Blood Platelets
Platelet Aggregation
Platelet Adhesiveness
Platelet Membrane Glycoproteins
Platelet Factor 4
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
Adenosine Diphosphate
Platelet Transfusion
Serotonin
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Platelet Glycoprotein GPIIb-IIIa Complex
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Platelet Glycoprotein GPIb-IX Complex
Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.
beta-Thromboglobulin
A platelet-specific protein which is released when platelets aggregate. Elevated plasma levels have been reported after deep venous thrombosis, pre-eclampsia, myocardial infarction with mural thrombosis, and myeloproliferative disorders. Measurement of beta-thromboglobulin in biological fluids by radioimmunoassay is used for the diagnosis and assessment of progress of thromboembolic disorders.
Platelet Activation
Platelet Activating Factor
Platelet Function Tests
Fibrinogen
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Prostanoic Acids
P-Selectin
von Willebrand Factor
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
Aspirin
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Thrombopoiesis
Collagen
Blood Cell Count
Thromboxane A2
Blood Coagulation
Hemostasis
Antigens, Human Platelet
Thrombopoietin
Rabbits
Alphaprodine
An opioid analgesic chemically related to and with an action resembling that of MEPERIDINE, but more rapid in onset and of shorter duration. It has been used in obstetrics, as pre-operative medication, for minor surgical procedures, and for dental procedures. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1067)
Thromboxanes
Physiologically active compounds found in many organs of the body. They are formed in vivo from the prostaglandin endoperoxides and cause platelet aggregation, contraction of arteries, and other biological effects. Thromboxanes are important mediators of the actions of polyunsaturated fatty acids transformed by cyclooxygenase.
Ergoloid Mesylates
A mixture of the mesylates (methane sulfonates) of DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and the alpha- and beta-isomers of DIHYDROERGOCRYPTINE. The substance produces a generalized peripheral vasodilation and a fall in arterial pressure and has been used to treat symptoms of mild to moderate impairment of mental function in the elderly.
Mopidamol
Blood Preservation
Photinia
Bleeding Time
Ergotamine
Iprindole
Receptors, Thromboxane
Blood Proteins
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Epinephrine
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Platelet Membrane Glycoprotein IIb
Platelet membrane glycoprotein IIb is an integrin alpha subunit that heterodimerizes with INTEGRIN BETA3 to form PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX. It is synthesized as a single polypeptide chain which is then postranslationally cleaved and processed into two disulfide-linked subunits of approximately 18 and 110 kDa in size.
Epoprostenol
Cell Membrane
Platelet Factor 3
Imipramine
Microscopy, Electron
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Organoids
Blood Coagulation Disorders
Cytoskeleton
Adenosine Triphosphate
Platelet Aggregation Inhibitors
Prostaglandins
Calcimycin
An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.
Arachidonic Acid
An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.
Receptors, Thrombopoietin
Edetic Acid
Methysergide
An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.
Immunochemistry
Receptors, Purinergic P2Y12
Receptors, Prostaglandin
Cell surface receptors that bind prostaglandins with high affinity and trigger intracellular changes which influence the behavior of cells. Prostaglandin receptor subtypes have been tentatively named according to their relative affinities for the endogenous prostaglandins. They include those which prefer prostaglandin D2 (DP receptors), prostaglandin E2 (EP1, EP2, and EP3 receptors), prostaglandin F2-alpha (FP receptors), and prostacyclin (IP receptors).
Platelet Storage Pool Deficiency
Heparin
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Ristocetin
Electrophoresis, Polyacrylamide Gel
Thrombasthenia
A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and impaired or absent clot retraction. Platelet membranes are deficient in or have a defect in the glycoprotein IIb-IIIa complex (PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX).
Dose-Response Relationship, Drug
Actinin
Purpura, Thrombocytopenic
Glycoproteins
Binding, Competitive
Actins
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
Pseudopodia
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Phosphorylation
Crotalid Venoms
Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.
Reserpine
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
Endothelium
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Microscopy, Electron, Scanning
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Protein Binding
Peptide Fragments
Blood Coagulation Factors
Platelet-Rich Plasma
Thromboxane B2
Cells, Cultured
Amino Acid Sequence
Prostaglandin Endoperoxides, Synthetic
Alkaloids
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Leukocyte Count
Erythrocytes
Endothelium, Vascular
Carbon Isotopes
Chromatography, High Pressure Liquid
Membrane Proteins
Phospholipids
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Hematopoiesis
Bernard-Soulier Syndrome
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Dimethyl Sulfoxide
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.
Stress, Mechanical
Receptors, Thrombin
A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.
Dogs
Chromatography, Affinity
Chromatography, Gel
Binding Sites
Serotonin Antagonists
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Plateletpheresis
Apyrase
Immunoglobulin Fab Fragments
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Indium
Microtubules
Receptors, Collagen
Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI.
Receptors, Drug
Hemorheology
Cytoplasm
Enzyme Activation
Models, Biological
Hydrogen-Ion Concentration
Purpura, Thrombocytopenic, Idiopathic
Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.
Thrombospondins
A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.
Gray Platelet Syndrome
Values of three coagulation screening tests of precolostral calves. (1/11030)
Prothrombin times, partial thromboplastin times and platelet counts were performed to determine normal values and to screen for coagulation defects of precolostral calves. The precolostral calves were in two groups: one group of a few calves was tested two years before the second larger group. The results for both groups were similar. The tests were performed on postcolostral calves and on mature cows to compare their values with those of precolostral calves. The mean values of prothrombin times and partial thromboplastin times of precolostral calves in the first group were 18.8 seconds and 54.8 seconds respectively. The mean values of prothrombin times and partial thromboplastin times of precolostral calves in the second group were 18.8 seconds and 50.8 seconds respectively. The mean platelet count was 422,400/cmm for the first group and 482,800/cmm for the second group. (+info)Enhanced myocardial glucose use in patients with a deficiency in long-chain fatty acid transport (CD36 deficiency). (2/11030)
CD36 is a multifunctional, 88 kDa glycoprotein that is expressed on platelets and monocytes/macrophages. CD36 also has high homology with the long-chain fatty acid (LFA) transporter in the myocardium. Although platelet and monocyte CD36 levels can indicate a CD36 deficiency, they cannot predict specific clinical manifestations in the myocardium of a given person. We examined the hypothesis that a deficiency in LFA transport augments myocardial glucose uptake in patients with a type I CD36 deficiency. METHODS: Seven fasting patients with a type I CD36 deficiency and 9 controls were assessed by cardiac radionuclide imaging using beta-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) as a LFA tracer and by PET with 18F-fluorodeoxyglucose (FDG). RESULTS: None of the patients with a CD36 deficiency showed myocardial uptake of BMIPP. The percentage dose uptake of BMIPP in these subjects was significantly lower than that in normal controls (1.31+/-0.24 versus 2.90+/-0.2; P < 0.005). PET studies revealed that myocardial FDG accumulation was substantially increased in patients with a CD36 deficiency. Quantitative analysis showed that the percentage dose uptake of FDG in patients with a CD36 deficiency was significantly higher than that in normal controls (1.28+/-0.35 versus 0.43+/-0.22; P< 0.01). CONCLUSION: CD36 functions as a major myocardial LFA transporter and its absence may cause a compensatory upregulation of myocardial glucose uptake. (+info)Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. (3/11030)
Collagen-related peptide (CRP), a collagen homologue, induces platelet activation through a tyrosine kinase-dependent pathway, leading to sequential tyrosine phosphorylation of Fc receptor (FcR) gamma-chain, Syk, and phospholipase C-gamma2. Here we report that CRP and the platelet low affinity immune receptor FcgammaRIIA stimulate tyrosine phosphorylation of the T cell adapter SLP-76, whereas the G protein-coupled receptor agonist thrombin induces only minor tyrosine phosphorylation. This suggests that SLP-76 has a specific role downstream of receptors that signal via an immunoreceptor tyrosine-based activation motif. Immunoprecipitation studies demonstrate association of SLP-76 with SLAP-130, Vav, Fyn, Lyn, and the FcR gamma-chain in CRP-stimulated platelets. Several of these proteins, including SLP-76, undergo tyrosine phosphorylation in in vitro kinase assays performed on SLP-76 immunoprecipitates. Tyrosine phosphorylation of all of these proteins in the in vitro kinase assay was abrogated by the Src family kinase inhibitor PP1, suggesting that it is mediated by either Fyn or Lyn. The physiological significance of this is uncertain, however, since tyrosine phosphorylation of SLP-76 in vivo is not altered in either Fyn- or Lyn-deficient platelets. CRP stimulation of Syk-deficient platelets demonstrated that in vivo tyrosine phosphorylation of SLP-76 is downstream of Syk. The absence of Syk in the SLP-76 immunoprecipitates raises the possibility that another protein is responsible for bringing SLP-76 to Syk. Candidates for this include those proteins that co-immunoprecipitate with SLP-76, including the FcR gamma-chain. Tyrosine phosphorylation of PLC-gamma2 and Ca2+ mobilization is markedly attenuated in SLP-76-deficient platelets following CRP stimulation, suggesting that the adapter plays a critical role in the regulation of the phospholipase. The increase in tyrosine phosphorylation of SLAP-130 in response to CRP is also inhibited in SLP-76-deficient platelets, placing it downstream of SLP-76. This work identifies SLP-76 as an important adapter molecule that is regulated by Syk and lies upstream of SLAP-130 and PLC-gamma2 in CRP-stimulated platelets. (+info)Changes in haematological parameters and iron metabolism associated with a 1600 kilometre ultramarathon. (4/11030)
OBJECTIVE: To investigate haematological variations and iron related changes in the serum of participants in a 1600 kilometre ultramarathon run. PARTICIPANTS: Seven male and two female participants in a 1600 km foot race. METHODS: Blood samples were obtained from the participants before, after four and 11 days of running, and at the end of the event. Samples were analysed by standard methods for haemoglobin, packed cell volume, total red cell count, mean red cell volume, mean red cell haemoglobin, total white cell count and differential, platelets, reticulocytes, iron, ferritin, total iron binding capacity, percentage transferrin saturation, haptoglobin, and bilirubin and corrected for changes in plasma volume. RESULTS: The following variables decreased during the event (p < 0.05): haemoglobin, packed cell volume, mean red cell volume, percentage lymphocytes, percentage monocytes, serum iron, total iron binding capacity, and percentage transferrin saturation. Increases (p < 0.05) were found in plasma volume, total red cell count (day 4 only), total white cell count, percentage and absolute numbers of neutrophils and reticulocytes, absolute numbers of lymphocytes and monocytes (day 4 only), absolute numbers of eosinophils (day 11 and race end), absolute numbers of basophils (race end only), platelets, ferritin, haptoglobin, and bilirubin (day 4 only). CONCLUSION: Ultramarathon running is associated with a wide range of changes in haematological parameters, many of which are related to the normal acute phase response to injury. These should not be confused with indicators of disease. (+info)The Megakaryocyte/Platelet-specific enhancer of the alpha2beta1 integrin gene: two tandem AP1 sites and the mitogen-activated protein kinase signaling cascade. (5/11030)
The alpha2beta1 integrin, a collagen receptor on platelets and megakaryocytes, is required for normal platelet function. Transcriptional regulation of the alpha2 integrin gene in cells undergoing megakaryocytic differentiation requires a core promoter between bp -30 and -92, a silencer between bp -92 and -351, and megakaryocytic enhancers in the distal 5' flank. We have now identified a 229-bp region of the distal 5' flank of the alpha2 integrin gene required for high-level enhancer activity in cells with megakaryocytic features. Two tandem AP1 binding sites with dyad symmetry are required for enhancer activity and for DNA-protein complex formation with members of the c-fos/c-jun family. The requirement for AP1 activation suggested a role for the mitogen-activated protein kinase (MAPK) signaling pathway in regulating alpha2 integrin gene expression. Inhibition of the MAP kinase cascade with PD98059, a specific inhibitor of MAPK kinase 1, prevented the expression of the alpha2 integrin subunit in cells induced to become megakaryocytic. We provide a model of megakaryocytic differentiation in which expression of the alpha2 integrin gene requires signaling via the MAP kinase pathway to activate two tandem AP1 binding sites in the alpha2 integrin enhancer. (+info)Activation of stimulus-specific serine esterases (proteases) in the initiation of platelet secretion. I. Demonstration with organophosphorus inhibitors. (6/11030)
The effect of organophosphorus inhibitors of serine esterases (proteases) on secretion from washed rabbit platelets was examined. Five noncytotoxic stimuli were employed: collagen, thrombin, heterologous anti-platelet antibody (in the absence of complement), rabbit C3 bound to zymosan, and platelet activating factor derived from antigen-stimulated, IgE-sensitized rabbit basophils. Diisoprophyl phosphofluoridate, three series of p-nitrophenyl ethyl phosphonates, and a series of cyclohexyl phenylalkylphosphonofluridates were all found to be inhibitory to the platelet secretion. These are irreversible inhibitors of serine proteases but in this system were only inhibitory if added to the platelets concurrently with the stimuli. Pretreatment of either the platelets or the stimuli with the inhibitors followed by washing, was without effect on the subsequent reaction. This suggested the involvement of stimulus-activatable serine proteases in the secretory process. The concept was supported by finding that nonphosphorylating phosphonates or hydrolyzed phosphonates or phosphonofluoridates were without inhibitory action. The effect of a series of phosphonates or phosphonoflouridates in inhibiting each stimulus exhibited a unique activity-structure profile. The demonstration of such unique profiles with four series of inhibitors for each of the five stimuli was interpreted as demonstrating that a specific activatable serine protease was involved in the platelet secretory response to each stimulus. (+info)Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPib/actin-binding protein (ABP-280) interaction in maintaining adhesion under high shear. (7/11030)
Adhesion of platelets to sites of vascular injury is critical for hemostasis and thrombosis and is dependent on the binding of the vascular adhesive protein von Willebrand factor (vWf) to the glycoprotein (GP) Ib-V-IX complex on the platelet surface. A unique but poorly defined characteristic of this receptor/ligand interaction is its ability to support platelet adhesion under conditions of high shear stress. To examine the structural domains of the GPIb-V-IX complex involved in mediating cell adhesion under flow, we have expressed partial (GPIb-IX), complete (GPIb-V-IX), and mutant (GPIbalpha cytoplasmic tail mutants) receptor complexes on the surface of Chinese hamster ovary (CHO) cells and examined their ability to adhere to a vWf matrix in flow-based adhesion assays. Our studies demonstrate that the partial receptor complex (GPIb-IX) supports CHO cell tethering and rolling on a bovine or human vWf matrix under flow. The adhesion was specifically inhibited by an anti-GPIbalpha blocking antibody (AK2) and was not observed with CHO cells expressing GPIbbeta and GPIX alone. The velocity of rolling was dependent on the level of shear stress, receptor density, and matrix concentration and was not altered by the presence of GPV. In contrast to selectins, which mediate cell rolling under conditions of low shear (20-200 s-1), GPIb-IX was able to support cell rolling at both venous (150 s-1) and arterial (1500-10,500 s-1) shear rates. Studies with a mutant GPIbalpha receptor subunit lacking the binding domain for actin-binding protein demonstrated that the association of the receptor complex with the membrane skeleton is not essential for cell tethering or rolling under low shear conditions, but is critical for maintaining adhesion at high shear rates (3000-6000 s-1). These studies demonstrate that the GPIb-IX complex is sufficient to mediate cell rolling on a vWf matrix at both venous and arterial levels of shear independent of other platelet adhesion receptors. Furthermore, our results suggest that the association between GPIbalpha and actin-binding protein plays an important role in enabling cells to remain tethered to a vWf matrix under conditions of high shear stress. (+info)Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. (8/11030)
Platelets respond to various stimuli with rapid changes in shape followed by aggregation and secretion of their granule contents. Platelets lacking the alpha-subunit of the heterotrimeric G protein Gq do not aggregate and degranulate but still undergo shape change after activation through thromboxane-A2 (TXA2) or thrombin receptors. In contrast to thrombin, the TXA2 mimetic U46619 led to the selective activation of G12 and G13 in Galphaq-deficient platelets indicating that these G proteins mediate TXA2 receptor-induced shape change. TXA2 receptor-mediated activation of G12/G13 resulted in tyrosine phosphorylation of pp72(syk) and stimulation of pp60(c-src) as well as in phosphorylation of myosin light chain (MLC) in Galphaq-deficient platelets. Both MLC phosphorylation and shape change induced through G12/G13 in the absence of Galphaq were inhibited by the C3 exoenzyme from Clostridium botulinum, by the Rho-kinase inhibitor Y-27632 and by cAMP-analogue Sp-5,6-DCl-cBIMPS. These data indicate that G12/G13 couple receptors to tyrosine kinases as well as to the Rho/Rho-kinase-mediated regulation of MLC phosphorylation. We provide evidence that G12/G13-mediated Rho/Rho-kinase-dependent regulation of MLC phosphorylation participates in receptor-induced platelet shape change. (+info)
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JCI -
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THE PRODUCTION OF BLOOD PLATELETS IN THE LUNGS | JEM
Blood Platelets Can Kill Malaria Parasites | WebWire
SOLUTION: Medicine an Surgery notes - Studypool
Platelet reactivity and endothelial function in children of patients with early acute myocardial infarction
Platelets harbor prostate cancer biomarkers and the ability to predict therapeutic response to abiraterone in castration...
About: Platelet
Platelet receptors and signaling in the dynamics of thrombus formation
| Haematologica
Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy
Preferential binding of platelets to monocytes over neutrophils under flow<...
Intravenous (IV) anti-D and IV immunoglobulin achieve acute platelet increases by different mechanisms: modulation of cytokine...
Tortuosity Triggers Platelet Activation and Thrombus Formation in Microvessels | Journal of Biomechanical Engineering | ASME DC
A Sticky Story for Signal Transducer and Activator of Transcription 3 in Platelets | Circulation
Abstract WP439: Mean Platelet Volume and Platelet Count are not Associated With Coated-Platelet Levels Among Patients With...
