Blood Group Antigens: Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.ABO Blood-Group System: The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.Lewis Blood-Group System: A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.Rh-Hr Blood-Group System: Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.Kell Blood-Group System: Multiple erythrocytic antigens that comprise at least three pairs of alternates and amorphs, determined by one complex gene or possibly several genes at closely linked loci. The system is important in transfusion reactions. Its expression involves the X-chromosome.Kidd Blood-Group System: A group of antigens consisting principally of Jk(a) and Jk(b), determined by allelic genes. Amorphs are encountered. Antibodies of these substances are usually weak and quite labile, stimulated by erythrocytes.Duffy Blood-Group System: A blood group consisting mainly of the antigens Fy(a) and Fy(b), determined by allelic genes, the frequency of which varies profoundly in different human groups; amorphic genes are common.MNSs Blood-Group System: A system of universal human blood group isoantigens with many associated subgroups. The M and N traits are codominant and the S and s traits are probably very closely linked alleles, including the U antigen. This system is most frequently used in paternity studies.Blood Group Incompatibility: An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).Antigens: Substances that are recognized by the immune system and induce an immune reaction.Fucosyltransferases: Enzymes catalyzing the transfer of fucose from a nucleoside diphosphate fucose to an acceptor molecule which is frequently another carbohydrate, a glycoprotein, or a glycolipid molecule. Elevated activity of some fucosyltransferases in human serum may serve as an indicator of malignancy. The class includes EC 2.4.1.65; EC 2.4.1.68; EC 2.4.1.69; EC 2.4.1.89.Blood Grouping and Crossmatching: Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.Glycophorin: The major sialoglycoprotein of the human erythrocyte membrane. It consists of at least two sialoglycopeptides and is composed of 60% carbohydrate including sialic acid and 40% protein. It is involved in a number of different biological activities including the binding of MN blood groups, influenza viruses, kidney bean phytohemagglutinin, and wheat germ agglutinin.P Blood-Group System: A blood group related to the ABO, Lewis and I systems. At least five different erythrocyte antigens are possible, some very rare, others almost universal. Multiple alleles are involved in this blood group.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Lutheran Blood-Group System: A complex blood group system having pairs of alternate antigens and amorphic genes, but also subject to a dominant independently segregating repressor.I Blood-Group System: A blood group related both to the ABO and P systems that includes several different antigens found in most people on erythrocytes, in milk, and in saliva. The antibodies react only at low temperatures.Carbohydrate Sequence: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Isoantibodies: Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.Norovirus: A genus in the family CALICIVIRIDAE, associated with epidemic GASTROENTERITIS in humans. The type species, NORWALK VIRUS, contains multiple strains.Epitopes: Sites on an antigen that interact with specific antibodies.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Isoantigens: Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.Antigens, Tumor-Associated, Carbohydrate: Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.Erythrocyte Membrane: The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.FucoseOligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Anion Exchange Protein 1, Erythrocyte: A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Glycosphingolipids: Lipids containing at least one monosaccharide residue and either a sphingoid or a ceramide (CERAMIDES). They are subdivided into NEUTRAL GLYCOSPHINGOLIPIDS comprising monoglycosyl- and oligoglycosylsphingoids and monoglycosyl- and oligoglycosylceramides; and ACIDIC GLYCOSPHINGOLIPIDS which comprises sialosylglycosylsphingolipids (GANGLIOSIDES); SULFOGLYCOSPHINGOLIPIDS (formerly known as sulfatides), glycuronoglycosphingolipids, and phospho- and phosphonoglycosphingolipids. (From IUPAC's webpage)Trisaccharides: Oligosaccharides containing three monosaccharide units linked by glycosidic bonds.Glycolipids: Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)Hemagglutination: The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).Galactosyltransferases: Enzymes that catalyze the transfer of galactose from a nucleoside diphosphate galactose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.Antigens, Viral: Substances elaborated by viruses that have antigenic activity.N-Acetylgalactosaminyltransferases: Enzymes that catalyze the transfer of N-acetylgalactosamine from a nucleoside diphosphate N-acetylgalactosamine to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.Carbohydrate Conformation: The characteristic 3-dimensional shape of a carbohydrate.Glycoconjugates: Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). The major glycoconjugates are glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. (From Biochemical Nomenclature and Related Documents, 2d ed; From Principles of Biochemistry, 2d ed)Saliva: The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.Mucins: High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.Amino Sugars: SUGARS containing an amino group. GLYCOSYLATION of other compounds with these amino sugars results in AMINOGLYCOSIDES.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Hemagglutination Tests: Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)Caliciviridae Infections: Virus diseases caused by CALICIVIRIDAE. They include HEPATITIS E; VESICULAR EXANTHEMA OF SWINE; acute respiratory infections in felines, rabbit hemorrhagic disease, and some cases of gastroenteritis in humans.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Bacterial Adhesion: Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Helicobacter pylori: A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).Adhesins, Bacterial: Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.Antigens, CD55: GPI-linked membrane proteins broadly distributed among hematopoietic and non-hematopoietic cells. CD55 prevents the assembly of C3 CONVERTASE or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Antigens, Protozoan: Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.Adhesins, Escherichia coli: Thin, filamentous protein structures, including proteinaceous capsular antigens (fimbrial antigens), that mediate adhesion of E. coli to surfaces and play a role in pathogenesis. They have a high affinity for various epithelial cells.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Plasmodium vivax: A protozoan parasite that causes vivax malaria (MALARIA, VIVAX). This species is found almost everywhere malaria is endemic and is the only one that has a range extending into the temperate regions.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.Antigens, Polyomavirus Transforming: Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.Colonic Neoplasms: Tumors or cancer of the COLON.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Norwalk virus: The type species in the genus NOROVIRUS, first isolated in 1968 from the stools of school children in Norwalk, Ohio, who were suffering from GASTROENTERITIS. The virions are non-enveloped spherical particles containing a single protein. Multiple strains are named after the places where outbreaks have occurred.Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Gastric Mucosa: Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.Molecular Weight: The sum of the weight of all the atoms in a molecule.Rhamnose: A methylpentose whose L- isomer is found naturally in many plant glycosides and some gram-negative bacterial lipopolysaccharides.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Antigens, Fungal: Substances of fungal origin that have antigenic activity.Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Receptors, Cell Surface: Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.Antigens, Helminth: Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.H-2 Antigens: The major group of transplantation antigens in the mouse.Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.Immune Sera: Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Virus Attachment: The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.alpha-N-Acetylgalactosaminidase: A hexosaminidase with specificity for terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides.Urinary Bladder: A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Glycosylation: The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.Lectins: Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.Antigens, Viral, Tumor: Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Immune Tolerance: The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.Gastroenteritis: INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.Forssman Antigen: A glycolipid, cross-species antigen that induces production of antisheep hemolysin. It is present on the tissue cells of many species but absent in humans. It is found in many infectious agents.Carbohydrates: The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.HLA-DR Antigens: A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.Receptors, Antigen, T-Cell: Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Agglutination Tests: Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)Streptococcus: A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.Antigens, CD15: A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.O Antigens: The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Linkage relations of locus for X-borne type of Charcot-Marie-Tooth muscular atrophy and that for Xg blood groups. (1/741)

The locus for the X-borne type of Charcot-Marie-Tooth muscular atrophy is not close to the Xg locus and probably not within direct measurable distance of it.  (+info)

Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108. (2/741)

CDw108, also known as the John-Milton-Hagen human blood group Ag, is an 80-kDa glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein that is preferentially expressed on activated lymphocytes and E. The molecular characteristics and biological function of the CDw108 were not clarified previously. In this manuscript, we identify the cDNA clone containing the entire coding sequence of the CDw108 gene and report its molecular characteristics. The 1998-base pairs of the open reading frame of the cloned cDNA encoded a protein of 666 amino acids (aa), including the 46 aa of the signal peptide and the 19 aa of the GPI-anchor motif. Thus, the membrane-anchoring form of CDw108 was the 602 aa, and the estimated molecular mass of the unglycosylated form was 68 kDa. The RGD (Arg-Gly-Asp) cell attachment sequence and the five potential N-linked glycosylation sites were located on the membrane-anchoring form. Flow cytometric and immunoprecipitation analyses of the CDw108 cDNA transfectants confirmed that the cloned cDNA encoded the native form of CDw108. The CDw108 mRNA was expressed in activated PBMCs as well as in the spleen, thymus, testis, placenta, and brain, but was not expressed in any other tissues tested. Radiation hybrid mapping indicated that the CDw108 gene was located in the middle of the long arm of chromosome 15 (15q23-24). This molecular information will be critical for understanding the biological function of the CDw108 Ag.  (+info)

Acquisition of human blood group antigens by Schistosoma mansoni. (3/741)

Juvenile forms of Schistosoma mansoni (schistosomula) have been cultured in human blood of various specificities and tested for the presence of blood group substances on their surfaces. The tests employed were survival following transfer into rhesus monkeys immunized against human blood substances, mixed agglutination reactions, and immunofluorescence. A, B, H AND Lewisb+ antigens were expressed at the surface when the parasites were cultured in blood of appropriate specificities. Rhesus, M N S, AND Duffy antigens could not be detected on the parasite surface following culture. The evidence suggests that the expressed blood group antigens are of host origin and are acquired by the parasite during culture, probably in the form of glycolipids or megaloglycolipids. It is likely that these substances are also acquired by parasites in the bloodstream of man. They may serve to mask surface parasite antigens, and so enable schistosomes to evade parasite-specific humoral or cellular immune responses.  (+info)

The expression of human blood group antigens during erythropoiesis in a cell culture system. (4/741)

