Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Mechanical food dispensing machines.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
The profession of writing. Also the identity of the writer as the creator of a literary production.
A publication issued at stated, more or less regular, intervals.
The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.
An intraductal carcinoma of the breast extending to involve the nipple and areola, characterized clinically by eczema-like inflammatory skin changes and histologically by infiltration of the dermis by malignant cells (Paget's cells). (Dorland, 27th ed)
A rare cutaneous neoplasm that occurs in the elderly. It develops more frequently in women and predominantly involves apocrine gland-bearing areas, especially the vulva, scrotum, and perianal areas. The lesions develop as erythematous scaly patches that progress to crusted, pruritic, erythematous plaques. The clinical differential diagnosis includes squamous cell carcinoma in situ and superficial fungal infection. It is generally thought to be an adenocarcinoma of the epidermis, from which it extends into the contiguous epithelium of hair follicles and eccrine sweat ducts. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1478)
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Inflammation of the bone.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Diseases of BONES.
Course of conduct directed at a specific person that involves repeated (two or more occasions) visual or physical proximity, nonconsensual communication, or verbal, written, or implied threats, or a combination thereof, that would cause a reasonable person fear.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES).
COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.
Breaks in bones.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.
Individual's rights to obtain and use information collected or generated by others.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
Persons who provide care to those who need supervision or assistance in illness or disability. They may provide the care in the home, in a hospital, or in an institution. Although caregivers include trained medical, nursing, and other health personnel, the concept also refers to parents, spouses, or other family members, friends, members of the clergy, teachers, social workers, fellow patients.
Tumors or cancer of the VULVA.
Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.
Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.
Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Dissolution of bone that particularly involves the removal or loss of calcium.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
The hollow, muscular organ that maintains the circulation of the blood.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Pressure, burning, or numbness in the chest.
A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing pain.
Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
Bone loss due to osteoclastic activity.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.

Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions: a randomized, placebo-controlled trial. Protocol 18 Aredia Breast Cancer Study Group. (1/1036)

PURPOSE: To assess whether pamidronate can reduce the frequency of skeletal morbidity in women with lytic bone metastases from breast cancer treated with hormone therapy. PATIENTS AND METHODS: Three hundred seventy-two women with breast cancer who had at least one lytic bone lesion and who were receiving hormonal therapy were randomized to receive 90 mg of pamidronate or placebo as a 2-hour intravenous infusion given in double-blind fashion every 4 weeks for 24 cycles. Patients were evaluated for skeletal complications: pathologic fractures, spinal cord compression, irradiation of or surgery on bone, or hypercalcemia. The skeletal morbidity rate (the ratio of the number of skeletal complications to the time on trial) was the primary efficacy variable. Bone pain, use of analgesics, quality of life, performance status, bone tumor response, and biochemical parameters were also evaluated. RESULTS: One hundred eighty-two patients who received pamidronate and 189 who received placebo were assessable. The skeletal morbidity rate was significantly reduced at 12, 18, and 24 cycles in patients treated with 90 mg of pamidronate (P = .028, .023, and .008, respectively). At 24 cycles, the proportion of patients having had any skeletal complication was 56% in the pamidronate group and 67% in the placebo group (P = .027). The time to the first skeletal complication was longer for patients receiving pamidronate than for those given placebo (P = .049). There was no statistical difference in survival or in objective bone response rate. Pamidronate was well tolerated. CONCLUSION: Treatment with 90 mg of pamidronate as a 2-hour intravenous infusion every 4 weeks in addition to hormonal therapy significantly reduces skeletal morbidity from osteolytic metastases.  (+info)

The aetiology of congenital angulation of tubular bones with constriction of the medullary canal, and its relationship to congenital pseudarthrosis. (2/1036)

It is suggested that there is a group of cases of congenital angulation of tubular bones in which the lesion is a defect of ossification of the primary cartilaginous anlage and in which neurofibromatosis is not implicated. It appears that in this group the prognosis with regard to the resolution of deformity and the prevention of pseudarthrosis with conservative treatment or relatively simple surgical procedures is better than that in the neurofibromatous type.  (+info)

Massive pelvic and femoral pseudotumoral osteolysis secondary to an uncemented total hip arthroplasty. (3/1036)

A 51 year-old man developed an extensive osteolytic response to wear debris in an uncemented porous-coated total hip arthroplasty, with metal/polyethylene interface, which had been implanted eighteen years previously. This reaction, which involved the upper femur and the ilium, produced a mass which compressed the pelvic viscera.  (+info)

Circulating biochemical markers of bone remodeling in uremic patients. (4/1036)

Chronic renal failure is often associated with bone disorders, including secondary hyperparathyroidism, aluminum-related low-turnover bone disease, osteomalacia, adynamic osteopathy, osteoporosis, and skeletal beta2-microglobulin amyloid deposits. In spite of the enormous progress made during the last few years in the search of noninvasive methods to assess bone metabolism, the distinction between high- and low-turnover bone diseases in these patients still frequently requires invasive and/or costly procedures such as bone biopsy after double tetracycline labeling, scintigraphic-scan studies, computed tomography, and densitometry. This review is focused on the diagnostic value of several new serum markers of bone metabolism, including bone-specific alkaline phosphatase (bAP), procollagen type I carboxy-terminal extension peptide (PICP), procollagen type I cross-linked carboxy-terminal telopeptide (ICTP), pyridinoline (PYD), osteocalcin, and tartrate-resistant acid phosphatase (TRAP) in patients with chronic renal failure. Most of the observations made by several groups converge to the conclusion that serum bAP is the most sensitive and specific marker to evaluate the degree of bone remodeling in uremic patients. Nonetheless, PYD and osteocalcin, in spite of their retention and accumulation in the serum of renal insufficient patients, are also excellent markers of bone turnover. The future generalized use of these markers, individually or in combination with other methods, will undoubtedly improve the diagnosis and the treatment of the complex renal osteodystrophy.  (+info)

Cladribine activity in adult langerhans-cell histiocytosis. (5/1036)

Langerhans-cell histiocytosis (LCH) results from the accumulation of tissue histiocytes derived from the same progenitor cells as monocytes. Because cladribine is potently toxic to monocytes, we conducted a phase II trial of cladribine. Cladribine was administered to 13 LCH patients at 0.14 mg/kg per day by 2-hour intravenous infusion for 5 consecutive days, every 4 weeks for a maximum of six courses. Median age was 42 years (range, 19 to 72) and median pretreatment disease duration was 99 months (range, 6 to 252). One patient was untreated, one had received prior prednisone only, one prior radiation only, six prior radiation and chemotherapy, and four prior surgery, radiation, and chemotherapy. Seven patients had cutaneous involvement, six multifocal osseous, six pulmonary, two each with soft tissue and nodal involvement, and four had diabetes insipidus. Of 13 patients, 12 were evaluable for response and all for toxicity. After a median of three courses (range, 1 to 6), seven (58%) patients achieved complete responses (two pathologic and five clinical) and two (17%) patients achieved partial responses; overall response rate, 75%. Median response follow-up duration was 33 months (range, 1 to 65). Seven patients experienced grade 3 to 4 neutropenia. Only one patient had a documented infection, dermatomal herpes zoster. At a median follow-up of 42 months (range, 5 to 76), 12 patients remain alive and one patient has died. Thus, cladribine has major activity in adult LCH and warrants further investigation in both pediatric and adult LCH as a single agent and in combination with other drugs.  (+info)

Osteoblast-specific gene expression after transplantation of marrow cells: implications for skeletal gene therapy. (6/1036)

Somatic gene therapies require targeted transfer of the therapeutic gene(s) into stem cells that proliferate and then differentiate and express the gene in a tissue-restricted manner. We have developed an approach for gene therapy using marrow cells that takes advantage of the osteoblast specificity of the osteocalcin promoter to confine expression of chimeric genes to bone. Adherent marrow cells, carrying a reporter gene [chloramphenicol acetyltransferase (CAT)] under the control of a 1.7-kilobase rat osteocalcin gene promoter, were expanded ex vivo. After transplantation by intravenous infusion, engrafted donor cells in recipient mice were detected by the presence of the transgene in a broad spectrum of tissues. However, expression of the transgene was restricted to osteoblasts and osteocytes, as established by biochemical analysis of CAT activity and immunohistochemical analysis of CAT expression at the single cell level. Our data indicate that donor cells achieved long-term engraftment in various tissues of the recipients and that the CAT gene under control of the osteocalcin promoter is expressed specifically in bone. Thus, transplantation of multipotential marrow cells containing the osteocalcin promoter-controlled transgene provides an efficacious approach to deliver therapeutic gene expression to osteoblasts for treatment of bone disorders or tumor metastasis to the skeleton.  (+info)

Beta2-microglobulin and renal bone disease. (7/1036)