Isnip.net :: How To Increase Blood Platelet Levels
A study of whole blood platelet and white cell aggregation using a laser flow aggregometer<...
Comparison of different platelet transfusion thresholds prior to insertion of central lines in patients with thrombocytopenia -...
Cytoskeletal Mechanics of Proplatelet Maturation and Platelet Release
S-EPMC6055520 - A whole blood model of thrombocytopenia that controls platelet count and hematocrit. - OmicsDI
Functional alterations of human platelets following <sup>111</sup>In labeling with different ligands and incubation...
Flow cytometric evaluation of platelet activation in blood collected into EDTA vs. Diatube-H, a sodium citrate solution...
Mechanisms Underlying the Morning Increase in Platelet Aggregation: A Flow Cytometry Study | JACC: Journal of the American...
Streptococcus mitis Phage-Encoded Adhesins Mediate Attachment to α2-8-Linked Sialic Acid Residues on Platelet Membrane...
Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with...
Platelet Life Span: 10 Incredibly Influential Factors | Thrombocytes
Acquired Qualitative Platelet Disorders | Williams Hematology, 9e | AccessHemOnc | McGraw-Hill Medical
Diet To Increase Platelets | | Fitnesstale
What do low blood platelets indicate | www.QACollections.com
The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and...
Platelet gene therapy improves hemostatic function for integrin αIIbβ3-deficient dogs
The Landscape of Coding and Noncoding RNAs in Platelets - Research Portal, Kings College, London
Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets...
Activation of phosphatidylinositol 3-kinase ß by the platelet collagen receptors integrin a2ß1 and GPVI: The role of Pyk2 and c...
Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y<sub>12</sub> signaling with...
Serotonin uptake rates in platelets from angiotensin II-induced hypertensive mice
Role of hypoxia on platelet function in patients with chronic obstructive pulmonary disease | International Journal of Current...
Serotonin uptake rates in platelets from angiotensin II-induced hypertensive mice
Cloning of porcine platelet glycoprotein Iba and comparison with the human homolog
AID 336312 - Antiplatelet activity against bovine citreated platelet assessed as inhibition of ADP-induced platelet aggregation...
Extensive characterization of the composition and functional activities of five preparations of human platelet lysates for...
To delineate the critical top features of platelets necessary for balance | ATR inhibitors VE-821 and VX-970 sensitize cancer...
Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by...
British Library EThOS: Modulation of platelet activity by S. aureus lipoproteins
On the Easy Bruising Syndrome with Normal Platelet CountA Study of 75 Patients | Annals of Internal Medicine | American...
POPULATION BALANCE ANALYSIS OF SHEAR-INDUCED PLATELET AGGREGATION
Platelet adhesion and prevention at blood-polymer interface. - Semantic Scholar
Effects of Nd:YAG laser-heated metal cap on human platelets in vitro | (1993) | Liu | Publications | Spie
Involvement of cyclooxygenase, phospholipase C and MAP kinase pathways in human platelet aggregation mediated by the...
Exposure of human megakaryocytes to high shear rates accelerates platelet production | Blood | American Society of Hematology
Platelet Rich Plasma (PRP) Market Worldwide Prospects, Share, Crucial Players, Size & Forecast - 2028 - PharmiWeb.com
Platelets | Platelets Count | Low Platelets | Normal Platelets
Antithymocyte Globulin-Induced Platelet Hypercoagulability Is a Consequence of Complement Activation and Microvesicle Release -...
Adenosine diphosphate
Blood platelet activation[edit]. Under normal conditions, small disk-shape platelets circulate in the blood freely and without ... ADP is stored in dense bodies inside blood platelets and is released upon platelet activation. ADP interacts with a family of ... ADP in the blood is converted to adenosine by the action of ecto-ADPases, inhibiting further platelet activation via adenosine ... P2Y1 receptors initiate platelet aggregation and shape change as a result of interactions with ADP. ...
WASF3
2005). "WAVE/Scars in platelets". Blood. 105 (8): 3141-8. doi:10.1182/blood-2003-04-1319. PMID 15280206. Kashiwagi H, Shiraga M ... 2005). "Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage". J. Thromb. Haemost. 3 ...
Sphingosine kinase
Stoffel W, Heimann G, Hellenbroich B (1973). "Sphingosine kinase in blood platelets". Hoppe-Seyler's Z. Physiol. Chem. 354 (5 ...
12-Hydroxyeicosatetraenoic acid
Nugteren, D. H. (1975). "Arachidonate lipoxygenase in blood platelets". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid ... Sub-primate mammals, such as the mouse, rat, rabbit, cow, and pig, express platelet type 12-lipoxygenase but also a leukocyte ... It was first found as a product of arachidonic acid metabolism made by human and bovine platelets through their 12S- ... Thus, the production of hepoxilins from 12(S)-HpETE may result from the intrinsic activity of platelet or leukocyte type 12- ...
ALOX12
Based predominantly on the presence of its mRNA, human ALOX12 is distributed predominantly in blood platelets and leukocytes ... Nugteren DH (February 1975). "Arachidonate lipoxygenase in blood platelets". Biochimica et Biophysica Acta (BBA) - Lipids and ... "Immunocytochemical localization of platelet-type arachidonate 12-lipoxygenase in mouse blood cells". The Journal of ... regulate regional blood flow, and contribute to the regulation of blood pressure in animal models (see Hepoxilins). Far more ...
Fibrin
When the lining of a blood vessel is broken, platelets are attracted, forming a platelet plug. These platelets have thrombin ... Blood platelets: biochemistry and physiology]". Hamostaseologie (in German). 23 (4): 149-58. doi:10.1055/s-0037-1619592. PMID ... the blockage of a vessel by an agglutination of red blood cells, platelets, polymerized fibrin and other components. ... TGW1916.net, Defibrinated blood harvested from sheep (video) Fibrin: Molecule of the Month, by David Goodsell, RCSB Protein ...
1910 in science
Wright, J. H. (1910). "The histogenesis of blood platelets". Journal of Morphology. 21 (2): 263-78. doi:10.1002/jmor.1050210204 ... Platelets are first named by James Homer Wright. Peyton Rous demonstrates that a malignant tumor can be transmitted by a virus ... Chicago cardiologist James B. Herrick makes the first published identification of sickle cells in the blood of a patient ... Herrick, James B. (November 1910). "Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia". ...
Tachykinin receptor 3
"Tachykinins regulate the function of platelets". Blood. 104 (4): 1058-65. doi:10.1182/blood-2003-11-3979. PMID 15130944. Page ...
Vesicular monoamine transporter
It is also expressed blood platelets. VMAT2 is also co-expressed in chromaffin cells. Expression of the two transporters in ... Activated heterotrimeric G-protein Gαq downregulates VMAT2 mediated serotonin transport in blood platelets, but this is not the ... May 2003). "The vesicular monoamine content regulates VMAT2 activity through Galphaq in mouse platelets. Evidence for ...
Georges Hayem
First accurate counts of blood platelets. Traitement du choléra, G. Masson, Paris, 1885 - Treatment of cholera. Du sang et ses ... He performed the first accurate count of blood platelets, and is credited with developing a solution of mercury bichloride, ... Lecons cliniques sur les maladies du sang, G. Masson, Paris, 1900 - Clinical lessons on blood disorders. L'hématoblaste, ... sodium chloride and sodium sulfate for dilution of blood prior to counting erythrocytes with a hemocytometer. In 1874 he ...
Copper deficiency
Thrombocytopenia (low blood platelets) is unusual. The peripheral blood and bone marrow aspirate findings in copper deficiency ... Bone marrow aspirate in both conditions may show dysplasia of blood cell precursors and the presence of ring sideroblasts ( ... Copper deficiency can have many hematological consequences, such as myelodysplasia, anemia, low white blood cell count, and low ... when a blood profile has indicators of possible future leukemia development), but it was not until 2001 that copper deficiency ...
Eicosanoid
blood platelet aggregation; blood clotting; allergic reactions. NSAIDs inhibit its production to reduce incidence of strokes ... The blood vessels engorge and the injury reddens.. Swelling-LTB4 makes the blood vessels more permeable. Plasma leaks out into ... and other blood vessels as well as on the kidney's reabsorption of sodium and water, and act to reduce blood pressure and ... blood flow to tissues, and/or blood pressure. However, their function and relevancy to human physiology and pathology have not ...
Transient myeloproliferative disease
Megakaryocytes release platelets into the bloodstream. Platelets are critical for normal blood clotting. In consequence of this ... Blood samples are obtained from the fetal umbilical cord to determine blood cell counts, measure blood enzymes to evaluate ... decreased numbers of circulating platelets and red blood cells, and increased numbers of circulating white blood cells. Also ... reduced platelet production often accompanied by significantly reduced levels of circulating platelets; reduced red blood cell ...
Thomas P. Stossel
Preservation of Blood Platelets. US Patent Number 5,876,676, issued March 2, 1999. 7. Stossel, TP, Hartwig, JH, Hoffmeister, KM ... Effect of corticosteriod therapy on the phagocytosis of antibody-coated platelets by human leukocytes. Blood. 1978; 51:771-779 ... The clearance mechanism of chilled blood platelets. 2003. Cell, 112: 87-97. 126. Hoffmeister, KM, Josefsson, EC, Isaac, NA, ... Glycosylation restores survival of chilled blood platelets. 2003. Science 301: 1532-1534. 127. Woo, MS, Ohta, Y, Rabinovitz, I ...
Transfusion-associated graft versus host disease
The blood components are from a family donor. HLA-matched platelets are transferred. Another means of prevention is the use of ... Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare complication of blood transfusion, in which the donor T ... The incidence of TA-GvHD in immunocompromised patients receiving blood transfusions is estimated to be 0.1 - 1.0%, and ... Prevention includes gamma irradiation of the lymphocyte-containing blood products. This procedure should be performed in ...
X linked thrombocytopenia
... specifically the platelets in the blood. Platelets are cell fragments in the blood that aid in clotting. Platelets are produced ... Normal platelet counts range from 150,000 to 450,000 platelets per µL of blood. Individuals with XLT usually have drastically ... reduced platelet counts, typically less than 70,000 platelets per µL of blood. Not only are there fewer platelets circulating, ... but individuals with XLT also have smaller platelets. Fewer and smaller platelets causes the efficacy of the clotting mechanism ...
Anagrelide
... or overproduction of blood platelets. It also has been used in the treatment of chronic myeloid leukemia. Anagrelide controlled ... Anagrelide works by inhibiting the maturation of platelets from megakaryocytes. The exact mechanism of action is unclear, ... age over 60 years platelet count over 1000×109/L a history of thrombosis According to a 2005 Medical Research Council ...
Deep vein thrombosis
Fresh venous clots are red blood cell and fibrin rich. Platelets and white blood cells are also components. Platelets are not ... Individuals without O blood type have higher blood levels of von Willebrand factor and factor VIII than those with O blood type ... NETs provide "a scaffold for adhesion" of platelets, red blood cells, and multiple factors that potentiate platelet activation ... Blood has a natural tendency to clot when blood vessels are damaged (hemostasis) to minimize blood loss. Clotting is activated ...
CD109
1990). "Gova/b alloantigen system on human platelets". Blood. 75 (11): 2172-6. doi:10.1182/blood.V75.11.2172.2172. PMID 2346781 ... 1991). "Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets". Blood. 77 ( ... 2002). "A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens". Blood. 99 (5): 1692-8. doi:10.1182/ ... and activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system (HPA15), implicated in ...
Eli Moschcowitz
Her blood vessels were largely filled with platelets. Modern reports still occasionally refer to TTP as "Moschcowitz disease" ...
Monoamine oxidase
MAO-B is mostly found in blood platelets. MAO-A appears at roughly 80% of adulthood levels at birth, increasing very slightly ... Domino EF, Khanna SS (March 1976). "Decreased blood platelet MAO activity in unmedicated chronic schizophrenic patients". The ... Schildkraut JJ, Herzog JM, Orsulak PJ, Edelman SE, Shein HM, Frazier SH (April 1976). "Reduced platelet monoamine oxidase ... Oreland L (January 2004). "Platelet monoamine oxidase, personality and alcoholism: the rise, fall and resurrection". ...
Helge Stormorken
Thaulow, E; Erikssen, J; Sandvik, L; Stormorken, H; Cohn, PF (August 1991). "Blood platelet count and function are related to ... Holmsen, H; Day, HJ; Stormorken, H (1969). "The blood platelet release reaction". Scandinavian Journal of Haematology. ... Gogstad, GO; Stormorken, H; Solum, NO (15 July 1983). "Platelet alpha 2-antiplasmin is located in the platelet alpha-granules ... Day, HJ; Stormorken, H; Holmsen, H (1973). "Subcellular localization of platelet factor 3 and platelet factor 4". Scandinavian ...
Asim Duttaroy
Duttaroy, Asim K. (June 2018). Human Blood Platelet Function: Applications in Cardiovascular Health. Wiley. pp. 1-300. ISBN 978 ... discovered that an extract from tomato had a positive effect in the prevention of blood platelet aggregation.[4][5][6] ... "Effects of antiplatelet components of tomato extract on platelet function in vitro and ex vivo: A time-course cannulation ...
Oral manifestations of systemic disease
Thrombocytopenia is a deficiency of platelets in the blood. It can present as red blood blisters in the mouth. Patients ... A heart attack is a blood vessel in the heart being constricted either by a blood clot or atherosclerosis formation. A heart ... High blood sugar can be detected by sampling saliva. Saliva sampling may be a non-invasive way to detect changes in the gut ... Sickle cell disease is a hereditary genetic condition that results in deformed red blood cells to be formed. Sickle patients ...
Propylthiouracil
A decrease in blood platelets (thrombocytopenia) also may occur. Since platelets are important for the clotting of blood, ... One possible side effect is agranulocytosis, a decrease of white blood cells in the blood. Symptoms and signs of ... Other severe side effects include liver problems and low blood cell counts. Use during pregnancy may harm the baby. ...
Dipak K. Dey
"Dey's personal website". Barthel, W.; Markwardt, F. (1975). "Aggregation of blood platelets by adrenaline and its uptake". ...
SH2B3
Shattil SJ, Newman PJ (September 2004). "Integrins: dynamic scaffolds for adhesion and signaling in platelets". Blood. 104 (6 ... Blood. 105 (12): 4604-12. doi:10.1182/blood-2004-10-4093. PMC 1894992. PMID 15705783. Gueller S, Hehn S, Nowak V, Gery S, Serve ... doi:10.1182/blood-2004-04-1257. PMID 15205259. He X, Li Y, Schembri-King J, Jakes S, Hayashi J (August 2000). "Identification ... As a result, it is involved in blood diseases, autoimmune disorders, and vascular disease. The SH2B3 gene also contains one of ...
Electric truck
Barthel, W.; Markwardt, F. (1975-10-15). "Aggregation of blood platelets by adrenaline and its uptake". Biochemical ...
Acute megakaryoblastic leukemia
... platelets, into the circulation. Platelets are critical for the normal clotting of blood. While malignant megakaryoblasts ... increased blast cells in blood and/or bone marrow, immunochemical evidence that these blast cells bear platelet line-specific ... Blood. 100 (7): 2292-302. doi:10.1182/blood-2002-04-1199. PMID 12239137. de Rooij JD, Masetti R, van den Heuvel-Eibrink MM, ... Blood. 127 (20): 2391-405. doi:10.1182/blood-2016-03-643544. PMID 27069254. Seewald L, Taub JW, Maloney KW, McCabe ER ( ...
Ebola
Blood products such as packed red blood cells, platelets, or fresh frozen plasma may also be used.[135] Other regulators of ... This may cause vomiting blood, coughing up of blood, or blood in stool.[32] Bleeding into the skin may create petechiae, ... Possible non-specific laboratory indicators of EVD include a low platelet count; an initially decreased white blood cell count ... Finding the virus, viral RNA, or antibodies in blood[1]. Differential diagnosis. Malaria, cholera, typhoid fever, meningitis, ...
Hematopoietic stem cell transplantation
Cord blood has a higher concentration of HSC than is normally found in adult blood. However, the small quantity of blood ... platelet and hemoglobin levels dip post-procedure, not returning to normal until after one month.[45] ... Umbilical cord blood[edit]. Umbilical cord blood is obtained when a mother donates her infant's umbilical cord and placenta ... Allogeneic cord blood is stored frozen at a cord blood bank because it is only obtainable at the time of childbirth. To ...
Afatinib
Platelet-derived growth factor (A, B, C, D). *Kinase inhibitors: Agerafenib. *Axitinib ... Low amount of potassium in the blood. *Conjunctivitis. *Increased ALT. *Increased AST ...
Lyme disease
... or who have abnormally low levels of white or red cells or platelets in the blood, should be investigated for possible ... and possibly testing for specific antibodies in the blood.[3][11] Blood tests are often negative in the early stages of the ... Based on symptoms, tick exposure, blood tests[3]. Prevention. Prevention of tick bites (clothing the limbs, DEET), doxycycline[ ... Tests for antibodies in the blood by ELISA and Western blot is the most widely used method for Lyme diagnosis. A two-tiered ...
PDLIM1 - ويكيبيديا، الموسوعة الحرة
... binds to alpha-actinin-1 and associates with actin filaments and stress fibers in activated platelets and endothelial cells.". ... Blood. 96 (13): 4236-45. PMID 11110697. *Ostendorff HP، Peirano RI، Peters MA، Schlüter A، Bossenz M، Scheffner M، Bach I (2002 ...
Lassa fever
Other laboratory findings in Lassa fever include lymphocytopenia (low white blood cell count), thrombocytopenia (low platelets ... Fluid replacement, blood transfusion, and fighting hypotension are usually required. Intravenous interferon therapy has also ... and elevated aspartate transaminase levels in the blood. Lassa fever virus can also be found in cerebrospinal fluid.[16] ... to avoid contact with blood and body fluids. These issues in many countries are monitored by a department of public health. In ...
