A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
An alkylating agent of value against both hematologic malignancies and solid tumors.
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.
Loss of scalp and body hair involving microscopically inflammatory patchy areas.
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
A chronic, malignant T-cell lymphoma of the skin. In the late stages, the LYMPH NODES and viscera are affected.
Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Production of drugs or biologicals which are unlikely to be manufactured by private industry unless special incentives are provided by others.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. MYCOSIS FUNGOIDES; SEZARY SYNDROME; LYMPHOMATOID PAPULOSIS; and PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA are the best characterized of these disorders.
Accidental or deliberate use of a medication or street drug in excess of normal dosage.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
Institutions specializing in the care of cancer patients.
A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Compounds that inhibit the function or proteolytic action of the PROTEASOME.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Inorganic or organic compounds that contain the basic structure RB(OH)2.
Peptides composed of between two and twelve amino acids.
The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components.
Substances that are recognized by the immune system and induce an immune reaction.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989)
Inanimate objects that become enclosed in the body.
Substances elaborated by bacteria that have antigenic activity.
Class I-restricted activation of CD8-POSITIVE LYMPHOCYTES resulting from ANTIGEN PRESENTATION of exogenous ANTIGENS (cross-presentation). This is in contrast to normal activation of these lymphocytes (direct-priming) which results from presentation of endogenous antigens.
A glutathione transferase that catalyzes the conjugation of electrophilic substrates to GLUTATHIONE. This enzyme has been shown to provide cellular protection against redox-mediated damage by FREE RADICALS.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Tumors or cancer of the PROSTATE.
Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
White blood cell counts drop, increasing the risk of infection, and red blood cell and platelet counts may also drop due to ... Mechlorethamine belongs to the group of nitrogen mustard alkylating agents. It has been derivatized into the estrogen analogue ... Chlormethine (INN, BAN), also known as mechlorethamine (USAN, USP), mustine, HN2, and (in post-Soviet states) embikhin (эмбихин ... The adverse effects of mechlorethamine depend on the formulation. When used in chemical warfare, it can cause immunosuppression ...
Blood growth factors are medicines that stimulate the bone marrow to produce more of a certain kind of blood cell. Commonly ... This combination of mechlorethamine, vincristine (Oncovin), procarbazine, and prednisone proved capable of curing almost 70% of ... Blood cell growth factors are sometimes used to prevent this (see Supportive care below). Blood counts are checked frequently ... These drugs are sometimes used with ABVD to prevent neutropenia (low white blood cell count) and anemia related to the ...
Aliphatic mustards were developed first, such as mechlorethamine hydrochloride (mustine hydrochloride) which is still used in ... of sulphur mustard gas after military personnel exposed to it during World War I were observed to have decreased white blood ...
Passive targeting exploits the difference between tumor blood vessels and normal blood vessels. Blood vessels in tumors are " ... Nitrogen mustards include mechlorethamine, cyclophosphamide, melphalan, chlorambucil, ifosfamide and busulfan. Nitrosoureas ... Medications that kill rapidly dividing cells or blood cells can reduce the number of platelets in the blood, which can result ... Carboplatin and busulfan dosing rely upon results from blood tests to calculate the optimal dose for each person. Simple blood ...
The presence of these chemicals in the blood activate 5-HT3 receptors in the chemoreceptor trigger zone, in turn releasing ... Dacarbazine Mechlorethamine MOPP/COPP/BEACOPP Streptozocin VIP Some moderately emetogenic agents and regimens include: ... leading to a detectable increase in blood levels of serotonin (5-HT) and its major metabolite, 5-Hydroxyindoleacetic acid (5- ...
From studies of mustard gas, he developed a drug called mechlorethamine or Mustargen. Its success in clinical trials during the ... to study diseases of the blood-forming organs. He built on his research on anemia and tropical sprue. In 1934 Rhoads and ... "Postirradiation Changes in the Levels of Organic Phosphorus in the Blood of Patients with Leukemia", Cancer Research Immerwahr ...
... mechlorethamine) Styrene Other alkylating agents (e.g. dimethyl sulfate) Ultraviolet radiation from the sun and UV lamps ... Increased risk of breast cancer is associated with persistently elevated blood levels of estrogen. Estrogen appears to ...
May 2005). "WHO-EORTC classification for cutaneous lymphomas". Blood. 105 (10): 3768-85. doi:10.1182/blood-2004-09-3502. hdl: ... Mechlorethamine (Nitrogen Mustard) Phototherapy (Broad & Narrow Band UVB or PUVA) Local and Total Skin Electron Therapy (TSET) ...
Millikan, G. A. (1942). "The oximeter: an instrument for measuring continuously oxygen saturation of arterial blood in man". ... using mechlorethamine. The first practical oximeter is described by Glenn Allan Millikan. August 13 - United States Chief of ...
It has been used to treat excessively high blood pressure that affect arteries in the lungs and heart. In the years of 2014 and ... Valchlor (mechlorethamine): In 2013, Actelion announced that Valchlor could be purchased in the United States. Valchlor is an ... ACTELION LAUNCHES VALCHLOR (MECHLORETHAMINE) GEL 0.016% IN THE US". ENP Newswire. Normans Media Ltd. 19 November 2013. " ...
US FDA approves mechlorethamine, a nitrogen mustard compound, for treatment of cancer 1949 - Oncolytic viruses began human ... the first approved drug to inhibit blood vessel formation by tumours, is licensed 2005 - US FDA approves taxol for chemotherapy ...
... blood cell count - blood chemistry study - blood thinner - blood transfusion - blood-brain barrier - blood-brain barrier ... mechlorethamine - MEDI-507 - medial supraclavicular lymph node - median survival time - mediastinal pleura - mediastinoscopy - ... white blood cell - Whitmore-Jewett staging system - whole cell vaccine - Wilms' tumor - Wobe-Mugos E x-ray - x-ray therapy - ... urea nitrogen-see blood urea nitrogen - ureteroscopy - urine cytology-see urine - urokinase - urologic oncologist-see urology ...
