The urea concentration of the blood stated in terms of nitrogen content. Serum (plasma) urea nitrogen is approximately 12% higher than blood urea nitrogen concentration because of the greater protein content of red blood cells. Increases in blood or serum urea nitrogen are referred to as azotemia and may have prerenal, renal, or postrenal causes. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.
Pathological processes of the KIDNEY or its component tissues.
An examination of chemicals in the blood.
Acute kidney failure resulting from destruction of EPITHELIAL CELLS of the KIDNEY TUBULES. It is commonly attributed to exposure to toxic agents or renal ISCHEMIA following severe TRAUMA.
An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.
The process in certain BACTERIA; FUNGI; and CYANOBACTERIA converting free atmospheric NITROGEN to biologically usable forms of nitrogen, such as AMMONIA; NITRATES; and amino compounds.
A biochemical abnormality referring to an elevation of BLOOD UREA NITROGEN and CREATININE. Azotemia can be produced by KIDNEY DISEASES or other extrarenal disorders. When azotemia becomes associated with a constellation of clinical signs, it is termed UREMIA.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.
Stable nitrogen atoms that have the same atomic number as the element nitrogen, but differ in atomic weight. N-15 is a stable nitrogen isotope.
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Excision of kidney.
Mercury chloride (HgCl2). A highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Elements of limited time intervals, contributing to particular results or situations.
Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.
Proteins obtained from foods. They are the main source of the ESSENTIAL AMINO ACIDS.
Inorganic compounds that contain nitrogen as an integral part of the molecule.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Synthetic or natural substances which are given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent.
The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. They act as DIURETICS. Excess use is associated with HYPOKALEMIA and HYPERGLYCEMIA.
Foodstuff used especially for domestic and laboratory animals, or livestock.
The circulation of nitrogen in nature, consisting of a cycle of biochemical reactions in which atmospheric nitrogen is compounded, dissolved in rain, and deposited in the soil, where it is assimilated and metabolized by bacteria and plants, eventually returning to the atmosphere by bacterial decomposition of organic matter.
Nitrogen oxide (NO2). A highly poisonous gas. Exposure produces inflammation of lungs that may only cause slight pain or pass unnoticed, but resulting edema several days later may cause death. (From Merck, 11th ed) It is a major atmospheric pollutant that is able to absorb UV light that does not reach the earth's surface.
The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.
Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)
A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A bile pigment that is a degradation product of HEME.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
The measurement of an organ in volume, mass, or heaviness.
Glucose in blood.
Nutritional physiology of animals.
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.
A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.
The dialdehyde of malonic acid.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Inflammation of any part of the KIDNEY.
Tests used in the analysis of the hemic system.
The consumption of edible substances.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The circulation of the BLOOD through the vessels of the KIDNEY.
The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.
The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.
Nitrogenous products of NITRIC OXIDE synthases, ranging from NITRIC OXIDE to NITRATES. These reactive nitrogen intermediates also include the inorganic PEROXYNITROUS ACID and the organic S-NITROSOTHIOLS.
Examination of urine by chemical, physical, or microscopic means. Routine urinalysis usually includes performing chemical screening tests, determining specific gravity, observing any unusual color or odor, screening for bacteriuria, and examining the sediment microscopically.
Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.
A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.
Increase in BODY WEIGHT over existing weight.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
A polypeptide that is secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Growth hormone, also known as somatotropin, stimulates mitosis, cell differentiation and cell growth. Species-specific growth hormones have been synthesized.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
Use of plants or herbs to treat diseases or to alleviate pain.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.
Regular course of eating and drinking adopted by a person or animal.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.
State of the body in relation to the consumption and utilization of nutrients.
A disease or state in which death is possible or imminent.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Health care provided to a critically ill patient during a medical emergency or crisis.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Inorganic oxides that contain nitrogen.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
Portable peritoneal dialysis using the continuous (24 hours a day, 7 days a week) presence of peritoneal dialysis solution in the peritoneal cavity except for periods of drainage and instillation of fresh solution.
The process of breakdown of food for metabolism and use by the body.
Disease having a short and relatively severe course.
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A family of signal transducing adaptor proteins that control the METABOLISM of NITROGEN. They are primarily found in prokaryotes.
An enzyme that catalyzes the conversion of urea and water to carbon dioxide and ammonia. EC 3.5.1.5.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).
Agents that promote the excretion of urine through their effects on kidney function.
Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.
Method of analyzing chemicals using automation.
Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.
Solutions prepared for hemodialysis. The composition of the pre-dialysis solution may be varied in order to determine the effect of solvated metabolites on anoxia, malnutrition, acid-base balance, etc. Of principal interest are the effect of the choice of buffers (e.g., acetate or carbonate), the addition of cations (Na+, K+, Ca2+), and addition of carbohydrates (glucose).

Effect of fasting on temporal variation in the nephrotoxicity of amphotericin B in rats. (1/1427)

Evidence for temporal variation in the nephrotoxicity of amphotericin B was recently reported in experimental animals. The role of food in these variations was determined by studying the effect of a short fasting period on the temporal variation in the renal toxicity of amphotericin B. Twenty-eight normally fed and 28 fasted female Sprague-Dawley rats were used. Food was available ad libitum to the fed rats, while the fasted animals were fasted 12 h before and 24 h after amphotericin B injection to minimize stress for the animals. Water was available ad libitum to both groups of rats, which were maintained on a 14-h light, 10-h dark regimen (light on at 0600 h). Renal toxicity was determined by comparing the levels of excretion of renal enzyme and the serum creatinine and blood urea nitrogen (BUN) levels at the time of the maximal (0700 h) or the minimal (1900 h) nephrotoxicity after the intraperitoneal administration of a single dose of dextrose (5%; control group) or amphotericin B (50 mg/kg of body weight; treated group) to the rats. The nephrotoxicities obtained after amphotericin B administration at both times of day were compared to the nephrotoxicities observed for time-matched controls. In fed animals, the 24-h urinary excretion of N-acetyl-beta-D-glucosaminidase and beta-galactosidase was significantly higher when amphotericin B was injected at 0700 and 1900 h. The excretion of these two enzymes was reduced significantly (P < 0.05) in fasting rats, and this effect was larger at 0700 h (P < 0.05) than at 1900 h. The serum creatinine level was also significantly higher (P < 0.05) in fed animals treated at 0700 h than in fed animals treated at 1900 h. Fasting reduced significantly (P < 0.05) the increase in the serum creatinine level, and this effect was larger in the animals treated at 0700 h. Similar data were obtained for BUN levels. Amphotericin B accumulation was significantly higher (P < 0.05) in the renal cortexes of fed rats than in those of fasted animals, but there was no difference according to the time of injection. These results demonstrated that fasting reduces the nephrotoxicity of amphotericin B and that food availability is of crucial importance in the temporal variation in the renal toxicity of amphotericin B in rats.  (+info)

Sustained induction of fetal hemoglobin by pulse butyrate therapy in sickle cell disease. (2/1427)

High levels of fetal hemoglobin (Hb F) protect from many of the complications of sickle cell disease and lead to improved survival. Butyrate and other short chain fatty acids were previously shown to increase Hb F production in erythroid cells in vitro and in animal models in vivo. However, butyrates are also known to inhibit the proliferation of many cell types, including erythroid cells. Experience with the use of butyrate in animal models and in early clinical trials demonstrated that the Hb F response may be lost after prolonged administration of high doses of butyrate. We hypothesized that this loss of response may be a result of the antiproliferative effects of butyrate. We designed a regimen consisting of intermittent or pulse therapy in which butyrate was administered for 4 days followed by 10 to 24 days with no drug exposure. This pulse regimen induced fetal globin gene expression in 9 of 11 patients. The mean Hb F in this group increased from 7.2% to 21.0% (P <.002) after intermittent butyrate therapy for a mean duration of 29.9 weeks. This was associated with a parallel increase in the number of F cells and F reticulocytes. The total hemoglobin levels also increased from a mean of 7.8 g/dL to a mean of 8.8 g/dL (P <.006). The increased levels of Hb F were sustained in all responders, including 1 patient who has been on pulse butyrate therapy for more than 28 months. This regimen, which resulted in a marked and sustained increase in Hb F levels in more than two thirds of the adult sickle cell patients enrolled in this study, was well tolerated without adverse side effects. These encouraging results require confirmation along with an appropriate evaluation of clinical outcomes in a larger number of patients with sickle cell disease.  (+info)

Comparative nephrotoxicities of netilmicin and gentamicin in rats. (3/1427)

The relative nephrotoxicities of netilmicin (Sch 20569) and gentamicin were compared in rats at doses of 30, 60, 90, and 120 mg/kg per day for 15 days. Both drugs caused proteinuria and a decrease in urine osmolality; however, netilmicin produced significantly less changes at all doses than gentamicin. Whereas gentamicin resulted in a decline in creatinine clearance at all doses, netilmicin failed to cause a decline in creatinine clearance. Renal-cortical concentrations of antibiotic at sacrifice were similar in animals receiving either drug. Light-microscopic changes were less severe with netilmicin than gentamicin. Cytosegresomes with myeloid bodies were identified electron microscopically in the kidneys of animals receiving either netilmicin or gentamicin at all doses. Electron-microscopic manifestations were similar. The data indicate that in the rat, netilmicin is distinctly less nephrotoxic than gentamicin.  (+info)

Total parenteral nutrition in the management of acute renal failure. (4/1427)

Malnutrition is frequently present in patients with acute renal failure and may affect morbidity and mortality in this condition. When adequate nourishment cannot be given through the gastrointestinal tract, total parental nutrition with amino acids and hypertonic glucose may have beneficial results. Total parenteral nutrition has been reported to stabilize or reduce serum urea nitrogen, potassium and phosphorus levels, improve wound healing, enhance survival from acute renal failure, and possibly increase the rate of recovery of renal function. The optimal composition of the total parenteral nutrition infusate is unknown. Preliminary results of a double-blind study are reported in which one man received hypertonic glucose alone, two received glucose with essential amino acids (21 g/day), and three received glucose with essential (21 g/day) and nonessential (21 g/day) amino acids. All infusates were isocaloric. No differences were observed in serum urea nitrogen levels, serum urea nitrogen/creatinine ratios or urea appearance rates. Nitrogen balance was negative in all patients. The ratio of essential amino acids/nonessential amino acids were higher and the tyrosine/phenylalanine ratios were lower in plasma in the two patients receiving glucose with essential amino acids. No patient survived the hospitalization. In view of the markedly negative nitrogen balance frequently observed in these and earlier studies, the use of a different composition or quantity of amino acids, a higher energy intake, and anabolic hormones deserve further investigation.  (+info)

Measurement of the delivery of dialysis in acute renal failure. (5/1427)

BACKGROUND: Recent studies in patients with acute renal failure (ARF) have shown a relationship between the delivered dose of dialysis and patient survival. However, there is currently no consensus on the appropriate method to measure the dose of dialysis in ARF patients. In this study, the dose of dialysis was measured by blood- and dialysate-based kinetic methods in a group of ARF patients who required intermittent hemodialysis. METHODS: Treatments were performed using a Fresenius 2008E volumetric hemodialysis machine with the ability to fractionally collect the spent dialysate. Single-, double-pool, and equilibrated Kt/V were determined from the pre-, immediate post-, and 30-minute post-blood urea nitrogen (BUN) measurements. The solute reduction index was determined from the collected dialysate, as well as the single- and double-pool Kt/V. RESULTS: Forty-six treatments in 28 consecutive patients were analyzed. The mean prescribed Kt/V (1.11 +/- 0.32) was significantly greater than the delivered dose estimated by single-pool (0.96 +/- 0.33), equilibrated (0.84 +/- 0.28), and double-pool (0.84 +/- 0.30) Kt/V (compared with prescribed, each P < 0.001). There was no statistical difference between the equilibrated and double-pool Kt/V (P = NS). The solute removal index, as determined from the dialysate, corresponded to a Kt/V of 0.56 +/- 0.27 and was significantly lower than the single-pool and double-pool Kt/V (each P < 0.001). CONCLUSION: Blood-based kinetics used to estimate the dose of dialysis in ARF patients on intermittent hemodialysis provide internally consistent results. However, when compared with dialysate-side kinetics, blood-based kinetics substantially overestimated the amount of solute (urea) removal.  (+info)

