Blood Protein DisordersBlood Proteins: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.Vitelline Duct: The narrow tube connecting the YOLK SAC with the midgut of the EMBRYO; persistence of all or part of it in post-fetal life produces abnormalities, of which the commonest is MECKEL DIVERTICULUM.Coagulation Protein Disorders: Hemorrhagic and thrombotic disorders resulting from abnormalities or deficiencies of coagulation proteins.Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Hemoglobins: The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Blood Protein Electrophoresis: Electrophoresis applied to BLOOD PROTEINS.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Protein Folding: Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Proteome: The protein complement of an organism coded for by its genome.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.Anxiety Disorders: Persistent and disabling ANXIETY.Mood Disorders: Those disorders that have a disturbance in mood as their predominant feature.Hematologic Diseases: Disorders of the blood and blood forming tissues.Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.Hemoglobin A: Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.Hemoglobins, Abnormal: Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.Fetal Hemoglobin: The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Transplantation, Autologous: Transplantation of an individual's own tissue from one site to another site.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Seasonal Affective Disorder: A syndrome characterized by depressions that recur annually at the same time each year, usually during the winter months. Other symptoms include anxiety, irritability, decreased energy, increased appetite (carbohydrate cravings), increased duration of sleep, and weight gain. SAD (seasonal affective disorder) can be treated by daily exposure to bright artificial lights (PHOTOTHERAPY), during the season of recurrence.Methylation: Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)Affective Disorders, Psychotic: Disorders in which the essential feature is a severe disturbance in mood (depression, anxiety, elation, and excitement) accompanied by psychotic symptoms such as delusions, hallucinations, gross impairment in reality testing, etc.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.DNA Methylation: Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.Mild Cognitive Impairment: A prodromal phase of cognitive decline that may precede the emergence of ALZHEIMER DISEASE and other dementias. It may include impairment of cognition, such as impairments in language, visuospatial awareness, ATTENTION and MEMORY.Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.Twins: Two individuals derived from two FETUSES that were fertilized at or about the same time, developed in the UTERUS simultaneously, and born to the same mother. Twins are either monozygotic (TWINS, MONOZYGOTIC) or dizygotic (TWINS, DIZYGOTIC).Diseases in Twins: Disorders affecting TWINS, one or both, at any age.Cognition Disorders: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Inherited prothrombotic risk factors and cerebral venous thrombosis. (1/102)

Fifteen patients with cerebral venous thrombosis were ascertained retrospectively. Their case notes were reviewed, and stored or new blood was assayed for factor V Leiden (FVL) mutation, prothrombin gene mutation 20201A, and 5,10 methylene tetrahydrofolate reductase (MTHFR) C677T mutation. A clinical risk factor was identified in 13 patients--the oral contraceptive pill (5), puerperium (1), HRT (1), mastoiditis (1), dehydration (1), lumbar puncture and myelography (1), carcinoma (1), lupus anticoagulant (2). In addition, two patients had the FVL mutation and five (one of whom also had the FVL mutation) were homozygous for the MTHFR mutation. The latter showed a higher than expected frequency compared to 300 healthy controls from South Wales (OR 3.15.95% Cl 1.01-9.83). No patient had the prothrombin 20201A mutation. Two patients died and three had a monocular visual deficit following anticoagulation (13) or thrombolytic (2) treatment, but there was no association between the presence of a primary prothrombotic risk factor and outcome. These results confirm the importance of investigating patients for both clinical predisposing factors and primary prothrombotic states.  (+info)

Coordinate augmentation in expression of genes encoding transcription factors and liver secretory proteins in hypo-oncotic states. (2/102)

BACKGROUND: In the nephrotic syndrome (NS) proteins of intermediate size (40 to 200 kD) are lost into the urine resulting in a decrease in plasma albumin concentration and as a consequence a reduction in plasma colloid osmotic pressure (pi). Plasma pi has also been reported to be reduced in the condition of hereditary analbuminemia. The liver, in an apparent compensatory response, increases synthesis of a group of secreted proteins defending plasma pi. Regulation of several of these proteins, including both positive and negative acute phase proteins, is at the transcriptional level. This is the only known condition in which transcription of both positive and negative acute phase proteins (APPs) are increased simultaneously. The specific transcription factor(s) that might regulate this cascade is not defined. METHODS: RNA was extracted from livers of 5 rats with hereditary analbuminemia (the Nagase analbuminemic rat, NAR), 5 rats with NS induced by adriamycin (Adria), 5 rats with NS caused by passive Heymann nephritis (NS) and 5 control animals. The concentrations of mRNAs encoding four secreted proteins (albumin, transferrin, fibrinogen, and apo A-1), five transcription factors, early growth response factor 1 (EGRF-1), HNF-4, NGFI-C, EGR-3, and Krox20 relative to two housekeeping genes, beta actin and GAPDH were determined simultaneously using kinetic reverse transcriptase polymerase chain methodology (kRT-PCR). RESULTS: The levels of all mRNAs encoding secreted proteins except for albumin (which was reduced in NAR) were increased in NS and NAR and correlated significantly with one another. mRNA encoding EGRF 1 was increased fivefold in NS and NAR, and correlated significantly with mRNAs encoding Apo A-1, transferrin and albumin in the two NS groups. HNF-4 mRNA was increased approximately twofold in both NS groups and correlated with albumin (R = 0.881, P < 0.001), transferrin (R = 0.563, P = 0.012) and apo A-1 (R = 0.644, P = 0. 003). While fibrinogen mRNA correlated with that of each of the other secreted proteins, it did not correlate with either HNF-4 or EGRF-1 mRNA. Krox20, EGR3 and NGF1C were expressed at nearly undetectable levels. CONCLUSIONS: The hepatic response in conditions characterized by reduced plasma pi include increased levels of mRNAs encoding a group of secreted proteins, including the negative APPs albumin, transferrin and apo A-1, and the positive APP fibrinogen. Levels of mRNAs encoding negative APPs and fibrinogen correlate with one another, suggesting that they are coordinately controlled. Both EGRF-1 and HNF-4 may regulate the expression of the negative APPs, which have increased transcription in hypo-oncotic states.  (+info)

Complement fixation by rheumatoid factor. (3/102)

The capacity for fixation and activation of hemolytic complement by polyclonal IgM rheumatoid factors (RF) isolated from sera of patients with rheumatoid arthritis and monoclonal IgM-RF isolated from the cryoprecipitates of patients with IgM-IgG mixed cryoglobulinemia was examined. RF mixed with aggregated, reduced, and alkylated human IgG (Agg-R/A-IgG) in the fluid phase failed to significantly reduce the level of total hemolytic complement, CH50, or of individual complement components, C1, C2, C3, and C5. However, sheep erythrocytes (SRC) coated with Agg-R/A-IgG or with reduced and alkylated rabbit IgG anti-SRC antibody were hemolyzed by complement in the presence of polyclonal IgM-RF. Human and guinea pig complement worked equally well. The degree of hemolysis was in direct proportion to the hemagglutination titer of the RF against the same coated cells. Monoclonal IgM-RF, normal human IgM, and purified Waldenstrom macroglobulins without antiglobulin activity were all inert. Hemolysis of coated SRC by RF and complement was inhibited by prior treatment of the complement source with chelating agents, hydrazine, cobra venom factor, specific antisera to C1q, CR, C5, C6, or C8, or by heating at 56 degrees C for 30 min. Purified radiolabeled C4, C3, and C8 included in the complement source were bound to hemolysed SRC in direct proportion to the degree of hemolysis. These data indicate that polyclonal IgM-RF fix and activate complement via the classic pathway. The system described for assessing complement fixation by isolated RF is readily adaptable to use with whole human serum.  (+info)

Sialoproteinaemia: lack of correlation with inhibition of in vitro lymphoblastosis induced by phytohaemagglutinin or alloantigen. (4/102)

Elevation of serum-bound sialic acid concentration in different disease states fails to correlate significantly with suppressive serum actions in mixed allogeneic lymphocyte cultures or phyto-haemagglutinin cultures. Heat-decomplemented serum from patients with abnormal levels of bound sialic acid was added to parallel cultures containing similar blood lymphocyte populations derived from normal humans. Wide fluctuations of the rate of incorporation of tritiated thymidine into nucleoprotein indicated presence of suppressive elements other than sialoprotein in the added serum components. Serum with rising sialyl concentration derived from patients with cancer showed slight tendency to augment mixed lymphocyte and phytohaemagglutinin responses. The findings suggest that the previously documented nonspecific suppressive action of serum sialoprotein on human host lymphoblastic response to neuraminidase-treated cancer cells represents a mechanism unique to that culture system rather than a manifestation of a general immunoregulatory function of serum sialoprotein.  (+info)

Hypoalbuminaemia due to protein loss from gastric carcinoma. (5/102)

In a patient suffering from carcinoma of the stomach generalized oedema was the presenting symptom. It is suggested that this was due to excessive loss of protein from the stomach.  (+info)

