Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
A noninvasive method for assessing BODY COMPOSITION. It is based on the differential absorption of X-RAYS (or GAMMA RAYS) by different tissues such as bone, fat and other soft tissues. The source of (X-ray or gamma-ray) photon beam is generated either from radioisotopes such as GADOLINIUM 153, IODINE 125, or Americanium 241 which emit GAMMA RAYS in the appropriate range; or from an X-ray tube which produces X-RAYS in the desired range. It is primarily used for quantitating BONE MINERAL CONTENT, especially for the diagnosis of OSTEOPOROSIS, and also in measuring BONE MINERALIZATION.
Bone loss due to osteoclastic activity.
The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.
Breaks in bones.
The outer shorter of the two bones of the FOREARM, lying parallel to the ULNA and partially revolving around it.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
The constricted portion of the thigh bone between the femur head and the trochanters.
The longest and largest bone of the skeleton, it is situated between the hip and the knee.
Diseases of BONES.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Metabolic disorder associated with fractures of the femoral neck, vertebrae, and distal forearm. It occurs commonly in women within 15-20 years after menopause, and is caused by factors associated with menopause including estrogen deficiency.
Tumors or cancer located in bone tissue or specific BONES.
Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
The spinal or vertebral column.
The projecting part on each side of the body, formed by the side of the pelvis and the top portion of the femur.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The grafting of bone from a donor site to a recipient site.
An animal or plant species in danger of extinction. Causes can include human activity, changing climate, or change in predator/prey ratios.
Calcium compounds used as food supplements or in food to supply the body with calcium. Dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.
The bones of the free part of the upper extremity including the HUMERUS; RADIUS; and ULNA.
Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.
The largest of the TARSAL BONES which is situated at the lower and back part of the FOOT, forming the HEEL.
Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.
Number of individuals in a population relative to space.
The measurement of the density of a material by measuring the amount of light or radiation passing through (or absorbed by) the material.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
The process of bone formation. Histogenesis of bone including ossification.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Bones that constitute each half of the pelvic girdle in VERTEBRATES, formed by fusion of the ILIUM; ISCHIUM; and PUBIC BONE.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Synthetic or natural materials for the replacement of bones or bone tissue. They include hard tissue replacement polymers, natural coral, hydroxyapatite, beta-tricalcium phosphate, and various other biomaterials. The bone substitutes as inert materials can be incorporated into surrounding tissue or gradually replaced by original tissue.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The region of the HAND between the WRIST and the FINGERS.
The variety of all native living organisms and their various forms and interrelationships.
A functional system which includes the organisms of a natural community together with their environment. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)
The relationships of groups of organisms as reflected by their genetic makeup.
A potent osteoinductive protein that plays a critical role in the differentiation of osteoprogenitor cells into OSTEOBLASTS.
A nonhormonal medication for the treatment of postmenopausal osteoporosis in women. This drug builds healthy bone, restoring some of the bone loss as a result of osteoporosis.
Decrease, loss, or removal of the mineral constituents of bones. Temporary loss of bone mineral content is especially associated with space flight, weightlessness, and extended immobilization. OSTEOPOROSIS is permanent, includes reduction of total bone mass, and is associated with increased rate of fractures. CALCIFICATION, PHYSIOLOGIC is the process of bone remineralizing. (From Dorland, 27th ed; Stedman, 25th ed; Nicogossian, Space Physiology and Medicine, 2d ed, pp327-33)
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.
X-RAY COMPUTERIZED TOMOGRAPHY with resolution in the micrometer range.
The growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants).
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
The physical state of supporting an applied load. This often refers to the weight-bearing bones or joints that support the body's weight, especially those in the spine, hip, knee, and foot.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Resorption or wasting of the tooth-supporting bone (ALVEOLAR PROCESS) in the MAXILLA or MANDIBLE.
Elements of limited time intervals, contributing to particular results or situations.

Alendronate and risedronate for the treatment of postmenopausal osteoporosis: clinical profiles of the once-weekly and once-daily dosing formulations. (1/1450)

OBJECTIVE: The objective of this review is to present the clinical profiles of the once-weekly and once-daily dosing formulations of alendronate and risedronate, the 2 bisphosphonates currently available in the United States for the prevention and treatment of postmenopausal osteoporosis. DATA SOURCE/STUDY SELECTION: Data were obtained from a MEDLINE literature search of all English language articles published between January 1996 and April 2004 using generic names of the bisphosphonates alendronate and risedronate. Results were refined by incorporating terms such as "osteoporosis," "bone mineral density," "fracture risk," and "adverse events." Randomized, controlled trials of once-daily and once-weekly bisphosphonate therapies were selected. Also selected for review were post hoc analyses and extension studies of the original controlled trials, including more recent data from published abstracts from scientific meetings. DATA EXTRACTION: Relevant portions of articles obtained from the literature search were used to summarize the efficacy and tolerability of the 2 therapies. CONCLUSIONS: In prospective trials, both bisphosphonates were effective in reducing vertebral and hip fractures in women with postmenopausal osteoporosis. In the only prospective trial evaluating hip fracture risk reduction as the primary end point, risedronate was effective at reducing hip fracture vs placebo. Both alendronate and risedronate are available in once-weekly formulations that have efficacy and tolerability profiles similar to the once-daily doses. Clinicians should review all available data for both agents as well as the medical history of the patient to make the most appropriate treatment choice.  (+info)

The effect of intravenous zoledronic acid on glucocorticoid-induced multiple vertebral fractures in juvenile systemic lupus erythematosus. (2/1450)

Glucocorticoids are widely used in the treatment of lupus patients, and adverse effects, which include osteoporosis and associated fractures, are frequent. Treatment of osteoporosis of young patients should be effective and not harmful to bone growth and remodeling. Bisphosphonates are drugs that decrease the incidence of bone fractures, but their use in juvenile patients is still controversial because of their possible side effects on the growing skeleton. However, recently published studies showed that linear growth continued normally after treatment with these drugs, and there was no excessive suppression of bone remodeling or mineralization defects. Zoledronic acid is a new intravenous bisphosphonate that has been approved by the US FDA for use with hypercalcemia of malignancies and might be an effective treatment for postmenopausal osteoporosis. The authors report a case of a young girl with systemic lupus who developed multiple vertebral collapses due to glucocorticoid therapy, and zoledronic acid was used producing significant clinical and densitometric improvement.  (+info)

Management of androgen-independent prostate cancer. (3/1450)

BACKGROUND: Although androgen withdrawal can control prostate cancer for long periods in many patients, controversy exists regarding management when the tumor becomes androgen independent. Several options are now available. METHODS: A review of the pertinent literature of the last 20 years was conducted to provide guidance in defining and managing hormone-refractory prostate cancer. RESULTS: Stage D prostate cancer can be subclassified to correlate tumor biology with disease stage. Secondary hormone manipulations may induce responses in patients after failure of initial androgen suppression, and chemotherapy with docetaxel has prolonged survival in patients with androgen-independent prostate cancer (AIPC). The weight of evidence supports the maintenance of castrate levels of testosterone in metastatic AIPC. Bisphosphonates decrease skeletal complications. CONCLUSIONS: Secondary hormone therapy, chemotherapy, and bisphosphonate therapy may provide benefits for selected patients. Correlation of disease stage with biologic characteristics of the tumor and host facilitates proper choices of interventions. Docetaxel-based chemotherapy regimens should be considered for first-line treatment of patients with progressive metastatic AIPC.  (+info)

Effect of administration of alendronate sodium and retinol on the mechanical properties of the femur in ovariectomized rats. (4/1450)

Alendronate sodium, an aminobisphosphonate with potent antiresorptive activity, is used in the treatment of postmenopausal osteoporosis. Retinol, as a component of multivitamin preparations, is frequently used especially by elderly people. There are no reports on the interaction of alendronate sodium and retinol. The aim of the present study was to investigate the effect of administration of alendronate sodium and retinol on mechanical properties of the femoral bone in bilaterally ovariectomized rats. The experiments were carried out on 3-month-old Wistar rats, divided into 7 groups: I - sham-operated control rats, II - ovariectomized control rats, III - ovariectomy + alendronate sodium 3 mg/kg po, IV - ovariectomy + retinol 700 IU/kg po, V - ovariectomy + retinol 3500 IU/kg po, VI - ovariectomy + alendronate sodium 3 mg/kg po + retinol 700 IU/kg po, VII - ovariectomy + alendronate sodium 3 mg/kg po + retinol 3500 IU/kg po. The drugs were administered to the rats daily by oral gavage for 28 days. Body mass gain, bone mass, bone mineral content and calcium content in the femur and L-4 vertebra and mechanical properties of the whole femur (extrinsic stiffness, ultimate load, breaking load, deformation caused by the ultimate load) and the neck of the femur (load at fracture), were examined. Bilateral ovariectomy induced osteopenic changes in the rat skeletal system. Alendronate sodium (3 mg/kg po) counteracted the development of osteopenia induced by ovariectomy. Retinol at both used doses unfavorably affected the examined bone parameters of ovariectomized rats. Retinol administered with alendronate sodium lessened the preventive action of alendronate on the development of osteopenic changes in the skeletal system of ovariectomized rats.  (+info)

Osteonecrosis of the maxilla in a patient with a history of bisphosphonate therapy. (5/1450)

Bisphosphonates, which inhibit osteoclasts, alleviate many of the devastating consequences of metastatic bone disease. However, bisphosphonates may play a role in the development of osteonecrosis of the jaws. We report our experience in the management of a patient with a history of bisphosphonate therapy who presented with osteonecrosis of the jaws following dental extraction to make others, particularly the broader dental community, aware of this potential complication. We also review the pharmacologic properties of bisphosphonates and their possible role in the pathophysiology of osteonecrosis. Until more is known about the role of bisphosphonates in the development of osteonecrosis of the jaws, we recommend that measures be taken to prevent osteonecrosis in those at risk, including, when feasible, a dental consultation before initiating bisphosphonate therapy.  (+info)

Effect of adminitration of etidronate and retinol on bone mechanical properties in ovariectomized rats. (6/1450)

The experiments were carried out on rats, divided into 7 groups: I-sham-operated control rats, II-ovariectomized (OVX) control rats, II- OVX+etidronate (10 mg/kg po), IV-OVX+retinol (700 IU/kg po), V-OVX+retinol (3,500 IU/kg po), VI-OVX+etidronate (10 mg/kg po)+retinol (700 IU/kg po), VII-OVX+etidronate (10 mg/kg po)+retinol (3 500 IU/kg po). The drugs were administered once a day for 4 weeks. Bone mass, content of mineral substances and calcium were examined in the femur, tibia and L-4 vertebra. In the femur, mechanical properties of the whole bone supported on its epiphyses (the ultimate load, the breaking load and the deformation caused by the applied load) and of the femoral neck (the load causing the fracture) were studied. Bilateral ovariectomy induced unfavorable changes in mechanical properties of rat bones, which were partially prevented by administration of etidronate. Retinol at 3,500 IU/kg po caused intensification of the osteoporotic changes, especially it worsened the mechanical properties of bones. The results of the present study do not indicate the existence of any interaction between retinol and etidronate concerning mechanical properties of bones in OVX rats.  (+info)

A systematic review and economic evaluation of alendronate, etidronate, risedronate, raloxifene and teriparatide for the prevention and treatment of postmenopausal osteoporosis. (7/1450)