Effects of carbon dioxide inhalation on hematology, coagulation, and serum clinical chemistry values in rats. (6/1427)

Blood samples from adult male and female Charles River Crl:CD (SD) BR rats were collected at weekly intervals for 4 wk to evaluate the effects of inhalation of an anesthetic dose of carbon dioxide (CO2) or of a carbon dioxide-oxygen mixture (CO2/O2) on hematology, coagulation, and serum biochemistry values. During the first 3 wk of the study, rats were assigned to 1 of 3 groups and were bled from the orbital sinus once weekly. Prior to the blood collection, rats in group 1 were exposed to room air only, rats in group 2 received CO2/O2 (approximately 66%:34% CO2:O2) by inhalation, and rats in group 3 received 100% CO2 by inhalation. In the rats exposed to CO2/O2 or CO2, leukocyte counts, lymphocyte counts, and glucose values were higher, and aspartate aminotransferase, creatine kinase, and calcium values were lower compared with those of rats exposed to room air only. Rats exposed to 100% CO2 had slightly (but statistically significant) lower mean corpuscular hemoglobin concentration when compared with rats exposed only to room air. During week 4, all rats were reassigned to 1 of 2 groups and were bled terminally via closed cardiac puncture following exposure to either CO2/O2 or CO2. Increased lymphocyte counts (males only) and glucose and chloride concentrations were noted for rats exposed to CO2/O2 compared with those exposed to CO2. These alterations reiterate the importance of comparing clinical pathology values to those of concurrent control groups that have experienced blood collection under identical conditions in order to avoid potential errors in the interpretation of data.  (+info)

Nordihydroguairetic acid is a potent inhibitor of ferric-nitrilotriacetate-mediated hepatic and renal toxicity, and renal tumour promotion, in mice. (7/1427)

Ferric-nitrilotriacetate (Fe-NTA) is a known renal carcinogen. In the present study, we report the effect of a potent lignin-derived herbal antioxidant, nordihydroguairetic acid (NDGA), against Fe-NTA-mediated tissue toxicity. Fe-NTA (alone) treatment of mice enhances ornithine decarboxylase activity to 259% in liver and 341% in kidney and increases [3H]thymidine incorporation in DNA to 250% in liver and 324% in kidney compared with the corresponding saline-treated controls. The enhanced ornithine decarboxylase activity and DNA synthesis showed a reduction to 138 and 123%, respectively, in liver at a higher dose of 2 mg NDGA/day/animal whereas in kidney the reduction was to 118 and 102%, respectively, compared with the corresponding saline-treated controls. In the Fe-NTA (alone)-treated group, a 12% renal tumour incidence was recorded whereas, in N-diethylnitrosamine (DEN)-initiated and Fe-NTA-promoted animals, the percentage tumour incidence was increased to 68% as compared with untreated controls. No tumour incidence was recorded in the DEN-initiated, non-promoted group. The administration of NDGA, afforded >80% protection against DEN- and Fe-NTA-mediated renal tissue injury in vivo. Fe-NTA treatment also enhanced hepatic and renal microsomal lipid peroxidation to 170 and 205% of saline-treated controls, respectively, and hydrogen peroxide generation by >2.5-fold in both tissues accompanied by a 51 and 21% decrease in the level of glutathione and 35-48 and 35-50% decrease in the activities of glutathione-metabolizing and antioxidant enzymes in liver and kidney, respectively. These changes were reversed significantly in animals receiving a pre-treatment of NDGA. Our data show that NDGA can abrogate the toxic and tumour-promoting effects of Fe-NTA in liver and kidney of mice and can serve as a potent chemopreventive agent to suppress oxidant-induced tissue injury and tumorigenesis.  (+info)

Protein metabolism in insulin-treated gestational diabetes. (8/1427)

OBJECTIVE: To test the hypothesis that protein metabolism is not totally normalized in insulin treated gestational diabetes mellitus (GDM) patients compared with normal, pregnant control subjects. RESEARCH DESIGN AND METHODS: Protein metabolism in eight Hispanic women with insulin-treated GDM and eight healthy Hispanic control women was studied in late gestation and at 6 weeks postpartum. Nitrogen flux was assessed from the disposal rate of [15N]-labeled urea over 12 h after a dose of [15N]-labeled leucine. Plasma amino acid concentrations were determined in fasting and 2-h postprandial samples using an amino acid analyzer. RESULTS: Protein turnover was normalized in insulin-treated GDM; however, fasting and postprandial plasma amino acids were elevated antepartum and postpartum. Nitrogen flux was significantly lower during pregnancy (P = 0.04-0.001) and did not differ between groups. Fasting and postprandial plasma amino acids were elevated in GDM antepartum and postpartum, despite satisfactory glycemic control. Fasting levels of taurine, hydroxyproline, glutamic acid, glutamine, cystine, tyrosine, phenylalanine, tryptophan, and histidine were higher in GDM antepartum and postpartum (P < 0.05). Postprandial concentrations of taurine, hydroxyproline, valine, cystine, isoleucine, leucine, tyrosine, phenylalanine, tryptophan, ornithine, lysine, histidine, and arginine were higher in GDM antepartum and postpartum (P < 0.05). With few exceptions, plasma amino acid concentrations were lower antepartum than postpartum (P < 0.05). CONCLUSIONS: Protein turnover was normalized in insulin-treated women with GDM; however, fasting and postprandial plasma concentrations of amino acids were elevated in the antepartum and postpartum periods, despite satisfactory maternal glycemic control.  (+info)

The definition of AKI has evolved over time, and it is now defined as a syndrome characterized by an abrupt or rapid decrease in kidney function, with or without oliguria (decreased urine production), and with evidence of tubular injury. The RIFLE (Risk, Injury, Failure, Loss, and End-stage kidney disease) criteria are commonly used to diagnose and stage AKI based on serum creatinine levels, urine output, and other markers of kidney damage.

There are three stages of AKI, with stage 1 representing mild injury and stage 3 representing severe and potentially life-threatening injury. Treatment of AKI typically involves addressing the underlying cause, correcting fluid and electrolyte imbalances, and providing supportive care to maintain blood pressure and oxygenation. In some cases, dialysis may be necessary to remove waste products from the blood.

Early detection and treatment of AKI are crucial to prevent long-term damage to the kidneys and improve outcomes for patients.

Types of Kidney Diseases:

1. Acute Kidney Injury (AKI): A sudden and reversible loss of kidney function that can be caused by a variety of factors, such as injury, infection, or medication.
2. Chronic Kidney Disease (CKD): A gradual and irreversible loss of kidney function that can lead to end-stage renal disease (ESRD).
3. End-Stage Renal Disease (ESRD): A severe and irreversible form of CKD that requires dialysis or a kidney transplant.
4. Glomerulonephritis: An inflammation of the glomeruli, the tiny blood vessels in the kidneys that filter waste products.
5. Interstitial Nephritis: An inflammation of the tissue between the tubules and blood vessels in the kidneys.
6. Kidney Stone Disease: A condition where small, hard mineral deposits form in the kidneys and can cause pain, bleeding, and other complications.
7. Pyelonephritis: An infection of the kidneys that can cause inflammation, damage to the tissues, and scarring.
8. Renal Cell Carcinoma: A type of cancer that originates in the cells of the kidney.
9. Hemolytic Uremic Syndrome (HUS): A condition where the immune system attacks the platelets and red blood cells, leading to anemia, low platelet count, and damage to the kidneys.

Symptoms of Kidney Diseases:

1. Blood in urine or hematuria
2. Proteinuria (excess protein in urine)
3. Reduced kidney function or renal insufficiency
4. Swelling in the legs, ankles, and feet (edema)
5. Fatigue and weakness
6. Nausea and vomiting
7. Abdominal pain
8. Frequent urination or polyuria
9. Increased thirst and drinking (polydipsia)
10. Weight loss

Diagnosis of Kidney Diseases:

1. Physical examination
2. Medical history
3. Urinalysis (test of urine)
4. Blood tests (e.g., creatinine, urea, electrolytes)
5. Imaging studies (e.g., X-rays, CT scans, ultrasound)
6. Kidney biopsy
7. Other specialized tests (e.g., 24-hour urinary protein collection, kidney function tests)

Treatment of Kidney Diseases:

1. Medications (e.g., diuretics, blood pressure medication, antibiotics)
2. Diet and lifestyle changes (e.g., low salt intake, increased water intake, physical activity)
3. Dialysis (filtering waste products from the blood when the kidneys are not functioning properly)
4. Kidney transplantation ( replacing a diseased kidney with a healthy one)
5. Other specialized treatments (e.g., plasmapheresis, hemodialysis)

Prevention of Kidney Diseases:

1. Maintaining a healthy diet and lifestyle
2. Monitoring blood pressure and blood sugar levels
3. Avoiding harmful substances (e.g., tobacco, excessive alcohol consumption)
4. Managing underlying medical conditions (e.g., diabetes, high blood pressure)
5. Getting regular check-ups and screenings

Early detection and treatment of kidney diseases can help prevent or slow the progression of the disease, reducing the risk of complications and improving quality of life. It is important to be aware of the signs and symptoms of kidney diseases and seek medical attention if they are present.

In this answer, we will explore the definition of 'Kidney Tubular Necrosis, Acute' in more detail, including its causes, symptoms, diagnosis, and treatment options.

What is Kidney Tubular Necrosis, Acute?
------------------------------------------

Kidney Tubular Necrosis, Acute (ATN) is a condition that affects the tubules of the kidneys, leading to inflammation and damage. The condition is often caused by various factors such as sepsis, shock, toxins, or medications.

The term "acute" refers to the sudden and severe nature of the condition, which can progress rapidly within hours or days. The condition can be life-threatening if left untreated, and it is important to seek medical attention immediately if symptoms persist or worsen over time.

Causes of Kidney Tubular Necrosis, Acute
--------------------------------------

There are various factors that can cause Kidney Tubular Necrosis, Acute, including:

### 1. Sepsis

Sepsis is a systemic inflammatory response to an infection, which can lead to damage to the tubules of the kidneys.

### 2. Shock

Shock can cause a decrease in blood flow to the kidneys, leading to damage and inflammation.

### 3. Toxins

Exposure to certain toxins, such as heavy metals or certain medications, can damage the tubules of the kidneys.

### 4. Medications

Certain medications, such as antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs), can cause damage to the tubules of the kidneys.

### 5. Infection

Infections such as pyelonephritis or perinephric abscess can spread to the kidneys and cause inflammation and damage to the tubules.

### 6. Radiation necrosis

Radiation therapy can cause damage to the kidneys, leading to inflammation and scarring.

### 7. Kidney transplant rejection

Rejection of a kidney transplant can lead to inflammation and damage to the tubules of the transplanted kidney.

Symptoms of Kidney Tubular Necrosis, Acute
------------------------------------------

The symptoms of acute tubular necrosis can vary depending on the severity of the condition and the underlying cause. Some common symptoms include:

### 1. Fatigue

Fatigue is a common symptom of acute tubular necrosis, as the condition can lead to a decrease in the kidneys' ability to filter waste products from the blood.

### 2. Nausea and vomiting

Nausea and vomiting can occur due to electrolyte imbalances and changes in fluid levels in the body.

### 3. Decreased urine output

Acute tubular necrosis can cause a decrease in urine production, as the damaged tubules are unable to filter waste products from the blood effectively.

### 4. Swelling (edema)

Swelling in the legs, ankles, and feet can occur due to fluid buildup in the body.

### 5. Abdominal pain

Abdominal pain can be a symptom of acute tubular necrosis, as the condition can cause inflammation and scarring in the kidneys.

### 6. Fever

Fever can occur due to infection or inflammation in the kidneys.

### 7. Blood in urine (hematuria)

Hematuria, or blood in the urine, can be a symptom of acute tubular necrosis, as the damaged tubules can leak blood into the urine.

