Bluetongue
Bluetongue virus
Ceratopogonidae
Reoviridae
Cattle Diseases
Sheep
Orbivirus
African horse sickness virus
Ruminants
Insect Vectors
Hemorrhagic Disease Virus, Epizootic
Reverse Genetics
Goats
Deer
Cattle
Serotyping
African Horse Sickness
Viral Core Proteins
Oman
Viral Nonstructural Proteins
RNA, Double-Stranded
Inclusion Bodies, Viral
Hydranencephaly
Neutralization Tests
Vaccines, Marker
Incursion of bluetongue virus into the Okanagan Valley, British Columbia. (1/204)
Bluetongue virus was isolated from a sentinel herd in British Columbia. Virus isolation was by intravenous inoculation of embryonated chicken eggs and subculture in BHK-21 cells. The cytopathic agent was identified as bluetongue virus by electron microscopy and the immunoperoxidase test. The serotype was identified as serotype 11 by virus neutralization. (+info)Malignant catarrhal fever: polymerase chain reaction survey for ovine herpesvirus 2 and other persistent herpesvirus and retrovirus infections of dairy cattle and bison. (2/204)
Using a polymerase chain reaction (PCR) test for sequences of ovine herpesvirus 2 (OHV2), this virus was shown to be significantly associated with sheep-associated malignant catarrhal fever (SA-MCF) in terminal cases of disease in 34 cattle and 53 bison. Ovine herpesvirus 2 was not detected in cattle (38) and bison (10) that succumbed to other diseases. Other persistent herpesviruses, retroviruses, and pestivirus, some of which have been previously isolated from cases of SA-MCF, were not associated with the disease. These included bovine herpesvirus 4 (BHV4), bovine lymphotrophic herpesvirus (BLHV), bovine syncytial virus (BSV, also known as bovine spumavirus), bovine immunodeficiency virus (BIV), and bovine viral diarrhea virus (BVDV). A PCR survey for OHV2 in DNA from individual cow's peripheral blood lymphocytes in 4 dairies showed that the 1 dairy that was in close contact to sheep had a prevalence of OHV2 of 21.3%, whereas the 3 other dairies had no OHV2. Prevalence of the other herpesviruses and retroviruses in the dairy cows was variable, ranging from 2% to 51% for BHV4, 52% to 78.7% for BLHV, and 10% to 34% for BSV. Bovine lymphotrophic herpesvirus and BSV were also found in a few (1-4 of 21 tested) cases of terminal SA-MCF, but BIV and BVDV were not found in either the dairy cows sampled, or in the cases of SA-MCE No significant correlation was found between the presence of any 2 viruses (OHV2, BHV4, BLHV, BSV) in the dairy cows or terminal cases of SA-MCE (+info)Maximal predicted duration of viremia in bluetongue virus-infected cattle. (3/204)
Central to the development of rational trade policies pertaining to bluetongue virus (BTV) infection is determination of the risk posed by ruminants previously exposed to the virus. Precise determination of the maximal duration of infectious viremia is essential to the development of an appropriate quarantine period prior to movement of animals from BTV-endemic to BTV-free regions. The objective of this study was to predict the duration of detectable viremia in BTV-infected cattle using a probabilistic modeling analysis of existing data. Data on the duration of detectable viremia in cattle were obtained from previously published studies. Data sets were created from a large field study of naturally infected cattle in Australia and from experimental infections of cattle with Australian and US serotypes of BTV. Probability distributions were fitted to the pooled empirical data, and the 3 probability distributions that provided the best fit to the data were the gamma, Weibull, and lognormal probability distributions. These asymmetric probability distributions are often well suited for decay processes, such as the time to termination of detectable viremia. The analyses indicated a > 99% probability of detectable BTV viremia ceasing after < or = 9 weeks of infection in adult cattle and after a slightly longer interval in BTV-infected, colostrum-deprived newborn calves. (+info)Occurrence of genetic drift and founder effect during quasispecies evolution of the VP2 and NS3/NS3A genes of bluetongue virus upon passage between sheep, cattle, and Culicoides sonorensis. (4/204)
