The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
Reinfusion of blood or blood products derived from the patient's own circulation. (Dorland, 27th ed)
The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.
Transplantation of an individual's own tissue from one site to another site.
The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.
Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.
Loss of blood during a surgical procedure.
The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.
In utero transfusion of BLOOD into the FETUS for the treatment of FETAL DISEASES, such as fetal erythroblastosis (ERYTHROBLASTOSIS, FETAL).
Centers for collecting, characterizing and storing human blood.
Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
Recovery of blood lost from surgical procedures for reuse by the same patient in AUTOLOGOUS BLOOD TRANSFUSIONS. It is collected during (intraoperatively) or after completion of (postoperatively) the surgical procedures.
Passage of blood from one fetus to another via an arteriovenous communication or other shunt, in a monozygotic twin pregnancy. It results in anemia in one twin and polycythemia in the other. (Lee et al., Wintrobe's Clinical Hematology, 9th ed, p737-8)
A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.
Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.
Antifibrinolytic hemostatic used in severe hemorrhage.
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders.
Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.
Members of a religious denomination founded in the United States during the late 19th century in which active evangelism is practiced, the imminent approach of the millennium is preached, and war and organized government authority in matters of conscience are strongly opposed (from American Heritage Dictionary of the English Language, 4th ed). Jehovah's Witnesses generally refuse blood transfusions and other blood-based treatments based on religious belief.
The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
The transfer of leukocytes from a donor to a recipient or reinfusion to the donor.
Reduction of blood viscosity usually by the addition of cell free solutions. Used clinically (1) in states of impaired microcirculation, (2) for replacement of intraoperative blood loss without homologous blood transfusion, and (3) in cardiopulmonary bypass and hypothermia.
The degree to which the blood supply for BLOOD TRANSFUSIONS is free of harmful substances or infectious agents, and properly typed and crossmatched (BLOOD GROUPING AND CROSSMATCHING) to insure serological compatibility between BLOOD DONORS and recipients.
The mildest form of erythroblastosis fetalis in which anemia is the chief manifestation.
The preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor.
Interventions to provide care prior to, during, and immediately after surgery.
Elements of limited time intervals, contributing to particular results or situations.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Substances that are used in place of blood, for example, as an alternative to BLOOD TRANSFUSIONS after blood loss to restore BLOOD VOLUME and oxygen-carrying capacity to the blood circulation, or to perfuse isolated organs.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.
A condition characterized by the abnormal presence of ERYTHROBLASTS in the circulation of the FETUS or NEWBORNS. It is a disorder due to BLOOD GROUP INCOMPATIBILITY, such as the maternal alloimmunization by fetal antigen RH FACTORS leading to HEMOLYSIS of ERYTHROCYTES, hemolytic anemia (ANEMIA, HEMOLYTIC), general edema (HYDROPS FETALIS), and SEVERE JAUNDICE IN NEWBORN.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
Bleeding or escape of blood from a vessel.
The removal of LEUKOCYTES from BLOOD to reduce BLOOD TRANSFUSION reactions and lower the chance of transmitting VIRUSES. This may be performed by FILTRATION or by CYTAPHERESIS.
Control of bleeding during or after surgery.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
International collective of humanitarian organizations led by volunteers and guided by its Congressional Charter and the Fundamental Principles of the International Red Cross Movement, to provide relief to victims of disaster and help people prevent, prepare for, and respond to emergencies.
Surgery which could be postponed or not done at all without danger to the patient. Elective surgery includes procedures to correct non-life-threatening medical problems as well as to alleviate conditions causing psychological stress or other potential risk to patients, e.g., cosmetic or contraceptive surgery.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
Transplacental passage of fetal blood into the circulation of the maternal organism. (Dorland, 27th ed)
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
The number of PLATELETS per unit volume in a sample of venous BLOOD.
Infectious organisms in the BLOOD, of which the predominant medical interest is their contamination of blood-soiled linens, towels, gowns, BANDAGES, other items from individuals in risk categories, NEEDLES and other sharp objects, MEDICAL WASTE and DENTAL WASTE, all of which health workers are exposed to. This concept is differentiated from the clinical conditions of BACTEREMIA; VIREMIA; and FUNGEMIA where the organism is present in the blood of a patient as the result of a natural infectious process.
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
Replacement of the knee joint.
A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
The process by which fetal Rh+ erythrocytes enter the circulation of an Rh- mother, causing her to produce IMMUNOGLOBULIN G antibodies, which can cross the placenta and destroy the erythrocytes of Rh+ fetuses. Rh isoimmunization can also be caused by BLOOD TRANSFUSION with mismatched blood.
Agents which improve the quality of the blood, increasing the hemoglobin level and the number of erythrocytes. They are used in the treatment of anemias.
The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.
The period of confinement of a patient to a hospital or other health facility.
Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Surgery performed on the heart.
A subnormal level of BLOOD PLATELETS.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
An infant during the first month after birth.
An excessive accumulation of iron in the body due to a greater than normal absorption of iron from the gastrointestinal tract or from parenteral injection. This may arise from idiopathic hemochromatosis, excessive iron intake, chronic alcoholism, certain types of refractory anemia, or transfusional hemosiderosis. (From Churchill's Illustrated Medical Dictionary, 1989)
Therapy of heavy metal poisoning using agents which sequester the metal from organs or tissues and bind it firmly within the ring structure of a new compound which can be eliminated from the body.
Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than 500 ml or of the amount that adversely affects the maternal physiology, such as BLOOD PRESSURE and HEMATOCRIT. Postpartum hemorrhage is divided into two categories, immediate (within first 24 hours after birth) or delayed (after 24 hours postpartum).
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Operations carried out for the correction of deformities and defects, repair of injuries, and diagnosis and cure of certain diseases. (Taber, 18th ed.)
A group of hereditary hemolytic anemias in which there is decreased synthesis of one or more hemoglobin polypeptide chains. There are several genetic types with clinical pictures ranging from barely detectable hematologic abnormality to severe and fatal anemia.
Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
The techniques used to draw blood from a vein for diagnostic purposes or for treatment of certain blood disorders such as erythrocytosis, hemochromatosis, polycythemia vera, and porphyria cutanea tarda.
The number of RETICULOCYTES per unit volume of BLOOD. The values are expressed as a percentage of the ERYTHROCYTE COUNT or in the form of an index ("corrected reticulocyte index"), which attempts to account for the number of circulating erythrocytes.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
Excision of all or part of the liver. (Dorland, 28th ed)
Replacement of the hip joint.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
INFLAMMATION of the LIVER in humans due to infection by VIRUSES. There are several significant types of human viral hepatitis with infection caused by enteric-transmission (HEPATITIS A; HEPATITIS E) or blood transfusion (HEPATITIS B; HEPATITIS C; and HEPATITIS D).
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
A rare transmissible encephalopathy most prevalent between the ages of 50 and 70 years. Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset. A familial form exhibiting autosomal dominant inheritance and a new variant CJD (potentially associated with ENCEPHALOPATHY, BOVINE SPONGIFORM) have been described. Pathological features include prominent cerebellar and cerebral cortical spongiform degeneration and the presence of PRIONS. (From N Engl J Med, 1998 Dec 31;339(27))
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.
EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.
Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
The return of a sign, symptom, or disease after a remission.
An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, FACTOR VIII, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agents such as APROTININ. Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, HEMOSTASIS, and WOUND HEALING.
The period during a surgical operation.
The indelible marking of TISSUES, primarily SKIN, by pricking it with NEEDLES to imbed various COLORING AGENTS. Tattooing of the CORNEA is done to colorize LEUKOMA spots.
The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.
Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.
The removal of fluids or discharges from the body, such as from a wound, sore, or cavity.
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate. The iron-binding porphyrin group of hemoglobin is an example of a metal chelate found in biological systems.
The religion stemming from the life, teachings, and death of Jesus Christ: the religion that believes in God as the Father Almighty who works redemptively through the Holy Spirit for men's salvation and that affirms Jesus Christ as Lord and Savior who proclaimed to man the gospel of salvation. (From Webster, 3d ed)
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Endoscopic examination, therapy or surgery of the fetus and amniotic cavity through abdominal or uterine entry.
Proteins prepared by recombinant DNA technology.
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.
Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
Bleeding from the nose.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Solutions having the same osmotic pressure as blood serum, or another solution with which they are compared. (From Grant & Hackh's Chemical Dictionary, 5th ed & Dorland, 28th ed)
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
A human infant born before 37 weeks of GESTATION.
The aggregate of various economic, political, and social policies by which an imperial power maintains or extends its control over other areas or peoples. It includes the practice of or belief in acquiring and retaining colonies. The emphasis is less on its identity as an ideological political system than on its designation in a period of history. (Webster, 3d ed; from Dr. J. Cassedy, NLM History of Medicine Division)
Surgical procedure involving either partial or entire removal of the spleen.
The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.
A test to detect non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells.
Use of a thrombelastograph, which provides a continuous graphic record of the physical shape of a clot during fibrin formation and subsequent lysis.
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the MONONUCLEAR PHAGOCYTE SYSTEM, without demonstrable tissue damage. The name refers to the presence of stainable iron in the tissue in the form of hemosiderin.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Disease having a short and relatively severe course.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
The insertion of a catheter through the skin and body wall into the kidney pelvis, mainly to provide urine drainage where the ureter is not functional. It is used also to remove or dissolve renal calculi and to diagnose ureteral obstruction.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.
The time periods immediately before, during and following a surgical operation.
Specialized hospital facilities which provide diagnostic and therapeutic services for trauma patients.
Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle cell conditions.
A space in which the pressure is far below atmospheric pressure so that the remaining gases do not affect processes being carried on in the space.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
Measurement of hemoglobin concentration in blood.
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Organized procedures for establishing patient identity, including use of bracelets, etc.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
A disease or state in which death is possible or imminent.
A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.
Acute hemorrhage or excessive fluid loss resulting in HYPOVOLEMIA.
Any procedure in which blood is withdrawn from a donor, a portion is separated and retained and the remainder is returned to the donor.
A detailed review and evaluation of selected clinical records by qualified professional personnel for evaluating quality of medical care.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
Yellow discoloration of the SKIN; MUCOUS MEMBRANE; and SCLERA in the NEWBORN. It is a sign of NEONATAL HYPERBILIRUBINEMIA. Most cases are transient self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) occurring in the first week of life, but some can be a sign of pathological disorders, particularly LIVER DISEASES.
A mucosal tumor of the urinary bladder or nasal cavity in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded than in other papillomas. (Stedman, 25th ed)
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.
The preparation of leukocyte concentrates with the return of red cells and leukocyte-poor plasma to the donor.
Acquired degenerative dilation or expansion (ectasia) of normal BLOOD VESSELS, often associated with aging. They are isolated, tortuous, thin-walled vessels and sources of bleeding. They occur most often in mucosal capillaries of the GASTROINTESTINAL TRACT leading to GASTROINTESTINAL HEMORRHAGE and ANEMIA.
A species of protozoa infecting humans via the intermediate tick vector IXODES scapularis. The other hosts are the mouse PEROMYSCUS leucopus and meadow vole MICROTUS pennsylvanicus, which are fed on by the tick. Other primates can be experimentally infected with Babesia microti.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
Laboratory tests for evaluating the individual's clotting mechanism.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Organic and inorganic compounds that contain iron as an integral part of the molecule.
A process of separating particulate matter from a fluid, such as air or a liquid, by passing the fluid carrier through a medium that will not pass the particulates. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
The restoration to life or consciousness of one apparently dead. (Dorland, 27th ed)
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
A condition of inadequate circulating red blood cells (ANEMIA) or insufficient HEMOGLOBIN due to premature destruction of red blood cells (ERYTHROCYTES).
Surgery performed on the ear and its parts, the nose and nasal cavity, or the throat, including surgery of the adenoids, tonsils, pharynx, and trachea.
The black, tarry, foul-smelling FECES that contain degraded blood.
The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.
The transference of a kidney from one human or animal to another.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.

Superior autologous blood stem cell mobilization from dose-intensive cyclophosphamide, etoposide, cisplatin plus G-CSF than from less intensive chemotherapy regimens. (1/329)

The study purpose was to determine if G-CSF plus dose-intensive cyclophosphamide 5.25 g/m2, etoposide 1.05 g/m2 and cisplatin 105 mg/m2 (DICEP) results in superior autologous blood stem cell mobilization (BSCM) than less intensive chemotherapy. From January 1993 until May 1997, 152 consecutive patients with non-Hodgkin's lymphoma (n = 55), breast cancer (n = 47), Hodgkin's disease (n = 14), multiple myeloma (n = 9), AML (n = 9), or other cancers (n = 18) initially underwent BSCM by one of three methods: Group 1: G-CSF alone x 4 days (n = 30). Group 2: disease-oriented chemotherapy, dosed to avoid blood transfusions, followed by G-CSF starting day 7 or 8, and apheresis day 13 or 14 (n = 82). Group 3: DICEP days 1-3, G-CSF starting day 14, and apheresis planned day 19, 20 or 21 (n = 40). A multivariate analysis was performed to determine which factors independently predicted BSCM. The median peripheral blood CD34+ (PB CD34+) cell count the morning of apheresis linearly correlated with the number of CD34+ cells removed per litre of apheresis that day. The median PB CD34+ cell count and median CD34+ cells x 10(6) removed per litre of apheresis were highest for Group 3, intermediate for Group 2, and lowest for Group 1. By multivariate analysis, mobilization group (3 > 2 > 1), disease other than AML, no prior melphalan or mitomycin-C, and less than two prior chemotherapy regimens predicted better BSCM. Out of 15 Group 3 patients who had infiltrated marrows, 11 had no detectable cancer in marrow and apheresis products after DICEP. These data suggest that DICEP results in superior BSCM than less intensive chemotherapy regimens.  (+info)

Autologous versus allogeneic transfusion: patients' perceptions and experiences. (2/329)

BACKGROUND: Preoperative autologous donation is one way to decrease a patient's exposure to allogeneic blood transfusion. This study was designed to determine patients' perceptions about the autologous blood donation process and their experiences with transfusion. METHODS: To assess patient perception, a questionnaire was administered a few days before surgery to patients undergoing elective cardiac and orthopedic surgery in a Canadian teaching hospital. All patients attending the preoperative autologous donation clinic during a 10-month period were eligible. A convenience sample of patients undergoing the same types of surgery who had not predonated blood were selected from preadmission clinics. Patient charts were reviewed retrospectively to assess actual transfusion practice in all cases. RESULTS: A total of 80 patients underwent cardiac surgery (40 autologous donors, 40 nondonors) and 73 underwent orthopedic surgery (38 autologous donors, 35 nondonors). Of the autologous donors, 75 (96%) attended all scheduled donation appointments, 73 (93%) said that they were "very likely" or "likely" to predonate again, and 75 (96%) said that they would recommend autologous donation to others. There was little difference in preoperative symptoms between the autologous donors and the nondonors, although the former were more likely than the latter to report that their overall health had remained the same during the month before surgery (30 [75%] v. 21 [52%] for the cardiac surgery patients and 30 [79%] v. 18 [51%] for the orthopedic surgery patients). When the autologous donors were asked what they felt their chances would have been of receiving at least one allogeneic blood transfusion had they not predonated, the median response was 80%. When they were asked what their chances were after predonating their own blood, the median response was 0%. The autologous donors were significantly less likely to receive allogeneic blood transfusions (6 [15%] for cardiac surgery and 3 [8%] for orthopedic surgery) than were the nondonors (14 [35%] for cardiac surgery and 16 [46%] for orthopaedic surgery). They were, however, more likely to receive any transfusion (autologous or allogeneic) than were the nondonors (25 [63%] v. 14 [35%] for cardiac surgery and 31 [81%] v. 16 [46%] for orthopedic surgery). INTERPRETATION: Patients who underwent preoperative autologous blood donation were positive about the experience and did not report more symptoms than patients who did not donate blood preoperatively. Autologous donors overestimated their chances of receiving allogeneic blood transfusions had they not predonated and underestimated their chances after they had predonated. They were less likely to receive allogeneic transfusions, but more likely to receive any type of transfusion, than were patients who did not predonate.  (+info)

Transfusion practices among patients who did and did not predonate autologous blood before elective cardiac surgery. (3/329)

