Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Compounds based on N-phenylacetamide, that are similar in structure to 2-PHENYLACETAMIDES. They are precursors of many other compounds. They were formerly used as ANALGESICS and ANTIPYRETICS, but often caused lethal METHEMOGLOBINEMIA.
2-(2,2-Dicyclohexylethyl)piperidine. Coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
Tests used in the analysis of the hemic system.
Chemical, spectroscopic, or microscopic detection of extremely small amounts of blood.
The human being as a non-anatomical and non-zoological entity. The emphasis is on the philosophical or artistic treatment of the human being, and includes lay and social attitudes toward the body in history. (From J. Cassedy, NLM History of Medicine Division)
Native, inorganic or fossilized organic substances having a definite chemical composition and formed by inorganic reactions. They may occur as individual crystals or may be disseminated in some other mineral or rock. (Grant & Hackh's Chemical Dictionary, 5th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Endoscopic examination, therapy or surgery of the luminal surface of the colon.
Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.
An organoplatinum compound that possesses antineoplastic activity.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Organic compounds which contain platinum as an integral part of the molecule.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Dimers found in DNA chains damaged by ULTRAVIOLET RAYS. They consist of two adjacent PYRIMIDINE NUCLEOTIDES, usually THYMINE nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block DNA REPLICATION.
Discussions, descriptions or catalogs of public displays or items representative of a given subject.
Persons as individuals (e.g., ABORTION APPLICANTS) or as members of a group (e.g., HISPANIC AMERICANS). It is not used for members of the various professions (e.g., PHYSICIANS) or occupations (e.g., LIBRARIANS) for which OCCUPATIONAL GROUPS is available.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Persons whose profession is to give legal advice and assistance to clients and represent them in legal matters. (American Heritage Dictionary, 3d ed)
Inhaling and exhaling the smoke from CANNABIS.
A belief or practice which lacks adequate basis for proof; an embodiment of fear of the unknown, magic, and ignorance.
Research, Center for Drug Evaluation and (2019-12-20). "Aidaccess.org - 575658 - 03/08/2019". Center for Drug Evaluation and ... Reproductive Health and Research, issuing body. Health worker roles in providing safe abortion care and post-abortion ... Aid Access was sent a letter by the United States Food and Drug Administration (FDA) on March 8, 2019 warning Aidaccess.org to ... rather than a broader attempt to curb online drug sales. In response to this letter, 117 member of Congress sent a letter ...
Evaluation of: Astrup A, Breum L, Jensen TJ, Kroustrup JP, Larsen TM. Effect of tesofensine on bodyweight loss, body ... "Role of the increased noradrenergic neurotransmission in drug self-administration". Drug and Alcohol Dependence. 82 (2): 151-7 ... Evaluation of: Astrup A, Breum L, Jensen TJ, Kroustrup JP, Larsen TM. Effect of tesofensine on bodyweight loss, body ... This is approximately twice the weight loss produced by medications currently approved by the US Food and Drug Administration ( ...
Evaluation of: Astrup A, Breum L, Jensen TJ, Kroustrup JP, Larsen TM. Effect of tesofensine on bodyweight loss, body ... www.fda.gov/drugs/fda-drug-safety-podcasts/fda-requests-withdrawal-weight-loss-drug-belviq-belviq-xr-lorcaserin-market#:~:text= ... Increase of the body's metabolism. Interference with the body's ability to absorb specific nutrients in food. For example, ... "FDA approves weight-management drug Qsymia" (Press release). U.S. Food and Drug Administration. 17 July 2012. "Contrave ...
Research: methodology and design of psychopharmacology research, interpretation and evaluation, FDA drug development and other ... Such certifying bodies, view psychopharmacology training (either to prescribe or consult) as one component of the training of a ... Medical psychology is the application of psychological principles to the practice of medicine, primarily drug-oriented, for ... A medical psychologist who holds prescriptive authority for specific psychiatric medications and other pharmaceutical drugs ...
Evaluation and follow-up of drug-induced pulmonary toxicity (e.g. Bleomycin, Amiodarone) Evaluation of patients who are not ... The body generally handles Ga3+ as though it were ferric iron (Fe-III), and thus the free isotope ion is bound (and ... "Drug Trials Snapshots: Ga-68-DOTATOC". U.S. Food and Drug Administration (FDA). 21 August 2019. Retrieved 17 March 2020. This ... "Drug Approval Package: Gallium Ga 68 PSMA-11". U.S. Food and Drug Administration (FDA). 16 December 2020. Retrieved 25 December ...
The clinical evaluation should include a patient history that assesses the following: *History of LP involving other body sites ... Oral lichenoid drug reaction[edit]. Lichenoid drug eruptions may be caused by a variety of systemic medications and share ... to evaluate for the possibility of an oral lichenoid drug eruption. *History of dental restorations,[46] use of dental ... Medication the patients are taking within the few weeks to months after drug initiation eg. antihypertensives, antidepressants ...
... sensing the body); input-processing (seeing meaning); emotions; memory; time sense; sense of identity; evaluation and cognitive ... Some altered states occur naturally; others can be produced by drugs or brain damage.[126] Altered states can be accompanied by ... Antonio Damasio (1999). The Feeling of What Happens: Body and Emotion in the Making of Consciousness. New York: Harcourt Press ... He proposed that we speak not of minds, bodies, and the world, but of individuals, or persons, acting in the world. Thus, by ...
U.S. Food and Drug Administration. 30 August 2017. Research, Center for Drug Evaluation and. "FDA approves axicabtagene ... Prosthetic gene therapy aims to enable cells of the body to take over functions they physiologically do not carry out. One ... Food and Drug Administration. Center for Biologics Evaluation and Research. Guidance for Industry: Guidance for Human Somatic ... Since that time, drugs such as Novartis' Zolgensma and Alnylam's Patisiran have also received FDA approval, in addition to ...
Forensic toxicology is the study of the effect of drugs and poisons on/in the human body. Forensic video analysis is the ... Periodic evaluations of a lab's performance by an independent organization will help to prevent scandals from occurring in ... When the dead body of Culshaw was examined, a pistol wad (crushed paper used to secure powder and balls in the muzzle) found in ... He created the Bertillon System around 1879, a way of identifying criminals and citizens by measuring 20 parts of the body. In ...
... is the most widely used health-related quality of life questionnaire in health economic evaluations. EQ-5D can be used to ... EQ-5D is recommended by many health technology assessment (HTA) bodies internationally as a key component of cost-utility ... to assist in providing evidence about effectiveness in processes where drugs or procedures require approval. ... The MVH value set became widely applied in economic evaluations in the UK and other countries, and continues to be used today. ...
Drug Delivery: drugs can be incorporated into the microbubble's lipid shell. The microbubble's large size relative to other ... Ultrasound imaging allows real-time evaluation of blood flow.[20]. *Destruction of microbubbles by ultrasound[21] in the image ... The body is 73% water, and therefore, acoustically homogeneous. Blood and surrounding tissues have similar echogenicities, so ... drug delivery vehicles like liposomes may allow a greater amount of drug to be delivered per vehicle. By targeted the drug- ...
National Institute of Food and Drug Safety Evaluation[edit]. National Institute of Food and Drug Safety Evaluation (NIFDS)[27] ... "Ministry of Food and Drug Safety". Korea Food and Drug A.. *^ "IFOAM Accredited Certification Bodies" (PDF). International ... "National Institute of Food and Drug Safety Evaluation". Korea: National Institute of Food and Drug Safety Evaluation.. ... Food and Drug Administration (2017-10-05). "Part I: The 1906 Food and Drugs Act and Its Enforcement". Food and Drug ...
... with the main sections on drugs and preparations being organised by body system. Table of Contents Preface Acknowledgements How ... Advice is constructed from clinical literature, and reflects, as far as possible, an evaluation of the evidence from diverse ... prescribing Prescription writing Emergency supply of medicines Controlled drugs and drug dependence Adverse reactions to drugs ... which comprises representatives of the two professional bodies, and the Department of Health (DoH). Information on drugs is ...
Key factors in this evaluation are the patient's age, body mass index, medical and surgical history, current medications, and ... The first drug used for this purpose was curare, introduced in the 1940s, which has now been superseded by drugs with fewer ... A variety of drugs may be administered, with the overall aim of ensuring unconsciousness, amnesia, analgesia, loss of reflexes ... The patient presses a button to activate a syringe device and receive a preset dose or "bolus" of the drug, usually a strong ...
Vogel, Hans (2008). Drug Discovery and Evaluation: Pharmacological Assays (3 ed.). pp. 9-10. ISBN 978-3-540-70995-4. Bennett, ... Goldberg, Jeff (2013). Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine. Skyhorse Publishing. ISBN ... For studying the effects of drugs on receptors in drug discovery and combinatorial chemistry, novel techniques such as high ... This in turn allows the quantification of a drug's pharmacological profile in the tissue in question, such as the calculation ...
