Bone diseases. Medical search

Diseases of BONES.

A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.

The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.

Bone loss due to osteoclastic activity.

The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.

Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.

Tumors or cancer located in bone tissue or specific BONES.

Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.

Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.

The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.

Dissolution of bone that particularly involves the removal or loss of calcium.

A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.

The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.

Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.

A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.

A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM.

Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.

A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.

Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.

An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.

Breaks in bones.

Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.

A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.

Syndromes of bone destruction where the cause is not obvious such as neoplasia, infection, or trauma. The destruction follows various patterns: massive (Gorham disease), multicentric (HAJDU-CHENEY SYNDROME), or carpal/tarsal.

The process of bone formation. Histogenesis of bone including ossification.

A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.

A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.

Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.

The largest of three bones that make up each half of the pelvic girdle.

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.

A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.

A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.

A VITAMIN D that can be regarded as a reduction product of vitamin D2.

Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.

The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.

Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)

The grafting of bone from a donor site to a recipient site.

Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.

Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.

Diseases of the bones related to hyperfunction or hypofunction of the endocrine glands.

A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.

Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.

Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.

Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.

Abnormally high level of calcium in the blood.

Stable strontium atoms that have the same atomic number as the element strontium, but differ in the atomic weight. Sr-84, 86, 87, and 88 are the stable strontium isotopes.

The longest and largest bone of the skeleton, it is situated between the hip and the knee.

Death of a bone or part of a bone, either atraumatic or posttraumatic.

A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.

A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.

A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).

Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).

Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.

A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.

A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.

A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.

Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.

Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.

A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.

Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.

Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.

A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher.

An abnormal hardening or increased density of bone tissue.

Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).

Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.

A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.

A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.

The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.

X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.

The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.

One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.

Bone diseases caused by pathogenic microorganisms.

COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.

Inorganic compounds that contain TECHNETIUM as an integral part of the molecule. Technetium 99m (m=metastable) is an isotope of technetium that has a half-life of about 6 hours. Technetium 99, which has a half-life of 210,000 years, is a decay product of technetium 99m.

A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.

Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.

Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.

Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.

Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.

A coronary vasodilator agent.

A circular structural unit of bone tissue. It consists of a central hole, the Haversian canal through which blood vessels run, surrounded by concentric rings, called lamellae.

Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.

A condition of an abnormally low level of PHOSPHATES in the blood.

Inorganic salts of phosphoric acid.

Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.

The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.

Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).

AMINO ACIDS composed of GLYCINE substituted at the nitrogen rather than the usual carbon position, resulting in the loss of HYDROGEN BONDING donors. Polymers of these compounds are called PEPTOIDS.

A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.

Formation of stones in the KIDNEY.

Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)

Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.

Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia.

The spinal or vertebral column.

Excision of one or more of the parathyroid glands.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

The bone that forms the frontal aspect of the skull. Its flat part forms the forehead, articulating inferiorly with the NASAL BONE and the CHEEK BONE on each side of the face.

A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.

An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.

A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.

The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.

VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.

A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.

Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.

Elements of limited time intervals, contributing to particular results or situations.

Tomography using x-ray transmission and a computer algorithm to reconstruct the image.

A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.

Local surroundings with which cells interact by processing various chemical and physical signals, and by contributing their own effects to this environment.

A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.

Pathologic deposition of calcium salts in tissues.

Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.

A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.

A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.

The bones of the free part of the lower extremity in humans and of any of the four extremities in animals. It includes the FEMUR; PATELLA; TIBIA; and FIBULA.

A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.

Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.

Removal of bone marrow and evaluation of its histologic picture.

Fractures of the femur.

The five cylindrical bones of the METACARPUS, articulating with the CARPAL BONES proximally and the PHALANGES OF FINGERS distally.

Inorganic or organic compounds that contain the basic structure RB(OH)2.

A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)

A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.

Tumors or cancer of the human BREAST.

The five long bones of the METATARSUS, articulating with the TARSAL BONES proximally and the PHALANGES OF TOES distally.

A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).

The seven bones which form the tarsus - namely, CALCANEUS; TALUS; cuboid, navicular, and the internal, middle, and external cuneiforms.

Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.

CCR receptors with specificity for a broad variety of CC CHEMOKINES. They are expressed at high levels in MONOCYTES; tissue MACROPHAGES; NEUTROPHILS; and EOSINOPHILS.

A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.

Cholecalciferols substituted with two hydroxy groups in any position.

The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.

Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.

An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.

The TARSAL BONES; METATARSAL BONES; and PHALANGES OF TOES. The tarsal bones consists of seven bones: CALCANEUS; TALUS; cuboid; navicular; internal; middle; and external cuneiform bones. The five metatarsal bones are numbered one through five, running medial to lateral. There are 14 phalanges in each foot, the great toe has two while the other toes have three each.

Tumors or cancer of the PROSTATE.

LDL-receptor related protein that combines with FRIZZLED RECEPTORS at the cell surface to form receptors that bind WNT PROTEINS. The protein plays an important role in the WNT SIGNALING PATHWAY in OSTEOBLASTS and during EMBRYONIC DEVELOPMENT.

An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.

The outer shorter of the two bones of the FOREARM, lying parallel to the ULNA and partially revolving around it.

A surgical specialty which utilizes medical, surgical, and physical methods to treat and correct deformities, diseases, and injuries to the skeletal system, its articulations, and associated structures.

A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.

Fibrous blood-filled cyst in the bone. Although benign it can be destructive causing deformity and fractures.

Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.

The giving of drugs, chemicals, or other substances by mouth.

The surgical removal of one or both ovaries.

A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.

A bone morphogenetic protein that is a potent inducer of BONE formation. It plays additional roles in regulating CELL DIFFERENTIATION of non-osteoblastic cell types and epithelial-mesenchymal interactions.

The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.

Progenitor cells from which all blood cells derive.

Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)

The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

Implantable fracture fixation devices attached to bone fragments with screws to bridge the fracture gap and shield the fracture site from stress as bone heals. (UMDNS, 1999)

The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).

Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.

A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).

Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions: a randomized, placebo-controlled trial. Protocol 18 Aredia Breast Cancer Study Group. (1/1036)

PURPOSE: To assess whether pamidronate can reduce the frequency of skeletal morbidity in women with lytic bone metastases from breast cancer treated with hormone therapy. PATIENTS AND METHODS: Three hundred seventy-two women with breast cancer who had at least one lytic bone lesion and who were receiving hormonal therapy were randomized to receive 90 mg of pamidronate or placebo as a 2-hour intravenous infusion given in double-blind fashion every 4 weeks for 24 cycles. Patients were evaluated for skeletal complications: pathologic fractures, spinal cord compression, irradiation of or surgery on bone, or hypercalcemia. The skeletal morbidity rate (the ratio of the number of skeletal complications to the time on trial) was the primary efficacy variable. Bone pain, use of analgesics, quality of life, performance status, bone tumor response, and biochemical parameters were also evaluated. RESULTS: One hundred eighty-two patients who received pamidronate and 189 who received placebo were assessable. The skeletal morbidity rate was significantly reduced at 12, 18, and 24 cycles in patients treated with 90 mg of pamidronate (P = .028, .023, and .008, respectively). At 24 cycles, the proportion of patients having had any skeletal complication was 56% in the pamidronate group and 67% in the placebo group (P = .027). The time to the first skeletal complication was longer for patients receiving pamidronate than for those given placebo (P = .049). There was no statistical difference in survival or in objective bone response rate. Pamidronate was well tolerated. CONCLUSION: Treatment with 90 mg of pamidronate as a 2-hour intravenous infusion every 4 weeks in addition to hormonal therapy significantly reduces skeletal morbidity from osteolytic metastases. (+info)

The aetiology of congenital angulation of tubular bones with constriction of the medullary canal, and its relationship to congenital pseudarthrosis. (2/1036)

It is suggested that there is a group of cases of congenital angulation of tubular bones in which the lesion is a defect of ossification of the primary cartilaginous anlage and in which neurofibromatosis is not implicated. It appears that in this group the prognosis with regard to the resolution of deformity and the prevention of pseudarthrosis with conservative treatment or relatively simple surgical procedures is better than that in the neurofibromatous type. (+info)

Massive pelvic and femoral pseudotumoral osteolysis secondary to an uncemented total hip arthroplasty. (3/1036)

A 51 year-old man developed an extensive osteolytic response to wear debris in an uncemented porous-coated total hip arthroplasty, with metal/polyethylene interface, which had been implanted eighteen years previously. This reaction, which involved the upper femur and the ilium, produced a mass which compressed the pelvic viscera. (+info)

Circulating biochemical markers of bone remodeling in uremic patients. (4/1036)

Chronic renal failure is often associated with bone disorders, including secondary hyperparathyroidism, aluminum-related low-turnover bone disease, osteomalacia, adynamic osteopathy, osteoporosis, and skeletal beta2-microglobulin amyloid deposits. In spite of the enormous progress made during the last few years in the search of noninvasive methods to assess bone metabolism, the distinction between high- and low-turnover bone diseases in these patients still frequently requires invasive and/or costly procedures such as bone biopsy after double tetracycline labeling, scintigraphic-scan studies, computed tomography, and densitometry. This review is focused on the diagnostic value of several new serum markers of bone metabolism, including bone-specific alkaline phosphatase (bAP), procollagen type I carboxy-terminal extension peptide (PICP), procollagen type I cross-linked carboxy-terminal telopeptide (ICTP), pyridinoline (PYD), osteocalcin, and tartrate-resistant acid phosphatase (TRAP) in patients with chronic renal failure. Most of the observations made by several groups converge to the conclusion that serum bAP is the most sensitive and specific marker to evaluate the degree of bone remodeling in uremic patients. Nonetheless, PYD and osteocalcin, in spite of their retention and accumulation in the serum of renal insufficient patients, are also excellent markers of bone turnover. The future generalized use of these markers, individually or in combination with other methods, will undoubtedly improve the diagnosis and the treatment of the complex renal osteodystrophy. (+info)

Cladribine activity in adult langerhans-cell histiocytosis. (5/1036)

Langerhans-cell histiocytosis (LCH) results from the accumulation of tissue histiocytes derived from the same progenitor cells as monocytes. Because cladribine is potently toxic to monocytes, we conducted a phase II trial of cladribine. Cladribine was administered to 13 LCH patients at 0.14 mg/kg per day by 2-hour intravenous infusion for 5 consecutive days, every 4 weeks for a maximum of six courses. Median age was 42 years (range, 19 to 72) and median pretreatment disease duration was 99 months (range, 6 to 252). One patient was untreated, one had received prior prednisone only, one prior radiation only, six prior radiation and chemotherapy, and four prior surgery, radiation, and chemotherapy. Seven patients had cutaneous involvement, six multifocal osseous, six pulmonary, two each with soft tissue and nodal involvement, and four had diabetes insipidus. Of 13 patients, 12 were evaluable for response and all for toxicity. After a median of three courses (range, 1 to 6), seven (58%) patients achieved complete responses (two pathologic and five clinical) and two (17%) patients achieved partial responses; overall response rate, 75%. Median response follow-up duration was 33 months (range, 1 to 65). Seven patients experienced grade 3 to 4 neutropenia. Only one patient had a documented infection, dermatomal herpes zoster. At a median follow-up of 42 months (range, 5 to 76), 12 patients remain alive and one patient has died. Thus, cladribine has major activity in adult LCH and warrants further investigation in both pediatric and adult LCH as a single agent and in combination with other drugs. (+info)

Osteoblast-specific gene expression after transplantation of marrow cells: implications for skeletal gene therapy. (6/1036)

Somatic gene therapies require targeted transfer of the therapeutic gene(s) into stem cells that proliferate and then differentiate and express the gene in a tissue-restricted manner. We have developed an approach for gene therapy using marrow cells that takes advantage of the osteoblast specificity of the osteocalcin promoter to confine expression of chimeric genes to bone. Adherent marrow cells, carrying a reporter gene [chloramphenicol acetyltransferase (CAT)] under the control of a 1.7-kilobase rat osteocalcin gene promoter, were expanded ex vivo. After transplantation by intravenous infusion, engrafted donor cells in recipient mice were detected by the presence of the transgene in a broad spectrum of tissues. However, expression of the transgene was restricted to osteoblasts and osteocytes, as established by biochemical analysis of CAT activity and immunohistochemical analysis of CAT expression at the single cell level. Our data indicate that donor cells achieved long-term engraftment in various tissues of the recipients and that the CAT gene under control of the osteocalcin promoter is expressed specifically in bone. Thus, transplantation of multipotential marrow cells containing the osteocalcin promoter-controlled transgene provides an efficacious approach to deliver therapeutic gene expression to osteoblasts for treatment of bone disorders or tumor metastasis to the skeleton. (+info)

Beta2-microglobulin and renal bone disease. (7/1036)

Dialysis-related amyloidosis (DRA) is characterized by amyloid deposition mainly in bone and joint structures, presenting as carpal tunnel syndrome, destructive arthropathy, and subchondral bone erosions and cysts. Beta2-microglobulin has been demonstrated to be a major constituent of amyloid fibrils. DRA occurs not only in patients undergoing long-term hemodialysis, but also in patients undergoing continuous ambulatory peritoneal dialysis. The incidence of this complication increases with the duration of dialytic therapy and the age of the patient. While a definitive diagnosis of DRA can be made only by histological findings, various imaging techniques often support diagnosis. The molecular pathogenesis of this complication remains unknown. Recent studies have, however, suggested a pathogenic role of a new modification of beta2-microglobulin in amyloid fibrils--that is, the advanced glycation end-products (AGEs) formed with carbonyl compounds derived from autoxidation of both carbohydrates and lipids ("carbonyl stress"). Therapy for DRA is limited to symptomatic approaches and surgical removal of amyloid deposits. High-flux biocompatible dialysis membranes could be used to delay DRA development. (+info)

