Blood platelets. Medical search

Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.

The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.

The number of PLATELETS per unit volume in a sample of venous BLOOD.

The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other "foreign" surfaces.

Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.

A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.

An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.

Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.

The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.

A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.

Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.

Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.

Very large BONE MARROW CELLS which release mature BLOOD PLATELETS.

A platelet-specific protein which is released when platelets aggregate. Elevated plasma levels have been reported after deep venous thrombosis, pre-eclampsia, myocardial infarction with mural thrombosis, and myeloproliferative disorders. Measurement of beta-thromboglobulin in biological fluids by radioimmunoassay is used for the diagnosis and assessment of progress of thromboembolic disorders.

A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.

Disorders caused by abnormalities in platelet count or function.

A subnormal level of BLOOD PLATELETS.

A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.

Laboratory examination used to monitor and evaluate platelet function in a patient's blood.

Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.

2-Octylcyclopentaneheptanoic acids. The family of saturated carbon-20 cyclic fatty acids that represent the parent compounds of the prostaglandins.

Cell adhesion molecule and CD antigen that mediates the adhesion of neutrophils and monocytes to activated platelets and endothelial cells.

A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.

The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)

The process of generating thrombocytes (BLOOD PLATELETS) from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via the MEGAKARYOCYTES. The humoral factor with thrombopoiesis-stimulating activity is designated THROMBOPOIETIN.

A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).

The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.

An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).

The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.

The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.

Human alloantigens expressed only on platelets, specifically on platelet membrane glycoproteins. These platelet-specific antigens are immunogenic and can result in pathological reactions to transfusion therapy.

Formation and development of a thrombus or blood clot in the blood vessel.

A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow MEGAKARYOCYTES and their release of blood platelets. The process is called THROMBOPOIESIS.

Condensed areas of cellular material that may be bounded by a membrane.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

An opioid analgesic chemically related to and with an action resembling that of MEPERIDINE, but more rapid in onset and of shorter duration. It has been used in obstetrics, as pre-operative medication, for minor surgical procedures, and for dental procedures. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1067)

Physiologically active compounds found in many organs of the body. They are formed in vivo from the prostaglandin endoperoxides and cause platelet aggregation, contraction of arteries, and other biological effects. Thromboxanes are important mediators of the actions of polyunsaturated fatty acids transformed by cyclooxygenase.

A mixture of the mesylates (methane sulfonates) of DIHYDROERGOCORNINE; DIHYDROERGOCRISTINE; and the alpha- and beta-isomers of DIHYDROERGOCRYPTINE. The substance produces a generalized peripheral vasodilation and a fall in arterial pressure and has been used to treat symptoms of mild to moderate impairment of mental function in the elderly.

A phosphodiesterase inhibitor which inhibits platelet aggregation. Formerly used as an antineoplastic.

The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).

A plant genus of the family ROSACEAE. The common names of chokeberry or chokecherry are also used for some species of PRUNUS.

A deficiency or absence of FIBRINOGEN in the blood.

Duration of blood flow after skin puncture. This test is used as a measure of capillary and platelet function.

A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS.

A tricyclic antidepressant that has actions and uses similar to those of AMITRIPTYLINE, but has only weak antimuscarinic and sedative effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p257)

Cell surface proteins that bind THROMBOXANES with high affinity and trigger intracellular changes influencing the behavior of cells. Some thromboxane receptors act via the inositol phosphate and diacylglycerol second messenger systems.

The rate dynamics in chemical or physical systems.

Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.

A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.

The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.

Platelet membrane glycoprotein IIb is an integrin alpha subunit that heterodimerizes with INTEGRIN BETA3 to form PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX. It is synthesized as a single polypeptide chain which is then postranslationally cleaved and processed into two disulfide-linked subunits of approximately 18 and 110 kDa in size.

A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).

The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

A phospholipid from the platelet membrane that contributes to the blood clotting cascade by forming a phospholipid-protein complex (THROMBOPLASTIN) which serves as a cofactor with FACTOR VIIA to activate FACTOR X in the extrinsic pathway of BLOOD COAGULATION.

The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.

Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.

An organization of cells into an organ-like structure. Organoids can be generated in culture. They are also found in certain neoplasms.

Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.

The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.

An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.

Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.

Elements of limited time intervals, contributing to particular results or situations.

A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.

An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.

An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.

Cell surface receptors that are specific for THROMBOPOIETIN. They signal through interaction with JANUS KINASES such as JANUS KINASE 2.

A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.

An ergot derivative that is a congener of LYSERGIC ACID DIETHYLAMIDE. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle, but has few of the properties of other ergot alkaloids. Methysergide is used prophylactically in migraine and other vascular headaches and to antagonize serotonin in the carcinoid syndrome.

Field of chemistry that pertains to immunological phenomena and the study of chemical reactions related to antigen stimulation of tissues. It includes physicochemical interactions between antigens and antibodies.

The sum of the weight of all the atoms in a molecule.

A subclass of purinergic P2Y receptors that have a preference for ADP binding and are coupled to GTP-BINDING PROTEIN ALPHA SUBUNIT, GI. The P2Y12 purinergic receptors are found in PLATELETS where they play an important role regulating PLATELET ACTIVATION.

Cell surface receptors that bind prostaglandins with high affinity and trigger intracellular changes which influence the behavior of cells. Prostaglandin receptor subtypes have been tentatively named according to their relative affinities for the endogenous prostaglandins. They include those which prefer prostaglandin D2 (DP receptors), prostaglandin E2 (EP1, EP2, and EP3 receptors), prostaglandin F2-alpha (FP receptors), and prostacyclin (IP receptors).

Organic compounds that contain 1,2-diphenylethylene as a functional group.

Antibodies produced by a single clone of cells.

Disorder characterized by a decrease or lack of platelet dense bodies in which the releasable pool of adenine nucleotides and 5HT are normally stored.

A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.

An antibiotic mixture of two components, A and B, obtained from Nocardia lurida (or the same substance produced by any other means). It is no longer used clinically because of its toxicity. It causes platelet agglutination and blood coagulation and is used to assay those functions in vitro.

Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.

A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and impaired or absent clot retraction. Platelet membranes are deficient in or have a defect in the glycoprotein IIb-IIIa complex (PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX).

The relationship between the dose of an administered drug and the response of the organism to the drug.

A protein factor that regulates the length of R-actin. It is chemically similar, but immunochemically distinguishable from actin.

Peptides composed of between two and twelve amino acids.

Any form of purpura in which the PLATELET COUNT is decreased. Many forms are thought to be caused by immunological mechanisms.

Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.

The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.

Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.

A dynamic actin-rich extension of the surface of an animal cell used for locomotion or prehension of food.

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.

An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.

A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID.

The quantity of volume or surface area of CELLS.

A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Increased numbers of platelets in the peripheral blood. (Dorland, 27th ed)

Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.

Endogenous substances, usually proteins, that are involved in the blood coagulation process.

A preparation consisting of PLATELETS concentrated in a limited volume of PLASMA. This is used in various surgical tissue regeneration procedures where the GROWTH FACTORS in the platelets enhance wound healing and regeneration.

A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin).

Adherence of cells to surfaces or to other cells.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Synthetic compounds that are analogs of the naturally occurring prostaglandin endoperoxides and that mimic their pharmacologic and physiologic activities. They are usually more stable than the naturally occurring compounds.

Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)

Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).

The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.

Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.

Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.

Stable carbon atoms that have the same atomic number as the element carbon, but differ in atomic weight. C-13 is a stable carbon isotope.

Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.

The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).

A familial coagulation disorder characterized by a prolonged bleeding time, unusually large platelets, and impaired prothrombin consumption.

Proteins prepared by recombinant DNA technology.

Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.

A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.

A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.

A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.

The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)

A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

The preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor.

A calcium-activated enzyme that catalyzes the hydrolysis of ATP to yield AMP and orthophosphate. It can also act on ADP and other nucleoside triphosphates and diphosphates. EC 3.6.1.5.

Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)

A metallic element, atomic number 49, atomic weight 114.82, symbol In. It is named from its blue line in the spectrum. (From Dorland, 28th ed)

Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.

Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI.

Proteins that bind specific drugs with high affinity and trigger intracellular changes influencing the behavior of cells. Drug receptors are generally thought to be receptors for some endogenous substance not otherwise specified.

An absence of warmth or heat or a temperature notably below an accustomed norm.

The deformation and flow behavior of BLOOD and its elements i.e., PLASMA; ERYTHROCYTES; WHITE BLOOD CELLS; and BLOOD PLATELETS.

The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)

Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.

A family of related, adhesive glycoproteins which are synthesized, secreted, and incorporated into the extracellular matrix of a variety of cells, including alpha granules of platelets following thrombin activation and endothelial cells. They interact with a number of BLOOD COAGULATION FACTORS and anticoagulant factors. Five distinct forms have been identified, thrombospondin 1, -2, -3, -4, and cartilage oligomeric matrix protein (COMP). They are involved in cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, VASCULAR SMOOTH MUSCLE growth, and tissue repair.

A rare, inherited platelet disorder characterized by a selective deficiency in the number and contents of platelet alpha-granules. It is associated with THROMBOCYTOPENIA, enlarged platelets, and prolonged bleeding time.

Bleeding or escape of blood from a vessel.

Values of three coagulation screening tests of precolostral calves. (1/11030)

Prothrombin times, partial thromboplastin times and platelet counts were performed to determine normal values and to screen for coagulation defects of precolostral calves. The precolostral calves were in two groups: one group of a few calves was tested two years before the second larger group. The results for both groups were similar. The tests were performed on postcolostral calves and on mature cows to compare their values with those of precolostral calves. The mean values of prothrombin times and partial thromboplastin times of precolostral calves in the first group were 18.8 seconds and 54.8 seconds respectively. The mean values of prothrombin times and partial thromboplastin times of precolostral calves in the second group were 18.8 seconds and 50.8 seconds respectively. The mean platelet count was 422,400/cmm for the first group and 482,800/cmm for the second group. (+info)

Enhanced myocardial glucose use in patients with a deficiency in long-chain fatty acid transport (CD36 deficiency). (2/11030)

CD36 is a multifunctional, 88 kDa glycoprotein that is expressed on platelets and monocytes/macrophages. CD36 also has high homology with the long-chain fatty acid (LFA) transporter in the myocardium. Although platelet and monocyte CD36 levels can indicate a CD36 deficiency, they cannot predict specific clinical manifestations in the myocardium of a given person. We examined the hypothesis that a deficiency in LFA transport augments myocardial glucose uptake in patients with a type I CD36 deficiency. METHODS: Seven fasting patients with a type I CD36 deficiency and 9 controls were assessed by cardiac radionuclide imaging using beta-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) as a LFA tracer and by PET with 18F-fluorodeoxyglucose (FDG). RESULTS: None of the patients with a CD36 deficiency showed myocardial uptake of BMIPP. The percentage dose uptake of BMIPP in these subjects was significantly lower than that in normal controls (1.31+/-0.24 versus 2.90+/-0.2; P < 0.005). PET studies revealed that myocardial FDG accumulation was substantially increased in patients with a CD36 deficiency. Quantitative analysis showed that the percentage dose uptake of FDG in patients with a CD36 deficiency was significantly higher than that in normal controls (1.28+/-0.35 versus 0.43+/-0.22; P< 0.01). CONCLUSION: CD36 functions as a major myocardial LFA transporter and its absence may cause a compensatory upregulation of myocardial glucose uptake. (+info)

Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. (3/11030)

Collagen-related peptide (CRP), a collagen homologue, induces platelet activation through a tyrosine kinase-dependent pathway, leading to sequential tyrosine phosphorylation of Fc receptor (FcR) gamma-chain, Syk, and phospholipase C-gamma2. Here we report that CRP and the platelet low affinity immune receptor FcgammaRIIA stimulate tyrosine phosphorylation of the T cell adapter SLP-76, whereas the G protein-coupled receptor agonist thrombin induces only minor tyrosine phosphorylation. This suggests that SLP-76 has a specific role downstream of receptors that signal via an immunoreceptor tyrosine-based activation motif. Immunoprecipitation studies demonstrate association of SLP-76 with SLAP-130, Vav, Fyn, Lyn, and the FcR gamma-chain in CRP-stimulated platelets. Several of these proteins, including SLP-76, undergo tyrosine phosphorylation in in vitro kinase assays performed on SLP-76 immunoprecipitates. Tyrosine phosphorylation of all of these proteins in the in vitro kinase assay was abrogated by the Src family kinase inhibitor PP1, suggesting that it is mediated by either Fyn or Lyn. The physiological significance of this is uncertain, however, since tyrosine phosphorylation of SLP-76 in vivo is not altered in either Fyn- or Lyn-deficient platelets. CRP stimulation of Syk-deficient platelets demonstrated that in vivo tyrosine phosphorylation of SLP-76 is downstream of Syk. The absence of Syk in the SLP-76 immunoprecipitates raises the possibility that another protein is responsible for bringing SLP-76 to Syk. Candidates for this include those proteins that co-immunoprecipitate with SLP-76, including the FcR gamma-chain. Tyrosine phosphorylation of PLC-gamma2 and Ca2+ mobilization is markedly attenuated in SLP-76-deficient platelets following CRP stimulation, suggesting that the adapter plays a critical role in the regulation of the phospholipase. The increase in tyrosine phosphorylation of SLAP-130 in response to CRP is also inhibited in SLP-76-deficient platelets, placing it downstream of SLP-76. This work identifies SLP-76 as an important adapter molecule that is regulated by Syk and lies upstream of SLAP-130 and PLC-gamma2 in CRP-stimulated platelets. (+info)

Changes in haematological parameters and iron metabolism associated with a 1600 kilometre ultramarathon. (4/11030)

OBJECTIVE: To investigate haematological variations and iron related changes in the serum of participants in a 1600 kilometre ultramarathon run. PARTICIPANTS: Seven male and two female participants in a 1600 km foot race. METHODS: Blood samples were obtained from the participants before, after four and 11 days of running, and at the end of the event. Samples were analysed by standard methods for haemoglobin, packed cell volume, total red cell count, mean red cell volume, mean red cell haemoglobin, total white cell count and differential, platelets, reticulocytes, iron, ferritin, total iron binding capacity, percentage transferrin saturation, haptoglobin, and bilirubin and corrected for changes in plasma volume. RESULTS: The following variables decreased during the event (p < 0.05): haemoglobin, packed cell volume, mean red cell volume, percentage lymphocytes, percentage monocytes, serum iron, total iron binding capacity, and percentage transferrin saturation. Increases (p < 0.05) were found in plasma volume, total red cell count (day 4 only), total white cell count, percentage and absolute numbers of neutrophils and reticulocytes, absolute numbers of lymphocytes and monocytes (day 4 only), absolute numbers of eosinophils (day 11 and race end), absolute numbers of basophils (race end only), platelets, ferritin, haptoglobin, and bilirubin (day 4 only). CONCLUSION: Ultramarathon running is associated with a wide range of changes in haematological parameters, many of which are related to the normal acute phase response to injury. These should not be confused with indicators of disease. (+info)

The Megakaryocyte/Platelet-specific enhancer of the alpha2beta1 integrin gene: two tandem AP1 sites and the mitogen-activated protein kinase signaling cascade. (5/11030)

