Blood Component Removal: Any procedure in which blood is withdrawn from a donor, a portion is separated and retained and the remainder is returned to the donor.Blood Component Transfusion: The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.Platelet Transfusion: The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.Erythrocyte Transfusion: The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.Leukocyte Reduction Procedures: The removal of LEUKOCYTES from BLOOD to reduce BLOOD TRANSFUSION reactions and lower the chance of transmitting VIRUSES. This may be performed by FILTRATION or by CYTAPHERESIS.Plasma: The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.Piezosurgery: The use of HIGH-ENERGY SHOCK WAVES, in the frequency range of 20-30 kHz, to cut through mineralized tissue.Subgingival Curettage: Removal of degenerated and necrotic epithelium and underlying connective tissue of a periodontal pocket in an effort to convert a chronic ulcerated wound to an acute surgical wound, thereby insuring wound healing and attachment or epithelial adhesion, and shrinkage of the marginal gingiva. The term is sometimes used in connection with smoothing of a root surface or ROOT PLANING. (Jablonski; Illustrated Dictionary of Dentistry, 1982)Blood Preservation: The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).Blood Grouping and Crossmatching: Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.Blood Cells: The cells found in the body fluid circulating throughout the CARDIOVASCULAR SYSTEM.Lasers, Solid-State: Lasers which use a solid, as opposed to a liquid or gas, as the lasing medium. Common materials used are crystals, such as YAG (YTTRIUM aluminum garnet); alexandrite; and CORUNDUM, doped with a rare earth element such as a NEODYMIUM; ERBIUM; or HOLMIUM. The output is sometimes additionally modified by addition of non-linear optical materials such as potassium titanyl phosphate crystal, which for example is used with neodymium YAG lasers to convert the output light to the visible range.Cytapheresis: Separation of one or more kinds of cells from whole blood with the return of other blood cell constituents to the patient or donor. This is accomplished with an instrument that uses centrifugation to separate the cells into different layers based on the differences in cell density (displacement) or drag coefficients in a current (elutriation). The procedure is commonly used in adoptive transfer to isolate NK cells, lymphocytes, or monocytes.Blood Group Incompatibility: An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).Blood: The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.Blood Buffy Coat: The fraction of a blood sample, following CENTRIFUGATION, that is distinguished as a thin light-colored layer between the RED BLOOD CELLS, underneath it, and the PLASMA, above it. It is composed mostly of WHITE BLOOD CELLS and PLATELETS.Duty to Warn: A health professional's obligation to breach patient CONFIDENTIALITY to warn third parties of the danger of their being assaulted or of contracting a serious infection.Mandatory Reporting: A legal requirement that designated types of information acquired by professionals or institutions in the course of their work be reported to appropriate authorities.Smear Layer: Adherent debris produced when cutting the enamel or dentin in cavity preparation. It is about 1 micron thick and its composition reflects the underlying dentin, although different quantities and qualities of smear layer can be produced by the various instrumentation techniques. Its function is presumed to be protective, as it lowers dentin permeability. However, it masks the underlying dentin and interferes with attempts to bond dental material to the dentin.White Muscle Disease: A myodegeneration most frequent in calves and lambs whose dams have been fed during gestation or longer on feeds, especially legumes (FABACEAE), grown in certain areas where selenium is either deficient or unavailable in the soil. It has been recorded in many countries. It has been produced experimentally in several species of animals on low-selenium intake. A similar myopathy occurs naturally in goats, deer, foals, and dogs but proof of the etiology is lacking. (Merck Veterinary Manual, 5th ed)Plateletpheresis: The preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Blood Cell Count: The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.Blood Coagulation Disorders: Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.Hematocrit: The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.Isoantibodies: Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Rh-Hr Blood-Group System: Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.Tooth Root: The part of a tooth from the neck to the apex, embedded in the alveolar process and covered with cementum. A root may be single or divided into several branches, usually identified by their relative position, e.g., lingual root or buccal root. Single-rooted teeth include mandibular first and second premolars and the maxillary second premolar teeth. The maxillary first premolar has two roots in most cases. Maxillary molars have three roots. (Jablonski, Dictionary of Dentistry, 1992, p690)Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).Hemoglobins: The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Disease Transmission, Infectious: The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).Leukocytes: White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).Wounds and Injuries: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Leukocyte Count: The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.Metabolic Syndrome X: A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)Electrophoresis, Capillary: A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of PROTEINS; NUCLEIC ACIDS; and CARBOHYDRATES. (Segen, Dictionary of Modern Medicine, 1992)Electrophoresis, Microchip: A highly miniaturized version of ELECTROPHORESIS performed in a microfluidic device.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Blood Protein Electrophoresis: Electrophoresis applied to BLOOD PROTEINS.Electrophoresis: An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current.Electrophoresis, Cellulose Acetate: Electrophoresis in which cellulose acetate is the diffusion medium.Phlebotomy: The techniques used to draw blood from a vein for diagnostic purposes or for treatment of certain blood disorders such as erythrocytosis, hemochromatosis, polycythemia vera, and porphyria cutanea tarda.Research Support as Topic: Financial support of research activities.Medical Laboratory Personnel: Health care professionals, technicians, and assistants staffing LABORATORIES in research or health care facilities.Specimen Handling: Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.Laboratory Chemicals: Chemicals necessary to perform experimental and/or investigative procedures and for the preparation of drugs and other chemicals.Data Collection: Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.

