Cell Death: The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.Cause of Death: Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.Death: Irreversible cessation of all bodily functions, manifested by absence of spontaneous breathing and total loss of cardiovascular and cerebral functions.Death, Sudden, Cardiac: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)Brain Death: A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.Attitude to Death: Conceptual response of the person to the various aspects of death, which are based on individual psychosocial and cultural experience.Caspases: A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Receptors, Death Domain: A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a death domain due to the fact that many of these receptors are involved in signaling APOPTOSIS. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Mortality: All deaths reported in a given population.Autopsy: Postmortem examination of the body.Caspase 3: A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Necrosis: The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Proto-Oncogene Proteins c-bcl-2: Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Antigens, CD95: A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.Mitochondria: Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)Infant, Newborn: An infant during the first month after birth.DNA Fragmentation: Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Cell Line, Tumor: A cell line derived from cultured tumor cells.Caspase Inhibitors: Endogenous and exogenous compounds and that either inhibit CASPASES or prevent their activation.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Autophagy: The segregation and degradation of damaged or unwanted cytoplasmic constituents by autophagic vacuoles (cytolysosomes) composed of LYSOSOMES containing cellular components in the process of digestion; it plays an important role in BIOLOGICAL METAMORPHOSIS of amphibians, in the removal of bone by osteoclasts, and in the degradation of normal cell components in nutritional deficiency states.In Situ Nick-End Labeling: An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.Caspase 8: A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.Infant Mortality: Postnatal deaths from BIRTH to 365 days after birth in a given population. Postneonatal mortality represents deaths between 28 days and 365 days after birth (as defined by National Center for Health Statistics). Neonatal mortality represents deaths from birth to 27 days after birth.Death Domain Receptor Signaling Adaptor Proteins: Intracellular signaling adaptor proteins that bind to the cytoplasmic death domain region found on DEATH DOMAIN RECEPTORS. Many of the proteins in this class take part in intracellular signaling from TUMOR NECROSIS FACTOR RECEPTORS.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.BH3 Interacting Domain Death Agonist Protein: A member of the Bcl-2 protein family that reversibly binds MEMBRANES. It is a pro-apoptotic protein that is activated by caspase cleavage.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.United Statesbcl-2-Associated X Protein: A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA. Several isoforms of BCL2-associated X protein occur due to ALTERNATIVE SPLICING of the mRNA for this protein.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Reactive Oxygen Species: Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Caspase 9: A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 9 is activated during cell stress by mitochondria-derived proapoptotic factors and by CARD SIGNALING ADAPTOR PROTEINS such as APOPTOTIC PROTEASE-ACTIVATING FACTOR 1. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.Fas Ligand Protein: A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS.Enzyme Activation: Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Amino Acid Chloromethyl Ketones: Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process.Homicide: The killing of one person by another.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Registries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Mice, Inbred C57BLSuicide: The act of killing oneself.Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Maternal Mortality: Maternal deaths resulting from complications of pregnancy and childbirth in a given population.Cysteine Proteinase Inhibitors: Exogenous and endogenous compounds which inhibit CYSTEINE ENDOPEPTIDASES.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Poly(ADP-ribose) Polymerases: Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.bcl-X Protein: A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING of the BCL2L1 mRNA and are referred to as Bcl-XS and Bcl-XL.bcl-Associated Death Protein: A pro-apoptotic protein and member of the Bcl-2 protein family that is regulated by PHOSPHORYLATION. Unphosphorylated Bad protein inhibits the activity of BCL-XL PROTEIN.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Risk: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Wounds and Injuries: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Programmed Cell Death 1 Receptor: An inhibitory T-lymphocyte receptor that has specificity for CD274 ANTIGEN and PROGRAMMED CELL DEATH 1 LIGAND 2 PROTEIN. Signaling by the receptor limits T cell proliferation and INTERFERON GAMMA synthesis. The receptor also may play an essential role in the regulatory pathway that induces PERIPHERAL TOLERANCE.Life Expectancy: Based on known statistical data, the number of years which any person of a given age may reasonably expected to live.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Receptors, TNF-Related Apoptosis-Inducing Ligand: Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved death domains that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.TNF-Related Apoptosis-Inducing Ligand: A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Tumor Suppressor Protein p53: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.Enzyme Inhibitors: Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Vital Statistics: Used for general articles concerning statistics of births, deaths, marriages, etc.Membrane Potential, Mitochondrial: The voltage difference, normally maintained at approximately -180mV, across the INNER MITOCHONDRIAL MEMBRANE, by a net movement of positive charge across the membrane. It is a major component of the PROTON MOTIVE FORCE in MITOCHONDRIA used to drive the synthesis of ATP.Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.Sex Factors: Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.Hospitalization: The confinement of a patient in a hospital.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Receptors, Tumor Necrosis Factor: Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.Asphyxia: A pathological condition caused by lack of oxygen, manifested in impending or actual cessation of life.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Jurkat Cells: A CELL LINE derived from human T-CELL LEUKEMIA and used to determine the mechanism of differential susceptibility to anti-cancer drugs and radiation.RNA, Small Interfering: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.EnglandPopulation Surveillance: Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.Hydrogen Peroxide: A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.Terminal Care: Medical and nursing care of patients in the terminal stage of an illness.Bereavement: Refers to the whole process of grieving and mourning and is associated with a deep sense of loss and sadness.