STRUCTURAL STUDIES OF HUMAN 7S GAMMA-GLOBULIN (G IMMUNOGLOBULIN). FURTHER OBSERVATIONS OF A NATURALLY OCCURRING PROTEIN RELATED TO THE CRYSTALLIZABLE (FAST) FRAGMENT. (6/102)

1. Detailed physical, chemical, and immunologic studies of a protein closely related to the Fc fragment and heavy chain of G immunoglobulin (IgG), and elaborated by a subject with a lymphoproliferative disorder are presented. 2. The protein, which has a molecular weight of 51,000, was cleaved into two half molecules by reduction and alkylation. 3. The protein has few if any of the antigenic determinants of the antigen-binding (Fab) papain fragment of IgG, and has a striking similarity in its antigenic properties to the Fc fragment. 4. Fingerprint patterns resemble those of the crystallizable (Fc) fragment, and lack several peptides found in the heavy chain. 5. These findings suggest that the Fc fragment may be a real structural unit of IgG, and raise the possibility of the existence of three different types of polypeptide chains in G immunoglobulin.  (+info)

METABOLISM AND FUNCTION OF GAMMA GLOBULIN IN ALEUTIAN DISEASE OF MINK. (7/102)

Aleutian disease-affected mink, which are markedly hypergammaglobulinemic, show a decreased half-life of the serum gamma globulin indicating that the hyperglobulinemia is due to increased production. No evidence that the gamma globulin was antibody to the infectious agent, to autologous or isologous tissues, or to antigens the animal was responding to prior to development of the disease was obtained. The increased gamma globulin was found to be of the 6.4S variety, and gamma globulin containing protein-protein complexes of 9S to 17S and 22S to 25S classes were observed in serums of affected mink. The findings are most consistent with the Aleutian disease virus acting as a direct and somewhat selective stimulus to plasma cell proliferation. There is no evidence that the arterial and glomerular lesions of Aleutian disease have an immunologic pathogenesis. It seems possible that these vascular changes may be directly caused by the viral agent, or may be the result of the increased gamma globulin levels.  (+info)

AUTOIMMUNE DISEASE IN NZB/BL MICE. I. PATHOLOGY AND PATHOGENESIS OF A MODEL SYSTEM OF SPONTANEOUS GLOMERULONEPHRITIS. (8/102)

This study, based upon 528 laboratory examinations and 16 complete autopsies of NZB/Bl mice, deals with autoimmune manifestations (as shown by hypergammaglobulinemia, Coombs positive hemolytic anemia, and the occasional presence of lupus- and rheumatoid-like factors) and mainly with the pathology and the pathogenesis of glomerulonephritis in these mice, a model system of membranous glomerulonephritis with spontaneous and insidious onset, progression through chronic stages, and almost certainly induced by immunological, and autoimmune, mechanisms. The earliest and lasting histological change was hyaline thickening of the capillary walls and adjacent intercapillary regions of the glomerular tufts, corresponding in location to polysaccharide-rich capillary basement membrane and mesangial materials. Distributed focally and diffusely in the glomerular tuft and eventually sparing no glomerulus, hyaline, granular, and fibrillar ("spongy fiber") materials produced narrowing of capillary lumens by concentric or eccentric encroachment upon them. In the later stages hyaline lobulation and sclerosis of the glomerular tufts occurred. Thus the lesions corresponded to those seen in human focal and diffuse membranous, chronic lobular, and lastly (intracapillary) sclerosing glomerulonephritis. In all instances of glomerulonephritis the glomerular tufts contained selective localizations of mouse immunoglobulins corresponding in distribution to that of the hyaline and (PAS-positive) polysaccharide-rich materials in the focal and diffuse membranous and lobular lesions and in amounts increasing with the severity of glomerular disease. The mouse immunoglobulins were extracted from frozen sections of glomerulonephritic kidneys and were then capable of recombination with glomerular tufts in sections of autologous or isologous glomerulonephritic kidneys from which in vivo localized immunoglobulins had been extracted. The pattern of recombination with glomerular tufts was similar to that of in invo localized immunoglobulins. The extracted immunoglobulins did not show affinity for mouse red cells (in the indirect Coombs test) nor for autologous or isologous cell nuclei (in the immunofluorescence test). The serum of mice with severe glomerulonephritis contained immunoglobulins with in vitro affinity for extracted autologous or isologous glomerular tufts. Thus circulating as well as localized antibodies were demonstrated. The immunogenic materials (autoantigens) may have been formed in the glomerular tufts or accumulated in them from some other source, such as the circulating plasma; however they corresponded in location to polysaccharide-rich capillary basement membrane and mesangial materials. The spleen was identified at the cellular level as the main site of formation of autoantibodies to red cells, as well as the main site of red cell destruction. Some evidence was brought forth suggesting that these autoantibodies were "heavy" or gammaM-globulins. More studies are in progress.  (+info)

