Diseases of BONES.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Bone loss due to osteoclastic activity.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.
Tumors or cancer located in bone tissue or specific BONES.
Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Dissolution of bone that particularly involves the removal or loss of calcium.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
Breaks in bones.
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.
Syndromes of bone destruction where the cause is not obvious such as neoplasia, infection, or trauma. The destruction follows various patterns: massive (Gorham disease), multicentric (HAJDU-CHENEY SYNDROME), or carpal/tarsal.
The process of bone formation. Histogenesis of bone including ossification.
A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.
Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
The largest of three bones that make up each half of the pelvic girdle.
Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.
A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.
A VITAMIN D that can be regarded as a reduction product of vitamin D2.
Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)
The grafting of bone from a donor site to a recipient site.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.
Diseases of the bones related to hyperfunction or hypofunction of the endocrine glands.
A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.
Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Abnormally high level of calcium in the blood.
Stable strontium atoms that have the same atomic number as the element strontium, but differ in the atomic weight. Sr-84, 86, 87, and 88 are the stable strontium isotopes.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
Death of a bone or part of a bone, either atraumatic or posttraumatic.
A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.
A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.
A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).
Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).
Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.
A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.
A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.
A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher.
An abnormal hardening or increased density of bone tissue.
Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).
Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.
One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.
Bone diseases caused by pathogenic microorganisms.
COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.
Inorganic compounds that contain TECHNETIUM as an integral part of the molecule. Technetium 99m (m=metastable) is an isotope of technetium that has a half-life of about 6 hours. Technetium 99, which has a half-life of 210,000 years, is a decay product of technetium 99m.
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.
Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
A coronary vasodilator agent.
A circular structural unit of bone tissue. It consists of a central hole, the Haversian canal through which blood vessels run, surrounded by concentric rings, called lamellae.
Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.
A condition of an abnormally low level of PHOSPHATES in the blood.
Inorganic salts of phosphoric acid.
Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.
The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.
Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
AMINO ACIDS composed of GLYCINE substituted at the nitrogen rather than the usual carbon position, resulting in the loss of HYDROGEN BONDING donors. Polymers of these compounds are called PEPTOIDS.
A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.
Formation of stones in the KIDNEY.
Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia.
The spinal or vertebral column.
Excision of one or more of the parathyroid glands.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The bone that forms the frontal aspect of the skull. Its flat part forms the forehead, articulating inferiorly with the NASAL BONE and the CHEEK BONE on each side of the face.
A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.
A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.
Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.
Elements of limited time intervals, contributing to particular results or situations.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.
Local surroundings with which cells interact by processing various chemical and physical signals, and by contributing their own effects to this environment.
A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.
Pathologic deposition of calcium salts in tissues.
Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.
A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.
A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.
The bones of the free part of the lower extremity in humans and of any of the four extremities in animals. It includes the FEMUR; PATELLA; TIBIA; and FIBULA.
A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
Removal of bone marrow and evaluation of its histologic picture.
Fractures of the femur.
The five cylindrical bones of the METACARPUS, articulating with the CARPAL BONES proximally and the PHALANGES OF FINGERS distally.
Inorganic or organic compounds that contain the basic structure RB(OH)2.
A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)
A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.
Tumors or cancer of the human BREAST.
The five long bones of the METATARSUS, articulating with the TARSAL BONES proximally and the PHALANGES OF TOES distally.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
The seven bones which form the tarsus - namely, CALCANEUS; TALUS; cuboid, navicular, and the internal, middle, and external cuneiforms.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
CCR receptors with specificity for a broad variety of CC CHEMOKINES. They are expressed at high levels in MONOCYTES; tissue MACROPHAGES; NEUTROPHILS; and EOSINOPHILS.
A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.
Cholecalciferols substituted with two hydroxy groups in any position.
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.
The TARSAL BONES; METATARSAL BONES; and PHALANGES OF TOES. The tarsal bones consists of seven bones: CALCANEUS; TALUS; cuboid; navicular; internal; middle; and external cuneiform bones. The five metatarsal bones are numbered one through five, running medial to lateral. There are 14 phalanges in each foot, the great toe has two while the other toes have three each.
Tumors or cancer of the PROSTATE.
LDL-receptor related protein that combines with FRIZZLED RECEPTORS at the cell surface to form receptors that bind WNT PROTEINS. The protein plays an important role in the WNT SIGNALING PATHWAY in OSTEOBLASTS and during EMBRYONIC DEVELOPMENT.
An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
The outer shorter of the two bones of the FOREARM, lying parallel to the ULNA and partially revolving around it.
A surgical specialty which utilizes medical, surgical, and physical methods to treat and correct deformities, diseases, and injuries to the skeletal system, its articulations, and associated structures.
A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.
Fibrous blood-filled cyst in the bone. Although benign it can be destructive causing deformity and fractures.
Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.
The giving of drugs, chemicals, or other substances by mouth.
The surgical removal of one or both ovaries.
A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
A bone morphogenetic protein that is a potent inducer of BONE formation. It plays additional roles in regulating CELL DIFFERENTIATION of non-osteoblastic cell types and epithelial-mesenchymal interactions.
The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
Progenitor cells from which all blood cells derive.
Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Implantable fracture fixation devices attached to bone fragments with screws to bridge the fracture gap and shield the fracture site from stress as bone heals. (UMDNS, 1999)
The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).
Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.
A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).

Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions: a randomized, placebo-controlled trial. Protocol 18 Aredia Breast Cancer Study Group. (1/1036)

PURPOSE: To assess whether pamidronate can reduce the frequency of skeletal morbidity in women with lytic bone metastases from breast cancer treated with hormone therapy. PATIENTS AND METHODS: Three hundred seventy-two women with breast cancer who had at least one lytic bone lesion and who were receiving hormonal therapy were randomized to receive 90 mg of pamidronate or placebo as a 2-hour intravenous infusion given in double-blind fashion every 4 weeks for 24 cycles. Patients were evaluated for skeletal complications: pathologic fractures, spinal cord compression, irradiation of or surgery on bone, or hypercalcemia. The skeletal morbidity rate (the ratio of the number of skeletal complications to the time on trial) was the primary efficacy variable. Bone pain, use of analgesics, quality of life, performance status, bone tumor response, and biochemical parameters were also evaluated. RESULTS: One hundred eighty-two patients who received pamidronate and 189 who received placebo were assessable. The skeletal morbidity rate was significantly reduced at 12, 18, and 24 cycles in patients treated with 90 mg of pamidronate (P = .028, .023, and .008, respectively). At 24 cycles, the proportion of patients having had any skeletal complication was 56% in the pamidronate group and 67% in the placebo group (P = .027). The time to the first skeletal complication was longer for patients receiving pamidronate than for those given placebo (P = .049). There was no statistical difference in survival or in objective bone response rate. Pamidronate was well tolerated. CONCLUSION: Treatment with 90 mg of pamidronate as a 2-hour intravenous infusion every 4 weeks in addition to hormonal therapy significantly reduces skeletal morbidity from osteolytic metastases.  (+info)

The aetiology of congenital angulation of tubular bones with constriction of the medullary canal, and its relationship to congenital pseudarthrosis. (2/1036)

It is suggested that there is a group of cases of congenital angulation of tubular bones in which the lesion is a defect of ossification of the primary cartilaginous anlage and in which neurofibromatosis is not implicated. It appears that in this group the prognosis with regard to the resolution of deformity and the prevention of pseudarthrosis with conservative treatment or relatively simple surgical procedures is better than that in the neurofibromatous type.  (+info)

Massive pelvic and femoral pseudotumoral osteolysis secondary to an uncemented total hip arthroplasty. (3/1036)

A 51 year-old man developed an extensive osteolytic response to wear debris in an uncemented porous-coated total hip arthroplasty, with metal/polyethylene interface, which had been implanted eighteen years previously. This reaction, which involved the upper femur and the ilium, produced a mass which compressed the pelvic viscera.  (+info)

Circulating biochemical markers of bone remodeling in uremic patients. (4/1036)

Chronic renal failure is often associated with bone disorders, including secondary hyperparathyroidism, aluminum-related low-turnover bone disease, osteomalacia, adynamic osteopathy, osteoporosis, and skeletal beta2-microglobulin amyloid deposits. In spite of the enormous progress made during the last few years in the search of noninvasive methods to assess bone metabolism, the distinction between high- and low-turnover bone diseases in these patients still frequently requires invasive and/or costly procedures such as bone biopsy after double tetracycline labeling, scintigraphic-scan studies, computed tomography, and densitometry. This review is focused on the diagnostic value of several new serum markers of bone metabolism, including bone-specific alkaline phosphatase (bAP), procollagen type I carboxy-terminal extension peptide (PICP), procollagen type I cross-linked carboxy-terminal telopeptide (ICTP), pyridinoline (PYD), osteocalcin, and tartrate-resistant acid phosphatase (TRAP) in patients with chronic renal failure. Most of the observations made by several groups converge to the conclusion that serum bAP is the most sensitive and specific marker to evaluate the degree of bone remodeling in uremic patients. Nonetheless, PYD and osteocalcin, in spite of their retention and accumulation in the serum of renal insufficient patients, are also excellent markers of bone turnover. The future generalized use of these markers, individually or in combination with other methods, will undoubtedly improve the diagnosis and the treatment of the complex renal osteodystrophy.  (+info)

Cladribine activity in adult langerhans-cell histiocytosis. (5/1036)

Langerhans-cell histiocytosis (LCH) results from the accumulation of tissue histiocytes derived from the same progenitor cells as monocytes. Because cladribine is potently toxic to monocytes, we conducted a phase II trial of cladribine. Cladribine was administered to 13 LCH patients at 0.14 mg/kg per day by 2-hour intravenous infusion for 5 consecutive days, every 4 weeks for a maximum of six courses. Median age was 42 years (range, 19 to 72) and median pretreatment disease duration was 99 months (range, 6 to 252). One patient was untreated, one had received prior prednisone only, one prior radiation only, six prior radiation and chemotherapy, and four prior surgery, radiation, and chemotherapy. Seven patients had cutaneous involvement, six multifocal osseous, six pulmonary, two each with soft tissue and nodal involvement, and four had diabetes insipidus. Of 13 patients, 12 were evaluable for response and all for toxicity. After a median of three courses (range, 1 to 6), seven (58%) patients achieved complete responses (two pathologic and five clinical) and two (17%) patients achieved partial responses; overall response rate, 75%. Median response follow-up duration was 33 months (range, 1 to 65). Seven patients experienced grade 3 to 4 neutropenia. Only one patient had a documented infection, dermatomal herpes zoster. At a median follow-up of 42 months (range, 5 to 76), 12 patients remain alive and one patient has died. Thus, cladribine has major activity in adult LCH and warrants further investigation in both pediatric and adult LCH as a single agent and in combination with other drugs.  (+info)

Osteoblast-specific gene expression after transplantation of marrow cells: implications for skeletal gene therapy. (6/1036)

Somatic gene therapies require targeted transfer of the therapeutic gene(s) into stem cells that proliferate and then differentiate and express the gene in a tissue-restricted manner. We have developed an approach for gene therapy using marrow cells that takes advantage of the osteoblast specificity of the osteocalcin promoter to confine expression of chimeric genes to bone. Adherent marrow cells, carrying a reporter gene [chloramphenicol acetyltransferase (CAT)] under the control of a 1.7-kilobase rat osteocalcin gene promoter, were expanded ex vivo. After transplantation by intravenous infusion, engrafted donor cells in recipient mice were detected by the presence of the transgene in a broad spectrum of tissues. However, expression of the transgene was restricted to osteoblasts and osteocytes, as established by biochemical analysis of CAT activity and immunohistochemical analysis of CAT expression at the single cell level. Our data indicate that donor cells achieved long-term engraftment in various tissues of the recipients and that the CAT gene under control of the osteocalcin promoter is expressed specifically in bone. Thus, transplantation of multipotential marrow cells containing the osteocalcin promoter-controlled transgene provides an efficacious approach to deliver therapeutic gene expression to osteoblasts for treatment of bone disorders or tumor metastasis to the skeleton.  (+info)

Beta2-microglobulin and renal bone disease. (7/1036)

Dialysis-related amyloidosis (DRA) is characterized by amyloid deposition mainly in bone and joint structures, presenting as carpal tunnel syndrome, destructive arthropathy, and subchondral bone erosions and cysts. Beta2-microglobulin has been demonstrated to be a major constituent of amyloid fibrils. DRA occurs not only in patients undergoing long-term hemodialysis, but also in patients undergoing continuous ambulatory peritoneal dialysis. The incidence of this complication increases with the duration of dialytic therapy and the age of the patient. While a definitive diagnosis of DRA can be made only by histological findings, various imaging techniques often support diagnosis. The molecular pathogenesis of this complication remains unknown. Recent studies have, however, suggested a pathogenic role of a new modification of beta2-microglobulin in amyloid fibrils--that is, the advanced glycation end-products (AGEs) formed with carbonyl compounds derived from autoxidation of both carbohydrates and lipids ("carbonyl stress"). Therapy for DRA is limited to symptomatic approaches and surgical removal of amyloid deposits. High-flux biocompatible dialysis membranes could be used to delay DRA development.  (+info)

Prostaglandins and bone: physiology and pathophysiology. (8/1036)

Prostaglandins (PGs) are potent stimulators of bone formation and resorption and are produced by bone cells. PGs also have inhibitory effects on fully differentiated osteoblasts and osteoclasts. This complex, multifunctional regulation is probably mediated by different PG receptors. Endogenous PGs in bone are produced largely by induction of COX-2, which is highly regulated by hormones and local factors. The development of specific agonists and antagonists for PG receptors and for COX-2 should allow us to define the physiologic and pathophysiologic roles of PGs more precisely and develop new therapeutic approaches to metabolic and inflammatory disorders of the skeleton.  (+info)