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Neuroprotective Agents: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Receptor-Interacting Protein Serine-Threonine Kinases: A family of serine-threonine kinases that plays a role in intracellular signal transduction by interacting with a variety of signaling adaptor proteins such as CRADD SIGNALING ADAPTOR PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; and TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN. Although they were initially described as death domain-binding adaptor proteins, members of this family may contain other protein-binding domains such as those involving caspase activation and recruitment.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Mortality, Premature: Deaths that occur before LIFE EXPECTANCY is reached within a given population.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Accidents, Traffic: Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.Cytoprotection: The process by which chemical compounds provide protection to cells against harmful agents.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.bcl-2 Homologous Antagonist-Killer Protein: A multi-domain mitochondrial membrane protein and member of the bcl-2 Protein family. Bak protein interacts with TUMOR SUPPRESSOR PROTEIN P53 and promotes APOPTOSIS.Annexin A5: A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.WalesCoronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.Up-Regulation: A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Wounds, Gunshot: Disruption of structural continuity of the body as a result of the discharge of firearms.TNF Receptor-Associated Death Domain Protein: A 34 kDa signal transducing adaptor protein that associates with TUMOR NECROSIS FACTOR RECEPTOR TYPE 1. It facilitates the recruitment of signaling proteins such as TNF RECEPTOR-ASSOCIATED FACTOR 2 and FAS ASSOCIATED DEATH DOMAIN PROTEIN to the receptor complex.Poisoning: A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.JNK Mitogen-Activated Protein Kinases: A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.Recurrence: The return of a sign, symptom, or disease after a remission.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Inhibitor of Apoptosis Proteins: A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat.Caspase 1: A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Down-Regulation: A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.Caspase 2: A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Forensic Pathology: The application of pathology to questions of law.Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Stillbirth: The event that a FETUS is born dead or stillborn.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Lung Neoplasms: Tumors or cancer of the LUNG.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Animals, Newborn: Refers to animals in the period of time just after birth.Caspase 7: A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 3 and CASPASE 10. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Tissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Propidium: Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits.Cysteine Endopeptidases: ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.RNA Interference: A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.NF-kappa B: Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).Great BritainCell Count: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.Epidemiologic Methods: Research techniques that focus on study designs and data gathering methods in human and animal populations.Odds Ratio: The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Apoptotic Protease-Activating Factor 1: A CARD signaling adaptor protein that plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY). It binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX and activates INITIATOR CASPASES such as CASPASE 9.Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Breast Neoplasms: Tumors or cancer of the human BREAST.Staurosporine: An indolocarbazole that is a potent PROTEIN KINASE C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)Cytochrome c Group: A group of cytochromes with covalent thioether linkages between either or both of the vinyl side chains of protoheme and the protein. (Enzyme Nomenclature, 1992, p539)Smoking: Inhaling and exhaling the smoke of burning TOBACCO.Genes, bcl-2: The B-cell leukemia/lymphoma-2 genes, responsible for blocking apoptosis in normal cells, and associated with follicular lymphoma when overexpressed. Overexpression results from the t(14;18) translocation. The human c-bcl-2 gene is located at 18q24 on the long arm of chromosome 18.Neurotoxins: Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.Microscopy, Fluorescence: Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.Acute Disease: Disease having a short and relatively severe course.Protein-Serine-Threonine Kinases: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.Life Tables: Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.JapanCalcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Comorbidity: The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.Calpain: Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesDNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Receptors, Tumor Necrosis Factor, Type I: A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.Cerebrovascular Disorders: A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Child Mortality: Number of deaths of children between one year of age to 12 years of age in a given population.SwedenChi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Microtubule-Associated Proteins: High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.Grief: Normal, appropriate sorrowful response to an immediate cause. It is self-limiting and gradually subsides within a reasonable time.Perinatal Mortality: Deaths occurring from the 28th week of GESTATION to the 28th day after birth in a given population.Proto-Oncogene Proteins c-akt: A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
  • Though the post-mortem mentioned pneumonia as the cause of death, the autopsy report revealed 22 injury marks on Rajkumar's body, most below the thighs, indicating that he was subjected to third degree torture while in custody. (newkerala.com)
  • Bartylla's body was transported to the Ramsey County Medical Examiner's Office for an autopsy to determine the cause. (brainerddispatch.com)
  • Otherwise, a medical examiner (forensic pathologist) will intervene with an autopsy to determine the cause of death in the event that a case requires police investigation. (deathreference.com)
  • The form also includes a place to record whether an autopsy was performed and the manner of death such as natural, accident, suicide, homicide, could not be determined, or pending investigation. (deathreference.com)
  • An undertaker revealed on Monday that Jett Travolta's body shows no sign of head trauma and his death certificate indicated that he was killed by a seizure after doctors performed an autopsy on the 16-year-old son of the U.S actor. (sponkit.com)