Dialysis-related amyloidosis (DRA) is characterized by amyloid deposition mainly in bone and joint structures, presenting as carpal tunnel syndrome, destructive arthropathy, and subchondral bone erosions and cysts. Beta2-microglobulin has been demonstrated to be a major constituent of amyloid fibrils. DRA occurs not only in patients undergoing long-term hemodialysis, but also in patients undergoing continuous ambulatory peritoneal dialysis. The incidence of this complication increases with the duration of dialytic therapy and the age of the patient. While a definitive diagnosis of DRA can be made only by histological findings, various imaging techniques often support diagnosis. The molecular pathogenesis of this complication remains unknown. Recent studies have, however, suggested a pathogenic role of a new modification of beta2-microglobulin in amyloid fibrils--that is, the advanced glycation end-products (AGEs) formed with carbonyl compounds derived from autoxidation of both carbohydrates and lipids ("carbonyl stress"). Therapy for DRA is limited to symptomatic approaches and surgical removal of amyloid deposits. High-flux biocompatible dialysis membranes could be used to delay DRA development.  (+info)

Prostaglandins and bone: physiology and pathophysiology. (8/1036)

Prostaglandins (PGs) are potent stimulators of bone formation and resorption and are produced by bone cells. PGs also have inhibitory effects on fully differentiated osteoblasts and osteoclasts. This complex, multifunctional regulation is probably mediated by different PG receptors. Endogenous PGs in bone are produced largely by induction of COX-2, which is highly regulated by hormones and local factors. The development of specific agonists and antagonists for PG receptors and for COX-2 should allow us to define the physiologic and pathophysiologic roles of PGs more precisely and develop new therapeutic approaches to metabolic and inflammatory disorders of the skeleton.  (+info)