Treatment of Myeloma Bone Disease James R. Berenson, MD Medical & Scientific Director Institute for Bone Cancer & Myeloma Research West Hollywood, CA Clinical Consequences of Myeloma Bone Disease Pathological
We analysed the histological findings in 1146 osteoarthritic femoral heads which would have been considered suitable for bone-bank donation to determine whether pathological lesions, other than osteoarthritis, were present. We found that 91 femoral heads (8%) showed evidence of disease. The most common conditions noted were chondrocalcinosis (63 cases), avascular necrosis (13), osteomas (6) and malignant tumours (one case of low-grade chondrosarcoma and two of well-differentiated lymphocytic lymphoma). There were two with metabolic bone disease (Pagets disease and hyperparathyroid bone disease) and four with inflammatory (rheumatoid-like) arthritis. Our findings indicate that occult pathological conditions are common and it is recommended that histological examination of this regularly used source of bone allograft should be included as part of the screening protocol for bone-bank collection.
Bone disease: Bone disease, any of the diseases or injuries that affect human bones. Diseases and injuries of bones are major causes of abnormalities of the human skeletal system. Although physical injury, causing fracture, dominates over disease, fracture is but one of several common causes of bone disease, and
Bone Diseases Essay, Research Paper Bone diseases most directly influence the ability to walk or to move any part of the body-hands, limbs, neck, and spine. They are
This study will look to see if there are changes in the blood cells that are associated with bone disease and sort out effects that are due to the HIV virus itself, the medications and see if faster aging occurs in the cells of HIV infected persons. Bone disease will be measured by a special X-ray called a DEXA scan. A DEXA scan is used by doctors to see if someone has normal bone mass for their age or if there is thinning of the bones.. The purposes of this study are:. ...
HD Bone Diseases App is simply a source of information about the human musculoskeletal system and some of its diseases/conditions. The facts are well presented in clear sections with eye-catching pictures and pitched at a level which most will find easy to follow. A number of historical facts about conditions are included which makes interesting reading. There is an excellent section on osteoporosis, explaining the cause, investigations and treatments. The other two sections focus on certain bone diseases - these are explained well with lots of detailed information, but the list of conditions covered is far from comprehensive ...
Gum & Bone Disease - Gum and bone disease, otherwise known as periodontal disease, affects over 60 million American adults to some degree every year. Shiley H. Bien, DMD, and
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Journal of Osteoporosis is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working on the diagnosis, prevention, treatment and management of osteoporosis and other metabolic bone diseases. The journal publishes research articles, review articles, as well as clinical studies related to the biology, physiology, and pathology of bone and muscle.
What is bone disease and how does it develop in children? Childhood and adolescence are crucial years for the accrual of minerals necessary for bone health. Appropriate accumulation of these minerals (calcium, phosphorous and magnesium) in the bone help the body reach an optimal peak bone mass in young adulthood and decrease the likelihood of osteoporosis in old age.
So change your daily routine before you have to look for the best orthopedic hospitals in Mumbai.. Injuries: Dont neglect your joint or bone injuries. You may accidentally hurt your knees or joints or otherwise. But even after applying pain relieving cream or ice pack over the area if the pain sustains, then dont waste much time but consult an orthopedic doctor right away.. Diet: Fast food is a big no no if you want to stay healthy in every possible means. You have to have a very healthy and heavy protein rich breakfast. Green leafy vegetables, fish, meat and eggs should be there in your diet. Pulses and nuts should be there as well. Bone diseases are caused due to calcium deficiency. So try to have protein enriched food.. What to do next: If you are having pain in your joints or any bone related problems then do look for orthopedic doctors in the town. Take the help of the internet and research about the doctors and the hospitals they are associated with. In doing so dont stick to one ...
Osteoporosis bone disease literally means bones with holes. It occurs when bones lose minerals such as calcium more quickly than the body can replace them
What is bone disease? Why do people with HIV appear to be especially at risk? What are the signs you might be developing bone problems? In this new ...
Dogs of all ages can limp for a variety of reasons, one being bone disease. With a variety of causes and symptoms, usually associated with appearing sore and tired, it is best to contact your veterinarian for treatment options.
Pathogenesis of Bone Diseases: The Role of Immune System. . Download books free in pdf. Online library with books, university works and thousands of documents available to read online and download.
Learn about the veterinary topic of Noninfectious Skeletal Disorders in Broilers. Find specific details on this topic and related topics from the Merck Vet Manual.
This is your stop for learning resources, extra info and essential dates and documents. Ive scoured the world just to bring you, the A Level biologists, all you need to succeed and enjoy your Biology A Level.
Poor nutrition at any point in a dogs life can lead to chronic conditions like obesity, skeletal diseases and even a shorter life span. In the video
Multiple myeloma is a hematologic malignancy associated with the development of a destructive osteolytic bone disease. Mathematical models are developed for normal bone remodeling and for the dysregulated bone remodeling that occurs in myeloma bone disease. The models examine the critical signaling between osteoclasts (bone resorption) and osteoblasts (bone formation). The interactions of osteoclasts and osteoblasts are modeled as a system of differential equations for these cell populations, which exhibit stable oscillations in the normal case and unstable oscillations in the myeloma case. In the case of untreated myeloma, osteoclasts increase and osteoblasts decrease, with net bone loss as the tumor grows. The therapeutic effects of targeting both myeloma cells and cells of the bone marrow microenvironment on these dynamics are examined. The current model accurately reflects myeloma bone disease and illustrates how treatment approaches may be investigated using such computational approaches. This
The fellowship in Metabolic Bone Disease is a 1 year clinical research program. Successful completion of the program will enable the fellow to evaluate , diagnose and provide evidence based management of complex metabolic bone diseases. These include osteoporosis in pre and postmenopausal women as well as in men, fibrous dysplasia, sclerotic bone diseases, osteomalacia, osteogenesis imperfecta, hypophosphatasia, X-linked hypophosphatemia , renal osteodystrophy and pagets disease. The fellow will also gain competence in evaluating complex calcium and parathyroid disorders as well as an understanding of how and when to complete genetic testing for calcium disorders as well as metabolic bone diseases. The fellow will attend the American Society of Bone and Mineral Research annual scientific meeting and submit research for presentation at this meeting . The fellowship curriculum is outlined in the American Society of Bone and Mineral Research Primer. It is expected that the fellow will be gain this ...
Looking for online definition of uremic bone disease in the Medical Dictionary? uremic bone disease explanation free. What is uremic bone disease? Meaning of uremic bone disease medical term. What does uremic bone disease mean?
Bone disease - Metabolic bone disease: The normal function of bone requires an adequate supply of amino acids (the building blocks for proteins) for the synthesis of collagen, the chief component of the organic matrix; of calcium and phosphate for mineralization of the organic matrix; and of other organic compounds and mineral elements. Also, growth, repair, and remodeling of the bone tissue require a precisely regulated supply of hormones, vitamins, and enzymes. Skeletal disease, when it is due to inadequacies in the supply or action of the above essentials, associated with abnormalities outside the skeleton, is termed metabolic; in such cases the entire skeleton is affected.
TY - JOUR. T1 - A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma. AU - Noonan, Kimberly. AU - Marchionni, Luigi. AU - Anderson, Judy. AU - Pardoll, Drew. AU - Roodman, G. David. AU - Borrello, Ivan. PY - 2010/11/4. Y1 - 2010/11/4. N2 - Osteoclast (OC)-mediated lytic bone disease remains a cause of major morbidity in multiple myeloma. Here we demonstrate the critical role of interleukin-17-producing marrow infiltrating lymphocytes (MILs) in OC activation and development of bone lesions in myeloma patients. Unlike MILs from normal bone marrow, myeloma MILs possess few regulatory T cells (Tregs) and demonstrate an interleukin-17 phenotype that enhances OC activation. In univariate analyses of factors mediating bone destruction, levels of cytokines that selectively induce and maintain the Th17 phenotype tightly correlated with the extent of bone disease in myeloma. In contrast, MILs activated under conditions that skew toward a Th1 phenotype ...
The Metabolic Bone Diseases Clinic at Tufts Medical Center in Boston provides care to manage increased risk for fragility fractures due to bone diseases, like osteoporosis.
The Lawrence Research Competition was established in 2006 to provide seed grants of $45,000 each to two promising investigators in metabolic or metastatic bone disease. Eligible projects include those that study bone metastases, bone health in cancer patients, bone formation, and bone biology. Through mechanisms such as the Rolanette and Berdon Lawrence Bone Research Awards, the Bone Disease Program reaffirms its commitment to fostering groundbreaking research and supporting talented, young investigators in bone research careers ...
ASBMR (2008) Chapter 42. Genetics of Osteoporosis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470623992.ch42 ...
ASBMR (2008) Chapter 9. Animal Models: Allelic Determinants for BMD, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470623992.ch9 ...
Osteoporosis and other bone diseases, such as Pagets disease and osteogenesis imperfecta, can lead to a downward spiral in physical health and quality of life including losing the ability to walk, stand, and dress. It can even lead to premature death. Weak bones can result in painful and debilitating fractures. Each year, 1.5 million Americans suffer a fracture because of weak bones. The most common breaks are of the wrist, spine and hip.. Hip fractures are by far the most devastating type of broken bone and account for almost 300,000 hospitalizations each year. Of hip-fracture patients: 20 percent die within a year of the fracture, and 20 percent end up in a nursing home within a year. Many become isolated, depressed or afraid to leave home because they fear falling.. Bone disease is costly for society and individuals with the disease. In the United States, care for bone fractures from osteoporosis costs nearly $18 billion each year. The cost from a hip fracture for one individual can be more ...
In recent years there has been an increase in the diagnosis of Metabolic Bone disease in hedgehogs and it is a life-threatening syndrome. While the
This finding brings up important questions for further research, said Dr. Brendan Lee, professor of molecular and human genetics at BCM and corresponding author of the report. What happens if you make higher levels of the protein associated with WNT1? Can you use this protein as a biomarker in blood for the status of bone formation?. Lee and his colleagues came to this study with a long history of studying diseases that result in brittle bones. They and others have known for a long time that most families with children who had the genetic brittle bone disease osteogenesis imperfecta (OI) often carry mutations in type I collagen, the most abundant protein in bone.. However, in 2006, their work on families with unknown causes of brittle bone diseases led to the discovery of the first new genes for the disease in over two decades. This has since led to a string of discoveries by them and others on how genes in connective tissues control bone growth. In this, perhaps their most surprising ...
Unless closely monitored, renal bone disease (renal osteodystrophy) is a problem that will be experienced by most people suffering from end stage renal disease (ESRD). Renal bone disease is a complex issue and involves many more factors than can be listed in this limited space. Only the very basics are outlined here. First, the kidneys are involved in the synthesis of vitamin D, which is the most essential factor regulating intestinal absorption of calcium in humans. When the kidneys fail and less vitamin D is created, the amount of calcium absorbed by the intestines is reduced. Calcium is most essential substance for bone maintenance and health. Next, calcium and phosphorus levels in the blood (which are normally regulated by the kidneys) are dependent upon each other. Therefore, when the kidneys fail and the phosphorus level in the blood goes up, the (free) calcium level in the blood decreases. In response to these two factors that lower serum calcium, the body then increases the parathyroid ...
An achy bone. Constipation. Severe thirst. While these symptoms might not seem to have anything in common, they can all signify more serious conditions, including Metastatic Bone Disease (MBD). Many cancers that start in one place can spread (metastasize) to other areas of the body. When it spreads to the bone, its called MBD.MBD occurs…
Symptoms of lytic bone lesions vary since many different diseases can cause them. Typical symptoms include pain, pathologic bone fractures and high blood calcium, according to MedicineNet. Pathologic...
Metastatic bone disease arises from the spread of certain cancers to the skeletal system. The sarcoma care team assesses impending fracture and coordinates care.
Hip dysplasia in Dogs is a Skeletal disease due to the improper fitting of the ball and socket joint in the hip. Check Out The Causes, Symptoms &Treatments.
Cameron TL, Bell KM, Gresshoff IL, Sampurno L, Mullan L, Ermann J, Glimcher LH, Boot-Handford RP, Bateman JF. XBP1-Independent UPR Pathways Suppress C/EBP-ß Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease. PLOS GENETICS 11 (9) : e1005505(2015) PubMed (Grant IDs: 607398 ...
Osteogenesis imperfecta (or brittle bone disease) prevents the body from building strong bones. People with OI have bones that might break easily.
This is the Condition and Disease - Bone Disease page of Green day directory. Submit your Condition and Disease - Bone Disease related sites here, or search for other Condition and Disease - Bone Disease related sites. Browse our Condition and Disease - Bone Disease section with many interesting sites
The method of laser osteoperforation was developed in experiment and then applied for treatment of 508 patients with osteomyelitis, 51 patients with nonunion and pseudo-joint and 34 patients with different forms of osteochondropathy. The clinical trial proved the efficiency of laser osteoperforation for treatment of both inflammatory and destructive bone diseases. This method is minimally invasive, promotes rapid reduction of bone and soft tissue inflammation, and apparently stimulates bone reparation ...
A growth of osteoclasts is inhibited by orally administering a liposomal lactoferrin. Thus a bone disease in which the osteoclast is involved is effectively prevented or treated by orally administerin
Fingerprint Dive into the research topics of Bariatric surgery and bone disease: From clinical perspective to molecular insights. Together they form a unique fingerprint. ...
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OBJECTIVES Identify main functions of bone tissue Identify the major parts of a long bones Describe the cells found in bone tissue Describe the components of an osteon Compare and contrast intramembranous and endochondral ossification.
Dr. Bart Williams is Director of the Center for Cancer and Cell Biology and Professor for the Program in Skeletal Disease and Tumor Microenvironment at the Van Andel Research Institute (VARI).. Dr. Williams research focuses on understanding how alterations in the Wnt signaling pathway cause human disease. A specific focus of his lab is characterizing the role of Wnt signaling in bone formation during normal development and in the face of some common tumor types (for example, prostate, breast, lung, and renal tumors) that metastasize to and grow in bone. The Williams Lab has developed many valuable genetic models of bone disease including osteoarthritis and fracture repair and is working towards identifying novel genes that play key roles in skeletal development and maintenance of bone mass.. Dr. Williams joined VARI as a Scientific Investigator in July 1999. He became a Professor in 2006 and was named Director of the Center for Cancer and Cell Biology in 2010. Dr. Williams was a postdoctoral ...
We move on to Skeletal Disorders and Diseases in dogs in our SlimDoggy Health Check Series. Wikipedia provides a long list of potential issues, we will take a look at the most common. Osteoarthritis:Just as in humans, arthritis is a degenerative disease caused by the deterioration of the cartilage surrounding our
Vanishing bone disease (Gorham-Stout syndrome) is a rare entity of unknown etiology, characterized by destruction of osseous matrix and proliferation of vascular structures, resulting in destruction and absorption of bone. Despite the extensive investigation of the pathogenetic mechanisms of the disease, its etiology hasnt been clarified and several theories exist. The syndrome can affect one or multiple bones of the patient, including the skull, the upper and lower extremities, the spine and pelvis. The clinical presentation of a patient suffering from vanishing bone disease includes, pain, functional impairment and swelling of the affected region, although asymptomatic cases have been reported, as well as cases in which the diagnosis was made after a pathologic fracture ...
A bone with osteoporosis Scientists hope their findings could help to treat common forms of osteoporosis. This photo is taken from BBC.
The U.S. Food and Drug Administration has recently approved an estrogen skin patch that can be worn by post-menopausal women to
To highlight the oral-systemic connection and how your mouth and body are intertwined, Encinitas periodontist Dr. Ann Kania quizzes you on how osteoporosis is linked to your dental health.
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The third edition of Dr. Greenfields book suffers in scope and completeness when compared to two other recent multivolume texts on the same subject. Newer modalities, including nuclear imaging, computed tomography, and angiography, are only briefly discussed. The organization of the text is based on roentgen characteristics and is excellent as are the bibliography and indexing. The quality of many of the illustrations is poor and in some the important information is barely visible. ...
If you have a large or giant breed puppy, you may already be aware that it will not reach its full adult stature until 18 to 24 months. Normal growth spurts of …
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Chapter 15 The locomotor and nervous systems Introduction It is convenient to consider these systems in the same chapter. Although the diseases that affect them may show little or no overlap, there are obvious functional links. This chapter is mainly devoted to the clinical biochemistry of metabolic bone disease, articular disease and muscle disease. Numerous…
Professor Serena Bests Bioactive Materials for Skeletal Repair lecture for the London Materials Society considered degenerative bone disease and how materials research can help
Only 3 months ago I was writing about how surgery cant come soon enough We knew even then there was a risk of surgery failing. We knew my bone disease was behaving erratically and had a mind of its own. Despite the risks of surgery failure we just didnt have a choice. We had to…
Only 3 months ago I was writing about how surgery cant come soon enough We knew even then there was a risk of surgery failing. We knew my bone disease was behaving erratically and had a mind of its own. Despite the risks of surgery failure we just didnt have a choice. We had to…
