The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
The presence of free HEMOGLOBIN in the URINE, indicating hemolysis of ERYTHROCYTES within the vascular system. After saturating the hemoglobin-binding proteins (HAPTOGLOBINS), free hemoglobin begins to appear in the urine.
RED BLOOD CELL sensitivity to change in OSMOTIC PRESSURE. When exposed to a hypotonic concentration of sodium in a solution, red cells take in more water, swell until the capacity of the cell membrane is exceeded, and burst.
A syndrome of HEMOLYSIS, elevated liver ENZYMES, and low blood platelets count (THROMBOCYTOPENIA). HELLP syndrome is observed in pregnant women with PRE-ECLAMPSIA or ECLAMPSIA who also exhibit LIVER damage and abnormalities in BLOOD COAGULATION.
A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.
The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.
Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.
Proteins from BACTERIA and FUNGI that are soluble enough to be secreted to target ERYTHROCYTES and insert into the membrane to form beta-barrel pores. Biosynthesis may be regulated by HEMOLYSIN FACTORS.
A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
Plasma glycoproteins that form a stable complex with hemoglobin to aid the recycling of heme iron. They are encoded in man by a gene on the short arm of chromosome 16.
A test to detect non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells.
Diazo derivatives of aniline, used as a reagent for sugars, ketones, and aldehydes. (Dorland, 28th ed)
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
A method to identify and enumerate cells that are synthesizing ANTIBODIES against ANTIGENS or HAPTENS conjugated to sheep RED BLOOD CELLS. The sheep red blood cells surrounding cells secreting antibody are lysed by added COMPLEMENT producing a clear zone of HEMOLYSIS. (From Illustrated Dictionary of Immunology, 3rd ed)
Agglutination of ERYTHROCYTES by a virus.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
Hemolytic anemia due to the ingestion of fava beans or after inhalation of pollen from the Vicia fava plant by persons with glucose-6-phosphate dehydrogenase deficient erythrocytes.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).
The number of RETICULOCYTES per unit volume of BLOOD. The values are expressed as a percentage of the ERYTHROCYTE COUNT or in the form of an index ("corrected reticulocyte index"), which attempts to account for the number of circulating erythrocytes.
Abnormal intracellular inclusions, composed of denatured hemoglobin, found on the membrane of red blood cells. They are seen in thalassemias, enzymopathies, hemoglobinopathies, and after splenectomy.
A bile pigment that is a degradation product of HEME.
The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).
A 150-kDa serum glycoprotein composed of three subunits with each encoded by a different gene (C8A; C8B; and C8G). This heterotrimer contains a disulfide-linked C8alpha-C8gamma heterodimer and a noncovalently associated C8beta chain. C8 is the next component to bind the C5-7 complex forming C5b-8 that binds COMPLEMENT C9 and acts as a catalyst in the polymerization of C9.
Immunizing agent containing IMMUNOGLOBULIN G anti-Rho(D) used for preventing Rh immunization in Rh-negative individuals exposed to Rh-positive red blood cells.
The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.
Yellow discoloration of the SKIN; MUCOUS MEMBRANE; and SCLERA in the NEWBORN. It is a sign of NEONATAL HYPERBILIRUBINEMIA. Most cases are transient self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) occurring in the first week of life, but some can be a sign of pathological disorders, particularly LIVER DISEASES.
The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.
A nutritional condition produced by a deficiency of VITAMIN E in the diet, characterized by posterior column and spinocerebellar tract abnormalities, areflexia, ophthalmoplegia, and disturbances of gait, proprioception, and vibration. In premature infants vitamin E deficiency is associated with hemolytic anemia, thrombocytosis, edema, intraventricular hemorrhage, and increasing risk of retrolental fibroplasia and bronchopulmonary dysplasia. An apparent inborn error of vitamin E metabolism, named familial isolated vitamin E deficiency, has recently been identified. (Cecil Textbook of Medicine, 19th ed, p1181)
A group of familial congenital hemolytic anemias characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. The erythrocytes have increased osmotic fragility and are abnormally permeable to sodium ions.
Exotoxins produced by certain strains of streptococci, particularly those of group A (STREPTOCOCCUS PYOGENES), that cause HEMOLYSIS.
A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.
Oxygen-carrying RED BLOOD CELLS in mammalian blood that are abnormal in structure or function.
The effects, both local and systemic, caused by the bites of SPIDERS.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
A condition characterized by an abnormal increase of BILIRUBIN in the blood, which may result in JAUNDICE. Bilirubin, a breakdown product of HEME, is normally excreted in the BILE or further catabolized before excretion in the urine.
C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.
Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)
Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature.
Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.
A species of gram-negative, aerobic bacteria that is the etiologic agent of epidemic typhus fever acquired through contact with lice (TYPHUS, EPIDEMIC LOUSE-BORNE) as well as Brill's disease.
Stable chromium atoms that have the same atomic number as the element chromium, but differ in atomic weight. Cr-50, 53, and 54 are stable chromium isotopes.
A 105-kDa serum glycoprotein with significant homology to the other late complement components, C7-C9. It is a polypeptide chain cross-linked by 32 disulfide bonds. C6 is the next complement component to bind to the membrane-bound COMPLEMENT C5B in the assembly of MEMBRANE ATTACK COMPLEX. It is encoded by gene C6.
The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
A spider of the genus Loxosceles, found in the midwestern and other parts of the United States, which carries a hemolytic venom that produces local necrosis or ulceration.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Plasmids controlling the synthesis of hemolysin by bacteria.
An examination of chemicals in the blood.
An autosomal recessive glycogen storage disease in which there is deficient expression of 6-phosphofructose 1-kinase in muscle (PHOSPHOFRUCTOKINASE-1, MUSCLE TYPE) resulting in abnormal deposition of glycogen in muscle tissue. These patients have severe congenital muscular dystrophy and are exercise intolerant.
A 93-kDa serum glycoprotein encoded by C7 gene. It is a polypeptide chain with 28 disulfide bridges. In the formation of MEMBRANE ATTACK COMPLEX; C7 is the next component to bind the C5b-6 complex forming a trimolecular complex C5b-7 which is lipophilic, resembles an integral membrane protein, and serves as an anchor for the late complement components, C8 and C9.
The type (and only) species of RUBIVIRUS causing acute infection in humans, primarily children and young adults. Humans are the only natural host. A live, attenuated vaccine is available for prophylaxis.
Solutions that have a lesser osmotic pressure than a reference solution such as blood, plasma, or interstitial fluid.
The most common etiologic agent of GAS GANGRENE. It is differentiable into several distinct types based on the distribution of twelve different toxins.
... mechanisms of hemolysis, red blood cell destruction; and iron overload, a serious chronic condition in which the body absorbs ...
Other protective clothing, such as full body protection, are useful as well. Among the agents useful for decontamination of MD ... hemolysis can also occur. MD is not persistent, meaning that it will dissipate after a short time. It is, however, still quite ...
... a process known as hemolysis. Anti-K does not bind complement, therefore hemolysis is extravascular. Individuals without K ... Autoimmune hemolytic anemia (AIHA) occurs when the body produces an antibody against a blood group antigen on its own red blood ... Weiner CP, Widness JA (February 1996). "Decreased fetal erythropoiesis and hemolysis in Kell hemolytic anemia". American ... must be transfused with blood from donors who are also K0 to prevent hemolysis. ...
Hemolysis may require transfusion and could lead to kidney failure. Deaths have been reported from suspected brown recluse ... Serious systemic effects known as visceral loxoscelism may occur before this time, as the venom spreads throughout the body. ... Rarely more severe symptoms occur including hemolysis, thrombocytopenia, and disseminated intravascular coagulation. ... and that give the appearance of two body parts that are joined by a small connector. The family Sicariidae includes three ...
It can form inappropriately as a result of hemolysis or vascular injury. Several proteins in human blood bind to hemin, such as ... Hemin is endogenously produced in the human body, for example during the turnover of old red blood cells. ...