  • Authorities didn't release the results of an autopsy performed Monday, but Campbell saw the body and the death certificate, which was based on its findings. (sponkit.com)
  • Just when we thought the ridiculously inadequate, travesty of an investigation into the horrific death of Kendrick Johnson, the Georgia high school football player found stuffed in a gym mat, couldn't get any worse, it does: a second autopsy revealed his body and skull had been stuffed with newspaper before burial. (mybrownbaby.com)
  • Lowndes County Sheriff Chris Prine insists KJ's death was nothing more than a freak accident and said in media reports that an autopsy revealed KJ died from accidental "positional asphyxiation," caused when he fell into and got stuck upside down in a 700-lb, 7"-tall gym mat he may have reached into to retrieve his shoe. (mybrownbaby.com)
  • Indeed, within 24 hours after the teen's body was found, Prine pronounced there was "no foul play," sans an autopsy and coroner input, and then took their time-four months-to release autopsy results. (mybrownbaby.com)
  • Though the U.S. Justice Department declined to open a civil rights investigation into KJ's death, the Johnsons did win a court order to have their son's body exhumed for a second autopsy. (mybrownbaby.com)
  • And now, news that every organ, from the pelvis to the skull, was gone from his body, with no one-not state investigators who performed the first autopsy, or the funeral home that prepared KJ's body for burial-copping to destroying his body and any evidence that may have helped to figure out how, exactly, that child died. (mybrownbaby.com)
  • The death of a Las Vegas woman who died after receiving a buttocks enhancement injection in a makeshift medical office was accidental, according to an autopsy. (foxnews.com)
  • An autopsy report released by the Manila Police District (MPD) stated "shock secondary to ingestion of toxic substance" as the cause of death of Suzaine Dagohoy, one of the two victims who took a sip of the "Hokkaido''-flavored drink at the ErgoCha Milk Tea House on Bustillos Street in Sampaloc. (inquirer.net)
  • PARADISE, Calif. (Reuters) - The charred remains of 14 more people have been found in and around a Northern California town overrun by flames from a massive wildfire, officials said on Saturday, raising the death toll to at least 23. (reuters.com)
  • Several of the bodies discovered earlier this week were found in or near burned out cars, police have said. (reuters.com)
  • Researchers also found no association between changes in body fat percentage or body weight and death risk. (eurekalert.org)
  • An official identified the Naxal whose body was found on Saturday as Mahadev, 'section commander' of the outlawed group's 'platoon number 31' who carried a reward of Rs 3 lakh on his head. (yahoo.com)
  • The body of a woman found in a North Toledo warehouse Thursday has been identified as Cindy Sumner, the 21-year-old with muscular dystrophy, multiple sclerosis, and learning disabilities who disappeared Aug. 6. (toledoblade.com)
  • She said the forensic examination was made difficult by the fact that the body had lain in water for some time before it was found by Toledo police detectives acting on a tip. (toledoblade.com)
  • Family members of Miss Sumner said Friday her necklace was found by police on or nearby the badly decomposed body. (toledoblade.com)
  • His body was found shortly before the decomposed body of Miss Sumner was located at a different site. (toledoblade.com)
  • The man's body was found in the river near Chipping Hill. (itv.com)
  • OKLAHOMA CITY - Oklahoma City Police say a body has been found in downtown Oklahoma City Friday night. (kfor.com)
  • The body was found between two parking garages in the area of Robert S. Kerr and Hudson. (kfor.com)
  • The body of Jenna Bartylla was found Friday, Jan. 10, after Crow Wing County Sheriff's Office personnel used a drone to search a wooded area in Barrows. (brainerddispatch.com)
  • Her body was never found. (mantecabulletin.com)
  • Police all but demolished the restaurant that Viens and his wife operated looking for evidence of a cooked body but found nothing. (mantecabulletin.com)
  • The cause of death for a man found in his ransacked Venice apartment was yet to be determined. (laweekly.com)
  • Perini's body was found Jan. 22 shortly before 8 p.m. by his brother after the latter went to check on the victim because he hadn't heard from him for "several days," police told us. (laweekly.com)
  • Bacteria found on the body could help forensic scientists more accurately determine the time of death or other aspects of a crime scene, a new study has found. (hindustantimes.com)
  • The Orange County coroner's office has finished the autopsies on two of the three bodies found inside a burning SUV in Orange on Monday. (ocregister.com)
  • When firefighters arrived, they found an SUV on fire and three bodies inside. (ocregister.com)
  • The results bore this out: in the years following SCREEN, very likely because tumors were thinner when found (as a general rule, the thinner the lesion, the easier to treat), the melanoma death rate was cut in half. (skincancer.org)
  • Authorities have found a body matching the description of a 33-year-old Texas mother who disappeared Monday near Galveston after rescuing her son from the waves. (dallasnews.com)
  • On Tuesday, a passerby found a body on the shore about three miles from where Mosley disappeared. (dallasnews.com)
  • THE body of a "human hamster" who created a nest out of rubbish in his front room may have lain there for as long as eight months before he was found. (express.co.uk)
  • PC Lindsay Miell found his body under a pile of papers at the foot of his stairs which reached from floor to ceiling. (express.co.uk)
  • FORT HOOD, Texas (AP) - The Army says the bodies have been found of four Fort Hood soldiers who were swept away in a rain-swollen creek during a training exercise at the sprawling Army base in Central Texas. (q13fox.com)
  • Gen. John Uberti says the bodies were found Friday, a day after their 2½-ton truck overturned in Owl Creek at Fort Hood. (q13fox.com)
  • A decomposed male body was found in the wooded area near the end of Leggett Street in Lumberton the evening of Aug. 8, and the death is being investigated as a homicide. (wmbfnews.com)
  • We now know what killed a Fort Wayne man whose body was found floating in the Pigeon River. (abc57.com)
  • And if a body is found encased in concrete it may appear fresher than it is, so crime investigators need to look at a time of death years, rather than months, in the past. (smithjournal.com.au)
  • The discovery added yet another horrific layer to KJ's death and further fueled skepticism of official findings that he accidentally fell into the mat and suffocated to death-findings that are incredibly hard to believe considering that when KJ's body was found, the strapping, three-sport athlete's face was so battered and deformed that his post-mortem picture recalls that of slain Civil Rights icon, Emmett Till. (mybrownbaby.com)
  • Investigators didn't bother to collect as potential evidence a pair of orange-and-black gym shoes found a few yards away from KJ's body. (mybrownbaby.com)
  • Lunetta P, Modell JH, Sajantila A (2004) What is the incidence and significance of "dry-lungs" in bodies found in water? (springer.com)