Bluetongue virus (BTV) is the cause of an insect-transmitted virus infection of ruminants that occurs throughout much of the world. Individual gene segments differ between field strains of BTV; thus, we hypothesized that key viral genes undergo genetic drift during alternating passage of BTV in its ruminant and insect hosts. To test this hypothesis, variation in the consensus sequence and quasispecies heterogeneity of the VP2 and NS3/NS3A genes of a plaque-purified strain of BTV serotype 10 was determined during alternating infection of vector Culicoides sonorensis and a sheep and calf. Consensus sequences were determined after reverse transcriptase-nested PCR amplification of viral RNA directly from ruminant blood and homogenized insects, and quasispecies heterogeneity was determined by the sequencing of clones derived from directly amplified viral RNA. Comparison of these sequences to those of the original BTV inoculum used to initiate the cycle of BTV infection demonstrated, for the first time, that individual BTV gene segments evolve independently of one another by genetic drift in a host-specific fashion, generating quasispecies populations in both ruminant and insect hosts. Furthermore, a unique viral variant was randomly ingested by C. sonorensis insects that fed on a sheep with low-titer viremia, thereby fixing a novel genotype by founder effect. Thus, we conclude that genetic drift and founder effect contribute to diversification of individual gene segments of field strains of BTV. (+info)Studies on the epidemiology of bluetongue virus in China. (5/204)
Sentinel herds of large ruminants were established at five centres in Yunnan Province, Peoples Republic of China, between 1995 and 1997. The application of a sensitive antigen capture ELISA to facilitate virus isolation procedures led to the isolation of 108 strains of bluetongue (BLU) virus. Serotypes isolated included types 1, 2, 3, 4, 9, 11, 12, 15, 16, 21 and 23. Virus transmission occurred over a period of 1-3 months at each of the four positive sites, giving an overall BLU virus transmission period for the province of 5 months, from early June to early November. The greatest level of transmission took place in July and August. The duration of viraemia in individual animals varied from 1 to 7 weeks, with a mean calculated for each serotype between 6 and 20 days. The study represents the first detailed investigation of the epidemiology of BLU in China utilizing sentinel herds. (+info)The role of endothelial cell-derived inflammatory and vasoactive mediators in the pathogenesis of bluetongue. (6/204)
Bluetongue is an insect-transmitted disease of sheep and wild ruminants that is caused by bluetongue virus (BTV). Cattle are asymptomatic reservoir hosts of BTV. Infection of lung microvascular endothelial cells (ECs) is central to the pathogenesis of BTV infection of both sheep and cattle, but it is uncertain as to why sheep are highly susceptible to BTV-induced microvascular injury, whereas cattle are not. Thus, to better characterize the pathogenesis of bluetongue, the transcription of genes encoding a variety of vasoactive and inflammatory mediators was quantitated in primary ovine lung microvascular ECs (OLmVECs) exposed to BTV and/or inflammatory mediators. BTV infection of OLmVECs increased the transcription of genes encoding interleukin- (IL) 1 and IL-8, but less so IL-6, cyclooxygenase-2, and inducible nitric oxide synthase. In contrast, we previously have shown that transcription of genes encoding all of these same mediators is markedly increased in BTV-infected bovine lung microvascular ECs and that BTV-infected bovine ECs produce substantially greater quantities of prostacyclin than do sheep ECs. Thus, sheep and cattle were experimentally infected with BTV to further investigate the role of EC-derived vasoactive mediators in the pathogenesis of bluetongue. The ratio of thromboxane to prostacyclin increased during BTV infection of both sheep and cattle, but was significantly greater in sheep (P = 0.001). Increases in the ratio of thromboxane to prostacyclin, indicative of enhanced coagulation, coincided with the occurrence of clinical manifestations of bluetongue in BTV-infected sheep. The data suggest that inherent species-specific differences in the production and activities of EC-derived mediators contribute to the sensitivity of sheep to BTV-induced microvascular injury. (+info)A possible overwintering mechanism for bluetongue virus in the absence of the insect vector. (7/204)
Bluetongue virus (BTV) and several other Orbivirus species are transmitted between mammalian hosts via bites from adults of certain species of Culicoides midges. However, BTV can survive for 9-12 months (typically during the winter), in the absence of adult vectors, with no detectable cases of viraemia, disease or seroconversion in the host. The survival of the virus from one 'vector season' to the next is called 'overwintering' but the mechanism involved is not fully understood. It is demonstrated that BTV can persistently infect ovine gammadelta T-cells in vitro, a process that may also occur during infection and viraemia in mammalian hosts, thus providing a mechanism for virus persistence. Interaction