Although the healthy body stores three to five years' worth of B12 in the liver, the usually undetected autoimmune activity in ... Other than anemia, hematological symptoms may include cytopenias, intramedullary hemolysis, and pseudothrombotic ... Vitamin B12 cannot be produced by the human body, and must be obtained from the diet. When foods containing B12 are eaten, the ... Following its release, most B12 is absorbed by the body in the small bowel (ileum) after binding to a protein known as ...
Hemolysis is the general term for excessive breakdown of red blood cells. It can have several causes and can result in ... RBCs take up oxygen in the lungs, or in fish the gills, and release it into tissues while squeezing through the body's ... The cells develop in the bone marrow and circulate for about 100-120 days in the body before their components are recycled by ... During plasma donation, the red blood cells are pumped back into the body right away and only the plasma is collected. Some ...
In very rare cases, bites can even cause hemolysis-the bursting of red blood cells.[31] ... When alarmed it may lower its body, withdraw the forward two legs straight rearward into a defensive position, withdraw the ... When both types of loxoscelism do result, systemic effects may occur before necrosis, as the venom spreads throughout the body ... Rarely, such bites can result in hemolysis, thrombocytopenia, disseminated intravascular coagulation, organ damage, and even ...
... surface in the presence of relatively lower temperatures compared to core body temperature. Yet, the place where the hemolysis ... Hemolysis induced by cold agglutinin disease taking place outside the vessels while which of Donath-Landsteiner antibodies is ... Normally, no cryoglobulins should be found in the body. Cryoglobulins more than often do not interact with red blood cells, ... At least 90% of cases having cryoglobulins in body, hepatitis C is to blame, reflecting the importance of preclusion of ...
Dosage of osmotic agent administration is referred to as grams per person's body mass (g/ kg). Urea with σ=.59 was introduced ... However, it can cause rebound effects and side effects such as intravascular hemolysis and phlebitis. When Urea is administered ... However, it could cause diuresis, renal failure, hyperkalemia and hemolysis. If mannitol is administered, the dosage used is ... but it has a likelihood of exhibiting rebound effects and causing side effects such as hemolysis, hemoglobinuria, renal failure ...
The purpose is to prevent blood flow to an area of the body, which can effectively shrink a tumor or block an aneurysm. The ... However it does cause hemolysis and kidney failure in large doses. sotradecol - This agent is used for superficial lower ... These are also very good for AVM deep within the body. The disadvantage is that they are not easily targeted in the vessel. ... Embolization is used to treat a wide variety of conditions affecting different organs of the human body. The treatment is used ...
In extravascular hemolysis, red blood cells are phagocytized by macrophages in the spleen and liver. Abnormal value of ... There are other causes besides what happens within the body in the blood cells. Other factors that can cause an excess amount ... In intravascular hemolysis, hemoglobin is released and binds with haptoglobin. This causes haptoglobin levels to decrease. Once ... This is an effect of intravascular hemolysis, in which hemoglobin separates from red blood cells, a form of anemia. ...
Repetitive impacts to the body may cause mechanical trauma and bursting (hemolysis) of red blood cells. This has been ... a clue to footstrike hemolysis. Runner's anemia as a benefit versus runner's hemolysis as a detriment". The American Journal of ... The impact forces from running can lead to red blood cell hemolysis and accelerate red blood cell production. This can shift ... March hemoglobinuria, occurs when hemoglobin is seen in the urine after repetitive impacts on the body, particularly affecting ...
If a high reticulocyte count is found, it is usually linked to hemolysis, but a Coombs test may be performed in this case to ... Because there are more red blood cells needed in the body at that moment, they are released prematurely, leading to ... This type of anemia is usually caused by underproduction of blood cells as well as hemolysis. Anemia can be caused by either ... either from the bone marrow itself or as a consequence of metastasis from another part of the body.[citation needed] Normocytic ...
Phototherapy may cause hemolysis by rupturing red blood cell cell membranes in this way. In addition, end-products of lipid ... Other anti-oxidants made within the body include the enzymes superoxide dismutase, catalase, and peroxidase. The end products ... as a healthy human body has protective mechanisms in place against such hazards. Certain diagnostic tests are available for the ... as well as in body fluids, including human serum and plasma samples. Autoxidation Rancidification Huang, Han-Yao; Appel, ...
Smith, A. U. "Prevention of Haemolysis during Freezing and Thawing of Red Blood Cells." Lancet 2 (1950):910-911. Smith, A. U.; ... "Resuscitation of Hamsters after Supercooling or Partial Crystallization at Body Temperatures Below 0°C". Nature. 173 (4415): ...
Streptococcus pneumoniae produce green (alpha) hemolysis, or partial reduction of red blood cell hemoglobin. Risk factors for ... orbital foreign body, carotid cavernous fistula) Malformation (congenital, vascular) Immediate treatment is very important, and ... Recent upper respiratory illness Sinus infection Younger age Retained foreign bodies within the orbit Trauma Immunosuppression ...
A shortage of red blood cells to carry oxygen throughout the body leads to extreme tiredness (fatigue), pale skin (pallor), and ... Since the anemia results from the premature breakdown of red blood cells (hemolysis), it is known as hemolytic anemia. ...
... preventing a longer and more dangerous effect of hemolysis within the body. ... Visualization of hemolysis (UK: haemolysis) of red blood cells in agar plates facilitates the categorization of Streptococcus. ... As the bone marrow cannot make erythrocytes fast enough to meet the body's needs, oxygen does not arrive to body tissues ... Despite causing some severe pathologies, many cases of hemolysis do not suppose a health hazard. But the fact that hemolysins ( ...
In other cases like Parischnogaster striatula, the venom is applied all over their body as an antimicrobial protection. The ... venom from Agelaia pallipes has inhibitory effects on processes like chemotaxis and hemolysis which can lead to organ failure. ... Many caterpillars have defensive venom glands associated with specialized bristles on the body, known as urticating hairs, ...
... or hemolysis) to detect antibodies that could cause transfusion reactions.:722-5 Blood group antibodies occur in two major ... 477 although anti-RhD usually occurs as IgG in the body.:161 Antibodies that are predominantly IgG, such as those directed ... The tubes are incubated at body temperature for a defined period of time, then centrifuged and examined for agglutination or ... hemolysis; first immediately following the incubation period, and then after washing and addition of anti-human globulin ...
Too much hemoglobin C can reduce the number and size of red blood cells in the body, which is the cause of mild anemia. Some ... Continued hemolysis may produce pigmented gallstones, an unusual type of gallstone composed of the dark-colored contents of red ...
Contains 90% limonene.[citation needed] Henna oil, used in body art. Known to be dangerous to people with certain enzyme ... Raupp P, Hassan JA, Varughese M, Kristiansson B (November 2001). "Henna causes life threatening haemolysis in glucose-6- ... June 2007). "Allergies associated with body piercing and tattoos: a report of the Allergy Vigilance Network". European Annals ...
Body art quality henna is often more finely sifted than henna powders for hair. In Ancient Egypt, Ahmose-Henuttamehu (17th ... Raupp, P; Hassan, JA; Varughese, M; Kristiansson, B (1 November 2001). "Henna causes life threatening haemolysis in glucose-6- ... Anyone who has an itching and blistering reaction to a black body stain should go to a doctor, and report that they have had an ... Henna imported into the U.S. that appears to be for use as body art is subject to seizure, but prosecution is rare. Commercial ...
When a baby has jaundice or hyperbilirubinemia, this can indicate that the baby's body is producing excess bilirubin or that ... hemolysis). Bilirubin is then metabolized in the liver, recycled, and excreted in the bowel movements. ... In 1956, Sister Ward, a nurse at Rochford General Hospital in Essex, England, discovered that a jaundiced infant's body had ... this is normal because that is the way bilirubin is removed from the body. As bilirubin levels return to normal and ...
