಷ್ಟು ಕಠಿಣ ಪ್ರಕರಣಗಳಲ್ಲಿ ಸ್ಟಿರಿಯಿಟ್ಯಾಕ್ಟಿಕ್ ರೇಡಿಯೊ ಶಸ್ತ್ರಚಿಕಿತ್ಸೆ,ಅಂದರೆ ಗಾಮಾ ಚೂರಿ ಬಳಕೆ,ಸೈಬರ್ ನೈಫ್ ಅಥವಾ ನೊವಿಲಿಸ್ Tx ರೇಡಿಯೊ ಶಸ್ತ್ರಚಿಕಿತ್ಸೆಯು ಅತ್ಯಂತ ಉಪಯುಕ್ತ ಆಯ್ಕೆಯಾಗಿದೆ. ಬಹಳಷ್ಟು ಪಿಟ್ಯುಟರಿ ಅಡೆನೊಮಾಗಳನ್ನು ಶಸ್ತ್ರಚಿಕಿತ್ಸೆ ಮೂಲಕ ತೆಗೆಯಲಾಗುತ್ತದೆ.ಅಂದರೆ ...
... reduction in bone breakdown and neuroprotection. GLP-2 may act in an endocrine fashion to link intestinal growth and metabolism ... GLP-2 and related analogs may be treatments for short bowel syndrome, Crohn's disease, osteoporosis and as adjuvant therapy ... GLP-2 is produced by the intestinal endocrine L cell and by various neurons in the central nervous system. Intestinal GLP-2 is ...
Patients with APECED develop an autoimmune disease that affects multiple endocrine tissues. A GVHD-like disease called thymoma- ... In the two lobes, hematopoietic precursors from the bone-marrow, referred to as thymocytes, mature into T cells. Once mature, T ... However, this disease highlights the importance of the thymus in prevention of autoimmunity. This disease is caused by ... The end result is a disease virtually indistinguishable from GVHD. Myasthenia gravis is an autoimmune disease caused by ...
Desiccated thyroid extract
... whether due to disease or overtreatment, was associated with poorer bone density in women, and with higher rates of atrial ... "Endocrine Today Blog". Endocrinetoday.com. Retrieved 2014-07-24.. *^ "Endocrine Today Blog". Endocrinetoday.com. Retrieved 2014 ... Endocrine Practice. 8 (6): 457-69. PMID 15260011.. *^ Clyde, PW; Harari, AE; Getka, EJ; Shakir, KM (10 December 2003). " ... "Endocrine Today Blog". Endocrinetoday.com. Retrieved 2014-07-24.. *^ Repas, Thomas. Desiccated thyroid in the management of ...
"J. Bone Miner. Res. 22 Suppl 2: V86-90. doi:10.1359/jbmr.07s204. PMID 18290729. S2CID 5476362.. ... Jay R. Harris; Marc E. Lippman; C. Kent Osborne; Monica Morrow (28 March 2012). Diseases of the Breast. Lippincott Williams & ... "Androgen receptor genotypes predict response to endocrine treatment in breast cancer patients". Br. J. Cancer. 105 (11): 1676- ... Ismail Jatoi; Manfred Kaufmann (11 February 2010). Management of Breast Diseases. Springer Science & Business Media. pp. 12, 27 ...
Immune disease. (L03-L04). *Immunomodulators *Immunostimulants. *Immunosuppressants. Muscles, bones,. and joints (M). *Anabolic ... Endocrine. system (H). *Hypothalamic-pituitary hormones. *Corticosteroids *Glucocorticoids. *Mineralocorticoids. *Sex hormones ... Muscular and rheumatic diseases.. As per diclofenac. Salol. No data.. As per diclofenac.. PO, topical.. No data.. Lower urinary ... Medical cannabis, or medical marijuana, refers to cannabis or its cannabinoids used to treat disease or improve symptoms.[ ...
Endocrine Fellows Series: Osteoporosis and Metabolic Bone Diseases - Application Form | the Endocrine Society Center for...
August 5-6, 2015Hotel Santa FeSanta Fe, NMTo apply for the 13th Annual Osteoporosis Fellows Conference, complete all of the fields below. In addition, you must email a letter of recommendation from your program director.
German Institute of Human Nutrition Potsdam-Rehbrücke: Dissertations and Habilitations
Adipose tissue as an endocrine organ - The role of omentin-1 in cardiovascular diseases and bone health. Charité ... The Role of Bone-residing Adipocyte Progenitors in Age-related Stem Cell Dysfunction and Regenerative Processes. Universität ... Habitual meal patterns in an EPIC-Potsdam sub-study - Description, associations with cardiometabolic disease risk factors and ... Contribution of bacterially synthesized folate itamers to folate status and impact on Crohns Disease. Universität Potsdam, ...
Faslodex receives US FDA approval for the treatment of advanced breast cancer in combination with abemaciclib
55.8% had visceral disease and 26.9% had bone-only disease. Twenty-five percent of patients had primary endocrine resistance, ... whose disease progressed on or after neoadjuvant or adjuvant endocrine therapy, ≤12 months from the end of adjuvant endocrine ... in women with disease progression after endocrine therapy.. Dave Fredrickson, Executive Vice President, Head of the Oncology ... or while receiving first-line endocrine therapy for metastatic disease. The study included 669 women randomly assigned to ...
Loss of Appetite in Cats | PetMD
For example, most diseases, including infectious, autoimmune, respiratory, gastrointestinal, bone, endocrine and neurological ... diseases, will cause an animal to avoid eating. Pain and internal obstructions, amongst other factors, can cause the affected ...
Meaghan M. Stumpf, MD | Endocrinology | UVA
... metabolic bone disease, osteoporosis, obesity, and other endocrine disorders. Special interests include support for transplant ... Use of technology to improve outcomes in treatment of endocrine diseases associated with transplantation ... patients who have endocrine disorders, as well as care of young adult patients with endocrine disorders who are transitioning ...
Meniscal tears | Archives of Disease in Childhood
Electronic Code of Federal Regulations (eCFR)
... bone disease such as Pagets disease, and endocrine disorders such as hyperparathyroidism and hyperthyroidism. ... Calcium measurements are used in the diagnosis and treatment of parathyroid disease, a variety of bone diseases, chronic renal ... a disease characterized by the formation of nodules in the lungs, bones, and skin, and Gauchers disease, a hereditary disorder ... Measurements of creatine are used in the diagnosis and treatment of muscle diseases and endocrine disorders including ...
Headache (including migraine) | Archives of Disease in Childhood
Calcium and bone (85). *. Diabetes (360). *. Drugs: endocrine system (130). *. Lipid disorders (23) ... Archives of Disease in Childhood Apr 2010, 95 (Suppl 1) A26-A27; DOI: 10.1136/adc.2010.186338.58 ... Archives of Disease in Childhood Apr 2010, 95 (Suppl 1) A11-A12; DOI: 10.1136/adc.2010.186338.26 ... Archives of Disease in Childhood Apr 2010, 95 (Suppl 1) A95; DOI: 10.1136/adc.2010.186338.208 ...
Magic IS for Everyone
If a person comes down with a major (or minor) disease, or if a bone is broken, going to a doctor is very advantageous. Even so ... But what can you do if your endocrine system begins to fail? How can you repair a disorder of the mind? ... There are ways to help prevent disease and keep a person healthy. Most of these involve working with the scientifically ...