Treatment of Myeloma Bone Disease James R. Berenson, MD Medical & Scientific Director Institute for Bone Cancer & Myeloma Research West Hollywood, CA Clinical Consequences of Myeloma Bone Disease Pathological
Bone disease: Bone disease, any of the diseases or injuries that affect human bones. Diseases and injuries of bones are major causes of abnormalities of the human skeletal system. Although physical injury, causing fracture, dominates over disease, fracture is but one of several common causes of bone disease, and
Bone Diseases Essay, Research Paper Bone diseases most directly influence the ability to walk or to move any part of the body-hands, limbs, neck, and spine. They are
This study will look to see if there are changes in the blood cells that are associated with bone disease and sort out effects that are due to the HIV virus itself, the medications and see if faster aging occurs in the cells of HIV infected persons. Bone disease will be measured by a special X-ray called a DEXA scan. A DEXA scan is used by doctors to see if someone has normal bone mass for their age or if there is thinning of the bones.. The purposes of this study are:. ...
HD Bone Diseases App is simply a source of information about the human musculoskeletal system and some of its diseases/conditions. The facts are well presented in clear sections with eye-catching pictures and pitched at a level which most will find easy to follow. A number of historical facts about conditions are included which makes interesting reading. There is an excellent section on osteoporosis, explaining the cause, investigations and treatments. The other two sections focus on certain bone diseases - these are explained well with lots of detailed information, but the list of conditions covered is far from comprehensive ...
Gum & Bone Disease - Gum and bone disease, otherwise known as periodontal disease, affects over 60 million American adults to some degree every year. Shiley H. Bien, DMD, and
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Journal of Osteoporosis is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working on the diagnosis, prevention, treatment and management of osteoporosis and other metabolic bone diseases. The journal publishes research articles, review articles, as well as clinical studies related to the biology, physiology, and pathology of bone and muscle.
What is bone disease and how does it develop in children? Childhood and adolescence are crucial years for the accrual of minerals necessary for bone health. Appropriate accumulation of these minerals (calcium, phosphorous and magnesium) in the bone help the body reach an optimal peak bone mass in young adulthood and decrease the likelihood of osteoporosis in old age.
So change your daily routine before you have to look for the best orthopedic hospitals in Mumbai.. Injuries: Dont neglect your joint or bone injuries. You may accidentally hurt your knees or joints or otherwise. But even after applying pain relieving cream or ice pack over the area if the pain sustains, then dont waste much time but consult an orthopedic doctor right away.. Diet: Fast food is a big no no if you want to stay healthy in every possible means. You have to have a very healthy and heavy protein rich breakfast. Green leafy vegetables, fish, meat and eggs should be there in your diet. Pulses and nuts should be there as well. Bone diseases are caused due to calcium deficiency. So try to have protein enriched food.. What to do next: If you are having pain in your joints or any bone related problems then do look for orthopedic doctors in the town. Take the help of the internet and research about the doctors and the hospitals they are associated with. In doing so dont stick to one ...
Osteoporosis bone disease literally means bones with holes. It occurs when bones lose minerals such as calcium more quickly than the body can replace them
What is bone disease? Why do people with HIV appear to be especially at risk? What are the signs you might be developing bone problems? In this new ...
Dogs of all ages can limp for a variety of reasons, one being bone disease. With a variety of causes and symptoms, usually associated with appearing sore and tired, it is best to contact your veterinarian for treatment options.
Pathogenesis of Bone Diseases: The Role of Immune System. . Download books free in pdf. Online library with books, university works and thousands of documents available to read online and download.
Learn about the veterinary topic of Noninfectious Skeletal Disorders in Broilers. Find specific details on this topic and related topics from the Merck Vet Manual.
This is your stop for learning resources, extra info and essential dates and documents. Ive scoured the world just to bring you, the A Level biologists, all you need to succeed and enjoy your Biology A Level.
Poor nutrition at any point in a dogs life can lead to chronic conditions like obesity, skeletal diseases and even a shorter life span. In the video
Multiple myeloma is a hematologic malignancy associated with the development of a destructive osteolytic bone disease. Mathematical models are developed for normal bone remodeling and for the dysregulated bone remodeling that occurs in myeloma bone disease. The models examine the critical signaling between osteoclasts (bone resorption) and osteoblasts (bone formation). The interactions of osteoclasts and osteoblasts are modeled as a system of differential equations for these cell populations, which exhibit stable oscillations in the normal case and unstable oscillations in the myeloma case. In the case of untreated myeloma, osteoclasts increase and osteoblasts decrease, with net bone loss as the tumor grows. The therapeutic effects of targeting both myeloma cells and cells of the bone marrow microenvironment on these dynamics are examined. The current model accurately reflects myeloma bone disease and illustrates how treatment approaches may be investigated using such computational approaches. This
The fellowship in Metabolic Bone Disease is a 1 year clinical research program. Successful completion of the program will enable the fellow to evaluate , diagnose and provide evidence based management of complex metabolic bone diseases. These include osteoporosis in pre and postmenopausal women as well as in men, fibrous dysplasia, sclerotic bone diseases, osteomalacia, osteogenesis imperfecta, hypophosphatasia, X-linked hypophosphatemia , renal osteodystrophy and pagets disease. The fellow will also gain competence in evaluating complex calcium and parathyroid disorders as well as an understanding of how and when to complete genetic testing for calcium disorders as well as metabolic bone diseases. The fellow will attend the American Society of Bone and Mineral Research annual scientific meeting and submit research for presentation at this meeting . The fellowship curriculum is outlined in the American Society of Bone and Mineral Research Primer. It is expected that the fellow will be gain this ...
Looking for online definition of uremic bone disease in the Medical Dictionary? uremic bone disease explanation free. What is uremic bone disease? Meaning of uremic bone disease medical term. What does uremic bone disease mean?
Bone disease - Metabolic bone disease: The normal function of bone requires an adequate supply of amino acids (the building blocks for proteins) for the synthesis of collagen, the chief component of the organic matrix; of calcium and phosphate for mineralization of the organic matrix; and of other organic compounds and mineral elements. Also, growth, repair, and remodeling of the bone tissue require a precisely regulated supply of hormones, vitamins, and enzymes. Skeletal disease, when it is due to inadequacies in the supply or action of the above essentials, associated with abnormalities outside the skeleton, is termed metabolic; in such cases the entire skeleton is affected.
TY - JOUR. T1 - A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma. AU - Noonan, Kimberly. AU - Marchionni, Luigi. AU - Anderson, Judy. AU - Pardoll, Drew. AU - Roodman, G. David. AU - Borrello, Ivan. PY - 2010/11/4. Y1 - 2010/11/4. N2 - Osteoclast (OC)-mediated lytic bone disease remains a cause of major morbidity in multiple myeloma. Here we demonstrate the critical role of interleukin-17-producing marrow infiltrating lymphocytes (MILs) in OC activation and development of bone lesions in myeloma patients. Unlike MILs from normal bone marrow, myeloma MILs possess few regulatory T cells (Tregs) and demonstrate an interleukin-17 phenotype that enhances OC activation. In univariate analyses of factors mediating bone destruction, levels of cytokines that selectively induce and maintain the Th17 phenotype tightly correlated with the extent of bone disease in myeloma. In contrast, MILs activated under conditions that skew toward a Th1 phenotype ...
The Metabolic Bone Diseases Clinic at Tufts Medical Center in Boston provides care to manage increased risk for fragility fractures due to bone diseases, like osteoporosis.
The Lawrence Research Competition was established in 2006 to provide seed grants of $45,000 each to two promising investigators in metabolic or metastatic bone disease. Eligible projects include those that study bone metastases, bone health in cancer patients, bone formation, and bone biology. Through mechanisms such as the Rolanette and Berdon Lawrence Bone Research Awards, the Bone Disease Program reaffirms its commitment to fostering groundbreaking research and supporting talented, young investigators in bone research careers ...
ASBMR (2008) Chapter 42. Genetics of Osteoporosis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470623992.ch42 ...
ASBMR (2008) Chapter 9. Animal Models: Allelic Determinants for BMD, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470623992.ch9 ...
Osteoporosis and other bone diseases, such as Pagets disease and osteogenesis imperfecta, can lead to a downward spiral in physical health and quality of life including losing the ability to walk, stand, and dress. It can even lead to premature death. Weak bones can result in painful and debilitating fractures. Each year, 1.5 million Americans suffer a fracture because of weak bones. The most common breaks are of the wrist, spine and hip.. Hip fractures are by far the most devastating type of broken bone and account for almost 300,000 hospitalizations each year. Of hip-fracture patients: 20 percent die within a year of the fracture, and 20 percent end up in a nursing home within a year. Many become isolated, depressed or afraid to leave home because they fear falling.. Bone disease is costly for society and individuals with the disease. In the United States, care for bone fractures from osteoporosis costs nearly $18 billion each year. The cost from a hip fracture for one individual can be more ...
In recent years there has been an increase in the diagnosis of Metabolic Bone disease in hedgehogs and it is a life-threatening syndrome. While the
This finding brings up important questions for further research, said Dr. Brendan Lee, professor of molecular and human genetics at BCM and corresponding author of the report. What happens if you make higher levels of the protein associated with WNT1? Can you use this protein as a biomarker in blood for the status of bone formation?. Lee and his colleagues came to this study with a long history of studying diseases that result in brittle bones. They and others have known for a long time that most families with children who had the genetic brittle bone disease osteogenesis imperfecta (OI) often carry mutations in type I collagen, the most abundant protein in bone.. However, in 2006, their work on families with unknown causes of brittle bone diseases led to the discovery of the first new genes for the disease in over two decades. This has since led to a string of discoveries by them and others on how genes in connective tissues control bone growth. In this, perhaps their most surprising ...