Haemolysis occurs either through haemoglobin defects, such as formation of Heinz bodies, or cell membrance defects, especially ... This haemolysis is usually accompanied by neurological effects such as vertigo, lethargy and convulsions, usually caused by ...
Different national bodies and medical associations have established varying standards for the use of immunoglobulin therapy. ... Some immunoglobulin solutions also contain isohemagglutinins, which in rare circumstances can cause hemolysis by the ... Immunoglobulin therapy also interferes with the ability of the body to produce a normal immune response to an attenuated live ... the body's defence system) works abnormally and destroys the protective covering over the nerves. It is indicated for ...
... they grab onto the skin and then breakthrough into inside the victim's body. This causes hemolysis within the body while they ... He would learn that he was originally Josefumi Kujo, a friend of the Kira Family whose body was altered by the power of the ... Ozon Baby can also create illusions of itself, and getting close to it will cause the body to cave in on itself from the ... The fruit takes effect with Kira's body parts being swapped with Josefumi's to turn him into Josuke, with what remained of ...
... body fat redistribution (BFR) syndrome - body fluids - bone marrow - bone marrow suppression - booster - branched DNA assay - ... hemolysis - hemophilia - hepatic - hepatic steatosis - hepatitis - hepatitis C and HIV coinfection - hepatomegaly - herpes ...
... (IVRA) or Bier's block anesthesia is an anesthetic technique on the body's extremities where a ... where there is a risk of massive hemolysis due to low oxygen tension or hemolytic crisis due to restricted blood flow).[1][4][7 ...
Haemoglobin in the blood carries oxygen from the lungs or gills to the rest of the body (i.e. the tissues). There it releases ... In hemolysis (accelerated breakdown of red blood cells), associated jaundice is caused by the hemoglobin metabolite bilirubin, ... Urobilinogen leaves the body in faeces, in a pigment called stercobilin. Globulin is metabolised into amino acids that are then ... Hemoglobin is involved in the transport of other gases: It carries some of the body's respiratory carbon dioxide (about 20-25% ...
... form large colonies (>0.5 cm) after 24 hours of incubation, and produce haemolysis on blood agar; ... rounded berry-like bodies (kokkos), referring to their usual appearance under a light-microscope. Dys (bad) galactiae (milk) ...
Hemolysis is the general term for excessive breakdown of red blood cells. It can have several causes and can result in ... c) and (d) do not normally occur in the body. The last two shapes are due to water being transported into, and out of, the ... Each circulation takes about 60 seconds (one minute).[4] Approximately a quarter of the cells in the human body are red blood ... Pernicious anemia is an autoimmune disease wherein the body lacks intrinsic factor, required to absorb vitamin B12 from food. ...
Because infusing a solution of low osmolality can cause problems such as hemolysis, intravenous solutions with reduced saline ... This solution is used for irrigating wounds, tissues, body cavities, and bladders. Saline solution for irrigation should not be ... amoeba Naegleria fowleri infection can occur if amoeba enters the body through the nose, therefore water used for nasal ...
Donald Pinkel (August 1958). "The Use of Body Surface Area as a Criterion of Drug Dosage in Cancer Chemotherapy". Cancer Res. ... hemolysis), hereditary disease, kidney dysfunction, nutritional deficiencies or anemia of chronic disease. Treatments to ... The most common medications affect mainly the fast-dividing cells of the body, such as blood cells and the cells lining the ... Cyclophosphamide is a common cytotoxic drug used in this manner, and is often used in conjunction with total body irradiation. ...
When the body is infected with streptococci, it produces antibodies against the various antigens that the streptococci produce ... The main function of streptolysin O is to cause hemolysis (the breaking open of red blood cells) - in particular, beta- ... hemolysis. Increased levels of aso titre in the blood could cause damage to the heart and joints. In most cases, penicillin is ...
Hemolysis[edit]. In medicine, LDH is often used as a marker of tissue breakdown as LDH is abundant in red blood cells and can ... LDH is a protein that normally appears throughout the body in small amounts. Many cancers can raise LDH levels, so LDH may be ... Other uses are assessment of tissue breakdown in general; this is possible when there are no other indicators of hemolysis. It ... Tissue breakdown releases LDH, and therefore LDH can be measured as a surrogate for tissue breakdown, e.g. hemolysis. LDH is ...
Autoimmune disorders can often be traced to antibodies that bind the body's own epitopes; many can be detected through blood ... Possible class effects of antibodies include: Opsonisation, agglutination, haemolysis, complement activation, mast cell ... immune body in English).[88] As such, the original construction of the word contains a logical flaw; the antitoxin is something ... which allows a B cell to detect when a specific antigen is present in the body and triggers B cell activation.[11] The BCR is ...
The "flipping" may also be driven by the rigid-body shearing of the TMDs while the hydrophobic tails of the LPS are dragged ... hemolysis, heme-binding protein, and alkaline protease), heme, hydrolytic enzymes, S-layer proteins, competence factors, toxins ... ATP binding induces a rigid body rotation of the two ABC subdomains with respect to each other, which allows the proper ... and pump drugs from the liver cells to the bile as a means of removing foreign substances from the body. A large number of ...
Kara W. Swanson, Banking on the Body: The Market in Blood, Milk, and Sperm in Modern America. Cambridge, MA: Harvard University ... a maximum auto-hemolysis threshold (currently 1% in the US), and a minimum level of post-transfusion RBC survival in vivo ( ...
Typically, there will be two or more rollers, or wipers, occluding the tube, trapping between them a body of fluid. The body of ... as the pump does not cause significant hemolysis. ...
... helps the body to metabolize carbohydrates and helps the body to metabolize fats.[115] The European Food Safety Authority (EFSA ... Hemolysis, renal, and liver failure result. Aggressive dialysis can be therapeutic.[135] ... The acute oral toxicity for chromium(VI) ranges between 1.5 and 3.3 mg/kg.[132] In the body, chromium(VI) is reduced by several ... Chromium deficiency, involving a lack of Cr(III) in the body, or perhaps some complex of it, such as glucose tolerance factor ...
Antibodies are produced when the body is exposed to an antigen foreign to the make-up of the body. If a mother is exposed to a ... Hemolysis leads to elevated bilirubin levels. After delivery bilirubin is no longer cleared (via the placenta) from the ... Acute hemolytic transfusion reactions due to immune hemolysis may occur in patients who have no antibodies detectable by ... hemolysis). The fetus can develop reticulocytosis and anemia. This fetal disease ranges from mild to very severe, and fetal ...
"Life-threatening envenoming by the Saharan horned viper (Cerastes cerastes) causing micro-angiopathic haemolysis, coagulopathy ... Foreign body. In alimentary tract (Bezoar). Other. Burn/Corrosion/Chemical burn · Frostbite · Aerosol burn · Traumatic ...
... bodies appear to become conditioned to retain iron better.[8] Mechanical hemolysis is most likely to occur in high-impact ... Total body iron averages approximately 3.8 g in men and 2.3 g in women. In blood plasma, iron is carried tightly bound to the ... Iron deficiency, or sideropaenia, is the state in which a body lacks enough iron to supply its needs. Iron is present in all ... When the body lacks sufficient amounts of iron, production of the protein hemoglobin is reduced. Hemoglobin binds to oxygen, ...
The body is 73% water, and therefore, acoustically homogeneous. Blood and surrounding tissues have similar echogenicities, so ... Microbubble destruction could cause local microvasculature ruptures and hemolysis.[7]. *Targeting ligands can be immunogenic, ... There is a great difference in echogenicity between the gas in the microbubbles and the soft tissue surroundings of the body. ...
Beta hemolysis (β-hemolysis), sometimes called complete hemolysis, is a complete lysis of red cells in the media around and ... This "cross-reaction" causes the body to essentially attack itself and leads to the damage above. A similar autoimmune ... Other synonymous terms are incomplete hemolysis and partial hemolysis. Alpha hemolysis is caused by hydrogen peroxide produced ... When alpha hemolysis (α-hemolysis) is present, the agar under the colony is dark and greenish. Streptococcus pneumoniae and a ...
