Bone demineralization pathologic. Medical search

Decrease, loss, or removal of the mineral constituents of bones. Temporary loss of bone mineral content is especially associated with space flight, weightlessness, and extended immobilization. OSTEOPOROSIS is permanent, includes reduction of total bone mass, and is associated with increased rate of fractures. CALCIFICATION, PHYSIOLOGIC is the process of bone remineralizing. (From Dorland, 27th ed; Stedman, 25th ed; Nicogossian, Space Physiology and Medicine, 2d ed, pp327-33)

Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.

A tooth's loss of minerals, such as calcium in hydroxyapatite from the tooth matrix, caused by acidic exposure. An example of the occurrence of demineralization is in the formation of dental caries.

A hard thin translucent layer of calcified substance which envelops and protects the dentin of the crown of the tooth. It is the hardest substance in the body and is almost entirely composed of calcium salts. Under the microscope, it is composed of thin rods (enamel prisms) held together by cementing substance, and surrounded by an enamel sheath. (From Jablonski, Dictionary of Dentistry, 1992, p286)

A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.

Therapeutic technique for replacement of minerals in partially decalcified teeth.

A test to determine the relative hardness of a metal, mineral, or other material according to one of several scales, such as Brinell, Mohs, Rockwell, Vickers, or Shore. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Substances that inhibit or arrest DENTAL CARIES formation. (Boucher's Clinical Dental Terminology, 4th ed)

Diagnostic tests conducted in order to measure the increment of active DENTAL CARIES over a period of time.

Production of a radiographic image of a small or very thin object on fine-grained photographic film under conditions which permit subsequent microscopic examination or enlargement of the radiograph at linear magnifications of up to several hundred and with a resolution approaching the resolving power of the photographic emulsion (about 1000 lines per millimeter).

Fluorides, usually in pastes or gels, used for topical application to reduce the incidence of DENTAL CARIES.

Dental caries involving the tooth root, cementum, or cervical area of the tooth.

The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected. (From Jablonski, Dictionary of Dentistry, 1992)

Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.

The susceptibility of the DENTAL ENAMEL to dissolution.

The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.

Progressive loss of the hard substance of a tooth by chemical processes that do not involve bacterial action. (Jablonski, Dictionary of Dentistry, 1992, p296)

Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)

The process whereby calcium salts are deposited in the dental enamel. The process is normal in the development of bones and teeth. (Boucher's Clinical Dental Terminology, 4th ed, p43)

Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.

A genetic metabolic disorder resulting from serum and bone alkaline phosphatase deficiency leading to hypercalcemia, ethanolamine phosphatemia, and ethanolamine phosphaturia. Clinical manifestations include severe skeletal defects resembling vitamin D-resistant rickets, failure of the calvarium to calcify, dyspnea, cyanosis, vomiting, constipation, renal calcinosis, failure to thrive, disorders of movement, beading of the costochondral junction, and rachitic bone changes. (From Dorland, 27th ed)

A condition of an abnormally low level of PHOSPHATES in the blood.

Irradiation directly from the sun.

Condition in which no acceleration, whether due to gravity or any other force, can be detected by an observer within a system. It also means the absence of weight or the absence of the force of gravity acting on a body. Microgravity, gravitational force between 0 and 10 -6 g, is included here. (From NASA Thesaurus, 1988)

Condition under normal Earth gravity where the force of gravity itself is not actually altered but its influence or effect may be modified and studied. (From ASGSB Bull 1992;5(2):27)

Condition wherein the force of gravity is greater than or is increased above that on the surface of the earth. This is expressed as being greater than 1 g.

Acceleration produced by the mutual attraction of two masses, and of magnitude inversely proportional to the square of the distance between the two centers of mass. It is also the force imparted by the earth, moon, or a planet to an object near its surface. (From NASA Thesaurus, 1988)

Specialized PHOTOTRANSDUCTION neurons in the vertebrates, such as the RETINAL ROD CELLS and the RETINAL CONE CELLS. Non-visual photoreceptor neurons have been reported in the deep brain, the PINEAL GLAND and organs of the circadian system.

Locomotor behavior not involving a steering reaction, but in which there may be a turning random in direction. It includes orthokinesis, the rate of movement and klinokinesis, the amount of turning, which are related to the intensity of stimulation.

Condition wherein the force of gravity is less than or is decreased below that on the surface of the earth. This is expressed as being between 0 and 1 g.

Methods of delivering drugs into a joint space.

An esterified form of TRIAMCINOLONE. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions.

A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.

Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.

Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.

A non-neoplastic inflammatory lesion, usually of the jaw or gingiva, containing large, multinucleated cells. It includes reparative giant cell granuloma. Peripheral giant cell granuloma refers to the gingiva (giant cell epulis); central refers to the jaw.

FIBROUS DYSPLASIA OF BONE involving only one bone.

In patients with neoplastic diseases a wide variety of clinical pictures which are indirect and usually remote effects produced by tumor cell metabolites or other products.

A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.

The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)

The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.

Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.

Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum.

Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).

Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.

Exclusive legal rights or privileges applied to inventions, plants, etc.

The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.

Bone mineral density of the proximal femur after unilateral cementless total hip replacement. (1/31)

It was the aim of this study to examine bone mineral density changes in the non-operated contralateral femur of patients undergoing total hip replacement. Bone density in the contralateral femur of 45 patients with an average age of 54 years was measured with the aid of the DEXA technique at one week, 3 and 6 months after total hip replacement. Within the first 3 months there was an average reduction of bone density of 3.9% (3.0%-5.9%). After a further 3 months the average difference was 2.5%. (+info)

Changes in urinary excretion of pyridinium cross-links during Spacelab-J. (2/31)

In SLJ-1 we proposed to study three major objectives. They were; 1. hormonal changes associated with fluid and electrolyte metabolism, 2. the effect of space flight on the circadian rhythms of endocrine and metabolic systems, 3. the changes in the indices of the bone and muscle metabolism during space flight. In this report, the changes in the bone metabolism during Spacelab-J will be presented with a special emphasis on urinary excretion of pyridinium cross-links. Timed urine samples from three Japanese payload specialists were obtained for 3 days from May 19 to 21, 1991 (one year before the launch = L-1 year). Immediately before the launch (L-3 to L-0), urine samples were obtained from a payload specialist who was on board the Space Shuttle Endeavor (PS). During the inflight period (flight from September 3 to 10 in 1992), urine samples from the PS were collected by using Urine Monitoring System (UMS). After the landing, they were obtained from the PS for three days (R+0-R+2). Various parameters related to bone metabolism such as hydroxyproline, pyridinium cross-links and calcium were determined. It was noted that excretion of hydroxyproline decreased during the preflight periods when compared with that in the control L-1 year period. The average excretory rate during control period was 846.2 +/- 198.7 milligrams/hour (mean +/- SD), while those in the preflight 474.6 +/- 171.1 milligrams/hour, suggesting the diminished collagen intake during the preflight period. Average excretion rate of pyridinium cross-links during the first 4 mission days (MD0-MD3) was similar to that of preflight and control L-1 year period. However, it was significantly increased during the last 4 mission days (MD4-MD7). It returned to the preflight level during postflight days (R+0-R+2). Increased urinary excretion of calcium during the last 4 mission days were also observed. These results suggest that increase in bone resorption could occur during relatively short stay in microgravity. (+info)

A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn's disease. (3/31)

BACKGROUND: Osteoporosis is a common complication of Crohn's disease. AIM: To study the effect on the bone mineral density of a bisphosphonate (pamidronate) given intravenously, in combination with oral calcium and vitamin D supplements, compared with oral calcium and vitamin D supplements alone. METHODS: Seventy-four patients with Crohn's disease and low bone mineral density at the lumbar spine and/or hip were randomized to receive either a daily dose of 500 mg of calcium with 400 IU of vitamin D alone or in combination with four three-monthly infusions of 30 mg of intravenous pamidronate over the course of 12 months. The main outcome measure was the change in bone mineral density at the lumbar spine and hip, measured by dual X-ray absorptiometry, at baseline and 12 months. RESULTS: Both groups gained bone mineral density at the lumbar spine and hip after 12 months. There were significant (P < 0.05) changes in the pamidronate group, with gains of + 2.6%[95% confidence interval (CI), 1.4-3.0] at the spine and + 1.6% (95% CI, 0.6-2.5) at the hip, compared with gains of + 1.6% (95% CI, - 0.1-3.2) and + 0.9% (95% CI, - 0.4-2.1) at the spine and hip, respectively, in the group taking vitamin D and calcium supplements alone. CONCLUSIONS: In patients with Crohn's disease and low bone mineral density, intravenous pamidronate significantly increases the bone mineral density at the lumbar spine and hip. (+info)

Rapid hip bone loss in active Crohn's disease patients receiving short-term corticosteroid therapy. (4/31)

BACKGROUND: Uncertainty over whether corticosteroids cause bone loss in patients with Crohn's disease may reflect their short, intermittent use. AIM: We investigated whether a 2-month course of prednisolone is associated with detectable bone loss. METHODS: Fifteen patients with active Crohn's disease and 19 controls with inactive Crohn's disease were recruited. Bone mineral density of the lumbar spine and hip was measured at baseline and 2 and 8 months. RESULTS: At 2 months, significant bone loss was found in patients with active disease (femoral neck -2.7%, P < 0.002; Ward's triangle -3.9%, P < 0.01). Although bone mineral density was still lower at 8 months, these differences were no longer significant (-1.3% and -3.4%, femoral neck and Ward's triangle, respectively). No significant change in hip bone mineral density was observed in controls. Previous corticosteroid use was not significantly associated with baseline bone mineral density, although significant independent associations were observed between weight, site of disease and lumbar spine bone mineral density, and between dietary calcium deficiency and femoral neck and Ward's triangle bone mineral density. CONCLUSION: Significant bone loss at the hip can be detected in patients receiving corticosteroid treatment for 2 months for active Crohn's disease ; however, it remains unclear whether this is because of disease activity or its treatment. This rapid bone loss may represent a risk factor for fracture and justify bone protective therapy. (+info)