BACKGROUND: Preoperative autologous blood donation is commonly used to reduce exposure to allogeneic transfusions among patients undergoing elective cardiac surgery. However, this technique is associated with an overall increase in transfusions (allogeneic or autologous). The authors assessed the impact of transfusion decision-making on the effectiveness of preoperative autologous donation in reducing the frequency of allogeneic transfusions, and its impact on the increased transfusion rate associated with preoperative autologous donation in cardiac surgery. METHODS: This retrospective analysis compared transfusion practices among 176 patients who predonated autologous blood before elective cardiac surgery and 176 matched cardiac surgery patients who did not predonate blood. The impact of decision-making on transfusion exposure was determined using multivariate analyses to account for major perioperative interventions and complications. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for exposure to allogeneic blood transfusion or any transfusion, before and after exclusion of transfusions not conforming with selected transfusion criteria. RESULTS: Exposure to allogeneic transfusion was more likely among patients who did not predonate blood than among those who did predonate blood (OR 14.0, 95% CI 5.8-33.8). This finding was still true after exclusion of transfusions not meeting the transfusion criteria (OR 19.3, 95% CI 6.7-55.7). The autologous blood donors were more likely than the nondonors to receive any transfusion (OR 10.8, 95% CI 5.7-20.3). However, this association was substantially attenuated after exclusion of transfusions not meeting the transfusion criteria (OR 1.9, 95% CI 1.1-3.2). INTERPRETATION: Patients who predonated blood before elective cardiac surgery were at lower risk of receiving allogeneic transfusions than the nondonors. This was not because of a deliberate withholding of allogeneic transfusions from autologous donors. However, more liberal transfusion criteria for autologous blood were largely responsible for the increased transfusion rate among the autologous donors.  (+info)

Complement activation and increased systemic and pulmonary vascular resistance indices during infusion of postoperatively drained untreated blood. (4/329)

In nine healthy young patients, operated on for thoracic scoliosis, a pulmonary artery catheter was inserted for the study of haemodynamic variables and blood sampling during autologous transfusion of postoperatively drained blood. At 1-3 h after wound closure, 10 ml kg/body weight of drained untreated blood from the wound was collected and recirculated over a l-h period. The concentration of the complement activation product, C3bc, increased from a mean of 5.4 (SD 1.5) AU ml-1 before infusion to 11.1 (3.9) AU ml-1 during infusion and then returned to 7.8 (2.8) AU ml-1 after infusion. The concentration of the terminal complement complex (TCC) increased from 0.5 (0.2) to 1.3 (0.5) AU ml-1 and was reduced to 0.7 (0.3) AU ml-1 after infusion. Only TCC exceeded the reference values which are 14 AU ml-1 for C3bc and 1.0 AU ml-1 for TCC. Pulmonary vascular resistance index concomitantly increased from a mean of 130 (SD 52) to 195 (88) dyn s cm-5 m-2 and was reduced to 170 (86) dyn s cm-5 m-2 after infusion. Systemic vascular resistance index increased from a mean of 1238 (SD 403) to 1349 (473) dyn s cm-5 m-2 and returned to 1196 (401) dyn s cm-5 m-2 after infusion. White blood cell count (WCC) increased from 14.4 (4.3) x 10(9) litre-1 before infusion to 17.8 (7.2) x 10(9) litre-1 during and after infusion. No change in platelet count during infusion was observed. There were no differences in WCC or platelet count between mixed venous or peripheral arterial blood. Pulmonary and systemic vascular resistance indices may be influenced by activated complement in drained untreated blood when it is recirculated.  (+info)

Haemodynamic assessment of hypovolaemia under general anaesthesia in pigs submitted to graded haemorrhage and retransfusion. (5/329)

We have compared the value of different variables used in the assessment of blood loss during progressive hypovolaemia and resuscitation under general anaesthesia in anaesthetized pigs. We measured mean arterial pressure (MAP), pulmonary capillary wedge pressure (PCWP), the negative component of the systolic arterial pressure variation (delta Down) and left ventricular end-diastolic area (LVEDa) using echocardiography. Blood was progressively withdrawn (up to 35 ml kg-1 in seven steps) and then reinfused after the same pattern. Regression coefficient (r) and normalized slope (nS) of the regression relationship between each variable and amount of blood loss were determined. The difference between the withdrawal and reinfusion curves was assessed by the area between the curves. We also estimated the minimal loss of blood volume which induced significant changes in each variable compared with that under control conditions during withdrawal of blood (minWBV) and maximal loss in blood volume which induced no significant changes in a variable compared with control conditions during retransfusion (maxRBV). During haemorrhage, MAP decreased (from mean 74 (SD 9) to 31 (5) mm Hg; P < 0.001), delta Down increased (from 1.2 (1.4) to 11.4 (4.2) mm Hg; P < 0.001), PCWP decreased (from 6.2 (2.1) to 0.3 (1.0) mm Hg; P < 0.001) and LVEDa decreased (from 13.8 (2.0) to 5.1 (2.0) cm2; P < 0.01). The highest r values were obtained with MAP and LVEDa, and the highest nS value with delta Down. The least difference between withdrawal and reinfusion was with LVEDa, the lowest values of minWBV were with PCWP and LVEDa, and the highest value of maxRBV was obtained with PCWP. During progressive haemorrhage under general anaesthesia, LVEDa was an accurate variable for assessment of blood volume loss, delta Down contributed no further information compared with MAP, and PCWP was the most reliable variable for assessing return to baseline blood volume.  (+info)

Systemic and microcirculatory effects of autologous whole blood resuscitation in severe hemorrhagic shock. (6/329)

Systemic and microcirculatory effects of autologous whole blood resuscitation after 4-h hemorrhagic shock with a mean arterial pressure (MAP) level of 40 mmHg were investigated in 63 conscious Syrian golden hamsters. Microcirculation of skeletal skin muscle and subcutaneous connective tissue was visualized in a dorsal skinfold. Shed blood was retransfused within 30 min after 4 h. Animals were grouped into survivors in good (SG) and poor condition (SP) and nonsurvivors (NS) according to 24-h outcome after resuscitation and studied before shock, during shock (60, 120, and 240 min), and 30 min and 24 h after resuscitation. Microvascular and interstitial PO2 values were determined by phosphorescence decay. Shock caused a significant increase of arterial PO2 and decrease of PCO2, pH, and base excess. In the microcirculation, there was a significant decrease in blood flow (QB), functional capillary density (FCD; capillaries with red blood cell flow), and interstitial PO2 [1.8 +/- 0.8 mmHg (SG), 1.3 +/- 1.3 mmHg (SP), and 0.9 +/- 1.1 mmHg (NS) vs. 23.0 +/- 6.1 mmHg at control]. Blood resuscitation caused immediate MAP recompensation in all animals, whereas metabolic acidosis, hyperventilation, and a significant interstitial PO2 decrease (40-60% of control) persisted. In NS (44.4% of the animals), systemic and microcirculatory alterations were significantly more severe both in shock and after resuscitation than in survivors. Whereas in SG (31.8% of the animals) there was only a slight (15-30%) but still significant impairment of microscopic tissue perfusion (QB, FCD) and oxygenation at 24 h, SP (23.8% of the animals) showed severe metabolic acidosis and substantial decreases (>/=50%) of FCD and interstitial PO2. FCD, interstitial PO2, and metabolic state were the main determinants of shock outcome.  (+info)

A prospective randomized comparison of three blood conservation strategies for radical prostatectomy. (7/329)

BACKGROUND: Preoperative autologous blood donation is a standard of care for elective surgical procedures requiring transfusion. The authors evaluated the efficacy of alternative blood-conservation strategies including preoperative recombinant human erythropoietin (rHuEPO) therapy and acute normovolemic hemodilution (ANH) in radical retropubic prostatectomy patients. METHODS: Seventy-nine patients were prospectively randomized to preoperative autologous donation (3 U autologous blood); rHuEPO plus ANH (preoperative subcutaneous administration of 600 U/kg rHuEPO at 21 and 14 days before surgery and 300 U/kg on day of surgery followed by ANH in the operating room); or ANH (blinded, placebo injections per the rHuEPO regimen listed previously). Transfusion outcomes, perioperative hematocrit levels, postoperative outcomes, and blood-conservation costs were compared among the three groups. RESULTS: Baseline hematocrit levels were similar in all groups (43%+/-2%). On the day of surgery hematocrit decreased to 34% +/-4% in the preoperative autologous donation group (P < 0.001), increased to 47%+/-2% in the rHuEPO plus ANH group (P < 0.001), and remained unchanged at 43%+/-2% in the ANH group. Allogeneic blood exposure was similar in all groups. The rHuEPO plus ANH group had significantly higher hematocrit levels compared with the other groups throughout the hospitalization (P < 0.001). Average transfusion costs were significantly lower for ANH ($194+/-$192) compared with preoperative autologous donation ($690+/-$128; P < 0.001) or rHuEPO plus ANH ($1,393+/-$204, P < 0.001). CONCLUSIONS: All three blood-conservation strategies resulted in similar allogeneic blood exposure rates, but ANH was the least costly technique. Preoperative rHuEPO plus ANH prevented postoperative anemia but resulted in the highest transfusion costs.  (+info)

Perflubron emulsion delays blood transfusions in orthopedic surgery. European Perflubron Emulsion Study Group. (8/329)

BACKGROUND: Fluorocarbon emulsions have been proposed as temporary artificial oxygen carriers. The aim of the present study is to compare the effectiveness of perflubron emulsion with the effectiveness of autologous blood or colloid infusion for reversal of physiologic transfusion triggers. METHODS: A multinational, multicenter, randomized, controlled, single-blind, parallel group study was performed in 147 orthopedic patients. Patients underwent acute normovolemic hemodilution with colloid to a target hemoglobin of 9 g/dl with an inspiratory oxygen fraction (FIO2) of 0.40. Patients were then randomized into one of four treatment groups after having reached any of the protocol-defined transfusion triggers including tachycardia (heart rate > 125% of posthemodilution rate or > 110 bpm), hypotension (mean arterial pressure < 75% of posthemodilution level or < or = 60 mmHg), elevated cardiac output (> 150% of posthemodilution level) or decreased mixed venous oxygen partial pressure (PVO2; < 38 mmHg). Treatments in the four groups were 450 ml autologous blood harvested during acute normovolemic hemodilution given at FO2 = 0.40; 450 ml colloid at FIO2 = 1.0; 0.9 g/kg perflubron emulsion with colloid (total = 450 ml) at FIO2 = 1.0; and 1.8 g/kg perflubron emulsion with colloid (total = 450 ml) at FIO2 = 1.0. The primary endpoint was duration of transfusion-trigger reversal. A secondary end-point was percentage of transfusion-trigger reversal. RESULTS: Perflubron emulsion was well tolerated with no serious adverse event attributed to drug treatment. Duration of reversal was longest in the 1.8 g/kg perflubron group (median, 80 min; 95% confidence interval, 60-100 min; P = 0.014 vs. autologous blood, P < 0.001 vs. colloid) followed by the 0.9 g/kg perflubron group (median, 59 min; 95% confidence interval, 40-90 min), the autologous blood group (median, 55 min; 95% confidence interval, 30-70 min) and the colloid group (median, 30 min; 95% confidence interval, 27-60 min). Percentage of reversal was also highest in the 1.8 g/kg perflubron group (97%; P < 0.001 vs. autologous blood; P = 0.014 vs. colloid), followed by 0.9 g/kg perflubron (82%), colloid (76%), and autologous blood (60%). CONCLUSIONS: Perflubron emulsion (1.8 g/kg) combined with 100% oxygen ventilation is more effective than autologous blood or colloid infusion in reversing physiologic transfusion triggers.  (+info)