Prostaglandins and bone: physiology and pathophysiology. (8/1036)

Prostaglandins (PGs) are potent stimulators of bone formation and resorption and are produced by bone cells. PGs also have inhibitory effects on fully differentiated osteoblasts and osteoclasts. This complex, multifunctional regulation is probably mediated by different PG receptors. Endogenous PGs in bone are produced largely by induction of COX-2, which is highly regulated by hormones and local factors. The development of specific agonists and antagonists for PG receptors and for COX-2 should allow us to define the physiologic and pathophysiologic roles of PGs more precisely and develop new therapeutic approaches to metabolic and inflammatory disorders of the skeleton. (+info)

... refers to the medical conditions which affect the bone. A bone disease is also called an "osteopathy", but because ... or Paget's disease of bone) Osteitis fibrosa cystica (or Osteitis fibrosa, or Von Recklinghausen's disease of bone) Osteitis ... ISBN 0-07-138076-0. "Paget's Disease of Bone". The Lecturio Medical Concept Library. Retrieved 27 August 2021. "Osteochondritis ... of bone Greenstick fracture Gout Hypophosphatasia Hereditary multiple exostoses Klippel-Feil syndrome Metabolic bone disease ...

https://en.wikipedia.org/wiki/Bone_disease

... is an abnormality of bones caused by a broad spectrum of disorders. Most commonly these disorders are ... McWilliams, D. A.; Leeson, S. (2001). "METABOLIC BONE DISEASE IN LIZARDS: PREVALENCE AND POTENTIAL FOR MONITORING BONE HEALTH ... replacement of phosphate often corrects or improves the metabolic bone disorder. Metabolic bone disease in captive reptiles is ... osteoporosis osteomalacia (adults) & rickets (children) osteitis fibrosa cystica Paget's disease of bone pyramiding (turtles) ...

https://en.wikipedia.org/wiki/Metabolic_bone_disease

An infectious bone disease is a bone disease primarily associated with an infection. An example is osteomyelitis. Root, Richard ... v t e (Articles with short description, Short description matches Wikidata, All stub articles, Musculoskeletal disease stubs, ... K. (1999). Clinical Infectious Diseases: A Practical Approach. Oxford University Press. p. 741. ISBN 9780195081039. Retrieved 5 ...

https://en.wikipedia.org/wiki/Infectious_bone_disease

An endocrine bone disease is a bone disease associated with a disorder of the endocrine system. An example is osteitis fibrosa ... There are many bone disorders such as osteoporosis, Paget's disease, hypothyroidism. Although there are many forms of bone ... The cells of our bone that is involved in bone formation and bone breakdown is osteoblast and osteoclast respectively. ... Osteoclasts are cells of bones that promote bone demineralization or bone resorption. In contrast, Osteoblast promotes calcium ...

https://en.wikipedia.org/wiki/Endocrine_bone_disease

... and does not spread from bone to bone. Rarely, a bone affected by Paget's disease can transform into a malignant bone cancer. ... Paget's Disease of Bone Overview - NIH Osteoporosis and Related Bone Diseases ~ National Resource Center (Webarchive template ... Charles, Julia F.; Siris, Ethel S.; Roodman, G. David (2018). "Paget Disease of Bone". Primer on the Metabolic Bone Diseases ... Bone scans are useful in determining the extent and activity of the condition. If a bone scan suggests Paget's disease, the ...

https://en.wikipedia.org/wiki/Paget's_disease_of_bone

In periodontal disease, not only does the bone that supports the teeth, known as alveolar bone, reduce in height in relation to ... Horizontal bone loss manifests as a somewhat even degree of bone resorption so that the height of the bone in relation to the ... The bone destruction patterns that occur as a result of periodontal disease generally take on characteristic forms. There are ... Carranza, FA: Bone Loss and Patterns of Bone Destruction. In Newman, MG; Takei, HH; Carranza, FA; editors: Carranza's Clinical ...

https://en.wikipedia.org/wiki/Bone_destruction_patterns_in_periodontal_disease

... bone modeling) and bone structure and function during adulthood (bone remodeling). As a result, bone abnormalities are found ... Chronic Kidney Disease-Mineral and Bone Disorder (NIDDKD) Current Concepts and Management Strategies in Chronic Kidney Disease- ... and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder: Synopsis of the Kidney Disease: Improving Global Outcomes ... Chronic kidney disease-mineral and bone disorder (CKD-MBD) is one of the many complications associated with chronic kidney ...

https://en.wikipedia.org/wiki/Chronic_kidney_disease-mineral_and_bone_disorder

... to detect bone diseases and tumors; to determine the cause of bone pain or inflammation. This test is to rule out other cysts ( ... Bone Grafting: Bone grafting is proceeded with after curettage; the empty cavity is transplanted with donor bone tissue, bone ... 2020). "3. Bone tumours: simple bone cyst". Soft Tissue and Bone Tumours: WHO Classification of Tumours. Vol. 3 (5th ed.). Lyon ... A unicameral bone cyst, also known as a simple bone cyst, is a cavity filled with a yellow-colored fluid. It is considered to ...

https://en.wikipedia.org/wiki/Unicameral_bone_cyst

... a disease that thins and weakens bones, resulting in low bone density and fractures. Estrogen deficiency plays an important ... low estrogen levels increase bone resorption via osteoclasts and osteocytes, cells that help with bone remodeling, making bones ... Office of the Surgeon General (US) (2004). Diseases of Bone. Office of the Surgeon General (US). Alswat KA (May 2017). "Gender ... Estrogen deficiency is also associated with an increased risk of cardiovascular disease, and has been linked to diseases like ...

https://en.wikipedia.org/wiki/Hypoestrogenism

The Journal of Bone and Mineral Research ( JBMR) , JBMRPlus, and the Primer on the Metabolic Bone Diseases and Disorders of ... Burning bone fat a key to better bone health". Science Daily. 18 May 2017. "Why are our bones full of fat? The secrets of bone ... high-fat diets induces low bone mineral density and reduces bone formation in rats". Journal of Bone and Mineral Research. 25 ( ... Report from the First European Meeting on Bone Marrow Adiposity (BMA 2015)". Bone. 93: 212-215. doi:10.1016/j.bone.2015.11.013 ...

https://en.wikipedia.org/wiki/Bone_marrow_adipose_tissue

Glorieux, Francis H.; Pettifor, John M.; Jüppner, Harald (2011). Pediatric Bone: Biology & Diseases. Academic Press. p. 46. ... Bilezikian, John P.; Raisz, Lawrence G.; Martin, T. John Martin (2008). Principles of Bone Biology. Academic Press. p. 610. ... v t e (Articles with short description, Short description is different from Wikidata, Endocrine diseases, All stub articles, ...

https://en.wikipedia.org/wiki/Chondrodysplasia_Blomstrand

Roodman GD, Windle JJ (February 2005). "Paget disease of bone". The Journal of Clinical Investigation. 115 (2): 200-208. doi: ... A slow virus disease is a disease that, after an extended period of latency, follows a slow, progressive course spanning months ... Slow viruses cause a variety of diseases, including cancer. §JC virus & BK virus only cause disease in immunocompromised ... and Paget's disease of bone (osteitis deformans), which may be associated with paramyxoviruses, especially the measles virus ...

https://en.wikipedia.org/wiki/Slow_virus

These include osteoporosis, high blood calcium due to cancer, bone breakdown due to cancer, Paget's disease of bone and ... allowing the bone-forming cells time to rebuild normal bone and allowing bone remodeling. Zoledronic acid has been found to ... "Paget's Disease of Bone". www.rheumatology.org. Retrieved 2015-07-09. Vondracek, S. F. (2010). "Managing osteoporosis in ... and for ten days following Aclasta in patients with Paget's disease of the bone. Monitoring for other mineral metabolism ...

https://en.wikipedia.org/wiki/Zoledronic_acid

... numerous antibiotics Bone disease (bone ALP): Paget's disease, osteosarcoma, bone metastases of prostatic cancer (High / very ... bone diseases such as Paget disease, liver diseases such as hepatitis, blood disorders, or other conditions. Elevated alkaline ... Other bone metastases Renal osteodystrophy Fractured bone Skeletal involvement of other primary diseases: Osteomalacia, rickets ... "Paget's Disease of Bone". The Lecturio Medical Concept Library. Retrieved 9 July 2021. L Tibi; A W Patrick; P Leslie; A D Toft ...

https://en.wikipedia.org/wiki/Elevated_alkaline_phosphatase

... or Paget's disease of bone) Osteitis fibrosa cystica (or Osteitis fibrosa, or Von Recklinghausen's disease of bone) Osteitis ... "Paget's Disease of Bone". The Lecturio Medical Concept Library. Retrieved 27 August 2021. Frawley, Ed. "Panosteitis or PANO" ( ... Osteitis is inflammation of bone. More specifically, it can refer to one of the following conditions: Osteomyelitis, or ... pubis Radiation osteitis Osteitis condensans ilii Panosteitis, a long bone condition in large breed dogs In horses, pedal ...

https://en.wikipedia.org/wiki/Osteitis

Metabolic bone disease (MBD) is a collective term for several common diseases/illnesses that can be fatal and is probably the ... "Metabolic Bone Disease MDB". Bearded Dragons World. July 2019. Retrieved 21 May 2022. "Bearded Dragon Egg Bound". Bearded ... Hypocalcemia is most often tied to metabolic bone disease. Low levels of calcium can result in twitching muscles, or seizures. ... Bearded dragons require UVB to enable vitamin D3 synthesis and to prevent illnesses like metabolic bone disease. Vitamin D3 is ...

https://en.wikipedia.org/wiki/Pogona

Osteogenic bone metastasis caused by carcinoma of prostate and breast Paget's disease of bone Myelofibrosis (primary disorder ... Camurati-Engelmann disease) SOST-related sclerosing bone dysplasias Sclerosis of the bones of the thoracic spine due to ... It makes bones heavier, but also more fragile. In those animal groups, osteosclerosis often occurs together with bone ... There are white portions of the bone which appear due to the increased number of bone trabeculae.[citation needed] In the ...

https://en.wikipedia.org/wiki/Osteosclerosis

"Osteoporosis Overview". NIH Osteoporosis and Related Bone Diseases National Resource Center. "Scientists discover new bone- ... A bone growth factor is a growth factor that stimulates the growth of bone tissue. Known bone growth factors include insulin- ... Osteoporosis is a bone disease where bone mass is less than the average and can increase fractures. Some causes that lead to ... and acts as a central component in the coupling of bone formation and its resorption during bone remodeling. Bone Morphogenic ...

https://en.wikipedia.org/wiki/Bone_growth_factor

"Preventing Falls and Related Fractures , NIH Osteoporosis and Related Bone Diseases National Resource Center". www.bones.nih. ... In fact, bone is a mineralized collagen matrix; if the mineral is dissolved out of bone, it becomes rubbery. Healing bone ... Weight-bearing stress on bone, after the bone has healed sufficiently to bear the weight, also builds bone strength. Although ... Infection is especially dangerous in bones, due to the recrudescent nature of bone infections. Bone tissue is predominantly ...

https://en.wikipedia.org/wiki/Bone_fracture

"Bone Mass Measurement: What the Numbers Mean , NIH Osteoporosis and Related Bone Diseases National Resource Center". www.bones. ... "Exercise for Your Bone Health , NIH Osteoporosis and Related Bone Diseases National Resource Center". www.bones.nih.gov. ... "Smoking and Bone Health , NIH Osteoporosis and Related Bone Diseases National Resource Center". www.bones.nih.gov. Retrieved ... Bone density, or bone mineral density, is the amount of bone mineral in bone tissue. The concept is of mass of mineral per ...

https://en.wikipedia.org/wiki/Bone_density

... brittle bone disease (osteogenesis imperfecta); cerebral palsy (CP); cleft palate or lip; club foot (talipes); dissociative ...

https://en.wikipedia.org/wiki/Kupenda_for_the_Children

"An undescribed disease of bone", but he had already been writing on haemochromatosis and he began studying this disease in ... Sheldon, J. H. (January 1929). "An undescribed disease of bone". British Journal of Surgery. 16 (63): 405-430. doi:10.1002/bjs. ... Sheldon, J. H. (July 1938). "Clinical Reports and Demonstrations: Section for the Study of Disease in Children. Arterial ...

https://en.wikipedia.org/wiki/Joseph_Harold_Sheldon

"Bone disease in primary hyperparathyrodism". Therapeutic Advances in Musculoskeletal Disease. 4 (5): 357-68. doi:10.1177/ ... Sprenger-Mähr H, Zitt E, Kronbichler A, Cejna M, Lhotta K (November 2019). "A hemodialysis patient with bone disease after ... The osteoclasts consume the trabecular bone that osteoblasts lay down and this front of reparative bone deposition followed by ... it is increasingly rare for primary hyperparathyroidism to present with accompanying bone disease. This is not the case in less ...