Muscle strength is a determinant of bone mineral content in the hemiparetic upper extremity: implications for stroke rehabilitation. (5/31)

Individuals with stroke have a high incidence of bone fractures and approximately 30% of these fractures occur in the upper extremity. The high risk of falls and the decline in bone and muscle health make the chronic stroke population particularly prone to upper extremity fractures. This was the first study to investigate the bone mineral content (BMC), bone mineral density (BMD), and soft tissue composition of the upper extremities and their relationship to stroke-related impairments in ambulatory individuals with chronic stroke (onset >1 year). Dual-energy X-ray absorptiometry (DXA) was used to acquire total body scans on 56 (22 women) community-dwelling individuals (>or=50 years of age) with chronic stroke. BMC (g) and BMD (g/cm2), lean mass (g), and fat mass (g) for each arm were derived from the total body scans. The paretic upper extremity was evaluated for muscle strength (hand-held dynamometry), impairment of motor function (Fugl-Meyer motor assessment), spasticity (Modified Ashworth Scale), and amount of use of the paretic arm in daily activities (Motor Activity Log). Results showed that the paretic arm had significantly lower BMC (13.8%, P<0.001), BMD (4.5%, P<0.001), and lean mass (9.0%, P<0.001) but higher fat mass (6.3%, P=0.028) than the non-paretic arm. Multiple regression analysis showed that lean mass in the paretic arm, height, and muscle strength were significant predictors (R2=0.810, P<0.001) of the paretic arm BMC. Height, muscle strength, and gender were significant predictors (R2=0.822, P<0.001) of lean mass in the paretic arm. These results highlight the potential of muscle strengthening to promote bone health of the paretic arm in individuals with chronic stroke. (+info)

Association between phosphate removal and markers of bone turnover in haemodialysis patients. (6/31)

BACKGROUND: As the main mineral reservoir, bone acts as a calcium (Ca) and phosphate buffering system. Accordingly, phosphate removal by haemodialysis (HD) might be theoretically influenced by bone turnover, as well as by the interaction of regulatory molecules, such as PTH and osteoprotegerin (OPG). The present study investigated the relationship between these variables and phosphate removal by HD. METHODS: Blood samples for serum Ca, phosphate, bicarbonate, intact PTH, PTH (1-84), bone alkaline phosphatase, tartrate-resistant acid phosphatase 5b, OPG and receptor activator of nuclear factor-kappaB ligand (RANKL) were obtained in 28 HD patients. Phosphate removal was measured by a continuous collection of the dialysate. RESULTS: Pre-dialysis serum phosphate concentration is the critical factor in determining dialytic phosphate removal. However, multiple regression analysis reveals that phosphate removal is better explained by a combination of factors than by phosphate concentration alone. In this model, the PTH/OPG ratio is an additional positive factor, whereas age and vitamin D treatment are negative factors. Patients with pre-HD bicarbonate higher than 20 mEq/l had higher serum phosphate and, accordingly, higher phosphate removal; of interest, these individuals also have significant differences in RANKL/OPG. Mean (SD) OPG levels were significantly higher than that in the healthy population (16.2 (12.5) pmol/l; these values correlated with age (r = 0.4, P<0.04). Mean serum RANKL (1.03 (1.02) pmol/l) was within the range of normal individuals. CONCLUSIONS: Dialytic phosphate removal has a crucial, direct relationship with pre-HD plasma phosphate levels. However, the phenomenon of phosphate removal is more precisely explained using a more complex relationship, defined by the interaction between serum phosphate, PTH/OPG, age and vitamin D administration. Serum RANKL levels are first reported in HD patients, and are not different from the normal population. (+info)

Natural calcium isotopic composition of urine as a marker of bone mineral balance. (7/31)

BACKGROUND: We investigated whether changes in the natural isotopic composition of calcium in human urine track changes in net bone mineral balance, as predicted by a model of calcium isotopic behavior in vertebrates. If so, isotopic analysis of natural urine or blood calcium could be used to monitor short-term changes in bone mineral balance that cannot be detected with other techniques. METHODS: Calcium isotopic compositions are expressed as delta(44)Ca, or the difference in parts per thousand between the (44)Ca/(40)Ca of a sample and the (44)Ca/(40)Ca of a standard reference material. delta(44)Ca was measured in urine samples from 10 persons who participated in a study of the effectiveness of countermeasures to bone loss in spaceflight, in which 17 weeks of bed rest was used to induce bone loss. Study participants were assigned to 1 of 3 treatment groups: controls received no treatment, one treatment group received alendronate, and another group performed resistive exercise. Measurements were made on urine samples collected before, at 2 or 3 points during, and after bed rest. RESULTS: Urine delta(44)Ca values during bed rest were lower in controls than in individuals treated with alendronate (P <0.05, ANOVA) or exercise (P <0.05), and lower than the control group baseline (P <0.05, t-test). Results were consistent with the model and with biochemical and bone mineral density data. CONCLUSION: Results confirm the predicted relationship between bone mineral balance and calcium isotopes, suggesting that calcium isotopic analysis of urine might be refined into a clinical and research tool. (+info)

Disease progression in Hutchinson-Gilford progeria syndrome: impact on growth and development. (8/31)

OBJECTIVES: Hutchinson-Gilford progeria syndrome is a rare and uniformly fatal segmental "premature aging" disease that affects a variety of organ systems. We sought to more clearly define the bone and weight abnormalities in patients with progeria as potential outcome parameters for prospective clinical trials. PATIENTS AND METHODS: We collected and analyzed longitudinal medical information, both retrospectively and prospectively, from a total of 41 children with Hutchinson-Gilford progeria syndrome spanning 14 countries, from the Progeria Research Foundation Medical and Research Database at the Brown University Center for Gerontology. RESULTS: In addition to a number of previously well-defined phenotypic findings in children with progeria, this study identified abnormalities in the eruption of secondary incisors lingually and palatally in the mandible and maxilla, respectively. Although bony structures appeared normal in early infancy, clavicular resorption, coxa valga, avascular necrosis of the femoral head, modeling abnormalities of long bones with slender diaphyses, flared metaphyses, and overgrown epiphyses developed. Long bones showed normal cortical thickness centrally and progressive focal demineralization peripherally. The most striking finding identified in the retrospective data set of 35 children was an average weight increase of only 0.44 kg/year, beginning at approximately 24 months of age and persisting through life, with remarkable intrapatient linearity. This rate is >2 SD below normal weight gain for any corresponding age and sharply contrasts with the parabolic growth pattern for normal age- and gender-matched children. This finding was also confirmed prospectively. CONCLUSIONS: Our analysis shows evidence of a newly identified abnormal growth pattern for children with Hutchinson-Gilford progeria syndrome. The skeletal and dental findings are suggestive of a developmental dysplasia rather than a classical aging process. The presence of decreased and linear weight gain, maintained in all of the patients after the age of 2 years, provides the ideal parameter on which altered disease status can be assessed in clinical trials. (+info)

As a result of demineralization, the bones become less rigid. Physical signs include deformities like triradiate pelvis and ... Pathologic fractures due to weight bearing may develop. Most of the time, the only alleged symptom is chronic fatigue, while ... The impairment of bone metabolism causes inadequate bone mineralization. Osteomalacia in children is known as rickets, and ... Osteomalacia is a generalized bone condition in which there is inadequate mineralization of the bone. Many of the effects of ...

https://en.wikipedia.org/wiki/Osteomalacia

... bone demineralization, pathologic MeSH C05.116.198.247.400 - decalcification, pathologic MeSH C05.116.198.371 - mucolipidoses ... MeSH C05.116.070.265 - bone cysts, aneurysmal MeSH C05.116.099.052 - acro-osteolysis MeSH C05.116.099.052.400 - Hajdu-Cheney ... alveolar bone loss MeSH C05.116.264.579 - osteolysis MeSH C05.116.264.579.052 - acro-osteolysis MeSH C05.116.264.579.052.400 - ... fibrous dysplasia of bone MeSH C05.116.099.708.375.199 - cherubism MeSH C05.116.099.708.375.372 - fibrous dysplasia, monostotic ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C05)

The glands are located posterior to the mandibular ramus and anterior to the mastoid process of the temporal bone. They are ... Maintenance of tooth integrity Demineralization occurs when enamel disintegrates due to the presence of acid. When this occurs ... pathologic conditions, and pitfalls". Radiographics. 26 (3): 745-63. doi:10.1148/rg.263055024. PMID 16702452. Nanci A (2018). ... Graft versus host disease after allogeneic bone marrow transplantation may manifest as dry mouth and many small mucoceles. ...

https://en.wikipedia.org/wiki/Salivary_gland

Alveolar bone[edit]. The alveolar bone is the bone of the jaw which forms the alveolus around teeth.[36] Like any other bone in ... "demineralisation", leads to tooth destruction. Saliva gradually neutralises the acids which cause the pH of the tooth surface ... other than dental caries is considered a normal physiologic process but may become severe enough to become a pathologic ... Periodontal ligaments connect the alveolar bone to the cementum. Alveolar bone surrounds the roots of teeth to provide support ...

https://en.wikipedia.org/wiki/Human_tooth

When demineralization of enamel occurs, a dentist can use a sharp instrument, such as a dental explorer, and "feel a stick" at ... Enamel is formed on the tooth while the tooth develops within the jaw bone before it erupts into the mouth. Once fully formed, ... Enamel can be affected further by non-pathologic processes. Enamel is covered by various structures in relation to the ... Demineralization occurs for several reasons, but the most important cause of tooth decay is the ingestion of fermentable ...