TY - JOUR. T1 - Gene amplification as a common cause of inherited thyroxine-binding globulin excess. T2 - Analysis of one familial and two sporadic cases. AU - Mori, Yuichi. AU - Jing, Ping. AU - Kayama, Masato. AU - Fujieda, Kenji. AU - Hasegawa, Tomonobu. AU - Nogimori, Tsuyoshi. AU - Hirooka, Yoshifumi. AU - Mitsuma, Terunori. PY - 1999/8. Y1 - 1999/8. N2 - T4-binding globulin (TBG) is the major thyroid hormone transport protein in humans. Inherited abnormalities in the level of serum TBG have been classified as partial deficiency, complete deficiency and excess. A single nucleotide deletion or substitution in the TBG gene, located on Xq22, has been detected in partial and complete deficiencies. As for inherited TBG excess, the gene amplification has been recognized in two Japanese families recently. In this study, an additional three Japanese families, one familial (F-I) and two sporadic TBG excess (F-II, F-III), were analyzed. Serum TBG levels in hemizygous males were 73, 47 and 42 μg/ml, ...
In this issue there are a good number of papers dealing with clinical and basic research, in addition to good number of paper on woman health. We are starting with this issue as well as special series on learning difficulties a problem that is faced by family physicians and good understanding of the problem improve management outcome. Helvaci, M.R et al tried to understand significance of hyperlipoproteinemias, clinically. The authors concluded that the accelerated atherosclerotic process all over the body may be the major consequence of the metabolic syndrome. Hyperlipoproteinemias may actually be acute phase reactants indicating the disseminated endothelial damage, inflammation, fibrosis, and eventual atherosclerosis by aging all over the body.. A number of authors dealt with woman issues, Hasan, A et al; address the significance of sonographic diagnosis of vasa previa in pregnancy outcome. They performed a multicenter study in 3 private hospitals in Iraq during a 5 years period. The authors ...
Looking for online definition of bisalbuminaemia in the Medical Dictionary? bisalbuminaemia explanation free. What is bisalbuminaemia? Meaning of bisalbuminaemia medical term. What does bisalbuminaemia mean?
Looking for online definition of pseudohyponatremia in the Medical Dictionary? pseudohyponatremia explanation free. What is pseudohyponatremia? Meaning of pseudohyponatremia medical term. What does pseudohyponatremia mean?
We studied the immune functions of two patients with angioimmunoblastic lymphadenopathy (AILD) in an attempt to determine whether the B cells were primarily hyperactive or, rather, if T cell abnormalities might underlie the B cell hyperactivity observed in these patients. We found that the B cells of the AILD patients did not proliferate spontaneously, nor were they induced to proliferate excessively by fresh normal T cells. In contrast, AILD T cells induced both autologous and allogeneic B cells to proliferate and to differentiate into Ig secreting cells. Spontaneous culture supernates of T cells obtained from each patient induced substantial proliferation of B cells (B cell-activating activity) as well as proliferation in a standard costimulatory assay (B cell growth factor activity). The culture supernate of a T cell line, which was established from one patient, showed both activities. The T cell line supernate also induced Ig production by staphylococcal A Cowan-activated B cells. None of ...
We studied the immune functions of two patients with angioimmunoblastic lymphadenopathy (AILD) in an attempt to determine whether the B cells were primarily hyperactive or, rather, if T cell abnormalities might underlie the B cell hyperactivity observed in these patients. We found that the B cells of the AILD patients did not proliferate spontaneously, nor were they induced to proliferate excessively by fresh normal T cells. In contrast, AILD T cells induced both autologous and allogeneic B cells to proliferate and to differentiate into Ig secreting cells. Spontaneous culture supernates of T cells obtained from each patient induced substantial proliferation of B cells (B cell-activating activity) as well as proliferation in a standard costimulatory assay (B cell growth factor activity). The culture supernate of a T cell line, which was established from one patient, showed both activities. The T cell line supernate also induced Ig production by staphylococcal A Cowan-activated B cells. None of ...
Free, official information about 2013 (and also 2015) ICD-9-CM diagnosis code 790.5, including coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion.
Free, official coding info for 2018 ICD-10-CM R74.9 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Novel acyl-derivatives of the β-hydroxy-γ-butyrobetaine are disclosed (typically pyruvyl carnitine hydrochloride) which are useful therapeutic agents in the treatment of cardiac disorders, hyperlipidoemias and hyperlipoproteinemias.
Most patients with HH are asymptomatic; however, when patients present with symptoms, they are frequently nonspecific and include weakness, fatigue, lethargy, and weight loss. Specific, organ-related symptoms include abdominal pain, arthralgias, and symptoms and signs of chronic liver disease. Increasingly, most patients are now identified before they have symptoms, either through family studies or from the performance of screening iron studies. Several prospective population studies have shown that C282Y homozygosity is found in about 1 in 250 individuals of Northern European descent, with the heterozygote frequency seen in approximately 1 in 10 individuals. It is important to consider HH in patients who present with the symptoms and signs known to occur in established HH. When confronted with abnormal serum iron studies, clinicians should not wait for typical symptoms or findings of HH to appear before considering the diagnosis. However, once the diagnosis of HH is considered, either by an ...
The close relationship which seems to exist between lymphocytes and plasma cells has recently been the subject of much discussion.1, 2 The frequent occurrence of apparently identical serum protein abnormalities in patients with malignant lymphoma, lymphatic leukemia and multiple myeloma, as demonstrated by paper electrophoresis, has been felt to be of particular significance. The consensus seems to be that plasma cells probably represent transitional forms of lymphocytes, as had been suggested by the work of Sundberg3 and others,4 and that both are capable of synthesizing abnormal serum proteins.. Although serum proteins of the myeloma type have occasionally been reported in ...
However others have shown that healthy individuals supplemented for 4 weeks with hempseed exhibited a lower total-to-HDL cholesterol ratio 24 A higher total:HDL cholesterol ratio is associated with coronary heart disease and has a worse prognosis after a myocardial infarction 29 30 Clearly the issue is not resolved yet. The population studied (healthy vs clinically compromised) the dosages of hempseed used the presentation administered (whole hempseed vs milled hempseed vs hemp oil vs purified LA) the duration of the dietary intervention the composition of the diet are all factors that may be critical in producing the effects (of lack of effects) in these studies. More research is needed in order to understand if these specific conditions influence Contact Rick Simpson Hemp Oil cardiovascular efficacy and to understand which metabolic factors are most sensitive cannabidiol oil anxiety dosage (hypertriglyceridemia hypercholesterolemia low HDL-C or other hyperlipoproteinemias) to this kind of ...
WINPRO® Blood Protein Supplements are powered by our unique and proprietary animal blood protein blend, K-Thrive™ FORMULA D. Designed to help your dog thrive and live to their full potential, its an essential mix of concentrated blood fractions including plasma, serum, albumin, IgG and IgA. The animal blood proteins i
Harnessing The Power Of Blood Proteins To Help Heal Your Dog Naturally The Worlds 1st And Only Blood Protein Supplements For Dogs. ...
High blood protein levels rarely cause symptoms, according to Mayo Clinic. However, a high blood protein level might be a symptom itself of a disease or condition, and doctors can order further tests to determine the cau... More » ...
Proteins in our blood could in future help provide a comprehensive liquid health check, assessing our health and predicting the likelihood that we will we will develop a range of diseases, according to research published today in Nature Medicine.
Angioimmunoblastic T-cell lymphoma (AITL, sometimes misspelled AILT) (formerly known as "angioimmunoblastic lymphadenopathy with dysproteinemia") is a mature T-cell lymphoma of blood or lymph vessel immunoblasts characterized by a polymorphous lymph node infiltrate showing a marked increase in follicular dendritic cells (FDCs) and high endothelial venules (HEVs) and systemic involvement. Patients with this disease usually present at an advanced stage and show systemic involvement. The clinical findings typically include a pruritic skin rash and possibly edema, ascites, pleural effusions, and arthritis. Due to the systemic nature of this disease, neoplastic cells can be found in lymph nodes, liver, spleen, skin, and bone marrow. This disease was originally thought to be a premalignant condition, termed angioimmunoblastic lymphadenopathy, and this atypical reactive lymphadenopathy carried a risk for transformation into a lymphoma. Currently, it is postulated that the originating cell for this ...
Blood proteins, also termed plasma proteins or serum proteins, are proteins present in blood plasma. They serve many different functions, including transport of lipids, hormones, vitamins and minerals in activity and functioning of the immune system. Other blood proteins act as enzymes, complement components, protease inhibitors or kinin precursors. Contrary to popular belief, haemoglobin is not a blood protein, as it is carried within red blood cells, rather than in the blood serum. Serum albumin accounts for 55% of blood proteins, and is a major contributor to maintaining the osmotic pressure of plasma to assist in the transport of lipids and steroid hormones. Globulins make up 38% of blood proteins and transport ions, hormones, and lipids assisting in immune function. Fibrinogen comprises 7% of blood proteins; conversion of fibrinogen to insoluble fibrin is essential for blood clotting. The remainder of the plasma proteins (1%) are regulatory proteins, such as enzymes, proenzymes, and ...