... , sold under the brand name Zyloprim among others, is a medication used to decrease high blood uric acid levels. It ... mechlorethamine Co-administration of the following drugs may make allopurinol less active or decrease its half-life: ...
Increased risk of breast cancer is associated with persistently elevated blood levels of estrogen.[37] Estrogen appears to ... Alkylating antineoplastic agents (e.g. mechlorethamine). *Other alkylating agents (e.g. dimethyl sulfate) ...
The presence of these chemicals in the blood activate 5-HT3 receptors in the chemoreceptor trigger zone, in turn releasing ... It is now widely known that cytotoxic chemotherapeutic agents cause a detectable increase in blood levels of serotonin (5-HT) ... Mechlorethamine. *MOPP/COPP/BEACOPP. *Streptozocin. *VIP. Some moderately emetogenic agents and regimens include:[8] ...
Passive targeting exploits the difference between tumor blood vessels and normal blood vessels. Blood vessels in tumors are " ... Nitrogen mustards include mechlorethamine, cyclophosphamide, melphalan, chlorambucil, ifosfamide and busulfan. Nitrosoureas ... Medications that kill rapidly dividing cells or blood cells can reduce the number of platelets in the blood, which can result ... Drug transporters can pump out drugs from the brain and brain's blood vessel cells into the cerebrospinal fluid and blood ...
Busulfan, Carmustine, Mechlorethamine Intercalating agents. interfere with DNA replication and transcription by wedging ... blood cells.[6] ...
Protection from cytotoxic effects induced by the nitrogen mustard mechlorethamine on human bronchial epithelial cells in vitro ... to the endothelium and the alveolar epithelium results in the creation of an open interface between the lung and the blood, ...
... and blood disorders (including anemia, thrombocytopenia, and leukopenia). It has also been associated with infections, and with ... Nitrogen mustards: Mechlorethamine. *Cyclophosphamide# (Ifosfamide#. *Trofosfamide). *Chlorambucil# (Melphalan. *Prednimustine) ...
Doxorubicin, mechlorethamine, bleomycin, vinblastine, vincristine, etoposide, prednisone Non-Hodgkin lymphoma Thal/Dex ... Ang mga ito ay kinabibilangan ng mga blood test, X-rays, CT scans at endoscopy. ... Mechlorethamine, Oncovin (vincristine), procarbazine, prednisone Hodgkin's lymphoma MVAC methotrexate, vinblastine, adriamycin ...
Learn about the potential side effects of mechlorethamine. Includes common and rare side effects information for consumers and ... blood in urine or stools. *cough or hoarseness. * fever or chills. *lower back or side pain ... Applies to mechlorethamine: intravenous powder for solution. Along with its needed effects, mechlorethamine may cause some ... Applies to mechlorethamine: injectable powder for injection. General. The most commonly reported side effect was hematopoietic ...
Each tube of Valchlor contains 0.016% of mechlorethamine which is equivalent to 0.02% mechlorethamine HCL. ... PubChem] The FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the ... mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in ... Blood Brain Barrier. +. 0.9735. Caco-2 permeable. +. 0.754. P-glycoprotein substrate. Non-substrate. 0.5964. ...
Mechlorethamine. Elotuzumab. Nitrogen Mustard Compounds. Immunologic Factors. Physiological Effects of Drugs. Angiogenesis ... Umbilical Cord Blood-Derived Natural Killer Cells, Elotuzumab, Lenalidomide, and High Dose Melphalan, Followed by Stem Cell ... Duration of infused umbilical cord blood (UCB)-natural killer (NK) cells in new host [ Time Frame: Up to 100 days ]. Will be ... Blood Protein Disorders. Multiple Myeloma. Neoplasms, Plasma Cell. Leukemia, Plasma Cell. Neoplasms by Histologic Type. ...
No blood Involvement • Topical steroids • Topical chemotherapy (ie, mechlorethamine) • Phototherapy • Total skin electron beam ...
Get up-to-date information on Mechlorethamine side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more ... This occurs when mechlorethamine triggers the bodys immune system to attack its own red blood cells causing the red blood ... Mechlorethamine is a type of chemotherapy used to treat lung cancer or certain types of blood, bone marrow, or metastatic ... The following serious side effects have been reported with the mechlorethamine injection:. *thrombosis (blood clot). Tell your ...
Typically, blood will be drawn to check levels of blood cells and to monitor functions of some organ systems, such as the ... Low white blood cell levels - increases the risk of infection. • Low red blood cell levels - increases the risk of anemia and ... Generic Name: Mechlorethamine (me-klore-ETH-eh-meen),Nitrogen Mustard, Mustine, Mechlorethamine Hydrochloride. Trade Name: ... How is mechlorethamine given (administered)? Mechlorethamine may be administered into a vein (intravenous), into the abdomen ( ...
... mechlorethamine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation ... Blood coagulation disorder may occur. Bone marrow depression (leukopenia, thrombocytopenia, anemia)-potential contraindication ... encoded search term (mechlorethamine (Mustargen%2C mechlorethamine hcl)) and mechlorethamine (Mustargen, mechlorethamine hcl) ... mechlorethamine (Rx). Brand and Other Names:Mustargen, mechlorethamine hcl, more...Nitrogen Mustard ...
Cell Type : White Blood Cell / Leukocytes Disease. 1193 Words , 5 Pages. CELL ASSIGNMENT PART C CELL TYPE - WHITE BLOOD CELL/ ... Such as-- • Alkylating agents - busulfan, mechlorethamine etc. • Antimetabolites - methotrexate, 6 mercaptopurine,5 ... They are created by a type of white blood cell called plasma cells. Immunoglobulins, also known as antibodies, recognize ... I can see white blood cells, reticular fibers which are very dark. Sketch of Spleen Slide: Describe the structures you observed ...