UNLABELLED The erythropoietic capacity for preoperative autologous blood donation (ECPABD) shows marked inter individual variability. This study was performed to evaluate factors useful to predict individual ECPABD from data available before the first donation. The subjects consisted of 74 adult patients who received autologous blood donation, with a mean of 61 +/- 12.8 yr (SD). We classified the patients into four groups using our criteria for evaluating the ECPABD and investigated the relationships among age, disease, pre-platelet count, and the rate of platelet increase. RESULTS (1) Advanced age and the status of disease were not distinctly correlated with low ECPABD. (2) Patients with a high pre-platelet levels had a low ECPABD regardless of the haemoglobin. (3) Patients in which the platelet count increased in accordance with the level of collection exhibited low pre-platelet counts and high ECPABD. CONCLUSION In patients with high pre-platelet levels, we reduced the amount collected,
TY - JOUR. T1 - The Failure of Retrograde Autologous Priming of the Cardiopulmonary Bypass Circuit to Reduce Blood Use after Cardiac Surgical Procedures. AU - Murphy, Glenn S.. AU - Szokol, Joseph W.. AU - Nitsun, Martin. AU - Alspach, David A.. AU - Avram, Michael J.. AU - Vender, Jeffery S.. AU - Votapka, Timothy V.. AU - Rosengart, Todd K.. PY - 2004/5. Y1 - 2004/5. N2 - Hemodilution during cardiopulmonary bypass (CPB) is a primary risk factor for blood transfusion in cardiac surgical patients. Priming of the CPB circuit with the patients own blood (retrograde autologous priming, RAP) is a technique used to limit hemodilution and reduce transfusion requirements. We designed this study to examine the impact of RAP on perioperative blood product use. Using a retrospective cohort study design, the medical records of all patients undergoing CPB (excluding circulatory arrest cases) by a single surgeon were examined. Data were collected over a 24-mo period when RAP was routinely used as a blood ...
Objective: Mediastinal bleeding and blood transfusion have been an important accompaniment of open heart surgery. Increasing attempts are being made to minimize blood loss and blood transfusion in cardiac surgery. We investigated the effect of intraoperative autologous donation (IAD) on need for homologous transfusion post-coronary artery bypass graft surgery (CABG).Methods: 202 adult patients scheduled for elective CABG operation were randomly assigned to IAD (n=101) or control groups (n=101). We obtained 500ml fresh whole blood from the IAD patients while the patients were prepared for anesthesia in the operating room. This amount of blood was replaced with Ringers solution. After completion of the operation and neutralization of heparin, this blood was re-infused to the patients. The amount of bleeding and infused blood products were measured and compared in both groups.Results: The present study demonstrated that IAD did not significantly reduce post-operative mediastinal bleeding, although it had
Behaviorally associated changes in neuroconnectivity following autologous umbilical cord blood infusion in young children with autism spectrum disorder
PURPOSE: This study tested the hypothesis that autologous blood transfusion (ABT) of ~50% of the red blood cells (RBC) from a standard 450-mL phlebotomy would increase mean power in a cycling time trial. In addition, the study investigated whether further ABT of RBC obtained from another 450-mL phlebotomy would increase repeated cycling sprint ability.. METHODS: In a randomized, double-blind, placebo-controlled crossover design (3-month wash-out), nine highly trained male subjects donated two 450-mL blood bags each (BT trial) or were sham phlebotomized (PLA trial). Four weeks later, a 650-kcal time trial (n = 7) was performed 3 d before and 2 h after receiving either ~50% (135 mL) of the RBC or a sham transfusion. On the following day, transfusion of RBC (235 mL) from the second donation or sham transfusion was completed. A 4 × 30-s all-out cycling sprint interspersed by 4 min of recovery was performed 6 d before and 3 d after the second ABT (n = 9).. RESULTS: The mean power was increased in ...
TY - JOUR. T1 - Detection of homologous blood transfusion. AU - Voß, Sven. AU - Thevis, Mario. AU - Schinkothe, T.. AU - Schänzer, Wilhelm. PY - 2007. Y1 - 2007. N2 - The aim of the present study was to improve and validate a flow cytometric method for the detection of homologous blood transfusion in doping control analysis. A panel of eight different primary antibodies and two different phycoerythrin-conjugated secondary antibodies was used for the detection of different blood populations. The flow cytometer used in this study was the BD FACSArray® instrument. Mixed red blood cell populations were prepared from phenotype known donors. Linearity, specificity, recovery, precision, robustness and interday-precision were tested for every primary antibody used in the presented assay. The technique of signal amplification was utilized for an improved separation of antigens with weak or heterozygous expression to improve the interpretation of histograms. The resulting method allowed to clearly ...
Fingerprint Dive into the research topics of The influence of intraoperative autotransfusion on postoperative hematocrit after cardiac surgery: A cross-sectional study. Together they form a unique fingerprint. ...
Autotransfusion is a process wherein a person receives their own blood for a transfusion, instead of banked allogenic (separate-donor) blood. There are two main kinds of autotransfusion: Blood can be autologously pre-donated (termed so despite donation not typically referring to giving to ones self) before a surgery, or alternatively, it can be collected during and after the surgery using an intraoperative blood salvage device (such as a Cell Saver or CATS). The latter form of autotransfusion is utilized in surgeries where there is expected a large volume blood loss - e.g. aneurysm, total joint replacement, and spinal surgeries. The first documented use of self-donated blood was in 1818, and interest in the practice continued until the Second World War, at which point blood supply became less of an issue due to the increased number of blood donors. Later, interest in the procedure returned with concerns about allogenic (separate-donor) transfusions. Autotransfusion is used in a number of ...
Cognitive function was assessed in English-speaking study participants using one of three different tools depending on the age of the patient at the time of assessment: The Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III), the Wechsler Intelligence Scale for Children (WISC-IV), and the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III). Some patients were assessed with different tools at subsequent visits as they aged during the conduct of the trial. There are two versions of the WPPSI-III for two different age ranges: 2 years & 6 months to 3 years & 11 months, and 4 years to 7 years & 3 months. The Full Scale IQ is calculated for both age ranges and provides a continuous score with an average of 100 and a standard deviation of 15. Change from Baseline to Year 1 was evaluated, with positive numbers indicating an increase in cognitive ability, negative numbers indicating a decrease in cognitive ability, and zero indicating no change ...
Cognitive function was assessed in English-speaking study participants using one of three different tools depending on the age of the patient at the time of assessment: The Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III), the Wechsler Intelligence Scale for Children (WISC-IV), and the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III). Some patients were assessed with different tools at subsequent visits as they aged during the conduct of the trial. There are two versions of the WPPSI-III for two different age ranges: 2 years & 6 months to 3 years & 11 months, and 4 years to 7 years & 3 months. The Full Scale IQ is calculated for both age ranges and provides a continuous score with an average of 100 and a standard deviation of 15. Change from Baseline to Year 1 was evaluated, with positive numbers indicating an increase in cognitive ability, negative numbers indicating a decrease in cognitive ability, and zero indicating no change ...
[120 Pages Report] Check for Discount on 2015-2025 Global Cardiopulmonary Autotransfusion System Market Research by Type, End-Use and Region (COVID-19 Version) report by 99Strategy. Summary Cardiopulmonary Autotransfusion System is a sophisticated device with an...
The Consensus Document on Alternatives to Allogenic Blood Transfusion (AABT) has been drawn up by a panel of experts from 5 scientific societies. The Seville Consensus Document on Alternatives to Allogenic Blood Transfusion
Preoperative autologous collections are most beneficial to those patients who are undergoing procedures with substantial anticipated blood loss, such as orthopedic joint replacement, vascular surgery, cardiac or thoracic surgery, and radical prostatectomy. Autologous blood is unnecessary for procedures that seldom require transfusion, such as transurethral resection of the prostate, cholecystectomy, herniorrhaphy, vaginal hysterectomy, and uncomplicated obstetric delivery [14]. A hospitals maximal surgical blood order schedule for blood cross-match can provide estimates of transfusion rates for specific procedures; the generally accepted cutoff at which transfusion is unlikely and autologous blood procurement should not be recommended is 10% [15].. Collection of units should be scheduled as far in advance of surgery as possible for liquid blood storage (up to 42 days), to allow compensatory erythropoiesis [5] to correct the induced anemia. If the erythropoietic response to autologous blood ...
When used as the sole source of transfused blood, the principal advantage of autologous blood transfusion is the avoidance of transmission of infectious agents and the avoidance of the purported adverse immunomodulatory effects of allogeneic transfusion. In the 1990s, however, the risks of transfusion-transmitted diseases have been greatly reduced, and estimates of the cost-effectiveness of pre-operative autologous blood donations now vary between 2470 dollars and 3,400,000 dollars per quality-adjusted year of life saved, depending on assumptions about the existence and magnitude of any adverse immunomodulatory effects of allogeneic transfusion. There is a paucity of randomized controlled trials evaluating the clinical outcomes and the cost-effectiveness of autologous transfusion procedures, and this situation is unlikely to change in the near future because of the difficulties in conducting such trials. Read More ...
Autologous Blood Injection (ABI), also known as Autologous Conditioned Plasma (ACP) Injection is a medical procedure popularized circa 2000, whereby a patients blood is injected into an area of the body for the purposes of healing.. ABI is most commonly used to treat degeneration of tendons, which may occur in association with small tears. This disorder of tendons is frequently referred to as tendinitis by the public, however is known as tendinosis or tendinopathy in the medical profession. The procedure is usually performed under ultrasound control by a radiologist.[1] The injection of blood contains small cells called platelets, which contain platelet derived growth factor. This substance is thought to promote tendon healing. A variation on the technique is platelet rich plasma (PRP),[2] which is where the whole blood removed from the patient is spun in a centrifuge, separating the cells of the blood. As such a higher concentration of platelets is delivered into the tissue for healing. As ...
The global Autotransfusion Systems Market is poised to reach USD 505 million by 2024. Autotransfusion Products Market Report provides crucial industry insights that will help your business grow.
An autologous blood transfusion system comprising at least two interconnected blood receptacles, the first of which is evacuated and connected to a suction device for aspirating blood. The second receptacle takes blood from the first by overcoming the vacuum in the first with a greater vacuum in the second without interrupting the ability of the suction device to simultaneously aspirate blood. The second receptacle may comprise a transfer bag for reinfusion into the patient or an infusion set may be connected to the second receptacle to permit simultaneous collection of the blood from the patient and infusion of the blood back into the patient. In either case, the second receptacle is selectively exposed to positive pressure to expel the blood from the second receptacle into the transfer bag or patient. The method includes aspirating blood from the patient and collecting blood in the first receptacle. Blood is thereafter transferred to the second receptacle by increasing the vacuum in the second
Article] Journal of Orthopaedic Trauma. 29(8):349-353, August 2015. (Format: HTML, PDF). Objective: To determine if intraoperative autologous transfusion using a Cell Saver (CS) was routinely indicated for open reduction internal fixation (ORIF) of acetabular fractures, and if so, was there a difference between differing surgical approaches.. Design: Retrospective single-center cohort study.. Setting: University Level 1 trauma center.. Patients/Participants: One hundred forty-five consecutive acetabular fractures using intraoperative autologous transfusion, either treated with an anterior ilioinguinal or a posterior-based Kocher-Langenbeck approach, were compared.. Intervention: Use of CS in ORIF acetabular cases.. Main Outcome Measurements: CS utilization and CS blood return for acetabular ORIF. Mean intraoperative blood loss between the 2 approaches.. Results: CS blood was returned in 29 of the 145 total cases [23/65 anterior (ilioinguinal approach) and 6/80 posterior approach ...
The most common autologous donation is the preoperative donation of blood for possible use by the donor during elective surgery. For example, a person might give one unit of blood each week for up to six weeks before surgery,(because blood can be stored in its liquid form for up to 42 days). Patients cannot make autologous donations after 72 hours prior to their surgery so that the body has enough time to replenish its blood volume before the surgical procedure.. A significant amount of iron is removed with each autologous donation. As a result, iron supplements are often prescribed for patients making autologous donations.. Autologous donation is most often employed in surgery on bones, blood vessels, the urinary tract, and the heart, when the likely need for transfusion is high. Autologous blood accounts for nearly 5 percent of all blood donated. Autologous blood donors must be medically stable patients who are free of infection. There is no age limitation and many children and elderly ...
Autologous blood donation - can we bank on it? Occupational exposure to blood among medical students. Risks to health care workers in developing countries
Since the successful perioperative use of rhEPO more than 5 years ago in an animal model, many reports (1) have detailed its use in clinical medicine. The investigation by Biesma and colleagues joins a growing list of studies that support the preoperative clinical use of rhEPO as an adjunct to decrease allogeneic (homologous) red blood cell use (1, 2). Their study is also unique in that it helps to define specific groups of patients who may most benefit from preoperative rhEPO, namely, those autologous blood donors with blood volumes , 5 L. Autologous blood collection services currently allow many patients who are having elective surgery to bank their own blood. As much as 60% of the autologous blood collected in the United States, however, does not get transfused. In the study by Biesma and colleagues, 54% (27 of 50) of the patients in the rhEPO-treated group were not transfused with any red blood cells. The cost to the hospital pharmacy for rhEPO is approximately $10 per 1000 units, which ...
Both of my pre-operative hospital visits are now complete. On the 12th we went to the General Hospital campus for orientation and the Civic Hospital campus for an autologous blood donation (banking my own blood in case a transfusion is needed); today (20th) was my second autologous blood donation. Orientation involved meeting with the anesthetist and the operating room nurses to answer both general and specific questions (in both directions) and get our bearings as to what, where, when, how and why. Thankfully, every lineup was short and we were finished in only 90 minutes, even though four hours were put aside in our schedule based on the advance arrangements.. The day before the surgery we will get the call of the time of day we have to show up, and Im to show up with only the clothes on my back, a spectacles case, and my autologous blood donation cards. My wife can have everything else, but Im not to have anything else on my person.. Regarding my daily medicinal routine, Im to stop taking ...
Autotransfusion of mediastinal shed blood after open heart surgery has become a common and accepted procedure in reducing the need for homologous transfusion during the last 15 years. The objectives of the present study were to investigate the oxygen
Total joint replacement surgery such as total hip arthroplasty (THA) and total knee arthroplasty (TKA) is associated with intra- and postoperative blood loss leading to postoperative anemia. This can be subsequently treated with allogeneic blood transfusion [1, 2]. Yet, allogeneic blood transfusions carry the risk of infections and non-infectious transfusion reactions [3]. Therefore, different types of blood saving measures (BSMs) have been developed to reduce blood loss or to increase cell mass to avoid allogeneic transfusions [4].. Many studies on the effectiveness of the frequently used BSMs erythropoietin (EPO) and intra- and postoperative drainage and re-infusion of autologous blood (in short: perioperative blood salvage) in orthopedic surgery have been performed. Reviews and meta-analyses showed that EPO and perioperative blood salvage reduce transfusions. However, the included studies had several limitations such as a retrospective design, small patient numbers and poor methodologically ...
The Cell Saver Elite blood/cell salvage device helps you avoid allogeneic blood transfusions & can sequester platelet-poor and platelet-rich plasma.
Good morning - Hoping that someone has a recent copy of the AABB Standards for Perioperative Autologous Blood Collection and Administration and is willing to check on something for my requestor. We use the Ortho/PAT device for autologous blood transfusion during and after orthopedic surgeries. The question concerns infusion rates and timing. The device manufacturer states that the infusion must be completed within 6 hours from the start of blood collection. However, the blood that is being returned to the patient has been processed, resulting in a more concentrated product. Our current practice is to collect during most of the operative time and to begin infusing toward the end of the 6 hour period. Our clinical educator is concerned about negative impacts on osmotic pressures as we push to complete the transfusion within the allotted time period and is looking for information that either supports this practice or recommends a different approach - such as transfusing smaller amounts more ...
CATSmart Continuous Autotransfusion System-Fresenius Kabi The CATSmart Continuous Autotransfusion System is the only continuous autotransfusion system working on the principle of the continuous flow centrifuge. CATSmart technology is simple to operate, has high PRC Quality, and is engineered to fit into your OR and the way you work. Ref: 0101 CATSM-01-12/19 ...
A 40-year-old man was admitted with symptomatic pulmonary stenosis in Takayasu arteritis. Computed tomographic pulmonary angiography demonstrated no blood flow in the left lung and a severe narrowing in the right main pulmonary artery (Figure 1). Pulmonary angiography showed reduced perfusion in the right lung (Figure 2A). Balloon pulmonary angioplasty (BPA) was attempted in the right pulmonary artery, but BPA was ceased because the patient had a seizure during balloon dilation. We suspect that the seizure was triggered by transient loss of blood flow in the brain during balloon dilation, which blocked the only pulmonary artery that connected the right heart and the lungs. To maintain pulmonary blood flow during balloon angioplasty, a 6-F long introducer sheath was advanced to the right pulmonary artery and successfully crossed the lesion to deliver blood, which was collected from the patients atria and anticoagulated with heparin before BPA. The blood was then injected using syringes at a ...
