Hyperemia: The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).Regional Blood Flow: The flow of BLOOD through or around an organ or region of the body.Forearm: Part of the arm in humans and primates extending from the ELBOW to the WRIST.Vasodilation: The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Brachial Artery: The continuation of the axillary artery; it branches into the radial and ulnar arteries.Adenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.Laser-Doppler Flowmetry: A method of non-invasive, continuous measurement of MICROCIRCULATION. The technique is based on the values of the DOPPLER EFFECT of low-power laser light scattered randomly by static structures and moving tissue particulates.Blood Flow Velocity: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.Vasodilator Agents: Drugs used to cause dilation of the blood vessels.Microcirculation: The circulation of the BLOOD through the MICROVASCULAR NETWORK.Plethysmography: Recording of change in the size of a part as modified by the circulation in it.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Cerebrovascular Circulation: The circulation of blood through the BLOOD VESSELS of the BRAIN.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Vascular Resistance: The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.Fractional Flow Reserve, Myocardial: The ratio of maximum blood flow to the MYOCARDIUM with CORONARY STENOSIS present, to the maximum equivalent blood flow without stenosis. The measurement is commonly used to verify borderline stenosis of CORONARY ARTERIES.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Nitric Oxide: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.Coronary Vessels: The veins and arteries of the HEART.Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)Constriction: The act of constricting.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Theophylline: A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.Muscle, Skeletal: A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Leg: The inferior part of the lower extremity between the KNEE and the ANKLE.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Skin Temperature: The TEMPERATURE at the outer surface of the body.Ketorolac: A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is an NSAID and is used principally for its analgesic activity. (From Martindale The Extra Pharmacopoeia, 31st ed)Prostaglandins: A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.Nitric Oxide Synthase: An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.Fingers: Four or five slender jointed digits in humans and primates, attached to each HAND.Blood Circulation: The movement of the BLOOD as it is pumped through the CARDIOVASCULAR SYSTEM.Hippocampus: A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.Urethane: Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.Nails: The thin, horny plates that cover the dorsal surfaces of the distal phalanges of the fingers and toes of primates.Arterioles: The smallest divisions of the arteries located between the muscular arteries and the capillaries.Vanillic Acid: A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).Blood-Brain Barrier: Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.Carotid Artery, Common: The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.Gerbillinae: A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Memory: Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.Phosphates: Inorganic salts of phosphoric acid.Muscles: Contractile tissue that produces movement in animals.Vibrissae: Stiff hairs projecting from the face around the nose of most mammals, acting as touch receptors.
Neuropathic arthropathy
Blepharochalasis
List of adverse effects of nilotinib
CiNii 論文 -
Hemodynamics under Hippocampal Functional Hyperemia in Anesthetized Rat : A...
Role of Neuronal Nitric Oxide Synthase in Regulating Retinal Blood Flow During Flicker-Induced Hyperemia in Cats | IOVS | ARVO...
Vanillic acid attenuates cerebral hyperemia, blood-brain barrier disruption and anxiety-like behaviors in rats following...
Functional hyperemia and mechanisms of neurovascular coupling in the retinal vasculature. - PubMed - NCBI
Technetium-99m-ECD SPECT Fails to Show Focal Hyperemia of Acute Herpes Encephalitis
Acute effects of glibenclamide on reactive hyperaemia in the lower limbs in humans.
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive...
Evidence for phosphate as a mediator of functional hyperaemia in skeletal muscles | SpringerLink
Reactive hyperemia | Define Reactive hyperemia at Dictionary.com
Postocclusive Hyperemia Measured with Laser Doppler Flowmetry and Transcutaneous Oxygen Tension in the Diagnosis of Primary...
Effect of Lowering the Glycemic Load With Canola Oil on Glycemic Control and Cardiovascular Risk Factors: A Randomized...
Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2 depletion | PNAS
CDC - The Emergency Response Safety and Health Database: Glossary - NIOSH
Frontiers | Sympathetic limitation of exercise hyperemia: even hypoperfused muscle is not exempted | Physiology
Subendocardial to subepicardial absolute myocardial blood flow at rest and hyperaemia determined by first pass-cmr and fermi...
