Bone Demineralization, Pathologic: Decrease, loss, or removal of the mineral constituents of bones. Temporary loss of bone mineral content is especially associated with space flight, weightlessness, and extended immobilization. OSTEOPOROSIS is permanent, includes reduction of total bone mass, and is associated with increased rate of fractures. CALCIFICATION, PHYSIOLOGIC is the process of bone remineralizing. (From Dorland, 27th ed; Stedman, 25th ed; Nicogossian, Space Physiology and Medicine, 2d ed, pp327-33)Bone Demineralization Technique: Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.Tooth Demineralization: A tooth's loss of minerals, such as calcium in hydroxyapatite from the tooth matrix, caused by acidic exposure. An example of the occurrence of demineralization is in the formation of dental caries.Dental Enamel: A hard thin translucent layer of calcified substance which envelops and protects the dentin of the crown of the tooth. It is the hardest substance in the body and is almost entirely composed of calcium salts. Under the microscope, it is composed of thin rods (enamel prisms) held together by cementing substance, and surrounded by an enamel sheath. (From Jablonski, Dictionary of Dentistry, 1992, p286)Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Tooth Remineralization: Therapeutic technique for replacement of minerals in partially decalcified teeth.Hardness Tests: A test to determine the relative hardness of a metal, mineral, or other material according to one of several scales, such as Brinell, Mohs, Rockwell, Vickers, or Shore. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Cariostatic Agents: Substances that inhibit or arrest DENTAL CARIES formation. (Boucher's Clinical Dental Terminology, 4th ed)Dental Caries Activity Tests: Diagnostic tests conducted in order to measure the increment of active DENTAL CARIES over a period of time.Microradiography: Production of a radiographic image of a small or very thin object on fine-grained photographic film under conditions which permit subsequent microscopic examination or enlargement of the radiograph at linear magnifications of up to several hundred and with a resolution approaching the resolving power of the photographic emulsion (about 1000 lines per millimeter).Fluorides, Topical: Fluorides, usually in pastes or gels, used for topical application to reduce the incidence of DENTAL CARIES.Root Caries: Dental caries involving the tooth root, cementum, or cervical area of the tooth.Dentin: The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root, which is harder and denser than bone but softer than enamel, and is thus readily abraded when left unprotected. (From Jablonski, Dictionary of Dentistry, 1992)Dental Caries: Localized destruction of the tooth surface initiated by decalcification of the enamel followed by enzymatic lysis of organic structures and leading to cavity formation. If left unchecked, the cavity may penetrate the enamel and dentin and reach the pulp.Dental Enamel Solubility: The susceptibility of the DENTAL ENAMEL to dissolution.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Tooth Erosion: Progressive loss of the hard substance of a tooth by chemical processes that do not involve bacterial action. (Jablonski, Dictionary of Dentistry, 1992, p296)Weightlessness: Condition in which no acceleration, whether due to gravity or any other force, can be detected by an observer within a system. It also means the absence of weight or the absence of the force of gravity acting on a body. Microgravity, gravitational force between 0 and 10 -6 g, is included here. (From NASA Thesaurus, 1988)Weightlessness Simulation: Condition under normal Earth gravity where the force of gravity itself is not actually altered but its influence or effect may be modified and studied. (From ASGSB Bull 1992;5(2):27)Hypergravity: Condition wherein the force of gravity is greater than or is increased above that on the surface of the earth. This is expressed as being greater than 1 g.Gravitation: Acceleration produced by the mutual attraction of two masses, and of magnitude inversely proportional to the square of the distance between the two centers of mass. It is also the force imparted by the earth, moon, or a planet to an object near its surface. (From NASA Thesaurus, 1988)Photoreceptor Cells, Vertebrate: Specialized PHOTOTRANSDUCTION neurons in the vertebrates, such as the RETINAL ROD CELLS and the RETINAL CONE CELLS. Non-visual photoreceptor neurons have been reported in the deep brain, the PINEAL GLAND and organs of the circadian system.Kinesis: Locomotor behavior not involving a steering reaction, but in which there may be a turning random in direction. It includes orthokinesis, the rate of movement and klinokinesis, the amount of turning, which are related to the intensity of stimulation.Hypogravity: Condition wherein the force of gravity is less than or is decreased below that on the surface of the earth. This is expressed as being between 0 and 1 g.Myostatin: A growth differentiation factor that is a potent inhibitor of SKELETAL MUSCLE growth. It may play a role in the regulation of MYOGENESIS and in muscle maintenance during adulthood.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Growth Differentiation Factor 15: A growth differentiation factor that is secreted in response to cell stress and in response to MACROPHAGE ACTIVATION. In addition growth differentiation factor 15 demonstrates a diverse array of biological properties including the induction of cartilage formation, the inhibition of hematopoietic progenitor proliferation, and the induction of neuronal migration.Growth Differentiation Factor 5: A growth differentiation factor that plays a role in early CHONDROGENESIS and joint formation.Catalogs, LibraryCatalogs as Topic: Ordered compilations of item descriptions and sufficient information to afford access to them.Follistatin: A broadly distributed protein that binds directly to ACTIVINS. It functions as an activin antagonist, inhibits FOLLICLE STIMULATING HORMONE secretion, regulates CELL DIFFERENTIATION, and plays an important role in embryogenesis. Follistatin is a single glycosylated polypeptide chain of approximately 37-kDa and is not a member of the inhibin family (INHIBINS). Follistatin also binds and neutralizes many members of the TRANSFORMING GROWTH FACTOR BETA family.Granuloma, Giant Cell: A non-neoplastic inflammatory lesion, usually of the jaw or gingiva, containing large, multinucleated cells. It includes reparative giant cell granuloma. Peripheral giant cell granuloma refers to the gingiva (giant cell epulis); central refers to the jaw.Rickets: Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.Mandibular DiseasesFibrous Dysplasia, Monostotic: FIBROUS DYSPLASIA OF BONE involving only one bone.Paraneoplastic Syndromes: In patients with neoplastic diseases a wide variety of clinical pictures which are indirect and usually remote effects produced by tumor cell metabolites or other products.Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.Maxillary DiseasesBone Matrix: Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Hydrogen: The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.Water Supply: Means or process of supplying water (as for a community) usually including reservoirs, tunnels, and pipelines and often the watershed from which the water is ultimately drawn. (Webster, 3d ed)Earth (Planet): Planet that is the third in order from the sun. It is one of the four inner or terrestrial planets of the SOLAR SYSTEM.Beginning of Human Life: The point at which religious ensoulment or PERSONHOOD is considered to begin.Fresh Water: Water containing no significant amounts of salts, such as water from RIVERS and LAKES.Arthropathy, Neurogenic: Chronic progressive degeneration of the stress-bearing portion of a joint, with bizarre hypertrophic changes at the periphery. It is probably a complication of a variety of neurologic disorders, particularly TABES DORSALIS, involving loss of sensation, which leads to relaxation of supporting structures and chronic instability of the joint. (Dorland, 27th ed)Podiatry: A specialty concerned with the diagnosis and treatment of foot disorders and injuries and anatomic defects of the foot.Diagnosis, Oral: Examination of the mouth and teeth toward the identification and diagnosis of intraoral disease or manifestation of non-oral conditions.Diabetic Foot: Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.Foot Diseases: Anatomical and functional disorders affecting the foot.Periodontics: A dental specialty concerned with the histology, physiology, and pathology of the tissues that support, attach, and surround the teeth, and of the treatment and prevention of disease affecting these tissues.Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)

Bone mineral density of the proximal femur after unilateral cementless total hip replacement. (1/31)

It was the aim of this study to examine bone mineral density changes in the non-operated contralateral femur of patients undergoing total hip replacement. Bone density in the contralateral femur of 45 patients with an average age of 54 years was measured with the aid of the DEXA technique at one week, 3 and 6 months after total hip replacement. Within the first 3 months there was an average reduction of bone density of 3.9% (3.0%-5.9%). After a further 3 months the average difference was 2.5%.  (+info)

Changes in urinary excretion of pyridinium cross-links during Spacelab-J. (2/31)