... a disease that thins and weakens bones, resulting in low bone density and fractures. Estrogen deficiency plays an important ... low estrogen levels increase bone resorption via osteoclasts and osteocytes, cells that help with bone remodeling, making bones ... Office of the Surgeon General (US) (2004). Diseases of Bone. Office of the Surgeon General (US). Alswat KA (May 2017). "Gender ... Estrogen deficiency is also associated with an increased risk of cardiovascular disease, and has been linked to diseases like ...
Glorieux, Francis H.; Pettifor, John M.; Jüppner, Harald (2011). Pediatric Bone: Biology & Diseases. Academic Press. p. 46. ... Bilezikian, John P.; Raisz, Lawrence G.; Martin, T. John Martin (2008). Principles of Bone Biology. Academic Press. p. 610. ...
and other metabolic bone diseases. He has published over 400 scholarly articles and has delivered numerous prestigious ... He is the Director of the Centre for Bone and Periodontal Research and also holds the position of Senior Scientist at the ... He has been Director of the Centre for Advanced Bone and Periodontal Research, as well as Director of the Calcium Research ... He received the Lawrence G. Raisz Award (inaugural) of the American Society for Bone and Mineral Research (ASBMR) in 2010, the ...
Veilleux, Louis-Nicolas; Rauch, Frank (30 August 2017). "Muscle-Bone Interactions in Pediatric Bone Diseases". Current ... In cerebral palsy unequal growth between muscle-tendon units and bone eventually leads to bone and joint deformities. At first ... Adults with cerebral palsy may have ischemic heart disease, cerebrovascular disease, cancer, and trauma more often.[44] Obesity ... People with cerebral palsy are at risk of low bone mineral density.[20] The shafts of the bones are often thin (gracile),[19] ...
3. Versuche an Hunden" [Studies of rickets and related bone diseases. 3. Experiments on dogs]. Archiv für wissenschaftliche und ... This disease was later named Marek's disease. In the birds examined by Marek, the signs of the disease appeared in the nervous ... "Studies of rickets and related bone diseases. 3. Experiments on dogs". CAB Direct. Retrieved December 31, 2019. "Studies on ... Marek is best known for his discovery of the poultry disease that would eventually bear his name, Marek's disease. In his ...
"Nuclear Receptors in Bone Physiology and Diseases". Physiological Reviews. 93 (2): 481-523. doi:10.1152/physrev.00008.2012. ... Deficiencies in nuclear receptor-mediated pathways play a key role in the development of disease, like osteoporosis. Water- ... estrogen deficiency is a cause of osteoporosis and the inability to undergo a proper signaling cascade prevents bone growth and ...
Kidney diseases that are unique to bone marrow transplant (aka Stem Cell Transplant or SCT) are frequently seen in cancer ... Obstructive renal disease 16. Chronic Kidney disease after chemotherapy induced AKI 17. Renal cell cancer 18. CKD following ... Bone marrow transplant related kidney diseases 9. Radiation Nephropathy 10. Tumor Lysis Syndrome 11. Acute Kidney injury in the ... The most common form of kidney disease in cancer patients is acute kidney injury (AKI) which can usually be due to volume ...
SI: Metabolic bone disease. 32 (5): 639-656. doi:10.1016/j.beem.2018.05.006. ISSN 1521-690X. PMID 30449546. Glasdam, Sidsel- ... This can be caused by diabetes insipidus, renal disease, hypothalamic dysfunction, sickle cell disease, and certain drugs. The ... chronic kidney disease, liver disease, treatment with thiazide diuretics, psychogenic polydipsia, syndrome of inappropriate ... Magnesium is mostly found in the bones and within cells. Approximately 1% of total magnesium in the body is found in the blood ...
Other common causes include metabolic bone diseases (e.g. Paget's disease of bone), post-Perthes deformity, osteomyelitis, and ... Coxa vara is also seen in Niemann-Pick disease. Congenital coxa vara[edit]. Presence at birth is extremely rare and associated ... It can also occur when the bone tissue in the neck of the femur is softer than normal, causing it to bend under the weight of ... This may either be congenital or the result of a bone disorder. The most common cause of coxa vara is either congenital or ...
"Bone Mass Measurement: What the Numbers Mean". NIH Osteoporosis and Related Bone Diseases National Resource Center. National ... In bone density measurements, the T-score is the standard score of the measurement compared to the population of healthy 30- ...
Bone diseases and joint problems are also an issue. The most common causes of death in Giant Schnauzers are lymphoma and liver ... They are also prone to skin diseases, such as seasonal flank alopecia, vitiligo, and follicular cysts. Cancer of the skin is ... ISBN 978-0-7566-4978-4. Gough, Alex; Thomas, Alison (2004). Breed Predispositions to Disease in Dogs and Cats. Blackwell ...
Nakashima Y, Okazak K, Nakayama K, Okada S, Mizu-uchi H (January 2017). "Bone and Joint Diseases in Present and Future". ... This technology can also potentially be applied to bone, skin, cartilage and muscle tissue. Though one long-term goal of 3D ... An infant patient with a rare respiratory disease known as tracheobronchomalacia (TBM) was given a tracheal splint that was ... Patients with end-stage bladder disease can be treated by using engineered bladder tissues to rebuild the damaged organ. ...
"Paediatric Immunology, Bone Marrow Transplantation and Infectious Diseases". Newcastle Hospitals. Retrieved 15 April 2018. "The ... The Great North Children's Hospital is one of two units in the UK which perform bone marrow transplants for children who were ...
Wronski TJ, Morey ER (1982-01-01). "Skeletal abnormalities in rats induced by simulated weightlessness". Metabolic Bone Disease ... high-fat diets induces low bone mineral density and reduces bone formation in rats". Journal of Bone and Mineral Research. 25 ( ... Since exercise increases bone quantity, reduces MAT and increases expression of markers of fatty acid oxidation in bone, MAT is ... During aging, bone quantity declines and fat redistributes from subcutaneous to ectopic sites such as bone marrow, muscle, and ...
"An undescribed disease of bone", but he had already been writing on haemochromatosis and he began studying this disease in ... Sheldon, J. H. (January 1929). "An undescribed disease of bone". British Journal of Surgery. 16 (63): 405-430. doi:10.1002/bjs. ... Sheldon, J. H. (July 1938). "Clinical Reports and Demonstrations: Section for the Study of Disease in Children. Arterial ...
"Bone disease in primary hyperparathyrodism". Therapeutic Advances in Musculoskeletal Disease. 4 (5): 357-68. doi:10.1177/ ... Sprenger-Mähr H, Zitt E, Kronbichler A, Cejna M, Lhotta K (November 2019). "A hemodialysis patient with bone disease after ... The osteoclasts consume the trabecular bone that osteoblasts lay down and this front of reparative bone deposition followed by ... it is increasingly rare for primary hyperparathyroidism to present with accompanying bone disease. This is not the case in less ...
... s are particularly common in Paget's disease of bone, and osteopetrosis. It is also seen in cases of fused ... Avioli, Louis V.; Krane, Stephen M. (2013). Metabolic Bone Disease, Volume 2. Academic Press. p. 520. ISBN 9781483267920. Tomar ... Chalkstick fractures are fractures, typically of long bones, in which the fracture is transverse to the long axis of the bone, ... A healthy long bone typically breaks like a hard woody stick as the collagen in the matrix adds remarkable flexibility to the ...
Haidukewych, G. J. (2012). "Metastatic disease around the hip: Maintaining quality of life". Journal of Bone and Joint Surgery ... Republished as: Mirels, Hilton (2003). "The Classic: Metastatic Disease in Long Bones a Proposed Scoring System for Diagnosing ... Gerrand, Craig H.; Rankin, Kenneth (2014). "Metastatic Disease in Long Bones. A Proposed Scoring System for Diagnosing ... Mirels, Hilton (1989). "Metastatic disease in long bones. A proposed scoring system for diagnosing impending pathologic ...
Deficiency results in impaired bone mineralization and bone damage which leads to bone-softening diseases,[26][27] including ... Maternal vitamin D deficiency may cause overt bone disease from before birth and impairment of bone quality after birth.[30][31 ... bone fractures or knee osteoarthritis.[54][55] Low vitamin D levels may result from disease rather than cause disease.[53] ... Bone healthEdit. RicketsEdit. Main article: Rickets. Rickets, a childhood disease, is characterized by impeded growth and soft ...
Dupuytren, Guillaume (1847). On the injuries and diseases of bones. Sydenham Society. Retrieved 7 December 2012.. ... Setting bones[edit]. Examples of healed fractures in prehistoric human bones, suggesting setting and splinting have been found ... Of diseases of the anus. IV. Of the king's evil. V. Of wounds. VI. Of gun-shot wounds. VII. Of fractures and luxations. VIII. ... proposing that diseases have natural causes along with the Four temperaments theory of disease, and leaving the Hippocratic ...
NIH Osteoporosis and Related Bone Diseases National Resource Center". bones.nih.gov. Retrieved 2018-11-07. Konstantinovsky M. " ... "Bones, Muscles, and Joints". kidshealth.org. Retrieved 2018-11-07. "What People With Anorexia Nervosa Need to Know About ... Untreated celiac disease can cause amenorrhea. Reproductive disorders may be the only manifestation of undiagnosed celiac ... A lack of eating causes amenorrhoea and bone loss leading to osteopenia and sometimes progressing to osteoporosis. The social ...
Osteoporosis is a type of bone disease characterized by a loss of bone density, mass and architecture that leaves a patient ... "Osteoporosis Overview , NIH Osteoporosis and Related Bone Diseases National Resource Center". www.bones.nih.gov. Retrieved 2020 ... Exogenous corticosteroids induce osteoporosis by increasing bone resorption and reducing bone formation. Bone loss can be ... Trabecular bone loss in the lumbar spine precedes cortical bone loss in the femoral neck. Allergic: allergic or ...
"Calcium and Vitamin D: Important at Every Age , NIH Osteoporosis and Related Bone Diseases National Resource Center". www.bones ... This can lead to bone weakening and the inability to repair bone damage. Beet pulp is a common ingredient in dog diets as it is ... The reduction of this cushion in the joints causes bone-on-bone contact to occur, causing the animal great discomfort. This can ... This can help aging joints by maintaining the cartilage, thus reducing the pain caused by bone-on-bone contact within the joint ...
ISBN 978-1-4649-6433-6. Bone Diseases: Advances in Research and Treatment: 2011 Edition. ScholarlyEditions. 9 January 2012. p. ... ages 16 to 98 to study the genetic and environmental aetiology of age related complex traits and diseases. Established in 1993 ...
Michou L, Collet C, Laplanche JL, Orcel P, Cornélis F (2006). "Genetics of Paget's disease of bone". Joint Bone Spine. 73 (3): ... "Paget disease of bone: mapping of two loci at 5q35-qter and 5q31". Am. J. Hum. Genet. 69 (3): 528-43. doi:10.1086/322975. PMC ... which cause Paget's disease of bone". Biochem. Soc. Trans. 32 (Pt 5): 728-30. doi:10.1042/BST0320728. PMID 15493999. ... a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. Male and ...
Metabolic Bone Disease and Related Research. 5 (4): 206. doi:10.1016/0221-8747(84)90034-1. ISSN 0221-8747. Frootko, N. J. (1985 ... In 1984 Frootko, working with James Triffitt (now Emeritus Professor of Bone Metabolism in Oxford), was able to demonstrate new ... bone formation in human demineralised allograft ossicles used to reconstruct the ossicular chain. Unfortunately this and all ... using allografts were abandoned in 1987 because of the potential risk of transmission of HIV and Creutzfeldt-Jakob disease from ...
Some malignancies that have spread to involve the bone marrow, such as leukemia or advanced Hodgkin's disease, also cause ... Weiss RB, Brunning RD, Kennedy BJ (December 1975). "Hodgkin's disease in the bone marrow". Cancer. 36 (6): 2077-83. doi:10.1002 ... The SARS disease caused lymphocytopenia. Among patients with laboratory-confirmed COVID-19 in Wuhan China through January 29th ... Faguet GB (October 1975). "Quantitation of immunocompetence in Hodgkin's disease". The Journal of Clinical Investigation. 56 (4 ...
Brickley, Megan; Ives, Rachel (2008). The Bioarchaeology of Metabolic Bone Disease. Burlington: Elsevier. pp. 41-44. ISBN ... The leaves are rich in vitamin C, which cures this deficiency disease resulting from a lack of fresh vegetables in the diet. ... Packer, Lester; Fuchs, Jürgen (1997). Vitamin C in health and disease. New York: M. Dekker. pp. 11-17. ISBN 978-0824793135. ... about a disease suffered by Roman soldiers in Germany. Their symptoms resemble those of scurvy, and Pliny recommends a Herba ...
Fulton loved his work and research, it eventually led to his premature death, as he acquired an unknown disease during one of ... just so many little bones and muscles-so we can only have come from one set of ancestors no matter what our color, the shape of ...
Role in disease[edit]. Plasmacytoma, multiple myeloma, Waldenström macroglobulinemia and plasma cell leukemia are malignant ... Recently they have been shown to reside for much longer periods in the bone marrow as long-lived plasma cells (LLPC). They ... After leaving the bone marrow, the B cell acts as an antigen presenting cell (APC) and internalizes offending antigens, which ... Plasma cells originate in the bone marrow; B cells differentiate into plasma cells that produce antibody molecules closely ...
Nearby were discovered the bones of her dead puppies.. *The University of Notre Dame used an Irish Terrier as its mascot until ... In the 1960s and 1970s there were problems with hyperkeratosis, a disease causing corny pads and severe pain. Today it is ... when an Irish Terrier is very small and light-boned, it loses the correct racy type. ... widely known which dogs carried the disease and respectable breeders do not use those bloodlines any more. A health study ...
Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease. Immunology. May 2016, 148 ( ... bone marrow transplantation, and HIV-1 infection. Annual Review of Immunology. 2000, 18: 529-560. ISSN 0732-0582. PMID 10837068 ... Modulation of autoimmune diseases by interleukin (IL)-17 producing regulatory T helper (Th17) cells. The Indian Journal of ... Immunobiology: the immune system in health and disease 5th ed. New York: Garland Pub. 2001. ISBN 978-0-8153-3642-6. OCLC ...
MacDonald BT, Tamai K, He X (July 2009). "Wnt/β-catenin signaling: components, mechanisms, and diseases". Dev. Cell. 17 (1): 9- ... Coluzzi F, Mandatori I, Mattia C (September 2011). "Emerging therapies in metastatic bone pain". Expert Opin Emerg Drugs. 16 (3 ... may help prevent clinical recurrence of the disease after surgery, but much more work is needed before an adequate treatment ... techniques with therapeutics targeting catenin-associated elements of cancer might be most effective in treating the disease. ...
... trombone], Ray DeGeer [clarinet/sax], Zeb McNally [sax]) ... Infectious disease deaths in Texas. *Songwriters from Texas. * ...
... broken bones and pain. Muscle atrophy results from a co-morbidity of several common diseases, including cancer, AIDS, ... There are many diseases and conditions which cause a decrease in muscle mass, known as atrophy, including activity, as seen ... They would have fewer side-effects, while still promoting muscle and bone tissue growth and regeneration. These claims are, ... Other syndromes or conditions which can induce skeletal muscle atrophy are liver disease, and starvation. Muscle atrophy occurs ...
2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078- ... 2009). "Meningioma 1 gene is differentially expressed in CD34 positive cells from bone marrow of patients with myelodysplastic ...
The disease is often diagnosed 3-6 years after the onset of illness.[19] Several studies have shown that Cushing's disease is ... Cases of Cushing's disease are rare, and little epidemiological data is available on the disease. An 18-year study conducted on ... Cushing disease, tertiary or secondary hypercortisolism, tertiary or secondary hypercorticism, Itsenko-Cushing disease[1][2]. ... The mortality rate of Cushing's disease was reported to be 10-11%,[19][22] with the majority of deaths due to vascular disease[ ...
They have a spine, rib cage, long bones such as the humerus and femur. They also have short bones such as the phalanges, ... The disease is spreading into eastern Panama and threatening all amphibians living there.[27] ... Their heads are strong and have bones that help them dig.[14]p7 Because caecilians have a lot of vertebrae, they can bend ... The bones in amphibians are hollow and do not weigh much.[18] ...
... through the End Stage Renal Disease Program) people of all ages with end-stage renal disease. The Medicare Program provides a ... "The Journal of Bone and Joint Surgery. 100 (3): 236-242. doi:10.2106/JBJS.17.00279. PMID 29406345.. ... chronic obstructive pulmonary disease; and complications of devices, implants and grafts.[78] ...
... coronary heart disease, and cerebrovascular disease, because they ate mostly lean meats and plants and frequently engaged in ... Nelson, D.E., Radiocarbon dating of bone and charcoal from Divje babe I cave, cited by Morley, p. 47 ... Upper Paleolithic (and possibly Middle Paleolithic)[83] humans used flute-like bone pipes as musical instruments,[38][84] and ... In Africa, bone artifacts and the first art appear in the archaeological record. The first evidence of human fishing is also ...
Diseases and parasitesEdit. The black wildebeest is particularly susceptible to anthrax, and rare and widely scattered ... and the wormian bones in the skull.[12] Another study reported an increase in the size of the hybrid as compared to either of ... Malignant catarrhal fever is a fatal disease of domestic cattle caused by a gammaherpesvirus. Like the blue wildebeest, the ... Wild individuals can be competitors of commercial livestock, and can transmit fatal diseases such as rinderpest, and cause ...
This article is about a skin disease common during adolescence. For other acneiform skin diseases, see Acne (disambiguation). ... and decreased bone mineral density, make its use for male acne impractical in most cases.[114][115][116] Pregnant and lactating ... Disease Primers. 1: 15033. doi:10.1038/nrdp.2015.33. PMID 27227877.. *^ a b "Frequently Asked Questions: Acne" (PDF). U.S. ... Acne, also known as acne vulgaris, is a long-term skin disease that occurs when dead skin cells and oil from the skin clog hair ...
"Research Supports Promise of Cell Therapy for Bowel Disease". Wake Forest Baptist Medical Center. 28 February 2013. http://www. ... Bone-marrow Arall. Ffeiliau perthnasol ar Gomin Wicimedia. Mer esgyrn yw'r meinwe hyblyg tu mewn asgwrn. Gyda bodau dynol, mae ... wakehealth.edu/News-Releases/2013/Research_Supports_Promise_of_Cell_Therapy_for_Bowel_Disease.htm. Adalwyd 5 March 2013. ...
Journal of Wildlife Diseases. 42: 81-91. *^ K.R. Rhoades and R.B. Rimler, Avian pasteurellosis, in "Diseases of poultry", ed. ... These often occur in the respiratory tract including the sinuses and pneumatoics bones, hock joints, sternal bursa, foot pads, ... Journal of Wildlife Disease. 42: 33-39. *^ Samuel et al. 2005. Avian Cholera in Waterfowl: The role of Lesser Snow Geese and ... Journal of Wildlife Diseases. *^ Blanchong et al. 2006. Multi-species patterns of avian cholera mortality in Nebraska's ...
SP concentrations cannot yet be used to diagnose disease clinically or gauge disease severity. It is not yet known whether ... "Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow ... Microbial Toxins and Diarrhoeal Disease. Ciba Found. Symp. 112. pp. 139-54. doi:10.1002/9780470720936.ch8. PMID 2861068.. ... Quantification in diseaseEdit. Elevation of serum, plasma, or tissue SP and/or its receptor (NK1R) has been associated with ...
The first physician to perform a successful human bone marrow transplant on a disease other than cancer was Robert A. Good at ... Graft-versus-host disease[edit]. Main article: Graft-versus-host disease. Graft-versus-host disease (GVHD) is an inflammatory ... "Bone Marrow Transplant" redirects here. For the journal abbreviated Bone Marrow Transplant, see Bone Marrow Transplantation ( ... Veno-occlusive disease[edit]. Severe liver injury can result from hepatic veno-occlusive disease (VOD). Elevated levels of ...
Mandel SJ, Brent GA, Larsen PR (September 1993). "Levothyroxine therapy in patients with thyroid disease". Annals of Internal ... suppression of TSH values below normal values will frequently cause cardiac side-effects and contribute to decreases in bone ... For older people (over 50 years old) and people with known or suspected ischemic heart disease, levothyroxine therapy should ... Levothyroxine is also used as interventional therapy in people with nodular thyroid disease or thyroid cancer to suppress ...