The alpha2beta1 integrin, a collagen receptor on platelets and megakaryocytes, is required for normal platelet function. Transcriptional regulation of the alpha2 integrin gene in cells undergoing megakaryocytic differentiation requires a core promoter between bp -30 and -92, a silencer between bp -92 and -351, and megakaryocytic enhancers in the distal 5' flank. We have now identified a 229-bp region of the distal 5' flank of the alpha2 integrin gene required for high-level enhancer activity in cells with megakaryocytic features. Two tandem AP1 binding sites with dyad symmetry are required for enhancer activity and for DNA-protein complex formation with members of the c-fos/c-jun family. The requirement for AP1 activation suggested a role for the mitogen-activated protein kinase (MAPK) signaling pathway in regulating alpha2 integrin gene expression. Inhibition of the MAP kinase cascade with PD98059, a specific inhibitor of MAPK kinase 1, prevented the expression of the alpha2 integrin subunit in cells induced to become megakaryocytic. We provide a model of megakaryocytic differentiation in which expression of the alpha2 integrin gene requires signaling via the MAP kinase pathway to activate two tandem AP1 binding sites in the alpha2 integrin enhancer. (+info)

Activation of stimulus-specific serine esterases (proteases) in the initiation of platelet secretion. I. Demonstration with organophosphorus inhibitors. (6/11030)

The effect of organophosphorus inhibitors of serine esterases (proteases) on secretion from washed rabbit platelets was examined. Five noncytotoxic stimuli were employed: collagen, thrombin, heterologous anti-platelet antibody (in the absence of complement), rabbit C3 bound to zymosan, and platelet activating factor derived from antigen-stimulated, IgE-sensitized rabbit basophils. Diisoprophyl phosphofluoridate, three series of p-nitrophenyl ethyl phosphonates, and a series of cyclohexyl phenylalkylphosphonofluridates were all found to be inhibitory to the platelet secretion. These are irreversible inhibitors of serine proteases but in this system were only inhibitory if added to the platelets concurrently with the stimuli. Pretreatment of either the platelets or the stimuli with the inhibitors followed by washing, was without effect on the subsequent reaction. This suggested the involvement of stimulus-activatable serine proteases in the secretory process. The concept was supported by finding that nonphosphorylating phosphonates or hydrolyzed phosphonates or phosphonofluoridates were without inhibitory action. The effect of a series of phosphonates or phosphonoflouridates in inhibiting each stimulus exhibited a unique activity-structure profile. The demonstration of such unique profiles with four series of inhibitors for each of the five stimuli was interpreted as demonstrating that a specific activatable serine protease was involved in the platelet secretory response to each stimulus. (+info)

Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPib/actin-binding protein (ABP-280) interaction in maintaining adhesion under high shear. (7/11030)

Adhesion of platelets to sites of vascular injury is critical for hemostasis and thrombosis and is dependent on the binding of the vascular adhesive protein von Willebrand factor (vWf) to the glycoprotein (GP) Ib-V-IX complex on the platelet surface. A unique but poorly defined characteristic of this receptor/ligand interaction is its ability to support platelet adhesion under conditions of high shear stress. To examine the structural domains of the GPIb-V-IX complex involved in mediating cell adhesion under flow, we have expressed partial (GPIb-IX), complete (GPIb-V-IX), and mutant (GPIbalpha cytoplasmic tail mutants) receptor complexes on the surface of Chinese hamster ovary (CHO) cells and examined their ability to adhere to a vWf matrix in flow-based adhesion assays. Our studies demonstrate that the partial receptor complex (GPIb-IX) supports CHO cell tethering and rolling on a bovine or human vWf matrix under flow. The adhesion was specifically inhibited by an anti-GPIbalpha blocking antibody (AK2) and was not observed with CHO cells expressing GPIbbeta and GPIX alone. The velocity of rolling was dependent on the level of shear stress, receptor density, and matrix concentration and was not altered by the presence of GPV. In contrast to selectins, which mediate cell rolling under conditions of low shear (20-200 s-1), GPIb-IX was able to support cell rolling at both venous (150 s-1) and arterial (1500-10,500 s-1) shear rates. Studies with a mutant GPIbalpha receptor subunit lacking the binding domain for actin-binding protein demonstrated that the association of the receptor complex with the membrane skeleton is not essential for cell tethering or rolling under low shear conditions, but is critical for maintaining adhesion at high shear rates (3000-6000 s-1). These studies demonstrate that the GPIb-IX complex is sufficient to mediate cell rolling on a vWf matrix at both venous and arterial levels of shear independent of other platelet adhesion receptors. Furthermore, our results suggest that the association between GPIbalpha and actin-binding protein plays an important role in enabling cells to remain tethered to a vWf matrix under conditions of high shear stress. (+info)

Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. (8/11030)

Platelets respond to various stimuli with rapid changes in shape followed by aggregation and secretion of their granule contents. Platelets lacking the alpha-subunit of the heterotrimeric G protein Gq do not aggregate and degranulate but still undergo shape change after activation through thromboxane-A2 (TXA2) or thrombin receptors. In contrast to thrombin, the TXA2 mimetic U46619 led to the selective activation of G12 and G13 in Galphaq-deficient platelets indicating that these G proteins mediate TXA2 receptor-induced shape change. TXA2 receptor-mediated activation of G12/G13 resulted in tyrosine phosphorylation of pp72(syk) and stimulation of pp60(c-src) as well as in phosphorylation of myosin light chain (MLC) in Galphaq-deficient platelets. Both MLC phosphorylation and shape change induced through G12/G13 in the absence of Galphaq were inhibited by the C3 exoenzyme from Clostridium botulinum, by the Rho-kinase inhibitor Y-27632 and by cAMP-analogue Sp-5,6-DCl-cBIMPS. These data indicate that G12/G13 couple receptors to tyrosine kinases as well as to the Rho/Rho-kinase-mediated regulation of MLC phosphorylation. We provide evidence that G12/G13-mediated Rho/Rho-kinase-dependent regulation of MLC phosphorylation participates in receptor-induced platelet shape change. (+info)

A decrease in blood platelets (thrombocytopenia) also may occur. Since platelets are important for the clotting of blood, ... One possible side effect is agranulocytosis, a decrease of white blood cells in the blood. Symptoms and signs of ... Other severe side effects include liver problems and low blood cell counts. Use during pregnancy may harm the baby. ...

https://en.wikipedia.org/wiki/Propylthiouracil

Pancytopenia, aplastic anemia, reversible agranulocytosis, low blood platelets, neutropenia. Chloroquine has not been shown to ... and heart problems such as ventricular fibrillation and low blood pressure. Low blood potassium may also occur. While the usual ... Inside red blood cells, the malarial parasite, which is then in its asexual lifecycle stage, must degrade hemoglobin to acquire ... Intravenous potassium chloride may be required, however this may result in high blood potassium later in the course of the ...

https://en.wikipedia.org/wiki/Chloroquine

Coxon CH, Geer MJ, Senis YA (June 2017). "ITIM receptors: more than just inhibitors of platelet activation". Blood. 129 (26): ... doi:10.1182/blood-2016-12-720185. PMID 28465343. Verbrugge A, Meyaard L (June 2005). "Signaling by ITIM-bearing receptors". ...

https://en.wikipedia.org/wiki/Immunoreceptor_tyrosine-based_inhibitory_motif

CO inhibits blood platelet aggregation and adhesion. CO may play a role as potential therapeutic agent. In mammals, carbon ... It lowers blood pressure and slows hypertensive remodeling of blood vessels, especially thickening of their intima. It also ... Bicarbonate ions are crucial for regulating blood pH. A person's breathing rate influences the level of CO2 in their blood. ... Carbon dioxide is one of the mediators of local autoregulation of blood supply. If its levels are high, the capillaries expand ...

https://en.wikipedia.org/wiki/Gaseous_signaling_molecules

... specifically the platelets in the blood. Platelets are cell fragments in the blood that aid in clotting. Platelets are produced ... Normal platelet counts range from 150,000 to 450,000 platelets per µL of blood. Individuals with XLT usually have drastically ... reduced platelet counts, typically less than 70,000 platelets per µL of blood. Not only are there fewer platelets circulating, ... but individuals with XLT also have smaller platelets. Fewer and smaller platelets causes the efficacy of the clotting mechanism ...