https://en.wikipedia.org/wiki/Tooth_enamel

Graft versus host disease after allogeneic bone marrow transplantation may manifest as dry mouth and many small mucoceles.[36] ... Demineralization occurs when enamel disintegrates due to the presence of acid. When this occurs, the buffering capacity effect ... pathologic conditions, and pitfalls". Radiographics : a Review Publication of the Radiological Society of North America, Inc. ... The glands are located posterior to the mandibular ramus and anterior to the mastoid process of the temporal bone. They are ...

https://en.m.wikipedia.org/wiki/Salivary_gland

... and bone demineralization. Until the development of the sacroplasty technique, there was no definitive treatment other than bed ... Aneurysm refers to pathologic dilation of an artery to greater than 1.5 times its normal size. True vascular aneurysms are due ... Other embolizations are also performed for symptom relief or prior to surgery to reduce bleeding Bone Cancer: bone metastases ... to stabilize the bone. These treatments may be palliatively for bone metastases pain or for some cases such as osteoid osteoma ...

https://en.wikipedia.org/wiki/Interventional_radiology

The occlusal view reveals the skeletal or pathologic anatomy of either the floor of the mouth or the palate. The occlusal film ... The bitewing view is taken to visualize the crowns of the posterior teeth and the height of the alveolar bone in relation to ... Radiographic evaluation, (B), however, revealed an extensive region of demineralization within the dentin (arrows) of the ... When there is extensive bone loss, the films may be situated with their longer dimension in the vertical axis so as to better ...

https://en.wikipedia.org/wiki/Dental_radiography

Bone Demineralization, Pathologic / epidemiology * Bone Demineralization, Pathologic / etiology* * Bone Demineralization, ... Longitudinal assessment of bone mineral density in children and adolescents with inflammatory bowel disease J Pediatr ... Objectives: Low bone mineral density (BMD) is recognized as a potential problem in children with inflammatory bowel disease ( ...

https://pubmed.ncbi.nlm.nih.gov/22688562/?dopt=Abstract

... and trabecular bone score (TBS) in hypoparathyroidism over a 2-yea... ... Bone Demineralization, Pathologic. Decrease, loss, or removal of the mineral constituents of bones. Temporary loss of bone ... Bone Demineralization Technique. Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as ... Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE ...

https://www.bioportfolio.com/resources/pmarticle/2120755/Comparative-Effect-of-rhPTH-1-84-on-Bone-Mineral-Density-and-Trabecular.html

Bone Demineralization, Pathologic. Decrease, loss, or removal of the mineral constituents of bones. Temporary loss of bone ... Bone Demineralization Technique. Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as ... Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE ... Bone Mineral Density in Pediatric Epilepsy. What are the effects of the currently used AEDs on bone mineralization in children ...

https://www.bioportfolio.com/resources/pmarticle/2342883/Longan-fruit-increase-bone-mineral-density-in-zebrafish-and-ovariectomized-rat-by.html

Bone Demineralization, Pathologic / physiopathology, prevention & control. Cardiovascular Deconditioning. Erythrocyte Volume. ... 16313354 - Microgravity: the immune response and bone.. 7484174 - Effects of endurance training on left ventricular performance ...

http://www.biomedsearch.com/nih/Biomedical-results-Skylab-Program/11977284.html

As a result of demineralization, the bones become less rigid. Physical signs include deformities like triradiate pelvis[10] and ... Pathologic fractures due to weight bearing may develop. Most of the time, the only alleged symptom is chronic fatigue, while ... decreased bone mass Osteopetrosis unaffected unaffected elevated unaffected[citation needed] thick dense bones also known as ... Pagets disease of bone unaffected unaffected variable (depending on stage of disease) unaffected abnormal bone architecture ...

https://en.wikipedia.org/wiki/Osteomalacia

Bone Demineralization, Pathologic / physiopathology *. Actions. * Search in PubMed * Search in MeSH * Add to Search ... Prevention of Bone Loss and Muscle Atrophy During Manned Space Flight TS Keller et al. Microgravity Q 2 (2), 89-102. Apr 1992. ... the single factor that most limits human survivability in non-Earth environments is the phenomenon of bone demineralization and ... Exposure of astronauts to microgravity leads to the loss of calcium from weightbearing bones. Prolonged exposure, e.g., during ...

https://pubmed.ncbi.nlm.nih.gov/11539500/

... in that many joints with pathologic or radiographic evidence of this disease remain asymptomatic. Because bone demineralization ... J Bone Joint Surg [Am]. 1956;38:695-8.. 18. Felson DT, Anderson JJ, Naimark A, Walker AM, Meenan RF. Obesity and knee ... The cardinal radiographic features of the disease are a loss of joint space and the presence of new bone formation or ...

https://www.aafp.org/afp/2000/0315/p1795.html

... demonstrate progressive diffuse bone demineralization, widening of the growth plates, metaphyseal cupping and fraying, bowing ... Multiple pathologic fractures made the patient wheelchair-bound, and weakness of the thoracic cage was reflected in a reduction ... Bone mass, bone reabsorption parameters, and FGF23 levels normalized. Because the samples had to be sent away, we measured ... Treatment of bone tumours by radiofrequency thermal ablation. Curr Rev Musculoskelet Med. 2009;2(1):43-50pmid:19468917. ...

http://pediatrics.aappublications.org/content/135/6/e1518

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C05)

... and characteristic demineralization of the bone. [3] The pathologic mechanism in RSD is not known, and various treatment ...

https://anesthesiology.pubs.asahq.org/article.aspx?articleid=1948348

Frequent sites of pathologic fracture are the fifth metatarsal of the foot and the distal ulna. Further demonstrations of bone ... and periosteal demineralization; and bone resorption.75 These changes occur from activated osteoclasts, possibly due to the ... Capsaicinsensitive sensory neurons contribute to the maintenance of trabecular bone integrity. J Bone Miner Res. 2005;20(2):257 ... 75 Bone formation and maintenance are dependent on a small fiber innervation, which may be deficient in CRPS.3,77-79 Pathologic ...

https://www.practicalpainmanagement.com/pain/complex-regional-pain-syndrome-systemic-complications?page=0,2

Bone Demineralization, Pathologic 1 0 Bone Diseases, Metabolic 1 0 Breast Neoplasms 1 0 ...

https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=RPL29&geneID=6159&typeSubmit=GO&check=y&typeOption=gene&which=2&pubOrderType=pubD

Bone Marrow-Derived Macrophages; Monocyte-Derived Macrophages. On-line free medical diagnosis assistant. Ranked list of ... Bone Demineralization, Pathologic. 1. + + 333. Foot Diseases. 1. + + 334. Periodontal Pocket. 1. + + ...

https://lookfordiagnosis.com/results.php?symptoms=macrophages%3B%20Bone%20Marrow-Derived%20Macrophages%3B%20Monocyte-Derived%20Macrophages&lang=1&parent=%2F&mode=F

Bone Demineralization, Pathologic. 2818. 18784102 NHERF1 mutations and responsiveness of renal parathyroid hormone.. ... 18445777 Multiple genetic loci for bone mineral density and fractures.. BTF3L1 (690). Fractures, Bone. 11309. 18445777 Multiple ... 18445777 Multiple genetic loci for bone mineral density and fractures.. BTF3L1 (690). Bone Diseases, Metabolic. 10894. 18445777 ... 18445777 Multiple genetic loci for bone mineral density and fractures.. ZBTB40 (9923). Bone Diseases, Metabolic. 10889. ...

http://dnahelix.wikidot.com/validation-results-with-nejm-articles

... initial mild local osteolysis and demineralization of the vertebral body bone and regional depopulation of the vertebral bone ... Clinical, radiologic and pathologic investigations were performed to determine the effect of the heat on the BVN and associated ... Significant bone remodeling in the affected areas had begun by 14 days post-treatment. Bone remodeling was characterized by ... Pathologic involvement of the basivertebral nerve, an intraosseous vertebral nerve found in humans and most mammalian species, ...

https://www.spiedigitallibrary.org/profile/Samit.Patel-28717?SSO=1

... and bone fragility. Early radiologic features include: bony demineralization, pathologic fractures of long bones and ribs, ... bone-specific signs: osteoporosis with a reduction of bone mineral density mainly of the cortical bone, osteitis fibrosa ... bone-specific signs: osteoporosis with a reduction of bone mineral density mainly of the cortical bone, osteitis fibrosa ... Bone films are usually negative. Bone mineral density as measured by DXA is normal or even increased. Nonetheless, few member ...

https://www.osteoporosis.foundation/health-professionals/skeletal-rare-disorders/deranged-calciotropic--parathyroid-hormone

... thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process. ... on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second ... The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as ... produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone ...

https://patents.justia.com/patent/9114191

However, we noted mottling of the flat bones of the skull and postulate that this finding may represent bony demineralization, ... This finding can be seen in genetic disorders, as an anatomic variant,26 and secondary to pathologic states such as chronic ... In the developing calvarium, appositional bone growth increases bone thickness.23 Disturbed appositional bone growth in HGPS ... Bone growth at the calvarial sutures and fontanels occurs via intramembranous bone deposition at suture edges.22 Widened ...

http://www.ajnr.org/node/12049.full.print

Long bone radiographs that may show findings of pathologic fractures, metaphyseal serration, localized demineralization, and ... The Journal of bone and joint surgery. British volume. 1989 Nov [PubMed PMID: 2584243]. ... is released straight into the bloodstream of the fetus causing spirochetemia with spread to most organs including the bones, ...