"Bone Marrow Res 2012: 787414. PMC 3398573. PMID 22830032. *↑ William JB; Prabakaran, Rajamanickam; Ayyappan, Subbu (2011). " ... Lindvall O (2003). "Stem cells for cell therapy in Parkinson's disease". Pharmacol Res 47 (4): 279-87. PMID 12644384. ... 2006). "Improved liver function in patients with liver cirrhosis after autologous bone marrow cell infusion therapy". Stem ... "P-Selectin coated microtube for enrichment of CD34+ hematopoietic stem and progenitor cells from human bone marrow". Clin Chem ...
"Journal of Bone and Mineral Research. 22 (8): 1245-1259. doi:10.1359/jbmr.070420. PMID 17456009.. ... The results of this research was used as a model for Kashin-Beck disease. Kashin-Beck is a result of combinatorial ... giving rise to either bone or cartilage respectively. Osteochondroprogenitor cells are important for bone formation and ... Brian Keith Hall (2005). Bones and cartilage: developmental and evolutionary skeletal biology. Academic Press. pp. 150-. ISBN ...
By 1682, when William Penn arrived to his American commonwealth, the Lenape had been so reduced by disease, famine, and war ... beating thigh bones on their palms to drive animals to the river, where they could be killed easily. Other methods of hunting ... as the diseases had arisen on the Asian continent and moved west into Europe, where they had become endemic in the cities. ... due to high fatalities from epidemics of infectious diseases carried by Europeans, such as measles and smallpox, to which they ...
The disease is most common in native laborers and in schoolchildren of the tropics and subtropics during the rainy season and ... Deep tissue invasion: Often with bone involvement, and potentially leading to amputation.[citation needed] Chronic ulceration.[ ... In some of these countries, such as northern Papua New Guinea, it is the most common skin disease. It is also a frequent ... Tropical ulcer has been described as a disease of the 'poor and hungry'; it may be that slowly improving socioeconomic ...
Normally, the bone age is the same as the biological age but for some people, it is older. For many people with advanced bone ... chronic kidney disease, being small for gestational age at birth, Prader-Willi syndrome, Wiedemann-Steiner syndrome, or other ... When the cause is unknown, it is called idiopathic short stature.[5] Short stature can also be caused by the bone plates fusing ... However, in some cases, people who are naturally shorter combined with their advanced bone age, end up being even shorter than ...
The organization hosts events throughout the year to support the hematology/oncology/bone marrow transplant unit[71] at ... a research institute for cardiovascular disease. ...
Manuel Bandeira, Brazilian poet, had TB in 1904 and expressed the effects of the disease in his life in many of his poems. ... Elizabeth of Austria (1436-1505), a study of her bones indicated that she had probably tuberculosis at a young age. ... He was rumored to have discovered his disease when he coughed blood and fainted during the Ikedaya Affair. ... and ultimately died of the disease days after a New York City recording session. ...
A gorge was a long, thin piece of bone or stone attached by its midpoint to a thin line. The gorge would be baited so that it ... DNR Fishing Regulation Changes Reflect Disease Management Concerns with VHS Archived 2008-12-14 at the Wayback Machine ... In 2007, several American states, enacted regulations designed to slow the spread of fish diseases, including viral hemorrhagic ... septicemia, by bait fish.[1] Because of the risk of transmitting Myxobolus cerebralis (whirling disease), trout and salmon ...
... subluxation is the sole cause of disease and manipulation is the cure for all diseases of the human race.[4][41] A 2003 ... Chiropractors use x-ray radiography to examine the bone structure of a patient. ... Palmer, a magnetic healer, hypothesized that manual manipulation of the spine could cure disease.[214] The first chiropractic ... A subluxated vertebra ... is the cause of 95 percent of all diseases ... The other five percent is caused by displaced joints ...
Significant diseases. Cancer, bone fractures. Significant tests. screening tests, X-ray, CT, MRI, PET, bone scan, ... DEXA, or bone densitometry, is used primarily for osteoporosis tests. It is not projection radiography, as the X-rays are ... Usually the hip (head of the femur), lower back (lumbar spine), or heel (calcaneum) are imaged, and the bone density (amount of ... This is the standard method for bone densitometry. It is also used in CT pulmonary angiography to decrease the required dose of ...
Disease has to be very virulent to kill off all the individuals in a genus or species, and even such a virulent disease as West ... Reconstructed woolly mammoth bone hut, based on finds in Mezhyrich.. The passenger pigeon was a species of pigeon endemic to ... DiseaseEdit. The hyperdisease hypothesis, proposed by Ross MacPhee in 1997, states that the megafaunal die-off was due to an ... DiseaseEdit. See also: Decline in amphibian populations, White nose syndrome, Colony collapse disorder, and Pesticide toxicity ...
Learn about different kinds of bone problems and how genetics can play a role. ... Bone diseases increase your risk for breaking bones. ... Pagets disease of bone makes them weak *Bones can also develop ... Bone diseases can make bones easy to break. Different kinds of bone problems include ... After about age 20, you can lose bone faster than you make bone. To have strong bones when you are young, and to prevent bone ...
Health Information on Bone Diseases: MedlinePlus Multiple Languages Collection ... Bone Diseases: MedlinePlus Health Topic - English Enfermedades de los huesos: Tema de salud de MedlinePlus - español (Spanish) ... Kids and Their Bones: A Guide for Parents - English HTML Kids and Their Bones: A Guide for Parents - español (Spanish) HTML ... Kids and Their Bones: A Guide for Parents - English HTML Kids and Their Bones: A Guide for Parents - 简体中文 (Chinese, Simplified ...
Other diseases and disorders of the bone marrow. Other diseases and disorders of the bone marrow include:. * Disorders of ... Metabolic bone disease etc.. * Bone marrow depression may be caused due to cancer chemotherapy, bone marrow transplantation and ... Main bone marrow problems. Diseases of the bone marrow may lead to an abnormality in the production of any of the mature blood ... "Myelo" means bone marrow and MPD signifies proliferation of the bone marrow. These are a group of diseases. ...
Bone and Joint Diseases. Br Med J 1952; 2 doi: https://doi.org/10.1136/bmj.2.4779.325-a (Published 09 August 1952) Cite this as ...
... and does not spread from bone to bone. Rarely, a bone affected by Pagets disease can transform into a malignant bone cancer. ... Ethel, SS; Roodman, GD (2008). "Pagets disease of bone". In Rosen. Primer on the metabolic bone diseases and disorders of ... Pagets Disease of Bone Overview - NIH Osteoporosis and Related Bone Diseases ~ National Resource Center. ... Bone scans are useful in determining the extent and activity of the condition. If a bone scan suggests Pagets disease, the ...
Bone disease - Fractures: A fracture occurs when the bone tissue is subjected to tensile, compressive, or shear forces in ... Both the strength of the bone tissue and the nature of the forces acting on bone change from infancy to old age, both normally ... The bone tissue in young adults has high resistance to mechanical deformation. Fractures of cortical bone in adults require ... and as a result of disease. Therefore, the incidence and type of fractures change with age. ...
Bone disease, any of the diseases or injuries that affect human bones. Diseases and injuries of bones are major causes of ... Although physical injury, causing fracture, dominates over disease, fracture is but one of several common causes of bone ... Bone disease, any of the diseases or injuries that affect human bones. Diseases and injuries of bones are major causes of ... fracture is but one of several common causes of bone disease, and disease is in fact a common cause of fracture. Bone diseases ...
Bone Disease Br Med J 1966; 2 :817 doi:10.1136/bmj.2.5517.817-c ... Bone Disease. Br Med J 1966; 2 doi: https://doi.org/10.1136/bmj ...
... affects women and men of all ethnicities, although the risk of bone disease is highest among women. Bone disease ... Bone disease is a condition that damages the skeleton and makes bones weak and prone to fractures. Weak bones are not a natural ... Bone disease is costly for society and individuals with the disease. In the United States, care for bone fractures from ... The most common bone disease is osteoporosis, which is characterized by low bone mass and deterioration of bone structure. ...
Bone infections and inflammations are among the most common and important indications for bone scintigraphy, the sensitivity of ... Infective and Infl ammatory Diseases of Bone. In: Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases ... Jones DC, Cady RB (1981) "Cold" bone scans in acute osteomyelitis. J Bone Joint Surg Br 63:376-378 PubMedGoogle Scholar ... Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases pp 75-106 , Cite as ...
... Giorgio Mori,1 Patrizia DAmelio,2 Roberta Faccio,3 and Giacomina Brunetti4 ... Glucocorticoid-induced bone disease," The New England Journal of Medicine, vol. 365, pp. 62-70, 2011. View at Google Scholar ... G. D. Roodman, "Pathogenesis of myeloma bone disease," Leukemia, vol. 23, no. 3, pp. 435-441, 2009. View at Publisher · View at ... A. C. Monteiro, A. C. Leal, T. Gonçalves-Silva et al., "T cells induce pre-metastatic osteolytic disease and help bone ...
PAIN Leaflet Brittle Bone DiseaseThe child with unexplained fractures By Dr Colin R Paterson, Department ofMedicine, University ... Pain leaflet brittle bone disease * 1. PAIN Leaflet Brittle Bone DiseaseThe child with unexplained fractures By Dr Colin R ... However, unexplained fractures in childhood are also the hallmark ofall forms of brittle bone disease and immense harm can be ... There are four principal types of evidence that support the view that temporary brittle bone disease exists and does not ...
Information on Pagets disease of the bone for patients and caregivers, such as: what it is, common symptoms, getting diagnosed ... Pagets disease typically occurs in an older population.. *Signs of Pagets disease of bone include: pain associated with bones ... What is Pagets disease?. Normally, as people age, their bones rebuild at a slower rate. For those with Pagets disease, ... Pagets disease of bone is an uncommon, chronic bone disorder that occurs in only about one percent of people in the United ...
Metabolic bone disease. Definition. Metabolic bone disease describes a diverse group of disorders of bone metabolism, most ... Mass spectrometric quantitation of AGEs and enzymatic crosslinks in human cancellous bone *Shoutaro Arakawa ... Anabolic agents represent a novel approach to improving bone quality in people with osteoporosis. This Review discusses ...
Bone diseases are disorders and conditions that cause abnormal development and/or impairment in normal bone development. This ... Paget Disease of Bone. Paget disease of bone (PDB) is the second most common bone remodeling disease after osteoporosis. PDB ... Your bones undergo remodeling throughout life wherein old bone is removed and replaced by new bone. Bone diseases affect normal ... ":"[top bone disorders,common bone diseases,osteoporosis,Paget disease of bone,osteomyelitis,osteogenesis ...
Nutritional experts have released guidelines on how to improve bone health in a bid to reverse the rapid increase in cases of ... Teenage girls with a history of eating disorders have developed the bone-wasting disease osteoporosis, according to the ... The most important time to ensure calcium and vitamin D levels are adequate is while the bones are being formed. The NOS has ... Osteoporosis, which leads to bone fractures, is caused by lack of calcium, regular exercise and vitamin D. Experts predict the ...
... as well as diseases such as osteoporosis and Pagets disease of bone that damage the skeleton later in life. In addition to ... This chapter reviews some of the more common diseases, disorders, and conditions that both directly and indirectly affect bone. ... can be disrupted in different ways that result in a variety of bone diseases and disorders. These include problems that can ... conditions that affect bone directly, there are many other disorders that indirectly affect bone by interfering with mineral ...
Psoriatic disease--from skin to bone.. Ritchlin C1.. Author information. 1. University of Rochester School of Medicine and ... Evidence that this disease is distinct from rheumatoid arthritis and other spondyloarthropathies is based on data derived from ... A new terminology, psoriatic disease, has emerged that encompasses the various manifestations of tissue and organ involvement ... Psoriatic arthritis is an inflammatory joint disease that is heterogeneous in presentation and clinical course. ...
Biomarkers in bone disease. [Victor R Preedy;] -- In the past decade there has been a major sea change in the way disease is ... activity and disease severity to determine secular changes in bone disease as applied to Paget\s disease of the bone -- Bone ... activity and disease severity to determine secular changes in bone disease as applied to Pagets disease of the bone --. Bone ... Circulating Sclerostin in Bone Sclerosing Disorders --. Pentraxin 3 as a bone biomarker --. Sirtuins as markers of bone disease ...
... prevents the body from building strong bones. People with OI have bones that might break easily. ... This makes their bones weaker and more brittle than normal bones. It can also lead to bone deformities. (Deformed bones do not ... People with OI might have bones that break easily, which is why the condition is commonly called brittle bone disease. ... Preventing Broken Bones. Preventing bone fractures is key for people with OI. They can lower their risk of broken bones by:. * ...
Aluminum bone disease. Insidious appearance of bone pain, fractures, proximal muscle weakness (diagnosis by bone biopsy; ... Guideline 8: Vitamin D Therapy in Patients with Chronic Kidney Disease. *Guideline 13: Treatment of Bone Disease in Chronic ... Guideline 8: Vitamin D Therapy in Patients with Chronic Kidney Disease. *Guideline 13: Treatment of Bone Disease in Chronic ... Cite this: Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease: An Overview - Medscape - Dec ...
Antisense inhibition of macrophage inflammatory protein 1-alpha blks bone destruction in a model of MM bone disease J Clin ... Multiple Myeloma Bone Marrow Stromal Cell Bone Destruction Adenomatous Polyposis Coli Gene Bone Marrow Plasma These keywords ... bone disease has been omitted from recent staging schema.4 Nonetheless, bone destruction remains a major source of morbidity.5 ... Mechanisms of disease: mechanisms of bone metastasis. N Engl J Med 2004; 350:1655-1664.PubMedCrossRefGoogle Scholar ...
... and University Childrens Hospital Zurich have discovered the first X-chromosome-inherited type of the congenital disease ... also known as brittle-bone disease. The new discovery improves the genetic diagnosis of the disease and paves the way to ... The culprit is a change in the bone metabolism, which no longer seems to be impaired in the case of dermatological diseases. ... Between 300 and 400 people in Switzerland and around half a million worldwide suffer from brittle-bone disease, which causes ...
Im experiencing an intermittent dull pain in the center of my chest that feels like its coming from my breast bone as opposed ... Can Mental Stress Lead to Heart Disease? Can depression and anxiety cause heart disease? Get the facts in this Missouri ... Heart Disease Forum This expert forum is not accepting new questions. Please post your question in one of our medical support ... Im experiencing an intermittent dull pain in the center of my chest that feels like its coming from my breast bone as opposed ...
For about a week now Ive noticed unusual pain in between my breasts as if the pain is located on the bone. It becomes painful ... Breast Bone Pain. For about a week now Ive noticed unusual pain in between my breasts as if the pain is located on the bone. ... Can Mental Stress Lead to Heart Disease? Can depression and anxiety cause heart disease? Get the facts in this Missouri ... Breast Bone Pain Kimmy600 For about a week now Ive noticed unusual pain in between my breasts as if the pain is located on the ...
Rabbit with broken calcaneal tuber (pelvic limb) and possible bacterial joint infection, radiography and explanation, by Debbie Hanson. In collaboration with Dr. Dan Jordan and the rabbit Parker ...
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The weak tendons and fragile bones characteristic of osteogenesis imperfecta, or brittle bone disease, stem from a genetic ... Brittle bone disease affects about one in 16,000 people worldwide, and defective collagen is implicated in many other medical ... The different forms of severity in brittle bone disease correlate with a particular genetic mutation; some amino acid ... The broader category of protein-based diseases contains even neuronal disorders such as Alzheimers disease.. Three years ago, ...
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  • Fractures of cortical bone in adults require tremendous forces, such as those encountered in motor accidents, and are therefore often associated with severe skin injuries and other lesions of soft tissue. (britannica.com)
  • Angular deformation of long bones in children therefore often results in incomplete, or "greenstick," fractures. (britannica.com)
  • In adults age 20 to 50, fractures are often caused by direct high-energy forces that have an explosive effect on bone and soft tissues and may cause severely displaced open fractures. (britannica.com)
  • Such fractures are rarely associated with soft tissue injury and often involve cancellous rather than cortical bone. (britannica.com)
  • The skin wound in open fractures is caused either by severe direct trauma or by a sharp bone fragment that pierces the skin from within. (britannica.com)
  • Fatigue, or stress , fractures occur because the bone tissue is exposed to forces that overwhelm its capacity for structural adaptation . (britannica.com)
  • Stress fractures usually produce pain even before bone abnormality can be seen by X-ray. (britannica.com)
  • Fractures that occur because of preexisting disease are called pathologic fractures. (britannica.com)
  • Certain fractures injure the nutrient blood vessels of the bone tissue, with osteonecrosis as a result. (britannica.com)
  • In adults, an extremity affected by nerve injury gradually develops osteopenia (a reduced amount of bone tissue), so that it fractures easily. (britannica.com)
  • Bone disease is a condition that damages the skeleton and makes bones weak and prone to fractures. (news-medical.net)
  • Fractures to weak bones typically occur from falling or other common accidents. (news-medical.net)
  • Paget's disease affects older men and women, and causes skeletal deformities and fractures. (news-medical.net)
  • Osteogenesis imperfecta is an inherited disorder that causes brittle bones and frequent fractures in children. (news-medical.net)
  • Weak bones can result in painful and debilitating fractures. (news-medical.net)
  • Hip fractures are by far the most devastating type of broken bone and account for almost 300,000 hospitalizations each year. (news-medical.net)
  • In the United States, care for bone fractures from osteoporosis costs nearly $18 billion each year. (news-medical.net)
  • Osteoporosis is a silent disease until fractures occur. (news-medical.net)
  • However, unexplained fractures in childhood are also the hallmark ofall forms of brittle bone disease and immense harm can be done to families by the inaccuratediagnosis of non-accidental injury.Much of our research over the last 25 years has related to the clinical aspects of the brittle bonediseases and we hold a database with details of over 1,300 patients. (slideshare.net)
  • Since collagen is abnormal in tissues other than bone,patients with osteogenesis imperfecta now have detectable features in addition fractures. (slideshare.net)
  • The fracture pattern is often distinctive with rib fractures and fractures at the endsof long bones (metaphyseal fractures) being frequent. (slideshare.net)
  • This causes bone fragility and an increased risk for fractures. (livestrong.com)
  • Bone disease in multiple myeloma (MM) is characterized by lytic bone lesions, which can cause severe bone pain, pathologic fractures and hypercalcemia. (nih.gov)
  • Osteoporosis, which leads to bone fractures, is caused by lack of calcium, regular exercise and vitamin D. (bbc.co.uk)
  • Type IV osteogenesis imperfecta - people with type IV OI can have mild to serious bone deformities, short stature, frequent fractures (which may lessen after puberty), and a curved spine. (kidshealth.org)