https://en.wikipedia.org/wiki/Brown_tumor

Metabolic Bone and Stone Disease. BEC Nordin, AG NEED, HA Morris: Churchill Livingstone, 1993. p 328-9 Principles and Practice ... The three-phase bone scan may be the most sensitive method of detecting early heterotopic bone formation. However, an ... Bone. 2022 Feb;155:116287. DOI: 10.1016/j.bone.2021.116287. PMID 34896358. Morley, John; Marsh, Sarah; Drakoulakis, Emmanuil; ... Heterotopic ossification (HO) is the process by which bone tissue forms outside of the skeleton in muscles and soft tissue. In ...

https://en.wikipedia.org/wiki/Heterotopic_ossification

"Bone disease in primary hypercalciuria". Clinical Cases in Mineral and Bone Metabolism. 5 (2): 118-126. ISSN 1724-8914. PMC ... Bone resorption involves the breaking down of bone tissue and the transfer of calcium ions into the blood. Bone resorption is ... The most studied disease is Dent's disease, which is attributed to a mutation in CLCN5 or OCRL1 genes. However, IH patients ... Bone loss is unique to nephroliths patients with IH, proposing it has an unidentified role in the increased bone fragility and ...

https://en.wikipedia.org/wiki/Idiopathic_hypercalcinuria

Couzin, Jennifer (2006). "Bone Disease Gene Finally Found". Science. 312 (5773): 514-515. doi:10.1126/science.312.5773.514b. ... In search of a gene linked to a poorly known bone disease known as Fibrodysplasia ossificans progressiva (FOP), scientist Fred ... This would go on to allow deeper research about the disease, and potentially allow for the development of a treatment for the ... disease. In May 2010, Medical editor Christine Soares proposed that a "modern all-points bulletin" may take the shape of what ...

https://en.wikipedia.org/wiki/All-points_bulletin

and other metabolic bone diseases. He has published over 400 scholarly articles and has delivered numerous prestigious ... He is the Director of the Centre for Bone and Periodontal Research and also holds the position of Senior Scientist at the ... He has been Director of the Centre for Advanced Bone and Periodontal Research, as well as Director of the Calcium Research ... He received the Lawrence G. Raisz Award (inaugural) of the American Society for Bone and Mineral Research (ASBMR) in 2010, the ...

https://en.wikipedia.org/wiki/David_Goltzman

Weissman, Barbara N (2009). Imaging of Arthritis and Metabolic Bone Disease. Elsevier Health Sciences. p. 17. ISBN 978-0-323- ... A bone scan or bone scintigraphy /sɪnˈtɪɡrəfi/ is a nuclear medicine imaging technique of the bone. It can help diagnose a ... Person undergoing a bone scan on the skull A patient undergoing a SPECT bone scan. Although bone scintigraphy generally refers ... Weissman, Barbara N. (2009). Imaging of arthritis and metabolic bone disease. Philadelphia, PA: Mosby/Elsevier. p. 18. ISBN ...

https://en.wikipedia.org/wiki/Bone_scintigraphy

Michou L, Collet C, Laplanche JL, Orcel P, Cornélis F (2006). "Genetics of Paget's disease of bone". Joint Bone Spine. 73 (3): ... "Paget disease of bone: mapping of two loci at 5q35-qter and 5q31". Am. J. Hum. Genet. 69 (3): 528-43. doi:10.1086/322975. PMC ... which cause Paget's disease of bone". Biochem. Soc. Trans. 32 (Pt 5): 728-30. doi:10.1042/BST0320728. PMID 15493999. S2CID ... a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. Male and ...

https://en.wikipedia.org/wiki/Sequestosome_1

Metabolic Bone Disease and Related Research. 5 (4): 206. doi:10.1016/0221-8747(84)90034-1. ISSN 0221-8747. Frootko, N. J. (1985 ... In 1984 Frootko, working with James Triffitt (now Emeritus Professor of Bone Metabolism in Oxford), was able to demonstrate new ... bone formation in human demineralised allograft ossicles used to reconstruct the ossicular chain. Unfortunately this and all ... using allografts were abandoned in 1987 because of the potential risk of transmission of HIV and Creutzfeldt-Jakob disease from ...

https://en.wikipedia.org/wiki/Nicholas_John_Frootko

Deborah Bone, 51, English mental health nurse, inspired Disco 2000, multiple myeloma. Antonio Brack Egg, 74, Peruvian ecologist ... Joseph Sargent, 89, American film director (The Taking of Pelham One Two Three, MacArthur, Jaws: The Revenge), heart disease. ... "Mental health nurse Deborah Bone, MBE, who inspired Pulp's 'Disco 2000' dies aged 51". Independent.co.uk. Archived from the ... Bill J. Dukes, 87, American politician, member of the Alabama House of Representatives (1994-2010), Parkinson's disease. Claude ...

https://en.wikipedia.org/wiki/Deaths_in_December_2014

Bone morphogenetic protein (BMP) cell signaling plays a key role in diverse aspects of cardiac differentiation and ... Atrioventricular conduction disease (AV block) describes impairment of the electrical continuity between the atria and ... ISBN 978-0-7216-0240-0. Benson DW (October 2004). "Genetics of atrioventricular conduction disease in humans". The Anatomical ... seen in BMP and Alk3 are associated with some cardiovascular diseases like Ebstein's anomaly and AV conduction disease. The AV ...

https://en.wikipedia.org/wiki/Atrioventricular_node

Benji presents her with the bone he received from Bill and she follows him back to the Chapman house where Mary brushes her, ... Chapman tells his despondent children that Benji carries diseases and forbids them from keeping him as a pet in spite of ... At Bill's Café, Benji wakes Bill from his morning nap and receives a bone as payment. Returning home, Benji finds three ...

https://en.wikipedia.org/wiki/Benji_(1974_film)

Dunne EF, Park IU (December 2013). "HPV and HPV-associated diseases". Infectious Disease Clinics of North America. 27 (4): 765- ... bone fractures, and (rarely) leakage of urine or feces from the vagina. Bleeding after douching or after a pelvic exam is a ... Papillomavirus-associated diseases, Sexually transmitted diseases and infections, Wikipedia medicine articles ready to ... In advanced disease, metastases may be present in the abdomen, lungs, or elsewhere. Symptoms of advanced cervical cancer may ...

https://en.wikipedia.org/wiki/Cervical_cancer

The Friends of Benjamin Franklin House (the organization responsible for the restoration) note that the bones were likely ... Infectious disease deaths in Pennsylvania, Les Neuf Sœurs, Masonic Grand Masters, Members of the American Philosophical Society ... Respiratory disease deaths in Pennsylvania, Rhetoric theorists, Scientists from Boston, Scientists from Philadelphia, Signers ... time apart is that he may have blamed her for possibly preventing their son Francis from being inoculated against the disease ...

https://en.wikipedia.org/wiki/Benjamin_Franklin

Robotic Assistant Robot for Bone-Fracture Reposition Surgery, which replaces assistant surgeons who align the broken bone to ... Microrobot moving controlled through blood vessel for drug delivery and treatment of coronary artery disease such as CTO( ... An articulated robotic arm to carry a human & respiration synchronization method) Surgeon-Robot Interaction for Bone-Fracture ...

https://en.wikipedia.org/wiki/Robot_research_initiative

When blood in the joint is broken down by enzymes in the body, the bone in that area is also degraded, this exerts a lot of ... pain upon the person affected by the disease.[medical citation needed] One therapeutic conundrum is the development of ...

https://en.wikipedia.org/wiki/Haemophilia_A

Bone, James (2016). The Curse of Beauty: The Scandalous and Tragic Life of Audrey Munson, America's First Supermodel. New York ... Believed to have contracted it from a contaminated needle, she became one of the first famous women to die of the disease. Her ... becoming one of the first famous women to die of the disease. Her funeral was held on November 23 at a small funeral home in ...

https://en.wikipedia.org/wiki/Gia_Carangi

1 to lung and 1 to bone. By the end of the study, 47 individuals had no evidence of disease and 2 had died of unknown causes. ... In a study of 25 individuals with EPC, 14 had in situ and 11 had invasive disease with 6 of the invasive tumors rated as high ... In a study of 25 individuals with EPC, 14 had in situ and 11 had invasive disease with 6 of the invasive tumors rated as high ... In a follow-up 8 to 104 months (mean: 47 months) after diagnoses of 29 cases, 5 developed recurrent disease 1.5 to 7 (mean: 3.3 ...

https://en.wikipedia.org/wiki/Papillary_carcinomas_of_the_breast

These relics consist in some cases of a solitary tooth or a splinter of bone. In the Middle Ages, objects claimed to be her ... Patron of Dentists and Dental Diseases] (in Spanish). Dental World. Retrieved 21 December 2017. Catholicism portal Medicine ...

https://en.wikipedia.org/wiki/Saint_Apollonia

p. 91) This involves inserting the needles into the periosteum - almost all the way down to the bone. Reinventing Acupuncture: ... Atlas of Acupuncture (1966), 13 reprints The Meridians of Acupuncture (1964), also in Italian The Treatment of Disease by ... Acupuncture: Cure of Many Diseases (1971) 1st edition; (1972) Pan edition; (1972) USA edition; (1972) Revised edition, also in ...

https://en.wikipedia.org/wiki/Felix_Mann

The animal bones typically that the people of Kibiro relied on fish for a source of food as well as on domesticated cows, goats ... Good, Charles M (1972). "Salt, Trade, and Disease: Aspects of Development in Africa's Northern Great Lakes Region". The ... The majority of the animal remains were bones that appeared to be well preserved but were too shattered to be able to diagnosed ... There was also animal bones that were discovered at the deposit. With all of this being tied together with the other evidence ...

https://en.wikipedia.org/wiki/Kibiro

It beats old age, disease, or falling down the cellar stairs. To be a Gringo in Mexico--ah, that is euthanasia!" Skeptic Joe ... and was reprinted in the anthology Men Without Bones. Bierce reappears in the future on Mount Shasta in Robert Heinlein's ...

https://en.wikipedia.org/wiki/Ambrose_Bierce

The Firestone Institute for Respiratory Health (FIRH) is a center for the investigation and treatment of respiratory diseases. ... for asthma and COPD Mechanisms of airway hyperresponsiveness and airway remodelling Trafficking and lung homing of bone-marrow ...

https://en.wikipedia.org/wiki/Firestone_Institute_for_Respiratory_Health

Sometimes, they may cause disease or comfort. The Ati from Negros refer to them as taglugar or tagapuyo, which literally means ... Some jewelry objects involve plants such as flowers, while others use animal bones; particularly the teeth of pigs. Ati are ...

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... is primarily made from cattle and pig bones; however, to prevent the spread of Creutzfeldt-Jakob disease, the skull ... Human bone char, referred to as "bone charcoal", is mentioned in Thomas Pynchon's novel The Crying of Lot 49. The bones come ... Modern alternatives to bone char include activated carbon and ion-exchange resins. Bone char is also used as a black pigment ... The production of bone char was featured on the Discovery Channel's TV series Dirty Jobs, on episode 24 of season 4, "Bone ...

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The back of the neck presses against the pubic bone and its chin leaves its chest, extending the neck - as if to look up, and ... The U.S. Centers for Disease Control and Prevention (CDC) has led an initiative to improve woman's health previous to ... Martin RJ, Fanaroff AA, Walsh MC (2014). Fanaroff and Martin's Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant. ... "Recent Declines in Induction of Labor by Gestational Age". Centers for Disease Control and Prevention. Retrieved 9 May 2018. ...

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The early discourses also state that practicing mindfulness of feeling can be a way of dealing with physical pain and disease. ... from a fresh corpse to bone dust). According to Anālayo, the sources indicate that the practice could have been done in a ...

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In the future, case studies indicate that bone marrow metastases will likely play a larger role in the diagnosis and management ... SRCC cancers are usually diagnosed during the late stages of the disease, so the tumors generally spread more aggressively than ... Dittus C, Mathew H, Malek A, Negroiu A (December 2014). "Bone marrow infiltration as the initial presentation of gastric signet ... ISBN 978-1-60831-434-8. "Office of Rare Diseases Research: Diffuse Gastric Cancer". National Institute of Health. National ...

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In 2010, updated guidelines were issued by the Infectious Diseases Society of America, recommending use of cefepime, ... suppresses the bone marrow from producing blood cells).[citation needed] The Multinational Association for Supportive Care in ... Guidelines issued in 2002 by the Infectious Diseases Society of America recommend the use of particular combinations of ...

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MacDonald BT, Tamai K, He X (July 2009). "Wnt/β-catenin signaling: components, mechanisms, and diseases". Dev. Cell. 17 (1): 9- ... Coluzzi F, Mandatori I, Mattia C (September 2011). "Emerging therapies in metastatic bone pain". Expert Opin Emerg Drugs. 16 (3 ... may help prevent clinical recurrence of the disease after surgery, but much more work is needed before an adequate treatment ... techniques with therapeutics targeting catenin-associated elements of cancer might be most effective in treating the disease. ...

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She worked closely with the Zoological Society's pathologist to identify diseases and became expert at treating sick animals, ... Indexed at http://library.zsl.org/ Bone, James. 1931. Letters dated 21 April 23 April and 18 May to Joan Procter, in Girton ...

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20 bones per limb. Bones are connected to muscles via tendons and other bones via ligaments. Bones are also used to store ... Diseases and surgery of the globe and orbit". In Gilger, BC (ed.). Equine Ophthalmology (3rd ed.). John Wiley & Sons. p. 151. ... Ligaments attach bone to bone or bone to tendon, and are vital in stabilizing joints as well as supporting structures. They are ... bones found on each of the legs, on either side of the cannon bone (8 total); partially vestigial, these bones support the ...