https://www.statpearls.com/kb/viewarticle/19869/

To prevent treatment-related bone demineralization, osteolysis, and pathologic fractures. *. To treat osteolytic lesions, ... "Indications for Bone-Modifying Agents in Hematology-Oncology." Hematology-Oncology Therapy, 2e Boyiadzis MM, Frame JN, Kohler ... Shalabi R, Frame J.N. Shalabi, Reem Abozena, and James N. Frame.Indications for Bone-Modifying Agents in Hematology-Oncology. ... The American Society of Bone and Mineral Research Task Force has defined osteonecrosis of the jaw (ONJ) as the presence of ...

http://hemonc.mhmedical.com/content.aspx?bookid=1611§ionid=126669160

The signs and symptoms of severe bone disease include bone pain, pathologic fractures, proximal muscle weakness with ... bone erosions and bone resorption of the phalanges, brown tumors and cysts. In the radiography, diffuse demineralization is ... Female , Humans , Male , Aging/metabolism , Bone and Bones/metabolism , Bone and Bones/virology , Fractures, Bone , HIV ... Thus, bone changes related to HIV became an important aspect of these individuals. HIV affects bone remodeling causing bone ...

https://search.bvsalud.org/gim/?lang=en&q=mh:Fractures,+Bone/etiology

Due to demineralization bones become less rigid. Physical signs include deformities like triradiate pelvis[6] and lordosis. The ... Pathologic fractures due to weight bearing may develop. Most of the time, the only alleged symptom is chronic fatigue, while ... Osteomalacia is a generalized bone condition in which there is inadequate mineralization of the bone. Many of the effects of ... Osteomalacia is the softening of the bones caused by defective bone mineralization secondary to inadequate amounts of available ...

http://www.naturalheightgrowth.com/2012/09/12/a-study-on-tumor-induced-osteomalacia/

Bone Demineralization, Pathologic (1). *. Brain Diseases (1). *. Brain Neoplasms (3). *. Brain Pathology (2) ...

https://www.novusbio.com/product-type/peptides-and-proteins?related_diseases=Muscular%20Dystrophy,%20Duchenne

Classic X-ray triad of demineralization, periosteal reaction, and bone destruction. *Radiographic evidence of osteomyelitis ... it is relatively nonspecific and makes differentiating osteomyelitis from other pathologic conditions difficult. ... An acute or chronic infection and inflammation of the bone and bone marrow; can occur as a result of hematogenous seeding, a ... A probe can be passed into the ulcer; however, it is not readily apparent if bone can be contacted with the probe. Laboratory ...

https://smartypance.com/lessons/infectious-diseases/acute-chronic-osteomyelitis-reeldx518/

Instead, there should be a low threshold for bone marrow biopsy for unexplained cytopenias. ... resulting in significant clinical events including bone demineralization, pathologic compression fractures, cytopenias, ... Metastatic bone survey revealed multiple lytic lesions principally involving the cervical spine and right humerus. A bone ... Table 1 Summary of the cases and pathologic features of B-cell acute lymphoblastic lymphoma following immunomodulatory imide ...

https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-6286-9

The signs and symptoms of severe bone disease include bone pain, pathologic fractures, proximal muscle weakness with ... bone erosions and bone resorption of the phalanges, brown tumors and cysts. In the radiography, diffuse demineralization is ... The new term is CKD-MBD (CKD-Mineral and Bone Disorder).. Subject(s). Humans , Bone Diseases/complications , Bone Diseases/ ... Humans , Male , Female , Adult , Bone and Bones , Bone Diseases/complications , Lymphoma, Non-Hodgkin , Costa Rica , Lymphoma, ...

https://search.bvsalud.org/gim/?lang=en&q=mh:Bone+Diseases/complications

Pathologic fractures and bone demineralization in the presence of normal serum concentrations of calcium, phosphorus, and ... involvement of bone, gonads, muscle, skin, and connective tissue, as well as stereotypic behavior, also can occur. Additional ...

https://www.medigoo.com/articles/oculocerebrorenal-syndrome/

C2 Solitary Bone Plasmacytoma Curettage and Vertebral Augmentation in an 83-Year-Old Female: Case Report and Review of Surgical ... Bone survey indicated significant bone demineralization and arthritic changes with repeat demonstration of the lytic lesion at ... Final pathologic diagnosis of the lesion and a bone marrow core biopsy revealed plasma cell myeloma with kappa restriction. ... C2 Solitary Bone Plasmacytoma Curettage and Vertebral Augmentation in an 83-Year-Old Female: Case Report and Review of Surgical ...

https://www.thefreelibrary.com/C2+Solitary+Bone+Plasmacytoma+Curettage+and+Vertebral+Augmentation+in...-a0587974492

... demineralization- occurs in the weight bearing bones of the leg [Os Calcis] and spine. Bone loss has been estimated by calcium- ... the initial pathologic event after the astronauts enter zero gravity occurs in the bone itself, and that changes in mineral ... To the impact of this dynamicity it should be noted that a bone remodeling unit [a coupled phenomena of bone reabsorption and ... This bioelectrical effect in some way may stimulate bone cells and affect bone remodeling. In the early missions, X-ray ...

http://www.novelguide.com/reportessay/science/physical-science/hypogravitational-osteoporosis

OSTEOFORM, containing recombinant (rhPTH [1-34]), enhances bone mineral density and reduces risk for vertebral fracture. (bioportfolio.com)
Bone fracture occurrence is associated with an increasing of morbidity and mortality. (bioportfolio.com)
Correction: Identification of 613 new loci associated with heel bone mineral density and a polygenic risk score for bone mineral density, osteoporosis and fracture. (bioportfolio.com)
It is now clear that most patients with CRPS have suffered either an injury to terminal twigs (peripheral fibers) of C and A-δ nociceptive afferents in soft tissue, or have a frank nerve injury, bone fracture, or have undergone a surgical procedure. (practicalpainmanagement.com)
The age range of 10- to 14 years-old, severe trauma and physical activity were more prevalent among patients with a bone fracture. (bvsalud.org)
Bone loss attributable to hyperparathyroidism increases the risk for fracture. (brainkart.com)
Different radiological changes following SBRT were described, including: remineralization of lytic bone metastases, demineralization of sclerotic bone metastases, pathologic fracture, size progression and response in different lesions, as well as lung fibrosis after SBRT to a rib metastasis. (amegroups.com)
There is a wel-defined lytic lesion of the olecranon with several ridges and a pathologic fracture. (radiologyassistant.nl)
A metabolic bone disease characterized by progressively declining bone density with decreasing bone strength and structure, resulting in increased fracture risk, especially vertebral and hip fractures. (visualdx.com)
a fracture occurring in an area of bone weakened by cancer. (amazonaws.com)
GH deficiency (GHD) may cause secondary osteoporosis associated to low bone mineral density (BMD), impairment of bone turnover and increased fracture rate. (eurospe.org)

In the article Bone Tumors - Differential diagnosis we discussed a systematic approach to the differential diagnosis of bone tumors and tumor-like lesions. (radiologyassistant.nl)
In this article, which is the first in a series of three, we will discuss the most common bone tumors and tumor-like lesions in alphabethic order. (radiologyassistant.nl)
Radiologically, multiple destructive lytic lesions of the skeleton, as well as severe demineralization, characterize multiple myeloma. (medscape.com)
Here we continue with the most common bone tumors and tumor-like lesions in alphabethic order. (radiologyassistant.nl)
Imaging: sharply circumscribed lytic lesions or diffuse demineralization. (radiologyassistant.nl)
Indicates the net result of bone resorption and repair showing osteoblastic, osteolytic and mixed lesions, as well as defining the bone anatomy. (amazonaws.com)
Radionuclide bone scanning is the preferred method for evaluating the entire skeleton for the presence of multiple lesions. (amazonaws.com)
Although whole body MRI has the potential to detect more lesions in the axial skeleton (particularly the spine) than bone scan, it is generally not feasible in most centers due to time constraints. (amazonaws.com)
Multiple myeloma is a disseminated cancer of marrow plasma cells that infiltrates bone to produce lesions throughout the skeleton (flat bones, vertebrae, skull, pelvis, and ribs). (health-care-tips.org)
These lesions cause destruction of bone tissue. (health-care-tips.org)
Despite the fact that the bone structures may appear radiographically normal or osteopénicas, the appearance of conventional lytic lesions with small, discrete, and small. (canceroz.com)
Fibrous dysplasia is a non-neoplastic fibroosseous lesion of the bone, accounting for 7% of benign bone tumours and 2.5% of all bone lesions. (jocr.co.in)
Although this technique has primarily been described in literature to treat bone marrow lesions (BMLs) in the knee joint, this technique has recently been applied to the foot and ankle with comparably successful outcomes. (faoj.org)
These abnormalities can be identified both histologically and on magnetic resonance imaging (MRI) as bone marrow lesions (BMLs) [4-7]. (faoj.org)
A biopsy of the bone marrow or gastrointestinal (GI) tract may be indicated for patients lacking skin lesions in which the diagnosis of systemic mastocytosis is a possibility. (neurologyadvisor.com)
MR imaging revealed symmetric, bilateral, band-like low-signal lesions perpendicular to the medial cortex of the tibiae and corresponding to the only lesions subsequently seen on the bone scan. (lookfordiagnosis.com)