## Causes and risk factors

The exact cause of acute tubular necrosis is not fully understood, but it is believed to be due to damage to the kidney tubules, which can occur for a variety of reasons. Some possible causes and risk factors include:

1. Sepsis: Bacterial infections can spread to the kidneys and cause inflammation and damage to the tubules.
2. Toxins: Exposure to certain toxins, such as heavy metals or certain medications, can damage the kidney tubules.
3. Medications: Certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and antibiotics, can cause kidney damage and increase the risk of acute tubular necrosis.
4. Hypotension: Low blood pressure can reduce blood flow to the kidneys and increase the risk of acute tubular necrosis.
5. Shock: Severe shock can lead to damage to the kidney tubules.
6. Burns: Severe burns can cause damage to the kidneys and increase the risk of acute tubular necrosis.
7. Trauma: Traumatic injuries, such as those caused by car accidents or falls, can damage the kidneys and increase the risk of acute tubular necrosis.
8. Surgery: Major surgery can cause damage to the kidneys and increase the risk of acute tubular necrosis.
9. Kidney disease: People with pre-existing kidney disease are at increased risk of developing acute tubular necrosis.
10. Chronic conditions: Certain chronic conditions, such as diabetes and high blood pressure, can increase the risk of developing acute tubular necrosis.

It is important to note that acute tubular necrosis can occur in people with no underlying medical conditions or risk factors, and it is often a diagnosis of exclusion, meaning that other potential causes of the person's symptoms must be ruled out before the diagnosis can be made.

Reperfusion injury can cause inflammation, cell death, and impaired function in the affected tissue or organ. The severity of reperfusion injury can vary depending on the duration and severity of the initial ischemic event, as well as the promptness and effectiveness of treatment to restore blood flow.

Reperfusion injury can be a complicating factor in various medical conditions, including:

1. Myocardial infarction (heart attack): Reperfusion injury can occur when blood flow is restored to the heart muscle after a heart attack, leading to inflammation and cell death.
2. Stroke: Reperfusion injury can occur when blood flow is restored to the brain after an ischemic stroke, leading to inflammation and damage to brain tissue.
3. Organ transplantation: Reperfusion injury can occur when a transplanted organ is subjected to ischemia during harvesting or preservation, and then reperfused with blood.
4. Peripheral arterial disease: Reperfusion injury can occur when blood flow is restored to a previously occluded peripheral artery, leading to inflammation and damage to the affected tissue.

Treatment of reperfusion injury often involves medications to reduce inflammation and oxidative stress, as well as supportive care to manage symptoms and prevent further complications. In some cases, experimental therapies such as stem cell transplantation or gene therapy may be used to promote tissue repair and regeneration.

Treatment for uremia typically involves dialysis or kidney transplantation to remove excess urea from the blood and restore normal kidney function. In some cases, medications may be prescribed to help manage symptoms such as high blood pressure, anemia, or electrolyte imbalances.

The term "uremia" is derived from the Greek words "oura," meaning "urea," and "emia," meaning "in the blood." It was first used in the medical literature in the late 19th century to describe a condition caused by excess urea in the blood. Today, it remains an important diagnostic term in nephrology and is often used interchangeably with the term "uremic syndrome."

A condition in which the kidneys gradually lose their function over time, leading to the accumulation of waste products in the body. Also known as chronic kidney disease (CKD).

Prevalence:

Chronic kidney failure affects approximately 20 million people worldwide and is a major public health concern. In the United States, it is estimated that 1 in 5 adults has CKD, with African Americans being disproportionately affected.

Causes:

The causes of chronic kidney failure are numerous and include:

1. Diabetes: High blood sugar levels can damage the kidneys over time.
2. Hypertension: Uncontrolled high blood pressure can cause damage to the blood vessels in the kidneys.
3. Glomerulonephritis: An inflammation of the glomeruli, the tiny blood vessels in the kidneys that filter waste and excess fluids from the blood.
4. Interstitial nephritis: Inflammation of the tissue between the kidney tubules.
5. Pyelonephritis: Infection of the kidneys, usually caused by bacteria or viruses.
6. Polycystic kidney disease: A genetic disorder that causes cysts to grow on the kidneys.
7. Obesity: Excess weight can increase blood pressure and strain on the kidneys.
8. Family history: A family history of kidney disease increases the risk of developing chronic kidney failure.

Symptoms:

Early stages of chronic kidney failure may not cause any symptoms, but as the disease progresses, symptoms can include:

1. Fatigue: Feeling tired or weak.
2. Swelling: In the legs, ankles, and feet.
3. Nausea and vomiting: Due to the buildup of waste products in the body.
4. Poor appetite: Loss of interest in food.
5. Difficulty concentrating: Cognitive impairment due to the buildup of waste products in the brain.
6. Shortness of breath: Due to fluid buildup in the lungs.
7. Pain: In the back, flank, or abdomen.
8. Urination changes: Decreased urine production, dark-colored urine, or blood in the urine.
9. Heart problems: Chronic kidney failure can increase the risk of heart disease and heart attack.

Diagnosis:

Chronic kidney failure is typically diagnosed based on a combination of physical examination findings, medical history, laboratory tests, and imaging studies. Laboratory tests may include:

1. Blood urea nitrogen (BUN) and creatinine: Waste products in the blood that increase with decreased kidney function.
2. Electrolyte levels: Imbalances in electrolytes such as sodium, potassium, and phosphorus can indicate kidney dysfunction.
3. Kidney function tests: Measurement of glomerular filtration rate (GFR) to determine the level of kidney function.
4. Urinalysis: Examination of urine for protein, blood, or white blood cells.

Imaging studies may include:

1. Ultrasound: To assess the size and shape of the kidneys, detect any blockages, and identify any other abnormalities.
2. Computed tomography (CT) scan: To provide detailed images of the kidneys and detect any obstructions or abscesses.
3. Magnetic resonance imaging (MRI): To evaluate the kidneys and detect any damage or scarring.

Treatment:

Treatment for chronic kidney failure depends on the underlying cause and the severity of the disease. The goals of treatment are to slow progression of the disease, manage symptoms, and improve quality of life. Treatment may include:

1. Medications: To control high blood pressure, lower cholesterol levels, reduce proteinuria, and manage anemia.
2. Diet: A healthy diet that limits protein intake, controls salt and water intake, and emphasizes low-fat dairy products, fruits, and vegetables.
3. Fluid management: Monitoring and control of fluid intake to prevent fluid buildup in the body.
4. Dialysis: A machine that filters waste products from the blood when the kidneys are no longer able to do so.
5. Transplantation: A kidney transplant may be considered for some patients with advanced chronic kidney failure.

Complications:

Chronic kidney failure can lead to several complications, including:

1. Heart disease: High blood pressure and anemia can increase the risk of heart disease.
2. Anemia: A decrease in red blood cells can cause fatigue, weakness, and shortness of breath.
3. Bone disease: A disorder that can lead to bone pain, weakness, and an increased risk of fractures.
4. Electrolyte imbalance: Imbalances of electrolytes such as potassium, phosphorus, and sodium can cause muscle weakness, heart arrhythmias, and other complications.
5. Infections: A decrease in immune function can increase the risk of infections.
6. Nutritional deficiencies: Poor appetite, nausea, and vomiting can lead to malnutrition and nutrient deficiencies.
7. Cardiovascular disease: High blood pressure, anemia, and other complications can increase the risk of cardiovascular disease.
8. Pain: Chronic kidney failure can cause pain, particularly in the back, flank, and abdomen.
9. Sleep disorders: Insomnia, sleep apnea, and restless leg syndrome are common complications.
10. Depression and anxiety: The emotional burden of chronic kidney failure can lead to depression and anxiety.

Proteinuria is usually diagnosed by a urine protein-to-creatinine ratio (P/C ratio) or a 24-hour urine protein collection. The amount and duration of proteinuria can help distinguish between different underlying causes and predict prognosis.

Proteinuria can have significant clinical implications, as it is associated with increased risk of cardiovascular disease, kidney damage, and malnutrition. Treatment of the underlying cause can help reduce or eliminate proteinuria.

Body weight is an important health indicator, as it can affect an individual's risk for certain medical conditions, such as obesity, diabetes, and cardiovascular disease. Maintaining a healthy body weight is essential for overall health and well-being, and there are many ways to do so, including a balanced diet, regular exercise, and other lifestyle changes.

There are several ways to measure body weight, including:

1. Scale: This is the most common method of measuring body weight, and it involves standing on a scale that displays the individual's weight in kg or lb.
2. Body fat calipers: These are used to measure body fat percentage by pinching the skin at specific points on the body.
3. Skinfold measurements: This method involves measuring the thickness of the skin folds at specific points on the body to estimate body fat percentage.
4. Bioelectrical impedance analysis (BIA): This is a non-invasive method that uses electrical impulses to measure body fat percentage.
5. Dual-energy X-ray absorptiometry (DXA): This is a more accurate method of measuring body composition, including bone density and body fat percentage.

It's important to note that body weight can fluctuate throughout the day due to factors such as water retention, so it's best to measure body weight at the same time each day for the most accurate results. Additionally, it's important to use a reliable scale or measuring tool to ensure accurate measurements.

There are two main types of Renal Insufficiency:

1. Acute Kidney Injury (AKI): This is a sudden and reversible decrease in kidney function, often caused by injury, sepsis, or medication toxicity. AKI can resolve with appropriate treatment and supportive care.
2. Chronic Renal Insufficiency (CRI): This is a long-standing and irreversible decline in kidney function, often caused by diabetes, high blood pressure, or chronic kidney disease. CRI can lead to ESRD if left untreated.

Signs and symptoms of Renal Insufficiency may include:

* Decreased urine output
* Swelling in the legs and ankles (edema)
* Fatigue
* Nausea and vomiting
* Shortness of breath (dyspnea)
* Pain in the back, flank, or abdomen

Diagnosis of Renal Insufficiency is typically made through a combination of physical examination, medical history, laboratory tests, and imaging studies. Laboratory tests may include urinalysis, blood urea nitrogen (BUN) and creatinine levels, and a 24-hour urine protein collection. Imaging studies, such as ultrasound or CT scans, may be used to evaluate the kidneys and rule out other possible causes of the patient's symptoms.

Treatment of Renal Insufficiency depends on the underlying cause and the severity of the condition. Treatment may include medications to control blood pressure, manage fluid balance, and reduce proteinuria (excess protein in the urine). In some cases, dialysis or a kidney transplant may be necessary.

Prevention of Renal Insufficiency includes managing underlying conditions such as diabetes and hypertension, avoiding nephrotoxic medications and substances, and maintaining a healthy diet and lifestyle. Early detection and treatment of acute kidney injury can also help prevent the development of chronic renal insufficiency.

In conclusion, Renal Insufficiency is a common condition that can have significant consequences if left untreated. It is important for healthcare providers to be aware of the causes, symptoms, and diagnosis of Renal Insufficiency, as well as the treatment and prevention strategies available. With appropriate management, many patients with Renal Insufficiency can recover and maintain their kidney function over time.

Rhabdomyolysis can be caused by a variety of factors, including:

1. Physical trauma or injury to the muscles
2. Overuse or strain of muscles
3. Poor physical conditioning or training
4. Infections such as viral or bacterial infections that affect the muscles
5. Certain medications or drugs, such as statins and antibiotics
6. Alcohol or drug poisoning
7. Heat stroke or other forms of extreme heat exposure
8. Hypothyroidism (underactive thyroid)
9. Genetic disorders that affect muscle function.

Symptoms of rhabdomyolysis can include:

1. Muscle weakness or paralysis
2. Muscle pain or cramping
3. Confusion or disorientation
4. Dark urine or decreased urine output
5. Fever, nausea, and vomiting
6. Shortness of breath or difficulty breathing
7. Abnormal heart rhythms or cardiac arrest.

If you suspect that someone has rhabdomyolysis, it is important to seek medical attention immediately. Treatment typically involves supportive care, such as fluids and electrolyte replacement, as well as addressing any underlying causes of the condition. In severe cases, hospitalization may be necessary to monitor and treat complications such as kidney failure or cardiac problems.

1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.

2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.

3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.

4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.

5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.

6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.

7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.

8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.

9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.

10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.