  • Besides a family history of OI, doctors look for frequent or unexplained bone fractures, dental problems, blue sclera (the white part of the eye), short stature, and other symptoms as signs that a child has OI. (kidshealth.org)
  • In severe cases, prenatal testing (such as an ultrasound ) can detect fractures and bone deformities before a baby is born. (kidshealth.org)
  • The goal is to prevent fractures, treat them properly when they do happen, preserve mobility and independence, and strengthen bones and muscles. (kidshealth.org)
  • Preventing bone fractures is key for people with OI. (kidshealth.org)
  • These lytic lesions are responsible for many of the clinical sequelae of progressive disease, including pathologic fractures, severe pain, and hypercalcemia. (springer.com)
  • One of Mother Nature's latest gifts to medical science is stirring excitement with the discovery that the substance obtained from a coral-reef inhabiting cyanobacterium appears to be an ideal blueprint for developing new drugs for serious fractures, osteoporosis, and other bone diseases. (medindia.net)
  • Osteoporosis makes the bones more fragile and the fractures occur most commonly in the vertebral column, rib, hip and wrist. (medindia.net)
  • Disruptions to this balance occur in multiple myeloma, where cancerous blood cells crowd the bone marrow , and in bone-metastatic tumors, which lead to chronic bone pain and fractures . (medicalnewstoday.com)
  • Bone fractures may also occur. (rxlist.com)
  • This will let your doctor watch for other problems you might get from the disease, such as arthritis, fractures, or nerve problems. (healthlinkbc.ca)
  • Medicine can help reduce the breakdown of bone tissue, control symptoms such as bone pain, and prevent other problems such as arthritis, fractures, or nerve damage. (healthlinkbc.ca)
  • To find out if you are suffering from bone disease, ask your doctor to conduct blood tests to screen your levels of calcium, phosphorous and vitamin D. Low levels can contribute to unhealthy bones and fractures. (thebody.com)
  • This study evaluated the incidence of major osteoporotic fractures (hip, spine, forearm and humerus) in patients with celiac disease confirmed by a positive celiac profile on blood testing, and compared the risk of fracture with those who did not have celiac disease. (osteoporosis.ca)
  • Individuals with celiac disease had more fractures in comparison to those who did not have celiac disease (HR 1.43 (95% CI 1.11-1.86)) (1). (osteoporosis.ca)
  • This study showed that people with celiac disease had more fractures than expected if the celiac disease had not been present. (osteoporosis.ca)
  • Heikkilä K, Pearce J, Mäki M and Kaukinen K. Celiac disease and bone fractures: A systematic review and meta-analysis. (osteoporosis.ca)
  • And because the abnormal bone is weaker and more brittle than normal, it is prone to fractures. (mydr.com.au)
  • Myeloma bone disease can result not only in fractures, but in pressure on the spinal cord (spinal cord compression), the need for surgery to prevent or repair broken bones, and/or the need for radiation treatments to the bone to control the myeloma and relieve pain. (myeloma.org)
  • The result is too much bone breakdown and too little bone build-up: the bones are weakened, leading to lytic lesions, which in turn can lead to pathologic fractures. (myeloma.org)
  • We specifically focus on trauma including bone fractures, but also the diseases rickets and leprosy. (coursera.org)
  • Vitamin D deficiency was associated with cortical bone loss and severity of fractures in elderly patients with prevalent fractures. (greenmedinfo.com)
  • The low levels of phosphate in the blood can cause rickets, which can then lead to bone deformities, decreased height, and a greater risk of fractures. (xconomy.com)
  • Once the doctors know more about your condition, they will work closely with you to develop a customized treatment plan to optimize bone mass and in turn, reduce fractures and prevent complications. (tuftsmedicalcenter.org)
  • Osteoclasts are cells of a hematopoetic lineage that resorb bone, and excessive activity of these cells can lead to low bone mass with an associated increased incidence of fractures. (sciencemag.org)
  • Increased osteolysis is a common feature of inflammatory disorders and a risk factor for bone fractures. (springer.com)
  • People with OI are vulnerable to frequent bone fractures, brittle teeth, loose ligaments, muscle weakness, hearing loss, spinal curvature and skeletal dysplasia . (hss.edu)
  • Paget's disease is not associated with osteoporosis. (wikipedia.org)
  • Although Paget's disease and osteoporosis can occur in the same patient, they are different disorders. (wikipedia.org)
  • Despite their marked differences, several treatments for Paget's disease are also used to treat osteoporosis. (wikipedia.org)
  • The most common bone disease is osteoporosis, which is characterized by low bone mass and deterioration of bone structure. (news-medical.net)
  • Osteoporosis and other bone diseases, such as Paget's disease and osteogenesis imperfecta, can lead to a downward spiral in physical health and quality of life including losing the ability to walk, stand, and dress. (news-medical.net)
  • Four times as many men and nearly three times as many women have osteoporosis than report having the disease. (news-medical.net)
  • Treatment of osteoporosis in children with glucocorticoid-treated diseases," Expert Review of Endocrinology & Metabolism , vol. 9, no. 5, pp. 525-534, 2014. (hindawi.com)
  • Anabolic agents represent a novel approach to improving bone quality in people with osteoporosis. (nature.com)
  • Osteoporosis is characterized by an abnormal loss of bone mass and deterioration of normal bone structure. (livestrong.com)
  • According to a November 2014 study published in the " Journal of Bone and Mineral Research ," 10.3 percent of US adults aged 50 or older have osteoporosis and 43.9 percent have low bone mass. (livestrong.com)
  • Medications called bisphosphonates help preserve bone mass in people with osteoporosis. (livestrong.com)
  • Paget disease of bone (PDB) is the second most common bone remodeling disease after osteoporosis. (livestrong.com)
  • Teenage girls with a history of eating disorders have developed the bone-wasting disease osteoporosis, according to the National Osteoporosis Society. (bbc.co.uk)
  • Bone Health and Osteoporosis: A Report of the Surgeon General. (nih.gov)
  • This bone loss can be minimized and osteoporosis prevented through adequate nutrition, physical activity, and, if necessary, appropriate treatment. (nih.gov)
  • There are a wide variety of diseases and certain medications and toxic agents that can cause or contribute to the development of osteoporosis. (nih.gov)
  • If recognized as a potential threat, this form of the disease-known as secondary osteoporosis-can often be prevented through proper nutrition and physical activity, along with appropriate therapy if needed. (nih.gov)
  • These include problems that can occur at or before birth, such as genetic abnormalities and developmental defects, as well as diseases such as osteoporosis and Paget's disease of bone that damage the skeleton later in life. (nih.gov)
  • As pointed out in Chapter 2 , osteoporosis is a disease characterized by low bone mass and deterioration of bone structure that causes bone fragility and increases the risk of fracture. (nih.gov)
  • For practical purposes, the World Health Organization has defined osteoporosis as a bone mineral density ( BMD ) value more than 2.5 standard deviations below the mean for normal young White women. (nih.gov)
  • Osteoporosis is a common disease affecting millions of Americans. (nih.gov)
  • Generalized osteoporosis is the most common form of the disease, affecting most of the skeleton. (nih.gov)
  • Osteoporosis can also occur in localized parts of the skeleton as a result of injury or conditions that reduce muscle forces on the bone, such as limb paralysis. (nih.gov)
  • Bone loss caused by specific diseases or medications (see below) is referred to as "secondary osteoporosis. (nih.gov)
  • Osteoporosis in lung transplantation candidates with end-stage pulmonary disease. (washington.edu)
  • When women reach menopause bone loss can accelerate and cause osteoporosis because estrogen, which helps their bones to absorb calcium, begins to decline. (medindia.net)
  • Most people are aware of the foods which promote bone health but are unaware of those that lower bone density leading to osteoporosis. (medindia.net)
  • Osteoporosis is a disease that causes bones to become thinner, more porous and break more easily. (npr.org)
  • The disease is the most common bone disorder after osteoporosis in adults older than age 50. (hopkinsmedicine.org)
  • Scientists have developed an approach to creating treatments for osteoporosis and autoimmune diseases that may avoid the risk of infection and cancer posed by some current medications. (eurekalert.org)
  • Frankel BM, Jones T, Wang C. Segmental polymethylmethacrylate-augmented pedicle screw fixation in patients with bone softening caused by osteoporosis and metastatic tumor involvement: a clinical evaluation. (medscape.com)
  • Three types of bone disease tend to be most common among people with HIV: osteopenia, osteoporosis and osteonecrosis . (thebody.com)
  • Osteoporosis occurs when the bones are broken down more rapidly than they are replaced. (thebody.com)
  • If the bone mineral density data is entered into the calculator, it does not incorporate the presence of another cause for the osteoporosis (such as celiac disease) in determining the fracture risk. (osteoporosis.ca)
  • The Scientific Advisory Council (SAC) is made up of experts in Osteoporosis and bone metabolism and is a volunteer membership. (osteoporosis.ca)
  • Myeloma bone disease can cause the bones to become thinner and weaker (osteoporosis), and it can make holes appear in the bone (lytic lesions). (myeloma.org)
  • Osteoporosis in general population as well as patients with chronic kidney disease. (sgh.com.sg)
  • A bone with osteoporosis Scientists hope their findings could help to treat common forms of osteoporosis. (thedailystar.net)
  • As we understand more about bone turnover and communication between bone cells, work could open doors for future research that could affect osteoporosis. (thedailystar.net)
  • The Metabolic Bone Diseases Clinic at Tufts Medical Center provides cutting edge care to patients with osteoporosis, hyperparathyroidism, and other conditions that weaken bones. (tuftsmedicalcenter.org)
  • Each fellow will cover the monthly Metabolic Bone Disease Clinic, the weekly Metabolic Bone Disease Conference and the weekly Osteoporosis Patient sign-out. (hss.edu)
  • The disease, osteoporosis, is aggravated by a lack of calcium and it causes deterioration in bone strength and resiliency. (orlandosentinel.com)
  • Cherry says, "This study suggest that women who take steps early in life to keep their bones strong, or boost their bone density once weakness appears, may not only prevent osteoporosis but may prevent heart disease as well. (charismamag.com)
  • osteoporosis osteomalacia (adults) & rickets (children) osteitis fibrosa cystica Paget's disease of bone pyramiding (turtles) Osteoporosis is due to causal factors like atrophy of disuse and gonadal deficiency. (wikipedia.org)
  • The diseases and disorders of the bone marrow include Leukemia, Myelodysplastic Syndrome, Myeloproliferative disorders and so forth. (news-medical.net)
  • Paget's disease often causes an arthritic condition and can be diagnosed and treated by your rheumatologist as well as medical care practitioners who focus on bone disorders. (rheumatology.org)
  • Metabolic bone disease describes a diverse group of disorders of bone metabolism, most commonly caused by abnormalities of minerals (such as calcium or phosphorous) or vitamin D. (nature.com)
  • These diseases affect children and adults and occur due to genetic abnormalities, nutritional deficiencies, hormonal disorders, infections and other conditions. (livestrong.com)
  • One of the most common of these acquired skeletal disorders is a malignancy of the bone. (nih.gov)
  • The body systems that control the growth and maintenance of the skeleton, which are described in Chapter 2 , can be disrupted in different ways that result in a variety of bone diseases and disorders. (nih.gov)
  • In addition to conditions that affect bone directly, there are many other disorders that indirectly affect bone by interfering with mineral metabolism. (nih.gov)
  • This chapter reviews some of the more common diseases, disorders, and conditions that both directly and indirectly affect bone. (nih.gov)
  • These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. (worldcat.org)
  • The consideration of how material properties change in diseases could lead to a new paradigm in the study of genetic disorders that expands beyond the biochemical approach," said Buehler. (redorbit.com)
  • The broader category of protein-based diseases contains even neuronal disorders such as Alzheimer's disease. (redorbit.com)
  • The symptoms of Paget disease of the bone may look like other bone disorders or medical problems. (hopkinsmedicine.org)
  • Early indications also show that the disorders of the gut could potentially be treated through the bone marrow, says Pam Fraker, Michigan State University professor of biochemistry and molecular biology. (futurity.org)
  • bone diseases or disorders, list or types of bone diseases, homeopathy medicine, and homeopathic treatment for bone diseases. (hpathy.com)
  • Current treatments for bone loss and autoimmune disorders block these molecules and their signals indiscriminately, which over time increases the risk of infections and cancer. (eurekalert.org)
  • Bone disease is a very general term that describes a wide variety of bone disorders that affect the structure of the bone and/or the strength of the cells that it comprises. (thebody.com)
  • The authoritative reference to bone diseases and disorders of mineral metabolism, revised and update. (wiley-vch.de)
  • Now in its ninth edition, The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone and mineral health. (wiley-vch.de)
  • The ninth edition provides concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. (wiley-vch.de)
  • The new edition of this invaluable reference expands coverage and includes the most recent developments in the field that help to strengthen its usefulness and ensure that the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism maintains its place as the pre-eminent reference on bone and mineral health. (wiley-vch.de)
  • Written for advanced students, clinicians, and researchers working in the field of bone health and disease, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease. (wiley-vch.de)
  • Leukemia, aplastic anemia and myelodysplastic syndromes (MDS) are three types of bone marrow disorders that affect the production of blood cells and the bone marrow. (livestrong.com)
  • People who have anemia due to bone marrow disorders may bleed easily and more profusely than others. (livestrong.com)
  • Bone marrow disorders can lead to swelling of the internal organs in some people. (livestrong.com)
  • Males with blood disorders that lead to bone marrow abnormalities may experience a swelling of the testicles. (livestrong.com)
  • For orthopaedists, emphasis is placed on operative and non-operative management of all problems of musculoskeletal disorders, including diseases of the lumbar spine, trauma, orthopaedic oncology, and degenerative diseases. (hss.edu)
  • These cells are also implicated in disorders such as Paget's disease of the bone and multiple myeloma. (sciencemag.org)
  • If the association between alkaline phosphatase and mortality has a causal link, treatment strategies that reduce alkaline phosphatase levels may improve survival in patients with CKD [chronic kidney disease] and probably in many other patients with chronic diseases and active bone disorders," Kalantar-Zadeh said. (drugs.com)
  • And her arresting appearance, which scientists refer to as a phenotype, can most likely be explained by a handful of rare genetic mutations - some already known, others newly discovered - that are linked to dwarfism and other bone and growth disorders. (ucsf.edu)
  • Metabolic bone disease is an abnormality of bones caused by a broad spectrum of disorders. (wikipedia.org)
  • These disorders are to be differentiated from a larger group of genetic bone disorders where there is a defect in a specific signaling system or cell type that causes the bone disorder. (wikipedia.org)
  • With PDB, bone resorption and subsequent new bone formation occur at an accelerated rate. (livestrong.com)
  • The basis for this severe imbalance between increased osteoclastic bone resorption and decreased bone formation has been a topic of intensive investigation over the last several years and will be reviewed in this article. (nih.gov)
  • Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption. (springer.com)
  • b) after the administration of parathyroid hormone has been terminated, the administration of a bone resorption inhibitor during a period of approximately 12 to 36 months. (google.com)
  • 4. A pharmaceutical preparation according to claim 1 adapted for said administration of bone resorption inhibitor for approximately 12 to 36 months. (google.com)
  • 5. A pharmaceutical preparation according to claim 4 , adapted for said administration of bone resorption inhibitor for approximately 12 to 18 months. (google.com)
  • 7. A preparation according to claim 1 wherein the said bone resorption inhibitor is a bisphosphonate. (google.com)
  • 9. A preparation according to claim 1 wherein the said bone resorption inhibitor is a substance with estrogen-like effect. (google.com)
  • However, lines of evidence support that a highly coordinated process of balanced bone resorption and formation mediated by BMU is disturbed (uncoupled) in periodontitis, an inflammatory bone lytic disease caused by polymicrobial infection. (nova.edu)
  • P aget's disease of bone is a chronic disorder, characterised by focal areas of excessive osteoclastic bone resorption accompanied by a secondary increase in osteoblastic bone formation. (mja.com.au)
  • Osteoblasts play important roles in bone formation and osteoclasts function in bone resorption, whereas osteocytes regulate osteoblasts and osteoclasts activities by controlling signaling pathways [ 4 ] ( Figure 1 ). (intechopen.com)
  • Osteoclasts are responsible for bone resorption in normal and disease conditions. (springer.com)
  • Less-common causes of decreased bone strength are osteogenesis imperfecta , long-term treatment with corticosteroid medications, and osteomalacia . (britannica.com)
  • Other bone diseases include Paget's disease and osteogenesis imperfecta. (news-medical.net)
  • Osteogenesis imperfecta is an inherited disease characterized by brittle bones that fracture easily. (livestrong.com)
  • With each of the 8 types of osteogenesis imperfecta, a defective gene leads to impaired production of collagen, a structural protein necessary for normal bone formation. (livestrong.com)
  • The signs and symptoms of osteogenesis imperfecta vary and may include short stature, loose joints, muscle weakness, spinal curvature, brittle teeth, bone deformity, barrel-shaped chest, hearing loss and a blue or gray tint to the whites of the eyes. (livestrong.com)
  • Osteogenesis imperfecta (OI) is a genetic disorder that prevents the body from building strong bones. (kidshealth.org)
  • Type III osteogenesis imperfecta - people with type III OI usually will be shorter than their peers, and may have severe bone deformities, breathing problems (which can be life-threatening), brittle teeth, a curved spine, ribcage deformities, and other problems. (kidshealth.org)
  • Researchers from the University of Zurich and University Children's Hospital Zurich have discovered the first X-chromosome-inherited type of the congenital disease osteogenesis imperfecta, also known as brittle-bone disease. (medicalnewstoday.com)
  • Surprisingly, mutations in the gene MBTPS2 also cause a completely different disease, namely osteogenesis imperfecta,' explains Marianne Rohrbach. (medicalnewstoday.com)
  • The weak tendons and fragile bones characteristic of osteogenesis imperfecta, or brittle bone disease, stem from a genetic mutation that causes the incorrect substitution of a single amino acid in the chain of thousands of amino acids making up a collagen molecule, the basic building block of bone and tendon. (redorbit.com)
  • It stimulates a process in the body called osteogenesis, which involves the growth of new bone and the repair of damaged bone. (medindia.net)
  • In an American study, mice were bred with osteogenesis imperfecta (OI) and the activity of a protein which shapes and reshapes bones was monitored. (thedailystar.net)
  • The brace eases the pressure on his bones, weakened since birth by osteogenesis imperfecta congenial, a rare disease that makes them so brittle that they break after even slight falls. (sun-sentinel.com)