The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). (bioportfolio.com)
Osteomalacia is the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate , calcium , and vitamin D , or because of resorption of calcium. (wikipedia.org)
Clinical features that resemble premature aging include alopecia, joint contractures, progressive mandibular resorption, low bone density, lipoatrophy with limb wasting, and global atherosclerosis. (ajnr.org)
Osteomalacia is the softening of the bones caused by defective bone mineralization secondary to inadequate amounts of available phosphorus and calcium, or because of overactive resorption of calcium from the bone as a result of hyperparathyroidism (which causes hypercalcemia, in contrast to other aetiologies). (naturalheightgrowth.com)
Bone involvement is typically characterized as salt-and-pepper appearance in the skull, bone erosions and bone resorption of the phalanges, brown tumors and cysts. (bvsalud.org)
Charcot neuroarthropathy disease is characterized by increased local bone resorption by osteoclasts in small weightbearing joints, particularly in the foot. (podiatrytoday.com)
ABSTRACT Bone homeostasis depends on the resorption of bones by osteoclasts and formation of bones by the osteoblasts. (semanticscholar.org)
Bone changes in hyperparathyroidism are generally diffuse including subperiosteal resorption or generalized demineralization. (radiologyassistant.nl)
Subperiosteal bone resorption is pathognomonic . (radiologyassistant.nl)
Brown tumor is the result of a more extreme focal bone resorption. (radiologyassistant.nl)
The condition begins when osteoclast function (bone resorption) occurs more than osteoblast function (bone formation). (visualdx.com)
Other treatment that may be considered includes the use of bisphosphonates that bind to bone and inhibit osteoclast induced bone resorption. (cancertherapyadvisor.com)
However, while bone is continuously remodeling by resorption/neoformation during life, tooth's hard tissues are not. (bvsalud.org)

citation needed]Major typical biochemical findings include: Low serum and urinary calcium Low serum phosphate, except in cases of renal osteodystrophy Elevated serum alkaline phosphatase (due to an increase in compensatory osteoblast activity) Elevated parathyroid hormone (due to low calcium) Furthermore, a technetium bone scan will show increased activity (also due to increased osteoblasts). (wikipedia.org)
Serum bone formation markers were high: osteocalcin 52 ng/mL (reference range 4-12 ng/mL), alkaline phosphatase 23 μg/L (reference range 7.5-17 μg/L), and bone-specific alkaline phosphatase 36.5 μg/L (reference range 7.5-17 g/L). Tubular reabsorption of phosphate measured by ratio of the renal tubular maximum reabsorption rate of phosphate to the glomerular filtration rate (TmP/GFR) was normal initially ( Fig 3 ). (aappublications.org)
Criteria for diagnosis of SBP include a radiographic lytic lesion, monoclonal plasma cell infiltration on biopsy, histologically normal bone marrow aspirate, absent or low concentration of serum and urine protein on electrophoresis, and absence of anemia, hypercalcemia, or renal impairment [1,5]. (thefreelibrary.com)
Active (symptomatic) PCM is related to the expansion and infiltration of plasma cells within the bone marrow and other end-organs, resulting in significant clinical events including bone demineralization, pathologic compression fractures, cytopenias, hypercalcemia, and renal dysfunction. (biomedcentral.com)
Fever, bone pain, osteitis fibrosa cystica diffuse demineralization, pathologic fractures, diffuse bone demineralization, renal insufficiency the most common type of esodeviation is usually unilateral. (bac.edu)
Hyperparathyroidism, which is caused by overproduction of parathyroid hormone by the parathyroid glands, is characterized by bone decalcification and the development of renal calculi (kid-ney stones) containing calcium. (brainkart.com)
An elevated serum calcium level alone is a nonspecific finding because serum levels may be altered by diet, medications, and renal and bone changes. (brainkart.com)
Treatment includes rehy-dration with large volumes of intravenous fluids, diuretic agents to promote renal excretion of excess calcium, and phosphate therapy to correct hypophosphatemia and decrease serum cal-cium levels by promoting calcium deposit in bone and reducing the gastrointestinal absorption of calcium. (brainkart.com)
The most relevant clinical findings were bone demineralization, high level of parathyroid hormone (PTH), normophosphatemia, normal ionized calcium, and low total thyroxine (tT4) with a normal renal function. (hindawi.com)
Renal patients with chronic acidemia may show signs of skeletal problems as calcium and phosphate are released from bone to help with the buffering of acids. (diabetestalk.net)
Hypercalcemia is the consequence of increased absorption of calcium from the intestinal tract (a primary function of calcitriol) or its increased reabsorption from renal glomerular filtrate or bone (due to excessive PTH secretion or functional activity, increased calcitriol levels, exuberant osteoclastogenesis due to inflammatory cytokines), or decreased rate of bone formation in the presence of continued bone reabsorption (immobilization). (cancertherapyadvisor.com)

Rickets in children leads to limbs and bones being bent or twisted, causing bow legs, knock knees, and cranial, pelvic, and spinal deformities. (naturalheightgrowth.com)
Bone pain, skeletal deformities and pathological fractures are features of OFC. (bvsalud.org)
Types III and IV are moderate to severe forms with bone deformities, whereas hearing impairment is less common in these types. (ajnr.org)
In secondary hyperparathyroidism, patients may show signs of calcium imbalance such as deformities of the long bones. (thefreedictionary.com)

Bone disease in severe primary hyperparathyroidism (PHPT) is described classically as osteitis fibrosa cystica (OFC). (bvsalud.org)

Sequences of comparative radiographs taken 1 year apart (January 2008 and February 2009) demonstrate progressive diffuse bone demineralization, widening of the growth plates, metaphyseal cupping and fraying, bowing of long bones, and multiple rib fractures with collapse of the thoracic cage. (aappublications.org)

Aneurysmal bone cyst typically presents as a painful expansile or 'aneurysmal' well-defined osteolytic lesion in a patient younger than 30 years. (radiologyassistant.nl)
On the left images of an aneurysmal or expansile well-defined osteolytic bone lesion in the fibula. (radiologyassistant.nl)
The plain radiograph shows a layered periosteal reaction and Codman triangle in direct relationship to an expansile lytic lesion with a thin peripheral bone shell. (radiologyassistant.nl)
CT also reveals the subperiosteal origin of the lesion with secondary involvement of the cortical bone. (radiologyassistant.nl)
Young patient with a lobulated lytic lesion within the anterior cortical bone of the proximal tibia. (radiologyassistant.nl)
Axail CT image prior to biopsy demonstrates the lytic appearance of the lesion within the thickened cortical bone. (radiologyassistant.nl)
It resembles a primary bone tumor or metastatic lesion. (radiologyassistant.nl)
Here a bone lesion in a patient with known NHL. (radiologyassistant.nl)
In a patient younger than 40 years a sclerotic lesion is usually an incidental benign finding like an ossified NOF, bone island, osteoid osteoma or infection. (radiologyassistant.nl)
Radiographically, more than one lytic lesion unfavorable of the skeleton, in addition to the demineralization severe, symbolize more of a myeloma. (canceroz.com)
This osteoarthritis is often accompanied by a coinciding bone marrow lesion (BML) which has been shown to result in poorer patient outcomes. (faoj.org)

Skeletal radiographs revealed typical rachitic findings ( Fig 2 ), and bone mineral density scans showed a z score of −2.92 SD at the lumbar spine. (aappublications.org)
On plain radiographs often ballooning with very thin peripheral bone shell and frequently internal thin bony ridges. (radiologyassistant.nl)
Also, it is reserved for patients with positive bone scans and negative radiographs in order to clarify pathology. (amazonaws.com)
What are the radiological modes of presentation of secondary bone tumors in plain radiographs? (amazonaws.com)
Radiographs indicate marked demineralization. (medscape.com)
Demineralization of diaphyses and metaphyses is evident on plain radiographs. (cancertherapyadvisor.com)

Comparative Effect of rhPTH(1-84) on Bone Mineral Density and Trabecular Bone Score in Hypoparathyroidism and Postmenopausal Osteoporosis. (bioportfolio.com)
To evaluate the relationship between bone mineral density (BMD) and magnetic susceptibility, and between proton density fat fraction and susceptibility, in inflamed trabecular bone. (bioportfolio.com)
Lumbar Spine Bone Mineral Apparent Density in Children: Results from the Bone Mineral Density in Childhood Study. (bioportfolio.com)
Dual-energy X-ray absorptiometry (DXA) is a cornerstone of pediatric bone health assessment, yet differences in height-for-age confound the interpretation of areal bone mineral density (aBMD) measures. (bioportfolio.com)
Protease inhibitors (PI) have been associated with an acceleration of bone mineral density loss in HIV-infected individuals because of an enhanced osteoclast activity, although some contro. (bioportfolio.com)
Actual bone density would be expressed in grams per milliliter. (bioportfolio.com)
Bone density is an important predictor for OSTEOPOROSIS. (bioportfolio.com)
Longan fruit increase bone mineral density in zebrafish and ovariectomized rat by suppressing RANKL-induced osteoclast differentiation. (bioportfolio.com)
bone mineral density in zebrafish and ovariectomized rat by suppressing RANKL-induced osteoclast differentiation. (bioportfolio.com)
Introduction: The given article is concerned with peculiarities of the change in the bone mineral density of the jaw bones in the dynamics of bone structure growth in the locomotor apparatus of orthod. (bioportfolio.com)
Association of bone mineral density with hemoglobin and change in hemoglobin among older men and women: The cardiovascular health study. (bioportfolio.com)
We hypothesized that declines in Hgb levels are associated with bone mineral density (BMD). (bioportfolio.com)
The relationship between volumetric bone mineral density and coronary calcification in men and women - results from the Copenhagen General Population Study. (bioportfolio.com)
The association between low bone mineral density (BMD) and the presence of coronary artery calcium (CAC) as a marker of atherosclerosis is unclear. (bioportfolio.com)
Reduced bone mineral density (BMD) and increased risk of fractures are present in many younger and middle-aged women wi. (bioportfolio.com)
The aim of this study is to investigate the effects of soluble corn fiber (SCF) on bone mineral content (BMC) and bone mineral density (BMD) in pre-pubertal boys and girls. (bioportfolio.com)
Imaging modalities MRI and CT can be implemented to non-invasively describe treatment region and volume, marrow cellular effects, and bone density alterations immediately following RF treatment and during convalescence. (spiedigitallibrary.org)
18445777 Multiple genetic loci for bone mineral density and fractures. (wikidot.com)
Primary hyperparathyroidism associated with MEN1 is characterized by: early age at onset, greater reduction in bone mineral density than primary hyperparathyroidism not associated with MEN1, and an equal male/female ratio (1:1 vs. 1:3). (osteoporosis.foundation)
Being out in the sun, taking around 10,000 IU of Vitamin D for up to 8 weeks, and drinking more milk would help keep the bones from loosing more strength and density. (naturalheightgrowth.com)
This dynamic system responds to mechanical stress, or lack of it, by increasing the bone mass/density or decreasing it as per the demand on the system. (novelguide.com)
a person dealing with increased mechanical stress will respond with increased mass/density of the bone and a person who leads a sedentary life will have decreased mass/density of bone. (novelguide.com)
Bone mineral density is usually extremely low in OFC, but it is reversible after surgical cure. (bvsalud.org)
a person dealing with increased mechanical stress will respond with increased mass / density of the bone and a person who leads a sedentary life will have decreased mass/density of bone but the right amount to support his structure against the mechanical stresses she/she exists in. (benjaminbarber.org)
The peer review journal studies mainly explored using supported standers for improving bone mineral density (BMD), cardiopulmonary function, muscle strength/function, and range of motion (ROM). (easystand.com)
A comprehensive literature search was performed from January 2004 to January 2020 considering the bone mineral density (BMD) of the lumbar spine (LS) as the main outcome. (e-jbm.org)
Osteoporosis was defined as having a bone mineral density with a T -score of less than −2.5 standard deviation. (bjorl.org)
Random-effects model and pooled hazard ratio, risk ratio, or odds ratio of hearing loss with 95% confidence intervals were compared between normal bone mineral density and low bone mineral density or osteoporosis. (bjorl.org)
Overall, there was a statistically significant increased odds of hearing loss in the low bone mineral density or osteoporosis group with odds ratio of 1.20 (95% confidence intervals 1.01-1.42, p = 0.04, I 2 = 82%, P heterogeneity = 0.01). (bjorl.org)
One of the patients who presented with increased bone density was misdiagnosed as possible fluorosis. (lookfordiagnosis.com)