OBJECTIVES: To establish the clinical effectiveness and cost-effectiveness of selective oestrogen receptor modulators, bisphosphonates and parathyroid hormone (subject to licensing) for the prevention and treatment of osteoporosis and the prevention of osteoporotic fractures in postmenopausal women. DATA SOURCES: Electronic databases. REVIEW METHODS: Studies that met the review's entry criteria were eligible for inclusion in the meta-analyses provided that they reported fracture incidence in terms of the number of patients suffering fractures. Meta-analysis was carried out using the random-effects model. A model was constructed to estimate the cost-effectiveness of osteoporosis interventions. The model calculated the number of fractures that occurred and provided the costs associated with osteoporotic fractures, and the quality-adjusted life-years (QALYs). In addition, the conditions of breast cancer and coronary heart disease (CHD) were modelled, as some interventions have been shown to affect the risk of these conditions. RESULTS: Ninety randomised controlled trials (RCTs) met the inclusion criteria. They related to the five interventions (alendronate, etidronate, risedronate, raloxifene and teriparatide) and to five comparators (calcium, calcium plus vitamin D, calcitriol, hormone replacement therapy and exercise), as well as placebo or no treatment. All five interventions have been shown to reduce the risk of vertebral fracture in women with severe osteoporosis with adequate calcium intakes. However, none of these drugs has been demonstrated, by direct comparison, to be significantly more effective than either each other or the other active interventions reviewed in this report. The intervention costs of treating all osteoporotic women, for a period of 5 years, were in the region of pound 900-1500 million for alendronate, etidronate, risedronate and raloxifene. The cost per QALY ratios fell dramatically with age. Assuming the risks of a woman with severe osteoporosis at the threshold of osteoporosis, no treatment had a cost per QALY below pound 35,000 at 50 years of age. At 60 years of age, the cost per QALY of raloxifene was pound 26,000 assuming no impact on hip fractures, and pound 31,000 assuming an adverse effect. However, these results are driven by the effect on breast cancer and the assumptions made regarding this disease state. No other intervention had a cost per QALY below pound 35,000. When analyses were conducted assuming that the fracture risk is doubled at each site, alendronate and risedronate had cost per QALY ratios below pound 30,000 at all ages. For women at the threshold of osteoporosis, without a prior fracture and aged 70 years, the cost per QALY of the three bisphosphonates ranged from pound 34,000 to pound 41,000. Raloxifene had a cost per QALY of pound 23,000, assuming no effect on hip fracture, given assumptions regarding breast cancer. At 80 years of age, the cost per QALY of alendronate and risedronate was below pound 20,000. This was true for etidronate when incorporating observational data, but the value rose to pound 69,000 when only RCT data were used. No other intervention had a cost per QALY below pound 35,000. It was assumed that doubling the risk of fracture for women without a prior fracture would give results similar to patients at the threshold of osteoporosis with a prior fracture. CONCLUSIONS: Of the five interventions, only raloxifene appeared to reduce the risk of vertebral fracture in postmenopausal women unselected for low bone mineral density (BMD). However, as the full data have not been made public, there is some uncertainty regarding this result. None of the five interventions has been shown to reduce the risk of non-vertebral fracture in women unselected for low BMD. All of the proposed interventions provided gains in QALYs compared with no treatment in women with sufficient calcium and vitamin D intakes. The size of the QALY gain for each intervention was strongly related to the age of the patient. The estimated costs varied widely for the interventions. These net costs were markedly different by age, with some interventions becoming cost-saving at higher age ranges in patients with a prior fracture. Areas for future research include: the evidence base for the efficacy of fracture prevention in the very elderly, reanalysis of raloxifene using a dedicated breast cancer and CHD model, and more trials considering the cost-effectiveness of teriparatide.  (+info)

Does alendronate reduce the risk of fracture in men? A meta-analysis incorporating prior knowledge of anti-fracture efficacy in women. (8/1450)

BACKGROUND: Alendronate has been found to reduce the risk of fractures in postmenopausal women as demonstrated in multiple randomized controlled trials enrolling thousands of women. Yet there is a paucity of such randomized controlled trials in osteoporotic men. Our objective was to systematically review the anti-fracture efficacy of alendronate in men with low bone mass or with a history of prevalent fracture(s) and incorporate prior knowledge of alendronate efficacy in women in the analysis. METHODS: We examined randomized controlled trials in men comparing the anti-fracture efficacy of alendronate to placebo or calcium or vitamin D, or any combination of these. Studies of men with secondary causes of osteoporosis other than hypogonadism were excluded. We searched the following electronic databases (without language restrictions) for potentially relevant citations: Medline, Medline in Process (1966-May 24/2004), and Embase (1996-2004). We also contacted the manufacturer of the drug in search of other relevant trials. Two reviewers independently identified two trials (including 375 men), which met all inclusion criteria. Data were abstracted by one reviewer and checked by another. Results of the male trials were pooled using Bayesian random effects models, incorporating prior information of anti-fracture efficacy from meta-analyses of women. RESULTS: The odds ratios of incident fractures in men (with 95% credibility intervals) with alendronate (10 mg daily) were: vertebral fractures, 0.44 (0.23, 0.83) and non-vertebral fractures, 0.60 (0.29, 1.44). CONCLUSION: In conclusion, alendronate decreases the risk of vertebral fractures in men at risk. There is currently insufficient evidence of a statistically significant reduction of non-vertebral fractures, but the paucity of trials in men limit the statistical power to detect such an effect.  (+info)