https://en.wikipedia.org/wiki/X_linked_thrombocytopenia

Can have antibodies to blood cells (DAT, anti-neutrophil, anti-platelet). Also, can have positive ANA, RF, ANCA Defective in ... Blood. 116 (14): e35-40. doi:10.1182/blood-2010-04-280347. PMC 2953894. PMID 20538792. Kuehn, H. S.; Caminha, I.; Niemela, J. E ... Blood. 115 (11): 2142-5. doi:10.1182/blood-2009-08-239525. PMID 20068224.[unreliable medical source?] Sneller, Michael C.; Dale ... Blood. 105 (6): 2443-8. doi:10.1182/blood-2004-09-3542. PMID 15542578.[unreliable medical source?] Magerus-Chatinet A, ...

https://en.wikipedia.org/wiki/Autoimmune_lymphoproliferative_syndrome

Monitoring of liver enzymes, platelets, and blood cell counts are recommended. Lamotrigine generally has minimal side effects, ... As a result, kidney function and blood levels of lithium are monitored in patients being treated with lithium. Therapeutic ... blood pressure, and waist circumference. Taking antipsychotics for long periods or at high doses can also cause tardive ... as well as some rare but serious side effects such as blood dyscrasias, pancreatitis, exfoliative dermatitis, and hepatic ...

https://en.wikipedia.org/wiki/Treatment_of_bipolar_disorder

Platelets: inhibit their aggregation and possibly thereby their contribution to blood clotting. Macrophages: inhibit their ... In the model system used to identify them, human platelets pretreated with aspirin to form acetylated COX2 or the statin, ... Eosinophils: inhibit their migration from the blood circulation into inflamed tissues. Monocytes: inhibit their migration ... platelet-activating factor, and PUFA metabolites including in particular leukotrienes (e.g. LTB4), hydroxyeicosatetraenoic ...

https://en.wikipedia.org/wiki/Specialized_pro-resolving_mediators

Another application in laboratories is blood separation. Blood separates into cells and proteins (RBC, WBC, platelets, etc.) ... The blood waste is then removed and another buffer is added and spun inside the centrifuge again. Once the blood waste is ... Haematocrit centrifuges are used to measure the volume percentage of red blood cells in whole blood. Gas centrifuges, including ...

https://en.wikipedia.org/wiki/Centrifuge

... the latter may modify platelet aggregation and blood viscosity. Stroke, particularly intracerebral hemorrhage, is the most ...

https://en.wikipedia.org/wiki/Stroke_in_China

In particular, platelets involved in wound repair and blood homeostasis release ROS to recruit additional platelets to sites of ... August 2002). "NAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment". Blood. 100 (3): 917 ... "Hydrogen peroxide is involved in collagen-induced platelet activation". Blood. 91 (2): 484-90. doi:10.1182/blood.V91.2.484. ... doi:10.1182/blood.V100.3.917. PMID 12130503. Pignatelli P, Pulcinelli FM, Lenti L, Gazzaniga PP, Violi F (January 1998). " ...

https://en.wikipedia.org/wiki/Reactive_oxygen_species

... evidence for aspirin-suppressible platelet activation in vivo". Blood. 80 (8): 1965-71. doi:10.1182/blood.V80.8.1965.1965. PMID ... It may also result in the overproduction of white blood cells and platelets. Most of the health concerns associated with ... Capillaries can become plugged by the very viscous blood, and the flow of blood through the vessels tends to be extremely ... The entire vascular system can become markedly engorged with blood, and circulation times for blood throughout the body can ...

https://en.wikipedia.org/wiki/Polycythemia_vera

Platelets have been separated from whole blood with a DEP-activated cell sorter. Dielectrophoresis can be used to manipulate, ... Strains of bacteria and viruses red and white blood and cells.[citation needed] DEP can also be used to detect apoptosis soon ... This expression has been useful for approximating the dielectrophoretic behavior of particles such as red blood cells (as ... DEP has made it possible to characterize and manipulate biological particles like blood cells, stem cells, neurons, pancreatic ...

https://en.wikipedia.org/wiki/Dielectrophoresis

June 2005). "Quantitative validation of different protein precipitation methods in proteome analysis of blood platelets". ... in the biotechnology industry protein precipitation is used to eliminate contaminants commonly contained in blood. The ...

https://en.wikipedia.org/wiki/Protein_precipitation

Sources of microvesicles include megakaryocytes, blood platelets, monocytes, neutrophils, tumor cells and placenta. Platelets ... unique delivery of CD154 signal by platelet-derived membrane vesicles". Blood. 111 (10): 5028-36. doi:10.1182/blood-2007-06- ... The release of microvesicles has been shown from endothelial cells, vascular smooth muscle cells, platelets, white blood cells ... Activation of platelets via collagen receptor GPVI stimulates the release of microvesicles from platelet cytoplasmic membranes ...

https://en.wikipedia.org/wiki/Microvesicles

... blood products; Class VIIIb - Blood & blood components (whole blood, platelets, plasma, packed red cells, etc.). Class IX - ... Class VIIIa - Medical consumable supplies not including blood & ...

https://en.wikipedia.org/wiki/Classes_of_supply

Individuals with the syndrome have platelet dysfunction. Since platelets are necessary for blood clotting, individuals will ... Blood. 14 (2): 162-9. doi:10.1182/blood.V14.2.162.162. ISSN 0006-4971. PMID 13618373.[permanent dead link] Khalid Al Aboud; ... bleeding problems due to a platelet abnormality (platelet storage pool defect), and storage of an abnormal fat-protein compound ... If platelet aggregation improves with desmopressin, it may be administered in the preoperative period. However, sometimes ...

https://en.wikipedia.org/wiki/Hermansky–Pudlak_syndrome

In addition to whole blood, the drones deliver platelets, fresh frozen plasma, and cryoprecipitate. As of May 2019, more than ... In addition to whole blood, the drones deliver platelets, frozen plasma and cryoprecipitate. During the COVID-19 pandemic in ... In Ghana, the company began using drones in April 2019 to deliver vaccines, blood, and drugs. He was also the CEO and a co- ... Zipline began drone deliveries in Rwanda in late 2016, and primarily delivers blood to urgent medical situations. ...

https://en.wikipedia.org/wiki/Keller_Rinaudo

A small amount of platelets in blood smears compared to the normal range of 150,000 to 450,000 platelets in microliter of blood ... Platelets assist in blood clotting and coagulate when there are damages blood vessels. This coagulation attempts to cease ... Thrombocytopaenia means there is low platelet volume in the blood. This means there are less platelets to coagulate in presence ... platelets can reach the size of an erythrocytes. This large platelet size can be compared with MYH9 disorders where platelet ...

https://en.wikipedia.org/wiki/Epstein_syndrome

Folinic acid protects against the decrease in platelets and white blood cells induced by pyrimethamine. Prednisone may be used ... Seropositivity (positive blood test result) for Toxoplasma is very common and therefore not useful in diagnosis; however, a ... During treatment with pyrimethamine, leukocyte and platelet counts should be monitored weekly. ...

https://en.wikipedia.org/wiki/Toxoplasmic_chorioretinitis

His hematology research included important work on blood coagulation, blood platelets, hemorrhagic diseases, and hemoglobins. ...

https://en.wikipedia.org/wiki/C._Lockard_Conley

Collagen as haemostat: When collagen interacts with platelets it causes a rapid coagulation of blood. This rapid coagulation ... Collagen bases haemostat reduces blood loss in tissues and helps manage bleeding in cellular organs like the liver and spleen. ... In recent studies, silk fibroin has been found to possess antiagulation properties and platelet adhesion. Silk fibroin has been ...