The signs and symptoms of severe bone disease include bone pain, pathologic fractures, proximal muscle weakness with hyperreflexia. (bvsalud.org)
Other locations include the proximal humerus or spine, but many other bones are possible. (radiologyassistant.nl)
There is a second lucency separately more proximal within the cortical bone. (radiologyassistant.nl)
It may occur in any bone but is most common in the proximal femur, tibia, ribs, and skull. (jocr.co.in)
It can cause repeated pathologic fractures or severe bone deformity, such as the "shepherd's crook" varus deformity of the proximal femur. (jocr.co.in)
It leads to destruction of cartilage and bone at multiple joints with a distal to proximal preference. (bloodjournal.org)
bence jones protein (lambda sub-type) was present in the urine at a concentration of 0.58 g/L. Monocytic cells in the bone marrow and proximal tubular cells in the kidney contained cytoplasmic crystalline inclusions. (lookfordiagnosis.com)

Musculoskeletal symptoms accompanying hyperparathyroidism may result from demineralization of the bones or bone tumors composed of benign giant cells resulting from overgrowth of osteoclasts. (brainkart.com)

Exposure of astronauts to microgravity leads to the loss of calcium from weightbearing bones. (nih.gov)
However, allograft bone grafts may present disadvantages relating to histocompatibility issues (e.g., rejection by recipient immune system), the potential harboring of infectious agents, and may also include bone with poor malleable or mechanical characteristics (e.g., elasticity, compressibility, resiliency, and the like) due to high calcium and mineral content. (justia.com)
In addition to providing the rigid infrastructure, it protects vital organs like the brain], serves as a complex lever system, acts as a storage area for calcium which is vital for human metabolism, houses the bone marrow within its mid cavity and is capable of changing its architecture and mass in response to outside and inner stress. (novelguide.com)
In Skeletal systems whose mass represent a dynamic homeostasis in 1g weight- bearing, when placed in microgravity for any extended period of time requiring practically no weight bearing, the regulatory system of bone/calcium reacts by decreasing its mass. (novelguide.com)
Bone loss has been estimated by calcium-balance studies and excretion studies. (novelguide.com)
An increased urinary excretion of calcium , hydroxyproline & phosphorus has been noted in the first 8 to 10 days of microgravity, suggestive of increased bone re-absorption. (novelguide.com)
Pathologic fractures and bone demineralization in the presence of normal serum concentrations of calcium, phosphorus, and vitamin D metabolites. (medigoo.com)
A combination of calcitonin and corticosteroids has been ad-ministered in emergencies to reduce the serum calcium level by increasing calcium deposition in bone. (brainkart.com)
It is also a repository for calcium and other elements that get deposited in bone as it mineralizes during bone formation and are released from bone when it is being remodeled. (frontiersin.org)
In this way, bone participates in the control of calcium levels in the blood and tissues ( 1 ) to mediate numerous cellular functions, including contraction of skeletal and cardiac muscles ( 2 ). (frontiersin.org)
Most of the symptoms of hyperparathyroidism are those present as a result of hypercalcemia, such as kidney stones , osteoporosis, or bone degradation resulting from the bones giving up calcium. (thefreedictionary.com)
Because the person may have bone demineralization and may lose large amounts of calcium into the blood and urine, he or she is a prime candidate for kidney stones, nephrocalcinosis, and, eventually, kidney failure due to excessive calcium in the blood. (health-care-tips.org)

The impairment of bone metabolism causes inadequate bone mineralization . (wikipedia.org)
Journal of Bone Metabolism 2020;27(3):175-186. (e-jbm.org)
Clinical profile and indicators of bone metabolism of the participants were evaluated regarding effect size, homogeneity, and consistency. (e-jbm.org)
The effects of treatment with recombinant human Growth Hormone (rhGH) on bone metabolism are controversial. (eurospe.org)
it should be repeated at the end of treatment in order to evaluate its effect on bone metabolism. (eurospe.org)
Bone metabolism is dynamic, in concert with Wolff's law, and a normal subchondral bone plate displays the same capacity to increase in thickness according to physiologic loading [3]. (faoj.org)

[ 8 ] Patients suspected of having multiple myeloma based on bone marrow aspirate results or hypergammaglobulinemia should undergo a radiographic skeletal survey. (medscape.com)
[ 9 ] MRI is the gold-standard imaging modality for detection of bone marrow involvement and the preferred imaging technique to rule out spinal cord compression in patients with multiple myeloma, whereas PET/CT provides valuable prognostic data and aids in assessment of response to therapy. (medscape.com)
range, 44-83 years) with multiple myeloma proven by bone marrow biopsy. (medscape.com)
The etiology of multiple myeloma is the proliferation of monoclonal B cells in plasma, with subsequent infiltration of the bone marrow and rise of an immunoglobulin single and their fragments within the serum and urine. (canceroz.com)
8] patients suspected of having multiple myeloma based entirely on the results of bone marrow aspirate or hypergammaglobulinemia, you must go through a survey skeletal x-ray. (canceroz.com)
Multiple myeloma skull x ray - Shorrt et al compared the puppy FDG, MRI of the whole body, and the aspiration and biopsy of the bone marrow in 24 patients (thirteen women, 11 boys, and sixty-seven years of age, range, 44, and fourscore and three years old) with more than one myeloma proven By bone marrow biopsy. (canceroz.com)

The amount of mineral per square centimeter of BONE. (bioportfolio.com)
Removal of mineral constituents or salts from bone or bone tissue. (bioportfolio.com)
Decrease, loss, or removal of the mineral constituents of bones. (bioportfolio.com)
Temporary loss of bone mineral content is especially associated with space flight, weightlessness, and extended immobilization. (bioportfolio.com)
In addition to low systemic levels of circulating mineral ions necessary for bone and tooth mineralization, accumulation of mineralization-inhibiting proteins and peptides (such as osteopontin and ASARM peptides) occurs in the extracellular matrix of bones and teeth, likely contributing locally to cause matrix hypomineralization (osteomalacia). (wikipedia.org)
Osteoporosis is a condition characterized by a decreased bone mass, involving loss of both mineral and protein matrix components to a level below the amount which is necessary to maintain the structural integrity of the skeleton. (novelguide.com)
Boy Frame, M..D., a member of NASA's Life Science Advisory Committee [LSAC] postulated that 'the initial pathologic event after the astronauts enter zero gravity occurs in the bone itself, and that changes in mineral homeostasis and the calcitropic hormones are secondary to this. (novelguide.com)
In the later Apollo, Skylab and Spacelab missions Photon absorptiometry (a more sensitive indicator of bone mineral content) was utilized. (novelguide.com)
The results of these studies indicated that bone mass [mineral content] was in the range of 3.2% to 8% on flight longer than two weeks and varying directly with the length of the stay in microgravity. (novelguide.com)

Inclusion of at least these bones is important for both diagnosis and staging . (medscape.com)
The differential diagnosis of osteogenesis imperfecta tarda affecting the temporal bone includes otosclerosis, Paget disease, otosyphilis, and Camurati-Engelmann disease. (ajnr.org)
We describe serial CT and MR imaging findings of the temporal bone in a patient with genetically proved Van der Hoeve-de Kleyn syndrome and discuss the key distinguishing features in the radiologic and clinical differential diagnosis. (ajnr.org)
The inclusion of at least those bones is essential for both the diagnosis and for staging. (canceroz.com)
Two other patients were referred to us with the diagnosis of possible metastatic bone disease attributable to polyostotic areas of increased radio nuclide uptake caused by pseudofractures. (lookfordiagnosis.com)
Gastric mucosal calcinosis is a very rare pathologic diagnosis and we aimed to present this case with reference to the literature data. (heighpubs.org)