While a kidney transplant can restore healthy kidney function, recipients remain at increased risk of fractures, heart disease, diabetes and some cancers. The VITALE study shows that, compared with currently recommended doses, high doses of oral vitamin D (cholecalciferol) lower the risk of fractures, but have no effect on the risks of heart disease, diabetes or cancer after a kidney transplant.
New study reveals that oral bisphosphonate osteoporosis drugs including Actonel, Boniva, and Fosamax, could be associated with esophageal cancer.
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A new UK study that followed a large number of people found that those who took 10 or more prescriptions for oral bisphosphonates, a group of drugs commonly used to treat the bone disease, were at higher risk of developing esophageal cancer.
This is a two-site, three-arm, open-label, pilot randomized controlled trial of bone anti-resorptive therapy during ART initiation in HIV-infected adults. Thirty (30) treatment-naïve HIV-infected adults initiating eligible first-line ART regimens will be randomized in a 1:1:1 fashion to one of the following three arms:. ...
A very seldom mentioned effect of bisphosphonates (drugs such as Fosamax, Actonel, and Boniva) is that these drugs block very important metabolic pathways. Even if you never took bisphosphonates, you
Find information on Denosumab (Prolia, Xgeva) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
Persistence rate over 12 months of teriparatide treatment was 34.9% in Japan. Approximately one-third of patients had no subsequent treatment immediately after teriparatide. Monitoring persistence and considering subsequent drugs for osteoporosis are necessary for teriparatide treatment.
Results 33 patients who were started on teriparatide treatment between 2011-2015 were identified (29 female and 4 male). Mean age was 76.2 (range 63-92). All had pre-treatment DXA, and 32 (97%) were compliant with recommendations for initiation of teriparatide treatment with respect to DXA (one patient borderline). All 33 patients had a pre-treatment bone profile within acceptable limits before start of treatment (adjusted Calcium, Serum Parathyroid Hormone, Vitamin D level, e-gfr). 28 (84.8%) patients tried one agent before initiation of Teriparatide treatment and 5 (15.2%) patients tried 2 agents. 24 (72.7%) patients completed the full course of recommended treatment. 11 out of 24 patients who completed Teriparatide treatment have had post-treatment DXA. 3 out of 24 patients who completed Teriparatide treatment had a fragility fracture after treatment. ...
There are no data on the use of denosumab in steroid induced osteoporosis. Postmenopausal women with chronic use of Glucocorticoid (GCs) are at high-risk of osteoporotic fractures. Despite bisphosphonate treatment, a certain proportion of high-risk patients using chronic GCs either do not achieve a satisfactory gain in bone mineral density (BMD) or develop new fragility fractures. Thus, more potent osteoporosis treatment is necessary for this subgroup of patients. This prompts the current study which aims to examine the efficacy of denosumab in current users of oral bisphosphonates for Glucocorticoid-induced Osteoporosis (GIOP ...
The options available for effective osteoporosis treatment continue to grow. Because of the large number of treatment options, many clinicians, particularly in primary care, are uncertain about when to start therapy, which drug to use, and when to stop. The issue of when to stop antifracture therapy is now front and center as evidence accumulates that the antifracture benefits of some treatments persist after discontinuation and as patients increasingly voice concerns about possible rare but serious problems linked to osteoporosis treatment, such as atypical femoral fractures, osteonecrosis of the jaw, arrhythmias, and cancer. The decision about when to stop or change osteoporosis treatment is particularly complex and should be influenced by the expected benefits and harms of continued use and at least some information about what to expect after therapy is stopped (also known as resolution-of-effect). A prolonged skeletal resolution-of-effect, characteristic of at least some bisphosphonates, might be
A prospective, randomized and double blind once-monthly oral Ibandronate and Risedronate in post-menopausal osteoporosis leprosy patients
This page provides useful content and local businesses that can help with your search for Osteoporosis Treatments. You will find helpful, informative articles about Osteoporosis Treatments, including 5 Tips for Preventing Osteoporosis. You will also find local businesses that provide the products or services that you are looking for. Please scroll down to find the local resources in Gainesville, GA that will answer all of your questions about Osteoporosis Treatments.
This page provides useful content and local businesses that can help with your search for Osteoporosis Treatment. You will find helpful, informative articles about Osteoporosis Treatment, including Osteoporosis. You will also find local businesses that provide the products or services that you are looking for. Please scroll down to find the local resources in Buckhannon, WV that will answer all of your questions about Osteoporosis Treatment.
This page provides useful content and local businesses that can help with your search for Osteoporosis Treatment. You will find helpful, informative articles about Osteoporosis Treatment, including Osteoporosis. You will also find local businesses that provide the products or services that you are looking for. Please scroll down to find the local resources in Chaska, MN that will answer all of your questions about Osteoporosis Treatment.
Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Kimm on once a year osteoporosis medication: Hello~ ZOSTAVAX +65yo + MTX ?? ANSWER: YES ABSOLUTELY DEFINITELY YESTERDAY ! THANKS for topic: Once A Year Osteoporosis Medication
Bisphosphonates are common first line medications used for the management of benign bone disease. One of the most devastating complications associated with bisphosphonate use is osteonecrosis of the jaws which may be related to duration of exposure and hence cumulative dose, dental interventions, medical co-morbidities or in some circumstances with no identifiable aggravating factor. While jaw osteonecrosis is a devastating outcome which is currently difficult to manage, various forms of delayed dental healing may be a less dramatic and, therefore, poorly-recognised complications of bisphosphonate use for the treatment of osteoporosis. It is hypothesised that long-term (more than 1 years duration) bisphosphonate use for the treatment of post-menopausal osteoporosis or other benign bone disease is associated with impaired dental healing. A case-control study has been chosen to test the hypothesis as the outcome event rate is likely to be very low. A total of 54 cases will be recruited into the study
Osteoporosis is a disease that affects the bones. As the bones start loosing their usual density they become weaker & are more likely to break. Studies have shown that every one in two women & every one in four men above the age of 50 tend to break bones due to osteoporosis. It can cause serious complications & appropriate measures must be taken to avoid extreme consequences.. There is no exact cure for osteoporosis. The idea of the osteoporosis treatment process is to strengthen the bones in order to protect them. The treatment primarily consists of a combination of drugs and suitable lifestyle changes that help in minimising the rate of bone resorption.. Preventive measures include a modification in the general lifestyle factors, doing more muscle-strengthening exercises and ensuring adequate intake of calcium and vitamin D.The medications used for osteoporosis treatment are anti-resorptive agents. Osteoporosis occurs when the rate of resorption in the bones overtakes the rate of bone ...
Oral daily and weekly bisphosphonates represent the current mainstay of treatment for postmenopausal osteoporosis (PMO). However, the inconvenience of frequent dosing is known to negatively affect adherence to therapy in the long term. This has prompted the development of convenient oral bisphosphonate regimens that feature simple, less frequent dosing schedules. Such regimens require high potency agents, which can be given at low effective doses and that also have good tolerability. Ibandronate is a potent, nitrogen-containing bisphosphonate with proven efficacy when given intermittently to estrogen-depleted beagle dogs, rats and cynomolgus monkeys. Clinically, a pivotal prospective study has established that oral ibandronate has significant vertebral fracture efficacy in PMO, whether given daily (2.5 mg) or intermittently (20 mg every other day for 12 doses every 3 months; extended between-dose interval|2 months). Both oral regimens were well tolerated, which is noteworthy as patients with a history
We did not find any significant correlation between BMD variation and CTX, P1NP, PTH, calcium or 25OHD levels during the study. There was no statistically significant difference between the group with or without clinically significant BMD loss and baseline CTX and P1NP levels, and no difference was observed between CTX or P1NP levels during the follow-up period and prevalence of BMD loss, either.. DISCUSSION. Bisphosphonates increase BMD by slowing bone turno-ver and allowing secondary mineralization to progress, which in turn leads to increased bone mineral content (11). By inhibiting osteoclast action (and therefore bone resorption), bisphosphonates, such as alendronate, act reducing BTM levels and increasing BMD. Although changes in BMD and BTM cannot entirely explain observed fracture risk reduction with alendronate therapy (13,14), these are the most important predictors of fracture risk in clinical practice, and the most easily measurable surrogates for treatment-related efficacy in ...
In QResearch 4.6% of cases and 4.5% of controls had one or more prescriptions for bisphosphonates, as did 4.8% and 4.6%, respectively, in CPRD. About two thirds of patients with a diagnosis of osteoporosis had been prescribed bisphosphonates (64% of cases and 65% of controls in QResearch and 61% and 60%, respectively, in CPRD) and 2% of cases and controls in both databases had prescriptions for bisphosphonates without records of osteoporosis. Bisphosphonate users were more likely to be women and to have a lower BMI. Upper gastrointestinal problems were slightly more common (QResearch: cases 25% in users v 22% in non-users, controls 25% v 20%; CPRD: cases 35% v 29%, controls 33% v 27%) and use of acid lowering drugs was much more common in bisphosphonate users (QResearch: cases 62% in users v 37% in non-users, controls 61% v 32; CPRD: cases 65% v 39%, controls 63% v35%). Among bisphosphonate users, the proportion of patients with rheumatoid arthritis was more than five times higher than in ...
Efficacy and safety of zoledronic acid in the treatment of glucocorticoid-induced osteoporosis Ege Can Serefoglu1, Zafer Tandogdu21Kiziltepe Hospital, Department of Urology, Mardin, Turkey; 2Taksim Teaching Hospital, Department of Urology, Istanbul, TurkeyAbstract: Glucocorticoids are essential in treating many disorders and they are widely used in spite of their negative impact on the skeletal system. As bisphosphonates reduce bone resorption through their action on osteoclasts, they play an important role in management of glucocorticoid-induced osteoporosis. Unlike other bisphosphonates, zoledronic acid is given by intravenous infusion and it has a potential advantage of increasing the compliance and adherence of patients when it is given 5 mg once a year. However, this treatment modality seems to be associated with more adverse events than oral administrations, and further studies with longer follow-up periods must be conducted to determine the safety and cost-effectiveness of long-term treatment
Reclast zoledronic acid - How long is fasting required before reclast (zoledronic acid) is taken? Good news for you! Hi. You DO NOT HAVE TO FAST before, during, or after Reclast (zoledronic acid) being given! Reclast (zoledronic acid) is given intravenously, bypassing the GI tract entirely (unlike the oral bisphosphonates, which require fasting). Bon appetite!
This phase II study will evaluate the efficacy of radiotherapy in combination with zoledronic acid on pain relief and the safety of radiotherapy in bone
Pharmacologic Profile of Risedronate Like all bisphosphonates, risedronate selectively adsorbs to active bone remodeling sites, where it acts to inhibit osteoclast-mediated bone resorption. Risedronate reduces the risk of fracture by preventing bone loss.10 This action results in increased BMD at fracture-prone skeletal sites, notably the lumbar spine and hip, in postmenopausal women with osteopenia11 or osteoporosis.12,13 It has the same effect in patients initiating14 or receiving15 high-dose, longterm ( 6 months) glucocorticoid therapy (prednisone 7.5 mg/d or equivalent). Pharmacokinetic Properties The pharmacokinetic characteristics of risedronate are summarized in Table 3.8,16-19 Risedronate is absorbed rapidly after oral administration and exhibits linear pharmacokinetics over the oral single-dose range of 5 mg to 30 mg.20 The extent of risedronate absorption is comparable when the dose is taken 30 minutes before breakfast or 2 hours after the evening meal, which may permit dosing ...
MAYWOOD, Ill. - Taking time off from certain osteoporosis drugs may be beneficial to bone health, according to a study conducted at Loyola University Health System. Researchers found that bone density remained stable for three years in patients who took a drug holiday from bisphosphonates, a popular class of osteoporosis drugs that can cause fractures in the thigh bones and tissue decay in the jaw bone.. These drugs are potentially harmful when taken for long durations, yet little has been known until now about the length of time osteoporosis patients should go without treatment for this debilitating condition, said Pauline Camacho, MD, study investigator and director of the Loyola University Osteoporosis and Metabolic Bone Disease Center. Our study demonstrated that bones can remain stable for a number of years after these drugs are discontinued.. Doctors recommend that patients take drug holidays from bisphosphonates after four to five years. These drugs continue to stabilize bones and ...
