AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth CareGeographicals
Malaria VaccinesPlasmodium falciparumMalaria, FalciparumSporozoitesAntigens, ProtozoanVaccinesVaccines, InactivatedViral VaccinesVaccines, SyntheticVaccines, CombinedVaccines, DNAProtozoan ProteinsBacterial VaccinesLife Cycle StagesMalariaPlasmodium yoeliiAIDS VaccinesPlasmodium bergheiAntibodies, ProtozoanMerozoitesVaccines, SubunitVaccines, ConjugateVaccinationPlasmodiumMerozoite Surface Protein 1Plasmodium chabaudiSchizontsPapillomavirus VaccinesErythrocytesParasitemiaMeningococcal VaccinesPlasmodium vivaxHepatitis B VaccinesParasitesReproduction, AsexualMeasles VaccinePertussis VaccineAluminum HydroxideHaemophilus VaccinesBCG VaccineAdjuvants, ImmunologicPoliovirus Vaccine, InactivatedRabies VaccinesEosine I BluishAntimalarialsRotavirus VaccinesImmunizationMaliCholera VaccinesMalaria, VivaxOocystsMice, Inbred BALB CGenes, ProtozoanImmunoglobulin GTyphoid-Paratyphoid VaccinesSmallpox VaccineTuberculosis VaccinesAntibodies, ViralPlasmodium knowlesiChickenpox VaccineDiphtheria-Tetanus-Pertussis VaccineMumps VaccineHepatitis A VaccinesImmunization ScheduleImmunization, SecondaryMeasles-Mumps-Rubella VaccineSaimiriTrophozoitesStreptococcal VaccinesFluoroacetatesAnthrax VaccinesDengue VaccinesMolecular Sequence DataVaccines, VirosomeEnzyme-Linked Immunosorbent AssayAmino Acid SequenceViral Hepatitis VaccinesPoliovirus Vaccine, OralYellow Fever VaccineAntibodies, BacterialPlague VaccinePrimaquineGenome, ProtozoanAnophelesFungal VaccinesHost-Parasite InteractionsPoxviridaeRubella VaccineChloroquineVaccines, AcellularCross ReactionsSAIDS VaccinesSalmonella VaccinesVaccines, Virus-Like ParticleEbola VaccinesCulicidaeInfluenza, HumanInterferon-gammaAntibodies, NeutralizingStaphylococcal VaccinesDiphtheria-Tetanus-acellular Pertussis VaccinesCytomegalovirus VaccinesMice, Inbred C57BLImmunization ProgramsInjections, IntramuscularAntigens, SurfaceDiphtheria-Tetanus VaccinePoliovirus VaccinesAdministration, IntranasalEscherichia coli VaccinesWest Nile Virus VaccinesDNA, ProtozoanParasitic Sensitivity TestsHemagglutination Inhibition TestsShigella VaccinesNeutralization TestsAntibody Formation
Malaria Vaccines: Vaccines made from antigens arising from any of the four strains of Plasmodium which cause malaria in humans, or from P. berghei which causes malaria in rodents.Plasmodium falciparum: A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics.Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.Sporozoites: The product of meiotic division of zygotes in parasitic protozoa comprising haploid cells. These infective cells invade the host and undergo asexual reproduction producing MEROZOITES (or other forms) and ultimately gametocytes.Antigens, Protozoan: Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.Vaccines: Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases.Vaccines, Inactivated: Vaccines in which the infectious microbial nucleic acid components have been destroyed by chemical or physical treatment (e.g., formalin, beta-propiolactone, gamma radiation) without affecting the antigenicity or immunogenicity of the viral coat or bacterial outer membrane proteins.Viral Vaccines: Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.Vaccines, Synthetic: Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.Vaccines, Combined: Two or more vaccines in a single dosage form.Vaccines, DNA: Recombinant DNA vectors encoding antigens administered for the prevention or treatment of disease. The host cells take up the DNA, express the antigen, and present it to the immune system in a manner similar to that which would occur during natural infection. This induces humoral and cellular immune responses against the encoded antigens. The vector is called naked DNA because there is no need for complex formulations or delivery agents; the plasmid is injected in saline or other buffers.Protozoan Proteins: Proteins found in any species of protozoan.Bacterial Vaccines: Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease.Life Cycle Stages: The continuous sequence of changes undergone by living organisms during the post-embryonic developmental process, such as metamorphosis in insects and amphibians. This includes the developmental stages of apicomplexans such as the malarial parasite, PLASMODIUM FALCIPARUM.Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.Plasmodium yoelii: A species of PLASMODIUM causing malaria in rodents.AIDS Vaccines: Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent or treat AIDS. Some vaccines containing antigens are recombinantly produced.Plasmodium berghei: A protozoan parasite of rodents transmitted by the mosquito Anopheles dureni.Antibodies, Protozoan: Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.Merozoites: Uninuclear cells or a stage in the life cycle of sporozoan protozoa. Merozoites, released from ruptured multinucleate SCHIZONTS, enter the blood stream and infect the ERYTHROCYTES.Vaccines, Subunit: Vaccines consisting of one or more antigens that stimulate a strong immune response. They are purified from microorganisms or produced by recombinant DNA techniques, or they can be chemically synthesized peptides.Vaccines, Conjugate: Semisynthetic vaccines consisting of polysaccharide antigens from microorganisms attached to protein carrier molecules. The carrier protein is recognized by macrophages and T-cells thus enhancing immunity. Conjugate vaccines induce antibody formation in people not responsive to polysaccharide alone, induce higher levels of antibody, and show a booster response on repeated injection.Vaccination: Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.Plasmodium: A genus of protozoa that comprise the malaria parasites of mammals. Four species infect humans (although occasional infections with primate malarias may occur). These are PLASMODIUM FALCIPARUM; PLASMODIUM MALARIAE; PLASMODIUM OVALE, and PLASMODIUM VIVAX. Species causing infection in vertebrates other than man include: PLASMODIUM BERGHEI; PLASMODIUM CHABAUDI; P. vinckei, and PLASMODIUM YOELII in rodents; P. brasilianum, PLASMODIUM CYNOMOLGI; and PLASMODIUM KNOWLESI in monkeys; and PLASMODIUM GALLINACEUM in chickens.Merozoite Surface Protein 1: A surface protein found on Plasmodium species which induces a T-cell response. The antigen is polymorphic, sharing amino acid sequence homology among PLASMODIUM FALCIPARUM; PLASMODIUM CHABAUDI; PLASMODIUM VIVAX; and PLASMODIUM YOELII.Plasmodium chabaudi: A protozoan parasite of rodents transmitted by the mosquito Anopheles stephensi.Schizonts: Multinucleate cells or a stage in the development of sporozoan protozoa. It is exemplified by the life cycle of PLASMODIUM FALCIPARUM in the MALARIA infection cycle.Papillomavirus Vaccines: Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Parasitemia: The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)Meningococcal Vaccines: Vaccines or candidate vaccines used to prevent infection with NEISSERIA MENINGITIDIS.Plasmodium vivax: A protozoan parasite that causes vivax malaria (MALARIA, VIVAX). This species is found almost everywhere malaria is endemic and is the only one that has a range extending into the temperate regions.Hepatitis B Vaccines: Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepatitis B. Some vaccines may be recombinantly produced.Parasites: Invertebrate organisms that live on or in another organism (the host), and benefit at the expense of the other. Traditionally excluded from definition of parasites are pathogenic BACTERIA; FUNGI; VIRUSES; and PLANTS; though they may live parasitically.Reproduction, Asexual: Reproduction without fusion of two types of cells, mostly found in ALGAE; FUNGI; and PLANTS. Asexual reproduction occurs in several ways, such as budding, fission, or splitting from "parent" cells. Only few groups of ANIMALS reproduce asexually or unisexually (PARTHENOGENESIS).Measles Vaccine: A live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had measles or been immunized with live measles vaccine and have no serum antibodies against measles. Children are usually immunized with measles-mumps-rubella combination vaccine. (From Dorland, 28th ed)Pertussis Vaccine: A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)Aluminum Hydroxide: A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc.Haemophilus Vaccines: Vaccines or candidate vaccines containing antigenic polysaccharides from Haemophilus influenzae and designed to prevent infection. The vaccine can contain the polysaccharides alone or more frequently polysaccharides conjugated to carrier molecules. It is also seen as a combined vaccine with diphtheria-tetanus-pertussis vaccine.BCG Vaccine: An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.Adjuvants, Immunologic: Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.Poliovirus Vaccine, Inactivated: A suspension of formalin-inactivated poliovirus grown in monkey kidney cell tissue culture and used to prevent POLIOMYELITIS.Rabies Vaccines: Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.Eosine I Bluish: A red fluorescein dye used as a histologic stain. It may be cytotoxic, mutagenic, and inhibit certain mitochondrial functions.Antimalarials: Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)Rotavirus Vaccines: Vaccines or candidate vaccines used to prevent infection with ROTAVIRUS.