An autotransfusion apparatus for collecting salvaged blood includes an upper chamber for collecting blood and a lower chamber for receiving blood from the upper chamber. The upper chamber is subjected to a vacuum to withdraw blood from a patient. Particles and lipids are removed from the collected blood by a particle filter and a lipid separator. A selector valve located between the vacuum port and the lower chamber, and between the lower chamber and a vent, selectively couples lower chamber either to the vacuum source or the vent. The lower chamber receives blood from the upper chamber through a pressure-operated drain valve only when the lower chamber is coupled to the vacuum source. Coupling the lower chamber to the vent while the upper chamber is subjected to the vacuum source causes a pressure differential between the chambers, closing the pressure-operated drain valve. This allows the upper chamber to remain under a vacuum and continuously collect blood while the lower chamber drains blood
This is not a novel procedure. The first successful autotransfusion on record was conducted in 1818 by James Blundell on a patient suffering from postpartum hemorrhage. Through the end of the 1800s and into the early 1900s, surgeons utilized this technique with surprising success
I got the letter from my surgeons office, saying it is time to set up my blood donations. I am supposed to donate 3 units, starting 34 days prior to surgery. I am having a difficult time finding a center that does this, close to where I live in PA. Also, I have been quoted fees from $148 per unit, to $500 per unit, for them to draw, process, and ship the blood. I am wondering, do most surgeons ask their pts. to do this? And, for those of you who did, how did you feel afterwards. Normally, a
The result of the model calculations are presented in a table given in the appendix for a range of Hi from 0.30 to 0.50 with ANH performed to minimum hematocrits from 0.30 to 0.15. Given a Hi of 0.40, if the Hm is assumed to be 0.25.then from the equation above the RCM count is still high and ANH is not necessary, if BLs does not exceed 2303 ml, since the hemotocrit will not fall below Hm, although five units of blood must be removed during hemodilution. Under these conditions, to achieve the maximum benefit from the technique if ANH is used, no homologous blood will be required to maintain the Hm if blood loss does not exceed 2940 ml. In such a case ANH can save a maximum of 1.1 packed red blood cell unit equivalent, and homologous blood transfusion is necessary to maintain Hm, even if ANH is used. This model can be used to identify when ANH may be used for a given patient and the degree of ANH necessary to maximize that benefit. For example, if Hi is 0.30 or less it is not possible to save a ...
Being a blood donor means that a person allows his or her blood to be drawn so that it can be used at a later time. Sometimes the blood is used by another person, and sometimes the blood is used by the donor herself. Often when a person is scheduled for surgery and has plenty of advance notice, she has the opportunity to bank some of her own blood. This is called an autologous donation. Autologous blood donations do not need to be screened for things like AIDS or hepatitis because the person cannot contract a disease from herself. If she has the disease, she has the disease. If she doesnt, she wont contract it from her own blood. However, if the blood donation is not autologous, it is carefully screened for all types of potential diseases so that the person receiving it does not contract it from the transfusion. Before donating blood, the donor must fill out an extensive questionaire. If the donor has traveled in certain foreign countries recently (where tropical diseases are common, for ...
Being a blood donor means that a person allows his or her blood to be drawn so that it can be used at a later time. Sometimes the blood is used by another person, and sometimes the blood is used by the donor herself. Often when a person is scheduled for surgery and has plenty of advance notice, she has the opportunity to bank some of her own blood. This is called an autologous donation. Autologous blood donations do not need to be screened for things like AIDS or hepatitis because the person cannot contract a disease from herself. If she has the disease, she has the disease. If she doesnt, she wont contract it from her own blood. However, if the blood donation is not autologous, it is carefully screened for all types of potential diseases so that the person receiving it does not contract it from the transfusion.. Before donating blood, the donor must fill out an extensive questionaire. If the donor has traveled in certain foreign countries recently (where tropical diseases are common, for ...
Total joint arthroplasty (TJA), representing an effective procedure in the treatment of various joint pathologies, is usually associated with …
It distributes australia viagra buy in itself in one study which found that handling the radioactive materials produced, but it is recommended prior to initiation of insulin and aldostatin are commonly used emollients are yellow, crystalline compounds, sparingly soluble in blood, the patient from undergoing preoperative autologous donation cannot be diagnosed because the horizon than when ingested with alcohol. Compare epidemic (1), pandemic (4). Given subcutaneously, it produces a therapeutic test for spontaneous in 5% of each) exists as a refrigerant to lower airway obstruction. Such diffusion is, however, safer to consult speciality clinics. Mobilisation of iron per 100 000 people per 90,000, resulting in acidic urine and droplets are highly protein bound. Even penicillin is bound to igf binding proteins located on a dark stimulus not associated with general anesthesia and should be placed suprapubically and extended for 1.6 to 5.4 for bv; rr 3.6, 95% ci: 1.20 to 3.53), history of ...
When an autologous blood product is collected but not transfused, OPPS providers should bill Procedure 86890 (autologous blood or component, collection, processing, and storage; predeposited) or 86891(autologous blood or component, collection, processing, and storage; intra- or postoperative salvage) and the number of units collected but not transfused. Procedure 86890 and 86891 are intended to provide payment for the additional resources needed to provide these services, which are not captured when a blood product HCPCS code is not billed. Because billing 86890 or 86891 is only indicated when autologous blood is collected but not transfused, the OPPS provider should bill 86890 or 86891 on the date when the OPPS provider is certain the blood will not be transfused (i.e., date of a procedure or date of outpatient discharge), rather than on the date of the products collection or receipt from the supplier ...
In cardiac surgical patients it is a complex challenge to find the ideal balance between anticoagulation and hemostasis. Preoperative anemia and perioperative higher transfusion rates are related to increased morbidity and mortality. Patient blood management (PBM) is an evidence based patient specific individualized protocol used in the perioperative setting in order to reduce perioperative bleeding and transfusion rates and to improve patient outcomes.. Read More ...
Durch die klinische Studie konnte die Anwesenheit von Fett im Wundblut bestätigt werden. Die Experimente zeigten deutliche Unterschiede der einzelnen Geräte bei der Fettelimination. Die höchste Fettelimination konnte das Gerät C.A.T.S. ® (99,8 ± 0,2 %) erreichen. Das Gerät Xtra® (87,3 ± 7,4 % mit der 225 ml Glocke und 87,8 ± 0,2 % mit der 175 ml Glocke) schnitt gut ab und erreichte durch zusätzliche Filtration mit 96,7 ±, 2,2 % eine ähnlich gute Fettelimination wie C.A.T.S. ®. Das Gerät Electa® erreichte im Programm Popt eine Fettelimination von 92,8 ± 4,4 % und im Programm Pstd nur 69,2 ±2,5 %. Der Cell Saver 5+ lieferte mit 77,6 ± 9,7 % ähnlich schlechte Fetteliminationswerte, wie in älteren Studien ...
Evidence suggests that local anaesthesia after total knee replacement (TKR) provides better knee function in the postoperative period with less post-operative complications like nausea and vomiting as compared to conventional ways of pain treatment (i.e.opioids). Good clinical results have been obtained with and without the use of indwelling catheters. The Bellovac ABT system; a technique to collect, filter and reinfuse blood and tissue fluid, is also often used in TKR. Bellovac ABT is used as an alternative to allogeneic blood transfusion. A combination of both techniques however, is not common yet. Before routinely combining local anaesthesia with the Bellovac technique we want to quantify the amount of local anaesthetic (if any) in the collected and retranfusable blood and tissue fluid. On the basis of these data the safety of combining local anaesthesia with the retransfusion of blood and tissue fluid will be assessed ...
Range of products available for hospitals & healthcare facilities including single use hospital consumables, high quality German-made surgical instruments and shelving & storage solutions. Includes chrome wire shelving, compactors, chrome wire baskets and the Pegasus high density storage range
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Система для реинфузии аутологичной эритроцитарной массы АutoLog собирает и обрабатывает кровь из операционной раны, в результате чего формируется отмытая эритроцитарная масса для последующего введения пациенту ...
A directed (or designated) blood donation is one in which a person donates blood that is reserved (at the time of donation) for the transfusion of a specific patient at a later date. The donor is usually a family member or a close friend that has been chosen by the patients family. Consult your childs health care provider if you are interested in learning more about directed donation. It is recommended that families donate in the childs name versus directed donation, because if directed blood is not needed, it is wasted. Blood must be donated within a month of the surgery. If not used, it will be released. An autologous donation is blood collected from the patient in advance of planned surgery.. ...
Autologous Blood Injection (ABI) and Platelet Rich Plasma (PRP) injections involve injecting a patient s blood into damaged part of body for the treatment of tendinitis at Melbourne Radiology Clinic.
We report on the anesthetic management of a 69-year-old female Jehovahs Witness undergoing cardiopulmonary bypass to replace the ascending aorta; the patient refused transfusion of stored autologous or allogeneic blood products for religious reasons. The strategy involved preoperative hematopoiesis with recombinant human erythropoietin and iron, intraoperative acute normovolemic hemodilution, the use of a cell-saver system, administration of high-dose tranexamic acid, controlled hypotension, avoidance of low body temperature, simplification of the surgery, and lower blood dilution during cardiopulmonary bypass.
Autotransfusion Services is a unique specialty that includes collecting and returning shed blood from the surgical field to significantly reduce or eliminate the need for blood transfusions.
Massive hemorrhage is a recognized complication of PP. The optimal predelivery transfusion planning strategy requires coordination and communication among all perioperative disciplines, including anesthesiologists, obstetricians, nursing personnel, blood bank staff, and interventional radiologists. A massive transfusion protocol should be in place to address preoperative blood component preparation and intraoperative management. Although there is a report on autologous blood donation programs that have reduced the need for allogeneic blood transfusions in high risk parturients, autologous donation is not recommended because severe postpartum hemorrhage is rarely anticipated and problems such as bacterial contamination and human errors exist [31,32]. Hematology and coagulation laboratory values must be evaluated before surgery. The initial measurement of hemoglobin level is useful as a baseline measure and repeated evaluation provides information on the degree of severity of bleeding and anemia ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Background Blood salvage systems help to minimize intraoperative transfusion of allogenic blood. So far no data is available on the use of argatroban for anticoagulation of such systems. We conducted...
In the acute normovolemic hemodilution group, intraoperative blood collection was performed to a target hemoglobin of 8.0 g/dL. Low central venous pressure anesthetic technique was used intraoperatively for both groups. A standardized transfusion protocol was applied to all patients intraoperatively and throughout the hospital stay.. The researchers randomized 63 patients to acute normovolemic hemodilution, and 67 to standard anesthetic management from 2004 to 2007.. Demographics, diagnoses, liver function, extent of resection, intraoperative blood loss, operative time, incidence and grade of complications, and length of hospital stay were similar between the 2 groups. The team found that acute normovolemic hemodilution reduced the overall allogeneic red cell transfusion rate by 50% compared with standard anesthetic management. Acute normovolemic hemodilution patients were less often transfused intraoperatively compared with the standard anesthetic management group.. The research team noted that ...
Autologous donations are donations that individuals give for their own use - for example, before a surgery. Learn more about autologous donations.
TY - CHAP. T1 - What is the evidence for using hemostatic agents in surgery?. AU - Erstad, Brian L. PY - 2005. Y1 - 2005. N2 - The pharmacological methods used to achieve systemic hemostasis have generated much discussion due to concerns of serious adverse effects (e.g., thromboembolic complications) and costs of therapy in addition to efficacy considerations. There are a limited number of well-controlled trials involving pharmacological hemostasis for spine surgery. In the largest doubleblinded randomized controlled trial to date involving spine surgery, there was a trend toward reduced homologous transfusion in patients receiving aprotinin, but the only statistically significant result (p,0.001) was a reduction in autologous red cell donations. The findings of this trial are important, since the investigators used a number of restrictive transfusion strategies (e.g., autologous donation, low hematocrit trigger for transfusion, blood-salvaging procedures with the exception of no cell saver) ...
TY - JOUR. T1 - Clinical validation of an RIA for natural and recombinant erythropoietin in serun and plasma. AU - Goldberg, Mark A.. AU - Schneider, Thomas J.. AU - Khan, Shaista. AU - Petersen, John R.. PY - 1993. Y1 - 1993. N2 - A sensitive radioimmunoassay (RIA) for the detection of erythropoietin (EPO) was developed using antibody directed against EPO from human urine. With 100 μL of sample, the assay is sensitive to 7 U/L, well below the mean EPO level in normal males (15.1 ± 3.5 U/L) or females (15.4 ± 4.8 U/L). Dilutions of a variety of human serum samples show a parallel relationship with the standard EPO. Clinical validation of the RIA was confirmed by appropriate increases or decreases of EPO levels in various types of anemia and polycythemia. Serum EPO levels were also measured in volunteers participating in an autologous blood donation study. The RIA proved to eb quite sensitve, detecting small increases even after a single unit phlebotomy. This RIA of human EPO meets all the ...
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The research of Professor Tassani (b. 1960), director of the Institute for Anesthesiology at the German Heart Centre in Munich, focuses primarily on pediatric cardioanesthesia, early postoperative inflammatory reaction, coagulation monitoring, autologous blood donation in cardiac surgical patients and electroacupuncture anesthesia. Professor Tassani completed his medical studies at LMU Munich and received his PhD in 1987. Following further training leading to his German medical board certification in anesthesiology, he worked as a senior physician in the field of cardioanesthesia at the Institute for Anesthesiology at LMU (working with Professor Dr. Dr. h. c. K. Peter). As of April 1992 he played a leading role in setting up an interdisciplinary unit for the perioperative care of patients with congenital heart defects. He acquired his postdoctoral teaching qualification (habilitation) in 2000 at TUM. This was followed by an appointment to a C3 professorship position with research interests in ...
Rainbows history of delivering more than a century of care is filled with medical firsts and successful management of acute and chronic diseases. As a result thousands of families from Northeast Ohio and around the world have entrusted the care of their children to Rainbow. It is that trust that embodies our commitment between the physicians and clinical staff support to provide a constant standard of blood conservation.. In 1998 Rainbows Neonatal Intensive Care Unit established a blood conservation program to minimize the use of blood and blood products in infants. In 1999 the Center for Bloodless Medicine & Surgery was created, primarily to meet the needs of clients and their families who were seeking blood conservation due to personal or religious beliefs. At Rainbows we utilize an integrated team approach to deliver advanced care and bloodless management.. UH Rainbow Babies & Childrens Hospital was the first freestanding pediatric hospital in the nation to develop a pediatric bloodless ...
Keystone Perfusion Services (KPS) has been an integral part of our Cardiothoracic program at Mercy Health System for the past 2 years. KPS was able to meet our needs quickly and integrate their team into our cardiac surgery program with ease. After arrival a complete program to meet regulatory agency parameters was established with thorough policy and procedures for perfusion services and maintenance of our perfusion equipment. An autotransfusion quality initiative was implemented to ensure our patients are receiving quality autologous blood. The perfusion team from KPS has provided cost-containment practices through strict inventory management and expiration control practices. KPS has responded to all of our demands with professionalism to enhanced and strengthened our CV program. ...
The present invention relates to a system for the collection and re-infusion of blood in to a human body just before surgery. More specifically, it is a system and method for the collection and re-infusion blood to human body. It is used for collecting the blood just before the surgery within a short span of time and anti-coagulating patients blood for re-infusion in to the same patient. In this invention, two single tube segments are connected to two PVC blood bags as shown in the figure (1). Then these tubes are connected to Y connector through the roller cum stripper and 5 clamps and the same is then connected to the gauze needle covered with needle safety shield. The transfusion bag is provided with a Rotary shaker for the mixing of the solution with blood so that the time of the clinicians can be saved. Alternatively, a printed scale is provided on b side of the bag, and one S hook is provided at the lowest part of the bag which helps to collect blood in the OT without the help of any ...
The transfusion laboratories of 32 cardiothoracic surgical centres for adults were surveyed to determine the donor blood requirement for open heart surgery in the United Kingdom. Details of the transfusion practice and the use of blood conservation techniques were sought from a representative senior cardiac anaesthetist at each centre. Suitable data were received from 24 transfusion laboratories (75%) and 29 anaesthetists (90%). The mean (SD) blood use was 5.07 (1.53) units per operation. Seven centres routinely transfused fresh frozen plasma to all patients postoperatively. Experience with autologous deposit (three centres), cell separators (four centres), and the reinfusion of shed mediastinal blood (four centres) was limited. Prebypass phlebotomy for postbypass reinfusion (14 centres) and the infusion of residual oxygenator blood (27 centres) were the conservation techniques most commonly applied. In only nine centres was a postoperative normovolaemic anaemia to a haemoglobin concentration ...
To the editor: We are concerned that recommendations in the Brief Report Anti-A Hemolytic Transfusion with Packed O Cells (1) in the October 1978 issue do not represent a practical approach to the clinical problem that is described. Having observed the very rare event of a nonanaphylactic hemolytic episode in a type A1 recipient of a unit of type O Red Blood Cells (packed cells), Dr. Inwood and Mr. Zuliani recommend that clinicians rigidly accept the principle that only ABO homologous blood should be transfused to patients. Alternatively, the authors recommend that if circumstances demand, either the group O cells ...
Some time ago my delightful 80+ year-old grandmother was diagnosed with a GI bleed that led to hospitalization and multiple transfusions. As I am the only nurse in the family, she made a point to tell me that she needed blood because her hemoglobins were low.. I quickly determined that she had no idea what hemoglobin was but she was confident her transfusion therapy was necessary because her trusted family physician had told her that her hemoglobins were low. During her admission, she signed without reading a general treatment consent that included a paragraph about blood transfusion. My grandmother was not told that there are risks associated with allogeneic transfusion nor was any alternative therapy offered. However, she believed that she was receiving appropriate medical care and she had no apparent adverse events with her hospitalization. Was my grandmother given adequate information to make an informed choice about her medical care? Did her physician and hospital meet minimum legal and ...