Infection of apheresis cells by parvovirus B19. (1/271)

Parvovirus B19 is the only member of the Parvoviridae family known to cause disease in humans. Owing to the high level of cell tropism the virus can only replicate in proliferating and differentiating erythroid precursor cells, which are present in human bone marrow and foetal liver. As human bone marrow is very difficult to obtain, an alternative in vitro system for the propagation of B19 virus has been developed, based on the application of mobilized haemapoietic progenitor (apheresis) cells. These cells are routinely harvested from cancer patients after treatment with recombinant human granulocyte/macrophage colony-stimulating factor. Replication of parvovirus B19 in vitro is possible in these cells after stimulation with erythropoietin. Therefore, this system is an easily, accessible alternative to the use of human bone marrow in parvovirus B19 infection assays.  (+info)

CD34+ cell enumeration in peripheral blood and apheresis samples, using two laboratory diagnostic kits or an institutional protocol. (2/271)

In order to prepare the substitution of a commercially available diagnostic kit, ProCOUNT (Becton Dickinson) or Stem-Kit (Coulter Immunotech), for our institutional protocol, we compared the three techniques for the numeration of CD34+ progenitor cells in 50 peripheral blood and 51 apheresis samples, obtained from cancer patients or healthy donors. We show here that the three techniques yield results of the same order of magnitude. Although statistical analyses demonstrate significant differences between the three methods, these differences turned out to be clinically insignificant in most situations. Observed differences mostly affect samples with the highest content of CD34+ cells, while the three assays provide equivalent results for values that are close to clinically relevant thresholds (20 x 10(3) CD34+ cells/ml in peripheral blood to start apheresis, and accumulated number above 3 x 10(6) CD34+ cells/kg to stop apheresis). This study also supports the view that institutional protocols can provide a highly reliable determination of CD34+ cells counts and percentages. However, because institutional protocols often use research reagents and vary from institution to institution, the use of diagnostic kits may be prefered as one way to improve quality assurance in the practice of cell therapy.  (+info)

Superior autologous blood stem cell mobilization from dose-intensive cyclophosphamide, etoposide, cisplatin plus G-CSF than from less intensive chemotherapy regimens. (3/271)