Nephrology
Basic blood tests can be used to check the concentration of hemoglobin, platelets, sodium, potassium, chloride, bicarbonate, ... Blood products including intravenous immunoglobulin and a process known as plasma exchange can also be employed. ... An erythropoetin stimulating agent may be required to ensure adequate production of red blood cells, activated vitamin D ... Treatments in nephrology can include medications, blood products, surgical interventions (urology, vascular or surgical ...
Moclobemide
... causes a doubling of the blood plasma levels of moclobemide.[8] Blood plasma levels of trimipramine and maprotiline and ... Platelet MAO is of the MAO-B and this is inhibited only to a small degree in humans; the inhibition is due to low levels of ... No significant rise in blood pressure occurs when moclobemide is combined with amines such as tyramine-containing foods or ... which cause a severe rise in blood pressure with such combination.[9] Due to the lack of anticholinergic, cardiovascular, ...
Knee cartilage replacement therapy
The procedure creates a blood clot scaffold on which injected PBPCs can be recruited and enhance chondrogenesis at the site of ... "Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet ... microfracture surgery followed by postoperative injections of autologous peripheral blood progenitor cells (PBPCs) and ... "Articular cartilage regeneration with autologous peripheral blood progenitor cells and hyaluronic Acid after arthroscopic ...
Ken Strauss
Enumeration of CD4+ T-cells in the peripheral blood of HIV-infected patients: interlaboratory study of the FACSCount system. ... platelet activation in vascular disease and stem cell transplantation in cancer patients. As an endocrinologist he has an ... 1999 October 15;38(5):231-7. V. Chernyshov, E. Vykhovanets, I. Slukvin, Y. Antipkin, A. Vasyuk, K. Strauss, Analysis of blood ... Age-related changes in Human blood lymphocyte subpopulations. Clinical Immunology and Immunopathology, 1994; 70:152-158. K. ...
Fibrinolysis
t-PA is released into the blood very slowly by the damaged endothelium of the blood vessels, such that, after several days ( ... Fibrinolysis is a process that prevents blood clots from growing and becoming problematic.[1] This process has two types: ... This may help to avoid the use of blood products such as fresh frozen plasma with its associated risks of infections or ... in whole blood, even in patients on heparin. In this assay, increased fibrinolysis is assessed by comparing the TEM profile in ...
Index of HIV/AIDS-related articles
wasting syndrome - Western blot - white blood cells - wild-type virus - window period - Women's Interagency HIV Study (WIHS) - ... platelets - PML - Pneumocystis jiroveci pneumonia (formerly Pneumocystis carinii or PCP) - POL - polymerase - Polymerase chain ... blood-brain barrier - body fat redistribution (BFR) syndrome - body fluids - bone marrow - bone marrow suppression - booster - ... complete blood count (CBC) - computed tomography scan (C-T scan) - concomitant drugs - condyloma - condyloma acuminatum - ...
White blood cell
... which distinguishes them from the other blood cells, the anucleated red blood cells (RBCs) and platelets. Types of white blood ... All white blood cells are nucleated, which distinguishes them from the anucleated red blood cells and platelets. Types of ... Histamine is responsible for widening blood vessels and increasing the flow of blood to injured tissue. It also makes blood ... "Blood. 96 (13): 4028-38. PMID 11110670.. *^ a b c d e f Kumar V, et al. (2010). Robbins and Cotran pathologic basis of disease ...
Psoralen
2009). "Universal adoption of pathogen inactivation of platelet components: impact on platelet and red blood cell component use ... in platelet and plasma blood components prepared for transfusion support of patients. Prior to clinical use, amotosalen-treated ... Water solubility is important for two reasons: pharmacokinetics relating to drug solubility in blood and necessitating the use ... An additional use for optimized psoralens is for the inactivation of pathogens in blood products. The synthetic amino-psoralen ...
Antiphospholipid syndrome
APS provokes blood clots (thrombosis) in both arteries and veins as well as pregnancy-related complications such as miscarriage ... A low platelet count and positivity for antibodies against β2-glycoprotein 1 or phosphatidylserine may also be observed in a ... Kay Thackray (2003). Sticky Blood Explained. Braiswick. ISBN 978-1-898030-77-5.. A personal account of dealing with the ... Often, this disease is treated by giving aspirin to inhibit platelet activation, and/or warfarin as an anticoagulant. The goal ...
Brain-derived neurotrophic factor
"Blood chemicals link' to eczema". BBC News. 26 August 2007.. *^ Shu XQ, Mendell LM (July 1999). "Neurotrophins and hyperalgesia ... Platelet-derived growth factor (A, B, C, D). *Kinase inhibitors: Agerafenib. *Axitinib ... "Blood levels of brain-derived neurotrophic factor correlate with several psychopathological symptoms in anorexia nervosa ...
Innate immune system - Simple English Wikipedia, the free encyclopedia
... several knobby white blood cells including lymphocytes, a monocyte, a neutrophil, and many small disc-shaped platelets. ... White blood cells identify and remove foreign substances present in organs, tissues, blood and lymph. ... A scanning electron microscope image of normal circulating human blood. One can see red blood cells, ... All white blood cells (WBC) are known as leukocytes. Leukocytes are different from other cells of the body: they work like ...
Intercellular cleft
Blood plasma without the plasma proteins, red blood cells, and platelets pass through the intercellular cleft and into the ... Continuous blood capillaries have the smallest intercellular clefts, with discontinuous blood capillaries having the largest ... Most notably, intercellular clefts are described in capillary blood vessels. The three types of capillary blood vessels are ... Intercellular clefts also play a role in the formation of the blood-heart barrier (BHB). The intercellular cleft between ...
নিতম্বাস্থি - উইকিপিডিয়া
লোহিত রক্তকণিকা (Red blood cell). *অণুচক্রিকা (Platelet). *রক্তরস (Plasma). লসিকা তন্ত্র ও. অনাক্রম্যতন্ত্র. *লসিকা (Lymph) ...
Interleukin 8
Blood 94 (6): 1878-89. PMID 10477716. Cite uses deprecated parameter ,month=. (help) ... resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily". Hum. Genet. 84 (2): 185- ...
FLNB
Xu W, Xie Z, Chung DW, Davie EW (1998). "A novel human actin-binding protein homologue that binds to platelet glycoprotein ... Ibalpha". Blood. 92 (4): 1268-76. PMID 9694715.. *. Bröcker F, Bardenheuer W, Vieten L, et al. (1999). "Assignment of human ...
Necrotizing enterocolitis
The gut mucosal cells do not get enough nourishment from arterial blood supply to stay healthy, especially in very premature ... Laboratory changes (metabolic acidosis, too few platelets in the bloodstream). *Bell's stage 3 (advanced disease): *Severe ... The underlying mechanism is believed to involve a combination of poor blood flow and infection of the intestines.[2] Diagnosis ... blood in the stool, or vomiting of bile.[1][2] ... infants, where the blood supply is limited due to immature ...
Innate immune system
... several knobby white blood cells including lymphocytes, a monocyte, a neutrophil, and many small disc-shape platelets. ... Identification and removal of foreign substances present in organs, tissues, blood and lymph, by specialized white blood cells ... A scanning electron microscope image of normal circulating human blood. One can see red blood cells, ... All white blood cells (WBCs) are known as leukocytes. Most leukocytes differ from other cells of the body in that they are not ...
Pegaptanib
... the formation of new blood vessels) and increased permeability (leakage from blood vessels), two of the primary pathological ... Platelet-derived growth factor (A, B, C, D). *Kinase inhibitors: Agerafenib. *Axitinib ... This then reduces the growth of the blood vessels located within the eye and works to control the leakage and swelling.[2] ... was also found that subcutaneous and intravenous routes of administration were also effective at maintaining the desired blood ...
Jehovah's Witnesses
... epidural blood patch, plasmapheresis, blood labeling or tagging and platelet gel (autologous) ... Rejection of blood transfusions. Main article: Jehovah's Witnesses and blood transfusions. Jehovah's Witnesses refuse blood ... Though Jehovah's Witnesses do not accept blood transfusions of whole blood, they may accept some blood plasma fractions at ... "The Real Value of Blood". Awake!. August 2006. p. 11.. *^ Durable Power of Attorney form. Watch Tower Society. January 2001. p ...
Faktor XI - Wikipedie
Roles of platelets and factor XI in the initiation of blood coagulation by thrombin. Thromb. Haemost.. July 2001, roč. 86, čís ... Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with ...
Platelet-derived growth factor
In particular, PDGF plays a significant role in blood vessel formation, the growth of blood vessels from already-existing blood ... Though PDGF is synthesized,[3] stored (in the alpha granules of platelets),[4] and released by platelets upon activation, it is ... "The Basic Biology of Platelet Growth Factors". Retrieved 2014-05-08.. *^ Kumar, Vinay (2010). Robbins and Coltran Pathologic ... Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. ...
Bradykinin
It is a peptide that causes blood vessels to dilate (enlarge), and therefore causes blood pressure to fall. A class of drugs ... further lowering blood pressure. Bradykinin dilates blood vessels via the release of prostacyclin, nitric oxide, and ... "Hyperfibrinolysis increases blood-brain barrier permeability by a plasmin- and bradykinin-dependent mechanism". Blood. 128 (20 ... Bradykinin was detected in the blood plasma of animals after the addition of venom extracted from the Bothrops jararaca ( ...
Coagulation factor II receptor
... blood. 105 (8): 3178-84. doi:10.1182/blood-2004-10-3985. PMID 15626732. José RJ, Williams AE, Mercer PF, Sulikowski MG, Brown ... Molino M, Bainton DF, Hoxie JA, Coughlin SR, Brass LF (Feb 1997). "Thrombin receptors on human platelets. Initial localization ... Hoffman M, Church FC (Aug 1993). "Response of blood leukocytes to thrombin receptor peptides". Journal of Leukocyte Biology. 54 ... Blood. 89 (6): 1944-53. PMID 9058715. This article incorporates text from the United States National Library of Medicine, which ...
Wiskott-Aldrich syndrome protein
97 (9): 2633-9. doi:10.1182/blood.v97.9.2633. PMID 11313252.. *^ a b She HY, Rockow S, Tang J, Nishimura R, Skolnik EY, Chen M ... and small-sized platelets) in these patients the protein is usually significantly reduced or absent. Other, less inactivating ... blood coagulation. • positive regulation of Arp2/3 complex-mediated actin nucleation. • actin filament-based movement. • ...
Bacterial Contamination of Platelets | Blood Safety | CDC
Clinicians need to be aware of bacterial contamination of blood products, especially platelets. ... In practice, the type of platelet donation (apheresis or whole blood-derived platelets) has dictated the bacterial detection ... Clinician is contacted by the blood collection or transfusion service with information involving a blood or blood component ... Most blood collection centers culture apheresis platelets (derived from single donors), and release the unit after the culture ...
The Biggest Blood Supply Risk: Tainted Platelets - WSJ
Hospitals and blood banks are adopting new measures to improve the safety of donated platelets-the tiny cells that make blood ... Hospitals and blood banks are adopting new measures to improve the safety of donated platelets-the tiny cells that make blood ... Unlike other blood components such as red cells, which are refrigerated, platelets must be stored at room temperature to remain ... A growing number of studies show that standard tests performed by blood banks before they ship platelets to hospitals miss the ...
low blood platelets | DailyStrength
Ive had low blood platelets for as long as I can remember.Even before I discovered I was Hep C+. I went thru tx( peg-intron- ... The hepatitis C virus (HCV) is spread by blood-to-blood contact with an infected persons blood. Many people with HCV infection ... or back up of blood flow. THE LARGE SPLEEN sequesters or HIDES platelets....hence the low platelets (thrombocytopenia) 3) The ... Ive had low blood platelets for as long as I can remember.Even before I discovered I was Hep C+. I went thru tx( peg-intron- ...
Blood Platelets Can Kill Malaria Parasites | WebWire
New studies in mice suggest that blood platelets can destroy deadly malaria parasites, but a single dose of aspirin may be ... Platelets are well known for their role in blood clotting and blood vessel repair. Previous studies have shown that platelets ... We believe that s because platelets bind to infected red blood cells and are taken out of circulation because of that, Foote ... New studies in mice suggest that blood platelets can destroy deadly malaria parasites, but a single dose of aspirin may be ...
The Cytoskeleton of Human Blood Platelets | SpringerLink
Blood platelets are deceptively simple cells. They circulate in the form of flattened disks, dwarfed by the larger erythrocytes ... The Cytoskeleton of Human Blood Platelets. In: Harris J.R. (eds) Megakaryocytes, Platelets, Macrophages, and Eosinophils. Blood ... White, J. G., and Sauk, J. J., 1984, Microtubule coils in spread blood platelets, Blood 64: 470-478.PubMedGoogle Scholar ... Actin Filament Human Platelet Detergent Extraction Parallel Bundle Human Blood Platelet These keywords were added by machine ...
COVID-19 triggers changes in blood platelets
Changes in blood platelets triggered by COVID-19 could contribute to the onset of heart attacks, strokes, and other serious ... Tags: Aspirin, Blood, Blood Clot, Blood Pressure, Diabetes, Gene, Gene Expression, Genetic, Heart, Hematology, High Blood ... Manne, B.K., et al. (2020) Platelet Gene Expression and Function in COVID-19 Patients. Blood. doi.org/10.1182/blood.2020007214. ... Changes in blood platelets triggered by COVID-19 could contribute to the onset of heart attacks, strokes, and other serious ...
Platelets and Thrombopoiesis | Blood Journal
Blood group alters platelet binding kinetics to von Willebrand factor and consequently platelet function Eimear Dunne, Qin M. ... Blood 2019 :blood-2018-10-881557; doi: https://doi.org/10.1182/blood-2018-10-881557 ... Blood 2019 :blood-2018-11-835371; doi: https://doi.org/10.1182/blood-2018-11-835371 ... Megakaryocytes and platelets from a novel human adipose tissue-derived mesenchymal stem cell line Keiichi Tozawa, Yukako Ono- ...
Low Blood Platelets - Celiac.com
... caused by low blood platelets. Have any of you ever ... ... Low Blood Platelets By kschmitz, January 25, 2005. in Related ... caused by low blood platelets. Have any of you ever had this diagnosis? Low platelets can be the result of an autoimmune ... Just wondering how the platelets and petechaia turned out -- still there? How low are your platelets? ... Blood? Same. Since that period I have ordered re-tests on all three types of tests, this time from different companies, and ...
TOO MANY PLATELETS CAN LEAD TO BLOOD PROBLEMS - Sun Sentinel
What causes the increase? What is the danger of too many platelets? -- P.D. ... and my platelet count was 470,000. Three months ago it was 500,000. A week ago it was 650,000. ... Donohue: I had blood work done six months ago, ... TOO MANY PLATELETS CAN LEAD TO BLOOD PROBLEMS. DR. PAUL DONOHUE ... Polycythemia is the blood illness where bone marrow makes too many red and white blood cells and too many platelets. By now, ...
Red Cross Urges Blood or Platelet Donation
The American Red Cross urges eligible donors to end summer on a positive and potentially lifesaving note with a blood or ... but blood and platelet donors are still needed to help ensure blood products are available to meet hospital patient needs. ... Blood can be safely donated every 56 days and platelets can be given every seven days - up to 24 times a year. To make an ... Red Cross urges eligible donors to close out summer with a blood or platelet donation ...
Platelet antibodies blood test: MedlinePlus Medical Encyclopedia
Platelets are a part of the blood that helps the blood clot. ... shows if you have antibodies against platelets in your blood. ... This blood test shows if you have antibodies against platelets in your blood. Platelets are a part of the blood that helps the ... Abnormal results show that you have anti-platelet antibodies. Anti-platelet antibodies may appear in the blood due to any of ... Platelet and blood vessel disorders. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook ...
RAPid signaling in platelets | Blood Journal
Emerging roles for platelets as immune and inflammatory cells. Blood. 2014;123(18):2759-2767. ... In this issue of Blood, Stefanini et al untangle the specific roles of RAP1A and RAP1B in platelet production, signal ... Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood. 2011;118(14):e101-e111. ... RAPid signaling in platelets. Blood, 132(18), 1864-1865. Accessed November 14, 2018. https://doi.org/10.1182/blood-2018-09- ...
Donate Blood or Platelets
How Do You Build up Blood Platelets? | Reference.com
... a change in diet can help build up blood platelets. An organic diet rich in nutrients can have a beneficial effect on someones ... What Is the Normal Blood Platelet Level?. A: In healthy adults, the normal blood platelet count is 150,000 to 400,000 platelets ... What Are High Blood Platelets a Sign Of?. A: Having too many platelets in the blood is a sign of either thrombocytosis or ... What Is the Easiest Way to Raise Blood Platelets?. A: The easiest way of increasing the level of blood platelets is by eating ...
A Special Valentine to Blood and Platelet Donors
BE A HERO THIS VALENTINES DAY Schedule an appointment to donate blood or platelets using the Red Cross Blood Donor App, ... POWER REDS AND PLATELETS NEEDED Eligible donors with types O, A negative and B negative blood are urged to make a Power Red ... Blood and platelet donors are heroes who answer the call to roll up a sleeve and help ensure an adequate supply is available ... Unlike whole blood, which can be safely donated every 56 days, platelets can be donated every seven days, up to 24 times a year ...
Thrombocytopenia (Low Blood Platelets) in Dogs - PetPlace
Transfusion of whole blood, which contains plasma and all blood cell types including red blood cells and platelets, or packed ... Thrombocytopenia refers to an abnormally low blood-concentration of platelets, which are blood cells that promote blood ... Dogs with blood platelet concentrations of less than 40,000 per microliter of blood are at risk for spontaneous bleeding. ... Low Blood Platelets) in Dogs. Treatment for thrombocytopenia depends on the underlying cause of the low platelet count. ...