Active hyperemia | definition of active hyperemia by Medical dictionary
Abstract 19997: Contrasting Regulatory Functions of Coronary Arterial Kvβ Subunits in Metabolic Hyperemia | Circulation
Real-time blood flow visualization using the graphics processing unit
Effect of aspirin and ifetroban on skeletal muscle blood flow in patients with congestive heart failure treated with enalapril ...
Role of Glial Cells in Regulating Retinal Blood Flow During Flicker-Induced Hyperemia in Cats | IOVS | ARVO Journals
Impaired Glucose Tolerance and Reduced Microvascular Hyperaemia | Clinical Science | Portland Press
Effect of Theophylline on Exercise-Induced and Ischaemic Hyperaemia in the Human Forearm | Clinical Science | Portland Press
InduceFlowRestrictNitric oxideReferred to as functional hyperemiaCongestionHumansAdenosine-induced hyperemiaReactive hyperemia indexVenous hyperemiaConjunctivalCapillaryForearmIncreasesDopplerCerebral blooDilationCutaneousVascularRetinalMetabolicHypotensionConclusionsRednessMyocardial blood flowEndothelialArteriesArteriolesTissueCarotidOccursCapillariesPhysiologicalInflammationArteryCereb Blood Flow MetabOxygenationObstructionEdemaPassivePhysiologyTransientPeakNeuronalIschemicSystolic blood prCirculationEngorgementElevated plus
Induce1
- The diagnostic accuracy was independent of vessel, embedded versus core laboratory-generated ECG gating signal, use of intravenous versus intracoronary adenosine to induce hyperemia, and clinical site. (itags.org)
Flow1
- We tested the hypothesis that the attenuated cerebral blood flow (CBF) response to whisker stimulation seen after NO synthase (NOS) inhibition requires 20-HETE synthesis and that the ability of an epoxyeicosatrienoic acids (EETs) antagonist to reduce the CBF response is blunted after NOS inhibition but restored with simultaneous blockade of 20-HETE synthesis. (elsevier.com)
Restrict1
- These results indicate that 20-HETE synthesis normally does not substantially restrict functional hyperemia. (elsevier.com)
Nitric oxide10
- 7 also reported that intravenous injection of the nonselective nitric oxide synthase (NOS) inhibitor Nω-Nitro-L-arginine methyl ester (L-NAME) prevents a flicker-induced increase in RBF measured using microsphere methods, suggesting that nitric oxide (NO) may play a role in flicker-induced retinal hyperemia. (arvojournals.org)
- Some of the putative vasodilatory agents (associated with metabolism) include, but are not limited to: Carbon dioxide (CO2), hydrogen ion (H+), potassium (K+), adenosine (ADO), nitric oxide (NO)). These vasodilators released from the tissue act on local arterioles causing vasodilation, this causes a decrease in vascular resistance and allows an increase in blood flow to be directed toward the capillary bed of the active tissue. (wikipedia.org)
- 1 Studies in humans have shown that endothelium-derived nitric oxide also contributes to reactive hyperemia. (ahajournals.org)
- Smaller scale mechanistic studies suggest that the nitric oxide-dependent component of reactive hyperemia may be particularly affected by risk factors. (ahajournals.org)
- The NITRAFLEX™ pre-training formula contains ingredients that in vitro, animal and clinical studies suggest possess properties that may help advanced athletes maximize energy, intensity, vascularity and reactive hyperemia (pumps) during their workouts, and provide long-term support of testosterone and nitric oxide levels in the healthy range when used as directed. (gnc.com)
- We think, looking at our results, that the reduction in oxidative stress and the increase in the nitric oxide bioavailability are behind the observed improvement in ischemic reactive hyperemia," Dr. Pérez Jiménez said. (bio-medicine.org)
- To further investigate the mechanisms, postischemic skin hyperemia was measured before and after intradermal injection of the nitric oxide synthase inhibitor L-NAME and its inactive isoform D-NAME (0.5 micromol/10 microl each). (uzh.ch)
- Capsaicin-induced hyperemia was blocked by Zangrado, which also attenuated the production of nitric oxide by activated macrophages. (biomedcentral.com)
- In contrast, basal vessel diameter and dilatation after prolonged episodes of reactive hyperemia, hand warming, and distal infusion of acetylcholine were not attenuated by nitric oxide synthesis inhibition. (ahajournals.org)
- Dilatation after brief episodes of hyperemia is mediated by release of nitric oxide, whereas dilatation during sustained hyperemia is unaffected by NO synthesis inhibition. (ahajournals.org)