Mechlorethamine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Mechlorethamine is also used to treat polycythemia vera (a disease in which too many red blood cells are made in the bone ... Before receiving mechlorethamine,. *tell your doctor and pharmacist if you are allergic to mechlorethamine, any other ... Talk to your doctor about the risks of receiving mechlorethamine.. Mechlorethamine may cause other side effects. Call your ...
Mechlorethamine) chemotherapy side effects, how its given, how it works, precautions and self care tips for treatment of ... There is a slight risk of developing a blood cancer such as leukemia after taking mechlorethamine. Talk to your doctor about ... Periodic blood work to monitor your complete blood count (CBC) as well as the function of other organs (such as your kidneys ... Low blood counts. Your white and red blood cells and platelets may temporarily decrease. This can put you at increased risk for ...
Prior autologous or allogeneic bone marrow/peripheral blood stem cell transplant. *More than two prior regimens for therapy of ... Mechlorethamine. Nitrogen Mustard Compounds. Antineoplastic Agents, Alkylating. Alkylating Agents. Molecular Mechanisms of ... Blood Protein Disorders. Hematologic Diseases. Hemorrhagic Disorders. Lymphoproliferative Disorders. Immunoproliferative ... Willing to provide blood and bone marrow samples for correlative research purposes ...
For patients with elevated venous pressure due to mediastinal tumor compression of major blood vessels, mechlorethamine may be ... Mechlorethamine topical solution:. Dissolve 10 mg of mechlorethamine in 50-60 ml of water.. Mechlorethamine topical ointment:. ... Mechlorethamine is administered via intravenous, intracavitary and topical administration. The active form of mechlorethamine ... no detectable plasma mechlorethamine concentrations were found in blood samples obtained after 1 day and 1 month of topical use ...
The procedure for photopheresis is similar to donating blood, but the blood goes into a special machine rather than a ... mechlorethamine (nitrogen mustard, Mustargen). * carmustine (BiCNU, BCNU). Systemic chemotherapy is used to treat CTCL that is ... After they are treated, the lymphocytes are mixed with the rest of the blood and given back to the person. The procedure takes ... The disease can progress to tumours on the skin and may eventually spread to the lymph nodes, liver, spleen, lungs or blood. In ...
Doctors found that these sailors had low white blood cell counts. So they began using nitrogen mustard, or mechlorethamine ( ... This is a cancer of the lymphatic system involving the white blood cells. Nitrogen mustard is still a cancer treatment used ...
The arteries are thicker and more elastic because of the fast pumping of blood that leaves the heart to other organs to the ... Alkylating agents - busulfan, mechlorethamine etc. • Antimetabolites - methotrexate, 6 mercaptopurine,5 fluorouracil etc. • ... The Anatomy And Physiology Of Blood Vessels Essay. 1138 Words , 5 Pages. Circulation 1. Compare and contrasts the anatomy and ... Bacterial LPS if released into the mammalian blood can bind with specific types of binding proteins called as LPS binding ...
p, ,p,Mechlorethamine can lower the number of white blood cells in the blood temporarily, which increases your childs chances ... p, ,p,Mechlorethamine can lower the number of white blood cells in the blood temporarily, which increases your childs chances ... Mechlorethamine. M. Mechlorethamine. Mechlorethamine. English. Pharmacy. NA. NA. NA. Drugs and Supplements. Caregivers Adult ( ... Mechlorethamine. 180.000000000000. Mechlorethamine. Mechlorethamine. M. English. Pharmacy. NA. NA. NA. Drugs and Supplements. ...
Compounds designed for use in the central nervous system should be able to cross the blood-brain barrier or be suitable for ... Alkylating agents such as mechlorethamine, phenylalanine mustard, chlorambucil, ethylenimines and methyl melamines, and ... However, there have been delivery problems and stability in the blood with deleterious side effects due to cytokine treatments ... and streptozocin are used to treat various cancers and have the ability to readily cross the blood-brain barrier. ...
The impact of drug shortages on children with cancer-the example of mechlorethamine. Get Citation Metzger ML, Billett A, Link ... Pediatr Blood Cancer. 2013;60:1855-1899. An Institute of Medicine report raised serious concerns about the safety and quality ... Watts RG, Parsons K. Pediatr Blood Cancer. 2013;60:1320-1324. A multidisciplinary, pharmacy-associated intervention halved the ... In 2009, a shortage of mechlorethamine (a standard component of chemotherapy regimens for childhood leukemia) forced ...
Periodic blood work to monitor your complete blood count (CBC) as well as the function of other organs (such as your kidneys ... Mustard gas derivatives: Mechlorethamine, Cyclophosphamide, Chlorambucil, Melphalan, and Ifosfamide. *Ethylenimines: Thiotepa ... Low blood counts. Your white and red blood cells and platelets may temporarily decrease, putting you at increased risk for ... The "normal" cells most commonly affected by chemotherapy are the blood cells, the cells in the mouth, stomach and bowel, and ...
Periodic blood work to monitor your complete blood count (CBC) as well as the function of other organs (such as your kidneys ... Mustard gas derivatives: Mechlorethamine, Cyclophosphamide, Chlorambucil, Melphalan, and Ifosfamide. *Ethylenimines: Thiotepa ... Low blood counts. Your white and red blood cells and platelets may temporarily decrease. This can put you at increased risk for ... There is a slight risk of developing a blood cancer such as leukemia years after taking thiotepa. Talk to your doctor about ...
... cancer of the white blood cells, acute lymphoblastic leukemia(cancer of the white blood cells), gastrointestinal stromal tumors ... Mechlorethamine. This medication is an alkylating agent, prescribed for certain types of cancer. ... This medication is an antineoplastic agent, prescribed for blood cancer.. Tryosine Kinase Inhibitor - ICD Code -Y43.3 Axitinib ... Aclarubicin or aclacinomycin A is used to treat acute non lymphocytic leukemia, a cancer of the blood and bone marrow. ...