Phenotypic analysis of hematopoietic stem and progenitor cells has been an invaluable tool in defining the biology of stem cell populations. We use here flow cytometry to examine the expression of human erythroid-specific surface markers during the maturation of early committed erythroid cells derived from cord blood in vitro. The temporal order of the expression of erythroid specific markers was as follows: Kell glycoprotein (gp), Rh gp, Landsteiner Wiener (LW) gp, glycophorin A (GPA), Band 3, Lutheran (Lu) gp, and Duffy (Fy) gp. The time at which some of these markers appeared suggests possible roles for some of these erythroid-specific polypeptides during the differentiation of these committed progenitors. The early appearance of Kell gp raises the possibility that it may have an important role in the early stages of hematopoiesis or cell lineage determination. Kell gp may also be a useful marker for the diagnosis of erythroleukemia. The late expression of Lu gp suggests it may be involved in the migration of erythroid precursors from the marrow. Fy gp is also expressed late consistent with a role as a scavenger receptor for cytokines in the bone marrow and circulation. Rh c antigen appeared before Rh D antigen, and it is suggested that this may reflect a reorganization of the developing erythroid cell membrane involving the Rh polypeptides and other components, including GPA and Band 3.  (+info)

The LWb blood group as a marker of prehistoric Baltic migrations and admixture. (5/741)

Archaeological findings and historical records indicate frequent migrations and exchange of genetic material between populations in the Baltic Sea area. However, there have so far been very few attempts to trace migrations in this area using genetic markers. We have studied the Baltic populations with respect to exceptional variations in the frequencies of the Landsteiner-Wiener (LW) blood group. The frequency of the uncommon LWb gene was high in the Balts, around 6% among Latvians and Lithuanians, very low among the other western Europeans (0-0.1%) and apparently absent in Asiatic and African populations. From the Baltic region of peak frequency there was a regular decline of LWb incidence (a descending cline) in the neighboring populations: 4.0% in the Estonians, 2.9% in the Finns, 2. 2% in the Vologda Russians, and 2.0% in the Poles. Thus the distribution of LWb suggests considerable and extensive Baltic admixture, especially in the north and northeast direction. In Southern Sweden with an LWb frequency of 0.3%, the Baltic influence appeared slight, while in the population of the Swedish island Gotland in the middle of the Baltic Sea there was a significantly increased LWb frequency of 1.0% compared with that of Western European countries. The distinction of codominantly inherited LW antigenic forms, LWa and LWb (previously Nea), is known to be due to a single base substitution. Based on our population data, it is plausible that the expansion of this point mutation occurred only once during human history. Furthermore, our data indicate that the expansion of the LWb mutation occurred in Balts and that LWb can be considered a 'Baltic tribal marker', its presence in other populations being an indicator of the degree of Baltic genetic influence.  (+info)

Studies on the structure and I-blood-group activity of poly(glycosyl)ceramides. (6/741)

Employing a modified technique of acetolysis, which allows almost a complete recovery of constituent sugars from poly(glycosyl)ceramides, the glycolipids were found to contain an excess of N-acetylglucosamine over galactose. On the basis of Smith degradation, methylation study, chromium trioxide degradation and the structures of oligosaccharides released from the glycolipids by partial acid hydrolysis, the presence of two types of sugar sequences has been established in poly(glycosyl)ceramides: a) Galbeta1 leads to 4GlcNAcbeta1 leads to 6Gal3 comes from R1 b) Galbeta1 leads to 4GlcNAcbeta1 leads to 4GlcNAc1 leads to R2. The repeating unit of poly(glycosyl)ceramides seems to be the GlcNAcbeta1 leads to 3Gal sequence. The specificity of one anti-I serum (Woj) is directed against the non-reducing ending of the first kind of chain. Three other anti-I sera reacted with inner portions of the oligosaccharide chains of the glycolipids.  (+info)

Novel method for evaluation of the oligomeric structure of membrane proteins. (7/741)

Assessment of the quaternary structure of membrane proteins by PAGE has been problematic owing to their relatively poor solubility in non-dissociative detergents. Here we report that several membrane proteins can be readily solubilized in their native quaternary structure with the use of the detergent perfluoro-octanoic acid (PFO). Further, PFO can be used with PAGE, thereby providing a novel, accessible tool with which to assess the molecular mass of homo-multimeric protein complexes.  (+info)

Interaction between cytochalasin B-treated malarial parasites and erythrocytes. Attachment and junction formation. (8/741)

We have previously demonstrated that invasion of erythrocytes (RBCs) by malaria merozoites follows a sequence: recognition and attachment in an apical orientation associated with widespread deformation of the RBC, junction formation, movement of the junction around the merozoite that brings the merozoite into the invaginated RBC membrane, and sealing of the membrane. In the present paper, we describe a method for blocking invasion at an early stage in the sequence. Cytochalasin-treated merozoites attach specifically to host RBCs, most frequently by the apical region that contains specialized organelles (rhoptries) associated with invasion. The parasite then forms a junction between the apical region and the RBC. Cytochalasin blocks movement of this junction, a later step in invasion. Cytochalasin-treated (Plasmodium knowlesi) merozoites attach to Duffy-negative human RBCs, although these RBCs are resistant to invasion by the parasite. The attachment with these RBCs, however, differs from susceptible RBCs in that there is no junction formation. Therefore the Duffy associated antigen appears to be involved in junction formation, not initial attachment.  (+info)