In SLJ-1 we proposed to study three major objectives. They were; 1. hormonal changes associated with fluid and electrolyte metabolism, 2. the effect of space flight on the circadian rhythms of endocrine and metabolic systems, 3. the changes in the indices of the bone and muscle metabolism during space flight. In this report, the changes in the bone metabolism during Spacelab-J will be presented with a special emphasis on urinary excretion of pyridinium cross-links. Timed urine samples from three Japanese payload specialists were obtained for 3 days from May 19 to 21, 1991 (one year before the launch = L-1 year). Immediately before the launch (L-3 to L-0), urine samples were obtained from a payload specialist who was on board the Space Shuttle Endeavor (PS). During the inflight period (flight from September 3 to 10 in 1992), urine samples from the PS were collected by using Urine Monitoring System (UMS). After the landing, they were obtained from the PS for three days (R+0-R+2). Various parameters related to bone metabolism such as hydroxyproline, pyridinium cross-links and calcium were determined. It was noted that excretion of hydroxyproline decreased during the preflight periods when compared with that in the control L-1 year period. The average excretory rate during control period was 846.2 +/- 198.7 milligrams/hour (mean +/- SD), while those in the preflight 474.6 +/- 171.1 milligrams/hour, suggesting the diminished collagen intake during the preflight period. Average excretion rate of pyridinium cross-links during the first 4 mission days (MD0-MD3) was similar to that of preflight and control L-1 year period. However, it was significantly increased during the last 4 mission days (MD4-MD7). It returned to the preflight level during postflight days (R+0-R+2). Increased urinary excretion of calcium during the last 4 mission days were also observed. These results suggest that increase in bone resorption could occur during relatively short stay in microgravity.  (+info)

A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn's disease. (3/31)

BACKGROUND: Osteoporosis is a common complication of Crohn's disease. AIM: To study the effect on the bone mineral density of a bisphosphonate (pamidronate) given intravenously, in combination with oral calcium and vitamin D supplements, compared with oral calcium and vitamin D supplements alone. METHODS: Seventy-four patients with Crohn's disease and low bone mineral density at the lumbar spine and/or hip were randomized to receive either a daily dose of 500 mg of calcium with 400 IU of vitamin D alone or in combination with four three-monthly infusions of 30 mg of intravenous pamidronate over the course of 12 months. The main outcome measure was the change in bone mineral density at the lumbar spine and hip, measured by dual X-ray absorptiometry, at baseline and 12 months. RESULTS: Both groups gained bone mineral density at the lumbar spine and hip after 12 months. There were significant (P < 0.05) changes in the pamidronate group, with gains of + 2.6%[95% confidence interval (CI), 1.4-3.0] at the spine and + 1.6% (95% CI, 0.6-2.5) at the hip, compared with gains of + 1.6% (95% CI, - 0.1-3.2) and + 0.9% (95% CI, - 0.4-2.1) at the spine and hip, respectively, in the group taking vitamin D and calcium supplements alone. CONCLUSIONS: In patients with Crohn's disease and low bone mineral density, intravenous pamidronate significantly increases the bone mineral density at the lumbar spine and hip.  (+info)

Rapid hip bone loss in active Crohn's disease patients receiving short-term corticosteroid therapy. (4/31)

BACKGROUND: Uncertainty over whether corticosteroids cause bone loss in patients with Crohn's disease may reflect their short, intermittent use. AIM: We investigated whether a 2-month course of prednisolone is associated with detectable bone loss. METHODS: Fifteen patients with active Crohn's disease and 19 controls with inactive Crohn's disease were recruited. Bone mineral density of the lumbar spine and hip was measured at baseline and 2 and 8 months. RESULTS: At 2 months, significant bone loss was found in patients with active disease (femoral neck -2.7%, P < 0.002; Ward's triangle -3.9%, P < 0.01). Although bone mineral density was still lower at 8 months, these differences were no longer significant (-1.3% and -3.4%, femoral neck and Ward's triangle, respectively). No significant change in hip bone mineral density was observed in controls. Previous corticosteroid use was not significantly associated with baseline bone mineral density, although significant independent associations were observed between weight, site of disease and lumbar spine bone mineral density, and between dietary calcium deficiency and femoral neck and Ward's triangle bone mineral density. CONCLUSION: Significant bone loss at the hip can be detected in patients receiving corticosteroid treatment for 2 months for active Crohn's disease ; however, it remains unclear whether this is because of disease activity or its treatment. This rapid bone loss may represent a risk factor for fracture and justify bone protective therapy.  (+info)

Muscle strength is a determinant of bone mineral content in the hemiparetic upper extremity: implications for stroke rehabilitation. (5/31)

Individuals with stroke have a high incidence of bone fractures and approximately 30% of these fractures occur in the upper extremity. The high risk of falls and the decline in bone and muscle health make the chronic stroke population particularly prone to upper extremity fractures. This was the first study to investigate the bone mineral content (BMC), bone mineral density (BMD), and soft tissue composition of the upper extremities and their relationship to stroke-related impairments in ambulatory individuals with chronic stroke (onset >1 year). Dual-energy X-ray absorptiometry (DXA) was used to acquire total body scans on 56 (22 women) community-dwelling individuals (>or=50 years of age) with chronic stroke. BMC (g) and BMD (g/cm2), lean mass (g), and fat mass (g) for each arm were derived from the total body scans. The paretic upper extremity was evaluated for muscle strength (hand-held dynamometry), impairment of motor function (Fugl-Meyer motor assessment), spasticity (Modified Ashworth Scale), and amount of use of the paretic arm in daily activities (Motor Activity Log). Results showed that the paretic arm had significantly lower BMC (13.8%, P<0.001), BMD (4.5%, P<0.001), and lean mass (9.0%, P<0.001) but higher fat mass (6.3%, P=0.028) than the non-paretic arm. Multiple regression analysis showed that lean mass in the paretic arm, height, and muscle strength were significant predictors (R2=0.810, P<0.001) of the paretic arm BMC. Height, muscle strength, and gender were significant predictors (R2=0.822, P<0.001) of lean mass in the paretic arm. These results highlight the potential of muscle strengthening to promote bone health of the paretic arm in individuals with chronic stroke.  (+info)

Association between phosphate removal and markers of bone turnover in haemodialysis patients. (6/31)

BACKGROUND: As the main mineral reservoir, bone acts as a calcium (Ca) and phosphate buffering system. Accordingly, phosphate removal by haemodialysis (HD) might be theoretically influenced by bone turnover, as well as by the interaction of regulatory molecules, such as PTH and osteoprotegerin (OPG). The present study investigated the relationship between these variables and phosphate removal by HD. METHODS: Blood samples for serum Ca, phosphate, bicarbonate, intact PTH, PTH (1-84), bone alkaline phosphatase, tartrate-resistant acid phosphatase 5b, OPG and receptor activator of nuclear factor-kappaB ligand (RANKL) were obtained in 28 HD patients. Phosphate removal was measured by a continuous collection of the dialysate. RESULTS: Pre-dialysis serum phosphate concentration is the critical factor in determining dialytic phosphate removal. However, multiple regression analysis reveals that phosphate removal is better explained by a combination of factors than by phosphate concentration alone. In this model, the PTH/OPG ratio is an additional positive factor, whereas age and vitamin D treatment are negative factors. Patients with pre-HD bicarbonate higher than 20 mEq/l had higher serum phosphate and, accordingly, higher phosphate removal; of interest, these individuals also have significant differences in RANKL/OPG. Mean (SD) OPG levels were significantly higher than that in the healthy population (16.2 (12.5) pmol/l; these values correlated with age (r = 0.4, P<0.04). Mean serum RANKL (1.03 (1.02) pmol/l) was within the range of normal individuals. CONCLUSIONS: Dialytic phosphate removal has a crucial, direct relationship with pre-HD plasma phosphate levels. However, the phenomenon of phosphate removal is more precisely explained using a more complex relationship, defined by the interaction between serum phosphate, PTH/OPG, age and vitamin D administration. Serum RANKL levels are first reported in HD patients, and are not different from the normal population.  (+info)

Natural calcium isotopic composition of urine as a marker of bone mineral balance. (7/31)

