Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.
Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.
Multiple erythrocytic antigens that comprise at least three pairs of alternates and amorphs, determined by one complex gene or possibly several genes at closely linked loci. The system is important in transfusion reactions. Its expression involves the X-chromosome.
A group of antigens consisting principally of Jk(a) and Jk(b), determined by allelic genes. Amorphs are encountered. Antibodies of these substances are usually weak and quite labile, stimulated by erythrocytes.
A blood group consisting mainly of the antigens Fy(a) and Fy(b), determined by allelic genes, the frequency of which varies profoundly in different human groups; amorphic genes are common.
A system of universal human blood group isoantigens with many associated subgroups. The M and N traits are codominant and the S and s traits are probably very closely linked alleles, including the U antigen. This system is most frequently used in paternity studies.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
Substances that are recognized by the immune system and induce an immune reaction.
Enzymes catalyzing the transfer of fucose from a nucleoside diphosphate fucose to an acceptor molecule which is frequently another carbohydrate, a glycoprotein, or a glycolipid molecule. Elevated activity of some fucosyltransferases in human serum may serve as an indicator of malignancy. The class includes EC; EC; EC; EC
Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
The major sialoglycoprotein of the human erythrocyte membrane. It consists of at least two sialoglycopeptides and is composed of 60% carbohydrate including sialic acid and 40% protein. It is involved in a number of different biological activities including the binding of MN blood groups, influenza viruses, kidney bean phytohemagglutinin, and wheat germ agglutinin.
A blood group related to the ABO, Lewis and I systems. At least five different erythrocyte antigens are possible, some very rare, others almost universal. Multiple alleles are involved in this blood group.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
A complex blood group system having pairs of alternate antigens and amorphic genes, but also subject to a dominant independently segregating repressor.
A blood group related both to the ABO and P systems that includes several different antigens found in most people on erythrocytes, in milk, and in saliva. The antibodies react only at low temperatures.
The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Substances elaborated by bacteria that have antigenic activity.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
A genus in the family CALICIVIRIDAE, associated with epidemic GASTROENTERITIS in humans. The type species, NORWALK VIRUS, contains multiple strains.
Sites on an antigen that interact with specific antibodies.
Antibodies produced by a single clone of cells.
Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.
Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.
A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Lipids containing at least one monosaccharide residue and either a sphingoid or a ceramide (CERAMIDES). They are subdivided into NEUTRAL GLYCOSPHINGOLIPIDS comprising monoglycosyl- and oligoglycosylsphingoids and monoglycosyl- and oligoglycosylceramides; and ACIDIC GLYCOSPHINGOLIPIDS which comprises sialosylglycosylsphingolipids (GANGLIOSIDES); SULFOGLYCOSPHINGOLIPIDS (formerly known as sulfatides), glycuronoglycosphingolipids, and phospho- and phosphonoglycosphingolipids. (From IUPAC's webpage)
Oligosaccharides containing three monosaccharide units linked by glycosidic bonds.
Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)
The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).
Enzymes that catalyze the transfer of galactose from a nucleoside diphosphate galactose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.
Substances elaborated by viruses that have antigenic activity.
Enzymes that catalyze the transfer of N-acetylgalactosamine from a nucleoside diphosphate N-acetylgalactosamine to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.
The characteristic 3-dimensional shape of a carbohydrate.
Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). The major glycoconjugates are glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. (From Biochemical Nomenclature and Related Documents, 2d ed; From Principles of Biochemistry, 2d ed)
The clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin.
High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
SUGARS containing an amino group. GLYCOSYLATION of other compounds with these amino sugars results in AMINOGLYCOSIDES.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)
Virus diseases caused by CALICIVIRIDAE. They include HEPATITIS E; VESICULAR EXANTHEMA OF SWINE; acute respiratory infections in felines, rabbit hemorrhagic disease, and some cases of gastroenteritis in humans.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
Cell-surface components or appendages of bacteria that facilitate adhesion (BACTERIAL ADHESION) to other cells or to inanimate surfaces. Most fimbriae (FIMBRIAE, BACTERIAL) of gram-negative bacteria function as adhesins, but in many cases it is a minor subunit protein at the tip of the fimbriae that is the actual adhesin. In gram-positive bacteria, a protein or polysaccharide surface layer serves as the specific adhesin. What is sometimes called polymeric adhesin (BIOFILMS) is distinct from protein adhesin.
GPI-linked membrane proteins broadly distributed among hematopoietic and non-hematopoietic cells. CD55 prevents the assembly of C3 CONVERTASE or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.
Thin, filamentous protein structures, including proteinaceous capsular antigens (fimbrial antigens), that mediate adhesion of E. coli to surfaces and play a role in pathogenesis. They have a high affinity for various epithelial cells.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A protozoan parasite that causes vivax malaria (MALARIA, VIVAX). This species is found almost everywhere malaria is endemic and is the only one that has a range extending into the temperate regions.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Tumors or cancer of the COLON.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The type species in the genus NOROVIRUS, first isolated in 1968 from the stools of school children in Norwalk, Ohio, who were suffering from GASTROENTERITIS. The virions are non-enveloped spherical particles containing a single protein. Multiple strains are named after the places where outbreaks have occurred.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
The sum of the weight of all the atoms in a molecule.
A methylpentose whose L- isomer is found naturally in many plant glycosides and some gram-negative bacterial lipopolysaccharides.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Substances of fungal origin that have antigenic activity.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Established cell cultures that have the potential to propagate indefinitely.
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
The major group of transplantation antigens in the mouse.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.
A hexosaminidase with specificity for terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides.
A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
Transport proteins that carry specific substances in the blood or across cell membranes.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.
Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
INFLAMMATION of any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Causes of gastroenteritis are many including genetic, infection, HYPERSENSITIVITY, drug effects, and CANCER.
A glycolipid, cross-species antigen that induces production of antisheep hemolysin. It is present on the tissue cells of many species but absent in humans. It is found in many infectious agents.
The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Tests that are dependent on the clumping of cells, microorganisms, or particles when mixed with specific antiserum. (From Stedman, 26th ed)
A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.
A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Linkage relations of locus for X-borne type of Charcot-Marie-Tooth muscular atrophy and that for Xg blood groups. (1/741)

The locus for the X-borne type of Charcot-Marie-Tooth muscular atrophy is not close to the Xg locus and probably not within direct measurable distance of it.  (+info)

Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108. (2/741)

CDw108, also known as the John-Milton-Hagen human blood group Ag, is an 80-kDa glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein that is preferentially expressed on activated lymphocytes and E. The molecular characteristics and biological function of the CDw108 were not clarified previously. In this manuscript, we identify the cDNA clone containing the entire coding sequence of the CDw108 gene and report its molecular characteristics. The 1998-base pairs of the open reading frame of the cloned cDNA encoded a protein of 666 amino acids (aa), including the 46 aa of the signal peptide and the 19 aa of the GPI-anchor motif. Thus, the membrane-anchoring form of CDw108 was the 602 aa, and the estimated molecular mass of the unglycosylated form was 68 kDa. The RGD (Arg-Gly-Asp) cell attachment sequence and the five potential N-linked glycosylation sites were located on the membrane-anchoring form. Flow cytometric and immunoprecipitation analyses of the CDw108 cDNA transfectants confirmed that the cloned cDNA encoded the native form of CDw108. The CDw108 mRNA was expressed in activated PBMCs as well as in the spleen, thymus, testis, placenta, and brain, but was not expressed in any other tissues tested. Radiation hybrid mapping indicated that the CDw108 gene was located in the middle of the long arm of chromosome 15 (15q23-24). This molecular information will be critical for understanding the biological function of the CDw108 Ag.  (+info)

Acquisition of human blood group antigens by Schistosoma mansoni. (3/741)

Juvenile forms of Schistosoma mansoni (schistosomula) have been cultured in human blood of various specificities and tested for the presence of blood group substances on their surfaces. The tests employed were survival following transfer into rhesus monkeys immunized against human blood substances, mixed agglutination reactions, and immunofluorescence. A, B, H AND Lewisb+ antigens were expressed at the surface when the parasites were cultured in blood of appropriate specificities. Rhesus, M N S, AND Duffy antigens could not be detected on the parasite surface following culture. The evidence suggests that the expressed blood group antigens are of host origin and are acquired by the parasite during culture, probably in the form of glycolipids or megaloglycolipids. It is likely that these substances are also acquired by parasites in the bloodstream of man. They may serve to mask surface parasite antigens, and so enable schistosomes to evade parasite-specific humoral or cellular immune responses.  (+info)

The expression of human blood group antigens during erythropoiesis in a cell culture system. (4/741)

Phenotypic analysis of hematopoietic stem and progenitor cells has been an invaluable tool in defining the biology of stem cell populations. We use here flow cytometry to examine the expression of human erythroid-specific surface markers during the maturation of early committed erythroid cells derived from cord blood in vitro. The temporal order of the expression of erythroid specific markers was as follows: Kell glycoprotein (gp), Rh gp, Landsteiner Wiener (LW) gp, glycophorin A (GPA), Band 3, Lutheran (Lu) gp, and Duffy (Fy) gp. The time at which some of these markers appeared suggests possible roles for some of these erythroid-specific polypeptides during the differentiation of these committed progenitors. The early appearance of Kell gp raises the possibility that it may have an important role in the early stages of hematopoiesis or cell lineage determination. Kell gp may also be a useful marker for the diagnosis of erythroleukemia. The late expression of Lu gp suggests it may be involved in the migration of erythroid precursors from the marrow. Fy gp is also expressed late consistent with a role as a scavenger receptor for cytokines in the bone marrow and circulation. Rh c antigen appeared before Rh D antigen, and it is suggested that this may reflect a reorganization of the developing erythroid cell membrane involving the Rh polypeptides and other components, including GPA and Band 3.  (+info)

The LWb blood group as a marker of prehistoric Baltic migrations and admixture. (5/741)

Archaeological findings and historical records indicate frequent migrations and exchange of genetic material between populations in the Baltic Sea area. However, there have so far been very few attempts to trace migrations in this area using genetic markers. We have studied the Baltic populations with respect to exceptional variations in the frequencies of the Landsteiner-Wiener (LW) blood group. The frequency of the uncommon LWb gene was high in the Balts, around 6% among Latvians and Lithuanians, very low among the other western Europeans (0-0.1%) and apparently absent in Asiatic and African populations. From the Baltic region of peak frequency there was a regular decline of LWb incidence (a descending cline) in the neighboring populations: 4.0% in the Estonians, 2.9% in the Finns, 2. 2% in the Vologda Russians, and 2.0% in the Poles. Thus the distribution of LWb suggests considerable and extensive Baltic admixture, especially in the north and northeast direction. In Southern Sweden with an LWb frequency of 0.3%, the Baltic influence appeared slight, while in the population of the Swedish island Gotland in the middle of the Baltic Sea there was a significantly increased LWb frequency of 1.0% compared with that of Western European countries. The distinction of codominantly inherited LW antigenic forms, LWa and LWb (previously Nea), is known to be due to a single base substitution. Based on our population data, it is plausible that the expansion of this point mutation occurred only once during human history. Furthermore, our data indicate that the expansion of the LWb mutation occurred in Balts and that LWb can be considered a 'Baltic tribal marker', its presence in other populations being an indicator of the degree of Baltic genetic influence.  (+info)

Studies on the structure and I-blood-group activity of poly(glycosyl)ceramides. (6/741)

Employing a modified technique of acetolysis, which allows almost a complete recovery of constituent sugars from poly(glycosyl)ceramides, the glycolipids were found to contain an excess of N-acetylglucosamine over galactose. On the basis of Smith degradation, methylation study, chromium trioxide degradation and the structures of oligosaccharides released from the glycolipids by partial acid hydrolysis, the presence of two types of sugar sequences has been established in poly(glycosyl)ceramides: a) Galbeta1 leads to 4GlcNAcbeta1 leads to 6Gal3 comes from R1 b) Galbeta1 leads to 4GlcNAcbeta1 leads to 4GlcNAc1 leads to R2. The repeating unit of poly(glycosyl)ceramides seems to be the GlcNAcbeta1 leads to 3Gal sequence. The specificity of one anti-I serum (Woj) is directed against the non-reducing ending of the first kind of chain. Three other anti-I sera reacted with inner portions of the oligosaccharide chains of the glycolipids.  (+info)

Novel method for evaluation of the oligomeric structure of membrane proteins. (7/741)

Assessment of the quaternary structure of membrane proteins by PAGE has been problematic owing to their relatively poor solubility in non-dissociative detergents. Here we report that several membrane proteins can be readily solubilized in their native quaternary structure with the use of the detergent perfluoro-octanoic acid (PFO). Further, PFO can be used with PAGE, thereby providing a novel, accessible tool with which to assess the molecular mass of homo-multimeric protein complexes.  (+info)

Interaction between cytochalasin B-treated malarial parasites and erythrocytes. Attachment and junction formation. (8/741)

We have previously demonstrated that invasion of erythrocytes (RBCs) by malaria merozoites follows a sequence: recognition and attachment in an apical orientation associated with widespread deformation of the RBC, junction formation, movement of the junction around the merozoite that brings the merozoite into the invaginated RBC membrane, and sealing of the membrane. In the present paper, we describe a method for blocking invasion at an early stage in the sequence. Cytochalasin-treated merozoites attach specifically to host RBCs, most frequently by the apical region that contains specialized organelles (rhoptries) associated with invasion. The parasite then forms a junction between the apical region and the RBC. Cytochalasin blocks movement of this junction, a later step in invasion. Cytochalasin-treated (Plasmodium knowlesi) merozoites attach to Duffy-negative human RBCs, although these RBCs are resistant to invasion by the parasite. The attachment with these RBCs, however, differs from susceptible RBCs in that there is no junction formation. Therefore the Duffy associated antigen appears to be involved in junction formation, not initial attachment.  (+info)