Haemoglobin in blood carries oxygen from the lungs or gills to the rest of the body (i.e. the tissues). There it releases the ... In hemolysis (accelerated breakdown of red blood cells), associated jaundice is caused by the hemoglobin metabolite bilirubin, ... Urobilinogen leaves the body in faeces, in a pigment called stercobilin. Globulin is metabolised into amino acids that are then ... This is an effect of intravascular hemolysis, in which hemoglobin separates from red blood cells, a form of anemia. ...
The result of breathing increased partial pressures of oxygen is hyperoxia, an excess of oxygen in body tissues. The body is ... It may also be implicated in damage to red blood cells (haemolysis),[5][6] the liver,[7] heart,[8] endocrine glands (adrenal ... with claims of removing body toxins and reducing body fat.[127] The American Lung Association has stated "there is no evidence ... While all the reaction mechanisms of these species within the body are not yet fully understood,[55] one of the most reactive ...
Histoplasma enters the body and goes to the lungs where the spores turn into yeast.[12] The yeast gets into the blood stream ... "Microbiology with Diseases by Body System", Robert W. Bauman, 2009, Pearson Education, Inc. ... and affects lymph nodes and other parts of the body. Usually people do not get sick from inhaling the spores, but if they do ...
... intravascular hemolysis) or elsewhere in the human body (extravascular, but usually in the spleen). It has numerous possible ... Hemolytic anemia is a form of anemia due to hemolysis, the abnormal breakdown of red blood cells (RBCs), either in the blood ... Chronic hemolysis leads to an increased excretion of bilirubin into the biliary tract, which in turn may lead to gallstones. ... Certain aspects of the medical history can suggest a cause for hemolysis, such as drugs, consumption of fava beans due to ...
... is so named because it involves substances found in the humors, or body fluids. It contrasts with cell- ... This type of reaction, called an acute hemolytic reaction, results in the rapid destruction (hemolysis) of the donor red blood ... Mentioned in On the Formation of Specific Anti-Bodies in the Blood, Following Upon Treatment with the Sera of Different Animals ... An experimental investigation of the role of the body fluids in connection with phagocytosis. Proc. R. Soc. London 72:357-370. ...
... the lack of vitamin C biosynthesis may allow our bodies to know more about our nutritional status and consequently set the ... on evidence which indicates that G6PD deficient individuals display enhanced sensitivity to ascorbic acid induced hemolysis.[18 ...
In most cases it is caused by chronic, uncontrolled activation of the complement system, a branch of the body's immune system ... hemolysis (breakdown of red blood cells), damage to multiple organs, and often, death. aHUS is not the only condition that ... hemolysis, liver dysfunction, and low platelets) syndrome, and toxic drug reaction (e.g., to cocaine, cyclosporine, or ... the formation of blood clots in small blood vessels throughout the body, which can lead to stroke, heart attack, kidney failure ...
... is a type of metal poisoning caused by lead in the body.[2] The brain is the most sensitive.[2] Symptoms may ... Hemolysis (the rupture of red blood cells) due to acute poisoning can cause anemia and hemoglobin in the urine.[32] Damage to ... The main body compartments that store lead are the blood, soft tissues, and bone; the half-life of lead in these tissues is ... Lead has no known physiologically relevant role in the body,[42][78] and its harmful effects are myriad. Lead and other heavy ...
... samples from the fundus and body should be taken in these patients. ...
Erythrocyte pathology and mechanisms of Heinz body-mediated hemolysis in cats. / Christopher, Mary M; White, J. G.; Eaton, J. W ... Christopher, MM, White, JG & Eaton, JW 1990, Erythrocyte pathology and mechanisms of Heinz body-mediated hemolysis in cats., ... Christopher, Mary M ; White, J. G. ; Eaton, J. W. / Erythrocyte pathology and mechanisms of Heinz body-mediated hemolysis in ... Christopher, M. M., White, J. G., & Eaton, J. W. (1990). Erythrocyte pathology and mechanisms of Heinz body-mediated hemolysis ...
In addition to its therapeutic effects, whole-body cryotherapy has been demonstrated to be a preventive strategy against the ... In addition to its therapeutic effects, whole-body cryotherapy has been demonstrated to be a preventive strategy against the ... From a biochemical point of view, whole-body cryotherapy not always induces appreciable modifications, but the final clinical ... whole-body cryotherapy not always induces appreciable modifications, but the final clinical output (in terms of pain, soreness ...
Oxidative hemolysis and precipitation of hemoglobin. I. Heinz body. The Journal of clinical investigation. 1960;39:1818-1836. ... title = "Oxidative hemolysis and precipitation of hemoglobin. I. Heinz body",. author = "JANDL, {J. H.} and ENGLE, {L. K.} and ... Oxidative hemolysis and precipitation of hemoglobin. I. Heinz body. / JANDL, J. H.; ENGLE, L. K.; ALLEN, D. W. ... JANDL, J. H. ; ENGLE, L. K. ; ALLEN, D. W. / Oxidative hemolysis and precipitation of hemoglobin. I. Heinz body. In: The ...
... an investigational monoclonal antibody for the treatment of hemolysis in adults with cold agglutinin disease. The CRL refers to ... an investigational treatment for hemolysis in adults with cold agglutinin disease * Complete Response Letter refers to ... Harvard gets its first Black, elected student body president. A 20-year-old from Mississippi has become the first Black, ... FDA issues Complete Response Letter for sutimlimab, an investigational treatment for hemolysis in adults with cold agglutinin ...
Running long distances can be hard on the body, but as one ultramarathoner found out, it can also take a toll on an ... Running long distances can be hard on the body, but as one ultramarathoner found out, it can also take a toll on an ... Footstrike hemolysis is not only seen in long-distance runners: It has also been observed in other types of athletes, such as ... Footstrike Hemolysis: How Running Changed One Mans Blood Cells. By Cari Nierenberg 26 December 2017. ...
Hemolysis: This is the breakdown of red blood cells. These cells carry oxygen from your lungs to your body. ...
Hemolysis may occur in vivo or in vitro (inside or outside the body). One cause of hemolysis is the action of hemolysins, ... essentially this is hemolysis occurring outside of the body. Unfortunately, increased hemolysis occurs with massive amounts of ... Hemolysis inside the body can be caused by a large number of medical conditions, including many Gram-positive bacteria (e.g., ... Extravascular hemolysis refers to hemolysis taking place in the liver, spleen, bone marrow, and lymph nodes. In this case ...
So your body breaks them down. Scientists call this process "hemolysis.". Some doctors believe PNH is related to weak bone ... Eat a healthy diet . Your body absorbs iron better when you get it with vitamin C. Try combos like iron-fortified cereal with ... If you have it, your immune system attacks red blood cells in your body and breaks them down. They lack certain proteins that ... A change in a gene, called a mutation, causes your body to make abnormal red blood cells. These cells dont have proteins that ...
Acute anemia ddx // Lifespan of an RBC // Body cavities where blood can accumulate // Causes of rapid hemolysis // 3 broad ...
LDH (lactate dehydrogenase) is an enzyme that helps body tissues to produce energy. LDH is present in almost all body tissues. ... Hemolysis, the breakdown of red blood cells, is a characteristic feature of HELLP syndrome. Abnormal peripheral smear with low ...
3 mL whole blood or 2 mL bone marrow aspirate, 2 mL body fluid tube. Large volumes of body fluids should be concentrated to ,5 ... Hemolysis; specimen clotted; specimen frozen; specimen in formalin or other fixative; blood more than 72 hours old; bone marrow ... Whole blood, bone marrow aspirate, body fluids, fresh lymph node, spleen, extranodal solid tissue, biopsy, or needle aspirate ... EDTA body fluids) tube; fresh tissue in lymph node transport bottle containing RPMI ...