High blood protein (hyperproteinemia) is an increase in the concentration of protein in the bloodstream. High blood protein is not a specific disease or condition in itself, but it might indicate you have a disease.. High blood protein rarely causes signs or symptoms on its own. But sometimes it is uncovered while youre having blood tests done as part of an evaluation for some other problem or symptom.. If your doctor discovers high blood protein during an evaluation, he or she may recommend additional tests to determine if there is an underlying problem.. A total protein test can determine whether you have high blood protein. Other more-specific tests, including serum protein electrophoresis (SPEP), can help determine the exact source, such as liver or bone marrow, as well as the specific protein type involved in your high blood protein levels. Your doctor may order an SPEP if he or she suspects you have a bone marrow disease.. ...
Get information, facts, and pictures about Blood proteins at Encyclopedia.com. Make research projects and school reports about Blood proteins easy with credible articles from our FREE, online encyclopedia and dictionary.
Research Overview. The AHA statement reviews and grades current evidence regarding cardiometabolic effects of childrens intake of added sugars. Longitudinal studies and randomized controlled trials link added sugars, and particularly SSBs, with increased daily calorie intake, excess weight gain, and increased risk of obesity.1,2. Intervention trials of added sugars and other CVD risk factors in youth are limited, but longitudinal and cross-sectional studies support an association of high intake with abnormal serum triglyceride and HDL levels. More research is needed to evaluate the potential for sugar intake to affect nonalcoholic fatty liver disease in children. Despite the strength of evidence in adults,2,3 studies are likewise inconclusive on whether added sugars are related to insulin resistance and diabetes or blood pressure in children.1 Its possible, but not yet shown, that children who are overweight or with particular genetic polymorphisms may be more strongly affected than ...
Comments are welcomed and encouraged. The purpose of comments on our site is to expand knowledge, engage in thoughtful discussion, and learn more from readers. Criticism and skepticism can be far more useful than praise and unflinching belief. Theres an art and science to critical thinking and how to conduct yourself. Theres a multitude of fallacious appeals we could spell out, but a good rule of thumb is not to attack the person, attack the ideas. Dont look for the flaws in the person, look for the flaws in the hypothesis. Lets keep the brawling to movies depicting minor league hockey teams and political "news" shows. Thank you for adding to the discussion ...
Ive never felt the need to post on a Cavalier forum, but now I feel myself needing to ask advice from fellow owners. Out Cavalier, Bobby, is 10 years old and has had a medium grade murmur for the last 4 years, but no outward symptoms of CHF/MVD. Following a short bout of diarrhoea and vomiting last week he has had much laboured breathing over the weekend, even when asleep, and has been very restless. Hes eating fine, and no coughing, just lethargic and not wanting to go upstairs.
Ive never felt the need to post on a Cavalier forum, but now I feel myself needing to ask advice from fellow owners. Out Cavalier, Bobby, is 10 years old and has had a medium grade murmur for the last 4 years, but no outward symptoms of CHF/MVD. Following a short bout of diarrhoea and vomiting last week he has had much laboured breathing over the weekend, even when asleep, and has been very restless. Hes eating fine, and no coughing, just lethargic and not wanting to go upstairs.
Hyperlipoproteinemia symptoms, causes, diagnosis, and treatment information for Hyperlipoproteinemia (Hyperlipoproteinemia) with alternative diagnoses, full-text book chapters, misdiagnosis, research treatments, prevention, and prognosis.
low blood protein - The importance of protein when it comes to body building cannot be emphasized enough. If you want your workout and exercise regime to be effective, then consuming a certain amount of protein immediately before your workout and immediately after your worko
When someone in Colorado goes to an emergency room with head trauma, a physician will normally perform a CT scan to look for ... Brain Injury
In this article the importance of blood proteins for drug dosing regimes is discussed. A simple mathematical model is presented for estimating recommended drug doses when the concentration of blood proteins is decreased. Practical guidance for drug dosing regimes is discussed and given in the form of a figure. It is demonstrated that correction of drug dosing regimes is needed only for when there is a high level of drug conjugation with blood proteins and a high degree of hypoalbuminaemia. An example of the use of this model is given.
Hyperlipoproteinemia answers are found in the Diseases and Disorders powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Compare risks and benefits of common medications used for Hyperlipoproteinemia. Find the most popular drugs, view ratings, user reviews, and more...
Pasquardini, L., Berneschi, S., Barucci, A., Cosi, F., Dallapiccola, R., Insinna, M., Lunelli, L., Conti, G. N., Pederzolli, C., Salvadori, S. and Soria, S. (2013), Whispering gallery mode aptasensors for detection of blood proteins. J. Biophoton., 6: 178-187. doi: 10.1002/jbio.201200013 ...
This study...examined immune proteins not as separate entities but as a part of specific protein networks... in schizophrenia patients
Phys.org internet news portal provides the latest news on science including: Physics, Space Science, Earth Science, Health and Medicine
The study, published today in the journal Nature, characterised the genetic underpinnings of the human plasma proteome, identifying nearly 2,000 genetic associations with almost 1,500 proteins. Previously, there was only a small fraction of this knowledge, mainly because researchers could measure only a few blood proteins simultaneously in a robust manner.
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MGSNKSKPKD asqrrrslep aENVHGAGGG AFPASQTPSK PASADGHRGP SAAfapaaae pKLFGGFNSS DTVTSPQRAG PLAggvttfv alydyesrte tdlsfkkger lqivnntegd wwlahslsTG QTGYIPSNYV apsdsiqaee wyfgkitrre serlllnaen prgtflvres ettkgaycls vsdfdnakgl nvkhykirkl dsggfyitsr tqfnslqqlv ayyskhadgl chrlttVCPT SKPQtqglak daweipresl rlevklgqgc fgevwmgtwn gttrvaiktl kpgtmspeaf lqeaqvmkkl rheklvqlya vvseepiyiv teymskgsll dflkgetgky lrlpqlvdma aqiasgmayv ermnyvhrdl raanilvgen lvckvadfgl arliedneyt arqgakfpik wtapeaalyg rftiksdvws fgillteltt kgrvpypgmv nrevldqver gYRMPCPPEC PESlhdlmcq cwrkepeerp tfeylqafle dyftstepqy ...
The aggressive diagnosis and treatment of patients with type 2 diabetes, metabolic syndrome or insulin resistance, and atherogenic dyslipidemia has been advocated by the ADA, AHA, NCEP, and NLA. By diagnosing and aggressively treating patients at increased risk for cardiovascular disease, clinicians can reduce the burden these diseases place on patients and society (Journal of the American Academy of Physician Assistants). ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Human Serum Albumin (HSA) is a protein commonly used in vaccines and often administered for serious burn injuries and liver disease and commonly in short supply due to a lack of donors. That's why researchers from Wuhan University have figured out how to grow it-not in people, but in rice.
Health,Only two days ago China sought to turn the tables by declaring that s...But the Asian giants satisfaction remained shortlived. Now Chine...Experts suggest that the fake product could be life-threatening ... These were out-and-out fakes he added. Officials did not say ...The administration said its investigations had effectively clea...,China,Admits,Fake,Blood,Protein,Used,in,Drips,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Looking for Thyroxine-binding globulin? Find out information about Thyroxine-binding globulin. any of a large family of proteins protein, any of the group of highly complex organic compounds found in all living cells and comprising the most abundant... Explanation of Thyroxine-binding globulin
Your thyroid gland produces T3 and T4, which are hormones that help regulate body functions. Most of the T3 and T4 in your body binds with proteins produced by your body. The small amounts of T3 and T4 that dont bind with protein are referred to as "free.". Most of the protein-bound T3 and T4 in your body bind to thyroxine-binding globulin (TBG). The serum TBG level test measures the amount of TBG in your blood. This can help doctors assess thyroid problems.. TBG deficiency usually accompanies an underlying illness. A low TBG level doesnt cause symptoms. The illness causing the low TBG level can cause symptoms, however.. ...
Crestor appears as effective as atorvastatin at lowering cholesterol; however, grapefruit products do not affect Crestor to the same extent as atorvastatin. TriCor - Prescribed for Hypertriglyceridemia, Hyperlipoproteinemia, Hyperlipoproteinemia Type IIa - Elevated LDL, Hyperlipoproteinemia Type IV - Elevated VLDL, Hyperlipoproteinemia Type IIb - Elevated LDL .
Chinas surging trade surplus could exacerbate tensions with the U.S. and European Union. Plus, Chinas tainted-products problem grows and a new setback for Thaksin.
Last week, the Barrington School Department facilitated 15 focus group sessions to discuss key points for the districts five-year strategic plan. The sessions were specifically geared …
Thirteen patients with lymphocytic interstitial pneumonitis were seen at the Mayo Clinic from 1966 through 1976. The group included nine women and four men, with a mean age of 50.7 years. Their primary complaints were cough, dyspnea, and loss of weight. Chest roentgenographic features were predominantly basilar, coarse interstitial-alveolar infiltrations. Pulmonary function studies showed restrictive ventilatory impairments with a low CO diffusing capacity in all 13 patients. Lung biopsies in all cases showed diffuse interstitial infiltrations, consisting of mature lymphocytes and plasma cells. Ten of the 13 patients had an associated dysproteinemia, including two patients with hypogammaglobulinemia. Three patients had coexistent Sjögrens syndrome, including two with localized amyloidosis. Although lymphocytic interstitial pneumonitis is a histologically distinct pulmonary lesion, it occurs with a variety of immune disorders. ...
Alexandersen, Soren, Uttenthal-Jensen, A and Aasted, B 1986, Demonstration of non-degraded Aleutian disease virus (ADV) proteins in lung tissue from experimentally infected mink kits. Brief report., Archives of Virology, vol. 87, no. 1-2, pp. 127-133, doi: 10.1007/BF01310549. ...
FHCL1, FHC, FH, Hyperlipoproteinemia, Type II, Hyperlipoproteinemia, Type IIA, Hyper-Low-Density-Lipoproteinemia, Hypercholesterolemic Xanthomatosis, Familial, LDL Receptor Disorder ...