Mechlorethamine Hydrochloride (Nitrogen Mustard). Mechlorethamine hydrochloride [nitrogen mustard (NM)] is one of the most ... monthly monitoring of complete blood counts is recommended for these patients (10). ... 7. Ramsay DL, Halperin PS, Zeleniuch-Jacquotte A. Topical mechlorethamine therapy for early stage mycosis fungoides. J Am Acad ... The phase 2 trial leading to FDA approval of topical mechlorethamine gel (Valchlor) included 260 stage IA to IIA MF patients ...
Pediatr Blood Cancer 2013; 60: 1574 81. CrossRef MEDLINE 37.. D rffel W, R hl U, L ders H, et al.: Treatment of children and ... Schellong G, Riepenhausen M, Creutzig U, et al.: Low risk of secondary leukemias after chemotherapy without mechlorethamine in ... Pediatr Blood Cancer 2010; 55: 1145 52. CrossRef MEDLINE 24.. D rffel W, Riepenhausen M, Ludwig WD, Schellong G: Langzeitfolgen ... Schellong G, Riepenhausen M, Creutzig U, et al.: Low risk of secondary leukemias after chemotherapy without mechlorethamine in ...
White blood cell counts drop, increasing the risk of infection, and red blood cell and platelet counts may also drop due to ... Mechlorethamine belongs to the group of nitrogen mustard alkylating agents. It has been derivatized into the estrogen analogue ... Chlormethine (INN, BAN), also known as mechlorethamine (USAN, USP), mustine, HN2, and (in post-Soviet states) embikhin (эмбихин ... The adverse effects of mechlorethamine depend on the formulation. When used in chemical warfare, it can cause immunosuppression ...
... substituting 6 mg/m2 mechlorethamine with 650 mg/m2 cyclophosphamide); 5 patients mechlorethamine, vincristine, procarbazine, ... Peripheral blood samples were obtained at the time of initial diagnosis or during follow-up. All but one patient were treated ... DNA Extraction and Amplification. DNA was extracted from peripheral blood leukocytes using DNAzol (Invitrogen, Carlsbad, CA) as ...
MECHLORETHAMINE is a chemotherapy drug. This medicine is used to treat many types of cancer like Hodgkins disease, non- ... Hodgkins lymphoma, mycosis fungoides, and some blood and lung cancers. 9. Adcetris ...
Estrogens combined with smoking further increase your risk for stroke, blood clots, high blood pressure, and heart attacks.If ... mechlorethamine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic ... estramustine may worsen control of blood glucose levels. Monitor your blood glucose levels regularly and inform your doctor of ... NOTES: Do not share this medication with others.Laboratory tests (e.g., blood pressure, liver function tests, calcium levels) ...
Urine and blood compared with open abdominal hysterectomy. Therapeutic uses: Mechlorethamine and other structures that are ... 17 to 170 ml of blood, blood mixed with blood. See also affirming the antecedent, affirming the. In populations with highly ... The effects of the main excitatory neurotransmitter and that dilates blood vessels and nerve damage, further. As it is ...
Blood growth factors are medicines that stimulate the bone marrow to produce more of a certain kind of blood cell. Commonly ... This combination of mechlorethamine, vincristine (Oncovin), procarbazine, and prednisone proved capable of curing almost 70% of ... Blood cell growth factors are sometimes used to prevent this (see Supportive care below). Blood counts are checked frequently ... These drugs are sometimes used with ABVD to prevent neutropenia (low white blood cell count) and anemia related to the ...
  • MOPP (mechlorethamine hydrochloride, vincristine, procarbazine hydrochloride, and prednisone): Patients receive MOPP combination chemotherapy comprising mechlorethamine hydrochloride IV on days 1 and 8, vincristine IV on days 1 and 8, oral procarbazine hydrochloride on days 1-14, and oral prednisone on days 1-14. (knowcancer.com)
  • Procarbazine is used as part of the MOPP (mechlorethamine, Oncovin® [vincristine], procarbazine, prednisone) regimen. (lls.org)
  • Cancer medications, including mechlorethamine and vincristine. (curetinnitusandringingears.org)
  • Antibiotics, including erythromycin, neomycin, polymysxin B and vancomycin, as well as cancer medications, including mechlorethamine and vincristine, and water pills, including bumetanide, furosemide or ethacrynic acid all have the ability to cause or worsen tinnitus. (banishtinnitus.net)
  • ABVD (a chemotherapy regimen consisting of doxorubicin, bleomycin, vinblastine, and dacarbazine) is now more commonly used than MOPP (a regimen consisting of mechlorethamine, vincristine, procarbazine, and prednisone) in patients with Hodgkin lymphoma. (aafp.org)
  • Cancer medications - Such as mechlorethamine and vincristine. (brentwoodhearingcenter.com)
  • Certain cancer medications like vincristine and mechlorethamine cause ringing in your ears. (exclusiveniches.com)
  • Mustargen (mechlorethamine). (drugs.com)
  • Mustargen, mechlorethamine hcl, more. (medscape.com)
  • Mustargen is the trade name for Mechlorethamine. (chemocare.com)
  • Nitrogen Mustard, Mustine, and Mechlorethamine Hydrochloride are other names for Mustargen. (chemocare.com)
  • In some cases, health care professionals may use the trade name Mustargen or other names Nitrogen Mustard, Mustine, and Mechlorethamine Hydrochloride when referring to the generic drug name Mechlorethamine. (chemocare.com)
  • So they began using nitrogen mustard, or mechlorethamine (Mustargen) to treat Hodgkin lymphoma . (cancer.net)
  • Chlormethine (INN, BAN), also known as mechlorethamine (USAN, USP), mustine, HN2, and (in post-Soviet states) embikhin (эмбихин), is a nitrogen mustard sold under the brand name Mustargen among others. (wikipedia.org)
  • MUSTARGEN 1 (Mechlorethamine HCl) should be administered only under the supervision of a physician who is experienced in the use of cancer chemotherapeutic agents. (rxdrugsinfo.com)
  • Each vial of MUSTARGEN contains 10 mg of mechlorethamine hydrochloride triturated with sodium chloride q.s. 100 mg. (rxdrugsinfo.com)
  • This occurs when Mustargen triggers the body's immune system to attack its own red blood cells causing the red blood cells to break down. (rxwiki.com)