  • Hot on the heels of the discovery of a gene involved in a previously unexplained form of osteogenesis imperfecta (OI), researchers have found another genetic defect involved in the bone-weakening disorder. (nih.gov)
  • Osteogenesis imperfecta (OI) or "brittle bone disease" is a congenital disorder in which a person is born with very brittle bones, usually due to either a complete lack of or incorrectly formed type I collagen. (hss.edu)
  • About 40-50% of people with the inherited version of Paget's disease have a mutation in the gene SQSTM1, which encodes a protein, called p62, that is involved in regulating the function of osteoclasts (bone cells). (wikipedia.org)
  • Bones are maintained by a tightly controlled balance between bone-building cells, known as osteoblasts, and bone-degrading cells called osteoclasts. (medicalnewstoday.com)
  • contains, nerves, vessels, collagen, and living cells including osteoblasts (helps in formation of bones), and osteoclasts(bone cells which removes old bone tissues). (hpathy.com)
  • Special bone cells, called osteoclasts, remove old bone tissue. (thebody.com)
  • Osteoclasts , which break down and remove old bone. (mydr.com.au)
  • The osteoclasts become over-active, which means they break down more bone than normal. (mydr.com.au)
  • In the healthy skeleton, there is a dynamic balance between the breakdown of old bone tissue (performed by cells called osteoclasts) and the building of new bone tissue (performed by cells called osteoblasts). (myeloma.org)
  • Myeloma cells produce osteoclast-activating factors, signaling osteoclasts to break down bone uncontrollably. (myeloma.org)
  • MiRNAs also regulate bone cells such as osteoblasts, osteoclasts, and osteocytes, which function in the mechanism of bone modeling and bone remodeling [ 4 ]. (intechopen.com)
  • found that these mice had osteoclasts that were larger and more numerous with increased resorptive activity, which led to decreased bone volume. (sciencemag.org)
  • Bone in particular is vulnerable to inflammatory assaults because its integrity depends on the activity of osteoclasts, which arise from myeloid precursors. (springer.com)
  • These structural changes cause the bone to weaken, which may result in deformity, pain, fracture, or arthritis of associated joints. (wikipedia.org)
  • A fracture occurs when the bone tissue is subjected to tensile, compressive, or shear forces in excess of its strength. (britannica.com)
  • In the elderly, fracture is usually caused by mild forces acting on brittle bone. (britannica.com)
  • Examples include fracture of the thighbone and fracture of the bones of the foot (march fracture) in soldiers during their initial months of physical training. (britannica.com)
  • Bone diseases associated with pathologic fracture are osteomalacia, Paget disease, and radiation injury to bone. (britannica.com)
  • The bone blood vessels rupture when there is fracture. (britannica.com)
  • Although physical injury, causing fracture , dominates over disease , fracture is but one of several common causes of bone disease, and disease is in fact a common cause of fracture. (britannica.com)
  • Low bone mass is when bones lose minerals, like calcium, that make them strong, and as a result, bones become weak and fracture easily. (news-medical.net)
  • Each year, 1.5 million Americans suffer a fracture because of weak bones. (news-medical.net)
  • Most cases of osteonecrosis occur due to bone trauma, such as a hip fracture or dislocation. (livestrong.com)
  • Lifetime risks of hip, colles , or vertebral fracture and coronary heart disease among white postmenopausal women. (medindia.net)
  • If the biopsy confirms that the bony defect has been caused by metastatic disease, the orthopedist must then decide if the defect fits the criteria for an impending fracture. (medscape.com)
  • As the literature has shown, a drill hole that has been placed inappropriately in the lateral femoral shaft (at or below the level of the lesser trochanter) for fixation of a nonneoplastic femoral neck fracture results in a high risk of bone fracture with weightbearing through the lateral femoral cortical drill hold defect. (medscape.com)
  • The disease is often asymptomatic, but can cause bone pain, deformity, fracture and other complications. (mja.com.au)
  • This makes bones more fragile and weak and can predispose them to fracture. (thebody.com)
  • Symptoms may include joint, back and/or hip pain, but you know you have bone disease when you get a fracture that is not due to, say, trauma or a fall. (thebody.com)
  • Recently Duerksen and colleagues published on fracture risk assessment in celiac disease - a registry-based cohort study (1). (osteoporosis.ca)
  • This study confirms that celiac disease is associated with an increased risk of fracture. (osteoporosis.ca)
  • This registry-based study supports previous research (2) indicating that celiac disease appeared to be associated with an increased risk of fracture, however previous research was not conclusive as it was not clear if the increased fracture risk was due to the presence of celiac disease. (osteoporosis.ca)
  • People with celiac disease benefit from an assessment of bone health and fracture risk. (osteoporosis.ca)
  • How does FRAX calculate fracture risk in celiac disease? (osteoporosis.ca)
  • The FRAX calculation appropriately predicted a higher fracture risk if the presence of celiac disease was considered as a secondary cause, or if BMD data was entered (1). (osteoporosis.ca)
  • Fracture risk assessment in celiac disease: a registry-based cohort study. (osteoporosis.ca)
  • The weakened bone is more likely to break under minor pressure or injury (pathologic fracture). (myeloma.org)
  • When TGF was blocked with an antibody, the mice's bones withstood "higher maximum load and ultimate strength" and showed "improved whole bone and tissue strength", suggesting "resistance to fracture", the study said. (thedailystar.net)
  • A protein-rich supplementation given to lean elderly female hip fracture patients increased the total body bone mineral density. (greenmedinfo.com)
  • For larger bone lesions, treatment may include medication, physical therapy and/or surgery. (livestrong.com)
  • Multiple myeloma (MM) is a malignancy of plasma cells characterized by growth in the bone marrow (BM) environment and the development of lytic lesions in the skeleton. (springer.com)
  • The hallmark of MM bone disease is the development of osteolytic lesions without associated osteoblastic activity. (springer.com)
  • The absence of reactive bone formation renders MM-associated skeletal lesions silent on bone scan, and helps to explain the. (springer.com)
  • They found that myeloma cells produced large amounts of an enzyme called thymidine phosphorylase (TP) that correlated with more severe bone lesions in patients. (medicalnewstoday.com)
  • Treating myeloma-bearing mice with TP inhibitors markedly reduced bone lesions, raising the possibility of repurposing these drugs to treat cancer-driven bone disease. (medicalnewstoday.com)
  • Central lesions with a 50% symmetrical loss of bone produce a 60% loss of bending strength. (medscape.com)
  • A strong case be made for also treating asymptomatic patients with involvement of long bones, vertebrae or base of skull, patients with significant osteolytic lesions, and perhaps all younger patients. (mja.com.au)
  • Bone metastases in breast cancer: higher prevalence of osteosclerotic lesions. (medscape.com)
  • one or more lytic bone lesions detected on CT scan, including whole-body low-dose CT or PET/CT. (myeloma.org)
  • Focal lesions are early, abnormal areas in the bone marrow that signal the development of a lytic lesion within the next 18-24 months. (myeloma.org)
  • Lytic lesions are areas where bone has been destroyed, leaving a hole in the bone. (myeloma.org)
  • Lytic lesions in the long bones of the leg or in the hip may require surgery to reinforce and stabilize the bone. (myeloma.org)
  • MRI (magnetic resonance imaging) is a sensitive study for detecting early focal lesions in the bone marrow. (myeloma.org)
  • of the disease from the skin lesions and facial disfiguration that it can cause. (coursera.org)
  • Nomenclature of Subchondral Nonneoplastic Bone Lesions. (harvard.edu)
  • Although many people with PDB have no symptoms, bone deformities can lead to joint pain, bowing of the legs, headaches and hearing loss. (livestrong.com)
  • It can also lead to bone deformities. (kidshealth.org)
  • This makes their bones fragile, but they don't have bone deformities. (kidshealth.org)
  • The patients suffer from heightened bone fragility, bone deformities and stunted growth. (medicalnewstoday.com)
  • This process leads to abnormal enlargement and bone deformities. (rxlist.com)
  • This disease causes crippling deformities of the spine and joints, especially in children whose skeletons are still forming. (newkerala.com)
  • These images are a random sampling from a Bing search on the term "Metabolic Bone Disease Following ICU Admission. (fpnotebook.com)
  • Additionally, we work closely with other Departments to provide care for patients who have complex metabolic bone disease. (tuftsmedicalcenter.org)
  • The Metabolic Bone Disease Fellowship program within the combined orthopaedic, medical and radiology bone consortium represents the continued commitment of Hospital for Special Surgery to train clinicians and scientists in basic and applied research. (hss.edu)
  • The HSS Metabolic Bone Disease Fellowship is designed to provide the participant with an ongoing, in-depth experience in the medical management of patients with metabolic bone disease. (hss.edu)
  • Previous training for the Metabolic Bone Disease Fellowship includes all medical residencies and fellowships, physical medicine and rehabilitation, radiology, pathology and orthopaedic surgery. (hss.edu)
  • The Metabolic Bone Disease Fellows are the primary surgeons on service cases under the supervision of the attending staff and are the primary assistants to the attending physician on private operative cases. (hss.edu)
  • Alkaline phosphatase levels are routinely measured in dialysis patients to monitor for metabolic bone disease, a common complication of CKD. (drugs.com)
  • Genetic causes may or may not involve a family history of Paget's disease. (wikipedia.org)
  • The new discovery improves the genetic diagnosis of the disease and paves the way to possible improved treatment options for patients. (medicalnewstoday.com)
  • The Division of Bone Marrow Transplantation and Immune Deficiency at Cincinnati Children's is an international leader in delivering cutting-edge therapies for many diseases such as refractory, or hard-to-treat, cancers, rare genetic conditions affecting the immune system, hemoglobinopathies and bone marrow failure syndromes. (cincinnatichildrens.org)
  • BOSTON , April 11, 2019 /PRNewswire/ -- Boston -based Embark Veterinary Inc., the world leader in dog genetics, announced today that it raised $10 million in Series A funding, a milestone that enables the young biotech company to build on its early consumer success and expand its research in canine health and genetic disease. (prnewswire.com)
  • Owners want to know all about their dogs - not just the breed, but the genetic markers that can shed light on possible diseases they may face in the future,' said Ryan Boyko , Embark's CEO and co-founder. (prnewswire.com)
  • Some of the most common diseases found in dogs are genetic conditions - bladder stones, heart disease, and cancer can be traced genetically. (prnewswire.com)
  • Medical experts may be able to solve the mystery behind a rare bone disease after two ancient skeletons with the genetic bone disease were unearthed from a medieval Irish graveyard. (medindia.net)
  • Brittle bone disease is a lifelong genetic disorder that causes your bones to break very easily, usually without any type of injury, as from a fall. (webmd.com)
  • Genetic testing can confirm brittle bone disease. (webmd.com)
  • Anomalies of the expression of T-cell receptor variable genes in haemochromatosis: an MHC-class I linked genetic disease of iron overload. (uptodate.com)
  • The cause of Paget's disease is unknown, but there is a strong genetic influence. (mja.com.au)
  • There is a strong genetic component, and 15%-20% of those affected have a first-degree relative with the disease. (mja.com.au)
  • Dr Lee added: "We now have a deeper understanding for how genetic mutations that affect collagen and collagen processing enzymes cause weak bones. (thedailystar.net)
  • The diseases, caused by genetic mutations, can cause respiratory problems among infants and lead to death, while others suffer from dwarfism and other complications throughout their lives. (japantimes.co.jp)
  • MPNs are caused by genetic changes (mutations) of the hematopoietic cells in the bone marrow that are acquired spontaneously, due to certain genetic predispositions or as a result of environmental influences. (innovations-report.com)
  • Using DNA extracted from the bone marrow, researchers did a whole-genome analysis which determined that she was South American, "with genetic variations that identified her as being from the Andean region inhabited by the Chilean Chilote Indians," said the report. (yahoo.com)
  • Her lab has already performed a genetic test confirming that a child's unknown disease was recessive OI. (nih.gov)
  • The results revealed four new SNVs - a type of genetic mutation at the individual level - in genes that were known to cause bone diseases, like scoliosis or dislocations, as well as two more SNVs in genes involved in producing collagen. (ucsf.edu)
  • For example, genetic or hereditary hypophosphatemia may cause the metabolic bone disorder osteomalacia. (wikipedia.org)
  • Although there is currently no treatment for the genetic condition, replacement of phosphate often corrects or improves the metabolic bone disorder. (wikipedia.org)
  • Your bones normally reach their maximum mass at age 25 to 30 after which they gradually lose density. (livestrong.com)
  • This is a review of published literature that reports spinal bone density in either T or Z scores. (washington.edu)
  • Low serum bone gamma-carboxyglutamic acid protein concentrations in patients with cystic fibrosis: correlation with hormonal parameters and bone mineral density. (washington.edu)
  • Bone mineral density and body composition in adult patients with cystic fibrosis. (washington.edu)
  • Bone density in children and adolescents with cystic fibrosis. (washington.edu)
  • Still, just to make sure, Benghauser went in for a test that measured the density of her bones. (npr.org)
  • It's also important to get a bone-density test. (wbaltv.com)
  • All men and women over 50 years of age and living with HIV should obtain a baseline bone mineral density test. (thebody.com)
  • If the results are normal, the bone mineral density test should be repeated every two to five years. (thebody.com)
  • Bone mineral density (125I photon absorptiometry) was lower in 20 untreated adult celiac patients than in sex- and age-matched controls (p less than 0.001), and plasma alkaline phosphatase, parathyroid hormone, urinary hydroxyproline/creatinine levels were higher than normal (p less than 0.05, less than 0.001, less than 0.05, respectively). (nih.gov)
  • After 12 months' treatment, bone turnover markers showed a decrease, which did not reach statistical significance, and bone mineral density did not show significant modifications compared with base line in either group. (nih.gov)
  • Preliminary studies suggest that the disease is eight times more common in women than men, possibly because women's bone structure has a naturally lower density. (orlandosentinel.com)
  • On his Web site, Dr. Reginald B. Cherry cites a study published in the American Journal of Epidemiology claiming an increase in the risk of heart disease for women with low bone density. (charismamag.com)
  • Paget's disease of bone (commonly known as Paget's disease or historically, osteitis deformans) is a condition involving cellular remodeling and deformity of one or more bones. (wikipedia.org)
  • There is a hereditary factor in the development of Paget's disease of bone. (wikipedia.org)
  • Two genes, SQSTM1 and RANK, and specific regions of chromosome 5 and 6 are associated with Paget's disease of bone. (wikipedia.org)
  • Paget's disease of bone is associated with mutations in RANK. (wikipedia.org)
  • Signs of Paget's disease of bone include: pain associated with bones and joints, headaches, hearing loss, enlargement or bowing of bones, tingling or numbness. (rheumatology.org)
  • Paget's disease of bone is an uncommon, chronic bone disorder that occurs in only about one percent of people in the United States and slightly more often in men than in women (three to two). (rheumatology.org)
  • Paget's disease of bone is a progressive, often crippling disorder of bone remodeling that commonly involves the spine, pelvis, legs, or skull (although any bone can be affected). (nih.gov)
  • Paget's disease of bone (which is different from Paget's disease of the breast) is a chronic disease of bone characterized by excessive breakdown and reformation of bone. (rxlist.com)
  • Paget's disease of bone may not produce symptoms. (rxlist.com)
  • Medical professionals do not understand the cause of Paget's disease of bone. (rxlist.com)
  • Paget's disease of bone is common, affecting up to 4% of Australians over the age of 55 years. (mja.com.au)
  • Michael Baum, emeritus professor of surgery at University College London, suggested that the sitter had Paget's disease of bone. (wikipedia.org)
  • Paget's may first be noticed as an increasing deformity of a person's bones. (wikipedia.org)
  • Bone diseases affect normal growth, development or remodeling leading to weakness and/or deformity. (livestrong.com)
  • This creates a tiny rift in the tissue, which when repeated in many molecules, leads to brittle tissue, broken bones, deformity and, in the most severe form of the disease, death. (redorbit.com)
  • 1 The disease results in bone expansion and structural weakness, which can cause pain, deformity, and a range of complications. (mja.com.au)
  • The sites of bone marrow location include the sternum (middle of the chest), pelvis (hip bone), and femur (thigh bone). (news-medical.net)
  • Paget's disease may affect any one or multiple bones of the body (most commonly pelvis, femur, and lumbar vertebrae, and skull), but never the entire skeleton, and does not spread from bone to bone. (wikipedia.org)
  • Individuals with Paget's disease experience rapid isolated bone repair, which causes a variety of symptoms from softer bones to enlarged bone growth, typically involving one or more bones of the pelvis, low back (spine), hips, thighs, head (skull) and arms. (rheumatology.org)
  • The involved bone can be soft, leading to weakness and bending of the pelvis, low back (spine), hips, thighs, head and arms. (rheumatology.org)
  • The spine, pelvis, skull and leg bones are most commonly affected. (livestrong.com)
  • The spine, the thighbone (femur), the pelvis, the skull, collarbone (clavicle), and the upper arm bone (humerus) are the most common sites of involvement. (rxlist.com)
  • Most commonly, the disease involves the pelvis, lumbosacral spine, skull, femur or tibia, but any bone may be affected, and the disease may be localised to one or a few bones or widespread throughout the skeleton. (mja.com.au)
  • Any bone in the body can develop Paget's disease, but it particularly affects the skull, spine, pelvis, legs and arms. (mydr.com.au)
  • The bones most commonly affected are the spine, pelvis, ribs, skull, and the long bones of the arms and legs. (myeloma.org)
  • The bone marrow is a soft spongy tissue within the bones. (news-medical.net)
  • Both the strength of the bone tissue and the nature of the forces acting on bone change from infancy to old age , both normally and as a result of disease . (britannica.com)
  • The bone tissue in young adults has high resistance to mechanical deformation. (britannica.com)
  • In the elderly the bone tissue becomes more brittle, especially the cancellous bone in vertebrae and in shoulder, wrist, hip, and knee joints. (britannica.com)
  • Many diseases decrease the strength of the bone tissue, and some expose the body to increased mechanical forces. (britannica.com)
  • Inactivity has a profound effect on the bone tissue , probably because the mechanical stimulus to bone formation is decreased. (britannica.com)
  • More often than not the three types of bone infection as well as soft-tissue infection become concurrent if the initial event is not brought under prompt control. (springer.com)
  • Like all parts of your body, your bones are living tissue. (livestrong.com)
  • In some cases, surgery is need to remove infected bone tissue. (livestrong.com)
  • With osteonecrosis, loss of blood supply causes death of bone tissue. (livestrong.com)