Foreword. Preface.. Some abbreviations used.. 1 Human Blood Groups: Introduction, Terminology, and Functions.. 2 ABO, H, and Lewis systems.. 3 MNS Blood Group System.. 4 P Blood Groups.. 5 Rh Blood Group System.. 6 Lutheran Blood Group System.. 7 Kell Blood Group System.. 8 Duffy Blood Group System.. 9 Kidd Blood Group System.. 10 Diego Blood Group System.. 11 Yt Blood Group System.. 12 Xg Blood Group System.. 13 Scianna Blood Group System and the Radin Antigen.. 14 Dombrock Blood Group System.. 15 Colton Blood Group System.. 16 LW Blood Group System.. 17 Chido/Rodgers Blood Group System.. 18 Gerbich Blood Group System.. 19 Cromer Blood Group System.. 20 Knops Blood Group System and the Cost Antigens.. 21 Indian Blood Group System and the AnWj Antigen.. 22 Ok Blood Group System.. 23 RAPH Blood Group System.. 24 JMH Blood Group System.. 25 Ii Antigens and Cold Agglutination.. 26 Er Antigens.. 27 Low Frequency Antigens.. 28 High Frequency Antigens.. 29 Sid Antigen.. 30 HLA (Human ...
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Even though the International Society of Blood Transfusion has defined 38 blood group systems, only ABO and RhD are matched while selecting a compatible unit for blood recipients of Indian origin. Genetic disparity between a donor and a patient with reference to minor blood group antigens creates the risk of alloimmunization. The presence of red blood cell alloantibodies further creates the potential for serologic incompatibility, makes the selection of appropriate units for future transfusion more difficult, delays blood transfusion, and presents the risk of hemolytic disease of the newborn. Hence, there is a need to carry out extended blood group typing for antigens of clinical importance among donors and patients so that prophylactic antigen-matched blood can be given to a patient. Provision of antigen-matched blood will help in management of alloimmunized transfused-dependent patients carrying alloantibodies and/or autoantibodies. Typing of blood group antigens among large number of donors ...
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Mouse monoclonal antibody raised against native human Blood Group Antigen A. Mucin isolated from an ovarian cyst fluid. (MAB13290) - Products - Abnova
How is Gerbich (blood group system) abbreviated? GE stands for Gerbich (blood group system). GE is defined as Gerbich (blood group system) frequently.
Interpretive Summary: Human histo-blood group antigens (HBGA) have been identified previously as candidate receptors for human norovirus (NOR). HBGAs of blood group types A, H1 (related to O type), and Lewis have been identified as the major types that bind NOR. We have identified that pig stomach (gastric) mucin (PGM) also contains blood group A, H1, and Lewis (Lewis type b) HBGAs and binds more strains of NOR than do specific antibodies to NOR. NOR strains representing the I and II genogroups and present in dilute samples could be captured and concentrated by PGM-conjugated to magnetic beads, and NOR on beads were available for further processing. NOR present in a human patient fecal sample was detectable at a dilution of 1: 1,000,000 using the standard protocol RNA extraction procedure, whereas, NOR was detectable at a 1: 100,000,000 dilution due to efficient capture and concentration of NOR by PGM-beads. Moreover, NOR present in spiked complex food samples (e.g. oyster extract, strawberry, ...
Virus entry depends on biomolecular recognition at the surface of cell membranes. In the case of glycolipid receptors, these events are expected to be influenced by how the glycan epitope close to the membrane is presented to the virus. This presentation of membrane associated glycans is more restricted than that of glycans in solution, particularly because of orientational constraints imposed on the glycolipid through its lateral interactions with other membrane lipids and proteins. We have developed and employed a total internal reflection fluorescence microscopy-based binding assay and. a scheme for molecular dynamics (MD) membrane simulations to investigate the consequences of various glycan presentation effects. The system studied was histo-blood group antigen (HBGA) epitopes of membrane-bound glycosphingolipids (GSLs) derived from small intestinal epithelium of humans (type 1 chain) and dogs (type 2 chain) interacting with GII.4 norovirus-like particles. Our experimental results showed ...
We describe here the development of tools to specifically extract and dissect 43 blood group-related genes from 2504 individuals and to match them with the current set of blood group variants as defined by ISBT, the official body responsible for blood group nomenclature used for clinical and scientific reporting worldwide. To our knowledge, this study reports the first in-depth analysis of all 36 blood group systems in such a large and ethnically diverse NGS dataset. Blood group prediction based on NGS has been on the horizon for several years now, but interest was further sparked by introduction of this technology into tissue typing laboratories.18 Earlier this year, NGS-based blood group and platelet phenotype predictions were reported for a single individual in a proof-of-principle study.20 All blood group systems except XG were assessed, and ,200 antigens were predicted, 17 of which were serologically confirmed.. In total, 90.1% of all alleles from 1000G could be matched with already known ...
Blood group antigen (Science: haematology, immunology) The set of cell surface antigens found chiefly, but not solely, on blood cells. More than fifteen different blood group systems are recognised in humans. There may be naturally occurring antibodies without immunisation, especially in the case of the ABO system and matching blood groups is important for safe transfusion. in most cases the antigenic determinant resides in the carbohydrate chains of membrane glycoproteins or glycolipids. ...
Lewis A (Blood Group Antigen) Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone SPM522 ] validated in IHC, IF, FC (AH12955-100), Abgent
Blood Group Antigen A (CD173) Antibody - With BSA and Azide, Mouse Monoclonal Antibody [Clone HE-10 ] validated in IHC, IF (AH11359-20), Abgent
Mouse Monoclonal Anti-Lewis A Blood Group Antigen Antibody (7LE) [Alexa Fluor® 488]. Validated: WB, ELISA, IHC, IHC-P. Tested Reactivity: Human. 100% Guaranteed.
The Yt antigen system (also known as Cartwright) is present on the membrane of red blood cells and helps determine a persons blood type. The antigens are found on the protein acetylcholinesterase, an enzyme which helps break down acetylcholine. The Yt system features two alleles, Yt(a) and Yt(b). Antibodies against the Yt system can lead to transfusion reactions such as hemolytic anemia. Online Mendelian Inheritance in Man (OMIM) 112100 - OMIM page on Yt antigen Bartels, CF; Zelinski, T; Lockridge, O (1993). Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism. American Journal of Human Genetics. 52 (5): 928-36. PMC 1682033 . PMID 8488842. Yt at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, ...
International Society of Blood Transfusion (ISBT) Working Party has organized red cell antigens into 25 blood group systems. Red cell antigens that ar...
The CD44 antigens are transmembrane glycoproteins and members of the hyaladherin family of hyaluronan-binding proteins. Multiple CD44 isoforms have been described, the predominant form being CD44S, a glycoprotein of 85 kDa. CD44 is present on most cells or tissues, but not on platelets, hepatocytes, cardiac muscle, kidney tubular epithelium, testis and skin portions. The human blood group antigens Ina/b reside on CD44. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.
Blood group antigens are polymorphic residues of protein or carbohydrate on the red cell surface. They can provoke an antibody response in individuals who lack them, and some antibodies can lead to hemolytic transfusion reaction or hemolytic disease of the fetus/newborn (HDFN). Researchers have identified the molecular basis of many red cell blood group antigens, and an actively maintained database currently lists more than 1,600 alleles of 44 genes. A mini-review, published in the March issue of CLN, describes the major applications of the explosion of knowledge in blood group genetics to the practice of blood banking and transfusion medicine.
We have focused on finding ways to improve transfusion safety. We have studied blood group alloimmunization, i.e. the development of antibodies to red blood cells that occurs in some patients after transfusion. These antibodies are important since they can make it difficult to find compatible blood. They also mediate destruction of transfused red blood cells and transfusion reactions. We found that these antibodies are more dangerous than previously thought due to their higher rate of disappearance over time than previously thought. Their disappearance causes them to become undetectable during transfusion compatibility testing, yet their levels increase dramatically following transfusion of incompatible red blood cells. We have also studied the tendency of some patients to develop more than one blood group antibody. Currently, we are investigating ways to better detect and prevent blood group antibodies. We have also studied how to better prepare and store platelets for transfusion. Platelets ...
The term human blood group systems is defined by International Society of Blood Transfusion as systems in the human species where cell-surface antigens-in particular, those on blood cells-are controlled at a single gene locus or by two or more very closely linked homologous genes with little or no observable recombination between them, and include the common ABO and Rh- (Rhesus) antigen systems, as well as many others; thirty-five major human systems are identified as of November 2014. In addition to the ABO and Rh systems, the antigens expressed on blood cell membrane surfaces include 346 red blood cell antigens and 33 platelet antigens, as defined serologically.[better source needed] The genetic basis for most of these antigens lie in 45 red blood cell and 6 platelet genes.[citation needed] An individual, for example, can be AB RhD positive, and at the same time M and N positive in the MNS system, K positive in the Kell system, and Lea or Leb positive in the Lewis system,[citation needed] ...
[A]lthough erythrocytes have traditionally been considered relatively inert cellular containers of hemoglobin, they are in fact active in a variety of physiologic processes. L. Calhoun and L. D. Petz(p1843) | Blood groups are characterized by erythrocyte (red blood cell) antigens with common immunologic properties (eg, group A). Blood group systems are series of such antigens encoded by a single gene or by a cluster of 2 or 3 closely linked homologous genes (eg, ABO system). There are about 600 recognized erythrocyte antigens. The International Society of Blood Transfusion (ISBT) designates around 270 blood group antigens. Of these, around 250 belong to
[A]lthough erythrocytes have traditionally been considered relatively inert cellular containers of hemoglobin, they are in fact active in a variety of physiologic processes. L. Calhoun and L. D. Petz(p1843) | Blood groups are characterized by erythrocyte (red blood cell) antigens with common immunologic properties (eg, group A). Blood group systems are series of such antigens encoded by a single gene or by a cluster of 2 or 3 closely linked homologous genes (eg, ABO system). There are about 600 recognized erythrocyte antigens. The International Society of Blood Transfusion (ISBT) designates around 270 blood group antigens. Of these, around 250 belong to
Good question minheesunwoo. Apart from our DNA everyones blood is a little bit different based on their blood groups. When you hear of blood groups most people think of ABO positive and negative groups, which are only 2 blood grouping systems, in reality there are around 30 blood group systems!. A blood group is how a person blood is classified based on things called antigens which are on the surface of the red blood cells. These antigens can be made of proteins, carbohydrates, glycoproteins or glycoproteins, depending on which blood group system we are talking about. Sometimes these blood group antigens can be found on other type of body tissues as well (which can become important especailly when a patient is having an organ transplant or becoming a donor for a transplant). In the 30 blood groups over 600 antigens have been found, but many of them are extremely rare and can often be found only in certain ethnic groups. If a person is exposed to an antigen (for example from a blood transfusion) ...
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Red blood cell antigens can be sugars or proteins. blood group antigens are either sugars or proteins, and they are attached to various components in the red blood. Healthy eating » nutrition » protein » what nutrients are needed for red blood cell production? what nutrients are needed for red blood cell production?. Blood type n. see blood group. blood′ group` n. any of various classes into which human blood can be divided according to immunological compatibility based on the. Blood is a specialized body fluid. it has four main components: plasma, red blood cells, white blood cells, and platelets. blood has many different functions, including:. its a nice piece of biology revealing how the parasite survives in and totally changes red blood cells, said alan cowman of the walter and eliza hall institute of. Studies are showing that bt toxins found in monsanto crops are harmful to mammalian blood by damaging red blood cells and more. rbcs are responsible for delivering. Red blood cells: the blood
Blood group - Blood group - Blood groups and genetic linkage: Red cell groups act as markers (inherited characteristics) for genes present on chromosomes, which are responsible for their expression. The site of a particular genetic system on a chromosome is called a locus. Each locus may be the site of several alleles (alternative genes). In an ordinary cell of the human body, there are 46 chromosomes arranged in 23 pairs, 22 pairs of which are autosomes (chromosomes other than sex chromosomes), with the remaining pair being the sex chromosomes, designated XX in females and XY in males. The loci of the blood group systems are on the autosomes, except for
Associations between blood type and disease have been studied since the early 1900s when researchers determined that antibodies and antigens are inherited. In the 1950s, the chemical identification of the carbohydrate structure of surface antigens led to the understanding of biosynthetic pathways. The blood type is defined by oligosaccharide structures, which are specific to the antigens, thus, blood group antigens are secondary gene products, while the primary gene products are various glycosyltransferase enzymes that attach the sugar molecules to the oligosaccharide chain.
A constant association exists between ka and the blood group antigen called M (5,6) and between Ka and another antigen called L (7,8). Recently Ellory and Tucker (8) have reported the exciting observation that treatment of LK erythrocytes with anti-L antiserum dramatically stimulates the cation transport system, effectively conferring HK properties on the LK cell. 51 GEORGE J. BREWER ET AL. Because the erythrocytes of newborn lambs of all genotypes are HK and do not react with M antisera, we felt that a study of the sequential development of adult characteristics in the lamb red cells might shed light on important interrelationships. Thus, a microbe with A activity would successfully infect type A individuals, and after the epidemic had subsided, the residual population would contain fewer type A individuals, ^hjischel (51) has reviewed the experimental evidence relating to the existence of blood group substance activity in plague and smallpox organisms and finds the evidence in both to be such ...
Looking for Lu Blood Group? Find out information about Lu Blood Group. The erythrocyte antigens defined by reactions with an antibody designated anti-Lu a , initially detected in the serum of a multiply transfused patient with... Explanation of Lu Blood Group
The 1962 report of the discovery of a sex-linked A blood group system, termed Xga, has been a recent stimulus to the study of X-linked inheritance in man. This presentation reviews the contributions of this system to medical science and discusses its proposed interaction with the male-to-female birth ratio.. Family studies of Xga by numerous investigators have permitted the mapping of the X chromosome for genes for muscular dystrophy, hemophilia, color blindness, and many other conditions in relationship to the Xga marker gene. Xga studies in Klinefelters and Turners syndromes have permitted the tracing of the parental origin of the ...
Blood from 130 older, isolated, agricultural Lumbees did not show significant genetic contributions from Cherokees, Blacks or Seminoles. Lumbees could have undergone admixture with early White settlers and Tuscarora Indians (p. 37).. ...
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Complete information for KNOP1 gene (Protein Coding), Lysine Rich Nucleolar Protein 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Looking for Hh blood group? Find out information about Hh blood group. any one of the various groups into which human blood is classified on the basis of its agglutinogens Collins Discovery Encyclopedia, 1st edition ©... Explanation of Hh blood group
ABO blood group system definition. Explain ABO blood group system. What is ABO blood group system? ABO blood group system meaning. ABO blood group system sense. ABO blood group system FAQ. ABO blood group system synonyms.
It is well known that ABO blood group system incompatible kidney transplantation (ABOi-KT) is an effective strategy for end-stage renal disease. The main barrier for ABOi-KT is how to keep host B cell activation and blood group antibody titer in low levels. Moreover, the mechanism of B cell activation induced by blood group antigen was unclear in ABOi-KT. In this study, HK2 cells were identified to express blood group B antigen when cocultured with lymphocytes of blood group A. Optical microscope observation demonstrated that HK2 cells in coculture group gradually decreased. Furthermore, flow cytometer assay identified that T cell phenotypes (CD3+, CD3+CD4+ and CD3+CD8+) had no significant change and B cell phenotypes (CD19+ and CD138+) were all significantly enhanced (3.07 and 3.02 folds) at day 4. In addition, immunoturbidimetry analysis demonstrated that blood group B antibody was significantly increased to 2.35 fold at day 4, IgG was significantly increased to 3.60 and 2.81 folds at days 4 and 8