Foreword. Preface.. Some abbreviations used.. 1 Human Blood Groups: Introduction, Terminology, and Functions.. 2 ABO, H, and Lewis systems.. 3 MNS Blood Group System.. 4 P Blood Groups.. 5 Rh Blood Group System.. 6 Lutheran Blood Group System.. 7 Kell Blood Group System.. 8 Duffy Blood Group System.. 9 Kidd Blood Group System.. 10 Diego Blood Group System.. 11 Yt Blood Group System.. 12 Xg Blood Group System.. 13 Scianna Blood Group System and the Radin Antigen.. 14 Dombrock Blood Group System.. 15 Colton Blood Group System.. 16 LW Blood Group System.. 17 Chido/Rodgers Blood Group System.. 18 Gerbich Blood Group System.. 19 Cromer Blood Group System.. 20 Knops Blood Group System and the Cost Antigens.. 21 Indian Blood Group System and the AnWj Antigen.. 22 Ok Blood Group System.. 23 RAPH Blood Group System.. 24 JMH Blood Group System.. 25 Ii Antigens and Cold Agglutination.. 26 Er Antigens.. 27 Low Frequency Antigens.. 28 High Frequency Antigens.. 29 Sid Antigen.. 30 HLA (Human ...
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How is Gerbich (blood group system) abbreviated? GE stands for Gerbich (blood group system). GE is defined as Gerbich (blood group system) frequently.
Virus entry depends on biomolecular recognition at the surface of cell membranes. In the case of glycolipid receptors, these events are expected to be influenced by how the glycan epitope close to the membrane is presented to the virus. This presentation of membrane associated glycans is more restricted than that of glycans in solution, particularly because of orientational constraints imposed on the glycolipid through its lateral interactions with other membrane lipids and proteins. We have developed and employed a total internal reflection fluorescence microscopy-based binding assay and. a scheme for molecular dynamics (MD) membrane simulations to investigate the consequences of various glycan presentation effects. The system studied was histo-blood group antigen (HBGA) epitopes of membrane-bound glycosphingolipids (GSLs) derived from small intestinal epithelium of humans (type 1 chain) and dogs (type 2 chain) interacting with GII.4 norovirus-like particles. Our experimental results showed ...
We describe here the development of tools to specifically extract and dissect 43 blood group-related genes from 2504 individuals and to match them with the current set of blood group variants as defined by ISBT, the official body responsible for blood group nomenclature used for clinical and scientific reporting worldwide. To our knowledge, this study reports the first in-depth analysis of all 36 blood group systems in such a large and ethnically diverse NGS dataset. Blood group prediction based on NGS has been on the horizon for several years now, but interest was further sparked by introduction of this technology into tissue typing laboratories.18 Earlier this year, NGS-based blood group and platelet phenotype predictions were reported for a single individual in a proof-of-principle study.20 All blood group systems except XG were assessed, and ,200 antigens were predicted, 17 of which were serologically confirmed.. In total, 90.1% of all alleles from 1000G could be matched with already known ...
Blood group antigen (Science: haematology, immunology) The set of cell surface antigens found chiefly, but not solely, on blood cells. More than fifteen different blood group systems are recognised in humans. There may be naturally occurring antibodies without immunisation, especially in the case of the ABO system and matching blood groups is important for safe transfusion. in most cases the antigenic determinant resides in the carbohydrate chains of membrane glycoproteins or glycolipids. ...
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Mouse Monoclonal Anti-Lewis A Blood Group Antigen Antibody (7LE) [Alexa Fluor® 488]. Validated: WB, ELISA, IHC, IHC-P. Tested Reactivity: Human. 100% Guaranteed.
The Yt antigen system (also known as Cartwright) is present on the membrane of red blood cells and helps determine a persons blood type. The antigens are found on the protein acetylcholinesterase, an enzyme which helps break down acetylcholine. The Yt system features two alleles, Yt(a) and Yt(b). Antibodies against the Yt system can lead to transfusion reactions such as hemolytic anemia. Online Mendelian Inheritance in Man (OMIM) 112100 - OMIM page on Yt antigen Bartels, CF; Zelinski, T; Lockridge, O (1993). "Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism". American Journal of Human Genetics. 52 (5): 928-36. PMC 1682033 . PMID 8488842. Yt at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, ...
The CD44 antigens are transmembrane glycoproteins and members of the hyaladherin family of hyaluronan-binding proteins. Multiple CD44 isoforms have been described, the predominant form being CD44S, a glycoprotein of 85 kDa. CD44 is present on most cells or tissues, but not on platelets, hepatocytes, cardiac muscle, kidney tubular epithelium, testis and skin portions. The human blood group antigens Ina/b reside on CD44. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.
Blood group antigens are polymorphic residues of protein or carbohydrate on the red cell surface. They can provoke an antibody response in individuals who lack them, and some antibodies can lead to hemolytic transfusion reaction or hemolytic disease of the fetus/newborn (HDFN). Researchers have identified the molecular basis of many red cell blood group antigens, and an actively maintained database currently lists more than 1,600 alleles of 44 genes. A mini-review, published in the March issue of CLN, describes the major applications of the explosion of knowledge in blood group genetics to the practice of blood banking and transfusion medicine.
We have focused on finding ways to improve transfusion safety. We have studied blood group alloimmunization, i.e. the development of antibodies to red blood cells that occurs in some patients after transfusion. These antibodies are important since they can make it difficult to find compatible blood. They also mediate destruction of transfused red blood cells and transfusion reactions. We found that these antibodies are more dangerous than previously thought due to their higher rate of disappearance over time than previously thought. Their disappearance causes them to become undetectable during transfusion compatibility testing, yet their levels increase dramatically following transfusion of incompatible red blood cells. We have also studied the tendency of some patients to develop more than one blood group antibody. Currently, we are investigating ways to better detect and prevent blood group antibodies. We have also studied how to better prepare and store platelets for transfusion. Platelets ...
The term human blood group systems is defined by International Society of Blood Transfusion as systems in the human species where cell-surface antigens-in particular, those on blood cells-are "controlled at a single gene locus or by two or more very closely linked homologous genes with little or no observable recombination between them", and include the common ABO and Rh- (Rhesus) antigen systems, as well as many others; thirty-five major human systems are identified as of November 2014. In addition to the ABO and Rh systems, the antigens expressed on blood cell membrane surfaces include 346 red blood cell antigens and 33 platelet antigens, as defined serologically.[better source needed] The genetic basis for most of these antigens lie in 45 red blood cell and 6 platelet genes.[citation needed] An individual, for example, can be AB RhD positive, and at the same time M and N positive in the MNS system, K positive in the Kell system, and Lea or Leb positive in the Lewis system,[citation needed] ...
[A]lthough erythrocytes have traditionally been considered relatively inert cellular containers of hemoglobin, they are in fact active in a variety of physiologic processes. L. Calhoun and L. D. Petz(p1843) | Blood groups are characterized by erythrocyte (red blood cell) antigens with common immunologic properties (eg, group A). Blood group systems are series of such antigens encoded by a single gene or by a cluster of 2 or 3 closely linked homologous genes (eg, ABO system). There are about 600 recognized erythrocyte antigens. The International Society of Blood Transfusion (ISBT) designates around 270 blood group antigens. Of these, around 250 belong to
[A]lthough erythrocytes have traditionally been considered relatively inert cellular containers of hemoglobin, they are in fact active in a variety of physiologic processes. L. Calhoun and L. D. Petz(p1843) | Blood groups are characterized by erythrocyte (red blood cell) antigens with common immunologic properties (eg, group A). Blood group systems are series of such antigens encoded by a single gene or by a cluster of 2 or 3 closely linked homologous genes (eg, ABO system). There are about 600 recognized erythrocyte antigens. The International Society of Blood Transfusion (ISBT) designates around 270 blood group antigens. Of these, around 250 belong to
Good question minheesunwoo. Apart from our DNA everyones blood is a little bit different based on their blood groups. When you hear of blood groups most people think of ABO positive and negative groups, which are only 2 blood grouping systems, in reality there are around 30 blood group systems!. A blood group is how a person blood is classified based on things called antigens which are on the surface of the red blood cells. These antigens can be made of proteins, carbohydrates, glycoproteins or glycoproteins, depending on which blood group system we are talking about. Sometimes these blood group antigens can be found on other type of body tissues as well (which can become important especailly when a patient is having an organ transplant or becoming a donor for a transplant). In the 30 blood groups over 600 antigens have been found, but many of them are extremely rare and can often be found only in certain ethnic groups. If a person is exposed to an antigen (for example from a blood transfusion) ...
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Associations between blood type and disease have been studied since the early 1900s when researchers determined that antibodies and antigens are inherited. In the 1950s, the chemical identification of the carbohydrate structure of surface antigens led to the understanding of biosynthetic pathways. The blood type is defined by oligosaccharide structures, which are specific to the antigens, thus, blood group antigens are secondary gene products, while the primary gene products are various glycosyltransferase enzymes that attach the sugar molecules to the oligosaccharide chain.
A constant association exists between ka and the blood group antigen called M (5,6) and between Ka and another antigen called L (7,8). Recently Ellory and Tucker (8) have reported the exciting observation that treatment of LK erythrocytes with anti-L antiserum dramatically stimulates the cation transport system, effectively conferring HK properties on the LK cell. 51 GEORGE J. BREWER ET AL. Because the erythrocytes of newborn lambs of all genotypes are HK and do not react with M antisera, we felt that a study of the sequential development of adult characteristics in the lamb red cells might shed light on important interrelationships. Thus, a microbe with A activity would successfully infect type A individuals, and after the epidemic had subsided, the residual population would contain fewer type A individuals, ^hjischel (51) has reviewed the experimental evidence relating to the existence of blood group substance activity in plague and smallpox organisms and finds the evidence in both to be such ...