Referred to as functional hyperemia2
- Background -Cerebral blood flow is tightly coupled to neuronal metabolic activity, a phenomenon referred to as functional hyperemia. (ahajournals.org)
- To maintain neuronal function, the brain has evolved neurovascular coupling mechanisms to increase the regional blood flow, which Roy and Sherrington 1 referred to as functional hyperemia, when they first described this concept more than a century ago. (arvojournals.org)
Congestion5
- If the heart can't pump blood out through the body, it can build up and cause congestion in other organs like the liver , kidneys, and spleen, and lungs . (medicinenet.com)
- leptomeningeal hyperemia congestion of the pia-arachnoid. (thefreedictionary.com)
- Hyperemia and Congestion results from what process? (studystack.com)
- Edema Hyperemia and Congestion Hemorrhage Hemostasis and Thrombosis Embolism Infarction Shock. (slideserve.com)
- As blood flow out of the heart slows, blood returning to the heart through the veins backs up, causing congestion in the tissues. (thefreedictionary.com)
Humans9
- Acute effects of glibenclamide on reactive hyperaemia in the lower limbs in humans. (biomedsearch.com)
- Three episodes of 1 min ischemia in the lower limbs in humans reduced the metabolic debt repayment (expressed as AUC of reactive hyperaemia) following more prolonged ischemia (666.6+/-86.6 vs 500.0+/-33.5 ml/100 ml). (biomedsearch.com)
- For this purpose they developed an elegant model of forearm blood flow limitation in humans by use of an inflatable balloon positioned in the brachial artery. (frontiersin.org)
- The current study aimed at showing how oral nitrate conversion by bacteria is linked to blood pressure regulation in humans. (news-medical.net)
- General anesthesia with sevoflurane decreases myocardial blood volume and hyperemic blood flow in healthy humans. (biomedsearch.com)
- To examine the role of limb posture on vascular conductance during rapid changes in vascular transmural pressure, we determined brachial (n = 10) and femoral (n = 10) artery post-occlusive reactive hyperemic blood flow (RHBF, ultrasound/Doppler) and vascular conductance in healthy humans with. (ebscohost.com)
- 11 In humans, dilatation of conduit arteries in response to reactive hyperemia is reduced by inhibitors of NO synthesis, suggesting an important role for NO in FMD. (ahajournals.org)
- In animals 14 and humans, 15 coronary FMD in response to sustained hyperemia induced by distal infusion of adenosine seems resistant to the effects of inhibition of NO synthesis. (ahajournals.org)
- In this study, we examined the relationship between conduit artery blood flow and dilatation to determine how the dynamic characteristics of the flow stimulus influence the mechanisms of conduit artery dilatation in healthy humans and patients at risk for atherosclerosis. (ahajournals.org)
Adenosine-induced hyperemia2
- Myocardial blood flow at rest and during adenosine-induced hyperemia was quantified by contrast-enhanced magnetic resonance imaging, to study the relation between regional flow and function after multivariable adjustment for age, gender, body mass index, left ventricular mass, and traditional risk factors. (ahajournals.org)
- Using myocardial contrast echocardiography, myocardial blood flow (MBF) and microcirculatory variables were assessed at rest, during adenosine-induced hyperemia, and after cold pressor test-induced sympathetic stimulation. (biomedsearch.com)
Reactive hyperemia index1
- Secondary outcomes included calculated Framingham CVD risk score and reactive hyperemia index (RHI) ratio. (diabetesjournals.org)
Venous hyperemia2
- venous hyperemia passive hyperemia . (thefreedictionary.com)
- Reactive hyperaemia or venous hyperemia is the transient increase in organ blood flow that occurs following a brief period of ischaemia. (wikipedia.org)
Conjunctival3
- Type II diabetes is associated with conjunctival hypoxia , increased average blood vessel diameter, and capillary loss. (wikipedia.org)
- Carotid artery occlusion is associated with slower conjunctival blood flow and apparent capillary loss. (wikipedia.org)
- She had a diffuse erythematous macular rash and bilateral nonpurulent conjunctival hyperemia without meningeal signs. (cdc.gov)
Capillary4
- Folkow, B., Halicka, H. D.: A comparison between 'red' and 'white' muscle with respect to blood supply, capillary surface area and oxygen uptake during rest and exercise. (springer.com)