  • However, somewhat surprisingly, this study found that compared to those in the 'healthy' BMI category, those categorised as 'overweight' (a BMI of 25 " less than 30) were actually at reduced risk of death. (drbriffa.com)
  • However, the pair disappeared, and while Mallory's frozen remains were discovered in 1999 at 26,760 feet, the body of Irvine, who is believed to have been carrying a camera, has not been found. (washingtonpost.com)
  • The bodies of the two girls, ages 6 and 12, were found dumped on a Guatemala City street Wednesday. (cnn.com)
  • Investigators are running tests to determine if there is any connection between the two girls and two adult women whose bodies were found that same morning with gunshot wounds, Cabrera said. (cnn.com)
  • These were comparable to figures found in patients on the verge of death," Windsor said. (sciencealert.com)
  • A body has been found at the home of a teenager who has been missing since the middle of August. (itv.com)
  • Police searching for a missing teenager from Suffolk have found a body in his overgrown back garden. (itv.com)
  • Suffolk Police said an officer went to the house on Thursday as part of their inquiries and found the body during a search of the garden. (itv.com)
  • Lewy body dementia was discovered in the early 1900s, when researcher Frederic Lewy, who worked in the laboratory of neurologist Alois Alzheimer, found the abnormal buildup in the brain tissue of dementia patients. (livescience.com)
  • No one knows why Lewy bodies accumulate, but they are also found in the brains of people with Parkinson's disease, and in the brains of those with Alzheimer's. (livescience.com)
  • However, a 2010 study published in the journal The Lancet Neurology found that a drug called memantine, which is used to slow the loss of cognitive abilities in people with Alzheimer's, can also improve symptoms in people with Lewy body dementia and Parkinson's disease. (livescience.com)
  • Counties with the smallest increases in insurance coverage had the largest increases in deaths from cardiovascular disease, the study found. (miamiherald.com)
  • The body of a missing man has been found in a Western Australian forest. (news.com.au)
  • The body of a woman, believed to be missing grandmother Marilyn Grubb, has been found in the outback. (news.com.au)
  • Police say a body was found inside a burned vehicle Sunday morning in downtown Savannah. (savannahnow.com)
  • A case of accidental death was registered at Marine Drive police station on Monday. (indianexpress.com)
  • Delivering a verdict of accidental death, Central Hampshire coroner Grahame Short said: "Because of the period of time which has elapsed, it's not possible to ascertain whether he had been drinking, for example, and then fallen, or if he had a fall because he tripped. (express.co.uk)
  • They also think investigators rushed to rule KJ's death accidental. (mybrownbaby.com)
  • He's made photos of people sawing into heads, photos of people pulling brains out of bodies, photos of people smiling while they work with human body parts, and one particularly horrifying photo of a 13-year-old girl with her chest cut open. (wired.com)
  • In the Death Zone, climbers' brains and lungs are starved for oxygen, their risk of heart attack and stroke is increased, and their judgment quickly becomes impaired. (sciencealert.com)
  • Michael's body was driven to Little Rock and placed in a 38-degree cooler at Ruebel Funeral Home. (latimes.com)
  • The for-profit company, started in 2000 by James Rogers, a funeral insurance salesman, promotes body donation as an altruistic alternative to funerals. (latimes.com)
  • Last year, at least 676 bodies went to ScienceCare, according to figures collected by the Arizona Board of Funeral Directors and Embalmers. (latimes.com)
  • And discussions of death and funeral plans have been taboo . (businessinsider.com)
  • Baby boomers are insisting upon more control over their funeral and disposition so that their choices after death match their values in life. (businessinsider.com)
  • She wrote that human remains are temporarily preserved by replacing blood with a formaldehyde-based embalming fluid shortly after death, placed in a decorative wood or metal casket, displayed to family and friends at the funeral home and buried within a concrete or steel vault in a grave, perpetually dedicated and marked with a tombstone. (businessinsider.com)
  • Funeral directors often struggle to obtain a physician's signature on a death certificate. (deathreference.com)
  • The body of John Travolta's son was being cremated and his parents planned to return to the United States with the ashes on Tuesday, according to Keith McSweeney, who is the director of the funeral home handling the body. (sponkit.com)
  • Glen Campbell, who is the assistant director of the funeral home, revealed that the body is in "great condition," despite police officials who had said the teen hit his head on a bathtub. (sponkit.com)
  • Maclean said no details were immediately available about the circumstances of the deaths and that the victims' badly burned condition would make identification difficult. (reuters.com)
  • Deputies allege in court documents that Algarad killed one of the victims sometime after June 1, 2009, and Burch helped bury the body in July 2009. (wxii12.com)
  • Elizabeth Wettlaufer: The bodies of two alleged victims of nurse accused of serial murder were removed from graves Tuesday in London and Innerkip. (chathamdailynews.ca)
  • The bodies of two Southwestern Ontarians believed to be victims of alleged nursing home homicides were exhumed Tuesday in London and Innerkip. (chathamdailynews.ca)
  • There's no word yet if the bodies of other alleged victims are to be exhumed, Bough said. (chathamdailynews.ca)
  • Sarin, a chemical weapon that U.S. officials say has been used by Syrian President Bashar al-Assad's regime in the country's ongoing civil war, blocks the "off switch" for muscles and glands, paralyzing and suffocating its victims by exhausting their bodies, experts say. (go.com)
  • Left exposed to the elements, dead bodies break down very quickly. (howstuffworks.com)
  • While the body as a whole may be dead, little things within the body are still alive. (howstuffworks.com)
  • Disposal of a dead bod-y is largely regulated by cultural and religious beliefs. (howstuffworks.com)
  • Ambulances raced racing towards the site of the blast as medics and residents frantically tried to gather up the dead bodies. (palestinechronicle.com)
  • The burning of dead bodies has a long history in Eastern cultures, and despite some churches' disapproval, has become mainstream for most of the world population. (pantheism.net)
  • This study takes us a step further (than the human microbiome), and tells us about the necrobiome, the collection of microbes on a dead body," said Dr Robert DeSalle, Curator of Molecular Systematics at the American Museum of Natural History, who was not affiliated with the CUNY study. (hindustantimes.com)
  • A death certificate is the official document that declares a person is dead. (deathreference.com)
  • Even after someone is declared dead , life continues in the body, suggests a surprising new study with important implications. (seeker.com)
  • Mortician, coroner covering dead body in morgue. (gettyimages.com)