Looking for Lu Blood Group? Find out information about Lu Blood Group. The erythrocyte antigens defined by reactions with an antibody designated anti-Lu a , initially detected in the serum of a multiply transfused patient with... Explanation of Lu Blood Group
The 1962 report of the discovery of a sex-linked A blood group system, termed Xga, has been a recent stimulus to the study of X-linked inheritance in man. This presentation reviews the contributions of this system to medical science and discusses its proposed interaction with the male-to-female birth ratio.. Family studies of Xga by numerous investigators have permitted the mapping of the X chromosome for genes for muscular dystrophy, hemophilia, color blindness, and many other conditions in relationship to the Xga marker gene. Xga studies in Klinefelters and Turners syndromes have permitted the tracing of the parental origin of the ...
Blood from 130 older, isolated, agricultural Lumbees did not show significant genetic contributions from Cherokees, Blacks or Seminoles. Lumbees "could have undergone admixture with early White settlers and Tuscarora Indians" (p. 37).. ...
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Complete information for KNOP1 gene (Protein Coding), Lysine Rich Nucleolar Protein 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
The first blood group antigen system, recognized in 1900, was ABO, the most important in transfusion medicine. The major blood groups of this system are A, B, AB, and O. O type RBCs lack A or B antigens. These antigens are carbohydrates attached to a precursor backbone, may be found on the cellular membrane either as glycosphingolipids or glycoproteins, and are secreted into plasma and body fluids as glycoproteins. H substance is the immediate precursor on which the A and B antigens are added. This H substance is formed by the addition of fucose to the glycolipid or glycoprotein backbone. The subsequent addition of N-acetylgalactosamine creates the A antigen, while the addition of galactose produces the B antigen. ...
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JOHN H. VAUGHAN, MARION V. WALLER; Immunologic Features of Erythrocyte Sensitization : II. The Nature of Blood Group Antibodies. Blood 1957; 12 (3): 314. doi: https://doi.org/10.1182/blood.V12.3.314.314. Download citation file:. ...
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My wife is pregnant. As per the doctors advice, we got her blood tested. Her blood group emerged as A positive in 2 different labs. Prior to this her blood group was O positive. Even during her birth it was this. |b|We are unable to comprehend how her blood group can change|/b|. Could you please explain if this is possible and would there be any complications due to this?
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At the time of 28 weeks an injection has to be given to help prevent this problem. Anyhow there will not be much problem with first baby. But still its healthy for an RH "-ve" female to marry an RH"+"ve male with the help of initial medical invention. There is no complication when RH "-"ve male marries RH"+" female. Anyway, It is safer for an RH"-ve" Female to marry an RH"-ve" ...
Radin is a rare red cell antigen symbolized Rd(a) (OMIM 111620, 111750 locus 1p34) by translocating polymeric IgA and IgM on the mechanism which is located between PGM1 (171900) and alpha-fucosidase--Rh, which is located between PGM1 (171900) and alpha-fucosidase--Rh, concerning the Rh:Sc [Scianna polymorphisms] linkage reminiscent of that observed in subacute combined degeneration (SCD) of human SC[2.] along a given myelinated neurological axon and exon-intron junctions in particular their relationship to axonal demyelination while it was spotty is similar to the (PN) peripheral nerve is not mandatorily connected with months of feeding a Cbl-D diet[2.]. In hemispheric myelin[1.] in terms of the degree of myelination and of ODC [L-ornithine decarboxylase] seems to induce a type of regression in the SC of totally gastrectomized rats toward neonatal life, a complex fatty neural tissue insulates many nerves of the central and peripheral nervous systems. Without myelin antiserum Sc[1.], nerves are ...
One theory is that blood group antigens can act as binding receptors which will allow viruses or bacteria to attach and enter the bodys cells.
Question - Does negative blood group cause difficulty in conception and complications in pregnancy?. Ask a Doctor about Blood group, Ask an OBGYN, Gynecologic Oncology
Blood group typing market report provides insights into global blood group typing market. Market segmented on basis of product & service, test type, technique, end user, & region. Geographic analysis for these segments also presented in this report. Leading players in market are profiled to study their product offerings and understand strategies undertaken by them to be competitive in this market.
The AB0 system has been established as a risk factor or protection associated with the development of multiple pathologies. Thus, the search continues..
手機推薦醫療實用APP《Hemo bioscience》在本站分享如何使用APP、APP攻略詳情以及破解版APP供網友免費下載路徑行動醫療app,雲端醫療app找好用醫療 APP?免費APP快訊都在這裡推薦,android醫療appA unique reference database of blood group antigens and antibody characteristics for immunohematology/blood bank.【免費APP-Hemo bioscience APP試玩不用錢】醫療APP
Have you ever wondered what it is made of. Its not all sperm, there are a lot of other components that makes up ones man milk. Such as; vitamin C which is very good for tissue maintenance, blood-group antigens that are good for the immune system, calcium, citric acid, DNA, fructose, Glycoproteins a cancer fighting agent, vitamin B12, zinc, and selenium which is another cancer fighting agent. The list goes on and on of what you find in semen. Dont worry ladies if you are on a diet, because there is only about 5-7 calories per teaspoon. Unless you drink a glass of semen a day, the nutrients found in it really wont do much for you if you only swallow once or twice a day. I guess Im going to have to up my blow job quota for the month. Another good reason to swallow is you have less of a chance of developing preeclampsia; a high blood pressure disorder that can come with pregnancy ...
Blood groups are classified according to different marker proteins on the surface of red blood cells. These marker proteins called antigens...
Suppose the couple gave birth to only two children and they happen to share the two antigens equally among themself; that means the sharing will be in the ratio 1:1. With this explaination it is easy to see that I or you do not need punnet square to determine the ratio of the blood group of the children ...
... , Authors: Judith Weidenhofer, Leonie K Ashman. Published in: Atlas Genet Cytogenet Oncol Haematol.
Although all blood is made of the same basic elements, not all blood is alike. Understand your blood group and its compatibility here.
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I have come to know that the American population and our population can have a cross match of their donors to make the best match depending on blood groups and tissue typing that our population will also benefit from the American technology and international funding that this may attract because of our difference in financing and insurance costing resulting in savings to American tax payers and gain to Kenyans. The thing we need to embark on now is to educate our masses. Organ donation is a taboo in our culture. I lead from the front and offer my organs in the event of my death to be harvested and used to save lives and research to improve our knowledge of science. We must be our brothers keeper, he said ...
A recent study found that people with A, B, and AB blood types may be at greater risk of cardiovascular diseases, particularly heart attacks.
CD55 antibody [Bu14] (CD55 molecule (Cromer blood group)) for FACS. Anti-CD55 mAb (GTX41914) is tested in Human samples. 100% Ab-Assurance.
A group of learners models the Sun shining on the Earth. By rotating the Earth, they demonstrate how the Sun only shines on a portion of the Earth at a time. Learners understand why there are ...
Dina Mulder We had a form to fill in and her teacher as well, but there is no option to give answers to the questions. only strongly agree, agree, etc... which makes no sense to me. We had a 2 hrs interview prior my daughter having her 1 hours play/interview done by professionals in an Autism center. I trusted the team, but was worried they would not see her as she really is as she happened to have a good day that day of her play/interview. SHe has 2 personalities/modes. The sweet girl who cooperates, understands things and the other one who doesnt get anything, even if she understood them a day before, gets frustrated, tantrums, doesnt get along with anyone, etc... she doesnt do well with transitions, always covers her ears for noise, doesnt do well in group activities, etc.... but they never saw her in those situations. I was told they would observe her at school and at home, but they never did. not enough time and rushed things up. They are the only center where they do those ...
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... definition. Explain ABO blood group system. What is ABO blood group system? ABO blood group system meaning. ABO blood group system sense. ABO blood group system FAQ. ABO blood group system synonyms.
It is well known that ABO blood group system incompatible kidney transplantation (ABOi-KT) is an effective strategy for end-stage renal disease. The main barrier for ABOi-KT is how to keep host B cell activation and blood group antibody titer in low levels. Moreover, the mechanism of B cell activation induced by blood group antigen was unclear in ABOi-KT. In this study, HK2 cells were identified to express blood group B antigen when cocultured with lymphocytes of blood group A. Optical microscope observation demonstrated that HK2 cells in coculture group gradually decreased. Furthermore, flow cytometer assay identified that T cell phenotypes (CD3+, CD3+CD4+ and CD3+CD8+) had no significant change and B cell phenotypes (CD19+ and CD138+) were all significantly enhanced (3.07 and 3.02 folds) at day 4. In addition, immunoturbidimetry analysis demonstrated that blood group B antibody was significantly increased to 2.35 fold at day 4, IgG was significantly increased to 3.60 and 2.81 folds at days 4 and 8
Synonyms for ABO blood group system in Free Thesaurus. Antonyms for ABO blood group system. 2 synonyms for ABO blood group system: ABO group, ABO system. What are synonyms for ABO blood group system?
|p|Although the precise biological role of lysosomal membrane-associated glycoproteins (LAMPs) and ABH histo-blood group antigens (HBGAs) remains somewhat unclear, they are thought to be related to cell differentiation, cellular adhesion, and tumorigenesis. Here, we present the first comparative immunohistochemical study of both LAMPs and HBGAs in normal and neoplastic skin. Their localization is compared to that of high molecular weight cytokeratin and cytokeratin MNF 116. LAMPs and HBGA were differentially expressed in the normal stratified squamous epithelium, suggesting that they are involved in the initial steps of the differentiation process, whereas HBGAs are characteristic of terminal keratinocyte differentiation. No change in the reactivity for HBGA was detected in the stratified epithelium overlying squamous cell or basal cell carcinomas, whereas a considerable loss of LAMPs was detected. LAMPs were overexpressed in tumor cells, whereas HBGAs were lost in tumor zones of