  • In cases of lung cancer, mechlorethamine hydrochloride is usually injected directly into the lungs via the pulmonary circulation. (thefreedictionary.com)
  • Aliphatic mustards were developed first, such as mechlorethamine hydrochloride (mustine hydrochloride) which is still used in the clinic today. (wikipedia.org)
  • Mechlorethamine hydrochloride is designated chemically as 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride. (rxdrugsinfo.com)
  • Mechlorethamine hydrochloride can cause fetal harm when administered to a pregnant woman. (rxdrugsinfo.com)
  • Mechlorethamine hydrochloride is used to treat cancer. (upmc.com)
  • Mechlorethamine also known as mustine, nitrogen mustard, and HN2, is the prototype anticancer chemotherapeutic drug. (drugbank.ca)
  • Mechlorethamine belongs to the group of nitrogen mustard alkylating agents. (wikipedia.org)
  • The particular nitrogen mustard chlormethine (mechlorethamine) was first synthesized. (wikipedia.org)
  • nonprotein nitrogen (NPN) the nitrogenous constituents of the blood exclusive of the protein bodies, consisting of the nitrogen of urea, uric acid, creatine, creatinine, amino acids, polypeptides, and an undetermined part known as rest nitrogen. (thefreedictionary.com)
  • The bendamustine molecule is composed of three structural elements: a mechlorethamine (nitrogen mustard) group, a benzimidazole ring, and a butyric acid side chain. (freecme.com)
  • The mechlorethamine (nitrogen mustard) group is similar to other alkylators like cyclophosphamide and chlorambucil. (freecme.com)
  • Nitrogen mustards arose from the derivatization of sulphur mustard gas after military personnel exposed to it during World War I were observed to have decreased white blood cell counts. (wikipedia.org)
  • It focused on mechlorethamine, or nitrogen mustard, a drug that has been in short supply until last month, when more became available. (deseretnews.com)
  • Mechlorethamine falls under the category of Nitrogen mustard alkalyting agents. (gpatindia.com)
  • In 2009, a shortage of mechlorethamine (a standard component of chemotherapy regimens for childhood leukemia) forced oncologists to treat patients with an alternative agent, cyclophosphamide (which was thought to be equally effective). (ahrq.gov)
  • There is a slight risk of developing a blood cancer such as leukemia or myelodysplasia after taking cyclophosphamide. (pdfdrugs.com)
  • Estimated two-year cancer-free survival for patients enrolled in the study fell from 88 to 75 percent after the drug cyclophosphamide was substituted for mechlorethamine for treatment of patients with intermediate- or high-risk Hodgkin lymphoma. (danafarberbostonchildrens.org)
  • When mechlorethamine became unavailable, the protocol was revised to allow the cyclophosphamide substitution. (danafarberbostonchildrens.org)
  • Mechlorethamine is a prescription medication available as an injection and topical (applied to the skin) form. (rxwiki.com)
  • Mechlorethamine injection must be given under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to mechlorethamine, any other medications, or any of the ingredients in mechlorethamine injection. (medlineplus.gov)
  • You should not become pregnant or breast-feed while you are receiving mechlorethamine injection. (medlineplus.gov)
  • When dissolved with 10 mL Sterile Water for Injection or 0.9% Sodium Chloride Injection, the resulting solution has a pH of 3-5 at a concentration of 1 mg mechlorethamine HCl per mL. (rxdrugsinfo.com)
  • Some side effects of mechlorethamine may occur that usually do not need medical attention. (drugs.com)
  • What are the possible side effects of mechlorethamine? (aboutkidshealth.ca)
  • Mechlorethamine is in a class of medications called alkylating agents. (medlineplus.gov)
  • Tell your doctor if your child has ever reacted badly to mechlorethamine or any other medications, foods, preservatives, or colouring agents. (aboutkidshealth.ca)
  • Tinnitus can also develop as a side effect to a number of medications, including treatments for cancer, such as mechlorethamine, diuretics including furosemide and ethacrynic acid, quinine medications used for illnesses like malaria, aspirin, antibiotics, and certain antidepressants. (stabilitypact.org)
  • The recommended dose of mechlorethamine varies according to the response to therapy, the other medications being used, and the body weight of the person receiving it. (canada.com)
  • Historically, some uses of mechlorethamine have included lymphoid malignancies such as Hodgkin's disease, lymphosarcoma, chronic myelocytic leukemia, polycythemia vera, and bronchogenic carcinoma Mechlorethamine is often administered intravenously, but when compounded into a topical formulation it can also be used to treat skin diseases. (wikipedia.org)
  • There is no pill form of mechlorethamine. (chemocare.com)
  • Either the powder form or mixed liquid form of mechlorethamine can be dangerous if it gets in your eyes, mouth, or nose, or on your skin or clothing. (healthbanks.com)
  • Mechlorethamine may be administered into a vein (intravenous), into the abdomen (intraperitoneal), into the lining surrounding the heart (intrapericardial), into the lining surrounding the lungs (intrapleural), or directly onto cancer on the skin and the dose depends on several factors, including the condition being treated, the size of the patient, the particular regimen being used and the overall health of the patient. (unm.edu)
  • Intravenous (IV) mechlorethamine should be used cautiously in patients receiving other myelosuppressive therapy (e.g., radiation therapy). (pdr.net)
  • The FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL) in patients who have received prior skin-directed therapy. (drugbank.ca)
  • The mechlorethamine topical form is used in the treatment of mycosis fungoides-type cutaneous T-cell lymphoma (a type of immune system cancer that begins with skin rashes). (rxwiki.com)
  • If oral mucous membrane exposure occurs with topical mechlorethamine gel use, immediately rinse the area for at least 15 minutes with water and promptly seek medical attention. (pdr.net)
  • There have been studies demonstrating that topical administration of mechlorethamine has efficacy in mycosis fungoides-type cutaneous T cell lymphoma. (wikipedia.org)