Low blood platelet symptoms
Platelets allow blood to clot, so the main symptoms of low blood platelets include bruising, an inability to stop bleeding from ... Low blood platelets can be a dangerous condition. ... Platelets are cells in the blood that help the blood to clot, ... Low blood platelets can be a dangerous condition. Platelets allow blood to clot, so the main symptoms of low blood platelets ... There are several treatments available for people with low blood platelets. If your low blood platelet count is due to ITP, you ...
Mumbai: BMC wants blood banks to supply platelets judiciously | mumbai | Hindustan Times
... the BMC wants blood banks to supply blood and its components such as platelets, plasma, judiciously. ... To avoid adverse effects in patients as a result of excessive and unnecessary blood transfusions, ... The civic body wants blood banks to monitor supply of blood platelets and other components and identify any over-prescription ... the BMC wants blood banks to supply blood and its components such as platelets, plasma, judiciously. mumbai Updated: May 22, ...
Current aspects of blood coagulation, fibrinolysis, and platelets (Book, 1993) [WorldCat.org]
... and platelets. [M -C Shen; C -M Teng; Akikazu Takada;] ... "Blood Platelets"@en ;. schema:name "Blood platelets"@en ;. .. < ... Blood platelets. a schema:Intangible ;. schema:name "Blood platelets"@en ;. .. ... http://experiment.worldcat.org/entity/work/data/369351063#Topic/blood_platelets> # Blood Platelets. a schema:Intangible ;. rdfs ... schema:about blood_platelets> ; # Blood Platelets. schema: ...
Donating platelets with Canadian Blood Services
In a healthy person, a large number of platelets are manufactured and stored in the body. ... Platelets are the component of blood that helps with clotting. ... Platelets are about a quarter of the size of red blood cells ... Platelets are the component of blood that helps with clotting. If an injury or blood loss occurs, platelets are released, and a ... Regular donors can give platelets every two weeks. Ask us about donating platelets at your next whole blood donation or give us ...
Blood platelet - definition of blood platelet by The Free Dictionary
blood platelet synonyms, blood platelet pronunciation, blood platelet translation, English dictionary definition of blood ... n. any of the minute, nonnucleated cellular elements in mammalian blood essential for coagulation. Noun 1. blood platelet - ... blood platelet. Also found in: Thesaurus, Medical, Encyclopedia. blood platelet. n.. See platelet. ... blood platelet - tiny bits of protoplasm found in vertebrate blood; essential for blood clotting. platelet, thrombocyte ...
The blood platelet in transfusion therapy (Book, 1978) [WorldCat.org]
The blood platelet in transfusion therapy. [Tibor J Greenwalt; G A Jamieson; American National Red Cross.;] ... Blood platelets--Transfusion a schema:Intangible ;. schema:name "Blood platelets--Transfusion"@en ;. . ... Blood platelets--Transfusion a schema:Intangible ;. schema:name "Blood platelets--Transfusion"@en ;. . ... The blood platelet in transfusion therapy. Author:. Tibor J Greenwalt; G A Jamieson; American National Red Cross.. ...
Morphodynamics of Blood Platelets
... Platelet plug formation is a major step in physiological hemostasis, but also in ... Approximately 750 billion platelets circulate in human blood, constantly scanning the vasculature for damage of the endothelial ... followed by platelet activation, adhesion and spreading. During this stepwise processes platelets undergo dramatic shape ... Our main goal is to dissect the molecular and mechanical cues regulating platelet cytoskeleton dynamics and platelet motility ...
Hemostasis and Platelet Biology | National Heart, Lung, and Blood Institute (NHLBI)
Platelets | San Diego Blood Bank
Platelets from all donor types are needed.Platelets have a very limited shelf life of five days and are delivered quickly to ... Patients undergoing bone marrow transplants, surgeries, chemotherapy, radiation or organ transplants often need platelets to ... Platelets are blood cells that help control bleeding. ... Platelets are blood cells that help control bleeding. Patients ... Platelet donors are eligible every two weeks. The collection process is longer than whole blood so you should be prepared to ...
Donate Blood and Platelets - Dana-Farber Cancer Institute | Boston, MA
... or give blood on board the Dana-Farber Cancer Institute/Brigham and Womens Hospital Blood Mobile, you are making a life-saving ... When you donate blood or platelets at the Kraft Family Blood Donor Center at Dana-Farber Cancer Institute and Brigham and ... All of the blood and platelets collected at the Kraft Center and on the Blood Mobile benefit patients at Dana-Farber and ... When you donate blood or platelets at the Kraft Family Blood Donor Center at Dana-Farber Cancer Institute and Brigham and ...
True Blood: The Critical Need for Platelets | Citydesk | Boise Weekly
Platelets are really special, because thats what were using for trauma victims, someone who has just got of surgery or cancer ... It turns out the platelet donation process is a bit more time-consuming that the typical blood donation-it can take up to two ... He knows the location well, his donation of a pint of blood platelets brings his total contributions, to date, to nearly 50 ... Donors can specify whether theyre willing to give plasma, red blood cells or platelets. ...
Help People With Cancer: Donate Blood and Platelets | Cancer.Net
Donating blood or platelets is safe and simple, and it can save lives. ... More than 44,000 blood donations are needed every day, according to the American Red Cross. ... How to donate blood or platelets. If youd like to donate blood or platelets, a good first step is to find your local Red Cross ... Why blood and platelet donations are needed. Unlike medicine, blood products cannot be made in a laboratory. But sometimes, ...
HealthBoards - View Single Post - low blood platelet
Optical Sensing Device for Blood Platelets - Tech Briefs
Seattle-based company Blood Cell Storage develop an innovative optical sensing device designed to measure the pH of platelet ... products without compromising blood storage bags. The florescence sensor integrated with a platelet storage bag allows quality ... monitoring without compromising the bag - a first in the blood platelet industry. ... Optical Sensing Device for Blood Platelets. Researchers at Pacific Northwest National Laboratory helped the Seattle-based ...
DonationTransfusionsDonorsTransfusionThrombocytopeniaAmount of plateletsAggregationUnits of plateletsSupply of plateletsClotDisordersDisseminated intravasculAffect platelet functionCountsMegakaryocytesClotsPatientsThrombocytesVesselCenters2018BoneCellsIncrease plateletHuman plateletsBody'sDonations to go uncollectedChemotherapyBecoming a platelet donorBloodstreamAntibodiesCountApheresisGive blood or plateletsDonor CenterProteinsLarge number of plateletsDonate bloodShelf lifeDetected platelet dysfunctionAspirinInflammation2017Immune systemHigh Blood PlateletsPerson'sVarious plateletPlasma and plateletsEnough plateletsCirculate in human bloodGift of plateletsProduction of plateletsLevels of plateletsContamination of plateletsVesselsSingle plateletThrombocytosisDisorderAbnormalExtra plateletsNormal plateletsFunctionBillion plateletsMicroliter of bloodOccursUrgent need
Donation82
- The American Red Cross urges eligible donors to end summer on a positive and potentially lifesaving note with a blood or platelet donation this Labor Day holiday. (redcross.org)
- Since we first began our partnership in 2012, they have gone above and beyond to serve as champions for blood donation - from raising awareness and volunteering, to donating blood and platelets themselves. (redcross.org)
- Those who come to donate through February 26, 2017 are eligible to receive a $5 Amazon.com gift card via email for making blood and platelet donation a priority this winter. (redcross.org)
- POWER REDS AND PLATELETS NEEDED Eligible donors with types O, A negative and B negative blood are urged to make a Power Red donation, where available. (redcross.org)
- Power Red donors give a concentrated dose of red blood cells during a single donation, allowing them to maximize their impact. (redcross.org)
- Platelets must be transfused within five days of donation, so it's important that eligible platelet donors give as often as possible. (redcross.org)
- Once a campaign is created, invite colleagues, friends and family to pledge their support by making an appointment to donate at a blood drive or donation center convenient for them. (redcross.org)
- Those who are not eligible to give blood, do not have a Red Cross blood donation opportunity nearby or simply want to do more can support a SleevesUp campaign by making a financial donation. (redcross.org)
- The platelet donation process follows the same steps as whole blood donation registration, screening, donation and after-care. (blood.ca)
- Ask us about donating platelets at your next whole blood donation or give us a call at 1 888 2 DONATE (1-888-236-6283). (blood.ca)
- How long does a platelet donation take? (blood.ca)
- The plateletpheresis process is usually about 75 to 100 minutes for a large-volume donation and about 50 to 75 minutes for a single-unit donation, depending on your platelet count. (blood.ca)
- Large-volume donations collect two times more platelets than a single donation. (blood.ca)
- One large volume donation makes twice as much transfusable platelet units. (blood.ca)
- Since our bodies manufacture and store extra platelets, the platelets collected during your donation is replaced almost immediately. (blood.ca)
- If you do wish to donate both blood and platelets, you need to wait 56 days after either type of donation before making the other. (blood.ca)
- You're welcome to try different donation programs to see which you like best: blood, plasma or platelets. (blood.ca)
- If you are thinking of making your first platelet donation or want to book an appointment, call your local donor centre. (blood.ca)
- Is it possible to draw only platelets from a donation? (blood.ca)
- As with a whole blood donation, we insert a needle into your arm and draw blood from your body. (blood.ca)
- Dr Shahinaz clarified that blood platelet donation is similar to blood donation but it takes longer time. (thefreedictionary.com)
- You can Make the Most of Your Donation by becoming a platelet donor. (sandiegobloodbank.org)
- When you give platelets, you have the satisfaction of knowing your donation will make a difference in someone's life immediately. (sandiegobloodbank.org)
- But first, he'll be going to the local Red Cross blood donation center. (boiseweekly.com)
- He knows the location well, his donation of a pint of blood platelets brings his total contributions, to date, to nearly 50 gallons. (boiseweekly.com)
- It turns out the platelet donation process is a bit more time-consuming that the typical blood donation-it can take up to two hours-but donations can be made more often (weekly) as opposed to regular blood cells, which can be donated every 42 days. (boiseweekly.com)
- And donors can certainly refer to that when they come in, but most of the time, people just say 'platelet donation. (boiseweekly.com)
- Blood donation drives are slated at locations across the Treasure Valley throughout the summer. (boiseweekly.com)
- Giving a whole-blood donation usually takes about 10 minutes. (cancer.net)
- This process is called apheresis and is slightly different from giving a whole-blood donation. (cancer.net)
- During the platelet donation, blood is removed from one arm, and then a centrifuge separates out the platelets. (cancer.net)
- More platelets are collected this way than with whole-blood donation. (cancer.net)
- Platelet donation takes 2 hours and can have mild side effects like chills or tingling. (cancer.net)
- Talk with your doctor's office or local blood donation center to find out more. (cancer.net)
- Why do blood donation centers bother with platelets? (metafilter.com)
- I gave a 2-hour platelet donation today and the whole process seemed inefficient. (metafilter.com)
- Is it really much more efficient to get platelets this way rather than separating them out of a whole blood donation that takes much less time and potentially less of their employees time? (metafilter.com)
- There are only a small number of platelets in a normal blood donation, they can extract up to 4-8 times the amount of platelets the way they did with you today. (metafilter.com)
- Also patients who need platelets often only need platelets, not a whole blood transfusion (this is common for cancer patients since chemo is so hard on platelets), so you donating just platelets and getting back the rest means they don't have to post-process your donation to remove components. (metafilter.com)
- Yes the donation takes longer, but I've never had to wait in line so clearly most blood centers are able to handle multiple types of traffic without too much trouble. (metafilter.com)
- When I donate, I can usually give a triple, so someone who needs 3 units of platelets can use my whole donation, and have only one chance at that incompatibility. (metafilter.com)
- Gotcha - so they get many more platelets per donation, and individuals who give platelets regularly can give much more often than whole blood, so even if they have fewer donors they're able to get more platelets this way than from whole blood. (metafilter.com)
- TUCSON, AZ (Tucson News Now) - Ongoing severe winter weather has more than doubled the number of canceled American Red Cross blood drives and the resulting blood and platelet donation shortfall since earlier this month. (kold.com)
- Below is a list of upcoming blood donation opportunities in southern Arizona through Thursday, Feb. 15. (kold.com)
- The Red Cross checks your blood pressure before every donation! (redcrossblood.org)
- If you are a platelet donor, you may be told to increase your calcium intake a day or two prior to your donation. (redcrossblood.org)
- One platelet donation can contain enough platelets for three therapeutic doses . (cityofhope.org)
- Are you eligible for blood donation? (redcrossblood.org)
- Learn how blood donations help, what to expect, and how to get ready for your first blood donation. (redcrossblood.org)
- New to blood donation? (redcrossblood.org)
- Enter your information to learn the truth about some blood donation myths and how you can help patients. (redcrossblood.org)
- Jordan was willing to sacrifice the extra time needed to give platelets, but a whole blood donation, when WHNT News 19's Chris Davis went through the process on Wednesday, took just under 30 minutes. (whnt.com)
- Please visit www.mskcc.org/blooddonations for complete information about donor eligibility and the donation process for blood or platelets. (911families.org)
- Below, explore the blood and platelet donation facts and figures to learn how you can give the gift of life to pediatric patients at Children's National. (childrensnational.org)
- While the American Red Cross worked nonstop to support those affected by Hurricane Dorian, the storm forced blood donation centers and blood drives to be closed. (theitem.com)
- Platelets -- a key clotting component of blood often needed by cancer patients, burn victims and bone marrow recipients -- must be transfused within five days of donation. (whig.com)
- In order to donate covalescent plasma you must qualify for blood donation. (uclahealth.org)
- Clark County Blood Donation Center, 1805 E. 8th St.Sellersburg3/16/2015: 3 p.m. - 7 p.m. (wlky.com)
- East End Louisville Blood Donation Center, 291 N. Hubbards Lane3/10/2015: 11 a.m. - 6:30 p.m. (wlky.com)
- Downtown Louisville Blood Donation Center, 520 E. Chestnut St.3/10/2015: 3 p.m. - 7 p.m., St. Edward, 9608 Sue Helen Drive3/10/2015: 4 p.m. - 7 p.m. (wlky.com)
- Downtown Louisville Blood Donation Center, 520 E. Chestnut St.3/12/2015: 12 p.m. - 7 p.m. (wlky.com)
- Downtown Louisville Blood Donation Center, 520 E. Chestnut St.3/14/2015: 8 a.m. - 1 p.m., St. Athanasius, 5915 Outer Loop3/14/2015: 9 a.m. - 1 p.m. (wlky.com)
- East End Louisville Blood Donation Center, 291 N. Hubbards Lane3/14/2015: 10 a.m. - 2 p.m., St. Marks Episcopal Church, 2822 Frankfort Ave.3/15/2015: 8:30 a.m. - 1:30 p.m. (wlky.com)
- We have an urgent need for blood and platelet donations during the holidays, and blood donation is a great way for blood donors to spread Christmas cheer. (giveblood.org)
- This year on Feb. 26, we honor Dr. Reiss and her legacy through the first-ever Texas Bone Marrow, Blood, and Organ Donation Registry Day, established through the work of State Rep. Gene Wu and passed into law last year. (giveblood.org)
- What type of blood donation works for you? (giveblood.org)
- Whole blood, platelets, red blood cells or plasma - you've got options when it comes to saving lives, and each donation has its benefits. (giveblood.org)
- Visit us today to make your next life-saving blood and platelet donation. (uclahealth.org)
- In order for your donation to go to Andrew, you must donate blood in the Blood Donor Room at Memorial Sloane Kettering. (911families.org)
- Mass Appeal) - Blood platelet donors are known as "cancer kickers" because this special type of donation is used to support patients through cancer treatment. (wwlp.com)
- You can give the gift of life this week at the 22News blood drive happening at the American Red Cross Blood Donation Center, 150 Brookdale Drive in Springfield. (wwlp.com)
- Our platelet donation clinics are in Dublin and Cork. (giveblood.ie)
- Yet many people have never heard of platelet donation. (giveblood.ie)
- Find out more about the platelet donation process by watching the video below featuring Kyran O'Brien, one of our platelet donors, and the journey platelets take from the clinic in the National Blood Centre, through the labs to treat a young patient in Temple Street Children's University Hospital. (giveblood.ie)
- Saving lives is now a regular part of Ralph "Rocco" Russo's life, after an incredible 15 years of platelet donation at Dana-Farber Cancer Institute. (wcvb.com)
- Platelets and plasma can be taken from a whole blood donation too. (nzblood.co.nz)
- But one donation of platelets by apheresis provides the same amount of platelets as 8 to 12 whole blood donations combined. (nzblood.co.nz)
- The record cold exposed a key problem underlying our nation's blood donation system. (statnews.com)
- The current blood donation system is vulnerable to disruption. (statnews.com)
- Has anyone who uses AAS ever tried the platelet/whole blood donation where they hook you up to the machine and extract the red blood cells, and return the plasma in your body? (anabolicminds.com)
- We are urging all eligible donors to do their part to support the community blood supply by calling to schedule a donation appointment this week to help overcome the loss of collections due to the inclement weather," Brown added. (salem-news.com)
- Interested donors can schedule an appointment by calling (800) GIVE LIFE, or by going online to Pacific Northwest Regional Blood Services , where they can also find schedule of convenient donation locations. (salem-news.com)
Transfusions37
- Platelet transfusions also may be an option for all of the causes of low platelet count. (ehow.co.uk)
- To avoid adverse effects in patients as a result of excessive and unnecessary blood transfusions, the BMC wants blood banks to supply blood and its components such as platelets, plasma, judiciously. (hindustantimes.com)
- The Brihanmumbai Municipal Corporation (BMC) has called for a meeting next week with blood banks operating in Mumbai to discuss the 'unnecessary platelet transfusions' in patients, especially those suffering from dengue. (hindustantimes.com)
- Platelet transfusions are lifesaving but can be fatal also as it can cause bleeding," said a senior doctor who is a part of the committee. (hindustantimes.com)
- The doctor said that there had been a case where a 60-year-old man admitted at a private hospital with dengue died, after he was given multiple platelet transfusions even when his platelets were a healthy 70,000 units. (hindustantimes.com)
- Transfusion-related acute lung injury is one of the most common complications of blood transfusions. (hindustantimes.com)
- Doctors have to be extremely cautious while perfor ming blood transfusions in pregnant women," said Dr Rekha Daver, head of gynaecology department, JJ Hospital, Byculla. (hindustantimes.com)