Here are some possible causes of myoglobinuria:

1. Muscle injury or trauma: This can cause myoglobin to leak into the bloodstream and then into the urine.
2. Muscle disease: Certain muscle diseases, such as muscular dystrophy, can cause myoglobinuria.
3. Kidney damage: Myoglobin can accumulate in the kidneys and cause damage if the kidneys are not functioning properly.
4. Sepsis: Sepsis is a systemic infection that can cause muscle breakdown and myoglobinuria.
5. Burns: Severe burns can cause muscle damage and lead to myoglobinuria.
6. Heart attack: A heart attack can cause muscle damage and myoglobinuria.
7. Rhabdomyolysis: This is a condition where the muscles break down and release myoglobin into the bloodstream. It can be caused by various factors such as medication, infection, or injury.

Symptoms of myoglobinuria may include dark urine, proteinuria (excess protein in the urine), and kidney damage. Treatment depends on the underlying cause and may involve supportive care, medication, or dialysis to remove waste products from the blood.

The symptoms of glomerulonephritis can vary depending on the underlying cause of the disease, but may include:

* Blood in the urine (hematuria)
* Proteinuria (excess protein in the urine)
* Reduced kidney function
* Swelling in the legs and ankles (edema)
* High blood pressure

Glomerulonephritis can be caused by a variety of factors, including:

* Infections such as staphylococcal or streptococcal infections
* Autoimmune disorders such as lupus or rheumatoid arthritis
* Allergic reactions to certain medications
* Genetic defects
* Certain diseases such as diabetes, high blood pressure, and sickle cell anemia

The diagnosis of glomerulonephritis typically involves a physical examination, medical history, and laboratory tests such as urinalysis, blood tests, and kidney biopsy.

Treatment for glomerulonephritis depends on the underlying cause of the disease and may include:

* Antibiotics to treat infections
* Medications to reduce inflammation and swelling
* Diuretics to reduce fluid buildup in the body
* Immunosuppressive medications to suppress the immune system in cases of autoimmune disorders
* Dialysis in severe cases

The prognosis for glomerulonephritis depends on the underlying cause of the disease and the severity of the inflammation. In some cases, the disease may progress to end-stage renal disease, which requires dialysis or a kidney transplant. With proper treatment, however, many people with glomerulonephritis can experience a good outcome and maintain their kidney function over time.

Nephritis is often diagnosed through a combination of physical examination, medical history, and laboratory tests such as urinalysis and blood tests. Treatment for nephritis depends on the underlying cause, but may include antibiotics, corticosteroids, and immunosuppressive medications. In severe cases, dialysis may be necessary to remove waste products from the blood.

Some common types of nephritis include:

1. Acute pyelonephritis: This is a type of bacterial infection that affects the kidneys and can cause sudden and severe symptoms.
2. Chronic pyelonephritis: This is a type of inflammation that occurs over a longer period of time, often as a result of recurrent infections or other underlying conditions.
3. Lupus nephritis: This is a type of inflammation that occurs in people with systemic lupus erythematosus (SLE), an autoimmune disorder that can affect multiple organs.
4. IgA nephropathy: This is a type of inflammation that occurs when an antibody called immunoglobulin A (IgA) deposits in the kidneys and causes damage.
5. Mesangial proliferative glomerulonephritis: This is a type of inflammation that affects the mesangium, a layer of tissue in the kidney that helps to filter waste products from the blood.
6. Minimal change disease: This is a type of nephrotic syndrome (a group of symptoms that include proteinuria, or excess protein in the urine) that is caused by inflammation and changes in the glomeruli, the tiny blood vessels in the kidneys that filter waste products from the blood.
7. Membranous nephropathy: This is a type of inflammation that occurs when there is an abnormal buildup of antibodies called immunoglobulin G (IgG) in the glomeruli, leading to damage to the kidneys.
8. Focal segmental glomerulosclerosis: This is a type of inflammation that affects one or more segments of the glomeruli, leading to scarring and loss of function.
9. Post-infectious glomerulonephritis: This is a type of inflammation that occurs after an infection, such as streptococcal infections, and can cause damage to the kidneys.
10. Acute tubular necrosis (ATN): This is a type of inflammation that occurs when there is a sudden loss of blood flow to the kidneys, causing damage to the tubules, which are tiny tubes in the kidneys that help to filter waste products from the blood.

There are several different types of weight gain, including:

1. Clinical obesity: This is defined as a BMI of 30 or higher, and is typically associated with a range of serious health problems, such as heart disease, type 2 diabetes, and certain types of cancer.
2. Central obesity: This refers to excess fat around the waistline, which can increase the risk of health problems such as heart disease and type 2 diabetes.
3. Muscle gain: This occurs when an individual gains weight due to an increase in muscle mass, rather than fat. This type of weight gain is generally considered healthy and can improve overall fitness and athletic performance.
4. Fat gain: This occurs when an individual gains weight due to an increase in body fat, rather than muscle or bone density. Fat gain can increase the risk of health problems such as heart disease and type 2 diabetes.

Weight gain can be measured using a variety of methods, including:

1. Body mass index (BMI): This is a widely used measure of weight gain that compares an individual's weight to their height. A BMI of 18.5-24.9 is considered normal, while a BMI of 25-29.9 is considered overweight, and a BMI of 30 or higher is considered obese.
2. Waist circumference: This measures the distance around an individual's waistline and can be used to assess central obesity.
3. Skinfold measurements: These involve measuring the thickness of fat at specific points on the body, such as the abdomen or thighs.
4. Dual-energy X-ray absorptiometry (DXA): This is a non-invasive test that uses X-rays to measure bone density and body composition.
5. Bioelectrical impedance analysis (BIA): This is a non-invasive test that uses electrical impulses to measure body fat percentage and other physiological parameters.

Causes of weight gain:

1. Poor diet: Consuming high amounts of processed foods, sugar, and saturated fats can lead to weight gain.
2. Lack of physical activity: Engaging in regular exercise can help burn calories and maintain a healthy weight.
3. Genetics: An individual's genetic makeup can affect their metabolism and body composition, making them more prone to weight gain.
4. Hormonal imbalances: Imbalances in hormones such as insulin, thyroid, and cortisol can contribute to weight gain.
5. Medications: Certain medications, such as steroids and antidepressants, can cause weight gain as a side effect.
6. Sleep deprivation: Lack of sleep can disrupt hormones that regulate appetite and metabolism, leading to weight gain.
7. Stress: Chronic stress can lead to emotional eating and weight gain.
8. Age: Metabolism slows down with age, making it more difficult to maintain a healthy weight.
9. Medical conditions: Certain medical conditions such as hypothyroidism, Cushing's syndrome, and polycystic ovary syndrome (PCOS) can also contribute to weight gain.

Treatment options for obesity:

1. Lifestyle modifications: A combination of diet, exercise, and stress management techniques can help individuals achieve and maintain a healthy weight.
2. Medications: Prescription medications such as orlistat, phentermine-topiramate, and liraglutide can aid in weight loss.
3. Bariatric surgery: Surgical procedures such as gastric bypass surgery and sleeve gastrectomy can be effective for severe obesity.
4. Behavioral therapy: Cognitive-behavioral therapy (CBT) and other forms of counseling can help individuals develop healthy eating habits and improve their physical activity levels.
5. Meal replacement plans: Meal replacement plans such as Medifast can provide individuals with a structured diet that is high in protein, fiber, and vitamins, and low in calories and sugar.
6. Weight loss supplements: Supplements such as green tea extract, garcinia cambogia, and forskolin can help boost weight loss efforts.
7. Portion control: Using smaller plates and measuring cups can help individuals regulate their portion sizes and maintain a healthy weight.
8. Mindful eating: Paying attention to hunger and fullness cues, eating slowly, and savoring food can help individuals develop healthy eating habits.
9. Physical activity: Engaging in regular physical activity such as walking, running, swimming, or cycling can help individuals burn calories and maintain a healthy weight.

It's important to note that there is no one-size-fits-all approach to treating obesity, and the most effective treatment plan will depend on the individual's specific needs and circumstances. Consulting with a healthcare professional such as a registered dietitian or a physician can help individuals develop a personalized treatment plan that is safe and effective.

There are several types of ischemia, including:

1. Myocardial ischemia: Reduced blood flow to the heart muscle, which can lead to chest pain or a heart attack.
2. Cerebral ischemia: Reduced blood flow to the brain, which can lead to stroke or cognitive impairment.
3. Peripheral arterial ischemia: Reduced blood flow to the legs and arms.
4. Renal ischemia: Reduced blood flow to the kidneys.
5. Hepatic ischemia: Reduced blood flow to the liver.

Ischemia can be diagnosed through a variety of tests, including electrocardiograms (ECGs), stress tests, and imaging studies such as CT or MRI scans. Treatment for ischemia depends on the underlying cause and may include medications, lifestyle changes, or surgical interventions.

Some common examples of critical illnesses include:

1. Sepsis: a systemic inflammatory response to an infection that can lead to organ failure and death.
2. Cardiogenic shock: a condition where the heart is unable to pump enough blood to meet the body's needs, leading to serious complications such as heart failure and death.
3. Acute respiratory distress syndrome (ARDS): a condition where the lungs are severely inflamed and unable to provide sufficient oxygen to the body.
4. Multi-system organ failure: a condition where multiple organs in the body fail simultaneously, leading to serious complications and death.
5. Trauma: severe physical injuries sustained in an accident or other traumatic event.
6. Stroke: a sudden interruption of blood flow to the brain that can lead to permanent brain damage and death.
7. Myocardial infarction (heart attack): a blockage of coronary arteries that supply blood to the heart, leading to damage or death of heart muscle cells.
8. Pulmonary embolism: a blockage of the pulmonary artery, which can lead to respiratory failure and death.
9. Pancreatitis: inflammation of the pancreas that can lead to severe abdominal pain, bleeding, and organ failure.
10. Hypovolemic shock: a condition where there is a severe loss of blood or fluid from the body, leading to hypotension, organ failure, and death.

The diagnosis and treatment of critical illnesses require specialized knowledge and skills, and are typically handled by intensive care unit (ICU) teams consisting of critical care physicians, nurses, and other healthcare professionals. The goal of critical care is to provide life-sustaining interventions and support to patients who are critically ill until they recover or until their condition stabilizes.

Examples of acute diseases include:

1. Common cold and flu
2. Pneumonia and bronchitis
3. Appendicitis and other abdominal emergencies
4. Heart attacks and strokes
5. Asthma attacks and allergic reactions
6. Skin infections and cellulitis
7. Urinary tract infections
8. Sinusitis and meningitis
9. Gastroenteritis and food poisoning
10. Sprains, strains, and fractures.

Acute diseases can be treated effectively with antibiotics, medications, or other therapies. However, if left untreated, they can lead to chronic conditions or complications that may require long-term care. Therefore, it is important to seek medical attention promptly if symptoms persist or worsen over time.

There are several types of diabetic nephropathy, including:

1. Mesangial proliferative glomerulonephritis: This is the most common type of diabetic nephropathy and is characterized by an overgrowth of cells in the mesangium, a part of the glomerulus (the blood-filtering unit of the kidney).
2. Segmental sclerosis: This type of diabetic nephropathy involves the hardening of some parts of the glomeruli, leading to decreased kidney function.
3. Fibrotic glomerulopathy: This is a rare form of diabetic nephropathy that is characterized by the accumulation of fibrotic tissue in the glomeruli.
4. Membranous nephropathy: This type of diabetic nephropathy involves the deposition of immune complexes (antigen-antibody complexes) in the glomeruli, leading to inflammation and damage to the kidneys.
5. Minimal change disease: This is a rare form of diabetic nephropathy that is characterized by minimal changes in the glomeruli, but with significant loss of kidney function.

The symptoms of diabetic nephropathy can be non-specific and may include proteinuria (excess protein in the urine), hematuria (blood in the urine), and decreased kidney function. Diagnosis is typically made through a combination of physical examination, medical history, laboratory tests, and imaging studies such as ultrasound or CT scans.

Treatment for diabetic nephropathy typically involves managing blood sugar levels through lifestyle changes (such as diet and exercise) and medication, as well as controlling high blood pressure and other underlying conditions. In severe cases, dialysis or kidney transplantation may be necessary. Early detection and management of diabetic nephropathy can help slow the progression of the disease and improve outcomes for patients with this condition.

Necrosis is a type of cell death that occurs when cells are exposed to excessive stress, injury, or inflammation, leading to damage to the cell membrane and the release of cellular contents into the surrounding tissue. This can lead to the formation of gangrene, which is the death of body tissue due to lack of blood supply.