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Mali: A country in western Africa, east of MAURITANIA and south of ALGERIA. Its capital is Bamako. From 1904-1920 it was known as Upper Senegal-Niger; prior to 1958, as French Sudan; 1958-1960 as the Sudanese Republic and 1959-1960 it joined Senegal in the Mali Federation. It became an independent republic in 1960.Cholera Vaccines: Vaccines or candidate vaccines used to prevent infection with VIBRIO CHOLERAE. The original cholera vaccine consisted of killed bacteria, but other kinds of vaccines now exist.Malaria, Vivax: Malaria caused by PLASMODIUM VIVAX. This form of malaria is less severe than MALARIA, FALCIPARUM, but there is a higher probability for relapses to occur. Febrile paroxysms often occur every other day.Oocysts: Zygote-containing cysts of sporozoan protozoa. Further development in an oocyst produces small individual infective organisms called SPOROZOITES. Then, depending on the genus, the entire oocyst is called a sporocyst or the oocyst contains multiple sporocysts encapsulating the sporozoites.Mice, Inbred BALB CGenes, Protozoan: The functional hereditary units of protozoa.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Typhoid-Paratyphoid Vaccines: Vaccines used to prevent TYPHOID FEVER and/or PARATYPHOID FEVER which are caused by various species of SALMONELLA. Attenuated, subunit, and inactivated forms of the vaccines exist.Smallpox Vaccine: A live VACCINIA VIRUS vaccine of calf lymph or chick embryo origin, used for immunization against smallpox. It is now recommended only for laboratory workers exposed to smallpox virus. Certain countries continue to vaccinate those in the military service. Complications that result from smallpox vaccination include vaccinia, secondary bacterial infections, and encephalomyelitis. (Dorland, 28th ed)Tuberculosis Vaccines: Vaccines or candidate vaccines used to prevent or treat TUBERCULOSIS.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Plasmodium knowlesi: A protozoan parasite from Southeast Asia that causes monkey malaria. It is naturally acquired by man in Malaysia and can also be transmitted experimentally to humans.Chickenpox Vaccine: A live, attenuated varicella virus vaccine used for immunization against chickenpox. It is recommended for children between the ages of 12 months and 13 years.Diphtheria-Tetanus-Pertussis Vaccine: A vaccine consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and whole-cell PERTUSSIS VACCINE. The vaccine protects against diphtheria, tetanus, and whooping cough.Mumps Vaccine: Vaccines used to prevent infection by MUMPS VIRUS. Best known is the live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had mumps or been immunized with live mumps vaccine. Children are usually immunized with measles-mumps-rubella combination vaccine.Hepatitis A Vaccines: Vaccines or candidate vaccines used to prevent infection with hepatitis A virus (HEPATOVIRUS).Immunization Schedule: Schedule giving optimum times usually for primary and/or secondary immunization.Immunization, Secondary: Any immunization following a primary immunization and involving exposure to the same or a closely related antigen.Measles-Mumps-Rubella Vaccine: A combined vaccine used to prevent MEASLES; MUMPS; and RUBELLA.Saimiri: A genus of the family CEBIDAE consisting of four species: S. boliviensis, S. orstedii (red-backed squirrel monkey), S. sciureus (common squirrel monkey), and S. ustus. They inhabit tropical rain forests in Central and South America. S. sciureus is used extensively in research studies.Trophozoites: Cells or feeding stage in the life cycle of sporozoan protozoa. In the malarial parasite, the trophozoite develops from the MEROZOITE and then splits into the SCHIZONT. Trophozoites that are left over from cell division can go on to form gametocytes.Streptococcal Vaccines: Vaccines or candidate vaccines used to prevent STREPTOCOCCAL INFECTIONS.Fluoroacetates: Derivatives of acetic acid with one or more fluorines attached. They are almost odorless, difficult to detect chemically, and very stable. The acid itself, as well as the derivatives that are broken down in the body to the acid, are highly toxic substances, behaving as convulsant poisons with a delayed action. (From Miall's Dictionary of Chemistry, 5th ed)Anthrax Vaccines: Vaccines or candidate vaccines used to prevent ANTHRAX.Dengue Vaccines: Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Vaccines, Virosome: Vaccines using VIROSOMES as the antigen delivery system that stimulates the desired immune response.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Viral Hepatitis Vaccines: Any vaccine raised against any virus or viral derivative that causes hepatitis.Poliovirus Vaccine, Oral: A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)Yellow Fever Vaccine: Vaccine used to prevent YELLOW FEVER. It consists of a live attenuated 17D strain of the YELLOW FEVER VIRUS.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Plague Vaccine: A suspension of killed Yersinia pestis used for immunizing people in enzootic plague areas.Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)Genome, Protozoan: The complete genetic complement contained in a set of CHROMOSOMES in a protozoan.Anopheles: A genus of mosquitoes (CULICIDAE) that are known vectors of MALARIA.Fungal Vaccines: Suspensions of attenuated or killed fungi administered for the prevention or treatment of infectious fungal disease.Host-Parasite Interactions: The relationship between an invertebrate and another organism (the host), one of which lives at the expense of the other. Traditionally excluded from definition of parasites are pathogenic BACTERIA; FUNGI; VIRUSES; and PLANTS; though they may live parasitically.Poxviridae: A family of double-stranded DNA viruses infecting mammals (including humans), birds and insects. There are two subfamilies: CHORDOPOXVIRINAE, poxviruses of vertebrates, and ENTOMOPOXVIRINAE, poxviruses of insects.Rubella Vaccine: A live attenuated virus vaccine of duck embryo or human diploid cell tissue culture origin, used for routine immunization of children and for immunization of nonpregnant adolescent and adult females of childbearing age who are unimmunized and do not have serum antibodies to rubella. Children are usually immunized with measles-mumps-rubella combination vaccine. (Dorland, 28th ed)Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.Vaccines, Acellular: Vaccines that are produced by using only the antigenic part of the disease causing organism. They often require a "booster" every few years to maintain their effectiveness.Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.SAIDS Vaccines: Vaccines or candidate vaccines designed to prevent SAIDS; (SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME); and containing inactivated SIMIAN IMMUNODEFICIENCY VIRUS or type D retroviruses or some of their component antigens.Salmonella Vaccines: Vaccines or candidate vaccines used to prevent infection with SALMONELLA. This includes vaccines used to prevent TYPHOID FEVER or PARATYPHOID FEVER; (TYPHOID-PARATYPHOID VACCINES), and vaccines used to prevent nontyphoid salmonellosis.Vaccines, Virus-Like Particle: Vaccines using supra-molecular structures composed of multiple copies of recombinantly expressed viral structural proteins. They are often antigentically indistinguishable from the virus from which they were derived.Ebola Vaccines: Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.Culicidae: A family of the order DIPTERA that comprises the mosquitoes. The larval stages are aquatic, and the adults can be recognized by the characteristic WINGS, ANIMAL venation, the scales along the wing veins, and the long proboscis. Many species are of particular medical importance.Influenza, Human: An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.Interferon-gamma: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Staphylococcal VaccinesDiphtheria-Tetanus-acellular Pertussis Vaccines: Combined vaccines consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and an acellular form of PERTUSSIS VACCINE. At least five different purified antigens of B. pertussis have been used in various combinations in these vaccines.Cytomegalovirus Vaccines: Vaccines or candidate vaccines used to prevent infection with CYTOMEGALOVIRUS.Mice, Inbred C57BLImmunization Programs: Organized services to administer immunization procedures in the prevention of various diseases. The programs are made available over a wide range of sites: schools, hospitals, public health agencies, voluntary health agencies, etc. They are administered to an equally wide range of population groups or on various administrative levels: community, municipal, state, national, international.Injections, Intramuscular: Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Diphtheria-Tetanus Vaccine: A combined vaccine used to prevent infection with diphtheria and tetanus toxoid. This is used in place of DTP vaccine (DIPHTHERIA-TETANUS-PERTUSSIS VACCINE) when PERTUSSIS VACCINE is contraindicated.Poliovirus Vaccines: Vaccines used to prevent POLIOMYELITIS. They include inactivated (POLIOVIRUS VACCINE, INACTIVATED) and oral vaccines (POLIOVIRUS VACCINE, ORAL).Administration, Intranasal: Delivery of medications through the nasal mucosa.Escherichia coli Vaccines: Vaccines or candidate vaccines used to prevent or treat both enterotoxigenic and enteropathogenic Escherichia coli infections.West Nile Virus Vaccines: Vaccines or candidate vaccines used to prevent infection with WEST NILE VIRUS.DNA, Protozoan: Deoxyribonucleic acid that makes up the genetic material of protozoa.Parasitic Sensitivity Tests: Tests that demonstrate the relative effectiveness of chemotherapeutic agents against specific parasites.Hemagglutination Inhibition Tests: Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.Shigella Vaccines: Vaccines or candidate vaccines used to prevent bacillary dysentery (DYSENTERY, BACILLARY) caused by species of SHIGELLA.Neutralization Tests: The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth CareGeographicals
Malaria VaccinesPlasmodium falciparumMalaria, FalciparumSporozoitesAntigens, ProtozoanVaccinesVaccines, InactivatedViral VaccinesVaccines, SyntheticVaccines, CombinedVaccines, DNAProtozoan ProteinsBacterial VaccinesLife Cycle StagesMalariaPlasmodium yoeliiAIDS VaccinesPlasmodium bergheiAntibodies, ProtozoanMerozoitesVaccines, SubunitVaccines, ConjugateVaccinationPlasmodiumMerozoite Surface Protein 1Plasmodium chabaudiSchizontsPapillomavirus VaccinesErythrocytesParasitemiaMeningococcal VaccinesPlasmodium vivaxHepatitis B VaccinesParasitesReproduction, AsexualMeasles VaccinePertussis VaccineAluminum HydroxideHaemophilus VaccinesBCG VaccineAdjuvants, ImmunologicPoliovirus Vaccine, InactivatedRabies VaccinesEosine I BluishAntimalarialsRotavirus VaccinesImmunizationMaliCholera VaccinesMalaria, VivaxOocystsMice, Inbred BALB CGenes, ProtozoanImmunoglobulin GTyphoid-Paratyphoid VaccinesSmallpox VaccineTuberculosis VaccinesAntibodies, ViralPlasmodium knowlesiChickenpox VaccineDiphtheria-Tetanus-Pertussis VaccineMumps VaccineHepatitis A VaccinesImmunization ScheduleImmunization, SecondaryMeasles-Mumps-Rubella VaccineSaimiriTrophozoitesStreptococcal VaccinesFluoroacetatesAnthrax VaccinesDengue VaccinesMolecular Sequence DataVaccines, VirosomeEnzyme-Linked Immunosorbent AssayAmino Acid SequenceViral Hepatitis VaccinesPoliovirus Vaccine, OralYellow Fever VaccineAntibodies, BacterialPlague VaccinePrimaquineGenome, ProtozoanAnophelesFungal VaccinesHost-Parasite InteractionsPoxviridaeRubella VaccineChloroquineVaccines, AcellularCross ReactionsSAIDS VaccinesSalmonella VaccinesVaccines, Virus-Like ParticleEbola VaccinesCulicidaeInfluenza, HumanInterferon-gammaAntibodies, NeutralizingStaphylococcal VaccinesDiphtheria-Tetanus-acellular Pertussis VaccinesCytomegalovirus VaccinesMice, Inbred C57BLImmunization ProgramsInjections, IntramuscularAntigens, SurfaceDiphtheria-Tetanus VaccinePoliovirus VaccinesAdministration, IntranasalEscherichia coli VaccinesWest Nile Virus VaccinesDNA, ProtozoanParasitic Sensitivity TestsHemagglutination Inhibition TestsShigella VaccinesNeutralization TestsAntibody Formation
Feeder of liceFeeder of lice
Initially the lice were grown on the blood of guinea pigs but the effectiveness of the vaccine depended on the blood being as ... At that point the infected louse had to be fed human blood for about five more days. This stage of the production process ... The development of the typhus vaccine involved several stages. First, the lice larvae had to be bred and then fed on human ... and it was still difficult to produce the vaccine on a large scale. At the time Weigl's vaccine was the only one in existence ...
Duck plagueDuck plague
If host organisms survive primary infection, they enter a latent stage lasting up to 4 years. Latent stage leads to vertical ... Only attenuated vaccines are efficacious. Once DVE is present, depopulation, relocation and intensive disinfection are required ... and blood lymphocytes. The latency sites of APV-1 is similar to other herpesviruses. Vaccination for duck viral enteritis is ...
Baxter InternationalBaxter International
Feldman, EA; Bayer R (1999). Blood feuds: AIDS, blood, and the politics of medical disaster. Oxford University Press. pp. 49-50 ... In July 2014, Baxter announced that it was exiting the vaccines business-divesting its commercial vaccine portfolio to Pfizer ( ... and products to treat end-stage renal disease, or irreversible kidney failure, including products for peritoneal dialysis and ... "Contaminant Found in Blood Thinner", Washington Post (Online edition), March 5, 2008 "Baxter probe focuses on US-owned China ...
African Malaria Network TrustAfrican Malaria Network Trust
"Safety of Recombinant Hybrid GMZ 2 [GLURP + MSP 3] Blood Stage Malaria Vaccine". ClinicalTrial.gov. Retrieved 2008-02-10. " ... Other candidate vaccines which meet the required profile are welcome to the AMANET malaria vaccine development programme. Human ... Vaccines have been exceptionally effective against a number of diseases and have become one of the safest and most cost- ... The vaccine is currently undergoing testing for safety in children both in Burkina Faso and shortly in Tanzania. Should the ...
Yellow feverYellow fever
To confirm a suspected case, blood sample testing with polymerase chain reaction is required. A safe and effective vaccine ... The disease may be difficult to tell apart from other illnesses, especially in the early stages. ... Following this, two vaccines were developed in the 1930s. The vaccine 17D was developed by the South African microbiologist Max ... Since this vaccine was associated with a higher incidence of encephalitis, FNV was not recommended after 1961. Vaccine 17D is ...
RTS,SRTS,S
Other vaccine candidates, targeting the blood-stage of the malaria parasite's life cycle, have also been insufficient on their ... "Vaccines for preventing malaria (blood-stage)". Cochrane Database of Systematic Reviews (4): CD006199. doi:10.1002/14651858. ... Among several potential vaccines under development that target the pre-erythrocytic stage of the disease, RTS,S has shown the ... 2005). "Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army ...
Mycobacterium avium subspecies paratuberculosisMycobacterium avium subspecies paratuberculosis
Stage 1 human trials began in January 2017. He is also developing a companion MAP blood test. ... Professor John Hermon-Taylor of Kings College London is developing a new vector type anti MAP vaccine which he claims is both ... Recently, John Aitken and Otakaro Pathways have discovered a method to culture MAP from human blood. Testing is ongoing. ... It is heat resistant and is capable of sequestering itself inside white blood cells, which may contribute to its persistence in ...