- Patients who have low platelets or platelets that don't function properly (e.g. cancer patients undergoing chemotherapy) need platelet transfusions as part of their treatment. (blood.ca)
- Patients who receive multiple platelet transfusions sometimes produce antibodies that fight the donated platelets and prevent them from performing their clotting function. (blood.ca)
- People with cancer do not often need transfusions of this part of blood. (cancer.net)
- When cancer or its treatment causes low RBCs, called anemia , whole blood transfusions are used to replace the RBCs. (cancer.net)
- Whole blood transfusions can be used to replace blood lost during surgeries, too. (cancer.net)
- Ryan Halliday, the godson of retired FDNY Firefighter Tom Carroll of Engine 219, is 22 years old and needs blood and platelet transfusions. (911families.org)
- Our study is the first one to show that platelet transfusions are frequently administered to patients with ITP, HIT and TTP, and that they're associated with higher odds of arterial blood clots and mortality in TTP and HIT. (eurekalert.org)
- When a panel of experts convened by the AABB -- formerly known as the American Association of Blood Banks -- issued guidelines for platelet transfusions in November 2014, it made no recommendation on treatments for ITP, TTP and HIT. (eurekalert.org)
- Our analysis found no significantly increased risks from platelet transfusions in ITP," Goel says. (eurekalert.org)
- In HIT, platelet transfusions increased the risk of bleeding fivefold and the risk of an arterial clot more than threefold. (eurekalert.org)
- The researchers were surprised to find that one in 10 TTP patients and one in 13 HIT patients got platelet transfusions, in spite of some practitioners' concerns about the risks. (eurekalert.org)
- Tobian and colleagues believe that for patients with HIT and TTP, platelet transfusions should be reserved "only for severe, life-threatening bleeding refractory to other therapies or major surgery. (eurekalert.org)
- They need transfusions of healthy platelets to control their bleeding. (dana-farber.org)
- As new treatments develop, more patients are being successfully treated with platelets which mean there is a growing demand for platelet transfusions. (nzblood.co.nz)
- Management of symptoms related to cancer and cancer treatments may require blood transfusions. (blausen.com)
- For patients who need platelet transfusions, platelets must first be extracted from plasma. (blausen.com)
- Blood transfusions can have some bad side affects. (cancer.org)
- In our OOU unfortunately I see a lot of blood transfusion (I say unfortunately because I tend to faint at the sight of blood) every day there are at least 2 or 3 transfusions going on. (cancer.org)
- Steve has had many blood transfusions. (cancer.org)
- Platelet transfusions came into medical use in the 1950s and 1960s. (wikipedia.org)
- International guidelines recommend that platelets transfusions are given to people with reversible bone marrow failure to reduce the risk of spontaneous bleeding when the platelet count is less than 10 x 109/L. If the person is well using a higher platelet count threshold does not reduce the risk of bleeding further. (wikipedia.org)
- A review in people with blood cancers receiving intensive chemotherapy or a stem cell transplant found that overall giving platelet transfusions when the platelet count is less than 10 x 109/L reduced the number of bleeding events and days with significant bleeding. (wikipedia.org)
- Despite prophylactic platelet transfusions, people with blood cancers often bleed, and other risk factors for bleeding such as inflammation and duration of thrombocytopenia should be considered. (wikipedia.org)
- There is little evidence for the use of preventive platelet transfusions in people with chronic bone marrow failure, such as myelodysplasia or aplastic anemia. (wikipedia.org)
- Multiple guidelines recommend prophylactic platelet transfusions are not used routinely in people with chronic bone marrow failure, and instead an individualised approach should be taken. (wikipedia.org)
- Several studies have now assessed the benefit of using preventive platelet transfusions in adults with dengue who have profound thrombocytopenia (platelet count (wikipedia.org)
- Two reviews in people with blood cancers receiving intensive chemotherapy or a stem cell transplant found that overall giving platelet transfusions when the platelet count is less than 10 x 109/L compared to giving platelet transfusions when the platelet count is less than 20 or 30 x 109/L had no effect on the risk of bleeding. (wikipedia.org)
- This review found no difference in the number of people who had clinically significant bleeding between platelet transfusions that contained a small number of platelets (low dose - 1.1 x 1011/m2) and those that contained an intermediate number of platelets (intermediate dose - 2.2 x 1011/m2). (wikipedia.org)
- In people with a low platelet count, prophylactic platelet transfusions do not need to be given prior to procedures that have a low risk of causing bleeding. (wikipedia.org)
- The evidence is very uncertain about the effect of platelet transfusions prior to surgery for people with a low platelet count on the all-cause mortality, the number of participants with bleeding events after surgery, serious surgery-related or transfusion-related adverse events. (wikipedia.org)
Donors44
- Clinicians should collaborate with hospital transfusion services and blood collection center personnel, and, when necessary, notify health departments, to manage suspected infections in blood donors and patients. (cdc.gov)
- In early August, the Red Cross issued an urgent call for blood donors with types O negative, B negative and A negative blood to donate to help avert an emergency situation. (redcross.org)
- Thousands of people have answered the call to donate in recent weeks, but blood and platelet donors are still needed to help ensure blood products are available to meet hospital patient needs. (redcross.org)
- Eligible donors are encouraged to make an appointment to give blood or platelets this Labor Day weekend. (redcross.org)
- Blood donors with all types, especially O negative, B negative and A negative, are urged to give. (redcross.org)
- Platelet donors and those with type AB blood are also continually needed. (redcross.org)
- Blood and platelet donors are heroes who answer the call to roll up a sleeve and help ensure an adequate supply is available for patients in need. (redcross.org)
- Thankfully, blood donors came through for Jacqueline and she had multiple successful surgeries. (redcross.org)
- Jacqueline shared a special drawing, complete with red hearts, to express her ongoing gratitude to blood donors. (redcross.org)
- A single platelet treatment would require six to eight whole blood donors instead of just one plateletpheresis donor. (blood.ca)
- Regular donors can give platelets every two weeks. (blood.ca)
- New platelet donors are encouraged to donate once a month. (blood.ca)
- Summary: Dubai hopes to keep special blood platelet supply running smoothly even after encouraging paid donors to become unpaid volunteers by 2020, said a senior health official. (thefreedictionary.com)
- Platelet donors are eligible every two weeks. (sandiegobloodbank.org)
- New England Patriots alum Joe Andruzzi visited the Kraft Family Blood Donor Center at Dana-Farber Cancer Institute and Brigham and Women's Hospital to greet blood and platelet donors, as well as pediatric patients at Dana-Farber/Boston Children's Cancer and Blood Disorders Center. (dana-farber.org)
- Donors can specify whether they're willing to give plasma, red blood cells or platelets. (boiseweekly.com)
- Replenishing blood lost from an injury or chemotherapy requires blood from healthy donors. (cancer.net)
- I'm not talking about inefficiency for for the donor, though it strikes me that they probably have fewer regular donors for platelets since it takes quite a while. (metafilter.com)
- Where as they'd have to get 16 individual donors in who would have to wait 56 days between donations to get the same number of platelets from whole blood. (metafilter.com)
- If that same quantity of platelets came from whole blood, it could have been the product of 20+ donors, so the chance of incompatibility is that much greater. (metafilter.com)
- Additionally, as wwax notes, even though they may have a smaller pool of donors, those donors can donate more frequently (7 days between donations/24 donations per year is the Red Cross limit), so the total amount collected can be much higher than from whole blood. (metafilter.com)
- The American Red Cross considers the situation critical and has reissued an urgent call for blood and platelet donors. (kold.com)
- The American Red Cross has a critical shortage of type O blood and urges type O donors to give now to ensure blood is available for patients facing trauma and other life-threatening situations. (redcrossblood.org)
- We're now calling out for more donors to help us meet that extra need that we're helping to fulfill along with the other community blood centers across the country," says Franchois. (whnt.com)
- An adult dose of platelets derived from whole blood is obtained from a pool of buffy coats from four ABO identical donors and is resuspended in a nutrient additive solution to produce a pooled platelet component. (transfusion.com.au)
- Being able to count on volunteer blood donors at all times is especially important because blood has a limited shelf life. (dana-farber.org)
- Volunteer donors ensure that there will be a sufficient supply of blood for the patients who need it, whenever they need it. (dana-farber.org)
- Volunteer donors are the only source of platelets for these patients. (dana-farber.org)
- Being able to count on volunteer platelet donors at all times is especially important because platelets have a shelf life of just five days. (dana-farber.org)
- Volunteer donors ensure that there will always be a sufficient supply of platelets for patients in need. (dana-farber.org)
- Right now, we're encouraging eligible donors to come out and give to prevent a shortage," said Red Cross spokesman Ben Corey of the Peoria-based Red Cross Heart of Blood Services America region, which oversees West-Central Illinois and Northeast Missouri. (whig.com)
- Hospital patients continue to need lifesaving blood this summer, and they're relying on the generosity of volunteer donors to give them hope in the days and weeks ahead," Heiden said. (whig.com)
- After round after round of snow, freezing rain and arctic cold in many parts of the country, the American Red Cross has an urgent need for eligible blood and platelet donors to donate to help restock its supplies.March storms forced the cancellation of more than 200 blood drives, resulting in nearly 7,000 uncollected blood and platelet donations. (wlky.com)
- The Red Cross is asking donors of all blood types to make and keep appointments to help restock its supplies. (wlky.com)
- Platelet donors, as well as blood donors with the most in-demand blood types - O negative, A negative and B negative - are particularly encouraged to help replenish the blood supply.Platelets help prevent massive blood loss and are a vital part of cancer and organ transplant treatments. (wlky.com)
- Eligible donors with types O negative, A negative and B negative blood are encouraged to donate double red cells where available. (wlky.com)
- We encourage many of our donors to give platelets through an automated system. (giveblood.org)
- Cole was one of several organ, stem cell and blood donors and recipients honored in the 2019 Lone Star Circle of Life Bike Tour. (giveblood.org)
- Platelet donors make an immediate impact. (sandiegobloodbank.org)
- The goal of the UCLA Blood & Platelet Center is to provide patients with safe blood collected from volunteer donors. (uclahealth.org)
- Due to the rising number of cancer diagnosis in the country, there is always a need for platelet donors. (giveblood.ie)
- There are just 2,400 Irish platelet donors and we are looking for new donors to join the panel. (giveblood.ie)
- It relies exclusively on volunteer donors to provide blood for transfusion. (statnews.com)
- In addition to icy, cold weather that has kept many donors from their appointments, colds and flu, and busy schedules after the return from the holidays are also driving down the blood collection rates. (salem-news.com)
Transfusion33
- The actual risk of transfusion-associated sepsis is likely higher, as infections due to contaminated blood products are under-reported. (cdc.gov)
- It is critical that clinicians be aware of the problem of bacterial contamination of blood products, particularly platelets, and consider the possibility of bacterial contamination when investigating febrile transfusion reactions. (cdc.gov)
- If bacterial contamination of a component is suspected, the transfusion should be stopped immediately, the unit saved for further testing, and blood cultures should be obtained from the patient. (cdc.gov)
- Clinician is contacted by the blood collection or transfusion service with information involving a blood or blood component with bacterial contamination. (cdc.gov)
- A blood or blood component recipient has signs or symptoms consistent with post-transfusion bacteremia. (cdc.gov)
- It is difficult to increase platelet numbers adequately by transfusion, and transfused platelets do not last very long - a few days at most. (petplace.com)
- Transfusion of whole blood, which contains plasma and all blood cell types including red blood cells and platelets, or packed red cells, which contains red blood cells without plasma, may be necessary in the event of life-threatening hemorrhage or if your dog is anemic from previous blood loss. (petplace.com)
- Low platelets due to chronic liver disease is generally treated by a platelet transfusion. (ehow.co.uk)
- The blood was then used in a December 2007 transfusion. (huffingtonpost.com)
- Purely hypothetically, it's conceivable that a transfusion of platelets could be administered to restore balance and calm everything down if there are signs of a growth of pathological blood vessels if the child is found to have low levels of platelets,' Ann Hellstrom says. (news-medical.net)
- This time of year brings holiday cheer to many people across the nation, but for hospitals and blood donor centers, such as City of Hope's Michael Amini Transfusion Medicine Center , it's the start of a tough season. (cityofhope.org)
- In cases of uncontrolled bleeding, death can happen in minutes or hours if victims are not treated quickly with a transfusion to replace platelets and other blood cells. (cleveland.com)
- Blood platelets ready for transfusion during surgery. (sciencephoto.com)
- The study authors recommend that for these rare disorders, doctors should administer the treatment, a platelet transfusion, only in exceptional circumstances. (eurekalert.org)
- But in TTP, a platelet transfusion increased the odds of a potentially lethal arterial blood clot more than fivefold and doubled the odds of a heart attack. (eurekalert.org)
- In TTP, the odds of dying in the hospital doubled when the patient was given a platelet transfusion. (eurekalert.org)
- In HIT, the odds of dying were five times greater with a platelet transfusion. (eurekalert.org)
- In some cases, Tobian says, doctors may not know the patient has a platelet disorder until they see the potentially deadly reaction to the transfusion. (eurekalert.org)
- Nationwide, the Red Cross needs to accumulate 15,000 blood donations every day to meet the needs of patients at about 2,700 hospitals and transfusion centers across the country. (whig.com)
- The Irish Blood Transfusion Service provides life-saving platelets to all of the hospitals in Ireland. (giveblood.ie)
- A platelet transfusion can be the difference between life and death for leukaemia patients and people undergoing chemotherapy. (nzblood.co.nz)
- A transfusion is the administration of blood or blood components through a catheter, a tube that enters the body through an intravenous (IV) needle, central venous catheter (CVC), or peripherally-inserted central catheter (PICC). (blausen.com)
- A transfusion can include all or any one of the blood components, and may come from a donor or may have been harvested from the patient prior to therapy. (blausen.com)
- Before a transfusion can be given, results of blood studies must first be analyzed to help determine which blood component the patient will need. (blausen.com)
- has anyone here had a blood transfusion? (cancer.org)
- not sure why blood transfusion is needed. (cancer.org)
- If you are on hormonal, biological (like Avastin or Erbitux) or radiotherapy you cannot get the proscrit shot and require a blood transfusion. (cancer.org)
- i didn't have any problems with the platelet transfusion and I know just one,a that was next to me getting a transfusion told the nurse that about half way through he was starting to feel much better and felt more energy(he had severe anemia). (cancer.org)
- Platelet transfusion, also known as platelet concentrate, is used to prevent or treat bleeding in people with either a low platelet count or poor platelet function. (wikipedia.org)
- Preventive transfusion is often done in those with platelet levels of less than 10 x 109/L. In those who are bleeding transfusion is usually carried out at less than 50 x 109/L. Blood group matching (ABO, RhD) is typically recommended before platelets are given. (wikipedia.org)
- Higher platelet transfusion thresholds have been used in premature neonates, but this has been based on limited evidence. (wikipedia.org)
- A review in people with blood cancers compared different platelet transfusion doses. (wikipedia.org)
- This study's authors suggested that a high-dose platelet transfusion strategy may lead to a higher rate of transfusion-related adverse events. (wikipedia.org)
Thrombocytopenia13
- Thrombocytopenia caused by platelet destruction, hypersplenism, or hemodilution. (medlineplus.gov)
- Thrombocytopenia refers to an abnormally low blood-concentration of platelets, which are blood cells that promote blood clotting after injury to the lining of the blood vessels. (petplace.com)
- The severity of bleeding associated with thrombocytopenia depends on how low the platelet numbers fall. (petplace.com)
- Treatment for thrombocytopenia depends on the underlying cause of the low platelet count. (petplace.com)
- People who have a low blood platelet count, or thrombocytopenia, cannot create platelets as most of our bodies do. (ehow.co.uk)
- Biopharmaceutical company Ligand Pharmaceuticals Incorporated's ( NasdaqGM:LGND) partner GlaxoSmithKline (NYSE:GSK) on Monday jointly announced the receipt of approval for PROMACTA for the treatment of thrombocytopenia (low blood platelet counts) in patients with chronic hepatitis C to allow them to initiate and maintain interferon-based therapy. (thefreedictionary.com)
- People with cancer may develop low platelets, or thrombocytopenia , when the body's bone marrow is damaged from some kinds of chemotherapy or from some types of leukemia or lymphoma. (cancer.net)
- An abnormally small number of platelets, or thrombocytopenia, result from conditions that either impairs production, increase destruction, or cause sequestration of platelets. (scribd.com)
- The regulatory body said: "One plausible explanation for the combination of blood clots and low blood platelets is an immune response, leading to a condition similar to one seen sometimes in patients treated with heparin called heparin induced thrombocytopenia, HIT. (express.co.uk)
- The Johns Hopkins-led study, published Jan. 14, 2015 in Blood , the journal of the American Society of Hematology, is the first nationwide review of nearly 100,000 combined hospital admissions for three rare blood cell disorders: thrombotic thrombocytopenic purpura (TTP), heparin-induced thrombocytopenia (HIT) and immune thrombocytopenic purpura (ITP). (eurekalert.org)
- See also Overview of Platelet Disorders and Overview of Thrombocytopenia . (merckmanuals.com)
- Doctors first do a complete blood count (CBC) to measure the number of platelets and see whether the person's symptoms are caused by a low number of platelets ( thrombocytopenia ). (merckmanuals.com)
- Platelet aggregation response in immune thrombocytopenia patients treated with romiplostim. (harvard.edu)
Amount of platelets3
- As a consequence of that mutation, the mouse produced just one-tenth the normal amount of platelets. (webwire.com)