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Artists Domino Bones, 808 State, Elbow, Stephen Fretwell, Nine Black Alps, Badly Drawn Boy, Johnny Marr and The Healers, Doves ... Sadly they both succumbed to the disease. In 2007 shortly after the concert, Tom and Stephen left Versus Cancer to pursue other ... the decision was finalised to put on a small charity gig to raise some money to raise awareness of the disease. Later it was ...

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Disease processes that FDC may contribute include primary FDC-tumor, chronic inflammatory conditions, HIV-1 infection ... Unlike dendritic cells (DC), FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin. ... Aguzzi A, Kranich J, Krautler NJ (2014). "Follicular dendritic cells: origin, phenotype, and function in health and disease". ... and function in health and disease". Trends in Immunology. 35 (3): 105-113. doi:10.1016/j.it.2013.11.001. ISSN 1471-4906. PMID ...

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There are millions of B and T cells inside the body, both created within the bone marrow and the latter matures in the thymus, ... It is possible, but uncommon for molecular mimicry to lead to an autoimmune disease. Superantigens are composed of viral or ... If autoreactive cells escape clonal deletion in either the thymus or the bone marrow, there are mechanisms in the periphery ... B cells demonstrating high affinity for self antigen can undergo clonal deletion within the bone marrow. This occurs after the ...

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While all Cushing's disease gives Cushing's syndrome, not all Cushing's syndrome is due to Cushing's disease. Several possible ... Rapid weight gain Moodiness, irritability, or depression Muscle and bone weakness Memory and attention dysfunction Osteoporosis ... This etiology is called ectopic or paraneoplastic Cushing's disease and is seen in diseases such as small cell lung cancer. ... Cushing's disease is rare; a Danish study found an incidence of less than one case per million people per year. However, ...

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Tetracycline was being used by Nubians, based on bone remains between 350 AD and 550 AD. The antibiotic was in wide commercial ... disease, divine intervention, Hezekiah's surrender) as to why the Assyrians failed to take the city and withdrew to Assyria. ...

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The National Museum is dedicated to the history of Tanzania; most notably, it exhibits some of the bones of Paranthropus boisei ... Flooding incidents destroy bridges and roads, disrupt transportation, increase risk of diseases such as cholera and skin ...

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... and peripheral bone mineral density, lifetime milk consumption, and lifetime physical activity, in elderly mothers and their ... she was the director and department head of preventive oncology at the National Center of Tumor Diseases (NCT) and German ...

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Learn about different kinds of bone problems and how genetics can play a role. ... Bone diseases increase your risk for breaking bones. ... Pagets disease of bone makes them weak *Bones can also develop ... Bone diseases can make bones easy to break. Different kinds of bone problems include:. *Low bone density and osteoporosis, ... After about age 20, you can lose bone faster than you make bone. To have strong bones when you are young, and to prevent bone ...

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Osteolytic bone disease is highly common in multiple myeloma, with as many as 80% of patients presenting with detectable ... Unlike bisphosphonates, such as zoledronic acid - which is the most common treatment for bone disease in multiple myeloma - ... Cite this: Denosumab Shows Benefits in Multiple Myeloma Bone Disease - Medscape - Jun 27, 2017. ... provide denosumab the potential to be the new standard of care for multiple myeloma-related bone disease," said Evangelos ...

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JavaScript is disabled for your browser. Some features of this site may not work without it ...

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Bones. » Cranio Facial. » Metabolic Bone Diseases. Metabolic Bone Diseases. Bone multicellular units. Calcium supplements. ... Categories Bones, Cranio Facial Tags cranio-facial Menu for the Tibia / Tibia Frx ...

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Julie Cisler needs your support for Melody Kittys Brittle Bone Disease ... more commonly known as Brittle Bone Disease.. Brittle Bone disease is a rare genetic disorder that affects human children and ... But this most recent injury led to an x-ray consult from the U of M, and now we know that she has actually broken bones in her ... The bones are deficient in collagen, making them prone to breakage. Melody needs orthopedic surgery to help mend this fracture ...

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The orthopedic surgeon has 2 major tasks to perform when treating patients who develop bone metastases. The first task is to ... encoded search term (Metastatic Bone Disease) and Metastatic Bone Disease What to Read Next on Medscape ... Development of a scoring system for survival following surgery for metastatic bone disease. Bone Joint J. 2021 Nov. 103-B (11): ... Metastatic Bone Disease Clinical Presentation. Updated: Mar 09, 2022 * Author: Howard A Chansky, MD; Chief Editor: Harris ...

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We report on two patients presenting with CF-related bone disease in the past year who were subsequently found to have ... Celiac disease may occur at a higher frequency in patients with CF than the general population, and symptoms of these ... Clinicians should consider screening for celiac disease in patients with CF who have low BMD, worsening BMD in the absence of ... Because adherence to a gluten-free diet may improve BMD in patients with celiac disease, this could have important implications ...

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The basis of the pathogenesis of myeloma-related bone disease is the uncoupling of the bone-remodeling process. The interaction ... Herein, we provide an insight into the underlying pathogenesis of bone disease and discuss possible directions for future ... constitute a promising approach in the management of myeloma-related bone disease and several novel agents are currently under ... During the last years, osteocytes have emerged as key regulators of bone loss in myeloma through direct interactions with the ...

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Proceedings of the international workshop on kashin-beck disease and non-communicable diseases ... Technical consultation on the effects of hormonal contraception on bone health : summary report, Geneva, Switzerland, 20-21 ...

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... award is open to medical doctors who have made significant progress and contribution to the field of bone clinical bone disease ...

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Diseases of Bone and Mineral Metabolism - free book at E-Books Directory. You can download the book or read it online. It is ... ACS encompass a spectrum of unstable coronary artery disease... (7069 views). Diabetes in Pregnancy. - RCOG Press. ... From the table of contents: Anatomy and Ultrastructure of Bone; Calcium and Phosphate Homeostasis; Vitamin D System in Mineral ...

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Vitamin D supplements do not help improve bone mineral density in healthy adults, researchers have found. The commonly ...

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... may help maintain bone health as people age. However, most American adults do not engage in the recommended minimum levels of ... Bone 1997;21(4):363-7. CrossRef PubMed. * US Department of Health and Human Services, Centers for Disease Control and ... DXA is the gold standard for assessing bone mineral content and bone mineral density (16). The left hip has been proposed as ... Prevalence and trends in low femur bone density among older US adults: NHANES 2005-2006 compared with NHANES III. J Bone Miner ...

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As Simplemost reports, The 70-pound sulcata tortoise was born with a metabolic bone disease that halted his leg bones from ... In reptiles, metabolic bone disease can be the result of an imbalance between calcium and phosphorus or from living in a cool ... A 70-Pound Sulcata Tortoise With a Rare Disease Can Now Walk Thanks to a Wheelchair. ...

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Osteomyelitis of Parietal Bone in Melioidosis. Emerging Infectious Diseases. 2007;13(8):1257. doi:10.3201/eid1308.070479.. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... usually part of a disseminated infection involving metaphyseal regions of long bones and vertebral bodies. Localized bone ... To the Editor: In Europe and the United States, melioidosis is a rare disease, with no cases reported thus far from Slovenia. ...

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Getting the right diagnosis can be difficult and many patients with bone marrow failure diseases are often misdiagnosed or ... Getting the right diagnosis can be difficult and many patients with bone marrow failure diseases are often misdiagnosed or ... Home , Donate , Diseases , Treatments , Education , Support , Patients , Caregivers , Professionals , Articles , Research , ...

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Westendorfs Skeletal Development and Regeneration Research Lab at Mayo Clinic studies histone deacetylases in bone diseases to ... Histone Deacetylases in Bone Development and Bone Diseases. Open pop-up dialog box Cortical bone ... Histone deacetylase 3 is required for maintenance of bone mass during aging. Bone. 2013; doi:10.1016/j.bone.2012.10.015. ... Defining osteoblast and adipocyte lineages in the bone marrow. Bone. 2019; doi:10.1016/j.bone.2018.05.019. ...

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Two-year-old beats rare genetic disease after receiving bone marrow from her brother in Abu Dhabi. Eman was born with rare ... The only permanent curative treatment for these types of diseases is early diagnosis and bone marrow transplantation (BMT). ... Two-year-old beats rare genetic disease after receiving bone marrow from her brother in Abu Dhabi. ... All the tests at showed her brother was the best donor for her and he was fit for donating bone marrow for his sister," Dr ...

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Paediatric studies on bone mineral density (BMD) with rheumatic diseases demonstrated conflicting results.5,-,8 The confusion ... Bone density in children and adolescents with rheumatic diseases. Preliminary results of selective measurement of trabecular ... Participants had higher disease activity at diagnosis compared with non-participants (mean SLE Disease Activity Index (SLEDAI) ... Childhood and adolescence are crucial periods of bone mass accrual. More than 90% of the peak bone mass should be accrued by ...

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Frankel BM, Jones T, Wang C. Segmental polymethylmethacrylate-augmented pedicle screw fixation in patients with bone softening caused by osteoporosis and metastatic tumor involvement: a clinical evaluation. (medscape.com)
This study aimed to determine whether current physical activity is related to bone density in a racially/ethnically diverse sample after controlling for age, sex, body mass index, poverty-income ratio, tobacco use, vitamin D and calcium intake, and use of osteoporosis medications. (cdc.gov)
Despite lower levels of activity, blacks and Hispanics were not more likely to have osteoporosis, and high levels of activity were significantly associated with higher bone density even when controlling for race/ethnicity and confounders. (cdc.gov)
We aimed to determine whether current physical activity is related to bone density in a racial/ethnically diverse sample of adults aged 40 to 80 years, after controlling for age, sex, body mass index (BMI), poverty-income ratio, tobacco use, vitamin D and calcium intake, and current osteoporosis treatment. (cdc.gov)
They also help treat birth defects related to bones and muscles as well as degenerative conditions like osteoporosis and muscular dystrophy. (vitals.com)
Although chronic kidney disease predisposes patients treated with denosumab to hypocalcemia, in this study, only the degree of lumbar osteoporosis significantly associated with denosumab-induced hypocalcemia. (renalandurologynews.com)
Depending on the stage of the disease, this includes evidence of bone marrow edema, lipocyte and bone cell necrosis, fibrosis, creeping substitution (new bone lying on dead bone), and the presence of osteoporosis [1]. (elsevier.com)
Despite the reported high prevalence of osteoporosis in the human immunodeficiency virus (HIV)-population, there have been no previous studies examining dairy calcium intake and bone mineral density (BMD) in HIV-subjects. (biomedcentral.com)
Adherence and persistence with bone-targeted therapy have been observed to be suboptimal when patients self-administer, both in osteoporosis prevention and in the treatment of bone metastases. (targetedonc.com)
With both oral and IV administration routes, the need for more frequent dosing in patients with metastatic bone disease (relative to osteoporosis treatment) can add to the compliance problem. (targetedonc.com)
Is osteoporosis a pediatric disease? (cdc.gov)
Thyrotoxicosis causes acceleration of bone remodelling and though it is one of the known risk factors for osteoporosis, the metabolic effects of thyroxine on bone are not well discussed. (who.int)
In addition, many patients have osteoporosis, likely from a combination of endocrine dysfunction, 25-hydroxy vitamin D deficiency, and bone marrow expansion. (medscape.com)
Evaluación del riesgo de fractura y su aplicaci'on en la detección de la osteoporosis postmenopáusica : informe de un grupo de estudio de la OMS. (who.int)
Evaluación del riesgo de fractura y su aplicación en la detección de la osteoporosis postmenopáusica : informe de un grupo de estudio de la OMS. (who.int)
The association between peripheral arterial disease (PAD) and osteoporosis in elderly men with type 2 diabetes mellitus (T2DM) remains unclear. (bvsalud.org)
Stunted adolescents suffered from low bone mass density and low stature adults suffered a high prevalence of osteoporosis. (who.int)
Osteoporosis, a disease in which bones grow weaker, threatens more than half of Americans over age 50," explained Ariel Anbar, a professor in ASU's Department of Chemistry and Biochemistry and the School of Earth and Space Exploration, and senior author of the study. (spaceref.com)
Growing prevalence of bone related diseases such as osteoporosis is driving growth of the external fixators market. (medgadget.com)
Ultrasonic measurements of the bone may offer a simple, non-invasive and radiation-free assessment of bone quality in osteoporosis and other metabolic diseases affecting the bone. (thieme-connect.de)
Teriparatide injection is used to treat osteoporosis (a condition in which the bones become thin and weak and break easily) in women who have undergone menopause ('change in life,' end of menstrual periods), who are at high risk of fractures (broken bones), and cannot use other osteoporosis treatments. (medlineplus.gov)
It is also used to increase bone mass in men with certain types of osteoporosis who are at high risk for having broken bones (fractures), and who cannot use other osteoporosis treatments. (medlineplus.gov)
Teriparatide injection is also used to treat osteoporosis in men and women who are taking corticosteroids (a type of medication that may cause osteoporosis in some patients) who are at high risk of fractures (broken bones), and cannot use other osteoporosis treatments. (medlineplus.gov)

Is it true that the gene(s) for celiac disease can be passed in donated bone marrow to someone without the disease? (cureceliacdisease.org)