Janet Woodcock, director of the FDA's Center for Drug Evaluation and Research, overruled the panel, and FDA Commissioner Robert ... and the presence of altered dystrophin in the body. On April 25, 2016, the Advisory Committee Panel voted against approval;. ... New Drug Applications (NDA) for eteplirsen and a similar drug drisapersen were filed with the US Food and Drug Administration ( ... The Prescription Drug User Fee Act (PDUFA) goal dates for these were December 27, 2015 for drisapersen and February 26, 2016 ...
Forensic toxicology - the study of the effect of drugs and poisons on the human body. Trace evidence analysis is the analysis ... Forensic serology - study of the body fluids. Forensic video analysis - scientific examination, comparison, and evaluation of ... History of autopsies - Autopsies that opened the body to determine the cause of death were attested at least in the early third ... History of dissection - Roman law forbade dissection and autopsy of the human body, so physicians such as Galen were unable to ...
It has since been the gold standard for pharmacodynamic studies in diabetes drug development and diagnostics evaluation. In ... When the steady-state is achieved, the glucose infusion rate equals glucose uptake by all the tissues in the body and is ...
The effects of the antimalarial drugs, however, will require further evaluation before being clinically exploited. Grapefruit ... Such enzymes present in the GI tract are a first line defense against toxic substances; this allows the body to metabolize away ... The effects of these drugs, however, will require further evaluation before being clinically exploited.[citation needed] ... but when they are taken concurrently with antiretroviral drugs they enhance the effect of that drug. One of these is an over- ...
Designed by Mikyoung Kim, the garden was "built upon a growing body of scientific research which links access to natural light ... Design for Aging: Post-Occupancy Evaluations, American Institute of Architects Healing Gardens: Therapeutic Benefits and Design ... Therapeutic dementia gardens are used to reduce the symptoms of the disorder without the use of drugs. ... Healing Landscapes: Therapeutic Outdoor Environments, Martha Tyson The Healing Landscape: Gardening for the Mind, Body, and ...
"National Institute of Food and Drug Safety Evaluation". Korea: National Institute of Food and Drug Safety Evaluation. "Taiwan ... accredited certification bodies 2) Government accredited certification bodies - 328 bodies in 29 countries have been registered ... Food and Drug Administration (5 October 2017). "Part I: The 1906 Food and Drugs Act and Its Enforcement". Food and Drug ... National Institute of Food and Drug Safety Evaluation (NIFDS) is functioning as well. The National Institute of Food and Drug ...
He also planted the bomb under the chair during his interrogation and used the distraction to hide Lewis's body. Just as Damien ... Brody confronts the person, only to be stabbed to death and dragged away. After Chuck and Director Jane Bentley (Robin Givens) ... Chuck tasks John Casey with the candidates' physical testing, Sarah Walker with psychological evaluations, and Morgan Grimes ... However, they find Lewis's body, with his throat slit. Chuck, Casey, and Sarah to confront Bentley and Josie, the only ...
In this case, a drug holiday would be of no benefit. The use of these are based on the clinical evaluation of the condition and ... to the same risk as patients who have never taken the drugs because anti-angiogenic drugs do not normally reside in the body ... The main groups of drugs involved are anti-resorptive drugs, and anti-angiogenic drugs. This condition was previously known as ... In this case, a drug holiday would be of no benefit. For some patients, it is possible to have a drug holiday during which ...
But an excess of vasopressin is counterproductive in a body retaining too much fluid. The drug shows promise in treating heart ... Treatment of HyponatrEmia BAsed on LixivAptan in N Yha class III/IV Cardiac patient Evaluation) study. THE BALANCE study is a ... When the body needs to remain hydrated under certain conditions, vasopressin can have protective effects. ... As a fundamental part of hormonal control in the body, it is implicated in many different conditions. Vaptans can be ...
Photosafety evaluation[edit]. Physico-chemical properties[edit]. In vitro test systems[edit]. 3T3 Neutral Red Phototoxicity ... During drug development[edit]. Several health authorities have issued related guidance documents, which need to be considered ... Porphyrins, a class of natural molecules occurring in the body and accumulating in patients with certain genetic defects in the ... Many synthetic compounds, including drug substances like tetracyclines or fluoroquinolones, are known to cause these effects. ...
Hypothyroidism is a state in which the body is not producing enough thyroid hormones, or is not able to respond to / utilize ... Free T4 levels should be measured in the evaluation of hypothyroidism, and low free T4 establishes the diagnosis. T3 levels are ... Hyperthyroidism caused by Graves' disease may be treated with the thioamide drugs propylthiouracil, carbimazole or methimazole ... Hyperthyroidism is a state in which the body is producing too much thyroid hormone. The main hyperthyroid conditions are: * ...
... aerodynamic tests were part of the early evaluations. Thus, the body was of novel design and, with safety in mind, it provided ... Because the car had to have a very low drag coefficient,0.3, which even today is considered very impressive, ... By summer 1946 the first prototype body was ready, hand beaten on a wooden jig. Shaping of the metal was done in Saab's secret ... Since this was not viable on an automobile, it was decided that the body structure should be strengthened through the use of a ...
... and that drug C is known to reduce the amount of chemical B in the body. However, because the respective articles were ... The evaluation of literature-based discoveries is challenging, and includes both experimental and in silico methods. Swanson ... published separately from one another (called "disjoint data"), the relationship between illness A and drug C may be unknown. ...
"Alcohol and Drug Abuse Prevention and Treatment (ADAPT)". USAF's David Grant USAF Medical Center. Archived from the original on ... One drink per hour is approximately the amount the body can metabolize. Three drinks per night was selected as a target below ... Based on evaluation results individuals were provided educational and motivational enhancement interventions, or if found to ... "Enforcing Underage Drinking Laws through Community/USAF Base Coalitions: Evaluation Findings" (PDF). ICF International. ...
The evaluation of a child suspected to have craniosynostosis is preferentially performed in a craniofacial center. The three ... Syndromal craniosynostosis presents with a skull deformity as well as deformities affecting other parts of the body.[42] ... Environmental factors refer for example to maternal smoking and the maternal exposure to amine-containing drugs. Several ... Cunningham ML, Heike CL (December 2007). "Evaluation of the infant with an abnormal skull shape". Current Opinion in Pediatrics ...
"Evaluation of EPA's Pesticide Import Inspections Project No. OPE -FY16 -00 25" (PDF). The Office of Inspector General (OIG) for ... Under Section 408 of the Federal Food, Drug, and Cosmetic Act (FFDCA), the EPA can also regulate the amount of pesticide ... either into or in contact with the bloodstream or normally sterile areas of the body and the term "semi-critical device" ... any nitrogen stabilizer, except that the term "pesticide" shall not include any article that is a "new animal drug" within the ...
Izzedine H, Launay-Vacher V, Deybach C, Bourry E, Barrou B, Deray G (November 2005). "Drug-induced diabetes mellitus". Expert ... The body mass index cutoffs for when surgery is appropriate are not yet clear.[122] It is recommended that this option be ... a systematic review and economic evaluation". Health Technology Assessment. 13 (41): 1-190, 215-357, iii-iv. doi:10.3310/ ... Krentz AJ, Bailey CJ (February 2005). "Oral antidiabetic agents: current role in type 2 diabetes mellitus". Drugs. 65 (3): 385- ...
Patients often express interest in mind-body complementary therapies because they offer a non-drug approach to treating some ... General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine (PDF). WHO/EDM/TRM/2001.1. Geneva: ... De Smet, Peter A.G.M. (December 1997). "The Role of Plant-Derived Drugs and Herbal Medicines in Healthcare". Drugs. 54 (6): 801 ... Mind-body interventions: Explore the interconnection between the mind, body, and spirit, under the premise that they affect " ...
"U.S. Food and Drug Administration (FDA).. *Ebola: What You Need to Know - Scientific American articles related to Ebola; note ... Ebola can stay in some body parts like the eyes,[143] breasts, and testicles after infection.[4][144] Sexual transmission after ... "Guidelines for Evaluation of US Patients Suspected of Having Ebola Virus Disease". Centers for Disease Control and Prevention ( ... "U.S. Food and Drug Administration (FDA) (Press release). 14 October 2020. Retrieved 14 October 2020.. This article incorporates ...
"Drug Trials Snapshots: Aklief". U.S. Food and Drug Administration (FDA). 11 October 2019. Archived from the original on 19 ... "The Body Project: An Intimate History of American Girls. Knopf Doubleday Publishing Group. pp. 57-94. ISBN 9780307755742. . ... Pregnancy category refers to an evaluation of a substance's risk of injury to a fetus if used by the mother during pregnancy.[ ... Aslam I, Fleischer A, Feldman S (March 2015). "Emerging drugs for the treatment of acne". Expert Opinion on Emerging Drugs. 20 ...
Foreign bodies (such as fingers during nose-picking). *Inflammatory reaction (e.g. acute respiratory tract infections, chronic ... Drugs-aspirin, fexofenadine, warfarin, clopidogrel, prasugrel, isotretinoin, desmopressin and others. *Envenomation by mambas, ... Ongoing bleeding despite good nasal packing is a surgical emergency and can be treated by endoscopic evaluation of the nasal ... The drugs oxymetazoline or phenylephrine are widely available in over-the-counter nasal sprays for the treatment of allergic ...