Bone Marrow Failure: Who Treats It? | Children's Minnesota
If your child is facing bone marrow failure, Childrens Minnesota has a team of physicians ready to take care of your child. ... Endocrinologists are doctors with special training and skill in finding and treating diseases of the endocrine system. They ... Who treats bone marrow failure at Childrens Minnesota?. In some cases, children with bone marrow failure syndromes have health ... Cardiologists are doctors with special training and skill in finding, treating and preventing diseases of the heart and blood ...
How To Travel With Lung And Heart Disease | SCUBADOC - Diving Medicine Online
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EndocrinologyAdrenalMetabolismThyroidTumorsResorptionCalciumPaget'sClinicalDisorderTumorSurgeryTreatment of endocrinePediatric endocrineComplicationsHormonesFractureGeneticsDensityOsteomalaciaRicketsEndocrinologistsEndocrinologistHistomorphometryObesityHyperthyroidismFractures2018AbnormalitiesMineralCardiovascular DiseaseMetabolic diseasesInsulinMetastatic Bone DiseaseHormoneCancerDrugsChronicDiagnosis and treatmentGlandsRegulationPagetOutpatient clinicsSymptomsPatientsOsteoporosis and metabolic bone diseasesOsteocalcinSkeletalCoronary arteryAbnormalVitaminMarrowPracticeGeneticClinicInfectious and parasitic diseases
- Based in the Department of Endocrinology, the Metabolic Bone Disease & Endocrine Calcium Center provides superior access to a multidisciplinary team, providing Center-of-Excellence DXA bone density testing and interpretation, on-site laboratory testing, and a fully staffed infusion center for even the most sophisticated testing and drug administration requirements. (clevelandclinic.org)
- In addition we will ask colleagues in other Endocrinology Departments (or other specialties such as Clinical Genetics,Pathology, General Medicine ) to identify potentially suitable patients with endocrine & pituitary tumours from their records. (clinicaltrials.gov)
- By mastering the principles involved in evaluating a child with a potential endocrine condition and developing a sound knowledge base of endocrinology, the pediatric resident will be prepared to perform well as a general pediatrician in the community after graduation. (slideshare.net)
- The branch of medicine that studies the endocrine disorders is known as endocrinology. (tutorialspoint.com)
- Cellular Endocrinology in Health and Disease describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. (bookdepository.com)
- Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. (bookdepository.com)
- Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. (bookdepository.com)
- Endocrinology is a subspecialty of internal medicine that focuses on the diagnosis and care of diseases related to endocrine glands, hormones and metabolism. (castleconnolly.com)
- Endocrinology covers some of the most common conditions and serious public health challenges facing medicine today, and endocrine and metabolic emergencies constitute a large proportion of the clinical workload. (wiley.com)
- When you come to the Cotton O'Neil Diabetes & Endocrinology Center, our endocrine specialists will make sure that you receive the correct diagnosis and a personalized treatment plan. (stormontvail.org)
- Endocrinology is the branch of biology and medicine that focuses on the endocrine system, and although the terms "endocrine" and "endocrinology" didn't come into common usage until the 1800s, the study of endocrinology can be traced back to China over 2,000 years ago, according to American author Robert K. G. Temple in his book, "The Genius of China: 3,000 Years of Science, Discovery, and Invention" (Prion, 1998). (livescience.com)
- At the University of Maryland Center for Diabetes and Endocrinology, we offer education, improved patient safety and specialized expertise to help patients with diabetes and endocrine disorders live happy, healthy and active lives. (umms.org)
- This study will evaluate the clinical response and safety of cone beam computed-tomography guided percutaneous cryoablation in bone metastases from thyroid, adrenal and neuroendocrine tumors in 30 patients. (clinicaltrials.gov)
- Thyroid neoplasms, as well as adrenal and neuroendocrine tumors have the potential to metastasize to bone. (clinicaltrials.gov)
- About 3% of patients with well-differentiated thyroid carcinomas develop secondary bone lesions, while adrenal and neuroendocrine tumors have 10% and 13% bone metastases rates, respectively. (clinicaltrials.gov)
- 10 percent of adults), thyroid disorders (~8 percent of adults), and less common problems such as hypothalamic/pituitary disorders, adrenal disorders, and pancreatic endocrine disorders. (castleconnolly.com)
- We may prescribe hormone supplements for diseases such as hypothyroidism or adrenal insufficiency. (stormontvail.org)
- The eight hormone-secreting glands of the endocrine system are the adrenal gland, hypothalamus, pancreas, parathyroid gland, pineal gland, pituitary gland, reproductive glands (ovaries and testes) and thyroid gland. (livescience.com)
- Our many fellowship-trained surgeons offer multiple options for your adrenal and endocrine health. (providence.org)
- When tumors are present in the adrenal gland, they negatively affect the way the body produces these hormones and often result in diseases that lead to hypertension, weakening of the muscles, weight gain, buffalo humps and bruising. (providence.org)
- Adrenal surgery is used to treat those diseases by removing benign and malignant tumors within the adrenal gland. (providence.org)
- A distinct finding associated with Wolman disease is the hardening of adrenal gland tissue due to the accumulation of calcium (calcification). (rarediseases.org)
- Metabolic bone disease describes a diverse group of disorders of bone metabolism, most commonly caused by abnormalities of minerals (such as calcium or phosphorous) or vitamin D. (nature.com)
- Her clinical research interests are in the areas of bone metabolism and obesity. (massgeneral.org)
- My research focuses on the dual fields of bone disease and obesity metabolism. (massgeneral.org)
- Gagel has focused on the clinical management of osteoporosis and other disorders of bone metabolism. (mdanderson.org)
- The authoritative reference to bone diseases and disorders of mineral metabolism, revised and update. (wiley-vch.de)
- Now in its ninth edition, The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone and mineral health. (wiley-vch.de)
- The ninth edition provides concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. (wiley-vch.de)
- The new edition of this invaluable reference expands coverage and includes the most recent developments in the field that help to strengthen its usefulness and ensure that the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism maintains its place as the pre-eminent reference on bone and mineral health. (wiley-vch.de)
- Written for advanced students, clinicians, and researchers working in the field of bone health and disease, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease. (wiley-vch.de)
- The endocrine system works inside you to regulate your metabolism, proper growth and development of muscles and tissues, as well as tissue function, sexual function, reproduction, sleep and mood, among other things. (juicing-for-health.com)
- Vitamin D deficiency results in abnormalities in calcium, phosphorous, and bone metabolism. (aace.com)
- Metabolic disorders include numerous diseases, often inherited, in which chemical processes necessary for metabolism are not functioning properly. (castleconnolly.com)
- Impaired glucose metabolism is common and contributes to the risk of diabetes and cardiovascular disease. (medscape.com)
- New therapeutic approaches to diabetes and heart disease may be anticipated if this bone-derived protein is involved in the regulation of glucose metabolism and cardiovascular risk. (medscape.com)
- In addition, recent data suggest the influence of bone metabolism on energy balance which may be relevant for cardiovascular disease. (elsevier.es)
- These developments were paralleled by significant progress in our understanding of the local regulation of bone metabolism. (endocrine-abstracts.org)