In the process of ABO-incompatible (ABOi) organ transplantation, removal of anti-A and/or B antibodies from blood plasma is a promising method to overcome hyperacute rejection and allograft loss caused by the immune response between anti-A and/or B antibodies and the A and/or B antigens in the recipient. Although there are commercial columns to do this work, the application is still limited because of the high production cost. In this study, the PglB glycosylation pathway from Campylobacter jejuni was exploited to produce glycoprotein conjugated with Escherichia coli O86:B7 O-antigen, which bears the blood group B antigen epitope to absorb blood group B antibody in blood. The titers of blood group B antibody were reduced to a safe level without changing the clotting function of plasma after glycoprotein absorption of B antibodies in the plasma. We developed a feasible strategy for the specific adsorption/removal of blood group antibodies. This method will be useful in ABOi organ transplantation and
In the 2 large, prospective cohorts of the NHS and HPFS, we observed a significantly elevated risk of incident CHD for participants with blood group A or B or AB, compared with those with blood group O. The highest risk was observed for blood group AB, followed by blood groups B and A. The association between ABO blood group and CHD risk was not significantly modified by other known risk factors for CHD, including age, sex, alcohol consumption, smoking, physical activity, or diabetes mellitus history. In total, 6.27% of CHD cases were attributable to a non-O blood group (A, B, or AB blood types). A meta-analysis of 6 prospective studies indicated that non-O blood group was associated with an 11% increased risk of CHD compared with O blood group.. Associations between ABO blood groups and CHD have been investigated for several decades. However, the results have been conflicting, especially for the prospective cohort studies. Recently a meta-analysis reported that individuals with non-O blood ...
Individuals that become immunized to red blood cell (RBC) alloantigens can experience an increased rate of antibody formation to additional RBC alloantigens following subsequent transfusion. Despite this, how an immune response to one RBC immunogen may impact subsequent alloimmunization to a completely different RBC alloantigen remains unknown. Our studies demonstrate that Kell blood group antigen (KEL) RBC transfusion in the presence of inflammation induced by poly (I:C) (PIC) not only enhances anti-KEL antibody production through a CD4+ T-cell-dependent process but also directly facilitates anti-HOD antibody formation following subsequent exposure to the disparate HOD (hen egg lysozyme, ovalbumin, fused to human blood group antigen Duffy b) antigen ...
Introduction. The red blood cell (RBC) membrane contains many anchored surface proteins and proteins that cross the lipid bilayer carrying different blood group antigens. Currently, 36 systems1 of RBC groups have been described according to the International Society of Blood Transfusion (ISBT) (http://www.isbtweb.org). Among them, the Kidd blood group system (JK; ISBT 009) has been recognized as clinically important since its identification in 1951.2. Antigens of the Kidd blood group system are expressed on type 3 glycoproteins, also known as the urea transporter B (UT-B). This protein contains 389 amino acids and passes ten times through the lipid bilayer with both the N terminus and C terminus being intracellular. Three antigens have been found (Jka, Jkb and Jk3) on the neighboring fourth extracellular looping and three phenotypes, Jk(a+b−), Jk(a−b+), and Jk(a+b+), are common among different populations. The Jk(a−b−) phenotype is rare in most populations. It was first found in a ...
(2007) Cavasini et al. Malaria Journal. BACKGROUND: Duffy blood group polymorphisms are important in areas where Plasmodium vivax predominates, because this molecule acts as a receptor for this protozoan. In the present study, Duffy bloo...
ABO blood group system: ABO blood group system, classification of human blood as determined by the presence or absence of A and B antigens on red blood cells.
This site allows the access to the slide presentation Dr. Fumiichiro Yamamoto made at the IMPPC in September, 2009, on the molecular genetic basis of histo-blood group ABO system. The title of his talk was What You Had Better Know About ABO Blood Groups and a variety of topics relating to the ABO blood groups were discussed, including From History to Modern Genetics, From Red Blood Cell to Kidney, Hair, Seminal Fluid, From Blood Transfusion, Cell/Tissue/Organ Transplantation to Crime Scene Investigation, and From Humans to Animals. All the slides are listed as figures in the jpg format.
This site allows the access to the slide presentation Dr. Fumiichiro Yamamoto made at the IMPPC in September, 2009, on the molecular genetic basis of histo-blood group ABO system. The title of his talk was What You Had Better Know About ABO Blood Groups and a variety of topics relating to the ABO blood groups were discussed, including From History to Modern Genetics, From Red Blood Cell to Kidney, Hair, Seminal Fluid, From Blood Transfusion, Cell/Tissue/Organ Transplantation to Crime Scene Investigation, and From Humans to Animals. All the slides are listed as figures in the jpg format.
article{ea473a25-ecbc-4f85-99b7-9f9455af3f89, title = {Qualitative and quantitative analysis of the binding of GII.4 norovirus variants onto human blood group antigens}, author = {de Rougemont, A. and Ruvoen-Clouet, N. and Simon, Beno\^{\i}t and Estienney, M. and Elie-Caille, C\{e}line and Aho, S. and Pothier, M. and Le Pendu, J. and Boireau, Wilfrid and Belliot, G.}, year = {2011}, month = {may}, number = {9}, pages = {4057 - 4070}, volume = {85}, doi = {http://dx.doi.org/10.1128%2FJVI.02077-10}, journal = {Journal of Virology}, publisher = {American Society for Microbiology (ASM ...
The distribution of blood group carbohydrate chains with antigen A, B, H type 2 chain (A and B precursor), and N-acetyllactosamine (H type 2 precursor) specificity was studied in human oral epithelium from different anatomical regions. These represented various epithelial differentiation patterns such as non-keratinized, parakeratinized, and orthokeratinized stratified squamous epithelium. The material included buccal and palatal epithelium from 20 persons with blood group A or O, gingival, and alveolar epithelium from 10 persons with blood group A or B, and buccal metaplastically keratinized epithelium from nine blood group A, two blood group B, and nine blood group O individuals. The blood group carbohydrate chains were examined in tissue sections by immunofluorescence microscopy. The A and B blood group antigens were detected by human blood group sera, and antigen H type 2 chains and N-acetyllactosamine by murine monoclonal antibodies. Each antigen showed a similar staining pattern in buccal ...
JERSEY, Channel Islands, Oct. 14, 2016 (GLOBE NEWSWIRE) - Quotient Limited ("Quotient") (NASDAQ:QTNT), a commercial-stage diagnostics company, today announced the completion of a private placement of up to $120 million of 12% Senior Secured Notes due 2023. At the initial closing of the transaction, Quotient issued $84 million of notes and received net proceeds of approximately $79 million after expenses. Quotient will issue an additional $36 million of notes to note purchasers upon public announcement of field trial results for the MosaiQ™ IH Microarray that demonstrates greater than 99% concordance for the detection of blood group antigens and greater than 95% concordance for the detection of blood group antibodies when compared to predicate technologies for a pre-defined set of blood group antigens and antibodies. Quotient intends to use the net proceeds from this transaction, among other things, to repay all outstanding obligations to MidCap Financial Trust under its existing loan agreement ...
The relationship of the ABO blood groups to various diseases has received increasing attention of late. Thus, Aird et al.1 report that "the frequency of blood group A is greater and the frequency of blood group O less in patients suffering from cancer of the stomach than in the general population of the locality in which they live." Blood group O has been reported to be strikingly high, and the other three blood groups increasingly low, in patients suffering from peptic ulcer.2 Studies have revealed an inverse relationship between the frequencies of blood groups O and A in patients with ...
Two new members of the Ig superfamily, the Lutheran (Lu) blood group glycoprotein and the B-cell adhesion molecule (B-CAM) epithelial cancer antigen, have been recently cloned from human placenta and colon cancer HT29 cell line, respectively. Although amino acid sequences deduced from cDNA analysis suggested that B-CAM should represent an abridged form of the Lu glycoprotein lacking the last 40 amino acids of the putative cytoplasmic tail, the relationship between the genes encoding these polypeptides has not been determined. In the present report, we showed by Southern blot analysis that the Lu and B-CAM cDNAs derived from a unique LU gene which exhibited an HindIII RFLP associated with the Lua/Lub blood group polymorphism. Accordingly, in situ hybridization of the Lu cDNA probe confirmed the localization of the Lutheran blood group locus to chromosome 19 q13.2-13.3, as previously shown for a B-CAM DNA probe. Sequence comparison between cDNA and genomic PCR fragments indicated that the Lu and ...
Unit 9 Other Blood Group Systems Part 1. Terry Kotrla, MS, MT(ASCP)BB. Introduction. ISBT recognizes 30 blood group systems with over 600 antigens. Some VERY rare only found in certain ethnic groups. Some associated with diseases or resistance to infection. Most important are ABO and D...
A human blood group A specific lectin is present in crude extracts of Vicia villosa seeds. The lectin has been purified by affinity chromatography on immobilized type A substance 1 , on immobilized α galactose 2 , and on immobilized porcine blood group substance 3 . Lectin yields and characteristics can vary depending on the method used for isolation. As reported by Tollefsen and Kornfeld, VVA is a tetramer composed of 2 different subunits. Three related isolectins, composed of different amounts of the two subunits, have been purified. The A4 isolectin (composed of four A subunits) is responsible for the anti-A1 blood group activity. The B4 isolectin, which is composed of four B subunits, has been crystallized in the presence of carbohydrate and preliminary diffraction data obtained to 2.8Å 4 . By circular dichroism, its conformation has been shown to be primarily β-sheets, and it is exceptionally resistant to denaturation by chaotropic reagents such as 6M guanidine hydro-chloride or 7.5mM ...