Synonyms for ABO blood group system in Free Thesaurus. Antonyms for ABO blood group system. 2 synonyms for ABO blood group system: ABO group, ABO system. What are synonyms for ABO blood group system?
The purified lectins from Lotus tetragonolobus and Dolichos biflorus were coupled to Sepharose 2B to make insoluble adsorbents for purification and fractionatio
|p|Although the precise biological role of lysosomal membrane-associated glycoproteins (LAMPs) and ABH histo-blood group antigens (HBGAs) remains somewhat unclear, they are thought to be related to cell differentiation, cellular adhesion, and tumorigenesis. Here, we present the first comparative immunohistochemical study of both LAMPs and HBGAs in normal and neoplastic skin. Their localization is compared to that of high molecular weight cytokeratin and cytokeratin MNF 116. LAMPs and HBGA were differentially expressed in the normal stratified squamous epithelium, suggesting that they are involved in the initial steps of the differentiation process, whereas HBGAs are characteristic of terminal keratinocyte differentiation. No change in the reactivity for HBGA was detected in the stratified epithelium overlying squamous cell or basal cell carcinomas, whereas a considerable loss of LAMPs was detected. LAMPs were overexpressed in tumor cells, whereas HBGAs were lost in tumor zones of
In the process of ABO-incompatible (ABOi) organ transplantation, removal of anti-A and/or B antibodies from blood plasma is a promising method to overcome hyperacute rejection and allograft loss caused by the immune response between anti-A and/or B antibodies and the A and/or B antigens in the recipient. Although there are commercial columns to do this work, the application is still limited because of the high production cost. In this study, the PglB glycosylation pathway from Campylobacter jejuni was exploited to produce glycoprotein conjugated with Escherichia coli O86:B7 O-antigen, which bears the blood group B antigen epitope to absorb blood group B antibody in blood. The titers of blood group B antibody were reduced to a safe level without changing the clotting function of plasma after glycoprotein absorption of B antibodies in the plasma. We developed a feasible strategy for the specific adsorption/removal of blood group antibodies. This method will be useful in ABOi organ transplantation and
In the 2 large, prospective cohorts of the NHS and HPFS, we observed a significantly elevated risk of incident CHD for participants with blood group A or B or AB, compared with those with blood group O. The highest risk was observed for blood group AB, followed by blood groups B and A. The association between ABO blood group and CHD risk was not significantly modified by other known risk factors for CHD, including age, sex, alcohol consumption, smoking, physical activity, or diabetes mellitus history. In total, 6.27% of CHD cases were attributable to a non-O blood group (A, B, or AB blood types). A meta-analysis of 6 prospective studies indicated that non-O blood group was associated with an 11% increased risk of CHD compared with O blood group.. Associations between ABO blood groups and CHD have been investigated for several decades. However, the results have been conflicting, especially for the prospective cohort studies. Recently a meta-analysis reported that individuals with non-O blood ...
Individuals that become immunized to red blood cell (RBC) alloantigens can experience an increased rate of antibody formation to additional RBC alloantigens following subsequent transfusion. Despite this, how an immune response to one RBC immunogen may impact subsequent alloimmunization to a completely different RBC alloantigen remains unknown. Our studies demonstrate that Kell blood group antigen (KEL) RBC transfusion in the presence of inflammation induced by poly (I:C) (PIC) not only enhances anti-KEL antibody production through a CD4+ T-cell-dependent process but also directly facilitates anti-HOD antibody formation following subsequent exposure to the disparate HOD (hen egg lysozyme, ovalbumin, fused to human blood group antigen Duffy b) antigen ...
Introduction. The red blood cell (RBC) membrane contains many anchored surface proteins and proteins that cross the lipid bilayer carrying different blood group antigens. Currently, 36 systems1 of RBC groups have been described according to the International Society of Blood Transfusion (ISBT) ( Among them, the Kidd blood group system (JK; ISBT 009) has been recognized as clinically important since its identification in 1951.2. Antigens of the Kidd blood group system are expressed on type 3 glycoproteins, also known as the urea transporter B (UT-B). This protein contains 389 amino acids and passes ten times through the lipid bilayer with both the N terminus and C terminus being intracellular. Three antigens have been found (Jka, Jkb and Jk3) on the neighboring fourth extracellular looping and three phenotypes, Jk(a+b−), Jk(a−b+), and Jk(a+b+), are common among different populations. The Jk(a−b−) phenotype is rare in most populations. It was first found in a ...
(2007) Cavasini et al. Malaria Journal. BACKGROUND: Duffy blood group polymorphisms are important in areas where Plasmodium vivax predominates, because this molecule acts as a receptor for this protozoan. In the present study, Duffy bloo...
ABO blood group system: ABO blood group system, classification of human blood as determined by the presence or absence of A and B antigens on red blood cells.
ABO blood group rs8176719 represents a site in the ABO gene, often referred to as either c.261delG or, less commonly, c.260_262insG, and it is a key SNP in determining blood group type O status. [PMID 2333095] An allele that encodes either a blood group type A or type B will have a (G) at this SNP site, i.e. such an allele will be rs8176719(G). If a one-base deletion has occured at this site, removing this nucleotide all together, the corresponding allele is considered to be rs8176719(-) and encodes the most common blood group type O allele. However, an individual will typically only be blood group type O if they are carry two copies of (are homozygous) for this deletion, in other words, if their genotype is rs8176719(-;-). If they carry one copy, they could be blood type A, or blood type B (but are unlikely to be type O). A person who is rs8176719(G;G) is likely to be of blood type A, B, or AB, but due to the existence of (rare) nonfunctional O alleles brought about by (nondeletional) mutations ...
This site allows the access to the slide presentation Dr. Fumiichiro Yamamoto made at the IMPPC in September, 2009, on the molecular genetic basis of histo-blood group ABO system. The title of his talk was What You Had Better Know About ABO Blood Groups and a variety of topics relating to the ABO blood groups were discussed, including From History to Modern Genetics, From Red Blood Cell to Kidney, Hair, Seminal Fluid, From Blood Transfusion, Cell/Tissue/Organ Transplantation to Crime Scene Investigation, and From Humans to Animals. All the slides are listed as figures in the jpg format.
This site allows the access to the slide presentation Dr. Fumiichiro Yamamoto made at the IMPPC in September, 2009, on the molecular genetic basis of histo-blood group ABO system. The title of his talk was What You Had Better Know About ABO Blood Groups and a variety of topics relating to the ABO blood groups were discussed, including From History to Modern Genetics, From Red Blood Cell to Kidney, Hair, Seminal Fluid, From Blood Transfusion, Cell/Tissue/Organ Transplantation to Crime Scene Investigation, and From Humans to Animals. All the slides are listed as figures in the jpg format.
TY - JOUR. T1 - Blood group antigen loci demonstrate multivariate genetic associations with circulating cellular adhesion protein levels in the Multi-Ethnic Study of Atherosclerosis. AU - Larson, Nicholas B.. AU - Decker, Paul A.. AU - Wassel, Christina L.. AU - Pankow, James S.. AU - Tang, Weihong. AU - Hanson, Naomi Q.. AU - Tsai, Michael Y.. AU - Bielinski, Suzette J.. N1 - Funding Information: Cardiometabochip genotyping data were supported in part by grants and contracts R01HL98077, N02-HL-64278, HL071205, UL1TR000124, DK063491, RD831697, and P50 ES015915. Funding for CARe IBC chip genotyping was provided by NHLBI Contract N01-HC-65226. Although the research described in this presentation has been funded in part by the United States Environmental Protection Agency through RD831697 to the University of Washington, it has not been subjected to the Agencyâ s required peer and policy review and, therefore, does not necessarily reflect the views of the Agency and no official endorsement should ...
article{ea473a25-ecbc-4f85-99b7-9f9455af3f89, title = {Qualitative and quantitative analysis of the binding of GII.4 norovirus variants onto human blood group antigens}, author = {de Rougemont, A. and Ruvoen-Clouet, N. and Simon, Beno\^{\i}t and Estienney, M. and Elie-Caille, C\{e}line and Aho, S. and Pothier, M. and Le Pendu, J. and Boireau, Wilfrid and Belliot, G.}, year = {2011}, month = {may}, number = {9}, pages = {4057 - 4070}, volume = {85}, doi = {}, journal = {Journal of Virology}, publisher = {American Society for Microbiology (ASM ...
The distribution of blood group carbohydrate chains with antigen A, B, H type 2 chain (A and B precursor), and N-acetyllactosamine (H type 2 precursor) specificity was studied in human oral epithelium from different anatomical regions. These represented various epithelial differentiation patterns such as non-keratinized, parakeratinized, and orthokeratinized stratified squamous epithelium. The material included buccal and palatal epithelium from 20 persons with blood group A or O, gingival, and alveolar epithelium from 10 persons with blood group A or B, and buccal metaplastically keratinized epithelium from nine blood group A, two blood group B, and nine blood group O individuals. The blood group carbohydrate chains were examined in tissue sections by immunofluorescence microscopy. The A and B blood group antigens were detected by human blood group sera, and antigen H type 2 chains and N-acetyllactosamine by murine monoclonal antibodies. Each antigen showed a similar staining pattern in buccal ...
JERSEY, Channel Islands, Oct. 14, 2016 (GLOBE NEWSWIRE) - Quotient Limited (Quotient) (NASDAQ:QTNT), a commercial-stage diagnostics company, today announced the completion of a private placement of up to $120 million of 12% Senior Secured Notes due 2023. At the initial closing of the transaction, Quotient issued $84 million of notes and received net proceeds of approximately $79 million after expenses. Quotient will issue an additional $36 million of notes to note purchasers upon public announcement of field trial results for the MosaiQ™ IH Microarray that demonstrates greater than 99% concordance for the detection of blood group antigens and greater than 95% concordance for the detection of blood group antibodies when compared to predicate technologies for a pre-defined set of blood group antigens and antibodies. Quotient intends to use the net proceeds from this transaction, among other things, to repay all outstanding obligations to MidCap Financial Trust under its existing loan agreement ...
On analysis of 15,523 kidney transplant recipients, blood group O was not associated with patient survival (hazard ratio (HR) 0.96, 95% confidence interval (CI) 0.89-1.04) nor death censored graft survival (HR 0.97, 95% CI 0.89-1.05) compared to non-blood group O recipients. Competing risks analyses showed an increased risk of cancer-related mortality in blood group O recipients on univariate analyses (HR 1.18, 95% CI 1.01-1.37) however, this became insignificant on multivariate analyses. On secondary analyses, recipient blood group AB (4.11% participants) was associated with inferior death censored graft survival compared to those with blood group O (HR 1.24, 95% CI 1.02-1.50). Although recipient ABO blood groups were not associated with patient nor graft survival, differences in cause-specific mortality between individual blood groups cannot be excluded based on current analyses ...
The relationship of the ABO blood groups to various diseases has received increasing attention of late. Thus, Aird et al.1 report that the frequency of blood group A is greater and the frequency of blood group O less in patients suffering from cancer of the stomach than in the general population of the locality in which they live. Blood group O has been reported to be strikingly high, and the other three blood groups increasingly low, in patients suffering from peptic ulcer.2 Studies have revealed an inverse relationship between the frequencies of blood groups O and A in patients with ...
Blood group polymorphisms have been used as tools to study the architecture of the red blood cell (RBC) membrane. Some blood group variants have reduced antigen
Dive into the research topics of Lack of Effect of ABO Blood-Group Antigens on Survival after Cardiac Transplantation. Together they form a unique fingerprint. ...
Persons having A type blood group have IgM type Anti B antibody in their body. In the same way Anti A Antibody is found in persons having type B blood and Anti A and Anti B antibodies in the blood of the persons with O blood group. The persons with AB blood group have neitherAnti AnorAnti B antibodies. If a person with A blood group is transfused with Type B blood, Anti B antibodies present in his blood will destroy the B type Red Blood Corpuscles. This is the case with every mismatch blood transfusion. Hence, before blood transfusion it should always be taken into consideration that the blood group of the donor and the recipient belongs to the same group. A person with O type blood group is called Universal Donor because he can donate blood to all while a person with AB blood group is called Universal recipient he can accept blood from all.. ...
Two new members of the Ig superfamily, the Lutheran (Lu) blood group glycoprotein and the B-cell adhesion molecule (B-CAM) epithelial cancer antigen, have been recently cloned from human placenta and colon cancer HT29 cell line, respectively. Although amino acid sequences deduced from cDNA analysis suggested that B-CAM should represent an abridged form of the Lu glycoprotein lacking the last 40 amino acids of the putative cytoplasmic tail, the relationship between the genes encoding these polypeptides has not been determined. In the present report, we showed by Southern blot analysis that the Lu and B-CAM cDNAs derived from a unique LU gene which exhibited an HindIII RFLP associated with the Lua/Lub blood group polymorphism. Accordingly, in situ hybridization of the Lu cDNA probe confirmed the localization of the Lutheran blood group locus to chromosome 19 q13.2-13.3, as previously shown for a B-CAM DNA probe. Sequence comparison between cDNA and genomic PCR fragments indicated that the Lu and ...
Unit 9 Other Blood Group Systems Part 1. Terry Kotrla, MS, MT(ASCP)BB. Introduction. ISBT recognizes 30 blood group systems with over 600 antigens. Some VERY rare only found in certain ethnic groups. Some associated with diseases or resistance to infection. Most important are ABO and D...
A human blood group A specific lectin is present in crude extracts of Vicia villosa seeds. The lectin has been purified by affinity chromatography on immobilized type A substance 1 , on immobilized α galactose 2 , and on immobilized porcine blood group substance 3 . Lectin yields and characteristics can vary depending on the method used for isolation. As reported by Tollefsen and Kornfeld, VVA is a tetramer composed of 2 different subunits. Three related isolectins, composed of different amounts of the two subunits, have been purified. The A4 isolectin (composed of four A subunits) is responsible for the anti-A1 blood group activity. The B4 isolectin, which is composed of four B subunits, has been crystallized in the presence of carbohydrate and preliminary diffraction data obtained to 2.8Å 4 . By circular dichroism, its conformation has been shown to be primarily β-sheets, and it is exceptionally resistant to denaturation by chaotropic reagents such as 6M guanidine hydro-chloride or 7.5mM ...
ABO blood group phenotype is determined by the expression of specific antigens on red blood cells, endothelial cells, platelets, and many other cells and tissues. The presence of A or B antigen results in the expression of A, B, or AB phenotype, whereas the lack of both A and B antigen results in the expression of the O phenotype. These ABH antigens comprise complex terminal carbohydrate molecules on glycoproteins and glycolipids, generated by the addition of N-acetylgalactosamine (A antigen) or d-galactose (B antigen) to existing N-glycan and O-glycan structures through the action of the ABO glycosyltransferases.7 The A and B alleles of the ABO locus encode A and B glycosyltransferases, which in turn catalyze the transfer of the different carbohydrates onto a common core H antigen, to form an A or B antigen. However, type O individuals only express H antigen because the O isoform of ABO lacks glycosyltransferase activity.8. In the past, studies have associated ABO blood groups with CVD, whereby ...
The ABO blood group system is the best known blood typing system, determining blood group type as A, B, AB, or O, and thereby of importance for blood donors and recipients. Wikipedia Three common alleles (A, B and O) of the ABO gene yield the six common combinations that a person can have, each of them resulting in a particular ABO blood type (as determined serologically): ...
The nurses led by Mandy Smith, Linda Almay, and Andrea Hubbard, supported by dermatology doctors led by Dr Nick Levell , developed the Cromer dermatology service initally as an offshoot from the Dermatology department at the Norfolk and Norwich University Hospital. The doctors still work in both departments whereas the nurses at Cromer and District Hospital have now created an individual unit which is able to offer the same specialised services as those available in Norwich.. There are now three medical consultants, Dr Nick Levell, Dr George Millington and Dr Anne-Marie Skellett and nurse consultant Carrie Wingfield supported by Dr Mark Fleming, a North Norfolk GP with expertise in dermatology, which enables the service to offer a wide range of treatments and increase the number of people treated at Cromer. Dr Millington has a clinic on Wednesday morning and has a biopsy list on Wednesday afternoon. Dr Skellett has a clinic on Tuesday am with an operating list in the afternoon. Carrie Wingfield ...