Yellow feverYellow fever
... especially in the early stages.[3] To confirm a suspected case, blood-sample testing with polymerase chain reaction is required ... Since this vaccine was associated with a higher incidence of encephalitis, FNV was not recommended after 1961. Vaccine 17D is ... Little research has been done to develop new vaccines. Some researchers worry that the 60-year-old technology for vaccine ... Vaccine 2017;35(43):5751-52. doi: 10.1016/j.vaccine.2017.06.087 [published Online First: 2017/07/12] ...
Ehrlichia ruminantiumEhrlichia ruminantium
A live blood vaccine is available for protection of young stock, but animals may require treatment for the disease post- ... During the early stages of disease animals may be treated with sulfonamides and tetracyclines. In advanced disease, prognosis ...
AmoebozoaAmoebozoa
Increased white blood cell count is present in severe cases, but not in mild ones. The most accurate test is for antibodies in ... There is no vaccine. There are two treatment options depending on the location of the infection. Amoebiasis in tissues is ... For treatment to be effective against all stages of the amoeba may require a combination of medications. Infections without ... People affected may develop anemia due to loss of blood. Invasion of the intestinal lining causes amoebic bloody diarrhea or ...
AmoebiasisAmoebiasis
Symptoms can range from mild diarrhea to severe dysentery with blood and mucus. The blood comes from lesions formed by the ... There is no vaccine. There are two treatment options depending on the location of the infection. Amoebiasis in tissues is ... Effective treatment against all stages of the disease may require a combination of medications. Infections without symptoms do ... People affected may develop anemia due to loss of blood. Cysts of Entamoeba can survive for up to a month in soil or for up to ...
HybriCellHybriCell
Barbuto, predicted that the vaccine would be even more effective in patients in earlier stages of cancer. The vaccine is ... To create the vaccine, blood is drawn from the patient and monocytes specific to the patient are separated from the blood via ... The vaccine works by extracting certain leukocytes from the patient's blood and merging them with cancer cells, enabling the ... Each vaccine is specific to that patient. Though not a preventative measure, the vaccine's creator, Dr. ...
Chagas diseaseChagas disease
Other preventive efforts include screening blood used for transfusions.[1] A vaccine has not been developed as of 2017.[1] ... The human disease occurs in two stages: an acute stage, which occurs shortly after an initial infection, and a chronic stage ... Screening of donated blood, blood components, and solid organ donors, as well as donors of cells, tissues, and cell and tissue ... T. cruzi can also be transmitted through blood transfusions. With the exception of blood derivatives (such as fractionated ...
Chetan Eknath ChitnisChetan Eknath Chitnis
Furthermore, his research group is involved in the studies of molecular signaling during the blood stage of Plasmodium ... He is the head of the Malaria Parasite Biology and Vaccines Unit at the Institut Pasteur in Paris and an elected fellow of the ... and widened the understanding of the parasite-binding proteins and their interactions with the Duffy blood group antigen of the ... At ICGEB, he has also established a protein production facility for the production of malaria vaccines based on novel concepts ...
Enterotoxigenic Escherichia coliEnterotoxigenic Escherichia coli
To date, no licensed vaccines specifically target ETEC, though several are in various stages of development. Studies indicate ... watery diarrhea with no blood or leukocytes and abdominal cramping. Fever, nausea with or without vomiting, chills, loss of ... Vaccine. 34 (26): 2880-2886. doi:10.1016/j.vaccine.2016.02.076. PMID 26988259. US Centers for Disease Control and Prevention ( ... Vaccine. 24 (15): 2732-2750. doi:10.1016/j.vaccine.2005.10.014. PMID 16483695. PATH, bvgh (March 2011). "The Case for ...
Robert W. McCollumRobert W. McCollum
This discovery set the stage for the development of the polio vaccine. McCollum was a captain in the United States Army Medical ... McCollum found increased hepatitis risk in using the blood of paid donors. Other research isolated Epstein-Barr virus as one of ... Dorothy M. Horstmann, McCollum isolated poliovirus in blood samples taken from those afflicted with the disease and from their ... where they found that a form of hepatitis was spread through blood transfusions and that transmission of serum hepatitis (now ...
Chiron CorporationChiron Corporation
... and blood testing. Chiron's vaccines and blood testing units were combined to form Novartis Vaccines and Diagnostics, while ... which detects viral RNA and DNA in donated blood and plasma during the very early stages of infection, when those infectious ... Having launched its first vaccine product, Fluad, an adjuvant influenza vaccine, in 1996, the vaccine line was expanded ... the UK-based vaccines company, making Chiron the second-largest flu vaccines provider and the fifth-largest vaccines business ...
Ticks of domestic animalsTicks of domestic animals
... followed by splenectomy to produce many of the piroplasm stage in blood, which is then bottled for use. The vaccine is ... The larva does not feed, but directly molts into the first nymph stage. This stage feeds then molts into the next nymph stage. ... This vaccine is manufactured in Australia and a closely similar vaccine is manufactured in Cuba. Walker, M.D. (2017) Ticks on ... The female takes repeated blood meals that are small compared to a female hard tick. Each blood meal is converted to a small ...
ImugeneImugene
... particularly those at an earlier stage of disease. The delivery system helps adjuvant the vaccine, increasing the size of the ... Also in vitro, blood from the patients carried markers of a cellular immune response such as IL-2, IFN-γ and TNF-α (meaning ... The vaccine's developers argue that HER-Vaxx has a number of benefits over the anti-HER2 monoclonal antibodies. The vaccine ... Early-stage funding was secured from Australian and US investors in 2013, after which Biolife was taken public in December 2013 ...
Ursula WiedermannUrsula Wiedermann
This vaccine is currently being taken into mid-stage clinical development in gastric cancer by the biotech company Imugene, ... Also in vitro, blood from the patients carried markers of a cellular immune response such as IL-2, IFN-γ and TNF-α (meaning ... Vaccine. 29 (10): 1981-90. doi:10.1016/j.vaccine.2010.12.101. PMID 21216308. Hoflehner E; Hufnagl K; Schabussova I; Jasinska J ... Early-stage funding was secured from Australian and US investors in 2013, after which Biolife was taken public in December 2013 ...
HIV/AIDSHIV/AIDS
... of blood. May include generalized lymph node enlargement. Stage II: Mild symptoms which may include minor mucocutaneous ... Currently, there is no licensed vaccine for HIV or AIDS. The most effective vaccine trial to date, RV 144, was published in ... The second most frequent mode of HIV transmission is via blood and blood products. Blood-borne transmission can be through ... of blood transfusions using infected blood. In developed countries the risk of acquiring HIV from a blood transfusion is ...
ChikungunyaChikungunya
Vaccine[edit]. As of 2017[update], no approved vaccines are available. A phase-II vaccine trial used a live, attenuated virus, ... two stages have been identified: a viral stage during the first five to seven days, during which viremia occurs,[12] followed ... "Blood Transfusion = Trasfusione del Sangue. 6 (4): 199-210. doi:10.2450/2008.0016-08. PMC 2626913. PMID 19112735.. ... "Vaccine. 29 (16): 3067-73. doi:10.1016/j.vaccine.2011.01.076. PMC 3081687. PMID 21300099.. ...
Malaria prophylaxisMalaria prophylaxis
Causal prophylactics target not only the blood stages of malaria, but the initial liver stage as well. This means that the user ... Vaccine. 28 (31): 4880-4894. doi:10.1016/j.vaccine.2010.05.033. PMID 20553771. Stein, R. Experimental malaria vaccine protects ... This means that they are only effective at killing the malaria parasite once it has entered the erythrocytic stage (blood stage ... Once the malaria parasite enters the erythorocytic stage, it can adversely affect blood cells, making it possible to contract ...
DNA vaccinationDNA vaccination
Rhesus monkeys were primed with a multicomponent, multistage DNA vaccine encoding two liver-stage antigens - the ... and two blood stage antigens - the apical merozoite surface protein 1 (PkAMA1) and merozoite surface protein 1 (PkMSP1p42). ... Second generation vaccines were developed to reduce the risks from live vaccines. These are subunit vaccines, consisting of ... First generation vaccines are whole-organism vaccines - either live and weakened, or killed forms. Live, attenuated vaccines, ...