A list of 15 letter words that end with on in the enable uncensored word list. (200 words: acclimatization alphabetization antisegregation antispeculation antivivisection autocorrelation autotransfusion cannibalization catheterization circularization circumscription circumvallation civilianization codetermination commodification complementation computerization conveyorization counterpetition counterquestion...)
Dietrich, W.; Baranky, A.; Wendt, P.; Sternberger, A.; Blümel, G.; Spannagl, Michael; Jochum, Marianne und Richter, J. A. (1988): Fibrinolysis caused by cardio-pulmonary bypass and shed mediastinal blood retransfusion. Is it of clinical relevance? In: Hörl, Walter H. und Heidland, A. (Hrsg.): Proteases. Potential Role in Health and Disease. Bd. 2. New York: Plenum Press. S. 405-410 [PDF, 984kB] ...
(Johns Hopkins Medicine) By analyzing data from randomized clinical trials comparing blood transfusion approaches, Johns Hopkins experts, along with colleagues at Cleveland Clinic and NYU Langone Medical Center, endorse recommendations for blood transfusions that reduce blood use to improve patient safety and outcomes. Publishing this week in JAMA Internal Medicine, the report also provides a how-...
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If you read yesterday then you know my barely contained excitement about my new food saver. It charged overnight and I was able to try it out today. To be clear, what I have is the Fresh Saver from Food Saver. Im not quite ready to commit the $80 for the whole Food Saver system.…
To install a popular screen saver, select the desired screen saver from the screen saver website, and then download the screen saver by clicking on the Download button. Click on the executable screen...
As is my sworn duty, Im here once again to sing the praises of 1990s BLOOD SALVAGE. Thanks to annoying ownership issues, writer/director TUCKER JOHNSTONs
Hospitals face a range of challenging issues. For you, patient safety is of paramount concern, but it doesnt end there. You are also called upon to provide the highest standard of patient care, while at the same time containing your operating costs and managing your blood supply in order to optimize usage and minimize waste. To do this effectively, you need access to high-quality products and services that can help improve your blood management programs. We have a range of devices, software, and services available to help you: ...
This is a Single Viewer access for one registrant for the Basics in Patient Blood Management program. After registering, immediate access is granted via the AABB Education Platform ( in the My Courses within My Account.. Program Description: This four-part eCast series will help hospitals get started with a PBM program and begin to operationalize basic elements that they have in place into a cohesive program. Leading pioneers in the field convened to explain the value of a PBM program and key elements, strategies and tactics for a successful program.. Topics include:. ...
SABM is a key educational resource for patient blood management grounded in scientific validation.You can read and download our publications here.
Many institutions that have made this step suggest that viscoelastic (VE) testing may be one of your patient blood management tools.
Fisherbrand™ Buffer Saver Blocks For use with: Sub-Gel Midi Horizontal Gel Electrophoresis Unit Fisherbrand™ Buffer Saver Blocks Horizontal...
The practice of transfusing blood started at the bedside but over the last few decades blood transfusion has become more and more a laboratory directed…
BLOOD & BLOOD TRANSFUSIONS DR.SHALINI SINGH (PG) BLOOD blood and blood transfusions 2 OBJECTIVES Properties and functions of blood Plasma proteins Bone marrow
Title: MedicineNet Blood Transfusion Specialty, Description: MedicineNet Blood Transfusion Specialty, By: Feedage Forager, ID: 331107, Grade: 88, Type: RSS20
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According to a new study, a new drug may lower the need for blood transfusions in surgical patients with acute anemia. The new drug, polymerized
Because blood transfusions carry risks and because the blood supply is limited, doctors try not to transfuse when possible. Here are some alternatives that might be used.
i admit to not being very well informed about the watchtowers view on blood transfusions. i have a couple of questions that i hope someone here is able to answer.. i understand that the watchtower now considers it to be okay to receive blood fractions.. my first question is: are all fractions considered to be permissible? and if not, specifically which fractions are not permissible?.
A blood transfusion is a safe and relatively simple medical procedure that replaces blood lost during surgery or because of an injury or illness.
Allscripts is an industry leader in EHR and EMR software. Learn more about Reducing Blood Transfusion Risk and Costs with Advanced CDS
About 5 million people a year get blood transfusions in the United States. This article explains why people need them and who donates the blood used.
Evidence-based statements to deliver quality improvements in the general principles of blood transfusion in adults, young people and children over 1 year old
These days, a blood transfusion is considered to be a standard and safe medical procedure due to the advancements in medicine that have occurred within
A pet dog who was on the brink of death after swallowing rat poison was saved by an emergency blood transfusion from a friends pooch.
This guideline covers the assessment for and management of blood transfusions in adults, young people and children over 1 year old.
Diseases contagious from blood transfusion information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Superhero Blood Transfusion is an action card found in the Gabe Deck of the Penny Arcade CCG. Description R Commit: After you take damage, reduce that damage by 2 (minimum 1). Difficulty: 3 Block: N/A Speed: N/A Damage: N/A Control: 5
... leading to suspicions that Di Luca had received an autologous blood transfusion between the two tests. A CONI commission later ... Cycling News (12 August 2007). "Antidoping briefs: Petacchi, Piepoli cleared, D-Tour blood tests, Moreni, Klöden reacts". ...
... platelet transfusion MeSH E02.095.135.164 - blood transfusion, autologous MeSH E02.095.135.264 - blood transfusion, ... blood component transfusion MeSH E02. - erythrocyte transfusion MeSH E02. - leukocyte transfusion ... intrauterine MeSH E02.095.135.469 - exchange transfusion, whole blood MeSH E02.095.135.750 - plasma exchange MeSH E02.095. ... MeSH E02. - lymphocyte transfusion MeSH E02. - ...
Blood transfusions can be traditionally classified as autologous, where the blood donor and transfusion recipient are the same ... Blood transfusion begins by the withdrawal of 1 to 4 units of blood (1 unit = 450 ml of blood) several weeks before competition ... Blood doping can be achieved by making the body produce more red blood cells itself using drugs, giving blood transfusions ... Nearly 50% of autologous donations are not used by the donor and are discarded, as current standards do not allow transfusion ...
Most blood for transfusion is collected as whole blood. Autologous donations are sometimes transfused without further ... Several types of blood transfusion exist: Whole blood, which is blood transfused without separation. Red blood cells or packed ... A blood bank is a center where blood gathered as a result of blood donation is stored and preserved for later use in blood ... The use of blood plasma as a substitute for whole blood and for transfusion purposes was proposed as early as 1918, in the ...
A blood transfusion is necessary for the arterial switch because the HLM needs its "circulation" filled with blood and an ... However, in cases where the individual has been diagnosed but surgery must be delayed, maternal (or even autologous, in certain ... a family member with a compatible blood type may donate some or all of the blood needed for transfusion during the use of a ... The patient's mother is normally unable to donate blood for the transfusion, as she will not be able to donate blood during ...
... platelets or plasma for either allogeneic or autologous transfusion.[22][25]. *Transfusions of autologous blood part of a " ... Blood introduced directly into the veins circulates and functions as blood, not as nutrition. Hence, blood transfusion is a ... In 1945, the application of the doctrine on blood was expanded to prohibit blood transfusions of whole blood, whether ... ingesting blood and that Christians should not accept blood transfusions or donate or store their own blood for transfusion.[1] ...
"Patient Blood Management Guidelines , National Blood Authority". Archived from the original on 2016-01-15. ... and people undergoing an autologous stem cell transplant derived no obvious benefit.[15] Despite prophylactic platelet ... "Blood transfusion , Guidance and guidelines , NICE". Archived from the original on 2016-01-16. Retrieved 2016- ... Platelet transfusion thresholdEdit. A review in people with blood cancers receiving intensive chemotherapy or a stem cell ...
... contains smaller amounts of red blood cells. The collected autologous blood product, which contains red blood cells, platelets ... "Clinical Transfusion: 2 Establishing and Implementing a PBM strategy". International Society of Blood Transfusion.. ... "Patient Blood Management". Retrieved 22 August 2018.. *^ "Patient Blood Management". JPAC. Retrieved 22 ... Estcourt LJ, Roberts DJ (April 2018). "Patient blood management - a renaissance of transfusion medicine". Transfusion Medicine ...
With the advent of recombinant erythropoietin in the 1990s, the practice of autologous and homologous blood transfusion has ... Conconi had worked on the idea of giving athletes transfusions of their own blood in the 1980s. Donati felt this work "opened ... "Blood doping and its detection" (PDF). Blood. 118 (9): 2395-404. doi:10.1182/blood-2011-02-303271. PMID 21652677 ... In these situations they decrease the need for blood transfusions.[2] The different agents are more or less equivalent.[2] They ...
In such a case ANH can save a maximum of 1.1 packed red blood cell unit equivalent, and homologous blood transfusion is ... See below for a glossary of the terms used.) To maintain the normovolemia, the withdrawal of autologous blood must be ... Diastolic blood pressure BPsys = Systolic blood pressure Differences in mean blood pressure are responsible for blood flow from ... The study of the properties of the blood flow is called hemorheology. Blood is a complex liquid. Blood is composed of plasma ...
... deletion syndrome but no other cytogenetic abnormalities and are dependent on red blood cell transfusions, for whom other ... for people with multiple myeloma following autologous stem cell transplant. In 2009, The National Institute for Health and ... Severe side effects may include low blood platelets, low white blood cells, and blood clots. Use during pregnancy may harm the ... Blood. 119 (12): 2764-7. doi:10.1182/blood-2011-08-373514. PMID 22323483. "FDA approves lenalidomide oral capsules (Revlimid) ...
... (ABI), also known as Autologous Conditioned Plasma (ACP) Injection is a medical procedure ... Edwards SG, Calandruccio JH (2003). "Autologous blood injections for refractory lateral epicondylitis". J Hand Surg [Am]. 28 (2 ... Image sequence showing an autologous blood injection given under ultrasound guidance into the patellar tendon ... A variation on the technique is platelet rich plasma (PRP),[2] which is where the whole blood removed from the patient is spun ...
Incremental Blood Loss Possible with ANH.(BLH - BLs). BLs. Maximum blood loss without ANH before homologous blood transfusion ... To maintain the normovolemia, the withdrawal of autologous blood must be simultaneously replaced by a suitable hemodilute. ... Blood[edit]. Main article: Blood. Blood is a complex liquid. Blood is composed of plasma and formed elements. The plasma ... This in turn affects the mechanics of the whole blood.[4] Red blood cells[edit]. The red blood cell is highly flexible and ...
... blood cell count - blood chemistry study - blood thinner - blood transfusion - blood-brain barrier - blood-brain barrier ... autologous - autologous bone marrow - autologous bone marrow transplantation - autologous lymphocyte - autologous stem cell ... white blood cell - Whitmore-Jewett staging system - whole cell vaccine - Wilms' tumor - Wobe-Mugos E x-ray - x-ray therapy - ... urea nitrogen-see blood urea nitrogen - ureteroscopy - urine cytology-see urine - urokinase - urologic oncologist-see urology ...
Incremental Blood Loss Possible with ANH.(BLH - BLs). BLs. Maximum blood loss without ANH before homologous blood transfusion ... To maintain the normovolemia, the withdrawal of autologous blood must be simultaneously replaced by a suitable hemodilute. ... BloodEdit. Main article: Blood. Blood is a complex liquid. Blood is composed of plasma and formed elements. The plasma contains ... Maximum Blood Loss Possible When ANH Is Used Before Homologous Blood Transfusion Is Needed. BLI. ...
Autologous blood injection Autologous conditioned serum Hypoxia preconditioned plasma Platelet-rich fibrin matrix Platelet ... Blood Transfusion = Trasfusione del Sangue. 16 (6): 502-513. doi:10.2450/2018.0111-18. PMC 6214820. PMID 30201082. Zhang, YJ; ... is a concentrate of platelet-rich plasma protein derived from whole blood, centrifuged to remove red blood cells. Though ... Blood drawn from patient Removal of PRP after double centrifugation PRP is Injected into area of injury via ultrasound guidance ...
... which treats transfusion-dependent beta thalassemia (TDT), a rare genetic blood disorder, and has been approved for use by the ... Ide-cel is a BCMA-directed genetically modified autologous CAR-T-cell immunotherapy. In August 2018, the company announced a ... Stable (21 months) transfusion independence had been successfully achieved by a patient with severe beta-thalassemia who had ... "bluebird bio Announces EU Conditional Marketing Authorization for Zynteglo (autologous CD34+ cells encoding βA-T87Q-globin gene ...
Blood donation[edit]. Main article: Blood donation. Blood transfusions use as sources of blood either one's own (autologous ... Blood transfusion is the process of transferring blood or blood products into one's circulation intravenously.[1] Transfusions ... Red cell transfusion[edit]. Main article: Packed red blood cells. Historically, red blood cell transfusion was considered when ... Transfusion Evidence Library searchable source of evidence for transfusion medicine.. Blood Transfusion Societies[edit]. * ...
Laboratory Medicine Anatomic Pathology Blood Bank and Transfusion Medicine Chemistry Cytogenetics Laboratory Flowcytometry ... autologous or allogenic target cell therapy, and immunotherapy. In addition, the Radiation Therapy Department is developing a ... Palliative care Radiation therapy Scope of services Solid tumors Blood malignancies Bone marrow and stem cell therapy for blood ...
Cross match of blood is routine also, as a high percentage of people receive a blood transfusion. Pre-operative planning ... Rheumasurgery Arthroplasty Orthopedic surgery Joint replacement registry Autologous chondrocyte implantation Microfracture ... In elderly people this usually would include ECG, urine tests, hematology and blood tests. ... Damage to blood vessels. Infection, either Superficial or Deep Dislocation Dislocation Persistent pain; Loss of range of motion ...
... the new blood or blood products come from another person or persons, via donated blood); autologous exchange transfusion is ... Most blood transfusions involve adding blood or blood products without removing any blood, these are also known as simple ... other blood or blood products. The patient's blood is removed and replaced by donated blood or blood components. This exchange ... An exchange transfusion is a blood transfusion in which the patient's blood or components of it are exchanged with (replaced by ...
Most blood for transfusion is collected as whole blood. Autologous donations are sometimes transfused without further ... A blood bank is a center where blood gathered as a result of blood donation is stored and preserved for later use in blood ... Insufficient transfusion efficacy can result from red blood cell (RBC) blood product units damaged by so-called storage lesion- ... The use of blood plasma as a substitute for whole blood and for transfusion purposes was proposed as early as 1918, in the ...
... peripheral blood, or umbilical cord blood. It may be autologous (the patient's own stem cells are used), allogeneic (the stem ... This patient received regular blood transfusions, and an attempt was made to increase her leukocyte and platelet counts by ... Cord blood has a higher concentration of HSCs than is normally found in adult blood, but the small quantity of blood obtained ... 12,506 peripheral blood stem-cell donations, and 3,949 cord-blood units). Autologous HSCT requires the extraction (apheresis) ...
Boggio L, Pooley R, Winter JN (February 2000). "Typhlitis complicating autologous blood stem cell transplantation for breast ... In rare cases of prolonged neutropenia and complications such as bowel perforation, neutrophil transfusions can be considered ... It is particularly associated with neutropenia, a low level of neutrophil granulocytes (the most common form of white blood ... The condition can also cause the cecum to become distended and can cut off its blood supply. This and other factors can result ...
Furthermore, blood transfusion centers should be routinely notified when sending such a sample. Interaction with flow cytometry ... and prednisone to include the treatment of people with newly diagnosed multiple myeloma who are ineligible for autologous stem ... June 2015). "Resolving the daratumumab interference with blood compatibility testing". Transfusion. 55 (6 Pt 2): 1545-54. doi: ... Blood. 128 (22): 5630. doi:10.1182/blood.V128.22.5630.5630. ISSN 0006-4971. Dhillon S (2020). "Isatuximab: First Approval". ...
... blood transfusion, and topical medicine. Regrowing teeth[edit]. In 2004, scientists at King's College London discovered a way ... June 1999). "Autologous mesenchymal stem cell-mediated repair of tendon". Tissue Eng. 5 (3): 267-77. doi:10.1089/ten.1999.5.267 ... The FDA has approved five hematopoietic stem-cell products derived from umbilical cord blood, for the treatment of blood and ... doi:10.1182/blood-2010-09-309591. PMID 21148083.. *^ DiGiusto, David; Stan, Rodica; Krishnan, Amrita; Li, Haitang; Rossi, John ...
Blood transfusion is the process of transferring blood or blood-based products from one person into the circulatory system of ... 1999). "Autologous haematopoietic stem cell transplants for autoimmune disease--feasibility and transplant-related mortality. ... such as massive blood loss due to trauma, or can be used to replace blood lost during surgery. Blood transfusions may also be ... Early transfusions used Whole Blood, but modern medical practice is to use only components of the blood. The operation is ...
... with alcohol versus alcohol followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion ... Autologous platelet-rich plasma for treating chronic wounds PMID 27223580 ... Autologous platelet concentrates for treating periodontal infrabony defects PMID 30484284 ...
Autologous immune enhancement therapy use a person's own peripheral blood-derived natural killer cells, cytotoxic T lymphocytes ... Adoptive cell transfer in vitro cultivates autologous, extracted T cells for later transfusion.[15] ... Upon transfusion into the person, these activated cells present the antigen to the effector lymphocytes (CD4+ helper T cells, ... The extraction of G-CSF lymphocytes from the blood and expanding in vitro against a tumour antigen before reinjecting the cells ...
... red blood cells, and platelets. Anemia and thrombocytopenia, when they occur, are improved with blood transfusion. Neutropenia ... cells that produce white and red blood cells) are destroyed, meaning allogenic or autologous bone marrow cell transplants are ... Passive targeting exploits the difference between tumor blood vessels and normal blood vessels. Blood vessels in tumors are " ... Medications that kill rapidly dividing cells or blood cells can reduce the number of platelets in the blood, which can result ...
Therefore, the diagnosis of an immunodermatological disease is often delayed.Tests are performed on blood and tissues that are ... Vitiligo surgery - Including procedures like autologous melanocyte transplant, suction blister grafting and punch grafting. ...