Some species differ in form from the typical octopus body shape. Members of the suborder Cirrina have stout gelatinous bodies ... Derby, C. D. (2014). "Cephalopod Ink: Production, Chemistry, Functions and Applications". Marine Drugs. 12 (5): 2700-2730. doi: ... "Interspecific Evaluation of Octopus Escape Behavior" (PDF). Journal of Applied Animal Welfare Science. Lawrence Erlbaum ... This moves the body slowly.[31]. In 2005, Adopus aculeatus and veined octopus (Amphioctopus marginatus) were found to walk on ...
"Synthroid (Levothyroxine Sodium) Drug Information: Uses, Side Effects, Drug Interactions and Warnings". RxList. Archived from ... Dosages vary according to the age groups and the individual condition of the person, body weight and compliance to the ... further laboratory and clinical evaluation is warranted as they may have another cause for their symptoms.[11] Furthermore, it ... "International Drug Price Indicator Guide. Retrieved 8 December 2016.. *^ Hamilton, Richart (2015). Tarascon Pocket ...
... but also human body parts and fluids.[57] Pharmacology developed in part from herbalism and some drugs are still derived from ... A knowledge of biostatistics is essential in the planning, evaluation, and interpretation of medical research. It is also ... to the body, which can then be imaged outside the body by a gamma camera or a PET scanner. Each radiopharmaceutical consists of ... Diagnostic radiology is concerned with imaging of the body, e.g. by x-rays, x-ray computed tomography, ultrasonography, and ...
One hypothesis is that they are a learned physical reaction or habit the body develops, similar to a reflex. The individual ... Caution that anticonvulsant drug withdrawal should be done in conjunction with their physician ... or other important areas of functioning or warrants medical evaluation. ... This therapy focuses on the idea that PNES are caused by a learned physical reaction or habit the body develops, similar to a ...
Administrative bodies,. courts Prisons Clinics Asylums Schools,. youth. houses,. kindergartens High. schools Gymnasiums,. ... Ireland's Office of Tobacco Control website indicates that "an evaluation of the official hospitality sector data shows there ... Drug Testing and Analysis. 11 (1): 140-156. doi:10.1002/dta.2471. hdl:10072/382912. PMID 30109771.. ... Drug and Alcohol Review. 37 (7): 912-921. doi:10.1111/dar.12848. PMID 30051520.. ...
"Infection and Drug Resistance. 8: 119-128. doi:10.2147/IDR.S66739. PMC 4440423. PMID 26028977.. ... In 10-20% of untreated cases, EM rashes develop at sites across the body that bear no relation to the original tick bite.[23] ... The CDC is currently conducting research on evaluation and diagnostics of the disease and preliminary results suggest the ... The EM (Erythema migrans) rash is often accompanied by symptoms of a viral-like illness, including fatigue, headache, body ...
Ernst E (May 2008). "Chiropractic: a critical evaluation". Journal of Pain and Symptom Management. 35 (5): 544-62. doi:10.1016/ ... Palmer hypothesized that vertebral joint misalignments, which he termed vertebral subluxations, interfered with the body's ... American chiropractors found that a slight majority favored allowing them to write prescriptions for over-the-counter drugs.[37 ... I do, however, refer to such evaluations and should add that a report recently commissioned by the General Chiropractic Council ...
U.S. Food and Drug Administration. Retrieved 2010-10-15.. *^ "Title 21-Food and drugs: Chapter i-Food and drug administration: ... it must be verified by a Certificate of Conformity issued by a Notified Body. A Notified Body is a public or private ... "11.100.20: Biological evaluation of medical devices". Retrieved 10 April 2009.. *^ International Organization for ... U.S. Food and Drug Administration. Retrieved 2010-10-15.. *^ a b c d e f "General and Special Controls". Medical Devices. U.S. ...
Androgen receptor antagonists: drugs that bind directly to and block the AR.[57][58] These drugs include the steroidal ... However, because estrogens are made from androgens in the body, antiandrogens that suppress androgen production can cause low ... IARC Working Group on the Evaluation of Carcinogenic Risks to Humans; World Health Organization; International Agency for ... Drug class. Bicalutamide, a nonsteroidal antiandrogen and the most widely used androgen receptor antagonist in the treatment of ...
The bodies were picked over by vultures and dragged away by jackals. Sometimes this happened while the victim was still living. ... Dyson, Tim; Maharatna, Arup (September 1991). "Excess mortality during the Great Bengal Famine: A Re-evaluation". The Indian ... People would tie a rope around the necks and drag them over to a ditch."[249] Corpses were stacked along the streets of ... Advanced anti-malarial drugs such as mepacrine (Atabrine) were distributed almost solely to the military and to "priority ...
Adkins, J.A., Kelley, S.D., Bickman, L., & Weiss, H.M. (2011). Program evaluation: The bottom line in organizational health. In ... Musculoskeletal disorders (MSDs) involve injury and pain to the joints and muscles of the body. Approximately 2.5 million ... Dewe, P.J. (1989). Examining the nature of work stress: Individual evaluations of stressful experiences and coping. Human ... Differential associations of job control components with both waist circumference and body mass index. Social Science & ...
2002). "Evaluation of ultra-high temperature ceramics for aeropropulsion use". Journal of the European Ceramic Society. 22 (14- ... Vehicles with "sharp" leading edges have significantly higher lift to drag ratios, enhancing the fuel efficiency of sustained ... bodies and hypersonic air-breathing vehicles such as scramjets and DARPA's HTV because the bow shock in front of a blunt body ... Sharp edges dramatically reduce drag, but the current generation of thermal protection system materials are unable to withstand ...
For many individuals, these may require a minimum duration of psychological evaluation and living as a member of the target ... Further in the future, stem cell biotechnology may also make this possible, with no need for anti-rejection drugs. ... In consequence, transsexuals individuals who have undergone SRS are more satisfied with their bodies and experienced less ... may eventually make childbearing possible by using a donor uterus long enough to carry a child to term as anti-rejection drugs ...
... is a controlled drug for the purpose of the Misuse of Drugs Act 1977 and Schedule 1 of the Misuse of Drugs Regulations ... "British-Yemeni Society: The impact of khat-chewing on health: a re-evaluation". Al-bab.com. Archived from the original on 7 ... the body to recycle these neurotransmitters more slowly, resulting in the wakefulness and insomnia associated with khat use.[32 ... Khat drug profile The European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) ...
The change from a body plan for breathing and navigating in water to a body plan enabling the animal to move on land is one of ... the hind part dragging behind. Finally, Tiktaalik fin bones are somewhat similar to the limb bones of tetrapods.[34][35] ... "The origin of modern amphibians: a re-evaluation". Zoological Journal of the Linnean Society. 162 (2): 457-469. doi:10.1111/j. ... Shubin, N. (2008). Your Inner Fish: A Journey Into the 3.5-Billion-Year History of the Human Body. New York: Pantheon Books. ...
"Drugs.com. 3 January 2018. Retrieved 5 January 2018.. *^ O'Toole, S.; Mullan, F. (2018). "The role of the diet in tooth wear" ( ... Naithani, V; Kakkar, P (2005). "Evaluation of heavy metals in Indian herbal teas". Bulletin of Environmental Contamination and ... and the Chinese drink it to cool down the body when it has become overheated due to weather or sickness. ... Naithani, V; Kakkar, P (2004). "An evaluation of residual organochlorine pesticides in popular Indian herbal teas". Archives of ...
Set-Point malfunction is another theory proposed and supported by Holtorf, which suggests that the body is programmed to return ... Nonsteroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants. In contrast, Dr Holtorf advocates a controversial six step ... "American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of ... to reduce the body's set-point. "Kent Holtorf." The Huffington Post. Retrieved 2011-09-28. Wilson, Lori (2008). "Dr. Kent ...
Lack of facial expressions, mimics, or body gestures/responses. *Non-verbal gestures that could imply the visually impaired ... Lehman, SS (September 2012). "Cortical visual impairment in children: identification, evaluation and diagnosis". Current ... become blind from incorrect diagnosis and from ineffectual prescription of drugs, antibiotics or steroids.[45] In addition, ...
PML body. • cytoskeleton. • nucleoplasm. • microtubule organizing center. • nuclear chromosome. • mitochondrial matrix. • ... response to drug. • DNA unwinding involved in DNA replication. • cellular response to hydroxyurea. • replication-born double- ... Evaluation method. Ref.. Breast cancer (invasive ductal). Over-expression. -. Immunohistochemistry. [12]. Breast cancer (BRCA1 ... "Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer ...