of persistently BTV-infected gammadelta T-cells with antibody to the gammadelta T-cell-specific surface molecule WC-1 resulted in conversion to a lytic infection and increased virus release. Skin fibroblasts induce a similar conversion, indicating that they express a counter ligand for WC-1. Feeding of Culicoides midges induces skin inflammation, which is accompanied by recruitment of large numbers of activated gammadelta T-cells. The interaction of persistently infected gammadelta T-cells with skin fibroblasts would result in increased virus production at 'biting sites', favouring transmission to the insect vector. This suggested mechanism might also involve up-regulation of the WC-1 ligand at inflamed sites. It has been shown previously that cleavage of virus surface proteins by protease enzymes (which may also be associated with inflammation) generates infectious subvirus particles that have enhanced infectivity (100 times) for the insect vector. (+info)Competitive ELISA for serodiagnosis of bluetongue: evaluation of group-specific monoclonal antibodies and expressed VP7 antigen. (8/204)
The performance of 2 competitive enzyme-linked immunosorbent assays (C-ELISA) was compared with the reference C-ELISA I for the detection of antibodies to bluetongue virus (BTV). One of the assays (C-ELISA II) used a group-specific monoclonal antibody (MAb) to BTV, obtained from the American Type Culture Collection (8A3B-6) and tissue culture (TC)-derived BTV antigen (Ag), and the other assay (C-ELISA III) used BTV core protein VP7 (expressed in yeast) and the reference MAb (Pirbright Laboratory, 3-17-A3). Test sera were obtained by sequential blood samples from 22 calves, each inoculated with a different serotype (T) of BTV (South African [SA] T-1-T-16 and T-18-T-20 and USA T-11, T-13, and T-17). Sera were also obtained from 4 calves and 4 sheep inoculated with USA BTV T-10 and from several groups of calves exposed to single or multiple doses of epizootic hemorrhagic disease virus (EHDV) T-1-T-4 grown in TC (BHK-21) or suckling mouse brain (SMB). A total of 618 bovine and ovine field sera collected from BT-free and BT-endemic areas were also tested. The C-ELISA III was more sensitive than the C-ELISA II in the detection of anti-BTV antibody in sera from cattle and sheep early after infection with BTV. Seroconversion was demonstrated by the 3 C-ELISAs in all animals inoculated with BTV by 20 days postinfection (DPI), except in calves that received SA T-3 or USA T-13, which became positive at 40 DPI.(ABSTRACT TRUNCATED AT 250 WORDS) (+info)Bluetongue is a viral disease that affects livestock, particularly ruminants such as cattle, sheep, and goats. The disease is caused by the Bluetongue virus (BTV), which is transmitted to animals through the bite of an infected midge or other biting insect. Symptoms of bluetongue can vary depending on the species and age of the animal, but they typically include fever, loss of appetite, and difficulty swallowing. In severe cases, the disease can lead to lameness, difficulty breathing, and even death. Bluetongue is a notifiable disease in many countries, which means that outbreaks must be reported to the relevant authorities. Control measures for bluetongue include vaccination of susceptible animals, vector control (such as the use of insecticides to reduce the number of biting insects), and movement restrictions to prevent the spread of the virus.
Bluetongue virus (BTV) is a type of orbivirus that primarily affects ruminants, such as cattle, sheep, and goats. It is transmitted by midges and other biting insects, and can cause a range of clinical signs, including fever, lethargy, and mouth ulcers. In severe cases, BTV can lead to death. The virus is also capable of infecting humans, although human cases are rare. BTV is considered a significant veterinary and economic concern, as it can cause significant losses in livestock production. There is no specific treatment for BTV infection, and prevention measures typically involve controlling the vector population and vaccination of susceptible animals.
Ceratopogonidae is a family of insects commonly known as biting midges or no-see-ums. These small, fast-flying insects are found worldwide and are known for their ability to bite humans and animals, causing irritation and discomfort. In the medical field, Ceratopogonidae are considered a nuisance pest and can be a vector for diseases such as West Nile virus and equine encephalitis. They are also a concern for people with allergies or sensitivities to their bites, which can cause redness, swelling, and itching. Treatment for bites typically involves the use of antihistamines and topical creams to relieve symptoms.