https://en.wikipedia.org/wiki/Biopolymer

Severe side effects may include low blood platelets, low white blood cells, and blood clots. Use during pregnancy may harm the ... Blood. 119 (12): 2764-7. doi:10.1182/blood-2011-08-373514. PMID 22323483. "FDA approves lenalidomide oral capsules (Revlimid) ... "Revlimid faces NICE rejection for use in rare blood cancer Watchdog's draft guidance does not recommend Celgene's drug for NHS ... November 2011). "Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide". Blood. 118 (18 ...

https://en.wikipedia.org/wiki/Lenalidomide

These marrow components can be divided into plasma, red blood cells, platelets, and nucleated cells. The adult stem cell ... Most of these cells are CD34+ heme progenitors (destined to differentiate into blood components), while very few are actually ... Most of the adult bone marrow consists of blood cells in various stages of differentiation. ... platelet lysate and dexamethasone". Am J Case Rep. 9: CR246-51. Centeno CJ, Schultz JR, Cheever M, Robinson B, Freeman M, ...

https://en.wikipedia.org/wiki/Stem_cell_transplantation_for_articular_cartilage_repair

ADP is stored in dense bodies inside blood platelets and is released upon platelet activation. ADP interacts with a family of ... ADP in the blood is converted to adenosine by the action of ecto-ADPases, inhibiting further platelet activation via adenosine ... Under normal conditions, small disk-shape platelets circulate in the blood freely and without interaction with one another. ... ADP receptors found on platelets (P2Y1, P2Y12, and P2X1), which leads to platelet activation. P2Y1 receptors initiate platelet ...

https://en.wikipedia.org/wiki/Adenosine_diphosphate

Healthy myeloid cells produce red blood cells, platelets and white blood cells (apart from lymphocytes). For CML to develop, an ...

https://en.wikipedia.org/wiki/HAP1_cells

April 2007). "Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood". Nature Medicine. 13 ... Hematopoiesis Blood count Haematopoiesis Immune system Innate immune system Trogocytosis White blood cell WebMD (2009). " ... Neutrophils do not return to the blood; they turn into pus cells and die. Mature neutrophils are smaller than monocytes, and ... Once neutrophils have received the appropriate signals, it takes them about thirty minutes to leave the blood and reach the ...

https://en.wikipedia.org/wiki/Granulocyte

"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood". Nature Medicine. 13 (4): 463-9. ... Whereas basophilic white blood cells stain dark blue and eosinophilic white blood cells stain bright red, neutrophils stain a ... of all white blood cells (leukocytes). The stated normal range for human blood counts varies between laboratories, but a ... Blood. 116 (4): 625-7. doi:10.1182/blood-2010-01-259028. PMID 20410504. Wheater PR, Stevens A (2002). Wheater's basic ...

https://en.wikipedia.org/wiki/Neutrophil

Bearer, E. L.; Abraham, M. T. (1999). "2E4 (kaptin): a novel actin-associated protein from human blood platelets found in ... Blood. 99 (12): 4466-4474. doi:10.1182/blood.v99.12.4466. ISSN 0006-4971. PMC 3376088. PMID 12036877. Bearer, E. L.; Chen, A. F ... Li, Zhi; Kim, Eric S.; Bearer, Elaine L. (2002). "Arp2/3 complex is required for actin polymerization during platelet shape ... proteins that regulate actin dynamics in platelets, (Bearer and Abraham, 1999; Bearer et al. Ann. of Hum. Genet, 2000). Recent ...

https://en.wikipedia.org/wiki/Elaine_Bearer

Common adverse effects include low white blood cells, low blood platelets, anemia, swelling, rash, and diarrhea. Severe adverse ... announced that dasatinib may increase the risk of a rare but serious condition in which there is abnormally high blood pressure ...

https://en.wikipedia.org/wiki/Dasatinib

New studies in mice suggest that blood platelets can destroy deadly malaria parasites, but a single dose of aspirin may be ... Platelets are well known for their role in blood clotting and blood vessel repair. Previous studies have shown that platelets ... We believe that s because platelets bind to infected red blood cells and are taken out of circulation because of that, Foote ... New studies in mice suggest that blood platelets can destroy deadly malaria parasites, but a single dose of aspirin may be ...

https://www.webwire.com/ViewPressRel.asp?aId=86586

... caused by low blood platelets. Have any of you ever ... ... Low Blood Platelets By kschmitz, January 25, 2005. in Related ... caused by low blood platelets. Have any of you ever had this diagnosis? Low platelets can be the result of an autoimmune ... Just wondering how the platelets and petechaia turned out -- still there? How low are your platelets? ... Blood? Same. Since that period I have ordered re-tests on all three types of tests, this time from different companies, and ...

https://www.celiac.com/forums/topic/4737-low-blood-platelets/

... a change in diet can help build up blood platelets. An organic diet rich in nutrients can have a beneficial effect on someones ... What Is the Normal Blood Platelet Level?. A: In healthy adults, the normal blood platelet count is 150,000 to 400,000 platelets ... What Are High Blood Platelets a Sign Of?. A: Having too many platelets in the blood is a sign of either thrombocytosis or ... What Is the Easiest Way to Raise Blood Platelets?. A: The easiest way of increasing the level of blood platelets is by eating ...

https://www.reference.com/health/build-up-blood-platelets-642f23556aebe015

Research in the Laboratory for Hemostasis and Platelet Biology, led by Dr. Andrew Johnson, focuses on understanding genetic and ...

https://www.nhlbi.nih.gov/science/hemostasis-and-platelet-biology

2. Comparative counts of platelets in arteries and veins show that arterial blood contains a larger number of platelets than ... It is concluded that new platelets are added to the blood in the capillary areas of the lungs, and that there is a ... THE PRODUCTION OF BLOOD PLATELETS IN THE LUNGS. W. H. Howell, D. D. Donahue ... venous blood. This difference is accentuated under experimental conditions that cause a reduction in the number of platelets. ...

http://jem.rupress.org/content/65/2/177

SEM image of Human blood platelets in the process of clotting. This sample was taken from the root of a tooth from an 18 year ... SEM image of Human blood platelets in the process of clotting. This sample was taken from the root of a tooth from an 18 year ...

https://www.sciencephoto.com/media/711053/view/blood-platelets-sem

Join friendly people sharing true stories in the I A Positive Blood Platelets Required Urgently group. Find forums, advice and ... Do You A Positive Blood Platelets Required Urgently? ... More People Who Positive Blood Platelets Required Urgentlies. * ... has to go thro bone marrow transplantation and he needs A+ blood platelets on urgent basis. Please contact the us on the ...

http://www.experienceproject.com/groups/A-Positive-Blood-Platelets-Required-Urgently/990331

When normal blood is analyzed, platelet deposition is a shear and a time dependent process, reaching maximal levels within 2 ... A new method and device in which whole blood platelet deposition and aggregation on extracellular matrix (ECM) under defined ... A new method for quantitative analysis of whole blood platelet interaction with extracellular matrix under flow conditions.. ... Blood samples of vWD patients showed a very low adhesion and aggregation at high shear rate as reflected by very low surface ...

https://www.ncbi.nlm.nih.gov/pubmed/9062952?dopt=Abstract

List of causes of Cough and Low blood platelet level and Mouth symptoms, alternative diagnoses, rare causes, misdiagnoses, ... Low blood platelet level:*52 causes: Low blood platelet level *Introduction: Low blood platelet level *Low blood platelet level ... Cough AND Low blood platelet level AND Mouth symptoms - Causes of All Symptoms *Cough OR Low blood platelet level OR Mouth ... Cough and Low blood platelet level and Mouth symptoms and Abnormal blood test symptoms (12 causes) ...

http://wrongdiagnosis.com/cosymptoms/cough/low-blood-platelet-level/mouth-symptoms.htm

Clinicians need to be aware of bacterial contamination of blood products, especially platelets. ... In practice, the type of platelet donation (apheresis or whole blood-derived platelets) has dictated the bacterial detection ... Clinician is contacted by the blood collection or transfusion service with information involving a blood or blood component ... Most blood collection centers culture apheresis platelets (derived from single donors), and release the unit after the culture ...