肥胖指的是體脂肪過度堆積而對健康造成負面影響的身體狀態[8]:6。肥胖最初的定義以身體質量指數(Body Mass Index, BMI)為指標,之後也加入了其他標準,例如評估腰臀比或其他心血管病症風險因子[20][21]:14。BMI與體脂肪率和體脂肪 ... Lorcaserin: drug profile and illustrative model of the regulatory challenges of weight-loss drug development. Expert review of ... Clinical Guidelines on the Identification
... including the anticoagulant drug warfarin[40] and the cardiovascular drug nifedipine.[2] ... "body" (describing the shape of its root), but that may be folk etymology.[6] The word probably was readopted in Middle English ... "An Evaluation of Several Mulch Materials on Landscape Plant Growth, Weed Control, Soil Temperature and Soil Moisture : Interim ... Spinella M (2001). The Psychopharmacology of Herbal Medications: Plant Drugs That Alter Mind, Brain, and Behavior. MIT Press. ...
... including chemotherapy drugs, is another potential occupational risk. These drugs can cause cancer and other health conditions. ... Additional evaluation for TB disease as needed (e.g. chest x-ray for HCP with a positive TB test)[31] ... "Personal protective equipment for preventing highly infectious diseases due to exposure to contaminated body fluids in ... a TB symptom evaluation for at least those listed on the Signs & Symptoms page[33] ...
Bennett Alan Weinberg; Bonnie K. Bealer (2001). The World of Caffeine: The Science and Culture of the World's Most Popular Drug ... A number of bodies independently certify the production of tea. Tea from certified estates can be sold with a certification ... critical quantitative evaluation of the pharmacokinetic data in humans after consumption of single doses of beverages". Mol ... Bennett Alan Weinberg, Bonnie K. Bealer (2001). The World of Caffeine: The Science and Culture of the World's Most Popular Drug ...
... allowing them to measure the effects of drugs on different parts of the body. ... MIT engineers have developed new technology that could be used to evaluate new drugs and detect possible side effects before ... Body on a chip could improve drug evaluation Human tissue samples linked by microfluidic channels replicate interactions of ... Body on a chip could improve drug evaluation. Massachusetts Institute of Technology ...
... was developed to evaluate new drugs and detect possible side effects on several organs before human tests. ... Body on a chip may help drug evaluation by replicating multiple organs. By Allen Cone ... March 14 (UPI) -- Computer technology -- known as a "body on a chip -- has been developed to evaluate new drugs and detect ... In this process, they could measure where the drug went, its effects on different tissues and how the drug was broken down. ...
MIT engineers have developed new technology that could be used to evaluate new drugs and detect possible side effects before ... the drugs are tested in humans. Using a microfluidic platform that ... Home pagePress monitoringBody on a chip could improve drug evaluation Body on a chip could improve drug evaluation. Date: 21.3. ... allowing them to measure the effects of drugs on different parts of the body. ...
... ... 6Molecular and Genetic Imaging Core/Taiwan Mouse Clinic, National Comprehensive Mouse Phenotyping and Drug Testing Center, ... imaging and quantitative whole-body autoradiography (QWBAR) with [18F]FDOPA. The images were applied for the measurement of ... we accessed side effects of recreational drugs such as ketamine, cocaine, and methamphetamine on dopamine neurons in peripheral ...
... could improve drug evaluation - Human tissue samples linked by microfluidic channels replicate interactions of multiple organs. ... They could measure where the drugs went, the effects of the drugs on different tissues, and how the drugs were broken down. In ... When developing a new drug, researchers identify drug targets based on what they know about the biology of the disease and then ... and other drugs they may be taking. "A lot of the time you dont see problems with a drug, particularly something that might be ...
Experimental: Adiponectin evaluation Patients evaluated for serum adiponectin level and for body composition before each ... Drug: Tocilizumab Phase 4 Detailed Description:. Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with ... Evolution of Adipokines and Body Composition in Rheumatoid Arthritis Patients Receiving Tocilizumab Therapy (ADIPRAT). The ... Patients with RA also exhibit body composition changes, including an increase in abdominal visceral fat. The impact of ...
Body on a chip could improve drug evaluation. MIT engineers have developed new technology that could be used to evaluate new ... Drug. A drug, broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily ... Identifying designer drugs taken by overdose patients. Drug overdoses are taking a huge toll on public health, with potent ... Some drugs can cause addiction and habituation.. Drugs are usually distinguished from endogenous biochemicals by being ...
Apoptotic bodies (ApoBDs) are membrane-bound extracellular vesicles that can mediate intercellular communication in ... Evaluation of cell surface reactive immuno-adjuvant in combination with immunogenic cell death inducing drug for in situ chemo- ... Wickman, G., Julian, L. & Olson, M. F. How apoptotic cells aid in the removal of their own cold dead bodies. Cell Death Differ ... Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting. *Georgia K. Atkin-Smith1. na1, ...
Message Body (Your Name) thought you would like to see the Circulation web site. ...
Message Body (Your Name) thought you would like to see the Hypertension web site. ... Evaluation of arterial compliance-pressure curves. Effect of antihypertensive drugs.. F Perret, V Mooser, D Hayoz, Y Tardy, J J ... Evaluation of arterial compliance-pressure curves. Effect of antihypertensive drugs.. F Perret, V Mooser, D Hayoz, Y Tardy, J J ... Evaluation of arterial compliance-pressure curves. Effect of antihypertensive drugs.. F Perret, V Mooser, D Hayoz, Y Tardy, J J ...
DARPA-funded body on a chip microfluidic system could revolutionize drug evaluation. Linked by microfluidic channels, compact ... MIT bioengineers have developed a new microfluidic platform technology that could be used to evaluate new drugs and detect ... it can accurately replicate human-organ interactions for weeks at a time and can allow for measuring the effects of drugs on ... possible side effects before the drugs are tested in humans. The microfluidic platform can connect 3D tissues from up to 10 ...
... may be a better predictor of drug dosage than either total bodyweight (TBW) or body surface area (BSA), although the rationale ... There is mounting evidence to suggest that lean body mass (LBM) ... Evaluation of infusion regimens for thiopentone as a primary ... Lean Body Mass as a Predictor of Drug Dosage. Implications for Drug Therapy ... Woodhouse K. Drugs and the liver. Part III: ageing of the liver and the metabolism of drugs. Biopharmaceutics and Drug ...
Intake of any drugs to treat serious acute disease within 1 month before the beginning of the study and within 5 days of each ... Clinical Evaluation of the Accuracy of Vitastiq Device for Tracking Vitamin and Mineral Trend in Human Body (VITASTIQ). The ... Clinical Evaluation of the Accuracy of Vitastiq Device for Tracking Vitamin and Mineral Trend in Human Body. ... A body mass index (BMI) between 18 and 28 kg/m2. *Healthy, meaning absence of any chronic or acute medical therapy for a month ...
The claims of eight cisplatin analogues as viable alternatives to the parent drug are discussed in terms of their toxicities, ... Body Weight / drug effects * Carboplatin * Cisplatin / therapeutic use * Cisplatin / toxicity* * Drug Evaluation, Preclinical ... The claims of eight cisplatin analogues as viable alternatives to the parent drug are discussed in terms of their toxicities, ... had the features most desirable to merit its clinical evaluation. ...
Our Lexapro Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects ... low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling ... Other Reactions Observed During The Premarketing Evaluation Of Lexapro. Following is a list of treatment-emergent adverse ... home drugs a-z list Lexapro(Escitalopram Oxalate) side effects drug center ...
This eBriefing explores common hurdles and pathways to improving pre-clinical model systems for the evaluation of therapeutic ... Accurate measurement of body weight and food intake in environmentally enriched male Wistar rats. Obesity (Silver Spring) 2011; ... Evaluation of Alternative Omic Approaches and Technologies. Thomas Hartung (Johns Hopkins University Center for Alternatives to ... For example, if drug developers want to find new antipsychotic agents, it is not obvious what effect those drugs should have on ...
In terms of annual drug acquisition costs among the non-insulin regimes for a representative patient with a body mass index of ... This report aims to provide information on new drug developments to support a new drugs update to the 2008 guideline. ... the US Food and Drug Administration, the European Medicines Evaluation Agency and the Medicines and Healthcare Products ... Newer agents for blood glucose control in type 2 diabetes: systematic review and economic evaluation Health Technol Assess. ...
Body Weight. Breast Feeding. Drug Evaluation. Female. Humans. Lactation Disorders / drug therapy*. Metoclopramide / therapeutic ...
Body Weight. Signs and Symptoms. Anesthetics. Central Nervous System Depressants. Physiological Effects of Drugs. ... Evaluation. *Time to 97% saturation [ Time Frame: Evaluation of the time needed to the beginning of the ventilation to the ... EPO2-A: Evaluation of Pre-Oxygenation in Morbid Obesity: Effect of Position and Positive Pressure Ventilation (EPO2-A). The ... Evaluation of the changes in vital signs during and after the pre-oxygenation phase in the two combinations of position and ...