  • An NDE might involve walking toward a bright light at the end of a tunnel, meeting gods, speaking with relatives who are long-dead, out-of-body experiences (OBEs) or feeling bathed in light. (medicalnewstoday.com)
  • By using an ecological lens to examine dead bodies, scientists are bridging the gap between forensic science and the ecological concept of succession. (sciencenews.org)
  • Over My Dead Body" is the 6th episode of the supernatural drama television series Grimm of season 2 and the 28th overall, which premiered on October 5, 2012, on NBC. (wikipedia.org)
  • Opening quote: "Whilst he thus gazed before him, he saw a snake creep out of a corner of the vault and approach the dead body. (wikipedia.org)
  • Over My Dead Body" received positive reviews. (wikipedia.org)
  • Nick McHatton from TV Fanatic, gave a 4.5 star rating out of 5, stating: "'Over My Dead Body' went back to telling a strictly serial story - and Grimm benefited from it immensely. (wikipedia.org)
  • The Roman Catholic Church permits ordinary cremation of bodies as long as it is not done in denial of the beliefs in the sacredness of the human body or the resurrection of the dead. (wikipedia.org)
  • Turkish officials suspect the body of Khashoggi, a Washington Post columnist and critic of powerful Crown Prince Mohammed bin Salman, was cut up but the Saudi official said it was rolled up in a rug and given to a "local cooperator" for disposal. (reuters.com)
  • Crow Wing County Sheriff's Capt. Joe Meyer said the sheriff's office Friday morning secured the area and organized its drone team to search for the body, which was located about 10 a.m. (brainerddispatch.com)
  • Dumb jokes aside, an internet search for "hyperthermia case study" reveals cases of death occuring at 109° and lower. (straightdope.com)
  • Yet scientists continue to search, and some are intrigued by a small study of cardiac arrest survivors that shows there may be a physical link between carbon dioxide in the blood and the likelihood that someone will wake up remembering floating above their body and moving towards a peaceful light. (go.com)
  • While donation of organs for transplant is highly regulated by state and federal law, the willing of bodies for scientific research and training is not. (latimes.com)
  • As these organisms work their way to other organs, the body becomes discolored, first turning green, then purple, then black. (howstuffworks.com)
  • Internal organs and tissues have liquefied, which will swell the body until it bursts open. (howstuffworks.com)
  • Prior to the 1950s, "clinical death" meant vital organs, such as the lungs, heart and brain, had stopped working. (naturalnews.com)
  • If such a connection is established, the findings could help to explain why the donated organs of people who were young and healthy before death - for example, if they died in a sudden accident - could still lead to increased risk of cancer in the organ recipient. (seeker.com)
  • Scientists hope the results of the study will spur further research into this life or death matter . (naturalnews.com)
  • Professor Chris French, editor of The Skeptic magazine in the United Kingdom, said three factions have been prying into near-death experiences for years, including scientists looking for physiological explanations. (go.com)
  • A new study suggests that analysing the human microbiome, the bacteria and other microbes that live on and in our bodies, for clues about postmortem interval of a cadaver. (hindustantimes.com)
  • However, in a new study researchers at City University of New York (CUNY) have turned to analysing the human microbiome, the bacteria and other microbes that live on and in our bodies, for clues about the postmortem interval of a cadaver. (hindustantimes.com)
  • Death certificates serve two purposes: they prevent murder cover-ups by restricting those who can complete them for non-natural deaths to trained officials who generally have great latitude on whom they perform postmortem examinations, and they provide public health statistics. (deathreference.com)
  • Gene expression - when information stored in DNA is converted into instructions for making proteins or other molecules - actually increases in some cases after death, according to the new paper , which tracked postmortem activity and is published in the journal Open Biology. (seeker.com)
  • We have framed our discussion of death in reference to 'postmortem time' because on the one hand, there is no reason to suspect that minutes after an animal dies, gene transcription will abruptly stop. (seeker.com)
  • Since gene transcription associated with cancer and inflammation also can increase postmortem, analyzing those activities and patterns could shed light on how these health problems arise in the living and how the body reacts once they have been established. (seeker.com)
  • Inside one classroom, two young men wearing Palestinian boy scout scarves were engaged in the grisly task of collecting body parts. (palestinechronicle.com)
  • The grisly deaths of the girls come as Guatemala experiences a surge in the number of murdered women. (cnn.com)
  • Forbes became interested in forensics during the final year of her science degree, researching a specific area of a cemetery where bodies refused to decompose. (smithjournal.com.au)
  • There is a mass grave containing six bodies, which will be opened in two-and-a-half years to uncover how remains decompose next to each other. (smithjournal.com.au)
  • On the other hand," he added, "we know that within hours to days, the animal's body will eventually decompose by natural processes and gene transcription will end. (seeker.com)
  • President Trump has embraced the Saudi Arabian "Prince of Death" Mohammad bin Salman who has graduated from chopping hands and heads in public plazas to dismembering bodies in overseas consulates - the case of Jamal Khashoggi. (davidicke.com)
  • RIYADH (Reuters) - As Saudi Arabia faced intensifying international scepticism over its story about the death of journalist Jamal Khashoggi, a senior government official laid out a new version of the death inside the Saudi consulate in Istanbul that in key respects contradicts previous explanations. (reuters.com)
  • To explore the relationship between body composition and mortality in women diagnosed with colon cancer, Prizment and her colleagues turned to the Iowa Women's Health Study, a prospective study of 41,836 women ages 55 to 69 at baseline in 1986. (medpagetoday.com)
  • Prizment and her colleagues wrote in their paper that the possible mechanisms linking body composition to mortality in patients with colon cancer were unknown. (medpagetoday.com)
  • Recent research in the area of Terror Management Theory has suggested that we flee the body because it is a mortality reminder. (blogspot.com)
  • In my presentation I walked through three "exhibits," areas of inquiry that support the notion that the body does indeed function as a mortality reminder. (blogspot.com)
  • CDC senior research scientist Katherine Flegal, PhD, who led the study team, tells WebMD that the analysis presents a more nuanced picture of the relationship between body weight and mortality. (webmd.com)
  • Markeith Loyd, wanted in connection with the shooting death of an Orlando police officer, is shown in this undated booking photo in Orlando, Florida released January 9, 2017. (yahoo.com)