There are several types of necrosis, including:

1. Coagulative necrosis: This type of necrosis occurs when there is a lack of blood supply to the tissues, leading to the formation of a firm, white plaque on the surface of the affected area.
2. Liquefactive necrosis: This type of necrosis occurs when there is an infection or inflammation that causes the death of cells and the formation of pus.
3. Caseous necrosis: This type of necrosis occurs when there is a chronic infection, such as tuberculosis, and the affected tissue becomes soft and cheese-like.
4. Fat necrosis: This type of necrosis occurs when there is trauma to fatty tissue, leading to the formation of firm, yellowish nodules.
5. Necrotizing fasciitis: This is a severe and life-threatening form of necrosis that affects the skin and underlying tissues, often as a result of bacterial infection.

The diagnosis of necrosis is typically made through a combination of physical examination, imaging studies such as X-rays or CT scans, and laboratory tests such as biopsy. Treatment depends on the underlying cause of the necrosis and may include antibiotics, surgical debridement, or amputation in severe cases.

There are two main types of heart failure:

1. Left-sided heart failure: This occurs when the left ventricle, which is the main pumping chamber of the heart, becomes weakened and is unable to pump blood effectively. This can lead to congestion in the lungs and other organs.
2. Right-sided heart failure: This occurs when the right ventricle, which pumps blood to the lungs, becomes weakened and is unable to pump blood effectively. This can lead to congestion in the body's tissues and organs.

Symptoms of heart failure may include:

* Shortness of breath
* Fatigue
* Swelling in the legs, ankles, and feet
* Swelling in the abdomen
* Weight gain
* Coughing up pink, frothy fluid
* Rapid or irregular heartbeat
* Dizziness or lightheadedness

Treatment for heart failure typically involves a combination of medications and lifestyle changes. Medications may include diuretics to remove excess fluid from the body, ACE inhibitors or beta blockers to reduce blood pressure and improve blood flow, and aldosterone antagonists to reduce the amount of fluid in the body. Lifestyle changes may include a healthy diet, regular exercise, and stress reduction techniques. In severe cases, heart failure may require hospitalization or implantation of a device such as an implantable cardioverter-defibrillator (ICD) or a left ventricular assist device (LVAD).

It is important to note that heart failure is a chronic condition, and it requires ongoing management and monitoring to prevent complications and improve quality of life. With proper treatment and lifestyle changes, many people with heart failure are able to manage their symptoms and lead active lives.

There are several types of lupus nephritis, each with its own unique characteristics and symptoms. The most common forms include:

* Class I (mesangial proliferative glomerulonephritis): This type is characterized by the growth of abnormal cells in the glomeruli (blood-filtering units of the kidneys).
* Class II (active lupus nephritis): This type is characterized by widespread inflammation and damage to the kidneys, with or without the presence of antibodies.
* Class III (focal lupus nephritis): This type is characterized by localized inflammation in certain areas of the kidneys.
* Class IV (lupus nephritis with crescentic glomerulonephritis): This type is characterized by widespread inflammation and damage to the kidneys, with crescent-shaped tissue growth in the glomeruli.
* Class V (lupus nephritis with sclerotic changes): This type is characterized by hardening and shrinkage of the glomeruli due to scarring.

Lupus Nephritis can cause a range of symptoms, including:

* Proteinuria (excess protein in the urine)
* Hematuria (blood in the urine)
* Reduced kidney function
* Swelling (edema)
* Fatigue
* Fever
* Joint pain

Lupus Nephritis can be diagnosed through a combination of physical examination, medical history, laboratory tests, and kidney biopsy. Treatment options for lupus nephritis include medications to suppress the immune system, control inflammation, and prevent further damage to the kidneys. In severe cases, dialysis or a kidney transplant may be necessary.