State Bar of Michigan Marijuana Law Section presents Drug Evaluation and Classification Course - Friday, May 8, 2020 , Saturday ... and body temperature); Seven drug categories; Drug combinations; Analysis of the drug evaluation narrative report and the drug ... Overview of physiology of drugs; The drug evaluation and classification procedures (12 step process); Drug evaluation eye ... This seminar will cover the key evaluation principles found in the NHTSA Drug Evaluation and Classification Program (DECP-DRE) ...
15 mg per kilogram body weight (maximum 1g)]. ... Drug: Moxifloxacin Drug: Clofazimine Drug: Ethambutol Drug: ... Pyrazinamide Drug: Isoniazid Drug: Prothionamide Drug: Kanamycin Drug: Levofloxacin Drug: Bedaquiline Phase 3 ... The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB (STREAM). The safety and ... STREAM: The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB. ...
Body Weight / drug effects. Cadmium / analysis. Copper / analysis. Environmental Monitoring / methods*. Environmental Pollution ... The nutritional status was estimated from the body mass index; the relationships between this index and metal concentrations ... as body weight was considered a poor indicator of age because of the strong interindividual overlap in the populations. Age was ... which can be attributed to the weight-specific metabolic rate that leads to a relatively low uptake of metals per unit of body ...
Sibutramine (Sibutramine hydrochloride monohydrate) is an anti-obesity drug that enhances satiety. The effect of grapefruit ... juice and sibutramine on body weight and neurotransmitters controlling appetite was investigated in obese rats. Rats were ... Paget GE, Barnes JM (1964). Evaluation of Drug Activities. In: Lawrence DR, Bacharach AL (Eds.), Pharmacometrics Vol. 1. ... No significant change of body weight gain was observed after the third week of drug administration, as compared to obese ...
... having not been on long-term drug regimen;(vi)must be within normal body mass index;(vii)with no trace of underlying causes. ... having not been on long-term drug regimen;(vi)must be within normal range body mass index;(vii)being with no trace of ... O. M. Alhamami, J. Y. AL-Mayah, N. R. AL-Mousawi, and H. I. AL-Mousawi, "Pleiotropic effects of antihypertensive drugs," The ... D. R. J. Singer and A. Kite, "Management of hypertension in peripheral arterial disease: does the choice of drugs matter?" ...
UCB has announced a supplemental new drug application for the companys newest anti-epileptic drug Briviact CV oral ... Body on a chip could improve drug evaluation. By Dr Zara Kassam (European Pharmaceutical Review) ... UCB has announced that the US Food and Drug Administration (FDA) has approved a supplemental new drug application (sNDA) for ... Immunotherapy drug could boost hormone treatment for prostate cancer. By Dr Zara Kassam (European Pharmaceutical Review) ...
Weve written about a bunch of different drug ferrying nanoparticles that scientists around the world have been developing. The ... Enhance prioritization evaluation through streamlined decision making. *Enable innovation through improvements to portfolio ... Self-Powered Rocket Nanovesicles to Ferry Drugs Around Body Able to Open and Close Using External Magnets. September 25th, 2014 ... First Drug-Free Option for ADHD Cleared in America. The Power of Modern Hearing Aids: Interview with Laurel Christensen, Chief ...
Drug statutory and application requirement. Drug application submission. Regulatory procedures, evaluation and veterinary drug ... Pharmacological modulation of organ and body functions. Molecular basis of action and pharmacological effects of ... Drug statutory and application requirement. Drug application submission. Regulatory procedures, evaluation and veterinary drug ... specialised drug therapy pertaining to relevant species and/or organ systems; drug use control and adverse drug reactions. ...
No drug-related effects were observed on body-weight gain, food consumption, or pathological findings. The NOEL was 300 mg/kg ... Cerniglia, C.E. & Kotarski, S. (1999) Evaluation of veterinary drug residues in food for their potential to affect human ... INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY WORLD HEALTH ORGANIZATION TOXICOLOGICAL EVALUATION OF CERTAIN VETERINARY DRUG ... undated) Investigational New Drug/New drug Application data, III Lincocin: Serum and tissue level studies, pp. 29-141. ...
9:50 Notified Bodies and Article 117. Jonathan Sutch, Medicinal Specialist, BSI Group. View Bio. Dr Jonathan Sutch is a ... Challenges in developing injectable platforms for novel drug products. *Case studies leveraging platforms for parenteral drugs ... Injectable Drug Delivery (Virtual Conference). 12th May to 13th May 2021, Online Virtual Event , United Kingdom. ... How an end-to-end approach to drug product control, acceptable PQS and an appropriate risk profile can minimize the need for ...
A program called Fintepla Risk Evaluation and Mitigation Strategies (REMS) program. You, your doctor, and your pharmacy must be ... Your doctor will order certain tests to check your bodys response to fenfluramine. ... If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administrations (FDA) ... You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the ...
  • These chips could also be used to evaluate antibody drugs and other immunotherapies, which are difficult to test thoroughly in animals because they are designed to interact with the human immune system. (eurekalert.org)
  • The process can accurately replicate human organ interactions over several weeks, the MIT researchers said, which could aid in the evaluation of antibody drugs and other immunotherapies. (upi.com)
  • Complications can also arise due to variability among individual patients, including their genetic background, environmental influences, lifestyles, and other drugs they may be taking. (eurekalert.org)
  • Patients with RA also exhibit body composition changes, including an increase in abdominal visceral fat. (clinicaltrials.gov)
  • The impact of tocilizumab therapy in RA patients on adipokines and body composition is not known. (clinicaltrials.gov)
  • A good correlation between drug clearance and LBM indicates that LBM may be an accurate predictor of maintenance dosage, especially in obese patients, in whom there is a large discrepancy between LBM and TBW. (springer.com)
  • UCB has announced that the US Food and Drug Administration (FDA) has approved a supplemental new drug application (sNDA) for the company's newest anti-epileptic drug (AED) Briviact (brivaracetam) CV oral formulations indicated as monotherapy and adjunctive therapy in the treatment of partial onset (focal) seizures in patients age four years and older. (europeanpharmaceuticalreview.com)
  • Some minor drug interactions may not be clinically relevant in all patients. (drugs.com)
  • Patients who develop symptoms should have a detailed cardiac evaluation and if needed, treatment should be suspended. (drugs.com)
  • If a second course of therapy is needed, it can be initiated eight or more weeks after completion of the first course, since experience has shown that patients may continue to improve while off the drug. (rxlist.com)
  • In general, patients initially should receive EPURIS® 0.5 mg/kg body weight daily for a period of two to four weeks, when their responsiveness to the drug will usually be apparent. (rxlist.com)
  • For many adult patients with a blood disorder, treatment options have been limited because they are often not sick enough to qualify for a risky procedure, or they are too sick to tolerate the toxic drugs used alongside a standard transplant," said Damiano Rondelli, Professor at the University of Illinois. (medindia.net)
  • In dehydrated patients, fluid therapy is given to stabilize the body fluids. (petmd.com)
  • Conclusion: More than one-third of postmenopausal women taking long-term bisphosphonate therapy had low fracture risk, and over 40% of our patients were eligble for a drug holiday or discontinuation. (ku.edu)
  • Furthermore, the cost of these drugs may prevent their use in a significant proportion of patients, especially in countries in which the health care system does not cover drug expenses. (diabetesjournals.org)
  • Modern cancer drugs can cost more than €9,250 a month, placing a heavy financial burden on governments, insurers and patients. (euractiv.com)
  • The proposed m-f-PBPK model can be used to predict fetal exposure to drugs across gestational ages and therefore provide the necessary information to assess the risk of drug toxicity to the fetus. (aspetjournals.org)
  • Consequently, the ability to quantitatively evaluate fetal exposure to drugs and risk of toxicity, not only at term but also earlier during pregnancy when the fetus is most vulnerable to teratogens, is needed. (aspetjournals.org)
  • Liver is the chief metabolizing site in the body, and thus, it is a major target organ for drug and chemical toxicity. (wiley.com)
  • This valuable authoritative source of information is the first book to address this topic for nearly ten years, making it an essential resource for readers from a wide range of disciplines such as toxicology, pharmacology, hepatology, drug toxicity and food science. (wiley.com)
  • Using a microfluidic platform that connects engineered tissues from up to 10 organs, the researchers can accurately replicate human organ interactions for weeks at a time, allowing them to measure the effects of drugs on different parts of the body. (eurekalert.org)
  • The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. (drugs.com)
  • Minor drug interactions do not usually cause harm or require a change in therapy. (drugs.com)
  • If you are taking this product under your doctor's direction, your doctor or pharmacist may already be aware of possible drug interactions and may be monitoring you for them. (medhelp.org)
  • Projecting ADME Behavior and Drug-Drug Interactions in Early Discovery and Development: Application of the Extended Clearance Classification System. (nih.gov)
  • Full drug pipelines at many companies suggest the strong rate of new drug launches is likely to continue for a while yet, with IMS Health forecasting a total of 225 new drug approvals between 2016 and 2020. (euractiv.com)
  • He asked for a psychiatric evaluation to be done on the man. (drugawareness.org)