- In one case cited by the FDA, CBCF staff did not have a sufficient amount of platelets in a bag and filled the remainder with platelets that had been sitting in a biohazardous waste bin for more than 21 hours -- and had not been stored at proper temperature. (huffingtonpost.com)
- Only a small amount of platelets make up plasma. (blausen.com)
Aggregation10
- In laboratory studies, they studied platelet aggregation, an important component of blood clot formation, and observed COVID-19 platelets aggregated more readily. (news-medical.net)
- In this traditional role, platelets patrol the cardiovascular system as specialized cells that rapidly mount a response to stop bleeding via aggregation at the site of vascular damage. (bloodjournal.org)
- These pathways converge at the guanine exchange factor CALDAG-GEFI to activate the GTPase RAP1 (see figure panel A). 4 RAP1 activation leads to rapid platelet adhesion and aggregation mediated by integrins. (bloodjournal.org)
- Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo. (uni-muenchen.de)
- According to Becker, three of the seven genes had been previously reported as having some role in platelet aggregation, but "it was not until now that we put together all the major pieces of the genetic puzzle that will help us understand why some people's blood is more or less prone to clot than others and how this translates into promoting healing and stalling disease progression. (scienceblog.com)
- We employed whole blood platelet aggregation analysis based on impedance as well as determination of ATP release from platelet granules detected by a chemiluminescence method. (hindawi.com)
- Platelet aggregation to low-dose ristocetin revealed an exaggerated response (20.9 ± 18.7 ohms, reference range: 0-5 ohms). (hindawi.com)
- however, unpolymerized methacrylate liposomes markedly inhibited ADP induced platelet aggregation. (dtic.mil)
- Platelet-activating factor, also known as PAF, PAF-acether or AGEPC (acetyl-glyceryl-ether-phosphorylcholine), is a potent phospholipid activator and mediator of many leukocyte functions, platelet aggregation and degranulation, inflammation, and anaphylaxis. (wikipedia.org)
- These developments led to the finding that macrophages produce PAF and that macrophages play an important function in aggregation of platelets and liberation of their inflammatory and vasoactive substances. (wikipedia.org)
Units of platelets4
- We found that the doctors were transfusing 20 to 30 units of platelets in a single patient. (hindustantimes.com)
- It hopes to get 800 units of blood and 560 units of platelets (that's equal to 400 people donating blood and approximately 190 people donating platelets). (cityofhope.org)
- Trauma victims, anyone undergoing surgery, women giving birth, and others can require units of platelets to live. (statnews.com)
- But with 7,000 units of platelets needed every day, the supply can't keep up with demand. (statnews.com)
Supply of platelets3
- Most hospitals have a limited supply of platelets due to their short shelf life. (cleveland.com)
- It's important to have a steady supply of platelets on hand," Corey said. (whig.com)
- We aren't alone in trying to improve the supply of platelets. (statnews.com)
Clot27
- Hospitals and blood banks are adopting new measures to improve the safety of donated platelets-the tiny cells that make blood clot and heal injuries but that also present the No. 1 infection risk in the U.S. blood supply. (wsj.com)
- But with platelets, I believe, the worry is more about bleeding and how fast your blood will clot. (dailystrength.org)
- If we can figure out how COVID-19 is interacting with megakaryocytes or platelets, then we might be able to block that interaction and reduce someone's risk of developing a blood clot. (news-medical.net)
- Platelets are a part of the blood that helps the blood clot. (medlineplus.gov)
- Platelets allow blood to clot, so the main symptoms of low blood platelets include bruising, an inability to stop bleeding from a wound, nosebleeds and skin conditions called purpura and petechiae. (ehow.co.uk)
- Platelets are cells in the blood that help the blood to clot, thereby healing wounds and preventing the loss of too much blood. (ehow.co.uk)
- If an injury or blood loss occurs, platelets are released, and a person's blood begins to clot to prevent excessive bleeding. (blood.ca)
- There's little that first responders can do to help broken blood vessels clot. (cleveland.com)
- What if EMS workers carried synthetic platelets -- the blood's clotting agent - that they could inject to help the victims' blood clot, increasing the likelihood of them reaching a hospital alive? (cleveland.com)
- The peptide coating allows the nanoparticles to stick to a wound and recruit nearby platelets - both natural and artificial - to help form a clot, Pawlowski explained. (cleveland.com)
- Covid vaccine: EMA shares 'plausible explanation' for blood clot links - are you at risk? (express.co.uk)
- The European health body also proposed a "plausible" explanation for the blood clot link. (express.co.uk)
- Johnson & Johnson is the latest pharmaceutical giant to find itself at the centre of the blood clot controversy, after reports that linked its vaccine to blood clots prompted the EMA to release a statement yesterday. (express.co.uk)
- What does it feel like when you have a blood clot? (express.co.uk)
- The finding is curious because platelets (thrombocytes) are colourless blood cells that help blood clot. (express.co.uk)
- They allow blood to clot, helping wounds to heal. (dana-farber.org)
- Cancer patients, people who have sustained trauma, babies in the neonatal intensive care unit, and many other critically ill patients are at serious risk because their blood does not clot properly. (dana-farber.org)
- Considering taking medication to treat blood clot prevention with heparin-induced decreased platelet count? (webmd.com)
- Below is a list of common medications used to treat or reduce the symptoms of blood clot prevention with heparin-induced decreased platelet count. (webmd.com)
- Platelets are cells that are made in the bone marrow and circulate in the bloodstream and help blood clot . (merckmanuals.com)
- These tests measure how long it takes blood to clot. (merckmanuals.com)
- However, the fact that platelets play such a central role in blood clotting does mean that there is a higher risk of clot formation in thrombocytosis. (healthhype.com)
- With the activation of various tissue factors and the laying down of the tougher fibrin strands along with more platelets and blood cells, a blood clot is formed. (healthhype.com)
- These drugs inhibit the normal function of platelets to reduce the chance of clot formation. (healthhype.com)
- He's saved upwards of 600 lives, literally everytime he gives," said Dr. John Luckey, medical director of the Kraft Family Donor Center at Dana-Farber.Platelets help blood clot and are often wiped out during chemotherapy. (wcvb.com)
- Platelets help blood clot and are often wiped out during chemotherapy. (wcvb.com)
- Platelets perform a crucial function in blood, including helping blood to clot, which helps us heal wounds. (wn.com)
Disorders17
- Platelet and blood vessel disorders. (medlineplus.gov)
- RMS due to blood protein or platelet defects may come about through either of two mechanisms: (1) disorders associated with a hemorrhagic tendency or (2) defects associated with a thrombotic tendency. (medscape.com)
- Heparin is a blood thinner given to people with clotting disorders. (express.co.uk)
- People hospitalized with certain rare blood cell disorders frequently receive a treatment that is associated with a two- to fivefold increase in death, according to a new study that reviewed hospital records nationwide. (eurekalert.org)
- All three conditions are immune system disorders marked by low levels of the colorless blood cells called platelets that help seal up damaged blood vessels. (eurekalert.org)
- Follow the links below to find trusted information about blood platelet disorders. (healthdirect.gov.au)
- There are a number of other rare inherited disorders that affect platelets, including Glanzmann disease, Wiskott-Aldrich syndrome , Chédiak-Higashi syndrome, and Bernard-Soulier syndrome. (merckmanuals.com)
- People with inherited disorders of platelet dysfunction may have a lifelong history of easy bruising or excessive bleeding after minor injuries or minor surgery such as dental extractions. (merckmanuals.com)
- Other symptoms of platelet disorders include tiny red dots (petechiae) on the skin and bruising after minor injuries. (merckmanuals.com)
- Doctors suspect an inherited cause if symptoms begin early in life in people who do not have any other disorders or do not take any drugs that cause platelet dysfunction. (merckmanuals.com)
- Blood Platelet Disorders" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- Disorders caused by abnormalities in platelet count or function. (harvard.edu)
- This graph shows the total number of publications written about "Blood Platelet Disorders" by people in Harvard Catalyst Profiles by year, and whether "Blood Platelet Disorders" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Blood Platelet Disorders" by people in Profiles. (harvard.edu)
- López JA, Berliner N. Introduction to a series of reviews on clinical platelet disorders. (harvard.edu)
- Mumford AD, Frelinger AL, Gachet C, Gresele P, Noris P, Harrison P, Mezzano D. A review of platelet secretion assays for the diagnosis of inherited platelet secretion disorders. (harvard.edu)
- One due to bone marrow disorders that results in an overproduction of many blood components, including platelets. (healthhype.com)
Disseminated intravascul1
- Body-wide abnormalities in coagulation (disseminated intravascular coagulation) can result in massive consumption of platelets. (petplace.com)
Affect platelet function4
- Dietary supplements (Vitamin e and fish oil) known to affect platelet function will be assessed and patients on those will be asked to discontinue these. (utsouthwestern.edu)
- Participants with also be asked to not eat foods known to affect platelet function (coffee, chocolate, grapes, and alcohol) 48 hours prior to sample collection on visit 1. (utsouthwestern.edu)
- The most common drugs that affect platelet function are aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs), along with antiplatelet drugs such as clopidogrel and similar drugs that are used to prevent strokes and heart attacks. (merckmanuals.com)
- Diseases that can affect platelet function include cirrhosis , multiple myeloma , kidney disease , and systemic lupus erythematosus (lupus). (merckmanuals.com)
Counts16
- Yes, tx does effect all my blood counts. (dailystrength.org)
- Only five percent of females and 20 percent of males with normal platelet counts died. (webwire.com)
- For example, low platelet counts are often seen in malaria patients in the early stages of infection. (webwire.com)
- Rap1a-mKO and Rap1b-mKO had normal platelet counts. (bloodjournal.org)
- ITP, or immune thrombocytopenic purpura, is the leading cause of low blood platelet counts. (ehow.co.uk)
- The treatment for hepatitis C often causes low blood platelet counts, as does chemotherapy. (ehow.co.uk)
- The patients have been diagnosed with persistent or chronic ITP, and have blood platelet counts consistently below 30,000/uL of blood. (thefreedictionary.com)
- For 75% of patients with normal blood platelet counts, time off chemotherapy was associated with improved quality of life. (thefreedictionary.com)
- 1. A new fixing solution is described, which preserves the platelets and prevents contact hemolysis of the erythrocytes, so that counts of both corpuscles may be made in the same preparation. (rupress.org)
- 2. Comparative counts of platelets in arteries and veins show that arterial blood contains a larger number of platelets than venous blood. (rupress.org)
- As a result my platelet counts are always high (currently 571. (healthboards.com)
- In a group of mice that received heart transplants, those with low platelet counts had heightened immune responses to the transplant, producing an unusually high number of immune cells called T helper 17 cells or Th17 cells. (rochester.edu)
- They may also be needed by patients undergoing major surgery, burns patients, accident victims who have had extensive injury and new born babies who are born with low platelet counts. (giveblood.ie)
- Low platelet counts develop when platelet-producing bone marrow cells are damaged by chemotherapy or radiation therapy. (blausen.com)
- Certain cancers, such as leukemia, can also cause low platelet counts. (blausen.com)
- ENGLAND: Blood platelet counts at the higher end of normal suggest a high risk of cancer in men aged 60 or over, and should be investigated, according to new University of Exeter research. (wn.com)
Megakaryocytes6
- Using newly developed Romanowsky polychrome stains, he was able to follow the origin of platelets from fragmentation of megakaryocytes (Wright, 1910). (springer.com)
- In theory, inflammation caused by COVID-19 could affect megakaryocytes, the cells that produce platelets. (news-medical.net)
- As a result, critical genetic alterations are passed down from megakaryocytes to the platelets, which, in turn, make them hyperactive. (news-medical.net)
- In contrast, Rap1a/b-mKO mice had macrothrombocytopenia due to reduced proplatelet formation demonstrating that RAP1A and RAP1B have overlapping roles in megakaryocytes (see figure panel B). More importantly, this unexpected contribution of RAP1 signaling in megakaryocytes during platelet production opens several lines of investigation for future studies. (bloodjournal.org)
- Budding of the megakaryocytes forms cell fragments known as platelets. (healthhype.com)
- Platelets are made by large cells called megakaryocytes that live in bone marrow. (statnews.com)
Clots14
- The researchers found that inflammatory proteins produced during infection significantly alter the function of platelets, making them 'hyperactive' and more prone to form dangerous and potentially deadly blood clots. (news-medical.net)
- We found that inflammation and systemic changes, due to the infection, are influencing how platelets function, leading them to aggregate faster, which could explain why we are seeing increased numbers of blood clots in COVID patients. (news-medical.net)
- Dear P.D.: Platelets are the blood cells that form clots. (sun-sentinel.com)
- Patients with thrombocytosis often develop clots in healthy blood vessels, and the clots block blood flow. (sun-sentinel.com)
- Our results give us a clear set of new molecular targets, the proteins produced from these genes, to develop tests that could help us identify people more at risk for blood clots and for whom certain blood-thinning drugs may work best or not," says co-senior study investigator and cardiologist Lewis Becker, M.D. (scienceblog.com)
- Anticoagulants or "blood thinners" are used to treat or prevent blood clots in the legs, lungs, or other parts of the body, and to prevent strokes. (mskcc.org)
- THE EUROPEAN Medical Agency (EMA) recommended that blood clots should be listed as a "very rare" side effect of the Johnson & Johnson vaccine in a statement on Tuesday. (express.co.uk)
- The European health body also put forward a "plausible explanation" for the cause of the blood clots. (express.co.uk)
- Therefore a low platelet count should in theory cause prolonged bleeding not blood clots. (express.co.uk)
- TTP is a life-threatening condition in which clots form in small blood vessels, resulting in a low overall platelet count. (eurekalert.org)
- HIT is a life-threatening reaction to the drug heparin, given to patients to prevent the formation of blood clots. (eurekalert.org)
- Platelets (green), the smallest blood cells, clump together into clots to stanch bleeding after an injury. (nih.gov)
- Platelets are known for their role in forming blood clots, but more and more research shows that platelets help control our immune system as well. (rochester.edu)
- and platelets, also called thrombocytes, which assist in the formation of blood clots. (blausen.com)
Patients43
- Changes in blood platelets triggered by COVID-19 could contribute to the onset of heart attacks, strokes, and other serious complications in some patients who have the disease, according to University of Utah Health scientists. (news-medical.net)
- Emerging evidence suggests COVID-19 is associated with an increased risk of blood clotting, which can lead to cardiovascular problems and organ failure in some patients, particularly among those with underlying medical problems such as diabetes, obesity, or high blood pressure. (news-medical.net)
- They compared blood from these patients with samples taken from healthy individuals who were matched for age and sex. (news-medical.net)
- In test tube studies, the researchers found that pre-treating platelets from SARS-CoV-2 infected patients with aspirin did prevent this hyperactivity. (news-medical.net)
- 2020) Platelet Gene Expression and Function in COVID-19 Patients. (news-medical.net)
- The Red Cross must collect 15,000 blood donations every day to meet the needs of patients. (redcross.org)
- All blood types are needed to ensure a reliable supply for patients. (redcross.org)
- Her parents are also supportive of the Red Cross and host Red Cross blood drives in their daughter's honor to help meet the needs of other patients. (redcross.org)
- Community Blood Centers of Florida collects more than 250,000 pints of blood and blood products for hospital and kidney dialysis patients, according to its website. (huffingtonpost.com)
- Vast majority of dengue fever patients recover on their own with due care towards been kept properly hydrated, however, those, developing complications as severe decline in blood platelet are needed to be kept in strict vigilance of doctors and administered with needed blood units, elaborated the program manger of Sindh. (thefreedictionary.com)
- Mayo Clinic recommends patients consult a medical professional to discuss complete blood count results that fall outside the normal ranges. (reference.com)
- Patients undergoing bone marrow transplants, surgeries, chemotherapy, radiation or organ transplants often need platelets to survive. (sandiegobloodbank.org)
- Platelets have a very limited shelf life of five days and are delivered quickly to patients that need them. (sandiegobloodbank.org)
- Patients at Dana-Farber and Brigham and Women's Hospital remain in need of blood products during the COVID-19 outbreak. (dana-farber.org)
- When you donate blood or platelets at the Kraft Family Blood Donor Center at Dana-Farber Cancer Institute and Brigham and Women's Hospital, or give blood on board the Dana-Farber Cancer Institute/Brigham and Women's Hospital Blood Mobile, you are making a life-saving difference for patients in need - right here in our community. (dana-farber.org)
- All of the blood and platelets collected at the Kraft Center and on the Blood Mobile benefit patients at Dana-Farber and Brigham and Women's Hospital. (dana-farber.org)
- And platelets are really special, because that's what we're using for trauma victims, someone who has just got of surgery or cancer patients," said Red Cross Communications Manager Tammy Nakamura. (boiseweekly.com)
- Our results suggest that platelet activation, epinephrine, and high blood pressure play a role in the high prevalence of cerebrovascular and cardiovascular events in patients with OSAS. (nih.gov)
- Platelet function analysis utilizing platelet-rich plasma and optical density based aggregometry fails to identify patients at risk for uremia associated complications. (hindawi.com)
- Ten chronic kidney disease (CKD) stage 4 or 5 predialysis patients underwent platelet evaluation. (hindawi.com)
- Diminished ATP release to arachidonic acid (an aspirin-like defect) in uremic patients may result in platelet associated bleeding. (hindawi.com)
- This platelet hyperreactivity may be associated with a thrombotic diathesis as seen in some uremic patients. (hindawi.com)
- Patients at City of Hope rely on more than 37,000 units of blood and platelets each year for their survival. (cityofhope.org)
- To treat those patients, more than 41,000 blood donations are needed every day. (cityofhope.org)
- Platelets, the clotting components found in blood, are crucial to cancer patients being treated with a bone marrow transplant. (cityofhope.org)
- Each week, the Edward J. Miller, Sr. Blood Donor Center at Children's National needs 100 whole blood donations and 35 platelet donations to provide our pediatric patients with life-saving surgeries and to nurse children back to health from cancer or sickle cell disease. (childrensnational.org)