- She has been or is on the editorial boards of major scientific journals and is currently Editor-in-Chief of Clinical Cases in Bone and Mineral Metabolism. (iofbonehealth.org)
- The term 'metabolic bone disease' encompasses an unrelated group of systemic conditions that impact on skeletal collagen and mineral metabolism. (scielo.org.za)
- Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. (thefreedictionary.com)
- This clinic specializes in seeing children ages birth to 18 with diabetes and classical endocrine problems, including short stature, delayed or precocious puberty, thyroid disorders, disorders of bone metabolism. (umms.org)
- We investigated the metabolic phenotype associated with impaired bone metabolism in mice lacking the gene that encodes NPP1 ( Enpp1 −/− mice). (biologists.org)
- The progressive systemic disease, the post-operative complications, and the pre-operative neurologic impairment were associated to a worst global survival rate in the thyroid cancer. (clinicaltrials.gov)
- Graves-Basedow disease is a medical disorder that may manifest several different conditions including hyperthyroidism (over activity of thyroid hormone production), infiltrative exophthalmos (protruberance of one or both eyes and associated problems) and infiltrative dermopathy (a skin condition usually of the lower extremities). (dailystrength.org)
- I remember her telling me during my last visit that too much thyroid hormone can cause osteoperosis, and a eating away of the bones. (dailystrength.org)
- The condition can also arise as a result of other endocrine disorders, such as hyperthyroidism (overactive thyroid). (livescience.com)
- An important clue to the presence of thyroid disease in an elderly patient is a history of thyroid disease in another close family member such as a brother, sister or child of the patient. (thyroid.org)
- During therapy, the effects of change in thyroid function on other body systems must be closely monitored, due to an increased likelihood of co-existing cardiac, central nervous system and thyroid disease in older patients. (thyroid.org)
- The most common cause of hyperthyroidism in the US is overproduction of thyroid hormone due to Graves' disease , toxic multinodular goiter or a toxic adenoma. (providence.org)
- and features detailed coverage of disorders by system, as well as, metabolic bone diseases, neuroendocrine tumors, and more. (wiley.com)
- Pituitary tumors are often harmless, but some can cause diseases, such as hyperthyroidism. (stormontvail.org)
- Since 1990 she has been Director, Regional Center on Hereditary Endocrine Tumors, University Hospital of Florence. (iofbonehealth.org)
- Also, two somatic heterozygous NONO mutations were found in endocrine-related tumors, p.H146R (parathyroid) and p.R293H (small intestine neuroendocrine tumor). (bireme.br)
- P aget's disease of bone is a chronic disorder, characterised by focal areas of excessive osteoclastic bone resorption accompanied by a secondary increase in osteoblastic bone formation. (mja.com.au)
- b) after the administration of parathyroid hormone has been terminated, the administration of a bone resorption inhibitor during a period of approximately 12 to 36 months. (google.com)
- 4. A pharmaceutical preparation according to claim 1 adapted for said administration of bone resorption inhibitor for approximately 12 to 36 months. (google.com)
- 5. A pharmaceutical preparation according to claim 4 , adapted for said administration of bone resorption inhibitor for approximately 12 to 18 months. (google.com)
- 7. A preparation according to claim 1 wherein the said bone resorption inhibitor is a bisphosphonate. (google.com)
- 9. A preparation according to claim 1 wherein the said bone resorption inhibitor is a substance with estrogen-like effect. (google.com)
- Over the past three decades, Gagel has made significant contributions to bone research, including studies on calcitonon, a major regulator of bone resorption. (mdanderson.org)
- Paget's disease of bone (PDB) is a noninflammatory, metabolic, skeletal disorder characterized by localized excessive osteoclastic bone resorption that is followed by compensatory increased osteoblastic activity leading to unstructured, fibroblastic, and biomechanically unstable bone. (springer.com)
- This led to the discovery or development of specific inhibitors of some of these key enzymes, including Src, as proof-of-concept lead compounds or potential clinical candidates for the prevention of diseases associated with increased bone resorption, such as osteoporosis and metastatic bone disease. (aacrjournals.org)
- In this article, we review our current understanding of the signaling pathways that regulate osteoclast formation, activation, and survival with specific reference to the role of Src tyrosine kinase and downstream signaling and highlight in a variety of models of increased bone resorption the effects of Src kinase inhibitors that have been targeted to bone to limit potential adverse effects on other cells. (aacrjournals.org)
- Chronic localized bone remodeling disorder characterized by increased bone resorption, bone formation, and remodeling, which may lead to major long bone and skull deformities. (bmj.com)
- Despite reduction of bone resorption, OPG did not inhibit AIA-induced bone loss. (springer.com)
- a product of the resorption of bone. (thefreedictionary.com)
- The Metabolic Bone Disease & Endocrine Calcium Center is comprised of a team of expert physician-scientists who specialize in the treatment of a vast number of common and rare bone, calcium and other mineral disorders associated with the regulation of skeletal and parathyroid hormone functions. (clevelandclinic.org)
- The Metabolic Bone Disease & Endocrine Calcium Center team has partnered with their highly skilled Endocrine Surgery colleagues to provide timely, integrated assessment of parathyroid abnormalities with ultrasonography, direct laryngoscopy, and other state of the art testing. (clevelandclinic.org)
- The Metabolic Bone Disease & Endocrine Calcium Center and the Department of Endocrine Surgery continue to collaborate to provide comprehensive pre-surgical assessment, timely surgical intervention, and post-surgical follow up for all patients with parathyroid disease in their care. (clevelandclinic.org)
- The Metabolic Bone Disease & Endocrine Calcium Center addresses problems associated with the regulation of the body's bone, mineral and hormone functions. (clevelandclinic.org)
- Hypothesis: Among adults with SCI for a long time, treatment with a drug named Rosuvastatin or a sugar pill, with supplements (coenzyme Q10, calcium and vitamin D), for twelve months can decrease their endocrine metabolic disease risk by increasing bone density and reducing inflammation. (clinicaltrials.gov)
- Hypothesis: Twelve months of statin therapy with concurrent coenzyme Q10 (CoQ10), to reduce risk of statin neuromyotoxicity, and standard care (calcium 1250mg OD and vitamin D3 2000IU OD) will be superior to placebo with CoQ10 and standard care, for augmenting knee region BMD and reducing inflammatory stress (hs-CRP), thereby reducing endocrine metabolic disease risk. (clinicaltrials.gov)
- Faculty members present clinical content that incorporate practice guidelines, newly reported research findings, preclinical research and clinical practice patterns from across the field of bone and calcium disorders. (endocrine.org)
- It can be given as a medication for the treatment of low blood calcium and hyperparathyroidism due to kidney disease, low blood calcium due to hypoparathyroidism, osteoporosis, osteomalacia, and familial hypophosphatemia, and can be taken by mouth or by injection into a vein. (wikipedia.org)
- Stimulating release of calcium from bone. (wikipedia.org)
- The resulting decrease in serum phosphate causes hydroxyapatite (Ca5(PO4)3OH) to dissolve out of bone, thus increasing serum calcium. (wikipedia.org)
- D is the vitamin that allows calcium to be absorbed into the bones. (dailystrength.org)
- Coverage includes the presentation, diagnosis, management, and treatment of endocrine and metabolic disorders in an acute care setting, as well as the most up-to-date guidance on issues including clinical lipidology, glucose, sodium, calcium and phosphate, and more. (wiley.com)