  • In what may be the first detailed molecular-based multi-scale analysis of the role of a materials' failure in human disease, a paper in the Aug. 4 issue of Biophysical Journal describes exactly how the substituted amino acid repels other amino acids rather than forming chemical bonds with them, creating a radically altered structure at the nanoscale that results in severely compromised tissue at the macroscale. (redorbit.com)
  • He sees the application of this approach to collagen-based diseases as a starting point that could lead to a similar analysis of the mechanical properties of tissue involved in other protein-based diseases. (redorbit.com)
  • They learned that the mutations creating the most severe form of the disease also correlate with the greatest magnitude of adverse effects in creating more pronounced rifts in the tissue, which lead to the deterioration and failure of the tissue. (redorbit.com)
  • Newer technology, called tissue engineering, encourages your own body to regenerate bone and tissue at a faster rate. (webmd.com)
  • How are soft tissue grafts used to treat gum disease? (webmd.com)
  • In Aim2, the efficacy of systemically administered CMC2.24 to restore the new bone formation at the periodontal lesion induced in a mouse model of periodontitis will be evaluated by monitoring the activity of MT1-MMP and levels of sSema4D produced in diseased gingival tissue in comparison to other authentic anti-osteogenic factors, such as Sclerositin or Noggin. (nova.edu)
  • instead, there was rapid bone formation around some of the bones, as well as bone formation in soft tissue. (livescience.com)
  • In the 2008 report, the doctors diagnosed the man with a condition called heterotopic ossification, which involves bones growing abnormally in soft tissue, after an injury. (livescience.com)
  • Paget's disease is a chronic bone disorder due to irregular breakdown and formation of bone tissue. (rxlist.com)
  • In normal bone, the bone tissue is constantly being broken down, absorbed into the body, and then rebuilt with new cells. (healthlinkbc.ca)
  • In Paget's disease, bone tissue is broken down and absorbed much faster than normal, so the body speeds up the bone rebuilding process. (healthlinkbc.ca)
  • Fraker focused on bone marrow, which is a large, highly active, and responsive tissue. (futurity.org)
  • And even though people often think of bones as supportive structures, they are actually living tissue. (thebody.com)
  • Their risk increases during menopause because they lose bone tissue faster as their hormone levels change. (thebody.com)
  • Of note, clinical immunology is largely overlapping with rheumatology and manifests some peculiar interests such as immune deficiencies and shared grounds such as connective tissue diseases. (unimi.it)
  • PET is used to assess disease both in bone and in soft tissue (extramedullary disease). (myeloma.org)
  • Heterotopic ossification (HO) is a painful and often debilitating abnormal buildup of bone tissue which consists of ectopic bone formation within soft tissues after surgery or trauma. (emaxhealth.com)
  • After opening with an examination of the epidemiology and impact of MBD, the biology of bone metastases are discussed, along with considerations of the tissue of origin. (springer.com)
  • Coincidentally it is also used to treat bone and tissue infections. (healingwell.com)
  • It is possible that you literally have an infection of the bone and tissue, either with the lyme or some other opportunistic organism. (healingwell.com)
  • In addition to eliminating smoking and drinking alcohol, Cherry recommends physical activity and the proper balance of nutrients including calcium (1,000 mg a day under age 50 and 1,200 mg over age 50) to strengthen and support bone tissue. (charismamag.com)
  • Some patients treated by the Bone and Soft Tissue Tumour Service have tumours in their bones which have come from other sites of the body, for example from breast or kidney cancer. (newcastle-hospitals.org.uk)
  • You can find more information in our bone and soft tissue tumour service webpages . (newcastle-hospitals.org.uk)
  • The image below it depicts a fibril with brittle bone disease displaying the small rifts (in orange) that form in collagen tissue at the sites where an incorrect amino acid has been substituted for glycine. (medgadget.com)
  • Although there is no cure for Paget's disease, medications (bisphosphonates and calcitonin) can help control the disorder and lessen pain and other symptoms. (wikipedia.org)
  • Legg-Calvé-Perthes disease is a rare childhood bone disorder similar to osteonecrosis of the femoral head in adults. (livestrong.com)
  • Renal Osteodystrophy which is referred to as Mineral Bone Disorder is a result of imbalance in calcium, phosphorus, parathyroid hormone and Vitamin D levels. (medindia.net)
  • Paget disease of the bone is a chronic bone disorder. (hopkinsmedicine.org)
  • These types of complaints occur when a person with a bone marrow disorder has a very low red blood cell count. (livestrong.com)
  • Osteochondrodysplasia is a general term for a disorder of the development of bone and cartilage. (wikipedia.org)
  • Scientists long suspected that other causes of the disease existed, however, because about 15% of people affected with the disorder didn't have mutations in their collagen genes. (nih.gov)
  • LIGHT/TNFSF14 increases osteoclastogenesis and decreases osteoblastogenesis in multiple myeloma-bone disease," Oncotarget , vol. 5, no. 24, pp. 12950-12967, 2014. (hindawi.com)
  • The findings in mice suggest that clinically approved inhibitors of the enzyme could potentially be repurposed for patients with multiple myeloma as well as breast, lung, and other solid tumors that metastasize to the bones. (medicalnewstoday.com)
  • To better understand the mechanism underlying myeloma-induced bone disease, Huan Liu and colleagues analyzed samples from multiple myeloma patients and a mouse model of the disease. (medicalnewstoday.com)
  • Currently, three such bone-modifying agents (BMAs) are available for multiple myeloma. (myeloma.org)
  • Curcumin inhibits inflammation-induced bone resportion that is frequently associated with cancers such as metastatic breast cancer and multiple myeloma. (greenmedinfo.com)
  • A number of childhood diseases cause rickets, a condition that results from a delay in depositing calcium phosphate mineral in growing bones. (nih.gov)
  • Blood and urine tests will rule out other health conditions that can cause weak bones, such as rickets . (webmd.com)
  • Diagnosed in toddlers, X-linked hypophosphatemia (XLH) is the most common form of heritable rickets, in which soft bones bend and deform, and tooth abscesses develop because infections penetrate soft teeth that are not properly calcified. (eurekalert.org)
  • Bone-Weakening Disease, Rickets, Reappears in U.S. (voanews.com)
  • Rickets, a bone-weakening disease of children caused by a lack of vitamin D, disappeared from the U.S. about 50 years ago, following the introduction of vitamin D-fortified foods. (voanews.com)
  • The federal Centers for Disease Control has been studying the increased reports of rickets around the country. (voanews.com)
  • Patients who have rickets experience a softening and weakening of their bones traced to a vitamin deficiency. (xconomy.com)
  • In osteoarthritis , because the weight distribution across the knee or hip joints is uneven, the bone beneath the cartilage thickens on the compression side of the joint and atrophies on the extension side. (britannica.com)
  • Brittle bone disease affects about one in 16,000 people worldwide, and defective collagen is implicated in many other medical conditions, including Alport syndrome (kidney disease) and Ehlers-Danlos syndrome (overly-flexible skin and joints). (redorbit.com)
  • Splints or braces to support your bones and joints and to help keep weak bones from breaking. (healthlinkbc.ca)
  • Sore joints or arthritis due to damage to the cartilage which lines the ends of bones. (mydr.com.au)
  • Bone pain, an aching of the joints and headaches are all symptoms of bone marrow disease. (livestrong.com)
  • My pains presented as what feels like deep bone or toothache like pains that jump all over the place in my bones and joints. (healingwell.com)
  • To have strong bones when you are young, and to prevent bone loss when you are older, you need to get enough calcium , vitamin D , and exercise. (medlineplus.gov)
  • The most important time to ensure calcium and vitamin D levels are adequate is while the bones are being formed. (bbc.co.uk)
  • The researchers also showed that Largazole mixed with collagen and calcium phosphate, bone components, helped heal fractured bones in laboratory mice and rabbits. (medindia.net)
  • Calcium and vitamin D are known to improve bone health. (medindia.net)
  • Including primarily collagen fibers and crystalline salts, the crystalline salts deposited in the matrix of bone are mainly composed of calcium and phosphate. (hpathy.com)
  • The bones are also store another vital substance of the body- calcium. (hpathy.com)
  • XLH is caused in part by renal phosphate wasting, which is the urinary loss from the body of phosphate, an important building block of bones and teeth, along with calcium. (eurekalert.org)
  • Celiac disease results from an immune reaction to the gluten present in wheat and other foods - ingestion of these foods results in the small bowel lining becoming flat, and affects absorption of nutrients including calcium, phosphate and vitamin D which are essential for bone mineralization and bone health. (osteoporosis.ca)
  • It is important to ensure that adequate calcium, phosphate and vitamin D are being ingested and absorbed, as malabsorption of these essential nutrients can impair bone quality and strength. (osteoporosis.ca)
  • As bone is broken down, calcium is released from the bones into the bloodstream. (myeloma.org)
  • The bones are made mostly by calcium, and in turn help the this balance homeostasis). (148apps.com)
  • Vitamin D helps the body absorb calcium and phosphate, which are important to bone health. (xconomy.com)
  • These malignancies can originate in the bone (primary tumors) or, much more commonly, result from the seeding of bone by tumors outside of the skeleton (metastatic tumors). (nih.gov)
  • It is often difficult to determine whether a bony defect found during a bone survey for metastatic disease is the result of that disease or of some other condition. (medscape.com)
  • Metastatic bone disease: a guide to good practice (2015 revision). (medscape.com)
  • Providing an integrated approach to the diagnosis and management of patients with metastatic bone disease (MBD), this comprehensive text combines discussion of the pathobiology of the disease with the latest oncological and orthopedic treatment modalities. (springer.com)
  • Taken together, Metastatic Bone Disease is an excellent resource for orthopedic surgeons and cancer specialists alike. (springer.com)
  • Substantial evidence from preclinical studies shows that increased expression of integrin αvβ3 in tumor cells promotes the metastatic and bone-invasive phenotype. (mdpi.com)
  • This page gives you information about metastatic bone disease and its treatment. (newcastle-hospitals.org.uk)
  • The team can offer specialist surgery for metastatic bone disease and can help to confirm the diagnosis of metastatic bone disease when it is important to do so. (newcastle-hospitals.org.uk)
  • Normally this makes it possible for another group of cells to rebuild the bone, renewing the skeleton and maintaining its strength as the body ages. (eurekalert.org)
  • But if the bone dismantlers become more active than the bone builders, weakening of the skeleton and bone loss result. (eurekalert.org)
  • This loss of osteopontin, a known potent inhibitor of mineralization (or calcification) in the skeleton and dentition, normally allows bones and teeth to mineralize and thus harden to meet the biomechanical demands placed on them. (eurekalert.org)
  • While not life-threatening, this decreased mineralization of the skeleton (osteomalacia), along with the soft teeth, soon leads to a waddling gait, short stature, bone and muscle pain, weakness and spontaneous tooth abscesses. (eurekalert.org)
  • These two actions - breakdown and build-up of bones - are coupled in a delicate interplay to ensure the health of the skeleton. (myeloma.org)
  • The skeleton, discovered in a leather pouch behind an abandoned church, was pristine: a tiny figure, just six inches long, with a cone-shaped head, 10 pairs of ribs, and bones that looked like those of an 8-year-old child. (ucsf.edu)
  • Recent guidelines address the aberrations in bone metabolism and disease that occur as a complication of chronic kidney disease. (medscape.com)
  • [ 2 ] In the current article, we summarize those components of a further set of guidelines that are relevant to the practicing pharmacist-the K/DOQI clinical practice guidelines for bone metabolism and disease in CKD. (medscape.com)
  • These activated proteins bind to the DNA and regulate genes involved in the bone and sterol metabolism and the regulation of cell stress . (medicalnewstoday.com)
  • The culprit is a change in the bone metabolism, which no longer seems to be impaired in the case of dermatological diseases. (medicalnewstoday.com)
  • The scientists hope to gain new insights into bone developments and sterol metabolism, which could one day mean improved treatment options for patients. (medicalnewstoday.com)
  • These activated pro-teins bind to the DNA and regulate genes involved in the bone and sterol metabolism and the regula-tion of cell stress. (innovations-report.com)
  • The disease is named after Sir James Paget. (wikipedia.org)
  • The exact cause of Paget disease of the bone is unknown. (hopkinsmedicine.org)
  • What are the symptoms of Paget disease of the bone? (hopkinsmedicine.org)
  • Very rarely, Paget disease may progress to bone cancer. (hopkinsmedicine.org)
  • How is Paget disease of the bone diagnosed? (hopkinsmedicine.org)
  • Any condition of bone growth or an increased activity of bone cells, including Paget disease, will cause alkaline phosphatase levels to rise. (hopkinsmedicine.org)
  • How is Paget disease of the bone treated? (hopkinsmedicine.org)
  • However, this pain pattern can be present in patients with osteomyelitis and Paget disease, and in these instances, it is also nonspecific. (medscape.com)
  • The condition is named after Sir James Paget, a British doctor who described the disease in the 1870s. (mydr.com.au)
  • For other diseases named after Paget, see Paget's disease (disambiguation) . (wikipedia.org)
  • A computed tomography scan displayed a marked widening of the diploic space of the calvaria with lytic and sclerotic regions ( Figure , A and B), which is pathognomonic of advanced Paget disease affecting the skull. (mja.com.au)
  • MDS is a group of diseases where there is abnormal bone marrow cell production. (news-medical.net)
  • The abnormal bone formation is associated with recruitment of abnormal blood vessels, forcing the cardiovascular system to work harder (pump more blood) to ensure adequate circulation. (wikipedia.org)
  • Paget's disease is a problem of abnormal bone growth. (healthlinkbc.ca)
  • As a result of new abnormal bone being produced, affected bones become enlarged and misshapen. (mydr.com.au)
  • Pain, numbness, weakness or paralysis in different parts of the body, due to the abnormal bone pressing on or pinching nerves in the spinal cord. (mydr.com.au)
  • A very rare complication in less than 1% of people with Paget's disease is the development of bone cancer in the abnormal bone. (mydr.com.au)
  • the other two had a nonfatal form with severely abnormal bone development. (nih.gov)
  • Blood tests taken most often will indicate an increase in serum alkaline phosphatase (SAP), which is reflective of the rapid new bone turnover. (rheumatology.org)
  • A blood test called serum alkaline phosphatase measures the levels of alkaline phosphatase (an enzyme found throughout the body) in the bone. (hopkinsmedicine.org)
  • The most important one for diagnosing Paget's disease is a blood test for alkaline phosphatase, an enzyme made by bone. (healthlinkbc.ca)
  • THURSDAY, July 31 -- High levels of alkaline phosphatase -- a routinely measured marker of bone disease -- may signal an increased risk of death among patients receiving dialysis for chronic kidney disease, say U.S. researchers. (drugs.com)
  • In dialysis patients, increased levels of alkaline phosphatase in the blood indicate a so-called high-turnover bone disease, which can happen due to hormonal imbalance in CKD," said Kalantar-Zadeh, who added that previous studies have identified a possible link between bone disease and cardiovascular health in CKD patients. (drugs.com)
  • In adults, the equivalent disease is called osteomalacia. (nih.gov)
  • WHY TO AVOID BISPHOSPHONATES in patients with cystic fibrosis Etidronate (Didronel) Pamidronate (Aredia) Alendronate (Fosamax) May cause osteomalacia Patients with C.F. already prone to this May inhibit primary modeling of growing bone Safety in children not established only reported in a few cases should do bone biopsies if done on research basis Half-life in bone is >10 years! (washington.edu)
  • Heart failure is a rare, reported consequence of severe Paget's disease (i.e. more than 40% skeletal involvement). (wikipedia.org)
  • Poliomyelitis affecting the lower extremity in children results in short, thin bones with sometimes severe leg-length discrepancy. (britannica.com)
  • A surface molecule on bacteria that directs bone cells to die has been identified by scientists who claim that this discovery could assist in developing new treatments for severe bone disease. (medindia.net)
  • General symptoms of brittle bone disease may be mild or very severe. (webmd.com)
  • Severe forms of the disease can affect the shape of the rib cage and spine, which can lead to life-threatening breathing problems. (webmd.com)
  • Watching a young patient suffer through the pain of severe colitis bolstered Fraker's need to research this devastating disease. (futurity.org)
  • Chronic graft-versus-host-disease (cGVHD) is a frequent and severe complication of allogeneic hematopoietic stem cell transplantation (AHSCT). (nature.com)
  • In severe cases, people with OI can have between 200 and 300 fractions by the time they reach age 18, the Brittle Bone Society said. (thedailystar.net)
  • Three genes linked to the development of Paget's disease, a painful bone condition, have been identified by an international team of scientists, led by the University of Edinburgh. (medindia.net)
  • TP triggered epigenetic changes in the expression of osteoblast as well as osteoclast differentiation-associated genes, leading to both blunted bone growth and bone breakdown. (medicalnewstoday.com)
  • Nolas said "a relatively short list of mutations in genes known previously to be associated with bone development" were found in genes related to dwarfism, scoliosis, and musculoskeletal abnormalities. (yahoo.com)
  • About 85% of all cases are caused by dominant mutations in the two genes for type I collagen, an important building block for bone. (nih.gov)
  • Bone may become dense, but fragile, because of excessive breakdown and deformation of bone. (hopkinsmedicine.org)
  • Mechanisms of disease: mechanisms of bone metastasis. (springer.com)
  • Mundy GR, Yoneda T. Facilitation and suppression of bone metastasis. (medscape.com)
  • Bone Metastasis: Current State of Play. (medscape.com)
  • Indole-3 carbinol, a compound found in cabbage, may prevent and treat breast cancer bone metastasis. (greenmedinfo.com)
  • Ipriflavone inhibits the growth of cancer cells and bone metastasis of human breast cancer. (greenmedinfo.com)
  • Specifically, the focus will be the role of αvβ3 in modulating cancer metastasis to bone and tumor cell response to the bone microenvironment, including downstream signaling pathways that contribute to tumor-induced osteolysis. (mdpi.com)
  • Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates," Journal of Clinical Oncology , vol. 27, no. 10, pp. 1564-1571, 2009. (hindawi.com)
  • However, the lytic bone disease in MM differs from that in other cancer patients who have lytic bone metastases. (nih.gov)
  • Bone biopsies can be accomplished in a number of ways, but for the diagnosis of bony metastases, the most appropriate and least invasive method is needle biopsy. (medscape.com)
  • Quality of life after palliative radiation therapy for patients with painful bone metastases: results of an international study validating the EORTC QLQ-BM22. (medscape.com)
  • Kinetic analysis of 18F-fluoride PET images of breast cancer bone metastases. (medscape.com)
  • A better understanding of integrin dysregulation in cancer is critical to developing new therapeutics for the prevention and treatment of bone metastases. (mdpi.com)
  • A discovery in mice could help to treat people with a form of brittle bone disease, scientists said. (thedailystar.net)