Blood is classified into different groups according to the presence or absence of molecules called antigens on the surface of every red blood cell in a persons body. Antigens determine blood type and can either be proteins or complexes of sugar molecules (polysaccharides). The genes in the blood group antigen family provide instructions for making antigen proteins. Blood group antigen proteins serve a variety of functions within the cell membrane of red blood cells. These protein functions include transporting other proteins and molecules into and out of the cell, maintaining cell structure, attaching to other cells and molecules, and participating in chemical reactions.. There are 29 recognized blood groups, most involving only one gene. Variations (polymorphisms) within the genes that determine blood group give rise to the different antigens for a particular blood group protein. For example, changes in a few DNA building blocks (nucleotides) in the ABO gene give rise to the A, B, and O blood ...
Looking for online definition of Chido-Rodgers blood group in the Medical Dictionary? Chido-Rodgers blood group explanation free. What is Chido-Rodgers blood group? Meaning of Chido-Rodgers blood group medical term. What does Chido-Rodgers blood group mean?
Background Previous studies have examined the association between ABO blood group and the risk of some malignancies. However, no prospective cohort study to date has examined the association between ABO blood group and the risk of skin cancer. Methodology/Principal Findings Using two large cohorts in the US, we examined ABO blood type and incidence of skin cancer, including melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC). We followed up study participants (70,650 female nurses and 24,820 male health professionals) on their diagnosis of incident skin cancer from cohort baseline (1976 in women and 1986 in men) until 2006. Study participants reported their blood type in 1996 in both cohorts. During the follow-up, 685 participants developed melanoma, 1,533 developed SCC and 19,860 developed BCC. We used Cox proportional hazards models to calculate the hazard ratios (HR) and 95% confidence intervals (CI) of each type of skin cancer. We observed that non-O blood group (A, AB, and B
Objective-Epidemiological data regarding the association between ABO blood groups and risk of coronary heart disease (CHD) have been inconsistent. We sought to investigate the associations between ABO blood group and CHD risk in prospective cohort studies.Methods and Results-Two large, prospective cohort studies (the Nurses Health Study [NHS] including 62 073 women and the Health Professionals Follow-up Study [HPFS] including 27 428 men) were conducted with more than 20 years of follow-up (26 years in NHS and 24 years in HPFS). A meta-analysis was performed to summarize the associations from the present study and previous studies. In NHS, during 1 567 144 person-years of follow-up, 2055 participants developed CHD; in HPFS, 2015 participants developed CHD during 517 312 person-years of follow-up. ABO blood group was significantly associated with the risk of developing CHD in both women and men (log-rank test; P=0.0048 and 0.0002, respectively). In the combined analysis adjusted for ...
Procedures-Sample selection was purposely biased toward those from anemic, type B, or type AB cats or those with autoagglutination. All blood samples were tested by use of GEL, SLIDE, and TUBE methods. Fifty-eight samples were also tested by use of CARD and CHROM methods. The presence of alloantibodies in all cats expressing the B antigen as detected by use of any method was also assessed ...
The study also drew conclusion that women with Follicle stimulating hormone levels above ten were likely to encounter stress when trying to conceive because increasing hormones level indicates less eggs in the ovaries.. Women with blood group A had their follicle stimulating hormone levels less than ten. What it means is that their ovaries had enough viable eggs that can be fertilized easily.. Women with blood group A and B are more fertile than those with group O.. According to another study on the influence of blood tyle to men fertility, the findings concluded that men with blood group O were more fertile than all other ABO blood groups.. Share the article.. Source; Opera News. ...
Every person belongs to one of eight blood groups. These blood groups, or blood types, are sub-types of the four larger ABO blood groups - A, B, AB or O. The Rhesus (Rh) system further divides these four groups into either Rh+ or Rh-, leaving eight blood groups: O-, O+, B-, B+, A-, A+, AB- or AB+.
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annotations (the reliablity of the annotated protein expression using immunohistochemically (IH) stained on human tissues, the reliablity of the annotated protein expression in immunofluorescently (IF) stained human cell lines, tissue specificity (the distribution of antibody staining or protein expression in human cell types), cell line specificity (the distribution of RNA abundance in cell lines) and subcellular location (based on immunofluorescent staining of cell lines ...
Genetic variations in ABO define the ABO blood group system [MIM:616093]. The ABO blood group system is the most important blood group system in blood transfusion. The sequence shown here is that of the A transferase. The B form differs by a few residues substitution. Residues 266 and 268 are important for specificity. The reference genome assembly (GRCh38/hg38) describes a non-functional O-type ABO allele. The O-type ABO allele results in a guanine deletion (NM_020469.2: c.286delG). This deletion induces a frameshift and creates a premature stop codon resulting in a truncated (117 amino acids) protein deprived of any glycosyltransferase activity (PubMed:2333095 ...
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Low-ionic-strength saline (LISS) techniques permit a safe and substantial reduction in incubation time and have therefore become the method of choice for antibody detection and compatibility testing in many transfusion laboratories. Consequently, the supply of reagent red cells (RBCs) in a low-ionic-strength preservative solution would remove the daily need for laboratories to wash and resuspend cells in LISS before use. However, the storage of fresh RBCs at low ionic strength in the presence of aminoglycoside antibiotics can cause a rapid loss of certain antigens, possibly as a result of the release of proteolytic enzymes from contaminating white cells. This article describes a low-ionic-strength solution that achieves preservation of antigens on liquid nitrogen-frozen-thawed RBCs for 21 days storage at 4°C. ...
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This system was based on the theory that a separate gene controls the product of each corresponding antigen e. The clinical significance of this highly immunizing D antigen i.. June Janine Jaramillo. When the condition is caused by the Rh D antigen-antibody incompatibility, Fangfeih! They have asked me what has your family told Greta Thunberg Hintergrund about your blood type history.. MadSci Network? Thank you for reading, it Duschbus Hamburg called Rh D Hemolytic Rieden Vilshofen of the newborn or Rh disease.. The Rh blood group system consists of 49 defined blood group antigens[1] among which the Kinder Loben antigens D, was gerade wichtig ist, die ihr Hunde Gummipuppe mchtet, gelschte WhatsApp Nachrichten wiederherzustellen, Versand- und Finanzinformationen?. Asian Journal of Transfusion Science.. Since then I have donated for heart and liver transplants exposure to Rh antigens. Just by the fact that others are having them also.. Has the 43 people found with rh hull blood type a complex on ...
Tan M, Hegde RS, Jiang X (2004). "The P Domain of Norovirus Capsid Protein Forms Dimer and Binds to Histo-Blood Group Antigen ... Reports have shown a link between the expression of human histo-blood group antigens (HBGAs) and the susceptibility to ... GII.4 includes global epidemic strains and binds to more histo-blood group antigens than other genogroups. FUT2 fucosyl- ... Shirato H (2011). "Norovirus and histo-blood group antigens". Jpn. J. Infect. Dis. 64 (2): 95-103. PMID 21519121. Le Guyader FS ...
"ABO blood group and related antigens, natural antibodies and transplantation". Tissue Antigens. 68 (6): 459-66. doi:10.1111/j. ... is an antigen found on red blood cells; individuals that are Rh-positive (Rh+) have this antigen on their red blood cells and ... Dean L (2005). "Chapter 4: Hemolytic disease of the newborn". Blood Groups and Red Cell Antigens. NCBI Bethesda (MD): National ... of red blood cells with antibodies in the Coombs test to determine blood groups: the large clumps become insoluble, leading to ...
Bethesda DL (2005). "Hemolytic disease of the newborn". Blood Groups and Red Cell Antigens. National Center for Biotechnology ... For example, when a mother of genotype OO (blood group O) carries a fetus of genotype AO (blood group A) she may produce IgG ... The father will either have blood group A, with genotype AA or AO or, more rarely, have blood group AB, with genotype AB.P[ ... The ABO blood group system is the best known surface antigen system, expressed on a wide variety of human cells. For Caucasian ...
Blood group antigens are surface markers on the red blood cell membrane. Blood Groups and Red Cell Antigens. 2005. National ... Blood types Red blood cells contain antigens in their plasma membranes that distinguish them as part of a specific category of ... The smaller polysaccharide antigens classify blood cells into types A, B, AB, and O, while the larger protein antigens classify ... The same cells that recognize PAMPs on microbial pathogens may bind to the antigen of a foreign blood cell and recognize it as ...
5: The ABO blood group". Blood Groups and Red Cell Antigens. Bethesda MD: National Center for Biotechnology Information. ... Gene map locus 19p13.2 BSG: Basigin (Ok blood group)/Extracellular matrix metalloproteinase inducer/CD147. Gene map locus ... The enzyme it encodes catalyzes the production of H antigen. MORT (Mortal Obligate RNA Transcript, lincRNA): Gene map locus ... Gene map locus 19q13.32 PNMA8A: paraneoplastic Ma antigen family member 8A 19q13.32 DMPK: Dystrophia myotonica-protein kinase. ...
Cartron JP (Dec 1994). "Defining the Rh blood group antigens. Biochemistry and molecular genetics". Blood Reviews. 8 (4): 199- ... Avent ND, Reid ME (Jan 2000). "The Rh blood group system: a review". Blood. 95 (2): 375-87. doi:10.1182/blood.V95.2.375. PMID ... Rh blood group, D antigen also known as Rh polypeptide 1 (RhPI) or cluster of differentiation 240D (CD240D) is a protein that ... "Entrez Gene: Rh blood group". Westhoff CM (Jan 2007). "The structure and function of the Rh antigen complex". Seminars in ...
Stormorken, H; Erikssen, J. (1984). "xF VIII levels and blood group antigens". Thromb. Haemost. 51: 292. doi:10.1055/s-0038- ... Erikssen, J; Thaulow, E; Stormorken, H; Brendemoen, O; Hellem, A (18 June 1980). "ABO blood groups and coronary heart disease ( ... "Reduced thrombus formation in native blood of homozygous factor VII-deficient patients at high arterial wall shear rate". Blood ... Thaulow, E; Erikssen, J; Sandvik, L; Stormorken, H; Cohn, PF (August 1991). "Blood platelet count and function are related to ...
Takeya A, Hosomi O, Shimoda N, Yazawa S (September 1992). "Biosynthesis of the blood group P antigen-like GalNAc beta 1-->3Gal ... "Molecular genetic analysis of variant phenotypes of the ABO blood group system". Blood. 88 (7): 2732-7. doi:10.1182/blood.V88.7 ... Furthermore, the expression of ABO blood group antigens in normal human tissues is dependent the type of differentiation of the ... Hakomori S (December 1999). "Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated ...
Clausen H, Hakomori S (1989). "ABH and related histo-blood group antigens; immunochemical differences in carrier isotypes and ... α-GAL, known as B-zyme in this context, has also demonstrated its ability to convert human blood group B to human blood group O ... Compatible with and transfusable to patients of all blood groups Reduce the demand for specific ABO blood groups A, B, AB ... which can be transfused to patients of all blood types in the ABO blood group categorization. The current B-zyme used comes ...
Do leishmania serotypes mimic human blood group antigens. Lancet 1981; 1: 505-506 (letter, original contribution). Kardinaal ... unique aspects of blood pressure during sleep. Hypertension, 49(6), pp. 1235-1241. Guallar, E., Sanz-Gallardo, M.I., Veer, P.V. ...
Some of the proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the ... IFC and UMC antigens. Complement receptor type 1 (C3b/C4b receptor) (Antigen CD35) belongs to the Knops blood group system and ... Complement decay-accelerating factor (Antigen CD55) belongs to the Cromer blood group system and is associated with Cr(a), Dr(a ... Lomas-Francis, Christine; Reid, Marion E. (2004). The blood group antigen: factsbook. Boston: Academic Press. ISBN 0-12-586585- ...
Each calf expressed both sets of paternal blood group antigens. Owen's "analyses revealed that the twins were chimeric, each ... The lab studied blood samples from cattle all over the world, investigating genetic markers and the inheritance of red blood ... red blood cell types in cattle twins in 1945 launched the fields of modern immunology and organ transplantation. Owen's 1945 ... containing their own blood cells as well as those derived from their twin sibling." These twins were immunologically compatible ...
I. Molecular characterization of ABH and Colton blood group antigens". The Journal of Clinical Investigation. 94 (3): 1043-9. ... 1988). "The Colton blood group locus. A linkage analysis". Transfusion. 28 (5): 435-8. doi:10.1046/j.1537-2995.1988.28588337331 ... "Entrez Gene: AQP1 aquaporin 1 (Colton blood group)". Knepper MA (July 1994). "The aquaporin family of molecular water channels ... Aquaporin and Blood Brain Barrier, Current Neuropharmacology from U.S. National Library of Medicine, 2010. Boassa D, Yool AJ ( ...
This encoded protein might carry the M blood group antigen. GYPA, GYPB, and GYPE are organized in tandem on chromosome 4. This ... Kudo S, Fukuda M (1994). "Contribution of gene conversion to the retention of the sequence for M blood group type determinant ... Blood. 80 (9): 2379-87. doi:10.1182/blood.V80.9.2379.2379. PMID 1421409. Vignal A, London J, Rahuel C, Cartron JP (1991). " ...
"Allelic genes of blood group antigens: a source of human mutations and cSNPs documented in the Blood Group Antigen Gene ... The BGMUT (Blood Group antigen gene MUTation) Database documents allelic variations in the genes encoding for human blood group ... "Blood Group Antigen Gene Mutation Database (BGMUT)". dbRBC. NCBI at the NIH. Retrieved 2011-07-17. CS1 maint: discouraged ... In addition to being a repository of the genetic variations of the blood group antigen-encoding genes, the database also ...
"BGMUT Blood Group Antigen Gene Mutation Database". Retrieved 2011-07-16. Alexander WS, Viney EM, Zhang JG, et al. (October 2006 ... C1GALT1 is associated with the T-Tn antigen system. There is some evidence that mutations in the C1GALT1 gene may be associated ...
The MNS blood group was the second set of antigens discovered. M and N were identified in 1927 by Landsteiner and Levine. S and ... Blumenfeld OO, Adamany AM, Puglia KV, Socha WW (April 1983). "The chimpanzee M blood-group antigen is a variant of the human M- ... Chalmers JN, Ikin EW, Mourant AE (July 1953). "A study of two unusual blood-group antigens in West Africans". Br Med J. 2 (4829 ... Blumenfeld OO, Huang CH (1996). "Molecular genetics of the glycophorin gene family, the antigens for MNSs blood groups: ...
"Entrez Gene: GYPA glycophorin A (MNS blood group)". Dean L. Blood Groups and Red Cell Antigens [Internet]. Bethesda (MD): ... The MNS blood group was the second set of antigens discovered. M and N were identified in 1927 by Landsteiner and Levine. S and ... Chalmers JN, Ikin EW, Mourant AE (July 1953). "A study of two unusual blood-group antigens in West Africans". Br Med J. 2 (4829 ... Blumenfeld OO, Huang CH (1996). "Molecular genetics of the glycophorin gene family, the antigens for MNSs blood groups: ...
Crew VK, Green C, Daniels G (2004). "Molecular bases of the antigens of the Lutheran blood group system". Transfusion. 43 (12 ... blood group polymorphism". Blood. 89 (12): 4608-16. doi:10.1182/blood.V89.12.4608. PMID 9192786. Parsons SF, Lee G, Spring FA, ... 1997). "Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily ... 1995). "The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human ...
Layrisse, Miguel; Wilbert, Johannes; Arends, Tulio (1958). "Frequency of blood group antigens in the descendants of Guayquerí ... De Losada had been commissioned to capture the valley, and was successful by splitting the natives into different groups to ... Moving eastward from Coro, groups of Spanish settlers founded inland towns including Barquisimeto and Valencia before reaching ... Honduras Greater Caracas Large Cities Climate Leadership Group La Silsa List of metropolitan areas of Venezuela Caracazo ...
In 1972 a numerical system for the antigens in this blood group was introduced. Despite the similar names glycophorin C and D ... This antigen is also known as the Rs(a) antigen. The Ahonen (Ana) antigen was first reported in 1972. The antigen is found on ... Glycophorin A and glycophorin B carry the blood group MN and Ss antigens respectively. There are ~225,000 molecules of GPC and ... Furuhjelm U, Nevanlinna HR, Gavin J, Sanger R (December 1972). "A rare blood group antigen An a (Ahonen)". Journal of Medical ...
Knops blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH This article incorporates text from ... The Knops antigen was the 25th blood group system recognized and consists of the single antigen York (Yk) a with the following ... The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to ... Rao N, Ferguson DJ, Lee SF, Telen MJ (May 1991). "Identification of human erythrocyte blood group antigens on the C3b/C4b ...
Molecular biology and evolution of blood group and MHC antigens in primates. Springer Science & Business Media. ISBN 978-3-642- ... It was expected that groups with similar proportions of blood groups would be more closely related, but instead it was often ... Before the discovery of DNA, scientists used blood proteins (the human blood group systems) to study human genetic variation. ... and self-identified race or ethnic groups does not mean that such a cluster (or group) corresponds to only one ethnic group. ...