- Parathyroid hormone and vitamin D interactions work to release calcium from the bones, gut, and kidneys for deposit into the bloodstream. (petmd.com)
- A calcium-binding substance produced by osteoblasts that is essential to bone mineralization and can be used as a biomarker for osteoporosis. (thefreedictionary.com)
- A gene on chromosome 1q25-q31 that encodes a protein which constitutes 1-2% of bone protein, which binds strongly to apatite and calcium. (thefreedictionary.com)
- n vitamin Kdependent calcium-binding protein synthesized by osteoblasts and found primarily in bone. (thefreedictionary.com)
- Identify and manage some of the nosological entities that endocrinologists are called upon for diagnosis and treatment (i.e., normocalcemic hyperparathyroidism, Paget's disease, adult forms of osteogenesis imperfecta, fibrous dysplasia of bone, etc. (endocrine.org)
- Paget's disease of bone is common, affecting up to 4% of Australians over the age of 55 years. (mja.com.au)
- The cause of Paget's disease is unknown, but there is a strong genetic influence. (mja.com.au)
- Recently, mutations in the sequestosome 1/p62 gene have been identified as a cause of familial Paget's disease and of some apparently sporadic cases of the disease. (mja.com.au)
- Paget's disease is eminently treatable. (mja.com.au)
- Paget's disease predominantly affects the elderly. (mja.com.au)
- 5 Recent studies from the United Kingdom and New Zealand suggest that the incidence of Paget's disease is falling, perhaps by as much as 50% over the past 20 years, and that the severity of newly diagnosed cases is falling. (mja.com.au)
- The cause of Paget's disease is unknown. (mja.com.au)
- 8 , 9 Genome linkage scans have identified several loci associated with familial Paget's disease. (mja.com.au)
- 13 , 14 Mutations in the SQSTM1/p62 gene are therefore a plausible cause of Paget's disease, but it is unclear how germline DNA mutations (present in every osteoclast) cause bone disease that is focal in nature. (mja.com.au)
- 15 Presumably, the declining incidence of Paget's disease reflects a decline in one or more as yet unidentified environmental influences. (mja.com.au)
- Paget's disease presents clinically in a variety of ways ( Box 1 ), depending in part on the bones affected. (mja.com.au)
- Paget's disease of bone (commonly known as Paget's disease or historically, osteitis deformans) is a condition involving cellular remodeling and deformity of one or more bones. (wikipedia.org)
- Paget's disease may affect any one or multiple bones of the body (most commonly pelvis, femur, and lumbar vertebrae, and skull), but never the entire skeleton, and does not spread from bone to bone. (wikipedia.org)
- Rarely, a bone affected by Paget's disease can transform into a malignant bone cancer. (wikipedia.org)
- As the disease often affects people differently, treatments of Paget's disease can vary. (wikipedia.org)
- Although there is no cure for Paget's disease, medications (bisphosphonates and calcitonin) can help control the disorder and lessen pain and other symptoms. (wikipedia.org)
- Paget's disease affects from 1.5 to 8.0 percent of the population, and is most common in those of British descent. (wikipedia.org)
- Mild or early cases of Pagets are asymptomatic, and so most people are diagnosed with Paget's disease incidentally during medical evaluation for another problem. (wikipedia.org)
- Approximately 35% of patients with Paget's have symptoms related to the disease when they are first diagnosed. (wikipedia.org)
- Paget's may first be noticed as an increasing deformity of a person's bones. (wikipedia.org)
- Paget's disease affecting the skull may lead to loss of hearing in one or both ears due to compression of the nerves in the inner ear. (wikipedia.org)
- Paget's disease is a frequent component of multisystem proteinopathy. (wikipedia.org)
- Advanced Paget's disease may lead to other medical conditions, including: Osteoarthritis may result from changes in bone shape that alter normal skeletal mechanics. (wikipedia.org)
- Heart failure is a rare, reported consequence of severe Paget's disease (i.e. more than 40% skeletal involvement). (wikipedia.org)
- Kidney stones are somewhat more common in patients with Paget's disease. (wikipedia.org)
- Nervous system problems may occur in Paget's disease, resulting from increased pressure on the brain, spinal cord, or nerves, and reduced blood flow to the brain and spinal cord. (wikipedia.org)
- When Paget's disease affects the facial bones, the teeth may become loose. (wikipedia.org)
- Paget's disease is not associated with osteoporosis. (wikipedia.org)
- Although Paget's disease and osteoporosis can occur in the same patient, they are different disorders. (wikipedia.org)
- Despite their marked differences, several treatments for Paget's disease are also used to treat osteoporosis. (wikipedia.org)
- Paget's disease may be caused by a slow virus infection (i.e., paramyxoviridae) present for many years before symptoms appear. (wikipedia.org)
- Laboratory contamination may have played a role in past studies linking paramyxovirus (e.g. measles) to Paget's disease. (wikipedia.org)
- There is a hereditary factor in the development of Paget's disease of bone. (wikipedia.org)
- Two genes, SQSTM1 and RANK, and specific regions of chromosome 5 and 6 are associated with Paget's disease of bone. (wikipedia.org)
- Genetic causes may or may not involve a family history of Paget's disease. (wikipedia.org)
- About 40-50% of people with the inherited version of Paget's disease have a mutation in the gene SQSTM1, which encodes a protein, called p62, that is involved in regulating the function of osteoclasts (bone cells). (wikipedia.org)
- Paget's disease of bone is associated with mutations in RANK. (wikipedia.org)
- Paget's disease is the second most common bone remodeling disease after osteoporosis, occurring in 1%-2% of white adults older than 55. (aace.com)
- Paget's disease of bone (PDB) was originally described in a report that has become a classic in the medical literature. (springer.com)
- Paget's disease occurs most commonly in people of British descent. (springer.com)
- For other diseases named after Paget, see Paget's disease (disambiguation) . (wikipedia.org)
- The findings probably correspond to the "cotton wool spots" seen on plain films in the later stages of Paget's disease. (wikipedia.org)
- Michael Baum, emeritus professor of surgery at University College London, suggested that the sitter had Paget's disease of bone. (wikipedia.org)
- Paget's disease affecting the skull may cause frontal bossing, increased hat size, and headaches. (wikipedia.org)
- Clinical Implications: Statins may be safe and effective therapy for adults living with SCI who are at increased risk of endocrine metabolic disease as they age. (clinicaltrials.gov)
- Image-guided percutaneous radiofrequency ablation and cryoablation techniques have been studied in clinical trials and are considered effective options in pain palliation of patients with bone metastatic disease. (clinicaltrials.gov)
- Clinical endocrinologists worldwide rely on Endocrine Practice, the official journal of the American Association of Clinical Endocrinologists (AACE), to keep them on the leading edge of treatment of patients with endocrine diseases. (aace.com)
- Elaine W. Yu, MD, MMSc is a clinical researcher and endocrinologist in the Endocrine Unit at the Massachusetts General Hospital (MGH). (massgeneral.org)
- i) Training our fellows, residents and students in the identification and management of endocrine abnormalities developing in patients who have been diagnosed with and treated for neoplasms and/or who have received HSCT at the NIH-Clinical center. (knowcancer.com)
- ii) Developing new clinical studies for the recognition and therapy of endocrine side effects related to cancer therapy and/or HSCT: this protocol will eventually lead to new, separate protocols that will address specific aspects of endocrinopathies in childhood cancer survivors and HSCT survivors. (knowcancer.com)
- With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information accessible for clinical interventions. (wiley-vch.de)