The study purpose was to determine if G-CSF plus dose-intensive cyclophosphamide 5.25 g/m2, etoposide 1.05 g/m2 and cisplatin 105 mg/m2 (DICEP) results in superior autologous blood stem cell mobilization (BSCM) than less intensive chemotherapy. From January 1993 until May 1997, 152 consecutive patients with non-Hodgkin's lymphoma (n = 55), breast cancer (n = 47), Hodgkin's disease (n = 14), multiple myeloma (n = 9), AML (n = 9), or other cancers (n = 18) initially underwent BSCM by one of three methods: Group 1: G-CSF alone x 4 days (n = 30). Group 2: disease-oriented chemotherapy, dosed to avoid blood transfusions, followed by G-CSF starting day 7 or 8, and apheresis day 13 or 14 (n = 82). Group 3: DICEP days 1-3, G-CSF starting day 14, and apheresis planned day 19, 20 or 21 (n = 40). A multivariate analysis was performed to determine which factors independently predicted BSCM. The median peripheral blood CD34+ (PB CD34+) cell count the morning of apheresis linearly correlated with the number of CD34+ cells removed per litre of apheresis that day. The median PB CD34+ cell count and median CD34+ cells x 10(6) removed per litre of apheresis were highest for Group 3, intermediate for Group 2, and lowest for Group 1. By multivariate analysis, mobilization group (3 > 2 > 1), disease other than AML, no prior melphalan or mitomycin-C, and less than two prior chemotherapy regimens predicted better BSCM. Out of 15 Group 3 patients who had infiltrated marrows, 11 had no detectable cancer in marrow and apheresis products after DICEP. These data suggest that DICEP results in superior BSCM than less intensive chemotherapy regimens.  (+info)

Image-guided central venous catheters for apheresis. (4/271)

Apheresis is an increasingly important procedure in the treatment of a variety of conditions, sometimes performed via peripheral access because of concern over major complications associated with central venous catheter (CVC) placement. This study sought to determine the safety and success for ultrasound and fluoroscopically guided, non-tunneled dual lumen CVCs placed for apheresis. Prospective data collection was made of 200 attempted CVC placements in the radiology department utilizing real time sonographic guidance. The complications relating to placement were noted in all and the number of passes required for venepuncture and whether a single wall puncture was achieved was recorded in 185 cases. Duration of catheterization and reason for line removal were recorded in all. Our study group included 71 donors providing peripheral blood stem cells for allogeneic transplant. CVCs were successfully placed in all patients, 191 lines in the internal jugular and seven in the femoral vein. 86.5% required only a single pass and 80.5% with only anterior wall puncture. Inadvertent but clinically insignificant arterial puncture occurred in six (3%) cases. In no case did this prevent line placement. There were no other procedure-related complications. 173 (87.4%) catheters were removed the same day. No catheters were removed prematurely. There was one case of prolonged venous bleeding. Our study demonstrates the safety of central venous catheters for apheresis provided that duration of catheterization is short and real-time sonographic guidance is used for the puncture, and guide wire and catheter placement are confirmed fluoroscopically.  (+info)

Recombinant human thrombopoietin in combination with granulocyte colony-stimulating factor enhances mobilization of peripheral blood progenitor cells, increases peripheral blood platelet concentration, and accelerates hematopoietic recovery following high-dose chemotherapy. (5/271)

Lineage-specific growth factors mobilize peripheral blood progenitor cells (PBPC) and accelerate hematopoietic recovery after high-dose chemotherapy. Recombinant human thrombopoietin (rhTPO) may further increase the progenitor-cell content and regenerating potential of PBPC products. We evaluated the safety and activity of rhTPO as a PBPC mobilizer in combination with granulocyte colony-stimulating factor (G-CSF) in 29 breast cancer patients treated with high-dose chemotherapy followed by PBPC reinfusion. Initially, patients received escalating single doses of rhTPO intravenously (IV) at 0.6, 1.2, or 2.4 micrograms/kg, on day 1. Subsequent patients received rhTPO 0.6 or 0.3 micrograms/kg on days -3, -1, and 1, or 0.6 micrograms/kg on days -1 and 1. G-CSF, 5 micrograms/kg IV or subcutaneously (SC) twice daily, was started on day 3 and continued through aphereses. Twenty comparable, concurrently and identically treated patients (who were eligible and would have been treated on protocol but for the lack of study opening) mobilized with G-CSF alone served as comparisons. CD34(+) cell yields were substantially higher with the first apheresis following rhTPO and G-CSF versus G-CSF alone: 4.1 x 10(6)/kg (range, 1.3 to 17.6) versus 0.8 x 10(6)/ kg (range, 0.3 to 4.2), P =.0003. The targeted minimum yield of 3 x 10(6) CD34(+) cells/kg was procured following a single apheresis procedure in 61% of the rhTPO and G-CSF-mobilized group versus 10% of G-CSF-mobilized patients (P =.001). In rhTPO and G-CSF mobilized patients, granulocyte (day 8 v 9, P =.0001) and platelet recovery (day 9 v 10, P =.07) were accelerated, and fewer erythrocyte (3 v 4, P =.02) and platelet (4 v 5, P =.02) transfusions were needed compared with G-CSF-mobilized patients. Peripheral blood platelet counts, following rhTPO and G-CSF, were increased by greater than 100% and the platelet content of PBPC products by 60% to 110% on the first and second days of aphereses (P <.0001) with the greatest effect seen with repeated dosing of rhTPO at 0.6 microgram/kg. rhTPO is safe and well tolerated as a mobilizing agent before PBPC collection. Mobilization with rhTPO and G-CSF, in comparison to a comparable, nonrandomized G-CSF-mobilized group of patients, decreases the number of apheresis procedures required, may accelerate hematopoietic recovery, and may reduce the number of transfusions required following high-dose chemotherapy for breast cancer.  (+info)