... (BUN) is a medical test that measures the amount of urea nitrogen found in blood. The liver produces urea ... Each molecule of urea has two nitrogen atoms, each of molar mass 14g/mol. To convert from mg/dL of blood urea nitrogen to mmol/ ... Where 60 represents MW of urea and 14*2 MW of urea nitrogen. Kt/V Standardized Kt/V Urea reduction ratio Urine urea nitrogen ... Note that molar concentrations of urea and urea nitrogen are equal, because both nitrogen gas and urea has two nitrogen atoms. ...
Blood urea nitrogen Gerber GS, Brendler CB. Evaluation of the urologic patient: history, physical examination, and urinalysis. ... Urine urea nitrogen (UUN) refers to a test that measures the urine urea to assess nitrogen balance. Urea nitrogen is the end ... Nitrogen Balance = Protein intake/6.25- (UN + 4*) * For average loss via sweat and feces. Nitrogen balance value of 0 indicates ... By testing for UUN, clinicians can assess one's nitrogen balance. Calculating nitrogen balance is a useful tool in assessing ...
... blood, urea, nitrogen (BUN); and creatinine. Blood tests, complete blood count (CBC) and electrolytes. Imaging studies of the ... development of blood clots (thrombosis), blocking of arteries (embolism), and injury to adjacent structures, such as bowel or ... and disease progression in a case of inflammation of blood vessels, or vasculitis (one patient). One patient died of sepsis ( ...
Blood urea nitrogen (BUN) test measures the amount of urea nitrogen in the blood. Increased levels of urea in the blood (uremia ... blood urea nitrogen). A creatinine blood test and BUN test are usually performed together along with other blood panels for ... Baum N, Dichoso CC, Carlton CE (May 1975). "Blood urea nitrogen and serum creatinine. Physiology and interpretations". Urology ... urea is used by the body as a source of nitrogen essential for growth and life. The most relevant disorders on the urea cycle ...
90 mmHg Elevated serum blood urea nitrogen (> 40 mg/dL) or serum creatinine (> 1.5 mg/dL) Hepatitis B infection Arteriographic ... Individuals who are coughing up blood and have kidney involvement are likely to have granulomatosis with polyangiitis, ... Basic lab tests may include a complete blood count, chemiestries (look for creatinine), creatine phosphokinase level, liver ... on complete blood count Mononeuropathy or polyneuropathy Migratory or transient pulmonary opacities on chest x-ray Paranasal ...
Torre, Gregory M.; Lynch, Vincent D.; Jarowski, Charles I. (1981-01-01). "Lowering blood urea nitrogen with amino acid ...
60 mmHg or 7.9 kPa White blood cells > 15,000/µlitre Calcium < 2 mmol/litre Blood urea nitrogen > 16 mmol/litre Lactate ... blood urea nitrogen level >25 mg/dl (8.9 mmol/L), impaired mental status, systemic inflammatory response syndrome, age over 60 ... low blood calcium, high blood glucose, and dehydration. Blood loss, dehydration, and fluid leaking into the abdominal cavity ( ... Other causes include high levels of blood fats, high blood calcium, some medications, and certain genetic disorders, such as ...
Increases in serum levels of blood urea nitrogen and creatinine were detected. Long-term oral intake of Chinese herbal liquid ... High levels of blood sugar increased their expression and activity, which lead to an increase in hepatic glucose production and ... The same pathway was observed in peripheral blood lymphocytes. Geniposide has been reported as having a hypoglycemic effect, ... blood glucose, insulin and triglycerides (TG) levels. An increase in the activity of GP and G6Pas was also observed in this ...
Blood-sampling device Blood sugar A (misnomer) name for blood glucose. Blood urea nitrogen (BUN) A measurement of a metabolic ... Self-monitoring of blood glucose A way as person can test how much glucose (sugar) is in the blood. Also called home blood ... High blood pressure The pressure of blood in the arteries has normal values in a population. Blood pressure in an individual ... Postprandial blood glucose Blood taken 1-2 hours after eating to see the amount of glucose (sugar) in the blood. Prediabetes A ...
Blood Urea Nitrogen >28 mg/dL Glucose >252 mg/dL (14 mmol/L) Bicarbonate ...
For historical reasons, the lab test measuring urea is known as "blood urea nitrogen" (BUN). The BUN:Cr ratio is a useful ... This results in lower levels of urea in the blood and higher levels of urea in the urine as compared to creatinine. Creatinine ... such as urea, creatinine, various body waste compounds, and other nitrogen-rich compounds) in the blood. It is largely related ... Orthostatic blood pressure (fluctuates depending on body position) Uremic frost, a condition that occurs when urea and urea ...
A blood test may reveal increases in blood urea nitrogen (BUN), creatinine, phosphorus, and calcium. Emesis (induction of ... Dialysis of the blood (hemodialysis) and peritoneal dialysis can be used to support the kidneys if anuria develops. Oliguria ( ... increased blood calcium levels). "ASPCA Animal Poison Control Center Issues Nationwide Update: Raisins and Grapes Can Be Toxic ...
Azotemia is characterized as an increase of creatinine and blood urea nitrogen (BUN) in the plasma. Patients who have ... Blood vessels shrink and undergo apoptosis which results in poor blood flow in the kidneys. More complications happen when ... Because the blood vessels carry oxygen and nutrients throughout the body, having atherosclerosis restrict blood flow and ... By assessing the velocity of blood flow, the doctors can measure whether the kidney is receiving enough blood and nutrients to ...
Blood urea nitrogen can be used in estimating nitrogen balance, as the urea concentration in urine. Nitrogen is a fundamental ... Nitrogen balance is a measure of nitrogen input minus nitrogen output. Nitrogen Balance = Nitrogen intake - Nitrogen loss ... to ensure that all nitrogen exchange is accounted for. In order to control nitrogen inputs and losses, nitrogen balance studies ... A negative nitrogen balance can be used as part of a clinical evaluation of malnutrition. Nitrogen balance is the traditional ...
Females also had an increased blood urea nitrogen level while males had a decreased leukocyte cell number. GRCh38: Ensembl ...
consequently, urea cannot be produced and excess nitrogen accumulates in the blood in the form of ammonia. Ammonia and arginine ... The urea cycle is a sequence of reactions that occurs in liver cells (hepatocytes). This cycle processes excess nitrogen, ... which produces urea by extracting nitrogen from arginine. In people with arginase deficiency, arginase is missing, and arginine ... recessive urea cycle disorder where a deficiency of the enzyme arginase causes a buildup of arginine and ammonia in the blood. ...
A more elaborate version of the MDRD equation also includes serum albumin and blood urea nitrogen (BUN) levels: eGFR = 170 × [ ... The original MDRD used six variables with the additional variables being the blood urea nitrogen and albumin levels. The ... where the creatinine and blood urea nitrogen concentrations are both in mg/dL. The albumin concentration is in g/dL. These MDRD ... If the blood concentration is 0.01 mg/mL (1 mg/dL), then one can say that 100 mL/min of blood is being "cleared" of creatinine ...
This can be distinguished from hereditary orotic aciduria by assessing blood ammonia levels and blood urea nitrogen (BUN). In ... In orotic aciduria, the urea cycle is not affected. Orotic aciduria can be diagnosed through genetic sequencing of the UMPS ... Elevated urinary orotic acid levels can also arise secondary to blockage of the urea cycle, particularly in ornithine ... OTC deficiency, hyperammonemia and decreased BUN are seen because the urea cycle is not functioning properly, but megaloblastic ...
A basic metabolic panel measures sodium, potassium, chloride, bicarbonate, blood urea nitrogen (BUN), magnesium, creatinine, ... a protein or other biomolecule measured in a blood test Blood film, a way to look at blood cells under a microscope Blood lead ... Typical clinical blood panels include a basic metabolic panel or a complete blood count. Blood tests are also used in drug ... Determination of blood type for blood transfusion or transplants Blood cultures are commonly taken if infection is suspected. ...
... glucose testing and blood urea nitrogen (BUN) analysis.: 49-51 He is an innovator in the area of chemical-luminescence ... One instrument was designed to test blood samples for steroids and other drugs. Liston also developed specialty test ... instrumentation, particularly measurement of oxides of nitrogen.: 54 In addition, Liston and Lowell Edwards formed the Liston- ...
... pulmonary fibrosis and increase in blood urea nitrogen. These conclusions are based on the models that were used during these ...
Several lab test results, such as elevated blood urea nitrogen (BUN) and elevated creatinine, are illustrative of azotemia and ... Lab workup includes serum calcium levels, parathyroid hormone (PTH), phosphorus, creatinine, blood urea nitrogen (BUN), ... Currently, milk-alkali syndrome is the third most common cause of people hospitalized with high blood calcium, after ... Milk-alkali syndrome is characterized by elevated blood calcium levels, metabolic alkalosis, and acute kidney injury. Milk- ...
... blood urea nitrogen, electrolytes, and creatinine; determination of thyroid-stimulating hormone; and urinalysis. Other ... The following routine tests are recommended: Complete blood count Blood chemistry (electrolytes, glucose, renal function, liver ... and mentions that blood tests for vitamins D and B12, infectious diseases, and adrenal insufficiency may be warranted. The old ... and C-Reactive protein Iron tests Celiac disease screening Urinalysis for blood cells, protein and glucose In addition to the ...
Other changes in blood chemistry such as hypomagnesemia, hypocalcemia, hyperkalemia, and an increase in blood urea nitrogen ( ... Among the most common effects of this drug is increased blood cholesterol levels. ...
Serum glucose Calcium Blood urea nitrogen (BUN) Creatinine Electrolyte levels and the balance among them are tightly regulated ... Typically, the patient fasts for ten or twelve hours before the blood is drawn for the test-this is particularly important for ... The comprehensive metabolic panel, or chemical screen (CMP; CPT code 80053), is a panel of 14 blood tests that serves as an ... Sodium Potassium Chloride Carbon dioxide (CO2) Tests of protein levels in the blood help screen for both kidney and liver ...
Other factors that will influence the survival rate are the severity of proteinuria, blood urea nitrogen levels, serum creatine ... A blood test will be to measure the levels of creatine in the blood. An ultrasound will be done to see if there is inflammation ... If a patient is suspected to have DPGN, a blood and urine test will be done first. A urine test will be done to determine if ... They lead to rupturing of small blood vessels, ultimately causing necrosis and sclerosis. The glomeruli are the filters in the ...
BUN-to-creatinine ratio (the ratio of blood urea nitrogen to creatinine) can indicate other problems besides those intrinsic to ... A rise in blood creatinine concentration is a late marker, observed only with marked damage to functioning nephrons. Therefore ... It is released at a constant rate by the body (depending on muscle mass). Serum creatinine (a blood measurement) is an ... of kidney function can be made when interpreting the blood plasma concentration of creatinine along with that of urea. ...
The Labrador vomited several times and had increased blood urea nitrogen, total protein, and albumin concentrations with ... Despite these variables, the doses of smoke administered to these animals can be determined by examining tissue and blood ...
A moderate increase of aspartate aminotransferase, ALT, and blood urea nitrogen levels was observed whereas the ... in the sugar moiety was designed to have a nitrogen atom. This atom improves the formation of duplexes and triplexes by ...
... increased serum and urinary orotic acid levels and a decreased serum blood urea nitrogen level. This also leads to an increased ... It may be a symptom of an increased ammonia load due to a metabolic disorder, such as a urea cycle disorder. In ornithine ... when the reactions are run with bidentate nitrogen ligands such as 2,2'-bipyridine present other solids can be obtained. A ... transcarbamylase deficiency, an X-linked inherited and the most common urea cycle disorder, excess carbamoyl phosphate is ...
He discovered the urea cycle and later, working with Hans Kornberg, the citric acid cycle and the glyoxylate cycle. Modern ... Nitrogen is provided by glutamate and glutamine. Nonessensial amino acid synthesis depends on the formation of the appropriate ... Insulin is produced in response to rises in blood glucose levels. Binding of the hormone to insulin receptors on cells then ... The amino group is fed into the urea cycle, leaving a deaminated carbon skeleton in the form of a keto acid. Several of these ...
... of presentation is of varying severity ranging from early findings of proteinuria or small elevations in blood urea nitrogen ... systolic blood pressure, selenoprotein P serum levels, and hemoglobin A1c blood levels. Levels of LECT2 are also elevated in ... LECT2 has been detected in the blood and other tissues in a wide range of animal species from zebrafish to man. Furthermore, ... Blood levels of LECT2 in patients suffering bacterial sepsis correlated inversely with the severity of systemic inflammation ...
When there is no metal ion (or atom) bound to the nitrogens in the center, then the compounds are called free porphine or free ... One of the best-known families of porphyrin complexes is heme, the pigment in red blood cells, a cofactor of the protein ... selective and reusable catalyst for oxidation of alkenes and alkanes with urea-hydrogen peroxide". Journal of Experimental ... The inversion of one of the pyrrolic subunits in the macrocyclic ring resulted to face one of the nitrogen atom outside of the ...
2 HOCl Sodium hypochlorite reacts with most nitrogen compounds to form volatile monochloramine, dichloramines, and nitrogen ... including large blood spills (the area is first cleaned with detergent before being disinfected). It may be made by diluting ... urea, or related compounds and biological materials such as urine) produces chloramines. These gaseous products can cause acute ... producing chloramines and/or nitrogen trichloride. With excess ammonia and sodium hydroxide, hydrazine may be generated. ...
... urea - urea cycle - uric acid - UV/VIS spectroscopy vaccine - vacuole - valence - valine - van der Waals force - van der Waals ... nitrogen - nitroglycerine - Nobel Prize in Chemistry - non-competitive inhibition - nuclear lamina - nuclear localization ... blood proteins - boiling point - Boltzmann distribution - Boltzmann principle - bombesin - bombesin receptor - bone ...
The nitrogen cycle is a vital part of life, and is essential to carry out biosynthesis of nitrogen containing compounds. ... these bacteria spread through blood vessels and utilize the carbohydrates and proteins in the blood as an energy source. The ... Putrefying bacteria use amino acids or urea as an energy source to decompose dead organisms. In the process, they produce ... Decomposition Anaerobic organism Nitrogen Cycle Microbiome Putrefaction "4.10 Bacteria of the Nitrogen Cycle: Understanding for ...
She lectured and worked as an assistant to Hsien Wu, whose research initially focused on blood chemistry. She assisted in his ... Wu, Hsien; Wu, Daisy Yen (May 1950). "Influence of Feeding Schedule on Nitrogen Utilization and Excretion". Proceedings of the ... Wu, Daisy Yen; Wu, Hsien (January 1951). "Determination of Urea in Saliva". Proceedings of the Society for Experimental Biology ...