Unless closely monitored, renal bone disease (renal osteodystrophy) is a problem that will be experienced by most people suffering from end stage renal disease (ESRD). Renal bone disease is a complex issue and involves many more factors than can be listed in this limited space. Only the very basics are outlined here. First, the kidneys are involved in the synthesis of vitamin D, which is the most essential factor regulating intestinal absorption of calcium in humans. When the kidneys fail and less vitamin D is created, the amount of calcium absorbed by the intestines is reduced. Calcium is most essential substance for bone maintenance and health. Next, calcium and phosphorus levels in the blood (which are normally regulated by the kidneys) are dependent upon each other. Therefore, when the kidneys fail and the phosphorus level in the blood goes up, the (free) calcium level in the blood decreases. In response to these two factors that lower serum calcium, the body then increases the parathyroid ...
An achy bone. Constipation. Severe thirst. While these symptoms might not seem to have anything in common, they can all signify more serious conditions, including Metastatic Bone Disease (MBD). Many cancers that start in one place can spread (metastasize) to other areas of the body. When it spreads to the bone, its called MBD.MBD occurs…
Symptoms of lytic bone lesions vary since many different diseases can cause them. Typical symptoms include pain, pathologic bone fractures and high blood calcium, according to MedicineNet. Pathologic...
Metastatic bone disease arises from the spread of certain cancers to the skeletal system. The sarcoma care team assesses impending fracture and coordinates care.
Cameron TL, Bell KM, Gresshoff IL, Sampurno L, Mullan L, Ermann J, Glimcher LH, Boot-Handford RP, Bateman JF. XBP1-Independent UPR Pathways Suppress C/EBP-ß Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease. PLOS GENETICS 11 (9) : e1005505(2015) PubMed (Grant IDs: 607398 ...
This is the Condition and Disease - Bone Disease page of Green day directory. Submit your Condition and Disease - Bone Disease related sites here, or search for other Condition and Disease - Bone Disease related sites. Browse our Condition and Disease - Bone Disease section with many interesting sites
The method of laser osteoperforation was developed in experiment and then applied for treatment of 508 patients with osteomyelitis, 51 patients with nonunion and pseudo-joint and 34 patients with different forms of osteochondropathy. The clinical trial proved the efficiency of laser osteoperforation for treatment of both inflammatory and destructive bone diseases. This method is minimally invasive, promotes rapid reduction of bone and soft tissue inflammation, and apparently stimulates bone reparation ...
A growth of osteoclasts is inhibited by orally administering a liposomal lactoferrin. Thus a bone disease in which the osteoclast is involved is effectively prevented or treated by orally administerin
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OBJECTIVES Identify main functions of bone tissue Identify the major parts of a long bones Describe the cells found in bone tissue Describe the components of an osteon Compare and contrast intramembranous and endochondral ossification.
Dr. Bart Williams is Director of the Center for Cancer and Cell Biology and Professor for the Program in Skeletal Disease and Tumor Microenvironment at the Van Andel Research Institute (VARI).. Dr. Williams research focuses on understanding how alterations in the Wnt signaling pathway cause human disease. A specific focus of his lab is characterizing the role of Wnt signaling in bone formation during normal development and in the face of some common tumor types (for example, prostate, breast, lung, and renal tumors) that metastasize to and grow in bone. The Williams Lab has developed many valuable genetic models of bone disease including osteoarthritis and fracture repair and is working towards identifying novel genes that play key roles in skeletal development and maintenance of bone mass.. Dr. Williams joined VARI as a Scientific Investigator in July 1999. He became a Professor in 2006 and was named Director of the Center for Cancer and Cell Biology in 2010. Dr. Williams was a postdoctoral ...
We move on to Skeletal Disorders and Diseases in dogs in our SlimDoggy Health Check Series. Wikipedia provides a long list of potential issues, we will take a look at the most common. Osteoarthritis:Just as in humans, arthritis is a degenerative disease caused by the deterioration of the cartilage surrounding our
Vanishing bone disease (Gorham-Stout syndrome) is a rare entity of unknown etiology, characterized by destruction of osseous matrix and proliferation of vascular structures, resulting in destruction and absorption of bone. Despite the extensive investigation of the pathogenetic mechanisms of the disease, its etiology hasnt been clarified and several theories exist. The syndrome can affect one or multiple bones of the patient, including the skull, the upper and lower extremities, the spine and pelvis. The clinical presentation of a patient suffering from vanishing bone disease includes, pain, functional impairment and swelling of the affected region, although asymptomatic cases have been reported, as well as cases in which the diagnosis was made after a pathologic fracture ...
A bone with osteoporosis Scientists hope their findings could help to treat common forms of osteoporosis. This photo is taken from BBC.
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The third edition of Dr. Greenfields book suffers in scope and completeness when compared to two other recent multivolume texts on the same subject. Newer modalities, including nuclear imaging, computed tomography, and angiography, are only briefly discussed. The organization of the text is based on roentgen characteristics and is excellent as are the bibliography and indexing. The quality of many of the illustrations is poor and in some the important information is barely visible. ...
If you have a large or giant breed puppy, you may already be aware that it will not reach its full adult stature until 18 to 24 months. Normal growth spurts of …
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Professor Serena Bests Bioactive Materials for Skeletal Repair lecture for the London Materials Society considered degenerative bone disease and how materials research can help
Looking for online definition of hypophosphatemic bone disease in the Medical Dictionary? hypophosphatemic bone disease explanation free. What is hypophosphatemic bone disease? Meaning of hypophosphatemic bone disease medical term. What does hypophosphatemic bone disease mean?
consists of a mixture of osteomalacia, hyperparathyroid bone disease, osteoporosis and osteosclerosis. Osteomalacia results from failure of the kidney to convert cholecalciferol to its active metabolite 1,25 dihydroxycholecalciferol. A deficiency of the later leads to diminished intestinal absorption of calcium, hypocalcemia and reduction in the calcification of osteiod. Osteitis fibrosa results from secondary hyperparathyroidism, the parathyroid glands being stimulated by the low plasma calcium and possibly also by hyperphosphataemia. In some patients tertiary or autonomous hyperparathyroidism develops. Osteoporosis occurs in many patients possibly related to mild malnutrition. Osteosclerosis is seen mainly in the sacral area; at the base of the skull and in the vertebrae; the cause of this unusual reaction is not known ...
In a retrospective study, we have assessed the efficacy of oral calcitriol on the evolution of hyperparathyroid bone disease in patients on hemodialysis. 33 patients who had received calcitriol for at least one year and up to 7 years were carefully matched with controls for gender, years on
TY - JOUR. T1 - International myeloma working group recommendations for the treatment of multiple myeloma-related bone disease. AU - Terpos, Evangelos. AU - Morgan, Gareth. AU - Dimopoulos, Meletios A.. AU - Drake, Matthew T.. AU - Lentzsch, Suzanne. AU - Raje, Noopur. AU - Sezer, Orhan. AU - García-Sanz, Ramón. AU - Shimizu, Kazuyuki. AU - Turesson, Ingemar. AU - Reiman, Tony. AU - Jurczyszyn, Artur. AU - Merlini, Giampaolo. AU - Spencer, Andrew. AU - Leleu, Xavier. AU - Cavo, Michele. AU - Munshi, Nikhil. AU - Rajkumar, S. Vincent. AU - Durie, Brian G.M.. AU - Roodman, G. David. N1 - Publisher Copyright: © 2013 by American Society of Clinical Oncology. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2013/6/20. Y1 - 2013/6/20. N2 - Purpose The aim of the International Myeloma Working Group was to develop practice recommendations for the management of multiple myeloma (MM) -related bone disease. Methodology An interdisciplinary panel of clinical experts on MM and myeloma ...
This clinic treats patients who have metabolic bone diseases - thin bones, thick bones, soft bones, brittle bones and irregular bones. These diseases are caused by problems with mineral metabolism, nutrition, and some genetic diseases. In addition to the above list, we see patients with many kinds of diseases, including:
Tumor-induced bone disease is common among patients with advanced solid cancers, especially those with breast, prostate, and lung malignancies. The tendency of these cancers to metastasize to bone and induce bone destruction is, in part, due to alterations in integrin expression and signaling. Substantial evidence from preclinical studies shows that increased expression of integrin αvβ3 in tumor cells promotes the metastatic and bone-invasive phenotype. Integrin αvβ3 mediates cell adhesion to several extracellular matrix proteins in the bone microenvironment which is necessary for tumor cell colonization as well as the transmission of mechanical signals for tumor progression. This review will discuss the αvβ3 integrin receptor in the context of tumor-induced bone disease. Specifically, the focus will be the role of αvβ3 in modulating cancer metastasis to bone and tumor cell response to the bone microenvironment, including downstream signaling pathways that contribute to tumor-induced osteolysis.
Results Data from the first fifteen babies is presented.. Using an ALP cut-off of 400 IU/L to define osteopenia, babies with increased ALP, tended to have a higher PTH (p = 0.07), with mean PTH,7.9 pmol/L being associated with bone disease. Hypophosphatemia (Phosphate,1.5 mmol/l), a known risk factor, was significantly associated with hyperparathyroidism (p = 0.005). PTH and TmP-GFR were inversely correlated. Plasma calcium remained unchanged and within normal range. ...
Washington D.C. [USA], Nov 14 (ANI): A simple colour-changing test to detect fluoride in drinking water could in the future prevent the crippling bone disease, skeletal fluorosis, in developing countries such as India and Tanzania.
A fast colour-changing test that detects fluoride in drinking water could help prevent the crippling bone disease skeletal fluorosis in developing countries, say UK researchers. Jim Drury has more.}
If your child has a bone tumor or other bone disease, he or she will receive the best care at an academic medical center like NewYork-Presbyterian/Morgan Stanley Childrens Hospital. Our dedicated pediatric orthopedic specialists are known around the world for their expertise in caring for young patients, using treatments based on the latest medical findings.