BACKGROUND: We investigated whether changes in the natural isotopic composition of calcium in human urine track changes in net bone mineral balance, as predicted by a model of calcium isotopic behavior in vertebrates. If so, isotopic analysis of natural urine or blood calcium could be used to monitor short-term changes in bone mineral balance that cannot be detected with other techniques. METHODS: Calcium isotopic compositions are expressed as delta(44)Ca, or the difference in parts per thousand between the (44)Ca/(40)Ca of a sample and the (44)Ca/(40)Ca of a standard reference material. delta(44)Ca was measured in urine samples from 10 persons who participated in a study of the effectiveness of countermeasures to bone loss in spaceflight, in which 17 weeks of bed rest was used to induce bone loss. Study participants were assigned to 1 of 3 treatment groups: controls received no treatment, one treatment group received alendronate, and another group performed resistive exercise. Measurements were made on urine samples collected before, at 2 or 3 points during, and after bed rest. RESULTS: Urine delta(44)Ca values during bed rest were lower in controls than in individuals treated with alendronate (P <0.05, ANOVA) or exercise (P <0.05), and lower than the control group baseline (P <0.05, t-test). Results were consistent with the model and with biochemical and bone mineral density data. CONCLUSION: Results confirm the predicted relationship between bone mineral balance and calcium isotopes, suggesting that calcium isotopic analysis of urine might be refined into a clinical and research tool.  (+info)

Disease progression in Hutchinson-Gilford progeria syndrome: impact on growth and development. (8/31)

OBJECTIVES: Hutchinson-Gilford progeria syndrome is a rare and uniformly fatal segmental "premature aging" disease that affects a variety of organ systems. We sought to more clearly define the bone and weight abnormalities in patients with progeria as potential outcome parameters for prospective clinical trials. PATIENTS AND METHODS: We collected and analyzed longitudinal medical information, both retrospectively and prospectively, from a total of 41 children with Hutchinson-Gilford progeria syndrome spanning 14 countries, from the Progeria Research Foundation Medical and Research Database at the Brown University Center for Gerontology. RESULTS: In addition to a number of previously well-defined phenotypic findings in children with progeria, this study identified abnormalities in the eruption of secondary incisors lingually and palatally in the mandible and maxilla, respectively. Although bony structures appeared normal in early infancy, clavicular resorption, coxa valga, avascular necrosis of the femoral head, modeling abnormalities of long bones with slender diaphyses, flared metaphyses, and overgrown epiphyses developed. Long bones showed normal cortical thickness centrally and progressive focal demineralization peripherally. The most striking finding identified in the retrospective data set of 35 children was an average weight increase of only 0.44 kg/year, beginning at approximately 24 months of age and persisting through life, with remarkable intrapatient linearity. This rate is >2 SD below normal weight gain for any corresponding age and sharply contrasts with the parabolic growth pattern for normal age- and gender-matched children. This finding was also confirmed prospectively. CONCLUSIONS: Our analysis shows evidence of a newly identified abnormal growth pattern for children with Hutchinson-Gilford progeria syndrome. The skeletal and dental findings are suggestive of a developmental dysplasia rather than a classical aging process. The presence of decreased and linear weight gain, maintained in all of the patients after the age of 2 years, provides the ideal parameter on which altered disease status can be assessed in clinical trials.  (+info)

*List of MeSH codes (C05)

... bone demineralization, pathologic MeSH C05.116.198.247.400 --- decalcification, pathologic MeSH C05.116.198.371 --- ... File "2006 MeSH Trees".) MeSH C05.116.070.265 --- bone cysts, aneurysmal MeSH C05.116.099.052 --- acro-osteolysis MeSH C05.116. ... alveolar bone loss MeSH C05.116.264.579 --- osteolysis MeSH C05.116.264.579.052 --- acro-osteolysis MeSH C05.116.264.579. ... fibrous dysplasia of bone MeSH C05.116.099.708.375.199 --- cherubism MeSH C05.116.099.708.375.372 --- fibrous dysplasia, ...

*Osteomalacia

As a result of demineralization, the bones become less rigid. Physical signs include deformities like triradiate pelvis and ... Pathologic fractures due to weight bearing may develop. Most of the time, the only alleged symptom is chronic fatigue, while ... The impairment of bone metabolism causes inadequate bone mineralization. Osteomalacia in children is known as rickets, and ... Osteomalacia is a generalized bone condition in which there is inadequate mineralization of the bone. Many of the effects of ...