- It is the best journal to keep up to date with endocrine pathophysiology both in the clinical and in the research field. (elsevier.es)
- From 1998 she has been Director of the Clinical Unit on Metabolic Bone Disorders, University Hospital of Florence. (iofbonehealth.org)
- The Endocrine Surgery Fellowship in the Division of General and Gastrointestinal Surgery provides intensive training in the diagnosis and treatment of endocrine diseases, experience in a multidisciplinary approach to treatment planning and opportunities for collaborative clinical and basic science research. (massgeneral.org)
- The second-year fellow will continue to work on the clinical research projects selected during the first year, and will be actively involved in maintaining the endocrine surgery databases and coordinating specific research projects. (massgeneral.org)
- Clinical features and diagnosis of celiac disease. (scielo.org.za)
- Biochemical markers for bone turnover for the clinical assessment of metabolic bone disease. (scielo.org.za)
- Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, disease-modifying properties, and side effects: a randomized, double-blind, placebo-controlled clinical trial. (springer.com)
- PURPOSE: To describe treatment patterns and clinical outcomes among postmenopausal women with metastatic ER+/HER-2- breast cancer treated with ≥ 2 lines of endocrine therapy or chemotherapy in the metastatic setting. (rti.org)
- The individual disease course is difficult to predict due to the heterogeneity of clinical presentation as well as radiological and pathological findings. (eurekaselect.com)
- The IOM guidelines are so different than the Endocrine Society's guidelines that this study will just add to the controversy," said lead study author Dr. Holly Kramer, an associate professor of medicine at Loyola University Medical Center in Maywood, Ill. "We really need clinical trials to settle the whole issue, but what's clear is that these threshold levels make a huge difference in how many people would be taking vitamin D. (bio-medicine.org)
- Paget disease of bone is a disorder that causes bones to grow larger and weaker than normal. (medlineplus.gov)
- Low energy (with or without an eating disorder) in combination with menstrual disorder and altered mineral bone density is known as the female athlete triad . (medscape.com)
- Talk with your family doctor or provider if you suspect your child may have an endocrine disorder. (mainehealth.org)
- When the endocrine system isn't working properly, you may be diagnosed with an endocrine disorder, such as diabetes or hyperthyroidism. (stormontvail.org)
- Nearly one in 10 older adults in the U.S. has the disorder , according to the Centers for Disease Control and Prevention. (livescience.com)
- Though osteoporosis is often thought of as strictly a bone disorder, it often falls under the treatment of endocrinologists because of its underlying causes. (livescience.com)
- Diabetes - a disease in which the pancreas stops producing insulin, the hormone that regulates blood sugar levels - is the most common endocrine disorder in the U.S., affecting about 8 percent of the population, according to the National Institute of Diabetes and Digestive and Kidney Diseases. (livescience.com)
- While some of the symptoms of hyperthyroidism and hypothyroidism are similar to those in younger patients, it is not uncommon for both hyperthyroidism and hypothyroidism to be manifest in subtle ways in older patients, often masquerading as diseases of the bowel or heart or a disorder of the nervous system. (thyroid.org)
- A chronic bone disorder that is characterized by focal areas of increased bone remodeling, resulting in overgrowth of poorly organized bone. (bmj.com)
- History of an endocrine or metabolic disorder (e.g. (hss.edu)
- Thus, with growing knowledge of the pathways regulating osteoclast function and the appreciation that some of these are active also in tumor cells, drug companies have made efforts to identify small-molecular lead compounds for development into new therapeutic agents for the prevention of bone loss with efficacy that matches or supersedes that of bisphosphonates. (aacrjournals.org)
- Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic mice. (springer.com)
- Pituitary and other endocrine tumour samples will be collected at surgery and kept in liquid nitrogen or −80 C. They will be coded with unique ID numbers. (clinicaltrials.gov)
- Within the bone field, my ongoing research projects include (1) studying skeletal health after bariatric (weight loss) surgery in obese patients, (2) determining the physiologic mechanisms involved in bone loss after bariatric surgery, and (3) using these insights to guide management of bone health in bariatric surgery patients. (massgeneral.org)
- The Endocrine Surgery Fellowship Program was established by Massachusetts General Hospital and Brigham and Women's Hospital in accordance with guidelines from the American Association of Endocrine Surgeons (AAES) . (massgeneral.org)
- The fellow will work under the guidance and mentorship of Fellowship Program Directors Sareh Parangi, MD, from Mass General, Dr. Matthew Nehs from Brigham and Women's, along with other Endocrine Surgery faculty members. (massgeneral.org)
- This section describes objectives and curricula for the first and second years of the Endocrine Surgery Fellowship. (massgeneral.org)
- Fairly absolute indications for surgery include moderate or severe eye disease in Graves' disease, large goiter with compressive symptoms, any suspicion of cancer, and pregnant patients or those wanting to become pregnant in the next one to two years. (providence.org)
- There is a dedicated ultrasound machine for diagnostic imaging and fellows will routinely perform fine needle aspiration (FNA) biopsies in the clinic, and a close working relationship with radiology, cytopathology and endocrine surgery is maintained. (umms.org)
Treatment of endocrine1
- We develop care plans using the latest technological advancements in diagnosis and treatment of endocrine disorders. (cookchildrens.org)
- Goal: To acquire and demonstrate the fund of knowledge and practical skills necessary to manage common and complex pediatric endocrine conditions in infants, children, and adolescents. (slideshare.net)
- How are pediatric endocrine disorders treated? (mainehealth.org)
- Treatment varies for each different type of pediatric endocrine issue. (mainehealth.org)
- Pediatric Endocrine Clinic. (umms.org)
- Fellows will work with pediatric endocrine attendings during these clinics. (umms.org)
- Other complications of Paget disease of bone depend on which bones are affected. (medlineplus.gov)
- The disease is often asymptomatic, but can cause bone pain, deformity, fracture and other complications. (mja.com.au)
- 1 The disease results in bone expansion and structural weakness, which can cause pain, deformity, and a range of complications. (mja.com.au)
- In addition to complications seen from exposure to chemotherapy and radiation, patients undergoing allogeneic transplantation can experience unique late effects secondary to graft versus host disease (GVHD) and autoimmunity. (medscape.com)
- The symptoms of Wolman disease often get progressively worse eventually leading to life-threatening complications during infancy including extremely low levels of circulating red blood cells (severe anemia), liver (hepatic) dysfunction or failure, and physical wasting away and severe weakness often associated with chronic disease and marked by weight loss and loss of muscle mass (cachexia or inanition). (rarediseases.org)
- SSEs often occur in women with oestrogen-receptor-positive advanced breast cancer and the associated complications have a substantial disease and economic burden. (springer.com)
- The diseases caused by either the deficiency or excessive of hormones is known as endocrine diseases. (tutorialspoint.com)
- The endocrine system is a group of glands and cells that make hormones, which are released into your blood. (stormontvail.org)
- The body's hormones, and the glands that produce them, make up the endocrine system . (livescience.com)
- Here are 11 interesting facts that may surprise you about the endocrine system, its glands and its hormones. (livescience.com)
