Bone Diseases: Diseases of BONES.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Bone Diseases, MetabolicBone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Bone Resorption: Bone loss due to osteoclastic activity.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Renal Osteodystrophy: Decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Osteomalacia: Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.Diphosphonates: Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Osteolysis: Dissolution of bone that particularly involves the removal or loss of calcium.Osteoclasts: A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.Bone Development: The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Osteitis Fibrosa Cystica: A fibrous degeneration, cyst formation, and the presence of fibrous nodules in bone, usually due to HYPERPARATHYROIDISM.Osteoblasts: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.Parathyroid Hormone: A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.Osteoporosis: Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.Alkaline Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.Fractures, Bone: Breaks in bones.Bone Matrix: Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.Osteitis Deformans: A disease marked by repeated episodes of increased bone resorption followed by excessive attempts at repair, resulting in weakened, deformed bones of increased mass. The resultant architecture of the bone assumes a mosaic pattern in which the fibers take on a haphazard pattern instead of the normal parallel symmetry.Osteolysis, Essential: Syndromes of bone destruction where the cause is not obvious such as neoplasia, infection, or trauma. The destruction follows various patterns: massive (Gorham disease), multicentric (HAJDU-CHENEY SYNDROME), or carpal/tarsal.Osteogenesis: The process of bone formation. Histogenesis of bone including ossification.Aluminum: A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.RANK Ligand: A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.Bone Regeneration: Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.Ilium: The largest of three bones that make up each half of the pelvic girdle.Bone Density Conservation Agents: Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.Hyperparathyroidism: A condition of abnormally elevated output of PARATHYROID HORMONE (or PTH) triggering responses that increase blood CALCIUM. It is characterized by HYPERCALCEMIA and BONE RESORPTION, eventually leading to bone diseases. PRIMARY HYPERPARATHYROIDISM is caused by parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. SECONDARY HYPERPARATHYROIDISM is increased PTH secretion in response to HYPOCALCEMIA, usually caused by chronic KIDNEY DISEASES.Osteoprotegerin: A secreted member of the TNF receptor superfamily that negatively regulates osteoclastogenesis. It is a soluble decoy receptor of RANK LIGAND that inhibits both CELL DIFFERENTIATION and function of OSTEOCLASTS by inhibiting the interaction between RANK LIGAND and RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B.Dihydrotachysterol: A VITAMIN D that can be regarded as a reduction product of vitamin D2.Hyperparathyroidism, Secondary: Abnormally elevated PARATHYROID HORMONE secretion as a response to HYPOCALCEMIA. It is caused by chronic KIDNEY FAILURE or other abnormalities in the controls of bone and mineral metabolism, leading to various BONE DISEASES, such as RENAL OSTEODYSTROPHY.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Fractures, Spontaneous: Fractures occurring as a result of disease of a bone or from some undiscoverable cause, and not due to trauma. (Dorland, 27th ed)Bone Transplantation: The grafting of bone from a donor site to a recipient site.Osteocalcin: Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.Osteocytes: Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.Bone Diseases, Endocrine: Diseases of the bones related to hyperfunction or hypofunction of the endocrine glands.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Rickets: Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.Bone Morphogenetic Proteins: Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.Bone Substitutes: Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.Hypercalcemia: Abnormally high level of calcium in the blood.Strontium Isotopes: Stable strontium atoms that have the same atomic number as the element strontium, but differ in the atomic weight. Sr-84, 86, 87, and 88 are the stable strontium isotopes.Femur: The longest and largest bone of the skeleton, it is situated between the hip and the knee.Osteonecrosis: Death of a bone or part of a bone, either atraumatic or posttraumatic.Technetium Tc 99m Medronate: A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.Clodronic Acid: A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.Fibrous Dysplasia of Bone: A disease of bone marked by thinning of the cortex by fibrous tissue containing bony spicules, producing pain, disability, and gradually increasing deformity. Only one bone may be involved (FIBROUS DYSPLASIA, MONOSTOTIC) or several (FIBROUS DYSPLASIA, POLYOSTOTIC).Osteopetrosis: Excessive formation of dense trabecular bone leading to pathological fractures; OSTEITIS; SPLENOMEGALY with infarct; ANEMIA; and extramedullary hemopoiesis (HEMATOPOIESIS, EXTRAMEDULLARY).Calcification, Physiologic: Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.Receptor Activator of Nuclear Factor-kappa B: A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It is also expressed on DENDRITIC CELLS where it plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.Tibia: The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.Absorptiometry, Photon: A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.Renal Dialysis: Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.Calcium Metabolism Disorders: Disorders in the processing of calcium in the body: its absorption, transport, storage, and utilization.Bone Morphogenetic Protein 2: A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.Minerals: Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.Pelvic Bones: Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.Potassium Citrate: A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher.Osteosclerosis: An abnormal hardening or increased density of bone tissue.Temporal Bone: Either of a pair of compound bones forming the lateral (left and right) surfaces and base of the skull which contains the organs of hearing. It is a large bone formed by the fusion of parts: the squamous (the flattened anterior-superior part), the tympanic (the curved anterior-inferior part), the mastoid (the irregular posterior portion), and the petrous (the part at the base of the skull).Hydroxycholecalciferols: Hydroxy analogs of vitamin D 3; (CHOLECALCIFEROL); including CALCIFEDIOL; CALCITRIOL; and 24,25-DIHYDROXYVITAMIN D 3.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.Vitamin D: A vitamin that includes both CHOLECALCIFEROLS and ERGOCALCIFEROLS, which have the common effect of preventing or curing RICKETS in animals. It can also be viewed as a hormone since it can be formed in SKIN by action of ULTRAVIOLET RAYS upon the precursors, 7-dehydrocholesterol and ERGOSTEROL, and acts on VITAMIN D RECEPTORS to regulate CALCIUM in opposition to PARATHYROID HORMONE.Jaw DiseasesCollagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.X-Ray Microtomography: X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.Skull: The SKELETON of the HEAD including the FACIAL BONES and the bones enclosing the BRAIN.Parietal Bone: One of a pair of irregularly shaped quadrilateral bones situated between the FRONTAL BONE and OCCIPITAL BONE, which together form the sides of the CRANIUM.Bone Diseases, Infectious: Bone diseases caused by pathogenic microorganisms.Osteogenesis Imperfecta: COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.Technetium Compounds: Inorganic compounds that contain TECHNETIUM as an integral part of the molecule. Technetium 99m (m=metastable) is an isotope of technetium that has a half-life of about 6 hours. Technetium 99, which has a half-life of 210,000 years, is a decay product of technetium 99m.Alendronate: A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.Calcium Carbonate: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.Alveolar Bone Loss: Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.Bone Cements: Adhesives used to fix prosthetic devices to bones and to cement bone to bone in difficult fractures. Synthetic resins are commonly used as cements. A mixture of monocalcium phosphate, monohydrate, alpha-tricalcium phosphate, and calcium carbonate with a sodium phosphate solution is also a useful bone paste.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Ergocalciferols: Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.Osteoporosis, Postmenopausal: Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.Trapidil: A coronary vasodilator agent.Haversian System: A circular structural unit of bone tissue. It consists of a central hole, the Haversian canal through which blood vessels run, surrounded by concentric rings, called lamellae.Bone Cysts: Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.Hypophosphatemia: A condition of an abnormally low level of PHOSPHATES in the blood.Phosphates: Inorganic salts of phosphoric acid.Parathyroid Glands: Two pairs of small oval-shaped glands located in the front and the base of the NECK and adjacent to the two lobes of THYROID GLAND. They secrete PARATHYROID HORMONE that regulates the balance of CALCIUM; PHOSPHORUS; and MAGNESIUM in the body.Mice, Inbred C57BLCalcitriol: The physiologically active form of vitamin D. It is formed primarily in the kidney by enzymatic hydroxylation of 25-hydroxycholecalciferol (CALCIFEDIOL). Its production is stimulated by low blood calcium levels and parathyroid hormone. Calcitriol increases intestinal absorption of calcium and phosphorus, and in concert with parathyroid hormone increases bone resorption.Imidazoles: Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).N-substituted Glycines: AMINO ACIDS composed of GLYCINE substituted at the nitrogen rather than the usual carbon position, resulting in the loss of HYDROGEN BONDING donors. Polymers of these compounds are called PEPTOIDS.Medullary Sponge Kidney: A non-hereditary KIDNEY disorder characterized by the abnormally dilated (ECTASIA) medullary and inner papillary portions of the collecting ducts. These collecting ducts usually contain CYSTS or DIVERTICULA filled with jelly-like material or small calculi (KIDNEY STONES) leading to infections or obstruction. It should be distinguished from congenital or hereditary POLYCYSTIC KIDNEY DISEASES.Nephrolithiasis: Formation of stones in the KIDNEY.Hypocalcemia: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)Mesenchymal Stromal Cells: Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Monoclonal Gammopathy of Undetermined Significance: Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia.Spine: The spinal or vertebral column.Femoral NeoplasmsParathyroidectomy: Excision of one or more of the parathyroid glands.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Frontal Bone: The bone that forms the frontal aspect of the skull. Its flat part forms the forehead, articulating inferiorly with the NASAL BONE and the CHEEK BONE on each side of the face.Core Binding Factor Alpha 1 Subunit: A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.OsteomyelitisAcid Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.2.Bone Morphogenetic Protein 7: A bone morphogenetic protein that is widely expressed during EMBRYONIC DEVELOPMENT. It is both a potent osteogenic factor and a specific regulator of nephrogenesis.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Bone Marrow DiseasesCalcium, Dietary: Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.Radionuclide Imaging: The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.Lumbar Vertebrae: VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.Hyperphosphatemia: A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum.Phosphorus Metabolism Disorders: Disorders in the processing of phosphorus in the body: its absorption, transport, storage, and utilization.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.PHEX Phosphate Regulating Neutral Endopeptidase: A membrane-bound metalloendopeptidase that may play a role in the degradation or activation of a variety of PEPTIDE HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. Genetic mutations that result in loss of function of this protein are a cause of HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT.Cellular Microenvironment: Local surroundings with which cells interact by processing various chemical and physical signals, and by contributing their own effects to this environment.Cathepsin K: A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.Calcinosis: Pathologic deposition of calcium salts in tissues.Receptors, Tumor Necrosis Factor: Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.Hyperparathyroidism, Primary: A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.Maxillary DiseasesLeg Bones: The bones of the free part of the lower extremity in humans and of any of the four extremities in animals. It includes the FEMUR; PATELLA; TIBIA; and FIBULA.Acidosis, Renal Tubular: A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.Bone Marrow Neoplasms: Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.Bone Marrow Examination: Removal of bone marrow and evaluation of its histologic picture.Femoral Fractures: Fractures of the femur.Metacarpal Bones: The five cylindrical bones of the METACARPUS, articulating with the CARPAL BONES proximally and the PHALANGES OF FINGERS distally.Boronic Acids: Inorganic or organic compounds that contain the basic structure RB(OH)2.Vitamin D Deficiency: A nutritional condition produced by a deficiency of VITAMIN D in the diet, insufficient production of vitamin D in the skin, inadequate absorption of vitamin D from the diet, or abnormal conversion of vitamin D to its bioactive metabolites. It is manifested clinically as RICKETS in children and OSTEOMALACIA in adults. (From Cecil Textbook of Medicine, 19th ed, p1406)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Hypophosphatasia: A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)Bone Morphogenetic Protein 4: A bone morphogenetic protein that is a potent inducer of bone formation. It also functions as a regulator of MESODERM formation during EMBRYONIC DEVELOPMENT.Breast Neoplasms: Tumors or cancer of the human BREAST.Metatarsal Bones: The five long bones of the METATARSUS, articulating with the TARSAL BONES proximally and the PHALANGES OF TOES distally.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Tarsal Bones: The seven bones which form the tarsus - namely, CALCANEUS; TALUS; cuboid, navicular, and the internal, middle, and external cuneiforms.Receptors, Cytoplasmic and Nuclear: Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.Receptors, CCR1: CCR receptors with specificity for a broad variety of CC CHEMOKINES. They are expressed at high levels in MONOCYTES; tissue MACROPHAGES; NEUTROPHILS; and EOSINOPHILS.Parathyroid Hormone-Related Protein: A ubiquitously expressed, secreted protein with bone resorption and renal calcium reabsorption activities that are similar to PARATHYROID HORMONE. It does not circulate in appreciable amounts in normal subjects, but rather exerts its biological actions locally. Overexpression of parathyroid hormone-related protein by tumor cells results in humoral calcemia of malignancy.Dihydroxycholecalciferols: Cholecalciferols substituted with two hydroxy groups in any position.Technetium: The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Bone Demineralization Technique: Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.Foot Bones: The TARSAL BONES; METATARSAL BONES; and PHALANGES OF TOES. The tarsal bones consists of seven bones: CALCANEUS; TALUS; cuboid; navicular; internal; middle; and external cuneiform bones. The five metatarsal bones are numbered one through five, running medial to lateral. There are 14 phalanges in each foot, the great toe has two while the other toes have three each.Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Spinal DiseasesLow Density Lipoprotein Receptor-Related Protein-5: LDL-receptor related protein that combines with FRIZZLED RECEPTORS at the cell surface to form receptors that bind WNT PROTEINS. The protein plays an important role in the WNT SIGNALING PATHWAY in OSTEOBLASTS and during EMBRYONIC DEVELOPMENT.PyrazinesHypophosphatemia, Familial: An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Mice, SCID: Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.Radius: The outer shorter of the two bones of the FOREARM, lying parallel to the ULNA and partially revolving around it.Orthopedics: A surgical specialty which utilizes medical, surgical, and physical methods to treat and correct deformities, diseases, and injuries to the skeletal system, its articulations, and associated structures.Procollagen: A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.Bone Cysts, Aneurysmal: Fibrous blood-filled cyst in the bone. Although benign it can be destructive causing deformity and fractures.Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Ovariectomy: The surgical removal of one or both ovaries.Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.Bone Morphogenetic Protein 6: A bone morphogenetic protein that is a potent inducer of BONE formation. It plays additional roles in regulating CELL DIFFERENTIATION of non-osteoblastic cell types and epithelial-mesenchymal interactions.Calcifediol: The major circulating metabolite of VITAMIN D3. It is produced in the LIVER and is the best indicator of the body's vitamin D stores. It is effective in the treatment of RICKETS and OSTEOMALACIA, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Chondrocalcinosis: Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Bone Plates: Implantable fracture fixation devices attached to bone fragments with screws to bridge the fracture gap and shield the fracture site from stress as bone heals. (UMDNS, 1999)Osseointegration: The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).Periosteum: Thin outer membrane that surrounds a bone. It contains CONNECTIVE TISSUE, CAPILLARIES, nerves, and a number of cell types.Macrophage Colony-Stimulating Factor: A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).

Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions: a randomized, placebo-controlled trial. Protocol 18 Aredia Breast Cancer Study Group. (1/1036)

PURPOSE: To assess whether pamidronate can reduce the frequency of skeletal morbidity in women with lytic bone metastases from breast cancer treated with hormone therapy. PATIENTS AND METHODS: Three hundred seventy-two women with breast cancer who had at least one lytic bone lesion and who were receiving hormonal therapy were randomized to receive 90 mg of pamidronate or placebo as a 2-hour intravenous infusion given in double-blind fashion every 4 weeks for 24 cycles. Patients were evaluated for skeletal complications: pathologic fractures, spinal cord compression, irradiation of or surgery on bone, or hypercalcemia. The skeletal morbidity rate (the ratio of the number of skeletal complications to the time on trial) was the primary efficacy variable. Bone pain, use of analgesics, quality of life, performance status, bone tumor response, and biochemical parameters were also evaluated. RESULTS: One hundred eighty-two patients who received pamidronate and 189 who received placebo were assessable. The skeletal morbidity rate was significantly reduced at 12, 18, and 24 cycles in patients treated with 90 mg of pamidronate (P = .028, .023, and .008, respectively). At 24 cycles, the proportion of patients having had any skeletal complication was 56% in the pamidronate group and 67% in the placebo group (P = .027). The time to the first skeletal complication was longer for patients receiving pamidronate than for those given placebo (P = .049). There was no statistical difference in survival or in objective bone response rate. Pamidronate was well tolerated. CONCLUSION: Treatment with 90 mg of pamidronate as a 2-hour intravenous infusion every 4 weeks in addition to hormonal therapy significantly reduces skeletal morbidity from osteolytic metastases.  (+info)

The aetiology of congenital angulation of tubular bones with constriction of the medullary canal, and its relationship to congenital pseudarthrosis. (2/1036)

It is suggested that there is a group of cases of congenital angulation of tubular bones in which the lesion is a defect of ossification of the primary cartilaginous anlage and in which neurofibromatosis is not implicated. It appears that in this group the prognosis with regard to the resolution of deformity and the prevention of pseudarthrosis with conservative treatment or relatively simple surgical procedures is better than that in the neurofibromatous type.  (+info)

Massive pelvic and femoral pseudotumoral osteolysis secondary to an uncemented total hip arthroplasty. (3/1036)

A 51 year-old man developed an extensive osteolytic response to wear debris in an uncemented porous-coated total hip arthroplasty, with metal/polyethylene interface, which had been implanted eighteen years previously. This reaction, which involved the upper femur and the ilium, produced a mass which compressed the pelvic viscera.  (+info)

Circulating biochemical markers of bone remodeling in uremic patients. (4/1036)

Chronic renal failure is often associated with bone disorders, including secondary hyperparathyroidism, aluminum-related low-turnover bone disease, osteomalacia, adynamic osteopathy, osteoporosis, and skeletal beta2-microglobulin amyloid deposits. In spite of the enormous progress made during the last few years in the search of noninvasive methods to assess bone metabolism, the distinction between high- and low-turnover bone diseases in these patients still frequently requires invasive and/or costly procedures such as bone biopsy after double tetracycline labeling, scintigraphic-scan studies, computed tomography, and densitometry. This review is focused on the diagnostic value of several new serum markers of bone metabolism, including bone-specific alkaline phosphatase (bAP), procollagen type I carboxy-terminal extension peptide (PICP), procollagen type I cross-linked carboxy-terminal telopeptide (ICTP), pyridinoline (PYD), osteocalcin, and tartrate-resistant acid phosphatase (TRAP) in patients with chronic renal failure. Most of the observations made by several groups converge to the conclusion that serum bAP is the most sensitive and specific marker to evaluate the degree of bone remodeling in uremic patients. Nonetheless, PYD and osteocalcin, in spite of their retention and accumulation in the serum of renal insufficient patients, are also excellent markers of bone turnover. The future generalized use of these markers, individually or in combination with other methods, will undoubtedly improve the diagnosis and the treatment of the complex renal osteodystrophy.  (+info)

Cladribine activity in adult langerhans-cell histiocytosis. (5/1036)

Langerhans-cell histiocytosis (LCH) results from the accumulation of tissue histiocytes derived from the same progenitor cells as monocytes. Because cladribine is potently toxic to monocytes, we conducted a phase II trial of cladribine. Cladribine was administered to 13 LCH patients at 0.14 mg/kg per day by 2-hour intravenous infusion for 5 consecutive days, every 4 weeks for a maximum of six courses. Median age was 42 years (range, 19 to 72) and median pretreatment disease duration was 99 months (range, 6 to 252). One patient was untreated, one had received prior prednisone only, one prior radiation only, six prior radiation and chemotherapy, and four prior surgery, radiation, and chemotherapy. Seven patients had cutaneous involvement, six multifocal osseous, six pulmonary, two each with soft tissue and nodal involvement, and four had diabetes insipidus. Of 13 patients, 12 were evaluable for response and all for toxicity. After a median of three courses (range, 1 to 6), seven (58%) patients achieved complete responses (two pathologic and five clinical) and two (17%) patients achieved partial responses; overall response rate, 75%. Median response follow-up duration was 33 months (range, 1 to 65). Seven patients experienced grade 3 to 4 neutropenia. Only one patient had a documented infection, dermatomal herpes zoster. At a median follow-up of 42 months (range, 5 to 76), 12 patients remain alive and one patient has died. Thus, cladribine has major activity in adult LCH and warrants further investigation in both pediatric and adult LCH as a single agent and in combination with other drugs.  (+info)

Osteoblast-specific gene expression after transplantation of marrow cells: implications for skeletal gene therapy. (6/1036)

Somatic gene therapies require targeted transfer of the therapeutic gene(s) into stem cells that proliferate and then differentiate and express the gene in a tissue-restricted manner. We have developed an approach for gene therapy using marrow cells that takes advantage of the osteoblast specificity of the osteocalcin promoter to confine expression of chimeric genes to bone. Adherent marrow cells, carrying a reporter gene [chloramphenicol acetyltransferase (CAT)] under the control of a 1.7-kilobase rat osteocalcin gene promoter, were expanded ex vivo. After transplantation by intravenous infusion, engrafted donor cells in recipient mice were detected by the presence of the transgene in a broad spectrum of tissues. However, expression of the transgene was restricted to osteoblasts and osteocytes, as established by biochemical analysis of CAT activity and immunohistochemical analysis of CAT expression at the single cell level. Our data indicate that donor cells achieved long-term engraftment in various tissues of the recipients and that the CAT gene under control of the osteocalcin promoter is expressed specifically in bone. Thus, transplantation of multipotential marrow cells containing the osteocalcin promoter-controlled transgene provides an efficacious approach to deliver therapeutic gene expression to osteoblasts for treatment of bone disorders or tumor metastasis to the skeleton.  (+info)

Beta2-microglobulin and renal bone disease. (7/1036)

Dialysis-related amyloidosis (DRA) is characterized by amyloid deposition mainly in bone and joint structures, presenting as carpal tunnel syndrome, destructive arthropathy, and subchondral bone erosions and cysts. Beta2-microglobulin has been demonstrated to be a major constituent of amyloid fibrils. DRA occurs not only in patients undergoing long-term hemodialysis, but also in patients undergoing continuous ambulatory peritoneal dialysis. The incidence of this complication increases with the duration of dialytic therapy and the age of the patient. While a definitive diagnosis of DRA can be made only by histological findings, various imaging techniques often support diagnosis. The molecular pathogenesis of this complication remains unknown. Recent studies have, however, suggested a pathogenic role of a new modification of beta2-microglobulin in amyloid fibrils--that is, the advanced glycation end-products (AGEs) formed with carbonyl compounds derived from autoxidation of both carbohydrates and lipids ("carbonyl stress"). Therapy for DRA is limited to symptomatic approaches and surgical removal of amyloid deposits. High-flux biocompatible dialysis membranes could be used to delay DRA development.  (+info)

Prostaglandins and bone: physiology and pathophysiology. (8/1036)

Prostaglandins (PGs) are potent stimulators of bone formation and resorption and are produced by bone cells. PGs also have inhibitory effects on fully differentiated osteoblasts and osteoclasts. This complex, multifunctional regulation is probably mediated by different PG receptors. Endogenous PGs in bone are produced largely by induction of COX-2, which is highly regulated by hormones and local factors. The development of specific agonists and antagonists for PG receptors and for COX-2 should allow us to define the physiologic and pathophysiologic roles of PGs more precisely and develop new therapeutic approaches to metabolic and inflammatory disorders of the skeleton.  (+info)

*Bone disease

... refers to the medical conditions which affect the bone. A bone disease is also called an "osteopathy", but because ... or Paget's disease of bone) Osteitis fibrosa cystica (or Osteitis fibrosa, or Von Recklinghausen's disease of bone) Osteitis ... of bone Greenstick Fracture Gout Hypophosphatasia Hereditary multiple exostoses Klippel-Feil syndrome Metabolic Bone Disease ... Osteochondrodysplasia is a general term for a disorder of the development of bone and cartilage. Ambe Avascular necrosis or ...

*Infectious bone disease

An infectious bone disease is a bone disease primarily associated with an infection. An example is osteomyelitis. Root, Richard ... K. (1999). Clinical Infectious Diseases: A Practical Approach. Oxford University Press. p. 741. ISBN 9780195081039. Retrieved 5 ...

*Endocrine bone disease

An endocrine bone disease is a bone disease associated with a disorder of the endocrine system. An example is osteitis fibrosa ... There are many bone disorders such as osteoporosis, Paget's disease, hypothyroidism. Although there are many forms of bone ... The cells of our bone that is involved in bone formation and bone breakdown is osteoblast and osteoclast respectively. ... Osteoclasts are cells of bones that promote bone demineralization or bone resorption. In contrast, Osteoblast promotes calcium ...

*Metabolic bone disease

... of metabolic bone disease Metabolic Bone Disease Squirrel Wildlife Rehabilitators-Metabolic Bone Disease Metabolic Bone Disease ... Metabolic bone disease is an umbrella term referring to abnormalities of bones caused by a broad spectrum of disorders. Most ... osteoporosis osteomalacia (adults) & rickets (children) osteitis fibrosa cystica Paget's disease of bone pyramiding (turtles) ... These disorders are to be differentiated from a larger group of genetic bone disorders where there is a defect in a specific ...