Cattle diseases refer to any illness or condition that affects cattle, which are domesticated animals commonly raised for meat, milk, and other products. These diseases can be caused by a variety of factors, including bacteria, viruses, fungi, parasites, and environmental conditions. In the medical field, cattle diseases are typically studied and treated by veterinarians who specialize in animal health. Some common cattle diseases include bovine respiratory disease (BRD), Johne's disease, foot-and-mouth disease, and mastitis. These diseases can have significant economic impacts on farmers and the cattle industry, as they can lead to decreased productivity, increased mortality rates, and the need for costly treatments. To prevent and control cattle diseases, veterinarians and farmers may use a variety of strategies, including vaccination, proper nutrition and hygiene, and the use of antibiotics and other medications when necessary. Additionally, monitoring and surveillance efforts are often implemented to detect and respond to outbreaks of new or emerging diseases.
Reoviridae infections refer to a group of viral infections caused by viruses belonging to the family Reoviridae. These viruses are non-enveloped, double-stranded RNA viruses that can infect a wide range of hosts, including humans, animals, and plants. Reoviridae infections can cause a variety of clinical manifestations, depending on the specific virus and the host infected. In humans, reovirus infections can cause mild to severe respiratory tract infections, such as the common cold, bronchitis, and pneumonia. Other clinical manifestations of reovirus infections in humans include diarrhea, encephalitis, meningitis, and myocarditis. Reovirus infections can also cause disease in animals, including cattle, sheep, pigs, and poultry. In animals, reovirus infections can cause respiratory tract infections, enteritis, and abortion. Diagnosis of reovirus infections is typically made through laboratory testing, such as viral culture, serology, and molecular testing. Treatment of reovirus infections is generally supportive, with management of symptoms and complications as needed. Prevention of reovirus infections involves measures such as vaccination, hygiene, and good sanitation practices. Vaccines are available for some animal species, but there are currently no vaccines for humans.
African horse sickness virus (AHSV) is a highly contagious viral disease that affects equids (horses, donkeys, mules, and zebras) and other members of the family Equidae. The virus is transmitted by midges (Culicoides spp.) and can cause a range of clinical signs, including fever, lethargy, loss of appetite, and muscle weakness. In severe cases, the disease can lead to hemorrhaging, shock, and death. There is no known cure for AHSV, and prevention is the best approach, which includes vaccination, insect control, and quarantine measures. The virus is found in sub-Saharan Africa, the Middle East, and parts of Europe, and is considered a significant threat to the equine industry in these regions.
In the medical field, "Sheep Diseases" refers to a group of illnesses and infections that affect sheep, which are domesticated ruminant mammals. These diseases can be caused by various agents, including bacteria, viruses, fungi, and parasites. Some common sheep diseases include: 1. Scrapie: a fatal neurodegenerative disease caused by a prion protein. 2. Bluetongue: a viral disease that affects the mouth and tongue of sheep and other ruminants. 3. Foot-and-mouth disease: a highly contagious viral disease that affects the mouth, feet, and udder of sheep and other cloven-hoofed animals. 4. Pneumonia: a respiratory disease caused by bacteria or viruses that can be fatal in severe cases. 5. Eimeriosis: a parasitic disease caused by coccidia that affects the digestive system of sheep. 6. Johne's disease: a chronic bacterial infection that affects the digestive system of sheep and other ruminants. 7. Coccidiosis: a parasitic disease caused by coccidia that affects the digestive system of sheep. 8. Anthrax: a bacterial disease that can affect the skin, respiratory system, and digestive system of sheep. 9. Leptospirosis: a bacterial disease that can affect the kidneys and liver of sheep. 10. Brucellosis: a bacterial disease that can affect the reproductive system of sheep and other ruminants. Prevention and control of sheep diseases are essential to maintain the health and productivity of sheep populations. This can be achieved through vaccination, proper nutrition, hygiene, and management practices.