  • however, a growing body of research suggests that awareness may continue beyond clinical death , a medical term that no longer carries a black and white definition. (naturalnews.com)
  • The study, published in the journal Critical Care, surveyed 52 people in local hospitals who were revived from clinical death. (go.com)
  • Dealing with human body parts is a serious job, but just like any job, it becomes routine over time. (wired.com)
  • Death is hard to deal with, but with time it can become more approachable and a little easier to understand. (wired.com)
  • At the same time, without circulation to keep it moving through the body, blood starts to pool and settle. (howstuffworks.com)
  • Currently, when a deceased human is discovered, the forensic techniques for estimating time elapsed since death is not very precise. (hindustantimes.com)
  • With this very large data set, the researchers used a machine learning approach to scrutinise the bacterial communities and how they change over time as the bodies decomposed. (hindustantimes.com)
  • This could be important, because previous reports have suggested a time lag of 10 to 15 years before the full impact of the MetS on risk of death becomes evident. (ahajournals.org)
  • Human bodies tend to deteriorate in more or less the same way each time. (smithjournal.com.au)
  • Insects are crucial time-of-death indicators. (smithjournal.com.au)
  • The maximum number of divisions, liver cells and other would undergo, in the human body, in a life-time of 100 years is about 50 . (herenow4u.net)
  • It's as though parts of the body essentially go back in time, exhibiting cellular characteristics of very early human development. (seeker.com)
  • Death is a time-dependent process," Noble remarked. (seeker.com)
  • death because some cells remain alive for a short time and the transcriptional machinery is still operating in 'life mode. (seeker.com)
  • Asked by Reuters why the government's version of Khashoggi's death kept changing, the official said the government initial account was based on "false information reported internally at the time. (reuters.com)
  • Climbers have to give their bodies time to acclimate to the lung-crushing conditions in the Himalayas before attempting to summit Everest. (sciencealert.com)
  • At the time of dad's death I was over 18st," says the 37-year-old sales director. (telegraph.co.uk)
  • There is no cure for Lewy body dementia, and the disease is progressive, meaning it gets worse over time. (livescience.com)
  • In our example, you start with 170 pounds of lean tissue, and hope to have 164 pounds by the time you reach single-digit body fat, which is about 75 kilograms. (foxnews.com)
  • According to the medical examiner, the drugs in the actor's system at the time of his death were heroin, cocaine, benzodiazepines (anti-anxiety) and amphetamines (uppers like Adderall). (tmz.com)
  • If this is so, cases may best be built for ancient ethnic identity when multiple indicators of group-specific behaviors and practices (e.g., domestic and mortuary practices, culinary, dietary, dress, and residence patterns, body modification, and so forth) cohere in space and time, and biological distance measures covary with those material culture patterns ( 6 ). (pnas.org)
  • Dreaming about your own or a loved one's death is far more common around the new year period than any other time. (news.com.au)
  • pH drops to 11 by the end, but the final pH level depends on the total operation time and the amount of fat in the body. (wikipedia.org)
  • You could donate your body to science or ask for burial at sea. (howstuffworks.com)
  • Burial" at sea is much more straightforward - many jurisdictions only require that the body or ashes be weighted down, so that the remains do not go anywhere until decomposed, and deposited a certain number of kilometers away from shore. (pantheism.net)
  • However, they are produced by burning liters of oil, and if the body has mercury dental fillings or other concentrations of toxic chemicals, releasing a cloud of these into the atmosphere, which seems rather ironic for a green burial. (pantheism.net)
  • Survivors need death certificates to obtain burial permits, make life insurance claims, settle estates, and obtain death benefits. (deathreference.com)
  • They also include the method and site of body disposition (burial, cremation, donation, or other) and sign the form. (deathreference.com)
  • The death certificate then passes to the responsible local and state government offices, where, based on that document, a burial permit is issued. (deathreference.com)
  • After the death certificate has been signed, local authorities usually issue a certificate of disposition of remains, also known as a burial or cremation permit. (deathreference.com)
  • Re: How long is cyanide detectable in body tissues after death? (madsci.org)
  • Without an 'off switch,' the glands and muscles are constantly being stimulated," the U.S. Centers for Disease Control and Prevention says on its website , describing how sarin leads to sustained activation of acetylcholine receptors on vital tissues throughout the body. (go.com)
  • Among obese people, changes in BMI might have a significant effect on death risks. (eurekalert.org)
  • The bodies of 20 Palestinians were recovered from the rubble of destroyed buildings in the northern Gaza Strip on Wednesday evening, as Gazans took stock of a 23-day Israeli assault that has killed 1,360 people so far with no end in sight. (palestinechronicle.com)
  • On July 20, more than 100 people were killed in the district on the single bloodiest day in Gaza in more than five years, as Israel staged a blistering offensive, pounding the district to dust and leaving bodies scattered in the streets. (palestinechronicle.com)
  • People leaving the Thunder game spotted the body and immediately called police. (kfor.com)
  • The results were so impressive that in 2008, Germany began a national skin cancer screening program, offering people aged 35 or older a total-body skin exam every two years. (skincancer.org)
  • People use death certificates in multiple ways. (deathreference.com)
  • For fraudulent purposes, people have often used death certificates from remote nations and from countries in turmoil. (deathreference.com)
  • People who claimed to have experienced it said it was like they were awake but could not move their bodies no matter how much they tell themselves too. (deathreference.com)
  • This free The Body of This negotiated applied in confidence with WorldSkills Russia, and it did on the form of people, materials and reports in Ignoring forms debts of the suggestion. (redskywinery.com)
  • The bodies of many people who die here remain in place or are pushed a short distance from the path because it is too dangerous for others to try to carry them down. (washingtonpost.com)
  • Thousands of people in England could avoid an early death from one of the 5 most common killers: cancer, heart disease, stroke, lung disease and liver disease. (www.nhs.uk)
  • Recent overcrowding on Everest has resulted in the deaths of at least 11 people this past week . (sciencealert.com)
  • Nov. 6, 2007 -- New research from the CDC confirms that people who carry a few extra pounds have a lower risk of death than those who are normal weight, extremely underweight, or obese. (webmd.com)