*Bone Disease Program of Texas

... was the founding director of the Bone Disease Program of Texas. The current director (2007) of the Bone Disease Program of ... The Bone Disease Program of Texas is defined by a contractual relationship among Baylor College of Medicine, M.D. Anderson ... The Rolanette and Berdon Lawrence Bone Disease Program of Texas (RBL BDPT) is a collaborative program that includes the Baylor ... The program was established in 2002 by the two academic institutions to focus on osteoporosis and other Metabolic Bone Disease ...

*Paget's disease of bone

... and does not spread from bone to bone. Rarely, a bone affected by Paget's disease can transform into a malignant bone cancer. ... Ethel, SS; Roodman, GD (2008). "Paget's disease of bone". In Rosen. Primer on the metabolic bone diseases and disorders of ... Paget's Disease of Bone Overview - NIH Osteoporosis and Related Bone Diseases ~ National Resource Center. ... Bone scans are useful in determining the extent and activity of the condition. If a bone scan suggests Paget's disease, the ...

*Chronic kidney disease-mineral and bone disorder

... (NIDDKD) Overview of chronic kidney disease-mineral bone disease (CKD-MBD) ( ... bone modeling) and bone structure and function during adulthood (bone remodeling). As a result, bone abnormalities are found ... Kidney Disease: Improving Global Outcomes ERA-EDTA WORKING GROUP ON CHRONIC KIDNEY DISEASE AND MINERAL BONE DISORDER (CKD-MBD) ... Chronic kidney disease-mineral bone diorder (RenalMed) Current Concepts and Management Strategies in Chronic Kidney Disease- ...

*Bone destruction patterns in periodontal disease

In periodontal disease, not only does the bone that supports the teeth, known as alveolar bone, reduce in height in relation to ... Horizontal bone loss manifests as a somewhat even degree of bone resorption so that the height of the bone in relation to the ... The bone destruction patterns that occur as a result of periodontal disease generally take on characteristic forms. There are ... Carranza, FA: Bone Loss and Patterns of Bone Destruction. In Newman, MG; Takei, HH; Carranza, FA; editors: Carranza's Clinical ...

*Marrow adipose tissue

Metabolic Bone Disease and Related Research. 4 (1): 69-75. doi:10.1016/0221-8747(82)90011-X. Rubin, M. R.; Manavalan, J. S.; ... "Bone marrow fat accumulation accelerated by high fat diet is suppressed by exercise". Bone. 64: 39-46. doi:10.1016/j.bone. ... reduced bone mineral density, and an altered osteoblast differentiation program". Bone. 35 (5): 1046-1058. doi:10.1016/j.bone. ... high-fat diets induces low bone mineral density and reduces bone formation in rats". Journal of Bone and Mineral Research. 25 ( ...

*Vertebral compression fracture

Weber, Kristy (February 28, 2006). "Rounds 2: Treatment of Metastatic Bone Disease". Johns Hopkins Arthritis Center. "Bone ... In addition, bone density measurement may be performed to evaluate for osteoporosis. When a tumor is suspected as the ... Compression fracture of T12 Back brace for support while the bone heals-either a Jewett brace for relatively stable and mild ... ISBN 978-0-7817-6135-2. Freedman, B. A.; Heller, J. G. (2009). "Kummel Disease: A Not-So-Rare Complication of Osteoporotic ...

*Green iguana in captivity

... the iguana develops Metabolic Bone Disease (MBD). Metabolic Bone Disease causes soft bones, stunted growth, permanent bone ... and subsequently will develop metabolic bone disease which is fatal if not treated. In some locales, iguanas are considered ... "Identification and treatment of metabolic bone disease". Melissa Kaplan's Herp Care Collection. anapsid.org. Retrieved 2007-06- ... deformities, frequent broken bones, loss of limbs and ultimately, death. Although they will consume a wide variety of foods if ...

*Radiographic classification of osteoarthritis

Page 117 in Barbara N. W. Weissman (2009). Imaging of Arthritis and Metabolic Bone Disease. Elsevier Health Sciences. ISBN ... The distances between the bones in the ankle are normally as follows: Talus - medial malleolus : 1.70 ± 0.13 mm Talus - tibial ... "Osteoarthritis Classification Scales: Interobserver Reliability and Arthroscopic Correlation". The Journal of Bone and Joint ... but most of the span of the Ahlbäck system focused at various degrees of bone defect or loss, and it is therefore less useful ...

*KV21

"King Tut Felled by Malaria, Bone Disease." Discovery News, February 16, 2010. Retrieved from http://news.discovery.com/ ...

*Polyuria

Imaging of arthritis and metabolic bone disease. Philadelphia, PA: Mosby/Elsevier. p. 679. ISBN 978-0-323-04177-5. Retrieved 5 ... Polyuria is usually viewed as a symptom or sign of another disorder (not a disease by itself), but it can be classed as a ... Mariani, Laura (2007). "The Renal Manifestations of Thyroid Disease". Journal of the American society of Nephrology: 22-26. ... hyperthyroidism hypopituitarism Conn's disease hyperglycaemia Circulation congestive heart failure Cardiorespiratory disease ...

*Coxa vara

Other common causes include metabolic bone diseases (e.g. Paget's disease of bone), post-Perthes deformity, osteomyelitis, and ... It can also occur when the bone tissue in the neck of the femur is softer than normal, causing it to bend under the weight of ... This may either be congenital or the result of a bone disorder. The most common cause of coxa vara is either congenital or ... Faulty maturation of the cartilage and metaphyseal bone of the femoral neck. Clinical feature: presents after the child has ...

*Senior dog diet

"Calcium and Vitamin D: Important at Every Age , NIH Osteoporosis and Related Bone Diseases National Resource Center". www.bones ... This can lead to bone weakening and the inability to repair bone damage. Beet pulp is a common ingredient in dog diets as it is ... The reduction of this cushion in the joints causes bone-on-bone contact to occur, causing the animal great discomfort. This can ... This can help aging joints by maintaining the cartilage, thus reducing the pain caused by bone-on-bone contact within the joint ...

*Giant Schnauzer

Bone diseases and joint problems are also an issue. The most common causes of death in Giant Schnauzers are lymphoma and liver ... They are also prone to skin diseases, such as seasonal flank alopecia, vitiligo, and follicular cysts. Cancer of the skin is ... ISBN 978-0-7566-4978-4. Gough, Alex; Thomas, Alison (2004). Breed Predispositions to Disease in Dogs and Cats. Blackwell ...

*TwinsUK

ISBN 978-1-4649-6433-6. Bone Diseases: Advances in Research and Treatment: 2011 Edition. ScholarlyEditions. 9 January 2012. p. ... ages 16 to 98 to study the genetic and environmental aetiology of age related complex traits and diseases. Established in 1993 ...

*Primidone

In any case, the use of more than one anticonvulsant has been associated with an increased prevalence of bone disease in ... Harrington, M. G.; H. M. Hodkinson (July 1987). "Anticonvulsant drugs and bone disease in the elderly". Journal of the Royal ... Primidone, along with phenytoin and phenobarbital, is one of the anticonvulsants most heavily associated with bone diseases ... Dupuytren's contracture, a disease of the fasciae in the palm and fingers that permanently bends the fingers (usually the ...

*Alfacalcidol

"Alfacalcidol in the therapy of renal bone disease". Int J Clin Pharmacol Ther. 39: 546-50. Dec 2001. doi:10.5414/cpp39546. PMID ... It is the most commonly prescribed vitamin D metabolite for patients with end stage renal disease, given that impaired renal ... "Biological effects of various regimes of 25-hydroxyvitamin D3 (calcidiol) administration on bone mineral metabolism in ... Alfacalcidol treatment restores derailed immune-regulation in patients with undifferentiated connective tissue disease, ...

*Liver function tests

GGT is typically not elevated with bone disease. Combined elevations of ALP and GGT are compatible with biliary tract disease. ... ALP is elevated: 1) in children 2- to 3-fold over adults because the child's skeleton is growing, 2) with bone disease ... Most liver diseases cause only mild symptoms initially, but these diseases must be detected early. Hepatic (liver) involvement ... ALP is also present in bone and placental tissue, so it is higher in growing children (as their bones are being remodelled) and ...

*Gaucher's disease

Skeletal weakness and bone disease may be extensive. Spleen enlargement and bone marrow replacement cause anemia, ... Sphingolipidoses Niemann-Pick disease Fabry disease Tay-Sachs disease Krabbe disease Metachromatic leukodystrophy Medical ... Gaucher's disease is the most common of the lysosomal storage diseases. It is a form of sphingolipidosis (a subgroup of ... Type II Gaucher's disease shows no particular preference for any ethnic group. Type III Gaucher's disease is especially common ...

*Leptin

There is a potential for treatment of diseases of bone formation - such as impaired fracture healing - with leptin. Factors ... Bone metabolism can be regulated by central sympathetic outflow, since sympathetic pathways innervate bone tissue. A number of ... Leptin can affect bone metabolism via direct signalling from the brain. Leptin decreases cancellous bone, but increases ... This "cortical-cancellous dichotomy" may represent a mechanism for enlarging bone size, and thus bone resistance, to cope with ...

*Pogona

... metabolic bone disease, atadenovirus, and paralysis. Metabolic bone disease (MBD) is a common disease that can be fatal for ... Hypocalcemia is most often tied to metabolic bone disease. Low levels of calcium can result in twitching muscles, or seizures. ... Bearded dragons require UVB to help enable D3 synthesis and to prevent metabolic bone disease. Bearded dragons also require UVA ... Maintaining a diet which consists of enough calcium is crucial to avoiding hypocalcemia as well as metabolic bone disease. ...

*Primary hyperparathyroidism

"Bones" refers to bone-related complications. The classic bone disease in hyperparathyroidism is osteitis fibrosa cystica, which ... Other bone diseases associated with hyperparathyroidism are osteoporosis, osteomalacia, and arthritis. "Abdominal groans" ... and bone disease. The diagnosis is initially made on blood tests; an elevated level of calcium together with a raised level of ... The symptoms of the disease, listed above, are indications for surgery. Surgery reduces all cause mortality as well as ...