- We demonstrate that the plasma membrane phospholipid, PIP 2 , is fundamental to sustaining the activity of inwardly rectifying potassium channels-the molecular feature that allows capillary endothelial cells to sense ongoing neuronal activity and trigger an increase in local blood flow. (pnas.org)
- Notable in this context, we recently reported that increases in extracellular K + concentration ([K + ] o ), such as those evoked by neuronal activity, trigger an ascending hyperpolarizing signal that dilates upstream arterioles and enhances capillary red blood cell (RBC) flux and cerebral blood flow ( 3 ). (pnas.org)
- Sickle-cell anemia is associated with blood vessel sludging, altered blood flow and blood vessel diameter, and capillary micro-haemorrhages . (wikipedia.org)
Forearm6
- We will explore whether the post-occlusive reactive hyperemia in the forearm is potentiated, because during ischaemia, more adenosine is formed in these subjects. (bioportfolio.com)
- The results demonstrate that the incomplete restoration of blood flow was indeed the result of a sympathetic vasoconstrictor influence in the forearm microcirculation, as the non-selective α-adrenoceptor antagonist phentolamine facilitated blood flow recovery to pre-inflation levels. (frontiersin.org)
- Forearm blood flow (ml/min/100 ml) at rest and during rhythmic handgrip exercise and after transient arterial occlusion was determined by strain gauge plethysmography before and 4 h and six weeks after combined administration of enalapril with either aspirin, ifetroban or placebo in a multicenter, double-blind, randomized trial of 62 patients with mild to moderate heart failure. (onlinejacc.org)
- Before randomization, forearm hemodynamics were similar in the three treatment groups except for increased resting forearm blood flow and decreased resting forearm vascular resistance in the aspirin group when compared with the placebo group. (onlinejacc.org)
- After combined administration of enalapril and study drug for 4 h and six weeks, changes from prerandomization values of mean arterial pressure, forearm blood flow and forearm vascular resistance at rest, during handgrip exercise and after transient arterial occlusion did not differ among the three treatment groups. (onlinejacc.org)
- Analysis of the blood flow velocity in the forearm was made in comparison to established methods of estimating endothelial function, clinical markers of cardiovascular risk, the Framingham risk score and global atherosclerosis determined by whole body magnetic resonance angiography. (diva-portal.org)
Increases8
- However, the investigators also observed that intravenous injection of L-NAME caused increases in the mean arterial systemic blood pressure (BP) from 110 to 146 mm Hg. (arvojournals.org)
- Photic stimulation dilates retinal arterioles producing blood flow increases, a response termed functional hyperemia. (nih.gov)
- When the body temperature increases, extra blood flows to the skin to help the body release excess heat. (medicinenet.com)
- this process, termed neurovascular coupling, underlies use-dependent increases in local perfusion (functional hyperemia). (pnas.org)
- This drug significantly reduced the incidence of VF protecting seven of eight animals ( p = 0.0007) without altering plasma insulin, blood glucose, or the increases in mean coronary blood flow induced by either exercise or 15-s coronary occlusions. (aspetjournals.org)
- Reactive hypermia" describes the increase in muscle blood flow that occurs during high-intensity resistance exercise and produces the "pump" associated with increases in muscle size. (fredmeyer.com)
- Reactive hyperemia: This happens when blood flow increases after a temporary interruption. (medicalnewstoday.com)
- Cellular O2 supply and mitochondrial oxidation state are restored early during reactive hyperemia by increased O2 delivery, increases in tissue blood volume and enhanced O2 extraction. (spie.org)
Doppler11
- Using laser Doppler velocimetry, we measured the vessel diameter and blood velocity simultaneously and calculated the retinal blood flow (RBF) in feline first-order retinal arterioles. (arvojournals.org)
- B ) Blood flow increase to flicker stimulation (black bar) measured at the rim of the optic disc in cats with laser Doppler flowmetry. (nih.gov)
- Öberg, "Evaluation of a laser doppler flowmeter foi measurement of tissue blood flow," IEEE Transactions on Biomedical Engineering , vol. 27, no. 10, pp. 597-604, 1980. (hindawi.com)