  • MECHLORETHAMINE (me klor ETH a meen) topical gel is a chemotherapy drug that is used to treat mycosis fungoides which is a type of skin lymphoma. (yourcareeverywhere.com)
  • Your doctor may not want you to receive mechlorethamine. (medlineplus.gov)
  • You should not receive mechlorethamine if you have any type of infection. (healthbanks.com)
  • You should not receive mechlorethamine if you are allergic to it, or if you have any type of infection. (healthbanks.com)
  • Do not receive mechlorethamine if you are pregnant. (healthbanks.com)
  • This phase II trial studies the side effects and best dose of umbilical cord blood- derived natural killer cells when given together with elotuzumab, lenalidomide, and high dose melphalan before autologous stem cell transplant and to see how well they work in treating patients with multiple myeloma. (clinicaltrials.gov)
  • Patients who received umbilical cord blood receive cyclosporine and mycophenolate mofetil as above (no methotrexate). (knowcancer.com)
  • Mechlorethamine is usually administered only into a vein. (medlineplus.gov)
  • Mechlorethamine comes as powder to be mixed with liquid to be injected intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)
  • Mechlorethamine is a yellow liquid that a nurse will give by needle into your child's vein (intravenously or IV). (aboutkidshealth.ca)
  • If mechlorethamine leaks out of the vein through which it is being given, it can cause severe damage. (aboutkidshealth.ca)
  • Your child's skin may darken along the vein that mechlorethamine is given through. (aboutkidshealth.ca)
  • Local irritation, swelling and blood clots are possible in the vein used for infusion. (upmc.com)
  • Water pills or diuretics are commonly used to treat high blood pressure, heart disease and other kinds of kidney and liver diseases. (brentwoodhearingcenter.com)
  • Mechlorethamine is FDA approved for the treatment of advanced Hodgkin's disease, lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, bronchogenic carcinoma, and metastatic cancer resulting in effusion. (unm.edu)
  • Mechlorethamine is also used to treat polycythemia vera (a disease in which too many red blood cells are made in the bone marrow). (medlineplus.gov)
  • Low blood counts. (chemocare.com)
  • Meaning low point, nadir is the point in time between chemotherapy cycles in which you experience low blood counts. (chemocare.com)
  • Doctors found that these sailors had low white blood cell counts. (cancer.net)
  • White blood cell counts drop, increasing the risk of infection, and red blood cell and platelet counts may also drop due to bone marrow damage. (wikipedia.org)
  • Low blood counts, or myelosuppression, occur about 50% of the time with ABVD. (wikipedia.org)
  • Blood counts are checked frequently while receiving chemotherapy. (wikipedia.org)
  • We'll also do routine blood tests to monitor your blood cell counts. (cancercenter.com)
  • low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. (ahealthyme.com)
  • Cancer and the treatments used for cancer can affect your blood counts. (oncolink.org)
  • These articles detail how your blood counts are affected. (oncolink.org)
  • Cancer itself and the therapies used to treat it can affect your normal blood counts. (oncolink.org)
  • This article explains the various types of blood cells, what their normal levels should be and how your body is affected when these counts become too low. (oncolink.org)
  • Includes a chart to track blood counts. (oncolink.org)
  • therefore, complete blood counts should be monitored. (pharmacologicalsciences.us)
  • Ebselen protects brain, skin, lung and blood cells from mechlorethamine toxicity. (faintpower.cf)
  • The effect of vesicant (blister) agents in the form of mustard gas (sulfur mustard, Bis(2-chloroethyl) sulfide) on bone marrow and white blood cells had been known since the First World War. (wikipedia.org)
  • Mechlorethamine treats certain types of cancers. (rxwiki.com)
  • Mechlorethamine may increase the risk that you will develop other cancers. (medlineplus.gov)
  • Individuals other than the patient should avoid direct skin contact with mechlorethamine gel due to the risks of secondary exposure including dermatitis, mucosal injury, and secondary cancers. (pdr.net)
  • Alemtuzumab is a cancer-treating drug used for treating certain cancers of bone marrow and blood cancers such as chronic lymphocytic leukemia (CLL) and lymphoma. (medindia.net)
  • This medication is a protein-tyrosine kinase inhibitor, prescribed for treating certain type of cancers such as chronic myelogenous leukemia (cancer of the white blood cells, acute lymphoblastic leukemia(cancer of the white blood cells), gastrointestinal stromal tumors (tumors of the gastrointestinal tract and other cancers. (medindia.net)
  • This medicine is used to treat many types of cancer like Hodgkin's disease , non-Hodgkin's lymphoma , mycosis fungoides, and some blood and lung cancers. (goodrx.com)
  • The Mario Lemieux Center for Blood Cancers offers personalized treatments for patients with all types of blood cancer. (upmc.com)
  • Patients will usually have scheduled meetings with their healthcare provider while they are being treated with mechlorethamine. (unm.edu)
  • Blood tests will measure levels of electrolyte and metabolic products, and patients should contact their healthcare provider if they experience symptoms such as nausea and vomiting, shortness of breath, an irregular heartbeat, clouding of urine, lethargy and/or joint discomfort. (unm.edu)
  • What are the common (occur in 30% or more of patients) side effects of treatment with mechlorethamine? (unm.edu)
  • What are the less common (occur in 10% to 29% of patients) side effects of treatment with mechlorethamine? (unm.edu)
  • Patients are at a slightly increased risk of developing a secondary malignancy caused by treatment with mechlorethamine. (unm.edu)
  • Use of IV mechlorethamine is contraindicated in patients who have an infectious disease. (pdr.net)
  • In patients who present with pruritus or erythroderma, the diagnosis of mycosis fungoides is often made possible through the examination of a noncutaneous site (eg, blood, lymph nodes). (medscape.com)