*Atrioventricular node

BMP (Bone morphogenetic protein) cell signaling plays a key role in diverse aspects of cardiac differentiation and ... Atrioventricular conduction disease (AV block) describes impairment of the electrical continuity between the atria and ... ISBN 0-7216-0240-1. Benson DW (October 2004). "Genetics of atrioventricular conduction disease in humans". The Anatomical ... seen in BMP and Alk3 are associated with some cardiovascular diseases like Ebstein's anomaly and AV conduction disease. The AV ...
Treatment of Myeloma Bone Disease James R. Berenson, MD Medical & Scientific Director Institute for Bone Cancer & Myeloma Research West Hollywood, CA Clinical Consequences of Myeloma Bone Disease Pathological
Bone disease: Bone disease, any of the diseases or injuries that affect human bones. Diseases and injuries of bones are major causes of abnormalities of the human skeletal system. Although physical injury, causing fracture, dominates over disease, fracture is but one of several common causes of bone disease, and
Bone Diseases Essay, Research Paper Bone diseases most directly influence the ability to walk or to move any part of the body-hands, limbs, neck, and spine. They are
This study will look to see if there are changes in the blood cells that are associated with bone disease and sort out effects that are due to the HIV virus itself, the medications and see if faster aging occurs in the cells of HIV infected persons. Bone disease will be measured by a special X-ray called a DEXA scan. A DEXA scan is used by doctors to see if someone has normal bone mass for their age or if there is thinning of the bones.. The purposes of this study are:. ...
HD Bone Diseases App is simply a source of information about the human musculoskeletal system and some of its diseases/conditions. The facts are well presented in clear sections with eye-catching pictures and pitched at a level which most will find easy to follow. A number of historical facts about conditions are included which makes interesting reading. There is an excellent section on osteoporosis, explaining the cause, investigations and treatments. The other two sections focus on certain bone diseases - these are explained well with lots of detailed information, but the list of conditions covered is far from comprehensive ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Journal of Osteoporosis is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working on the diagnosis, prevention, treatment and management of osteoporosis and other metabolic bone diseases. The journal publishes research articles, review articles, as well as clinical studies related to the biology, physiology, and pathology of bone and muscle.
What is bone disease and how does it develop in children? Childhood and adolescence are crucial years for the accrual of minerals necessary for bone health. Appropriate accumulation of these minerals (calcium, phosphorous and magnesium) in the bone help the body reach an optimal peak bone mass in young adulthood and decrease the likelihood of osteoporosis in old age.
So change your daily routine before you have to look for the best orthopedic hospitals in Mumbai.. Injuries: Dont neglect your joint or bone injuries. You may accidentally hurt your knees or joints or otherwise. But even after applying pain relieving cream or ice pack over the area if the pain sustains, then dont waste much time but consult an orthopedic doctor right away.. Diet: Fast food is a big no no if you want to stay healthy in every possible means. You have to have a very healthy and heavy protein rich breakfast. Green leafy vegetables, fish, meat and eggs should be there in your diet. Pulses and nuts should be there as well. Bone diseases are caused due to calcium deficiency. So try to have protein enriched food.. What to do next: If you are having pain in your joints or any bone related problems then do look for orthopedic doctors in the town. Take the help of the internet and research about the doctors and the hospitals they are associated with. In doing so dont stick to one ...
Osteoporosis bone disease literally means bones with holes. It occurs when bones lose minerals such as calcium more quickly than the body can replace them
What is bone disease? Why do people with HIV appear to be especially at risk? What are the signs you might be developing bone problems? In this new ...
Dogs of all ages can limp for a variety of reasons, one being bone disease. With a variety of causes and symptoms, usually associated with appearing sore and tired, it is best to contact your veterinarian for treatment options.
Pathogenesis of Bone Diseases: The Role of Immune System. . Download books free in pdf. Online library with books, university works and thousands of documents available to read online and download.
Learn about the veterinary topic of Noninfectious Skeletal Disorders in Broilers. Find specific details on this topic and related topics from the Merck Vet Manual.
This is your stop for learning resources, extra info and essential dates and documents. Ive scoured the world just to bring you, the A Level biologists, all you need to succeed and enjoy your Biology A Level.
Poor nutrition at any point in a dogs life can lead to chronic conditions like obesity, skeletal diseases and even a shorter life span. In the video
Bone disease - Metabolic bone disease: The normal function of bone requires an adequate supply of amino acids (the building blocks for proteins) for the synthesis of collagen, the chief component of the organic matrix; of calcium and phosphate for mineralization of the organic matrix; and of other organic compounds and mineral elements. Also, growth, repair, and remodeling of the bone tissue require a precisely regulated supply of hormones, vitamins, and enzymes. Skeletal disease, when it is due to inadequacies in the supply or action of the above essentials, associated with abnormalities outside the skeleton, is termed metabolic; in such cases the entire skeleton is affected.
TY - JOUR. T1 - A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma. AU - Noonan, Kimberly. AU - Marchionni, Luigi. AU - Anderson, Judy. AU - Pardoll, Drew. AU - Roodman, G. David. AU - Borrello, Ivan. PY - 2010/11/4. Y1 - 2010/11/4. N2 - Osteoclast (OC)-mediated lytic bone disease remains a cause of major morbidity in multiple myeloma. Here we demonstrate the critical role of interleukin-17-producing marrow infiltrating lymphocytes (MILs) in OC activation and development of bone lesions in myeloma patients. Unlike MILs from normal bone marrow, myeloma MILs possess few regulatory T cells (Tregs) and demonstrate an interleukin-17 phenotype that enhances OC activation. In univariate analyses of factors mediating bone destruction, levels of cytokines that selectively induce and maintain the Th17 phenotype tightly correlated with the extent of bone disease in myeloma. In contrast, MILs activated under conditions that skew toward a Th1 phenotype ...
The Metabolic Bone Diseases Clinic at Tufts Medical Center in Boston provides care to manage increased risk for fragility fractures due to bone diseases, like osteoporosis.
The Lawrence Research Competition was established in 2006 to provide seed grants of $45,000 each to two promising investigators in metabolic or metastatic bone disease. Eligible projects include those that study bone metastases, bone health in cancer patients, bone formation, and bone biology. Through mechanisms such as the Rolanette and Berdon Lawrence Bone Research Awards, the Bone Disease Program reaffirms its commitment to fostering groundbreaking research and supporting talented, young investigators in bone research careers ...
ASBMR (2008) Chapter 42. Genetics of Osteoporosis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470623992.ch42 ...
Osteoporosis and other bone diseases, such as Pagets disease and osteogenesis imperfecta, can lead to a downward spiral in physical health and quality of life including losing the ability to walk, stand, and dress. It can even lead to premature death. Weak bones can result in painful and debilitating fractures. Each year, 1.5 million Americans suffer a fracture because of weak bones. The most common breaks are of the wrist, spine and hip.. Hip fractures are by far the most devastating type of broken bone and account for almost 300,000 hospitalizations each year. Of hip-fracture patients: 20 percent die within a year of the fracture, and 20 percent end up in a nursing home within a year. Many become isolated, depressed or afraid to leave home because they fear falling.. Bone disease is costly for society and individuals with the disease. In the United States, care for bone fractures from osteoporosis costs nearly $18 billion each year. The cost from a hip fracture for one individual can be more ...
In recent years there has been an increase in the diagnosis of Metabolic Bone disease in hedgehogs and it is a life-threatening syndrome. While the
This finding brings up important questions for further research," said Dr. Brendan Lee, professor of molecular and human genetics at BCM and corresponding author of the report. "What happens if you make higher levels of the protein associated with WNT1? Can you use this protein as a biomarker in blood for the status of bone formation?". Lee and his colleagues came to this study with a long history of studying diseases that result in brittle bones. They and others have known for a long time that most families with children who had the genetic brittle bone disease osteogenesis imperfecta (OI) often carry mutations in type I collagen, the most abundant protein in bone.. However, in 2006, their work on families with unknown causes of brittle bone diseases led to the discovery of the first new genes for the disease in over two decades. This has since led to a string of discoveries by them and others on how genes in connective tissues control bone growth. In this, perhaps their most surprising ...
Unless closely monitored, renal bone disease (renal osteodystrophy) is a problem that will be experienced by most people suffering from end stage renal disease (ESRD). Renal bone disease is a complex issue and involves many more factors than can be listed in this limited space. Only the very basics are outlined here. First, the kidneys are involved in the synthesis of vitamin D, which is the most essential factor regulating intestinal absorption of calcium in humans. When the kidneys fail and less vitamin D is created, the amount of calcium absorbed by the intestines is reduced. Calcium is most essential substance for bone maintenance and health. Next, calcium and phosphorus levels in the blood (which are normally regulated by the kidneys) are dependent upon each other. Therefore, when the kidneys fail and the phosphorus level in the blood goes up, the (free) calcium level in the blood decreases. In response to these two factors that lower serum calcium, the body then increases the parathyroid ...
Symptoms of lytic bone lesions vary since many different diseases can cause them. Typical symptoms include pain, pathologic bone fractures and high blood calcium, according to MedicineNet. Pathologic...
Metastatic bone disease arises from the spread of certain cancers to the skeletal system. The sarcoma care team assesses impending fracture and coordinates care.
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The method of laser osteoperforation was developed in experiment and then applied for treatment of 508 patients with osteomyelitis, 51 patients with nonunion and pseudo-joint and 34 patients with different forms of osteochondropathy. The clinical trial proved the efficiency of laser osteoperforation for treatment of both inflammatory and destructive bone diseases. This method is minimally invasive, promotes rapid reduction of bone and soft tissue inflammation, and apparently stimulates bone reparation ...
A growth of osteoclasts is inhibited by orally administering a liposomal lactoferrin. Thus a bone disease in which the osteoclast is involved is effectively prevented or treated by orally administerin
OBJECTIVES Identify main functions of bone tissue Identify the major parts of a long bones Describe the cells found in bone tissue Describe the components of an osteon Compare and contrast intramembranous and endochondral ossification.
Dr. Bart Williams is Director of the Center for Cancer and Cell Biology and Professor for the Program in Skeletal Disease and Tumor Microenvironment at the Van Andel Research Institute (VARI).. Dr. Williams research focuses on understanding how alterations in the Wnt signaling pathway cause human disease. A specific focus of his lab is characterizing the role of Wnt signaling in bone formation during normal development and in the face of some common tumor types (for example, prostate, breast, lung, and renal tumors) that metastasize to and grow in bone. The Williams Lab has developed many valuable genetic models of bone disease including osteoarthritis and fracture repair and is working towards identifying novel genes that play key roles in skeletal development and maintenance of bone mass.. Dr. Williams joined VARI as a Scientific Investigator in July 1999. He became a Professor in 2006 and was named Director of the Center for Cancer and Cell Biology in 2010. Dr. Williams was a postdoctoral ...
We move on to Skeletal Disorders and Diseases in dogs in our SlimDoggy Health Check Series. Wikipedia provides a long list of potential issues, we will take a look at the most common. Osteoarthritis:Just as in humans, arthritis is a degenerative disease caused by the deterioration of the cartilage surrounding our
Vanishing bone disease (Gorham-Stout syndrome) is a rare entity of unknown etiology, characterized by destruction of osseous matrix and proliferation of vascular structures, resulting in destruction and absorption of bone. Despite the extensive investigation of the pathogenetic mechanisms of the disease, its etiology hasnt been clarified and several theories exist. The syndrome can affect one or multiple bones of the patient, including the skull, the upper and lower extremities, the spine and pelvis. The clinical presentation of a patient suffering from vanishing bone disease includes, pain, functional impairment and swelling of the affected region, although asymptomatic cases have been reported, as well as cases in which the diagnosis was made after a pathologic fracture ...
A bone with osteoporosis Scientists hope their findings could help to treat common forms of osteoporosis. This photo is taken from BBC.
The third edition of Dr. Greenfields book suffers in scope and completeness when compared to two other recent multivolume texts on the same subject. Newer modalities, including nuclear imaging, computed tomography, and angiography, are only briefly discussed. The organization of the text is based on roentgen characteristics and is excellent as are the bibliography and indexing. The quality of many of the illustrations is poor and in some the important information is barely visible. ...
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Looking for online definition of hypophosphatemic bone disease in the Medical Dictionary? hypophosphatemic bone disease explanation free. What is hypophosphatemic bone disease? Meaning of hypophosphatemic bone disease medical term. What does hypophosphatemic bone disease mean?
consists of a mixture of osteomalacia, hyperparathyroid bone disease, osteoporosis and osteosclerosis. Osteomalacia results from failure of the kidney to convert cholecalciferol to its active metabolite 1,25 dihydroxycholecalciferol. A deficiency of the later leads to diminished intestinal absorption of calcium, hypocalcemia and reduction in the calcification of osteiod. Osteitis fibrosa results from secondary hyperparathyroidism, the parathyroid glands being stimulated by the low plasma calcium and possibly also by hyperphosphataemia. In some patients tertiary or autonomous hyperparathyroidism develops. Osteoporosis occurs in many patients possibly related to mild malnutrition. Osteosclerosis is seen mainly in the sacral area; at the base of the skull and in the vertebrae; the cause of this unusual reaction is not known ...