*Human tooth

The alveolar bone is the bone of the jaw which forms the alveolus around teeth. Like any other bone in the human body, alveolar ... This process, known as "demineralisation", leads to tooth destruction. Saliva gradually neutralises the acids which cause the ... other than dental caries is considered a normal physiologic process but may become severe enough to become a pathologic ... Periodontal ligaments connect the alveolar bone to the cementum. Alveolar bone surrounds the roots of teeth to provide support ...
TY - JOUR. T1 - Arterial stiffness and bone demineralization. T2 - The Baltimore longitudinal study of aging. AU - Giallauria, Francesco. AU - Ling, Shari M.. AU - Schreiber, Catherine. AU - Maggio, Marcello. AU - Shetty, Veena. AU - Muller, Denis. AU - Vigorito, Carlo. AU - Ferrucci, Luigi. AU - Najjar, Samer S.. PY - 2011/9/1. Y1 - 2011/9/1. N2 - BACKGROUND: Arterial stiffening is one of the hallmarks of vascular aging, and is an important risk factor for cardiovascular morbidity and mortality. Aging is also associated with bone demineralization. Accumulating evidence indicate that arterial stiffness and bone demineralization might share common pathways. The aims of this study were to evaluate whether the association between arterial stiffness and bone demineralization is independent of age, and to explore putative mechanisms that may mediate their relationship. METHODS: A cross-sectional analysis was performed using data from 321 men (68 ± 12 years) and 312 women (65 ± 13 years) of the ...
Advanced Triple Boron with Calcium is a well-balanced formula for bone health. It contains three bioavailable forms of the trace mineral boron, which supports the prevention of calcium loss and bone demineralization, plus calcium to promote bone strength. Advanced Triple Boron with Calcium features eight other essential vitamins and minerals including magnesium and vitamin D to support bone mineral density.
Without regular use, the muscles weaken and slowly deteriorate, a process called atrophy. Disuse also causes the bones to degenerate and weaken. In microgravity, the musculoskeletal system is not used as intensively as it is on Earth, which causes a reduction of bone and muscle strength and size, particularly in the bones and muscles that are used to support the body against gravity. Muscle atrophy results in a loss of lean body mass, a decrease of muscle mass in gravity-bearing muscles, and decreased muscle strength. Bone demineralization results in a loss of calcium and bone density. To study the changes in bones and muscles in space, measurements of protein and calcium metabolism are made. Exposure to microgravity produces a negative calcium and nitrogen balance in the musculoskeletal system. Non-invasive imaging methods, like Magnetic Resonance Imaging (MRI), can be used to study the structural changes in bone and muscle after exposure to microgravity. The long-duration Mir missions allowed ...
Symptoms of short-term vitamin D toxicity are due to high calcium levels (also known as hypercalcemia) and include confusion, increased urination, increased thirst, loss of appetite, vomiting, and muscle weakness. Acute hypercalcemia may intensify tendencies for heart arrhythmias and seizures and may increase the effects of certain heart drugs. Long-term toxicity may cause kidney failure, increase in calcium deposits in the blood and soft tissue, bone demineralization and pain. Patients with conditions such as liver disease or chronic kidney failure may be at increased risk for developing vitamin D toxicity ...
Results Thirty four women and ten men fulfilled the inclusion criteria. The mean age was 53±13 [18-76] years. The onset of symptoms was mono-articular in 54.5%, oligo-articular in 11.3% and polyarticular in 34.2% of cases. The mean duration of the disease was 11.2±7.6 [2-24] months. Radiographs showed epiphyseal bone demineralization in 12 cases. Ultrasound showed at least one synovitis in 39 patients, 17 of which associated with Doppler hyperhemia. More than 5 joints were involved in 32 patients and bone erosions were detected in 19 cases. High resolution ultrasound allowed confirmation of early RA in 43.1% of cases since it showed bone erosions in 19 patients with inflammatory rheumatism, elsewhere ultrasound has helped the diagnosis of early inflammatory rheumatism since it showed polysynovitis in 14 of 24 patients showing a mono-articular clinical involvement.. ...
One of the main drawbacks of traditional dentures is that they can become loose or fit poorly. This is because your gum and bone tissues will continue to change over time meaning that your dentures original fit wont fit as well compared to when you first received them. Dentures also have a tendency of slipping or falling out, which can make speaking and chewing difficult.. To address these problems, Dynasty Tower Dental offers implant supported dentures to our patients. Implant supported dentures stay in place by a small number of dental implants that are embedded into your jawbone. Besides anchoring the dentures into place, the implants help to prevent bone demineralization and maintain your jaws overall structure. As a result, implant supported dentures are more stable, comfortable, and aesthetically pleasing than traditional dentures.. ...
Once a diagnosis is made, optimally, the veterinarian and farrier will work together to come up with a shoeing regimen/prescription. For example, the veterinarian may prescribe nonsteroidal anti-inflammatory agents (NSAIDS), and, while consulting with the farrier for his/her input, they will arrive at a shoeing regimen that will vary according to the needs of the animal. Severe or chronic sole bruising must be minimized. I always recommend an aluminum shoe since aluminum absorbs more concussion than steel. It is sole concussion that initiates the inflammatory process responsible for bone demineralization and periosteal proliferation. These horses also benefit from the use of sole-toughening agents such as a combination of iodine and formaldehyde in a 1:1 solution concentration. Commercial products like Durasole can be employed by the farrier and client. In an effort to minimize the forces of weight bearing on the sole, I have seen egg bar shoes prescribed with a sole trimmed to achieve a deep ...
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D-D The Aquarium Solution ROWA PHOS PHOSPHATE REMOVAL MATERIAL 250 ML (6/CASE) Rowa Phos Phosphate Removal Material ROWAPHOS 250ML 6/CASE You can now feed your fish and not your algae! ROWA phos is the professional way to control nuisance algae in freshwater marine aquariums, ponds and lakes.It adsorbs phosphate, silicate and heavy metals from the water column without releasing any back into the tank when fully loaded. It can be left indefinitely in the aquarium with no ill effects and only changed when exhausted. ROWA phos is highly recommended for use from day 1 when starting up an aquarium as it removes phosphates and silicates from the substrate or live rock and reduces the likelihood of a severe algae bloom during the cycling period. Use of ROWA phos in an aquarium allows much higher fish stocking with healthy feeding levels without causing excessive nuisance algae s. Using a patented manufacturing process Rowa has produced a unique iron hydroxide based compound which is unlike any other iron based
D-D The Aquarium Solution ROWA PHOS PHOSPHATE REMOVAL MATERIAL 1000 ML = 1 LITER (3/CASE) Rowa Phos Phosphate Removal Material ROWAPHOS 1000ML (1 LITER) 3/CA You can now feed your fish and not your algae! ROWA phos is the professional way to control nuisance algae in freshwater marine aquariums, ponds and lakes.It adsorbs phosphate, silicate and heavy metals from the water column without releasing any back into the tank when fully loaded. It can be left indefinitely in the aquarium with no ill effects and only changed when exhausted. ROWA phos is highly recommended for use from day 1 when starting up an aquarium as it removes phosphates and silicates from the substrate or live rock and reduces the likelihood of a severe algae bloom during the cycling period. Use of ROWA phos in an aquarium allows much higher fish stocking with healthy feeding levels without causing excessive nuisance algae s. Using a patented manufacturing process Rowa has produced a unique iron hydroxide based compound which is unlike
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Author: Sealy, Judith et al.; Genre: Journal Article; Published in Print: 2014; Title: Comparison of two methods of extracting bone collagen for stable carbon and nitrogen isotope analysis: Comparing whole bone demineralization with gelatinization and ultrafiltration
6) Promotes good eyesight. Rich in vitamin A as well as beta-carotene, chives ensure the health of our eyesight. Lutein and zeaxanthin, antioxidants with vitamin A activity, protect the macula lutea area and the retina from harmful free radicals from light and are said to contribute to lowering macular degeneration risks (loss of central vision).. 7) Increases calcium absorption in bones. Chives are an incredible source of vitamin K, a nutrient known to increase calcium absorption in bones. By preventing hormonal imbalances leading to bone demineralization, vitamin K preserves bone integrity and bone health. Moreover, a healthy intake also prevents arterial calcification and its aftermath, atherosclerosis.. 8) Reduces inflammation levels. Rich in vitamins C and K, two potent natural anti-inflammatory vitamins, chives are efficient at reducing inflammation levels levels in the body. According to research, high inflammation levels play a big part in the onset of chronic diseases such as diabetes, ...
FES is designed to stimulate muscles and thus improve the function of the extremities. FES has primarily been investigated in individuals with neurologic impairment, most prominently following SCI, stroke or multiple sclerosis. The stimulation is directed at improving function by utilizing devices intended to restore ambulation in the lower extremity or dexterity and function in the upper extremity; or devices to indirectly improve function, such as exercise devices adapted to FES, which are designed to prevent or treat muscle disuse atrophy. The majority of these devices use surface electrodes, but intramuscular (IM) electrodes have also been used. Standard therapy in individuals with neurologic impairment includes active and passive physiotherapy and the use of various braces and orthoses. Therefore, studies were reviewed that investigate the outcomes of FES compared to these standard therapies. FES Devices to Prevent Muscle Atrophy and Bone Demineralization A variety of devices use electrical ...
AquaConSoil 2015: 13th International UFZ-Deltares Conference on Sustainable Use and Management of Soil, Sediment and Water Resources - Bella Centret, Copenhagen, ...
Generally, gastric mucosal calcinosis (GMC) is only rarely encountered in routine biopsies. They have been associated with a wide spectrum of clinical conditions. The underlying mechanism by which a given cell or group of cells accumulate calcium is unclear. It has been suggested that calcium enters the cell by passive diffusion attributable to the concentration gradient across the gastric cell membrane, and that accumulation occurs when the ability to extrude these salts is exceeded. Gastric mucosal calcinosis (GMC) may be secondary to hypercalcemia, hyperphosphatemia, atrophic gastritis, hypervitaminosis A, chronic kidney disease, tumor lysis syndrome, organ transplantation, gastric neoplasia, or may be associated with use of citrate-containing blood products, aluminum-containing antacids, sucralfate or bismuth [1-6]. GMC may rarely cause symptoms such as epigastric pain or dyspepsia [7,8]. The clinical relevance of GMC remains to be seen. In theory, however, accelerated bone demineralization ...
Complex regional pain syndrome (CRPS) is a disorder of the extremities that is characterized by spontaneous unexplained disproportionate pain, hyperalgesia, swelling, limited range of motion, vasomotor instability, skin changes, and patchy bone demineralization.The incidence of CRPS was estimated to be 5.46 per 100,000 person years at risk in Olmsted County, Minnesota (US), with a prevalence of 20.57 per 100,000, while its incidence in the general population of the Netherlands was estimated to be much higher, at 26.2 per 100,000 person-years. The adverse effects were not serious and lasted just a few days. The beneficial effects of other bisphosphonates have been already documented in several placebo-controlled trials; however, there are no reports on the use of zoledronic acid to reduce pain in CRPS patients ...
TY - JOUR. T1 - Effective phosphate removal from synthesized wastewater using copper-chitosan bead. T2 - Batch and fixed-bed column studies. AU - An, Byungryul. AU - Jung, Ka Young. AU - Lee, Sang-Hyup. AU - Lee, Seunghak. AU - Choi, Jae Woo. PY - 2014. Y1 - 2014. N2 - To remove phosphate from solution, a new class of sorbent based on chitosan bead (CB) was prepared using copper ion (Cu(II)) with/without a traditional crosslinking agent (glutaraldehyde [GLA]); these materials are referred to as CB-G-Cu and CB-Cu, respectively. Copper ions play a key role in the CB synthesis; these species crosslink each polymer chain, and during phosphate removal, they are the active functional group. Overall, 2.5% (w/w) of chitosan is necessary to maintain the physical properties of the bead. In the FTIR spectra, adding GLA decreased the intensity of the amino group in chitosan, lowering the amount of copper in the CB. The maximum phosphate uptake (Q) for CB-Cu was 53.6 mg g-1 when calculated with the Langmuir ...