https://www.cdc.gov/bloodsafety/bbp/bacterial-contamination-of-platelets.html

Hospitals and blood banks are adopting new measures to improve the safety of donated platelets-the tiny cells that make blood ... Hospitals and blood banks are adopting new measures to improve the safety of donated platelets-the tiny cells that make blood ... Unlike other blood components such as red cells, which are refrigerated, platelets must be stored at room temperature to remain ... A growing number of studies show that standard tests performed by blood banks before they ship platelets to hospitals miss the ...

https://www.wsj.com/articles/SB10000872396390444226904577559332064269396

Ive had low blood platelets for as long as I can remember.Even before I discovered I was Hep C+. I went thru tx( peg-intron- ... The hepatitis C virus (HCV) is spread by blood-to-blood contact with an infected persons blood. Many people with HCV infection ... or back up of blood flow. THE LARGE SPLEEN sequesters or HIDES platelets....hence the low platelets (thrombocytopenia) 3) The ... Ive had low blood platelets for as long as I can remember.Even before I discovered I was Hep C+. I went thru tx( peg-intron- ...

https://www.dailystrength.org/group/hepatitis-c/discussion/low-blood-platelets

Blood platelets are deceptively simple cells. They circulate in the form of flattened disks, dwarfed by the larger erythrocytes ... The Cytoskeleton of Human Blood Platelets. In: Harris J.R. (eds) Megakaryocytes, Platelets, Macrophages, and Eosinophils. Blood ... White, J. G., and Sauk, J. J., 1984, Microtubule coils in spread blood platelets, Blood 64: 470-478.PubMedGoogle Scholar ... Actin Filament Human Platelet Detergent Extraction Parallel Bundle Human Blood Platelet These keywords were added by machine ...

https://link.springer.com/chapter/10.1007/978-1-4757-9531-8_5

Changes in blood platelets triggered by COVID-19 could contribute to the onset of heart attacks, strokes, and other serious ... Tags: Aspirin, Blood, Blood Clot, Blood Pressure, Diabetes, Gene, Gene Expression, Genetic, Heart, Hematology, High Blood ... Manne, B.K., et al. (2020) Platelet Gene Expression and Function in COVID-19 Patients. Blood. doi.org/10.1182/blood.2020007214. ... Changes in blood platelets triggered by COVID-19 could contribute to the onset of heart attacks, strokes, and other serious ...

https://www.news-medical.net/news/20200630/COVID-19-triggers-changes-in-blood-platelets.aspx

... platelet aggregating factor) in human and animal blood plasma areeffected using a reagent of blood platelets and snake venom ... The reagent andtests may also suitably employ dried blood platelets. The reagentmay comprise dried platelets and either ... in human and animal blood plasma areeffected using a reagent of blood platelets and snake venom havinga positive platelet ... The reagent andtests may also suitably employ dried blood platelets. The reagentmay comprise dried platelets and either ...

https://www.rti.org/publication/fixed-dried-blood-platelets

Blood group alters platelet binding kinetics to von Willebrand factor and consequently platelet function Eimear Dunne, Qin M. ... Blood 2019 :blood-2018-10-881557; doi: https://doi.org/10.1182/blood-2018-10-881557 ... Blood 2019 :blood-2018-11-835371; doi: https://doi.org/10.1182/blood-2018-11-835371 ... Megakaryocytes and platelets from a novel human adipose tissue-derived mesenchymal stem cell line Keiichi Tozawa, Yukako Ono- ...

http://www.bloodjournal.org/collection/platelets-and-thrombopoiesis?sso-checked=true

What causes the increase? What is the danger of too many platelets? -- P.D. ... and my platelet count was 470,000. Three months ago it was 500,000. A week ago it was 650,000. ... Donohue: I had blood work done six months ago, ... TOO MANY PLATELETS CAN LEAD TO BLOOD PROBLEMS. DR. PAUL DONOHUE ... Polycythemia is the blood illness where bone marrow makes too many red and white blood cells and too many platelets. By now, ...

https://www.sun-sentinel.com/news/fl-xpm-1999-06-08-9906070585-story.html

The American Red Cross urges eligible donors to end summer on a positive and potentially lifesaving note with a blood or ... but blood and platelet donors are still needed to help ensure blood products are available to meet hospital patient needs. ... Blood can be safely donated every 56 days and platelets can be given every seven days - up to 24 times a year. To make an ... Red Cross urges eligible donors to close out summer with a blood or platelet donation ...

http://www.redcross.org/news/press-release/Red-Cross-Urges-Blood-or-Platelet-Donation

Platelets are a part of the blood that helps the blood clot. ... shows if you have antibodies against platelets in your blood. ... This blood test shows if you have antibodies against platelets in your blood. Platelets are a part of the blood that helps the ... Abnormal results show that you have anti-platelet antibodies. Anti-platelet antibodies may appear in the blood due to any of ... Platelet antibody - blood. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: ...

https://medlineplus.gov/ency/article/003552.htm

Emerging roles for platelets as immune and inflammatory cells. Blood. 2014;123(18):2759-2767. ... In this issue of Blood, Stefanini et al untangle the specific roles of RAP1A and RAP1B in platelet production, signal ... Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood. 2011;118(14):e101-e111. ... RAPid signaling in platelets. Blood, 132(18), 1864-1865. Accessed November 14, 2018. https://doi.org/10.1182/blood-2018-09- ...

http://www.bloodjournal.org/content/132/18/1864?sso-checked=true

City of Hope strongly supports and values the uniqueness of all individuals and promotes a work environment where diversity is embraced. ...

https://www.cityofhope.org/donate-blood-or-platelets-rdp

BE A HERO THIS VALENTINES DAY Schedule an appointment to donate blood or platelets using the Red Cross Blood Donor App, ... POWER REDS AND PLATELETS NEEDED Eligible donors with types O, A negative and B negative blood are urged to make a Power Red ... Blood and platelet donors are heroes who answer the call to roll up a sleeve and help ensure an adequate supply is available ... Unlike whole blood, which can be safely donated every 56 days, platelets can be donated every seven days, up to 24 times a year ...

https://www.redcross.org/about-us/news-and-events/news/A-Special-Valentine-to-Blood-and-Platelet-Donors.html

Transfusion of whole blood, which contains plasma and all blood cell types including red blood cells and platelets, or packed ... Thrombocytopenia refers to an abnormally low blood-concentration of platelets, which are blood cells that promote blood ... Dogs with blood platelet concentrations of less than 40,000 per microliter of blood are at risk for spontaneous bleeding. ... Low Blood Platelets) in Dogs. Treatment for thrombocytopenia depends on the underlying cause of the low platelet count. ...

https://www.petplace.com/article/dogs/pet-health/thrombocytopenia-low-blood-platelets-in-dogs/

Platelets allow blood to clot, so the main symptoms of low blood platelets include bruising, an inability to stop bleeding from ... Low blood platelets can be a dangerous condition. ... Platelets are cells in the blood that help the blood to clot, ... Low blood platelets can be a dangerous condition. Platelets allow blood to clot, so the main symptoms of low blood platelets ... There are several treatments available for people with low blood platelets. If your low blood platelet count is due to ITP, you ...

http://www.ehow.co.uk/about_5085106_low-blood-platelet-symptoms.html

... the BMC wants blood banks to supply blood and its components such as platelets, plasma, judiciously. ... To avoid adverse effects in patients as a result of excessive and unnecessary blood transfusions, ... The civic body wants blood banks to monitor supply of blood platelets and other components and identify any over-prescription ... the BMC wants blood banks to supply blood and its components such as platelets, plasma, judiciously. mumbai Updated: May 22, ...

https://www.hindustantimes.com/mumbai/mumbai-bmc-wants-blood-banks-to-supply-platelets-judiciously/story-u8GDVIIuODmwSzpRvnYuiK.html