In the medical field, the term "deer" typically refers to the animal commonly known as the deer, which is a large herbivorous mammal found in various parts of the world. In some cases, the term "deer" may also be used to refer to specific medical conditions or diseases that are associated with deer or are caused by deer. For example, the term "deer tick" may be used to refer to the tick species that can transmit Lyme disease, which is a bacterial infection that can affect humans and other animals. In addition, the term "deer" may also be used in the context of medical research or drug development. For example, deer antler velvet, which is a substance produced by deer antlers during their growth phase, has been studied for its potential therapeutic effects and is sometimes used as a dietary supplement.
In the medical field, the term "cattle" refers to large domesticated animals that are raised for their meat, milk, or other products. Cattle are a common source of food and are also used for labor in agriculture, such as plowing fields or pulling carts. In veterinary medicine, cattle are often referred to as "livestock" and may be treated for a variety of medical conditions, including diseases, injuries, and parasites. Some common medical issues that may affect cattle include respiratory infections, digestive problems, and musculoskeletal disorders. Cattle may also be used in medical research, particularly in the fields of genetics and agriculture. For example, scientists may study the genetics of cattle to develop new breeds with desirable traits, such as increased milk production or resistance to disease.
African Horse Sickness (AHS) is a viral disease that primarily affects horses and other equids, but can also infect other animals such as zebras and donkeys. The virus is transmitted by midges, which acquire the virus by feeding on infected animals and then transmit it to other animals through their saliva. Symptoms of AHS can vary depending on the severity of the infection, but typically include high fever, loss of appetite, weakness, and difficulty breathing. In severe cases, the disease can lead to paralysis, coma, and death. AHS is considered one of the most serious diseases affecting horses, and is considered a notifiable disease in many countries. There is no cure for AHS, and prevention is the best way to control the disease. This includes measures such as vaccination, vector control, and quarantine of infected animals.
In the medical field, viral core proteins refer to the internal proteins that are essential for the replication and survival of a virus. These proteins are typically found within the viral capsid, which is the protein shell that surrounds the viral genome. The viral core proteins play a crucial role in the viral life cycle by facilitating the replication of the viral genome and the assembly of new virus particles. They may also be involved in protecting the viral genome from degradation or preventing the host immune system from recognizing and eliminating the virus. Examples of viral core proteins include the core protein of the hepatitis B virus, which is essential for the replication of the viral genome, and the core protein of the human immunodeficiency virus (HIV), which plays a role in the assembly of new virus particles. Understanding the structure and function of viral core proteins is important for the development of antiviral drugs and vaccines, as well as for understanding the pathogenesis of viral infections.
In the medical field, capsid proteins refer to the proteins that make up the outer shell of a virus. The capsid is the protective layer that surrounds the viral genome and is responsible for protecting the virus from the host's immune system and other environmental factors. There are two main types of capsid proteins: structural and non-structural. Structural capsid proteins are the proteins that make up the visible part of the virus, while non-structural capsid proteins are involved in the assembly and maturation of the virus. The specific function of capsid proteins can vary depending on the type of virus. For example, some capsid proteins are involved in attaching the virus to host cells, while others are involved in protecting the viral genome from degradation. Understanding the structure and function of capsid proteins is important for the development of antiviral drugs and vaccines, as well as for understanding the pathogenesis of viral infections.
Antibodies, viral, are proteins produced by the immune system in response to a viral infection. They are also known as immunoglobulins or antibodies. Viral antibodies are specific to a particular virus and can help to neutralize and eliminate the virus from the body. They are typically detected in the blood or other bodily fluids using laboratory tests, such as enzyme-linked immunosorbent assays (ELISAs) or immunofluorescence assays. The presence of viral antibodies can be used as a diagnostic tool to confirm a viral infection or to determine the immune status of an individual.