  • Central Line Associated Blood Stream Infections in Pediatric Hematology/Oncology Patients With Different Types of Central Lines. (childrenshospital.org)
  • Ethanol lock therapy is used to reduce the incidence of catheter-related blood stream infections (CRBSI) in pediatric patients receiving parenteral nutrition due to intestinal failure. (ahrq.gov)
  • LLS funds lifesaving blood cancer research around the world, provides free information and support services, and is the voice for all blood cancer patients seeking access to quality, affordable, coordinated care. (lls.org)
  • Querleu described a transverse band across the cervix is firm and easily stained by blood vessels of the newborn than in thorax, head and torso and progressively slower in their sentinel randomized trial, when residents were involved, and the gp should refer if there is either: Looking for: (a) objective evidence that some ed with your healthcare provider first before deciding to treat patients allergic to lignocaine. (bigsurlandtrust.org)
  • For prophylactic use to reduce perioperative blood loss and the need for blood transfusion in patients undergoing cardiopulmonary bypass in the course of coronary artery bypass graft surgery who are at an increased risk for blood loss and blood transfusion. (drugbank.ca)
  • In recent years, many patients and caregivers have had their medical care complicated by drug shortages, primarily of generic injectable drugs like mechlorethamine. (danafarberbostonchildrens.org)
  • Working as the Pediatric Hodgkin Consortium, in 2002 the five institutions involved in this study adopted a seven-drug chemotherapy regimen that included mechlorethamine for the treatment of high-risk pediatric patients. (danafarberbostonchildrens.org)
  • A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. (drugbank.ca)
  • Mechlorethamine is a vesicant. (chemocare.com)
  • Mechlorethamine is a highly toxic medication, especially for women who are pregnant, breastfeeding, or of childbearing age. (wikipedia.org)
  • I. To find the maximum tolerated dose (MTD) of umbilical cord blood (UCB)-derived natural killer (NK) cells. (clinicaltrials.gov)
  • Call your doctor for instructions if you miss a dose of mechlorethamine. (healthbanks.com)
  • Blood institute of life, you might directly with strands of skin treatments are similar analgesic effect of the epithelium became interested in the body is a separate drug on board ships, additional double dose of skin cells including uncorrected refractive error. (carolcohen.org)
  • Immunosuppression has been reported with IV mechlorethamine therapy and bacterial, fungal, or viral infection (e.g., varicella, herpes infection) may occur. (pdr.net)
  • Herpes zoster infection may occur during or be precipitated by mechlorethamine treatment. (pdr.net)
  • Mechlorethamine can lower the number of white blood cells in the blood temporarily, which increases your child's chances of getting an infection. (aboutkidshealth.ca)
  • Your white and red blood cells and platelets may temporarily decrease, putting you at increased risk for infection, anemia and or bleeding. (chemocare.com)
  • Drug shortage-associated increase in catheter-related blood stream infection in children. (ahrq.gov)
  • A neutrophil is a type of white blood cell that acts as a first responder when an infection is starting in the body. (oncolink.org)
  • The study involved more than 200 children and young adults with a blood cancer called Hodgkin lymphoma. (deseretnews.com)
  • The adverse effects of mechlorethamine depend on the formulation. (wikipedia.org)
  • Mechlorethamine is a type of chemotherapy used to treat lung cancer or certain types of blood, bone marrow, or metastatic cancer. (rxwiki.com)
  • Each tube of Valchlor contains 0.016% of mechlorethamine which is equivalent to 0.02% mechlorethamine HCL. (drugbank.ca)
  • This medication is prescribed for blood cancer(Chronic Myeloid Leukemia). (medindia.net)
  • Many people using this medication do not have serious side effects.Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes (e.g., depression ), swelling of hands/ feet , worsening of seizures , signs of worsening diabetes control (e.g., increased thirst and urination).This medication may infrequently cause serious problems such as heart attacks, stroke , and blood clots . (medicinenet.com)
  • Mechlorethamine may also be used for purposes not listed in this medication guide. (healthbanks.com)
  • You may be given medication to prevent nausea or vomiting while you are receiving mechlorethamine. (healthbanks.com)
  • This medication may raise your blood pressure. (kaiserpermanente.org)
  • This medication may rarely cause serious problems such as heart attacks, stroke, and blood clots. (kaiserpermanente.org)
  • Women should not get pregnant while on mechlorethamine. (rxwiki.com)
  • you should know that mechlorethamine may interfere with the normal menstrual cycle (period) in women, may stop sperm production in men, and may cause infertility (difficulty becoming pregnant). (medlineplus.gov)
  • Because pregnant women often have elevated blood pressure, they are easily susceptible to tinnitus. (banishtinnitus.net)
  • In two preliminary studies, women who developed GH were found to have significantly lower dietary calcium intake than did pregnant women with normal blood pressure. (adventisthealthcare.com)
  • Review and diligently follow special handling procedures before and during mechlorethamine handling because of the toxic properties of the drug such as corrosivity, carcinogenicity, mutagenicity, and teratogenicity. (pdr.net)
  • Due to the toxic properties of mechlorethamine (e.g., corrosivity, carcinogenicity, mutagenicity, teratogenicity), special handling procedures should be reviewed prior to handling and followed diligently. (rxdrugsinfo.com)
  • Your child needs to take the medicine called mechlorethamine (say: me-klor-ETH-a-meen). (aboutkidshealth.ca)
  • MECHLORETHAMINE (me klor ETH a meen) is a chemotherapy drug. (ahealthyme.com)
  • Platelets play a major role in blood clotting so thrombocytopenia puts you at a higher risk of bleeding. (oncolink.org)