... and platelets. [M -C Shen; C -M Teng; Akikazu Takada;] ... "Blood Platelets"@en ;. schema:name "Blood platelets"@en ;. .. < ... Blood platelets. a schema:Intangible ;. schema:name "Blood platelets"@en ;. .. ... http://experiment.worldcat.org/entity/work/data/369351063#Topic/blood_platelets> # Blood Platelets. a schema:Intangible ;. rdfs ... schema:about blood_platelets> ; # Blood Platelets. schema: ...

http://www.worldcat.org/title/current-aspects-of-blood-coagulation-fibrinolysis-and-platelets/oclc/28224618

In a healthy person, a large number of platelets are manufactured and stored in the body. ... Platelets are the component of blood that helps with clotting. ... Platelets are about a quarter of the size of red blood cells ... Platelets are the component of blood that helps with clotting. If an injury or blood loss occurs, platelets are released, and a ... Regular donors can give platelets every two weeks. Ask us about donating platelets at your next whole blood donation or give us ...

https://www.blood.ca/en/blood/donating-platelets

blood platelet synonyms, blood platelet pronunciation, blood platelet translation, English dictionary definition of blood ... n. any of the minute, nonnucleated cellular elements in mammalian blood essential for coagulation. Noun 1. blood platelet - ... blood platelet. Also found in: Thesaurus, Medical, Encyclopedia. blood platelet. n.. See platelet. ... blood platelet - tiny bits of protoplasm found in vertebrate blood; essential for blood clotting. platelet, thrombocyte ...

https://www.thefreedictionary.com/blood+platelet

The blood platelet in transfusion therapy. [Tibor J Greenwalt; G A Jamieson; American National Red Cross.;] ... Blood platelets--Transfusion a schema:Intangible ;. schema:name "Blood platelets--Transfusion"@en ;. . ... Blood platelets--Transfusion a schema:Intangible ;. schema:name "Blood platelets--Transfusion"@en ;. . ... The blood platelet in transfusion therapy. Author:. Tibor J Greenwalt; G A Jamieson; American National Red Cross.. ...

http://www.worldcat.org/title/blood-platelet-in-transfusion-therapy/oclc/4495656

... Platelet plug formation is a major step in physiological hemostasis, but also in ... Approximately 750 billion platelets circulate in human blood, constantly scanning the vasculature for damage of the endothelial ... followed by platelet activation, adhesion and spreading. During this stepwise processes platelets undergo dramatic shape ... Our main goal is to dissect the molecular and mechanical cues regulating platelet cytoskeleton dynamics and platelet motility ...

http://www.klinikum.uni-muenchen.de/Medizinische-Klinik-und-Poliklinik-I/de/Research/Basic-Research/Research-Areas/Gaertner/index.html

Platelets from all donor types are needed.Platelets have a very limited shelf life of five days and are delivered quickly to ... Patients undergoing bone marrow transplants, surgeries, chemotherapy, radiation or organ transplants often need platelets to ... Platelets are blood cells that help control bleeding. ... Platelets are blood cells that help control bleeding. Patients ... Platelet donors are eligible every two weeks. The collection process is longer than whole blood so you should be prepared to ...

https://www.sandiegobloodbank.org/donors/platelets

... or give blood on board the Dana-Farber Cancer Institute/Brigham and Womens Hospital Blood Mobile, you are making a life-saving ... When you donate blood or platelets at the Kraft Family Blood Donor Center at Dana-Farber Cancer Institute and Brigham and ... All of the blood and platelets collected at the Kraft Center and on the Blood Mobile benefit patients at Dana-Farber and ... When you donate blood or platelets at the Kraft Family Blood Donor Center at Dana-Farber Cancer Institute and Brigham and ...

https://www.dana-farber.org/how-you-can-help/get-involved/donate-blood-and-platelets/

Platelets are really special, because thats what were using for trauma victims, someone who has just got of surgery or cancer ... It turns out the platelet donation process is a bit more time-consuming that the typical blood donation-it can take up to two ... He knows the location well, his donation of a pint of blood platelets brings his total contributions, to date, to nearly 50 ... Donors can specify whether theyre willing to give plasma, red blood cells or platelets. ...

https://www.boiseweekly.com/boise/true-blood-the-critical-need-for-platelets/Content?oid=3799548

Donating blood or platelets is safe and simple, and it can save lives. ... More than 44,000 blood donations are needed every day, according to the American Red Cross. ... How to donate blood or platelets. If youd like to donate blood or platelets, a good first step is to find your local Red Cross ... Why blood and platelet donations are needed. Unlike medicine, blood products cannot be made in a laboratory. But sometimes, ...

https://www.cancer.net/blog/2017-03/help-people-with-cancer-donate-blood-and-platelets

Re: low blood platelet you should for sure ask about itp i also had it when i was younger and low platelet count is the biggest ...

https://www.healthboards.com/boards/4041703-post3.html

Most surprising, LPA-induced platelet aggregation was insensitive to inhibition by aspirin. (uni-muenchen.de)
Platelet-monocyte aggregate formation stimulated by LPA was P-selectin-mediated and insensitive to inhibition by aspirin. (uni-muenchen.de)
E. I. Tucker, U. M. Marzec, M. A. Berny, S. Hurst, S. Bunting, O. J. T. McCarty, A. Gruber, S. R. Hanson, Safety and antithrombotic efficacy of moderate platelet count reduction by thrombopoietin inhibition in primates. (sciencemag.org)

Experimental studies show that a reduction in the number of platelets also inhibits thrombosis, but these treatments also interfere with platelet function. (sciencemag.org)

Only five percent of females and 20 percent of males with normal platelet counts died. (webwire.com)
For example, low platelet counts are often seen in malaria patients in the early stages of infection. (webwire.com)

Blood samples of vWD patients showed a very low adhesion and aggregation at high shear rate as reflected by very low surface coverage (5.2%) and average particle size of single platelets (21.3 microns2). (nih.gov)

When normal blood is analyzed, platelet deposition is a shear and a time dependent process, reaching maximal levels within 2 min at high shear rate (1300 s-1) of about 20% surface coverage and average aggregate size of about 40-50 microns 2. (nih.gov)
Haserück, Nadine (2007): Platelet activation and platelet-monocyte aggregate formation by the atherosclerotic plaque lipid lysophosphatidic acid. (uni-muenchen.de)

Such aggregation is the in vitro counterpart of in-vivo platelet clumping seen in AA oxidopathy and shown in figure 11. (aliscience.org)

These substances also inhibited LPA-induced aggregation of platelet-rich plasma, and aggregation and serotonin secretion of washed platelets. (uni-muenchen.de)

LPA-induced aggregation in blood could be completely blocked by the ADP- scavenging enzyme, apyrase, and antagonists of the platelet ADP-receptors P2Y1 and P2Y12. (uni-muenchen.de)
Thus antagonists of platelet P2Y1 and P2Y12 receptors, especially in donors highly sensitive to LPA, might be useful in preventing LPA-elicited thrombus formation in patients with cardiovascular diseases. (uni-muenchen.de)

When the blood-platelet count drops below its normal range, the condition is called thrombocytopenia. (adamkempfitness.com)

A new method and device in which whole blood platelet deposition and aggregation on extracellular matrix (ECM) under defined shear conditions is quantitatively evaluated was developed. (nih.gov)
A 0.25 mL aliquot of citrated whole blood is placed on ECM and a defined shear rate is applied for 2 min using a cone and plate device. (nih.gov)
GT samples at a high shear rate demonstrated surface coverage similar to normal blood samples (21.7%) but with average particle size of single platelets (21.3 microns2). (nih.gov)

If you do happen to sustain a bodily wound or injury, these platelet cells move towards the site and bind damaged blood vessels and form a blood clot. (adamkempfitness.com)
Professor Karlheinz Peter from the Baker Institiute has done some research showing platelets in your blood - which we target to bust strokes/heart attacks - also clot to tumours. (nine.com.au)