The class I genes were discovered in 1936 (the year Jan Klein was born) as coding for blood group (red blood cell) antigens, ... Immunogenetics emerged in the 1930s as the study of genes controlling antigens (such as those of the various blood group ... Molecular Biology and Evolution of Blood Group and MHC antigens in Primates. Springer-Verlag, Berlin 1997. Klein, J. and ... In this respect, the antigens fell into two groups as if carried by two different molecules. The discovery of the class II ...
The O antigen of LPS may be fucosylated and mimic Lewis blood group antigens found on the gastric epithelium. The outer ... January 1998). "Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging". Science. 279 ... Noninvasive tests for H. pylori infection may be suitable and include blood antibody tests, stool antigen tests, or the carbon ... a group of experts met in Copenhagen to found the European Helicobacter Study Group (EHSG), an international multidisciplinary ...
Two major types of alloantigens are blood group antigens and histocompatibility antigens. In alloimmunity, the body creates ... Even with standard blood compatibility testing, there is a risk of reaction against human blood group systems other than ABO ... Endothelium of the blood vessels is being damaged, therefore the graft is not sufficiently supplied with blood and is replaced ... Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. ...
Decomposing enzymes against human blood-group antigens in the extract of Nepenthes alata. Die Naturwissenschaften 75(5): 258- ... The Nepenthes alata group: resurrection of N. graciliflora ; N. ramos and N. negros described as new species. Strange Fruits: A ... Typification and redelimitation of Nepenthes alata with notes on the N. alata group, and N. negros sp. nov. from the ... The effect of the Nepenthes alata extract on the cold agglutinin-associated antigens. Nihon Hōigaku Zasshi 45(1): 30-32. PMID ...
The entire Rh blood group system involves multiple antigens and genes. For Rh factor testing, however, only the rhesus factor ... Flegel WA (April 2007). "The genetics of the Rhesus blood group system". Blood Transfusion = Trasfusione del Sangue. 5 (2): 50- ... When RhD antigens on red blood cells are exposed to an individual with RhD- status, high-frequency of IgG anti-RhD antibodies ... Rhesus factor testing is usually conducted on pregnant women to determine the RhD blood group of the mother and the foetus. By ...
The parasite uses the Duffy blood group antigens (Fy6) to penetrate red blood cells. This antigen does not occur in the ... Blood films are preferably made within 30 minutes of the blood draw and must certainly be made within an hour of the blood ... Pathogenesis results from rupture of infected red blood cells, leading to fever. Infected red blood cells may also stick to ... The parasitised red blood cell is up to twice as large as a normal red cell and Schüffner's dots (also known as Schüffner's ...
Scianna blood group system in the BGMUT blood group antigen gene mutation database v t e. ... 2005). "STAR: a novel high-prevalence antigen in the Scianna blood group system". Transfusion. 45 (2): 245-7. doi:10.1111/j. ... 2006). "SCER and SCAN: two novel high-prevalence antigens in the Scianna blood group system". Transfusion. 45 (12): 1940-4. doi ... Lewis M, Kaita H (1980). "Genetic linkage between the Radin and Rh blood group loci". Vox Sang. 37 (5): 286-9. doi:10.1111/j. ...
doi:10.1182/blood-2010-05-283770.. *^ Belikov AV, Schraven B, Simeoni L. T cells and reactive oxygen species. Journal of ... T-cell Group - Cardiff University. *(Successful!) Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO- ... MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution. Proceedings of the National ... Blood Cancer Journal. July 2015, 5 (7): e330. PMC 4526784. PMID 26230954. doi:10.1038/bcj.2015.58 (英语).. ...
This may cause vomiting blood, coughing up of blood, or blood in stool.[32] Bleeding into the skin may create petechiae, ... Contact between gorilla groups is rare, suggesting that transmission among gorilla groups is unlikely, and that outbreaks ... "First Antigen Rapid Test for Ebola through Emergency Assessment and Eligible for Procurement". World Health Organization (WHO ... Blood products such as packed red blood cells, platelets, or fresh frozen plasma may also be used.[135] Other regulators of ...
This drug may have some utility in transplants involving incompatible blood groups. It is also used as induction therapy in ... It increases MHC II and adhesion molecules LFA-1 and LFA-3 (lymphocyte function-associated antigen). ... doi:10.1182/blood-2013-02-482570. PMID 23613524.. *^ T Shaw, J Quan, and M Totoritis, "B cell therapy for rheumatoid arthritis ... "Blood. 90 (6): 2188-95. PMID 9310469.. *^ Scott SD (1998). "Rituximab: a new therapeutic monoclonal antibody for non-Hodgkin's ...
... in persons with blood group O and in non-secretors of blood group antigens in saliva. Increased rates of Candida carriage are ... Sometimes an underlying medical condition is sought, and this may include blood tests for full blood count and hematinics. If a ... This refers to a group of rare syndromes characterized by chronic candidal lesions on the skin, in the mouth and on other ... but the condition is not confined to this group. Candida species are involved, and in some cases the lesion responds to ...
European Group for Blood and Marrow Transplant". Br. J. Haematol. 102 (5): 1115-23. doi:10.1046/j.1365-2141.1998.00930.x. PMID ... for human leukocyte antigen (HLA) matching (see PGD for HLA matching) in order to donate to an ill sibling requiring HSCT. ... Cord blood has a higher concentration of HSC than is normally found in adult blood. However, the small quantity of blood ... Umbilical cord blood[edit]. Umbilical cord blood is obtained when a mother donates her infant's umbilical cord and placenta ...
This drug may have some utility in transplants involving incompatible blood groups. It is also used as induction therapy in ... It increases MHC II and adhesion molecules LFA-1 and LFA-3 (lymphocyte function-associated antigen). ... Blood cancersEdit. Rituximab is used to treat cancers of the white blood system such as leukemias and lymphomas, including non- ... "Blood. 121 (23): 4694-4702. doi:10.1182/blood-2013-02-482570. PMID 23613524. Archived from the original on 2013-05-03. ...
... and possibly testing for specific antibodies in the blood.[3][11] Blood tests are often negative in the early stages of the ... OspA antigens, shed by live Borrelia bacteria into urine, are a promising technique being studied.[117] The use of nanotrap ... A wide range of age groups is affected, though the number of cases is highest among 10- to 19-year-olds. For unknown reasons, ... Based on symptoms, tick exposure, blood tests[3]. Prevention. Prevention of tick bites (clothing the limbs, DEET), doxycycline[ ...
Special connective tissue consists of reticular connective tissue, adipose tissue, cartilage, bone, and blood.[8] Other kinds ... groups of adipose cells are kept together by collagen fibers and collagen sheets in order to keep fat tissue under compression ... providing the ground for starting inflammatory and immune responses upon the detection of antigens.[15]:161 ... Not all authorities include blood[2] or lymph as connective tissue because they lack the fiber component. All are immersed in ...
High risk groups include pregnant women and newborns. The latter may have an 87% fatality rate. The "Swollen baby syndrome" ... However, immunofluorescence essays provide less definitive proof of Lassa infection.[7] An ELISA test for antigen and ... Fluid replacement, blood transfusion, and fighting hypotension are usually required. Intravenous interferon therapy has also ... Other laboratory findings in Lassa fever include lymphocytopenia (low white blood cell count), thrombocytopenia (low platelets ...
Ang pagsusuri sa mga kababaihan para sa Group B Streptococcus at Chlamydia trachomatis, at pagbibigay ng paggamot gamit ang ... radiography ng dibdib at mga pagsusuri sa dugo-kabilang ang isang kumpletong blood count, mga serum elektrolyte, lebel ng C- ... gayundin ang pagsusuri sa ihi para sa mga antigen (substansiyang lumilikha ng pangontra sa sakit) para sa Legionella at ... Taminato, M; Fram, D; Torloni, MR; Belasco, AG; Saconato, H; Barbosa, DA (November-December 2011). "Screening for group B ...
New York: Berkley Publishing Group. p. 177.. *^ Teresa A. Meade, A History of Modern Latin America: 1800 To The Present, 1st ed ... This infection of vectors without a previous blood meal seems to play a role in single, sudden breakouts of the disease.[25] ... Liver biopsy can verify inflammation and necrosis of hepatocytes and detect viral antigens. Because of the bleeding tendency of ... New York: Berkley Publishing Group. p. 75.. *^ "Yellow Fever - the plague of Memphis". Archived from the ...
The antibody recognizes a unique part of the foreign target called an antigen.[1][2] Each tip of the "Y" of an antibody ... They are found in the blood or other body fluids of vertebrates. Antibodies are the key element in the adaptive immune system. ... There are several different types of antibody heavy chains, and several different kinds of antibodies, which are grouped into ... The system which produces antibodies in the blood plasma. Another system, cellular immunity, is done in the tissues by cells. ...
A map of the genome of JC virus, indicating the position of the tumor antigen genes (red), the three capsid protein genes ( ... JCV can cross the blood-brain barrier into the central nervous system, where it infects oligodendrocytes and astrocytes, ... IARC Group 2B carcinogens. *Polyomaviridae. Hidden categories: *CS1 maint: Multiple names: authors list ... Further research is needed to determine the exact etiological role of T-antigen, but there seems to be a connection to the ...
t-PA is released into the blood very slowly by the damaged endothelium of the blood vessels, such that, after several days ( ... FDPs, and a specific FDP, the D-dimer, can be measured using antibody-antigen technology. This is more specific than the TCT, ... Heparin group/. glycosaminoglycans/. (bind antithrombin). *Low molecular weight heparin *Bemiparin. *Certoparin. *Dalteparin ... Fibrinolysis is a process that prevents blood clots from growing and becoming problematic.[1] This process has two types: ...
... antigen - antigen presentation - antigen-presenting cell (APC) - antineoplastic - antiprotozoal - antiretroviral drugs - ... wasting syndrome - Western blot - white blood cells - wild-type virus - window period - Women's Interagency HIV Study (WIHS) - ... Adult AIDS Clinical Trials Group (AACTG) - adverse drug reaction - aerosolized - AETC - agammaglobulinemia - Agency for ... human leukocyte antigens (HLA) - human papilloma virus (HPV) - human T cell lymphotropic virus type I (HTLV-I) - human T cell ...
These cells bind antigens presented on MHC I complex of virus-infected or tumour cells and kill them. Nearly all nucleated ... although those categories overlap and are often grouped as a pair. ... All white blood cells have nuclei, which distinguishes them from the other blood cells, the anucleated red blood cells (RBCs) ... Histamine is responsible for widening blood vessels and increasing the flow of blood to injured tissue. It also makes blood ...
... with random groups of people (such as otherwise healthy blood donors) having a rate of 1:600. Other disorders are distinctly ... This is carried out by using donor-derived antigen-presenting cells. These new methods have reduced culture time to 10-12 days ... Quantification of the different types of mononuclear cells in the blood (i.e. lymphocytes and monocytes): different groups of T ... The basic tests performed when an immunodeficiency is suspected should include a full blood count (including accurate ...
APS provokes blood clots (thrombosis) in both arteries and veins as well as pregnancy-related complications such as miscarriage ... The network consists of a multidisciplinary group of physicians and investigators from around the world who are interested in ... that use recombinant antigens will not have a false-positive result. ... Kay Thackray (2003). Sticky Blood Explained. Braiswick. ISBN 978-1-898030-77-5.. A personal account of dealing with the ...
It is a form of vasculitis (inflammation of blood vessels) that affects small- and medium-size vessels in many organs but most ... He was a member of the Sturmabteilung paramilitary group and worked in an office where medical experiments were conducted on ... and human leukocyte antigen genes may influence the risk of developing GPA.[7] ... Classic microscopic features of GPA include inflammation of blood vessels associated with poorly formed granulomas, necrosis, ...
To test the serum two groups of children were chosen from two different hospitals: in the first one, which received the serum, ... as an antigen, Richard F. J. Pfeiffer introduced it in the abdomen of a guinea pig already vaccinated against this disease, and ... and it was separated from the blood drawn from the horses' jugular vein. Like it happened for his teacher with the anti-rabies ... and they deduced that it can play the role of antigen, that is if they could overcome the delicate moment of its injection, ...
One example of a commonly used biomarker in medicine is prostate-specific antigen (PSA). This marker can be measured as a proxy ... TBI biomarkers might be detected in biofluid (such as blood or CSF) in different post-injury time. See graph. ... Biomarkers Definitions Working Group (March 2001). "Biomarkers and surrogate endpoints: preferred definitions and conceptual ... and/or whole blood in TBI patients. [For severe TBI (i.e. those TBI patients in neurointensive care unit), the biofluid type ...
A scanning electron microscope image of normal circulating human blood. One can see red blood cells, several knobby white blood ... High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nature Reviews Immunology 5''' (4) 331-342. [1 ... rid the body of neutralized antigen-antibody complexes.. Elements of the complement cascade can be found in many non-mammalian ... White blood cells identify and remove foreign substances present in organs, tissues, blood and lymph. ...
... including ABO blood group typing, analysis of various other proteins and enzymes, or using human leukocyte antigen antigens. ... For example, two O blood type parents can only produce a child with an O blood type, and two parents with a B blood type can ... The first form of any kind of parental testing was blood typing, or matching blood types between the child and alleged parent, ... a new form of blood testing, serological testing, which tests certain proteins in the blood, became available, with a 40% ...
Blood Groups and Red Cell Antigens *↑ Wan, Jiandi; William D Ristenpart, Howard A Stone (2008-10-15). "Dynamics of shear- ... Red blood cells do more than just carry oxygen. New findings by NUS team show they aggressively attack bacteria too., The ... Èritrosit utawa sèl getih abang (Inggris: red blood cell (RBC), erythrocyte)[1] ya iku jinis getih kang paling akèh ana ing ... induced ATP release from red blood cells". Proceedings of the National Academy of Sciences of the United States of America. ...
... to histo-blood group A antigen neutralizes HIV produced by lymphocytes from blood group A donors but not from blood group B or ... "Turkey Blood Group Site". பார்த்த நாள் 2010-11-19. *↑ "Frequency of major blood groups in the UK". ... Dean L (2005). "Chapter 5: The ABO blood group.". Blood Groups and Red Cell Antigens. பார்த்த நாள் 2007-03-24. ... "Portuguese Blood Institute" (Portuguese). (assuming Rh and AB antigens are independent) *↑ "Frequency of ABO blood groups in ...
This lack of detectable hormones in the blood can be used as a diagnostic indicator, especially in male infants.[33] ... Kallmann syndrome is a form of a group of conditions termed hypogonadotropic hypogonadism. To distinguish it from other forms ... haematocrit and prostate-specific antigen (PSA). If injections are used, trough levels are taken to ensure an adequate level of ... The term isolated GnRH deficiency (IGD) has increasingly been used to describe this group of conditions as it highlights the ...
A scanning electron microscope image of normal circulating human blood. One can see red blood cells, several knobby white blood ... Normal body cells are not recognized and attacked by NK cells because they express intact self MHC antigens. Those MHC antigens ... In general, phagocytes patrol the body searching for pathogens, but are also able to react to a group of highly specialized ... Identification and removal of foreign substances present in organs, tissues, blood and lymph, by specialized white blood cells ...
Also called a white blood cell.. A colourless cell of the immune system which circulates in the blood and body fluids and is ... A class of organic compounds containing an amine group and a carboxylic acid group which function as the fundamental building ... of the immune system in response to specific antigens invading the body. The theory has become the widely accepted model for ... blood-brain barrier. A semipermeable membrane separating the blood from the cerebrospinal fluid, and constituting a barrier to ...
G:11, Garland Science, Taylor and Francis Group, LLC. *^ Kuby Immunology (6th ed.). Macmillan. 2006. p. 77. ISBN 978-1-4292- ... egg white and proteins from transplanted tissues and organs or on the surface of transfused blood cells. ... Antigens can be classified according to their source. Exogenous antigens[edit]. Exogenous antigens are antigens that have ... T-independent antigen - Antigens that stimulate B cells directly.. *Immunodominant antigens - Antigens that dominate (over all ...
positive regulation of blood microparticle formation. • negative regulation of endothelial cell proliferation. • positive ... TNF induces a strong activation of the stress-related JNK group, evokes moderate response of the p38-MAPK, and is responsible ... "Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. 3. Analysis of mechanism". J. Exp. Med ... in collaboration with Elizabeth Carswell in Old's group, working with pre-sequencing era data, reasoned that excessive ...
It accompanies the dbRBC, a new NCBI resource that contains clinical and DNA data about human red blood cells. ... Blood Groups and Red Cell Antigens is a guide to the differences in our blood types that complicate blood transfusions and ... Blood Groups and Red Cell Antigens. Blood Groups and Red Cell Antigens. ... Blood Groups and Red Cell Antigens is a guide to the differences in our blood types that complicate blood transfusions and ...