Both cystic fibrosis (CF) and celiac disease can cause low bone mineral density (BMD) and fractures. (hindawi.com)
Children and adults with CF are at risk for low bone density and fractures due to multiple potential risk factors including vitamin D deficiency, delayed puberty, hypogonadism, pancreatic insufficiency causing malabsorption, compromised nutrition, glucocorticoid use, reduced physical activity, and possibly CF transmembrane conductance regulator (CFTR) dysfunction itself [ 2 , 3 ]. (hindawi.com)
Differences in the associations between PA and the prevention of bone loss and related fractures by race/ethnicity have been evaluated with conflicting results (11-13). (cdc.gov)
Hand surgeons also commonly work with patients who have fractures or broken bones from any kind of accident. (vitals.com)
We studied the vertebral fracture prevalence on low-dose chest computed tomography (CT) in male lung cancer screening participants and the association of fractures and bone density with chronic obstructive pulmonary disease (COPD) and smoking. (eur.nl)
On CT, vertebral fractures and bone density were measured. (eur.nl)
Fractures are more common in current smokers, who also have lower bone density. (eur.nl)
1 Thus, the prevention of SREs such as pathologic fractures and spinal cord compression, and the need for radiotherapy or surgery for bone metastases, has been the principal endpoint to evaluate bone-targeted therapies for the past 2 decades. (targetedonc.com)
Pathologic fractures, especially in long bones and vertebrae, can result. (medscape.com)
Broken bones (fractures). (nih.gov)
Increasing cases of accidents that leads to bone injury and fractures is again fostering growth of the market. (medgadget.com)
This case describes a unique surgical challenge in a PD patient with multiple cervical fractures, compromised bone quality, and spasmodic torticollis. (hindawi.com)
Although his disease kept Devito confined to a wheelchair and caused him to suffer about 160 fractures over the course of his life, he was a frequent presence at West Point's races. (saratogian.com)

Celiac disease has been associated with compromised bone density in children and adults [ 5 ]. (hindawi.com)
A 28-year-old white male with a history of CF (homozygous for the F508del mutation), CF-related diabetes (CFRD), and pancreatic insufficiency presented for evaluation of low bone density. (hindawi.com)
The patient reported no significant oral or inhaled glucocorticoid use, delayed puberty, tobacco or alcohol use, or other risk factors for low bone density. (hindawi.com)
Vásquez E, Shaw BA, Gensburg L, Okorodudu D, Corsino L. Racial and Ethnic Differences in Physical Activity and Bone Density: National Health and Nutrition Examination Survey, 2007-2008. (cdc.gov)
We obtained data on femoral bone mineral density for 2,819 adults aged 40 to 80 years who self-reported their race/ethnicity on the 2007-2008 National Health and Nutrition Examination Survey. (cdc.gov)
We used linear regression models to examine the association between PA and bone density for each racial/ethnic group. (cdc.gov)
There was a 0.031 g/cm 2 difference in bone density between those in the high PA versus the low PA category ( P = .003). (cdc.gov)
The lack of consistency in bone density differences suggests that the cause of the differences maybe multifactorial. (cdc.gov)
With the expected increase in the US minority population (38.9% in 2012 to 54.0% by 2050) (9,10), the public health importance of understanding racial and ethnic differences in PA and their relation to bone mineral density becomes more relevant. (cdc.gov)
NHANES collects data via household interviews and a physical examination, which includes a bone mineral density test conducted in a mobile examination center. (cdc.gov)
Vitamin D supplements do not help improve bone mineral density in healthy adults, researchers have found. (themedguru.com)
Denosumab effectively treats low bone mineral density in kidney transplant recipients (KTRs), a new study finds. (renalandurologynews.com)
At 1 year after denosumab administration, areal bone mineral density increased by a nonsignificant 1.74% at the lumbar spine and a 0.25% and 0.30% increase at the neck and total femoral site, respectively. (renalandurologynews.com)
Objectives The objectives of this study were to (1) determine the prevalence of low bone mineral density (BMD) in a large prospective cohort of newly diagnosed patients with paediatric systemic lupus erythematosus (pSLE) and (2) identify risk factors associated with low BMD. (bmj.com)
Paediatric studies on bone mineral density (BMD) with rheumatic diseases demonstrated conflicting results. (bmj.com)
Not only is it bio-compatible, its strength, density and porous properties are similar to those of natural bone. (mediaroom.com)
In 22 patients, computerized tomographic scan for bone mineral density (BMD) was performed. (elsevier.com)
In multivariate analysis, smoking status and COPD status were independently associated with bone density, corrected for age and body mass index. (eur.nl)
Based on their results, the researchers concluded the Sema3A that regulates bone density is made by the peripheral nerves. (the-rheumatologist.org)
In this review we discuss about the effects of thyrotoxicosis (endogenous and exogenous) on bone and mineral metabolism, effects of subclinical thyrotoxicosis on bone and mineral metabolism and effects of various forms of treatment in improving the bone mineral density in thyrotoxicosis. (who.int)
Associations between bone mineral density and subclinical peripheral arterial disease in elderly men with type 2 diabetes mellitus. (bvsalud.org)
We demonstrated the association between subclinical PAD and decreased total hip bone mineral density (BMD) in men aged ≥ 55 years with T2DM, providing clinical clues for the early detection of decreased bone density in total hip . (bvsalud.org)
To investigate the association between subclinical peripheral arterial disease (PAD) and bone mineral density (BMD) at total hip , femoral neck , and lumbar spine (L1-4) in elderly men with type 2 diabetes mellitus (T2DM). (bvsalud.org)
Multivariate logistic regression analysis was performed to analyze the contributor for low bone density (T-score (bvsalud.org)
The logistic regression analysis indicated that subclinical PAD was an independent risk factor for the risk of decreased bone density in total hip (adjusted odds ratio [95% CI] 8.933 [1.075-74.222], P = 0.043). (bvsalud.org)
Subclinical PAD (ABI ≤ 0.9) could be used as a risk factor for decreased total hip BMD in men aged ≥ 55 years with T2DM, which provides clinical clues for the early detection of low bone density in total hip in such populations . (bvsalud.org)
A national survey was made of bone mineral density among stunted adolescents and adults. (who.int)
Clinical history, anthropometry and measurement of bone mineral density using dual energy X-ray absorptiometry was done. (who.int)
By the time these changes can be detected by X-rays, as a loss of bone density, significant damage has already occurred," Anbar said. (spaceref.com)
Ultrasound transmission velocity and ultra-sound attenuation of the appendicular skeleton are influenced by bone density and by bone structure and correlated to me-chanical properties of bone. (thieme-connect.de)
Results of the ultrasound techniques and their relation to established radiological measurements for the as-sessment of bone mineral density in vivo and in vitro are reported. (thieme-connect.de)
Caffeine consumption has been studied as a risk factor for many diseases and conditions, including hypertension, bone density, cardiovascular diseases, various cancers, reproduction and developmental abnormalities, and mental and behavioral disorders. (cdc.gov)
It works by causing the body to build new bone and by increasing bone strength and density (thickness). (medlineplus.gov)

Their assessment based on the x-rays is that she has Osteogenesis Imperfecta, more commonly known as Brittle Bone Disease. (gofundme.com)
Brittle Bone disease is a rare genetic disorder that affects human children and other mammals. (gofundme.com)
But the new bone is often weak and brittle. (medicalrecords.com)
These three sisters all have a condition called osteogenesis imperfecta , also known as brittle bone disease. (cure.org)
After being homeschooled due to a medical condition called osteogenesis imperfecta (sometimes known as brittle bone disease), Olive begins attending Macklemore Middle School, where local legend tells of a magical, wish-granting hummingbird. (bookpage.com)
Congie Devito, who worked as the communications director for the successful racing partnership for over a decade, died Feb. 16 of complications from osteogenesis impefecta, also known as brittle bone disease. (saratogian.com)

Overall, these results suggest the potential for long-term cinacalcet therapy to stabilize or slow disease progression, thereby decreasing risk for bone and mineral metabolism disorder and cardiovascular morbidity and mortality. (asnjournals.org)
Vitamin D is a well-known central regulator of bone and calcium metabolism. (termedia.pl)
4 ,5 Animal studies suggest that, in addition to the impact that chronic renal failure has on increasing the likelihood of 1,25(OH)2D3 deficiency and insufficiency caused by the kidney's role in vitamin D metabolism, vitamin D deficiency and insufficiency also have an active role in the progression of kidney disease. (jabfm.org)
He completed an internship in Internal Medicine at William Beaumont Hospital in Royal Oak, Mich. He was Boy Frame Lecturer in Bone and Mineral Metabolism in the Department of Endocrinology at Henry Ford Hospital in Detroit, as well as a Cleveland Clinic Fellow in Nephrology in the Department of Hypertension and Nephrology. (clevelandclinic.org)
Objective: To provide practical recommendations for the management of mineral and bone metabolism alterations in pregnancy and lactation. (bvsalud.org)

As Simplemost reports , The 70-pound sulcata tortoise was born with a metabolic bone disease that halted his leg bones from developing, and he's never been able to walk properly-until now. (mentalfloss.com)
In reptiles, metabolic bone disease can be the result of an imbalance between calcium and phosphorus or from living in a cool environment. (mentalfloss.com)
Metabolic Bone Disease in Reptiles or MBD is one health issue which a reptile pet owner may, unfortunately, have to deal with. (snaketracks.com)
Here, we will help you learn more about metabolic bone disease so you can recognize a potential medical problem right away or better yet, prevent your beloved pet reptile from falling ill to this condition. (snaketracks.com)
Metabolic Bone Disease includes different medical conditions that affect the skeletal system. (snaketracks.com)
Do All Reptiles Suffer from Metabolic Bone Disease? (snaketracks.com)
What Are the Symptoms of Metabolic Bone Disease in Reptiles? (snaketracks.com)
If the temperatures in the reptile enclosure remain uncorrected, serious medical problems like Metabolic Bone Disease may likely occur. (snaketracks.com)
When Captive reptiles do not get, absorb, or synthesize enough dietary calcium, Vitamin D3, and phosphorus, diseases like Metabolic Bone Disease may develop. (snaketracks.com)

SCID is the most severe form of primary immunodeficiency disease (PID), a rare genetic disorder that causes life-threatening problems with the immune system. (gulfnews.com)
This is a pilot study, you are being asked to participate because you have a blood disorder and kidney disease. (centerwatch.com)
The aim of the combined transplant is to treat both your underlying blood disorder and kidney disease. (centerwatch.com)
Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPFD) is a dominant progressive disorder that maps to chromosome 9p21.1-p12. (nih.gov)
Paget's disease of bone is a chronic (long-lasting) disorder that causes bones to grow larger and become weaker than normal. (nih.gov)
Although it is a very rare disorder, study of this and other bone marrow failure syndromes has improved scientific understanding of the mechanisms of normal bone marrow function and development of cancer. (wikipedia.org)
[3] The disease is named after the Swiss pediatrician who originally described this disorder, Guido Fanconi . (wikipedia.org)

Magnesium deficiency in the pathogenesis of disease : early roots of cardiovascular, skeletal, and renal abnormalities / Mildred S. Seelig. (who.int)
Over a mean duration of follow-up of 27 y, the number of observed deaths was 66 632, including 17 957 deaths due to solid cancers, 1791 deaths due to haematological cancers and 27 848 deaths due to cardiovascular diseases. (cdc.gov)
Other benefits of physical activity and exercise include increased cardiovascular fitness, muscle strength, flexibility, energy, and bone mass. (encyclopedia.com)
Diabetic nephropathy is a risk factor for cardiovascular disease and the leading cause of chronic kidney disease in patients starting renal replacement therapy. (jabfm.org)
Dr. Heyka's specialty interests include chronic and acute renal failure, dialysis, hypertension, renal bone disease, cardiovascular disease in kidney patients, and vascular access for dialysis. (clevelandclinic.org)
The ability to obtain molecular information in vivo would help to understand the abnormalities underlying cardiovascular, pulmonary, and blood diseases, would have profound impact on the diagnosis of these conditions, and could provide rapid and efficient assessment of treatment effectiveness. (nih.gov)

we suggest future research aimed to identify the most appropriate clinical contexts where to introduce this treatment in consideration of the complex scenario of bone pathology in patients who have undergone renal transplantation. (renalandurologynews.com)
At Burjeel Medical City, Dr Zainul Aabideen, head of the department of paediatric hematology, oncology and bone marrow transplantation, conducted further evaluations and investigations to ascertain whether she was fit for a bone marrow transplant, the only treatment for this condition. (gulfnews.com)
According to Dr Mansi Suchdev, paediatric bone marrow transplantation consultant at the hospital, there are more than 300 types of PID identified so far. (gulfnews.com)
The only permanent curative treatment for these types of diseases is early diagnosis and bone marrow transplantation (BMT). (gulfnews.com)
Cardiac involvement in mucopolysaccharidoses: effects of allogeneic bone marrow transplantation. (bmj.com)
Echocardiography was performed in 16 children undergoing bone marrow transplantation (BMT) for mucopolysaccharidoses. (bmj.com)
Once considered a difficult and rare surgery, bone marrow transplantation is rated among the greatest success stories in cancer treatment. (manipalhospitals.com)
Mesenchymal stem cell (MSC) transplantation therapy has been proposed as a promising approach for the treatment of neurodegenerative disease. (pasteur.fr)
Our results suggest that preconditioning MSCs with DMOG before transplantation may enhance the efficacy of stem cell based therapy in neurodegenerative disease. (pasteur.fr)
The current scenario is such that there is an increase in the adoption of Bone Marrow Transplantation procedures for treating various chronic diseases. (openpr.com)
This scenario is, by all means, favoring the Bone Marrow Transplantation market growth. (openpr.com)
Furthermore, favorable reimbursement policies are also expected to contribute to the growth of the European Bone Marrow Transplantation Market. (openpr.com)
PMR has presented a comprehensive report based on Bone Marrow Transplantation market as per End User (Hospitals, Multispecialty Clinics, and Ambulatory Surgical Centers), Disease Indication (Leukemia, Lymphoma, Myeloma, and Others), Transplant Type (Autologous Bone Marrow Transplant, and Allogeneic Bone Marrow Transplant) based on seven regions. (openpr.com)
His research programme is aimed at understanding and developing effective therapies for inflammatory neurological diseases, particularly multiple sclerosis (MS). His scientific contributions include studies of T cell repertoires in health and autoimmune disorders, and the elucidation of the mechanisms of action of immuno-modulatory treatments and haematopoietic stem cell transplantation (HSCT) in MS. (imperial.ac.uk)
He has often been invited to present as Speaker to plenary sessions at international scientific meetings in the fields of MS, neuroimmunology and bone marrow transplantation. (imperial.ac.uk)