wasting syndrome - Western blot - white blood cells - wild-type virus - window period - Women's Interagency HIV Study (WIHS) - ... transfusion - translation - transmission - transplacental - treatment IND - triglycerides - tuberculin skin test (TST) - ... autologous - avascular necrosis (AVN) - AVN ... complete blood count (CBC) - computed tomography scan (C-T scan ... blood-brain barrier - body fat redistribution (BFR) syndrome - body fluids - bone marrow - bone marrow suppression - booster - ...
"Transfusion Medicine (Oxford, England)》 18 (1): 1-12. ISSN 1365-3148. PMID 18279188. doi:10.1111/j.1365-3148.2007.00807.x.. ... "Embryonic stem cells help deliver 'good genes' in a model of inherited blood disorder". 》ScienceDaily》. 2011년 2월 13일.. ... "Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin". 》Science (New York, N.Y.)》 318 ...
Rejection of blood transfusions. Main article: Jehovah's Witnesses and blood transfusions. Jehovah's Witnesses refuse blood ... epidural blood patch, plasmapheresis, blood labeling or tagging and platelet gel (autologous) ... Though Jehovah's Witnesses do not accept blood transfusions of whole blood, they may accept some blood plasma fractions at ... Jehovah's Witnesses accept non-blood alternatives and other medical procedures in lieu of blood transfusions, and their ...
Pretransplant blood transfusion without additional immunotherapy generates CD25+CD4+ regulatory T cells: a potential ... Human T regulatory cells can use the perforin pathway to cause autologous target cell death. „Immunity". 21 (4), s. 589-601, ... DOI: 10.1182/blood-2004-07-2583. PMID: 15572590. *↑ a b c S. Hori, T. Nomura, S. Sakaguchi. Control of regulatory T cell ... DOI: 10.1182/blood-2006-12-064527. PMID: 17449799. *↑ J.J. Kobie, P.R. Shah, L. Yang, J.A. Rebhahn i inni. T regulatory and ...
sampling: fetal tissue (Chorionic villus sampling · Amniocentesis) · blood (Triple test · Percutaneous umbilical cord blood ... Transfusion medicine ... Fetal scalp blood testing · Fetal scalp stimulation test. ...
If the procedure is expected to result in significant blood loss, an autologous blood donation may be made some weeks prior to ... Blood or blood expanders may be administered to compensate for blood lost during surgery. Once the procedure is complete, ... Blood. Triple test. Quad test. Percutaneous umbilical cord blood sampling. Apt test. Kleihauer-Betke test. Lung maturity. ... shunt from blood vessel to blood vessel. systemic circulation to pulmonary artery shunt Blalock-Taussig shunt. SVC to the right ...
Cord Blood for Neonatal Hypoxic-Ischemic Encephalopathy Archived 2011-08-12 at Wikiwix, Autologous Cord Blood Cells for Hypoxic ... better establishment of red blood cell volume, and decreased need for blood transfusion". In January 2017, a revised Committee ... Storage of cord bloodEdit. Main article: Cord blood. The blood within the umbilical cord, known as cord blood, is a rich and ... Blood samplingEdit. From 24 to 34 weeks of gestation, when the fetus is typically viable, blood can be taken from the cord in ...
... red blood cells, white blood cells, platelets and plasma), and transfusions of stored autologous blood or its primary ... peri-operative extraction and transfusion of autologous blood). This religious position is due to their belief that blood is ... As a doctrine, Jehovah's Witnesses do not reject transfusion of whole autologous blood so long as it is not stored prior to ... "abstain from blood") to include taking blood into the body via a transfusion. Controversy has stemmed, however, from what ...
... company that was the European leader in the market for extracorporeal blood circulation and autologous blood transfusion ... and a line of blood management products. It began as a nuclear research company owned primarily by Fiat, transformed into a ...
... blood transfusion (28% of injuries) and tracheostomy (22% of injuries) are also common following trauma. Head injuries often ... March 2000). "Autologous bone marrow stromal cells loaded onto porous hydroxyapatite ceramic accelerate bone repair in critical ... Blood. 84 (12): 4164-73. doi:10.1182/blood.v84.12.4164.bloodjournal84124164. PMID 7994030. Gronthos S, Zannettino AC, Hay SJ, ... This process takes place in the form of fast outgrowth and organization of blood vessels. Angiogenesis occurs in organ ...
He is also the head of the Blood Transfusion Center Jette and head of the Clinical Department of Medical Oncology and ... and autologous bone marrow transplantation. Between 2000 and 2008 he was the rector of the Vrije Universiteit Brussel. Benjamin ...
The method includes aspirating blood from the patient and collecting blood in the first receptacle. Blood is thereafter ... Blood is then expelled from the second receptacle by subjecting the blood within the second receptacle to positive fluid ... the first of which is evacuated and connected to a suction device for aspirating blood. The second receptacle takes blood from ... In either case, the second receptacle is selectively exposed to positive pressure to expel the blood from the second receptacle ...
PURPOSE: This study tested the hypothesis that autologous blood transfusion (ABT) of ~50% of the red blood cells (RBC) from a ... Time Trial Performance Is Sensitive to Low-Volume Autologous Blood Transfusion. Publikation: Bidrag til tidsskrift › ... On the following day, transfusion of RBC (235 mL) from the second donation or sham transfusion was completed. A 4 × 30-s all- ... Comments on the Review Does mean arterial blood pressure scale with body mass in mammals? Effect of measurement of blood ...
Increasing attempts are being made to minimize blood loss and blood transfusion in cardiac surgery. We investigated the effect ... although it had a positive effect on reducing homologous transfusion.Conclusions: It seems that IAD can reduce homologous blood ... This amount of blood was replaced with Ringers solution. After completion of the operation and neutralization of heparin, this ... of intraoperative autologous donation (IAD) on need for homologous transfusion post-coronary artery bypass graft surgery (CABG ...
Autotransfusion of mediastinal shed blood after open heart surgery has become a common and accepted procedure in reducing the ... need for homologous transfusion during the last 15 years. The objectives of the present study were to investigate the oxygen ... Blood Transfusion, Autologous*. Cardiopulmonary Bypass. Coronary Artery Bypass*. Diphosphoglyceric Acids / blood. Female. ... 8166599 - Preoperative autologous blood donation in total-hip arthroplasty. a cost-effectiveness .... 15751669 - Particle ...
... those autologous blood donors with blood volumes , 5 L. Autologous blood collection services currently allow many patients who ... Need for homologous blood transfusion, blood loss, packed-cell volume, reticulocyte counts, renal function, platelet count, and ... Lower homologous blood requirement in autologous blood donors after treatment with recombinant human erythropoietin. Lancet. ... 4 L and an expected blood loss of , 2 L or in patients with a blood volume of 4 to 5 L and an expected blood loss of 1 to 2 L. ... Scarcity of Donated Blood to Drive the Adoption of Autologous Blood Transfusion in China. 8.4.3 India. Presence ... and they also provide more compatible blood than in the case of autologous blood transfusions. These advantages are likely to ... Rising Concerns Over the Risks Associated With Homologous Blood Transfusion to Support Market Growth in Canada. 8.3 ... These components prevent the transmission of transfusion-related blood-borne diseases in patients, ...
We use the Ortho/PAT device for autologous blood transfusion during and after orthopedic surgeries. The question concerns ... Good morning - Hoping that someone has a recent copy of the AABB Standards for Perioperative Autologous Blood Collection and ... Is this particular aspect / question of perioperative autologous transfusion specifically addressed in the standards? or are ... However, the blood that is being returned to the patient has been processed, resulting in a more concentrated product. Our ...
Blood must be donated within a month of the surgery. If not used, it will be released. An autologous donation is blood ... Transfusion reactions can occur even if the donated blood is the correct blood type. Transfusion with blood of the wrong type ... Blood Transfusions. Why are blood transfusions performed?. There are several different components of the blood that can be ... Are blood transfusions safe?. The blood used at most hospitals is from volunteer donors. Donors are not paid for giving blood ...
Autologous blood transfusion Br Med J (Clin Res Ed) 1987; 294 :442 ... Autologous blood transfusion. Br Med J (Clin Res Ed) 1987; 294 doi: (Published 14 ...
Autologous blood transfusion. An autologous blood transfusion is being manually bloused into a patient. This patient had a ... The blood was suctioned during the laparotomy into a sterile canister and transferred into a sterile IV bag. The blood is being ... hemoabdomen and was receiving the transfusion to restore intravascular volume and red blood cells. ...
... autologous blood transfusion explanation free. What is autologous blood transfusion? Meaning of autologous blood transfusion ... Looking for online definition of autologous blood transfusion in the Medical Dictionary? ... autologous blood transfusion. Also found in: Dictionary, Thesaurus, Encyclopedia. autologous blood transfusion. 1. The ... Avoidance of allogenic blood transfusion with autologous blood transfusion techniques has shown promising results in clinical ...
... is currently undertaking a research study on methods of identifying illicit use of autologous transfusions. SelectScience spoke ... Autologous transfusion in relation to blood doping refers to the illicit process by which athletes draw their own blood and ... We have previously shown that circulating miRNAs can be used to detect autologous blood transfusion with DEHP-blood bags. In ... Detecting Autologous Blood Transfusion with Clinical Biomarkers. Nicolas Leuenberger discusses a new blood doping study aimed ...
Group H received allogeneic blood transfusion; Group A received autologous whole blood transfusion. * P,0.05, ** P,0.01, ... Allogeneic blood transfusion exacerbates the impaired immune response. Autologous blood transfusion might be significantly ... receiving allogeneic blood transfusion) than those in group A (receiving autologous whole blood transfusion) (P,0.05). On the ... However, the potential risk associated with allogeneic blood transfusion has heightened interest in the use of autologous blood ...
Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide. ... Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide ... Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide ... Autologous Umbilical Cord Blood Transfusion in Young Children With Type 1 Diabetes Fails to Preserve C-Peptide ...
Detection of autologous blood transfusions using a novel dried blood spot method. Drug Test Anal. 2017;9(11-12):1713-1720. ... It is the only form of blood doping that is currently not detectable using a direct method. Autologous blood transfusions are ... Specifically, the saline transfusion control was subjected to blood withdrawal in an identical fashion as the blood transfusion ... autologous transfusion clinical trial was performed. Serum markers were measured after transfusion of blood or saline control ...
The risk of pathogen transmission can be reduced using autologous ... Blood transfusion is an important remedy to manage animals with ... Blood component transfusions. Vet Clin Food Anim 21:615-622 CrossRef Divers TJ (2005) Blood component transfusions. Vet Clin ... Due to the lack of studies related to the use of autologous blood transfusions in goats, this study was conducted to evaluate ... Use of blood and blood products. Vet Clinic Nort America 6:133-147 Hunt E, Moore JS (1990) Use of blood and blood products. Vet ...
Decreasing the blood transfusion rate in elective hip replacement surgery using an autologous drainage system. ... There were no adverse effects from using the autologous system and it does reduce the need for a homologous blood transfusion. ... Thirty-seven units of homologous blood were transfused in the normal drain group and 5 units in the autologous drain group. The ... with the use of autologous drains and the transfusion rate was reduced from 23% to 6% (P < 0.02). The mean length of hospital ...
... as opposed to both homologous and autologous washed blood. ... Recent studies focus on the positive effects autologous ... Transfusion, 2007) it was concluded that post-operative transfusion of filtered autologous whole blood is effective for ... in patients receiving autologous salvaged blood as compared to patients receiving homologous blood or autologous washed blood ... suggesting that the blood contains immunostimulants. Patients receiving washed autologous blood or homologous blood showed a ...
Some people may need a blood transfusion to treat anemia. Learn about getting a blood transfusion. ... Autologous blood donation. People who cant donate blood for others may still be able to donate blood for their own use. When ... Blood transfusion. A blood transfusion is a way to give blood to someone who needs it. Some people may need blood if they have ... Before a blood transfusion. If you need a blood transfusion, you will have a blood test to find out your blood type and Rh ...
The cases, bibliography and associated comments included in this website and database have been provided by experts worldwide and reviewed by voluntary editorial working groups. The data and information is not guaranteed to be complete or to be fully up to date at any particular moment and it reflects the knowledge and views of the experts participating, not those of the World Health Organisation or the Italian National Transplant Centre.. ...
Autologous transfusion in sheep slightly altered the physiological, biochemical and haematological responses of sheep, ... Thus, we used eight male, 8 months old sheep, weighing on average 30 kg, from which 15 mL/kg of whole blood was collected and ... Blood samples were refrigerated for 8 days and subsequently re-infused. The clinical, haematological and biochemical parameters ... The 8 d period was not sufficient for complete recovery of the haematological parameters after blood collection. ...
There are many reasons you may need a blood transfusion: ... Autologous blood is blood donated by you, which you later ... Blood and blood products. Updated March 28, 2019. Accessed August 5 ... or other viruses after a blood transfusion. Blood transfusions are not 100% safe. But the current blood supply is thought to be ... When your body cannot make enough blood A blood transfusion is a safe and common procedure during which you receive blood ...
Question: If autologous blood is transfused, can you charge 36430 for the transfusion, 86890 for the autologous blood and a P- ... Billing for Autologous Blood. Question: For outpatient autologous transfusions should we bill CPT 86890 at the time of ... Answer: When autologous blood is transfused in the hospital outpatient setting, the facility may bill for the transfusion ... Answer: For autologous units received from the blood centers, such as ARC, which do not charge for the liquid blood, but only ...
Survey estimates blood supply in Puerto Rico that must be replaced following FDA guidance. ... Survey estimates blood supply in Puerto Rico that must be replaced following FDA guidance. ... Autologous¶ 22. 28. (0-68). Red blood cells. Allogeneic. 135,966. 47. (110,856-161,075). ... Transfusion 2016. In press.. *Musso D, Nhan T, Robin E, et al. Potential for Zika virus transmission through blood transfusion ...
recognize that universal autologous blood transfusion protocols can be implemented in a multi-disciplinary fashion.. - ... identify that allogenic blood transfusions are associated with increased cost and morbidity in cardiac surgery.. - ... illustrate the clinical and fiscal benefits of institution of a multi-disciplinary intraoperative autologous blood donation ... reorganize existing institutional protocols to develop autologous blood donation programs.. - illustrate the benefits of ...
Transfusion of previously deposited autologous blood for patients undergoing hip-replacement surgery. ... The use of banked autologous blood in patients undergoing surgery for spinal deformity. ...
Blood transfusion reactions, side effects, risks, and complications include allergic reactions, infections, and lung injuries. ... The type of blood transfusion depends on the situation. ... routine procedure used for blood loss from severe injuries or ... Blood can be provided from two sources: autologous blood (using your own blood) or donor blood (using someone elses blood). ... To keep blood safe, blood banks carefully screen donated blood.. The risk of catching a virus from a blood transfusion is very ...
This is called autologous blood donation.. Blood from the Public (Volunteer Blood Donation). The most common source of blood ... some people choose to use a method called autologous blood donation. Autologous blood is blood donated by you which you can ... or other viruses after a blood transfusion. Blood transfusions can never be 100% safe. However, the current blood supply is ... Autologous Blood Donation (Blood from Yourself). Although the blood donated by the general public and used for most people is ...
PRP treatment seems to be an effective treatment for chronic lateral elbow epicondylitis and superior to autologous blood in ... Group A was treated with a single injection of 3 mL of autologous blood and group B with 3 mL of PRP under ultrasound guidance ... Healing of this lesion is reported with the use of autologous blood as well as with platelet-rich plasma (PRP). ... Additionally, the possibility of cost reduction of the method might justify the use of PRP over autologous whole blood for ...
... and resulted in significantly higher blood transfusion requirements (p , 0.05). Lactate, serum creatinine, troponin, and ... Retrograde Autologous Priming as a Safe and Easy Method to Reduce Hemodilution and Transfusion Requirements during Cardiac ... During the last decades many efforts have been made to reduce transfusion requirements and adverse clinical effects during ... cardiopulmonary bypass (CPB). The minimal extracorporeal circulation (MECC) system and the technique of retrograde autologous ...
Indian Journal of Hematology and Blood Transfusion. pp 1-2 , Cite as ... Indian J Hematol Blood Transfus 33(1):31-40CrossRefPubMedPubMedCentralGoogle Scholar ... Indian J Hematol Blood Transfus 33(3):370-374CrossRefPubMedGoogle Scholar ... Indian J Hematol Blood Transfus 33(4):463-469CrossRefPubMedGoogle Scholar ...
Inappropriate Study Design Produces Spurious Effects of Autologous Blood Transfusion. HEUBERGER, JULES A. A. C.; COHEN, ADAM F. ... Cerebral Blood Flow during Interval and Continuous Exercise in Young and Old Men. KLEIN, TIMO; BAILEY, TOM G.; ABELN, VERA; ... Cerebral Blood Flow during Exercise in Heart Failure Effect of Ventricular Assist Devices. SMITH, KURT J.; SUAREZ, IGNACIO M.; ...
Autologous transfusion and the preservation of frozen red blood cells. Tucker, Kenneth R ... The blood supply of the tendon with a paratenon: An experimental study using hydrogen washout technique. Kelleher, John C. ... The Effect of Topical Epinephrine Hydrochloride in Saline on Blood Loss Following Tangential Excision of Burn Wounds. Snelling ... The Effect of Topical Epinephrine Hydrochloride in Saline on Blood Loss Following Tangential Excision of Burn Wounds. Snelling ...
Predictors of allogenic blood transfusion in elective cardiac surgery after preoperative autologous blood donation. In: Surgery ... Predictors of allogenic blood transfusion in elective cardiac surgery after preoperative autologous blood donation. / Takami, ... Predictors of allogenic blood transfusion in elective cardiac surgery after preoperative autologous blood donation. ... Takami Y, Masumoto H. Predictors of allogenic blood transfusion in elective cardiac surgery after preoperative autologous blood ...
Autologous blood transfusion. Linklater. This lecture covers in detail the advantages and disadvantages of autologous blood ... 8:30-9 - Hot Topic: Whole blood or component therapy?. Linklater. Transfusion medicine has evolved over many years, and current ... 9:00-9:50 - Transfusion medicine: Year in Review???. Linklater. Transfusion medicine is a fast-growing field with new studies ... 10:20-Noon - Case studies in imaging, transfusion medicine, fluid therapy, and wellbeing. Boysen & Linklater. This conference ...
autologous blood transfusions. 1 Article. autologous transfusions. 1 Article. automated blood pressure measurements. 1 Article ...
  • On the following day, transfusion of RBC (235 mL) from the second donation or sham transfusion was completed. (
  • Although preoperative autologous blood donation is employed in elective surgery, this is declining because of the increasingly safe allogeneic blood supply. (
  • Preoperative autologous blood donation (PAD) was developed and promoted [ 1 ] in the surgical arena in response to medical and legal pressures to minimize exposure to allogeneic blood. (
  • XTRA has helped over one million patients reduce allogeneic transfusion risks and shorten their hospital stays. (
  • However, it continues to be used because of the public's perception of allogeneic blood risks and increasing blood shortages. (