- A laser Doppler flowmeter was used to assess blood flow changes in habitual smokers, as compared with nonsmokers, where members of both groups were young and healthy. (nih.gov)
- Over the next four hours, blood samples were taken and the researchers used Doppler laser to measure endothelial responses to sudden changes in blood flow, which were produced by inflating and then deflating a blood pressure cuff. (bio-medicine.org)
- METHODS: Skin perfusion, measured by laser Doppler flowmetry, was assessed at rest and during reactive hyperemia. (uzh.ch)
- CONCLUSIONS: Reactive hyperemia of the skin microcirculation can be easily and reproducibly assessed by laser Doppler flowmetry. (uzh.ch)
- Arterial pressure, heart rate, cardiac output determined by transthoracic impedance, transcutaneous oxygen (tcPO 2 ) and carbon dioxide (tcPCO 2 ) pressures, and microcirculatory blood flow determined by laser Doppler flowmetry at rest and during a reactive hyperaemia challenge were measured before sedation (NS period), one hour after midazolam infusion (H period), and one hour after midazolam-sufentanil infusion (HS period). (springer.com)
- A transmediastinal artery persists in ≤50% of patients and will appear as a prominent hypoechoic band within the testicle, with blood flow in the opposite direction of the recurrent rami arteries with Doppler imaging. (appliedradiology.com)
- Topical Zangrado (1%) was assessed for anti-pruretic actions in the 5-HT-induced scratching model in rats and evaluated in capsaicin-induced gastric hyperemia as measured by laser doppler flow. (biomedcentral.com)
- Plasmodium falciparum parasitaemia in the first half of pregnancy, uterine and umbilical artery blood flow, and foetal growth: a longitudinal Doppler ultrasound study. (ebscohost.com)
Cerebral bloo7
- We further show that chemical factors released in the brain, including those associated with neuronal activity, cause changes in the levels of PIP 2 , thereby altering endothelial potassium channel signaling and controlling cerebral blood flow. (pnas.org)
- Brain capillaries play a critical role in sensing neural activity and translating it into dynamic changes in cerebral blood flow to serve the metabolic needs of the brain. (pnas.org)
- Endothelial PIP 2 levels would therefore shape the extent of retrograde signaling and modulate cerebral blood flow. (pnas.org)
- Transient MCAO was induced during either isoflurane or ketamine/xylazine (ket/xyl) anesthesia with simultaneously measurement of cerebral blood flow (CBF) in 60 male Wistar rats (380-420 g). (springer.com)
- Study of changes in cerebral blood flow and cerebrovascular reactivity at the period of late postnatal ontogenesis. (ebscohost.com)
- The article reports on the study of modifications in cerebral blood flow and cerebrovascular responsiveness during late postnatal ontogenesis. (ebscohost.com)
- Functional neuroimaging, such as fMRI, is based on coupling neuronal activity and accompanying changes in cerebral blood flow (CBF) and metabolism. (pnas.org)
Dilation5
- The resulting membrane hyperpolarization inhibits voltage-gated Ca 2+ channels and leads to arteriolar dilation, thereby increasing regional nutritive blood flow in response to neuronal activity. (ahajournals.org)
- The relaxation of this smooth muscle results in vascular dilation and increased blood flow. (wikipedia.org)
- 8 Recent evidence from an animal experiment indicates that glial cells play a principal role in coupling neuronal activity to vessel dilation in retinal functional hyperemia. (arvojournals.org)
- Furthermore, flow-mediated dilation and reactive hyperemia incrementally relate to cardiovascular risk, although impaired flow-mediated dilation was the stronger predictor in this population. (ahajournals.org)
- Because reactive hyperemia is the stimulus for flow-mediated dilation and has been suggested to explain in large part the relationship between flow-mediated dilation and cardiovascular disease, 4,7 we examined the relative predictive value of both of these measures of vascular function for cardiovascular events. (ahajournals.org)
Cutaneous1
- Acute and chronic effects of cigarette smoking were measured by using the cutaneous postischemic reactive hyperemia test. (nih.gov)
Vascular4
- Stasis: Blood stasis promotes greater contact between platelets/coagulative factors with vascular endothelium. (wikipedia.org)