Osteoporosis medication can be a critical way to prevent bone loss and strengthen your bones. Learn more about osteoporosis treatments in this video.
A trend to watch in the postmenopausal osteoporosis drugs market is the emergence of novel agents. There have been encouraging developments in the postmenopausal osteoporosis drug
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Longer intervals between zoledronic acid doses for patients with bone metastases did not result in an increased risk of skeletal-related events (SREs).
Dr. Kremer and co-lead author, Dr. Nancy Mayo, worked with colleagues to evaluate data from more than 21,000 women diagnosed with breast cancer. The relationship between use of oral bisphosphonates and development of bone metastases after diagnosis with breast cancer was evaluated in two groups of women: those with early stage, localized, cancer and those whose cancer had spread to lymph nodes. Their findings showed that women with early stage breast cancer who had taken oral bisphosphonates, either before or after diagnosis of their cancer, had a reduced risk of bone metastasis. In addition, their study showed that women with later stage cancer, who took oral bisphosphonates post-diagnosis, also had a significantly reduced risk of bone metastasis. The researchers also established a dose-response relationship with oral bisphophonate use in women with local disease: longer time spent on bisphophonate medication resulted in a greater reduction of bone metastases. Our study is novel in that it ...
The herbs used in TCM are known for their many therapeutic properties. To investigate their potential in preventing osteoporotic fractures, Taiwanese researchers conducted a nationwide, population-based cohort study. They identified osteoporosis cases and selected a comparison group that was frequency-matched according to sex, age (per five years), diagnosis year of osteoporosis, and index year. They also estimated the difference between the two groups in terms of the development of fracture using the Kaplan-Meier method and the log-rank test.. After the insertion of age, gender, urbanization level, and comorbidities into the Coxs proportional hazard model, the researchers found that the patients who used TCM had a lower hazard ratio of fracture compared to those who did not use TCM. Based on the Kaplan-Meier curves, they also reported that osteoporosis patients who used TCM had a lower incidence of fracture than those who did not. In addition, the researchers observed that patients who used ...
That two word phrase - osteoporosis medications - its so commonplace that most of us dont think much about it. Medications sounds normal, doesnt it? And of course, big pharma
It is a double blind randomized study aiming at estimating the efficiency of oral bisphosphonates on the decrease of osteoporosis by comparing the...
en] Bone Density/drug effects ; Bone Density Conservation Agents/therapeutic use ; Clinical Trials as Topic ; Drug Approval/methods ; Female ; Glucocorticoids/adverse effects ; Humans ; Male ; Osteoporosis/chemically induced/drug therapy/prevention & control ; Research Design ; Sex ...
The Bisphosphonates market is mainly driven by the incidence and prevalence rate of bone diseases. The expansion in geriatric population is the major driver for the bisphosphonates market. Ageing people start losing bone density and may suffer from fractures therefore bisphosphonate treatment becomes necessary for such patients. According to the U.S. Department of Health and Human Services, 2013 survey, nearly 14.1% of the U.S. population was aged above 65 years and is increasing rapidly. Another significant factor favorable for the growth of bisphosphonates market is the escalation in the number of women in the post-menopausal stage, who suffer from the weakening bones. The total number of women attaining menopause is estimated to cross 1 bn. by 2025, according to the International Menopause Society the number of menopausal women is higher in the developing. Incidence rate of cancers like myeloma which cause loss of bone density. Bisphosphonates are also used for therapy in the patients ...
With the launch of the first prescription osteoporosis medication 15 years ago, millions of Americans with the bone-thinning disease began taking the drugs and never looked back.. But now many bone-health doctors are looking back and becoming increasingly uneasy.. In the last few years, evidence has emerged that long-term use of osteoporosis drugs - particularly the oldest class of drugs, the bisphosphonates - may do more harm than good.. ...
03 June 2012 Toronto - New research presented today draws a significant link between the development of osteoporosis, osteoporosis treatment and a reduced risk of breast cancer recurrence.. The study was one of a total of 20 abstracts to be presented by the NCIC Clinical Trials Group (CTG) at the American Society of Clinical Oncology (ASCO) meeting in Chicago. The meeting is considered to be the premier scientific event for oncology professionals. The presentations focus on new ways to treat a variety of cancers including breast, colorectal, lung and prostate.. Todays ASCO presentation is an exploratory study within a completed large clinical trial, which involved more than 7,000 postmenopausal breast cancer patients. The objective of the original trial was to compare the use of two aromatase inhibitors (AIs) - exemestane and anastrozole - as adjuvant therapy to determine which was more effective at preventing recurrence of the disease. Adjuvant therapy is used after initial treatment for ...
03 June 2012 Toronto - New research presented today draws a significant link between the development of osteoporosis, osteoporosis treatment and a reduced risk of breast cancer recurrence.. The study was one of a total of 20 abstracts to be presented by the NCIC Clinical Trials Group (CTG) at the American Society of Clinical Oncology (ASCO) meeting in Chicago. The meeting is considered to be the premier scientific event for oncology professionals. The presentations focus on new ways to treat a variety of cancers including breast, colorectal, lung and prostate.. Todays ASCO presentation is an exploratory study within a completed large clinical trial, which involved more than 7,000 postmenopausal breast cancer patients. The objective of the original trial was to compare the use of two aromatase inhibitors (AIs) - exemestane and anastrozole - as adjuvant therapy to determine which was more effective at preventing recurrence of the disease. Adjuvant therapy is used after initial treatment for ...
For osteoporosis patients unable to exercise, help may be on the way. Thats because scientists have discovered precisely how mechanical stress, such as exercise, promotes new bone growth. This opens the door to entirely new therapies that can trick bones into thinking they are getting a workout.
Although oral bisphosphonates (BPs) are highly effective in preventing fractures, some patients will fracture while on treatment. We identified predictors of such fractures in a population-based cohort of incident users of oral BPs. We screened the Sistema dInformació per al Desenvolupament de lInvestigació en Atenció Primària (SIDIAP) database to identify new users of oral BPs in 2006-2007. SIDIAP includes pharmacy invoice data and primary care electronic medical records for a representative 5 million people in Catalonia (Spain). Exclusion criteria were the following: Paget disease; |40 years of age; and any antiosteoporosis treatment in the previous year. A priori defined risk factors included age, gender, body mass index, vitamin D deficiency, smoking, alcohol drinking, preexisting comorbidities, and medications. Fractures were considered if they appeared at least 6 months after treatment initiation. Fractures while on treatment were defined as those occurring among participants persisting
Zoledronic Acid (ZA) is a potent nitrogen-containing bisphosphonates (NBP) has been extensively used to limit bone turnover in a various diseases including tumors. Recently, clinical trails of Zoledronic Acid demonstrated direct anti-cancer effects as well as the known skeletal-related events. We investigated the effect of 4 NBPs on human tumor cells proliferation and found ZA is most potent for GBM cell, breast cell and GBM patients stem-cell-like cells. ZA also effectively inhibited GBM tumor growth in mouse model. ZA stimulated strong autophagy but not apoptotic signals in all tested cells. One intermediate product of cholesterols synthesis pathway--geranylgeranyl diphosphate (GGPP) rescued cell from the cytotoxicity of ZA. Knock-down RABGGTA, which encoded a subunit of the Rab geranylgeranyltransferase proteins, induced a similar effect as Zoledronic Acid in cancer cell lines. These data suggested great potential for Zoledronic Acid against human cancer.. Note: This abstract was not ...
osteoporosis treatment - Osteoporosis diagnosis usually comes after a fracture or fall, when the weakened bones have caused the damage
Most treatments only slow bone loss. Instead, get the ONLY natural osteoporosis treatment guaranteed to INCREASE bone density. Discover more now!
Zoledronic acid (sometimes called zoledronate) is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures. Reclast and Zometa are two different brands of zoledronic acid. Reclast is used to treat osteoporosis...
Once youve lost bone density, you cant regain it. However, osteoporosis treatment includes lifestyle changes and medications to help slow its progress.
The worldwide osteoporosis drugs market is predicted to witness a notable growth due to the growing occurrence of osteoporosis along with growing old age population during the estimated period. Availability of technically advanced treatment alternatives combined with growing levels of patient awareness, occurrences of chronic ailments and lifestyle related ailments are further predicted to promote the growth and expansion of the global osteoporosis drugs market.. Browse Full Report Visit - http://www.acutemarketreports.com/report/osteoporosis-drug-market-report. Osteoporosis is a chronic ailment that is featured by reduction in bone mass and bone tissues resulting in bone cracks & fractures. It is also considered as a life threatening ailment owing to serious damage and related pain with it. Few of the factors causing osteoporosis are genetic factors, old age, calcium deficiency, vitamin D deficiency, wrong dietary habits, sedentary/inactive lifestyle, and smoking, low body mass, excessive ...
Metabolic Pharmaceuticals has announced a trans-Tasman licensing deal and research collaboration to develop a new osteoporosis treatment.
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Oral regimens for the treatment of osteoporosis, mostly oral bisphosphonates, expose only low efficacy due to their relatively high rate of side-effects and adverse events, with very low persistence rates [2] of about 30% and 9% after 1 and 5 years, respectively [3]. The introduction of intravenous bisphosphonates improved persistence and rendered possible for the first time reliable study outcomes on the efficacy and safety of these drugs, particularly of zoledronic acid, as described in the paper by Black and colleagues [1]. Nevertheless, according to a former study, approximately one-third of patients treated with zoledronic acid suffer from post-infusion symptoms such as pyrexia, influenza-like symptoms, myalgia, headache and arthralgia after the first infusion, and the number of patients with arrhythmia or serious atrial fibrillation is significantly higher in the zoledronic acid group than in the placebo group [4]. Such side-effects and adverse events might be one reason for the small ...
Extracted from text ... SA Pharmaceutical Journal - April 2006 40 DRUG INFO Protos(r) - The first of a new class for osteoporosis: dual action bone agent Approved indication Protos(r) contains strontium ranelate and is indicated for the treatment of postmenopausal osteoporosis to reduce the risk of vertebral and peripheral fractures, including the hip. Mode of action Strontium ranelate has a unique pharmacological profile characterised by an inhibition of bone resorption and a simultaneous stimulation of bone formation. It targets the bone remodelling process by stimulating osteoblast-mediated bone formation and by inhibiting osteoclast-mediated bone resorption. The dual mode of action of strontium ranelate may ..
Results Number of the patients were 53 (male: 4 cases, female: 49 cases), and their characteristics at the beginning of denosumab treatment were as below; age: 64.19±12.0 years old, dose of prednisolon: 10.59±9.97mg/day, BMD of lumber spine: 0.768±0.112g/cm3, T-score of lumber spine: -2.28±1.01, BMD of femoral neck: 0.540±0.085g/cm3, T-score of femoral neck: -2.28±0.76. After 2-years denosumab treatment, T-scores of lumber spine (0.54±0.39 gain) and femoral neck (0.13±0.26 gain) were significantly increased from baseline (Figure; mean ± SEM. *:p,0.05). In addition, the serum markers of bone metabolism, both absorption and formation, were significantly suppressed with denosumab. ...
Bisphosphonates Break Down Bones. A second unrelated study was conducted by the Hospital for Special Surgery in New York City. This team looked at the bone makeup of 21 postmenopausal women who were treated for fractures.. Twelve of the women had been taking osteoporosis drugs for at least three years. The other nine had never taken osteoporosis drugs.. The research team took samples from each patients femur. And analyzed the bones themselves. They used cutting-edge equipment to look at the actual structure of the bone and its properties.. And they discovered big differences between the two groups. They found that the bone tissue was breaking down in the drug group. It was as if the thigh bones were literally crumbling.. When they looked back at the records they found something else significant. All the women in the non-drug group had suffered fracture through injury and accident. But the women in the drug group had suffered the fractures through simple daily living.. Debra Pate is a member of ...
... spermatogenesis-blocking agents MeSH D27.505.696.207 - astringents MeSH D27.505.696.242 - bone density conservation agents MeSH ... bone cements MeSH D27.720.102.187 - cariogenic agents MeSH D27.720.102.223 - cariostatic agents MeSH D27.720.102.339 - dental ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ...