- The Red Cross urges those who are eligible to help give blood or platelets to ensure patients around the country have access to lifesaving blood. (theitem.com)
- Using the intracellularly trapped fluorescent dye quin2 , the free calcium concentration in platelets was found to be elevated in patients with borderline (n = 8, p less than 0.01) and established essential hypertension (n = 23, p less than 0.001) when compared with normotensive subjects (n = 30). (nih.gov)
- after meeting all inclusion and exclusion criteria during the screening visit, those patients on aspirin for primary prevention of CV events will be asked to stop it for 2 weeks prior to blood collection for baseline data. (utsouthwestern.edu)
- Platelets benefiting patients at both Dana-Farber and Brigham and Women's are collected at the Kraft Family Blood Donor Center , located on the first floor of the Jimmy Fund Building at 35 Binney Street in Boston. (dana-farber.org)
- Each day donations come up short, less blood is available for patients in need. (whig.com)
- Measure thrombocytopathy in a cohort of 70 Gaucher patients using a set of platelet function tests. (clinicaltrials.gov)
- Chisholm KM, Denton C, Keel S, Geddis AE, Xu M, Appel BE, Cantor AB, Fleming MD, Shimamura A. Bone Marrow Morphology Associated With Germline RUNX1 Mutations in Patients With Familial Platelet Disorder With Associated Myeloid Malignancy. (harvard.edu)
- Morrell, an associate professor at the University's Aab Cardiovascular Research Institute , says the idea that platelets keep immune cells in check is a new concept and his team is considering what it means for patients. (rochester.edu)
- Platelets are used in the treatment of cancer and leukemic patients, bone marrow transplant, new born babies and burns victims. (giveblood.ie)
- Platelets are needed every day for the treatment of sick patients. (giveblood.ie)
- So one of the ways we can keep our patients alive during the worst of the chemotherapy is we can replace those platelets with normal healthy donor blood. (wcvb.com)
- Around 28% of all blood donations are used by cancer patients. (nzblood.co.nz)
- Patients receiving chemotherapy often develop low levels of red blood cells, a condition called chemotherapy-induced anemia. (blausen.com)
- Patients with this condition will receive donor red blood cells that have been separated from the blood. (blausen.com)
- For patients who have bleeding problems, studies may show a low platelet count. (blausen.com)
- If you are safely able to leave your house, please consider giving blood for hospital patients," tweeted the Red Cross of Massachusetts . (statnews.com)
- Platelet adhesiveness decreased markedly in six patients within ten minutes after intravenous injection. (ahajournals.org)
Thrombocytes3
- Platelets have another name, thrombocytes. (sun-sentinel.com)
- Premature babies with low levels of platelets (thrombocytes) in their blood run a greatly increased risk of being afflicted with a severe variation of retinopathy of prematurity (ROP), an eye disease that can cause blindness, according to a study from Sweden and US published in the journal JCI Insight . (news-medical.net)
- Platelets (thrombocytes) are blood cell fragments and are essential for blood clotting. (sciencephoto.com)
Vessel11
- Platelets are well known for their role in blood clotting and blood vessel repair. (webwire.com)
- If a blood vessel breaks, platelets cling to each other, forming a cork to plug the leak. (sun-sentinel.com)
- When a blood vessel is damaged, platelets stick to the edges of it, clustering together to plug the hole. (blood.ca)
- If the injury to the vessel is large, platelets alone will not stop the bleeding, so they release other factors that start blood clotting. (blood.ca)
- Your blood pressure is the force of blood pushing against your blood vessel walls. (redcrossblood.org)
- When they find a damaged blood vessel, natural platelets bind to each other and signal other platelets to congregate at that spot. (cleveland.com)
- Platelets stop bleeding by clumping and forming plugs in blood vessel injuries. (express.co.uk)
- In this study, scientists from the Antibodies in Therapy and Pathology Unit (Institut Pasteur/Inserm U1222) revealed that platelets, whose best-known function is to stop bleeding when a blood vessel becomes damaged, play a key role in IgG-dependent anaphylactic reactions. (pasteur.fr)
- The platelets attach to the damaged part of the blood vessel and become activated. (healthhype.com)
- These changes occur within seconds of blood vessel damage and expedites the rest of the clotting process. (healthhype.com)
- Although platelets are the first to respond to blood vessel injury, it cannot repair the breaks permanently. (healthhype.com)
Centers4
- Community Blood Centers of Florida locations were inspected from September to December 2011, during which time staff found dangerous "deviations" from health protocol , according to letter sent in April and first reported by the South Florida Sun-Sentinel . (huffingtonpost.com)
- The non-profit operates 15 donor centers in Palm Beach, Broward, Miami-Dade and Monroe Counties, and 50 blood mobiles also travel throughout South Florida and Central Florida. (huffingtonpost.com)
- Bruce Blunt Jr. is alive today because of Ron Howard, the most prolific donor in the history of Florida's Blood Centers and possibly one of the top in the nation. (parade.com)
- The UCLA Blood & Platelet Center has two donor centers along with several community blood drives in your neighborhood. (uclahealth.org)
20182
- Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis, Science Immunology , April 13, 2018. (pasteur.fr)
- I came on board the Gulf Coast Regional Blood Center in February 2018. (giveblood.org)
Bone9
- 1) INTERFERON treatment causes a RAPID AND SUSTAINED reduction in peripheral platelet count by causing bone marrow suppression of platelets. (dailystrength.org)
- Polycythemia is the blood illness where bone marrow makes too many red and white blood cells and too many platelets. (sun-sentinel.com)
- These include failure to produce new platelets in the bone marrow, premature destruction of circulating platelets often by the body's own immune system, sequestration or storing of platelets in organs, and consumption of platelets at a rate that exceeds production in the bone marrow. (petplace.com)
- Bone marrow aspiration to obtain a sample for laboratory analysis if there is concern that your dog's bone marrow may not be making adequate numbers of platelets or may have been invaded by cancer. (petplace.com)
- They are made in the bone marrow and released to the blood, and they stick together to form clotting. (ehow.co.uk)
- Blood platelets are formed in bone marrow when a parent cell, a megakaryocyte, sends out arm-like extensions called proplatelets. (eurekalert.org)
- has to go thro bone marrow transplantation and he needs A+ blood platelets on urgent basis. (experienceproject.com)
- Stem cells are unique cells located in bone marrow or peripheral blood that can develop into red blood cells, white blood cells, and platelets. (blausen.com)
- That's because individuals undergoing chemotherapy and radiation therapy typically lose the ability to make platelets in their bone marrow. (statnews.com)
Cells46
- Unlike other blood components such as red cells, which are refrigerated, platelets must be stored at room temperature to remain effective, but. (wsj.com)
- The innate immune response is particularly important in fighting malaria, which causes symptoms once the parasite has invaded the victim s red blood cells. (webwire.com)
- So they conducted similar experiments in a Petri dish in which they added human platelets to red blood cells infected with Plasmodium falciparum, the most deadly human malaria parasite. (webwire.com)
- We believe that s because platelets bind to infected red blood cells and are taken out of circulation because of that, Foote said. (webwire.com)
- Blood platelets are deceptively simple cells. (springer.com)
- However, as late as 1957 some workers still believed that platelets were products of other cells, such as the erythrocyte (Leiter, 1976). (springer.com)
- Surprisingly, Campbell and his colleagues didn't detect evidence of the virus in the vast majority of platelets, suggesting that it could be promoting the genetic changes within these cells indirectly. (news-medical.net)
- Uncovering the fundamental mechanisms of how platelets respond as aggregates vs individual cells provides the foundation for understanding the many roles of platelets beyond hemostasis. (bloodjournal.org)
- Platelets are about a quarter of the size of red blood cells and are not whole cells but rather fragile cell fragments. (blood.ca)
- Platelets are blood cells that help control bleeding. (sandiegobloodbank.org)
- This yellow liquid in the blood carries the RBCs, platelets, and cells or proteins, like antibodies, that help fight infections. (cancer.net)
- 4. Histological examination of the lungs with a technique adequate to give a differential staining of platelet material demonstrates the presence of giant cells in the lungs, and supports the view that they are active in the production of platelets. (rupress.org)
- 5. In extrauterine life giant cells are concentrated in the marrow and the lungs, with the maximum of their activity in platelet production in the lungs. (rupress.org)
- The platelet also lives for a much shorter period of time, about a week compared with 4 months for red cells, so they have to be processed much more quickly. (metafilter.com)
- SALT LAKE CITY -- In a discovery that upends a longstanding tenet of human biology, University of Utah School of Medicine researchers have shown that a key process in gene regulation can occur in human platelets, unique cells that are unusual because they don't have a nucleus (anucleate). (eurekalert.org)
- But using stem cells from human umbilical cord blood to engineer the precursor cell that forms platelets and platelets isolated from the blood of study subjects, the Utah researchers found that splicing also takes place in the cytoplasm of circulating platelets. (eurekalert.org)
- Finding that platelets can splice the IL-1â pre-mRNA was completely unexpected and emerged while the researchers were engaged in earlier studies of how platelets communicate with certain leukocytes (white blood cells). (eurekalert.org)
- Platelets are abundant cells that circulate in human blood and have many functions. (eurekalert.org)
- It prevents white blood cells, which defend the body against foreign substances, from detecting them. (cleveland.com)
- Without the coating, white blood cells would destroy them in less than half an hour, he said. (cleveland.com)
- Other components of the blood transport metabolic waste from the cells to the kidneys, nutrients from the digestive system to the cells, and hormones throughout the body. (scribd.com)
- If we do not have enough iron, our body makes fewer and smaller red blood cells, which means less hemoglobin, and therefore we do not get enough oxygen (WebMD, Iron Deficiency Anemia). (scribd.com)
- These my include a complete blood count to look at your red blood cells and an iron test that shows how much iron is in your blood. (scribd.com)
- This microscopic look at human blood reveals that nearly half of our blood is composed of red blood cells. (nih.gov)
- When your platelets are taken, additional red cells and/or plasma may also be collected. (sandiegobloodbank.org)
- T he U.S. Defense Department has awarded $3.5 million to a Cambridge, Mass., biotech that says it has figured out a way to make blood platelets from stem cells, a technology the military believes could be useful in treating battlefield and civilian casualties. (statnews.com)
- 1) You draw the athlete's blood, centrifuge it (i.e. rotate it) at high speed, separating the red blood cells (RBC) from the plasma. (speedendurance.com)
- 2) Your body will produce its own red blood cells to compensate from your blood loss. (speedendurance.com)
- 3) You store the packed red blood cells in a refrigerator or freezer (RBC have a 120 day lifecycle). (speedendurance.com)
- 4) Then just before competition, you re-inject the red blood cells back into your body. (speedendurance.com)
- In CLL, lymphocytes (small white blood cells found mostly in the lymph system) become cancerous. (merckmanuals.com)
- We have examined the interactions of hemoglobin containing liposomes and of liposomes composed of polymerizable phospholipids with blood cells and proteins. (dtic.mil)
- In a study published today in The Journal of Clinical Investigation , Craig Morrell, DVM, Ph.D., discovered another important function of platelets: Keeping immune cells in balance. (rochester.edu)
- These cells are about 10 times or more large than red blood cells. (healthhype.com)
- Platelets have a lifespan of about 5 to 9 days in the circulation and old platelets are removed from the bloodstream by phagocytes in the spleen and Kupffer cells in the liver. (healthhype.com)
- There is also minimal risk of iron depletion because red blood cells are returned to the donor. (nzblood.co.nz)
- If the patient has signs of anemia and studies show a low red blood cell (RBC) count, then red blood cells will be transfused. (blausen.com)
- These harvested red blood cells are called "packed red blood cells" or PRBCs. (blausen.com)
- I wonder why he has not giving you the Procrit shot that will boost those red blood cells fast. (cancer.org)
- Red blood cells that carry oxygen can be refrigerated and used for up to 42 days. (statnews.com)
- These cells extend long arms into nearby blood vessels. (statnews.com)
- Donated platelets, when separated from the other blood components, are a mix of young and old cells. (statnews.com)
- My group is developing a bioreactor that can make platelets from human stem cells. (statnews.com)
- Cedric Ghevaert and colleagues at the University of Cambridge are among academic groups developing a different method of making platelets from stem cells that holds substantial promise . (statnews.com)
- While my group is exposing stem cells to "outside-in" signals that help direct their differentiation toward platelets, Ghevaert's team is boosting the expression of key genes in the stem cells to effect "inside-out" signaling to drive the same differentiation process. (statnews.com)
- Some versions of platelets have had the white blood cells partially removed or been gamma irradiated which have specific benefits for certain populations. (wikipedia.org)
Increase platelet1
- For example, if a liver transplant patient has a low platelet count physicians may increase platelet levels before the transplant in order to limit rejection. (rochester.edu)
Human platelets1
- Fox, J. E. B., 19856, Linkage of a membrane skeleton to integral membrane glycoproteins in human platelets. (springer.com)
Body's6
- Similarly, if you bruise easily and always have, it may be due to another harmless condition of your body's blood. (ehow.co.uk)
- Pawlowski has spent much of her career studying platelets, part of the body's rapid defense force that swings into action when the body suffers anything from a paper cut to a severed leg. (cleveland.com)
- The blood serves as the body's major transport system. (scribd.com)
- Platelets are the blood component serving as the body's "bandages. (dana-farber.org)
- The platelets that release proteins and other particles are used in the body's self-healing process. (speedendurance.com)
- In the last five to 10 years, scientists have found that platelets either initiate or accelerate the body's immune response in a wide range of inflammatory diseases, including atherosclerosis (when plaque builds up inside the arteries), arthritis and transplant rejection. (rochester.edu)
Donations to go uncollected2
- More than 550 blood drives have been forced to cancel due to winter weather in January, causing over 16,500 blood and platelet donations to go uncollected through last week. (kold.com)
- The shortfall follows more than 26,400 uncollected blood and platelet donations in February because of severe weather across 27 states.In the River Valley Blood Blood Services Region, approximately 81 blood drives were canceled, causing more than 2,300 blood and nearly 50 platelet donations to go uncollected. (wlky.com)
Chemotherapy2
- If your low platelet count is caused by the treatment for hepatitis C or by chemotherapy, a doctor will likely reduce the amount you are receiving and monitor platelets carefully. (ehow.co.uk)
- Many of them will need blood - sometimes daily - during their chemotherapy treatment. (cityofhope.org)
Becoming a platelet donor1
- If you are interested in becoming a platelet donor please take our Platelet Eligibility Quiz or call 01 4322833 (Dublin) or 021 4807429 (Cork) to speak to one of our staff. (giveblood.ie)
Bloodstream7
- Platelets in the bloodstream contain factors that are like nannies for vascular development. (news-medical.net)
- But babies who are born prematurely consume much of their platelets in connection with infections, and an imbalance of these factors arises in the bloodstream and out in the tissue that can lead to pathological vascular development, in this case in the retina,' Ann Hellstrom explains. (news-medical.net)
- Platelets bud off from these extensions, separating from the cell body and nucleus, and mature platelets then enter the bloodstream. (eurekalert.org)
- That's the question that Case Western Reserve University scientists answered by developing SynthoPlate, very tiny nanoparticles that, when injected into the bloodstream, mimic how platelets cluster to stop uncontrolled bleeding from various kinds of major trauma. (cleveland.com)
- Artificial platelets remain in the bloodstream for two to three days. (cleveland.com)
- Unlike blood doping, where it is injected into the bloodstream, the platelet-rich plasma is injected directly to the surrounding injury area and not into the bloodstream. (speedendurance.com)
- Extra platelets are stored in the spleen while the remaining platelets circulate in the bloodstream. (healthhype.com)
Antibodies9
- This blood test shows if you have antibodies against platelets in your blood. (medlineplus.gov)
- In the case of platelet antibodies, your body created antibodies to attack platelets. (medlineplus.gov)
- This means that you do not have anti-platelet antibodies in your blood. (medlineplus.gov)
- Abnormal results show that you have anti-platelet antibodies. (medlineplus.gov)
- The blood is also checked for any unexpected red blood cell antibodies that may cause problems for a recipient, as well as for diseases that could spread to recipients. (cancer.net)
- The experimental parts of the study, conducted at Harvard Medical School in Boston, indicate that the pathological vascular development in the retina of young mice increased by 30 percent when platelet levels were lowered by means of antibodies. (news-medical.net)
- While it was already known that IgE antibodies can trigger these allergic reactions, scientists from the Institut Pasteur, Inserm, the CNRS and EFS Grand Est recently demonstrated that IgG antibodies play an active role in the severity of anaphylactic shock by unexpectedly activating blood platelets. (pasteur.fr)
- To study the role of platelets in anaphylaxis, the scientists used transgenic mice expressing human receptors for IgG antibodies, since mice do not have these receptors on their platelets. (pasteur.fr)
- Injecting these mice with human IgG antibodies triggered an anaphylactic reaction, characterized by a drop in body temperature and leading to a significant reduction in the circulating platelet count that lasted for several hours after the shock, suggesting that platelets might play a role in the allergic reaction. (pasteur.fr)
Count32
- Due to low white blood count, I am careful about exposing self to anyone sick. (dailystrength.org)
- It is too low for any treatment, but the doctor said in the next couple of months there will be a new trial coming out to increase the platelet count, but there are no guarantees. (dailystrength.org)
- The addition of RIBAVIRIN actually HELPS sustain the platelet count. (dailystrength.org)
- Dear Dr. Donohue: I had blood work done six months ago, and my platelet count was 470,000. (sun-sentinel.com)
- When a patient has a high platelet count and no symptoms, treatment can be withheld. (sun-sentinel.com)
- When symptoms do appear, then hydroxyurea or anagrelide can usually restore a normal platelet count. (sun-sentinel.com)