  • The court said trial lawyer David Schieck failed to request a psychiatric evaluation prior to advising her to plead guilty. (drugawareness.org)
  • In light of trial counsel's knowledge, he was unreasonable in failing to request a psychiatric evaluation prior to counseling appellant (Snyder) to plead guilty. (drugawareness.org)
  • The court said a psychiatric evaluation may have supported the only line of defense for Snyder of "insanity or that she lacked the requisite state of mind. (drugawareness.org)
  • A medical psychologist who holds prescriptive authority for specific psychiatric medications and other pharmaceutical drugs must first obtain specific qualifications in Psychopharmacology . (wikipedia.org)
  • Evaluation of protective efficacy of CC-2 formulation against topical lethal dose of T-2 toxin in mice. (curehunter.com)
  • America's Health Insurance Plans, a national association representing nearly 1,300 health insurance companies, has proposed a plan to establish a new entity to compare the safety and efficacy of new drugs. (fdanews.com)
  • The rising prevalence of serious fungal infections and antifungal drug resistance has created an increased demand for reliable methods of in vitro testing of antifungal agents that can assist in their clinical use. (asm.org)
  • 1 Current in vitro Models to Study Drug-Induced Liver Injury ( Julio C. Davila, Jinghai J. Xu, Keith A. Hoffmaster, Peter J. O'Brien and Stephen C. Storm ). (wiley.com)
  • 2 Utilization of an in vitro Hepatotoxicity Test in the Early Stage of Drug Discovery ( Ikuo Horii, Hiroshi Yamada, Rie Kikkawa, Toshinori Yamamoto, Tamio Fukushima and Kaori Tomizawa ). (wiley.com)
  • 4 Human-Based in vitro Experimental Systems for the Evaluation of Human Drug Safety ( Albert P. Li ). (wiley.com)
  • SMi is proud to present the 3rd Annual Injectable Drug Delivery Virtual Conference on 12th and 13th May 2021. (smi-online.co.uk)
  • This necessitates individual adjustment of dosage according to the response of the condition and the patient's tolerance of the drug. (rxlist.com)
  • CDA is rare blood disorder in which the patient's body does not produce enough red blood cells and could cause progressive organ damage and early death. (medindia.net)
  • With rapid developments in the parenteral space the injectable drug delivery market is set to reach USD 39.8 billion by 2027, with an increased focus on patient centricity during DDC development, innovations in device development, including and new therapeutic applications including the delivery of siRNA - this year's event will focus on advances in drug product formulation and innovations of device design and development to aid delivery. (smi-online.co.uk)
  • With the aging of the world population, osteoarthritis (OA) is becoming an increasingly common cause of disability [ 1 , 2 ] Diarthrodial joint damage assessment of the knee joint in particular is crucial for monitoring OA disease progression and for eventually evaluating the therapeutic effect of disease modifying osteoarthritis drugs (DMOADs) on its anatomical structure. (biomedcentral.com)
  • 3 Recently, whole-body vibration has been considered to be a possible therapeutic intervention for increasing bone density in the elderly and others at risk for osteoporosis. (ahrq.gov)
  • Thank you for sharing this Drug Metabolism & Disposition article. (aspetjournals.org)
  • Our simulations yielded novel insights into the quantitative contribution of fetoplacental metabolism and/or placental transport on gestational age-dependent fetal drug exposure. (aspetjournals.org)
  • 3 Use of Hepatocytes for Characterizing a Candidate Drug's Metabolism and Drug Interaction Potential ( Srikanth C. Nallani, John M. Strong and Shiew Mei Huang ). (wiley.com)
  • In the presence of PMS, the XTT reagent yielded usable absorbance values for growth and drug sensitivity evaluations with a variety of cell lines. (aacrjournals.org)
  • Through sensitivity analyses, we demonstrated that the UV/MP ratio does not measure the extent of fetal drug exposure unless obtained at steady state after an intravenous infusion or when there is little or no fluctuation in MP drug concentrations after multiple-dose oral administration. (aspetjournals.org)
  • In pharmacology, Dictionary.com defines a drug as "a chemical substance used in the treatment, cure, prevention, or diagnosis of disease or used to otherwise enhance physical or mental well-being. (phys.org)
  • This training seminar is an overview of the key evaluation principles found in the NHTSA Drug Evaluation and Classification Program (DECP-DRE) led by Lance Platt and team-taught with Fran Gengo, PHARM.D. The course will provide a look at pharmacology from the law enforcement and pharmacologist points of view. (eventbrite.com)
  • In terms of annual drug acquisition costs among the non-insulin regimes for a representative patient with a body mass index of around 30 kg/m2, the gliptins were the cheapest of the new drugs, with costs of between 386 pounds and 460 pounds. (nih.gov)
  • Survivors are half as likely to have the cancer return if they keep their Body Mass Index (BMI) below 25," said Gardiner. (healthcanal.com)
  • Data showed [ 13 ] that rapid disease progression might have been predicted at the outset of the study based on certain clinical variables: being female, having a high body mass index (BMI), experiencing a higher level of pain and stiffness, and having reduced joint mobility. (biomedcentral.com)
  • Regular and quality physical education can help children and adolescents achieve the recommended amount of daily vigorous-or moderate-intensity physical activity and improve fitness and potentially body mass index (BMI). (nap.edu)
  • This article reviews studies from the United States that examined the age of menarche and the age of onset of breast development and pubic hair as a function of body mass index, which is a good surrogate measure of body fat. (aappublications.org)
  • However, at least several studies show that girls who have relatively higher body mass index are more likely to have earlier menses, as well as a relationship between body mass index and other measures of pubertal onset. (aappublications.org)
  • Participants will receive a Certification of their mastery of "An Overview of the NHTSA Drug Evaluation and Classification Program (DRE) 2018 Curriculum. (eventbrite.com)
  • Membership in the section is open to all active and associate members of the IACP in good standing who are either certified DREs and other qualified individuals who have a professional interest in the Drug Evaluation and Classification Program or procedures. (theiacp.org)
  • The Drug Evaluation and Classification Program is recognized by all fifty states in the U.S., Canada, Hong Kong, and the United Kingdom. (theiacp.org)
  • Many states have websites containing information specific to their Drug Evaluation and Classification Program. (theiacp.org)
  • The DRE Section prepares an annual report on the activities and accomplishments of the International Drug Evaluation and Classification Program (DECP). (theiacp.org)
  • Drugs may be prescribed for a limited duration, or on a regular basis for chronic disorders. (phys.org)
  • What is the role of receptors throughout the body in the pathophysiology taste and smell disorders? (medscape.com)
  • Medical psychology is the application of psychological principles to the practice of medicine , primarily drug-oriented, for both physical and mental disorders. (wikipedia.org)
  • In a test, researchers successfully delivered a drug to gastrointestinal tissue, mimicking oral ingestion of a drug. (upi.com)
  • One possible intervention is whole-body vibration therapy. (ahrq.gov)
  • Juvenile chronic arthritis can be halted by long-term, intense physical therapy and drugs. (chiro.org)
  • Fortunately, there are workable alternatives to treating chronic pain with drugs: integrative therapies can help and are increasingly being put into practice. (drweil.com)
  • But here's Dr. Bonakdar's bottom line: if you or someone close to you suffers from chronic pain syndrome, insist on an integrative treatment plan and recognize that drugs can't address all the problems chronic pain presents. (drweil.com)
  • MIT engineers have developed new technology that could be used to evaluate new drugs and detect possible side effects before the drugs are tested in humans. (eurekalert.org)
  • March 14 (UPI) -- Computer technology -- known as a "body on a chip -- has been developed to evaluate new drugs and detect possible side effects on several organs before they are tested in humans, according to engineers at the Massachusetts Institute of Technology. (upi.com)
  • Also other factors in humans are their genetic background, environmental influences, lifestyles and other drugs being taken. (upi.com)
  • Drug disposition on obese humans an update. (springer.com)
  • Baecke JAH, Burema T, Deurenberg P. Body fatness, relative weight and frame size in young adults. (springer.com)
  • The relative age of the individuals was estimated on the basis of crystalline lens weight in mice and dental abrasion in shrews, as body weight was considered a poor indicator of age because of the strong interindividual overlap in the populations. (biomedsearch.com)
  • the relationships between this index and metal concentrations for both A. sylvaticus and C. russula were negative, which can be attributed to the weight-specific metabolic rate that leads to a relatively low uptake of metals per unit of body weight. (biomedsearch.com)
  • The effect of grapefruit juice and sibutramine on body weight and neurotransmitters controlling appetite was investigated in obese rats. (academicjournals.org)
  • None of the animals exposed to only T-2 toxin at lethal dose of 2 and 4 LD50 (11.8 and 23.76 mg/kg body weight ) survived beyond 36 and 16 h, respectively. (curehunter.com)
  • Maintenance dose should be adjusted between 0.1 and 1 mg/kg body weight daily and, in exceptional instances, up to 2 mg/kg body weight daily, depending upon individual patient response and tolerance to the drug. (rxlist.com)
  • 100, 200 and 400 mg/kg body weight/day, orally. (mdpi.com)
  • The main factors impacting intoxication level are a person's weight, body composition and hormones, number of drinks, and the span of time the drinks are consumed in. (brown.edu)