The cleaning process was used in the conservation of the USS Monitor and the Philadelphia Museum of Art. Due to the blast media ... Dry ice replaces traditional cleaning methods that rely on manual scrubbing and the use of chemical cleaning agents. Dry-ice ... How CO2 Blasting Works "High Density CO2". Retrieved 18 July 2018. Moore, David E., US patents#4,617,064 and #4,744,181 Jet, ... Method of removing meat from bone, 21 January 1960, retrieved 24 September 2018 Method for the removal of unwanted portions of ...
It is due to the scanner being unable to differentiate between a small amount of high-density material (e.g., bone) and a ... The old radiocontrast agents caused anaphylaxis in 1% of cases while the newer, low-osmolar agents cause reactions in 0.01-0.04 ... Payne, Emma Marie (2012). "Imaging Techniques in Conservation" (PDF). Journal of Conservation and Museum Studies. 10 (2): 17-29 ... The contrast agent may induce contrast-induced nephropathy. This occurs in 2 to 7% of people who receive these agents, with ...
As a potential agent of sexual selection, the mating call has many variations that may come into play as a major factor in mate ... As in other frogs, an aggressive call is made when densities are high. This call is a rising trill closely resembling the ... Lighter lines and areas represent periods of bone deposition and rapid growth. These lines allow it to be determined that ... Conservation Biology. 15 (6): 1804-1809. doi:10.1046/j.1523-1739.2001.00307.x. S2CID 26685121. Sullivan, Brian K.; Hinshaw, ...
Vermiculite, polystyrene beads or chemical expansion agents are often added to decrease the density of the finished product and ... It keeps the fractured bone straight. It is used in this way, because when plaster of Paris is mixed with a proper quantity of ... Practical Building Conservation. Mortars, Renders & Plasters. Farnham / Burlington: Ashgate. p. 87. Franz Wirsching "Calcium ... Recent plasters for fire protection either contain cement or gypsum as binding agents as well as mineral wool or glass fiber to ...
Fewer species were found along the first road with density estimates being almost 80% lower than at the second site that which ... Since then, the term has gained broader usage in conservation biology as a global phenomenon. It is estimated that more than 50 ... The results suggested that higher levels of fragmentation within the fish-bone pattern led to the loss of species and decreased ... If seed dispersal agents are targeted by hunters, the effectiveness and amount of dispersal for those plant species will be ...
At night when he sets up camp, Thor eats the meat of the goats, but takes care that all bones remain whole. Then he wraps the ... They have been described as "eating machines" and "biological control agents". There has been a resurgence of this in North ... This form of using goats to clear land is sometimes known as conservation grazing. Since then, numerous public and private ... density, uniformity, fineness, and general body confirmation. Disqualifications include: a deformed mouth, broken down pasterns ...
Animal glue is a widely used adhesive derived from animal parts such as bone or skin. It is a soft adhesive and can appear ... Different grades of plasters are available and vary based on their particle size, setting time, density, expansion, and color ... as is difficulty in manipulating the substance as a workable agent. The most suitable solvent for B-72 is acetone. Unlike ... Care and conservation of ceramic and glass by The Institute of Conservation Conservation of ceramics at the Victoria & Albert ...
Meat and Bone Meal MBR - (i) Master boot record MbS - (i) Mohammad bin Salman (current crown prince of Saudi Arabia) MBSE - (i ... Migratory Bird Conservation Commission (U.S.) MBCS - (i) Multi-Byte Character Set MBE (p) Member of the Order of the British ... Multi-Agent Computing Environment MACHO - (p) MAssive Compact Halo Object MAD (a) Magnetic Anomaly Detector (s) Moroccan dirham ... Main distribution frame Medium-density fiberboard MDG (s) Madagascar (ISO 3166 trigram) (i) UN Millennium Development Goal MDL ...
The cleaning process was used in the conservation of the USS Monitor[16] and the Philadelphia Museum of Art.[17] ... Method of removing meat from bone, 21 January 1960, retrieved 24 September 2018. ... It also reduces or eliminates employee exposure to the use of chemical cleaning agents. ... "High Density CO2". Retrieved 18 July 2018.. *^ Moore, David E., US patents#4,617,064 and #4,744,181 ...
Decellularized allografts have been critical in bone grafts that function in bone reconstruction and replacing of deformed ... Proper conservation of ECM fibers, growth factors, and other proteins is imperative to the progenitor cells differentiating ... EDTA is a chelating agent that binds calcium, which is a necessary component for proteins to interact with one another. By ... The success of decellularization varies based on the components and density of the applied tissue and its origin. The ...
Cell parameters have been calculated for its octahydrate; they lead to conclusion that the density of Pm2(SO4)3·8H2O is 2.86 g/ ... It is not known what human organs are affected by interaction with promethium; a possible candidate is the bone tissues. Sealed ... treating chemical compounds containing Pm3+ ions with strong oxidizing or reducing agents showed that the ion is not easily ... are forbidden by energy conservation. In particular, careful measurements of atomic masses show that the mass difference 150Nd- ...
The reducing agent is commonly a fossil fuel source of carbon, such as coke-or, in earlier times, charcoal. The oxygen in the ... It is too soft to use for structural elements or weapons, though its high density relative to other metals makes it ideal for ... Metals were hard enough to make weapons that were heavier, stronger, and more resistant to impact damage than wood, bone, or ... Environmental Conservation. 1 (2): 123-13 2. doi:10.1017/S0376892900004240. ISSN 1469-4387. S2CID 86686979. Likens, Gene E.; ...
Sheep bones along with a handful of pig, rabbit and cattle bones were also found from this period. Fish bones dominate the ... Ltd.; 1911 Norddeutscher Lloyd, P.P. Lohmann and Co., General Agents; 1911 Gibbs Bright and Co.) made requests to the Collector ... Robertson and Hindmarsh (1998). Conservation Plan of 75 + 75a George Street, The Rocks. Sands, John. Sands Sydney and Suburban ... together with Samson's Cottage wall remains illustrates the development of Sydney at ever higher densities. In this regard, its ...
Vegans may be at risk of low bone mineral density. The Academy of Nutrition and Dietetics and Dietitians of Canada state that ... Scrambled tofu for instance replaces scrambled eggs, but tofu does not act as a binding agent for cakes like raw eggs, ... Paul Watson of the Sea Shepherd Conservation Society called pigs and chicken "major aquatic predators", because livestock eat ... bone mineral density, and fracture risk: a systematic review and meta-analysis". Nutrition Reviews. 77 (1): 1-18. doi:10.1093/ ...
Affected high-density populations had up to 100% mortality in 12-18 months. Between 1996 and 2015, DFTD wiped out 95% of ... Oocyte banking may be useful in the conservation effort for Tasmanian devils, as the survival rate of cryopreserved oocytes is ... The theory that cancer cells themselves could be an infective agent (the Allograft Theory) was first offered in 2006 by Pearse ... Tumours are locally aggressive, destroying the underlying bone of the jaw which interferes with feeding. Tumours may also cover ...
... bone density, and the proliferation of endometrial cells. miR-181 could acquire a resistance to tamoxifen, the drug is ... Tamoxifen acts as an anti-estrogen (inhibitor) in breast tissue, but as an estrogen (stimulating agent) in cholesterol ... "Conservation of small RNA pathways in platypus". Genome Research. 18 (6): 995-1004. doi:10.1101/gr.073056.107. PMC 2413167. ... It has been shown that miR-181 is preferentially expressed in the B-lymphoid cells of mouse bone marrow, but also in the retina ...
The half-life of lead in bone has been estimated as years to decades, and bone can introduce lead into the bloodstream long ... A chelating agent is a molecule with at least two negatively charged groups that allow it to form complexes with metal ions ... Its density, workability, and corrosion resistance were among the metal's attractions. In the 2nd century BC the Greek botanist ... Also, conservation programs exist which routinely capture condors, check their blood lead levels, and treat cases of poisoning ...
Some other bone matrix proteins such as osteopontin and bone sialoprotein use both the first and the second. Direct activation ... Its density of 1.55 g/cm3 is the lowest in its group. Calcium is harder than lead but can be cut with a knife with effort. ... It is also used as a reducing agent in the production of chromium, zirconium, thorium, and uranium. It can also be used to ... so the decay is forbidden by the conservation of angular momentum. While two excited states of 48Sc are available for decay as ...
The identity of the bacterial agent remains unknown. Vitamin E, fluoride, and iodide protect against bone loss associated with ... Population densities are usually below 10 per ha (four per acre) and home ranges vary from 0.23 to 0.37 ha (0.57 to 0.91 acres ... The 2016 IUCN Red List assesses the conservation status of the marsh rice rat as "Least Concern", because it is a common, ... The nasal and premaxillary bones extend back beyond the point where the lacrimal, frontal, and maxillary bones meet. In P. o. ...
... climate change and conservation behaviour". Aquatic Conservation: Marine and Freshwater Ecosystems. 26 (2): 228-232. doi: ... Alpert P, Bone E, Holzapfel C (January 2000). "Invasiveness, invasibility and the role of environmental stress in the spread of ... Decoupling of the relationship between some biocontrol agents and their targets can support invasions. On the other hand, the ... The impact on native species can be altered through population densities of invasive species. Competition interactions and ...
The population density was 48.9 inhabitants per square mile (18.9/km2). There were 8,285 housing units at an average density of ... Banner C. Brummett was appointed County Agent to lay out Nashville in lots to be sold at auction. It was expected that money ... Elkinsville, IN Quadrangle N3900 W8615 /7.5 Field Check 1947 Drainage Map of Brown County, Department of Conservation, State of ... Bean Blossom Belmont Camp Roberts Christiansburg Clarksdale Cornelius Elkinsville Fruitdale Gatesville Gnaw Bone Helmsburg ...
The high amount of calcium (Z = 20) in bones, together with their high density, is what makes them show up so clearly on ... A head CT scan (1.5 mSv, 64 mGy) that is performed once with and once without contrast agent, would be equivalent to 40 years ... The transferred energy can be directly obtained from the scattering angle from the conservation of energy and momentum. ... Bones contain a high concentration of calcium, which, due to its relatively high atomic number, absorbs X-rays efficiently. ...
For example, the EU is bringing in further regulation to set maximum stocking densities for meat chickens by 2010, [needs ... of Environmental Conservation. Retrieved December 3, 2019. Proposition 2, Standards for Confining Farm Animals. Retrieved ... Methods employed to maintain health and improve production may include the use of disinfectants, antimicrobial agents, ... or meat and bone meal). Larger intensive pig farms may be surrounded by farmland where feed-grain crops are grown. ...
The new tail, however, containing cartilage rather than bone, will typically not grow back to the same length as the first one ... It remains uncertain as to how this admixture of invasive alleles to the Carolina anole will affect the conservation of the ... Their preferred habitat is open pine communities with a greater shrub density, it may harbor a greater abundance of anoles ... Daniel F. Culbert; County Extension Agent (2002). "LEAPIN' LIZARDS". University of Florida IFAS extension. Retrieved 2014-05-09 ...
It had an estimated population of 890 as of June 2022, with a population density of 10 people per km2. Otago Peninsula had a ... A particularly fine talismanic whale bone fishook of the 18th century was found there and is now in the Otago Museum. James ... However, at the initial meeting between iwi and agent (the New Zealand Company) the Kai Tahu leaders on 18 June stated their ... Department of Conservation. 2010. Archived from the original on 8 February 2013. Retrieved 16 January 2015. (C. Michael Hogan ...
In advanced cases, exposed areas become infected with bacteria, fungi, and exposed tissue and bone may become necrotic. CD was ... Closeup of desert tortoise at Red Rock Canyon National Conservation Area, 2020 Same desert tortoise at Red Rock Canyon NCA ... URTD is caused by the infectious agents Mycoplasma agassizii and Mycoplasma testudineum, which are bacteria in the class ... The availability of adequate burrow sites influences desert tortoise densities. Each desert tortoise uses about 5 to 25 burrows ...
The diagnosis of brucellosis relies on:[citation needed] Demonstration of the agent: blood cultures in tryptose broth, bone ... Since concentrating animals around food plots accelerates spread of the disease, management strategies to reduce herd density ... Conservation Biology. 8 (3): 645-653. doi:10.1046/j.1523-1739.1994.08030645.x. JSTOR 2386505. Archived from the original (PDF) ... agent US) Bovine brucellosis (agent AA) Caprine brucellosis (agent AM) Agent US was in advanced development by the end of World ...
After an outcry by hunters and conservation ecologists, commercial exploitation of deer became illegal and conservation ... High densities of deer can have severe impacts on native plants and animals in parks and natural areas; however, deer browsing ... When additional amounts of minerals such as calcium are needed in their diet, they can resort to osteophagy, chewing on bones ... and then administering a chemical euthanizing agent or extermination by firearm. A main issue in questioning the humaneness of ...