Potential role for hyaluronan and the hyaluronan receptor RHAMM in mobilization and trafficking of hematopoietic progenitor cells. (6/271)

Although the mechanism(s) underlying mobilization of hematopoietic progenitor cells (HPCs) is unknown, detachment from the bone marrow (BM) microenvironment and motility are likely to play a role. This work analyzes the motile behavior of HPCs and the receptors involved. CD34(+)45(lo/med)Scatterlo/med HPCs from granulocyte colony-stimulating factor (G-CSF)-mobilized blood and mobilized BM were compared with steady-state BM for their ability to bind hyaluronan (HA), their expression of the HA receptors RHAMM and CD44, and their motogenic behavior. Although RHAMM and CD44 are expressed by mobilized blood HPCs, function blocking monoclonal antibodies (MoAbs) identified RHAMM as a major HA binding receptor, with a less consistent participation by CD44. Permeabilization of mobilized blood HPCs showed a pool of intracellular (ic) RHAMM and a smaller pool of icCD44. In contrast, steady-state BM HPCs have significantly larger pools of icRHAMM and icCD44. Also, in contrast to mobilized blood HPCs, for steady-state BM HPCs, MoAbs to RHAMM and CD44 act as agonists to upregulate HA binding. The comparison between mobilized and steady-state BM HPCs suggests that G-CSF mobilization is associated with depletion of intracellular stores of HA receptors and modulates HA receptor usage. To confirm that mobilization alters the HA receptor distribution and usage by HPCs, samples of BM were collected at the peak of G-CSF mobilization in parallel with mobilized blood samples. HA receptor distribution of mobilized BM HPCs was closely matched with mobilized blood HPCs and different from steady-state BM HPCs. Mobilized BM HPCs had lower pools of icHA receptors, similar to those of mobilized blood HPCs. Treatment of mobilized BM HPCs with anti-RHAMM MoAb decreased HA binding, in contrast to steady-state BM HPCs. Thus, G-CSF mobilization may stimulate an autocrine stimulatory loop for HPCs in which HA interacts with basal levels of RHAMM and/or CD44 to stimulate receptor recycling. Consistent with this, treatment of HPCs with azide, nystatin, or cytochalasin B increased HA binding, implicating an energy-dependent process involving lipid rafts and the cytoskeleton. Of the sorted HPCs, 66% were adherent and 27% were motile on fibronectin plus HA. HPC adherence was inhibited by MoAbs to beta1 integrin and CD44, but not to RHAMM, whereas HPC motility was inhibited by MoAb to RHAMM and beta1 integrin, but not to CD44. This finding suggests that RHAMM and CD44 play reciprocal roles in adhesion and motility by HPCs. The G-CSF-associated alterations in RHAMM distribution and the RHAMM-dependent motility of HPCs suggest a potential role for HA and RHAMM in trafficking of HPCs and the possible use of HA as a mobilizing agent in vivo.  (+info)