Index of oncology articlesIndex of oncology articles
... white blood cell - Whitmore-Jewett staging system - whole cell vaccine - Wilms' tumor - Wobe-Mugos E x-ray - x-ray therapy - ... blood cell count - blood chemistry study - blood thinner - blood transfusion - blood-brain barrier - blood-brain barrier ... uvula vaccine adjuvant - vaccine therapy - vaccinia CEA vaccine - valacyclovir - valdecoxib - valerian - Valeriana officinalis ... urea nitrogen-see blood urea nitrogen - ureteroscopy - urine cytology-see urine - urokinase - urologic oncologist-see urology ...
EbolaEbola
Vaccines. Main article: Ebola vaccine. An Ebola vaccine, rVSV-ZEBOV, was approved in the United States in December 2019.[8] It ... This may cause vomiting blood, coughing up of blood, or blood in stool.[32] Bleeding into the skin may create petechiae, ... Symptoms usually begin with a sudden influenza-like stage characterised by feeling tired, fever, weakness, decreased appetite, ... Blood products such as packed red blood cells, platelets, or fresh frozen plasma may also be used.[135] Other regulators of ...
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth CareGeographicals
Malaria VaccinesPlasmodium falciparumMalaria, FalciparumSporozoitesAntigens, ProtozoanVaccinesVaccines, InactivatedViral VaccinesVaccines, SyntheticVaccines, CombinedVaccines, DNAProtozoan ProteinsBacterial VaccinesLife Cycle StagesMalariaPlasmodium yoeliiAIDS VaccinesPlasmodium bergheiAntibodies, ProtozoanMerozoitesVaccines, SubunitVaccines, ConjugateVaccinationPlasmodiumMerozoite Surface Protein 1Plasmodium chabaudiSchizontsPapillomavirus VaccinesErythrocytesParasitemiaMeningococcal VaccinesPlasmodium vivaxHepatitis B VaccinesParasitesReproduction, AsexualMeasles VaccinePertussis VaccineAluminum HydroxideHaemophilus VaccinesBCG VaccineAdjuvants, ImmunologicPoliovirus Vaccine, InactivatedRabies VaccinesEosine I BluishAntimalarialsRotavirus VaccinesImmunizationMaliCholera VaccinesMalaria, VivaxOocystsMice, Inbred BALB CGenes, ProtozoanImmunoglobulin GTyphoid-Paratyphoid VaccinesSmallpox VaccineTuberculosis VaccinesAntibodies, ViralPlasmodium knowlesiChickenpox VaccineDiphtheria-Tetanus-Pertussis VaccineMumps VaccineHepatitis A VaccinesImmunization ScheduleImmunization, SecondaryMeasles-Mumps-Rubella VaccineSaimiriTrophozoitesStreptococcal VaccinesFluoroacetatesAnthrax VaccinesDengue VaccinesMolecular Sequence DataVaccines, VirosomeEnzyme-Linked Immunosorbent AssayAmino Acid SequenceViral Hepatitis VaccinesPoliovirus Vaccine, OralYellow Fever VaccineAntibodies, BacterialPlague VaccinePrimaquineGenome, ProtozoanAnophelesFungal VaccinesHost-Parasite InteractionsPoxviridaeRubella VaccineChloroquineVaccines, AcellularCross ReactionsSAIDS VaccinesSalmonella VaccinesVaccines, Virus-Like ParticleEbola VaccinesCulicidaeInfluenza, HumanInterferon-gammaAntibodies, NeutralizingStaphylococcal VaccinesDiphtheria-Tetanus-acellular Pertussis VaccinesCytomegalovirus VaccinesMice, Inbred C57BLImmunization ProgramsInjections, IntramuscularAntigens, SurfaceDiphtheria-Tetanus VaccinePoliovirus VaccinesAdministration, IntranasalEscherichia coli VaccinesWest Nile Virus VaccinesDNA, ProtozoanParasitic Sensitivity TestsHemagglutination Inhibition TestsShigella VaccinesNeutralization TestsAntibody Formation
Plasmodium berghei - definition of Plasmodium berghei by The Free DictionaryPlasmodium berghei - definition of Plasmodium berghei by The Free Dictionary
1. (Biology) an amoeboid mass of protoplasm, containing many nuclei: a stage in the life cycle of certain organisms, esp the ... Plasmodium berghei ANKA parasites maintained through serial blood passage in mice were used to assess in vivo antimalarial ... New developments in antiprotozoal vaccines/ Gelismekte olan antiprotozoal asilar. Subcutaneous triclosan administered to mice ... 1. an ameboid, multinucleate mass or sheet of cytoplasm characteristic of some stages of organisms, as of slime molds. ...
thefreedictionary.com
Safety of Recombinant Hybrid GMZ 2 [GLURP + MSP 3] Blood Stage Malaria Vaccine - No Study Results Posted - ClinicalTrials.govSafety of Recombinant Hybrid GMZ 2 [GLURP + MSP 3] Blood Stage Malaria Vaccine - No Study Results Posted - ClinicalTrials.gov
Safety of Recombinant Hybrid GMZ 2 [GLURP + MSP 3] Blood Stage Malaria Vaccine. The recruitment status of this study is unknown ...
clinicaltrials.gov
New antigens for a multicomponent blood-stage malaria vaccine | Science Translational MedicineNew antigens for a multicomponent blood-stage malaria vaccine | Science Translational Medicine
Uncharacterized proteins from the merozoite stage of Plasmodium falciparum provide new antigens for malaria blood-stage vaccine ... Uncharacterized proteins from the merozoite stage of Plasmodium falciparum provide new antigens for malaria blood-stage vaccine ... The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody. Nat. Commun. 2, ... An effective blood-stage vaccine against Plasmodium falciparum remains a research priority, but the number of antigens that ...
stm.sciencemag.org
Frontiers | Immunization with the Malaria Diversity-Covering Blood-Stage Vaccine Candidate Plasmodium falciparum Apical...Frontiers | Immunization with the Malaria Diversity-Covering Blood-Stage Vaccine Candidate Plasmodium falciparum Apical...
Several strategies have been developed to improve the cross-strain coverage of PfAMA1-based vaccines, whereas innovative ... Several strategies have been developed to improve the cross-strain coverage of PfAMA1-based vaccines, whereas innovative ... The blood-stage malaria vaccine candidate Plasmodium falciparum apical membrane antigen 1 (PfAMA1) can induce strong parasite ... The blood-stage malaria vaccine candidate Plasmodium falciparum apical membrane antigen 1 (PfAMA1) can induce strong parasite ...
frontiersin.org
Development of a new RH5 VLP vaccine for blood-stage P. falciparum malaria | PATHs Malaria Vaccine InitiativeDevelopment of a new RH5 VLP vaccine for blood-stage P. falciparum malaria | PATH's Malaria Vaccine Initiative
Development of a new RH5 VLP vaccine for blood-stage P. falciparum malaria ... High, sustained levels of the antibody immunoglobulin G (IgG) are key to the development of an effective blood-stage vaccine. ... Development of a new RH5 VLP vaccine for blood-stage P. falciparum malaria ... These IgG levels are necessary for neutralizing the invasion of red blood cells by merozoites, which continues to be a critical ...
malariavaccine.org
Phase Ia Clinical Evaluation of the Plasmodium Falciparum Blood-Stage Antigen MSP1 in ChAd63 and MVA Vaccine VectorsPhase Ia Clinical Evaluation of the Plasmodium Falciparum Blood-Stage Antigen MSP1 in ChAd63 and MVA Vaccine Vectors
Efficacy trials of antibody-inducing protein-in-adjuvant vaccines targeting the blood-stage Plasmodium falciparum malaria ... Phase Ia Clinical Evaluation of the Plasmodium Falciparum Blood-Stage Antigen MSP1 in ChAd63 and MVA Vaccine Vectors Mol Ther. ... Efficacy trials of antibody-inducing protein-in-adjuvant vaccines targeting the blood-stage Plasmodium falciparum malaria ... Further studies are required to assess whether this strategy can achieve protective efficacy against blood-stage malaria ...
pubmed.ncbi.nlm.nih.gov
Phase 1b Randomized Trial and Follow-Up Study in Uganda of the Blood-Stage Malaria Vaccine Candidate BK-SE36Phase 1b Randomized Trial and Follow-Up Study in Uganda of the Blood-Stage Malaria Vaccine Candidate BK-SE36
... is a blood-stage malaria vaccine candidate that has undergone phase 1a trial in malaria-naive Japanese adults. We have now ... Methods We performed a two-stage, randomized, single-blinded, placebo-controlled phase 1b trial (Current Controlled trials ... Background Up to now a malaria vaccine remains elusive. The Plasmodium falciparum serine repeat antigen-5 formulated with ...
journals.plos.org
Phase 1 Study of the Safety, Reactogenicity, and Immunogenicity of AMA1-C1/ISA 720: Blood Stage Vaccine for Plasmodium...Phase 1 Study of the Safety, Reactogenicity, and Immunogenicity of AMA1-C1/ISA 720: Blood Stage Vaccine for Plasmodium...