Blueprint Genetics Hereditary Breast and Gynecological Cancer Panel Is ideal for patients with a clinical suspicion of an inherited susceptibility to breast and gynecological cancer. This panel is designed to detect
The present invention relates to a method for the demineralization of water using a combination of a monodisperse cation filter operated as a lift bed and a monodisperse anion filter operated in the cocurrent flow procedure, and also devices which comprise such a lift bed in combination with at least one cocurrent flow filter and if appropriate a trickling degasser and/or a mixed-bed filter.
For any mission, NASA has to make numerous decisions that balance mission necessity against health and safety risks for the crew, technological feasibility, and financial costs. The possible health risks -- such as vision impairments, bone demineralization, radiation exposure, and impact on behavior -- vary from mission to mission. Long duration and exploration spaceflights, including extended stays on the International Space Station and trips to Mars, will likely expose crews to increased risks. As part of its risk management process to protect the health and safety of astronauts, NASA has adopted standards to provide a healthy and safe environment before, during, and after all flights. The committee stressed that NASAs policies to initiate and revise health standards should reflect the most relevant and up-to-date evidence, but recommended that NASA explicitly indicate how these policies are consistent with the ethics principles described in the report ...
Hierarchically macroporous-mesoporous SBA-15 phosphate adsorbent was synthesized via a dual-templating approach, followed by diamino-functionalization and Fe(III) impregnation. The resulting Fe(III)-coordinated diamino-functionalized macroporous-mesoporous adsorbent possessed well-defined and interconnecting macroporous and mesoporous networks. Its maximum adsorption was 12.7 mg/g, which was 86.8% greater than that of Fe(III)-coordinated amino-functionalized mesoporous SBA-15. In the kinetic study of macroporous-mesoporous adsorbent, 92.5% of the final adsorption capacity reached in the first 1 min; and the adsorption followed the pseudo-second-order equation well, suggesting the presence of chemisorption. The pH ranging from 3.0 to 6.0 favored the high phosphate adsorption of hierarchically porous adsorbent; however, the coexistence of other anions, especially F-, retarded the adsorption.. ...
Scientists from a wide variety of disciplines were brought together in this group in the hope that useful exchanges of ideas would in the long-term help in our understanding of the problem of...
This is a randomized, open label intra-patient crossover study of Vigil, the checkpoint inhibitor Atezolizumab and the combination of the two agents, in patients with epithelial ovarian cancer, or other gynecological cancers (i.e., cervical, uterine). Eligible patients will be randomized to receive two cycles of Vigil alone or two cycles of Atezolizumab alone, followed by combination treatment with the two agents. Patients may continue on single agent Atezolizumab until disease progression, only if pre-approved by Sponsor.. This study is intended as a companion study to protocol CL-PTL-119, A Randomized, Double Blind, Placebo Controlled Phase 2 trial of Vigil Engineered Autologous Tumor Cell Immunotherapy in Subjects with Stage IIIb-IV Ovarian Cancer in Clinical Complete Response following Surgery and Primary Chemotherapy, otherwise known as the VITAL study. Patients who have tumor harvested at surgery and Vigil successfully manufactured, but then are ineligible for randomization onto the VITAL ...
Gynecological cancers are a group of cancers that affect the female reproductive system. St. Lukes provides personalized care for female pelvic malignancies.
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The frequency of CAM use we found is in line with international data from CCCs in the USA. To our knowledge, this is the first study publishing data on the frequency of potential interactions. Thus, an initiative to protect women from the dangers of uncontrolled CAM use is urgently needed. In the di …
Discover New Jerseys comprehensive Gynecological Cancers center. Learn more about our multi-disciplinary team and advanced treatment options.
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Cavity formation / Tooth demineralization explained. | What role do bacteria, dental plaque, sugar and acid play? | How to use this info to prevent decay.
St. Lukes Cancer Center offers a highly coordinated and personalized team approach to bladder cancer care. Meet your team of St. Lukes cancer specialists.
Medical Xpress is a web-based medical and health news service that features the most comprehensive coverage in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more.
Medical Xpress is a web-based medical and health news service that features the most comprehensive coverage in the fields of neuroscience, cardiology, cancer, HIV/AIDS, psychology, psychiatry, dentistry, genetics, diseases and conditions, medications and more.
Three samples of terra rossa were shown to be efficient adsorbents of phosphate [P(V)] from wastewater and removed 29.9-32.6% of P(V). The total iron content in terra rossa was the key factor which determined the P(V) removal from wastewater. The original samples of terra rossa were effective support materials for the immobilization of metabolically active P(V)-accumulating bacteria Acinetobacter junii (0.56-2.47×1010 CFU g-1). The removal of oxalate-extractable iron from original sample of terra rossa increased the number of immobilized bacteria to 1.34×1011 CFU g-1, which is the largest number of immobilized bacteria reported in the literature so far. In reactors containing the A. junii and terra rossa P(V) was removed from wastewater by simultaneous adsorption onto terra rossa and accumulation inside bacterial cells, resulting in 40.5-62.5% of P(V) removal. Terra rossa is a promising substrate for biological P(V) removal from wastewater, acting both as adsorbent of P(V) and carrier of ...
The content on this site is for informational purposes only. It is not a substitute for professional medical advice. Do not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. Use of this online service is subject to the disclaimer and the terms and conditions.. Copyright 2000-2016 © Cancer Survivors Network. ...
The content on this site is for informational purposes only. It is not a substitute for professional medical advice. Do not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. Use of this online service is subject to the disclaimer and the terms and conditions.. Copyright 2000-2016 © Cancer Survivors Network. ...
Dr. Michael Rodriguez and Dr. Michael Method at Michiana Hematology Oncology have provided Michiana women with care for specifically gynecological cancers for more than five years. Â?Basically,
Neonatal primary hyperparathyroidism is a life threatening disorder that is associated with severe hypercalcaemia, hypotonia, bone demineralization, fractures and respiratory distress. Treatment consists of total parathyroidectomy and without this affected infants will usually die by the age of three months. We report a patient with neonatal primary hyperparathyroidism who survived without fractures or parathyroidectomy to an age of nine months, and in whom the hypercalcaemia became masked by vitamin D deficiency. At surgery, four-gland hyperplasia was demonstrated and total parathyroidectomy followed by oral calcitriol treatment has restored well-being and normocalcaemia. An absence of skeletal complications, a survival beyond three months of age without parathyroidectomy and the masking of the hypercalcaemia by vitamin D deficiency represents a unique combination of metabolic abnormalities in a patient with neonatal primary hyperparathyroidism.
This is Part 2 of an in vitro study investigating two techniques for recording and quantifying demineralization surrounding orthodontic brackets. In Part 1 the repeatability of computerized image analysis from digitally converted photographic slides and quantitative light‐induced fluorescence (QLF) was explored. In Part 2 of the investigation the validity of each technique was examined.. Thirty halved human molars, shaped to look like incisors and with an orthodontic bracket bonded to the buccal surface were used. A small area of each of the four edges of the bracket was variously exposed to a demineralizing gel for 0, 3, 7, or 14 days. Images of the teeth were taken and analysed using the two techniques. Repeat images and analysis were carried out blind. The sensitivity, specificity, positive, and negative predictive values were calculated.. A negative result confirmed that there was no demineralization present in the majority of cases. A positive result was less reliable particularly for the ...
Anonymous]. 2012. Ovarian cancer screening--what women want.. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. 22 Suppl 1:S21-3. ...
We performed a retrospective 2-year study of patients diagnosed with a gynecological cancer and whose treatment regimen contained carboplatin (AUC dose = 5 or 6) and paclitaxel (dose = 175 mg/m2) every 3 weeks (CP scheme). We recorded all severe hematological events (thrombocytopenia, neutropenia, and/or anemia grade III/IV) according to the CTCAE v4.03, as well as treatment modifications and the need for granulocyte colony-stimulating factors (G-CSF) and/or erythropoietin (EPO) or packed red blood cells (PRBC). Patients with a body mass index (BMI) ≥27 kg/m2 were considered as overweight (OW) and those with a BMI ,27 kg/m2 were considered as normal weight (NW ...
20150210 BiAqua B.V. - Mrs. Sandie Chauveau - "Biofouling of membrane systems by phosphate limitation" The start-up BiAqua developed a novel approach (invented by TUD) of combating bio-fouling by selective phosphate removal from the feed water, which stops the growth of micro-organisms. Phosphate is adsorbed to below 1 μg/l on a bio-degradable adsorbens, containing iron with good affinity to phosphate.. The adsorbens in a normal sand-filter or IX housing is operated as such and can be regenerated multiple times with caustic. Pilot on drinking water and secondary wastewater treatment effluent proved effective and stable, resulting in constant low pressure drop over RO modules that otherwise exhibited severe bio-fouling.. Applications in surface water, horticulture, cooling towers are developed with partners. Outlook for 2015 is demo scale. www.biaqua.nl. ...
At Mount Sinai Chelsea, we specialize in diagnosing and treating women who have breast or gynecological cancer; our expert staff of specialists will design a personalized treatment plan that works for you. W
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In most viral infections, protection through existing vaccines is linked to the presence of vaccine-induced neutralizing antibodies (NAbs). However, more than 30 years after the identification of AIDS, the design of an immunogen able to induce antibodies that would neutralize the highly diverse HIV-1 variants remains one of the most puzzling challenges of the human microbiology. The role of antibodies in protection against HIV-1 can be studied in a natural situation that is the mother-to-child transmission (MTCT) context. Indeed, at least at the end of pregnancy, maternal antibodies of the IgG class are passively transferred to the fetus protecting the neonate from new infections during the first weeks or months of life. During the last few years, strong data, presented in this review, have suggested that some NAbs might confer protection toward neonatal HIV-1 infection. In cases of transmission, it has been shown that the viral population that is transmitted from the mother to the infant is usually
Differences between the prescribed dose of radiation in intensity modulated radiation therapy (IMRT) and the dose thats actually delivered may make comparison studies in gynecological cancers difficult to interpret. These findings were reported in the Journal of the National Cancer Institute.. Radiation therapy is often used in the treatment of various forms of cancer. Radiation therapy uses beams of radiation to slow or stop cancer cell growth, which shrinks or eliminates the tumor.. Intensity modulated radiation therapy is an advanced radiation technique that uses computers to control the devices that deliver precise radiation doses to malignant tumors or specific areas of the tumor. Because the surrounding tissues are minimally affected with IMRT, higher, more-effective radiation doses may be delivered to the tumor, with fewer side effects. Currently, IMRT is approved for the treatment of cancers of the prostate, head and neck, breast, thyroid, and lung, as well as for gynecological cancers, ...
Administration of recombinant human erythropoietin in patients with gynecological cancer before radical surgery. - V Dousias, T Stefos, I Navrozoglou, I Staikos, A Ditto, E Paraskevaidis
... , causes. Progeria disease is a genetic disorder characterized by rapid aging in children