TY - JOUR. T1 - International Myeloma Working Group recommendations for the treatment of multiple myeloma-related bone disease.. AU - Terpos, Evangelos. AU - Morgan, Gareth. AU - Dimopoulos, Meletios A.. AU - Drake, Matthew M. AU - Lentzsch, Suzanne. AU - Raje, Noopur. AU - Sezer, Orhan. AU - García-Sanz, Ramón. AU - Shimizu, Kazuyuki. AU - Turesson, Ingemar. AU - Reiman, Tony. AU - Jurczyszyn, Artur. AU - Merlini, Giampaolo. AU - Spencer, Andrew. AU - Leleu, Xavier. AU - Cavo, Michele. AU - Munshi, Nikhil. AU - Rajkumar, S Vincent. AU - Durie, Brian G M. AU - Roodman, G. David. PY - 2013/6/20. Y1 - 2013/6/20. N2 - The aim of the International Myeloma Working Group was to develop practice recommendations for the management of multiple myeloma (MM) -related bone disease. An interdisciplinary panel of clinical experts on MM and myeloma bone disease developed recommendations based on published data through August 2012. Expert consensus was used to propose additional recommendations in situations ...
This clinic treats patients who have metabolic bone diseases - thin bones, thick bones, soft bones, brittle bones and irregular bones. These diseases are caused by problems with mineral metabolism, nutrition, and some genetic diseases. In addition to the above list, we see patients with many kinds of diseases, including:
Tumor-induced bone disease is common among patients with advanced solid cancers, especially those with breast, prostate, and lung malignancies. The tendency of these cancers to metastasize to bone and induce bone destruction is, in part, due to alterations in integrin expression and signaling. Substantial evidence from preclinical studies shows that increased expression of integrin αvβ3 in tumor cells promotes the metastatic and bone-invasive phenotype. Integrin αvβ3 mediates cell adhesion to several extracellular matrix proteins in the bone microenvironment which is necessary for tumor cell colonization as well as the transmission of mechanical signals for tumor progression. This review will discuss the αvβ3 integrin receptor in the context of tumor-induced bone disease. Specifically, the focus will be the role of αvβ3 in modulating cancer metastasis to bone and tumor cell response to the bone microenvironment, including downstream signaling pathways that contribute to tumor-induced osteolysis.
Results Data from the first fifteen babies is presented.. Using an ALP cut-off of 400 IU/L to define osteopenia, babies with increased ALP, tended to have a higher PTH (p = 0.07), with mean PTH,7.9 pmol/L being associated with bone disease. Hypophosphatemia (Phosphate,1.5 mmol/l), a known risk factor, was significantly associated with hyperparathyroidism (p = 0.005). PTH and TmP-GFR were inversely correlated. Plasma calcium remained unchanged and within normal range. ...
Washington D.C. [USA], Nov 14 (ANI): A simple colour-changing test to detect fluoride in drinking water could in the future prevent the crippling bone disease, skeletal fluorosis, in developing countries such as India and Tanzania.
A fast colour-changing test that detects fluoride in drinking water could help prevent the crippling bone disease skeletal fluorosis in developing countries, say UK researchers. Jim Drury has more.}
If your child has a bone tumor or other bone disease, he or she will receive the best care at an academic medical center like NewYork-Presbyterian/Morgan Stanley Childrens Hospital. Our dedicated pediatric orthopedic specialists are known around the world for their expertise in caring for young patients, using treatments based on the latest medical findings.
Massachusetts Institute of Technology (MIT) researchers have for the first time carried out a multi-scale analysis to shed light on how bones material flaws lead to brittle bone disease.
Handmade, old-fashioned dolls crafted by Gardner, Kan., couple Jesse and Pat Wilkerson benefit brittle bone disease research by aiding the Osteogenesis Imperfecta Foundation.
Anna Ugarph from the research group Growth and Metabolism will defend her thesis Bone disease and Diabetes Mellitus on September 22, 2017. Main supervisor is Professor Kerstin Brismar. What is the main focus of your thesis? Bone disease and Diabetes Mellitus.
Metabolic bone diseases are disorders of bone strength, usually caused by abnormalities of minerals (such as calcium or phosphorus), vitamin D, bone mass or
Detailed information on bone cancers, including chondrosarcoma, ewings sarcoma, myeloma bone disease, multiple myeloma, and osteosarcoma
Peter Croucher manages a highly competitive research group with an international reputation for research in bone cell biology, tumour-induced bone disease and its clinical translation. This includes research into the understanding how tumours grow in bone and cause bone disease, particularly the haematological malignancy multiple myeloma, and breast and prostate cancer bone metastasis.
This 2 arm study will compare the efficacy of a regimen of intravenous (iv) and oral Bondronat with that of zoledronic acid in patients with malignant b
Bone disease. People with renal failure develop weaken bones from abnormal mineralization of the bone. Renal osteodystrophy is the name of this process where calcium and phosphorus do not deposit into the bone correctly and therefore the persons bones are prone to fractures ...
If you have even broken a bone, then you know the pain that is involved. Perhaps your break was so bad that you had to have surgery on it to make sure the bone could successfully repair itself. Then, of course, there was the cast that you had to wear afterwards.
If you have even broken a bone, then you know the pain that is involved. Perhaps your break was so bad that you had to have surgery on it to make sure the bone could successfully repair itself. Then, of course, there was the cast that you had to wear afterwards.
Measurements of total body myeloma cell number and osteoclast activating factor (OAF) production by bone marrow myeloma cells in vitro were made in 33 patients with plasma cell myeloma. There was a highly significant correlation (P | 0.001) between t
Experts at the Scientific Advisory Committee on Nutrition (SACN) are urging the UK public to consider taking a daily supplement of vitamin D.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
Bone and Cancer ( Topics in Bone Biology ) by Felix Brooner http://img194.imageshack.us/img194/2782/boneandcancercover.jpg Pages: 273 Publisher: -- Edition: 1st., Vol. 5, 2009 Language: English
While supplementing your diet with Calcium and Vitamin D is proven to bring down risk of osteoporosis, as well as catalyze effective treatment in patients, Osteoporosis is a disease of multiple variables. Excessive smoking and alcohol consumption, for example, can increase your risk of falling prey to this bone disease. Even extended working hours can affect your back and you can get prone to catching this disease.. Try to avoid any inconsistency in your schedule in order to stay away from this serious disorder. Make sure youre sleeping adequately for the day and your sleeping posture isnt doing any harm to you. Sometimes, just the lack of a quality mattress can be such a nuisance that you rise the next day feeling your back and spinal cord absolutely stiff. SleepJunkie.org provides the top mattress articles available today so that you buy the best out of the lot.. If you are susceptible to or have osteoporosis, make sure to consult your medical provider to address all the variables relevant ...
A research group led by Professor Hannes Lohi at the University of Helsinki and Folkhälsan Research Center has uncovered a new skeletal disease in dogs. The disease was recognized in the Karelian Bear Dog breed and associated with an autosomal recessive defect in the alkaline phosphatase gene, ALPL.
Dwarfism is a condition which can affect people congenitally or take place due to certain dysfunctions in the organism such as hormone imbalances, organ dysfunction, bone diseases etc.
Patients on kidney dialysis and long-term intravenous feeding frequently suffer a painful bone disease apparently caused by aluminum in solutions used in treatment, researchers have found.Dr. Gordon
I JUST STARTED GOING TO A PAIN MANAGEMENT SPECIALIST AS I HAVE A BONE DISEASE THAT CAUSES ME A LOT OF PAIN, HAS SINCE CHILD HOOD. I WAS SEEING A GP THAT GOT ME COMPLETELY RIPPED ON NORCO 10S OVER A...
A 47-year-old Michigan woman developed a bone disease rarely seen in the U.S. after she drank a pitcher of tea made from at least 100 tea bags daily, for 17...
http://stat.ks.kidsklik.com/statics/files/2012/07/1341147562465791179.jpg Selokambang swimming pool is about 6km from west of Lumajang. The visitors can enjoy the beautiful, fresh and natural panorama. The society around it believe that the water can be recovered kinds of diseases, for example skin disease, rheumatic, bone disease, etc. The facilities are swimming pool special for adult, children, fishing area and graceful swans. Visit Selokambang swimming pool with your family and enjoy
BeWellBuzz) Food is the key ingredient for a human being to survive, but survival isnt everything unless you combine it with healthy survival. To stay fit and healthy, we need to consume foods that are rich in nutrients that are good for our body and mind. Why Do We Need Bone-Building Foods? Bone building is a lifelong process, and if you take action now, you can ... Continue Reading ...
Glycosphingolipids (GSLs) are essential constituents of cell membranes and lipid rafts and can modulate signal transduction events. The contribution of GSLs in osteoclast (OC) activation and osteolytic bone diseases in malignancies such as the plasma cell dyscrasia multiple myeloma (MM) is not known. Here, we tested the hypothesis that pathological activation of OCs in MM requires de novo GSL synthesis and is further enhanced by myeloma cell-derived GSLs. Glucosylceramide synthase (GCS) inhibitors, including the clinically approved agent N-butyl-deoxynojirimycin (NB-DNJ), prevented OC development and activation by disrupting RANKL-induced localization of TRAF6 and c-SRC into lipid rafts and preventing nuclear accumulation of transcriptional activator NFATc1. GM3 was the prevailing GSL produced by patient-derived myeloma cells and MM cell lines, and exogenous addition of GM3 synergistically enhanced the ability of the pro-osteoclastogenic factors RANKL and insulin-like growth factor 1 (IGF-1) to induce
Bisphosphonates are common first line medications used for the management of benign bone disease. One of the most devastating complications associated with bisphosphonate use is osteonecrosis of the jaws which may be related to duration of exposure and hence cumulative dose, dental interventions, medical co-morbidities or in some circumstances with no identifiable aggravating factor. While jaw osteonecrosis is a devastating outcome which is currently difficult to manage, various forms of delayed dental healing may be a less dramatic and, therefore, poorly-recognised complications of bisphosphonate use for the treatment of osteoporosis. It is hypothesised that long-term (more than 1 years duration) bisphosphonate use for the treatment of post-menopausal osteoporosis or other benign bone disease is associated with impaired dental healing. A case-control study has been chosen to test the hypothesis as the outcome event rate is likely to be very low. A total of 54 cases will be recruited into the study
INTRODUCTION: Noninvasive measures of bone activity include intact parathyroid hormone (iPTH) and bone-specific alkaline phosphatase (BSAP). Whether BSAP measurement alone or in combination with other biochemical data provides more reliable information about bone turnover than iPTH alone in African Americans on hemodialysis is unknown. METHODS: This cross-sectional study aimed to determine the optimal predictor and cutoff points for BSAP, iPTH, calcium and phosphorus in classifying bone biopsy findings. Forty-three African American hemodialysis patients were available for analysis. Biochemical data on the day of biopsy across a spectrum of qualitative histologic bone features were compared. Classification and regression tree analysis was used to determine both the optimal predictor and cutoff points for BSAP, iPTH, calcium and phosphorus in identifying bone turnover status. FINDINGS: Seven subjects had adynamic disease, 31 had mild/moderate hyperparathyroid bone features, and five had severe
Get more information about osteoporosis, osteoporosis bone disease, bone density testing, bone scanning test, osteoporosis bone density test at Enlist Health Guide.
Also called disappearing bone disease. Extensive loss of calcium from a single bone so that it cannot be seen on x-ray. Any bone can be involved but the upper arm, shoulder, and jaw are most frequent. This type of selective decalcification is sometimes associated with the presence of an hemangioma, a knot of distended blood vessels. The synonyms for this condition include invisible bone disease, vanishing bone disease, phantom bone disease and massive osteolysis.
ABSTRACT. The term metabolic bone disease encompasses an unrelated group of systemic conditions that impact on skeletal collagen and mineral metabolism. Their asymptomatic progression leads to advanced skeletal debilitation and late clinical manifestation. This article provides a brief overview of advances in the understanding of the pathogenesis of rickets, osteomalacia and age-related osteoporosis.. ...
Mild cases can be treated by proper diet. Dusting salad and insects with a high-quality calcium and D3 supplement is the most effective. The best one on the market right now is Rep-Cal Calcium with Vit.D. Make sure the greens you are using are nutritious and not calcium binding (refer to my list of appropriate fruits and vegetables).. Install a new mercury vapor UVB bulb. Whenever possible, expose your bearded dragon to unfiltered natural sunlight under supervision.. Severe MBD results in rubbery bones and eventually, death. If you suspect that your dragon has MBD, get him/her to the vet as soon as possible.. ...
2000-5000 IU/kg) 2. Prolapsed Organs 3. Metabolic Bone Disease Turtles fed primarily organ meats (liver, heart) or pure muscle (beef, pork, chicken) will develop metabolic bone disease and other nutritional problems. Rx. Vit D3 parenteral and diet correction with suppliments. 4. Shell Rot Usually secondary to the turtle spending all of its time in the water or water which is of poor quality Infectious Diseases 1. Bacterial Disease Debilitated chelonians are vulnerable to respiratory diseases caused by bacteria. Aquatic turtles with lung disease will frequently float in the water asymmetrically or have difficulty surfacing or submerging Septic cutaneous ulcerative disease (SCUD) is a problem most frequently observed in feshwater aquatic turtles like sliders and cooters. The causative agent is Citrobacter fruendii, a Gram-negative rod. Affected animals may present with deep skin ulcers in a variety of locations. Turtles are prone to both superficial and deep mycoses. There are several reports in ...