ABO blood group phenotype is determined by the expression of specific antigens on red blood cells, endothelial cells, platelets, and many other cells and tissues. The presence of A or B antigen results in the expression of A, B, or AB phenotype, whereas the lack of both A and B antigen results in the expression of the O phenotype. These ABH antigens comprise complex terminal carbohydrate molecules on glycoproteins and glycolipids, generated by the addition of N-acetylgalactosamine (A antigen) or d-galactose (B antigen) to existing N-glycan and O-glycan structures through the action of the ABO glycosyltransferases.7 The A and B alleles of the ABO locus encode A and B glycosyltransferases, which in turn catalyze the transfer of the different carbohydrates onto a common core H antigen, to form an A or B antigen. However, type O individuals only express H antigen because the O isoform of ABO lacks glycosyltransferase activity.8. In the past, studies have associated ABO blood groups with CVD, whereby ...
The ABO blood group system is the best known blood typing system, determining blood group type as A, B, AB, or O, and thereby of importance for blood donors and recipients. Wikipedia Three common alleles (A, B and O) of the ABO gene yield the six common combinations that a person can have, each of them resulting in a particular ABO blood type (as determined serologically): ...
The nurses led by Mandy Smith, Linda Almay, and Andrea Hubbard, supported by dermatology doctors led by Dr Nick Levell , developed the Cromer dermatology service initally as an offshoot from the Dermatology department at the Norfolk and Norwich University Hospital. The doctors still work in both departments whereas the nurses at Cromer and District Hospital have now created an individual unit which is able to offer the same specialised services as those available in Norwich.. There are now three medical consultants, Dr Nick Levell, Dr George Millington and Dr Anne-Marie Skellett and nurse consultant Carrie Wingfield supported by Dr Mark Fleming, a North Norfolk GP with expertise in dermatology, which enables the service to offer a wide range of treatments and increase the number of people treated at Cromer. Dr Millington has a clinic on Wednesday morning and has a biopsy list on Wednesday afternoon. Dr Skellett has a clinic on Tuesday am with an operating list in the afternoon. Carrie Wingfield ...
Looking for online definition of Chido-Rodgers blood group in the Medical Dictionary? Chido-Rodgers blood group explanation free. What is Chido-Rodgers blood group? Meaning of Chido-Rodgers blood group medical term. What does Chido-Rodgers blood group mean?
Background Previous studies have examined the association between ABO blood group and the risk of some malignancies. However, no prospective cohort study to date has examined the association between ABO blood group and the risk of skin cancer. Methodology/Principal Findings Using two large cohorts in the US, we examined ABO blood type and incidence of skin cancer, including melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC). We followed up study participants (70,650 female nurses and 24,820 male health professionals) on their diagnosis of incident skin cancer from cohort baseline (1976 in women and 1986 in men) until 2006. Study participants reported their blood type in 1996 in both cohorts. During the follow-up, 685 participants developed melanoma, 1,533 developed SCC and 19,860 developed BCC. We used Cox proportional hazards models to calculate the hazard ratios (HR) and 95% confidence intervals (CI) of each type of skin cancer. We observed that non-O blood group (A, AB, and B
Procedures-Sample selection was purposely biased toward those from anemic, type B, or type AB cats or those with autoagglutination. All blood samples were tested by use of GEL, SLIDE, and TUBE methods. Fifty-eight samples were also tested by use of CARD and CHROM methods. The presence of alloantibodies in all cats expressing the B antigen as detected by use of any method was also assessed ...
Every person belongs to one of eight blood groups. These blood groups, or blood types, are sub-types of the four larger ABO blood groups - A, B, AB or O. The Rhesus (Rh) system further divides these four groups into either Rh+ or Rh-, leaving eight blood groups: O-, O+, B-, B+, A-, A+, AB- or AB+.
annotations (the reliablity of the annotated protein expression using immunohistochemically (IH) stained on human tissues, the reliablity of the annotated protein expression in immunofluorescently (IF) stained human cell lines, tissue specificity (the distribution of antibody staining or protein expression in human cell types), cell line specificity (the distribution of RNA abundance in cell lines) and subcellular location (based on immunofluorescent staining of cell lines ...
Genetic variations in ABO define the ABO blood group system [MIM:616093]. The ABO blood group system is the most important blood group system in blood transfusion. The sequence shown here is that of the A transferase. The B form differs by a few residues substitution. Residues 266 and 268 are important for specificity. The reference genome assembly (GRCh38/hg38) describes a non-functional O-type ABO allele. The O-type ABO allele results in a guanine deletion (NM_020469.2: c.286delG). This deletion induces a frameshift and creates a premature stop codon resulting in a truncated (117 amino acids) protein deprived of any glycosyltransferase activity (PubMed:2333095 ...
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Low-ionic-strength saline (LISS) techniques permit a safe and substantial reduction in incubation time and have therefore become the method of choice for antibody detection and compatibility testing in many transfusion laboratories. Consequently, the supply of reagent red cells (RBCs) in a low-ionic-strength preservative solution would remove the daily need for laboratories to wash and resuspend cells in LISS before use. However, the storage of fresh RBCs at low ionic strength in the presence of aminoglycoside antibiotics can cause a rapid loss of certain antigens, possibly as a result of the release of proteolytic enzymes from contaminating white cells. This article describes a low-ionic-strength solution that achieves preservation of antigens on liquid nitrogen-frozen-thawed RBCs for 21 days storage at 4°C. ...
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Why dont antibodies of o blood group does not cause agglutination reaction with any of antigens in other blood group? Study Blood Types Review.
Blood group test showing reactions between blood types and antibody sera. There are four human blood types: A, B, AB and O. Type A blood has type A antigens (surface proteins) on its red blood cells and anti-B antibodies (proteins that bind to type B antigens) in its serum. Type B blood is the reverse. AB blood has no antibodies, but has both A and B antigens on its cells. Type O blood has both antibodies but no antigens. The blood type is identified by adding an antibody serum containing either only anti-A, only anti-B or both anti-A and anti-B. Identifying the blood type prevents patients from having fatal immune responses when receiving donated blood. - Stock Image C001/3317
Fax: 01263 646192. The hospital is on Mill Road, opposite the Cromer Football Club. Mill Road can be found off the main A149, via Cromwell Road.. Facilities include an ophthalmic operating theatre plus new diagnostic services including a permanent on-site mammography (breast screening) service, and a DEXA scanner for osteoporosis diagnosis. A brand new MRI scanner was also installed in late 2010.. The old Davison and Barclay ward areas of the current hospital have been retained and refurbished for use as a permanent renal dialysis unit with room for expansion.. ...
3ONY: Crystal Structures of GII.10 and GII.12 Norovirus Protruding Domains in Complex with Histo-Blood Group Antigens Reveal Details for a Potential Site of Vulnerability.
3PA2: Crystal Structures of GII.10 and GII.12 Norovirus Protruding Domains in Complex with Histo-Blood Group Antigens Reveal Details for a Potential Site of Vulnerability.
SWISS-MODEL Template Library (SMTL) entry for 2zl7.1. Atomic resolution structural characterization of recognition of histo-blood group antigens by Norwalk virus
Our blood types are genetic, meaning we inherit our blood type from our parents. According to the ABO blood group system, there are four major blood groups
ABO blood group, the major human blood group system, dependent on the presence or absence of A and B antigens, which are largely glycolipids on the cell membrane. The gene for A is responsible for synthesis of N-acetyl-α-d-galactosaminyl transferase, whereas that for B is responsible for α-d-galactosyl transferase. Either A or B is created when one of these hexasaccharides is positioned by a specific transferase in 1→3 linkage to the β-d-galactose of an H-active oligosaccharide. Type O occurs when neither transferase is present or, very rarely (Bombay phenotype), when H antigen does not exist. When both transferases are present, type AB results. Differences in degree of transferase activity are determined at the same locus: weak transferase gives rise to weak antigens (A2, A3Ax, B3Bx). Similar oligosaccharides, especially in bacterial cell walls, immunize persons lacking A or B so that their serum contains anti-A or anti-B activity. A and B antigens are on the mucopolysaccharides of ...
Aquaporin 1: Aquaporin 1 forms a water-specific channel that is constitutively expressed at the PLASMA MEMBRANE of ERYTHROCYTES and KIDNEY TUBULES, PROXIMAL. It provides these cells with a high permeability to WATER. In humans polymorphisms of this protein result in the Colton blood group antigen.
While my guitar gently weeps Musings on the seduction of technology | By Pat Letendre Aprils blog focuses on news items from TraQs latest newsletter that have a commonality. The main item deals with a molecular assay to identify 35 red cell antigens from 11 blood groups. The other, included to illustrate the blogs theme but mainly here for fun, focuses on the clinical uses of platelet-rich plasma (PRP). Ill leave it to readers to ascertai...
The GRC prioritizes curation efforts that improve gene representation in the human reference genome assembly. In some cases, such curation takes the form of base-pair level edits. The recent GRCh38.p11 patch release includes a new, curated, representation for the GCNT2 gene. The representation of the GCNT2 gene in the GRCh38 reference assembly contains the "C" allele for SNP rs539351 on chromosome 6 (NC_000006.12) at position 10,586,805, which reflects the sequence from the underlying component AL358777.12 (RP11-421M1) (Figure 1, top). During human development, the fetal blood group antigen (i) is converted to the adult antigen (I) by a beta-1,6-N-acetylglucosaminyltransferase-2 (GCNT2). Alternative splicing of the gene generates 3 isoforms, which differ only in their first exon. The SNP rs539351 is found in the first exon unique to the GCNT2 isoform C, which is the only one expressed in red blood cells, where this conversion occurs (NM_145655.3: c.816C,G (NP_663630.2: p.Asp272Glu). A user ...
The GRC prioritizes curation efforts that improve gene representation in the human reference genome assembly. In some cases, such curation takes the form of base-pair level edits. The recent GRCh38.p11 patch release includes a new, curated, representation for the GCNT2 gene. The representation of the GCNT2 gene in the GRCh38 reference assembly contains the "C" allele for SNP rs539351 on chromosome 6 (NC_000006.12) at position 10,586,805, which reflects the sequence from the underlying component AL358777.12 (RP11-421M1) (Figure 1, top). During human development, the fetal blood group antigen (i) is converted to the adult antigen (I) by a beta-1,6-N-acetylglucosaminyltransferase-2 (GCNT2). Alternative splicing of the gene generates 3 isoforms, which differ only in their first exon. The SNP rs539351 is found in the first exon unique to the GCNT2 isoform C, which is the only one expressed in red blood cells, where this conversion occurs (NM_145655.3: c.816C,G (NP_663630.2: p.Asp272Glu). A user ...