Tumor-Induced Rickets in a Child With a Central Giant Cell Granuloma: A Case Report | Case Reports | PediatricsTumor-Induced Rickets in a Child With a Central Giant Cell Granuloma: A Case Report | Case Reports | Pediatrics

... demonstrate progressive diffuse bone demineralization, widening of the growth plates, metaphyseal cupping and fraying, bowing ... Multiple pathologic fractures made the patient wheelchair-bound, and weakness of the thoracic cage was reflected in a reduction ... Bone mass, bone reabsorption parameters, and FGF23 levels normalized. Because the samples had to be sent away, we measured ... Treatment of bone tumours by radiofrequency thermal ablation. Curr Rev Musculoskelet Med. 2009;2(1):43-50pmid:19468917. ...
more infohttp://pediatrics.aappublications.org/content/135/6/e1518

Biomedical results of the Skylab Program.Biomedical results of the Skylab Program.

Bone Demineralization, Pathologic / physiopathology, prevention & control. Cardiovascular Deconditioning. Erythrocyte Volume. ... 16313354 - Microgravity: the immune response and bone.. 7484174 - Effects of endurance training on left ventricular performance ...
more infohttp://www.biomedsearch.com/nih/Biomedical-results-Skylab-Program/11977284.html

The Effects of Prolonged Weightlessness and Reduced Gravity Environments on Human Survival - PubMedThe Effects of Prolonged Weightlessness and Reduced Gravity Environments on Human Survival - PubMed

Bone Demineralization, Pathologic / physiopathology *. Actions. * Search in PubMed * Search in MeSH * Add to Search ... Prevention of Bone Loss and Muscle Atrophy During Manned Space Flight TS Keller et al. Microgravity Q 2 (2), 89-102. Apr 1992. ... the single factor that most limits human survivability in non-Earth environments is the phenomenon of bone demineralization and ... Exposure of astronauts to microgravity leads to the loss of calcium from weightbearing bones. Prolonged exposure, e.g., during ...
more infohttps://pubmed.ncbi.nlm.nih.gov/11539500/

Validation Results With Nejm Articles - DNAHelix.orgValidation Results With Nejm Articles - DNAHelix.org

Bone Demineralization, Pathologic. 2818. 18784102 NHERF1 mutations and responsiveness of renal parathyroid hormone.. ... 18445777 Multiple genetic loci for bone mineral density and fractures.. BTF3L1 (690). Fractures, Bone. 11309. 18445777 Multiple ... 18445777 Multiple genetic loci for bone mineral density and fractures.. BTF3L1 (690). Bone Diseases, Metabolic. 10894. 18445777 ... 18445777 Multiple genetic loci for bone mineral density and fractures.. ZBTB40 (9923). Bone Diseases, Metabolic. 10889. ...
more infohttp://dnahelix.wikidot.com/validation-results-with-nejm-articles

Cinacalcet for Treatment of Chronic Kidney Disease-Mineral and Bone Disorder: A Meta-Analysis of Randomized Controlled Trials.Cinacalcet for Treatment of Chronic Kidney Disease-Mineral and Bone Disorder: A Meta-Analysis of Randomized Controlled Trials.

Bone Demineralization, Pathologic. Decrease, loss, or removal of the mineral constituents of bones. Temporary loss of bone ... Chronic Kidney Disease-mineral And Bone Disorder. Decalcification of bone or abnormal bone development due to chronic KIDNEY ... Chronic Kidney Disease and Bone - Correlation Between 18F-PET-TT Imaging and Histomorphometry of Bone in CKD Patients ... Bone and mineral disease is a key problem in patients with kidney disease. The available clinical parameters are non-specific, ...
more infohttps://www.bioportfolio.com/resources/pmarticle/1984598/Cinacalcet-for-Treatment-of-Chronic-Kidney-Disease-Mineral-and-Bone-Disorder-A.html

List of MeSH codes (C05) - WikipediaList of MeSH codes (C05) - Wikipedia

... bone demineralization, pathologic MeSH C05.116.198.247.400 --- decalcification, pathologic MeSH C05.116.198.371 --- ... File "2006 MeSH Trees".) MeSH C05.116.070.265 --- bone cysts, aneurysmal MeSH C05.116.099.052 --- acro-osteolysis MeSH C05.116. ... alveolar bone loss MeSH C05.116.264.579 --- osteolysis MeSH C05.116.264.579.052 --- acro-osteolysis MeSH C05.116.264.579. ... fibrous dysplasia of bone MeSH C05.116.099.708.375.199 --- cherubism MeSH C05.116.099.708.375.372 --- fibrous dysplasia, ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(C05)

Indications for Bone-Modifying Agents in Hematology-Oncology | Hematology-Oncology Therapy, 2e | AccessHemOnc | McGraw-Hill...Indications for Bone-Modifying Agents in Hematology-Oncology | Hematology-Oncology Therapy, 2e | AccessHemOnc | McGraw-Hill...