Massachusetts Institute of Technology (MIT) researchers have for the first time carried out a multi-scale analysis to shed light on how bones material flaws lead to brittle bone disease.
Handmade, old-fashioned dolls crafted by Gardner, Kan., couple Jesse and Pat Wilkerson benefit brittle bone disease research by aiding the Osteogenesis Imperfecta Foundation.
Anna Ugarph from the research group Growth and Metabolism will defend her thesis Bone disease and Diabetes Mellitus on September 22, 2017. Main supervisor is Professor Kerstin Brismar. What is the main focus of your thesis? Bone disease and Diabetes Mellitus.
There are many essential nutrients in the growing foal ration and studies have shown that there is a strong correlation between the occurrence of skeletal disease in foals and weanlings and reduced amounts of calcium, phosphorus, copper, and zinc. Research has shown that the incidence of skeletal disease decreases significantly when these minerals (particularly copper) were increased to optimal levels in the diet. In further support of this research, studies have shown that following optimal copper and zinc supplementation to the mare in the last trimester, reductions in the incidence of osteochondritis dissecans (OCD), physitis, angular/flexural and cartilage defects of the limb in the foal have been reported.. Adequate amounts of calcium and phosphorus must also be available for bone formation to occur. In the absence of adequate quantities of calcium or phosphorus, endochondral cartilage becomes thickened, bone density and growth decrease and skeletal disease may occur. The ration must not ...
Metabolic bone diseases are disorders of bone strength, usually caused by abnormalities of minerals (such as calcium or phosphorus), vitamin D, bone mass or
Significant difference (p,0.001) is noted between phosphate-treatment and untreated groups for both GA and BW: Median 27weeks and 929g for treated subjects versus 29.6weeks and 1343g if untreated. In the phosphate-treatment group, ALP levels improved (mean pre-treatment414U/l and post-treatment264U/l, p=0.0006) and difference in phosphate levels were also significant with p=0.003. Between phosphate-treatment group versus untreated group, differences were insignificant for ALP (p=0.05) and phosphate levels (p=0.09), though this may reflect insufficient subsequent MBD screens (treatment group, n=15 versus untreated group, n=7). ...
Detailed information on bone cancers, including chondrosarcoma, ewings sarcoma, myeloma bone disease, multiple myeloma, and osteosarcoma
Peter Croucher manages a highly competitive research group with an international reputation for research in bone cell biology, tumour-induced bone disease and its clinical translation. This includes research into the understanding how tumours grow in bone and cause bone disease, particularly the haematological malignancy multiple myeloma, and breast and prostate cancer bone metastasis.
This 2 arm study will compare the efficacy of a regimen of intravenous (iv) and oral Bondronat with that of zoledronic acid in patients with malignant b
Bone disease. People with renal failure develop weaken bones from abnormal mineralization of the bone. Renal osteodystrophy is the name of this process where calcium and phosphorus do not deposit into the bone correctly and therefore the persons bones are prone to fractures ...
Abstract. Multiple myeloma (MM) patients develop devastating osteolytic bone disease causing non-healing bone fractures and pain. MM cells in the bone marrow m
If you have even broken a bone, then you know the pain that is involved. Perhaps your break was so bad that you had to have surgery on it to make sure the bone could successfully repair itself. Then, of course, there was the cast that you had to wear afterwards.
If you have even broken a bone, then you know the pain that is involved. Perhaps your break was so bad that you had to have surgery on it to make sure the bone could successfully repair itself. Then, of course, there was the cast that you had to wear afterwards.
Measurements of total body myeloma cell number and osteoclast activating factor (OAF) production by bone marrow myeloma cells in vitro were made in 33 patients with plasma cell myeloma. There was a highly significant correlation (P | 0.001) between t
In 1990 the bone condition called osteopenia - slight thinning of the bones - didnt exist. Today all over America women are diagnosed with osteopenia and given medication. This is the story of how a drug companys marketing efforts changed the definition of a disease and created a new category of people who saw themselves as needing treatment. Katie Benghauser was diagnosed with osteopenia and takes Fosamax.
Experts at the Scientific Advisory Committee on Nutrition (SACN) are urging the UK public to consider taking a daily supplement of vitamin D.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Bone and Cancer ( Topics in Bone Biology ) by Felix Brooner Pages: 273 Publisher: -- Edition: 1st., Vol. 5, 2009 Language: English
While supplementing your diet with Calcium and Vitamin D is proven to bring down risk of osteoporosis, as well as catalyze effective treatment in patients, Osteoporosis is a disease of multiple variables. Excessive smoking and alcohol consumption, for example, can increase your risk of falling prey to this bone disease. Even extended working hours can affect your back and you can get prone to catching this disease.. Try to avoid any inconsistency in your schedule in order to stay away from this serious disorder. Make sure youre sleeping adequately for the day and your sleeping posture isnt doing any harm to you. Sometimes, just the lack of a quality mattress can be such a nuisance that you rise the next day feeling your back and spinal cord absolutely stiff. provides the top mattress articles available today so that you buy the best out of the lot.. If you are susceptible to or have osteoporosis, make sure to consult your medical provider to address all the variables relevant ...
ICD-9 code 715.80 for Osteoarthrosis involving or with more than one site but not specified as generalized and involving unspecified site is a medical
Osteoporosis is a rather common bone disease that affects older women and men. It affects more than 10 million people in our nation - mostly women. Unfortunately, rarely do they receive treatment until its too late. In Brittle Bones?: Take An Aggressive Stance Barry Bittman, M.D. provides practical dos and donts for prevention and treatment.
A research group led by Professor Hannes Lohi at the University of Helsinki and Folkhälsan Research Center has uncovered a new skeletal disease in dogs. The disease was recognized in the Karelian Bear Dog breed and associated with an autosomal recessive defect in the alkaline phosphatase gene, ALPL.
Dwarfism is a condition which can affect people congenitally or take place due to certain dysfunctions in the organism such as hormone imbalances, organ dysfunction, bone diseases etc.
Patients on kidney dialysis and long-term intravenous feeding frequently suffer a painful bone disease apparently caused by aluminum in solutions used in treatment, researchers have found.Dr. Gordon
Arthritis is a degenerative bone disease which can affect the canine family. This article provides a brief overview of the causes, symptoms, and treatment options of this disease in dogs.
Taking x-rays is a great way to get a look inside your body and see what is really happening in the spine and joints. It can not only help us detect subluxations, but it can also give us clues to other things that may be happening within your body that you dont know about. Sometimes we will find what is called a congenital anomaly, which is often a minor abnormality that has no medical or cosmetic impact on a person. Other times, x-rays will reveal old fractures or injuries that you didnt even know happened. In rare cases, x-rays can show us that there is a pathology present, such as bone disease or cancer. In this instance, you will be given a referral to a specialist that can assist you with your condition. ...
A 47-year-old Michigan woman developed a bone disease rarely seen in the U.S. after she drank a pitcher of tea made from at least 100 tea bags daily, for 17 years, :| researchers report. The Detroit woman visited the doctor after experiencing pain in her lower back, arms, legs and hips for five y... Selokambang swimming pool is about 6km from west of Lumajang. The visitors can enjoy the beautiful, fresh and natural panorama. The society around it believe that the water can be recovered kinds of diseases, for example skin disease, rheumatic, bone disease, etc. The facilities are swimming pool special for adult, children, fishing area and graceful swans. Visit Selokambang swimming pool with your family and enjoy
BeWellBuzz) Food is the key ingredient for a human being to survive, but survival isnt everything unless you combine it with healthy survival. To stay fit and healthy, we need to consume foods that are rich in nutrients that are good for our body and mind. Why Do We Need Bone-Building Foods? Bone building is a lifelong process, and if you take action now, you can ... Continue Reading ...
  • Appropriate accumulation of these minerals (calcium, phosphorous and magnesium) in the bone help the body reach an optimal peak bone mass in young adulthood and decrease the likelihood of osteoporosis in old age. (
  • Although physical injury, causing fracture , dominates over disease , fracture is but one of several common causes of bone disease, and disease is in fact a common cause of fracture. (
  • In adults, an extremity affected by nerve injury gradually develops osteopenia (a reduced amount of bone tissue), so that it fractures easily. (
  • Bone disease in multiple myeloma (MM) is characterized by lytic bone lesions, which can cause severe bone pain, pathologic fractures and hypercalcemia. (
  • However, the lytic bone disease in MM differs from that in other cancer patients who have lytic bone metastases. (
  • The basis for this severe imbalance between increased osteoclastic bone resorption and decreased bone formation has been a topic of intensive investigation over the last several years and will be reviewed in this article. (
  • Gum and bone disease, otherwise known as periodontal disease, affects over 60 million American adults to some degree every year. (
  • Pathogenesis of myeloma bone disease. (
  • Although increased osteoclastic bone destruction is involved in MM and other tumors involving bone, in contrast to other tumors, once the MM tumor burden exceeds 50% in a local area, osteoblast activity is either suppressed or absent. (
  • Inactivity has a profound effect on the bone tissue , probably because the mechanical stimulus to bone formation is decreased. (
  • Gum and bone disease refers to bacterial infections in the gum and tissue around your teeth. (
  • With periodontitis, the bacterial infection in your gums reaches deeper areas within the tissue pockets, affecting the bone that supports your teeth. (
  • Diseases and injuries of bones are major causes of abnormalities of the human skeletal system . (
  • Several medical conditions may compromise bone health including anorexia nervosa, amenorrhea, parathyroid disorders, inflammatory bowel disease, celiac disease, immobilization, inability to bear weight due to developmental delay or paralysis, over-active thyroid (hyperthyroidism), Cushing's disease and certain medications. (
  • Good bone health depends upon nutrition, enough vitamin D and calcium, balanced hormones and weight bearing activity. (
  • Because the disease affects every person differently, Dr. Bien works with you to craft an individualized, noninvasive treatment plan that uniquely fits your lifestyle. (