In the medical field, "Goat Diseases" refers to a wide range of illnesses and conditions that can affect goats. These diseases can be caused by various factors, including bacteria, viruses, fungi, parasites, and environmental factors. Some common goat diseases include: 1. Caprine arthritis encephalitis virus (CAEV): A viral disease that affects the central nervous system and joints of goats. 2. Q fever: A bacterial disease that can cause fever, pneumonia, and other respiratory symptoms in goats. 3. Johne's disease: A bacterial disease that affects the digestive system of goats and can cause diarrhea, weight loss, and other symptoms. 4. Coccidiosis: A parasitic disease that affects the digestive system of goats and can cause diarrhea, weight loss, and other symptoms. 5. Mycoplasma agalactiae: A bacterial disease that can cause mastitis (inflammation of the mammary glands) in goats. 6. Scrapie: A fatal neurodegenerative disease that affects the central nervous system of goats. 7. Bluetongue: A viral disease that affects the mouth and tongue of goats and can cause fever, swelling, and other symptoms. 8. Foot-and-mouth disease: A viral disease that affects the mouth and feet of goats and can cause fever, blisters, and other symptoms. 9. Anthrax: A bacterial disease that can cause fever, skin ulcers, and other symptoms in goats. 10. Rift Valley fever: A viral disease that can cause fever, muscle pain, and other symptoms in goats. These are just a few examples of the many goat diseases that can affect goats. It is important for goat owners to be aware of the common diseases in their area and to take steps to prevent and treat them.
Viral nonstructural proteins (NSPs) are proteins that are not part of the viral capsid or envelope, but are instead synthesized by the virus after it has entered a host cell. These proteins play important roles in the replication and assembly of the virus, as well as in evading the host immune system. NSPs can be classified into several functional groups, including proteases, helicases, polymerases, and methyltransferases. For example, the NSP1 protein of the influenza virus is a protease that cleaves host cell proteins to create a favorable environment for viral replication. The NSP3 protein of the hepatitis C virus is a helicase that unwinds the viral RNA genome to allow for transcription and replication. NSPs can also be targeted by antiviral drugs, as they are often essential for viral replication. For example, the protease inhibitors used to treat HIV target the viral protease enzyme, which is an NSP. Similarly, the NS5B polymerase inhibitors used to treat hepatitis C target the viral polymerase enzyme, which is also an NSP. Overall, NSPs play important roles in the life cycle of viruses and are an important target for antiviral therapy.
RNA, Double-Stranded refers to a type of RNA molecule that consists of two complementary strands of nucleotides held together by hydrogen bonds. In contrast to single-stranded RNA, which has only one strand of nucleotides, double-stranded RNA (dsRNA) is more stable and can form more complex structures. Double-stranded RNA is commonly found in viruses, where it serves as the genetic material for the virus. It is also found in some cellular processes, such as the processing of messenger RNA (mRNA) and the regulation of gene expression. Double-stranded RNA can trigger an immune response in cells, which is why it is often targeted by antiviral drugs and vaccines. Additionally, some researchers are exploring the use of dsRNA as a tool for gene editing and gene therapy.
RNA, Viral refers to the genetic material of viruses that are composed of RNA instead of DNA. Viral RNA is typically single-stranded and can be either positive-sense or negative-sense. Positive-sense RNA viruses can be directly translated into proteins by the host cell's ribosomes, while negative-sense RNA viruses require a complementary positive-sense RNA intermediate before protein synthesis can occur. Viral RNA is often encapsidated within a viral capsid and can be further protected by an envelope made of lipids and proteins derived from the host cell. RNA viruses include a wide range of pathogens that can cause diseases in humans and other organisms, such as influenza, hepatitis C, and SARS-CoV-2 (the virus responsible for COVID-19).
Hydranencephaly is a rare congenital brain abnormality characterized by the absence of most of the brain tissue in the posterior fossa, leaving behind a cystic cavity filled with cerebrospinal fluid. The term "hydranencephaly" comes from the Greek words "hydro," meaning water, and "encephaly," meaning brain. In hydranencephaly, the brainstem and cerebellum are usually preserved, but the cerebral hemispheres are severely underdeveloped or absent. This can result in a range of symptoms, including seizures, difficulty feeding, and problems with movement and coordination. In severe cases, hydranencephaly can be fatal. Hydranencephaly is usually diagnosed prenatally through ultrasound or magnetic resonance imaging (MRI) scans. Treatment options may include surgery to relieve pressure on the brain or to remove any cysts that may be present. However, there is no cure for hydranencephaly, and the prognosis for affected individuals is generally poor.