- The new term sparked intense research on the endocrine system in the first half of the 20th century, and scientists fervently worked to identify and understand the various hormones in the body. (livescience.com)
- Not all hormones come from the endocrine system. (livescience.com)
- But some other organs and tissues that are not generally considered part of the endocrine system also produce and secrete hormones. (livescience.com)
- Individuals with paralysis after SCI will have large declines in their bone density ant increases in fat mass which increases their risk of fracture and heart disease. (clinicaltrials.gov)
- Rationale: Individuals with motor-complete spinal cord injury (SCI) undergo dramatic changes in body composition in the first 18 months post-injury, including declines in bone mineral density (BMD) that increase lower-extremity fragility fracture risk, and increases in fat mass that increase cardio-metabolic disease (CMD) risk. (clinicaltrials.gov)
- Any increased physiological function, such as a fracture in the bone, will usually mean increased concentration of the tracer. (wikipedia.org)
- These structural changes cause the bone to weaken, which may result in deformity, pain, fracture, or arthritis of associated joints. (wikipedia.org)
- Fracture care: Certain endocrine diseases, such as osteoporosis, can increase your risk of breaking bones. (stormontvail.org)
- Symptomatic patients typically experience pain localized to the bone or joint, either from the pagetic lesion, secondary osteoarthritis, deformity, or pathological fracture. (bmj.com)
- Particularly, studies of human and animal genetics have led to identification of novel, more specific, signaling pathways in bone cells that can provide targets for new therapeutics. (endocrine-abstracts.org)
- Data Collected: Subjects' bone density will be collected at the start and end of the study. (clinicaltrials.gov)
- Change in bone density between the two groups will be compared to see if one is better. (clinicaltrials.gov)
- She is currently the Director of the MGH Bone Density Center and Assistant Professor in Medicine at Harvard Medical School. (massgeneral.org)
- Just found out on Friday that my Doctor has submitted a referral for me to get a bone density scan. (dailystrength.org)
- More than 8 million of the 44 million Americans who have either osteoporosis or low bone mineral density (BMD) are men. (aace.com)
- Low bone density - lower than normal levels of minerals in your bones - cause your bones to become thin, weak and fragile. (stormontvail.org)
- Endocrinologists work with patients who have very abnormal bone density test results. (stormontvail.org)
- Bone mineral density determinations by dual-energy-x-ray absorptiometry in the management of patients with Marfan syndrome - some factors which affect the measurement. (scielo.org.za)
- Radiographic damage associated with low bone mineral density and vertebral deformities in rheumatoid arthritis: the Oslo-Truro-Amsterdam (OSTRA) collaborative study. (springer.com)
- Calcitriol is prescribed for: Treatment of hypocalcaemia - hypoparathyroidism, osteomalacia (adults), rickets (infants, children), renal osteodystrophy, chronic kidney disease Treatment of osteoporosis Prevention of corticosteroid-induced osteoporosis Calcitriol has been used in an ointment for the treatment of psoriasis, although the vitamin D analogue calcipotriol (calcipotriene) is more commonly used. (wikipedia.org)
- Metabolic bone disease including rickets and skeletal dysplasias xii. (slideshare.net)
- Kwashiorkor-Marasmus syndrome and nutritional rickets - a bone biopsy study. (scielo.org.za)
- 17. Raubenheimer EJ, van Heerden WFP, Potgieter D. Static and dynamic bone changes in hospitalized patients suffering from rickets - a histomorphometric study. (scielo.org.za)
- Vitamin D is essential for good bone health, and it's necessary to prevent the disease known as rickets. (bio-medicine.org)
- Endocrinologists are medical doctors (MD) or doctor of osteopathic medicine (DO) who treat people with ailments of the endocrine system. (castleconnolly.com)
- Endocrine and Metabolic Medical Emergencies: A Clinician's Guide provides a singular reference to help endocrinologists, acute and general medicine clinicians, hospitalists and critical care physicians, and general practitioners recognize the symptoms of endocrine emergencies and provide the highest standards of care. (wiley.com)
- At Providence, our endocrinologists, radiologists, and endocrine surgeons work in partnership to provide personalized attention to your endocrine health. (providence.org)
- The Endocrine Society is an international group of endocrinologists. (bio-medicine.org)
- Part I: Metabolic bone disease: histomorphometry as a diagnostic aid. (scielo.org.za)
- Osteopaenia and osteo-malacia after gastrectomy: interrelations between biochemical markers of bone remodeling, vitamin D metabolites and bone histomorphometry. (scielo.org.za)
- This manuscript presents histomorphometry as a quantifiable method for the accurate assessment of metabolic bone disease at cellular level. (scielo.org.za)
- 2. Steinche T. Bone histomorphometry in the pathophysiological evaluation of primary and secondary osteoporosis and various treatment modalities. (scielo.org.za)
- At the end of the treatment, bone structure was analyzed by histomorphometry. (springer.com)
- Serum bone GLA protein compared to bone histomorphometry in endocrine diseases. (thefreedictionary.com)
- Delayed puberty due to chronic disease or anorexia nervosa v. Exogenous obesity vi. (slideshare.net)
- Endocrine and genetic causes of obesity viii. (slideshare.net)
- Inactivity and obesity are closely linked conditions accounting for a large burden of chronic disease and impaired function, indeed the popular press has called inactivity the "new cancer. (nih.gov)
- While Graves' disease is still a common cause of hyperthyroidism, toxic nodular goiter is seen more frequently in the older patient. (thyroid.org)
- Insights into material and structural basis of bone fragility from diseases associated with fractures: how determinants of the biomechanical properties of bone are compromised by disease. (fluoridealert.org)
- Minimal trauma fractures in bone diseases are the result of bone fragility. (fluoridealert.org)
- Osteoporosis is a common disease in aging people, and makes bones less dense and more prone to fractures. (livescience.com)
- This results in hypercalcemia, which can lead to muscle aches, osteoporosis, abdominal pain, kidney stones and bone fractures. (providence.org)
- Many people with classic Paget disease of bone do not experience any symptoms associated with their bone abnormalities. (medlineplus.gov)
- Genetic syndromes and familial inheritance patterns with endocrine abnormalities ix. (slideshare.net)
- and other diseases (idiopathic male osteoporosis, corticosteroid-induced osteoporosis) produce abnormalities in the material composition and structure that lead to bone fragility. (fluoridealert.org)
- Despite the increased bone tissue mass, the bone strength is reduced due to several abnormalities in mineral. (fluoridealert.org)
- Infants with Wolman disease have serious digestive abnormalities including malabsorption, a condition in which the intestines fail to absorb nutrients and calories form food. (rarediseases.org)
- Fluoride is incorporated into the crystalline lattice of hydroxyapatite, making the lattice more stable and less soluble and increasing the crystallinity of the bone mineral. (fluoridealert.org)
- In addition, fluoride alters the interface between mineral and collagen that may influence the mechanical properties of bone (80). (fluoridealert.org)
- He is a charter member of the American Society for Bone and Mineral Research and for the past 30 years has been broadly involved in the development of strategies to prevent and treat osteoporosis. (mdanderson.org)
- However, for individuals with diabetes, cardiovascular disease (CVD) remains the main problem. (diabetesjournals.org)
- Different epidemiological studies show the relationship between osteoporosis, cardiovascular disease, and cardiovascular-related mortality. (elsevier.es)