Clinical, radiologic and pathologic investigations were performed to determine the effect of the heat on the BVN and associated tissues. (spiedigitallibrary.org)
Clinical definitions of the various myeloma subtypes have been updated, as have the imaging definitions of what constitutes bone marrow disease and individual bony involvement. (medscape.com)
There is no consensus as to the utility of PET scans in the clinical evaluation of bone metastases. (amazonaws.com)
The present study performed a systematic review and meta-analysis of clinical trials using bisphosphonates for bone demineralization in human immunodeficiency virus (HIV) patients. (e-jbm.org)
In addition, the differing pathologic mechanisms, and the great variety of existing treatments hinder the clinical management of these patients. (medsci.org)

What are the effects of the currently used AEDs on bone mineralization in children and adolescents between the ages of 8 to 18? (bioportfolio.com)
Osteomalacia is a generalized bone condition in which there is inadequate mineralization of the bone. (wikipedia.org)
Bone remodeling was characterized by conventional osteoblast proliferation, osteoid deposition, and mineralization. (spiedigitallibrary.org)
6 Collagen crosslinking within bone is known to affect bone stiffness and Young's modulus independent of the bones' mineralization and microarchitecture. (podiatrytoday.com)
Investigation of the variables which might influence bone mineralization revealed no differences in age, sex, physical activity, sunshine exposure, or dietary intake of vitamin D between the osteomalacia and nonosteomalacia groups. (easystand.com)

Chloroquine also inhibits bone destruction induced by ovariectomy and parathyroid hormone in mice in vivo . (frontiersin.org)

Utah revealed 67 patients with osteomalacia as defined by hypocalcemia, hypophosphatemia, elevated serum alkaline phosphatase levels, and appropriate bone changes. (easystand.com)

Pathologic involvement of the basivertebral nerve, an intraosseous vertebral nerve found in humans and most mammalian species, may play a role in some forms of back pain. (spiedigitallibrary.org)
Usually bone involvement in known NHL, but may uncommonly arise as an isolated primary bone tumor. (radiologyassistant.nl)
Scientific definitions of the various subtypes of myeloma have been the day, as well as definitions of the image of what constitutes the disease of the bone marrow, and involvement of bone of the man or woman. (canceroz.com)
Bone involvement may cause pain, which causes infants to refuse to move one or more affected extremities (pseudoparalysis of Parrot). (cancertherapyadvisor.com)

[2] The syndrome of RSD includes manifestations such as severe burning pain, hyperpathia, allodynia, hyperhidrosis, edema, vasomotor instability, and characteristic demineralization of the bone. (asahq.org)

The use of bone materials to promote bone healing after facture, bone loss, infection, tumor, or other pathologic conditions is well known to those skilled in the art. (justia.com)
Solitary bone plasmacytoma (SBP) is a localized plasma cell tumor accounting for 2-5% of plasma cell malignancies. (thefreelibrary.com)

Pathologic fractures due to weight bearing may develop. (wikipedia.org)
The single most costly medical problem at the school is the treatment of pathologic bone fractures due to demineralized bone. (easystand.com)

OSTEOPOROSIS is permanent, includes reduction of total bone mass, and is associated with increased rate of fractures. (bioportfolio.com)
Hormones also play a major role as seen in postmenopausal females osteoporosis (lack of estrogen) in which the rate of bone reformation is usually normal with the rate of bone re-absorption increased. (novelguide.com)
There is also significant evidence derived primarily from rodent studies that seem to suggest decreased bone formation as a factor in hypogravitational osteoporosis. (novelguide.com)
It also occurs in many bone diseases such as psoriatic arthritis, rheumatoid arthritis and osteoporosis. (podiatrytoday.com)
Osteoporosis: a condition characterized by an absolute decrease in the amount of bone present to a level below which it is capable of maintaining the structural integrity of the skeleton. (benjaminbarber.org)

In addition to ablation of teh basivertebral nerovascular bundle, the areas receiving the greatest treatment demonstrated initial mild local osteolysis and demineralization of the vertebral body bone and regional depopulation of the vertebral bone marrow cellular elements. (spiedigitallibrary.org)

TRAF3 protein levels decrease in bone and bone marrow during aging in mice and humans. (frontiersin.org)

Our goal was to expand the scope of structural bone and soft-tissue craniofacial abnormalities in HGPS through CT or MR imaging. (ajnr.org)
The system consists of Bone, a highly specialized and dynamic supporting tissue which provides the vertebrates its rigid infrastructure. (novelguide.com)
It consists of specialized connective tissue cells called osteocytes and a matrix consisting of organic fibers held together by an organic cement which gives bone its tenacity, elasticity and its resilience. (novelguide.com)
Osteoclasts are among the three main cells present in bone and they resorb bone tissue. (podiatrytoday.com)
As early as in the 1920s, it was also recognized that administration of these doses was associated with soft tissue calcification in some children [ 4 ], indicating that beneficial vitamin D effects on bone health may lead to adverse effects on the cardiovascular system. (hindawi.com)
n a pathologic disturbance of a tissue, with loss of con-tinuity, enlargement, and/or function. (thefreedictionary.com)
This results in increased and irreversible bone porosity in the cortical and cancellous (trabeculae) osseous tissue. (visualdx.com)
Osteoradionecrosis (soft tissue and bone necrosis) can be spontaneous or secondary to trauma, extractions, or dental prostheses. (1stdentist.com)
It is characterized by the metaplastic replacement of the medullary component of one bone (monostotic) or less commonly of several bones (polystotic) with fibrous tissue and irregular osteoid formation. (jocr.co.in)
Portions of the bone are replaced by fibrous connective tissue and poorly formed trabecular bone. (jocr.co.in)
Complicated: bone fragments have damage other organs or tissue. (studystack.com)
Comminuted: small fragments of bone are broken from fractured shaft and lie in surrounding tissue. (studystack.com)

This paper examines the physiological changes associated with microgravity conditions with particular reference to the weightless demineralizatoin of bone (WDB). (nih.gov)
Bone remodeling is a normal physiological process that maintains skeletal integrity after skeletal development by removing small foci of damaged or effete bone from bone surfaces and replacing them with new bone ( 3 , 4 ). (frontiersin.org)

We reviewed the radiological images of eight selected cases after SBRT to nonspine bone metastases and a number of characteristic findings were highlighted. (amegroups.com)
Characteristic wedge-shaped demineralization of the upper medial tibial metaphysis is known as Wimberger sign. (cancertherapyadvisor.com)

In the radiography, diffuse demineralization is observed, along with pathological fractures, particularly in the long bones of the extremities. (bvsalud.org)
The serrated appearance at the epiphyseal margin of long bones is called Wegner sign. (cancertherapyadvisor.com)

Passive standing has been shown to counteract many of the effects of chronic immobilization and spinal cord injury, including bone demineralization, urinary calculi, cardiovascular instability, and reduced joint range of motion and muscular tone. (easystand.com)

Development of drugs to prevent TRAF3 degradation in immune and bone cells could be a novel therapeutic approach to prevent or reduce bone loss and the incidence of several common diseases associated with aging. (frontiersin.org)
However, the focus has moved from infancy to geriatrics, since low vitamin D status, bone diseases, and cardiovascular diseases are all prevalent in this age group [ 7 - 9 ]. (hindawi.com)
Corticosteroids used on a long-term corticosteroid induced avascular necrosis can cause avascular necrosis of bone and this has been seen in various diseases. (writingdesk.pw)
In addition in autoimmune diseases a correlation has been seen between glucocorticoid and bone death, which appears to be due to blood stasis and ischemia in the trabecular bone. (writingdesk.pw)

A and B, Radiologic images of rickets and pathologic fractures. (aappublications.org)
In the early 1920s, vitamin D was found to cure rickets, a bone disease that occurred endemically in infants and toddlers in many European countries and North America during the industrialization in the 19th and early 20th century [ 2 , 3 ]. (hindawi.com)

This normal process can be disturbed in a variety of pathologic processes, including localized or generalized inflammation, metabolic and endocrine disorders, primary and metastatic cancers, and during aging as a result of low-grade chronic inflammation. (frontiersin.org)
Reflects the metabolic reaction of bone to the disease process, with preferential uptake of the tracer at sites of active bone formation. (amazonaws.com)

Signs and symptoms can include diffuse body pains, muscle weakness, and fragility of the bones. (wikipedia.org)
Symptoms: Diffuse joint and bone pain (especially of spine, pelvis, and legs) Muscle weakness Difficulty walking, often with waddling gait Hypocalcemia (positive Chvostek sign) Compressed vertebrae and diminished stature Pelvic flattening Weak, soft bones Easy fracturing Bending of bones Osteomalacia in adults starts insidiously as aches and pains in the lumbar (lower back) region and thighs before spreading to the arms and ribs. (wikipedia.org)
Radiographic evidence of osteomyelitis lags behind symptoms and pathologic changes by 7 to 10 days. (smartypance.com)

[ 3 ] Other examples of entheses include the interface between cortical bone and the periosteum and that between vertebral bodies and the annulus fibrosus. (medscape.com)

Trabecular bone score (TBS) is a gray-level textural analysis that provides an indirect index of trabecular microarchitecture. (bvsalud.org)
Trabecular bone was normal and osteoblast and osteoclast activity was clearly evident. (lymphedemapeople.com)