To prevent treatment-related bone demineralization, osteolysis, and pathologic fractures. *. To treat osteolytic lesions, ... "Indications for Bone-Modifying Agents in Hematology-Oncology." Hematology-Oncology Therapy, 2e Boyiadzis MM, Frame JN, Kohler ... Shalabi R, Frame J.N. Shalabi, Reem Abozena, and James N. Frame.Indications for Bone-Modifying Agents in Hematology-Oncology. ... The American Society of Bone and Mineral Research Task Force has defined osteonecrosis of the jaw (ONJ) as the presence of ...
more infohttp://hemonc.mhmedical.com/content.aspx?bookid=1611§ionid=126669160

Comparative Effect of rhPTH(1-84) on Bone Mineral Density and Trabecular Bone Score in Hypoparathyroidism and Postmenopausal...Comparative Effect of rhPTH(1-84) on Bone Mineral Density and Trabecular Bone Score in Hypoparathyroidism and Postmenopausal...

... and trabecular bone score (TBS) in hypoparathyroidism over a 2-yea... ... Bone Demineralization, Pathologic. Decrease, loss, or removal of the mineral constituents of bones. Temporary loss of bone ... Bone Demineralization Technique. Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as ... Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE ...
more infohttps://www.bioportfolio.com/resources/pmarticle/2120755/Comparative-Effect-of-rhPTH-1-84-on-Bone-Mineral-Density-and-Trabecular.html

GDF-8/Myostatin Proteins: Novus BiologicalsGDF-8/Myostatin Proteins: Novus Biologicals

Bone Demineralization, Pathologic (1). *. Brain Diseases (1). *. Brain Neoplasms (3). *. Brain Pathology (2) ...
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EnglishEnglish

Pathologic fractures and bone demineralization in the presence of normal serum concentrations of calcium, phosphorus, and ... involvement of bone, gonads, muscle, skin, and connective tissue, as well as stereotypic behavior, also can occur. Additional ...
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Top Drugstore: Loss of vision viagra original suppliers!Top Drugstore: Loss of vision viagra original suppliers!

Fever, bone pain, osteitis fibrosa cystica diffuse demineralization, pathologic fractures, diffuse bone demineralization, renal ... Diagnostic tools bone scan using injected gas to move toward misalignment if the test if jaundice presents later vision of loss ... Bone marrow transplant. Postinfectious glomerulonephritis presents about days of exposure.. viagra quebec online Skip to common ...
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Congenital Syphilis Article - StatPearlsCongenital Syphilis Article - StatPearls

Long bone radiographs that may show findings of pathologic fractures, metaphyseal serration, localized demineralization, and ... The Journal of bone and joint surgery. British volume. 1989 Nov [PubMed PMID: 2584243]. ... is released straight into the bloodstream of the fetus causing spirochetemia with spread to most organs including the bones, ...
more infohttps://www.statpearls.com/kb/viewarticle/19869/

Intravenous Regional Phenoxybenzamine in the Treatment of Reflex Sympathetic Dystrophy   | Anesthesiology | ASA PublicationsIntravenous Regional Phenoxybenzamine in the Treatment of Reflex Sympathetic Dystrophy | Anesthesiology | ASA Publications

... and characteristic demineralization of the bone. [3] The pathologic mechanism in RSD is not known, and various treatment ...
more infohttps://anesthesiology.pubs.asahq.org/article.aspx?articleid=1948348

Radiological changes on CT after stereotactic body radiation therapy to non-spine bone metastases: a descriptive series  -...Radiological changes on CT after stereotactic body radiation therapy to non-spine bone metastases: a descriptive series -...

... demineralization of sclerotic bone metastases, pathologic fracture, size progression and response in different lesions, as well ... Radiological changes on CT after stereotactic body radiation therapy to non-spine bone metastases: a descriptive series. Posted ... Conclusions: We reviewed the radiological images of eight selected cases after SBRT to nonspine bone metastases and a number of ... Quality of life in responders after palliative radiation therapy for painful bone metastases using EORTC QLQ-C30 and EORTC QLQ- ...
more infohttp://apm.amegroups.com/post/view/radiological-changes-on-ct-after-stereotactic-body-radiation-therapy-to-non-spine-bone-metastases-a-descriptive-series

Osteomalacia - WikipediaOsteomalacia - Wikipedia

As a result of demineralization, the bones become less rigid. Physical signs include deformities like triradiate pelvis[10] and ... Pathologic fractures due to weight bearing may develop. Most of the time, the only alleged symptom is chronic fatigue, while ... decreased bone mass Osteopetrosis unaffected unaffected elevated unaffected[citation needed] thick dense bones also known as ... Pagets disease of bone unaffected unaffected variable (depending on stage of disease) unaffected abnormal bone architecture ...
more infohttps://en.wikipedia.org/wiki/Osteomalacia

US Patent for Process for demineralization of bone matrix with preservation of natural growth factors Patent (Patent #  9,114...US Patent for Process for demineralization of bone matrix with preservation of natural growth factors Patent (Patent # 9,114...

... thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process. ... on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second ... The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as ... produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone ...
more infohttps://patents.justia.com/patent/9114191

Complex Regional Pain Syndrome: Systemic Complications (Page 3)Complex Regional Pain Syndrome: Systemic Complications (Page 3)

Frequent sites of pathologic fracture are the fifth metatarsal of the foot and the distal ulna. Further demonstrations of bone ... and periosteal demineralization; and bone resorption.75 These changes occur from activated osteoclasts, possibly due to the ... Capsaicinsensitive sensory neurons contribute to the maintenance of trabecular bone integrity. J Bone Miner Res. 2005;20(2):257 ... 75 Bone formation and maintenance are dependent on a small fiber innervation, which may be deficient in CRPS.3,77-79 Pathologic ...
more infohttps://www.practicalpainmanagement.com/pain/complex-regional-pain-syndrome-systemic-complications?page=0,2

Acute and chronic osteomyelitis (ReelDx) | PANCE and PANRE Content BlueprintAcute and chronic osteomyelitis (ReelDx) | PANCE and PANRE Content Blueprint

Classic X-ray triad of demineralization, periosteal reaction, and bone destruction. *Radiographic evidence of osteomyelitis ... it is relatively nonspecific and makes differentiating osteomyelitis from other pathologic conditions difficult. ... An acute or chronic infection and inflammation of the bone and bone marrow; can occur as a result of hematogenous seeding, a ... A probe can be passed into the ulcer; however, it is not readily apparent if bone can be contacted with the probe. Laboratory ...
more infohttps://smartypance.com/lessons/infectious-diseases/acute-chronic-osteomyelitis-reeldx518/

Bone demineralisation in a large cohort of Wilson disease patients.  - PubMed - NCBIBone demineralisation in a large cohort of Wilson disease patients. - PubMed - NCBI

Bone Demineralization, Pathologic/diagnostic imaging. *Bone Demineralization, Pathologic/epidemiology. *Bone Demineralization, ... Bone demineralisation in a large cohort of Wilson disease patients.. Weiss KH1, Van de Moortele M, Gotthardt DN, Pfeiffenberger ... We compared the bone mineral density (BMD) of adult Wilson disease (WD) patients (n = 148), with an age- and gender-matched ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=huge&id=104533

Hyperparathyroidism - Management of Patients With Parathyroid DisordersHyperparathyroidism - Management of Patients With Parathyroid Disorders

Musculoskeletal symptoms accompanying hyperparathyroidism may result from demineralization of the bones or bone tumors composed ... The patient may develop skeletal pain and tender-ness, especially of the back and joints; pain on weight bearing; pathologic ... and renal and bone changes. Bone changes may be detected on x-ray or bone scans in advanced disease. The double antibody ... In patients with significant bone disease or bone changes, a more prolonged period of hypocalcemia should be anticipated. The ...
more infohttps://www.brainkart.com/article/Hyperparathyroidism---Management-of-Patients-With-Parathyroid-Disorders_32183/

Craniofacial Abnormalities in Hutchinson-Gilford Progeria Syndrome | American Journal of NeuroradiologyCraniofacial Abnormalities in Hutchinson-Gilford Progeria Syndrome | American Journal of Neuroradiology