  • In osteoarthritis , because the weight distribution across the knee or hip joints is uneven, the bone beneath the cartilage thickens on the compression side of the joint and atrophies on the extension side. (
  • You're more at risk of contracting gum and bone disease if you're a frequent smoker, a woman experiencing hormonal changes, or have been diagnosed with diabetes, AIDS, or cancer. (
  • Shiley H. Bien, DMD, and the team at Greenhills Dental Care help men and women living in and around Fremont, California, craft a healthier oral hygiene regimen and provide them with comprehensive periodontal treatment to combat gum disease. (
  • Childhood and adolescence are crucial years for the accrual of minerals necessary for bone health. (
  • HD Bone Diseases App is simply a source of information about the human musculoskeletal system and some of its diseases/conditions. (
  • There is a gallery of 10 pictures but there is no label showing what type of condition these relate to and there is no user interaction other than the facility to read and learn about certain musculoskeletal diseases. (
  • Poliomyelitis affecting the lower extremity in children results in short, thin bones with sometimes severe leg-length discrepancy. (
  • Additionally, you're also at a higher risk if you have a family history of gum and bone disease or have been prescribed medication that reduces the flow of saliva. (
  • For larger bone lesions, treatment may include medication, physical therapy and/or surgery. (
  • Multiple myeloma (MM) is a malignancy of plasma cells characterized by growth in the bone marrow (BM) environment and the development of lytic lesions in the skeleton. (
  • The hallmark of MM bone disease is the development of osteolytic lesions without associated osteoblastic activity. (
  • The absence of reactive bone formation renders MM-associated skeletal lesions silent on bone scan, and helps to explain the. (
  • They found that myeloma cells produced large amounts of an enzyme called thymidine phosphorylase (TP) that correlated with more severe bone lesions in patients. (
  • Treating myeloma-bearing mice with TP inhibitors markedly reduced bone lesions, raising the possibility of repurposing these drugs to treat cancer-driven bone disease. (
  • Central lesions with a 50% symmetrical loss of bone produce a 60% loss of bending strength. (
  • A strong case be made for also treating asymptomatic patients with involvement of long bones, vertebrae or base of skull, patients with significant osteolytic lesions, and perhaps all younger patients. (
  • Bone metastases in breast cancer: higher prevalence of osteosclerotic lesions. (
  • one or more lytic bone lesions detected on CT scan, including whole-body low-dose CT or PET/CT. (
  • Focal lesions are early, abnormal areas in the bone marrow that signal the development of a lytic lesion within the next 18-24 months. (
  • Lytic lesions are areas where bone has been destroyed, leaving a hole in the bone. (
  • Lytic lesions in the long bones of the leg or in the hip may require surgery to reinforce and stabilize the bone. (
  • MRI (magnetic resonance imaging) is a sensitive study for detecting early focal lesions in the bone marrow. (
  • of the disease from the skin lesions and facial disfiguration that it can cause. (
  • Nomenclature of Subchondral Nonneoplastic Bone Lesions. (
  • Bone diseases and injuries were formerly regarded as conditions that were more mechanical than metabolic. (
  • Moreover, adverse cardiovascular and metabolic outcomes in patients with psoriasis or psoriatic arthritis might be directly linked to the cutaneous and musculoskeletal manifestations of these diseases via subsets of circulating monocytes and tissue macrophages activated by inflammatory cytokine networks that arise in the skin and possibly the joint. (
  • In addition to this, bone also contains osteocyts, which helps in metabolic exchange with the blood that flows through bone tissues. (
  • These images are a random sampling from a Bing search on the term "Metabolic Bone Disease Following ICU Admission. (
  • Throughout your time in our care, the doctors of the Metabolic Bone Diseases Clinic will take the time to get to know you so that they can tailor treatment strategies to your needs and lifestyle. (
  • Additionally, we work closely with other Departments to provide care for patients who have complex metabolic bone disease. (
  • The Metabolic Bone Disease Fellowship program within the combined orthopaedic, medical and radiology bone consortium represents the continued commitment of Hospital for Special Surgery to train clinicians and scientists in basic and applied research. (
  • The HSS Metabolic Bone Disease Fellowship is designed to provide the participant with an ongoing, in-depth experience in the medical management of patients with metabolic bone disease. (
  • Previous training for the Metabolic Bone Disease Fellowship includes all medical residencies and fellowships, physical medicine and rehabilitation, radiology, pathology and orthopaedic surgery. (
  • The Metabolic Bone Disease Fellows are the primary surgeons on service cases under the supervision of the attending staff and are the primary assistants to the attending physician on private operative cases. (
  • Alkaline phosphatase levels are routinely measured in dialysis patients to monitor for metabolic bone disease, a common complication of CKD. (
  • Based in the Department of Endocrinology, the Metabolic Bone Disease & Endocrine Calcium Center provides superior access to a multidisciplinary team, providing Center-of-Excellence DXA bone density testing and interpretation, on-site laboratory testing, and a fully staffed infusion center for even the most sophisticated testing and drug administration requirements. (
  • The Metabolic Bone Disease & Endocrine Calcium Center team has partnered with their highly skilled Endocrine Surgery colleagues to provide timely, integrated assessment of parathyroid abnormalities with ultrasonography, direct laryngoscopy, and other state of the art testing. (
  • The Metabolic Bone Disease & Endocrine Calcium Center and the Department of Endocrine Surgery continue to collaborate to provide comprehensive pre-surgical assessment, timely surgical intervention, and post-surgical follow up for all patients with parathyroid disease in their care. (
  • The Metabolic Bone Disease & Endocrine Calcium Center addresses problems associated with the regulation of the body's bone, mineral and hormone functions. (
  • Paget's disease of bone (commonly known as Paget's disease or historically, osteitis deformans) is a condition involving cellular remodeling and deformity of one or more bones. (
  • Paget's may first be noticed as an increasing deformity of a person's bones. (
  • Bone diseases affect normal growth, development or remodeling leading to weakness and/or deformity. (
  • This creates a tiny rift in the tissue, which when repeated in many molecules, leads to brittle tissue, broken bones, deformity and, in the most severe form of the disease, death. (
  • 1 The disease results in bone expansion and structural weakness, which can cause pain, deformity, and a range of complications. (
  • Chronic graft-versus-host-disease (cGVHD) is a frequent and severe complication of allogeneic hematopoietic stem cell transplantation (AHSCT). (
  • Graft-versus-Host disease (GVHD) often occurs after allogeneic bone marrow transplants (BMT). (
  • The number of patient who develop acute graft-versus-host disease (GVHD). (
  • The number of patient who develop chronic graft-versus-host disease (GVHD). (
  • VANCOUVER, WASHINGTON (November 14, 2017) - Newly published research provides preclinical proof-of-concept for the ability of PRO 140, a humanized anti-CCR5 monoclonal antibody under development by CytoDyn Inc. (OTC.QB: CYDY), to effectively block the development of graft-versus-host disease (GvHD), a potentially lethal complication of bone marrow stem cell (BMSC) transplantation. (
  • Graft-versus-host disease is a risk when patients receive bone marrow stem cells donated from another person. (
  • Graft-versus-host disease (GvHD) is a syndrome, characterized by inflammation in different organs. (
  • In the clinical setting, graft-versus-host-disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (
  • In the classical sense, acute graft-versus-host-disease is characterized by selective damage to the liver, skin (rash), mucosa, and the gastrointestinal tract. (
  • Newer research indicates that other graft-versus-host-disease target organs include the immune system (the hematopoietic system, e.g., the bone marrow and the thymus) itself, and the lungs in the form of immune-mediated pneumonitis. (
  • Chronic graft-versus-host-disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands. (
  • The chronic form of graft-versus-host-disease (cGvHD) normally begins 90 to 600 days post-transplant. (
  • Graft-versus-host-disease-associated oral cancer may have more aggressive behavior with poorer prognosis, when compared to oral cancer in non-hematopoietic stem cell transplantation patients. (
  • Rarely, a bone affected by Paget's disease can transform into a malignant bone cancer. (
  • Other symptoms may occur, depending on which part of the body is affected by Paget's disease. (
  • Bones affected by Paget's disease can also be painful. (
  • Genetic causes may or may not involve a family history of Paget's disease. (
  • The Division of Bone Marrow Transplantation and Immune Deficiency at Cincinnati Children's is an international leader in delivering cutting-edge therapies for many diseases such as refractory, or hard-to-treat, cancers, rare genetic conditions affecting the immune system, hemoglobinopathies and bone marrow failure syndromes. (
  • Medical experts may be able to solve the mystery behind a rare bone disease after two ancient skeletons with the genetic bone disease were unearthed from a medieval Irish graveyard. (
  • Brittle bone disease is a lifelong genetic disorder that causes your bones to break very easily, usually without any type of injury, as from a fall. (
  • Genetic testing can confirm brittle bone disease. (
  • Anomalies of the expression of T-cell receptor variable genes in haemochromatosis: an MHC-class I linked genetic disease of iron overload. (
  • The cause of Paget's disease is unknown, but there is a strong genetic influence. (
  • There is a strong genetic component, and 15%-20% of those affected have a first-degree relative with the disease. (
  • The new discovery improves the genetic diagnosis of the disease and paves the way to possible improved treatment options for patients. (
  • Dr Lee added: "We now have a deeper understanding for how genetic mutations that affect collagen and collagen processing enzymes cause weak bones. (
  • MPNs are caused by genetic changes (mutations) of the hematopoietic cells in the bone marrow that are acquired spontaneously, due to certain genetic predispositions or as a result of environmental influences. (
  • Using DNA extracted from the bone marrow, researchers did a whole-genome analysis which determined that she was South American, "with genetic variations that identified her as being from the Andean region inhabited by the Chilean Chilote Indians," said the report. (
  • The results revealed four new SNVs - a type of genetic mutation at the individual level - in genes that were known to cause bone diseases, like scoliosis or dislocations, as well as two more SNVs in genes involved in producing collagen. (
  • It is caused by a genetic defect that affects type 1 collagen, an important building block of bone. (