Byssal threads, used to anchor mussels to substrates, are now recognized as superior bonding agents. A number of studies have ... Williams, James D.; Warren, Melvin L. Jr.; Cummings, Kevin S.; Harris, John L.; Neves, Richard J. (1993-09-01). "Conservation ... where the most common method is to attach mussels to ropes which are hung from a rope back-bone supported by large plastic ... from areas where they have settled naturally to areas where they can be placed in lower densities to increase growth rates, ...
... conservation implications". Conservation Genetics. 16 (1): 195-207. doi:10.1007/s10592-014-0652-6. ISSN 1566-0621. S2CID ... The flukes (lobes of the tail) and dorsal fin are formed of dense connective tissue and do not contain bone or muscle. The ... "Dolphins Deployed as Undersea Agents in Iraq". National Geographic. Retrieved January 18, 2009.. ... Alternatively, or additionally, prey density may be higher in shallow water compared to deep water.[22] ...
"Aquatic Conservation: Marine and Freshwater Ecosystems. 24 (3): 391-409. doi:10.1002/aqc.2432. S2CID 7062322. Archived from the ... Donald G. Reid, Stephen M. Herrero and Thomas E. Code, "River Otters as Agents of Water Loss from Beaver Ponds," Journal of ... but note that to arrive at this figure he assumed a population density throughout the range equivalent to that in Algonquin ... North American beavers have shorter nasal bones than their European relatives, with the widest point being at the middle of the ...
The Sindh Wildlife Conservation Building, located in Saddar, served as a Freemasonic Lodge until it was taken over by the ... "TABLE - 4 AREA, POPULATION BY SEX, SEX RATIO, POPULATION DENSITY, URBAN PROPORTION,HOUSEHOLD SIZE AND ANNUAL GROWTH RATE OF ... In 1995, Ziauddin Hospital was the site of Pakistan's first bone marrow transplant. Karachi municipal authorities in October ... though the modern community dates from the mid 19th century when they served as military contractors and commissariat agents to ...
Population density is extremely low away from the Great Lakes and small towns dominated by enormous farms are the rule, larger ... During World War I the Progressives' moral advice about food conservation was emphasized in large-scale state and federal ... Accompanying many meals is the southern style fluffy biscuit, where the leavening agent is baking soda and often includes ... Typical cuts would include the ribs, brisket, sirloin, flank steak, skirt steak, and t-bone. Historically, Spanish settlers ...
"Human Saliva as a Cleaning Agent for Dirty Surfaces". Studies in Conservation. 35 (3): 153. doi:10.2307/1506167. JSTOR 1506167 ... and which bones would not. Biology/Astronomy: Marie Dacke, Emily Baird, Marcus Byrne, Clarke Scholtz, and Eric Warrant, for ... Koichiro Mizoguchi and Junichi Murakami for determining the ideal density of airborne wasabi (pungent horseradish) to awaken ... for measuring the degree to which human saliva is a good cleaning agent for dirty surfaces. Medical Education: Akira Horiuchi, ...
Seedikkoya, K.; Azeez, P.A.; Shukkur, E.A.A. (2007). "Cattle egret as a biocontrol agent". Zoos' Print Journal. 22 (10): 2864- ... In the dryer habitats with fewer amphibians, the diet may lack sufficient vertebrate content and may cause bone abnormalities ... Kushlan, James A.; Hafner, Heinz (2000). Heron Conservation. Academic Press. pp. 64-65. ISBN 0-12-430130-4. Santharam, V. (1988 ... "Status and distribution of breeding cattle egret and little egret in Amroha using density method" (PDF). Current Science. 88 ( ...
"Saskatchewan Conservation Data Centre - Conservation Database". Saskatchewan Conservation Data Centre. 2007. Retrieved December ... The Bone Gatherer and horse and cart statues are visible from the LRT at Dundurn. Vast quantities of buffalo bones were ... becoming land agents for settlers from the agents. The Wells Land & Cattle Co. purchased land around Davidson, Arm River and ... "Population Density Much Greater on No. 11-12 Highway". Saskatoon Star-Phoenix. Saskatoon, Saskatchewan. August 23, 1949. p. 3. ...
The use of GE soy was also associated with greater conservation tillage, indirectly leading to better soil conservation, as ... van Die, MD; Bone, KM; Williams, SG; Pirotta, MV (2014). "Soy and soy isoflavones in prostate cancer: a systematic review and ... Soybeans contain phytic acid, which may act as a chelating agent and inhibit mineral absorption, especially for diets already ... and produce high-density linkage maps. An SNP array was developed by Song et al. 2013 and has been used for research and ...
Other artefacts included a dodecahedron toy, fragments of amphorae for imported wine, bone hairpins, and samian ware pottery ... ISBN 978-0-7475-9923-4. "Orchard Road Conservation Area Appraisal" (PDF). Stevenage Council. 2009. p. 15. Retrieved 8 February ... agent Keinan Davis (b. 1998), Aston Villa footballer Mark E'Beyer (b. 1984), footballer Albert and Ebenezer Fox (1857-1926, ... high-density town-centre living, substantially improved civic facilities, increased office space and an improved 'public realm ...
At the bone marrow, transferrin is reduced from Fe3+ and Fe2+ and stored as ferritin to be incorporated into hemoglobin. The ... Iron(III) chloride finds use in water purification and sewage treatment, in the dyeing of cloth, as a coloring agent in paints ... ISBN 978-3-527-61234-5. Whitaker, Robert D (1975). "An historical note on the conservation of mass". Journal of Chemical ... and meso-porosity on the single site density and turn over frequency of Fe-N-C carbon electrodes for the oxygen reduction ...
Thomas developed bone marrow transplantation as a treatment for leukemia. John Tyndall (1820-1893): Prominent 19th century ... In physics, he is known for his theories on the conservation of energy, work in electrodynamics, chemical thermodynamics, and ... he thought that a supernatural agent had created the laws of nature. The same is true of virtually all the leading scientists ... his measurement of the Earth's density, and early research into electricity Francis Crick (1916-2004): Nobel-laureate co- ...
Tyvek is a textile-like material created from high-density polyethylene, and works as an alternative to glassine paper, but its ... The more layers utilized the greater the protection from agents of deterioration. It is generally agreed that storage spaces ... Hygroscopic materials such as wood, textiles, and bone, are especially sensitive to changes in humidity, as they swell and ... Collections care, Conservation and restoration of cultural heritage, Museology, Cultural heritage). ...
Ancient Romans kept sheep on a wide scale, and were an important agent in the spread of sheep raising. Pliny the Elder, in his ... Byproducts from the slaughter of sheep are also of value: sheep tallow can be used in candle and soap making, sheep bone and ... Fine wool breeds are those that have wool of great crimp and density, which are preferred for textiles. Most of these were ... In the wake of the environmental and conservation movements, the use of these methods now usually falls under the purview of ...
For density of populations, Cook, 1976a:187. For quotation, see Cook, 1976b:200. For population in 1848, see Cook, 1976a:105. ... They often include a wide variety of shell beads and ornaments as well as frequently used everyday items such as stone and bone ... To call attention to the plight of the California Indians, Indian Agent, reformer, and popular novelist Helen Hunt Jackson ... Its members, including Ohlone tribal members and conservation activists, work together in order to accomplish social and ...
For both community ecology and conservation biology, it would be useful to know where are they in complex trophic networks. An ... "Despite their low energy density, the contribution of jellyfish to the energy budgets of predators may be much greater than ... bone collagen". Archaeological and Anthropological Sciences. 5 (2): 159-182. doi:10.1007/s12520-013-0122-y. S2CID 84866250. ... viruses are being recognised for their role as important agents of mortality, thereby influencing the biogeochemical cycling of ...
Later, the Roman Empire kept sheep on a wide scale, and the Romans were an important agent in the spread of sheep raising ... "Breed Conservation in the United States of America: presentation to the Fifth Congress on Iberoamerican Breeds and Criollos". ... In 1980 New Zealand had the highest density of sheep per capita - sheep outnumbered the human population 12 to 1 (that number ... Russell, Nerissa; Martin, Louise (1998). "Çatalhöyük Animal Bone Report". Çatalhöyük 1998 Archive Report. Çatalhöyük Research ...
Except during times of low rabbit density and abundance of high-quality food, male ranges tend to be larger than those held by ... A second deadly rabbit virus, rabbit hemorrhagic disease (RHD), has been cleared in Australia as a biological control agent and ... In 2005, the Portuguese Institute for Nature Conservation and Forests classified O. cuniculus in Portugal as "near threatened ... with the first real evidence of their presence consisting of a number of bones from the midden of Rayleigh Castle, which was ...
These tend to be the larger (>2 mm) species, mainly in the genera Entomobrya and Orchesella, though the densities on a per ... Insect Conservation and Diversity. 3 (2): 83-91. doi:10.1111/j.1752-4598.2009.00075.x. S2CID 86558143. Heiniger, Charlène; ... and one of the main biological agents responsible for the control and the dissemination of soil microorganisms. In a mature ... "Support for Maintaining Endangered Status For the Bone Cave Harvestman (Texella reyesi)". Retrieved October 6, 2022. Hopkin, ...
"Leopards as Taphonomic Agents in dolomitic Caves-Implications for bone Accumulations in the Hominid-bearing Deposits of South ... Implications for conservation of large apex predators". Biological Conservation. 219: 119-125. doi:10.1016/j.biocon.2018.08.007 ... the greater the leopard population density and the smaller the size of home ranges, but they tend to expand if there is human ... Leopard-like fossil bones and teeth possibly dating to the Pliocene were excavated in Perrier in France, northeast of London, ...
Bone Diseases. Musculoskeletal Diseases. Metabolic Diseases. Alendronate. Physiological Effects of Drugs. Bone Density ... turnover explain the reductions in incidence of nonvertebral fractures that occur during treatment with antiresorptive agents. ... Total hip bone mineral density (BMD). Secondary Outcome Measures : *BMD of femoral neck, trochanter, and lumbar spine. * ... In addition, their bone mineral density (BMD) at the hip needed to be better than it was at the start of FIT ...
Bone Density Conservation Agents / therapeutic use * Bone Diseases, Metabolic / blood * Bone Diseases, Metabolic / chemically ... underwent imaging studies that showed diffuse osteopenia of the long bones and probable rib fractures. All mothers had isolated ...
Bone Density Conservation Agents. Calcium-Regulating Hormones and Agents. To Top. *For Patients and Families ... The investigators will assess baseline characteristics including vitamin D levels, bone turnover rates (measured by C ... presence of abnormal bones on chest x-ray, pulmonary function, opioid analgesic use, overall muscle strength, quality of life ... muscle and bone health, depression, quality of life, pain status and use of opioid pain medications, inflammation and oxidative ...
... on parameters of bone metabolism in postmenopausal women following a 12-month intervention. Postmenopausal women were d … ... Bone Density Conservation Agents / administration & dosage* * Bone and Bones / metabolism* * Calcium, Dietary / administration ... In conclusion, the present study revealed more favorable changes in bone metabolism and bone mass indices for the two vitamin K ... Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy products ...
keywords = "Aged, Alendronate, Bone Density, Bone Density Conservation Agents, Ergocalciferols, Female, Fibroblast Growth ...
... spermatogenesis-blocking agents MeSH D27.505.696.207 - astringents MeSH D27.505.696.242 - bone density conservation agents MeSH ... bone cements MeSH D27.720.102.187 - cariogenic agents MeSH D27.720.102.223 - cariostatic agents MeSH D27.720.102.339 - dental ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ...
keywords = "Bisphosphonate-Associated Osteonecrosis of the Jaw, Bone Density Conservation Agents/adverse effects, Case-Control ... Among the bone metabolism markers, only sclerostin differed between the two groups, being higher in BRONJ+ patients.CONCLUSION ... Among the bone metabolism markers, only sclerostin differed between the two groups, being higher in BRONJ+ patients.CONCLUSION ... Among the bone metabolism markers, only sclerostin differed between the two groups, being higher in BRONJ+ patients.CONCLUSION ...
Bone Density Conservation Agents Medicine & Life Sciences 23% View full fingerprint Cite this. * APA ... Evidence that decreases in bone turnover and increases in bone mass both determine antifracture efficacy. Bone, 18(3 SUPPL.), ... Evidence that decreases in bone turnover and increases in bone mass both determine antifracture efficacy, Bone, vol. 18, no. 3 ... Evidence that decreases in bone turnover and increases in bone mass both determine antifracture efficacy. Bone. 1996 Mar;18(3 ...
... bone recurrence (0·72, 0·60-0·86; 2p=0·0002), and breast cancer mortality (0·82, 0·73-0·93; 2p=0·002). Even for bone recurrence ... Bone fractures were reduced (RR 0·85, 95% CI 0·75-0·97; 2p=0·02). INTERPRETATION: Adjuvant bisphosphonates reduce the rate of ... Primary subgroup investigations were site of first distant recurrence (bone or other), menopausal status (postmenopausal [ ... but the reduction in bone recurrence was more definite (0·83, 0·73-0·94; 2p=0·004). Among premenopausal women, treatment had no ...
Bone Density Conservation Agents 100% * Teriparatide 98% * Vertebroplasty 94% * Compression Fractures 90% ... 深入研究「Comparison of the therapeutic effect of teriparatide with that of combined vertebroplasty with antiresorptive agents for ... Comparison of the therapeutic effect of teriparatide with that of combined vertebroplasty with antiresorptive agents for the ...
... inhibit bone resorption and are widely used for the treatment of bone diseases, including osteoporosis. BPs are also being ... Bone Density Conservation Agents, Chromatography, Liquid, Diphosphonates, Durapatite, Etidronic Acid, Imidazoles, Risedronic ... Bisphosphonates (BPs) inhibit bone resorption and are widely used for the treatment of bone diseases, including osteoporosis. ...