However, we noted mottling of the flat bones of the skull and postulate that this finding may represent bony demineralization, ... This finding can be seen in genetic disorders, as an anatomic variant,26 and secondary to pathologic states such as chronic ... In the developing calvarium, appositional bone growth increases bone thickness.23 Disturbed appositional bone growth in HGPS ... Bone growth at the calvarial sutures and fontanels occurs via intramembranous bone deposition at suture edges.22 Widened ...
more infohttp://www.ajnr.org/node/12049.full.print

A Study On Tumor Induced Osteomalacia - Natural Height GrowthA Study On Tumor Induced Osteomalacia - Natural Height Growth

Due to demineralization bones become less rigid. Physical signs include deformities like triradiate pelvis[6] and lordosis. The ... Pathologic fractures due to weight bearing may develop. Most of the time, the only alleged symptom is chronic fatigue, while ... Osteomalacia is a generalized bone condition in which there is inadequate mineralization of the bone. Many of the effects of ... Osteomalacia is the softening of the bones caused by defective bone mineralization secondary to inadequate amounts of available ...
more infohttp://www.naturalheightgrowth.com/2012/09/12/a-study-on-tumor-induced-osteomalacia/

alkaline water pain |  ionized alkaline  water with molecular hydrogen & BEST WATER IONIZERSalkaline water pain | ionized alkaline water with molecular hydrogen & BEST WATER IONIZERS

However, these homeostatic responses engender pathologic consequences such as nephrolithiasis, bone demineralization, muscle ... Alkaline mineral water lowers bone resorption even in calcium sufficiency: alkaline mineral water and bone metabolism. Bone. ... Bone Loss prevention with alkaline water. The bone minerals that are wasted in the urine may not have complete compensation ... Chronic metabolic acidosis alters bone cell function; there is an increase in osteoclastic bone resorption and a decrease in ...
more infohttps://water-ionizers.info/en/tag/alkaline-water-pain/

A Closer Look At Beaming The Columns In The Charcot Diabetic Foot | Podiatry TodayA Closer Look At Beaming The Columns In The Charcot Diabetic Foot | Podiatry Today

Additionally, a reduction in bone stiffness with a concomitant increase in bone density may suggest a pathologic proliferation ... This leads to weakening of bone strength without evidence of demineralization.11 ... Osteoclasts are among the three main cells present in bone and they resorb bone tissue.3 The elevated bone resorptive process ... Its primary locations are skin, tendon, bone and dentin.6 Collagen crosslinking within bone is known to affect bone stiffness ...
more infohttps://www.podiatrytoday.com/closer-look-beaming-columns-charcot-diabetic-foot?page=3
  • The differential diagnosis of osteogenesis imperfecta tarda affecting the temporal bone includes otosclerosis, Paget disease, otosyphilis, and Camurati-Engelmann disease. (ajnr.org)
  • We describe serial CT and MR imaging findings of the temporal bone in a patient with genetically proved Van der Hoeve-de Kleyn syndrome and discuss the key distinguishing features in the radiologic and clinical differential diagnosis. (ajnr.org)
  • Osteoclast formation and activity are promoted by factors, including cytokines, hormones, growth factors, and free radicals, and require expression of macrophage-colony stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL) by accessory cells in the bone marrow, including osteoblastic and immune cells. (frontiersin.org)
  • The bone marrow is completely normal. (radiologyassistant.nl)
  • Hypoparathyroidism is a rare disorder that is associated with abnormal bone properties. (bioportfolio.com)
  • The disease is characterized by abnormal bone fragility, osteopenia, blue color of the sclerae, defective dentition, presenile hearing loss, and ligamentous laxity. (ajnr.org)
  • Here a bone lesion in a patient with known NHL. (radiologyassistant.nl)
  • In a patient younger than 40 years a sclerotic lesion is usually an incidental benign finding like an ossified NOF, bone island, osteoid osteoma or infection. (radiologyassistant.nl)
  • The syndrome of RSD includes manifestations such as severe burning pain, hyperpathia, allodynia, hyperhidrosis, edema, vasomotor instability, and characteristic demineralization of the bone. (asahq.org)
  • We reviewed the radiological images of eight selected cases after SBRT to nonspine bone metastases and a number of characteristic findings were highlighted. (amegroups.com)
  • In recent years, stereotactic body radiation therapy (SBRT) has become increasingly used for the management of non-spine bone metastases. (amegroups.com)
  • This article describes various changes on CT after SBRT to non-spine bone metastases in eight selected cases. (amegroups.com)
  • A retrospective review was conducted for patients treated with SBRT to non-spine bone metastases between November 2011 and April 2014 at Sunnybrook Health Sciences Centre. (amegroups.com)
  • About 500,000 of these procedures are conducted in the United States, and roughly 250,000 of the bone grafting procedures in the United States involve the spine. (justia.com)
  • Other locations include the proximal humerus or spine, but many other bones are possible. (radiologyassistant.nl)
  • Usually located around the knee in diaphysis or meta/diaphysis and does not occur in hands, feet, spine and flat bones. (radiologyassistant.nl)
  • This normal process can be disturbed in a variety of pathologic processes, including localized or generalized inflammation, metabolic and endocrine disorders, primary and metastatic cancers, and during aging as a result of low-grade chronic inflammation. (frontiersin.org)
  • Secondary refers to bone loss caused by an underlying condition such as cancer, chronic obstructive pulmonary disease, certain drugs, chronic kidney disease, and endocrine disorders. (visualdx.com)
  • Few studies have examined the radiological changes in bone metastases after treatment with SBRT and there is no consensus about what constitutes radiologic response to therapy. (amegroups.com)
  • Is serum sclerostin a marker of atherosclerosis in patients with chronic kidney disease-mineral and bone disorder? (bioportfolio.com)
  • The clinical management of chronic kidney disease-mineral bone disorder (CKD-MBD) remains extremely challenging, partially due to difficulties in defining high-risk phenotypes based on serum biomarker. (bioportfolio.com)
  • Serum bone formation markers were high: osteocalcin 52 ng/mL (reference range 4-12 ng/mL), alkaline phosphatase 23 μg/L (reference range 7.5-17 μg/L), and bone-specific alkaline phosphatase 36.5 μg/L (reference range 7.5-17 g/L). Tubular reabsorption of phosphate measured by ratio of the renal tubular maximum reabsorption rate of phosphate to the glomerular filtration rate (TmP/GFR) was normal initially ( Fig 3 ). (aappublications.org)
  • The Effects of Long-term Administration of rhPTH(1-84) in Hypoparathyroidism by Bone Histomorphometry. (bioportfolio.com)
  • Diagnostic tools bone scan using injected gas to move toward misalignment if the test if jaundice presents later vision of loss viagra than infant botulism. (bac.edu)
  • Furthermore, a technetium bone scan will show increased activity. (naturalheightgrowth.com)
  • Here the MR, bone scan and the sonogram of the same patient with ABC. (radiologyassistant.nl)
  • A high-resolution CT scan postprocessed with a bone algorithm and viewed with wide windows at that age showed symmetrical, abnormal bandlike areas of lucency surrounding the cochlea. (ajnr.org)
  • can occur as a result of hematogenous seeding, a contiguous spread of infection, or direct inoculation into intact bone (trauma or surgery). (smartypance.com)
  • Autologous bone graft, sometimes referred to as an autograft (i.e., the patient's own bone), may be harvested to supply the needed bone to repair the defect. (justia.com)
  • The imaging findings of the temporal bone on CT in patients with Van der Hoeve-De Kleyn syndrome have been only rarely described ( 4 , 6 - 10 ), and the MR imaging findings have been sporadically reported by only three authors ( 10 - 12 ). (ajnr.org)
  • Temporary loss of bone mineral content is especially associated with space flight, weightlessness, and extended immobilization. (bioportfolio.com)
  • Autologous bone, however, is limited in supply, is generally painful to the patient upon harvesting, and may lead to significant donor site morbidity (i.e., may require additional surgical incisions in the patient, may lead to surgical complications, blood loss and may cause additional patient discomfort, and may ultimately increase patient recovery time). (justia.com)
  • The demineralized bone matrix will be used in promoting bone and cartilage repair and bone and cartilage growth and regeneration. (justia.com)
  • When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process. (justia.com)
  • The pain is symmetrical, non-radiating and accompanied by sensitivity in the involved bones. (wikipedia.org)