A deficiency of the enzyme alpha 1-antitrypsin results in low levels or a lack of an essential blood protein that protects tissues in the lungs from being destroyed by enzymes released from the bodys own white blood cells.
Press Release issued Oct 2, 2012: Familial Hypercholesterolemia (Type II Hyperlipoproteinemia) - Pipeline Review, H2 2012, provides an overview of the Familial Hypercholesterolemia (Type II Hyperlipoproteinemia) therapeutic pipeline. This report provides information on the therapeutic development for Familial Hypercholesterolemia (Type II Hyperlipoproteinemia), complete with latest updates, and special features on late-stage and discontinued projects. It also reviews key players involved in the therapeutic development for Familial Hypercholesterolemia (Type II Hyperlipoproteinemia). Familial Hypercholesterolemia (Type II Hyperlipoproteinemia) - Pipeline Review, H2 2012 is built using data and information sourced from Global Markets Directs proprietary databases, Company/University websites, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources, put together by Global Markets Directs team.
China Gq/Gf Human Blood Proteins Tube Centrifuge Separator, Find details about China Lab Equipment, Medical Equipment from Gq/Gf Human Blood Proteins Tube Centrifuge Separator - Guangzhou Fuyi Liquid Separation Technology Co., Ltd.
Medical definition of thyroxine-binding globulin: a blood serum glycoprotein that is synthesized in the liver and that binds tightly to thyroxine and less firmly to triiodothyronine preventing their removal from the blood by the kidneys and releasing them as needed at sites of activity -abbreviation TBG-called also thyroid-binding globulin.
Blood samples of coalfish from Norwegian and Icelandic waters were collected and analyzed for hemoglobin, serum protein, and serum esterase variations in order to study the relation between the two coalfish stocks. Clear intraspecific variation was found in the serum transferrins, but the distributions of phenotypes were nearly the same in the sample from Iceland as in the total samples from Norwegian waters ...
The circadian pattern in levels of serum total testosterone (T) in men becomes blunted with normal aging. However, because T not bound to sex hormone-binding globulin (non-SHBG-T) is felt to be a better ...
A protein has been discovered in the blood of people who go on to develop mild cognitive impairment several years later. Dr. Steven Kiddle of Kings College
How can you tell how old someone is? Of course, you could scan their drivers license or look for signs of facial wrinkles or gray hair. But, as researchers just found in a new study, you also could get pretty close to the answer by doing a blood test.
Baxter's BioScience business produces recombinant and blood plasma proteins to treat hemophilia and other bleeding disorders; ... Feldman, EA; Bayer R (1999). Blood feuds: AIDS, blood, and the politics of medical disaster. Oxford University Press. pp. 49-50 ... "Contaminant Found in Blood Thinner", Washington Post (Online edition), March 5, 2008 "Baxter probe focuses on US-owned China ... In 1939 the company developed a vacuum-type collection container, extending the shelf life of blood from hours to weeks. In ...
Total protein in the blood may be low. The disorder can be screened during pregnancy by finding elevated levels of alpha- ... combined with the loss of blood protein. This is because proteins in the blood normally keep fluids in the blood stream, and ... It is an inherited disorder. The condition is caused by a defect in the protein nephrin, which is found in the kidney. Proteins ... Blood pressure may be high. The patient may have signs of malnutrition. A urinalysis reveals large amounts of protein and the ...
This seemingly paradoxical propensity to develop thrombosis in a disorder causing a decrease in a critical protein for blood ... make small amounts of this critical coagulation protein, blood levels of fibrinogen are low, and individuals with the disorder ... Congenital hypofibrinogenemia must be distinguished from: a) congenital afibrinogenemia, a rare disorder in which blood ... Individuals with this disorder are usually less symptomatic than patients with other fibrinogen disorders because their ...
For severe bleeding, for example from bleeding disorders, recombinant factor VIIa-a protein that assists blood clotting-may be ... If blood products are needed, a greater use of fresh frozen plasma and platelets relative to packed red blood cells has been ... Other tests should be performed to get a baseline measurement of their current blood chemistry, such as a arterial blood gas or ... ISBN 978-0-7817-6275-5. "309.81 Posttraumatic Stress Disorder". Diagnostic and Statistical Manual of Mental Disorders. ...
... an allowance of fluid and protein normally contained within blood to pass) and disordered blood clotting.[26][27] These changes ... less blood circulates in the blood vessels, and the blood pressure becomes so low that it cannot supply sufficient blood to ... Blood donation. Outbreaks of dengue fever increases the need for blood products while decreasing the number of potential blood ... low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure ...
... a blood disorder that reduces the production of the iron-containing protein hemoglobin which carries oxygen to cells and which ... The amount of Hb Lepore in the patients blood ranged from 8 to 30%, the remainder being fetal hemoglobin (Hb F) which is ...
... measure Epstein-Barr virus genome load in peripheral blood of pediatric transplant patients with lymphoproliferative disorders ... Viral LMP2A mRNA is frequently detected in peripheral blood B lymphocytes and the protein is often present in tumor biopsies ... Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) are two viral proteins of the Epstein-Barr virus. LMP2A/LMP2B are ... "The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases". Virology. ...
Tests of protein levels in the blood help screen for both kidney and liver disorders. Serum total protein (TP) Human serum ... Serum glucose Calcium Blood urea nitrogen (BUN) Creatinine Electrolyte levels and the balance among them are tightly regulated ... Typically, the patient fasts for ten or twelve hours before the blood is drawn for the test-this is particularly important for ... The comprehensive metabolic panel, or chemical screen, (CMP; CPT code 80053) is a panel of 14 blood tests which serves as an ...
... a therapy for people suffering from a rare and life-threatening blood disorder known as protein C deficiency. Research at OMRF ... to assist research involving intracellular Ca2+ measurements and protein-protein interactions. "Prescott, Stephen M". Oklahoma ... Esmon's research has led to the development of two FDA-approved drugs: Xigris, a treatment for severe sepsis (blood poisoning ... Study participation involves completing paperwork and donating a one-time blood sample. In 1956, OMRF established its Sir ...
... an allowance of fluid and protein normally contained within blood to pass) and disordered blood clotting. These changes appear ... less blood circulates in the blood vessels, and the blood pressure becomes so low that it cannot supply sufficient blood to ... low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure ... The white blood cells respond by producing a number of signaling proteins, such as cytokines and interferons, which are ...
This can lead to misdiagnosis or over-diagnosis of blood clotting disorders as many proteins exist at levels during stages of ... The haemostatic (blood clotting) system involves the interaction of proteins in the blood, the blood vessel wall and the flow ... Protein C is active in anticoagulation (anti-clotting) and breaking down blood clots. A newborn form of protein C has been ... Studies have shown that there are structural differences in some of the major blood clotting proteins in newborns and children ...
Blood. 95 (5): 1788-96. PMID 10688839. "Entrez Gene: CEP110 centrosomal protein 110kDa". Human CNTRL genome location and CNTRL ... "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12; ... Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110. This gene encodes a ... 2003). "A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase ...
The blood types of humans are due to variations in surface glycoproteins of red blood cells. Disorders of the proteins in these ... Several blood tests involve red blood cells. These include a RBC count (the number of red blood cells per volume of blood), ... Main article: Blood transfusion. Red blood cells may be given as part of a blood transfusion. Blood may be donated from another ... Packed red blood cells (pRBC) are red blood cells that have been donated, processed, and stored in a blood bank for blood ...
... rare acquired clonal disorder of red blood cell surface proteins) Direct physical damage to RBCs Microangiopathic hemolytic ... Hematologic diseases are disorders which primarily affect the blood. Hematology includes the study of these disorders. ... destruction of red blood cells) Genetic disorders of RBC membrane Hereditary spherocytosis Hereditary elliptocytosis Congenital ... increase in the number of white blood cells) Thrombocytosis (increase in the number of platelets) Myeloproliferative disorder ...
... rare acquired clonal disorder of red blood cell surface proteins) Liver disease Drug induced hemolysis has large clinical ... Alloimmune hemolytic blood transfusion reactions (i.e., from a non-compatible blood type) Drug induced immune mediated ... It occurs when drugs actively provoke red blood cell destruction. It can be divided in the following manner: Drug-induced ... Malaria Babesiosis Septicemia Membrane disorders Paroxysmal nocturnal hemoglobinuria ( ...
... a protein structural motif Hemophagocytic lymphohistiocytosis, a blood disorder Ulanhot Airport, in Inner Mongolia, China High ...
... blood coagulation disorders, inherited MeSH C15.378.100.425.037 --- activated protein c resistance MeSH C15.378.100.425.056 ... coagulation protein disorders MeSH C15.378.100.141.036 --- activated protein c resistance MeSH C15.378.100.141.072 --- ... protein c deficiency MeSH C15.378.147.890 --- protein s deficiency MeSH C15.378.190.196 --- anemia, aplastic MeSH C15.378. ... protein c deficiency MeSH C15.378.925.800 --- protein s deficiency MeSH C15.378.925.850 --- purpura, thrombotic ...
... suffered a stroke following their game against Richmond Kickers caused by Protein S deficiency which is a rare blood disorder ...
... his work in transgenic proteins to treat hemophilia and other blood-related disorders, as well as important contributions in ... and private companies dedicated to treating blood-borne disorders, most recently as Chief Scientific Officer at Inspiration ... He was known for, among other things, his commitment to improving blood safety, ... and was a member of the Scientific Steering Committee for Blood Products at Walter Reed Army Institute of Research and Chairman ...