- this could be one mechanism underlying age-related alterations in muscle blood flow and vascular control during exercise ( 36 ). (physiology.org)
- The predictive value of reactive hyperemia for cardiovascular events in patients with atherosclerosis and the relative importance of reactive hyperemia compared with other measures of vascular function have not been previously studied. (ahajournals.org)
- Hyperemia, vascular ectasia, or subconjunctival hemorrhage therefore stand out. (aerzteblatt.de)
Retinal3
- Functional hyperemia and mechanisms of neurovascular coupling in the retinal vasculature. (nih.gov)
- In this review, the retinal functional hyperemia response is described, and the cellular mechanisms that may mediate the response are assessed. (nih.gov)
- Finally, outstanding questions concerning retinal blood flow in health and disease are discussed. (nih.gov)
Metabolic5
- Numerous studies over the past decade have implicated modulation of ion channels by several diverse stimuli as one of the principal transduction processes responsible for defining the activation state of cerebral arteriolar muscle and thereby adjusting blood flow to meet metabolic demand. (ahajournals.org)
- n = 4 per group) animals, suggesting a dichotomous regulatory role for each of these subunits in coronary metabolic hyperemia. (ahajournals.org)
- In conclusion, findings suggest that KV1.5 in CVSM associates with KVβ1.1 and KVβ2 subunits, which differentially modulate channel function to fine tune metabolic hyperemia. (ahajournals.org)
- Consequently allowing blood flow to meet and match the metabolic demand of the tissue and prevents a mismatch between O2-demand O2-supply. (wikipedia.org)
- 6) The brain has numerous physiological mechanisms to maintain blood flow to meet metabolic demand, without jeopardising the delicate balance of factors that maintain ICP. (thefreelibrary.com)
Hypotension1
- The drop in blood pressure following acute exercise, called post-exercise hypotension (PEH), is seen in both healthy people and hypertensives, and persists for a few hours. (news-medical.net)
Conclusions2
- Conclusions- Thus, lower reactive hyperemia is associated with increased cardiovascular risk in patients with peripheral arterial disease. (ahajournals.org)
- CONCLUSIONS: In otherwise healthy subjects who are not subjected to surgical stimulation, MBF at rest and after sympathetic stimulation is preserved during sevoflurane anesthesia despite a decrease in myocardial blood volume. (biomedsearch.com)
Redness1
- Hyperemia was graded using a 5-point scale in which 0=no redness and +3=deep, diffuse redness. (clinicaltrials.gov)
Myocardial blood flow2
- 2-4 Close relations between reduced myocardial blood flow (MBF) and regional wall motion abnormalities have been demonstrated in patients with coronary artery disease by contrast ventriculography, 5 nuclear imaging, 6 echocardiography, 7 and magnetic resonance imaging (MRI) 8,9 at rest and during stress induced by exercise and pharmacological stimulation. (ahajournals.org)
- Relative myocardial blood volume (rBV), exchange flow velocity (β), myocardial blood flow (MBF), MBF reserve (MFR) and endocardial-to-subepicardial (endo-to-epi) MBF ratio were measured from the steady state and contrast replenishment time-intensity curves. (bmj.com)
Endothelial5
- Statins enhance postischemic hyperemia in the skin circulation of hypercholesterolemic patients: a monitoring test of endothelial dysfunction for clinical practice? (uzh.ch)
- Serum creatinine and potassium[K+] were measured monthly, AIC levels every 3 months and CIMT by ultrasound and endothelial function by post hyperemia and nitroglycerine (NTG) - induced peripheral artery tonometry (PAT) via finger plethysmography every six months. (clinicaltrials.gov)
- Using high-resolution ultrasound, we examined the role of endothelial mediators in radial artery dilatation in response to transient (short period of reactive hyperemia) and sustained (prolonged period of reactive hyperemia, hand warming, or an incremental infusion of acetylcholine into the distal radial artery) hyperemia. (ahajournals.org)
- These data suggest heterogeneity of endothelial responses to blood flow that are dependent on the characteristics of the flow stimulus. (ahajournals.org)
- These data suggest heterogeneity of the endothelial response to blood flow, whereby the physical characteristics of the flow stimulus might be important in determining the mechanism of the subsequent dilatation. (ahajournals.org)
Arteries5