Blood Urea nitrogen greater than 7 mmol/L (19 mg/dL) Respiratory rate of 30 breaths per minute or greater Blood pressure less ... A variant of the CURB-65 that omits the urea measurement (CRB-65) is even simpler, as it relies only on history and examination ... However, the PSI is more complicated and requires arterial blood gas sampling amongst other tests; given this, the CURB-65 ... findings rather than blood tests. The CURB-65 is used as a means of deciding the action that is needed to be taken for that ...
Complete blood count (CBC) Blood urea nitrogen (BUN)/creatinine Liver function tests (LFTs) Glucose Amylase/lipase Urine ... Peritonitis Ectopic pregnancy Ovarian cysts Fluid/blood secondary to trauma Appendicitis Aneurysm KUB x-ray imaging (kidney, ... treatment Hemodynamic status and life-threatening disease require immediate attention Volume replacement with a possible blood ...
... multinutrient blocks may be used as a source of nitrogen and energy for animals. Urea is a nitrogen-based ... The Effect of Molasses/Mineral Feed Blocks along with the Use of Medicated Blocks on Haematological and Biochemical Blood ... Urea is a cheap source of nitrogen, in comparison with other sources, and adding urea to the molasses blocks will reduce the ... Urea is not a protein but it contains nitrogen which is capable of being used by the microbial population in the rumen to ...
1977 Urea for industrial use - Determination of nitrogen content - Titrimetric method after distillation [Withdrawn without ... Blood-taking sets for single use ISO 1135-4:2015 Part 4: Transfusion sets for single use, gravity feed ISO 1135-5:2015 Part 5: ... 1977 Urea for industrial use - Determination of ash ISO/R 1595:1970 Urea for industrial use - Determination of iron content - 2 ... Determination of nitrogen - Macro Kjeldahl method [Withdrawn without replacement] ISO 333:1996 Coal - Determination of nitrogen ...
... and blood urea nitrogen/creatinine ratio 30 or more. In the absence of these findings, a nasogastric aspirate can be considered ... Blood may be observed in vomit or in altered form as black stool. Depending on the amount of the blood loss, symptoms may ... The initial assessment includes measurement of the blood pressure and heart rate, as well as blood tests to determine the ... Fluid replacement, as well as blood transfusion, may be required. Endoscopy is recommended within 24 hours and bleeding can be ...
Nitrogen oxides (NO x, nitric oxide and nitrogen dioxide) In the tropopause, emissions of NO x favor ozone (O 3) formation in ... red blood cells, and cardiovascular and immune systems. Lead exposure in infants and young children may contribute to ... urea or other chemicals.: 42 During degradation in surface waters, ethylene and propylene glycol exert high levels of ... Nitrogen oxides (NO x) As designers work to reduce NO x emissions from jet engines, they fell by over 40% between 1997 and 2003 ...
... blood urea nitrogen (BUN), and creatinine levels, measuring arterial blood gases, chest radiography, electrocardiogram (ECG), ...
... nitrogen metabolism (urea cycle), and polyamine and nitric oxide (NO) synthesis (see illustration 'Agmatine Metabolic Pathways ... Rapid elimination from non-brain organs of ingested (un-metabolized) agmatine by the kidneys has indicated a blood half life of ... A year after its discovery, it was found that Agmatine could increase blood flow in rabbits; however, the physiological ... Agmatine produces mild reductions in heart rate and blood pressure, apparently by activating both central and peripheral ...
They should include a full blood count, blood urea nitrogen (BUN), creatinine, and liver function tests such as albumin, ... Routine blood tests are usually the next step in diagnosis after a thorough medical history and physical examination. ...
"Nitrogen Family". chemistry.tutorvista.com "Preparation of Nitrous Oxide from Urea, Nitric Acid and Sulfuric Acid". Suwa T, ... Nitrous oxide treatment was administered and licensed as a patent medicine by the likes of C. L. Blood and Jerome Harris in ... Nitrogen oxides, Monopropellants, Nicotinic antagonists, Nitrogen cycle, NMDA receptor antagonists, Rocket oxidizers, Trace ... It has a minimum alveolar concentration of 105% and a blood/gas partition coefficient of 0.46. The use of nitrous oxide in ...
For example: Cu + O 3 → CuO + O 2 Ag + O 3 → AgO + O 2 Ozone also oxidizes nitric oxide to nitrogen dioxide: NO + O 3 → NO 2 + ... If nitrite levels in the water are high, nitrites will also accumulate in the blood and tissues of fish, where it interferes ... CN− + O3 → CNO− + O2 Ozone will also completely decompose urea: (NH2)2CO + O3 → N2 + CO2 + 2 H2O Ozone is a bent triatomic ... In the clear atmosphere, with only nitrogen and oxygen, ozone can react with the atomic oxygen to form two molecules of O2 O 3 ...
Excess ammonia is processed in the liver through the urea cycle to produce urea. Excess ammonia can be produced by bacterial ... This causes the blood to skip the step of ammonia removal in the liver. Since the etiology is unconfirmed, diagnosis is ... The goal of these treatments is to convert nitrogen to a compound that can be excreted more easily. The mortality rate for THAN ... as well as a failure of the urea cycle to convert enough of the ammonia into urea. Since transamination of proteins is a ...
... also has a third substituent (triazolinone), which is joined to the morpholine ring nitrogen. It has three chiral ... Positron emission tomography (PET) studies, have demonstrated that aprepitant can cross the blood brain barrier and bind to NK1 ... brands, Morpholines, NK1 receptor antagonists, Triazoles, Trifluoromethyl compounds, Ureas, World Health Organization essential ... Common side effects include tiredness, loss of appetite, diarrhea, abdominal pain, hiccups, itchiness, pneumonia, and blood ...
Loss of nitrogen (urea) was observed already in the 1930s in fracture patients by the Scottish physician David Cuthbertson. The ... Höglund, OV; Hagman, R; Olsson, K; Olsson, U; Lagerstedt, AS (Aug 8, 2014). "Intraoperative Changes in Blood Pressure, Heart ... Examples of used parameters are blood pressure, heart rate, heart rate variability, photoplethysmography and skin conductance. ...
... urea/blood urea nitrogen, sodium, potassium, chloride, bicarbonate, calcium, magnesium, phosphate Glucose Amylase and lipase ... Because of impaired production of urea, blood urea does not represent the degree of kidney impairment.[citation needed] About ... Autoregulation of cerebral blood flow is impaired, and is associated with anaerobic glycolysis and oxidative stress. Neuronal ... Many centers use propofol for sedation because it may reduce cerebral blood. The head of the bed should be elevated to 30 ...
40-00-00 Methylene ureas (~70% slow release) 46-00-00 Urea (U-46) 82-00-00 Anhydrous ammonia 10-34-00 to 11-37-00 Ammonium ... The N value in NPK labels represents actual percentage of nitrogen element by weight, so it does not need to be converted. So, ... Organic Fish, Blood and Bone Feed - Harrod Horticultural (UK) (Use dmy dates from September 2021, Agricultural chemicals, ... The most common labeling convention, the NPK or N-P-K label, shows the amounts of the chemical elements nitrogen, phosphorus, ...
... increased urea formation, negative nitrogen balance Glaucoma due to increased ocular pressure Cataracts Topical steroid ... reduced muscle mass and repair Expansion of malar fat pads and dilation of small blood vessels in skin Lipomatosis within the ... likely due to hindrance of the ingestion of red blood cell by macrophage or other phagocyte. Increased urinary uric acid ... stimulates several processes that collectively serve to increase and maintain normal concentrations of glucose in the blood. ...
Their job is to filter the blood of metabolic waste and transport the urine via ureters to the urinary bladder where it is ... They have a urinary bladder and nitrogenous waste products are excreted primarily as urea. Most amphibians lay their eggs in ... Larvae and most aquatic adult amphibians excrete the nitrogen as ammonia in large quantities of dilute urine, while terrestrial ... In the juvenile (or tadpole) stage, the circulation is similar to that of a fish; the two-chambered heart pumps the blood ...
... blood urea nitrogen) test, which can provide important information about your kidney function. ... What is a BUN (Blood Urea Nitrogen) Test?. A BUN, or blood urea nitrogen test, can provide important information about your ... www.testing.com/tests/blood-urea-nitrogen-bun/. *Lyman JL. Blood urea nitrogen and creatinine. Emerg Med Clin North Am [ ... medlineplus.gov/lab-tests/bun-blood-urea-nitrogen/ BUN (Blood Urea Nitrogen). ...
The determination of serum creatinine and serum urea nitrogen levels is of great value in helping to ascertain the renal ... Blood urea nitrogen and creatinine J L Lyman. Emerg Med Clin North Am. 1986 May. ... Evaluation of blood urea nitrogen and serum creatinine concentrations as indicators of renal dysfunction: a study of 111 cases ... Tear urea nitrogen and creatinine levels in horse and their correlation with serum values. Zapata GL, Britos RM, Pintos ME, ...
Blood urea nitrogen testing is one of the common testing method perform to identify the proper functioning of the kidney and ... What is the Blood Urea Nitrogen Testing Market in the Healthcare Industry size at the regional and country-level? ... Blood Urea Nitrogen Testing Market Complete Analytical Report for 2029 with Key Players- OPTI Medical Systems, Inc., Abbott ... What are the strategies for growth adopted by the key players in Blood Urea Nitrogen Testing Market in the Healthcare Industry ...
Blood samples were taken before and after haemodialysis to measure blood urea nitrogen and serum creatinine, triiodothyronine ( ... Short communication: Creatinine, blood urea nitrogen and thyroid hormone levels before and after haemodialysis ... The aim of this study was to compare the serum levels of thyroid hormones T3 and T4 with blood urea nitrogen (BUN) and ... We suggest that a feedback relationship exists between the major end catabolic products (creatinine and blood urea nitrogen) ...
Blood urea nitrogen (mg/dL). Variable Name: LBXSBU. SAS Label: Blood urea nitrogen (mg/dL). English Text: Blood urea nitrogen ( ... Blood urea nitrogen (mmol/L). Variable Name: LBDSBUSI. SAS Label: Blood urea nitrogen (mmol/L). English Text: Blood urea ... Blood Urea Nitrogen (BUN). The DxC800 modular chemistry (BUNm) is used to quantitatively determine the concentration of blood ... 6. Blood Urea Nitrogen (BUN) BUN measurements are used in the diagnosis of certain renal and metabolic diseases. The ...
Creatinine, Blood Urea Nitrogen In controlled clinical trials minor increases in blood urea nitrogen and serum creatinine, ... increases in blood urea nitrogen and serum creatinine were observed in 20 percent of patients. These increases were almost ... Other causes of volume depletion such as vomiting or diarrhea may also lead to a fall in blood pressure; patients should be ... A patient whose blood pressure is not adequately controlled with either enalapril or hydrochlorothiazide monotherapy may be ...
Creatinine, Blood Urea Nitrogen. In controlled clinical trials minor increases in blood urea nitrogen and serum creatinine, ... Increases in blood urea nitrogen or creatinine were a cause for discontinuation in 1.2 percent of patients. ... increases in blood urea nitrogen and serum creatinine were observed in 20 percent of patients. These increases were almost ... increases in blood urea nitrogen or serum creatinine, usually reversible upon discontinuation of enalapril maleate and/or other ...
Interaction between loop diuretic-associated mortality and blood urea nitrogen concentration in chronic heart failure.. ... Interaction between loop diuretic-associated mortality and blood urea nitrogen concentration in chronic heart failure. J Am ... Home Publications Interaction between loop diuretic-associated mortality and blood urea nitrogen concentration in chronic heart ... blood urea nitrogen (BUN), could identify patients destined to experience adverse outcomes associated with the use of high-dose ...
Blood urea nitrogen. 151† 9-20 mg/dL. Creatinine. 13.7† 0.8-1.5 mg/dL. ...
Blood urea nitrogen. You may have a blood test for BUN to detect kidney disease problems.. ... Complete blood count. A blood test that measures many properties of the cells in your blood. ... Blood pressure. The force of your blood pushing against the walls of your arteries. ... A test that measures the amount of iron in your blood. TID. Three times a day Your doctor may write this on your prescription. ...
Blood urea nitrogen. 23. 18. NT. 17. 17. 63. 7-18 mg/dL. ...
... reflects the causal relation between anatomically evident arterial occlusive disease and elevated blood pressure. The ... Blood urea nitrogen (BUN) levels * Serum creatinine levels In addition, a fasting lipid panel and fasting glucose level are ... Guideline] National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The ... Blood oxygen level-dependent (BOLD) MRI in renovascular hypertension. Curr Hypertens Rep. 2011 Oct. 13(5):370-7. [QxMD MEDLINE ...
... activity and blood urea nitrogen from mice pretreated with buthionine sulfoximine and challenged with acetaminophen indicated ...
PL-02, LY-66, and OLP-01 increased tissue glycogen (liver and muscle) levels and muscle capillary density and reduced blood ... blood urea nitrogen (BUN), NH3, creatine kinase (CK), and glucose. On the 33rd day, 0.1 mL of blood was collected minutes after ... blood urea nitrogen; Crea, Creatinine; UA, Uric Acid; TP, total protein; CPK, Creatine Phosphokinase; Glu, Glucose. ... Lactate, BUN, CK, serum ammonia, and glucose levels in the blood were tested using an automatic blood analyzer (Hitachi 7060, ...
Creatinine, Blood Urea Nitrogen: Minor increases in blood urea nitrogen and serum creatinine, reversible upon discontinuation ... See PRECAUTIONS). Reversible minor increases in blood urea nitrogen and serum creatinine were observed in approximately 11.6% ... In hypertensive patients with unilateral or bilateral renal artery stenosis, increases in blood urea nitrogen and serum ... due to elevations in blood urea nitrogen and/or creatinine and 0.6% due to elevations in serum potassium. ...
Blood urea nitrogen (BUN) increased. 0.2%. Calcium decreased. 0.7%. Creatine phosphokinase increased ...
Blood urea nitrogen (BUN) and creatinine * Uric acid (will be elevated if the patient has high cell turnover or is dehydrated) ... Blood Studies. Perform a complete blood count (CBC) to determine if the patient has anemia, thrombocytopenia, or leukopenia. ... Biol Blood Marrow Transplant. 2009 Jan. 15(1):83-91. [QxMD MEDLINE Link]. ... Biol Blood Marrow Transplant. 2009 Jul. 15(7):812-6. [QxMD MEDLINE Link]. ...
... moderate significant increases in blood urea nitrogen were observed at exposure levels of 180 and 360 ppm, whereas moderate ... Mouse peripheral blood:. Positive in males and females. [a] These groups were not histopathologically examined.. N/A = not ...
... blood urea nitrogen; and creatinine. Other Procedures -- Perform a baseline visual acuity exam and test for red-green color ... blood urea nitrogen, and creatinine. -- To assist in the decision about the duration of TB treatment, investigate the ... Obtain a complete blood cell count, including platelets. -- Conduct chemistry panel tests, especially for liver enzyme levels ( ... Laboratory Tests -- Obtain a complete blood cell count, and also obtain a platelet count if the patient will be treated with a ...
BUN (Blood Urea Nitrogen): MedlinePlus Medical Test BUN (Blood Urea Nitrogen) What is a BUN (Blood Urea Nitrogen) Test? A BUN, ... BUN - blood test BUN stands for blood urea nitrogen. Urea nitrogen is what forms when protein breaks down. A test can be done ... Urea nitrogen urine test Urine urea nitrogen is a test that measures the amount of urea in the urine. Urea is a waste product ... Nitrogen test (image) Urea nitrogen urine test is performed to check for the amount of urea in urine. Urine is collected over ...