MADRID - Patients with multiple myeloma regularly receive bisphosphonates to protect their bones against lytic lesions, but a new study suggests that the novel agent denosumab ( Xgeva , Amgen) could be used instead. (medscape.com)
Osteolytic bone disease is highly common in multiple myeloma, with as many as 80% of patients presenting with detectable lesions, while renal disease is also common, presenting in approximately 60%, Dr Terpos explained. (medscape.com)
Bone metastases in breast cancer: higher prevalence of osteosclerotic lesions. (medscape.com)
up to 80% of patients present with osteolytic bone lesions at diagnosis and have an increased risk of skeletal-related events (SREs) associated with increased morbidity and mortality 1 . (nature.com)
Osteonecrosis is a disease that is characterized by lesions of dead bone, most frequently detected in the subchondral bone of the convex side of the major diarthrodial joints (hips, knees, shoulders, and talus). (elsevier.com)
Axonal guidance proteins are also known to "mediate osteoclast-osteoblast interactions in inflammatory bone lesions," Dr. Cronstein added. (the-rheumatologist.org)
Conventional radiography remains the best method to characterize metastatic bone lesions, of which there are three types: osteolytic, sclerotic, and mixed lesions. (medscape.com)
However, instead of destroying bone, these lesions increase cell production, leading to thickened areas of bone. (medscape.com)
For example, the "halo" sign, or "bull's-eye" sign, on MRI helps distinguish bone metastasis from benign lesions. (medscape.com)

We found the bone-specific benefits and observed prolongation of progression-free survival, in combination with a better renal toxicity profile, provide denosumab the potential to be the new standard of care for multiple myeloma-related bone disease," said Evangelos Terpos, MD, from the University of Athens School of Medicine and Alexandra General Hospital, Greece. (medscape.com)

In people with autoimmune diseases, the immune cells attack the body's own healthy tissues by mistake, instead of viruses or bacteria. (nih.gov)

It is linked with renal disease. (snaketracks.com)
Exposing them to very low or high temperatures for an extended period of time may lead to dehydration, renal disease, bladder diseases, and shedding problems. (snaketracks.com)
End-stage renal disease (ESRD) is a major health and economic concern for people all over the world [2]. (termedia.pl)
2 Similarly, the incidence of reported end-stage renal disease in people with diabetes is more than 4 times as high in African Americans and 4 to 6 times as high in Mexican Americans than in the general population of diabetes patients. (jabfm.org)
Chronic kidney disease (CKD) is characterized by an irreversible deterioration of renal function that gradually progresses to end-stage renal disease. (medscape.com)

Physiological bone remodeling is the result of the harmonious coupling of bone resorption and bone formation. (nature.com)
CKD progression in iCTCFpod-/- mice leads to high serum phosphate and elevations in fibroblast growth factor 23 (FGF23) and parathyroid hormone that rapidly cause bone mineralization defects, increased bone resorption, and bone loss. (jci.org)
Objectives: to determine the prevalence of hypovitaminosis D and secondary hyperparathyroidism (SHPT) and to assess bone turnover by using markers of bone formation and resorption in celiac disease (CD). (elsevier.com)
Urinary indices of bone resorption, deoxypyridinoline (DPD), pyridinoline (PyD), and hydroxyproline (OHP), were measured in a 2-h fasting urine. (elsevier.com)
Bone resorption markers were significantly elevated in all groups, and bone formation indices were elevated in the newly diagnosed celiacs compared with a group of healthy adults. (elsevier.com)
Newly diagnosed patients have a high bone turnover state with elevation of both bone formation and resorption indices. (elsevier.com)
Those with refractory disease demonstrate a remodeling imbalance with high bone resorption. (elsevier.com)

Celiac disease may occur at a higher frequency in patients with CF than the general population, and symptoms of these conditions may overlap. (hindawi.com)
The symptoms of celiac disease may be difficult to distinguish from those related to CF, particularly in patients with malabsorption from pancreatic insufficiency. (hindawi.com)
The disease has a wide spectrum of signs and symptoms ( 4 ). (cdc.gov)
Ten days later, high-grade fever up to 40°C developed, without any other signs or symptoms of disease. (cdc.gov)
The mechanisms involved in the development of osteonecrosis [ON] are difficult to explore from clinical samples as they provide a single snapshot at one time point subsequent to the onset of the disease, usually months after the onset of the disease when the symptoms first appear. (elsevier.com)
Most people don't have symptoms, but some have bone pain and deformed or broken bones. (medicalrecords.com)
Ruxolitinib effectively controls the symptoms but does not offer a cure, as the malignant stem cell clone is located in the bone marrow and is generally not attacked. (ehealthweek2010.org)
Symptoms include severe bone pain, bowing of legs, deafness, facial paralysis and spinal deformities. (medindia.net)
Many people with Paget's disease do not have symptoms. (nih.gov)
What Are the Signs & Symptoms of Sickle Cell Disease? (kidshealth.org)
While your symptoms may be typical, like increased thirst and urination, there are also more unusual symptoms of diabetes you may have, like gum disease and hearing changes. (health.com)
So because the unusual diabetes symptoms may be disease warning signs, it is important to know what they are. (health.com)
A growing number of patients, particularly those with advanced, chronic coronary artery disease, experience symptoms of angina that are refractory to treatment with β-blockers, calcium-channel blockers, and long-acting nitrates, despite revascularization. (nature.com)
We will discuss the types of Cushing's disease , its symptoms, and how we diagnose and treat it. (vethelpdirect.com)
Finally, sometimes dogs that are on long-term drugs like prednisolone and dexamethasone (both similar to cortisol) can sometimes show Cushing's-like symptoms if the dose is too high (iatrogenic Cushing's disease). (vethelpdirect.com)
Polydipsia and nocturia (secondary to a reduced capacity to concentrate the urine) may be some of the earliest symptoms that suggest CKD in an otherwise healthy-looking child who has tubulointerstitial kidney disease . (medscape.com)

To have strong bones when you are young, and to prevent bone loss when you are older, you need to get enough calcium , vitamin D , and exercise. (medlineplus.gov)
XLH is caused in part by renal phosphate wasting, which is the urinary loss from the body of phosphate, an important building block of bones and teeth, along with calcium," explains Dr. McKee. (jcda.ca)
Denosumab induces hypocalcemia by reducing osteoclast activity and bone reabsorption with consequent influx of calcium from the circulation into the bone," Dr Manna's team explained. (renalandurologynews.com)
All of these studies have consistently shown that cinacalcet effectively reduces PTH, Ca, P, and calcium-phosphorus product (Ca × P) levels in patients who have stage 5 chronic kidney disease and receive dialysis. (asnjournals.org)
Serum was drawn for intact parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D], ionized calcium (Cai), total alkaline phosphatase (AP), and biochemical markers of bone formation: procollagen I carboxyterminal propeptide (PICP) and osteocalcin (Oc). (elsevier.com)
Since general risk factors and HIV-related factors affect both bone turnover and BMD, the aim of our study was to assess the prevalence of low BMD in HIV-infected subjects and controls and to analyze the effects of calcium intake and other environmental risk factors in order to increase current interest in the management of bone disease in the HIV-population through appropriate dietary and lifestyle interventions. (biomedcentral.com)
Lipton also stressed the importance of proper calcium and vitamin D supplementation, and that while severe events such as ONJ do occur in patients receiving monthly therapy with bone-targeted agents they are comparatively rare. (targetedonc.com)
With the new technique, bone loss is detected by carefully analyzing the isotopes of the chemical element calcium that are naturally present in urine. (spaceref.com)
It is titled "Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes. (spaceref.com)
When bones form, the lighter isotopes of calcium enter bone a little faster than the heavier isotopes. (spaceref.com)
That's similar to what happens with calcium isotopes when bones form. (spaceref.com)
Bone favors lighter calcium isotopes and picks them over the heavier ones. (spaceref.com)
But 15 years ago, corresponding author Joseph Skulan, now an adjunct professor at ASU, combined all the factors into a mathematical model that predicted that calcium isotope ratios in blood and urine should be extremely sensitive to bone mineral balance. (spaceref.com)
But if a disease throws the balance off then you ought to see a shift in the calcium isotope ratios. (spaceref.com)

Getting the right diagnosis can be difficult and many patients with bone marrow failure diseases are often misdiagnosed or diagnosis is delayed. (aamds.org)
An orthopaedic surgeon is a physician who specializes in diagnosis and surgical treatment of injuries and disorders involving the musculoskeletal system, such as hip replacements and arthroscopic knee surgery.In addition to treating trauma to the musculoskeletal system, these doctors also deal with sports injuries, degenerative diseases, infections, tumors and congenital disorders. (vitals.com)
Early diagnosis of this disease is rare. (gulfnews.com)
According to the Nikkeiâ€™s office, every year, at least 20,000 Americans are diagnosed with some form of acquired bone marrow failure disease, and while individuals stricken with these conditions can take some action to prolong their lives, this diagnosis offers little hope that affected patients will ever fully recover. (nichibei.org)
The bill, her office said, would enhance and intensify current and future efforts in the fight against bone marrow failure diseases by supporting increased research on these still relatively unstudied diseases, including what genetic and environmental factors may be associated with the condition and best practices for the diagnosis and treatment of these diseases. (nichibei.org)
The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (medindia.net)
Periapical radiograph can be considered the best radiographic method to evaluate the alveolar bone loss level and, consequently, to help the diagnosis of the periodontal disease. (bvsalud.org)
In some populations, we suspect that possibility of death increases because poor access to health care services might delay diagnosis, resulting in more severe disease. (cdc.gov)
2. Clinical and Histological diagnosis of gastrointestinal Graft-versus-Host Disease from any site in the GI tract. (who.int)

FA is characterized by bone marrow failure, AML , solid tumors, and developmental abnormalities. (wikipedia.org)
In contradistinction to "classical" diagnostic imaging, molecular imaging probes the molecular abnormalities that are the basis of disease rather than imaging the result of these molecular alterations. (nih.gov)
Petrylak said that it does make sense to add another agent to ADT in high-volume disease, given that there are theoretically more genetic abnormalities, more mutations, and a higher chance of drug resistance. (onclive.com)
The doctor can monitor your loved one's vascular disease by ordering periodic ultrasound studies of the leg veins and prescribing medication if blood flow studies reveal abnormalities. (homecareassistancerichmond.com)