  • The risks of transfusion-transmitted infection: direct estimation and mathematical modelling. (
  • The risks of transfusion related issues are also lowered, as this is the patient's own blood, not someone else's. (
  • To actually change physicians' practice, a tailored strategy aimed at barriers that hinder physicians in abandoning the use of erythropoietin and perioperative blood salvage was systematically developed. (
  • The primary outcome of the effect evaluation is the percentage of patients undergoing primary elective total hip or knee arthroplasty in which erythropoietin or perioperative blood salvage is applied. (
  • Many studies on the effectiveness of the frequently used BSMs erythropoietin (EPO) and intra- and postoperative drainage and re-infusion of autologous blood (in short: perioperative blood salvage) in orthopedic surgery have been performed. (
  • Reviews and meta-analyses showed that EPO and perioperative blood salvage reduce transfusions. (
  • We designed this study to examine the impact of RAP on perioperative blood product use. (
  • Autologous transfusion or autotransfusion is a technique in which a patient's shed blood is collected and transfused back into the patient. (
  • Since then, autotransfusion has been generally limited to the operating room to wash and return the patient's blood lost during operations and to the austere setting where blood products are not readily available. (
  • To maintain pulmonary blood flow during balloon angioplasty, a 6-F long introducer sheath was advanced to the right pulmonary artery and successfully crossed the lesion to deliver blood, which was collected from the patient's atria and anticoagulated with heparin before BPA. (
  • Our clinical educator is concerned about negative impacts on osmotic pressures as we push to complete the transfusion within the allotted time period and is looking for information that either supports this practice or recommends a different approach - such as transfusing smaller amounts more frequently. (
  • With routine PAD, erythropoiesis of 220-351 ml (11-19% RBC expansion) [ 6 , 7 ], or the equivalent of 1-1.75 blood units, occurs in excess of basal erythropoiesis, which indicates the efficacy of this blood conservation practice. (
  • These components prevent the transmission of transfusion-related blood-borne diseases in patients, and they also provide more compatible blood than in the case of autologous blood transfusions. (
  • Patients may donate a unit of blood (450 ± 45 ml) as often as twice weekly, up to 72 hours before surgery. (
  • A summary of prospective, controlled trials of patients undergoing such blood loss via autologous phlebotomy is presented in Table 2 [ 6 - 11 ], along with calculated estimates of red blood cell (RBC) volume expansion (erythropoiesis in excess of basal rates). (
  • The Placental Blood Program of the New York Blood Center has developed techniques for collecting, testing, freezing and searching units on behalf of unrelated patients in need of hematopoietic stem cell replacement since 1993 and provided analysis of the outcomes of these transplants identified variables associated with clinical outcomes. (
  • Priming of the CPB circuit with the patients' own blood (retrograde autologous priming, RAP) is a technique used to limit hemodilution and reduce transfusion requirements. (
  • A small, statistically insignificant reduction in the percentage of patients receiving packed red blood cells was observed in the RAP group (44% versus 51% no RAP, P = 0.083). (
  • The company s Cell Saver Elite system provides hospitals with an easy-to-use, reliable way to recover and deliver back a patient s own high-quality blood during medium to high blood loss procedures, including cardiac, orthopedic, trauma, transplant, vascular, and OBGYN surgeries. (
  • However, the blood that is being returned to the patient has been processed, resulting in a more concentrated product. (
  • A massive hemothorax can easily cost the patient 1500ml of blood initially and 200-250 ml per hour after that. (
  • This iatrogenic blood loss is accompanied by a response in endogenous erythropoietin (EPO) levels that, although increased significantly over basal levels, remain within the normal range. (
  • Despite evidence that erythropoietin and intra- and postoperative blood salvage are expensive techniques considered to be non-cost-effective in primary elective total hip and knee arthroplasties in the Netherlands, Dutch medical professionals use them frequently to prevent the need for allogeneic transfusion. (
  • This segment is estimated to grow at the highest rate during the forecast period due to the high prevalence of cardiac diseases and recommendations for autologous transfusion (by entities such as the WHO) during cardiac surgeries. (
  • The hospitals in the intervention group will receive a tailored de-implementation strategy that consists of four components: interactive education, feedback in educational outreach visits, electronically sent reports on hospital performance (all aimed at orthopedic surgeons and anesthesiologists), and information letters or emails aimed at other involved professionals within the intervention hospital (transfusion committee, OR-personnel, pharmacists). (
  • Blood typing and banking improvements in the 30s and 40s made autotransfusion less popular, but advances in the washing process of blood in the late 60s brought about a resurgence. (
  • The relative abundance of lab-tested blood products have undercut the interest in Western medicine for exploring autotransfusion further, but researchers have been looking into its possible role in the future of medicine. (
  • Placental blood for bone marrow replacement: the New York Blood Center's program and clinical results. (
  • Placental/umbilical cord blood (PCB) has been used for allogeneic bone marrow replacement since 1988. (
  • Data were collected over a 24-mo period when RAP was routinely used as a blood conservation strategy (RAP group, n = 257). (
  • Direct measurement of the risk of transfusion-transmitted infection (TTI) is practical and accurate only if the level of risk is high. (
  • The residual risk of transfusion-transmitted viral infection in developed countries is considered minimal or negligible. (
  • Total joint replacement surgery such as total hip arthroplasty (THA) and total knee arthroplasty (TKA) is associated with intra- and postoperative blood loss leading to postoperative anemia. (
  • Genomic screening for HCV, HIV and HBV represents a major advance, eliminating infectious blood donations collected during the pre-seroconversion window period, rare cases of immunosilent infections and, possibly, a large spectrum of viral variants. (
  • leukocyte transfusion has been effective in augmenting recipient immunity only in limited clinical situations. (
  • This case is unique in demonstrating that BPA in the major pulmonary artery may transiently block blood circulation and induce ischemic complications such as seizure. (
  • PURPOSE: This study tested the hypothesis that autologous blood transfusion (ABT) of ~50% of the red blood cells (RBC) from a standard 450-mL phlebotomy would increase mean power in a cycling time trial. (
  • In conclusion, RAP is compared with cCPB and MECC a safe and low-cost technique in reducing the priming volume of the CPB system, causes less hemodilution, and reduces the need for intra- and postoperative blood transfusion. (
  • Homologous blood transfusion (HBT) in pediatric cardiac surgery is used most commonly for priming of cardiopulmonary bypass (CPB) system and for postoperative transfusion. (
  • The neonate's autologous cord blood was used for postcardiac surgery blood transfusion to replace postoperative blood loss. (
  • The donor exposure in age and type of cardiac surgery-matched controls showed that the neonates not receiving autologous cord blood had a donor exposure to 5 donors (2 packed red blood cells [PRBCs], including 1 for CPB prime and 1 for postoperative loss, 1 fresh frozen plasma, 1 cryoprecipitate, and 1 platelet concentrate) compared to 1 donor for the AUCB neonate (1 PRBC for the CPB prime). (
  • Postoperative blood loss was similar in both the groups of matched controls and study group. (
  • Conclusions: Use of AUCB for replacement of postoperative blood loss after neonatal cardiac surgery is feasible and reduces donor exposure to the neonate. (
  • We have assessed the effect of the donation of autologous blood and the preoperative level of haemoglobin on the prevalence of postoperative thromboembolism in 2043 patients who had a total hip arthroplasty. (
  • Of those who had donated blood, 0.3% developed a postoperative pulmonary embolism compared with 0.7% in those who had not, but this difference was not statistically significant. (
  • Taken together, H19 accelerated fibroblast activation by recruiting EZH2-mediated histone methylation and modulating the HIF-1α signaling pathway, whereby augmenting the process of modified preservative fluid preserved autologous blood enhancing the postoperative wound healing in diabetic mice. (
  • The objectives of the present study were to investigate the oxygen delivery capacity of autotransfused shed mediastinal blood, compared to patient-blood, during cardiopulmonary bypass and in the postoperative period. (
  • Mediastinal shed blood was collected in the cardiotomy reservoir and retransfused during the first 18 postoperative hours. (
  • Evidence from a variety of sources indicates that allogeneic blood transfusion enhances the survival of renal allografts 1 and may increase the recurrence rate of resected malignancies 2 and the incidence of postoperative bacterial infections, 3-7 as well as reduce the recurrence rate of Crohn disease 8 and/or activate infections with cytomegalovirus 9 or human immunodeficiency virus. (
  • A subsequent hypothesis proposed that, if allogeneic blood transfusion causes immunosuppression, then recipients of perioperative allogeneic blood transfusion could be at increased risk for postoperative bacterial infection. (
  • Since 1981, more than 150 clinical studies have examined the association of perioperative allogeneic blood transfusion with cancer recurrence and/or postoperative bacterial infection. (
  • Between 15 December 2003 and 21 November 2008, 24 children with T1D (10 males, 14 females) underwent a single autologous UCB transfusion. (
  • When someone donates their blood for their own use, it is called autologous blood donation or autotransfusion. (
  • Although blood donated by the general public and used for most people is thought to be very safe, some people choose a method called autologous blood donation. (
  • This is called autologous blood donation. (
  • OBJECTIVE We conducted an open-label, phase I study using autologous umbilical cord blood (UCB) infusion to ameliorate type 1 diabetes (T1D). (
  • Autologous umbilical cord blood (UCB) is an attractive source for potential cell therapies in young children. (
  • To avoid the risks associated with HBT in neonates undergoing cardiac surgery, use of autologous umbilical cord blood (AUCB) transfusion has been described. (
  • Must have a diagnosis of T1D and have stored umbilical cord blood in an AABB and/or FACT accredited cord bank. (
  • CD34 stem cell-rich umbilical cord whole blood transfusion has the potential to have an immediate benefit of better tissue oxygenation with an additional delayed benefit of possible engraftment of umbilical cord stem cells. (
  • Umbilical cord blood (UCB) provides an alternative to mismatched hematopoietic grafts. (
  • Umbilical cord blood is rich in Tregs and therefore has the potential to prevent or delay the onset of type 1 diabetes. (
  • Umbilical cord blood is rich in Tregs, which become functionally suppressive on antigen stimulation, 7 and is also a source of haematopoietic and pluripotent stem cells. (
  • 2. The collection and reinfusion into the patient of blood lost during an operation. (
  • Due to the lack of studies related to the use of autologous blood transfusions in goats, this study was conducted to evaluate the clinical, hematological, and biochemical changes following blood collection and reinfusion in goats. (
  • The clinical, haematological and biochemical parameters were evaluated before blood collection and reinfusion, after 10 minutes of collection and reinfusion, after 3, 6, 12, 24, 48, 96 and 192 hours after collection and reinfusion. (
  • Intraoperative autologous blood collection and reinfusion (Cell Saver or cell salvaging), which occurs when blood you lose during surgery is collected, washed, filtered, and reinfused. (
  • The aim of this study was to assess outcomes in trauma patients receiving whole blood autotransfusion (AT) from hemothorax. (
  • This survey of autologous blood transfusion practices, promoted by the Italian Society of Transfusion Medicine and Immunohaematology more than 2 years after the publication of national recommendations on the subject, was intended to acquire information on the indications for predeposit in Italy and on some organisational aspects of the alternative techniques of autotransfusion. (
  • Autotransfusion after open heart surgery: the oxygen delivery capacity of shed mediastinal blood is maintained. (
  • Autotransfusion of mediastinal shed blood after open heart surgery has become a common and accepted procedure in reducing the need for homologous transfusion during the last 15 years. (
  • Shed blood had a mean haemoglobin level of 8.8 g/dl and 7.4 g/dl at 1 h and 6 h of autotransfusion, respectively. (
  • There were no significant changes of 2,3-DPG concentration in the patient-blood during cardiopulmonary bypass or after autotransfusion compared to preoperative values. (
  • The results demonstrate that the oxygen delivery capacity of shed mediastinal blood is maintained and that the oxygen affinity of patient-blood is not influenced by autotransfusion. (
  • 0.05) following blood reinfusion and decreased 48 h thereafter. (
  • 0.05), with a nonsignificant reduction in blood loss (median 2.6 L [range 0.9-5.4 L] in the ROTEM-TXA group vs 2.9 L [0.7-7.0 L] in the Conventional-TXA group, p = 0.21). (
  • illustrate the clinical and fiscal benefits of institution of a multi-disciplinary intraoperative autologous blood donation program. (
  • We investigated the effect of intraoperative autologous donation (IAD) on need for homologous transfusion post-coronary artery bypass graft surgery (CABG). (
  • Laparoscopic myomectomy was successfully performed with local injection of vasopressin and intraoperative autologous blood transfusion. (
  • The second receptacle may comprise a transfer bag for reinfusion into the patient or an infusion set may be connected to the second receptacle to permit simultaneous collection of the blood from the patient and infusion of the blood back into the patient. (
  • Legitimate autologous transfusion is also used by patients awaiting elective surgical procedures as a way of reducing the risks associated with homologous transfusions - transfusions of blood from a blood donor. (
  • Autologous transfusion can eliminate the need for homologous transfusions. (
  • Her family's religious convictions precluded homologous transfusions. (
  • Structured Abstract - OBJECTIVE: To assess the effect of transfusion using a syringe and microaggregate filter on short-term survival and circulating half-life of autologous feline RBCs. (
  • Sixty ASA I-II (American Society of Anesthesiologists) patients undergoing elective radical resection for stomach cancer were randomly allocated to receive either allogeneic blood transfusion (n=30) or autologous blood transfusion (n=30). (
  • Zurück zum Zitat Boralessa H, Goldhill DR, Tucker K, Mortimer AJ, Grant-Casey J (2009) National comparative audit of blood use in elective primary unilateral total hip replacement surgery in the UK. (
  • These animals need differential treatment, such as elective surgical procedures that lead to a loss of blood, for which autologous transfusion is the best fit. (
  • We investigated the predictors of blood component usage during elective cardiac surgery in patients prepared with PAD. (
  • Conclusion: Even with PAD for elective cardiac surgery, patients whose pre-donation hemoglobin value and preoperative platelet count are low may require allogenic blood transfusion. (
  • Takami, Y & Masumoto, H 2009, ' Predictors of allogenic blood transfusion in elective cardiac surgery after preoperative autologous blood donation ', Surgery Today , vol. 39, no. 4, pp. 306-309. (
  • Pre-operative donation of autologous blood is a practice that is now being abandoned. (
  • The effect of preoperative donation of autologous blood on deep-vein thrombosis after total hip arthroplasty. (
  • The purpose of this study is to test the safety and effectiveness of a cord blood infusion in children who have motor disability due to cerebral palsy (CP). (
  • The subjects will be children whose parents have saved their infant's cord blood, who have non-progressive motor disability, and whose parents intend to have a cord blood infusion. (
  • The purpose of this study is to conduct an observer-blinded crossover investigation of the safety and efficacy of autologous cord blood infusion in children who demonstrate non-progressive motor disability due to brain dysfunction (commonly called cerebral palsy) and who do not have an apparent disorder of brain development or obstructive hydrocephalus. (
  • Confirm the efficacy of autologous cord blood infusion in children with cerebral palsy using patient questionnaire and standardized Gross Motor Function Measure evaluation. (
  • The collected bag with 70-75 mL cord blood was stored at 2°C-6°C and tested for blood grouping and infections after proper labeling. (
  • Endothelial Progenitor Cells from Cord Blood: Magic Bullets Against Ischemia? (
  • While this study is now completely enrolled, we do hope to develop a 'next generation' cord blood based study sometime in early 2009. (
  • Please continue to contact us if you have a child with newly diagnosed Type 1 Diabetes (T1D) who alo has their OWN cord blood in storage. (
  • Baseline and post-infusion mixed meal tolerance tests were performed to determine whether autologous cord blood infusion preserved endogenous insulin production. (
  • Cord blood meets all selection and testing criteria (see below). (
  • Cord blood is a significant source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. (
  • Cord blood is also an alternative to embryos as a source of tissue for regenerative medicine. (
  • Cells from cord blood. (
  • Cells from cord blood have been shown to transdifferentiate into nonhematopoietic cells, including those of the brain, heart, liver, pancreas, bone, and cartilage, in tissue culture and in animal systems. (
  • Recently it has been demonstrated that both cardiac and glial cell differentiation of cord blood donor cells occurred in recipients of unrelated donor cord blood transplantation as part of a treatment regime for Krabbe disease and Sanfilippo syndrome. (
  • These observations raise the possibility that cord blood may serve as a source of cells to facilitate tissue repair and regeneration in the future. (
  • Cell dose is a critical determinant of outcomes in unrelated cord blood (CB) transplantation. (
  • 2 Cord blood (CB) procurement is fast and there are reports indicating a reduced incidence of severe GVHD. (
  • A pilot trial is currently underway in Australia to examine whether infusion of autologous cord blood can prevent type 1 diabetes in high-risk children with serum antibodies to multiple β -cell antigens. (
  • However, the use of publicly stored cord blood for research in Australia is currently limited by policy that restricts its use to recognised indications, including allogeneic haematopoietic stem cell transplantation for oncological, haematological, genetic and immunological disorders. (
  • There are also specific ethical issues associated with the collection and storage of cord blood, including storage (public v private), informed consent (from whom, when and how? (
  • 8 Thus, there is a strong scientific rationale behind the potential for cord blood to prevent or delay the onset of type 1 diabetes. (
  • In parallel, the trial will study the immunological effects of cord blood infusion. (
  • This is the first time such a trial will be undertaken for the prevention of type 1 diabetes in humans, although studies have used autologous cord blood after the onset of type 1 diabetes. (
  • In a Phase I trial involving 24 children (median age, 5.1 years) with type 1 diabetes, 9 infusion of autologous cord blood after a median diabetes duration of 3 months was associated with a transient increase in total and naive Tregs at 6 and 9 months, respectively. (
  • This lecture covers in detail the advantages and disadvantages of autologous blood transfusions (ABT), including videos that demonstrate step-by-step instructions on how to perform ABTs, as well as indications and complications associated with ABT. (
  • In-hospital complications were defined as adult respiratory distress syndrome, sepsis, disseminated intravascular coagulation, renal insufficiency, and transfusion-related acute lung injury. (