- The relationship between osteoporosis, cardiovascular disease, and mortality associated to the latter has previously been reported. (elsevier.es)
- His major interest in this role is in the prevention of atherosclerotic cardiovascular disease, such as heart attacks, strokes and peripheral vascular disease. (mountsinai.org)
- Here, we report that p27 Kip1 plays a major role in cardiovascular disease through its effects on the proliferation of bone marrow-derived (BM-derived) immune cells that migrate into vascular lesions. (jci.org)
- She was a Visiting Scientist in Metabolic Diseases, Metabolic Diseases Branch, NIH, Bethesda, Maryland, and additionally earned a Ph.D. in Cell Biology at the University of Rome. (iofbonehealth.org)
- Metabolic diseases affecting bone are generally diagnosed late when patients present clinically with end stage skeletal debilitation. (scielo.org.za)
- Metabolic diseases of bone. (scielo.org.za)
- Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. (bireme.br)
- These magnesium-rich nuts and seeds help stabilize insulin levels and lower cortisol levels which can shock your endocrine system if too high. (juicing-for-health.com)
- Ectonucleotide pyrophosphatase/phosphodiesterase-1 (NPP1) controls bone mineralization through the generation of pyrophosphate, and levels of NPP1 are elevated both in dermal fibroblast cultures and muscle of individuals with insulin resistance. (biologists.org)
- Enpp1 −/− mice had increased levels of the insulin-sensitizing bone-derived hormone osteocalcin but unchanged insulin signalling within osteoblasts. (biologists.org)
- low vitamin D has also been associated with high blood pressure, insulin resistance and the metabolic syndrome -- a group of symptoms that signal higher risk for diabetes and heart disease. (bio-medicine.org)
Metastatic Bone Disease1
- The first gene we wish to study causes familial acromegaly, a disease resulting from a pituitary adenoma secreting growth hormone. (clinicaltrials.gov)
- Plant-based proteins are much better sources of protein, fiber, and the other vitamins and nutrients that help your hormone health and balance your endocrine system. (juicing-for-health.com)
- In particular, postmenopausal women sometimes develop the disease because of their low levels of the hormone estrogen, which helps to maintain bone mass. (livescience.com)
- A rare type of bone cancer called osteosarcoma has been associated with Paget disease of bone. (medlineplus.gov)
- This type of cancer probably occurs in less than 1 in 1,000 people with this disease. (medlineplus.gov)
- In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
- Radiograph and ultrasound imaging can also be used for diagnosing underlying conditions, such as kidney disease, bladder stones, or cancer. (petmd.com)
- Fine needle aspirates (liquids) from the lymph nodes and bone marrow can be used for diagnoses of lymphoma , or cancer of the blood. (petmd.com)
- 4. Guise TA, Mundy GR. Cancer and bone. (scielo.org.za)
- The delayed diagnosis complicates effective therapy, and both forms of chronic pancreatitis (CP) result in severe disability, lifelong metabolic disease, and a high risk of pancreatic cancer. (nih.gov)
- Georgetown Lombardi faculty conducts research and provides care on many diseases and disorders, with a particular focus and expertise on cancer. (georgetown.edu)
- Drugs known as 'statins' used often to reduce high cholesterol, may help to reduce bone loss and inflammation. (clinicaltrials.gov)
- [ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
- Chronic dental problems may lead to infection of the jaw bone. (wikipedia.org)
- The disease is a chronic bone abnormality, which may affect a single, several, or many bones, but never involves the entire skeleton. (springer.com)
- Neurological symptoms due to bone overgrowth with consequent nerve impingement may include hearing loss, chronic facial pain, hydrocephalus, peripheral nerve entrapment, and spinal stenosis. (bmj.com)
- Hereditary and acquired chronic pancreatitis are diseases that are rarely diagnosed early in their course. (nih.gov)
- Multiple sclerosis (MS) is a chronic disabling disease with significant implications for patients and society. (eurekaselect.com)
Diagnosis and treatment1
- Complicated feedback loops are involved in intricate regulation of virtually all body functions through the endocrine system. (slideshare.net)
- We combine in vivo genetic mouse models with in vitro tissue culture and molecular biology techniques to better understand the role of specific signaling pathways and transcription factors in regulation of bone and joint development as well as in the onset and progression of osteoarthritis. (rochester.edu)
- The regulation of theca cell-granulosa cell dialogue by endocrine and paracrine factors 19. (bookdepository.com)
- Since then, our understanding of the regulation of bone catabolism has advanced significantly with the identification of other key enzymes that regulate osteoclast formation, activation, and survival after their knockout in mice or recognition of mutations in them in humans. (aacrjournals.org)
- The classic form of Paget disease of bone typically appears in middle age or later. (medlineplus.gov)
- Early-onset Paget disease of bone is a less common form of the disease that appears in a person's teens or twenties. (medlineplus.gov)
- Classic Paget disease of bone occurs in approximately 1 percent of people older than 40 in the United States. (medlineplus.gov)
- Early-onset Paget disease of bone is much rarer. (medlineplus.gov)
- A combination of genetic and environmental factors likely play a role in causing Paget disease of bone. (medlineplus.gov)
- However, the influence of genetic and environmental factors on the development of Paget disease of bone remains unclear. (medlineplus.gov)
- Mutations in the SQSTM1 gene are the most common genetic cause of classic Paget disease of bone, accounting for 10 to 50 percent of cases that run in families and 5 to 30 percent of cases in which there is no family history of the disease. (medlineplus.gov)
- TNFRSF11A mutations cause the early-onset form of Paget disease of bone. (medlineplus.gov)
- Paget disease of bone disrupts the bone remodeling process. (medlineplus.gov)
- Researchers are looking for additional genes that may influence a person's chances of developing Paget disease of bone. (medlineplus.gov)
- A computed tomography scan displayed a marked widening of the diploic space of the calvaria with lytic and sclerotic regions ( Figure , A and B), which is pathognomonic of advanced Paget disease affecting the skull. (mja.com.au)
- The disease is named after Sir James Paget. (wikipedia.org)
- JFC has received royalties from Up To Date, Waltham, MA, for authorship on articles relating to Paget disease of bone (PDB). (bmj.com)
- We will recruit patients from our own Endocrine outpatient clinics and inpatient wards. (clinicaltrials.gov)
- iii) The protocol will serve as the basis for outpatient clinics that will function within the context of the pediatric and adult endocrine outpatient clinics: every eligible patient referred to the endocrine service from the NCI, NHLBI, and other NIH institutions and centers will be enrolled in this study, which for the first time will create an endocrine database for these patients. (knowcancer.com)
- Symptoms of some endocrine disorders are similar to many other conditions. (mainehealth.org)
- Symptoms and treatment for kidney disease vary depending the specifics of the case, but oftentimes, a diet change can help. (petmd.com)
- The symptoms of Wolman disease usually become apparent shortly after birth, usually during the first few weeks of life. (rarediseases.org)
- Additional symptoms may also occur in Wolman disease including yellowing of the skin, mucous membranes and whites of the eyes (jaundice), a persistent low-grade fever, and poor muscle tone (hypotonia). (rarediseases.org)
- Our facilities allow our experts to perform specialized testing not found in most medical centers, and patients are provided access to a wide variety of therapies using the most up to date medications to diagnose and treat both common and rare bone diseases. (clevelandclinic.org)