Collected blood were centrifuged for testing of blood urea nitrogen (BUN) and creatinine. Urine albumin was measured using the ... San Diego, CA, U.S.A.). Blood urea nitrogen (BUN), creatinine and Periodic acid-Schiff (PAS) Kits were acquired from Jiancheng ... Abbreviations: NC, normal control; CAR, carnosine; BUN, blood urea nitrogen; Cr, creatinine. ... Abbreviations: NC, normal control; CAR, carnosine; BUN, blood urea nitrogen; Cr, creatinine. ...
Blood urea nitrogen :(BUN) is a measurement of urea nitrogen, a waste material that the kidneys help eliminate from the blood. ... Blood Urea Nitrogen). Updated April 5, 2022. Accessed July 29, 2022. https://medlineplus.gov/lab-tests/bun-blood-urea-nitrogen/ ... Blood Urea Nitrogen (BUN). 6 to 20 mg/dL. 8 to 20 mg/dL. ... Blood Urea Nitrogen (BUN) Test Learn More * Calcium Test Learn ... A blood sample is needed for the CMP. All 14 measurements in the panel are conducted with the same sample, which is taken from ...
... blood lead; erythrocyte protoporphyrin; EP; urine arsenic; blood urea nitrogen; BUN ... Elevated blood urea nitrogen concentrations were found in 21 of 143 workers, possibly suggesting lead induced kidney disease. ... Blood lead concentrations of 60 micrograms per deciliter or above were found in 19 of 143 workers and 63 workers had ...
... blood-urea nitrogen, creatinine); biomarkers of infection and inflammation; metabolic by-products of drugs; concentrations of ... The requirement for obtaining blood samples and other biological specimens repeatedly leads to difficulty in obtaining IRB ... with obtaining blood or other products for clinical care and research in perinatal, neonatal, and pediatric patient populations ... care still involves performing painful needle punctures to obtain blood samples for routine clinical monitoring and to measure ...
When the blood urea nitrogen (BUN) level is adequately high (usually , 250-300 mg/dL), the concentration of urea in sweat is ... Because pruritus is not seen with acute renal failure, changes in blood urea nitrogen (BUN) and creatinine are not solely ... Evaporation results in the deposition of urea crystals on the skin. Uremic frost is commonly found in the beard or on other ... 33] Proximal shunting is attributed to the reversal of blood flow through distal arteries, induced by the low-pressure system ...
Blood Urea Nitrogen Actions. * Search in PubMed * Search in MeSH * Add to Search ... Juluri KR, Siu C, Cassaday RD. Juluri KR, et al. Blood Lymphat Cancer. 2022 May 30;12:55-79. doi: 10.2147/BLCTT.S342052. ... eCollection 2022. Blood Lymphat Cancer. 2022. PMID: 35669980 Free PMC article. Review. ...
MeSH Terms: Animals; Blood Urea Nitrogen; Cephaloridine/adverse effects; Cisplatin/adverse effects; Cysteine/adverse effects; ... exhibited significant elevations in blood urea nitrogen concentrations, which correlated with appearance of distinct renal ...
  • The BUN test measures the amount of urea nitrogen in your blood. (medlineplus.gov)
  • Urine urea nitrogen is a test that measures the amount of urea in the urine. (nih.gov)
  • The determination of serum creatinine and serum urea nitrogen levels is of great value in helping to ascertain the renal function in the clinical setting. (nih.gov)
  • The serum creatinine level is less influenced by extra-renal factors than is the serum urea nitrogen level, and is the more accurate test. (nih.gov)
  • Evaluation of blood urea nitrogen and serum creatinine concentrations as indicators of renal dysfunction: a study of 111 cases and a review of related literature. (nih.gov)
  • Blood samples were taken before and after haemodialysis to measure blood urea nitrogen and serum creatinine, triiodothyronine (T3) and thyroxine (T4) levels. (who.int)
  • Acute kidney injury (AKI), formerly called acute renal failure (ARF), is commonly defined as an abrupt decline in renal function, clinically manifesting as a reversible acute increase in nitrogen waste products (measured by blood urea nitrogen [BUN] and serum creatinine levels) over the course of hours to weeks. (medscape.com)
  • In male mice, moderate but significant increases in alanine aminotransferase and alkaline phosphatase were observed at exposure levels of 360 ppm, moderate significant increases in blood urea nitrogen were observed at exposure levels of 180 and 360 ppm, whereas moderate significant increases in serum creatinine were observed at exposure levels of 60, 180, and 360 ppm. (nih.gov)
  • Despite major advances, neonatal and pediatric intensive care still involves performing painful needle punctures to obtain blood samples for routine clinical monitoring and to measure and monitor serum electrolytes and other biochemical substances to assess the status of metabolic, kidney, hepatic, and cardio-respiratory systems. (nih.gov)
  • The basic metabolic panel (BMP) is a blood test that gives doctors information about the body's fluid balance, levels of electrolytes like sodium and potassium, and how well the kidneys are working. (kidshealth.org)
  • Urea nitrogen urine test is performed to check for the amount of urea in urine. (nih.gov)
  • Urine and blood tests are used to detect and monitor kidney disease. (nih.gov)
  • Blood, urine, and pregnancy tests will be performed. (nih.gov)
  • Acute liver failure is diagnosed through a full blood workup (hematology), biochemistry analysis, urine analysis, biopsy (the removal and analysis of affected tissue), and ultrasound or radiology imaging. (petmd.com)
  • Doctors order blood tests to check things such as the levels of glucose, hemoglobin, or white blood cells. (kidshealth.org)
  • Physicians may also use this test in consideration with the measured amounts of blood urea nitrogen, glucose, and sodium in your serum. (healthline.com)
  • The laboratory assessments of BUN levels and blood creatinine levels are "standard fare" in the assessment of renal function. (nih.gov)
  • The aim of this study was to compare the serum levels of thyroid hormones T3 and T4 with blood urea nitrogen (BUN) and creatinine serum levels in patients with chronic renal failure, before and after haemodialysis. (who.int)
  • OBJECTIVES: The purpose of this study was to investigate whether a surrogate for renal neurohormonal activation, blood urea nitrogen (BUN), could identify patients destined to experience adverse outcomes associated with the use of high-dose loop diuretics (HDLD). (nih.gov)
  • Rats given cephaloridine (1 g/kg), cisplatin (5 mg/kg), DCVC (100 mg/kg) or 2-BHQ (157 mg/kg) i.p. exhibited significant elevations in blood urea nitrogen concentrations, which correlated with appearance of distinct renal histopathological changes. (nih.gov)
  • The blood tests and urinalysis will be repeated 2 weeks after GnRH agonist administration to rule out any evidence of acute renal, hepatic or hematologic toxicity. (nih.gov)
  • The determination of serum urea nitrogen is the most widely used test for the evaluation of kidney function. (cdc.gov)
  • Blood lead concentrations of 60 micrograms per deciliter or above were found in 19 of 143 workers and 63 workers had concentrations of 40 to 59 micrograms per deciliter. (cdc.gov)
  • Elevated blood urea nitrogen concentrations were found in 21 of 143 workers, possibly suggesting lead induced kidney disease. (cdc.gov)
  • Tear urea nitrogen and creatinine levels in horse and their correlation with serum values. (nih.gov)
  • is a protein produced in the liver that transports important substances through the body and also keeps fluid from leaking out of blood vessels. (testing.com)
  • Urea nitrogen is what forms when protein breaks down. (nih.gov)
  • Urea is a byproduct of protein breaking down in the body. (healthline.com)
  • This results in more protein (nitrogen) waste, which the kidneys must remove from the blood stream. (pet-grub.com)
  • Blood urea nitrogen (BUN) is the blood test which measures this protein waste. (pet-grub.com)
  • Therefore, a high, cooked protein diet is more stressful on the kidneys and results in higher toxicity (BUN) in the blood if the kidneys are not functioning well. (pet-grub.com)
  • The main sources of calcium are dietary, but the mineral's levels in the blood do not normally fluctuate based on diet. (testing.com)
  • Instead, calcium in the blood is usually drawn from being stored in the bones. (testing.com)
  • Blood urea nitrogen testing is one of the common testing method perform to identify the proper functioning of the kidney and liver. (pharmiweb.com)
  • You may have a blood test for ALP to detect liver or bone disease. (nih.gov)
  • Plasma sorbitol dehydrogenase (SDH) activity and blood urea nitrogen from mice pretreated with buthionine sulfoximine and challenged with acetaminophen indicated that both liver and kidney injury had occurred. (nih.gov)
  • With 14 measurements, it can detect a range of abnormalities in blood sugar, nutrient balance, and liver and kidney health. (testing.com)
  • Sometimes, blood tests can help them see how well an organ (such as the liver or kidneys) is working. (kidshealth.org)
  • Interaction between loop diuretic-associated mortality and blood urea nitrogen concentration in chronic heart failure. (nih.gov)
  • Peripheral blood smears may show rouleau formation. (medscape.com)
  • Blood smears are also done to confirm the presences of the parasites within the red blood cells under a microscope. (nj.us)
  • Urea nitrogen is a waste product that your kidneys remove from your blood. (medlineplus.gov)
  • Normal BUN levels can vary, but generally a high level of blood urea nitrogen is a sign that your kidneys are not working well. (medlineplus.gov)
  • (BUN) is a measurement of urea nitrogen, a waste material that the kidneys help eliminate from the blood. (testing.com)
  • is a by-product of normal muscle activity, a waste product normally filtered and removed from the blood by the kidneys. (testing.com)
  • Blood urea nitrogen (BUN) and creatinine , which are waste products filtered out of the blood by the kidneys . (kidshealth.org)
  • is a measurement of the sum of albumin and globulins, which are proteins related to blood vessels and immune function. (testing.com)
  • The team of analysts at Future Market Insights are focussing on research and market study to produce different Blood Urea Nitrogen Testing Market forecasts and predictions at both national and international levels. (pharmiweb.com)
  • We suggest that a feedback relationship exists between the major end catabolic products (creatinine and blood urea nitrogen) and thyroid hormone serum levels. (who.int)
  • A CMP can also be used after a treatment has been started to see how your blood levels have changed. (testing.com)
  • Liquid nitrogen is a chemical that is extremely cold, about -328°F (-200°C). Liquid nitrogen will instantly freeze anything it touches. (nih.gov)
  • Diagnosis is made according to symptoms and by examining blood samples. (nj.us)
  • But if your provider has ordered other tests on your blood sample, you may need to fast (not eat or drink) for several hours before the test. (medlineplus.gov)
  • Contacts will have 4 visits over 8 months for blood tests and a physical exam. (nih.gov)
  • I have seen dramatic reductions in elevated kidney blood tests within two weeks in some patients. (pet-grub.com)
  • In clinical studies, the extent of blood pressure reduction seen with the combination of enalapril maleate and hydrochlorothiazide was approximately additive. (nih.gov)
  • The primary aim of this line of research is to develop approaches to reduce or eliminate pain and discomfort associated with obtaining blood or other products for clinical care and research in perinatal, neonatal, and pediatric patient populations. (nih.gov)
  • Univariate analyses and dose-response relations between hospital complications, laboratory data at ICU admission, arterial blood gas at ICU admission, worst arterial blood gas during ICU admission, and scores at hospitalization and degree of DLCO impairment at the follow-up. (archbronconeumol.org)
  • Drugs called ACE inhibitors are used to treat high blood pressure, heart failure, diabetes and kidney diseases. (nih.gov)
  • A comprehensive metabolic panel (CMP) is a blood test with 14 different measurements. (testing.com)
  • This is also known as blood sugar and may be elevated with metabolic problems like diabetes. (testing.com)
  • is a waste product that is yellowish in color and is produced from the breakdown of red blood cells. (testing.com)
  • You may have a blood test for CA-125 A to measure cancer activity. (nih.gov)
  • Haemodialysis employs the process of diffusion across a semi-permeable membrane to remove excretion products and excess fluids from the blood, while adding desirable components [2]. (who.int)
  • Primarily a disease in animals, babesiosis in rare cases can infect humans via a tick bite, transmission during a transfusion of blood products, or from an infected mother to her baby during pregnancy or delivery. (nj.us)
  • COVID-19 convalescent plasma will be obtained from the Jefferson Blood Bank and will meet all regulatory requirements for conventional plasma and FDA's additional considerations for COVID-19 convalescent plasma (https://www.fda.gov/vaccines-blood-biologics/investigational-new-drug-ind-or-device-exemption-ide-process-cber/investigational-covid-19-convalescent-plasma-emergency-inds). (clinicaltrials.gov)
  • is an electrolyte that reflects the level of carbon dioxide (CO2) in your blood. (testing.com)
  • While the mechanism through which enalapril maleate lowers blood pressure is believed to be primarily suppression of the renin-angiotensin-aldosterone system, enalapril maleate is antihypertensive even in patients with low-renin hypertension. (nih.gov)
  • Concomitant administration of lisinopril and hydrochlorothiazide further reduced blood pressure in Black and non-Black patients and any racial differences in blood pressure response were no longer evident. (nih.gov)
  • After the needle is inserted, a small amount of blood will be collected into a test tube or vial. (medlineplus.gov)
  • A needle will be inserted into the vein and a sample of your blood will draw into a vial. (healthline.com)
  • Over time, this may lead to serious health problems, including high blood pressure , anemia , and heart disease . (medlineplus.gov)
  • Perform a complete blood count (CBC) to determine if the patient has anemia, thrombocytopenia, or leukopenia. (medscape.com)
  • According to the CDC, because these parasites infect and destroy the red blood cells, it can cause a type of anemia known as hemolytic anemia. (nj.us)
  • A health care professional will take a blood sample from a vein in your arm, using a small needle. (medlineplus.gov)
  • Blood will be removed by needle in a vein in one arm. (nih.gov)
  • They'll use a needle to collect the blood, likely from a vein in your arm. (healthline.com)
  • If you have kidney disease , this waste material can build up in your blood. (medlineplus.gov)
  • A machine will remove white blood cells. (nih.gov)
  • Once the blood is collected the needle and elastic band will be removed from your arm. (healthline.com)
  • They may ask you to fast for six hours before your blood is drawn. (healthline.com)
  • Your doctor may also ask you to avoid taking certain drugs before your blood is drawn. (healthline.com)
  • Your doctor may order a blood osmolality test to check your body's salt/water balance. (healthline.com)
  • Babesiosis is an infection that attacks the red blood cells in humans. (nj.us)
  • Blood Urea Nitrogen Testing Market Complete Analytical Re. (pharmiweb.com)
  • A BUN, or blood urea nitrogen test, can provide important information about your kidney function. (medlineplus.gov)
  • All you need to do for this test is provide a sample of your blood. (healthline.com)