- In the present study we aimed to investigate the probable effects of Vanillic acid (VA) on some physiological parameters including cerebral hyperemia, blood-brain barrier (BBB) disruption, anxiety behaviors and neurological deficits induced by bilateral occlusion of the common carotid arteries and reperfusion (BCCAO/R) in rats. (springermedizin.de)
- Poor circulation in the lower extremities occurs when plaque builds up in the arteries that supply blood to the legs. (buzzle.com)
- 2 The paired testicular arteries, arising from the abdominal aorta, are the main blood supply to the testes. (appliedradiology.com)
- The remaining portions of the scrotum receive arterial blood from the pudendal arteries, which arise from the internal iliac artery. (appliedradiology.com)
- Conduit arteries dilate in response to an increase in blood flow. (ahajournals.org)
Arterioles1
- active hyperemia ( arterial hyperemia ) that due to local or general relaxation of arterioles. (thefreedictionary.com)
Tissue10
- In contrast, in the presence of a flow-limiting artery stenosis the sympathetic vasoconstrictor influence may interfere with autoregulation of muscle blood flow, thereby aggravating tissue hypoperfusion. (frontiersin.org)
- Recent research has suggested that the locally produced vasodilators may be acting in a redundant manner, in which the antagonism of one dilator, be it pharmacologically or pathologically, may be compensated for by another in order to preserve blood flow to tissue. (wikipedia.org)
- Conversely, when a tissue is less metabolically active, it produces fewer metabolites which are simply washed away in blood flow. (wikipedia.org)
- Reactive hyperaemia often occurs as a consequence of Raynaud's phenomenon, where the vasospasm in the vasculature leads to ischaemia and necrosis of tissue and thus a subsequent increase in blood flow to remove the waste products and clear up cell debris. (wikipedia.org)
- Reactive hyperemia tests showed increased tissue oxygenation was increased after exercise with placebo use but not after the mouthwash. (news-medical.net)
- MBF was calculated from the relative myocardial blood volume multiplied by its exchange frequency (β) divided by myocardial tissue density (ρT), which was set at 1.05 g·mL(-1). (biomedsearch.com)
- Brain tissue, blood volume and CSF are the three main elements contributing to the generation of ICP. (thefreelibrary.com)
- The volume of brain tissue in a healthy adult is constant, while volumes of blood and CSF within the cranial cavity are tightly controlled to prevent fluctuations in ICP. (thefreelibrary.com)
- In each case, increasing levels leads to increased blood flow in the local tissue. (washington.edu)
- The distance that oxygen can diffuse from blood into oxygen-consuming tissue is limited. (frontiersin.org)
Carotid2
- The blood supply to the palpebral conjunctiva (the eyelid) is derived from the external carotid artery . (wikipedia.org)
- Carotid artery stent placement improves blood flow in the affected hemisphere in symptomatic and asymptomatic patients. (ajnr.org)
Occurs5
- To address this, we monitored these parameters simultaneously under NMDA-infusion via microdialysis in the hippocampus of urethane-anesthetized rats and found a greater elevation in RBC-V than in RBC-C. This suggests that an RBC-V-dependent increase in RBC-F occurs under NMDA-induced functional hyperemia in the hippocampus as well as in the cortex. (nii.ac.jp)
- There are a number of different reasons why hyperemia occurs. (medicinenet.com)
- When an injury or infection occurs, the body sends blood to the area to repair the wound and fight off infection. (medicinenet.com)
- Active hyperemia is often a natural response that occurs as the body responds to activity. (medicinenet.com)
- An enzyme that occurs especially in some nerve endings and in the blood and promotes the breakdown of acetylcholine. (cdc.gov)
Capillaries3
- hyperemia resulting from an increased afflux of arterial blood into dilated capillaries. (thefreedictionary.com)
- Hyperemia due to an increased afflux of arterial blood into dilated capillaries. (thefreedictionary.com)
- However, whether and how pericytes are involved in the regulation of blood flow in brain capillaries is still debated. (pnas.org)
Physiological2
- Instead, most of the blood flow serves specific physiological functions in the organs. (washington.edu)
- Now let us see how the above factors control the distribution of blood flow in physiological situations. (washington.edu)