Clinical Biochemistry: diagnosis, screening and monitoring of disease through qualitative and quantitative evaluation. Diagnosis of Liver, Cardiac diseases and endocrine disorders. Drug toxicity and drug monitoring Haematology and Transfusion Science: haematology of normal and disease states, haemoglobinopathies and thalassaemias, anaemias, leukaemias and thrombosis. Laboratory investigation of disease states. The role of the laboratory in monitoring of therapy. Immunohaematology; including identification of blood group antigens, methods for antibody detection and compatibility testing and safety aspects of blood transfusion ...
The AB system is the major blood group system in domestic cats. The common blood types are A and B. Cats with bloodtype B have anti-A antibodies at a high titer and cats with blood type A have anti-B antibodies at a low titer. Cats with the rare AB blood type do not have anti-A or anti-B antibodies ...
Principal Investigator:KOMINATO Yoshihiko, Project Period (FY):2003 - 2004, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Legal medicine
Non-secretor: Sperm does not contain blood-group antigens.[127]. *Physically agile and capable of sprinting, bicycling, and ... This group of officials is in charge of prosecuting the case against DeAngelo, the alleged Golden State Killer. He was ...
"ABO blood group and related antigens, natural antibodies and transplantation". Tissue Antigens. 68 (6): 459-466. doi:10.1111/j. ... is an antigen found on red blood cells; individuals that are Rh-positive (Rh+) have this antigen on their red blood cells and ... "Blood Groups and Red Cell Antigens. NCBI Bethesda (MD): National Library of Medicine (US),.. ... Antibody-antigen interactions[edit]. The antibody's paratope interacts with the antigen's epitope. An antigen usually contains ...
ABO blood group and related antigens, natural antibodies and transplantation. Tissue Antigens. December 2006, 68 (6): 459-466. ... Blood Groups and Red Cell Antigens. NCBI Bethesda (MD): National Library of Medicine (US),. 2005.. ... 抗體的某些部分具有獨特的功能。比如說Y形的臂區,包含了兩個可以結合抗原的位點,是識別外來物的關鍵所在。該區域被稱為Fab區,即抗原
"Norovirus and histo-blood group antigens". Consultado o 22 December 2012.. *↑ Hutson, AM; Atmar RL, Graham DY, Estes MK (July ... Shirato H (2011). "Norovirus and histo-blood group antigens". Jpn. J. Infect. Dis. 64 (2): 95-103. PMID 21519121.. ... Shirato H (2011). "Norovirus and histo-blood group antigens". Japanese Journal of Infectious Diseases 64 (2): 95-103. PMID ... "The P Domain of Norovirus Capsid Protein Forms Dimer and Binds to Histo-Blood Group Antigen Receptors". J. Virol. 78 (12): 6233 ...
1997). "The Oka blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, ... Ok blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH ... This protein is a determinant for the Ok blood group system. Basigin has been shown to be an essential receptor on red blood ... "Entrez Gene: BSG basigin (Ok blood group)".. *^ Kanekura T, Chen X, Kanzaki T (2002). "Basigin (CD147) is expressed on melanoma ...
Tan M, Hegde RS, Jiang X (2004). "The P Domain of Norovirus Capsid Protein Forms Dimer and Binds to Histo-Blood Group Antigen ... GII.4 includes global epidemic strains and binds to more Histo-blood group antigens than other genogroups. A Japanese study in ... Reports have shown a link between the expression of human histo-blood group antigens (HBGAs) and the susceptibility to ... Shirato H (2011). "Norovirus and histo-blood group antigens". Jpn. J. Infect. Dis. 64 (2): 95-103. PMID 21519121. Nordgren J, ...
5: The ABO blood group". Blood Groups and Red Cell Antigens. Bethesda MD: National Center for Biotechnology Information. ... Gene map locus 19p13.2 BSG: Basigin (Ok blood group)/Extracellular matrix metalloproteinase inducer/CD147. Gene map locus ... The enzyme it encodes catalyzes the production of H antigen. MORT (Mortal Obligate RNA Transcript, lincRNA): Gene map locus ... Gene map locus 19q13.32 PNMA8A: paraneoplastic Ma antigen family member 8A 19q13.32 DMPK: Dystrophia myotonica-protein kinase. ...
Cartron JP (Dec 1994). "Defining the Rh blood group antigens. Biochemistry and molecular genetics". Blood Reviews. 8 (4): 199- ... Rh blood group, D antigen also known as Rh polypeptide 1 (RhPI) or cluster of differentiation 240D (CD240D) is a protein that ... The RHD gene codes for the RhD erythrocyte membrane protein that is the Rh factor antigen of the Rh blood group system. RHD has ... Avent ND, Reid ME (Jan 2000). "The Rh blood group system: a review". Blood. 95 (2): 375-87. PMID 10627438. Denomme GA, Wang D, ...
Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the ... IFC and UMC antigens. Complement receptor type 1 (C3b/C4b receptor) (Antigen CD35) belongs to the Knops blood group system and ... Complement decay-accelerating factor (Antigen CD55) belongs to the Cromer blood group system and is associated with Cr(a), Dr(a ... Lomas-Francis, Christine; Reid, Marion E. (2004). The blood group antigen: factsbook. Boston: Academic Press. ISBN 0-12-586585- ...
Each calf expressed both sets of paternal blood group antigens. Owen's "analyses revealed that the twins were chimeric, each ... The lab studied blood samples from cattle all over the world, investigating genetic markers and the inheritance of red blood ... red blood cell types in cattle twins in 1945 launched the fields of modern immunology and organ transplantation. Owen's 1945 ... containing their own blood cells as well as those derived from their twin sibling." These twins were immunologically compatible ...
I. Molecular characterization of ABH and Colton blood group antigens". J. Clin. Invest. 94 (3): 1043-9. doi:10.1172/JCI117418. ... Zelinski T, Kaita H, Lewis M, Coghlan G, Philipps S, Belcher E, McAlpine PJ, Coopland G, Wong P (1988). "The Colton blood group ... Colton blood group)". Knepper MA (1994). "The aquaporin family of molecular water channels". Proc. Natl. Acad. Sci. U.S.A. 91 ( ... Aquaporin Colton antigen system GRCh38: Ensembl release 89: ENSG00000240583 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...
This encoded protein might carry the M blood group antigen. GYPA, GYPB, and GYPE are organized in tandem on chromosome 4. This ... Kudo S, Fukuda M (1994). "Contribution of gene conversion to the retention of the sequence for M blood group type determinant ... Blood. 80 (9): 2379-87. PMID 1421409. Vignal A, London J, Rahuel C, Cartron JP (1991). "Promoter sequence and chromosomal ...
"Allelic genes of blood group antigens: a source of human mutations and cSNPs documented in the Blood Group Antigen Gene ... The BGMUT (Blood Group antigen gene MUTation) Database documents allelic variations in the genes encoding for human blood group ... "Blood Group Antigen Gene Mutation Database (BGMUT)". dbRBC. NCBI at the NIH. Retrieved 2011-07-17. ... In addition to being a repository of the genetic variations of the blood group antigen-encoding genes, the database also ...
"BGMUT Blood Group Antigen Gene Mutation Database". Retrieved 2011-07-16. Alexander WS, Viney EM, Zhang JG, et al. (October 2006 ... C1GALT1 is associated with the T-Tn antigen system. There is some evidence that mutations in the C1GALT1 gene may be associated ...
Evidence that the antigens of the Yt blood group system are located on human erythrocyte acetylcholinesterase.. Blood. 1992, 80 ... Coamplification of human acetylcholinesterase and butyrylcholinesterase genes in blood cells: correlation with various ...
The O antigen of LPS may be fucosylated and mimic Lewis blood group antigens found on the gastric epithelium.[16] The outer ... "Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging". Science. 279 (5349): 373-7. ... Noninvasive tests for H. pylori infection may be suitable and include blood antibody tests, stool antigen tests, or the carbon ... In October 1987, a group of experts met in Copenhagen to found the European Helicobacter Study Group (EHSG), an international ...
MNS blood group)". Blumenfeld OO, Adamany AM, Puglia KV, Socha WW (April 1983). "The chimpanzee M blood-group antigen is a ... Chalmers JN, Ikin EW, Mourant AE (July 1953). "A study of two unusual blood-group antigens in West Africans". Br Med J. 2 (4829 ... Reference needed] The MNS blood group was the second set of antigens discovered. M and N were identified in 1927 by Landsteiner ... Blumenfeld OO, Huang CH (1996). "Molecular genetics of the glycophorin gene family, the antigens for MNSs blood groups: ...
Stormorken, H & Erikssen J.. xF VIII levels and blood group antigens. Thromb. Haemost. 1984;51:292 Ørstavik, KH; Stormorken, H ... Erikssen, J; Thaulow, E; Stormorken, H; Brendemoen, O; Hellem, A (18 June 1980). "ABO blood groups and coronary heart disease ( ... "Reduced thrombus formation in native blood of homozygous factor VII-deficient patients at high arterial wall shear rate". Blood ... Thaulow, E; Erikssen, J; Sandvik, L; Stormorken, H; Cohn, PF (August 1991). "Blood platelet count and function are related to ...
Crew VK, Green C, Daniels G (2004). "Molecular bases of the antigens of the Lutheran blood group system". Transfusion. 43 (12 ... blood group polymorphism". Blood. 89 (12): 4608-16. PMID 9192786. Parsons SF, Lee G, Spring FA, et al. (2001). "Lutheran blood ... 1997). "Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily ... 1995). "The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human ...
In 1972 a numerical system for the antigens in this blood group was introduced. Despite the similar names glycophorin C and D ... This antigen is also known as the Rs(a) antigen. The Ahonen (Ana) antigen was first reported in 1972. The antigen is found on ... Glycophorin A and glycophorin B carry the blood group MN and Ss antigens respectively. There are ~225,000 molecules of GPC and ... Furuhjelm U, Nevanlinna HR, Gavin J, Sanger R (December 1972). "A rare blood group antigen An a (Ahonen)". Journal of Medical ...
"ABO blood group and related antigens, natural antibodies and transplantation". Tissue Antigens 68 (6): 459-466. 10.1111/j.1399- ... Interakcije antitijelo-antigen[uredi VE , uredi]. Paratop protutijela reagira s epitopom antigena. Antigen obično sadrži ... Rh faktor, također poznat kao Rh D antigen, je antigen pronađen na crvenim krvnim stanicama; pojedinci koji su Rh-pozitivni (Rh ... Važno je napomenuti da se to događa prije nego što antigen može stimulirati majčinske B stanice da "sjećaju" Rh antigen ...
ISBN 978-0-9558648-7-2. Laura, Dean (2005). Blood Groups and Red Cell Antigens. Bethesda, United States: National Center for ... Macrophages then recognise these IgG antibodies and engulf these red blood cells, removing the red blood cells from the blood ... the most severe of which often involves group A red cells being given to a patient with group O type blood. Properdin then ... The most common cause of this reaction is ABO blood groups incompatibility, secondary to human errors. In this process, the ...