  • Evaluation of a Mathematical Model of Rat Body Weight Regulation in Application to Caloric Restriction and Drug Treatment Studies. (nih.gov)
  • 24,34-36 Another hypothesis is that the effect of whole-body vibration is similar to other weight-bearing exercise 37,38 and improves muscle strength and power by increasing neuromuscular activation. (ahrq.gov)
  • Liver weight changes and urobilinogen and ketone bodies in the urine were observed in rats fed 15 mg/kg/day for 28 days. (fluoridealert.org)
  • Frisch, relying heavily on studies involving loss of reproductive function in women after weight loss, later modified her theory to suggest that there is a critical fat mass (∼17% of body weight) required for menarche and a higher fat mass (22% of body weight) needed for maintenance of reproductive capacity. (aappublications.org)
  • Aid Access was sent a letter by the United States Food and Drug Administration (FDA) on March 8, 2019 warning Aidaccess.org to cease selling "a misbranded and unapproved new drug" in the United States. (wikipedia.org)
  • Research, Center for Drug Evaluation and (2019-12-20). (wikipedia.org)
  • For many drugs eliminated predominantly by the liver, there is a good correlation between systemic clearance and LBM. (springer.com)
  • Such a correlation could be due to a correlation between systemic clearance and liver size or liver blood flow, which has been demonstrated for a few drugs, and a correlation between LBM and liver size and blood flow. (springer.com)
  • Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design. (nih.gov)
  • Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1-Transfected Human Embryonic Kidney 293 Cells. (nih.gov)
  • Each drug is provided at two concentrations in dehydrated form and is reconstituted by adding the inoculum suspension in RPMI 1640 medium. (asm.org)
  • A program called Fintepla Risk Evaluation and Mitigation Strategies (REMS) program. (medlineplus.gov)
  • With our chip, you can distribute a drug and then look for the effects on other tissues and measure the exposure and how it is metabolized. (eurekalert.org)
  • The new system, a microfluidic platform that connects engineered tissues from up to 10 organs, can determine whether a drug to treat one organ will affect another one, according to findings published Wednesday in the journal Scientific Reports. (upi.com)
  • In this process, they could measure where the drug went, it's effects on different tissues and how the drug was broken down. (upi.com)
  • Using this system, the researchers showed that they could deliver a drug to the gastrointestinal tissue, mimicking oral ingestion of a drug, and then observe as the drug was transported to other tissues and metabolised. (europeanpharmaceuticalreview.com)
  • If you consume more than this, the additional alcohol will accumulate in the blood and body tissues (like the brain) until it can be metabolized. (brown.edu)
  • Drug overdoses are taking a huge toll on public health, with potent synthetic drugs posing a particular threat. (phys.org)
  • According to the U.S. Centers for Disease Control and Prevention (CDC), more people died from drug overdoses in 2014 (the last year for which we have complete numbers) than in any other year on record. (drweil.com)
  • When developing a new drug, researchers identify drug targets based on what they know about the biology of the disease, and then create compounds that affect those targets. (eurekalert.org)
  • A*STAR researchers have developed nanoscale drug delivery particles that can sense their surroundings, and release their payload only after entering a cell, a discovery that could make many existing medicines more effective. (phys.org)
  • Researchers at Radboud University in The Netherlands have just reported on a new method of manipulating polymersomes to be able to hold onto drugs while providing their own rocket-like propulsion inside the body. (medgadget.com)
  • Such a system could reveal, for example, whether a drug that is intended to treat one organ will have adverse effects on another. (eurekalert.org)
  • As part of a project spearheaded by the Defense Advanced Research Projects Agency (DARPA), Griffith and her colleagues decided to pursue a technology that they call a "physiome on a chip," which they believe could offer a way to model potential drug effects more accurately and rapidly. (eurekalert.org)
  • Here, we accessed side effects of recreational drugs such as ketamine, cocaine, and methamphetamine on dopamine neurons in peripheral organs by using positron emission tomography (PET) imaging and quantitative whole-body autoradiography (QWBAR) with [ 18 F]FDOPA. (hindawi.com)
  • Antihypertensive drugs acting by different mechanisms may have different effects on the mechanical properties of large arteries. (ahajournals.org)
  • Our Lexapro Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • Are these side effects of the drug or is it food poisoning since my main meal was junk food last night? (drugs.com)
  • Anabolic steroid users showed higher body- and fat-free mass indexes, consistent with known effects of anabolic steroids. (eurekalert.org)
  • The drag coefficient of any object comprises the effects of the two basic contributors to fluid dynamic drag: skin friction and form drag. (wikipedia.org)
  • The drag coefficient of a lifting airfoil or hydrofoil also includes the effects of lift-induced drag. (wikipedia.org)
  • The drag coefficient of a complete structure such as an aircraft also includes the effects of interference drag. (wikipedia.org)
  • A person's experience with alcohol's effects on the body is in part determined by their sex assigned at birth. (brown.edu)
  • Please note that if you are taking hormones as part of a gender affirming process, you may find that your experience with alcohol's effects on your body will change but there is not adequate research as yet to describe the full scope and variability of these effects. (brown.edu)
  • Experienced effects indicate the extent to which respondents have actually experienced particular effects of drug use, rather than whether or not they believe that particular outcomes will occur. (europa.eu)
  • You experience mental and physical effects (withdrawal) if you stop taking the drug. (healthline.com)
  • Extracted from the root of a plant native to West Africa, the drug produces psychedelic effects akin to a waking dream and is said by its advocates to spirit away withdrawal symptoms with a single dose, leaving users sober and uninterested in smack. (wired.com)
  • Roughly parallel to America's Food and Drug Administration (FDA), but without FDA-style centralisation, the EMA gets funding from the EU and the pharmaceutical industry, as well as indirect subsidy from member states. (euractiv.com)
  • Another problem: pharmaceutical companies produce vastly more opioid drugs than are needed for legitimate medical use. (drweil.com)
  • This conference provides certified drug recognition experts, prosecutors, traffic safety professionals, with a forum in which to share information, countermeasures, and best practices for reducing. (theiacp.org)
  • This program is intended for officers who are Certified Drug Recognition Experts (DREs) and prosecutors who handle DUI and drug cases as well as DUI instructors and SFST practitioners. (campusce.net)
  • Even at the time of birth, assessment of fetal exposure to drugs is limited to a single cord plasma concentration measurement and reported as the umbilical vein (UV)/maternal plasma (MP) drug concentration ratio. (aspetjournals.org)
  • In fluid dynamics, the drag coefficient (commonly denoted as: c d {\displaystyle c_{d}} , c x {\displaystyle c_{x}} or c w {\displaystyle c_{w}} ) is a dimensionless quantity that is used to quantify the drag or resistance of an object in a fluid environment, such as air or water. (wikipedia.org)
  • Dried blood spots (DBS) can be used in developing countries to alleviate the logistic constraints of using blood plasma specimens for viral load (VL) and HIV drug resistance (HIVDR) testing, but they should be assessed under field conditions. (asm.org)
  • This includes family history, physical exam and further cardiac evaluation (EKG and echocardiogram). (drugs.com)
  • Regular blood testing, along with cardiac and other body system evaluation is required during treatment. (petmd.com)
  • Part of Europe's leading Injectable conference series , we will assess innovations in drug product formulation and biologics, innovations in device design, quality management and connectivity for enhanced subcutaneous delivery. (smi-online.co.uk)
  • Furthermore, this year's event will assess the evolving regulatory environment of injectable drug delivery with industry and regulatory representatives presenting updates on current guidelines. (smi-online.co.uk)
  • There is mounting evidence to suggest that lean body mass (LBM) may be a better predictor of drug dosage than either total bodyweight (TBW) or body surface area (BSA), although the rationale for this is not clear. (springer.com)
  • BSA is an accurate predictor of drug dosage in infants and children, but whether LBM is superior to BSA in this population remains to be determined. (springer.com)
  • In most studies in adults in which dosage based on LBM has been evaluated prospectively, LBM has been shown to be superior to other measures of body size as a predictor of drug dosage. (springer.com)
  • Do not ever increase or reduce the dosage of drugs without prior consulting with your veterinarian. (petmd.com)
  • This text is directed at the student or professional who feels uncomfortable with mathematics and wants to improve their ability to perform accurate drug dosage calculations. (nelson.com)
  • Volume of distribution of relatively hydrophilic drugs correlates very well with LBM, with correlation coefficients of up to 0.9. (springer.com)
  • Since this tends to be large compared to the frontal area, the resulting drag coefficients tend to be low, much lower than for a car with the same drag, frontal area, and speed. (wikipedia.org)
  • Two objects having the same reference area moving at the same speed through a fluid will experience a drag force proportional to their respective drag coefficients. (wikipedia.org)
  • Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice. (rxlist.com)
  • Through observing my parents and learning in nursing school how the body works, this had shaped my worldview on the practice of medicine. (ipl.org)