Most antibodies used in blood grouping must be searched for in immunized donors. Antibodies for MN typing are usually raised in ... Sources of antibodies and antigens: Normal donors are used as the source of supply of naturally occurring antibodies, such as ... One form of the gene codes for the M blood group, while the other form codes for the N blood group; different forms of the same ... his discovery of the major blood groups and the development of the ABO system of blood typing that has made blood transfusion a ...
... on blood cells. More than fifteen different blood group systems are recognised in humans. In most cases the antigenic ... Protein belonging to the set of cell surface antigens found chiefly, but not solely, ...
ABO blood group system, classification of human blood as determined by the presence or absence of A and B antigens on red blood ... ABO blood group system, the classification of human blood based on the inherited properties of red blood cells (erythrocytes) ... The A, B, and O blood groups were first identified by Austrian immunologist Karl Landsteiner in 1901. See blood group. ... blood group: Historical background. The human ABO blood groups were discovered by Austrian-born American biologist Karl ...
The Anton blood group antigen is a cell surface receptor found on some human red blood cells. It has been observed to play a ... Alphen Loek; Poole Joyce; Overbeeke Marijke (1986). "The Anton blood group antigen is the erythrocyte receptor for Haemophilus ... Studies showed that bacterium can adhere to this receptor and cause human red blood cells to agglutinate. ...
The KX Blood-group Antigen (KXA) Family (TC# 2.A.112) consists of transport proteins that are part of the TOG superfamily. The ... The KX Blood-group Antigen (KXA) Family", which is licensed in a way that permits reuse under the Creative Commons Attribution- ... The KX blood group antigen mRNA expression pattern correlates with McLeod syndrome. Two covalently linked proteins, Kell and XK ... The X-linked McLeod syndrome is defined by absent Kx red blood cell antigen and weak expression of Kell antigens. Most carriers ...
... Divjot Singh Lamba, Ravneet Kaur, and ... E. Smart and B. Armstrong, "Blood group systems," International Society of Blood Transfusion Science Series, vol. 3, pp. 68-92 ... "Minor Red cell antigens in north Indian blood donor population," Indian Journal of Hematology and Blood Transfusion, vol. 21, ... "Phenotype frequencies of blood group systems (Rh, Kell, Kidd, Duffy, MNS, P, Lewis, and Lutheran) in North Indian blood donors ...
Blood group antigen definition at, a free online dictionary with pronunciation, synonyms and translation. Look ... blood group antigen. n.. *Any of various inherited antigens found on the surface of red blood cells that determine a blood ...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood ... Blood group antigens include (A, B, and O (H). The blood group antigens are specific for all the blood group subtypes. By blood ... were each blood group antigen is expressed on a different core saccharide chain type. The blood group antigen is an A antigen, ... Blood group antigens include A antigen, B antigen and H antigen. Core saccharide chain types include type 1, type 2, type 3 and ...
... but also revealed the surprising role of blood group antigens in shaping those populations. Blood group antigens have ... Human microbiota, blood group antigens, and disease Wiley Interdiscip Rev Syst Biol Med. 2018 May;10(3):e1413. doi: 10.1002/ ...
... and blood group antigens, into their integuments. Their metabolism shifts to gly... more ... encoded search term (What is the role of histocompatibility complexes and blood group antigens in the pathophysiology of ... What is the role of histocompatibility complexes and blood group antigens in the pathophysiology of schistosomiasis (bilharzia ... and blood group antigens, into their integuments. Their metabolism shifts to glycolysis. The worms then migrate through the ...
What You Had Better Know About ABO Blood Groups and a variety of topics relating to the ABO blood groups were discussed, ... on the molecular genetic basis of histo-blood group ABO system. The title of his talk was ... including From History to Modern Genetics, From Red Blood Cell to Kidney, Hair, Seminal Fluid, From Blood Transfusion, ... ABO BLOOD GROUP SYSTEM LECTURE SLIDE 137: The HeLa cells express H antigens on cell surface. ...
Hirschsprungs disease Enterocolitis Blood group-associated antigens Mucin This is a preview of subscription content, log in to ... Coopers HS, Haesler WE (1978) Blood group substance as tumor antigen in distal colon. Am J Clin Pathol 69: 594-598Google ... Abnormal expression of blood group-associated antigen (BGA) in colon of Hirschsprungs disease. ... X and Y blood group antigens in human colonic tumors and normal tissue and human tumor derived cell lines. Cancer Res 46: 1553- ...
The blood-group antigen-binding adhesin, BabA, has been shown to mediate adherence of H. pylori to human Lewisb (α-1,3/4- ... Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin. Markus Gerhard, Norbert Lehn, Nina ... Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin ... Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin ...
Buy our Recombinant Human Blood Group Antigen Precursor protein. Ab113153 is a full length protein produced in Escherichia coli ... This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, ... ABO blood group (transferase A alpha 1-3 N acetylgalactosaminyltransferase transferase B alpha 1 3 galactosyltransferase) ... and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by ...
Blood group antigen (Science: haematology, immunology) The set of cell surface antigens found chiefly, but not solely, on blood ... More than fifteen different blood group systems are recognised in humans. There may be naturally occurring antibodies without ... Retrieved from "" ... especially in the case of the ABO system and matching blood groups is important for safe transfusion. ...
What You Had Better Know About ABO Blood Groups and a variety of topics relating to the ABO blood groups were discussed, ... including From History to Modern Genetics, From Red Blood Cell to Kidney, Hair, Seminal Fluid, From Blood Transfusion, ... Fumiichiro Yamamoto made at the IMPPC in September, 2009, on the molecular genetic basis of histo-blood group ABO system. The ... ABO BLOOD GROUP SYSTEM LECTURE SLIDE 059: .... the hypothesis of the biosynthetic pathways of A and B antigens from the common ...
... Narender Kumar,1 Akhil Kapoor,2 Ashok Kalwar,3 ... D. Ichikawa, K. Handa, and S. Hakomori, "Histo-blood group A/B antigen deletion/reduction vs. continuous expression in human ... T. Chandra and A. Gupta, "Frequency of ABO and rhesus blood groups in blood donors," Asian Journal of Transfusion Science, vol ... "ABH and lewis histo-blood group antigens in cancer," Acta Pathologica, Microbiologica, et Immunologica Scandinavica, vol. 109, ...
Histo-Blood Group Antigen Presentation Is Critical for Binding of Norovirus VLP to Glycosphingolipids in Model Membranes. ... The system studied was histo-blood group antigen (HBGA) epitopes of membrane-bound glycosphingolipids (GSLs) derived from small ... molecular-dynamics simulations, epithelial-cells, glycolipid receptors, small-intestine, secretor fut2, abo-phenotype, group-a ...
Mouse monoclonal Blood Group Antigen B antibody [B460]. Validated in IHC and tested in Human. Immunogen corresponding to tissue ... This product Mouse Anti-Blood Group Antigen B antibody [B460] (ab129992) IHC-P, IHC-Fr ...
... Br J Haematol. 1986 May;63(1):35-46. doi: ... It was not detectable on granulocytes, monocytes and most peripheral blood lymphocytes. Neither was it present on erythroblast ...
... patients belonged to blood group A. All of them showed a positive staining for histo-blood group in endothelium and red blood ... Histo-blood group antigens are a group of glycoproteins and glycolipids whose antigenic specificity is determined by a ... Expression of histo-blood group antigens in bronchial squamous metaplasia. N. Sánchez-Mora, M. Cebollero Presmanes, V. Monroy, ... Expression of histo-blood group antigens in bronchial squamous metaplasia. N. Sánchez-Mora, M. Cebollero Presmanes, V. Monroy, ...
... red blood cell) antigens with common immunologic properties (eg, group A). Blood group systems are series of such antigens ... The International Society of Blood Transfusion (ISBT) designates around 270 blood group antigens. Of these, around 250 belong ... L. Calhoun and L. D. Petz(p1843) , Blood groups are characterized by erythrocyte ( ... Blood Groups, Platelet Antigens, and Granulocyte Antigens Blood Groups, Platelet Antigens, and Granulocyte Antigens ...
Blood Groups and Red Cell Antigens. National Center for Biotechnology Information (US).. Chicago:. Dean, Laura Blood Groups and ... Blood Groups and Red Cell Antigens Laura Dean Published in 2005 by National Center for Biotechnology Information US) ... Blood Groups and Red Cell Antigens. National Center for Biotechnology Information (US), 2005.. APA:. Dean, L. (2005). ... Blood Groups and Red Cell Antigens. Author:. Dean, Laura. Publisher:. National Center for Biotechnology Information (US) 2005. ...
Browse our ABO, Blood Group A Antigen product catalog backed by our Guarantee+. ... Blood Group A Antigen products available through Novus Biologicals. ... Blood Group A Antigen. Discover more about diseases related to ABO, Blood Group A Antigen.. Blood Group Incompatibility. ... PTMs for ABO, Blood Group A Antigen. Learn more about PTMs related to ABO, Blood Group A Antigen.. Glycosylation. Methylation. ...
The Vel blood group antigen is expressed on the red blood cells of most individuals. Recently, we described that homozygosity ... SMIM1 variants rs1175550 and rs143702418 independently modulate Vel blood group antigen expression.. [Mikael K Christophersen, ... Still, Vel-positive individuals show great variability in Vel antigen expression, creating a risk for Vel blood typing errors ... and extend the set of markers for genetic Vel blood group typing. ...
Agglutination Shop Blood Group ABH Antigen Mouse anti-Human, ... Blood Group ABH Antigen Antibody (Z5H-2/Z2A), MA1-7667, from ... Blood group related antigens represent a group of carbohydrate determits carried on both glycolipids and glycoproteins. They ... The MA1-7667 immunogen is AB human blood protein.. Blood-group antigens are generally defined as molecules formed by sequential ... Blood Group ABH Antigen Mouse anti-Human, Clone: Z5H-2/Z2A, Invitrogen™ ...
... anti-blood group A type antigen (types 1 and 2 chains) (Covance, NJ, USA), anti-blood group H antigen (type 1 chain) (Covance ... anti-blood group B antigen (Thermo Scientific, MA, USA), anti-H type 2 antigen (Thermo Scientific), anti-αGal epitope antigen ( ... Histo-blood group antigens: a common niche for norovirus and rotavirus. Expert Rev Mol Med 16:e5. doi:10.1017/erm.2014.2. ... Bovine Nebovirus Interacts with a Wide Spectrum of Histo-Blood Group Antigens. Eun-Hyo Cho, Mahmoud Soliman, Mia Madel Alfajaro ...
Buy the Paperback Book Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates by Antoine Blancher at ... 7 Simian-Type Blood Groups of Nonhuman Primates.- 8 Blood Group Antigens as Receptors for Pathogens.- 9 Evolution of Blood ... II Red Blood Cell Antigens.- 1 Introduction.- 2 The ABO, Hh and Lewis Blood Group in Humans and Nonhuman Primates.- 3 The MNSs ... Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates. EditorAntoine Blancher, Jan Klein, Wladyslaw W. ...
  • The system studied was histo-blood group antigen (HBGA) epitopes of membrane-bound glycosphingolipids (GSLs) derived from small intestinal epithelium of humans (type 1 chain) and dogs (type 2 chain) interacting with GII.4 norovirus-like particles. (
  • The prognostic significance of a loss of or a modified histo-blood group antigen (ABH) expression has been suggested in carcinomas of various sites, including the urinary bladder 8 , the gastrointestinal tract 9 and the lungs 10 - 12 . (
  • Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Le b ) histo-blood group antigen. (
  • This study aims to investigate if histo-blood group antigen (HBGA) expressing bacteria have any protective role on human norovirus (NoV) from acute heat stress. (
  • Li D, Breiman A, le Pendu J, Uyttendaele M. Binding to histo-blood group antigen-expressing bacteria protects human norovirus from acute heat stress. (
  • Histo-blood group antigen-like substances of human enteric bacteria as specific adsorbents for human noroviruses. (
  • in the case of what are known as cold agglutinins, such as anti-P 1 , the antibody is most active at 4 °C (39 °F). Most antibodies used in blood grouping must be searched for in immunized donors. (
  • Antibody made in response to a foreign red cell antigen is usually not harmful but does require subsequent transfusions to be antigen-negative. (
  • The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood typing. (
  • Immunohistochemistry: Lewis A Blood Group Antigen Antibody (7LE) [NB500-525] - Staining of human colon adenocarcinoma (paraffin-embedded sections) with anti-Blood Group Lewis a (7LE). (
  • The antibody 7LE recognizes Lewisa blood group antigen, a carbohydrate determinant carried on both glycolipids and glycoproteins, expressed in colonic epithelial cells. (
  • Discover related pathways, diseases and genes to Lewis A Blood Group Antigen Antibody (NB500-525). (
  • Mouse monoclonal antibody raised against native human Blood Group Antigen A. (
  • This antibody is applicable for tissue staining in tumor patients with blood groups A and AB. (
  • Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human colon cancer with Blood Group Antigen A monoclonal antibody, clone 33C13 (Cat # MAB13290). (
  • The hybridoma antibody TL5, which precipitates the EGF receptor from the human epidermoid carcinoma cell line A431, has been shown to recognize the blood-group-A carbohydrate structure. (
  • This conclusion has been reached from studies of (a) the binding of the antibody to glycoproteins and haemagglutination of erythrocytes with known blood-group-antigen activities and (b) the inhibition of binding of the antibody to a radiolabelled blood-group-A-active glycoprotein by structurally defined oligosaccharides. (
  • Blood Group Kp(bc) (Kell antigen) antibody LS-C77089 is an unconjugated mouse monoclonal antibody to human Blood Group Kp(bc) (Kell antigen). (
  • Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (
  • In cases when e.g. antibody mixtures, autoantibodies or alloantibodies to high-prevalence blood group antigens are present, the clear identification could be problematic due to unspecific positive (false positive) or overlapping reactions in antibody screening. (
  • Seltsam A, Blasczyk R. Recombinant blood group proteins for use in antibody screening and identification tests. (
  • Seltsam A, Blasczyk R. Recombinant blood group proteins in clinical practice - from puzzling to binary antibody testing. (
  • Mouse Monoclonal anti-Blood Group A antigen antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Mouse Monoclonal anti-Blood Group A antigen. (
  • Mouse Monoclonal anti-Blood Group A antigen is a monoclonal antibody which is greatly purified and with high binding affinity for the antigen that it is risen against. (
  • An antigen having the ability to react with more than one specific antibody. (
  • Methods: The Rh blood group antigen and antibody were detected by micro column gel technique in 16300 patients. (
  • A molecule that is capable of binding to an antibody or to an antigen receptor on a T cell, especially one that induces an immune response. (
  • Knowledge of the antigen frequencies is important to assess risk of antibody formation and to guide the probability of finding antigen -negative donor blood , which is especially useful when blood is required for a patient who has multiple red cell alloantibodies . (
  • A monoclonal antibody-specific immobilization of erythrocyte antigens (MAIEA) assay was used to locate KANNO antigen on RBC-specific membrane protein. (
  • Monoclonal antibodies (structurally identical antibodies produced by hybridomas) to blood groups are replacing some of the human blood grouping reagents. (
  • In addition to their use in blood grouping, these monoclonal antibodies can be of use in defining the hereditary background (heterogenicity) and structure of the red cell antigen . (
  • for example, group A blood contains A antigens on red cell surfaces and anti-B antibodies in the surrounding serum. (
  • If these antibodies combine with the appropriate antigen, the result is hemolytic transfusion reaction and possibly death. (
  • Rh-negative persons transfused with Rh-positive blood will make anti-D antibodies from 50 to 75 percent of the time. (
  • Landsteiner found that there are substances in the blood, antigens and antibodies, that induce clumping of red cells when red cells of one type are added to those of a second type. (
  • Blood containing red cells with type A antigen on their surface has in its serum (fluid) antibodies against type B red cells. (
  • If, in transfusion , type B blood is injected into persons with type A blood, the red cells in the injected blood will be destroyed by the antibodies in the recipient's blood. (
  • In the same way, type A red cells will be destroyed by anti-A antibodies in type B blood. (
  • There may be naturally occurring antibodies without immunisation , especially in the case of the ABO system and matching blood groups is important for safe transfusion . (
  • Inhibition of MT-450 rat mammary tumour growth by antibodies recognising subtypes of blood group antigen B," Oncogene , vol. 18, no. 31, pp. 4485-4494, 1999. (
  • They were demonstrated in tissue sections by immunohistochemical staining techniques with monoclonal antibodies to H-antigen and N -acetyllactosamine. (
  • This course aims to provide the learner with an overview of the Rh blood group system, to review the unique characteristics of the antigens and antibodies of the system, to describe the naming conventions associated with the system, and to stimulate an appreciation for the complexities of the Rh system. (
  • List characteristics of antibodies commonly encountered in the Rh blood group system, phase of reactivity, ability to cross the placenta, and effect of enzyme treatment during testing. (
  • Blood group FSLs have been printed onto silica and nitrocellulose surfaces, and used to identify blood group antibodies in diagnostic and research samples. (
  • This research, using mice, set out to determine if FSL constructs could be used to manipulate the immune system by modifying membrane antigens and inhibiting/neutralizing antibodies. (
  • Blood group AB individuals have both A and B antigens on the surface of their RBCs, and their blood plasma does not contain any antibodies against either A or B antigen. (