However, this pain pattern can be present in patients with osteomyelitis and Paget disease , and in these instances, it is also nonspecific. (medscape.com)
Quality of life after palliative radiation therapy for patients with painful bone metastases: results of an international study validating the EORTC QLQ-BM22. (medscape.com)
We report on two patients presenting with CF-related bone disease in the past year who were subsequently found to have concurrent celiac disease. (hindawi.com)
Because adherence to a gluten-free diet may improve BMD in patients with celiac disease, this could have important implications for treatment. (hindawi.com)
Clinicians should consider screening for celiac disease in patients with CF who have low BMD, worsening BMD in the absence of other risk factors, and/or difficult to treat vitamin D deficiency. (hindawi.com)
As patients with CF live longer, endocrine complications such as CF-related bone disease are becoming increasingly prevalent. (hindawi.com)
Osteolytic bone disease is the hallmark of multiple myeloma, which deteriorates the quality of life of myeloma patients, and it affects dramatically their morbidity and mortality. (nature.com)
Zolendronic acid is combined with novel anti-myeloma agents and reduces SREs, improves quality of life, while it prolongs both disease-free and overall survival at least in subsets of MM patients. (nature.com)
Understanding of the underlying pathogenetic mechanisms of bone destruction is crucial for the effective management and the improvement of quality of life of MM patients. (nature.com)
Thus, the aim of this review is to provide a clear insight into the underlying pathogenesis of bone disease in MM patients. (nature.com)
Recently, less intense chemotherapy and radiation regimens have been employed (these are called reduced intensity regimens) which cause less injury and GVHD to patients, and thus, have allowed older and less healthy patients to undergo bone marrow transplant. (centerwatch.com)
4 Patients with paediatric SLE (pSLE) are at risk of missing this critical period of bone accrual due to disease activity, treatment, decreased physical activity and vitamin D insufficiency. (bmj.com)
5 , - , 8 The confusion in the pSLE literature was partly due to inclusion of patients with varying disease durations and use of varying definitions of 'abnormal' BMD. (bmj.com)
In the United States alone, more than a million patients a year require bone augmentation, experts estimate. (mediaroom.com)
Bone marrow transplants are done to treat patients suffering from leukemia, and severe blood diseases such as thalassemias, aplastic anemia, and sickle cell anemia, as well as multiple myeloma and certain immune deficiency diseases. (manipalhospitals.com)
Bone marrow transplant from a matching donor is done to treat patients with Acute and chronic leukemia, Aplastic anemia, Bone marrow failure syndromes, Hodgkin's lymphoma and Immune deficiencies. (manipalhospitals.com)
Bone marrow transplant patients require maximum care and comfort following the transplant. (manipalhospitals.com)
â€¢Â Agency for Healthcare Research and Quality grants to help improve diagnostic practices and quality of care for patients with bone marrow failure diseases. (nichibei.org)
In patients with inflammatory processes, such as RA or osteoarthritis (OA), the balance between osteoblasts and osteoclasts tips, leading to increased bone loss. (the-rheumatologist.org)
Available options for the treatment of bone metastases in patients with advanced cancers include zoledronic acid, an IV-administered bisphosphonate, and, more recently, denosumab, which is administered as a subcutaneous injection 6,7 and is a monoclonal antibody directed against the receptor activated nuclear factor-κB ligand (RANKL). (targetedonc.com)
As with other solid tumors, patients with advanced prostate cancer are already at risk for bone loss from systemic treatments such as androgen deprivation therapy, and those with bone metastases are at risk for debilitating SREs. (targetedonc.com)
Results from these studies in castration-resistant prostate cancer, 8 advanced breast cancer, 9 and advanced solid tumors (exclusive of breast or prostate) or multiple myeloma 10 demonstrated the efficacy of denosumab over zoledronic acid for preventing SREs in patients with bone metastases. (targetedonc.com)
Changes described in thalassemia major, such as frontal bossing, cortical thinning, dilation of the medullary cavities, prominence of the zygomatic bones, and shortening of the long bones, can also be seen in patients with thalassemia intermedia. (medscape.com)
Then when we developed a half-matched protocol, half of the patients eventually rejected the cells, and the disease came back. (medlineplus.gov)
Bone marrow transplants are not working in 100% of patients. (medlineplus.gov)
To quantify and compare the level of alveolar bone loss on panoramic and periapical radiographs of five (5) patients presenting periodontitis. (bvsalud.org)
On the panoramic and periapical radiographs of five patients, the measurements from the cement-enamel junction (CEJ) to the alveolar bone crest (ABC), at the mesial and distal surfaces of the upper and lower incisors, lower first premolars and first molars, were performed. (bvsalud.org)
In a new study, this technique was more sensitive in detecting bone loss than the X-ray method used today, with less risk to patients. (spaceref.com)
Although it may be unusual for clinicians to encounter newly diagnosed patients with high-grade prostate cancer metastatic to the bone, researchers have noted an increase in patients presenting with high-risk disease since the US Preventive Services Task Force changed its recommendations on prostate cancer screenings, 1 noted Joseph F. Renzulli, II, MD, FACS . (onclive.com)
2 The benefit was more pronounced in patients with high-volume disease. (onclive.com)
Spine surgery in patients with Parkinson's disease (PD) involves increased risk. (hindawi.com)
Recipients will be patients who have had an allogeneic bone marrow transplant and who have steroid dependent (SD) or steroid refractory (SR) Graft-versus-Host Disease. (who.int)

However, the panoramic radiograph is still a valid method for evaluating the level of bone loss caused by the periodontal disease, although the dentist should be aware of the limitation and characteristics of this radiographic technique. (bvsalud.org)
Chronic inflammation is the central feature in the progression of both diabetes and periodontal disease. (health.com)
Periodontal disease can make teeth to loosen or lead to tooth loss. (gilberter.com)
This procedure is not a treatment for active periodontal disease. (gilberter.com)
This treatment for gum disease diminishes the size of the space between the gum and tooth, thereby lowering the zones where harmful bacteria can develop and reducing the opportunity of severe health problems related to periodontal disease. (gilberter.com)

Additionally, it is believed that standard therapy may be associated with a higher risk of a complication called graft versus host disease (GVHD) where the new donor cells attack the recipient's normal body. (centerwatch.com)
Some of the possible complications arising from a bone marrow transplant include graft-versus-host disease, stem cell (graft) failure, organ damage, infections, cataracts, infertility, and new cancers. (manipalhospitals.com)

By the time she had turned nine months old, her parents had consulted infectious diseases experts, who ordered genetic testing based on her history. (gulfnews.com)
This report provides updated uniform criteria * for state health department personnel to use when reporting the nationally notifiable infectious diseases listed in Part 1 of this report. (cdc.gov)
This report supersedes the 1990 report, which included infectious diseases and one noninfectious condition (i.e., spinal cord injury). (cdc.gov)
In times when highly-infectious diseases wiped out entire populations, and the likelihood of catching such a disease was the main medical concern, emphasis on weight gain was normal. (obesityaction.org)
Women generally have more work-related cases of carpal tunnel syndrome, tendonitis, respiratory diseases, infectious diseases, and anxiety and stress disorders. (cdc.gov)

CDC and the Council of State and Territorial Epidemiologists (CSTE) have established a policy that requires state health departments to report cases of selected diseases ( Table 1 ) to CDC's National Notifiable Diseases Surveillance System (NNDSS) (1,2). (cdc.gov)

Typical osteolytic bone metastasis develops in the medullary cavity (marrow cavity) and progresses to not only destroy the cavity but also invade the bony cortex. (medscape.com)

Potentially Therapeutic Levels of Anti-Sickling Globin Gene Expression Following Lentivirus-mediated Gene Transfer in Sickle Cell Disease Bone Marrow CD34(+)Cells. (stembook.org)
Sickle cell disease (SCD) specialists have performed bone marrow transplants in children since the 1990s. (medlineplus.gov)
I'm hoping our research can go beyond sickle cell disease to have a bigger impact. (medlineplus.gov)
We are trying to create a state where instead of completely replacing bone marrow with that of their donors, we are creating a mixture of donor and patient cells because we now know that as low as 20% donor cells is enough to reverse sickle cell disease. (medlineplus.gov)
It's an exciting time for sickle cell disease research. (medlineplus.gov)
The number one disease among newborn babies is sickle cell disease. (medlineplus.gov)
Sickle cell disease is a group of conditions in which red blood cells are not shaped as they should be. (kidshealth.org)
Kids who have sickle cell disease may feel pain in different parts of the body when blood vessels get clogged with sickle cells. (kidshealth.org)
Because kids with sickle cell disease don't have enough normal red blood cells, they may get tired a lot. (kidshealth.org)
Sickle cell disease is an inherited (say: in-HAIR-uh-ted) disease. (kidshealth.org)
How Is Sickle Cell Disease Treated? (kidshealth.org)
Kids with sickle cell disease should get all recommended vaccinations . (kidshealth.org)
Taking medicine does not cure sickle cell disease, but it can help keep kids who have it from getting sick. (kidshealth.org)
Kids with sickle cell disease may need to go to the hospital if they have a lot of pain or a serious infection. (kidshealth.org)
Sometimes kids with sickle cell disease need blood transfusions (say: trans-FEW-zyuns). (kidshealth.org)
In some cases, a bone marrow transplant can cure sickle cell disease. (kidshealth.org)
They are risky and not right for everyone, so scientists are working on finding other ways to cure sickle cell disease. (kidshealth.org)
Having sickle cell disease can be frustrating and sometimes painful. (kidshealth.org)
Those studies can help identify various causes of splenomegaly, such as sickle cell disease, spherocytosis, and other hereditary hemolytic anemias. (medscape.com)

But this most recent injury led to an x-ray consult from the U of M, and now we know that she has actually broken bones in her back legs multiple times. (gofundme.com)

Centers for Disease Control and Prevention. (cdc.gov)
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
If you think you've been exposed to coronavirus (COVID-19), please call the Centers for Disease Control and Prevention at 1-800-232-4636 for further guidance. (msm.edu)
According to the Centers for Disease Control and Prevention (CDC), doing some kind of physical activity or exercise on a regular basis helps to increase strength and flexibility, improve endurance, control weight, increase bone mass, and improve self-esteem, as well as reduce stress, anxiety, depression, and the risk of developing high blood pressure . (encyclopedia.com)
I'm Commander Ibad Khan and I'm representing the Clinician Outreach and Communication Activity, COCA, with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)
Announcer] This program is presented by the Centers for Disease Control and Prevention. (cdc.gov)
Urine samples were processed, stored, and shipped to the Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA for analysis. (cdc.gov)

This award is open to medical doctors who have made significant progress and contribution to the field of bone clinical bone disease research. (helsinki.fi)
BMD was correlated with baseline demographic, clinical and laboratory markers of disease activity and biochemical markers of bone health. (bmj.com)
The clinical use of cinacalcet should bring benefits to the treatment of chronic kidney disease-mineral bone disease, but, at the same time, cinacalcet might increase the medical cost. (asnjournals.org)
The bill would also authorize coordinated outreach and informational programs targeted to minority populations affected by these diseases, including information on treatment options and clinical trials research. (nichibei.org)
SNOWMASS, CO-The go-to medication for treating rheumatoid arthritis (RA)-methotrexate-also has potential for mitigating inflammatory bone disease, according to Bruce Cronstein, MD, Paul R. Esserman professor of medicine, director of NYU-HHC Clinical and Translational Science Institute in New York City, who presented Taking a Bite Out of Inflammatory Bone Disease at the ACR's Winter Rheumatology Symposium this January. (the-rheumatologist.org)
She has participated as a co-investigator in several clinical trials related to Cushings disease. (mountsinai.org)
Eventually, it may find use in clinical settings, and could pave the way for additional innovative biosignatures to detect disease. (spaceref.com)
The clinical features of the disease include frequent visceral and bulky soft-tissue metastases and limited duration of response to both hormonal therapy and cytotoxic chemotherapy. (lww.com)

Kinetic analysis of 18F-fluoride PET images of breast cancer bone metastases. (medscape.com)
Byttner M, Wedin R, Bauer H, Tsagozis P. Outcome of surgical treatment for bone metastases caused by colorectal cancer. (medscape.com)
Bone-targeted agents may help to minimize complications associated with osseous metastases, such as skeletal-related events, but ongoing compliance and adherence to these therapies are important to ensure they provide the desired benefit. (targetedonc.com)
Bone metastases commonly occur with advanced cancers, including cancers of the breast and prostate. (targetedonc.com)
Intravenous (IV) administration, on the other hand, may be combined with monitoring and/or administration of chemotherapy in a single patient visit, and can help ensure ongoing adherence and compliance with bone-targeted therapy for metastases. (targetedonc.com)
Although CT, MRI, and nuclear imaging are useful in monitoring the progression of MBD and a patient's response to treatment, x-ray imaging remains the best method to characterize bone metastases. (medscape.com)
Some men who are initially responsive to potent androgen-deprivation therapy develop gradually progressive disease with bone and lymph node metastases and rising PSA," she said. (lww.com)
But men in this much smaller neuroendocrine group with resistant/refractory disease have rapidly progressive disease with metastases to liver and other abdominal visceral organs, and low PSA. (lww.com)

And inflammatory bowel disease are naturally found in bone tissue and in muscles, and nolvadex (Tamoxifen). (pdxfoodpress.com)

Orthopedic reconstructive surgeons deal with injuries and deformities of your bones and muscles. (vitals.com)
Get the latest scientific news and resources on diseases of the bones, joints, muscles, and skin from the NIAMS. (nih.gov)
Being physically active has also been proven to help build healthy bones, joints, and muscles. (encyclopedia.com)

When necessary, family practitioners will provide referrals for conditions that require the expertise of another specialist.The doctors may also provide physicals, inoculations, prenatal care, treat chronic diseases, like diabetes and asthma, and provide advice on disease prevention. (vitals.com)
They also work to help a patient maintain optimal health in order to prevent the onset of disease.In addition to treating the common cold and flu, internists also treat chronic diseases like diabetes and heart disease. (vitals.com)
She then completed her fellowship training in Endocrinology, Diabetes and Bone diseases at the Icahn School of Medicine at Mount Sinai. (mountsinai.org)
The risk of developing colon cancer, heart disease , high blood pressure , and diabetes is reduced through regular physical activity. (encyclopedia.com)
The gum disease is not only more common, but it's also likely to progress more quickly and be more severe among those with diabetes. (health.com)
The inflammation in diabetes may be a contributing factor as to why the bones that support your teeth are destroyed. (health.com)
Peripheral vascular disease is more common in older adults and people with diabetes. (homecareassistancerichmond.com)

Heavy monsoon rain is associated with severe disease course ( 2 ). (cdc.gov)
Months after her birth, Eman was diagnosed with severe combined immunodeficiency disease (SCID), an extremely uncommon genetic condition that leaves infants susceptible to severe infections right from the time they are born. (gulfnews.com)
The most common feature of SCID disease is recurrent severe infections from birth. (gulfnews.com)
Of note, RANKL antibodies can be used to inhibit bone turnover and treat very severe forms of OA, Dr. Cronstein said. (the-rheumatologist.org)
Even for those who ultimately survive the disease, if not treated immediately, it takes mere days for them to be left with severe facial disfigurements that make it hard to eat, speak, see or breathe. (who.int)
Gum disease, also called periodontitis , is a severe form of gum infection that harms the soft tissue and, if left untreated, it can ruin the bone that holds your teeth. (gilberter.com)
Shira Shafir] We know that people with compromised or suppressed immune systems are more likely to get severe disease because their immune systems are not able to control the infection and this allows the fungus to spread from the lungs to other organs. (cdc.gov)
Shira Shafir] While coccidioidomycosis has the potential to be severe and fatal, we believe that the number of deaths in the US associated with this disease are limited. (cdc.gov)
Shira Shafir] When we see more people die in some groups as compared to others, we think it's either because certain groups are at an increased risk of exposure, they might have an increased risk of severe disease, or a combination of these two factors. (cdc.gov)
Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn. (medscimonit.com)