Dkk1 plays a key role in the osteoblast suppression of myeloma bone disease, but the majority of studies to date have focused upon the role of myeloma-derived Dkk1 (13, 15). Stromal cells and osteoblasts are known sources of Dkk1 (16, 17), and this study provides compelling evidence for a key role of stromal-derived Dkk1 to promote myeloma development. There is increasing evidence to suggest that cells of the bone marrow microenvironment are altered in MGUS, and that Dkk1 is increased in patients with MGUS, associated with a loss of trabecular bone (5-7). In support of this, our studies show increased host-derived Dkk1 in myeloma-permissive KaLwRij mice that is associated with a significant reduction in trabecular bone volume. Furthermore, we have discovered a novel role of BMSCs to promote myeloma establishment and progression in an otherwise nonpermissive environment. This is mediated, in part, through stromal-derived Dkk1, however the inability of overexpression of Dkk1 in normal BMSCs to ...
of soft tissue and bone tumors. The United States and Canadian Academy of Pathology is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.. The United States and Canadian Academy of Pathology designates this live activity for a maximum of 16 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. The USCAP is approved by the American Board of Pathology (ABP) to offer Self-Assessment credits (SAMs) for the purpose of meeting the ABP requirements for Maintenance of Certification (MOC). Registrants must take and pass the post-test in order to claim SAMs credit. Physicians can earn a maximum of 12 SAM credit hours.. ...
Risks for Osteoporosis In young women In others Low calcium intake Low body weight Limited exercise Hypoestrogenism Menopausal/postmenopausal status-without HRT Cigarette smoking Low-trauma fractures Hyperparathyroidism Chronic corticosteroid use
Steaming bone disorder Addisons disease, Adrenal insufficiency, Adrenal failure, Adrenal cortical insufficiencyCentral retinitis, Degeneration of the retina, Retina degeneration, Hearing loss, Hypoacusis, , steaming bone disorder
BETHESDA, Md--Patients with malignant bone disease are benefiting from more widespread use of currently available bisphosphonates, and a new generation of bisphosphonate compounds under investigation appears to have higher potency, allowing for smaller doses, researchers said at an NIH symposium on the skeletal complications of malignancy. 1
A bone scan is a nuclear imaging test that helps diagnose and track several types of bone disease. Your doctor may order a bone scan if you have unexplained skeletal pain suggesting bone loss, bone infection or a bone injury undetectable on a standard X-ray.
October 20 is World Osteoporosis Day. Osteoporosis occurs when there is loss in peak bone mass and loss of calcium, leading to hip, knee and shoulder fractures.
Diagnosis Code H05.329 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
In a workshop convened to assess evidence for the potential benefits of phytoestrogen-containing foods or supplements on diseases or conditions affecting older populations with preclinical, clinical, and epidemiologic data on the cardiovascular system, various cancers, bone diseases, and menopausal symptoms were the focus of the discussions, posted in PubMed, showed that based on the information presented, isoflavone-containing soy foods may have favorable effects on the cardiovascular system, but major knowledge gaps still exist regarding effects ofphytoestrogen supplements on bone diseases, various cancers, menopausal symptoms, and cognitive function ...
But throughout her life, Jones hasnt let the disease stop her from doing the things she wanted to do. As a child, she loved dancing and kept doing it despite injuries and her mothers objections.. Shes turned that drive into a career and is now the executive director of the XLH Network, a patient advocacy group.. For the past year, Jones and her children have been taking a newly available medication called burosumab (Crysvita) that helps the body retain phosphorus. She said it has eased her muscle pain and fatigue.. "I didnt realize how tired I was until I wasnt anymore," she said. "I really had no idea how exhausted I was.". Her kids are only 6 and 8 right now, so Jones is hoping the drug will help prevent some of the damage associated with the disease.. XLH is caused by a mutation in an X chromosome. Men have an X and a Y chromosome, so if they have XLH, they will always pass it on to their offspring. Because women have two X chromosomes, a woman with XLH has a 50-50 chance of passing the ...
The 1940s to the 1950s marked the start of the Endocrine Division, the Endocrine Clinic, the publication of Diseases of the Endocrine Glands, the earliest use of ACTH therapeutically.
Since weve been covering vitamin D lately, I thought wed discuss some of the metabolic bone diseases caused by D deficiency in children and adults, like osteomalacia, aka rickets in children. Accord
wikiHow has Bone Health how to articles with step-by-step instructions and photos. How to instructions on topics such as Bone Fractures, Osteoporosis, Bone Diseases and more.
A turtle shell is made of two parts: the plastron and carapace. Both are covered with scutes. Retained scutes (dysecdysis), metabolic bone disease, and trauma are common diseases of the shell.
This volume highlights new insights into the mechanisms of bone development, including cellular and mechanical factors, receptors, and signaling pathways and their role in both normative and pathologic states of bone.. The second of two volumes, this volume comprises three sections: (1) new insights on the interaction of blood vessels and bone, particularly the role of angiogenic signals and hypoxia in osteogenesis and bone repair, as well as the dysregulation of transcription factors causing arterial calcification; (2) a new theme-integrating the evolving role of immune cells, infection, and inflammation in causing bone loss seen, for example, in various forms of arthritides; and (3) the clinical and therapeutic challenges in bone, stone, and joint diseases, and areas such as identification of high-risk patients, advent of novel therapeutic targets, genetic aberrations causing bone disease, and issues surrounding bone loss in malignancy, hyperparathyroidism, and adrenal disorders.. NOTE: Annals ...
Since his article, the PTH assay has continued to be challenging. Serum biomarkers have always been unreliable as markers of bone pathology in renal disease (2, 3). Most doctors realize that PTH levels are neither accurate nor precise. PTH is cleaved to an 84 amino acid peptide within the parathyroid gland and stored in secretory granules until released. Non intact fragments are also secreted from the gland. Once released, PTH has a half life is only 2 to 4 minutes, and it is quickly fragmented further then metabolized. Bioassays cross react with these fragments, which may or may not have bioactivity. The NKF KDOQI Guidelines relied on the Nichols Allegro intact PTH assay and the range of 150 to 300 pg/m was best correlated with normal turnover. The allegro assay used an immunoreactive "sandwich" with two antibodies each directed against a different portion of the peptide. This assay did not specifically target the active N terminal. A third generation bio intact assay used an antibody which ...
Question: My dog is 11 and a half lab has been always healthy and her blood test back in September was just perfect. On November 5th, she started limping and when I took her to the vet, the xray showed that she has a lytic bone lesion in her right shoulder. Her lungs were clear. …
Osteopetrosis, also known as marble bone disease or Albers-Schonberg disease, is an extremely rare inherited disorder in which the bones harden and become denser but are still more brittle than normal bones.
Stephen has brittle bone disease which means his independence is greatly reduced as, to prevent injury, he has to rely on his parents helping him with day to day tasks. Stephens Occupational Therapist originally contacted DEMAND because he was at risk of injury from the rigid arms of his dining chair when getting in and out. To stop this from happening, we modified the chairs arms so that they could rotate up and out of the way, allowing Stephen to get in and out of the chair by himself. To improve his independence even further we incorporated a neat, easy to operate mechanism which allowed Stephen to move his chair closer to, and away from, the table without assistance.. Before DEMAND helped, getting Stephen close enough to the dining table on his high chair was really hard. We had to try and push him forward towards the dining table, as thats the only way we could manage. There was always the risk of tipping him over. Now Stephen is able to pull himself into the table.". ...
Learn more | Buy now | FORMULA DEER PLACENTA - 100 mgStimulates the renewal process of ageing, retains the strength and vitality of the organ, and reverses the ageing process. It helps improve condition for patients with health condition such as diabetes, Alzheimers disease, bone diseases, menopause, impotence, chronic fatigue etc.Good bio-compatibility…
A team of researchers led by MCB Professor and HHMI Investigator Michael Rape has found that in addition to its importance for bone strength, calcium has a major role as a signal molecule that regulates bone formation and growth at a cellular level. This finding could help locate and correct erroneous signals during bone growth that lead to bone abnormalities.. MCB Associate Professor Diana Bautista and MCB Professor and HHMI Investigator Randy Schekman co-authored this study. ...
A team of researchers led by MCB Professor and HHMI Investigator Michael Rape has found that in addition to its importance for bone strength, calcium has a major role as a signal molecule that regulates bone formation and growth at a cellular level. This finding could help locate and correct erroneous signals during bone growth that lead to bone abnormalities.. MCB Associate Professor Diana Bautista and MCB Professor and HHMI Investigator Randy Schekman co-authored this study. ...
Womens bone health is important- so we take a proactive approach. Learn more about how we test for and maintain bone health- call (574) 364-4000
When the U.S. Environmental Protection Agency (EPA) established the maximum "safe" level of fluoride for U.S. water supplies at 4 ppm, it stated that "skeletal fluorosis has not been described in populations whose water supplies contained less than 4 mg/L fluoride." (EPA Criteria Doc, 1985, p. 48) Although the EPA recognized that skeletal fluorosis was a widespread public health in some areas of India and other developing countries, it implied that skeletal fluorosis only occurred in these areas when the fluoride level in water exceeded 10 ppm. According to EPA:. "EPA notes that crippling skeletal fluorosis, rheumatic attack, pain and stiffness have been observed in a large number of individuals in other countries chronically exposed to fluoride in drinking water at levels of 10 mg/L to 40 mg/L." (EPA, Federal Register, Nov. 14, 1985, p. 47144).. In sharp contrast to EPAs assertions, scientists in India and China have repeatedly found that skeletal fluorosis occurs in populations drinking water ...
The navicular bone /nəˈvɪkjʊlər/ is a small bone found in the feet of most mammals. The navicular bone in humans is one of the tarsal bones, found in the foot. Its name derives from the human bones resemblance to a small boat, caused by the strongly concave proximal articular surface. The term navicular bone or hand navicular bone was formerly used for the scaphoid bone, one of the carpal bones of the wrist. The navicular bone in humans is located on the medial side of the foot, and articulates proximally with the talus, distally with the three cuneiform bones, and laterally with the cuboid. It is the last of the foot bones to start ossification and does not tend to do so until the end of the third year in girls and the beginning of the fourth year in boys, although a large range of variation has been reported. The tibialis posterior is the only muscle that attaches to the navicular bone. The main portion of the muscle inserts into the tuberosity of the navicular bone. An accessory ...
Included below are recent newspaper articles detailing the impact of skeletal fluorosis in India. Of Indias 32 states, 17 have been identified as "endemic" areas for fluorosis, with an estimated 25 million people impacted, and another 66 million "at risk.". In India, the most common cause of fluorosis in India is high-fluoride well water derived from borewells dug deep into the earth. According to field surveys, skeletal fluorosis in India occurs when the fluoride concentration in water exceeds 1 part per million (ppm), and has been found to occur in some communities with only 0.7 parts per million. To put this in perspective, water is purposefully fluoridated in the United States and other fluoridating countries at 0.7 to 1.2 ppm.. While the elevated consumption of water in warm climates such as India along with the increased incidence of malnutrition make direct comparisons of the Indian experience to the "West" difficult, it is striking to observe how narrow the margin is between the doses ...
TY - JOUR. T1 - The use of zoledronic acid in patients with bone metastases from prostate carcinoma: effect on analgesic response and bone metabolism biomarkers. AU - Casuccio, Alessandra. AU - Badalamenti, Giuseppe. AU - Fulfaro, Fabio. AU - Leto, Gaetano. AU - Cicero, Giuseppe. AU - Russo, Antonio. AU - Di Fede, Gaetana. AU - Rini, Giovam Battista. AU - Gebbia, Nicolo. AU - Gebbia, Nicola. AU - Arcara, Carmelo Carlo. AU - Intrivici, Chiara. PY - 2005. Y1 - 2005. N2 - Zoledronic acid is a bisphosphonate that is effective in the treatment of complications of metastatic bone disease. We have carried out a perspective study on 24 consecutive patients with prostate cancer metastatic to bone to verify the effect of zoledronic acid on analgesic response and a possible relationship with the levels of bone metabolism biomarkers. Eligibility for this study required prostate cancer patients with metastatic bone disease and pain not controlled by analgesics. Patients were excluded from the study if they ...
Renal osteodystrophy is currently defined as an alteration of bone morphology in patients with chronic kidney disease (CKD). It is one measure of the skeletal component of the systemic disorder of chronic kidney disease-mineral and bone disorder (CKD-MBD). The term "renal osteodystrophy" was coined in 1943, 60 years after an association was identified between bone disease and renal failure. The traditional types of renal osteodystrophy have been defined on the basis of turnover and mineralization as follows: mild, slight increase in turnover and normal mineralization; osteitis fibrosa, increased turnover and normal mineralization; osteomalacia, decreased turnover and abnormal mineralization; adynamic, decreased turnover and acellularity; mixed, increased turnover with abnormal mineralization. A Kidney Disease: Improving Global Outcomes report has suggested that bone biopsies in patients with CKD should be characterized by determining bone turnover, mineralization, and volume (TMV system). On the ...
Osteopathy was founded by Andrew Taylor Still in 1874. Mr. Still was a physician and a surgeon in the United States in the city of Kirksville, Missouri. The first school of osteopathy was founded in this city in May 1892 .. Knowing a great success with the public, the osteopathy discipline was recognized in 1898 as a profession by the state of Vermont. It was under the presidency of Theodore Roosevelt that entered the list of recognized professions in the United States of America. Roosevelt had himself been successfully treated with osteopathy.. Subsequently, the American osteopathic profession evolved into a medical and surgical practice forgetting the basics of manual therapy and palpation. Only the American School of Osteopathy kept the traditional way of doing osteopathy.. Osteopathy then took roots in Europe in 1917, more specifically in England. The British government set up in 1993, the Osteopaths Act, placing osteopaths at the same level as doctors and dentists. In France, osteopathy ...