This causes an increase in hematocrit, serum total protein, blood viscosity and, as a result of increased concentration of ... osmotic effect that keeps electrolyte concentration balanced and protects the body from infection and other blood disorders.[3] ... Blood plasma is a yellowish coloured liquid component of blood that normally holds the blood cells in whole blood in suspension ... Blood plasma is separated from the blood by spinning a tube of fresh blood containing an anticoagulant in a centrifuge until ...
Mutations in the PROS1 gene can lead to Protein S deficiency which is a rare blood disorder which can lead to an increased risk ... different roles for protein S and the protein S-C4b binding protein complex". Blood. 103 (4): 1192-201. doi:10.1182/blood-2003- ... 1989). "Familial protein S deficiency with a variant protein S molecule in plasma and platelets". Blood. 74 (1): 213-21. PMID ... Protein S is partly homologous to other vitamin K-dependent plasma coagulation proteins, such as protein C and factors VII, IX ...
... a protein involved in the growth of blood vessels. Certolizumab pegol is a Fab chemically linked to PEG, and it treats various ... inflammatory disorders by binding away TNFα. Fab antibodies also have diagnostic use. Arcitumomab is a mouse antibody that ... The Fab abciximab, which inhibits blood clotting, works by disabling Glycoprotein IIb/IIIa fount on platelets.[5] Ranibizumab, ... Sulesomab, an antigen that recognizes proteins on the surface of granulocytes, is used to label out infections, again using the ...
... lack of blood supply to the heart muscles) Speech disorders Haemoglobin decrease Proteinuria (protein in the urine; usually ... of blood vessels) Confusion Coordination disturbance Miosis Sleep disorder Rash Hypertonia Abdominal pain Weight loss Visual ... high blood pressure) Allergic reactions (e.g. dyspnoea (shortness of breath), bronchospasm, wheezing, angioneurotic oedema) ...
Another sign of this disorder is high levels of certain mast-cell chemicals and proteins in a person's blood and sometimes in ... In rare cases in which mastocytosis is cancerous or associated with a blood disorder, the patient may have to use steroids and/ ... Researchers also think mast cells may have a role in the growth of blood vessels (angiogenesis). No one with too few or no mast ... Mastocytosis, a type of mast cell disease, is a rare mast cell activation disorder of both children and adults caused by the ...
... white blood cell Progressive multifocal leukoencephalopathy, rare and usually fatal disorder Promyelocytic leukemia protein, ... tumor suppressor protein Pine Mountain Lake, California, private gated community in Groveland, California. ...
... (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII ... Defects in this gene result in hemophilia A, a recessive X-linked coagulation disorder. Factor VIII is produced in liver ... This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which ... This interaction sets off a chain of additional chemical reactions that form a blood clot. Factor VIII participates in blood ...
Disorders[edit]. Main article: Eating disorder. Physiologically, eating is generally triggered by hunger, but there are ... Carnivorous mammals have a simple digestive tract because the proteins, lipids and minerals found in meat require little in the ... The brain detects insulin in the blood, which indicates that nutrients are being absorbed by cells and a person is getting full ... The brain checks for glucoprivation on its side of the blood-brain barrier (since glucose is its fuel), while the liver ...
Hemoglobin is a protein found in red blood cells that carries oxygen throughout the body. It's made up of alpha globin and beta ... Alpha thalassemia is a faintly common blood disorder worldwide. Thousands of infants with Hb Bart syndrome and HbH disease are ... Alpha Thalassemia-Abnormal Morphogensis is a group of blood disorders that affect the way the body makes hemoglobin. ... Red blood cells, which contain hemoglobin deliver oxygen to all parts of the body. All cells have a nucleus at their center ...
In addition to eating a diet filled with essential nutrients, try to add more lean proteins and foods low in sugars. This will ... keep your blood sugar levels stable. Be sure to also drink enough water and drink alcohol in moderation. Try adding a ... Seasonal Affective Disorder, seasonal affective disorder light, Seasonal affective disorder light therapy, Severe Depression, ... Give Seasonal Affective Disorder the Cold Shoulder. Being more at risk for SAD than the men in your life doesnt mean settling ...
If youre like most people with seasonal affective disorder, your symptoms start in the fall and may continue into the winter ... Less often, seasonal affective disorder causes depression in the spring or early summer. ... Seasonal affective disorder (also called SAD) is a type of depression that occurs at the same time every year. ... Family history. As with other types of depression, those with seasonal affective disorder may be more likely to have blood ...
"Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a ... Differential Protein Expression in Psychotic Disorder Gene Names Protein Names Protein ID P Value FC in PD FDR A2M Alpha-2- ... Differential Protein Expression in Psychotic Disorder Gene Names Protein Names Protein ID P Value FC in PD FDR A2M Alpha-2- ... Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a ...
... bi-polar disorder, attention deficit hyperactivity disorder [ADHD], and major depression). The paper, published in the ... A Blood Gene Found in the Brain. Although the NGC has been recognized as a key player in proper brain function, information ... This suggests a link between eNOS production and certain mental disorders that occur due to a dysregulation of arousal. ... However, he cites that "there have been associations between certain psychiatric disorders and the eNOS locus in GWAS studies ...
Blood Coagulation Factor Deficiencies. On-line free medical diagnosis assistant. Ranked list of possible diseases from either ... Coagulation Protein Disorders (Blood Coagulation Factor Deficiencies). Hemorrhagic and thrombotic disorders resulting from ... Ranked list of diseases related to "Coagulation Protein Disorders"Drugs, active principles and "Coagulation Protein Disorders" ...
Ask questions and get answers about Blood Disorder. Our support group helps people share their own experience. 92 questions, 20 ... Blood Disorders - How high is high protein level in blood? Is it a death sentence?. Posted 25 May 2017 • 1 answer ... Join the Blood Disorder group to help and get support from people like you. ... Our support group for Blood Disorder has 92 questions and 20 members. Updated 22 Sep 2018. ...
... blood disorders - Answer: Hemoglobin deficiency results in anemia and can be caused due to various ... ... Blood Disorders - How high is high protein level in blood? Is it a death sentence?. Posted 25 May 2017 • 1 answer ... How to improve the Haemoglobin level in blood?. Asked. 24 May 2010 by grandhijaya. Active. 24 May 2010. Topics. blood disorders ... Blood Disorders - I have ITP and am wondering if theres anything I can do/eat to improve my?. Posted 29 Apr 2015 • 1 answer ...
blood; blood coagulation factors; coagulation protein disorders; cryoprecipitate coagulum; fibrinogen; transfusion. PMID:. ... particularly transmission of blood-borne pathogens and transfusion-related acute lung injury. As a result of these safety ...
Blood Protein Disorders. Hematologic Diseases. Hemorrhagic Disorders. Lymphoproliferative Disorders. Immunoproliferative ... Disorders. Immune System Diseases. Thalidomide. Ferrous fumarate. Immunosuppressive Agents. Immunologic Factors. Physiological ... Hemostatic Disorders. Vascular Diseases. Cardiovascular Diseases. Paraproteinemias. ...
Blood Protein Disorders. Hematologic Diseases. Lymphoproliferative Disorders. Lymphatic Diseases. Metabolism, Inborn Errors. ... Adenosine Deaminase Deficiency Autosomal Recessive Disorder Immune System Disorder Purine-Nucleoside Phosphorylase Deficiency ... DNA Repair-Deficiency Disorders. Metabolic Diseases. Genetic Diseases, X-Linked. Genetic Diseases, Inborn. ... Induction of Mixed Hematopoietic Chimerism in Patients With Severe Combined Immunodeficiency Disorders Using Allogeneic Bone ...
Blood Protein Disorders. Hemorrhagic Disorders. Lymphoproliferative Disorders. Immunoproliferative Disorders. Immune System ... MedlinePlus related topics: Amyloidosis Blood Disorders Kidney Failure Kidney Transplantation Multiple Myeloma ... Combined Bone Marrow and Renal Transplantation for Hematologic Disorders With End Stage Renal Disease. The safety and ... renal recovery of their renal failure over a 90 day period of therapy for their underlying malignancy or other blood disorder. ...
Blood Protein Disorders. Hematologic Diseases. Hemorrhagic Disorders. Lymphoproliferative Disorders. Immunoproliferative ... Disorders. Immune System Diseases. Dexamethasone. Dexamethasone acetate. Lenalidomide. Bortezomib. BB 1101. Antibodies, ... Hemostatic Disorders. Vascular Diseases. Cardiovascular Diseases. Paraproteinemias. ...
Evidence against a blood derived origin for transforming growth factor beta induced protein in corneal disorders caused by ... Evidence against a blood derived origin for transforming growth factor beta induced protein in corneal disorders caused by ... PURPOSE: Several inherited corneal disorders in humans result from mutations in the transforming growth factor beta induced ... a common environmental protein contaminant. Thus, the anti-p68(beta ig-h3) antiserum recognizes both TGFBIp and keratin-1. In ...
ASD is a very heterogeneous disorder, and if we can identify bio markers for even a subgroup of ASD patients, then that would ... Scientists have identified two proteins in the blood that may help diagnose autism spectrum disorder in its early stage with 82 ... Identified two proteins in the blood that may help diagnose autism spectrum disorder in its early stage. By overall health - ... Scientists have identified two proteins in the blood that may help diagnose autism spectrum disorder in its early stage with 82 ...
Blood-brain Barrier Proteins When Blocked may Improve Effectiveness of Brain Disorder Drugs. Scientists have found that ... Rare Nerve Disease in Horses Similar to Human Brain Disorder. Study shows that horse tissue contains proteins that are commonly ... Two Genetic Mutation in GPT2 Linked to Unnamed Brain Disorder The mutations of GPT2 leaves the brain without biosynthetic ... Guidelines on Use of Botulinum Toxin for Brain Disorders Updated. Botulinum toxin is generally safe and effective for treating ...