Lysis (destruction) or red blood cells (see also "hemolysis").. Intubation. Insertion of a tube into a hollow organ or body ... Affecting the body generally; not localized.. Systemic agent. A substance with whole-body (systemic) or multi-organ-system ... Hemolysis. Lysis (destruction) of red blood cells (see also "intravascular hemolysis").. Hemolytic anemia. Anemia caused by the ... A minute body found in the blood of mammals that functions to promote blood clotting; also called thrombocyte.. ...
anything recognized as foreign to the body. hemolysis. rupturing of RBC during collection. ...
Also called warm hemolysis, this involves IgG antibodies. These bind red blood cells at 98.6°F (37°C), or normal body ... Anemia occurs when the body lacks red blood cells. A person may have a condition that destroys these cells, or the body may not ... Iron is a vital mineral in the body, central to transporting oxygen around the body in the hemoglobin. A shortage of iron can ... In AIHA, the body makes antibodies that attack the red blood cells because they think they are foreign or unwanted substances. ...
Hematologic: hemolysis, positive direct antiglobulin (Coombs) test. General/Body as a Whole: pyrexia, rigors ... Hemolysis. Immune Globulin Intravenous (Human) [IGIV] products can contain blood group antibodies which may act as hemolysins ... Hemolysis following intravenous immune globulin therapy. Transfusion. 1986;26:410-412.. 22. Thomas MJ, Misbah SA, Chapel HM, ... If signs and/or symptoms of hemolysis are present after IGIV infusion, appropriate confirmatory laboratory testing should be ...
It is important to centrifuge immediately after collection to separate the plasma from the blood cells. If immediate centrifugation is not possible, collected blood specimens should be kept on ice and centrifuged within an hour ...
Help us protect our patients, families and staff from RSV and the flu by following these visitation restrictions currently in effect.. ...
The sugar-water hemolysis test is a blood test to detect fragile red blood cells. It does this by testing how well they ... Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some ... Sucrose hemolysis test; Hemolytic anemia sugar water hemolysis test; Paroxysmal nocturnal hemoglobinuria sugar water hemolysis ... The sugar-water hemolysis test is a blood test to detect fragile red blood cells. It does this by testing how well they ...
The reduction of nitric oxide deeply disturbs the bodys mechanism to maintain the stability of the hemodynamics. Additionally ... Intravascular hemolysis describes hemolysis that happens mainly inside the vasculature. As a result, the contents of the red ... Intravascular hemolysis is the state when the red blood cell ruptures as a result of the complex of complement autoantibodies ... Schaer, D. J.; Buehler, P. W.; Alayash, A. I.; Belcher, J. D.; Vercellotti, G. M. (2012-12-20). "Hemolysis and free hemoglobin ...
Diuretic- Medication that increases the urine output of the body.. Electrolytes- Salts and minerals that produce electrically ... Hemolysis -The process of breaking down red blood cells. As the cells are destroyed, hemoglobin, the component of red blood ... Electrolytes are mineral salts that form electrically charged particles (ions) in body fluids; they help control body fluid ... Electrolytes are important because they control body fluid balance and are important for all major body reactions. Pharmacists ...
Hemolysis is a breakdown of the bodys red blood cells, typically as a result of disease or taking certain medications. It ... Hemolysis is the abnormal breakdown of the bodys red blood cells. Health. Medicine. Fitness. Anatomy. Science. Food. ... The abnormal breakdown of the bodys red blood cells is known as hemolysis. The presence of certain diseases can contribute to ... My blood test says: hemolysis 4+ abnormal. What does the 4+ mean? Post your comments. Please enter the following code: ...
Hemolysis. * Heinz body in cats and dogs stained with NMB. *elevated liver enzymes ... Browse over 1 million classes created by top students, professors, publishers, and experts, spanning the worlds body of " ... Cats primarily develop methemogloninemia within a few hours, followed by Heinz body formation ...
... deficiency is a condition in which red blood cells break down when the body is exposed to certain drugs or the stress of ... This form is also associated with acute episodes of hemolysis. Episodes are longer and more severe than in the other types of ... Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a condition in which red blood cells break down when the body is exposed ... This process is called hemolysis. When this process is actively occurring, it is called a hemolytic episode. The episodes are ...
... for effects of hypoxia and hemolysis. A Heinz-body hemolytic crisis may follow the development of methemoglobinemia by 2 to 7 ... "Body bags" are not recommended. Report to the base station and the receiving medical facility the condition of the patient, ... The standard intravenous dose is 1 to 2 mg of methylene blue per kg of body weight (0.1 to 0.2 mL/kg of a 1% solution) over 5 ... The standard dose of methylene blue is 1 to 2 mg/kg body weight (0.1 to 0.2 mL/kg of a 1% solution) intravenously over 5 to 10 ...
... hemolysis) causes significant reductions in RBCs, Hgb, iron levels, and the essential delivery of oxygen to body tissues. ... In cold antibody hemolytic anemia, the body attacks red blood cells at or below normal body temperature. The acute form of this ... In cold antibody hemolytic anemia, the body attacks red blood cells at or below normal body temperature. The acute form of this ... The Oxford Companion to the Body © The Oxford Companion to the Body 2001, originally published by Oxford University Press 2001. ...
Jaundice from hemolysis. If your baby has Rh disease (hemolytic disease of the newborn due to having a different blood type ... This makes bilirubin build up in your babys body. Babies born between 34 to 36 weeks of pregnancy are more likely to get this ... Hemolysis is the word for the process in which the red blood cells break down and release bilirubin. ... The liver is the part of the body most responsible for getting rid of bilirubin. A problem with the liver can cause higher ...
... and acute hemolysis, consistent with intravascular hemolysis, has been reported.9 ... For example, if a patient with a body weight of 70 kg has an actual IgG trough level of 900 mg/dL and the target trough level ... Hemolysis. Hizentra can contain blood group antibodies that may act as hemolysins and induce in vivo coating of red blood cells ... General/Body as a Whole: Pyrexia, rigors. To report SUSPECTED ADVERSE REACTIONS, contact CSL Behring Pharmacovigilance at 1-866 ...
Blister and bite cells during hemolysis. - Heinz bodies Crystal violet supravital stain ... All factors of intravascular hemolysis present. - Blister cells: precipitates of hemoglobin that are so dense they wont take ... Browse over 1 million classes created by top students, professors, publishers, and experts, spanning the worlds body of " ... In HS, loss of membrane causes hemolysis to occur at higher concentrations (0.7%) ...
Message Body (Your Name) thought you would like to see the American Academy of Pediatrics web site. ... Conservative Management of Alloimmune Hemolysis and Cholestasis With Extreme Laboratory Abnormalities. Chelsea Kotch, David F. ... Conservative Management of Alloimmune Hemolysis and Cholestasis With Extreme Laboratory Abnormalities. Chelsea Kotch, David F. ... Hemolysis and Neurologic Impairment in PAMI Syndrome: Novel Characteristics of an Elusive Disease ...