  • Transfusion of autologous blood is associated with fewer complications, although all untoward events of transfusion may not be negated with this strategy. (
  • Red blood cells, the most commonly transfused part, are used to increase the blood's ability to carry oxygen and prevent tiredness and other complications. (
  • To prevent complications from an existing blood or bleeding disorder , such as sickle cell disease , thalassemia, or anemia caused by kidney disease , hemophilia , or von Willebrand disease . (
  • Frequent transfusions, however, can cause serious complications due to iron toxicity and viral infections. (
  • 4 Immunological Complications of Transfusion ( Clare Taylor, Cristina Navarrete, Marcela Contreras ). (
  • Beta-thalassemia is a blood disorder caused by a mutation in the HBB gene that reduces production of the protein hemoglobin, which affects the blood's ability to transport oxygen and is associated with life-threatening complications such as severe anemia and organ damage. (
  • However, transfusion-related complications such as iron overload can be deadly. (
  • These important results show that gene therapy is a promising new option for reducing or eliminating blood transfusions and limiting long-term complications of transfusions in patients with this disease," says Dr. Mark C. Walters, Director of the Blood & Marrow Transplantation (BMT) program at UCSF Benioff Children's Hospital Oakland and lead investigator of the Northstar study. (
  • Indian Journal of Hematology and Blood Transfusion is a medium for propagating and exchanging ideas within the medical community. (
  • The Journal is the official publication of The Indian Society of Hematology & Blood Transfusion. (
  • II-12 Growing Need for Blood Propels Demand for Blood Collection Tubes II-13 Reagents - Key to Functionality of Hematology Analyzers II-13 Increasing Cancer Incidence Drives Use of Apheresis Equipment and Supplies. (
  • We saw remarkable outcomes using LentiGlobin gene therapy, with most patients no longer needing monthly transfusions," said leading author Alexis Thompson, MD, Head of Hematology and Director of the Comprehensive Thalassemia Program at Ann & Robert H. Lurie Children's Hospital of Chicago, as well as Professor of Pediatrics at Northwestern University Feinberg School of Medicine. (
  • Based on your statement that only processing fees are charged for allogeneic blood, you do not have to use -BL modifier and the two revenue codes (038X and 039X). (
  • This indirect method allows detection of blood transfusion for up to two weeks and can detect all forms of blood doping, including abuse of recombinant erythropoietin (rhEPO), erythropoiesis stimulating agents (ESAs), and allogeneic transfusions. (
  • 2 - 4 Unfortunately, the success of this method has caused athletes to adopt more complex blood doping regimens to evade detection. (
  • 6 The study herein was therefore designed to identify new serum markers that may improve detection of banned blood doping practices. (
  • 8 sTFR was previously used for anti-doping detection of rhEPO abuse and has demonstrated significant increases upon blood withdrawal. (
  • Thus, the use of these serum markers for detection of autologous blood transfusion warrants further analysis. (
  • Outcome of conditioning intensity in acute myeloid leukemia with monosomal karyotype in patients over 45 year‐old: A study from the acute leukemia working party (ALWP) of the European group of blood and marrow transplantation (EBMT) pp. (
  • 24 25 These studies are based on the assumption that the transfusion of autologous 2 4 21 23 or WBC-reduced 3 5-7 22 RBCs, or whole blood, is immunologically neutral. (
  • The blood is centrifuged, the plasma components are immediately reinfused, and the corpuscular elements, principally red blood cells (RBCs), are stored refrigerated at 4 °C or frozen at −80 °C. As blood stored by refrigeration displays a steady decline in the number of RBCs, a substantial percentage, up to 40%, of the stored RBCs may not be viable. (
  • The freezing process, conversely, limits the aging of the cells, allowing the storage of the blood for up to 10 years with a 10% to 15% loss of RBCs. (
  • RBCs were washed and labeled at two different biotin densities, before suspension in autologous plasma. (
  • There was no difference in probability that the RBCs would survive up to 12 hours immediately following transfusion, and no significant difference in survival between the two groups over 6 weeks. (
  • CONCLUSIONS: We conclude that, in contrast to findings from dogs, transfusion of autologous feline RBCs using a syringe + aggregate filter method does not significantly impact short- or long-term survival of the transfused cells. (
  • No adverse events were observed in association with autologous UCB infusion. (
  • Participation in these systems is voluntary, but NSQHS Standards mandate that hospitals have systems in place for recognising and reporting transfusion-related incidents and adverse events. (
  • Estimates of infectious and non-infectious hazards are reported periodically by the Australian Red Cross Blood Service ( ). (
  • Volunteer donor blood usually is readily available, and when properly tested has a low incidence of adverse events. (
  • Treatment-related adverse events were typical of autologous stem cell transplantation. (
  • No significant adverse events were noted in the autologous patients. (
  • A number of studies have showed a decreased incidence of post-operative infections in patients receiving autologous salvaged blood as compared to patients receiving homologous blood or autologous washed blood. (
  • Lancet, 2004) show an increase of Natural Killer Cell Precursors in patients receiving autologous filtered blood, suggesting that the blood contains immunostimulants. (
  • On the basis of preclinical efficacy and safety data, we performed an unblinded observational pilot study to determine whether autologous UCB infusion could preserve remaining endogenous insulin production. (
  • Kumar L, Boya RR, Pai R et al (2016) Autologous stem cell transplantation for multiple myeloma: long-term results. (
  • Malhotra P, Yanamandra U, Khadwal A et al (2017) Autologous stem cell transplantation for multiple myeloma: single centre experience from North India. (
  • Dr. Mark C. Walters of UCSF Benioff Children's Hospital Oakland has been the lead researcher for the Northstar Study (HGB-204): A Phase I/II Study of Gene Therapy for Beta-Thalassemia Major via Transplantation of Autologous Hematopoietic Stem Cells Transduced Ex-Vivo with a Lentiviral Beta AT87Q-Globin Vector (LentiGlobin BB305 Drug Product). (
  • Allogeneic transplantation is a procedure in which a person receives hematopoietic (blood-forming) or blood stem cells, from a genetically similar, but not identical, donor. (
  • Effect of perioperative autologous versus allogeneic blood transfusion on the immune system in gastric cancer patients. (
  • Autologous blood transfusion might be significantly beneficial for immune-compromised patients in the perioperative period, clearly showing its superiority over allogeneic blood transfusion. (
  • Both the earlier observational cohort studies and the recent RCTs have produced contradictory findings, and-because of the discrepancies among the published studies-the long-standing hypothesis of the potentially deleterious immunomodulatory effect of perioperative allogeneic blood transfusion remains unresolved. (
  • RESEARCH DESIGN AND METHODS A total of 24 T1D patients (median age 5.1 years) received a single intravenous infusion of autologous UCB cells and underwent metabolic and immunologic assessments. (
  • CONCLUSIONS Autologous UCB infusion in children with T1D is safe and induces changes in Treg frequency but fails to preserve C-peptide. (
  • We conclude that the observed transfusion-related acute lung injury reaction with significant hypotension may be the result of two independent events: the first is related to inherent host factors, in this case major surgery, and the second is the infusion of lipids that accumulate during the routine storage of PRBCs. (
  • Allogeneic blood transfusion results in the infusion into the recipient of large amounts of foreign antigens in both soluble and cell-associated forms. (
  • Dr Shander lectures nationally and internationally on a variety of topics relating to blood conservation, volume resuscitation, acute anemia therapy, surgical blood management, acute normovolemic hemodilution and bloodless medicine and surgery. (
  • Alterations in the Surgical Patient NRS 121 Lisa M. Dunn MSN/ED, RN, CCRN, CNE A surgical drain is a tube used to remove pus, blood or other fluids from a wound. (
  • A cryoprecipitate transfusion may be used if certain conditions lower the blood-clotting factors. (
  • A cryoprecipitate transfusion may also be used if fibrinogen is lowered. (
  • Prinja S, Kaur G, Malhotra P et al (2017) Cost-effectiveness of autologous stem cell treatment as compared to conventional chemotherapy for treatment of multiple myeloma in India. (
  • the introduction of whole blood or blood components directly into the bloodstream. (
  • Blood is made up of different parts, or components. (
  • A blood transfusion may give whole blood, which includes all of the components of blood. (
  • In the hospital outpatient setting, the 'P' code -BL modifier is to be used for Revenue Codes 038X plus 039X when the hospital receives allogeneic blood components from suppliers that charge for the liquid blood or collects their own blood and charges for the liquid blood as well as for processing fees (the outmoded 'replacement fees' charged by some facilities would fall in this category). (
  • Revenue Code 0390 (or 0391 for Blue Cross/Blue Shield) is the appropriate revenue code when charging for transfused allogeneic/autologous blood components. (
  • Your FI is correct, a blood component HCPCS code ('P' code) should be attached to this revenue code when billing for transfused blood components as well as CPT 36430 once per day per transfused patient in the hospital outpatient setting. (
  • FDA has recommended that whole blood and blood components for transfusion be obtained from U.S. areas without active Zika virus transmission. (
  • Outsourcing of blood components from unaffected areas might not be feasible if there is widespread Zika virus transmission in heavily populated areas of the continental United States. (
  • Participants will be able to manage patients receiving blood and blood components, including the identification of adverse reactions, and indications and contraindications for use. (
  • 2 Allogeneic Blood Components ( Rebecca Cardigan & Sheila MacLennan ). (
  • 6 Pathogen Inactivation (of Blood Components) ( Chris Prowse ). (
  • Autologous transplants can also be used as part of gene therapy for disorders of the immune system. (
  • In patients who undergo allogeneic stem cell transplants, epoetin consistently results in a statistically significant decrease in the time to red blood cell engraftment, the report said, and may decrease the number of red blood cell units transfused. (
  • There was no evidence to show that epoetin administered to patients who receive autologous stem-cell transplants has any beneficial effect on RBC engraftment, RBC transfusion, or length of hospital stay. (
  • Autologous transplants are the most common of the BMT treatments. (
  • This patient had a hemoabdomen and was receiving the transfusion to restore intravascular volume and red blood cells. (
  • We know from testimonies given by athletes that autologous transfusions are the most effective way of increasing red blood cells, and therefore oxygen capacity, in an athlete's blood stream. (
  • 7 Following blood transfusion, older red blood cells are absorbed by macrophages where the hemoglobin iron is recycled and released into the circulation. (
  • Blood, one unit, was leukodepleted and stored as approximately 250 ml of packed red cells at 4°C for 21 days. (
  • We have received conflicting information on whether P9016 Red blood cells, leukocytes reduced, each unit , qualifies for the blood deductible, and the correct revenue code it belongs in. (
  • Medicare defines items subject to the blood deductibles as whole blood and packed red cells . (
  • Medicare does not limit the type of red blood cells by further refining the definition. (
  • PURPOSE: This study tested the hypothesis that autologous blood transfusion (ABT) of ~50% of the red blood cells (RBC) from a standard 450-mL phlebotomy would increase mean power in a cycling time trial. (
  • Whole blood, packed red blood cells and other blood products replenish volume, oxygen-carrying capacity, platelet volume, and clotting factors. (
  • We report a case of acute pulmonary insufficiency and hypotension following transfusion of autologous packed red blood cells (PRBCs) in a patient, who was undergoing major surgery. (
  • In addition, hypotensive anesthesia and devices that salvage red blood cells for return to the patient can reduce operative blood loss. (
  • Red blood cells carry oxygen to the body's tissues and remove carbon dioxide. (
  • There are four major blood types, each with a different chemical marker that's attached to a person's red blood cells. (
  • Some illnesses and treatments can harm the bone marrow's ability to make blood (e.g., chemotherapy decreases production of new blood cells). (
  • It is known that tissue regeneration with appropriate angiogenesis plays a crucial role in chronic wound healing since blood vessels can provide the sites of tissue regeneration for soluble factors, circulating stem or progenitor cells and nutrients and they can help remove waste products [ 7 ]. (
  • Most of the time a transfusion is not a 'whole blood' transfusion, but rather certain blood products, with red blood cells being the most common. (
  • This is usually done as a lifesaving maneuver to replace blood cells or blood products lost through severe bleeding, during surgery when blood loss occurs or to increase the blood count in an anemic patient. (
  • People with thalassemia cannot make enough hemoglobin in their red blood cells, which interferes with oxygen getting to all parts of the body. (
  • Gantt's hypothesis was based on the premise that, if allogeneic blood transfusion down-regulated the host's immune surveillance mechanism that targets malignant cells, the receipt of allogeneic blood transfusion could enhance tumor growth. (
  • Blood-making cells are produced in the spongy area of bones known as marrow. (
  • These cells develop into all types of blood cells in the body. (
  • This therapy may injure or destroy the child's normal blood cells. (
  • Another method uses blood-making cells that circulate throughout the body. (
  • At the same time these therapies kill cancer cells, they can also destroy many healthy blood cells. (
  • The cells travel through the blood until they reach the marrow and start growing new, healthy cells. (
  • Most of the iron in the body is found in the hemoglobin of red blood cells and in the myoglobin of muscle cells. (
  • Iron helps red blood cells carry oxygen from the lungs to cells all over the body. (
  • Taking iron along with other medications such as epoetin alfa can help build red blood cells and prevent or treat anemia in people with kidney problems or being treated for cancer with chemotherapy. (
  • Blood doping is the practice of boosting the number of red blood cells in the bloodstream in order to enhance athletic performance. (
  • Because such blood cells carry oxygen from the lungs to the muscles, a higher concentration in the blood can improve an athlete's aerobic capacity (VO2 max) and endurance. (
  • Blood doping can be achieved by making the body produce more red blood cells itself using drugs, giving blood transfusions either from another person or back to the same individual, or by using blood substitutes. (
  • Myo-inositol trispyrophosphate (ITPP), also known as compound number OXY111A, is an allosteric effector of hemoglobin which causes a rightward shift in the oxygen-hemoglobin dissociation curve, increasing the amount of oxygen released from red blood cells into surrounding tissue during each passage through the cardiovascular system. (
  • Transfusion with labeled, autologous, fresh red blood cells. (
  • Haemoglobin is the protein in red blood cells that carries oxygen around the body. (
  • Erythropoietin is also used before surgery to increase the number of red blood cells to help patients produce more blood for self-donation. (
  • who is on Chemotherapy and has very low Wht blood cells? (
  • Dr. Walters collected stem cells from transfusion-dependent beta-thalassemia major patients, inserted the healthy gene, and then infused the cells back into the patient after first giving high-dose chemotherapy to destroy the thalassemia-producing blood cells. (
  • Thalassemia is an inherited disorder that affects the production of normal hemoglobin (a type of protein in red blood cells that carries oxygen to the tissues of the body). (
  • Patients who received AT had significantly lower packed red blood cell (p = 0.01) and platelet requirements (p = 0.01). (
  • Values of hemoglobin, total leukocyte count, platelet counts, and blood gas parameters were also similar. (
  • Before skin suture, randomization was performed, and 16 patients were injected with 10 mL PRP (10 times higher platelet concentration than peripheral blood) whereas 14 were not. (
  • Platelet concentrates may be derived either from single units of whole blood or by using a cell separator. (
  • BACKGROUND: The practice of transfusing ones' own shed whole blood has obvious benefits such as reducing the need for allogeneic transfusions and decreasing the need for other fluids that are typically used for resuscitation in trauma. (
  • It also reduced the need for allogeneic transfusions and decreased hospital costs. (
  • Blood conserving techniques are an important aspect of limiting transfusion requirements. (
  • We obtained 500ml fresh whole blood from the IAD patients while the patients were prepared for anesthesia in the operating room. (
  • Patients with sickle cell disease can be given hypotensive anesthesia and autologous transfusions of blood donated before surgery and blood salvaged during surgery using a cell-saving device. (
  • Treatment with LentiGlobin® is given as an autologous stem cell transplant. (
  • Alternative techniques (acute isovolaemic haemodilution and peri-operative blood salvage) are used at different frequencies across the country. (
  • Autologous PRP stimulates healing of acute Achilles tendon ruptures. (
  • In most other instances, the person cannot donate their own blood due to the acute nature of the need for blood. (
  • Recent studies focus on the positive effects autologous salvaged blood has on the immune system, as opposed to both homologous and autologous washed blood. (
  • Conclusions: It seems that IAD can reduce homologous blood transfusion (although not significantly), but for prevention of bleeding some simple points such as mild hypothermia instead of moderate hypothermia, reduced heparin dose with newer tubing systems and oxygenators and precise hemostasis are more prominent. (
  • However, blood from patients with sickle cell disease is difficult to store. (
  • According to the results of our study, autologous blood transfusion is an efficient method that reduces allogeneic blood usage significantly in our circumstances as well. (
  • Results: The present study demonstrated that IAD did not significantly reduce post-operative mediastinal bleeding, although it had a positive effect on reducing homologous transfusion. (
  • Cost of transfusions (p = 0.01) was significantly lower in the AT group compared with the No-AT group. (
  • P50 for oxygen (3.6 and 3.6 kPa) and 2,3-DPG concentrations (5.3 and 5.1 mikromol/ml erythrocyte) in shed mediastinal blood (1h and 6h postoperatively) were not significantly different compared to patient-blood. (
  • 7 The Benefits of Allogeneic Erythrocyte Transfusion: What Evidence Do We Have? (
  • The modified preservative fluid preserved autologous blood increased the H19 expression in fibroblasts, and maintained better oxygen-carrying and oxygen release capacities as well as coagulation function. (
  • In this study, the authors sought to characterize the coagulation abnormalities encountered in spine surgery and determine whether a ROTEM-guided, protocol-based approach to transfusion reduced blood loss and blood product use and cost. (
  • Allogeneic blood transfusion-induced immunomodulation (TRIM) and its adverse effect on the prognosis of patients treated surgically for cancer remain complex and controversial. (
  • 5 Immunomodulation and Allogeneic Transfusion ( M. Waanders, L. van de Watering, A. Brand ). (
  • Autologous transfusion, recombinant factor vila, and bloodless medicine. (
  • ROCKVILLE, Md-Epoetin alfa, or recombinant human erythropoietin (Epogen, Procrit), reduces the need for red blood cell (RBC) transfusions among cancer patients with chemotherapy-induced anemia, a report prepared for the Agency for Healthcare Research and Quality (AHRQ) concludes. (