- An organic diet rich in nutrients can have a beneficial effect on someone's platelet count. (reference.com)
- In a scientific study of mice with a blood platelet disorder, those who consumed 32 percent fewer calories had an improved platelet count and a longer lifespan. (reference.com)
- The National Heart, Lung, and Blood Institute shows normal ranges for the most common values detected on a blood test, including red blood cell count, whit. (reference.com)
- In healthy adults, the normal blood platelet count is 150,000 to 400,000 platelets per microliter of blood, according to MedlinePlus. (reference.com)
- In general, the lower the platelet count, the more likely bleeding is to occur. (petplace.com)
- The main symptom of low blood platelet count is bleeding, which can present itself in many ways. (ehow.co.uk)
- Both purpura and petechiae are visible signs of a low blood platelet count. (ehow.co.uk)
- People also may suffer from low platelet count due to a chronic liver condition. (ehow.co.uk)
- If your low blood platelet count is due to ITP, you will likely be treated with immunosuppressants, which hinder the immune system from destroying platelets. (ehow.co.uk)
- The study, now published online in The British Journal of General Practice, revealed that high blood platelet count in some cases may be the only outward indication of cancer. (thefreedictionary.com)
- TEHRAN (FNA)- Having a high blood platelet count is a strong predictor of cancer and should be urgently investigated to save lives, according to a large-scale study. (thefreedictionary.com)
- Initial blood tests performed in the West Bank revealed a low blood platelet count. (thefreedictionary.com)
- A normal platelet count is between 150 and 450 billion per liter for both men and women, according to Mayo Clinic. (reference.com)
- A platelet count that is lower or higher than normal is often a sign of an underlying medical condition, though it may also be a side effect of medication. (reference.com)
- A platelet count test is part of a complete blood count test, which also measures red blood cell count, hemoglobin, hematocrit and white blood cell count. (reference.com)
- When a platelet count is found to be outside the normal range, additional diagnostic testing is required to determine the cause. (reference.com)
- you should for sure ask about itp i also had it when i was younger and low platelet count is the biggest sign look out for any bruising or small red spots if he gets these you need to see your doctor asap. (healthboards.com)
- Conversely, increasing the platelet count in the blood resulted in a much worse allergic reaction. (pasteur.fr)
- High Blood Platelet count! (healthboards.com)
- Is DH's platelet count to high? (healthboards.com)
- Thrombocytosis is a condition where the platelet count in the blood is higher than normal. (healthhype.com)
- This is contradictory to what would be expected with a high platelet count. (healthhype.com)
- It is more likely to arise with an excessively high platelet count and an associated deficiency of another component of blood clotting known as von Willebrand factor (vWF). (healthhype.com)
- Blood groups: A or O ( Rh positive or negative)Your availability, the suitability of your veins and platelet count are also factors we need to consider before accepting you as a platelet donor. (nzblood.co.nz)
- There is now evidence that using a high platelet count threshold (50 x 109/L) increases the risk of death or bleeding compared to a lower platelet count threshold (25 x 109/L) in premature neonates. (wikipedia.org)
- Guidelines recommend that it is safe to perform central venous catheter insertion when the platelet count is 20 x 109/L or above. (wikipedia.org)
Apheresis6
- The actual technical name for the platelet process is 'apheresis,'" said Nokamura. (boiseweekly.com)
- An apheresis machine separates anticoagulated blood into components with retention of the platelets and a portion of plasma to create a standard adult dose of apheresis plateletes. (transfusion.com.au)
- When requested, an apheresis platelet unit can be further divided into four packs of equal volume to produce paediatric apheresis platelet components. (transfusion.com.au)
- Both apheresis and pooled platelets are leucodepleted during or soon after collection and they are also irradiated before release from the Blood Service, unless other specific arrangements have been made with the receiving laboratory/institution. (transfusion.com.au)
- Apheresis platelets can be modified as phenotyped , CMV-seronegative and HLA-compatible , crossmatch-compatible and/or low anti-A/B . (transfusion.com.au)
- Platelets can be produced either from whole blood or by apheresis. (wikipedia.org)
Give blood or platelets1
- Make an appointment to give blood or platelets by downloading the free Red Cross Blood Donor App, visiting redcrossblood.org or calling 1-800-RED CROSS (1-800-733-2767). (kold.com)
Donor Center5
- Please contact the Kraft Family Blood Donor Center at 617.632.3206 or email us at [email protected] . (dana-farber.org)
- At the Kraft Family Blood Donor Center, located on the first floor of the Jimmy Fund Building at 35 Binney Street in Boston. (dana-farber.org)
- Please contact blood donor center with questions or if work on a specific procedure is ongoing. (dana-farber.org)
- Medications or medical conditions: Please contact the blood donor center. (dana-farber.org)
- Travel outside USA: If within 12 months, please contact the blood donor center with detailed dates and locations. (dana-farber.org)
Proteins5
- It contains a higher concentration of blood-clotting proteins than regular plasma. (cancer.net)
- During that investigation they found evidence of platelets making new proteins, which led them to pursue the mechanisms that are involved, said Guy A. Zimmerman, M.D., professor of internal medicine and one of the study's co-authors. (eurekalert.org)
- The idea that blood platelets could make proteins without having a nucleus had been thought heretical," said Zimmerman, who also heads the U's Program in Human Molecular Biology and Genetics at the Eccles Institute of Human Genetics. (eurekalert.org)
- Healing injuries involves a well orchestrated and complex series of events where proteins in the blood called growth factors act as messengers, regulating the entire process.There is a growing interest for Autologous blood products for use in a number of orthopaedic procedures. (arthrex.com)
- Interactions of Lipid Vesicles with Blood Proteins and Platelets. (dtic.mil)
Large number of platelets1
- In a healthy person, a large number of platelets are manufactured and stored in the body. (blood.ca)
Donate blood21
- Individuals who are 17 years of age (16 with parental consent in some states), weigh at least 110 pounds and are in generally good health may be eligible to donate blood. (redcross.org)
- BE A HERO THIS VALENTINE'S DAY Schedule an appointment to donate blood or platelets using the Red Cross Blood Donor App , visiting redcrossblood.org , or calling 1-800-RED CROSS (1-800-733-2767). (redcross.org)
- Individuals who are 17 years of age (16 with parental consent in most states), weigh at least 110 pounds and are in generally good health may be eligible to donate blood or platelets. (redcross.org)
- If you'd like to donate blood or platelets, a good first step is to find your local Red Cross blood drive or blood bank where you can donate. (cancer.net)
- Certain medications may delay your ability to donate blood. (mskcc.org)
- DO NOT discontinue medications prescribed or recommended by your physicians in order to donate blood. (mskcc.org)
- Hepatitis B Immune Globulin (HBIG) is an injected material used to prevent hepatitis B infection following a possible or known exposure to hepatitis B. HBIG does not prevent hepatitis B infection in every case, therefore, persons who have received HBIG must wait to donate blood. (mskcc.org)
- So if you're looking to give back this holiday season, consider taking an hour or so to donate blood and help save a life. (cityofhope.org)
- Am I Eligible to Donate Blood? (redcrossblood.org)
- Find out about the eligibility requirements to donate blood today. (redcrossblood.org)
- Helping Hurricane Harvey victims: Donate blood, platelets & plasma! (whnt.com)
- If you'd like to donate blood, you can find locations and times for Life South here and for the American Red Cross here . (whnt.com)
- You may donate blood if it has been more than 12 months since incarceration or sexual contact with someone who was incarcerated. (mskcc.org)
- You may not donate blood if you have used illegal intravenous drugs or if you take anabolic steroids intravenously (unless you have a doctor's prescription) in the past 3 months . (mskcc.org)
- It is medically safe to donate blood about every 60 days, plasma once a month and platelets every one or two weeks. (whig.com)
- Anyone who can donate blood or platelets please turn out. (911families.org)
- To make an appointment to donate blood or platelets, please call 212-639-8177 or 212-639-7648. (911families.org)
- One way of addressing this problem would be to get more people to donate blood, although I'm not sure how realistic that is. (statnews.com)
- About 7 million people already donate blood in the U.S. each year. (statnews.com)
- I regularly donate blood, I did on my last cycle(androhard/tbol) like nos said if they see something they don't like they'll toss it, there main concentrate is HIV, and hepatitis. (anabolicminds.com)
- To donate blood, individuals must meet minimum age requirements (16-year-olds in Oregon need parental consent, 16-and 17-year-olds in Washington need parental consent), weigh at least 110 pounds and be generally healthy. (salem-news.com)
Shelf life6
- Artificial platelets have a longer shelf life, allowing first-responders and more hospitals could keep them on hand. (cleveland.com)
- Platelets can be irradiated at any stage during their 5 day storage and thereafter can be stored up to their normal shelf life of 5 days after collection. (transfusion.com.au)
- With a shelf life of just five days, platelet donations are especially needed. (wlky.com)
- Platelets have a shelf life of 5 days. (sandiegobloodbank.org)
- But platelets - the Band-Aids of the body that stop bleeding - have a shelf life of only two days after they are screened for disease. (statnews.com)
- Given their short shelf life, platelets must be screened for bacteria and viruses quickly, and immediately delivered to individuals who need them. (statnews.com)
Detected platelet dysfunction1
- Whole blood platelet analysis detected platelet dysfunction which may be associated with bleeding and thrombotic risks in uremia. (hindawi.com)
Aspirin7
- New studies in mice suggest that blood platelets can destroy deadly malaria parasites, but a single dose of aspirin may be enough to thwart their killing power. (webwire.com)
- To ensure that their original observation was not due to other genetic changes caused by knocking out the Mpl gene, the researchers eliminated platelets by giving the mice aspirin, which inactivates platelets. (webwire.com)
- Although there is more work to do, the researchers believe that the aspirin is preventing some sort of anti-malarial effect produced by the platelets. (webwire.com)
- And when aspirin was added, the platelets no longer held back the parasites. (webwire.com)
- Platelet samples came from another 2,000 similar participants, including 800 blacks, enrolled in the Genetic Study of Aspirin Responsiveness (GeneSTAR) under way at Johns Hopkins since 2002 and led by Becker's wife and study co-investigator Diane Becker, M.P.H., Sc.D., a professor at the both Hopkins' School of Medicine and the University's Bloomberg School of Public Health. (scienceblog.com)
- Lewis Becker says the teams' next steps are to test various platelet antagonists, or blood-thinning agents, like aspirin, the most common drug treatment in heart and vascular diseases, to find out precisely which hereditary factors may distinguish people who are so-called aspirin-resistant or not, and why the medication works for most but not all. (scienceblog.com)
- Please be sure to not consume aspirin in the 48 hours prior to donating platelets. (sandiegobloodbank.org)
Inflammation5
- Hepatitis C is a blood-borne viral disease which can cause liver inflammation, fibrosis, cirrhosis and liver cancer. (dailystrength.org)
- They also noted that these changes significantly altered how platelets interacted with the immune system, likely contributing to inflammation of the respiratory tract that may, in turn, result in more severe lung injury. (news-medical.net)
- 2 More recently, there is a growing appreciation for the critical role platelets have in maintaining vascular integrity during development and inflammation. (bloodjournal.org)
- Our main goal is to dissect the molecular and mechanical cues regulating platelet cytoskeleton dynamics and platelet motility in the context of thrombosis and inflammation. (uni-muenchen.de)
- The U researchers, who report their findings in the Aug. 12 edition of Cell, also identified the pre-mRNA in blood platelets that codes for Interleukin 1â (IL-1â), a key protein in an ancient molecular system that plays major roles in inflammation, defense against infection, organ development, and disease. (eurekalert.org)
20171
- Information is based on the typical unit content (mean ± 1 SD) from Blood Service data (1 January to 31 December 2017 inclusive) and acceptable specification limits (in parentheses). (transfusion.com.au)
Immune system3
- Previous studies have shown that platelets are active in the body s innate immune system, which responds rapidly to invading pathogens. (webwire.com)
- Corticosteroids (cortisone-like drugs) are often used to stop the immune system from destroying platelets. (petplace.com)
- as a suggestion, at printout all the research about immune system and blood trasfusions. (cancer.org)
High Blood Platelets1
- What Are High Blood Platelets a Sign Of? (reference.com)
Person's3
- The hepatitis C virus (HCV) is spread by blood-to-blood contact with an infected person's blood. (dailystrength.org)
- elimination of these foods from a person's diet can promote platelet buildup. (reference.com)
- In most instances this high levels of platelets does not pose any significant threat to the person's health. (healthhype.com)
Various platelet1
- In another test, called a platelet function test, a sample of blood is collected and tested to see if platelets react normally to various platelet stimulators. (merckmanuals.com)
Plasma and platelets2
- Fresh frozen plasma and platelets, if transfused unnecessarily, it can lead to reactions. (hindustantimes.com)
- After they reach their local quota, they'll send extra pints of blood, plasma and platelets down to the Greater Houston area. (whnt.com)
Enough platelets1
- But there are never enough platelets to help everyone who needs them, largely because of their ephemeral nature. (statnews.com)
Circulate in human blood1
- Approximately 750 billion platelets circulate in human blood, constantly scanning the vasculature for damage of the endothelial surface. (uni-muenchen.de)
Gift of platelets1
- Your gift of platelets is worth the wait! (sandiegobloodbank.org)
Production of platelets1
- Platelet BioGenesis, which was founded in 2014, said Wednesday that the grant will help the startup develop a bioreactor that is key to the production of platelets, a critical component of blood that promotes clotting. (statnews.com)
Levels of platelets2
- The current study points to a correlation between low levels of platelets, whose main task in adults is to inhibit bleeding in blood vessels, and a fourfold increased risk of severe ROP in infants. (news-medical.net)
- This leads to high levels of platelets in the circulation. (healthhype.com)
Contamination of platelets1
- The biggest risk in the nation's blood supply is no longer HIV or hepatitis C, it's bacterial contamination of platelets, resulting in at least 20 deaths and hundreds of adverse reactions in recent years, health experts say. (wsj.com)
Vessels4
- In experiments on mice, injections of blood platelets reduce the pathological development of retinal vessels. (news-medical.net)
- Their primary role is to form "plugs" that stop bleeding from injured blood vessels. (eurekalert.org)
- When the inner lining of blood vessels (endothelium) is damaged, platelets are one of the first blood components to respond. (healthhype.com)
- Low-risk procedures include surgical sites that do not contain many blood vessels e.g. cataract surgery, or minor procedures. (wikipedia.org)
Single platelet1
- We recently developed imaging based tools to visualize these processes on a single platelet level in vitro and in vivo . (uni-muenchen.de)
Thrombocytosis4
- The condition in which there are too many platelets is thrombocytosis. (sun-sentinel.com)
- That means you have essential thrombocytosis, an increased number of platelets without known cause. (sun-sentinel.com)
- Having too many platelets in the blood is a sign of either thrombocytosis or thrombocythemia. (reference.com)
- In thrombocytosis, the number of platelets produced is higher than normal and these platelets have a longer lifespan. (healthhype.com)
Disorder7
- Low platelets can be the result of an autoimmune problem, so I was wondering if petechiae could be another disorder from celiac. (celiac.com)
- According to the Platelet Disorder Support Association, a change in diet can help build up blood platelets. (reference.com)
- The Platelet Disorder Support Association suggests eating fruits and vegetables and eliminating harmful foods that contain few nutrients, vitamins or minerals. (reference.com)
- While most high school seniors were preparing to go off to college, Briana was fighting for her life against a rare blood disorder, called severe aplastic anemia. (giveblood.org)
- Also searched for Platelet disorder . (clinicaltrials.gov)
- Chronic lymphocytic leukemia (CLL) is a generally slow-growing blood disorder. (merckmanuals.com)
- Von Willebrand disease is the most common inherited platelet-related disorder. (merckmanuals.com)
Abnormal1
- Abnormal platelet function tests may indicate the nature of the inherited or acquired platelet dysfunction. (merckmanuals.com)
Extra platelets1
- Because the body manufactures and stores extra platelets, the platelets collected during the procedure will be replaced almost immediately. (blood.ca)
Normal platelets2
- During those studies, they discovered that platelet-deficient mice were much more likely to die of malaria than mice with normal platelets. (webwire.com)
- Platelet dysfunction may be due to a problem in the platelets themselves or to an external factor that alters the function of normal platelets. (merckmanuals.com)
Function8
- The reason bleeding occurs lies in the fact that the numerous platelets don't function normally. (sun-sentinel.com)
- At present, blood banks function like business units, they supply blood and its components according to the demand. (hindustantimes.com)
- In what is believed to be the largest review of the human genetic code to determine why some people's blood platelets are more likely to clump faster than others, scientists at Johns Hopkins and in Boston have found a septet of overactive genes, which they say likely control that bodily function. (scienceblog.com)
- Statin drugs alter platelet function. (greenmedinfo.com)
- As a biomedical engineer, she was fascinated with how platelets function, and the idea that scientists could build something to mimic them. (cleveland.com)
- To confirm their function, the scientists eliminated the platelets from the blood, which led to a reduction in symptoms. (pasteur.fr)
- When platelets do not function properly, people are at risk of excessive bleeding due to injuries or even spontaneous bleeding. (merckmanuals.com)
- Its function is to carry oxygen-rich blood from the heart to the rest of the body. (blausen.com)
Billion platelets1
- Average healthy adults produce some 100 billion platelets each day. (healthhype.com)
Microliter of blood1
- Dogs with blood platelet concentrations of less than 40,000 per microliter of blood are at risk for spontaneous bleeding. (petplace.com)
Occurs2
- Bacterial contamination of platelet components occurs because the storage temperature for platelets (22° C) may facilitate bacterial growth. (cdc.gov)
- However, a similar reaction occurs in people who are given heparin, which triggers extreme blood clotting that depletes their platelets. (express.co.uk)
Urgent need1
- There is also an urgent need for platelet donations. (whig.com)