  • Intravascular hemolysis describes hemolysis that happens mainly inside the vasculature. (
  • Intravascular hemolysis is the state when the red blood cell ruptures as a result of the complex of complement autoantibodies attached (fixed) on the surfaces of RBCs attack and rupture RBCs' membranes, or a parasite such as Babesia exits the cell that ruptures the RBC's membrane as it goes. (
  • In the end, if the plasma concentration of the "free met-hemoglobin" and/or "free hemoglobin" is still too high for proximal tubule to absorb back into the body, then hemoglobinuria occurs, indicating an extensive intravascular hemolysis. (
  • It is important to note that although hemosiderins are also included in the urine in the setting of intravascular hemolytic hemoglobinuria, it will be detected only several days after the onset of the extensive intravascular hemolysis and will remain detectable several days after termination of intravascular hemolysis. (
  • The phenomenon tells that the detection of hemosiderin in urine is indicative of either ongoing or recent intravascular hemolysis characterized by excessive hemoglobin and/or met-hemoglobin filtered through the renal glomerulus as well as the loss of hemosiderin-laden necrotic tubular cells. (
  • The most anemic dogs had evidence of intravascular hemolysis. (
  • Exposure to cold may enhance binding of cold agglutinins and complement mediated release of hemoglobin within the vessels (intravascular hemolysis). (
  • Paroxysmal nocturnal hemoglobinuria (PNH) patients display exaggerated intravascular hemolysis and esophageal disorders. (
  • Since excess hemoglobin in the plasma causes reduced nitric oxide (NO) bioavailability and oxidative stress, we hypothesized that esophageal contraction may be impaired by intravascular hemolysis. (
  • This study aimed to analyze the alterations of the esophagus contractile mechanisms in a murine model of exaggerated intravascular hemolysis induced by phenylhydrazine (PHZ). (
  • For comparative purposes, sickle cell disease (SCD) mice were also studied, a less severe intravascular hemolysis model. (
  • In endothelial nitric oxide synthase gene-deficient mice, the contractile responses elicited by KCl and CCh were increased in the esophagus but remained unchanged with the intravascular hemolysis induced by PHZ. (
  • Moreover, our study supports the hypothesis that esophageal disorders in PNH patients are secondary to intravascular hemolysis affecting the NO-cGMP pathway. (
  • Background Paroxysmal nocturnal hemoglobinuria is an acquired hemolytic anemia characterized by intravascular hemolysis which has been demonstrated to be effectively controlled with eculizumab. (
  • 1 , 2 This lack of GPI expression results in the loss of the terminal complement inhibitor CD59 from the surface of hematopoietic cells, leaving red blood cells susceptible to complement-mediated intravascular hemolysis and unregulated activation of platelet and endothelial cells. (
  • 8 - 10 Pulmonary hypertension, a known complication in patients with the hemolytic sub-phenotype of SCD, is thought to be caused by vasculopathy related to the chronic nitric oxide depletion from continuing intravascular hemolysis. (
  • Patients may experience episodes of intravascular hemolysis and consequent anemia, triggered by infections, medicines that induce oxidative stresses, fava beans, and ketoacidosis. (
  • Oxidative hemolysis and precipitation of hemoglobin. (
  • Hemolysis can lead to hemoglobinemia due to hemoglobin released into the blood plasma, which plays a significant role in the pathogenesis of sepsis and can lead to increased risk of infection due to its inhibitory effects on the innate immune system. (
  • However, during hyper-hemolytic conditions or with chronic hemolysis, haptoglobin is depleted so the remaining free hemoglobin readily distribute to tissues where it might be exposed to oxidative conditions, thus some of the ferrous heme (FeII), the oxygen-binding component of hemoglobin, of the free hemoglobin are oxidized and becoming met-hemoglobin (ferric hemoglobin). (
  • Red blood cells transport oxygen throughout the body in the form of hemoglobin. (
  • Anemia is a blood disorder characterized by abnormally low levels of healthy red blood cells (RBCs) or reduced hemoglobin (Hgb), the iron-bearing protein in red blood cells that delivers oxygen to tissues throughout the body. (
  • Your body makes bilirubin when it breaks down hemoglobin. (
  • The breakdown of hemoglobin is called hemolysis. (
  • Every second, our body recycles over 1000 trillion heme-iron obtained from breaking down hemoglobin from dying red blood cells," says Hamza. (
  • In children with SCA, significant associations have been found between proteinuria and the hemolysis markers of low hemoglobin (Hb) and high lactate dehydrogenase (LDH). (
  • It is generally accepted that an acute drop in hemoglobin to a level of 7-8 g/dL is symptomatic, whereas levels of 4-5 g/dL may be tolerated in chronic anemia, as the body is able to gradually replace the loss of intravascular volume. (
  • In response to oxidative stress, hemoglobin S polymerizes, leading to sickling and hemolysis (see the image below). (
  • Bilirubin is an orange yellow bile pigment that is produced as a byproduct of hemoglobin as red blood cells break down (hemolysis). (
  • In conclusion, our results show that esophagus hypercontractile state occurs in association with lower NO bioavailability due to exaggerated hemolysis intravascular and oxidative stress. (
  • G6PD deficiency leads to free radical-mediated oxidative damage to red blood cells, which in turn causes hemolysis. (
  • Hemolysis begins 24-72 hours after exposure to oxidative stress. (
  • The clinical presentation of G6PD deficiency includes a spectrum of hemolytic anemia ranging from mild to severe hemolysis in response to oxidative stress. (
  • The mutation deficiency alters G6PD enzyme function ( 2 ), exposing red blood cells to oxidative stress and resultant hemolysis in the presence of a stressor, such as primaquine ( 3 , 4 ). (
  • The abnormal breakdown of the body's red blood cells is known as hemolysis. (
  • In some cases, the body may suddenly start rapidly destroying blood cells, a condition known as hemolysis or hemolytic anemia. (
  • The red blood cell is destroyed in a process known as hemolysis, resulting in hemolytic anemia. (
  • this is known as hemolysis . (
  • If the liver cannot process the bilirubin fast enough, it will build up in the body and cause jaundice, explains Keep Kids (
  • In both cases, bilirubin builds up in the body and causes jaundice. (
  • Jaundice is a common condition in newborn babies, which happens due to excessive production of a chemical in the body called bilirubin. (
  • In diseases because of the different enzymes which are probably absent or not working properly in the body can also cause pathological jaundice. (
  • When a baby has jaundice or hyperbilirubinemia, this can indicate that the baby's body is producing excess bilirubin or that the liver is too immature to be able to eliminate bilirubin fast enough. (
  • Despite the frequency of both oxidant drug-induced and spontaneous Heinz body formation in cats, the cellular and biochemical mechanisms by which Heinz bodies result in red blood cell (RBC) destruction and hemolytic anemia in this species remain unknown. (
  • We investigated several aspects of Heinz body-containing RBC from three cats ingesting diets that provided 8.0 g PG/kg body weight for up to 3 weeks, in order to characterize cellular lesions that are associated with the presence of Heinz bodies and that might contribute to chronic, accelerated RBC destruction, as well as to gain insight into the mechanism by which PG induces Heinz body formation. (
  • Progressively protruding Heinz bodies suggested that extrusion of Heinz bodies may be a means of cell healing and/or destruction in the absence of splenic pitting. (
  • Runners can suffer hemolytic anemia due to "footstrike hemolysis", the destruction of red blood cells in feet at foot impact. (
  • These symptoms are due to a combination of dehydration , anemia (due to the destruction of red blood cells and low platelet counts), and uremia (the inability of the kidneys to clear waste products from the body). (
  • Hemolysis describes the destruction of red blood cells. (
  • This destruction of red blood cells is called hemolysis. (
  • Anemia develops when either blood loss, a slow-down in the production of new RBCs (erythropoiesis), or an increase in red cell destruction (hemolysis) causes significant reductions in RBCs, Hgb, iron levels, and the essential delivery of oxygen to body tissues. (
  • A certain amount of RBC destruction, or hemolysis, is normal. (
  • Destruction of the cells (hemolysis) eventually results. (
  • Superoxide anion was found to be unimportant in phenylhydrazine-induced hemolysis and destruction of oxyhemoglobin. (
  • Our results indicate that multiple cellular abnormalities develop in RBC with PG-induced Heinz bodies that do not cause acute hemolysis but that may shorten RBC survival. (
  • This form is also associated with acute episodes of hemolysis. (