  • In osteoarthritis , because the weight distribution across the knee or hip joints is uneven, the bone beneath the cartilage thickens on the compression side of the joint and atrophies on the extension side. (
  • Signs of Paget's disease of bone include: pain associated with bones and joints, headaches, hearing loss, enlargement or bowing of bones, tingling or numbness. (
  • Brittle bone disease affects about one in 16,000 people worldwide, and defective collagen is implicated in many other medical conditions, including Alport syndrome (kidney disease) and Ehlers-Danlos syndrome (overly-flexible skin and joints). (
  • Splints or braces to support your bones and joints and to help keep weak bones from breaking. (
  • Sore joints or arthritis due to damage to the cartilage which lines the ends of bones. (
  • Bone pain, an aching of the joints and headaches are all symptoms of bone marrow disease. (
  • My pains presented as what feels like deep bone or toothache like pains that jump all over the place in my bones and joints. (
  • This disease causes crippling deformities of the spine and joints, especially in children whose skeletons are still forming. (
  • Whenever the body needs to move bones, bones work with muscles, tendons and ligaments to form joints and simple machines called levers. (
  • It is often difficult to determine whether a bony defect found during a bone survey for metastatic disease is the result of that disease or of some other condition. (
  • Metastatic bone disease: a guide to good practice (2015 revision). (
  • Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. (
  • Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons and cancer specialists alike. (
  • Substantial evidence from preclinical studies shows that increased expression of integrin αvβ3 in tumor cells promotes the metastatic and bone-invasive phenotype. (
  • This page gives you information about metastatic bone disease and its treatment. (
  • The team can offer specialist surgery for metastatic bone disease and can help to confirm the diagnosis of metastatic bone disease when it is important to do so. (
  • Chronic dental problems may lead to infection of the jaw bone. (
  • Paget's disease of bone is an uncommon, chronic bone disorder that occurs in only about one percent of people in the United States and slightly more often in men than in women (three to two). (
  • Osteomyelitis refers to a bacterial bone infection, which can either be acute or chronic. (
  • Paget disease of the bone is a chronic bone disorder. (
  • As the ARV medicines have changed HIV/AIDS from a fatal illness to a chronic one, people with HIV/AIDS are aging and experiencing some of the same bone diseases that older people who don't have HIV develop. (
  • SGH renal department provide a dedicated renal bone specialist in managing patients with wide range of bone disease related to chronic kidney disease. (
  • Although HO is not life-threatening, the bone growths can press against nerves and blood vessels, resulting in chronic pain, limited motion, problems fitting prosthetic limbs and other complications. (
  • MPNs are chronic diseases with only 1 to 2 new cases diagnosed per 100,000 people every year. (
  • THURSDAY, July 31 -- High levels of alkaline phosphatase -- a routinely measured marker of bone disease -- may signal an increased risk of death among patients receiving dialysis for chronic kidney disease, say U.S. researchers. (
  • It can also lead to bone deformities. (
  • This makes their bones fragile, but they don't have bone deformities. (
  • Children born with this type usually will be shorter than their peers, and may have severe bone deformities, breathing problems (which can be life-threatening), brittle teeth, a curved spine, ribcage deformities, and other problems. (
  • Although many people with PDB have no symptoms, bone deformities can lead to joint pain, bowing of the legs, headaches and hearing loss. (
  • The patients suffer from heightened bone fragility, bone deformities and stunted growth. (
  • The disease is named after Sir James Paget. (
  • The exact cause of Paget disease of the bone is unknown. (
  • What are the symptoms of Paget disease of the bone? (
  • Very rarely, Paget disease may progress to bone cancer. (
  • How is Paget disease of the bone diagnosed? (
  • Any condition of bone growth or an increased activity of bone cells, including Paget disease, will cause alkaline phosphatase levels to rise. (
  • How is Paget disease of the bone treated? (
  • However, this pain pattern can be present in patients with osteomyelitis and Paget disease, and in these instances, it is also nonspecific. (
  • The condition is named after Sir James Paget, a British doctor who described the disease in the 1870s. (
  • For other diseases named after Paget, see Paget's disease (disambiguation) . (
  • A computed tomography scan displayed a marked widening of the diploic space of the calvaria with lytic and sclerotic regions ( Figure , A and B), which is pathognomonic of advanced Paget disease affecting the skull. (
  • Effective and safe treatment methods can help most people with Paget's disease. (
  • The viruses linked to measles in people and distemper in dogs have been found in the bones of people with Paget's disease. (
  • Most people with Paget's disease have no symptoms. (
  • Many people with Paget's disease are unaware they have the condition because they have no symptoms or only mild symptoms. (
  • A very rare complication in less than 1% of people with Paget's disease is the development of bone cancer in the abnormal bone. (
  • Some people with Paget's Disease do not have any symptoms, while others do. (
  • Two genes, SQSTM1 and RANK, and specific regions of chromosome 5 and 6 are associated with Paget's disease of bone. (
  • Three genes linked to the development of Paget's disease, a painful bone condition, have been identified by an international team of scientists, led by the University of Edinburgh. (
  • TP triggered epigenetic changes in the expression of osteoblast as well as osteoclast differentiation-associated genes, leading to both blunted bone growth and bone breakdown. (
  • These activated pro-teins bind to the DNA and regulate genes involved in the bone and sterol metabolism and the regula-tion of cell stress. (
  • Nolas said "a relatively short list of mutations in genes known previously to be associated with bone development" were found in genes related to dwarfism, scoliosis, and musculoskeletal abnormalities. (
  • Although there is no cure for Paget's disease, medications (bisphosphonates and calcitonin) can help control the disorder and lessen pain and other symptoms. (
  • Legg-Calvé-Perthes disease is a rare childhood bone disorder similar to osteonecrosis of the femoral head in adults. (
  • These types of complaints occur when a person with a bone marrow disorder has a very low red blood cell count. (
  • N. Medicine an inherited disorder characterized by extreme fragility of the bones. (
  • It is a rare, usually inherited disorder that causes bones to break easily due to the body's low production of collagen. (
  • Enthesopathy is a disorder of bone, tendon, or ligament insertion. (
  • Normally this makes it possible for another group of cells to rebuild the bone, renewing the skeleton and maintaining its strength as the body ages. (
  • But if the bone dismantlers become more active than the bone builders, weakening of the skeleton and bone loss result. (
  • This loss of osteopontin, a known potent inhibitor of mineralization (or calcification) in the skeleton and dentition, normally allows bones and teeth to mineralize and thus harden to meet the biomechanical demands placed on them. (
  • While not life-threatening, this decreased mineralization of the skeleton (osteomalacia), along with the soft teeth, soon leads to a waddling gait, short stature, bone and muscle pain, weakness and spontaneous tooth abscesses. (
  • These two actions - breakdown and build-up of bones - are coupled in a delicate interplay to ensure the health of the skeleton. (
  • The skeleton, discovered in a leather pouch behind an abandoned church, was pristine: a tiny figure, just six inches long, with a cone-shaped head, 10 pairs of ribs, and bones that looked like those of an 8-year-old child. (
  • While RANKL produced by bacteria-reactive lymphocytes is known to cause osteoclast-mediated pathogenic periodontal bone loss3-6 , molecular mechanism underlying the impaired alveolar bone regeneration in the context of periodontitis remains elusive. (
  • 13 , 14 Mutations in the SQSTM1/p62 gene are therefore a plausible cause of Paget's disease, but it is unclear how germline DNA mutations (present in every osteoclast) cause bone disease that is focal in nature. (
  • As we grow older, the osteoclast cells removes bone quicker than the osteoblast cells can produce it. (
  • Surprisingly, selective knockout of Fra-2 in the macrophage-osteoclast lineage did not show bone phenotypes in vivo, but isolated progenitor cells failed to differentiate in the absence of additional LIF. (
  • The loss of bone triggers the osteoblasts to rapidly produce more bone in an attempt to replace the extra bone being lost. (
  • At the same time, they prevent bone repair by inhibiting the formation of osteoblasts. (
  • Lee SM, Bae SK, Cho MR (2000) Acute osteomyelitis shown as a cold lesion on bone scan. (
  • Physicians usually obtain a non-invasive bone scan to determine the extent of bone involvement. (
  • It also predicts if the person requires a special X-ray test called 'bone densitometry or DEXA scan' to confirm the score index from the results of the chart. (
  • You may have a bone scan of your whole body to find out which bones are affected. (
  • An otherwise asymptomatic patient whose MRI scan shows more than 1 focal lesion of at least 5 mm in size has what is called a "myeloma-defining event," and should be treated for active disease. (
  • CT (computed tomography): Current NCCN (National Comprehensive Cancer Network) guidelines list skeletal survey or whole-body low-dose CT scan as the preferred studies for diagnosing myeloma bone disease, giving doctors the choice to do the more sensitive (and more expensive) CT study if insurance reimbursement is available. (
  • At first I thought for sure it was bone cancer and had a full body bone scan even. (
  • People with OI might have bones that break easily, which is why the condition is commonly called brittle bone disease . (
  • Indicative of the heredity consideration, Paget's disease occurs more commonly in European populations and their descendants. (
  • The disease most commonly affects the head of the thighbone, or femoral head. (
  • Less commonly, Paget's disease can affect the heart, because the abnormal new bone needs its own blood supply. (
  • GvHD is commonly associated with bone marrow transplants and stem cell transplants. (
  • Approximately 35% of patients with Paget's have symptoms related to the disease when they are first diagnosed. (
  • Paget's disease may be caused by a slow virus infection (i.e., paramyxoviridae) present for many years before symptoms appear. (
  • Symptoms may include localized bone pain, tenderness, redness and swelling as well as possible fever and chills. (
  • The man's symptoms, particularly his deformed fingers, are characteristic of a bone disease called skeletal fluorosis , which is caused by consuming too much fluoride. (
  • There is no cure for brittle bone disease, but treatment can relieve symptoms, prevent breakage of bones, and maximize movement. (