About 500,000 of these procedures are conducted in the United States, and roughly 250,000 of the bone grafting procedures in the United States involve the spine. (justia.com)
C2 Solitary Bone Plasmacytoma Curettage and Vertebral Augmentation in an 83-Year-Old Female: Case Report and Review of Surgical Treatment Approaches in the Spine. (thefreelibrary.com)
Logically the greatest loss -demineralization- occurs in the weight bearing bones of the leg [Os Calcis] and spine. (novelguide.com)
In recent years, stereotactic body radiation therapy (SBRT) has become increasingly used for the management of non-spine bone metastases. (amegroups.com)
This article describes various changes on CT after SBRT to non-spine bone metastases in eight selected cases. (amegroups.com)
A retrospective review was conducted for patients treated with SBRT to non-spine bone metastases between November 2011 and April 2014 at Sunnybrook Health Sciences Centre. (amegroups.com)
Usually located around the knee in diaphysis or meta/diaphysis and does not occur in hands, feet, spine and flat bones. (radiologyassistant.nl)
A skeletal survey (includes lateral skull, cervical spine, anteroposterior (AP) and lateral thoracic and lumbar spine, an AP pelvis and chest radiograph) is used as the primary investigation for bone metastases. (amazonaws.com)

These metaplastic transformations result in new bone formation (periostitis), gradual ossification of syndesmoses (eg, the sacroiliac joints), and syndesmophyte formation along the outer fibers of the vertebral discs. (medscape.com)

Copper beaten" skull refers to the prominent convolutional markings seen in multiple bones of the skull. (cappskids.org)
Additional findings associated with a chronic increase in intracranial pressure include macrocrania, splitting of the sutures, skull demineralisation and erosion, or enlargement of the sella turcica. (cappskids.org)
If they become prominent and are evident throughout the skull rather than the posterior parts, they reflect a pathologic condition, the so called copper beaten skull. (cappskids.org)
They may normally disappear around puberty and should not be interpreted as abnormal unless definite signs of raised intracranial tension are present, such as suture spreading or serial changes are present, which include macrognathia, splitting of the sutures, skull demineralization and erosion or enlargement of the sella turcica. (cappskids.org)

MRI can provide information that is complementary to a skeletal survey and was recommended for use in patients with normal radiographic images and in all patients with an apparently solitary plasmacytoma of bone. (medscape.com)
Standard 99m Tc bone scintigraphy should play no role in the routine staging of myeloma, and sequential dual-energy radiographic absorptiometry (DXA) scans are not recommended, according to the authors. (medscape.com)
MRI can offer facts that is complementary to a skeletal survey and turned into endorsed for use in sufferers with normal radiographic photos and in all patients with a seemingly solitary plasmacytoma of bone. (canceroz.com)
popular 99mTc bone scintigraphy have to play no position inside the ordinary staging of myeloma, and sequential dual-electricity radiographic absorptiometry (DXA) scans are not advocated, consistent with the authors. (canceroz.com)

Few studies have examined the radiological changes in bone metastases after treatment with SBRT and there is no consensus about what constitutes radiologic response to therapy. (amegroups.com)

To the impact of this dynamicity it should be noted that a bone remodeling unit [a coupled phenomena of bone reabsorption and bone formation] is initiated and another finished about every ten seconds in a healthy adult. (novelguide.com)

The demineralized bone matrix will be used in promoting bone and cartilage repair and bone and cartilage growth and regeneration. (justia.com)
Radiologically the picture is variable depending on the stage of the disease but a wedge-shaped area of increased radio-opacity with the base adjacent to the articular cartilage and the apex pointing to head of the involved bone. (writingdesk.pw)
Examples of pathologic processes that commonly coexist include crystal deposition in osteoarthritis, synovitis in enthesopathies, and cartilage destruction in chronic synovitis. (medscape.com)
The inflamed synovium may infiltrate and erode intra-articular bone and cartilage. (medscape.com)
Within joints, the subchondral bone layer is a supporting structure for the overlying articular cartilage. (faoj.org)
Decorin is found in the extracellular matrix of a variety of connective tissues, including skin, tendon, bone, and cartilage. (livehopelupus.org)
weakest point of long bone is the cartilage growth plate, frequent site of damage during trauma. (studystack.com)

Classic X-ray triad of demineralization, periosteal reaction, and bone destruction. (smartypance.com)

Because the body's homeostatic response to these pathologic processes is very efficient, the serum HCO3- and blood pH are frequently maintained within the "normal" range. (nih.gov)
Even in patients with a normal serum HCO3- and blood pH, it is important to treat the acid load and prevent pathologic homeostatic responses. (nih.gov)

However, unlike the osteolyisis of inflamed joints, which reflects accelerated osteoclast activity, the systemic bone loss of arthritic mice is the result of arrested osteoblast function. (bloodjournal.org)
Unexpectedly, the osteoblast deficiency in bone formation did not affect the long-term repopulating potential of HSCs in these arthritic mice. (bloodjournal.org)

Osteoclast formation and activity are promoted by factors, including cytokines, hormones, growth factors, and free radicals, and require expression of macrophage-colony stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL) by accessory cells in the bone marrow, including osteoblastic and immune cells. (frontiersin.org)

May arise in any bone, but most commonly in femur and pelvis. (radiologyassistant.nl)

Patient may present with bone pain without known primary cancer and be found to have metastatic bone cancer. (amazonaws.com)

An autologous bone graft is derived from the recipient and is commonly taken from the iliac bone. (justia.com)
The middle cranial fossa was the most frequently fractured compartment, while the petrous bone was the most commonly fractured bone. (bvsalud.org)
In dermatological practice avascular necrosis of bone has been seen more commonly with SLE and also with psoriasis using long-term steroids. (writingdesk.pw)

Necrosis appears as a mottled area and the fibrous zone as a radiolucent band with demineralization of the uninvolved bone. (writingdesk.pw)
As a result of inflammation at these interfaces, the radially oriented collagen fibers undergo metaplasia, forming fibrous bone. (medscape.com)

It is possible that gravitational and muscular strains on the skeletal system cause friction between bone crystals which creates bioelectrical fields. (novelguide.com)

Furthermore, a technetium bone scan will show increased activity. (naturalheightgrowth.com)
Diagnostic tools bone scan using injected gas to move toward misalignment if the test if jaundice presents later vision of loss viagra than infant botulism. (bac.edu)
Here the MR, bone scan and the sonogram of the same patient with ABC. (radiologyassistant.nl)
A high-resolution CT scan postprocessed with a bone algorithm and viewed with wide windows at that age showed symmetrical, abnormal bandlike areas of lucency surrounding the cochlea. (ajnr.org)
The 3-phase bone scan is usually positive. (medscape.com)

Histologically, BMLs have been shown to be focal areas of demineralization, increased fibrosis, and vascular abnormalities. (faoj.org)

Secondary refers to bone loss caused by an underlying condition such as cancer, chronic obstructive pulmonary disease, certain drugs, chronic kidney disease, and endocrine disorders. (visualdx.com)
Conclusions: Our study shows that pubertal patients have a lower BMD than pre-pubertal ones as a consequence of the mild bone demineralization (BMD Z-score −1.15±0.97) secondary to GHD. (eurospe.org)

Anatomy9

Diseases19

Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes8

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science1

Health Care2

Bone mineral density of the proximal femur after unilateral cementless total hip replacement. (1/31)

Changes in urinary excretion of pyridinium cross-links during Spacelab-J. (2/31)

A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn's disease. (3/31)

Rapid hip bone loss in active Crohn's disease patients receiving short-term corticosteroid therapy. (4/31)

Muscle strength is a determinant of bone mineral content in the hemiparetic upper extremity: implications for stroke rehabilitation. (5/31)

Association between phosphate removal and markers of bone turnover in haemodialysis patients. (6/31)

Natural calcium isotopic composition of urine as a marker of bone mineral balance. (7/31)

Disease progression in Hutchinson-Gilford progeria syndrome: impact on growth and development. (8/31)

Bone Demineralization, Pathologic

Bone Demineralization Technique

Tooth Demineralization

Dental Enamel

Bone and Bones

Tooth Remineralization

Hardness Tests

Cariostatic Agents

Dental Caries Activity Tests

Microradiography

Fluorides, Topical

Root Caries

Dentin

Dental Caries

Dental Enamel Solubility

Bone Remodeling

Tooth Erosion

Encyclopedias as Topic

Tooth Calcification

Rickets

Hypophosphatasia

Hypophosphatemia

Sunlight

Weightlessness

Weightlessness Simulation

Hypergravity

Gravitation

Photoreceptor Cells, Vertebrate

Kinesis

Hypogravity

Injections, Intra-Articular

Triamcinolone Acetonide

Osteoarthritis

Osteoarthritis, Knee

Anti-Inflammatory Agents, Non-Steroidal

Osteoarthritis, Hip

Acetaminophen

Granuloma, Giant Cell

Mandibular Diseases

Fibrous Dysplasia, Monostotic

Paraneoplastic Syndromes

Phosphorus

Maxillary Diseases

Macrophages

Macrophage Activation

Bone Marrow Cells

Macrophages, Peritoneal

Monocytes

Cells, Cultured

Macrophage Colony-Stimulating Factor

Bone Matrix

Patents as Topic

Bone Density

Bone mineral density of the proximal femur after unilateral cementless total hip replacement. (1/31)

Changes in urinary excretion of pyridinium cross-links during Spacelab-J. (2/31)

A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn's disease. (3/31)

Rapid hip bone loss in active Crohn's disease patients receiving short-term corticosteroid therapy. (4/31)

Muscle strength is a determinant of bone mineral content in the hemiparetic upper extremity: implications for stroke rehabilitation. (5/31)

Association between phosphate removal and markers of bone turnover in haemodialysis patients. (6/31)

Natural calcium isotopic composition of urine as a marker of bone mineral balance. (7/31)

Disease progression in Hutchinson-Gilford progeria syndrome: impact on growth and development. (8/31)

Arterial stiffness and bone demineralization: The Baltimore longitudinal study of aging<...

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DME.00022 Functional Electrical Stimulation (FES); Threshold Electrical Stimulation (TES)

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