In a scientific study of mice with a blood platelet disorder, those who consumed 32 percent fewer calories had an improved platelet count and a longer lifespan. (reference.com)

Because normal hemostasis requires that the platelet concentration remain within a physiological range in the circulation, we evaluated whether lowering the number of circulating platelets-but only to a value still within the normal range-by inhibiting platelet formation in the bone marrow inhibits acute thrombogenesis in baboons. (sciencemag.org)

New studies in mice suggest that blood platelets can destroy deadly malaria parasites, but a single dose of aspirin may be enough to thwart their killing power. (webwire.com)
This study, published in the February 6, 2009 issue of the journal Science, is the first to demonstrate that platelets can kill parasites in the Petri dish and in mice. (webwire.com)
During those studies, they discovered that platelet-deficient mice were much more likely to die of malaria than mice with normal platelets. (webwire.com)
When these platelet-deficient mice were infected with Plasmodium chabaudi, a rodent version of the malaria parasite, half of the females and all of the males died of malaria. (webwire.com)
To ensure that their original observation was not due to other genetic changes caused by knocking out the Mpl gene, the researchers eliminated platelets by giving the mice aspirin, which inactivates platelets. (webwire.com)

Platelets are well known for their role in blood clotting and blood vessel repair. (webwire.com)

Thrombocytes are small blood components that are produced in the bone marrow, and they play a key role in blood clotting. (adamkempfitness.com)

This can induce platelet shape change, platelet aggregation and platelet-monocyte formation at atherosclerotic sites. (uni-muenchen.de)

These two parameters demonstrated positive correlation with the platelet count and the hematocrit. (nih.gov)

LPA directly induced platelet shape change in blood and platelet-rich plasma (PRP) obtained from all blood donors. (uni-muenchen.de)
Albumin was one of the main inhibiting factors of platelet shape change in plasma. (uni-muenchen.de)
Interestingly LPA, at concentrations slightly above plasma levels, induced platelet shape change and aggregation in blood. (uni-muenchen.de)
LPA at low concentrations, starting slightly above plasma level, was also capable of eliciting platelet-monocyte conjugate formation. (uni-muenchen.de)

Previous studies have shown that platelets are active in the body s innate immune system, which responds rapidly to invading pathogens. (webwire.com)

We reduced the platelet count with an inhibitor against the megakaryocyte-promoting hormone thrombopoietin and then showed that experimental occlusive thrombogenesis on collagen-coated vascular grafts was reduced, without impairment of primary hemostasis. (sciencemag.org)

An organic diet rich in nutrients can have a beneficial effect on someone's platelet count. (reference.com)
The National Heart, Lung, and Blood Institute shows normal ranges for the most common values detected on a blood test, including red blood cell count, whit. (reference.com)
In healthy adults, the normal blood platelet count is 150,000 to 400,000 platelets per microliter of blood, according to MedlinePlus. (reference.com)
Having a low platelet count in the blood is generally a symptom of some type of drastic health change. (adamkempfitness.com)
How to Improve Your Blood Platelet/ Thrombocyte Count? (adamkempfitness.com)
If you want to improve your blood platelet count , you can easily do this by living a more holistic and healthy lifestyle. (adamkempfitness.com)
Along with this, cutting out excessive alcohol and refined sugars will naturally help your body to function better, and improve your blood platelet count as well. (adamkempfitness.com)

The new method is an alternative method to clinically evaluate platelet function under close to physiological conditions. (nih.gov)
The main function of these blood components is to stop the bleeding of damaged blood vessels. (adamkempfitness.com)
These results suggest that suppressing platelet production without interfering with the hemostatic function of platelets may offer a safe alternative to current therapies for prevention of stroke and heart attack triggered by blood clotting. (sciencemag.org)

These results indicate a central role for ADP-mediated P2Y1 and P2Y12 receptor activation in supporting LPA-induced platelet aggregation and show that LPA synergistically with ADP induces platelet aggregation in blood. (uni-muenchen.de)

Research in the Laboratory for Hemostasis and Platelet Biology, led by Dr. Andrew Johnson, focuses on understanding genetic and genomic underpinnings of this individual variability in therapeutically targeted CVD pathways. (nih.gov)
however, they also impair platelet-dependent hemostasis that staunches bleeding from wounds and can therefore produce excessive bleeding. (sciencemag.org)

The innate immune response is particularly important in fighting malaria, which causes symptoms once the parasite has invaded the victim s red blood cells. (webwire.com)
So they conducted similar experiments in a Petri dish in which they added human platelets to red blood cells infected with Plasmodium falciparum, the most deadly human malaria parasite. (webwire.com)
We believe that s because platelets bind to infected red blood cells and are taken out of circulation because of that, Foote said. (webwire.com)
Essentially, platelets are cells in the blood stream that help protect the body against an excessive loss of blood when you sustain an injury. (adamkempfitness.com)
These platelet cells look like plates when they are in their "non-active" state . (adamkempfitness.com)

Anatomy14

Organisms3

Diseases15

Chemicals and Drugs77

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes28

Disciplines and Occupations2

Information Science2

Health Care1

Values of three coagulation screening tests of precolostral calves. (1/11030)

Enhanced myocardial glucose use in patients with a deficiency in long-chain fatty acid transport (CD36 deficiency). (2/11030)

Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. (3/11030)

Changes in haematological parameters and iron metabolism associated with a 1600 kilometre ultramarathon. (4/11030)

The Megakaryocyte/Platelet-specific enhancer of the alpha2beta1 integrin gene: two tandem AP1 sites and the mitogen-activated protein kinase signaling cascade. (5/11030)

Activation of stimulus-specific serine esterases (proteases) in the initiation of platelet secretion. I. Demonstration with organophosphorus inhibitors. (6/11030)

Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPib/actin-binding protein (ABP-280) interaction in maintaining adhesion under high shear. (7/11030)

Activation of G12/G13 results in shape change and Rho/Rho-kinase-mediated myosin light chain phosphorylation in mouse platelets. (8/11030)

Blood Platelets

Platelet Aggregation

Platelet Count

Platelet Adhesiveness

Platelet Membrane Glycoproteins

Platelet Factor 4

Thrombin

Adenosine Diphosphate

Platelet Transfusion

Serotonin

Platelet Glycoprotein GPIIb-IIIa Complex

Platelet Glycoprotein GPIb-IX Complex

Megakaryocytes

beta-Thromboglobulin

Platelet Activation

Blood Platelet Disorders

Thrombocytopenia

Platelet Activating Factor

Platelet Function Tests

Fibrinogen

Prostanoic Acids

P-Selectin

von Willebrand Factor

Adenine Nucleotides

Aspirin

Thrombopoiesis

Collagen

Blood Cell Count

Thromboxane A2

Blood Coagulation

Hemostasis

Antigens, Human Platelet

Thrombosis

Thrombopoietin

Cytoplasmic Granules

Rabbits

Alphaprodine

Thromboxanes

Ergoloid Mesylates

Mopidamol

Blood Preservation

Photinia

Afibrinogenemia

Bleeding Time

Cycloheptanes

Ergotamine

Iprindole

Receptors, Thromboxane

Kinetics

Blood Proteins

Calcium

Epinephrine

Platelet Membrane Glycoprotein IIb

Epoprostenol

Arachidonic Acids

Cell Membrane

Platelet Factor 3

Imipramine

Microscopy, Electron

Organoids

Blood Coagulation Disorders

Cytoskeleton

Adenosine Triphosphate

Platelet Aggregation Inhibitors

Time Factors

Prostaglandins

Calcimycin

Arachidonic Acid

Isonipecotic Acids

Receptors, Thrombopoietin

Edetic Acid

Methysergide

Immunochemistry

Molecular Weight

Receptors, Purinergic P2Y12

Receptors, Prostaglandin

Stilbenes

Antibodies, Monoclonal

Platelet Storage Pool Deficiency

Heparin