- To establish if the candidate gene is also causing possibly sporadic (not familial) cases of the disease, samples (blood and tissue) will be collected from patients with sporadic disease and will be analysed as above. (clinicaltrials.gov)
- AACE Members devote a significant part of their career to the evaluation and management of patients with endocrine disease. (aace.com)
- High calcitriol levels may also be seen in human disease states in patients not on supplementation. (wikipedia.org)
- Endocrine dysfunction is increasingly recognized as one of the most important aspects of quality of life issues, physical and psychosocial development and overall prognosis in pediatric patients diagnosed with neoplasms as well as in patients s/p bone marrow transplant throughout their lifespan. (knowcancer.com)
- The Pharmaceutical Benefits Scheme subsidises treatment only for patients with symptomatic disease. (mja.com.au)
- A strong case be made for also treating asymptomatic patients with involvement of long bones, vertebrae or base of skull, patients with significant osteolytic lesions, and perhaps all younger patients. (mja.com.au)
- Observations in patients and in animal models provide insights on the biomechanical consequences of these illnesses and the nature of the qualities of bone that determine its strength. (fluoridealert.org)
- Histomorphometric analysis of iliac crest biopsies from patients with fluorosis shows that osteosclerosis is the result of unbalanced coupling in favor of bone formation (Fig. 5A). (fluoridealert.org)
- In bone from fluoride-treated osteoporotic women and fluorotic patients, xray scattering shows crystals too large to be located inside the collagen fibrils (79). (fluoridealert.org)
- The book contains 19 chapters that are arranged by organ system and structured to cover the specific areas for a quick but in-depth understanding of diseases in aging patients. (springer.com)
- Diseases in the Elderly is the ultimate resource for geriatricians, medical students, primary care physicians, hospital doctors, geriatric nurses, and all other medical professionals treating and diagnosing diseases in elderly patients. (springer.com)
- At Stormont Vail Health, we treat patients of all ages with many types of endocrine disorders. (stormontvail.org)
- The PTH paradigm illustrated the possibility of stimulating bone formation in osteoporotic patients and opened the way for the development of bone forming agents and novel forms of PTH (e.g. (endocrine-abstracts.org)
- For example, inhibition of this pathway by blocking the action of sclerostin represents a very promising novel approach to stimulating bone formation in patients with osteoporosis. (endocrine-abstracts.org)
- Diagnosis is incidental in the majority of patients, with an elevated serum alkaline phosphatase raising suspicion for disease. (bmj.com)
- The organizations work together to eliminate the challenges that rare disease patients face. (rarediseases.org)
- NORD's natural history studies platform empowers patients and families to drive research and eliminate some of the unknowns that still exist in rare diseases," said NORD President and CEO Peter L. Saltonstall. (rarediseases.org)
- We are glad to be working with the Fibrous Dysplasia Foundation on this project and look forward to capturing the diverse experiences of patients living with this complex disease. (rarediseases.org)
- Patients can have one or many features of the disease, and these features can occur in any combination. (rarediseases.org)
- Gough AK, Lilley J, Eyre S, Holder RL, Emery P. Generalised bone loss in patients with early rheumatoid arthritis. (springer.com)
- Svensson B, Boonen A, Albertsson K, van der Heijde D, Keller C, Hafström I. Low-dose prednisolone in addition to the initial disease-modifying antirheumatic drug in patients with early active rheumatoid arthritis reduces joint destruction and increases the remission rate: a two-year randomized trial. (springer.com)
- Two-thirds of patients received endocrine therapy for first-line treatment. (rti.org)
- CONCLUSION: Patients prescribed endocrine therapy had longer TTP and OS than patients prescribed chemotherapy in the first- and second-line settings. (rti.org)
- Disease progression was less than a year regardless of treatment type and line of therapy, indicating a need for treatments that delay progression without affecting quality of life among these patients. (rti.org)
- Often patients are seen in conjunction with the endocrine surgeon, and cytopathologists are present at the bedside for FNAs. (umms.org)
- Fellows see patients weekly in our general endocrine clinic. (umms.org)
Osteoporosis and metabolic bone diseases1
- The relationship between bone-related proteins such as osteocalcin and osteoprotegerin and vascular disease is of special interest. (elsevier.es)
- Determination of bone Gla protein (osteocalcin) by enzyme-linked immunosorbent assay. (thefreedictionary.com)
- Osteocalcin or bone Gla protein (BGP) is a vitamin K-dependent, low-molecular-mass (5800 Da), 49 amino acid peptide synthesized by osteoblasts [1, 2]. (thefreedictionary.com)
- The Osteoporosis & Bone Clinic focuses on the treatment and prevention of a wide range of skeletal issues caused by osteoporosis. (clevelandclinic.org)
- Skeletal fluorosis results from a prolonged ingestion of fluoride causing bone pain, stiffness, and rigidity and possible deformities of the spine and limbs (69). (fluoridealert.org)
- Osteoarthritis may result from changes in bone shape that alter normal skeletal mechanics. (wikipedia.org)
- Bone remodelling is a highly conserved and regulated process that controls bone homeostasis and maintains skeletal structural integrity. (biologists.org)
- Redistribution indicates the existence of coronary steal and the presence of ischemic coronary artery disease. (wikipedia.org)
- GOAL : Normal Versus Abnormal (Endocrine). (slideshare.net)
- The abnormal bone formation is associated with recruitment of abnormal blood vessels, forcing the cardiovascular system to work harder (pump more blood) to ensure adequate circulation. (wikipedia.org)
- Feline urinary tract disease is a general term for disorders characterized by blood in the urine, difficult or painful urination, abnormal, frequent passage of urine, urinating in inappropriate. (petmd.com)
- 13. Lee WT, Jiang J. The resurgence of the importance of vitamin D in bone health. (scielo.org.za)
- Direct demonstration that the vitamin K-dependent bone Gla protein is incompletely [gamma]-carboxylated in humans. (thefreedictionary.com)
- Low levels of vitamin D have been associated with higher risks of some autoimmune diseases, and may make people more susceptible to infection. (bio-medicine.org)
- Heaney is a member of the Endocrine Society's task force on vitamin D guidelines. (bio-medicine.org)
- Key bone techniques that I am utilizing include high-resolution peripheral quantitative computed tomography (HR-pQCT) for the in vivo assessment of bone microarchitecture, microindentation for the estimation of cortical bone material strength properties, and 1H-magnetic resonance spectroscopy for the measurement of marrow adiposity characteristics. (massgeneral.org)
- This bone marrow film at 400X magnification demonstrates a complete absence of hemopoietic cells. (medscape.com)
- These data reinforce the need for marked vigilance in ensuring proper screening and management of long-term survivors of bone marrow transplantation. (medscape.com)
- Each case study reviews how the patient was managed, details the reasons why various tests and treatments-many only recently available-were carried out, and provides references to ensure that those novel methodologies can be easily translated into the endocrine specialist's daily practice. (barnesandnoble.com)
- Studies suggest that genetic variations in certain regions of chromosome 2, chromosome 5, and chromosome 10 appear to contribute to disease risk. (medlineplus.gov)
- There is a strong genetic component, and 15%-20% of those affected have a first-degree relative with the disease. (mja.com.au)
- Genetic and biochemical evidence indicates that CESD and Wolman disease are distinguished by residual lysosomal acid lipase activity. (rarediseases.org)
- General Endocrine Clinic. (umms.org)