keywords = "Antineoplastic Agents, Bone Density Conservation Agents, Bone Diseases, Clodronic Acid, Diphosphonates, Etidronic ... Acid, Fractures, Bone, Humans, Imidazoles, Multiple Myeloma, Randomized Controlled Trials as Topic", ...
Bone Density Conservation Agents. Public MeSH Note. 2000. History Note. 2000. Date Established. 2000/01/01. Date of Entry. 1999 ...
Browsing by Keyword : Bone Density Conservation Agents / adverse effects. All A B C D E F G H I J K L M N O P Q R S T U V W X Y ...
Bone Density Conservation Agents. CHEBI has role. CHEBI:50646. antiosteoporotic. Drug Use , Suggest Off label Use Form, ,View ... DRUGS FOR TREATMENT OF BONE DISEASES. DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION. Bisphosphonates, combinations ... Toxicity to various agents. 20.92. 15.15. 18. 14448. 212481. 50378177. Nephrogenic anaemia. 20.70. 15.15. 10. 14456. 1695. ...
Animals; Biofilms; Bioware; Bone Density Conservation Agents; Chronic Disease; Cytokines; Drug Evaluation, Preclinical; Humans ... Antimicrobial agents and chemotherapy. Volume: 53. Products: *Bioware bacteria. Keywords: Anti-Bacterial Agents; Bioware; ... The reaction of bone to tumor growth from human breast cancer cells in a rat spine single metastasis model. Year: 2011. ... Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw. Year: 2010 ...
Bone Density Conservation Agents D density Bone Density Bone Density Conservation Agents ... Bone Density Conservation Agents Vasoconstrictor Agents B bone Bone Density Bone Density Conservation Agents ...
Bone Density Conservation Agents.pharmacology.therapeutic use. Diphosphonates.adverse effects. Female. Femoral Fractures. ... Bone 2012; 52(1): 360-5. Abstract: Bone remodelling suppressants like the bisphosphonates reduce bone loss and slow progression ... As remodelling removes damaged bone, when remodelling suppression is protracted, bone quality may be compromised predisposing ... scans of the distal radius and distal tibia were analysed for their cortical bone tissue mineralisation density using new ...
Bone Density Conservation Agents Medicine & Life Sciences 12% * Messenger RNA Medicine & Life Sciences 9% ... Nitrogen-containing bisphosphonates (BIS) are potent inhibitors of bone resorption and are used in the treatment of a number of ... N2 - Nitrogen-containing bisphosphonates (BIS) are potent inhibitors of bone resorption and are used in the treatment of a ... AB - Nitrogen-containing bisphosphonates (BIS) are potent inhibitors of bone resorption and are used in the treatment of a ...
Bone Density Conservation Agents Medicine & Life Sciences 30% View full fingerprint Cite this. * APA ... As well as bone resorption, we need to increase bone formation to prevent osteoporotic fractures, particularly in elderly ... As well as bone resorption, we need to increase bone formation to prevent osteoporotic fractures, particularly in elderly ... As well as bone resorption, we need to increase bone formation to prevent osteoporotic fractures, particularly in elderly ...
Age FactorsAgedAged, 80 and overBone Density Conservation AgentsCost-Benefit AnalysisEtidronic AcidFemaleHip FracturesHumans ... Universal bone densitometry screening combined with alendronate therapy for those diagnosed with osteoporosis is highly cost- ... implications for the use of antiresorptive agents in the old and oldest old. ...
"Bone Density Conservation Agents", "type": "DefinedTerm" }, { "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", "name": " ... ", "bone formation", "phase II trial", "further bone loss", "bone mineral density", "Wnt-\u03b2-catenin pathway", "potential ... ", "bone resorption", "mineral density", "clinical studies", "anabolic agents", "skeletal mass", "skeletal restoration", "novel ... Animal and Phase I clinical studies show tremendous promise for enhancing bone mineral density. However, the full context of ...
Info Bone Density Conservation Agents. * Info Calcium-Regulating Hormones and Agents. Show more categories. Show fewer ...
This agent has also been shown to inhibit the growth of retinoblastomas, and may exhibit some antiproliferative activity ... Bone Density Conservation Agents. Ergocalciferols. Vitamins. Decreased Renal Ca++ Excretion [PE]. Drug toxicity. Hypercalcemia ... We compared the effects of calcitriol and doxercalciferol, in combination with either calcium carbonate or sevelamer, on bone… ... Calcitriol and doxercalciferol are equivalent in controlling bone turnover, suppressing parathyroid hormone, and increasing ...
... bone recurrence (0·72, 0·60-0·86; 2p=0·0002), and breast cancer mortality (0·82, 0·73-0·93; 2p=0·002). Even for bone recurrence ... Bone fractures were reduced (RR 0·85, 95% CI 0·75-0·97; 2p=0·02). INTERPRETATION: Adjuvant bisphosphonates reduce the rate of ... Primary subgroup investigations were site of first distant recurrence (bone or other), menopausal status (postmenopausal [ ... but the reduction in bone recurrence was more definite (0·83, 0·73-0·94; 2p=0·004). Among premenopausal women, treatment had no ...
Antirheumatic Agents. *Bone Density Conservation Agents. _. Top Journals Top journals in which articles about this concept have ... Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update. J Clin Oncol ... Validation of the Surrogate Threshold Effect for Change in Bone Mineral Density as a Surrogate Endpoint for Fracture Outcomes: ... Technetium complexes of diphosphonates have been used successfully as bone scanning agents. ...
Bone Density Conservation Agents. *Depressive Disorder, Major. *Sex Offenses. *Sexually Transmitted Diseases ...
... a systematic review of the literature was augmented by a workshop held in October 2014 for breast cancer and bone specialists ... 18,000 patients supports clinically significant benefits of bisphosphonates on the development of bone metastases and breast ... been studied in randomised trials in early breast cancer to investigate their ability to prevent cancer treatment-induced bone ... adjuvant, bisphosphonates, breast cancer, guidelines, Antineoplastic Agents, Bone Density Conservation Agents, Bone Neoplasms, ...
  • Bisphosphonates (BPs) inhibit bone resorption and are widely used for the treatment of bone diseases, including osteoporosis. (ox.ac.uk)
  • Nitrogen-containing bisphosphonates (BIS) are potent inhibitors of bone resorption and are used in the treatment of a number of medical conditions, including multiple myeloma, breast cancer and osteoporosis. (umn.edu)
  • Both cathepsin K inhibitors and modulators of the RANK-RANKL system, which can reduce bone resorption, are the candidates for the future treatment of osteoporosis. (fujita-hu.ac.jp)
  • As well as bone resorption, we need to increase bone formation to prevent osteoporotic fractures, particularly in elderly patients with low bone turnover. (fujita-hu.ac.jp)
  • Consequently, new therapeutic opportunities have the potential to not only prevent further bone loss but also to augment skeletal mass.Conventional therapies (for example, oestrogens, selective oestrogen receptor modulators, bisphosphonates and calcitonin) for osteoporosis are centred on inhibiting bone resorption, thereby slowing turnover and enhancing mineralization. (springernature.com)
  • They inhibit ectopic calcification and slow down bone resorption and bone turnover. (harvard.edu)
  • Collectively, this study identifies aloin as a potent inhibitor of osteoclastogenesis and bone resorption. (nbrp.jp)
  • Pharmacologic therapy for osteoporosis includes most commonly the use of antiresorptive agents to decrease bone resorption, such as bisphosphonates, denosumab, and the selective estrogen-receptor modulator (SERM) raloxifene. (medscape.com)
  • Bisphosphonates have a high affinity for hydroxyapatite crystals, and by binding at sites of active bone resorption, these agents can inhibit osteoclastic resorption. (medscape.com)
  • Their major pharmacologic action is the inhibition of bone resorption. (medscape.com)
  • Alendronate inhibits osteoclast activity and bone resorption. (medscape.com)
  • It inhibits osteoclastic bone resorption and has some analgesic effects in patients with fractures. (medscape.com)
  • In fact, a study in the Bone journal says that it found good results for people who consumed more water rich in alkalis, particularly in terms of resorption. (observercyprus.com)
  • Resorption of bones is the bodily process of breaking down older bone cells, and then being replaced by newer ones. (observercyprus.com)
  • Drinking Alkaline-rich water which contains water, calcium and bicarbonates reduce resorption of the bones, which helps in maintaining better bone density. (observercyprus.com)
  • Participants in the FLEX study were randomly assigned to receive alendronate (either 5 or 10 mg/day) or matching placebo during the next 5 years, in order to evaluate the effects of continuing or discontinuing alendronate treatment on bone mineral density and biochemical markers of bone turnover. (clinicaltrials.gov)
  • The conventional belief is that osteopenia is the major cause of vertebral fractures and that drug therapy must induce a substantial increase in vertebral bone mineral density (BMD) before the vertebral fracture rate (VFR) is decreased. (elsevier.com)
  • Animal and Phase I clinical studies show tremendous promise for enhancing bone mineral density. (springernature.com)
  • Validation of the Surrogate Threshold Effect for Change in Bone Mineral Density as a Surrogate Endpoint for Fracture Outcomes: The FNIH-ASBMR SABRE Project. (harvard.edu)
  • At the end of pediatric growth (1 and half months) and at an adult age (10 months), the bone morphometric and mineral parameters were measured using μCT in the tibia and skull for the different mice. (cnrs.fr)
  • A GH deficiency can lead to an abnormal level of bodyfat, a decrease in exercise endurance, poor health, reduced bone mineral density, impaired lipid (fat) metabolism, stunted growth, and advanced aging. (fitflex.com)
  • Keay N, Frost M, Blake G, Patel R, Fogelman I. The effects of exercise training on bone mineral accumulation: a 3 year prospective study of peripubertal ballet dancers, musical theatre dancers and control girls. (nickykeayfitness.com)
  • Keay N. The modifiable factors affecting bone mineral accumulation in girls: the paradoxical effect of exercise on bon e. (nickykeayfitness.com)
  • Keay N The effects of exercise training on bone mineral accumulation in adolescent girls. (nickykeayfitness.com)
  • Vitamin D3 is included to complement calcium and magnesium and its role in the maintenance of mineral homeostasis and bone structure. (vitanetonline.com)
  • Calcium is a mineral that works together with phosphorus to build strong bones and teeth. (vitanetonline.com)
  • Magnesium is another mineral that's critical for bones-in fact, it's required for the proper absorption of calcium. (vitanetonline.com)
  • Bone mineral density and content in both cortical and trabecular compartments of subchondral bone decreased in OA rabbits compared to controls, but partially reversed in the TM-OA group. (nature.com)
  • An effective way of preventing osteoporosis is to maximize the attainment of peak bone mineral density (pBMD). (ijstr.org)
  • Bone mineral densities (BMD) at different sites of the skeleton were measured using Dual Energy X-ray Absorptiometer (DXA). (ijstr.org)
  • BACKGROUND: Bisphosphonates have profound effects on bone physiology, and could modify the process of metastasis. (ox.ac.uk)
  • INTERPRETATION: Adjuvant bisphosphonates reduce the rate of breast cancer recurrence in the bone and improve breast cancer survival, but there is definite benefit only in women who were postmenopausal when treatment began. (ox.ac.uk)
  • Bone remodelling suppressants like the bisphosphonates reduce bone loss and slow progression of structural decay. (austin.org.au)
  • Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update. (harvard.edu)
  • Bisphosphonates have been studied in randomised trials in early breast cancer to investigate their ability to prevent cancer treatment-induced bone loss (CTIBL) and reduce the risk of disease recurrence and metastasis. (ox.ac.uk)
  • Using the nominal group methodology for consensus, a systematic review of the literature was augmented by a workshop held in October 2014 for breast cancer and bone specialists to present and debate the available pre-clinical and clinical evidence for the use of adjuvant bisphosphonates. (ox.ac.uk)
  • 18,000 patients supports clinically significant benefits of bisphosphonates on the development of bone metastases and breast cancer mortality in post-menopausal women or those receiving ovarian suppression therapy. (ox.ac.uk)
  • The objective of the present study was to examine the effect of dairy products enriched with calcium, vitamin D(3), and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K(2)) on parameters of bone metabolism in postmenopausal women following a 12-month intervention. (nih.gov)
  • Calcium in the given medicine Calcitriol plays an important role in maintaining bone health, and low levels of calcium. (thetopmedstore.com)
  • This component increases blood levels of calcium by maximizing the absorption of calcium in the kidneys, the absorption of calcium and phosphorus from the intestine, as well as increasing the release of calcium-phosphorus from the bones. (thetopmedstore.com)
  • By binding to calcium salts, alendronate blocks the transformation of calcium phosphate into hydroxyapatite and inhibits the formation, aggregation, and dissolution of hydroxyapatite crystals in bone. (medscape.com)
  • Use of calcitonin-salmon injection is recommended in conjunction with adequate calcium and vitamin D intake to prevent the progressive loss of bone mass. (medscape.com)
  • NOW Calcium & Magnesium Citrate Powder with Vitamin D3 is an optimal bone structure support formula designed by NOW's certified nutritionists. (vitanetonline.com)
  • The citrate forms of calcium and magnesium are highly absorbable and support not only strong bones and teeth but muscle and nerve function as well. (vitanetonline.com)
  • Most people are aware that calcium is important for strong bones, but many don't know why. (vitanetonline.com)
  • When you don't have enough calcium, your body will take it from your bones, which can lead to weak bones or osteoporosis. (vitanetonline.com)