Malaria is a serious infection of red blood cells caused by a par ... study will evaluate the safety and effectiveness of a vaccine ... A Blood Stage Vaccine for Plasmodium Falciparum. AMA1-C1 with Montanide ISA 720, is a blood stage malaria vaccine candidate. ... Phase 1 Study of the Safety, Reactogenicity and Immunogenicity of AMA1-C1/ISA 720: A Blood Stage Vaccine for Plasmodium ... Receipt of blood products within the past 6 months.. 20. Previous receipt of an investigational malaria vaccine.. 21. History ...
knowcancer.com
Phase 1 Clinical Trial of Apical Membrane Antigen 1: an Asexual Blood-Stage Vaccine for Plasmodium falciparum Malaria |...Phase 1 Clinical Trial of Apical Membrane Antigen 1: an Asexual Blood-Stage Vaccine for Plasmodium falciparum Malaria |...
The acceptable safety profile of the AMA1-C1 vaccine is encouraging, and further development of this blood-stage vaccine in ... Phase 1 Clinical Trial of Apical Membrane Antigen 1: an Asexual Blood-Stage Vaccine for Plasmodium falciparum Malaria. Elissa M ... The results of this trial demonstrate that the AMA1-C1 blood-stage malaria vaccine is safe when administered to adult malaria- ... Antigens expressed during the blood stage of P. falciparum infection are attractive targets for malaria vaccine development ...
iai.asm.org
New Candidate Vaccines against Blood-Stage Plasmodium falciparum Malaria: Prime-Boost Immunization Regimens Incorporating Human...New Candidate Vaccines against Blood-Stage Plasmodium falciparum Malaria: Prime-Boost Immunization Regimens Incorporating Human...
New Candidate Vaccines against Blood-Stage Plasmodium falciparum Malaria: Prime-Boost Immunization Regimens Incorporating Human ... New Candidate Vaccines against Blood-Stage Plasmodium falciparum Malaria: Prime-Boost Immunization Regimens Incorporating Human ... New Candidate Vaccines against Blood-Stage Plasmodium falciparum Malaria: Prime-Boost Immunization Regimens Incorporating Human ... New Candidate Vaccines against Blood-Stage Plasmodium falciparum Malaria: Prime-Boost Immunization Regimens Incorporating Human ...
iai.asm.org
Effect of the Pre-erythrocytic Candidate Malaria Vaccine RTS,S/AS01E on Blood Stage Immunity in Young Children - MORU Tropical...Effect of the Pre-erythrocytic Candidate Malaria Vaccine RTS,S/AS01E on Blood Stage Immunity in Young Children - MORU Tropical...
Effect of the Pre-erythrocytic Candidate Malaria Vaccine RTS,S/AS01E on Blood Stage Immunity in Young Children ... Effect of the Pre-erythrocytic Candidate Malaria Vaccine RTS,S/AS01E on Blood Stage Immunity in Young Children ...
tropmedres.ac
Discovery of GAMA, a Plasmodium falciparum Merozoite Micronemal Protein, as a Novel Blood-Stage Vaccine Candidate AntigenDiscovery of GAMA, a Plasmodium falciparum Merozoite Micronemal Protein, as a Novel Blood-Stage Vaccine Candidate Antigen
... ... 584742-discovery-of-gama--a-plasmodium-falciparum-merozoite-micronemal-protein--as-a-novel-blood-stage-vaccine-candidate- ... and the GIA Reference Center is supported by the PATH/Malaria Vaccine Initiative. ...
findanexpert.unimelb.edu.au
Can a century-old TB vaccine steel the immune system against the new coronavirus? | Science | AAASCan a century-old TB vaccine steel the immune system against the new coronavirus? | Science | AAAS
... a vaccine made of living bacteria, to protect health care workers at risk of COVID-19 infection ... Blood test could identify early stage Alzheimers disease By Charlotte Hartley. Jul. 29, 2020. ... Vaccines are based on this mechanism of immunity.. The innate immune system, composed of white blood cells such as macrophages ... Can a century-old TB vaccine steel the immune system against the new coronavirus?. By Jop de Vrieze. Mar. 23, 2020 , 6:25 AM. ...
sciencemag.org
Immuno-epidemiological epitope mapping of a blood stage malaria vaccine antigen - Christopher PloweImmuno-epidemiological epitope mapping of a blood stage malaria vaccine antigen - Christopher Plowe
An effective blood stage Plasmodium falciparum malaria vaccine would be of immense global health benefit, particularly for ... Immuno-epidemiological epitope mapping of a blood stage malaria vaccine antigen Plowe, Christopher V. University of Maryland ... An effective blood stage Plasmodium falciparum malaria vaccine would be of immense global health benefit, particularly for ... Immuno-epidemiological epitope mapping of a blood stage malaria vaccine antigen. Plowe, Christopher V. / University of Maryland ...
grantome.com
Functional comparison of blood-stage Plasmodium falciparum malaria vaccine candidate antigens - ResearchOnline@JCUFunctional comparison of blood-stage Plasmodium falciparum malaria vaccine candidate antigens - [email protected]
RH5 is one of the leading blood-stage Plasmodium falciparum malaria vaccine antigens and Phase I/II clinical trials of vaccines ... malaria, vaccine, blood-stage malaria, antigen, me rozoite, RH5, S-antigen, AARP. ... Functional comparison of blood-stage Plasmodium falciparum malaria vaccine candidate antigens. Frontiers in Immunology, 10. ... The objective of this study was to compare a range of blood-stage antigens to RH5, to identify any antigens that outperform or ...
researchonline.jcu.edu.au
HER2-targeted dendritic cell vaccine shows promise for treating early-stage breast cancer patientsHER2-targeted dendritic cell vaccine shows promise for treating early-stage breast cancer patients
The dendritic cell vaccines were prepared by isolating dendritic cells from each patients blood and exposing them to fragments ... HER2-targeted dendritic cell vaccine shows promise for treating early-stage breast cancer patients. *Download PDF Copy ... Tags: Blood, Breast Cancer, Cancer, Carcinoma, Cell, Clinical Trial, Dendritic Cell, Ductal Carcinoma, Ductal Carcinoma in Situ ... Creating a blood test for the detection of Alzheimers disease. Dr. Randall Bateman and Dr. Nicolas Barthélemy ...
news-medical.net
Malaria 2012: Drugs, Vaccines, and Pathogenesis | The New York Academy of SciencesMalaria 2012: Drugs, Vaccines, and Pathogenesis | The New York Academy of Sciences
... with effective vaccines in clinical trials and candidate drugs to address resistance under development. This eBriefing examines ... Improving the recipe for a high efficacy, blood-stage malaria vaccine. Disease symptoms occur only during the blood stage of ... So vaccines that target the blood stage parasite are considered to be anti-disease vaccines that are meant to prevent or reduce ... By identifying immune correlates of blood-stage vaccine protection, Plowes team is now trying to understand how the vaccine ...