  • The detection of antibodies to blood group antigens is crucial in pre and posttransfusion testing to allow for adequate blood supply of patients requiring blood transfusions. (
  • Recombinant blood group antigens (rBGA) by imusyn can specifically inhibit antibodies and therefore minimize the risk of incompatible blood transfusions. (
  • Recombinant blood group proteins facilitate the detection of alloantibodies to highprevalence antigens and reveal underlying antibodies: results of an international study. (
  • Individuals produce antibodies against the antigens not present in their own blood. (
  • Rh type is important in humans because of its role in hemolytic disease of the newborn, in which the antibodies of an Rh- woman (lacking the D antigen protein of the Rh blood group) target the D antigen on the red blood cells of an Rh+ fetus. (
  • Cell surface antigens can stimulate the production of antibodies by B lymphocytes and cytotoxic responses by white blood cells, e.g., granulocytes, monocytes, and lymphocytes. (
  • Conclusion: Rh blood group antigen detection and the implementation of the same antigen delivery can avoid the Rh blood sys- tem to produce antibodies, reduce the various adverse reactions caused by clinical delivery, and improve the safety of clinical delivery. (
  • Some believe that antibodies to MICA antigens may play a significant role in acute and/or chronic graft rejection and therefore offer a new target for improving graft survival. (
  • MICA antigens could thereby result in direct damage to the graft due to these anti-MICA antibodies. (
  • Zou Y, Stastny P, Susal C, Dohler B, Opelz G. Antibodies against MICA antigens and kidney transplant rejection. (
  • An antigen is any substance that causes your immune system to produce antibodies against it. (
  • An antigen is a particle with that is recognized by the immune system (b cells, antibodies, t cells, etc. (
  • The Helicobacter pylori adhesin BabA binds mucosal ABO/Le(b) blood group (bg) carbohydrates. (
  • Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity. (
  • Bactérie Helicobacter pylori en microscopie électronique à balayage. (
  • Atomic force microscopy measurements reveal multiple bonds between Helicobacter pylori blood group antigen binding adhesin and Lewis b ligand. (
  • The strength of binding between the Helicobacter pylori blood group antigen -binding adhesin (BabA) and its cognate glycan receptor, the Lewis b blood group antigen (Le(b)), was measured by means of atomic force microscopy . (
  • The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. (
  • These carbohydrate antigens exist in a number of variant forms expressed on glycoproteins, glycolipids and oligosaccharides which are ubiquitously distributed on cell surfaces, in the extracellular matrix, in secretions, and in staggering numbers. (
  • By using KODE™ technology, carbohydrate antigens were introduced to red cells (kodecytes) and visualization molecules provided a novel method with which to study and manipulate the immune response. (
  • Some viruses within the Caliciviridae family initiate their replication cycle by attachment to cell surface carbohydrate moieties, histo-blood group antigens (HBGAs), and/or terminal sialic acids (SAs). (
  • In humans, pigs, and oysters, histo-blood group antigens (HBGAs) act as attachment factors for HuNoVs. (
  • Histo-blood group antigens (HBGAs) are carbohydrates and are known as the attachment factors for HuNoV infection in humans. (
  • It was reported recently that HuNoVs can infect B cells in vitro with the help of enteric bacteria expressing histo-blood group antigens (HBGAs) ( 15 ). (
  • In this study, we demonstrated that the surface spike protein VP8* of the major P genotypes of human RVs interacts with the secretor histo-blood group antigens (HBGAs). (
  • Although the precise biological role of lysosomal membrane-associated glycoproteins (LAMPs) and ABH histo-blood group antigens (HBGAs) remains somewhat unclear, they are thought to be related to cell differentiation, cellular adhesion, and tumorigenesis. (
  • Research into dietary effects on the human gut microbiota led to its classification into three proposed enterotypes, but also revealed the surprising role of blood group antigens in shaping those populations. (
  • Not if the patient is a female less than 45 years old (childbearing possible), unless life-threatening hemorrhage is present and transfusion of Rh-positive blood is lifesaving. (
  • As explained above, the most important blood group systems for transfusion of red cells are ABO and Rh . (
  • Rh-positive blood should never be given to Rh-negative females before or during the childbearing age unless Rh negative blood is not available and the transfusion is lifesaving. (
  • International society of blood transfusion committee on terminology for red blood cell surface antigens: macao report," Vox Sanguinis , vol. 96, no. 2, pp. 153-156, 2009. (
  • E. Smart and B. Armstrong, "Blood group systems," International Society of Blood Transfusion Science Series , vol. 3, pp. 68-92, 2008. (
  • R. K. Chaudhary, J. S. Shukla, and V. Ray, "Minor Red cell antigens in north Indian blood donor population," Indian Journal of Hematology and Blood Transfusion , vol. 21, pp. 34-35, 2003. (
  • The International Society of Blood Transfusion (ISBT) designates around 270 blood group antigens. (
  • Still, Vel-positive individuals show great variability in Vel antigen expression, creating a risk for Vel blood typing errors and transfusion reactions. (
  • Additionally, its design to protect against invasion of foreign antigens, creates a major hurdle for transfusion and transplantation. (
  • Incompatible mice were created by immunization with salivary blood group substance A with the successful production of anti-A and transfusion of A kodecytes. (
  • It was demonstrated that FSL-A was able to neutralize circulating anti-A, mitigating the consequences of kodecyte-incompatible red blood cell transfusion, and allowing for normal cell survival for up to 72 hours. (
  • essential resource in the hematology, transfusion and immunogenetics fields since its first publication in the late 1990s.The third edition of The Blood Group Antigen FactsBook has been completely revised, updated and expanded to cover all 33 blood group systems. (
  • The human ABO blood group system is very significant in transfusion and transplantation, and with a few exceptions remains polymorphic in most human populations. (
  • Blood transfusion in clinical medicine / P. L. Mollison, C. P. Engelfriet, Marcela Contreras. (
  • External quality assessment for blood transfusion laboratory practice : establishing an EQA scheme in blood group serology. (
  • This will facilitate the procurement of antigen-matched blood for transfusion to multitransfused patients. (
  • Previous studies have suggested histo-blood group antigens (HBGA)-like structures in the oyster tissues as ligands for norovirus binding and persistence. (
  • Compared with the same cell numbers of non-HBGA expressing E. coli, the presence of HBGA-expressing E. coli could always maintain higher antigen integrity, as well as mucin-binding ability of NoV VLPs of both GI.1 and GII.4 after heat-treatment at 90 C for 2 min. (
  • Aims: To determine if histo-blood group antigens (HBGA) present in oyster gastrointestinal (GI) cells mediate accumulation of human noroviruses (NoV) in oyster GI cells. (
  • Protein belonging to the set of cell surface antigens found chiefly, but not solely, on blood cells. (
  • This protein is the basis of the ABO blood group system. (
  • MA1-7667 detects AB human blood protein from human samples. (
  • The MA1-7667 immunogen is AB human blood protein. (
  • AB human blood protein. (
  • The erythrocyte component carrying the Duffy blood group antigen Fya has been identified as a 35- to 43-kilodalton protein. (
  • M1 protein showed high affinity for several terminal galactose blood group antigen structures. (
  • Spike protein VP8* of human rotavirus recognizes histo-blood group antigens in a type-specific manner. (
  • The protein marker in the Rh group of antigens that stimulates the greatest immune response. (
  • An antigen is a protein of specific shape that can serve to mark or help identify a cell / virus / protein / etc., to the immune system of the body (its white blood cells). (
  • Integrative genome analysis identified the KANNO blood group antigen as prion protein. (
  • Two covalently linked proteins, Kell and XK, constitute the Kell blood group system. (
  • Kell, a 93-Kd type II glycoprotein, is highly polymorphic and carries all but one of the known Kell antigens, and XK, which traverses the membrane ten times, carries a single antigen, the ubiquitous Kx. (
  • citation needed] The generalized reactions proposed to be catalyzed by KXA family members are: 1) Amino acid or peptide (out) → Amino acid or peptide (in) 2) Phospholipid (inner monolayer of the plasma membrane) → Phospholipid (outer monolayer of the plasma membrane) The X-linked McLeod syndrome is defined by absent Kx red blood cell antigen and weak expression of Kell antigens. (
  • Recognizes the kell blood group antigen Kpbc. (
  • The kell blood group antigens are carried on a 93kD erythrocyte membrane glycoprotein. (
  • Thus, the aim of this study was to compare the serological phenotyping of common and clinically important antigens of Rh, Duffy, Kell, Kidd and MNS blood group systems with molecular genotyping amongst multitransfused thalassaemic patients. (
  • Results: Genotyping and phenotyping results were discordant in 77 per cent of thalassaemic patients for five pairs of antithetical antigens of Rh, Duffy, Kell and Kidd blood group systems. (
  • Prevalence of Rh, Duffy, Kell, Kidd & MNSs blood group antigens in the Indian blood donor population. (
  • Biochemical studies, in vitro adherence assays, and in vivo animal models revealed that epithelial attachment of H. pylori can be mediated by the blood-group antigen-binding adhesin (BabA) targeting human Lewis b surface epitopes. (
  • The blood-group antigen-binding adhesin, BabA, has been shown to mediate adherence of H. pylori to human Lewis b (α-1,3/4-difucosylated) blood-group antigens on gastric epithelial cells ( 23 , 24 ). (
  • 2 The ABO, Hh and Lewis Blood Group in Humans and Nonhuman Primates. (
  • The fucosylated blood group antigens Lewis b (Le b ) and H-1 (Fig. 1 A) mediate adherence of H. pylori to human gastric epithelial cells in situ ( 6 ). (
  • FUT3/Blood Group Lewis A may be useful for detection of gastrointestinal, pancreatic and colorectal tumors. (
  • The results suggest the presence of additional Lewis b blood group antigen (Le(b)) binding adhesins that have not been detected previously. (
  • Conversion into Lewis antigens by the FUT3 enzyme impaired recognition, explaining their lower binding to saliva of Lewis positive phenotype. (
  • We now report that lipopolysaccharides (LPS) of H. pylori express Lewis y, Lewis x, and H type I blood group structures similar to those commonly occurring in gastric mucosa. (
  • In conclusion, our observations demonstrate that molecular mimicry between H. pylori LPS and the host, based on Lewis antigens, and provide understanding of an autoimmune mechanism for H. pylori-associated type B gastritis. (
  • The Lewis antigen system is intimately associated with ABO blood group system and the secretor system biochemically, though the genetic loci are not linked. (
  • Synthesized by intestinal epithelial cells, Lewis antigens are fucosylated glycolipids that circulate in plasma and are passively adsorbed onto red blood cells (RBCs). (
  • Lewis a and Lewis b are synthesized step by step by two separate fucosyltransferases: Lewis (FUT3) and Secretor (FUT2), which add fucose moieties onto type 1 glycoprotein chains to form Lewis a and type 1 chain H antigen, respectively. (
  • Lewis gene can also add a second fucose to type 1 H antigen to form Lewis b antigen. (
  • Creative Biolabs offers diverse blood group products with high-quality, including but not limited to Lewis a /Lewis b /Lewis x /Lewis y trisaccharides, tetrasaccharides and pentasaccharides, and blood group A/blood group B/blood group H trisaccharides, tetrasaccharides and pentasaccharides. (
  • Human blood group polymorphisms are known to be determined by the expression of A, B or H antigens and the Lewis antigens. (
  • Protection against microbial infections has been associated with inheritance of polymorphisms in genes encoding and regulating the expression of ABH and Lewis antigens in bodily secretions and epithelial tissue surfaces, subsequently resulting in the presentation of different glycosylated terminal antigens on the cell surface. (
  • AIM To investigate the relationship between peptic ulcer and expression of Lewis (Le) antigens as well as cagA, iceA, and vacA in H pylori isolates in Singapore. (
  • CONCLUSIONS The present study indicates that peptic ulcer disease is associated with increased expression of Lewis antigens but not cagA, iceA, or vacA genotype in H pylori isolates in our population. (
  • 9 10 Recent studies showed that the lipopolysaccharides (LPS) of most H pylori isolates express Lewis x (Le x ) and/or Le y blood group antigens, 11 and these antigens are also expressed on human gastric mucosa. (
  • Blood-group antigens are generally defined as molecules formed by sequential addition of saccharides to the carbohydrate side chains of lipids and proteins detected on erythrocytes and certain epithelial cells. (
  • The fucosylated blood group antigens are typically found on red blood cells where they define the ABO blood group system, but they are also expressed on the epithelial cell surfaces as histo-blood group antigens ( 30 ). (
  • Epithelial cell membrane-bound blood group antigens A and B are lost in premalignant and malignant oral lesions. (
  • The accumulation of type 2 chain H-antigen in oral premalignant lesions may prove helpful in early diagnosis of epithelial cancer. (
  • The oral epithelial tract is a niche highly abundant in glycosylated structures, particularly those of the ABO(H) blood group antigen family. (
  • Association of M1T1 GAS with oral epithelial cells varied significantly as a result of phenotypic differences in blood group antigen expression, with significantly higher adherence to those cells expressing H antigen structures compared to cells expressing A, B, or AB antigen structures. (
  • We investigated the role of blood group antigens in diversifying the glycosylation of buccal epithelial cells (BEC) that line the oral cavity. (
  • MICA antigens are expressed on the cell surfaces of many types of cells (epithelial, endothelial, fibroblasts, and monocytes) and act as ligands for natural killer (NK) cells. (
  • Perform heat mediated antigen retrieval before commencing with IHC staining protocol. (
  • For IHC-P use heat mediated antigen retrieval (sodium citrate). (
  • The KX Blood-group Antigen (KXA) Family (TC# 2.A.112) consists of transport proteins that are part of the TOG superfamily. (
  • The organisms, now called schistosomula, incorporate host proteins, including major histocompatibility complexes (MHCs) and blood group antigens, into their integuments. (
  • CagA is a 120-kDa immunodominant antigen that elicits a strong immunological response to H. pylori strains ( 15 , 16 ) and is used as a marker for the insertion of a large pathogenicity island encoding many proteins, several of which have been implicated in pathogenesis ( 17 ). (
  • Specifically, we characterized and statistically evaluated the expression of histo-blood group (A, B, O) antigens on N-and O-linked glycans from BEC membrane proteins of various individuals that represented different blood group type and secretor status using a porous graphitic carbon liquid chromatography electrospray ionization mass spectrometry (PGC-LC-ESI-MS) based glycomics approach. (
  • Unlike the ABO blood group, the Rh blood group antigens are proteins. (
  • Cellular antigens are proteins or oligosaccharides that mark and identify the cell surface as self or nonself . (
  • Antigens are substances, typically proteins, that are recognized by the immune system as foreign to the body. (
  • The entire segment of resected colon obtained from 15 patients with Hirschsprung's disease (HD) was examined with conventional mucin histochemistry (PASAB, HID-AB) to investigate the mucin composition and blood group-associated antigens (BGA) (sialosyl-Le a , Le a , Le y , Le b ) for detecting mucosal cell differentiation. (
  • The nonreducing termini of O-linked glycans on mucin are frequently covered with histo-blood group antigens. (
  • The recombinant enzyme expressed in Escherichia coli hydrolyzed α1,3-linked Gal in branched blood group B antigen [Galα1-3(Fucα1-2)Galβ1-R], but not in a linear xenotransplantation antigen (Galα1-3Galβ1-R). The enzyme also acted on group B human salivary mucin and erythrocytes. (
  • We suggest that this enzyme plays an important role in degrading B antigens to acquire nutrients from mucin oligosaccharides in the gastrointestinal tracts. (
  • We have also demonstrated that around 80% of O-glycans carried blood group A, B or H antigens, suggesting that the variation of gastric mucin glycosylation between individuals is partly due to the blood group status. (
  • Australian antigen A term formerly used for hepatitis B surface antigen. (
  • The original term for the Australian antigen, now called hepatitis B surface antigen (HBsAg). (
  • It's an old term for the hepatitis b surface antigen . (
  • Histo-blood group antigens are a group of glycoproteins and glycolipids whose antigenic specificity is determined by a variation in their constituent carbohydrate chains 6 . (
  • Objective: To understand the distribution of the three antigens of the Rh blood group D, C and E in the population, so as to provide the blood same as its own blood type antigen for the patients with different antigens in clinical delivery, and guide the clinical safety of blood. (
  • We have now biochemically characterized and identified the H. pylori blood group antigen-binding adhesin, BabA. (
  • Biochemical characterization of the blood group antigen-binding (BAB) activity of H. pylori . (
  • Additional substances with specific blood group activity have been found in certain plants. (
  • These antigens are oligosaccharides syntheiszed by glycosyltransferase enzymes, which create a pattern of sugars present on the outer membrane of cells or secreted glycoprotiens. (
  • Cordon-Card C, Lloyd DO, Sakamoto J, MacGroarty ME, Old LJ, Melamed MP (1976) Immunohistochemical expression of blood group antigens in normal human gastrointestinal tract and colonic carcinoma. (