Gorhams DiseaseGorham's Disease

Gorhams disease or vanishing bone disease is a rare, progressive musculoskeletal disorder characterized by resorption of bone ... Vanishing bone disease (Gorhams disease) - a rare occurrence of unknown etiology. Author(s): Sumit Ray, Subhalakshmi ... Gorhams disease is a rare bone disorder that is characterized by bone loss (osteolysis), often associated with swelling or ... Gorhams disease is a rare musculoskeletal disease of unknown etiology characterized by progressive osteolysis and massive bone ...
more infohttp://diseaseinfosearch.org/Vanishing+Bone+Disease/3159

Vitamin D - Wilkinson Health Services / Non-retailVitamin D - Wilkinson Health Services / Non-retail

... those with bone disease caused by aluminum; those with chronic liver disease; or those with bone disease associated with kidney ... Metabolic bone disease is common among people with chronic liver disease, and osteoporosis accounts for the majority of cases. ... The use of substances similar to vitamin D has been found to increase bone density in people with kidney disease. The effect of ... OI is a genetic disease in which bones break easily due to a malfunction in the bodys production of collagen. Proper calcium ...
more infohttp://www.wilkinsonpharmacy.com/ns/DisplayMonograph.asp?storeID=CA16677413FA4D59A0FF53842F6ED4E5&DocID=bottomline-vitamind

What is Gorhams Disease? - Lymphangiomatosis & Gorhams Disease AllianceWhat is Gorham's Disease? - Lymphangiomatosis & Gorham's Disease Alliance

disappearing bone disease, vanishing bone disease, phantom bone disease,. massive osteolysis, disseminated osseous bone disease ... As the disease progresses bone deformity occurs with further loss of bone mass and, in the tubular bones (the long bones of the ... 2 Because of the loss of the affected bone, the condition has been referred to as disappearing bone disease, vanishing bone ... Except in growing bone, the rate of breakdown equals the rate of building, thereby maintaining bone mass. In Gorhams disease ...
more infohttps://www.lgdalliance.org/patient-professional-resources/what-is-gorhams-disease/

Bone Diseases | MedlinePlusBone Diseases | MedlinePlus

Learn about different kinds of bone problems and how genetics can play a role. ... Bone diseases increase your risk for breaking bones. ... Pagets disease of bone makes them weak *Bones can also develop ... Bone diseases can make bones easy to break. Different kinds of bone problems include ... After about age 20, you can lose bone faster than you make bone. To have strong bones when you are young, and to prevent bone ...
more infohttps://medlineplus.gov/bonediseases.html

Bone DiseaseBone Disease

... affects women and men of all ethnicities, although the risk of bone disease is highest among women. Bone disease ... Bone disease is a condition that damages the skeleton and makes bones weak and prone to fractures. Weak bones are not a natural ... Bone disease is costly for society and individuals with the disease. In the United States, care for bone fractures from ... The most common bone disease is osteoporosis, which is characterized by low bone mass and deterioration of bone structure. ...
more infohttps://www.news-medical.net/health/Bone-Disease.aspx

Bone Diseases - Multiple Languages: MedlinePlusBone Diseases - Multiple Languages: MedlinePlus

Health Information on Bone Diseases: MedlinePlus Multiple Languages Collection ... Bone Diseases: MedlinePlus Health Topic - English Enfermedades de los huesos: Tema de salud de MedlinePlus - español (Spanish) ... Bone Scan - 简体中文 (Chinese, Simplified (Mandarin dialect)) Bilingual PDF ... Bone Scan - 繁體中文 (Chinese, Traditional (Cantonese dialect)) Bilingual PDF ...
more infohttps://medlineplus.gov/languages/bonediseases.html

Bone disease | Britannica.comBone disease | Britannica.com

Bone disease, any of the diseases or injuries that affect human bones. Diseases and injuries of bones are major causes of ... Although physical injury, causing fracture, dominates over disease, fracture is but one of several common causes of bone ... Bone disease, any of the diseases or injuries that affect human bones. Diseases and injuries of bones are major causes of ... fracture is but one of several common causes of bone disease, and disease is in fact a common cause of fracture. Bone diseases ...
more infohttps://www.britannica.com/science/bone-disease

Osteogenesis Imperfecta (Brittle Bone Disease)Osteogenesis Imperfecta (Brittle Bone Disease)

... prevents the body from building strong bones. People with OI have bones that might break easily. ... This makes their bones weaker and more brittle than normal bones. It can also lead to bone deformities. (Deformed bones do not ... People with OI might have bones that break easily, which is why the condition is commonly called brittle bone disease. ... Preventing Broken Bones. Preventing bone fractures is key for people with OI. There are a number of ways they can lower their ...
more infohttps://kidshealth.org/en/parents/osteogenesis-imperfecta.html

Bone diseases | healthdirectBone diseases | healthdirect

... including links to renal bone disease and osteogenesis imperfecta. ... Trusted information about bone diseases from leading Australian health organisations, ... Pagets disease of bone - myDr.com.au. Pagets disease of bone is characterised by repeated episodes of increased bone ... Osteoporosis (brittle bone diseases) information video , myVMC. Osteoporosis is a condition of reduced bone density or bone ...
more infohttps://www.healthdirect.gov.au/bone-diseases

Top Bone Diseases | LIVESTRONG.COMTop Bone Diseases | LIVESTRONG.COM

Bone diseases are disorders and conditions that cause abnormal development and/or impairment in normal bone development. This ... Paget Disease of Bone. Paget disease of bone (PDB) is the second most common bone remodeling disease after osteoporosis. PDB ... Your bones undergo remodeling throughout life wherein old bone is removed and replaced by new bone. Bone diseases affect normal ... ":"[top bone disorders,common bone diseases,osteoporosis,Paget disease of bone,osteomyelitis,osteogenesis ...
more infohttps://www.livestrong.com/article/119479-top-ten-bone-diseases/

Bone-Immune Cell Crosstalk: Bone DiseasesBone-Immune Cell Crosstalk: Bone Diseases

... Giorgio Mori,1 Patrizia DAmelio,2 Roberta Faccio,3 and Giacomina Brunetti4 ... Glucocorticoid-induced bone disease," The New England Journal of Medicine, vol. 365, pp. 62-70, 2011. View at Google Scholar ... G. D. Roodman, "Pathogenesis of myeloma bone disease," Leukemia, vol. 23, no. 3, pp. 435-441, 2009. View at Publisher · View at ... A. C. Monteiro, A. C. Leal, T. Gonçalves-Silva et al., "T cells induce pre-metastatic osteolytic disease and help bone ...
more infohttps://www.hindawi.com/journals/jir/2015/108451/ref/

Therapeutic Approaches to Bone Diseases | ScienceTherapeutic Approaches to Bone Diseases | Science

As we age or as a result of disease, this delicate balancing act becomes tipped in favor of osteoclasts so that bone resorption ... The strength and integrity of our bones depends on maintaining a delicate balance between bone resorption by osteoclasts and ... and inflammation of bone associated with rheumatoid arthritis or periodontal disease. Far less attention has been paid to ... of the biology of osteoclasts and osteoblasts is providing opportunities for developing therapeutics to treat diseases of bone ...
more infohttp://science.sciencemag.org/content/289/5484/1508.long

Bone disease - Metabolic bone disease | Britannica.comBone disease - Metabolic bone disease | Britannica.com

Metabolic bone disease: The normal function of bone requires an adequate supply of amino acids (the building blocks for ... Skeletal disease, when it is due to inadequacies in the supply or action of the above essentials, associated with abnormalities ... Also, growth, repair, and remodeling of the bone tissue require a precisely regulated supply of hormones, vitamins, and enzymes ... human disease: Diseases of senescence. …joints are changes involving the bone itself. The bone of elderly persons is known to ...
more infohttps://www.britannica.com/science/bone-disease/Metabolic-bone-disease

Pathogenesis of myeloma bone disease.  - PubMed - NCBIPathogenesis of myeloma bone disease. - PubMed - NCBI

Bone disease in multiple myeloma (MM) is characterized by lytic bone lesions, which can cause severe bone pain, pathologic ... However, the lytic bone disease in MM differs from that in other cancer patients who have lytic bone metastases. Although ... Pathogenesis of myeloma bone disease.. Roodman GD1.. Author information. 1. Veterans Affairs Pittsburgh Healthcare System, ... The basis for this severe imbalance between increased osteoclastic bone resorption and decreased bone formation has been a ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/19039321?dopt=Abstract

Cystic Fibrosis and bone diseaseCystic Fibrosis and bone disease

Spine bone density in CF * Factors causing bone disease * Suggetions for management * Why to avoid bisphosphonates * References ... Bone Disease in patients with cystic fibrosis. These are some illustrations from a talk given to our cystic fibrosis group on ... TREATMENT OF BONE DISEASE in patients with cystic fibrosis Malabsorption Nutritional support Especially calcium Try calcium ... FACTORS THAT COULD LEAD TO BONE DISEASE in patients with cystic fibrosis Malabsorption of vitamin D of calcium (.118 in normals ...
more infohttp://courses.washington.edu/bonephys/cf/CF.html

Natural Remedy to Bone Disease?Natural Remedy to Bone Disease?

Severe Bone Disease Treated by Blocking Bacteria. A surface molecule on bacteria that directs bone cells to die has been ... Gene Discovery Offers Hope of Screening Test for Bone Disease. Three genes linked to the development of Pagets disease, a ... Medical experts may be able to solve the mystery behind a rare bone disease after two ancient skeletons with the genetic bone ... Gene Responsible for Recessive Form of Brittle Bone Disease Discovered. Researchers at the National Institutes of Health and ...
more infohttps://www.medindia.net/news/Natural-Remedy-to-Bone-Disease-80317-1.htm

Osteoporosis (Bone Disease) Risk ChartOsteoporosis (Bone Disease) Risk Chart

Risk Chart predicts your risk of developing osteoporosis that leads to brittle bones and fracture. Diet rich in calcium and ... Osteoporosis is a bone disease that leads to an increased risk of fractures. The bone mass is reduced and the bones are porous ... However, the bones of the hip, wrists and spine are most affected. Learn more about the debilitating disease of Osteoporosis by ... Foods that Negatively Affect Bone Density. Calcium and vitamin D are known to improve bone health. Most people are aware of the ...
more infohttps://www.medindia.net/patients/calculators/osteoporosis-risk-chart.asp

Bone disease Archives - Vanguard News NigeriaBone disease Archives - Vanguard News Nigeria

Tag: Bone disease. Bone disease sufferers get free treatment in Delta. On June 21, 2018. 10:11 pmIn News by Emmanuel Okogba ... No fewer than 137 patients suffering from various of orthopaedic diseases in Sapele, Eku, Orere-Okpe, Ughelli and environs, ...
more infohttps://www.vanguardngr.com/tag/bone-disease/

Renal Bone DiseaseRenal Bone Disease

SGH renal department provide a dedicated renal bone specialist in managing patients with wide range of bone disease related to ... bone disease related to high parathyroid hormone,. *Osteoporosis in general population as well as patients with chronic kidney ... Our area of interest including management of hyperparathyroid bone disease, vascular calcification as well as post- transplant ... chronic kidney disease. The spectrums of disease we manage include * ...
more infohttps://www.sgh.com.sg/patient-care/specialties-services/renal-bone-disease

Pathophysiology of Bone Disease in Multiple Myeloma | SpringerLinkPathophysiology of Bone Disease in Multiple Myeloma | SpringerLink