nyas.org
Researchers develop blood test to detect cancer at early stage | FOX31 DenverResearchers develop blood test to detect cancer at early stage | FOX31 Denver
Scientists at Stage 1 Diagnostics developed the test that is said to be simple and cost-effective, KHTV reports. ... Researchers in Arkansas say they have developed a blood test that can help detect cancer at an early stage. ... Stanford researchers say cancer vaccine eliminated tumors in mice. * Health. Study: Hot tea linked to cancer in people who ... Researchers develop blood test to detect cancer at early stage. Posted 7:39 am, March 5, 2018, by Web Staff ...
kdvr.com
Like Hand-Washing, Blood Transfusions Linked to Infections | URMC NewsroomLike Hand-Washing, Blood Transfusions Linked to Infections | URMC Newsroom
Doing fewer blood transfusions reduces infection rates by nearly 20 percent, according to a study in the Journal of the ... URMC, RRH Join Pfizer and BioNTech Late-Stage COVID-19 Vaccine Study ... Doing fewer blood transfusions reduces infection rates by nearly 20 percent, according to a study in the Journal of the ... As director of transfusion medicine and the blood bank at UR Medicine, Blumberg for more than 25 years has been investigating ...
urmc.rochester.edu
New antigens for a multicomponent blood-stage malaria vaccine - Centre for Tropical Medicine and Global HealthNew antigens for a multicomponent blood-stage malaria vaccine - Centre for Tropical Medicine and Global Health
New antigens for a multicomponent blood-stage malaria vaccine Osier FH., Mackinnon MJ., Crosnier C., Fegan G., Kamuyu G., ... Typhoid vaccine over 81% effective in tackling disease in Nepal * Sophie Yacoub nominated Emerging Leader in Infectious ... Malaria parasites present in 23% of donor blood in African countries * Getting rid of malaria possible, if we try something new ... Were developing the worlds first vaccine suitable for humans and livestock * Fever and Antibiotic use, a theatre initiative ...
tropicalmedicine.ox.ac.uk
Oprahs favorite $25 slippers are filled with French lavender: Happy feet for up to an hour!Oprah's favorite $25 slippers are filled with French lavender: 'Happy feet for up to an hour!'
Moderna COVID-19 vaccine enters final stage trial this month. AFP News ...
ph.news.yahoo.com
RTS,S/AS01E immunization increases antibody responses to vaccine-unrelated Plasmodium falciparum antigens associated with...RTS,S/AS01E immunization increases antibody responses to vaccine-unrelated Plasmodium falciparum antigens associated with...
Antibody; Blood-stage antigens; Malaria; Maternal antibodies; Naturally acquired immunity; Plasmodium falciparum; Pre- ... To date, only vaccine-specific immune responses have routinely been investigated in malaria vaccine trials conducted in endemic ... Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Paris, France.. 11. Laboratory of Malaria and Vaccine Research, ... S vaccination increased IgG levels to a specific group of pre-erythrocytic and blood-stage antigens (MSP5, MSP1 block 2, RH4.2 ...
ncbi.nlm.nih.gov
Vaccine Therapy in Treating Patients With Stage D0 Prostate Cancer - Full Text View - ClinicalTrials.govVaccine Therapy in Treating Patients With Stage D0 Prostate Cancer - Full Text View - ClinicalTrials.gov
Blood. 2012 Oct 11;120(15):3030-8. doi: 10.1182/blood-2012-05-427799. Epub 2012 Aug 28. ... Vaccine Therapy in Treating Patients With Stage D0 Prostate Cancer. The safety and scientific validity of this study is the ... To determine whether ONY-P1 vaccine can increase the time to PSA-defined progression in patients with androgen-dependent stage ... Biological: BCG vaccine Biological: prostate cancer vaccine ONY-P1 Other: placebo Phase 2 ...
clinicaltrials.gov
Supplementary Materials | Science Translational MedicineSupplementary Materials | Science Translational Medicine
New antigens for a multicomponent blood-stage malaria vaccine. Faith H. Osier, Margaret J. Mackinnon, Cécile Crosnier, Gregory ...
stm.sciencemag.org
Vaccines against malaria : hope in a gathering storm (eBook, 1996) [WorldCat.org]Vaccines against malaria : hope in a gathering storm (eBook, 1996) [WorldCat.org]
Philip K Russell; Christopher Paul Howson; Institute of Medicine (U.S.). Committee on Malaria Vaccines.;] -- Vaccines Against ... Vaccines against malaria : hope in a gathering storm. [ ... "Asexual Blood-Stage Vaccines""; ""Sexual (Gametocyte) Vaccines ... Malaria vaccine a schema:Intangible ;. schema:name "Malaria vaccine"@en ;. . ... Malaria Vaccines a schema:Intangible ;. schema:name "Malaria Vaccines"@en ;. . ...
worldcat.org
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth CareGeographicals
Malaria VaccinesPlasmodium falciparumMalaria, FalciparumSporozoitesAntigens, ProtozoanVaccinesVaccines, InactivatedViral VaccinesVaccines, SyntheticVaccines, CombinedVaccines, DNAProtozoan ProteinsBacterial VaccinesLife Cycle StagesMalariaPlasmodium yoeliiAIDS VaccinesPlasmodium bergheiAntibodies, ProtozoanMerozoitesVaccines, SubunitVaccines, ConjugateVaccinationPlasmodiumMerozoite Surface Protein 1Plasmodium chabaudiSchizontsPapillomavirus VaccinesErythrocytesParasitemiaMeningococcal VaccinesPlasmodium vivaxHepatitis B VaccinesParasitesReproduction, AsexualMeasles VaccinePertussis VaccineAluminum HydroxideHaemophilus VaccinesBCG VaccineAdjuvants, ImmunologicPoliovirus Vaccine, InactivatedRabies VaccinesEosine I BluishAntimalarialsRotavirus VaccinesImmunizationMaliCholera VaccinesMalaria, VivaxOocystsMice, Inbred BALB CGenes, ProtozoanImmunoglobulin GTyphoid-Paratyphoid VaccinesSmallpox VaccineTuberculosis VaccinesAntibodies, ViralPlasmodium knowlesiChickenpox VaccineDiphtheria-Tetanus-Pertussis VaccineMumps VaccineHepatitis A VaccinesImmunization ScheduleImmunization, SecondaryMeasles-Mumps-Rubella VaccineSaimiriTrophozoitesStreptococcal VaccinesFluoroacetatesAnthrax VaccinesDengue VaccinesMolecular Sequence DataVaccines, VirosomeEnzyme-Linked Immunosorbent AssayAmino Acid SequenceViral Hepatitis VaccinesPoliovirus Vaccine, OralYellow Fever VaccineAntibodies, BacterialPlague VaccinePrimaquineGenome, ProtozoanAnophelesFungal VaccinesHost-Parasite InteractionsPoxviridaeRubella VaccineChloroquineVaccines, AcellularCross ReactionsSAIDS VaccinesSalmonella VaccinesVaccines, Virus-Like ParticleEbola VaccinesCulicidaeInfluenza, HumanInterferon-gammaAntibodies, NeutralizingStaphylococcal VaccinesDiphtheria-Tetanus-acellular Pertussis VaccinesCytomegalovirus VaccinesMice, Inbred C57BLImmunization ProgramsInjections, IntramuscularAntigens, SurfaceDiphtheria-Tetanus VaccinePoliovirus VaccinesAdministration, IntranasalEscherichia coli VaccinesWest Nile Virus VaccinesDNA, ProtozoanParasitic Sensitivity TestsHemagglutination Inhibition TestsShigella VaccinesNeutralization TestsAntibody Formation
PlasmodiumAntigensImmunityFalciparumImmunizationTrialsScientistsPathogenTumorResearchersAsexualScience Translational MedicineTumorsConfersCoronavirusAntibody responsesImmunologyGametocyteSubunitEffectiveness of the vaccineAccess to vaccinesMalaria blood-stagePlaceboMoffitt CancerRational vaccine designResponsesExperimentalImmunogenicityDendritic cellsVaccinateEffectiveInitiativeAMA1-C1AfricaRabiesHuman vaccineCancer vaccinesProtective vaccines
Plasmodium1
Antigens26
Immunity18
Falciparum26
Immunization5
Trials16
Scientists23
Pathogen2
  • They concluded the vaccine prevents about 30% of infections with any known pathogen, including viruses, in the first year after it's given. (sciencemag.org)
  • Studies of pathogen strains that evolve the capacity to replicate and transmit from vaccinated hosts will enhance our ability to develop next-generation vaccines that minimize the risk of harmful pathogen evolution. (pnas.org)
Tumor8
  • Patients were injected with a dose of their personal dendritic cell vaccine once a week for 6 weeks into either a lymph node, the breast tumor, or into both sites. (news-medical.net)