  • Nervous system problems may occur in Paget's disease, resulting from increased pressure on the brain, spinal cord, or nerves, and reduced blood flow to the brain and spinal cord. (wikipedia.org)
  • Other symptoms may occur, depending on which part of the body is affected by Paget's disease. (healthlinkbc.ca)
  • Eupatorium Perf - it is an excellent remedy for bone pains occur in fever, bony pain associated with marked restlessness. (hpathy.com)
  • Excessive fatigue and weakness are symptoms of anemia that may occur in patients with bone marrow disease. (livestrong.com)
  • Tests showed that the bones in the man's spine, neck and hips were denser than normal. (livescience.com)
  • 70% of these patients have bone loss in the spine. (myeloma.org)
  • SYMPTOMS migratory joint/bone pain, extreme joint cracking, feet buzzing/vibrating, right eye pain,mid spine soreness (like a constant bruise) fatigue and dizzy spells, bumps and indents on nails. (healingwell.com)
  • Gilday DL, Eng B, Paul DJ, et al (1975) Diagnosis of osteomyelitis in children by combined blood pool and bone imaging. (springer.com)
  • Typically, it is the appearance of the bones on an X-ray that signals the physician to make the diagnosis. (rheumatology.org)
  • Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. (worldcat.org)
  • A bone biopsy is often required to determine the actual diagnosis of such a defect. (medscape.com)
  • Provide a general approach to the diagnosis, management, and treatment of patients with a rheumatological, immunological, or allergic disease. (unimi.it)
  • The loss of bone triggers the osteoblasts to rapidly produce more bone in an attempt to replace the extra bone being lost. (mydr.com.au)
  • At the same time, they prevent bone repair by inhibiting the formation of osteoblasts. (myeloma.org)
  • Lee SM, Bae SK, Cho MR (2000) Acute osteomyelitis shown as a cold lesion on bone scan. (springer.com)
  • Physicians usually obtain a non-invasive bone scan to determine the extent of bone involvement. (rheumatology.org)
  • It also predicts if the person requires a special X-ray test called 'bone densitometry or DEXA scan' to confirm the score index from the results of the chart. (medindia.net)
  • You may have a bone scan of your whole body to find out which bones are affected. (healthlinkbc.ca)
  • An otherwise asymptomatic patient whose MRI scan shows more than 1 focal lesion of at least 5 mm in size has what is called a "myeloma-defining event," and should be treated for active disease. (myeloma.org)
  • CT (computed tomography): Current NCCN (National Comprehensive Cancer Network) guidelines list skeletal survey or whole-body low-dose CT scan as the preferred studies for diagnosing myeloma bone disease, giving doctors the choice to do the more sensitive (and more expensive) CT study if insurance reimbursement is available. (myeloma.org)
  • At first I thought for sure it was bone cancer and had a full body bone scan even. (healingwell.com)
  • Approximately 35% of patients with Paget's have symptoms related to the disease when they are first diagnosed. (wikipedia.org)
  • Paget's disease may be caused by a slow virus infection (i.e., paramyxoviridae) present for many years before symptoms appear. (wikipedia.org)
  • Symptoms may include localized bone pain, tenderness, redness and swelling as well as possible fever and chills. (livestrong.com)
  • The man's symptoms, particularly his deformed fingers, are characteristic of a bone disease called skeletal fluorosis , which is caused by consuming too much fluoride. (livescience.com)
  • There is no cure for brittle bone disease, but treatment can relieve symptoms, prevent breakage of bones, and maximize movement. (webmd.com)
  • If symptoms and signs are present, these can include bone pain in the affected area. (rxlist.com)
  • Most people with Paget's disease have no symptoms. (healthlinkbc.ca)
  • Your doctor may prescribe medicine if you have symptoms or if you have no symptoms but you are at risk for other problems from Paget's disease. (healthlinkbc.ca)
  • The symptoms of colitis, such as swelling, anemia, and unhealthy increases in monocytes and neutrophils, (cells that fight infection but exacerbate the excessive swelling in intestines) were reflected in the bone marrow. (futurity.org)
  • The fact that these symptoms are only partially improved by the standard treatment with phosphate - which improves circulating phosphate levels - prompted the researchers to look for local factors within the bone that might be blocking mineralization in these patients. (eurekalert.org)
  • This bone disease does not have any symptoms. (thebody.com)
  • In Australia, about 2-4% of people over the age of 55 will have some degree of Paget's disease, although for most people it will cause no symptoms or major problems. (mydr.com.au)
  • Many people with Paget's disease are unaware they have the condition because they have no symptoms or only mild symptoms. (mydr.com.au)
  • The symptoms of Paget's disease depend on where in the body the abnormal new bone is being produced. (mydr.com.au)
  • Doctors diagnose the stage of the disease by closely watching for symptoms. (nationwidechildrens.org)
  • Symptoms of each type of bone marrow disease will vary according to its severity, but tend to be similar in nature. (livestrong.com)
  • Ruxolitinib effectively controls the symptoms but does not offer a cure, as the malignant stem cell clone is located in the bone marrow and is generally not attacked. (innovations-report.com)
  • Most tumors that arise in the bones are noncancerous. (livestrong.com)
  • Cancerous bone tumors are relatively uncommon with an estimated 3,260 new cases per year, according to a 2017 American Cancer Society report. (livestrong.com)
  • Although increased osteoclastic bone destruction is involved in MM and other tumors involving bone, in contrast to other tumors, once the MM tumor burden exceeds 50% in a local area, osteoblast activity is either suppressed or absent. (nih.gov)
  • Both types of tumors can destroy bone. (nih.gov)
  • Majd M, Frankel RS (1976) Radionuclide imaging in skeletal inflammatory and ischemic disease in children. (springer.com)
  • In contrast to such an established CMC2.24's anti-inflammatory/anti-resorptive activity, it has not yet been determined whether CMC2.24 possesses a potency to restore the pathogenically impaired alveolar bone regeneration in periodontitis. (nova.edu)
  • MICHIGAN STATE (US) - Inflammatory bowel diseases wreak havoc on the digestive tract and a new study reveals that the damage is mirrored in the bone marrow. (futurity.org)
  • It's possible that if we could reduce bone marrow's ability to produce inflammatory cells that we could reduce the severity of colitis and Crohn's disease," says Fraker, who co-authored the study with colleagues Laura McCabe, professor of physiology and radiology, and Mark Trottier, research specialist. (futurity.org)
  • The bone marrow's reactions actually fan the flames of the inflammatory bowel diseases rather than help cure it. (futurity.org)
  • The module of rheumatology, clinical immunology, and allergy tackles the approach to patients with an inflammatory, immune, allergic disease through a multidisciplinary approach based on history, physical examination, laboratory tests, and imaging. (unimi.it)
  • Also, celiac disease is associated with the release of inflammatory cytokines or proteins which increase the rate of bone loss, and may negatively affect bone formation. (osteoporosis.ca)
  • Do the radiological changes of classic ankylosing spondylitis differ from the changes found in the spondylitis associated with inflammatory bowel disease, psoriasis, and reactive arthritis? (bmj.com)
  • Thus, bone is impacted negatively not only by local and systemic inflammatory mediators, but also directly, by alterations affecting myelopoiesis and lineage allocations. (springer.com)
  • But if a person consumes a lot of fluoride, then over time, the fluoride forms crystal deposits on bone, leading to skeletal fluorosis. (livescience.com)
  • A fast colour-changing test that detects fluoride in drinking water could help prevent the crippling bone disease skeletal fluorosis in developing countries, say UK researchers. (reuters.com)
  • Washington D.C. [USA], Nov 14 : A simple colour-changing test to detect fluoride in drinking water could in the future prevent the crippling bone disease, skeletal fluorosis, in developing countries such as India and Tanzania. (newkerala.com)
  • Whilst low amounts of fluoride are beneficial for healthy teeth, high levels of fluoride can weaken bones, leading to skeletal fluorosis. (newkerala.com)
  • While RANKL produced by bacteria-reactive lymphocytes is known to cause osteoclast-mediated pathogenic periodontal bone loss3-6 , molecular mechanism underlying the impaired alveolar bone regeneration in the context of periodontitis remains elusive. (nova.edu)
  • 13 , 14 Mutations in the SQSTM1/p62 gene are therefore a plausible cause of Paget's disease, but it is unclear how germline DNA mutations (present in every osteoclast) cause bone disease that is focal in nature. (mja.com.au)
  • As we grow older, the osteoclast cells removes bone quicker than the osteoblast cells can produce it. (thebody.com)
  • Surprisingly, selective knockout of Fra-2 in the macrophage-osteoclast lineage did not show bone phenotypes in vivo, but isolated progenitor cells failed to differentiate in the absence of additional LIF. (sciencemag.org)
  • Graft-versus-Host disease (GVHD) often occurs after allogeneic bone marrow transplants (BMT). (nationwidechildrens.org)
  • The number of patient who develop acute graft-versus-host disease (GVHD). (clinicaltrials.gov)
  • The number of patient who develop chronic graft-versus-host disease (GVHD). (clinicaltrials.gov)
  • This makes their bones weaker and more brittle than normal bones. (kidshealth.org)
  • This is then followed by the arrival of skeletal cells that develop into chondrocytes (cartilage cells), and are then replaced by intrusive bone. (emaxhealth.com)
  • KYOTO - Scientists from Kyoto University and Hyogo College of Medicine have found that cholesterol-fighting statins might help treat people with rare bone and cartilage diseases via iPS cells made from their own bodies. (japantimes.co.jp)
  • Their research, published Wednesday in the online edition of the British science journal Nature, could help people with skeletal dysplasia, a group of rare diseases that affect skeletal growth through abnormalities in bone and cartilage, particularly types known as thanatophoric dysplasia and achondroplasia. (japantimes.co.jp)
  • Scaffold-Based Delivery of Nucleic Acid Therapeutics for Enhanced Bone and Cartilage Repair. (harvard.edu)
  • Advanced Paget's disease may lead to other medical conditions, including: Osteoarthritis may result from changes in bone shape that alter normal skeletal mechanics. (wikipedia.org)
  • The dysregulation of miRNAs has been implicated in various human diseases such as brain tumor, osteoarthritis, schizophrenia, and breast cancer. (intechopen.com)
  • Osteoarthritis may result from changes in bone shape that alter normal skeletal mechanics. (wikipedia.org)
  • He added: "Other treatments that have worked really well in mice with brittle bones, like bone marrow transplantation, haven't worked as well in humans and are not standard practice as of now. (thedailystar.net)
  • The best known of these isosteogenesis imperfecta which has a prevalence of about one in 10,000 in the United Kingdom.It is caused by abnormalities in collagen, the fibrous protein essential for the mechanicalstrength of bone. (slideshare.net)
  • Collagen is an important building block of bones. (kidshealth.org)
  • They either don't have enough collagen in their bones or have collagen that doesn't work as it should. (kidshealth.org)
  • This approach to the study of disease, referred to as "materiomics" by the lead researcher on the project, Professor Markus Buehler of MIT's Department of Civil and Environmental Engineering, could prove valuable in the study of other diseases "" particularly collagen- and other protein-based diseases "" where a material's behavior and breakdown play a critical role. (redorbit.com)
  • Collagen is a protein in your body that forms and strengthens bones. (webmd.com)
  • CRTAP is one of the proteins that modify newly made collagen into its final form before it is secreted from cells to become part of the structure of bone. (nih.gov)
  • Indicative of the heredity consideration, Paget's disease occurs more commonly in European populations and their descendants. (rheumatology.org)
  • The disease most commonly affects the head of the thighbone, or femoral head. (livestrong.com)
  • People with OI might have bones that break easily, which is why the condition is commonly called brittle bone disease . (kidshealth.org)
  • Less commonly, Paget's disease can affect the heart, because the abnormal new bone needs its own blood supply. (mydr.com.au)
  • Pathogenesis of myeloma bone disease. (nih.gov)
  • The cancer affects a line of cell that begins to replicate non-stop clogging the bone marrow and decreasing production of other cells. (news-medical.net)
  • Rarely, a bone affected by Paget's disease can transform into a malignant bone cancer. (wikipedia.org)
  • Only if cancer is suspected will it be necessary to biopsy the bone to examine it under a microscope. (rheumatology.org)
  • The most common bone cancer is osteosarcoma, which primarily affects children, adolescents and young adults. (livestrong.com)
  • Primary bone cancer also occurs in children. (nih.gov)
  • Could a drug be repurposed for cancer-driven bone disease? (medicalnewstoday.com)
  • An enzyme that blocks bone growth and spurs bone destruction may be a culprit behind cancer-driven bone disease, researchers say. (medicalnewstoday.com)
  • The new approach may let scientists selectively block the bad signals that cause or contribute to disease and enhance good signals that defend the body against cancer and infections such as tuberculosis. (eurekalert.org)
  • Alarmo EL, Kallioniemi A. Bone morphogenetic proteins in breast cancer: dual role in tumourigenesis? (medscape.com)
  • Key statistics about bone cancer. (medscape.com)
  • Available at https://www.cancer.org/cancer/bone-cancer/about/key-statistics.html . (medscape.com)
  • Expression of many miRNAs has been found to be upregulated or downregulated in bone cancer cells compared to normal bone cells. (intechopen.com)
  • Apart from the stem cells the bone marrow contains supporting fibrous tissues as well. (news-medical.net)
  • This test uses invisible electromagnetic energy beams to make images of tissues, bones, and organs. (hopkinsmedicine.org)
  • In addition to this, bone also contains osteocyts, which helps in metabolic exchange with the blood that flows through bone tissues. (hpathy.com)
  • In GVHD, the donor's bone marrow attacks the patient's organs and tissues, making them less able to function well. (nationwidechildrens.org)
  • Drug therapies for peripheral joint disease in psoriatic arthritis: a systematic review," The Journal of Rheumatology , vol. 41, no. 11, pp. 2277-2285, 2014. (hindawi.com)
  • Male C282Y homozygotes with a serum ferritin level of 1000 mg/L or more were more likely to report fatigue, use of arthritis medicines, and a history of liver disease. (uptodate.com)
  • The molecule we studied controls cells linked to bone weakening, but it belongs to a family of proteins implicated in conditions such as rheumatoid arthritis, psoriasis, Crohn's disease and asthma," said first author Julia Warren, an MD/PhD student. (eurekalert.org)
  • B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease," The American Journal of Pathology , vol. 169, no. 3, pp. 987-998, 2006. (hindawi.com)
  • The affected bones show signs of dysregulated bone remodeling at the microscopic level, specifically excessive bone breakdown and subsequent disorganized new bone formation. (wikipedia.org)
  • Bone demineralization in cystic fibrosis: evidence of imbalance between bone formation and degradation. (washington.edu)
  • The doctors involved in the case suspected that their patient's abuse of dust spray may have been at least partly to blame for the rapid bone formation. (livescience.com)
  • Consequently, formation of bone-degrading cells was blocked. (eurekalert.org)
  • The infants and children described in Marini's studies have two defective copies of either CRTAP or P3H1 so that almost no protein is produced, resulting in defective bone formation. (nih.gov)
  • Cecilia Giunta and Marianne Rohrbach, both researchers from the Children's Research Center at the University Children's Hospital Zurich, their teams and colleagues from the USA and Thailand have now detected a new type of brittle-bone disease, identifying two families with a total of eight patients in all. (medicalnewstoday.com)
  • Shortly afterwards, researchers discovered that IFAP syndrome, a group of rare dermatological diseases in humans, is caused by mutations in MBTPS2. (medicalnewstoday.com)
  • The researchers worked with RANKL, a protein that activates cells that dismantle bone. (eurekalert.org)
  • According to the researchers, their ability to do this suggests the approach may help design treatments for other diseases that are controlled by similar mechanisms. (eurekalert.org)
  • Researchers at McGill University and the Federal University of Sao Paulo have identified that osteopontin, a major bone and tooth substrate protein, plays a role in XLH. (eurekalert.org)
  • The study is remarkable in the sense that, by using iPS cells to re-create abnormal body cells, researchers have found the possibility that an existing drug could be used to treat another disease. (japantimes.co.jp)
  • April 11, 2013 - Researchers from the University of California, Davis (UC Davis), have launched a Phase I clinical trial of CD34+ bone marrow stem cells (BMSC) for people with retinal conditions that cause vision loss from ischemia, or loss of blood flow, and cell degeneration. (blindness.org)
  • As the disease often affects people differently, treatments of Paget's disease can vary. (wikipedia.org)
  • Paget's disease affects from 1.5 to 8.0 percent of the population, and is most common in those of British descent. (wikipedia.org)
  • When Paget's disease affects the facial bones, the teeth may become loose. (wikipedia.org)
  • Bone disease affects women and men of all ethnicities, although the risk of bone disease is highest among women. (news-medical.net)
  • PDB affects approximately 1 to 2 percent of white adults aged 55 or older, according to an April 2009 review article published in " Therapeutic Advances in Musculoskeletal Disease . (livestrong.com)
  • The disease is inherited in an X-chromosome-recessive manner and affects men and boys as only they carry a copy of the X chromosome. (medicalnewstoday.com)
  • It may affect just one bone, but it usually affects more than one. (healthlinkbc.ca)
  • Paget's disease predominantly affects the elderly. (mja.com.au)
  • Paget's disease is a treatable condition that affects the bones, mainly in older people. (mydr.com.au)
  • Paget's disease mainly affects older people. (mydr.com.au)
  • XLH is an ultra-rare disease that affects both males and females. (xconomy.com)
  • Weak bones are not a natural part of aging. (news-medical.net)
  • If you don't have enough of it, your bones become very weak and will break easily. (webmd.com)
  • But this new bone is often weak and brittle, and it breaks easily. (healthlinkbc.ca)
  • Bone mineral content in cystic fibrosis patients: correlation with fat-free mass. (washington.edu)
  • The results of this latest research by Drs. McKee and Barros will be published in the March issue of the Journal of Bone and Mineral Research . (eurekalert.org)
  • Our doctors use a wide range of advanced diagnostic techniques to uncover what is causing your bone and/or mineral disease. (tuftsmedicalcenter.org)
  • Patients with chronic renal disease are at risk for developing a complex bone disease known as renal osteodystrophy. (nih.gov)
  • MDS syndromes are classified by how the cells in the bone marrow and blood smear look under the microscope. (news-medical.net)
  • Paget's disease typically occurs in an older population. (rheumatology.org)
  • Osteopenia, it turns out, is a slight thinning of the bones that occurs naturally as women get older and typically doesn't result in disabling bone breaks. (npr.org)
  • Most people who have bone disease don't know it because bone loss generally doesn't hurt and occurs over time. (thebody.com)
  • Acute GVHD most often occurs in the first 100 days after a bone marrow transplant. (nationwidechildrens.org)
  • Bone marrow disease occurs when there is some kind of abnormality or interference with the production of blood cells. (livestrong.com)
  • Bhattacharya used the Human Phenotype Ontology (HPO), a database that links genomic data to the abnormal phenotypes found in human disease, everything from atrial septal defect, or a hole in the chambers of the heart, to musculoskeletal abnormalities. (ucsf.edu)