  • We start with easy-to-absorb calcium citrate to promote peak bone density and skeletal strength. (pipingrock.com)
  • D3 is added to enhance bone mineralization and calcium absorption. (pipingrock.com)
  • Bioavailable magnesium citrate rounds out the formula, assisting the body with calcium utilization and bone remineralization. (pipingrock.com)
  • Ten premature infants with hypermagnesemia (4.5+/-0.2 mg/dl), hypocalcemia (6.0 +/-0.3 mg/dl), and high serum alkaline phosphatase (574+/-96 U/l) underwent imaging studies that showed diffuse osteopenia of the long bones and probable rib fractures. (nih.gov)
  • Serum 25-hydroxy-vitamin D (25-OH-D), parathyroid hormone, bone alkaline phosphatase, total procollagen type 1 amino-terminal propeptide, carboxy-terminal collagen crosslinks, Dickkopf WNT signaling pathway inhibitor 1 and sclerostin were measured. (elsevier.com)
  • We hypothesized that the increased bone turnover in osteoporosis also is a major cause of vertebral fractures because of its adverse effects on the microarchitecture of the vertebrae and, thus, that normalization of bone turnover by antiresorptive drug therapy will decrease VFR substantially. (elsevier.com)
  • Riggs, BL, Melton, LJ & O'Fallon, WM 1996, ' Drug therapy for vertebral fractures in osteoporosis: Evidence that decreases in bone turnover and increases in bone mass both determine antifracture efficacy ', Bone , vol. 18, no. 3 SUPPL. (elsevier.com)
  • However, the full context of adverse events with this agent or others that target this pathway has not yet been elucidated.This Review explores the rationale for drug discovery of novel osteoporosis therapies - with a background on limitations of current approaches, enumeration of potential new targets for drug development and the many roads to regulatory approval for these agents. (springernature.com)
  • Mechanisms of Disease: is osteoporosis the obesity of bone? (springernature.com)
  • Osteoporosis is a bone pathology leading to increased fracture risk and challenging the quality of life. (nbrp.jp)
  • Calcitonin is used for the treatment of postmenopausal osteoporosis in women more than 5 years post menopause with low bone mass relative to healthy premenopausal females. (medscape.com)
  • This tends to increase over time as one ages, which leads to density issues, and a variety of health issues such as osteoporosis, among others. (observercyprus.com)
  • Our previous study showed that in experimental osteoporosis, chiropractic manipulation (CM) exerts protective effects on bone. (nature.com)
  • Abstract: Osteoporosis is a disease that causes bones to become weak and brittle. (ijstr.org)
  • The investigators will assess baseline characteristics including vitamin D levels, bone turnover rates (measured by C telopeptide blood levels [CTx]), markers of inflammation and oxidative stress levels in blood, baseline hemoglobin and other laboratory parameters, presence of abnormal bones on chest x-ray, pulmonary function, opioid analgesic use, overall muscle strength, quality of life and depression. (clinicaltrials.gov)
  • As evident from computer-generated three-dimensional graphic plots of data from osteoporotic women treated with placebo, VFR increased as bone turnover increased or as vertebral BMD decreased. (elsevier.com)
  • Estrogen therapy decreased the bone turnover rate to normal and eliminated the relationship between VFR and bone turnover, whereas the inverse relationship with vertebral BMD persisted. (elsevier.com)
  • Over the range of values in the data set, increased vertebral BMD and decreased bone turnover had approximately equal effects in decreasing VFR. (elsevier.com)
  • Calcitriol and doxercalciferol are equivalent in controlling bone turnover, suppressing parathyroid hormone, and increasing fibroblast growth factor-23 in secondary hyperparathyroidism. (semanticscholar.org)
  • The action of aloin was in par with alendronate sodium trihydrate and may provide evidence for its therapeutic potential to treat diseases involving abnormal bone lysis. (nbrp.jp)
  • Teriparatide improves bone quality and healing of atypical femoral fractures associated with bisphosphonate therapy. (austin.org.au)
  • As remodelling removes damaged bone, when remodelling suppression is protracted, bone quality may be compromised predisposing to microdamage accumulation and atypical femoral fractures. (austin.org.au)
  • The aim of this study was to determine whether teriparatide therapy assists in fracture healing and improves bone quality in patients with bisphosphonate associated atypical femoral fractures. (austin.org.au)
  • Teriparatide may assist in healing of atypical fractures and restoration of bone quality. (austin.org.au)
  • However, we can prevent at most 50% of vertebral fractures with these agents. (fujita-hu.ac.jp)
  • We still need to discover new agents to reduce osteoporotic fractures for the better quality of life without fractures. (fujita-hu.ac.jp)
  • Technetium complexes of diphosphonates have been used successfully as bone scanning agents. (harvard.edu)
  • We assessed the prognostic impact of occult bone marrow involvement, determined by flow cytometry and/or polymerase chain reaction, in a population of 117 consecutive patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL) treated with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). (fgfrinhibitors.com)
  • Occult bone marrow involvement predicts severe hematological toxicity and negatively impacts on the PFS and OS of R-CHOP therapy. (fgfrinhibitors.com)
  • It is more common in immunocompromised persons, in bone marrow transplant unit (BMTU) patients, and in those who are in intensive care units (ICUs). (researchgate.net)
  • While considerable progress in survival was attained by optimizing conventional interventions like chemotherapy, radiation, and bone marrow transplantation, it is now widely accepted that a therapeutic plateau has been reached. (biomedcentral.com)
  • MSC preparation from the bone marrow of the iliac crest was laparoscopically injected into the ovaries. (actamedicainternational.com)
  • Use with melphalan extreme caution if your bone marrow reserve have been compromised by prior irradiation or chemotherapy, or if your marrow function is recovering from previous cytotoxic therapy. (veaimpexindia.co.in)
  • In the U.S., Europe, and Australia, they have already started intermittent parathyroid hormone injection and/ or oral strontium ranelate to stimulate bone formation. (fujita-hu.ac.jp)
  • This medication is used to treat hyperparathyroidism or overactive parathyroid glands and metabolic bone disease in people with chronic kidney failure. (thetopmedstore.com)
  • the parathyroid hormone analogues teriparatide and abaloparatide are anabolic agents. (medscape.com)
  • In conclusion, the present study revealed more favorable changes in bone metabolism and bone mass indices for the two vitamin K-supplemented groups, mainly reflected in the suppression of serum levels of bone remodeling indices and in the more positive changes in lumbar spine BMD for these two study groups. (nih.gov)
  • Among the bone metabolism markers, only sclerostin differed between the two groups, being higher in BRONJ+ patients. (elsevier.com)
  • It contains key nutrients that play essential roles in bone metabolism. (vitanetonline.com)
  • ACGIH develops and publishes recommended occupational exposure limits (see TLV ) for hundreds of chemical substances and physical agents. (ornl.gov)
  • The authors hypothesize that the pain in Paget's disease has a primary origin and is correlated to the degree of bone metabolic hyperactivity. (nel.edu)
  • Administration of 20 μg of teriparatide subcutaneously daily for 6 months to 5 of the 14 patients was associated with 2-3 fold increase in bone remodelling markers (p=0.01) and fracture healing. (austin.org.au)
  • High resolution peripheral micro-computed tomography (HRpQCT) scans of the distal radius and distal tibia were analysed for their cortical bone tissue mineralisation density using new software (StrAx1.0, StrAxCorp, Australia) at baseline and 6 months after teriparatide. (austin.org.au)
  • The tropocollagen falls into the class of fibrous proteins and is abundantly found in both soft and hard human's tissues, namely cornea, tendon, cortical bone, and more [ 1 ]. (frontiersin.org)
  • Even for bone recurrence, however, the heterogeneity of benefit was barely significant by menopausal status (2p=0·06 for trend with menopausal status) or age (2p=0·03), and it was non-significant by bisphosphonate class, treatment schedule, oestrogen receptor status, nodes, tumour grade, or concomitant chemotherapy. (ox.ac.uk)
  • Risedronate is a potent antiresorptive agent that does not affect bone mineralization. (medscape.com)
  • J Bone Joint Surg Am after injury: an proof-based report-half I: evaluation 1996;78:581-3. (sayeducate.com)
  • Bone health risk assessment in a clinical setting: an evaluation of a new screening tool for active populations Keay, Francis, Hind MOJSports Medicine 2022;5(3):84-88. (nickykeayfitness.com)
  • This review discusses two paths of energy development side by side: a traditional "hard" path of energy development (i.e., central grid extension powered by fossil fuels and nuclear energy expansion) and a relatively recent "soft" path of energy development, which is based on energy conservation and the deployment of renewable energy resources. (preprints.org)
  • Bone Neoplasms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (viictr.org)
  • white The, a Internet of water by medical agents on governance Indians on benchmarking continuous diet collaboration professionals, quality of Quick people network and software special moment capabilities polarised by abstract digital products. (fussball-und-wetten.de)
  • 2 As a result of early extinctions caused by humans and protohistoric and historic introductions, we suggest that the Mediterranean Basin and its islands are particularly prone to misdirection of efforts towards biodiversity conservation. (blogspot.com)
  • Tumors or cancer located in bone tissue or specific BONES. (viictr.org)
  • Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma. (viictr.org)
  • The collagen triple helix is a ubiquitous biomacromolecule used in acidic aqueous solutions as precursor in the fabrication of artificial compact bone and cornea and in tissue engineering. (frontiersin.org)
  • Trabecular bone parameters in the latter group also showed a significant improvement compared to FM-OA group. (nature.com)
  • Absorption Coefficient, Mass-- The linear absorption coefficient per cm divided by the density of the absorber in grams per cubic centimeter. (cdc.gov)
  • It is frequently expressed as µ/, where µ is the linear absorption coefficient and the absorber density. (cdc.gov)
  • Our results suggest that CM may mitigate OA progression by improving subchondral bone as well as cartilage and synovial membrane status. (nature.com)
  • Nef has the production protein importance of recessive mitotic complexes, is with NF-Y excision Very-low-density Defects, is progression activation and odd immunoglobulin, and is family contraction in different promoters. (evakoch.com)
  • 4 Urgent measures, including refinement of mammal taxonomy, the exclusion of known anthropochorous taxa from conservation lists and implementation of protective legislation, are necessary to maintain the uniqueness and richness of the Mediterranean biodiversity hotspot. (blogspot.com)
  • Biodiversity and Conservation. (unab.cl)
  • 2020. A systematic study of injectable anesthetic agents in the brown anole lizard (Anolis sagrei). (awionline.org)
  • Magnesium Citrate plus Vitamin D3 is an outstanding support formula for healthy bones, good posture and easy mobility -- so buy a bottle for yourself, and extra bottles for your friends and family! (pipingrock.com)
  • 1 The importance of taxonomy to the determination of conservation priorities and actions is widely accepted. (blogspot.com)
  • Although widely accepted in mechanical engineering and materials engineering, this tool as yet to prove its capability within the biomechanics industry with soft tissues, bones and most medical-specific materials. (4spe.org)
  • It is widely used by archaeologists, metal detectorists, in historical artefact and artwork conservation. (zoicpaleotech.com)
  • The Planning Inspector rejected issues related to high density. (residents-association.com)
  • It seems we will now have to show that high density applications will cause harm rather than merely contravene the local planning guidelines. (residents-association.com)
  • The self-bonded boards with high density will be suitable for use as load bearing boards in dry conditions (floor underlayers, interior partitions, furniture, etc. (ocl-journal.org)
  • Although studies have been carried out concerning the use of chitosan as an antioxidant and/or an antimicrobial agent in EC [3, 9-11], none have thoroughly discussed its effect on nutritional properties. (thefreelibrary.com)
  • The polyanionic trap- ping agents form stable intraliposomal complexes with the weakly basic drug, possibly forming precipitates or gels inside the liposome. (binaryoptioninc.com)
  • Bone degradation effect was evaluated by bone pit assay. (nbrp.jp)
  • 2019. Anaesthetic and perioperative management of 14 male New Zealand white rabbits for calvarial bone surgery. (awionline.org)
  • Bone uptake is 20-80%, with the remainder being rapidly excreted through the kidneys. (medscape.com)
  • After the first outbreak, we created an Animal Mortality Monitoring Network in collaboration with the Gabonese and Congolese Ministries of Forestry and Environment and wildlife organizations (Wildlife Conservation Society and Programme de Conservation et Utilisation Rationnelle des Ecosystèmes Forestiers en Afrique Centrale) to predict and possibly prevent human Ebola outbreaks. (cdc.gov)
  • Because of the detrimental effects of stress, studying stress responses is important for this wildlife conservation. (awionline.org)
  • Fish and Wildlife Conservation Commission. (animallaw.info)
  • The following definitions are for the purpose of carrying out the provisions of the rules of the Fish and Wildlife Conservation Commission relating to the possession of wildlife in captivity, in accordance with chapter 68A-6, F.A.C. As used herein, the singular includes the plural. (animallaw.info)