  • RATIONALE: Vaccines made from tumor cells may help the body build an effective immune response to kill tumor cells. (clinicaltrials.gov)
  • The prognosis and survival rate of cervical cancer depends on the stage and type of cervical cancer and tumor size. (medicinenet.com)
  • Hemangiosarcoma is a common soft tissue tumor of the support tissues that surround the blood vessels. (amazonaws.com)
  • Treatment options depends upon the location of the tumor, the extent and the stage to which the cancer has developed. (amazonaws.com)
  • When cancer cells spread to other parts of the body then they pass through several changes like they become able to detach from the original tumor and can attach themselves to the blood vessel walls. (amazonaws.com)
  • Further tests to determine if the vaccine is effective at slowing tumor growth are forthcoming. (medindia.net)
  • Tumor vaccines have historically been developed against a sort of molecular sign-post for cancer. (medindia.net)
Researchers18
Asexual2
Science Translational Medicine1
Tumors3
Confers1
  • Optimism that a first-generation malaria vaccine, RTS,S, may soon be licensed has been tempered by the interim results of an ongoing phase 3 clinical trial in Africa that indicated that the vaccine confers short-lived protection from malaria in only ∼30% of infants ( 2 ). (jimmunol.org)
Coronavirus2
  • Can a century-old TB vaccine steel the immune system against the new coronavirus? (sciencemag.org)
  • In April, with hospitals overwhelmed and much of the United States in lockdown, the Department of Health and Human Services produced a presentation for the White House arguing that rapid development of a coronavirus vaccine was the best hope to control the pandemic. (nytimes.com)
Antibody responses1
  • All mice immunized with the synthetic DNA vaccine developed broad, robust antibody responses against HA and effective cellular immune responses including CD4 and CD8 T cell responses. (medicalxpress.com)
Immunology2
  • We suggest ways in which advances in immunology and genomics-based technology can further improve our understanding of the B cell response in malaria and perhaps illuminate new pathways to the development of effective vaccines. (jimmunol.org)
  • Ward is also affiliated with the International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center and Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID) at Scripps Research. (innovations-report.com)
Gametocyte1
Subunit2
Effectiveness of the vaccine1
  • Initially the lice were grown on the blood of guinea pigs but the effectiveness of the vaccine depended on the blood being as similar to human blood as possible. (wikipedia.org)
Access to vaccines2
  • In contrast, deaths due to vaccine-preventable diseases are almost entirely due to lack of access to vaccines, not vaccine resistance. (pnas.org)
  • It contributes to the eradication of polio and secures the gains made against the disease through stronger immunisation systems, so that all children in all countries have access to vaccines. (healthcanal.com)
Malaria blood-stage1
Placebo4
  • They will recruit 1000 health care workers in eight Dutch hospitals who will either receive the vaccine, called bacillus Calmette-Guérin (BCG), or a placebo. (sciencemag.org)
  • PURPOSE: This randomized phase II trial is studying vaccine therapy to see how well it works compared with a placebo in treating patients with stage D0 prostate cancer. (clinicaltrials.gov)
  • To compare the immunologic response in patients treated with ONY-P1 vaccine vs placebo. (clinicaltrials.gov)
  • Arm II: Patients receive placebo vaccine intradermally on days 1, 15, and 29 and then every 4 weeks for up to 12 months in the absence of disease progression or unacceptable toxicity. (clinicaltrials.gov)
Moffitt Cancer2
  • These results suggest that vaccines are more effective in DCIS, thereby warranting further evaluation in DCIS or other minimal disease settings, and the local regional sentinel lymph node may serve as a more meaningful immunologic endpoint,' said Brian J. Czerniecki, MD, PhD, Chair of the Department of Breast Oncology at Moffitt Cancer Center. (news-medical.net)
  • Barbara Bagby, a former Moffitt Cancer Center nurse, is battling end-stage ovarian cancer. (moffitt.org)
Rational vaccine design1
Responses5
Experimental6
  • Some of these mistakes are huge, such as when a major vaccine manufacturer, Baxter, admitted last year that the company had released a vaccine contaminated with an experimental flu virus. (mercola.com)
  • The big pharmaceutical took its time confirming what the Czechs already knew, but finally admitted that the experimental vaccine was "live. (mercola.com)
  • WASHINGTON (Reuters) - The U.S. National Institutes of Health said on Monday it was abandoning a scheduled trial that would combine two experimental AIDS vaccines in a double punch against the virus, but said a similar trial would go ahead in Thailand. (rense.com)
  • The experimental vaccine should stimulate the immune system to recognize and react to SARS-CoV-2's spike protein, which allows it to enter and infect healthy cells. (medicalnewstoday.com)
  • The vaccine developed by first author, Adam Snook, PhD, Assistant Professor in the Department of Pharmacology and Experimental Therapeutics, Dr. Waldman and others, works by activating the immune system against the GUCY2C molecule. (medindia.net)
  • A team at Scripps Research has come up with a faster way to analyze the outcome of experimental vaccines against HIV and other pathogens. (innovations-report.com)
Immunogenicity4
  • This viral vectored vaccine regime is thus a leading approach for the induction of strong cellular and humoral immunogenicity against difficult disease targets in humans. (nih.gov)
  • The objectives of this phase 1 trial are to study the safety, reactogenicity, and immunogenicity of this vaccine and to assess the level, kinetics, and the in vitro biological activity of the antibody response it induces. (knowcancer.com)
  • A phase 1 trial was conducted with 30 malaria-naïve volunteers to assess the safety and immunogenicity of the AMA1-C1 malaria vaccine. (asm.org)
  • When evaluating the immunogenicity of LiHyS, which is possibly located in the parasite's flagellar pocket, proliferative assays using peripheral blood mononuclear cells from healthy subjects or VL patients showed a high proliferative index in both individuals, when compared to the results obtained using rA2 or unstimulated cultures. (cambridge.org)
Dendritic cells2
Vaccinate1
  • On 24 July 2015, Mosquirix received a positive opinion from the EMA on the proposal of the vaccine to be used to vaccinate children aged 6 weeks to 17 months outside the European Union. (wikipedia.org)
Effective10
Initiative3
  • This study was supported in part by the intramural program of the National Institute of Allergy and Infectious Diseases/NIH, and the GIA Reference Center is supported by the PATH/Malaria Vaccine Initiative. (edu.au)
  • Given that it typically takes years to develop a vaccine , the timetable for the initiative, called Operation Warp Speed , was incredibly ambitious. (nytimes.com)
  • It is funded as part of the budget of the Global Polio Eradication Initiative (GPEI), and support is channelled through Gavi, the Vaccine Alliance, WHO and UNICEF. (healthcanal.com)
AMA1-C11
Africa3
Rabies1
  • We enrolled 400 children aged 12-47 months in general good health.Children were randomised in a 1:1 fashion to receive either FMP1/AS02 (50 µg) or Rabipur® rabies vaccine. (edu.au)
Human vaccine1
Cancer vaccines2
  • Davis calls it "a major milestone for the entire class of therapeutic cancer vaccines in the United States. (healthcanal.com)
  • While it is too early to claim success for therapeutic cancer vaccines, they offer patients and families facing cancer a new ray of hope," concludes Davis. (healthcanal.com)
Protective vaccines1