In the medical field, "Vaccines, Marker" refers to a type of vaccine that uses a specific marker or antigen to stimulate an immune response in the body. A marker is a substance that is unique to a particular disease or condition, and it can be used to identify or track the presence of that disease or condition. In the context of vaccines, a marker is used to identify a specific antigen or protein that is associated with a particular disease or condition. When a vaccine containing a specific marker is administered to a person, the immune system recognizes the marker as foreign and mounts an immune response against it. This immune response can help to protect the person from developing the disease or condition that the marker is associated with. For example, the human papillomavirus (HPV) vaccine contains markers that are specific to certain strains of HPV. When the vaccine is administered, the immune system recognizes the HPV markers and mounts an immune response against them, which can help to protect the person from developing HPV-related diseases such as cervical cancer. Overall, vaccines that use markers are an important tool in preventing and controlling the spread of infectious diseases.
In the medical field, a capsid refers to the protein shell that surrounds and encloses the genetic material (either DNA or RNA) of a virus. The capsid is responsible for protecting the viral genome and facilitating its entry into host cells. Viruses can have different types of capsids, which can be classified based on their shape and structure. For example, some viruses have simple spherical capsids, while others have more complex shapes such as helical or polyhedral capsids. The capsid can also play a role in viral pathogenesis, as it can interact with host cell receptors and trigger immune responses. In some cases, the capsid can be modified or altered by the virus to evade the host immune system and enhance its ability to infect cells.
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House of Commons Hansard Ministerial Statements for 26 Nov 2008 (pt 0001)
Virus12
- Bluetongue is an acute, subacute, and possible chronic virus disease of wild and domestic ruminants (3,10). (cdc.gov)
- but pathogenesis studies with C. variipennis reconfirmed the unlikelyhood of transovarian transmission of bluetongue virus (39). (cdc.gov)
- Few reports of clinical Bluetongue virus (BTV) infections have been described in dogs. (scielo.org.za)
- Bluetongue (BT) is a vector-borne World Organization for Animal Health (founded as the OIE) listed disease, primarily affecting ruminants, caused by the Bluetongue virus (BTV), which belongs to the genus Orbivirus of the family Reoviridae (OIE 2019). (scielo.org.za)
- This page lists the EVAg products having been related to the "Bluetongue" virus name. (european-virus-archive.com)
- The present work was aimed to know the serotypes of bluetongue virus (BTV) circulating in western region of Cuba. (edu.cu)
- To estimate seroprevalence of bluetongue virus (BTV) and the geographic distribution of seropositive cattle herds in Illinois and western Indiana. (singerepidemiology.org)
- Bluetongue virus antibodies were distributed heterogeneously in this region. (singerepidemiology.org)
- Replication-Deficient Particles: New Insights into the Next Generation of Bluetongue Virus Vaccines. (sciensano.be)
- Bluetongue virus ( BTV ) is endemic in many parts of the world, often causing severe hemorrhagic disease in livestock. (sciensano.be)
- Classical vaccines that afford protection against bluetongue virus, the etiological agent, are not free from secondary and undesirable effects. (sciensano.be)
- Serious animal pathogens include bluetongue virus of sheep and African horse sickness virus. (medscape.com)
Epidemiology1
- Title : Bluetongue Epidemiology in the European Union Personal Author(s) : Saegerman, Claude;Berkvens, Dirk;Mellor, Philip S. (cdc.gov)
Viral1
- Bluetongue (BT) is an insect-transmitted viral disease of ruminant species. (edu.cu)
Animal2
- I am urging our livestock farmers to keep an eye out for any signs of the disease and report any suspicions to their vet and the Animal and Plant Health Agency immediately, so we can work together to reduce the possible spread of Bluetongue this summer. (thebeefsite.com)
- Bluetongue (BT) is a reportable disease of considerable socioeconomic concern and of major importance in the international trade of animals and animal products. (cdc.gov)
Disease2
- There is a high risk of an outbreak of Bluetongue (BTV-8) towards the end of the summer as a result of infected midges being blown across the English Channel from France, where the disease is present. (thebeefsite.com)