  • MECHLORETHAMINE is a chemotherapy drug. (goodrx.com)
  • The impact of drug shortages on children with cancer-the example of mechlorethamine. (ahrq.gov)
  • In water or body fluids, mechlorethamine undergoes rapid chemical transformation and combines with water or reactive compounds of cells, so that the drug is no longer present in active form a few minutes after administration. (rxdrugsinfo.com)
  • Leprae is an anti-cancer drug mechlorethamine (a prodrug) changes spontaneously into the peritoneal cavity without separate closure could result in mental activity, restlessness, insomnia, nervousness, tremors, palpitation, ataxia and tremors. (yogachicago.com)
  • Curcumin makes this stay in the blood for a longer time, thereby reducing the need for taking higher amounts of the drug. (biomeric.us)
  • Based on earlier studies, the drug was considered a safe and effective alternative to mechlorethamine. (danafarberbostonchildrens.org)
  • Blood pressure irregularity can increase the likelihood of tinnitus or make existing tinnitus more noticeable. (stabilitypact.org)
  • Some people have blood vessels near their ears that are capable of causing tinnitus. (banishtinnitus.net)
  • Blood vessel disorders are also the cause of tinnitus. (exclusiveniches.com)
  • After treatment with mechlorethamine has ended, normal hair growth should return. (drugs.com)
  • Giving natural killer cells from donor umbilical cord blood before transplant may also kill myeloma cells that remain in the body after the last chemotherapy treatment. (clinicaltrials.gov)
  • After treatment, stem cells are then returned to the patient to replace the blood- forming cells that were destroyed by the chemotherapy. (clinicaltrials.gov)
  • What are the possible late side effects of treatment with mechlorethamine? (unm.edu)
  • Use effective birth control to avoid pregnancy during your treatment with mechlorethamine. (healthbanks.com)
  • 7 hair thinning of sad typically begins with high blood lipid disorders and 10,000 lux light sensitivity, which is verruca vulgaris psoriasis treatment owned by mistake. (carolcohen.org)
  • Ozonides are transmitted across the psoriasis light treatment ireland blood concentration of the surface areas on the cycle. (carolcohen.org)
  • Processes for preparing the modified red blood cells, pharmaceutical and diagnostic compositions containing the same and methods of diagnosis and treatment involving the modified red blood cells are described. (patentsencyclopedia.com)
  • Mechlorethamine, which has been used in cancer treatment since the 1960s, has only recently become available again. (danafarberbostonchildrens.org)
  • Accidental skin contact with parenteral mechlorethamine should be treated with thorough rinsing of the area with water for at least 15 minutes, while removing contaminated clothing and shoes, followed by rinsing with 2% sodium thiosulfate solution. (pdr.net)
  • Mechlorethamine belongs to a group of drugs called alkylating agents. (rxwiki.com)
  • Alkylating agents - busulfan, mechlorethamine etc. (bartleby.com)
  • Mechlorethamine, a biologic alkylating agent, has a cytotoxic action which inhibits rapidly proliferating cells. (rxdrugsinfo.com)
  • Bone morrow function should be recovered prior to administering IV mechlorethamine and/or radiation therapy. (pdr.net)
  • Your white and red blood cells and platelets may temporarily decrease. (chemocare.com)
  • When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. (clinicaltrials.gov)
  • This is a decrease in the number of white blood cells, red blood cells, and platelets. (upmc.com)
  • On longer administration, the level of RBCs, WBCs and blood platelets may decrease, which suppresses the immune system of the patient and the patient will beat higher risk of other diseases. (gpatindia.com)
  • Not everybody is aware that merck & co. is not a producer of mechlorethamine, but just drop a packager. (searchenginerockstar.com)
  • Acetyldigitoxin may decrease the cardiotoxic activities of Mechlorethamine. (drugbank.ca)
  • Acetyldigoxin may decrease the cardiotoxic activities of Mechlorethamine. (drugbank.ca)
  • thrombosis (blood clot). (rxwiki.com)
  • Mechlorethamine can lower blood cells that help your body fight infections and help your blood to clot. (healthbanks.com)
  • A blood clot in your arm may cause your arm to swell, appear red and warm, and/or cause pain. (upmc.com)
  • The lymphoma cells are in the skin, blood and lymph nodes. (cancer.ca)
  • Mycosis fungoides is the most common cutaneous T-cell lymphoma (CTCL), which starts in cells called T-lymphocytes (white blood cells). (bccancer.bc.ca)
  • Sézary syndrome is like mycosis fungoides, but the lymphoma cells are also found in the blood or the lymph nodes. (bccancer.bc.ca)
  • Aclarubicin or aclacinomycin A is used to treat acute non lymphocytic leukemia, a cancer of the blood and bone marrow. (medindia.net)
  • The bone marrow, the tissue inside the bones, produces new red and white blood cells. (encyclopedia.com)
  • Acute myeloid leukaemia is a type of cancer that affects the blood and bone marrow. (tipdisease.com)
  • These cells crowd the bone marrow, preventing it from making normal blood cells. (tipdisease.com)
  • Each sub-type provides information on the type of blood cell involved and the point at which it stopped maturing properly in the bone marrow. (tipdisease.com)
  • Mechlorethamine may harm the fetus. (medlineplus.gov)
  • It is not known whether mechlorethamine passes into breast milk or if it could harm a nursing baby. (healthbanks.com)
  • Though ingestion is uncommon, if mechlorethamine is swallowed it causes severe chemical burns to the gastrointestinal tract and concomitant nausea, vomiting, diarrhea, abdominal pain, and hemorrhage. (wikipedia.org)
  • The disease can progress to tumours on the skin and may eventually spread to the lymph nodes, liver, spleen, lungs or blood. (cancer.ca)
  • What blood in urine or stools are available for motion sickness? (sovawinetrail.com)
  • You should differ not give your child Mechlorethamine to treat the blood in urine or stools associated with the chickenpox. (sovawinetrail.com)