Targeted therapies, based on the better knowledge of the biology, constitute a promising approach in the management of myeloma-related bone disease and several novel agents are currently under investigation. (nature.com)
The therapeutic strategy of MM-induced bone disease includes a multimodality approach ranging from bisphosphonates and targeted therapies to local irradiation and orthopedic intervention 1 . (nature.com)

Celiac disease is an autoimmune disease of the small intestine caused by sensitivity to dietary gluten resulting in intestinal malabsorption. (hindawi.com)
Screening for celiac disease typically entails serologic testing of celiac-specific antibodies followed by pathologic confirmation with duodenal mucosal biopsy [ 4 ]. (hindawi.com)
We report two cases of young adults who presented to our CF Center Endocrine Clinic in the past year with CF-related bone disease and upon further evaluation were subsequently diagnosed with concurrent celiac disease. (hindawi.com)
Pertinent family history included an aunt with celiac disease. (hindawi.com)
Screening tests for celiac disease showed a total immunoglobulin A (IgA) of 375 ng/dL (reference range 69-309 mg/dL) and an elevated anti-tissue transglutaminase (TTG) IgA level of 195.09 U/mL (reference range 0-15 U/mL). (hindawi.com)
He underwent endoscopy with duodenal biopsies, and pathology revealed villous blunting with intraepithelial lymphocytosis consistent with celiac disease. (hindawi.com)
While there have been two case reports, it remains doubtful whether a bone marrow transplant from a person with celiac disease to a person who does not have it can led to the development of the disease, as in both cases the recipients already had the predisposing genes. (cureceliacdisease.org)
Can someone with celiac disease donate blood, bone marrow or organs? (cureceliacdisease.org)
There is no reason why someone with celiac disease (in remission while on a gluten-free diet) can't donate blood, other biological specimens or postmortem organs. (cureceliacdisease.org)

Both biochemical bone turnover markers and BMD, assessed by dual-energy radiographic absorptiometry (DXA) were recorded in the HIV-cases and controls. (biomedcentral.com)

When the mean values of the alveolar bone loss were compared between panoramic and periapical radiograph, it was verified that the panoramic radiograph measurements were 0.93 mm higher than periapical radiograph values. (bvsalud.org)

Today we will be discussing a relatively common disease of the endocrine system called Cushing's disease. (vethelpdirect.com)

Job stress has been linked with heart disease, muscle/bone disorders, depression, and burnout. (cdc.gov)
The aim of this paper is to review the literature and identify orofacial manifestations of hematological diseases, with particular reference to anemias and disorders of hemostasis. (ijdr.in)
Orofacial petechiae, conjunctivae hemorrhage, nose-bleeding, spontaneous and post-traumatic gingival hemorrhage and prolonged post-extraction bleeding are common orofacial manifestations of inherited hemostatic disorders such as von Willebrand's disease and hemophilia. (ijdr.in)
orofacial diseases AND anaemic disorders. (ijdr.in)
Neurological disorders such as Parkinson's disease can also cause mobility limitations in seniors. (homecareassistancerichmond.com)
Definition of neurology: a science involved in the study of the nervous systems, especially of the diseases and disorders affecting them. (neurosciencenews.com)

Identification of VCP as causing IBMPFD has important implications for other inclusion-body diseases, including myopathies, dementias and Paget disease of bone (PDB), as it may define a new common pathological ubiquitin-based pathway. (nih.gov)

The results of the research, which received funding from CIHR and FAPESP (Brazil), are published in the March 2013 issue of the Journal of Bone and Mineral Research . (jcda.ca)
Journal of Bone and Mineral Research. (mayo.edu)
Journal of Bone and Mineral Research , 29 (10), 2224-2229. (eur.nl)

Although the cause is not entirely clear, pulmonary hypertension likely develops from longstanding chronic anemia, hypoxia, iron overload, and microthrombotic disease of the pulmonary circulation. (medscape.com)

Unlike bisphosphonates, such as zoledronic acid - which is the most common treatment for bone disease in multiple myeloma - denosumab can be administered subcutaneously. (medscape.com)
Melody needs orthopedic surgery to help mend this fracture, and she will need life-long treatment to help her bones get stronger, although I'm not certain human-developed medications for this disease can be tolerated by cats. (gofundme.com)
Rather than focusing on the treatment of one disease or patient population, family practitioners are often the doctors that people see for their everyday ailments, like cold and flu or respiratory infections, and health screenings. (vitals.com)
Traditionally, very strong cancer treatment drugs (chemotherapy) and radiation are used to prepare a subject's body for bone marrow transplant. (centerwatch.com)
9 , - , 13 Furthermore, the relative importance of disease activity and treatment was hard to determine as the studies were cross-sectional. (bmj.com)
Manipal Hospital has the most advanced cancer care and treatment facilities to perform the most complex bone marrow transplants. (manipalhospitals.com)
Because of this link, Dr. Cronstein said, axonal guidance proteins may be novel targets for the treatment of bone disease. (the-rheumatologist.org)
Treatment of thyrotoxicosis leads to reversal of bone loss and metabolic alterations, and decreases the fracture risk. (who.int)
Treatment with androgens and hematopoietic (blood cell) growth factors can help bone marrow failure temporarily, but the long-term treatment is bone marrow transplant if a donor is available. (wikipedia.org)
With the introduction of new highly potent androgen receptor-targeted agents into the clinic, such as abiraterone acetate, treatment-related neuroendocrine prostate cancer is becoming an even more important disease to recognize. (lww.com)
Brushing twice a day, flossing each day and getting regular dental checkups can significantly enhance your odds of successful treatment for gum disease. (gilberter.com)
Your dentist performs this treatment for gum disease under a local anesthetic. (gilberter.com)
In case the nonsurgical treatment for gum disease is not successful, you can have surgical option. (gilberter.com)
Your dentist completes this treatment in blend with flap surgery, he will insert a little bit of mesh-like material between the bone and gum tissue. (gilberter.com)
This treatment preserves the gum tissue from developing into the territory where the bone should be, permitting the bone and connective tissue to regrow to more readily uphold the teeth. (gilberter.com)

Childhood and adolescence are crucial periods of bone mass accrual. (bmj.com)
Further, Dr. Cronstein said, research has shown that Sema3A regulates bone mass accrual through sensory innervations. (the-rheumatologist.org)

Metastatic bone disease: a guide to good practice (2015 revision). (medscape.com)

Problems in the joints near the bones with the disease. (nih.gov)

This is associated with a high risk for serious complications, even in subjects without kidney disease. (centerwatch.com)
A trusted dental practice in Gordon, NSW , will help treat your gum disease and other dental complications. (gilberter.com)

MPNs are a group of rare, malignant diseases of the bone marrow involving the production of an excess of red blood cells, white blood cells and/or platelets. (ehealthweek2010.org)

Depending on the apparent etiology, bone marrow biopsy may be needed. (medscape.com)
Men rarely undergo biopsy of their tumors once those tumors have spread to bone or soft tissue regions of the body, Beltran noted. (lww.com)

ACS encompass a spectrum of unstable coronary artery disease. (e-booksdirectory.com)

Our transplant surgeons are the best in their league to diagnose and stage the perfect bone marrow therapy for both benign and malignant cancers. (manipalhospitals.com)
Analyses demonstrated a significant association between red bone marrow dose and the risk of leukaemia (excluding chronic lymphocytic leukaemia) and between colon dose and the risk of solid cancers. (cdc.gov)
Bone loss also occurs in a number of cancers in their advanced stages. (spaceref.com)

The spleen, greatly enlarged by the disease, shrinks back to its normal size and the progression of the disease is delayed. (ehealthweek2010.org)
And while it rarely arises de novo, the amount of neuroendocrine differentiation of prostate adenocarcinoma increases with disease progression and in response to androgen-deprivation therapy. (lww.com)

The main purpose of this study is to examine the outcome of a combined bone marrow and kidney transplant from a partially matched related (haploidentical or "haplo") donor. (centerwatch.com)
Additionally, because the same person who is donating the kidney will also be donating the bone marrow, there may be a smaller chance of kidney rejection and less need for long-term use of anti-rejection drugs. (centerwatch.com)
One goal in our study is to decrease the duration you will need to be on immunosuppressant drugs following your kidney transplant as the bone marrow transplant will provide you with the donor's immune system which should not attack the donor kidney. (centerwatch.com)
Progressive chronic kidney diseases (CKDs) are on the rise worldwide. (jci.org)
Podocyte-specific CTCF deletion in adult mice leads to nephrotic syndrome, podocyte loss, progressive kidney disease, and death. (jci.org)
Chronic kidney disease (CKD) has emerged as a major public health issue in recent years [1]. (termedia.pl)
and liver, kidney, or heart disease. (medlineplus.gov)
Chronic kidney disease (CKD) and renal failure (RF) have been recognized as significant medical problems for most of the last 2 centuries and, until relatively recently, were uniformly fatal. (medscape.com)
Chronic kidney disease has emerged as a serious public health problem. (medscape.com)
[ 1 ] Moreover, in the past 2 decades, the incidence of chronic kidney disease in children has steadily increased, with poor and ethnic minority children disproportionately affected. (medscape.com)

MPNs are chronic diseases with only 1 to 2 new cases diagnosed per 100,000 people every year. (ehealthweek2010.org)
The CDC Surveillance Coordination Group has established a steering committee that is charged with the development of a broad range of case definitions for noninfectious conditions (e.g., environmental or occupational conditions, chronic diseases, adverse reproductive health events, and injuries). (cdc.gov)

Axial nonenhanced computed tomography showing moth-eaten appearance of right parietal bone characteristic of osteomyelitis. (cdc.gov)
Computed tomography of the scalp was performed ( Figure ), and osteomyelitis of the right parietal bone was detected. (cdc.gov)
The authors report a rare case of acute osteomyelitis of the scaphoid bone in the left wrist, due to Staphylococcus aureus, in a 53 year-old paraplegic man without an apparent initial cause. (scielo.br)

Anatomy29

Organisms3

Diseases60

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Psychiatry and Psychology1

Phenomena and Processes13

Disciplines and Occupations1

Technology, Industry, Agriculture2

Health Care2

Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions: a randomized, placebo-controlled trial. Protocol 18 Aredia Breast Cancer Study Group. (1/1036)

The aetiology of congenital angulation of tubular bones with constriction of the medullary canal, and its relationship to congenital pseudarthrosis. (2/1036)

Massive pelvic and femoral pseudotumoral osteolysis secondary to an uncemented total hip arthroplasty. (3/1036)

Circulating biochemical markers of bone remodeling in uremic patients. (4/1036)

Cladribine activity in adult langerhans-cell histiocytosis. (5/1036)

Osteoblast-specific gene expression after transplantation of marrow cells: implications for skeletal gene therapy. (6/1036)

Beta2-microglobulin and renal bone disease. (7/1036)

Prostaglandins and bone: physiology and pathophysiology. (8/1036)

Bone Diseases

Bone and Bones

Bone Diseases, Metabolic

Bone Remodeling

Bone Resorption

Bone Density

Renal Osteodystrophy

Bone Neoplasms

Osteomalacia

Diphosphonates

Bone Marrow

Osteolysis

Osteoclasts

Bone Development

Bone Marrow Cells

Multiple Myeloma

Osteitis Fibrosa Cystica

Osteoblasts

Parathyroid Hormone

Osteoporosis

Alkaline Phosphatase

Fractures, Bone

Bone Matrix

Osteitis Deformans

Osteolysis, Essential

Osteogenesis

Aluminum

RANK Ligand

Bone Regeneration

Ilium

Bone Density Conservation Agents

Hyperparathyroidism

Osteoprotegerin

Dihydrotachysterol

Hyperparathyroidism, Secondary

Bone Marrow Transplantation

Fractures, Spontaneous

Bone Transplantation

Osteocalcin

Osteocytes

Bone Diseases, Endocrine

Phosphorus

Rickets

Bone Morphogenetic Proteins

Bone Substitutes

Hypercalcemia

Strontium Isotopes

Femur

Osteonecrosis

Technetium Tc 99m Medronate

Clodronic Acid

Fibrous Dysplasia of Bone

Osteopetrosis

Calcification, Physiologic

Receptor Activator of Nuclear Factor-kappa B

Tibia

Absorptiometry, Photon

Etidronic Acid

Renal Dialysis

Calcium Metabolism Disorders

Bone Morphogenetic Protein 2

Minerals

Kidney Failure, Chronic

Pelvic Bones

Potassium Citrate

Osteosclerosis

Temporal Bone

Hydroxycholecalciferols

Cell Differentiation

Calcium

Uremia

Vitamin D

Jaw Diseases

Collagen Type I

X-Ray Microtomography

Skull

Parietal Bone

Bone Diseases, Infectious

Osteogenesis Imperfecta

Technetium Compounds