Inflammation1
- Denes A, Ferenczi S, Kovacs KJ (2011) Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size. (springer.com)
Artery4
- Blocking or restricting an artery or vein will cause an increase in blood flow to that area. (medicinenet.com)
- Blocking or restricting an artery or vein can cause hyperemia. (medicinenet.com)
- Blood to the bulbar conjunctiva is primarily derived from the ophthalmic artery. (wikipedia.org)
- The objective of this analysis was to examine the effect of malaria parasitaemia prior to 20 weeks' gestation on subsequent changes in uterine and umbilical artery blood flow and intrauterine. (ebscohost.com)
Cereb Blood Flow Metab1
- J Cereb Blood Flow Metab. (nih.gov)
Oxygenation1
- Thus, myocardial oxygenation is highly regulated during reactive hyperemia. (spie.org)
Obstruction3
- passive hyperemia that due to obstruction of flow of blood from the area. (thefreedictionary.com)
- Diseases involving obstruction or hindrance to the flow of blood in any part of the body can have grave consequences. (buzzle.com)
- especially, used of blood due to either increased influx or to an obstruction to outflow. (thefreedictionary.com)
Edema1
- Umbilical edema and hyperemia. (iahf.com)
Passive1
- Passive hyperemia is an increase or build up of blood that can't be pumped through the body. (medicinenet.com)
Physiology1
- Wondering if anyone out there in physiology-land can offer a layman's explanation of the difference between a hematoma and hyperemia. (biology-online.org)
Transient1
- Patients with hypercholesterolemia exhibited reduced FMD in response to transient hyperemia, but the response to sustained hyperemia was normal. (ahajournals.org)
Peak2
- time to reactive hyperaemia peak. (springer.com)
- There was shortening of the duration of reactive hyperemia and reduction of peak flow at lower temperatures. (ahajournals.org)
Neuronal1
- Given that neuronal metabolism relies almost exclusively on oxidative metabolism, all normal function, from control of motor activity to cognitive ability and memory acquisition, requires adequate delivery of oxygenated blood. (ahajournals.org)
Ischemic1
- The response is known as ischemic reactive hyperemia. (bio-medicine.org)
Systolic blood pr1
- Using mouthwash reduces the activity of this pathway, and some studies have shown that resting systolic blood pressure goes up after mouthwash is used for a few days. (news-medical.net)
Circulation13
- However, do we know what happens when proper blood circulation is hampered! (buzzle.com)
- Are we aware of the symptoms of poor blood circulation? (buzzle.com)
- Find out all you need to know about blood circulation from the comprehensive guide provided below. (buzzle.com)
- Heart plays a very important role in the circulation of blood. (buzzle.com)
- Individuals with poor blood circulation often complain about muscle cramps in legs, tingling in feet, reddish color of the skin, and slow healing of wounds and sores. (buzzle.com)
- Lack of proper blood circulation throughout the body can lead to many problematic symptoms, which may trigger the onset of many serious medical conditions. (buzzle.com)
- You might be dealing with a problem of poor blood circulation. (buzzle.com)
- Viewing the detrimental effects associated with poor blood circulation, one cannot afford to ignore the different symptoms associated with the same, no matter how trivial they may seem. (buzzle.com)
- Poor blood circulation can hamper the normal functioning of the body, leading to unwanted complications in the absence of proper treatment. (buzzle.com)
- Poor blood circulation in the legs and the feet can cause various health problems. (buzzle.com)
- Poor blood circulation can give rise to various distressing symptoms. (buzzle.com)
- The following Buzzle write-up provides information on simple ways to improve blood circulation. (buzzle.com)
- This build-up blocks normal blood flow and can reduce circulation to the legs, arms, stomach, or kidneys, in addition to increasing the risk for heart attack or stroke. (baycare.org)
Engorgement1
- An abnormal collection of fluid, often blood, causing engorgement in an organ or part. (thefreedictionary.com)
Elevated plus1
- Sham, BCCAO/R, VA and VA+ BCCAO/R. Chronic cerebral hypoperfusion was induced after 2 weeks of pretreatment by VA. Subsequently, sensorimotor scores, elevated plus maze tests, cerebral hyperemia, and BBB disruption were evaluated 72 h after 30 min of BCCAO. (springermedizin.de)