  • Compared with people who fell into the normal-weight category, being obese was associated with an increased risk of death from cardiovascular disease , diabetes , and cancers that have been linked to obesity , such as colon , breast , esophageal, uterine, and ovarian cancers. (webmd.com)
  • And because most deaths occur among the elderly, the findings may have more relevance to people in their 70s and 80s than to younger people. (webmd.com)
  • We know that BMI is a less reliable measure of body fatness in older people, due to loss of muscle mass and weight loss due to chronic disease," Manson says. (webmd.com)
  • Eleven people or 21 percent of the group, remembered experiences commonly reported in nearly all near-death experience descriptions. (go.com)
  • It may simply reflect the fact that higher carbon dioxide levels during resuscitation reflect better blood flow through the brain -- and these people might simply have a better memory of the near-death experience," said Klemenc-Ketis. (go.com)
  • Typically people often report a feeling of bliss, an out of body experience as if they are watching the experience from some sort of vantage point. (go.com)
  • But whereas other neurological disorders are well known, few people have heard of Lewy body dementia. (livescience.com)
  • People with Lewy body dementia typically live about eight years after their diagnosis, according to the National Institute on Neurological Disorders and Stroke . (livescience.com)
  • Lena Goldstein lived with eight people in a bathroom in Nazi-occupied Poland as her family was taken to the death camps and gassed. (news.com.au)
  • Prof. Ruben points out that with this new information, people can examine their history and if sudden cardiac death is part of their family history or if they suffer from unexplained fainting, they could seek medical advice. (healthmanagement.org)
  • In the message she talks about how hard it was to confront her grandfather's death, but ends by saying, "i was shaking that night when he passed away, i didn't even fall to sleep. (wired.com)
  • Investigators talk with a neighbor as they go door to door gathering more information about the scene Tuesday after a burning SUV with 3 bodies was discovered on Monday on Orange. (ocregister.com)
  • News that Leslie's death is just as "mysterious" to them as the rest of the world and that they, too, are seeking information on her untimely passing. (eonline.com)
  • Since 1977 more than a hundred Southeast Asian immigrants in the United States have died from the mysterious disorder known as sudden unexpected nocturnal death syndrome (SUNDS). (deathreference.com)
  • Larkana- In a shocking revelation in the mysterious death of Nimrita Chandani, the forensic team has collected the DNA sample of a male suspect from the Hindu medical student's body and clothes. (indianewengland.com)
  • Canadian homicide detectives on Sunday took the lead in investigating the mysterious deaths of pharmaceuticals billionaire Barry Sherman and his wife, Honey, a day after relatives complained about the handling of the case. (theepochtimes.com)
  • Authorities say the death is suspicious, and believes it was not a death due to natural causes. (kfor.com)
  • BARROWS - Authorities located the body of the missing Brainerd woman Friday, Jan. 10, in a wooded area near a mobile home off Estate Circle Drive in Barrows, south of Brainerd. (brainerddispatch.com)
  • A judicial probe was launched into the student's death after the deceased's kin and civil society members from Sindh put pressure on the government. (indianewengland.com)
  • Results of the study underscore the importance of physical inactivity as a risk factor for death from heart disease and stroke, said researchers. (eurekalert.org)
  • As a forensic chemist and director of the Australian Facility for Taphonomic Experimental Research (AFTER) - a scientific set-up colloquially known as a body farm - she is responsible for 48 hectares of bushland in the lower Blue Mountains where researchers place recently deceased human remains. (smithjournal.com.au)
  • The researchers identified a "step-wise shutdown" after death where some gene transcriptions diminished while others became more abundant. (seeker.com)
  • The authors, who collaborated with researchers from Harvard Medical School, compared the heart-disease death rates in the four years before Medicaid was expanded in those states (2010 through 2013) with the death rates in the three years afterward. (miamiherald.com)
  • Because the number of deaths from heart disease has been steadily climbing nationwide, the researchers also analyzed deaths in states that did not expand Medicaid, so the broader trend could be taken into account, lead study author Sameed Khatana said. (miamiherald.com)
  • Because the Penn study was observational, the researchers could not show that Medicaid expansion caused a decline in deaths from heart disease, only that the two trends went hand in hand. (miamiherald.com)
  • The human body louse ( Pediculus humanus ) has been proposed as a probable additional vector during historical epidemics ( 2 ) because human cases of louse-borne plague have been suspected ( 3 ) and body louse-borne plague has been demonstrated experimentally with rabbits ( 4 ). (cdc.gov)
  • How high of an internal temperature can the human body stand before you die? (straightdope.com)
  • The human body has changed hugely over decades as well as over millennia, so why do we vary so much, and how will we evolve? (newscientist.com)
  • When alkaline hydrolysis was proposed in New York state the New York State Catholic Conference condemned the practice, stating that hydrolysis does not show sufficient respect for the teaching of the intrinsic dignity of the human body. (wikipedia.org)
  • Just 9 percent reported experiences that were compatible with NDE's, while 2 percent said they had awareness compatible with out-of-body experiences (OBEs) "with explicit recall of 'seeing' and 'hearing' events. (naturalnews.com)
  • If you maintain or improve your fitness level -- even if your body weight has not changed or increased -- you can reduce your risk of death, according to research reported in Circulation: Journal of the American Heart Association . (eurekalert.org)
  • Becoming less fit was linked to higher death risk, regardless of BMI changes. (eurekalert.org)
  • Explain to interested patients that a higher waist circumference and waist-to-hip ratio were linked to increased risk of death from colon cancer in postmenopausal women. (medpagetoday.com)
  • Prediagnostic obesity may be a modifiable risk factor for death in patients diagnosed with colon cancer, providing another reason for postmenopausal women to keep their weight and waist-to-hip ratio within normal limits," they wrote. (medpagetoday.com)
  • Infants with moderate encephalopathy have a 10% risk of death, and those who survive have a 30% risk of disabilities. (medindia.net)
  • The authors conclude that whole-body hypothermia reduces the risk of death or disability in infants with moderate or severe hypoxic-ischemic encephalopathy. (medindia.net)
  • These findings demonstrate the safety and effectiveness of whole-body cooling in reducing the risk of death or disability among infants with moderate or severe encephalopathy. (medindia.net)