  • Your doctor may prescribe medicine if you have symptoms or if you have no symptoms but you are at risk for other problems from Paget's disease. (
  • The symptoms of colitis, such as swelling, anemia, and unhealthy increases in monocytes and neutrophils, (cells that fight infection but exacerbate the excessive swelling in intestines) were reflected in the bone marrow. (
  • The fact that these symptoms are only partially improved by the standard treatment with phosphate - which improves circulating phosphate levels - prompted the researchers to look for local factors within the bone that might be blocking mineralization in these patients. (
  • This bone disease does not have any symptoms. (
  • In Australia, about 2-4% of people over the age of 55 will have some degree of Paget's disease, although for most people it will cause no symptoms or major problems. (
  • The symptoms of Paget's disease depend on where in the body the abnormal new bone is being produced. (
  • Doctors diagnose the stage of the disease by closely watching for symptoms. (
  • Symptoms of each type of bone marrow disease will vary according to its severity, but tend to be similar in nature. (
  • Excessive fatigue and weakness are symptoms of anemia that may occur in patients with bone marrow disease. (
  • Ruxolitinib effectively controls the symptoms but does not offer a cure, as the malignant stem cell clone is located in the bone marrow and is generally not attacked. (
  • When comparing the various bone-lytic diseases, the common view emerges that accessory cells, such as T- and B-lymphocytes provide osteoclastogenesis stimulating factors. (
  • There is a hereditary factor in the development of Paget's disease of bone. (
  • Paget's disease of bone is associated with mutations in RANK. (
  • Hosking D J . Paget's disease of bone. (
  • Paget's disease of bone is common, affecting up to 4% of Australians over the age of 55 years. (
  • Michael Baum, emeritus professor of surgery at University College London, suggested that the sitter had Paget's disease of bone. (
  • Paget's Disease of Bone is a condition that occurs when bones fall apart and new, weaker bones are formed in their place. (
  • Gilday DL, Eng B, Paul DJ, et al (1975) Diagnosis of osteomyelitis in children by combined blood pool and bone imaging. (
  • Typically, it is the appearance of the bones on an X-ray that signals the physician to make the diagnosis. (
  • Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. (
  • A bone biopsy is often required to determine the actual diagnosis of such a defect. (
  • Provide a general approach to the diagnosis, management, and treatment of patients with a rheumatological, immunological, or allergic disease. (
  • There are no preventive treatments, but steroids are often prescribed to reduce the diseases' pain and inflammation. (
  • In this review, we discuss the role of inflammasomes in bone diseases caused by sterile or non-sterile inflammation. (
  • But if a person consumes a lot of fluoride, then over time, the fluoride forms crystal deposits on bone, leading to skeletal fluorosis. (
  • A fast colour-changing test that detects fluoride in drinking water could help prevent the crippling bone disease skeletal fluorosis in developing countries, say UK researchers. (
  • Washington D.C. [USA], Nov 14 : A simple colour-changing test to detect fluoride in drinking water could in the future prevent the crippling bone disease, skeletal fluorosis, in developing countries such as India and Tanzania. (
  • Whilst low amounts of fluoride are beneficial for healthy teeth, high levels of fluoride can weaken bones, leading to skeletal fluorosis. (
  • Drug therapies for peripheral joint disease in psoriatic arthritis: a systematic review," The Journal of Rheumatology , vol. 41, no. 11, pp. 2277-2285, 2014. (
  • Evidence that this disease is distinct from rheumatoid arthritis and other spondyloarthropathies is based on data derived from characteristic clinical features, histopathologic analyses, immunogenetic associations and musculoskeletal imaging. (
  • Male C282Y homozygotes with a serum ferritin level of 1000 mg/L or more were more likely to report fatigue, use of arthritis medicines, and a history of liver disease. (
  • The molecule we studied controls cells linked to bone weakening, but it belongs to a family of proteins implicated in conditions such as rheumatoid arthritis, psoriasis, Crohn's disease and asthma," said first author Julia Warren, an MD/PhD student. (
  • MDS is a group of diseases where there is abnormal bone marrow cell production. (
  • The abnormal bone formation is associated with recruitment of abnormal blood vessels, forcing the cardiovascular system to work harder (pump more blood) to ensure adequate circulation. (
  • Paget's disease is a problem of abnormal bone growth. (
  • As a result of new abnormal bone being produced, affected bones become enlarged and misshapen. (
  • Pain, numbness, weakness or paralysis in different parts of the body, due to the abnormal bone pressing on or pinching nerves in the spinal cord. (
  • This makes their bones weaker and more brittle than normal bones. (
  • Advanced Paget's disease may lead to other medical conditions, including: Osteoarthritis may result from changes in bone shape that alter normal skeletal mechanics. (
  • The dysregulation of miRNAs has been implicated in various human diseases such as brain tumor, osteoarthritis, schizophrenia, and breast cancer. (
  • Osteoarthritis may result from changes in bone shape that alter normal skeletal mechanics. (
  • Collagen is an important building block of bones. (
  • They either don't have enough collagen in their bones or have collagen that doesn't work as it should. (
  • This approach to the study of disease, referred to as "materiomics" by the lead researcher on the project, Professor Markus Buehler of MIT's Department of Civil and Environmental Engineering, could prove valuable in the study of other diseases "" particularly collagen- and other protein-based diseases "" where a material's behavior and breakdown play a critical role. (
  • Collagen is a protein in your body that forms and strengthens bones. (
  • PDB affects approximately 1 to 2 percent of white adults aged 55 or older, according to an April 2009 review article published in " Therapeutic Advances in Musculoskeletal Disease . (
  • Bhattacharya used the Human Phenotype Ontology (HPO), a database that links genomic data to the abnormal phenotypes found in human disease, everything from atrial septal defect, or a hole in the chambers of the heart, to musculoskeletal abnormalities. (
  • Mechanisms of disease: mechanisms of bone metastasis. (
  • Mundy GR, Yoneda T. Facilitation and suppression of bone metastasis. (
  • Bone Metastasis: Current State of Play. (
  • Blood tests taken most often will indicate an increase in serum alkaline phosphatase (SAP), which is reflective of the rapid new bone turnover. (
  • A blood test called serum alkaline phosphatase measures the levels of alkaline phosphatase (an enzyme found throughout the body) in the bone. (
  • The most important one for diagnosing Paget's disease is a blood test for alkaline phosphatase, an enzyme made by bone. (
  • In dialysis patients, increased levels of alkaline phosphatase in the blood indicate a so-called high-turnover bone disease, which can happen due to hormonal imbalance in CKD," said Kalantar-Zadeh, who added that previous studies have identified a possible link between bone disease and cardiovascular health in CKD patients. (
  • The researchers worked with RANKL, a protein that activates cells that dismantle bone. (
  • According to the researchers, their ability to do this suggests the approach may help design treatments for other diseases that are controlled by similar mechanisms. (
  • Researchers at McGill University and the Federal University of Sao Paulo have identified that osteopontin, a major bone and tooth substrate protein, plays a role in XLH. (
  • Cecilia Giunta and Marianne Rohrbach, both researchers from the Children's Research Center at the University Children's Hospital Zurich, their teams and colleagues from the USA and Thailand have now detected a new type of brit-tle-bone disease, identifying two families with a total of eight patients in all. (
  • Shortly afterwards, researchers dis-covered that IFAP syndrome, a group of rare dermatological diseases in humans, is caused by muta-tions in MBTPS2. (
  • April 11, 2013 - Researchers from the University of California, Davis (UC Davis), have launched a Phase I clinical trial of CD34+ bone marrow stem cells (BMSC) for people with retinal conditions that cause vision loss from ischemia, or loss of blood flow, and cell degeneration. (
  • Weak bones are not a natural part of aging. (
  • If you don't have enough of it, your bones become very weak and will break easily. (
  • Blood and urine tests will rule out other health conditions that can cause weak bones, such as rickets . (
  • But this new bone is often weak and brittle, and it breaks easily. (
  • another vital use of bones is a girders to which muscles may attach. (
  • Muscles provide the power to move the various limbs and body parts, but they can do so only by moving the bones relative to each other. (
  • I had terrible bone pain in my lower legs and it felt like it was in my back but I believe it was more ligaments, muscles, and nerves. (
  • When the arm is bent the lower arm bones represent the rigid bar, the elbow joint is the fulcrum, the hand is the weight that is moved, and the force is supplied by muscles on the anterior side (front) of the upper arm. (
  • Diagnosed in toddlers, X-linked hypophosphatemia (XLH) is the most common form of heritable rickets, in which soft bones bend and deform, and tooth abscesses develop because infections penetrate soft teeth that are not properly calcified. (
  • Patients who have rickets experience a softening and weakening of their bones traced to a vitamin deficiency. (
  • MDS syndromes are classified by how the cells in the bone marrow and blood smear look under the microscope. (
  • The culprit is a change in the bone metabolism, which no longer seems to be impaired in the case of dermatological diseases. (
  • The scientists hope to gain new insights into bone developments and sterol metabolism, which could one day mean improved treatment options for patients. (
  • It becomes painful when I lay a certain way, move my arms a certain way, and especially when I press on the bone. (
  • The affected bones show signs of dysregulated bone remodeling at the microscopic level, specifically excessive bone breakdown and subsequent disorganized new bone formation. (
  • Bone demineralization in cystic fibrosis: evidence of imbalance between bone formation and degradation. (
  • The doctors involved in the case suspected that their patient's abuse of dust spray may have been at least partly to blame for the rapid bone formation. (
  • Consequently, formation of bone-degrading cells was blocked. (
  • High concentrations of active TGF-β recruited mesenchymal stromal stem cells (MSCs) and led to excessive vessel formation, bone deterioration, and fibrocartilage calcification. (
  • Systemic inhibition of TGF-β activity by injection of 1D11, a TGF-β-neutralizing antibody, but not a vehicle antibody, attenuated the excessive vessel formation and restored uncoupled bone remodeling in SMTS mice. (
  • Most tumors that arise in the bones are noncancerous. (
  • Although increased osteoclastic bone destruction is involved in MM and other tumors involving bone, in contrast to other tumors, once the MM tumor burden exceeds 50% in a local area, osteoblast activity is either suppressed or absent. (