  • This leads to hemolysis during acute illnesses, such as infections, or upon exposure to fava beans or certain drugs. (
  • All present sterility tests concerning bacteria and viruses (including endotoxin) yielded negative results, and all evaluations of cell toxicity, sensitization, chromosomal aberrations, intracutaneous reactions, acute systemic toxicity, pyrogenic reactions, and hemolysis were negative according to the criteria of the ISO and the Ministry of Health, Labour and Welfare of Japan. (
  • Acute anemia denotes a precipitous drop in the RBC population due to hemolysis or acute hemorrhage. (
  • A presumptive diagnosis of acute haemolysis due to G6PD deficiency was made and the child received 1 blood transfusion and folic acid after which he recovered fully. (
  • Glucose-6-phosphate dehydrogenase deficiency (also called G6PD Deficiency) is a genetic disorder that mainly affects red blood cells , which carry oxygen from the lungs to tissues throughout the body. (
  • The most common medical problem associated with glucose-6-phosphate dehydrogenase deficiency is hemolytic anemia, which occurs when red blood cells are destroyed faster than the body can replace them. (
  • Patients at high risk of IVIG-associated hemolysis (defined as receipt of a 28-day cumulative dose of ≥ 2 g/kg, adjusted for ideal body weight, and non-O blood group) will be prospectively monitored using a standardized protocol for signs of hemolysis, and will be undergo additional testing for variables that have been hypothesized to increase the risk of hemolysis. (
  • This may result in haemolysis, the formation of methaemoglobin and kidney impairment. (
  • It is an X-linked recessive inborn error of metabolism which can result in haemolysis on exposure to a number of triggers, such as some infections, and certain medicines and foods. (
  • The liver is the part of the body most responsible for getting rid of bilirubin. (
  • Heart, liver, and kidney effects may be secondary to hemolysis. (
  • Your liver removes bilirubin from your body. (
  • After bilirubin is cleared from the blood by the liver, it passes through small ducts to the intestines in a body fluid called bile. (
  • Liver regulates the production and removal of bilirubin in the body. (
  • Severe poisoning is associated with the development of renal failure, intravascular haemolysis (usually manifest 24-48 hours post-poisoning) and cellular and obstructive liver damage. (
  • This phenomenon - which is diagnosed mostly in endurance athletes - occurs when people repeatedly land on their feet with the force of their body weight, such as when they're running. (
  • Compensated hemolysis occurs when the bone marrow is able to restore balance during the early stages of red blood cell disruption, ultimately, preventing the onset of anemia. (
  • A chemical substance (such as a drug) that is capable of combining with a receptor on a cell and initiating the same reaction or activity typically produced by the binding of a substance that normally occurs in the body (i.e., is endogenous). (
  • In some autoimmune diseases, hemolysis occurs when the body makes antibodies that attack its own RBCs. (
  • In addition to vaso-occlusion, chronic hemolysis is also a fundamental pathological process that occurs in SCA. (
  • M. hyorhinis also possesses antagonistic cooperativity (reverse CAMP phenomenon) with Staphylococcus aureus beta-hemolysis, resulting in the protection of erythrocytes from the beta-hemolytic activity of S. aureus (reverse CAMP). (
  • In Clostridium perfringens ( 12 ) and Corynebacterium pseudotuberculosis ( 13 , 14 ), however, the rare antagonistic interaction (reverse CAMP phenomenon) was described where the beta-hemolysis of staphylococci was inhibited, apparently through the activity of a phospholipase D (PLD) ( 14 ). (
  • 5). S. pyogenes produces beta hemolysis when placed on a blood agar plate. (
  • In the case, which was published Dec. 13 in the journal BMJ Case Reports , a 41-year-old man who regularly trained for and competed in 50- to 100-mile ultramarathons was diagnosed with a condition called "footstrike hemolysis. (
  • Footstrike hemolysis is not only seen in long-distance runners: It has also been observed in other types of athletes, such as cyclists and swimmers, and in nonathletes, such as soldiers after a strenuous march, DeGeorge said. (
  • Thereafter, these complexes will undergo the metabolic mechanisms like extravascular hemolysis. (
  • It happens when the body produces antibodies that destroy the red blood cells. (
  • Antibodies attach to red blood cells and travel throughout the body, fighting germs and other foreign substances that should not be there. (
  • In AIHA, the body makes antibodies that attack the red blood cells because they think they are foreign or unwanted substances. (
  • Also called warm hemolysis, this involves IgG antibodies. (
  • Hemolytic disease of the newborn is the commonest manifestation of hemolysis due to antibodies. (
  • When red blood cells are the target of antibodies and complement, a condition called hemolysis results. (
  • 6. Intravascular haemolysis and renal failure are managed conventionally. (
  • Factors such as infections, certain drugs , or ingesting fava beans can increase the levels of reactive oxygen species, causing red blood cells to be destroyed faster than the body can replace them. (
  • If your vet detects hemolytic anemia or the formation of Heinz bodies on a blood smear, and that is combined with a recent history of onion exposure, then all signs point toward onion toxicity. (
  • The therapy, called whole-body cryotherapy (WBC), consists of exposure to very cold air that is maintained at -110 degrees C to -140 degrees C in special temperature-controlled cryochambers, generally for 2 minutes. (
  • Hereditary conditions, such as sickle cell disease and G6PD deficiency disorder, may also contribute to the development of hemolysis. (
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a condition in which red blood cells break down when the body is exposed to certain drugs or the stress of infection. (
  • The deficiency begins when the body loses more iron than it derives from food and other sources. (
  • Then the body tries to compensate for the iron deficiency by producing more red blood cells, which are characteristically small in size (spherocytosis). (
  • Folic acid deficiency anemia is the most common type of megaloblastic anemia, arising from a problem with the synthesis of deoxyribonucleic acid (DNA) within the cells of the body. (
  • It is characterized by RBCs that are larger than normal and is caused by a deficiency of folic acid, a vitamin that the body needs to produce normal cells and normal DNA. (
  • G6PD screening revealed deficiency, taken at the time of maximal haemolysis and after six weeks follow up (Hb was then 124 g/l). (
  • Percentage of Female Participants With Moderate Glucose-6 Phosphate Dehydrogenase (G6PD) Deficiency Experiencing Clinically Relevant Hemolysis. (
  • The likelihood of developing hemolysis and its severity depend on the level of the enzyme deficiency, which in turn depends on the G6PD variant. (
  • We report on a 6-year-old boy, previously undiagnosed with G6PD deficiency, who developed life-threatening haemolysis after application of henna to his skin. (
  • Conclusions These data demonstrate a previously masked mechanism of red cell clearance in paroxysmal nocturnal hemoglobinuria and suggests that blockade of complement at C5 allows C3 fragment accumulation on some paroxysmal nocturnal hemoglobinuria red cells, explaining the residual low-level hemolysis occurring in some eculizumab-treated patients. (
  • The resulting chronic hemolysis in PNH leads to a syndrome of debilitating morbidities that includes severe anemia, disabling fatigue, thromboembolism, renal impairment, abdominal pain, dysphagia, hemoglobinuria and deteriorating quality of life. (
  • Because in vivo hemolysis destroys red blood cells, in uncontrolled, chronic or severe cases it can lead to hemolytic anemia. (
  • One cause of hemolysis is the action of hemolysins, toxins that are produced by certain pathogenic bacteria or fungi. (
  • Defensin concentrations that inhibited hemolysis by ALO and listeriolysin did not prevent these toxins from binding either to red blood cells or to cholesterol. (
  • Propylene glycol-induced Heinz bodies provide an ideal model for studying the chronic effects of Heinz bodies on RBC structure and function and may be useful in understanding the mechanisms of formation and the consequences of endogenous Heinz bodies in cats. (
  • If you have it, your immune system attacks red blood cells in your body and breaks them down. (
  • An antigen is any substance which can provoke an immune response in the body. (
  • Therefore, IMHA is a condition in which red blood cells are attacked by the body's immune system and destroyed by hemolysis, resulting in anemia (an inadequate quantity of red blood cells). (
  • Paxillus Involutus ingestion can cause hemolysis. (
  • The substance can be absorbed into the body by inhalation, through the skin and by ingestion. (