Investigation of the causes of disordered processes of the restoration of blood proteins in irradiated dogs after blood loss. I ... Investigation of the causes of disordered processes of the restoration of blood proteins in irradiated dogs after blood loss. I ...
Effect of Genotype and Maternal Affective Disorder on Intronic Methylation of FK506 Binding Protein 5 in Cord Blood DNA.docx ... Table_1_Effect of Genotype and Maternal Affective Disorder on Intronic Methylation of FK506 Binding Protein 5 in Cord Blood DNA ... cord blood FKBP5 in utero environment DNA methylation gene-environment interaction affective disorder toxic stress ... Sixty cord blood DNA samples from the Boston Birth Cohort were genotyped at rs1360780 and studied for methylation changes as ...
BLOOD PROTEIN DISORDERS); lymphatic diseases include disorders relating to lymph, lymph nodes, and lymphocytes. ... Atopic dermatitis is a skin disorder with an itchy, red skin rash. This may be because certain proteins are increased in the ... The co-occurrence of pregnancy and a blood disease (HEMATOLOGIC DISEASES) which involves BLOOD CELLS or COAGULATION FACTORS. ... RATIONALE: Umbilical cord blood transplantation may be able to replace cells destroyed by chemotherapy or radiation therapy. ...
A protein has been discovered in the blood of people who go on to develop mild cognitive impairment several years later. Dr. ... Bipolar Disorder*Bipolar Disorder Symptoms. *Bipolar Disorder Treatment. *Bipolar Disorder Test. *Depression*Depression ... A protein has been discovered in the blood of people who go on to develop mild cognitive impairment several years later. Dr. ... Results suggested that blood levels of a protein called MAPKAPK5 tended to be lower in those whose cognitive ability declined. ...
We offer unparalleled expertise for the diagnosis of blood and bone marrow disorders as well as treatments for common disorders ... High blood protein is not a specific disease or condition. Certain proteins in the blood may be elevated as your body fights an ... Blood vessel disorder care Blood vessel disorders are often caused by abnormalities in the arteries and veins that carry blood ... Polycythemia vera is a rare blood disorder in which there is an increase in all blood cells, particularly red blood cells. The ...
Protein C, protein S, or other known blood clotting disorders or * Stroke, history of or ... Your risk for these serious problems is even greater if you have high blood pressure, high cholesterol in your blood, diabetes ... Using this medicine may increase your risk for having blood clots, strokes, or heart attacks. This risk may continue even after ... Blood clots (eg, deep vein thrombosis, pulmonary embolism), active or history of or ...
Excessive blood clotting may be caused by genetic disorders which are inherited from one or both parents. Two common disorders ... A blood clotting disorder is a result of the body making either too many blood clotting factors or too few anti-clotting ... I have Protein S deficiency I have Protein S deficiency n I had blood clots after I had my 1st son. I took Lovenox n Heparin ... What Causes Blood Clotting Disorders?. A blood clotting disorder is a result of the body making either too many blood clotting ...
I have a blood disorder called Protein C defiency. In short i get blood clots at the drop o... ...
A metabolic disorder is when abnormal chemical reactions in the body disturb the metabolic process, states MedlinePlus. The ... syndrome is a disorder where the patients own immune system attacks and destroys normal proteins in his blood, states Mayo ... What causes too much iron in the blood?. A: Hereditary hemochromatosis is a disorder that causes the body to absorb too much ... Metabolic disorders can develop as the result of diseases in organs such as the liver or pancreas. However, they can also be ...
Changes in the proteins of blood serum electrophoresis in cases of brain concussion]. - M Jarosz, T Merdi, J Kruszczyńska, H ... Blood Protein Disorders (etiology) *Blood Protein Electrophoresis. *Brain Concussion (blood) *Humans. Join CureHunter, for free ... Changes in the proteins of blood serum electrophoresis in cases of brain concussion].. Authors. M Jarosz, T Merdi, J ...
  • People can experience varying seasonal symptoms, including the "winter blues," which can begin in the fall, and a clinical disorder known as seasonal affective disorder (SAD) or seasonal depression. (chopra.com)
  • A study conducted at Duke University Medical Center found that patients with major depressive disorder who performed aerobic exercise were significantly less likely to have relapse symptoms compared to those who only took medication. (chopra.com)
  • WEDNESDAY, April 18, 2018 (HealthDay News) -- Wanda Sihanath didn't like the fact that her inherited blood disorder would not allow her to travel far from Chicago to attend college, but what could she do? (hon.ch)
  • Their study took blood from over 100 sets of healthy twin volunteers, of whom 55 were identical twin-pairs, and measured over 1,000 proteins in the samples. (psychcentral.com)
  • Ganz said the team was surprised to discover that about 200 of the original 1,000 proteins targeted had at least some predictive value. (ucsf.edu)
  • Endoglin binds a third growth factor that also plays a role in maintaining blood vessel health. (latimes.com)
  • Evidence against a blood derived origin for transforming growth factor beta induced protein in corneal disorders caused by mutations in the TGFBI gene. (duke.edu)
  • PURPOSE: Several inherited corneal disorders in humans result from mutations in the transforming growth factor beta induced gene (TGFBI), which encodes for the extracellular transforming growth factor beta induced protein (TGFBIp) that is one of the most abundant proteins in the cornea. (duke.edu)
  • A single nucleotide polymorphism (SNP: rs1360780) in FKBP5 (FK506 Binding Protein 5) has been shown to interact with exposure to childhood adversity to promote loss of methylation and increase in gene expression in adults. (figshare.com)
  • The gene for protein C is located on the long arm of chromosome 2 and nearly 200 pathogenic mutations of this gene have been described. (medscape.com)
  • Clinical features of thrombophilia in families with gene defects in protein C or protein S combined with factor V Leiden. (medscape.com)
  • Inoue H, Terachi SI, Uchiumi T, Sato T. The clinical presentation and genotype of protein C deficiency with double mutations of the protein C gene. (medscape.com)
  • Gu Y, Shen W, Zhang L, Zhang J, Ying C. Deficiency of antithrombin and protein C gene in 202 Chinese venous thromboembolism patients. (medscape.com)
  • Another way to characterize genetic disorders is by their pattern of inheritance, as single gene, multifactorial, chromosomal, or mitochondrial. (encyclopedia.com)
  • Single-gene disorders (also called Mendelian or monogenic) are caused by mutations in the deoxyribonucleic acid (DNA) sequence of one gene. (encyclopedia.com)
  • According to the Human Genome Project Information Web site (December 9, 2003, http://www.ornl.gov/sci/techresources/Human_Genome/medicine/assist.shtml), which is operated by the Department of Energy, there are an estimated 6,000 known single-gene disorders, which occur in about 1 in every 200 births. (encyclopedia.com)
  • Single-gene disorders are the result of either autosomal dominant, autosomal recessive, or X-linked inheritance. (encyclopedia.com)
  • Experimental allogeneic bone marrow transplantation can correct defective blood cells and gene therapy has been attempted. (vin.com)
  • The scientists also detected and cloned the gene that is the genetic blueprint for making the protein. (orlandosentinel.com)
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • In approximately 30 percent of cases, there is no family history of the disorder and the condition is the result of a spontaneous gene mutation. (bio-medicine.org)
  • The FMF gene, MEFV , encodes a 781-aa protein denoted pyrin (or marenostrin) ( 3 , 4 ), which is expressed primarily in neutrophils, eosinophils, and cytokine-activated monocytes ( 5 , 6 ). (pnas.org)
  • Protein C deficiency is caused by alterations (mutations) in the PROC gene. (rarediseases.org)
  • When a mutation of a gene occurs, the protein product may be faulty, inefficient, or absent. (rarediseases.org)
  • LFT (liver function test) is a series of blood tests done to detect the presence of liver disease. (medindia.net)
  • Liver enzymes are high due to liver injury from the excessive breakdown of red blood cells. (medindia.net)
  • If HELLP syndrome is left untreated, about 25% of the women develop serious complications, such as blood clots, placental abruption, renal failure, and liver damage. (medindia.net)
  • It can progress to eclampsia, which produces seizures and often fatal complications of the liver, kidneys, lungs, blood and nervous system. (latimes.com)
  • It can cause impaired function of kidneys, liver, brain and blood. (cyh.com)
  • Factor VII is a protein produced in the liver that plays an important role in helping your blood to clot. (aarpmedicareplans.com)
  • Less often, blood clots may form in the cerebral veins, the main vein of the liver (portal vein), and other areas. (rarediseases.org)
  • When a blood vessel is cut, the damaged blood vessel immediately constricts to slow blood loss. (aarpmedicareplans.com)
  • This new clot seals the broken blood vessel, and creates a protective covering for new tissue growth. (aarpmedicareplans.com)
  • A clot inside a blood vessel is also called a thrombus or an embolus. (clevelandclinic.org)
  • Much research is devoted to blood-vessel formation and the substances that control it. (orlandosentinel.com)
  • When a blood vessel is cut or torn, blood leaks out. (kelleycom.com)
  • The damaged blood vessel sends out chemical signals that an injury has occurred. (kelleycom.com)
  • Muscles in the damaged blood vessel wall tighten, narrowing its diameter and reducing blood flow inside the injured vessel. (kelleycom.com)
  • Pressure - placing your hand firmly on the bleeding to stop the flow of blood - pinches the blood vessel wall to close off the tear. (kelleycom.com)
  • Their work reveals a dual role for the protein pair, called Norrin/Frizzled-4, in managing the blood vessel network that serves the brain and retina. (redorbit.com)
  • Scientists already knew that Frizzled-4 is a protein located on the surface of the cells that create blood vessel walls throughout the body. (redorbit.com)
  • So blood vessel defects in the retina generally starve it of oxygen, causing blindness. (redorbit.com)
  • All of these results suggest that Norrin and Frizzled-4 play an important role in the proper timing and arrangement of the retinal blood vessel network, Nathans says. (redorbit.com)