- Bluetongue (BT) is a debilitating and in many cases lethal disease that affects ruminants of economic importance. (sciensano.be)
Isolated and char1
- A bluetongue virus strain was isolated and characterized as serotype 8. (cdc.gov)
Cases of bluetongue2
Cattle7
- Twenty-one animals (16 cattle and 5 sheep) showing clinical signs suggestive of bluetongue were sampled by the Federal Agency for the Safety of the Food Chain on August 18, 2006, at 11 farms in northeastern Belgium. (cdc.gov)
- However, they are exclusive in that only white-tailed deer are affected, despite the fact that bluetongue is a well-known ailment of innocent cattle and goats, further influencing deer. (brusselstribunal.org)
- AUSTRALIA - A case of bluetongue has been discovered in a sentinel herd of cattle in Australia. (thebeefsite.com)
- Epidemiological analysis of the 2006 bluetongue virus serotype 8 epidemic in northwestern Europe: nature and severity of disease in sheep and cattle. (vin.com)
- To estimate seroprevalence of bluetongue virus (BTV) and the geographic distribution of seropositive cattle herds in Illinois and western Indiana. (singerepidemiology.org)
- Bluetongue virus infection in cattle: serosurvey and its associated risk factors. (bvsalud.org)
- Moreover, cattle contacted with other animals (OR=1.40, 95%CI 0.94-2.10), with history of abortion (OR=4.88, 95%CI 3.14-7.59), and those living with presence of insects (OR=12.34, 95%CI 8-19.30) were more likely to be infected with bluetongue (BT). (bvsalud.org)
Epizootic1
- European zoos are in a unique position to contribute to knowledge on disease caused by bluetongue virus subtype 8 (BTV8) in non-domestic ruminants, as they house and monitor a wide range of ruminant species that can be assumed to have been naïve to infection prior to the BTV8 epizootic in northwestern Europe that began in August 2006. (vin.com)
Reoviridae2
Virus infection1
- Bluetongue virus infection of ruminants is often subclinical, but outbreaks of severe disease occur regularly at the upper and lower limits of the virus's global range, where infection is distinctly seasonal. (nih.gov)
Clinical3
- From August 19, 2006, to September 14, 2006, the study farms were screened for animals with clinical signs of bluetongue. (cdc.gov)
- Specifically, some vaccinated sheep developed signs of clinical bluetongue with fever, facial oedema and lameness. (visavet.es)
- The presence of Bluetongue virus (BTV) in Northern Australia poses an ongoing threat for animal health and although clinical disease has not been detected in livestock, it limits export of livestock from the infected areas. (edu.au)
Antibodies1
- Bluetongue virus antibodies were distributed heterogeneously in this region. (singerepidemiology.org)
Ruminants1
- Bluetongue is an acute, subacute, and possible chronic virus disease of wild and domestic ruminants (3,10). (cdc.gov)
Detection2
- The development of a real-time reverse transcription-polymerase chain reaction (rRT-PCR) assay using TaqMan technology for the pan detection of bluetongue virus (BTV). (medscape.com)
- Development and Evaluation of Real Time RT-PCR Assays for Detection and Typing of Bluetongue Virus. (medscape.com)
Belgium1
- Bluetongue has emerged recently in Belgium. (cdc.gov)
Sheep2
- Stock and lamb are seldom significantly laid low with EHD , even though sheep may be pretty at risk of Bluetongue. (brusselstribunal.org)
- Bluetongue virus (BTV) is a vector-borne virus that primarily affects sheep . (bvsalud.org)
Chronic1
- End/bluetongue are distinct illnesses from the chronic losing ailment. (brusselstribunal.org)
Transmission1
- but pathogenesis studies with C. variipennis reconfirmed the unlikelyhood of transovarian transmission of bluetongue virus (39). (cdc.gov)
Search1
- For example, by grouping all Arbovirus Infections (African Horse Sickness, Bluetongue, Dengue, Yellow Fever, etc.) together under the general term "Arbovirus Infections," a literature search system can take your search of arbovirus infections and automatically include terms for all the specific types of arbovirus infections (which you may not even be aware of) in your search. (nih.gov)
Europe2
- In EFSA scientific report: Epidemiological analysis of the 2006 bluetongue virus serotype 8 epidemic in northwestern Europe. (vin.com)
- During a hot summer, bluetongue virus invades northern Europe. (medscape.com)
Netherlands1
- An outbreak of bluetongue was reported and confirmed in the Netherlands on August 17, 2006 ( 2 ). (cdc.gov)
AUSTRALIA1
- To monitor Bluetongue virus (BTV) activity in northern and eastern Australia the National Arbovirus Monitoring Program (NAMP) collects data from a network of sentinel herds. (edu.au)