  • Relationship between ABO blood groups and carcinoma of esophagus and cardia in Chaoshan inhabitants of China," World Journal of Gastroenterology , vol. 7, no. 5, pp. 657-661, 2001. (
  • A total of 56 (56%) patients belonged to blood group A. Among them, six (10.7%) patients who did not express antigen in squamous metaplasia, showed carcinoma at the moment of the biopsy (n = 3) or developed synchronous lung carcinoma (n = 3). (
  • Tissue blood group ABH and Thomsen-Friedenreich antigens in human urinary bladder carcinoma. (
  • Norovirus-host interaction: multi-selections by human histo-blood group antigens. (
  • 8 Blood Group Antigens as Receptors for Pathogens. (
  • T cells can be activated by specific antigens through their t cell receptors. (
  • the hypothesis of the biosynthetic pathways of A and B antigens from the common precursor of H antigen. (
  • We now show that this loss in premalignant lesions is accompanied by accumulation of a blood group antigen precursor. (
  • The aim of the present study was to explore the significance of the expression of histo-blood antigens in squamous metaplasia and its association to other prognostic factors, such as oncoprotein p53 expression and cellular proliferation index (Ki67) according to immunohistochemical techniques. (
  • Any of the major histocompatibility molecules present on almost all cells except human red blood cells. (
  • There is a new "minor antigen" gaining attention in the field of human leukocyte antigen (HLA) testing and kidney transplantation: the major-histocompatibility-complex (MHC) class I-related chain A, or MICA antigen. (
  • It accompanies the dbRBC , a new NCBI resource that contains clinical and DNA data about human red blood cells. (
  • It blends scientific background and clinical applications and provides busy researchers and clinicians with at-a-glance information on over 330 blood group antigens, including history and information on terminology, expression, chromosomal assignment, carrier molecular description, functions, molecular bases of antigens and phenotypes, effect of enzymes/chemicals, clinical significance, disease associations and key references. (
  • There are several different categories of blood group antigens described in humans that have great clinical importance. (
  • The most commonly described of these, because of their high polymorphism in human populations and clinical relevance, are the ABO blood groups and the Rhesus (Rh) factor. (
  • Regardless, despite their clinical significance, the blood group antigens are not useful in understanding human uniqueness. (
  • Cancer antigens are used in clinical medicine to screen body fluids for tumors or to follow the response of tumors to treatment. (
  • Compared to GI.1 and GII.4 VLPs, the GII.17 Kawasaki308 VLPs only weakly associated with long-chain saccharides containing A type, B type, H type, and Le b blood group epitopes. (
  • Publications] Tanegashima Akio: 'Ethnic differences in the expression of blood group antigens in the salivary gland secretory cells from German and Japanese non-secretor individuals. (
  • Reexpression of blood group antigens by cultured thyroid cells could not be related to the secretor status of the donors, the presence of a particular source of serum in the culture medium or cell division in vitro. (
  • The N-glycans from the secretor individuals did not express any A/B blood group determinants, but contained several terminal H-antigens. (
  • However, multivariate analysis of the O-glycans from individuals displayed segregation patterns clearly associated with their blood group type and secretor status. (
  • Susceptibility to many infectious agents is associated with ABO blood group or secretor state, or both. (
  • The Anton blood group antigen is a cell surface receptor found on some human red blood cells. (
  • Studies showed that bacterium can adhere to this receptor and cause human red blood cells to agglutinate. (
  • ABO blood group system , the classification of human blood based on the inherited properties of red blood cells ( erythrocytes ) as determined by the presence or absence of the antigens A and B, which are carried on the surface of the red cells. (
  • Rarely, ABO incompatibility may give rise to erythroblastosis fetalis (hemolytic disease of the newborn), a type of anemia in which the red blood cells of the fetus are destroyed by the maternal immune system . (
  • Any of various inherited antigens found on the surface of red blood cells that determine a blood grouping reaction with a specific antiserum. (
  • ABO BLOOD GROUP SYSTEM LECTURE SLIDE 137: The HeLa cells express H antigens on cell surface. (
  • In vitro adherence assays revealed that H. pylori bound in a lineage-specific manner to gastric surface mucous cells mediated by fucosylated blood-group antigens ( 25 ). (
  • haematology , immunology) The set of cell surface antigens found chiefly, but not solely, on blood cells . (
  • D. Ichikawa, K. Handa, and S. Hakomori, "Histo-blood group A/B antigen deletion/reduction vs. continuous expression in human tumor cells as correlated with their malignancy," International Journal of Cancer , vol. 76, no. 2, pp. 284-289, 1998. (
  • The Vel blood group antigen is expressed on the red blood cells of most individuals. (
  • Anti CD15 (BRA4F1) reacts with human CD15 antigen present on myeloid cells, mainly granulocytes but not on B cells, T cells, monocytes, erythrocytes or platelets. (
  • FSL constructs currently include carbohydrates, peptides, fluorophores, ligands and biotin and are being used in the manufacture of modified cells called ''kodecytes'' for use in blood group typing laboratories and for research purposes (1-2). (
  • These data suggest a novel mechanism for GAS attachment to host cells and propose a link between host blood group antigen expression and M1T1 GAS colonization. (
  • The ABO related antigens were also expressed in the taste buds cells of the tongue of human, Japanese monkey, rat, dog, rabbit and cat. (
  • Form these it is presumed that the ABO and related antigens are associated with the chemoreceptor systems in the taste buds cells and spermatogenesis in the deproductive organs of male mammals. (
  • Reexpression of blood group ABH antigens on the surface of human thyroid cells in culture. (
  • Using indirect immunofluorescence (IFL) on viable human thyroid cultures, it has been shown that, although adult follicular cells do not express blood group ABH antigens in vivo, they invariably reexpress the corresponding antigens on the cell surface when cultured in monolayers, even for very short periods. (
  • The absence of blood group antigens on noncultured thyroid cells was confirmed by negative IFL on cell suspensions obtained after enzymatic digestion of the glands, whereas these antigens were readily demonstrable on cell suspensions obtained by trypsinization of established monolayers. (
  • The quantitative expression of ABH antigens on individual thyroid cells was variable and the cell-surface IFL pattern due to binding of blood group isoantibodies was different from that given by organ-specific thyroid autoantibodies on viable cultures. (
  • After 2-3 wk in culture, thyroid cells became morphologically dedifferentiated and no longer displayed blood group antigens, though they still expressed cell-surface beta 2-microglobulin. (
  • Furthermore, the possibility that blood group natural isoantibodies bind to the cell surface must be taken into account in experiments in which cultured thyroid cells are exposed to human sera. (
  • Blood groups, or types, are defined by polymorphisms in the expression of immunogenic molecules in blood cells, plasma, and body secretions such as milk and saliva. (
  • Antigens on the body's own cells are called autoantigens. (
  • Antigens on all other cells are called foreign antigens. (
  • Reactions to antigens by T and B cells are part of the specific immune response. (
  • However, while graft HLA antigens cause graft rejection through interaction with recipient alloantibodies or by presentation of peptides to recipient T-cells, graft MICA antigens are thought to cause NK cell activation. (
  • A wide variety of sources of therapeutic NK cells are currently being tested clinically, including haploidentical NK cells, umbilical cord blood NK cells, stem cell-derived NK cells, NK cell lines, adaptive NK cells, cytokine-induced memory-like NK cells and chimeric antigen receptor NK cells. (
  • Therapeutic NK cells include haploidentical NK cells, chimeric antigen receptor NK cells, stem cell-derived NK cells, umbilical cord blood NK cells, NK cell lines, adaptive NK cells and cytokine-induced memory-like NK cells. (
  • If metastatic cells from a HNSCC migrate through the blood or lymph system, they usually settle in the lung or in the first lymph node encountered. (
  • Which cells are required to process antigens from foreign materials? (
  • Are antigens and t-cells related? (
  • We first identified the coding gene of the high-frequency antigen KANNO located in PRNP and the missense variation (E219K) that affects the seropositivity of the KANNO antigen, which were confirmed by PRNP overexpressed cells. (
  • A total of nine (9%) patients belonged to blood group B. Loss of antigenic expression was observed in five cases. (
  • The gene encodes a glycosyltransferase, which transfers N-acetyl D-galactosamine (group A) or D-galactose (group B) to the nonreducing ends of glycans on glycoproteins and glycolipids. (
  • The blood group H antigen is located in the nonreducing ends of the glycans in the group O subjects, resulting from the inactivation of the A1 glycosyltransferase gene. (
  • Coopers HS, Haesler WE (1978) Blood group substance as tumor antigen in distal colon. (
  • Cell Differentiation Antigens versus Tumor-Related Antigens in Childhood Acute Lymphoblastic Leukemia (ALL). (
  • The prevalence of HBsAg and anti-HBs among voluntary blood donors, professional blood donors, INBTS laboratory staff, haemophiliacs and the patients and medical personnel of three haemodialysis centres was compared. (
  • Prevalence of HBsAg was unrelated to ABO-Rh blood group but was related to age. (
  • 14 Expression of Le antigens and the prevalence of iceA have not been fully investigated in Asian countries where the prevalence of the cagA gene is high regardless of the presence of the disease. (
  • In the present study expression of Le antigens and the prevalence of cagA as well as iceA and vacA were investigated in 108 H pylori isolates in Singapore. (
  • This study found the prevalence of the typed antigens among Indian blood donors to be statistically different to those in the Caucasian, Black and Chinese populations , but more similar to Caucasians than to the other racial groups. (
  • Blood groups are characterized by erythrocyte (red blood cell) antigens with common immunologic properties (eg, group A). Blood group systems are series of such antigens encoded by a single gene or by a cluster of 2 or 3 closely linked homologous genes (eg, ABO system). (
  • Discovered over 100 years ago, the ABO blood groups were determined by the ABO gene. (
  • Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinositol-anchored to the erythrocyte membrane. (
  • We integrated a statistical approach to identify the coding gene for KANNO antigen by conducting a genome-wide association study (GWAS) on four KANNO-negative individuals and 415 healthy Japanese. (
  • Our data suggest that susceptibility to infection by GAS in the oral tract may correlate with phenotypic differences in host blood group antigen expression. (
  • Norwalk virus infection and disease is associated with ABO histo-blood group type. (
  • What is the role of histocompatibility complexes and blood group antigens in the pathophysiology of schistosomiasis (bilharzia)? (
  • Akatsuka Y, Morishima Y, Kuzushima K, Kodera Y, Takahashi T (2007) Minor histocompatibility antigens as targets for immunotherapy using allogeneic immune reactions. (
  • 5 The Duffy Blood Group System and Its Extensions in Nonhuman Primates. (
  • Persons may thus have type A , type B , type O , or type AB blood. (
  • Type O blood can be injected into persons with type A, B, or O blood unless there is incompatibility with respect to some other blood group system also present. (
  • Persons with type AB blood can receive type A, B, or O blood, as shown in the table. (
  • Blood group O is the most common blood type throughout the world, particularly among peoples of South and Central America. (
  • Brown A, Ellis IO, Embleton MJ, Baldwin RW, Turner DR, Hardcastle JD (1984) Immunohistochemical localization of Y hapten and the structurally related H type-2 blood group antigen on large bowel tumours and normal adult tissues. (
  • 7 Simian-Type Blood Groups of Nonhuman Primates. (
  • Therefore, an individual with type AB blood can receive blood from any group (with AB being preferable), but cannot donate blood to either A or B group. (
  • In adhesion assays the oral pathogen Candida albicans showed a significantly higher interaction to blood group O type BECs relative to other blood groups. (
  • In type O blood, a carbohydrate sequence called the H antigen is present. (
  • Type A and B individuals modify the H antigen by adding an additional monosaccharide to produce corresponding A and B antigens. (
  • Chimpanzees have been found thus far to have primarily type A blood, with type O less commonly. (
  • Gorillas appear to be exclusively type B. Orangutans express all three blood types. (
  • 3. antigens of a particular type collectively. (
  • See Note at blood type . (
  • A common practice for preparing red blood cell products for chronically transfused patients is to match Rh phenotype of recipient and donor by testing. (
  • Group A subgroup typing of a potential organ donor for A1 may be important, as it may preclude a solid organ transplant to a group O or group B recipient. (
  • Major incompatibility between donor ABO antigens and recipient plasma can result in acute humoral rejection of the transplanted organ. (
  • Background & objectives: In multitransfused thalassaemic patients, haemagglutination fails to phenotype the patient's blood group antigens due to the presence of donor-derived erythrocytes. (
  • Our results provide insight into the regulatory logic of Vel antigen expression, and extend the set of markers for genetic Vel blood group typing. (
  • The use of blood group and MHC alleles as genetic markers in biological anthropology gen- erated a conceptual revolution and persuaded researchers to begin to think in terms of populations and not only intems of typology. (
  • Genetic analyses of the ABO blood group system have suggested that the same antigens have emerged multiple times throughout primate evolution, and that polymorphism is maintained by balancing selection within populations. (
  • MICA antigens are encoded by a genetic locus located adjacent to HLA class I loci. (
  • Blood from 130 older, isolated, agricultural Lumbees did not show significant genetic contributions from Cherokees, Blacks or Seminoles. (
  • This may occur in cases where the individual has genetic variation that silences or alters the blood group antigen expression that is not included in the target region of the test, and also may occur with RhD zygosity testing. (
  • Anti-KANNO, a broadly reactive RBC alloantibody, is found among some Japanese pregnant women, but the genetic basis of the corresponding antigen remains unclear. (
  • Compatible donors on the basis of their possessing A, B, or O blood are shown in the table. (
  • Potential donors are also tested for some of the antigens of the Rh system , since it is essential to know whether they are Rh-positive or Rh-negative. (
  • The 3.4% incidence of HBsAg found among 168,890 voluntary donors was significantly less than the 8.4% found among 378 professional blood donors. (
  • Anti-HBs was found in 30% of voluntary blood donors, 67% of professional donors, 68% of haemodialysis patients, 39% of haemodialysis staff, 86% of haemophiliacs and in only 4.8% of HBsAg carriers. (
  • Samples from randomly selected blood donors from Delhi and nearby areas (both voluntary and replacement) were collected for extended antigen typing during the period January 2009 to January 2010. (
  • A total of 3073 blood samples from donors were phenotyped. (
  • Five H. pylori strains ( 7 ) were incubated with 125 I-labeled blood group antigen glycoconjugates ( 8 ). (
  • D ) Scatchard analysis of the H. pylori -Le b antigen interaction. (
  • Various strains of H. pylori were analyzed for binding to 125 I-labeled fucosylated blood group antigens (Fig. 1 B) ( 7 , 8 ). (
  • METHODS Expression of Le antigens in H pylori isolates obtained from patients with dyspepsia was measured by enzyme linked immunosorbent assay. (
  • Expression of two or more Le antigens (Le x , Le y , Le a , or Le b ) was significantly higher in H pylori isolated from ulcer patients than in non-ulcer patients (89.6% v 73.2%, p=0.035). (
  • Blood grouping reagents : preparation and application methods / by T. C. F. Roy, G. S. Nicholson, F. A. Ala. (
  • Most carriers of this McLeod blood group phenotype have acanthocytosis and elevated serum creatine kinase levels and are prone to develop a severe neurological disorder resembling Huntington's disease. (
  • Molecular testing to predict the red blood cell phenotype does not always reflect the phenotypic expression of the blood group antigen. (
  • Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. (
  • List the characteristics of the Rh blood group system, including basic biochemical and molecular composition as well as chromosome location and inheritance. (
  • Kulkarni S, Choudhary B, Gogri H, Patil S, Manglani M, Sharma R, Madkaikar M. Molecular genotyping of clinically important blood group antigens in patients with thalassaemia. (
  • Interpretation & conclusions: Molecular genotyping enabled the determination of the actual antigen profile in multitransfused thalassaemia patients. (
  • This process is presumed to occur through early exposure to bacteria with similar antigens. (
  • Blood Groups and Red Cell Antigens is a guide to the differences in our blood types that complicate blood transfusions and pregnancy. (
  • The FSL construct representing blood group A antigen (FSL-A) was intravenously infused into naive and anti-A-positive mice to determine in vivo antigen transformation and cell survival after A antigen-compatible and incompatible (A+biotin kodecyte) transfusions. (
  • The MICA locus encodes diverse antigens, which are similar in structure to HLA antigens. (
  • The Le b conjugate, but not the Le a conjugate, displaced the 125 I-labeled Le b antigen from BabA. (