  • Nathans explains that, normally, these blood vessel endothelial cells contain permeable "windows" and relatively loose "bolts" connecting the cells together. (redorbit.com)
  • Our research shows that blood vessel cells lacking Frizzled-4 are leaky. (redorbit.com)
  • Red blood cells carry oxygen to all parts of your body. (uwmedicine.org)
  • Globin, which holds the heme and influences how easily it stores and releases oxygen, is a protein consisting of two pairs of polypeptide chains. (encyclopedia.com)
  • Children with anemia do not have enough healthy red blood cells to carry oxygen throughout the body. (uhhospitals.org)
  • This disease is an inherited condition in which the body does not produce enough healthy red blood cells to carry oxygen throughout the body. (uhhospitals.org)
  • A new study shows that a protein found in blood alleviates anemia, a condition in which the body's tissues don't get enough oxygen from the blood. (medicalxpress.com)
  • Evidence suggests that the disorder is triggered when the fetus is not able to absorb sufficient amounts of oxygen from the placental blood supply. (latimes.com)
  • The result is an increase in the mother's blood pressure, which provides more oxygen to the fetus, but which also endangers the mother's health. (latimes.com)
  • Thick blood can obstruct the movement of oxygen, hormones, and nutrients in the body, preventing them from reaching tissues and cells. (medicalnewstoday.com)
  • Heme helps red blood cells (RBCs) carry oxygen and also gives RBCs their color. (healthline.com)
  • B-domain deleted recombinant Factor VIII , Fc fusion protein ( BDD -rFVIIIFc) is the active ingredient in ELOCTATE. (rxlist.com)
  • BDD-rFVIIIFc is a recombinant protein consisting of a B-domain deleted analogue of human Coagulation Factor VIII covalently linked to the human immunoglobulin G1 (IgG1) Fc domain sequence. (rxlist.com)
  • RATIONALE: Umbilical cord blood transplantation may be able to replace cells destroyed by chemotherapy or radiation therapy. (bioportfolio.com)
  • A lack of iron can affect your body's ability to make red blood cells. (uwmedicine.org)
  • This enzyme helps red blood cells work properly. (uwmedicine.org)
  • This is when the red blood cells break down faster than they are made. (uwmedicine.org)
  • The destruction of red blood cells is called hemolysis. (uwmedicine.org)
  • Having fewer white blood cells makes you more likely to get an infection. (uwmedicine.org)
  • Pancytopenia is a broader term which means a shortage of all three types of normal blood cells. (uwmedicine.org)
  • Looks at the number and types of cells in your blood. (hopkinsmedicine.org)
  • This is a rare and serious condition in which the child's body stops producing new blood cells. (uhhospitals.org)
  • This disease occurs when there is an overproduction of a type of white blood cells called histiocytes. (uhhospitals.org)
  • The syndromes occur when something stops new blood cells, which are produced in the blood marrow, from maturing. (uhhospitals.org)
  • CBC (complete blood count) provides information regarding red blood cells, white blood cells, and platelet count. (medindia.net)
  • Hemolysis, the breakdown of red blood cells, is a characteristic feature of HELLP syndrome. (medindia.net)
  • Plaques are deposits of beta amyloid protein that accumulate in the spaces between nerve cells in the brain, interfering the the cells' ability to communicate with each other. (highlighthealth.com)
  • M - monoclonal gammopathy or monoclonal plasma proliferative disorder: a collection of abnormal blood protein cells. (aapc.com)
  • The formation of these fibers stiffens the red blood cells and can change the shape from disc-shaped to crescent, or sickle, shape. (eurekalert.org)
  • Polycythemia vera (PV) is a blood cancer originating in the bone marrow or soft center of the bone where new blood cells develop. (medicalnewstoday.com)
  • In some people with WM, when the cancerous B cells make too much of this protein, the blood can become extremely thick, leading to blood clots. (medicalnewstoday.com)
  • In iron deficiency, this value is low because the bone marrow is unable to manufacture red blood cells. (verywell.com)
  • Boulday G, Coulon F, Fraser CC, Soulillou JP, Charreau B. Transcriptional up-regulation of the signaling regulatory protein LNK in activated endothelial cells. (springer.com)
  • Expression of the adaptor protein Lnk in leukemia cells. (springer.com)
  • Red blood cells (RBC) (and ferritin, folate or vitamin B12) may be lowered in parasites, celiac and Crohn's disease. (healthhype.com)
  • White blood cells (WBC) are usually elevated in gastrointestinal infection or inflammation. (healthhype.com)
  • When you're healthy, plasma cells (a type of white blood cell) in your body's bone marrow help your body fight infections by producing antibodies that find and attack germs. (healthline.com)
  • Your bone marrow is a soft tissue found inside most of your bones that produces blood cells. (healthline.com)
  • Sometimes, the plasma cells create abnormal proteins. (healthline.com)
  • These cancerous plasma cells begin to outnumber healthy blood-forming cells in the bone marrow. (healthline.com)
  • Abnormal plasma cells produce M proteins in the blood that are exactly the same. (healthline.com)
  • In mutant cells, the protein phosphotransferase (green) is spread beyond the Golgi (red). (newswise.com)
  • There is a lot of interest and study about how cells distribute proteins to the right parts of the cell," said senior author Stuart A. Kornfeld, MD, PhD, the David C. and Betty Farrell Professor of Medicine. (newswise.com)
  • The substance, a small protein, was found in cells grown from a human colon cancer. (orlandosentinel.com)
  • Sometimes, young red blood cells (reticulocytes) are also checked. (stlouischildrens.org)
  • Nathans adds, "We now know that endothelial cells that make up the blood-brain barrier have to receive signals constantly from nearby brain or retinal cells telling them, 'You're in the brain. (redorbit.com)
  • The "windows" in the other endothelial cells in the body are protein portals that allow large molecules to pass through easily - to be filtered by the kidneys, for example. (redorbit.com)
  • This reinforcement of the endothelial cells is what is known as the blood-brain barrier. (redorbit.com)
  • Here, we applied proteomics, expression analysis and functional studies in primary murine ATII cells to identify proteins and molecular mechanisms involved in alveolar epithelial plasticity. (biologists.org)
  • Mass spectrometry of cultured ATII cells revealed a reduction of carbonyl reductase 2 (CBR2) and an increase in enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) protein expression during ATII-to-ATI cell trans-differentiation. (biologists.org)
  • an ATI cell marker), exhibited decreased protein expression upon pharmacological and molecular Wnt/β-catenin inhibition in cultured ATII cells, whereas CBR2 levels were stabilized. (biologists.org)
  • We observed reduced CBR2 significantly correlating with surfactant protein C (SFTPC), whereas ENO1 and PDIA3 along with T1α were increased in injured ATII cells. (biologists.org)
  • ATII cells are involved in ion transport and liquid homeostasis ( Fehrenbach, 2001 ) but, most importantly, ATII cells are responsible for the production, storage, secretion and recycling of pulmonary surfactant, a complex mixture of lipids and proteins, lining the alveolar epithelium. (biologists.org)
  • Pyrin, the familial Mediterranean fever protein, is found in association with the cytoskeleton in myeloid/monocytic cells and modulates IL-1β processing, NF-κB activation, and apoptosis. (pnas.org)
  • Sickle cell disease (SCD) is a common name for several inherited disorders that affect red blood cells. (health24.com)
  • These irregular-shaped blood cells die early, causing a shortage of red blood cells. (health24.com)
  • This is because the "sickled" red blood cells are somewhat resistant to infection by the malaria parasite. (health24.com)
  • SCD carriers retain some of this resistance to malaria because some of their red blood cells are abnormal. (health24.com)
  • Ferritin has adaptive and reactive properties to contribute to normal homeostasis or balance in the body, therefore people with autoimmune disorders, some types of cancer, chronic infection and inflammation may have higher than normal ferritin levels. (brighthub.com)
  • We hear a lot about autoimmune disorders but what exactly is an autoimmune disorder? (directlabs.com)
  • [ 7 ] These mutations are divided into 2 types-type I and type II-on the basis of whether they cause a quantitative (type I) or functional (type II) deficiency of protein C. (medscape.com)
  • Waldenstrom macroglobulinemia (WM) is a rare type of non-Hodgkin lymphoma where large amounts of the protein macroglobulin are produced. (medicalnewstoday.com)
  • For example, smoking, plaque on the inside of the arteries (atherosclerosis), and birth control pills can increase the risk of excessive blood clots. (fertilityauthority.com)
  • These lifelong rare blood disorders are triggered by genetic mutations. (sanofi.com)
  • Recently, PSTPIP1/CD2BP1 mutations were shown to cause the syndrome of pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA), a dominantly inherited autoinflammatory disorder mediated predominantly by granulocytes. (pnas.org)
  • Consistent with the hypothesis that these mutations exert a dominant-negative effect on the previously reported activity of pyrin, we found increased IL-1β production by peripheral blood leukocytes from a clinically active PAPA patient with the A230T PSTPIP1/CD2BP1 mutation and in cell lines transfected with both PAPA-associated mutants. (pnas.org)
  • Eighteen spots were identified by 2-D gel electrophoresis (2DGE), a technique used to separate and identify proteins. (highlighthealth.com)
  • Our pediatric hematologists and other blood disorder specialists emphasize the prevention of long-term complications. (uhhospitals.org)
  • For example, everyone has "good" bacteria that aids in digestion of food but a person with an autoimmune disorder would suffer attacks from their body on that good bacteria, causing all types of complications. (directlabs.com)
  • Mild cases can be helped by bed rest, but there is no effective treatment for the disorder other than delivery of the infant and removal of the placenta. (latimes.com)
  • In pre-eclampsia the blood flow to the placenta becomes sluggish. (cyh.com)
  • A World Health Organization team is organizing a test of the proteins' predictive value among pregnant women in the Third World, and Fremont, Calif.-based biotech company Scios Inc. is looking for funding to test a potential treatment. (latimes.com)