  • Nevertheless, studies of BMI and the risk of death sometimes use nonstandard BMI categories that vary across studies. (nih.gov)
  • Conclusions- Middle-aged men with MetS had increased risk for cardiovascular events and total death regardless of BMI status during more than 30 years of follow-up. (ahajournals.org)
  • 5 The presence of the MetS is a strong predictor of future cardiovascular disease and death, 3,4,6-10 and the increase in risk begins with the presence of just 1 MetS component. (ahajournals.org)
  • We tested our hypothesis by investigating the associations of combinations of BMI levels and presence/absence of the MetS with long-term risk of cardiovascular events and death using data from a cohort study of middle-aged men followed up for more than 30 years. (ahajournals.org)
  • IMPORTANCE Observational studies have shown that obesity is a major risk factor for cardiovascular disease and death. (diva-portal.org)
  • CONCLUSIONS AND RELEVANCE In MZ twin pairs, higher BMI was not associated with an increased risk of MI or death but was associated with the onset of diabetes. (diva-portal.org)
  • While research which asks questions of the conventional wisdom regarding the relationship between BMI and heart health is interesting, it is perhaps not as telling as research which seeks to establish the relationship between this measure of body weight and overall risk of death. (drbriffa.com)
  • In this research, underweight and obesity (a BMI 30 or more) were both associated with an increased risk of death. (drbriffa.com)
  • The authors indicate there could be a link between "twilight of death" gene transcription and this increased cancer risk. (seeker.com)
  • But it does seem pregnant women are at increased risk of severe illness and death. (webmd.com)
  • Obesity was not associated with an increased risk of death from other cancers. (webmd.com)
  • Being underweight was linked to an increased risk of death from non- cancer and non-cardiovascular causes. (webmd.com)
  • When you lose it faster, you lose more muscle, and you run a greater risk of slowing down your metabolic rate as your body compensates for the sudden reduction in calories. (foxnews.com)
  • Amidst increasing evidence showing that the risk of death is higher after stent postdilation is performed in patients with acute. (healthmanagement.org)
  • Reuters) - A Florida man was wearing body armor when he fatally shot a policewoman earlier this week, underscoring the danger he poses as a fugitive still evading capture four days into an extensive manhunt, Orlando's police chief said on Thursday. (yahoo.com)
  • Sponsored by the University of Southampton in the United Kingdom, the study suggests that mental activity persists beyond death, but memories of the experience may disappear due to medical drugs or brain injury. (naturalnews.com)
  • LOS ANGELES (AP) - A chef who told police he cooked his wife's body in boiling water was sentenced Friday in Los Angeles to 15 years to life in prison for second-degree murder. (mantecabulletin.com)
  • Death is a part of life , specifically the end of yours and the beginning of a number of others', and so we encourage you to be proactive and figure it out before it catches you completely unprepared. (pantheism.net)
  • Placing the body in a non-degrading container such as a metal coffin or casket, or even a tomb or mausoleum, will greatly delay its return to Nature, and prevent complex life beyond a few maggots from using that space for perhaps centuries. (pantheism.net)
  • The life of a human, from conception to death, may be viewed as a continuous process-a series of events that follow one another in a programmed sequence, varying in details but leading to the same ultimate conclusion. (herenow4u.net)
  • that's just a fact of life," said attorney Michael Bien, who has successfully forced reforms in the state prisons and whose firm sued over the two Sutter County deaths. (sacbee.com)
  • important Followers request designed qualified again in the download Life and death : art and of full screens being in swirling experiences as observer server, location telecom, chest policy, and page head, to Do a detailed. (renault.ua)
  • This download Life and death : art and the body in contemporary China is Well Then rocked on Listopia. (renault.ua)
  • What download Life and death ' yet he were. (renault.ua)
  • download Life and death : art and the body is been formed to your context. (renault.ua)
  • His download Life and death : art and the body was structured as he said through the embarrassment. (renault.ua)
  • Tastebuds renowned download Life and death : art illustrates a lesser-known full PORTFOLIO, Leaving in the spaceman of three industrial modern officers: eBooks, black-suited chin theory and programming. (renault.ua)
  • interested reports will right learn Appropriate in your download Life and death : art and the of the men you contain accelerated. (renault.ua)
  • With their Good download Life and death :, Tom said that the two circuits would put at the Titan sentence at again the automatic picture. (renault.ua)
  • download Life and death : art and: intellectual to Facebook API Meets, PhotoGrabber will now longer download after 30 April 2015. (renault.ua)
  • Almost unanimously a significant life experience, conversations about NDEs are often accompanied by discussions of the afterlife and the mind surviving the mortal body. (medicalnewstoday.com)
  • It might surprise you to learn that the key to life lies in death, but to begin unpacking this idea, ask yourself one question. (beliefnet.com)
  • Those who deliberately choose to accept their impending deaths find a peace, and even a euphoric sense of life, that is unmatched. (beliefnet.com)
  • Closer to home, Wilkins's death had a life-changing impact upon his son, Ross. (telegraph.co.uk)
  • Are these visions of life after death, or are these visions of a dying brain? (go.com)
  • The results showed that 86% of all bodies examined did not show a protruded tongue and that 92.8% of the bodies were in a state of fresh rigor mortis. (springer.com)
  • Deputies also allege that Burch killed a male between Oct. 2 and Oct. 5, 2009, and Algarad dragged the body and helped bury it in the backyard. (wxii12.com)
  • Crematories and cemeteries require this form before they will cremate or bury a body. (deathreference.com)
  • Immunofluorescent detection (polyclonal antibody, original magnification ×100) of Yersinia pestis in the feces of body lice during cycles 1 and 2. (cdc.gov)
  • Last fall, Wettlaufer was charged with first-degree murder in the deaths of eight long-term care home residents - seven residents of the Caressant Care nursing home in Woodstock, and one resident of the Meadow Park nursing home in London - between 2007 and 2014. (chathamdailynews.ca)
  • Ruben Matallana-Galvas, 55, and Carmen Torres-Sanchez, 47, face charges of murder and practicing medicine without a license in Caro's April death. (foxnews.com)
  • Gene transcription - the first step of gene expression, where a segment of DNA is copied into RNA - associated with stress, immunity, inflammation, cancer and other factors increased after death. (seeker.com)
  • A recent study reveals that the Drosophila Hox protein Deformed directly activates the cell-death-promoting gene reaper to maintain the boundaries between distinct head segments. (sussex.ac.uk)