  • In diseases with abnormally shaped RBCs, such as sickle cell anemia or spherocytosis, the body identifies the cells as abnormal and destroys them prematurely. (
  • C. PA abdominal film demonstrates characteristic erosive changes (demineralization, flattening and biconcave configuration) in the vertebral bodies accompanying sickle cell. (
  • Studies have questioned whether renal dysfunction in sickle cell disease is linked to hemolysis-associated vasculopathy. (
  • We have investigated renal function and markers of hemolysis in a cohort of 424 adult African-British patients with sickle cell disease. (
  • Vienna, 31 October 2016) Worldwide, millions of people suffer from hemolysis, the breakdown of red blood cells, such as those afflicted with sickle-cell disease, malaria or sepsis. (
  • The loss of cytoskeletal resilience results in life-threatening conditions for millions of people worldwide, which suffer from hemolysis due to systemic inflammation (sepsis) or disorders such as sickle-cell disease, or malaria. (
  • Hydrodynamic stresses resulting from acoustically induced small-scale eddying motion near the bubble may be the mechanism of hemolysis. (
  • With his latest publication in eLife , Hamza has discovered a never-before-seen protection mechanism in mammals against the toxicity of free heme in the body - the production of a crystallized form of heme known as hemozoin. (
  • From a biochemical point of view, whole-body cryotherapy not always induces appreciable modifications, but the final clinical output (in terms of pain, soreness, stress, and post-exercise recovery) is very often improved compared to either the starting condition or the untreated matched group. (
  • They found that drinking silicon-rich mineral water can help rid the body of aluminum and may be beneficial for patients with Alzheimer's disease in the long run. (
  • In their study, Exley and his colleagues hypothesized that silicon-rich mineral water can be used to reduce the body burden of aluminum in patients with Alzheimer's . (
  • The goal of the study is to define the incidence and dynamics of IVIG-mediated hemolysis and identify patient and product-related factors that may predict which patients are especially at risk. (
  • Monitor patients for hemolysis and hemolytic anemia. (
  • However, lactate dehydrogenase levels remain slightly elevated and haptoglobin levels remain low in some patients suggesting residual low-level hemolysis. (
  • This study puts to rest the old belief that iron availability favors bacterial infections in hemolytic disorders, and moreover reveals a new treatment approach to protect patients with hemolysis from infections. (
  • For decades, iron has been considered the prime suspect responsible for the high rate of bacterial infections in patients with hemolysis (bursting of red blood cells). (
  • Taking that into consideration, the traditional hypothesis predicted that since hemolysis leads to the release of iron-containing heme, the threat of serious bacterial infections in these patients was attributed to the excess availability of circulating iron (heme). (
  • White blood cells help the body to fight off fight infections. (
  • It is the cause of all group A streptococcal infections that can infect a number of body systems (4,5). (
  • In the latest edition of Nature Immunology, Sylvia Knapp's Group at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and the Medical University of Vienna, uncovers the molecular mechanisms that explain how hemolysis escalates the risk for infections. (
  • Hemolytic anemia develops when there are not enough red blood cells because the body destroys them sooner than it should. (
  • With a concentration of 0.4 per cent NaCl a decrease in hemolysis takes place concomitant with an increase in concentrations of sodium lactate. (
  • With still lower concentrations of NaCl, hemolysis was intensified to such an extent that with 0.3 per cent NaCl hemolysis was complete notwithstanding the addition of 1:1,000 lactic acid and that with 0.2 per cent NaCl it was complete with 1:500 lactic acid, lactic acid being used in the form of sodium lactate solution. (
  • Erythrocytes with PG-induced Heinz bodies had decreased levels of reduced glutathione and adenosine triphosphate and reduced deformability. (
  • Hemolysis or haemolysis (/hiːˈmɒlɪsɪs/), also known by several other names, is the rupturing (lysis) of red blood cells (erythrocytes) and the release of their contents (cytoplasm) into surrounding fluid (e.g. blood plasma). (
  • Within one day following a single oral dose of dehydrated onions, dogs were found to have large numbers of Heinz bodies within erythrocytes. (
  • The percentage of erythrocytes that contained Heinz bodies increased slightly to a maximum on day 3 and then declined. (
  • Hemolysis is the lysing (bursting) of red blood cells, also known as erythrocytes. (
  • Individuals experiencing hemolysis-induced anemia may develop a variety of symptoms. (
  • Puerperal Sepsis is diagnosed based on accumulation of the symptoms listed above and an examination of the body systems involved. (
  • Hemolysis inside the body can be caused by a large number of medical conditions, including many Gram-positive bacteria (e.g. (
  • Haemolytic Streptococci are bacteria that produce active haemolysins causing a clear zone of hemolysis on a blood agar medium in the area of the colony (2). (
  • Exclusion criteria include the presence of an alternate cause of anemia, including blood loss, other drug-induced hemolysis, anemia associated with chemotherapy for cancer, or hemolysis associated with an underlying disease or participation in another ongoing study. (
  • Erythrocyte pathology and mechanisms of Heinz body-mediated hemolysis in cats. (
  • Fingerprint Dive into the research topics of 'Erythrocyte pathology and mechanisms of Heinz body-mediated hemolysis in cats. (
  • Lead can affect virtually every organ or system in the body through mechanisms that involve fundamental biochemical processes. (
  • The blood vessels in the pulmonary circulation carry the blood through the lungs to pick up oxygen and get rid of carbon dioxide, while the blood vessels in the systemic circulation carry the blood throughout the rest of our body. (
  • Message Body (Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics. (
  • When compared to results obtained using RBC from cats treated with the oxidant drug phenylhydrazine, significant differences were noted in packed cell volume, turbidity index, membrane heme, and morphologic appearance of Heinz bodies. (
  • Complications associated with hemolysis and hemolytic anemias may include infection, kidney failure, and cardiovascular failure. (
  • Hemolytic uremic syndrome (HUS) is a disease of two body systems, the blood stream and the kidney. (
  • Cold agglutinins with low thermal capacity are usually associated with direct red blood cell agglutination ( adhesion ) at low body temperatures in the peripheral blood vessel network (i.e., the vessels outside of the main circulatory network). (
  • High thermal amplitude cold agglutinins (rare) may cause sustained hemolysis, but the resulting anemia is often mild and stable. (
  • Hemolysis, the breakdown of red blood cells, is a characteristic feature of HELLP syndrome. (
  • The yellow color is the result of a substance called bilirubin that is usually found in low levels in the body from the breakdown of red blood cells. (
  • This is a harmful condition and is caused due to abnormal breakdown of red blood cells in baby's body. (
  • Lead accumulates in blood, such that bone lead accounts for approximately 73% of the body burden in children, increasing to 94% in adults. (
  • The treatment does not enhance bone marrow production and could reduce the sport-induced haemolysis. (
  • This reduces the ability of the red blood cells to carry oxygen, and also tricks your dog's body into thinking that the blood cell is an invader. (
  • The pathophysiology of IVIG-associated hemolysis will be characterized by tracking changes in serum complement levels, performing extended cytokine profiling, and conducting mononuclear phagocyte activity assays using patient monocytes. (
  • Sucrose hemolysis test - diagnostic. (
  • There are a variety of diagnostic tests used to confirm the presence of hemolysis and hemolytic anemia. (
  • Red blood cells help transport oxygen throughout the body. (
  • It has a specific function of transporting oxygen throughout the body. (
  • Gamma-hemolytic, or non-hemolytic, species do not cause hemolysis and rarely cause illness. (
  • the body may not be making new red blood cells quickly enough, the dog may experience some type of bleeding (either obvious or internal), or some organism or illness may be killing off the red blood cells. (
  • LDH (lactate dehydrogenase) is an enzyme that helps body tissues to produce energy. (
  • With sodium lactate of pH = 7 alone hemolysis occurred at a concentration of about 1:200 to 1:300. (
  • Lactate dehydrogenase was assayed to assess the degree of hemolysis. (
  • This often starts on a baby's face and moves down his or her body. (
  • At 20 days the mother applied henna to the baby's whole body. (