Antisense inhibition of macrophage inflammatory protein 1-alpha blks bone destruction in a model of MM bone disease J Clin ... Multiple Myeloma Bone Marrow Stromal Cell Bone Destruction Adenomatous Polyposis Coli Gene Bone Marrow Plasma These keywords ... bone disease has been omitted from recent staging schema.4 Nonetheless, bone destruction remains a major source of morbidity.5 ... Mechanisms of disease: mechanisms of bone metastasis. N Engl J Med 2004; 350:1655-1664.PubMedCrossRefGoogle Scholar ...
more infohttps://link.springer.com/chapter/10.1007%2F978-1-59745-564-0_27

Epigenetics of Multiple Myeloma Bone Disease | SpringerLinkEpigenetics of Multiple Myeloma Bone Disease | SpringerLink

... is a devastating clinical manifestation of multiple myeloma associated with excessive bone osteolysis, which results from ... Purpose of Review Multiple myeloma bone disease (MMDB) ... Osteoblast suppression in multiple myeloma bone disease. J Bone ... Multiple myeloma bone disease Epigenetics Chromatin regulation Histone modifiers Non-coding RNA Bone marrow mesenchymal stromal ... Multiple myeloma bone disease (MMDB) is a devastating clinical manifestation of multiple myeloma associated with excessive bone ...
more infohttps://link.springer.com/article/10.1007%2Fs40610-019-0117-2

Biomarkers in bone disease (eBook, 2016) [WorldCat.org]Biomarkers in bone disease (eBook, 2016) [WorldCat.org]

Biomarkers in bone disease. [Victor R Preedy;] -- In the past decade there has been a major sea change in the way disease is ... activity and disease severity to determine secular changes in bone disease as applied to Paget\s disease of the bone -- Bone ... activity and disease severity to determine secular changes in bone disease as applied to Pagets disease of the bone --. Bone ... Circulating Sclerostin in Bone Sclerosing Disorders --. Pentraxin 3 as a bone biomarker --. Sirtuins as markers of bone disease ...
more infohttps://www.worldcat.org/title/biomarkers-in-bone-disease/oclc/1110884689

BBC News | HEALTH | Teenagers suffering from brittle bone diseaseBBC News | HEALTH | Teenagers suffering from brittle bone disease

Nutritional experts have released guidelines on how to improve bone health in a bid to reverse the rapid increase in cases of ... Teenage girls with a history of eating disorders have developed the bone-wasting disease osteoporosis, according to the ... The most important time to ensure calcium and vitamin D levels are adequate is while the bones are being formed. The NOS has ... Osteoporosis, which leads to bone fractures, is caused by lack of calcium, regular exercise and vitamin D. Experts predict the ...
more infohttp://news.bbc.co.uk/2/hi/health/221100.stm

Metabolic Bone Disease FellowshipMetabolic Bone Disease Fellowship

Each fellow will cover the monthly Metabolic Bone Disease Clinic, the weekly Metabolic Bone Disease Conference and the weekly ... The Metabolic Bone Disease Fellowship program within the combined orthopaedic, medical and radiology bone consortium represents ... The HSS Metabolic Bone Disease Fellowship is designed to provide the participant with an ongoing, in-depth experience in the ... The Metabolic Bone Disease Fellows are the primary surgeons on service cases under the supervision of the attending staff and ...
more infohttps://www.hss.edu/metabolic-bone-disease-fellowship.asp

Arthritis and bone disease associated with hereditary hemochromatosisArthritis and bone disease associated with hereditary hemochromatosis

... Author. John S Axford, DSc, MD, FRCP, FRCPCH. John S ... J Bone Joint Surg 1960; 33:436.. *Wardle EN, Patton JT. Bone and joint changes in haemochromatosis. Ann Rheum Dis 1969; 28:15. ... Diseases associated with CPPD deposition disease. Arthritis Rheum 1976; 19 Suppl 3:353. ... J Bone Joint Surg Br 1987; 69:41.. *Hamilton EB, Bomford AB, Laws JW, Williams R. The natural history of arthritis in ...
more infohttps://www.uptodate.com/contents/arthritis-and-bone-disease-associated-with-hereditary-hemochromatosis
  • Collagen is an important building block of bones. (kidshealth.org)
  • They either don't have enough collagen in their bones or have collagen that doesn't work as it should. (kidshealth.org)
  • The researchers also showed that Largazole mixed with collagen and calcium phosphate, bone components, helped heal fractured bones in laboratory mice and rabbits. (medindia.net)
  • This approach to the study of disease, referred to as "materiomics" by the lead researcher on the project, Professor Markus Buehler of MIT's Department of Civil and Environmental Engineering, could prove valuable in the study of other diseases "" particularly collagen- and other protein-based diseases "" where a material's behavior and breakdown play a critical role. (redorbit.com)
  • He sees the application of this approach to collagen-based diseases as a starting point that could lead to a similar analysis of the mechanical properties of tissue involved in other protein-based diseases. (redorbit.com)
  • Brittle bone disease affects about one in 16,000 people worldwide, and defective collagen is implicated in many other medical conditions, including Alport syndrome (kidney disease) and Ehlers-Danlos syndrome (overly-flexible skin and joints). (redorbit.com)
  • Dr Lee added: "We now have a deeper understanding for how genetic mutations that affect collagen and collagen processing enzymes cause weak bones. (thedailystar.net)
  • Bone diseases affect normal growth, development or remodeling leading to weakness and/or deformity. (livestrong.com)
  • Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates," Journal of Clinical Oncology , vol. 27, no. 10, pp. 1564-1571, 2009. (hindawi.com)
  • However, the lytic bone disease in MM differs from that in other cancer patients who have lytic bone metastases. (nih.gov)
  • Children born with this type usually will be shorter than their peers, and may have severe bone deformities, breathing problems (which can be life-threatening), brittle teeth, a curved spine, ribcage deformities, and other problems. (kidshealth.org)
  • Navigating the bone marrow niche: translational insights and cancer-driven dysfunction. (springer.com)
  • Mesenchymal stem cells gene signature in high-risk myeloma bone marrow linked to suppression of distinct IGFBP2-expressing small adipocytes. (springer.com)
  • He added: "Other treatments that have worked really well in mice with brittle bones, like bone marrow transplantation, haven't worked as well in humans and are not standard practice as of now. (thedailystar.net)
  • In osteoarthritis , because the weight distribution across the knee or hip joints is uneven, the bone beneath the cartilage thickens on the compression side of the joint and atrophies on the extension side. (britannica.com)
  • Osteochondrodysplasia is a general term for a disorder of the development of bone and cartilage. (wikipedia.org)
  • B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease," The American Journal of Pathology , vol. 169, no. 3, pp. 987-998, 2006. (hindawi.com)
  • PDB affects approximately 1 to 2 percent of white adults aged 55 or older, according to an April 2009 review article published in " Therapeutic Advances in Musculoskeletal Disease . (livestrong.com)
  • For orthopaedists, emphasis is placed on operative and non-operative management of all problems of musculoskeletal disorders, including diseases of the lumbar spine, trauma, orthopaedic oncology, and degenerative diseases. (hss.edu)
  • Bone disease is a condition that damages the skeleton and makes bones weak and prone to fractures. (news-medical.net)
  • WHY TO AVOID BISPHOSPHONATES in patients with cystic fibrosis Etidronate (Didronel) Pamidronate (Aredia) Alendronate (Fosamax) May cause osteomalacia Patients with C.F. already prone to this May inhibit primary modeling of growing bone Safety in children not established only reported in a few cases should do bone biopsies if done on research basis Half-life in bone is >10 years! (washington.edu)
  • Another reason people with HIV are prone to bone disease is that they are living longer. (thebody.com)
  • Most tumors that arise in the bones are noncancerous. (livestrong.com)
  • Cancerous bone tumors are relatively uncommon with an estimated 3,260 new cases per year, according to a 2017 American Cancer Society report. (livestrong.com)
  • Although increased osteoclastic bone destruction is involved in MM and other tumors involving bone, in contrast to other tumors, once the MM tumor burden exceeds 50% in a local area, osteoblast activity is either suppressed or absent. (nih.gov)
  • Medical experts may be able to solve the mystery behind a rare bone disease after two ancient skeletons with the genetic bone disease were unearthed from a medieval Irish graveyard. (medindia.net)
  • Anomalies of the expression of T-cell receptor variable genes in haemochromatosis: an MHC-class I linked genetic disease of iron overload. (uptodate.com)
  • A surface molecule on bacteria that directs bone cells to die has been identified by scientists who claim that this discovery could assist in developing new treatments for severe bone disease. (medindia.net)
  • Treatment of osteoporosis in children with glucocorticoid-treated diseases," Expert Review of Endocrinology & Metabolism , vol. 9, no. 5, pp. 525-534, 2014. (hindawi.com)
  • Expression of many miRNAs has been found to be upregulated or downregulated in bone cancer cells compared to normal bone cells. (intechopen.com)
  • It also predicts if the person requires a special X-ray test called 'bone densitometry or DEXA scan' to confirm the score index from the results of the chart. (medindia.net)
  • I thought you might be interested in this item at http://www.worldcat.org/oclc/1110884689 Title: Biomarkers in bone disease Author: Victor R Preedy Publisher: Dordrecht : Springer, 2016. (worldcat.org)
  • The shoulder, knee, wrist or ankle bones can also be affected. (livestrong.com)
  • The 28-year-old man's case began in September 2010, when he went to the doctor after experiencing hip pain, difficulty walking, trouble moving his right arm and wrist, and enlargement of the bones in his hands, according to the report. (livescience.com)
  • Bone demineralization in cystic fibrosis: evidence of imbalance between bone formation and degradation. (washington.edu)
  • If these animal results are borne out in humans, we may have very potent and effective treatments for both forms of this disease-injury-induced HO and the congenital form. (emaxhealth.com)
  • L. J. Raggatt and N. C. Partridge, "Cellular and molecular mechanisms of bone remodeling," The Journal of Biological Chemistry , vol. 285, no. 33, pp. 25103-25108. (hindawi.com)
  • Mechanisms of disease: mechanisms of bone metastasis. (springer.com)
  • Bone disease can also result from inactivity, smoking, excessive alcohol and caffeine use and adverse effects of some medications, such as steroids, antiretrovirals (ARV) and thyroid medicine. (thebody.com)
  • The goal is to prevent fractures, treat them properly when they do happen, preserve mobility and independence, and strengthen bones and muscles. (kidshealth.org)
  • A government-commissioned report on nutrition and bone health, published on Tuesday, recommends several ways for the public, health workers and the government to improve bone health. (bbc.co.uk)
  • Far less attention has been paid to promoting bone formation with, for example, growth factors or hormones, an approach that would be a valuable adjunct therapy for patients receiving inhibitors of bone resorption. (sciencemag.org)
  • Symptoms may include localized bone pain, tenderness, redness and swelling as well as possible fever and chills. (livestrong.com)
  • In osteomalacia, bone tenderness and pain accompany the slow development of the spontaneous, often symmetric fractures characteristically present in the osteomalacic pelvis and thighbones. (britannica.com)
  • Once the doctors know more about your condition, they will work closely with you to develop a customized treatment plan to optimize bone mass and in turn, reduce fractures and prevent complications. (tuftsmedicalcenter.org)
  • Our doctors often recommend cutting edge diet and lifestyle changes to effectively treat many bone and related diseases. (tuftsmedicalcenter.org)
  • Throughout your time in our care, the doctors of the Metabolic Bone Diseases Clinic will take the time to get to know you so that they can tailor treatment strategies to your needs and lifestyle. (tuftsmedicalcenter.org)
  • The fluoride levels in the man's drinking water were normal, so the doctors were not sure what might have caused his bone disease. (livescience.com)
  • The doctors involved in the case suspected that their patient's abuse of dust spray may have been at least partly to blame for the rapid bone formation. (livescience.com)
  • New bone is created by special bone cells called osteoblast cells. (thebody.com)
  • As we grow older, the osteoclast cells removes bone quicker than the osteoblast cells can produce it. (thebody.com)
  • With PDB, bone resorption and subsequent new bone formation occur at an accelerated rate. (livestrong.com)
  • it occurs when bone resorption occurs faster than bone formation. (britannica.com)
  • Insufficient protein, caloric, and vitamin intake interferes with bone formation during growth and remodeling, directly because of an inadequate supply for matrix formation and indirectly because of a deficient production of crucial hormones and enzymes. (britannica.com)
  • The disease most commonly affects the head of the thighbone, or femoral head. (livestrong.com)
  • The most common bone cancer is osteosarcoma, which primarily affects children, adolescents and young adults. (livestrong.com)