Knops blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH This article incorporates text from ... The Knops antigen was the 25th blood group system recognized and consists of the single antigen York (Yk) a with the following ... The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to ... Rao N, Ferguson DJ, Lee SF, Telen MJ (1991). "Identification of human erythrocyte blood group antigens on the C3b/C4b receptor ...
Molecular biology and evolution of blood group and MHC antigens in primates. Springer Science & Business Media. ISBN 3-642- ... It was expected that groups with similar proportions of blood groups would be more closely related, but instead it was often ... Before the discovery of DNA, scientists used blood proteins (the human blood group systems) to study human genetic variation. ... and self-identified race or ethnic groups does not mean that such a cluster (or group) corresponds to only one ethnic group. ...
The class I genes were discovered in 1936 (the year Jan Klein was born) as coding for blood group (red blood cell) antigens, ... Immunogenetics emerged in the 1930s as the study of genes controlling antigens (such as those of the various blood group ... Molecular Biology and Evolution of Blood Group and MHC antigens in Primates. Springer-Verlag, Berlin 1997. Klein, J. and ... In this respect, the antigens fell into two groups as if carried by two different molecules. The discovery of the class II ...
doi:10.1182/blood-2010-05-283770.. *^ Belikov AV, Schraven B, Simeoni L. T cells and reactive oxygen species. Journal of ... T-cell Group - Cardiff University. *(Successful!) Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO- ... MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution. Proceedings of the National ... Blood Cancer Journal. July 2015, 5 (7): e330. PMC 4526784. PMID 26230954. doi:10.1038/bcj.2015.58 (英语).. ...
ABO blood group system, classification of human blood as determined by the presence or absence of A and B antigens on red blood ... ABO blood group system, the classification of human blood based on the inherited properties of red blood cells (erythrocytes) ... The A, B, and O blood groups were first identified by Austrian immunologist Karl Landsteiner in 1901. See blood group. ... blood group: Historical background. The human ABO blood groups were discovered by Austrian-born American biologist Karl ...
Buy our Recombinant Human Blood Group Antigen Precursor protein. Ab113153 is a full length protein produced in Escherichia coli ... This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, ... ABO blood group (transferase A alpha 1-3 N acetylgalactosaminyltransferase transferase B alpha 1 3 galactosyltransferase) ... and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by ...
Plasmodium vivax: merozoite antigens, the Duffy blood group, and erythrocyte invasion. Prog Clin Biol Res 313 : 1-11.. ... The Duffy-blood-group genotype, FyFy. N Engl J Med 295 : 302-304.. ... Persistence of humoral response against sporozoite and blood-stage malaria antigens 7 years after a brief exposure to ... Plasmodium vivax interaction with the human Duffy blood group glycoprotein: identification of a parasite receptor-like protein ...
Human blood group antigens are glycoproteins and glycolipids expressed on the surface of red blood cells and a variety of human ... compared with those with blood group O. The highest risk was observed for blood group AB, followed by blood groups B and A. The ... Red blood cell blood group antigens: structure and function. Semin Hematol. 2004;41:93-117. ... Assessment of ABO Blood Group. The assessment of ABO blood group has been described in detail elsewhere.23 Briefly, in both the ...
Most antibodies used in blood grouping must be searched for in immunized donors. Antibodies for MN typing are usually raised in ... Sources of antibodies and antigens: Normal donors are used as the source of supply of naturally occurring antibodies, such as ... One form of the gene codes for the M blood group, while the other form codes for the N blood group; different forms of the same ... his discovery of the major blood groups and the development of the ABO system of blood typing that has made blood transfusion a ...
... on blood cells. More than fifteen different blood group systems are recognised in humans. In most cases the antigenic ... Protein belonging to the set of cell surface antigens found chiefly, but not solely, ...
It accompanies the dbRBC, a new NCBI resource that contains clinical and DNA data about human red blood cells. ... Blood Groups and Red Cell Antigens is a guide to the differences in our blood types that complicate blood transfusions and ... Blood Groups and Red Cell Antigens. Blood Groups and Red Cell Antigens. ... Blood Groups and Red Cell Antigens is a guide to the differences in our blood types that complicate blood transfusions and ...
... Divjot Singh Lamba, Ravneet Kaur, and ... E. Smart and B. Armstrong, "Blood group systems," International Society of Blood Transfusion Science Series, vol. 3, pp. 68-92 ... "Minor Red cell antigens in north Indian blood donor population," Indian Journal of Hematology and Blood Transfusion, vol. 21, ... "Phenotype frequencies of blood group systems (Rh, Kell, Kidd, Duffy, MNS, P, Lewis, and Lutheran) in North Indian blood donors ...
Blood group antigen definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look ... blood group antigen. n.. *Any of various inherited antigens found on the surface of red blood cells that determine a blood ...
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The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood ... Blood group antigens include (A, B, and O (H). The blood group antigens are specific for all the blood group subtypes. By blood ... were each blood group antigen is expressed on a different core saccharide chain type. The blood group antigen is an A antigen, ... Blood group antigens include A antigen, B antigen and H antigen. Core saccharide chain types include type 1, type 2, type 3 and ...
... and blood group antigens, into their integuments. Their metabolism shifts to gly... more ... encoded search term (What is the role of histocompatibility complexes and blood group antigens in the pathophysiology of ... What is the role of histocompatibility complexes and blood group antigens in the pathophysiology of schistosomiasis (bilharzia ... and blood group antigens, into their integuments. Their metabolism shifts to glycolysis. The worms then migrate through the ...
Hirschsprungs disease Enterocolitis Blood group-associated antigens Mucin This is a preview of subscription content, log in to ... Coopers HS, Haesler WE (1978) Blood group substance as tumor antigen in distal colon. Am J Clin Pathol 69: 594-598Google ... Abnormal expression of blood group-associated antigen (BGA) in colon of Hirschsprungs disease. ... X and Y blood group antigens in human colonic tumors and normal tissue and human tumor derived cell lines. Cancer Res 46: 1553- ...
Blood group antigen (Science: haematology, immunology) The set of cell surface antigens found chiefly, but not solely, on blood ... More than fifteen different blood group systems are recognised in humans. There may be naturally occurring antibodies without ... Retrieved from "https://www.biology-online.org/dictionary/index.php?title=Blood_group_antigens&oldid=55843" ... especially in the case of the ABO system and matching blood groups is important for safe transfusion. ...
What You Had Better Know About ABO Blood Groups and a variety of topics relating to the ABO blood groups were discussed, ... including From History to Modern Genetics, From Red Blood Cell to Kidney, Hair, Seminal Fluid, From Blood Transfusion, ... Fumiichiro Yamamoto made at the IMPPC in September, 2009, on the molecular genetic basis of histo-blood group ABO system. The ... ABO BLOOD GROUP SYSTEM LECTURE SLIDE 059: .... the hypothesis of the biosynthetic pathways of A and B antigens from the common ...
What You Had Better Know About ABO Blood Groups and a variety of topics relating to the ABO blood groups were discussed, ... including From History to Modern Genetics, From Red Blood Cell to Kidney, Hair, Seminal Fluid, From Blood Transfusion, ... Fumiichiro Yamamoto made at the IMPPC in September, 2009, on the molecular genetic basis of histo-blood group ABO system. The ... ABO BLOOD GROUP SYSTEM LECTURE SLIDE 139: Those newly synthesized A and/or B antigens will be immunologically detected using ...
... Narender Kumar,1 Akhil Kapoor,2 Ashok Kalwar,3 ... D. Ichikawa, K. Handa, and S. Hakomori, "Histo-blood group A/B antigen deletion/reduction vs. continuous expression in human ... T. Chandra and A. Gupta, "Frequency of ABO and rhesus blood groups in blood donors," Asian Journal of Transfusion Science, vol ... "ABH and lewis histo-blood group antigens in cancer," Acta Pathologica, Microbiologica, et Immunologica Scandinavica, vol. 109, ...
Histo-Blood Group Antigen Presentation Is Critical for Binding of Norovirus VLP to Glycosphingolipids in Model Membranes. ... The system studied was histo-blood group antigen (HBGA) epitopes of membrane-bound glycosphingolipids (GSLs) derived from small ... molecular-dynamics simulations, epithelial-cells, glycolipid receptors, small-intestine, secretor fut2, abo-phenotype, group-a ...
Mouse monoclonal Blood Group Antigen B antibody [B460]. Validated in IHC and tested in Human. Immunogen corresponding to tissue ... This product Mouse Anti-Blood Group Antigen B antibody [B460] (ab129992) IHC-P, IHC-Fr ...
References for Abcams Recombinant Human Blood Group Kell Antigen protein (ab116891). Please let us know if you have used this ...
Deletion of antigens of the Lewis a/b blood group family in human prostatic carcinoma.. Young WW Jr1, Mills SE, Lippert MC, ... The expression of antigens of the blood group Lewis a/b family were studied in a series of 42 prostatectomy specimens from ... No cases in this latter group had recurrence of disease, whereas in the other staining groups 25-33% of the cases had ... No correlation was apparent between Gleason score and the staining pattern with these antigens. In summary, antigens of the ...
B and H Antigens antibody [HE-10] (ab2523) has been cited in 2 publications. Find out more about the references ... Vanak J et al. Detection of blood group A antigen expression in human colon cancer using monoclonal antibodies with different ... Anti-Blood Group A, B and H Antigens antibody [HE-10] (ab2523). ... Blood-Group-A-B-and-H-Antigens-antibody-HE-10-ab2523.pdf ...
Mouse monoclonal Blood Group B Antigen antibody [HEB-29] validated for IHC, Agg and tested in Human. Referenced in 2 ... Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They ... Mixture of erythrocytes of blood group B and glycoprotein fraction isolated from the saliva of secretors with blood group B. ... Detection of blood group A antigen expression in human colon cancer using monoclonal antibodies with different specificities.. ...
"The Anton blood group antigen is the erythrocyte receptor for Haemophilus influenzae". FEMS Microbiology Letters. 37 (1): 69-71 ... The Anton antigen is a cell surface receptor found on some human red blood cells. It has been observed to play a role in ... Studies showed that the bacterium can adhere to this receptor and cause human red blood cells to agglutinate. Alphen Loek; ...
Mouse monoclonal Blood Group H ab antigen antibody [87-N] validated for IP, ELISA, Agg and tested in Human. Immunogen ... Anti-Blood Group H ab antigen antibody [87-N]. See all Blood Group H ab antigen primary antibodies. ...
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