  • More than 1200 problems reflecting current drugs and protocols are included for learners to practice their skills and reinforce their learning. (nelson.com)
  • Recreational drugs are chemical substances that affect the central nervous system, such as opioids or hallucinogens. (phys.org)
  • Many natural substances such as beers, wines, and some mushrooms, blur the line between food and drugs, as when ingested they affect the functioning of both mind and body. (phys.org)
  • What Drugs, Substances, or Supplements Interact with Lexapro? (rxlist.com)
  • The Government of Canada has proposed An Act respecting cannabis and to amend the Controlled Drugs and Substances Act, the Criminal Code and other Acts, which has passed first reading in the Senate. (mondaq.com)
  • In November 2016, Health Canada issued a Guidance Document: Information and Submission Requirements for Biosimilar Biologic Drugs (as previously reported). (mondaq.com)
  • But despite the rosy statistics and the prospect for further progress in 2016, the pharmaceuticals industry faces challenges, with increased political focus on drug pricing having punctured both biotech and specialty pharma valuations in recent months. (euractiv.com)
  • The prospect of Hillary Clinton becoming president of the United States could further undermine confidence in the sector's profitability in 2016, given her pledge to rein in drug costs. (euractiv.com)
  • That will continue in 2016, analysts believe, with further advances in cancer treatments that work by boosting the immune system, and significant progress in drugs for autoimmune diseases. (euractiv.com)
  • Switzerland's Roche, the world's largest cancer drug company, could be a notable winner on both counts, with a new cancer drug on track for fast approval in 2016. (euractiv.com)
  • With the incident rate of MDR-TB on the rise, there is a need to investigate optimal treatment regimens using effective drugs. (clinicaltrials.gov)
  • Issues of interest include phenomena such as subliminal perception , blindsight , denial of impairment , and altered states of consciousness produced by alcohol and other drugs, or spiritual or meditative techniques. (wikipedia.org)
  • This strain of drug-resistant bacteria can also be spread to other people through the air. (clinicaltrials.gov)
  • It may also help your body get rid of bacteria/viruses that might be causing the diarrhea. (medhelp.org)
  • A simple equation based on TBW and height, or determination by bioelectrical impedance are probably the most suitable for use in drug disposition studies. (springer.com)
  • Body composition and its variations under tocilizumab therapy will also be analyzed. (clinicaltrials.gov)
  • Evaluation of photodynamic therapy to prevent lens epithelial proliferation will require specific localization of the drug to lens epithelium. (springer.com)
  • 37,38 Several studies show that whole-body vibration therapy improves muscle and bone circulation, increasing the supply of nutrients needed to build bones. (ahrq.gov)
  • We aim to provide a description of the state of the science and an overview of the key issues related to the use of whole-body vibration therapy to improve bone density and treat osteoporosis, including modalities, standards, relevant patient populations, outcomes measured, and implications for future research. (ahrq.gov)
  • Study objective: To describe characteristics of postmenopausal women on long-term bisphosphonate therapy who fall into one of four fracture risk categories (low, mild, moderate, high), and to determine the prevalence of women eligible for a drug holiday. (ku.edu)
  • Then, in a New Jersey suburb in 1962, a 19-year-old recreational drug enthusiast named Howard Lotsof laid hands on 500 mg of powdered iboga root. (wired.com)
  • Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. (curehunter.com)
  • Chemotherapy refers to the use of cytotoxic drugs in cancer treatment. (medindia.net)
  • Consult your doctor promptly for proper evaluation and treatment if you have these symptoms. (medhelp.org)
  • Your loved one might deny taking drugs altogether or refuse to seek treatment. (healthline.com)
  • Chemotherapeutic drugs are highly toxic to different body systems and various complications are seen during and after treatment. (petmd.com)
  • Which body organ suffers the most from the consumption of alcohol? (prezi.com)
  • A drug , broadly speaking, is any substance that, when absorbed into the body of a living organism, alters normal bodily function. (phys.org)
  • Nevertheless, a small opening remains, which, while keeping a drug or other substance within, can be used as a exhaust port. (medgadget.com)
  • With drug dependence, you need more and more of the substance to achieve the same effect (tolerance). (healthline.com)
  • It is also administered into a body space or cavity through a catheter. (bioportfolio.com)
  • We've written about a bunch of different drug ferrying nanoparticles that scientists around the world have been developing. (medgadget.com)
  • Actovegin ® is a biological drug manufactured from a natural source: it is a calf blood hemodialysate. (springer.com)
  • Parkinson disease is a progressive neurodegenerative disorder that is pathologically defined by degeneration of the dopaminergic neurons in the substantia nigra and development of Lewy bodies in the residual dopaminergic neurons. (aafp.org)
  • My advice is do not be lulled into a false sense of security, as drug companies are past masters of disguise and extorting vast billions from governments on drugs that predominantly do not work according to authority research. (euractiv.com)
  • A scale adapted from evaluations of a number of community projects that sought to establish the extent to which people were aware of and participated in community programmes. (europa.eu)
  • Designed to gauge the perception of the size and extent of the drug problem. (europa.eu)
  • Your veterinarian will take bone marrow samples to be sent to a veterinary pathologist for further evaluation and to determine the extent of disease. (petmd.com)
  • As shown here, in most clinical scenarios, this UV/MP ratio does not reflect the extent of fetal drug exposure relative to that in the mother. (aspetjournals.org)
  • Their system, adapted from technology they previously developed and commercialized through U.K.-based CN BioInnovations, also incorporates several on-board pumps that can control the flow of liquid between the "organs," replicating the circulation of blood, immune cells, and proteins through the human body. (eurekalert.org)
  • These on-board pumps control the flow of liquid between the "organs," replicating the circulation of blood, immune cells and proteins through the human body. (upi.com)
  • 3. Does a driver consent to a test of their breath, urine or blood for alcohol or drug concentration when they accept the privilege to drive? (prezi.com)
  • They offer creation of exercise plans, evaluation of eating habits, and testing, ranging from saliva to dried blood tests. (ipl.org)
  • DALLAS, May 22, 2017 -- Long-term anabolic-androgenic steroid use may reduce the heart's ability to pump blood throughout the body, according to new research in the American Heart Association's journal Circulation . (eurekalert.org)
  • Diastolic function, which is when the left ventricle relaxes and fills with blood, was impaired both for on-drug and off-drug anabolic steroid users. (eurekalert.org)
  • The DAST is designed to identify individuals who are abusing psychoactive drugs and to yield a quantitative index score of the degree of problems related to drug use and misuse. (europa.eu)
  • This report aims to provide information on new drug developments to support a 'new drugs update' to the 2008 guideline. (nih.gov)
  • LBM can be used to accurately predict the loading dose required for these drugs to attain a target peak plasma concentration. (springer.com)
  • Third, by mutating critical amino acids, the authors reduced the threat of the interference of neutralizing antibodies that are generated against the drug. (thejns.org)
  • Therefore, hepatotoxicity is an important endpoint in the safety evaluation of drugs and chemicals. (wiley.com)
  • The websites of the American Diabetes Association, the European Association for the Study of Diabetes, the US Food and Drug Administration, the European Medicines Evaluation Agency and the Medicines and Healthcare Products Regulatory Agency were searched, as were manufacturers' websites. (nih.gov)
  • You can also visit the Food and Drug Administration (FDA) website ( http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm ) or the manufacturer's website to obtain the Medication Guide. (medlineplus.gov)
  • United States Food and Drug Administration. (medscape.com)
  • The Food and Drug Administration-approved eculi- with generalized body pain, headache, and emesis. (cdc.gov)
  • Across the Atlantic, the Food and Drug Administration (FDA) approved 45 novel drugs, four more than in 2014 and the most since the all-time record of 53 set in 1996. (euractiv.com)
  • This apparatus was used to evaluate in a double-blind, parallel fashion the effect of three different antihypertensive drugs and of a placebo on radial artery compliance. (ahajournals.org)
  • Abnormal, or Cheap Diazepam tests including when buying drugs when. (virgilio.it)
  • Heavily in 1999 final approvals front of Cheap Diazepam body, either required. (virgilio.it)
  • Most people relate anabolic steroids to cheating among athletes and fail to realize that there is a large population of men who have developed dependence upon these drugs, but who are not readily visible. (eurekalert.org)
  • Dependence refers to a physical state in which your body is dependent on the drug. (healthline.com)
  • Addiction can occur with or without physical dependence on the drug. (healthline.com)
  • Therefore, we developed a novel maternal-fetal physiologically based pharmacokinetic (m-f-PBPK) model to predict fetal exposure to drugs and populated this model with gestational age-dependent changes in maternal-fetal physiology. (aspetjournals.org)
  • It is concluded that, of the eight, diammine (1,1-cyclobutane dicarboxylato)platinum(II) (carboplatin, CBDCA, JM8) had the features most desirable to merit its clinical evaluation. (nih.gov)