Autoaggression syndrome resembling acute graft-versus-host disease grade IV after autologous peripheral blood stem cell transplantation for breast cancer. (7/271)

Acute graft-versus-host disease (aGVHD) after autologous progenitor cell transplantation has been associated with blood transfusion or cyclosporine. Mild aGVHD grades I-II, identified as autoaggression or engraftment syndrome, has recently been described in autologous progenitor transplantation. Here, we report the first case of pathologically documented grade IV aGVHD after autologous peripheral blood progenitor cell transplantation in a patient with breast cancer. The allogeneic origin was excluded by molecular techniques, and no cyclosporine or cytokines were administered.  (+info)

Enrichment of peripheral blood CD34+ cells for transplantation using a fully automated immunomagnetic cell selection system and a novel octapeptide releasing agent. (8/271)

Positive selection of CD34+ cells is being increasingly performed to support hematological reconstitution following high-dose and dose-intensive chemotherapy and to reduce the non-target cell content of transplants. The present study was designed to evaluate the performance of an immunomagnetic cell selection system, including comparison of enzyme and peptide releasing agents and of semi-automated and fully automated selection systems. A total of 74 immunomagnetic CD34+ cell selection procedures were performed involving 55 subjects, the majority of whom had hematologic malignancies. Median CD34+ cell purity with a newly developed specific octapeptide releasing agent (98.5%; 81.0-99.0%) was significantly higher (P = 0.002) than that with chymopapain (85.8%; 28.1-99.7%). No significant differences were observed between semi-automated and fully automated systems in CD34+ cell purity or yield or time to WBC or platelet recovery. Immunomagnetic selection was found to provide highly purified populations of CD34+ cells in sufficient numbers for use in transplantation procedures. CD34+ cell transplants supported rapid and reliable hematologic reconstitution. Use of a fully automated system markedly reduced the time and labor required for immunomagnetic selection, potentially affording more standardized and reproducible positive selection of CD34+ cells.  (+info)

TY - JOUR. T1 - Immediate therapeutic efficacy of low-density lipoprotein apheresis for drug-resistant nephrotic syndrome. T2 - evidence from the short-term results from the POLARIS Study. AU - Muso, Eri. AU - Mune, Masatoshi. AU - Hirano, Tsutomu. AU - Hattori, Motoshi. AU - Kimura, Kenjiro. AU - Watanabe, Tsuyoshi. AU - Yokoyama, Hitoshi. AU - Sato, Hiroshi. AU - Uchida, Shunya. AU - Wada, Takashi. AU - Shoji, Tetsuo. AU - Yuzawa, Yukio. AU - Takemura, Tsukasa. AU - Sugiyama, Satoshi. AU - Nishizawa, Yoshiki. AU - Ogahara, Satoru. AU - Yorioka, Noriaki. AU - Sakai, Soichi. AU - Ogura, Yosuke. AU - Yukawa, Susumu. AU - Iino, Yasuhiko. AU - Imai, Enyu. AU - Matsuo, Seiichi. AU - Saito, Takao. PY - 2015/6/17. Y1 - 2015/6/17. N2 - Background: Hyperlipidemia is not merely a complication but a major exacerbating factor in longstanding nephrotic syndrome (NS). Low-density lipoprotein apheresis (LDL-A) has been reported to ameliorate dyslipidemia and induce rapid remission of NS. Several clinical ...
Aengevaeren, Wim R.M. et al "Low Density Lipoprotein Apheresis Improves Regional Myocardial Perfusion in Patients With Hypercholesterolemia and Extensive Coronary Artery Disease." Journal of the American College of Cardiology 28.7 (1996): 1696-1704. Web. 19 Feb. 2018. ...
To carry out in vitro research procedures on plasma or leukocyte components of whole blood, it is often necessary to obtain larger quantities of plasma or leukocytes than can be safely obtained by simple phlebotomy. These components can be easily and safely obtained using a well-established standard apheresis procedure that is in common use at the National Institutes of Health Apheresis Unit. This protocol describes the implementation of the same apheresis procedure at the National Blood Transfusion Center in Bamako, Mali. This is not a research protocol per se, but rather an adjunct protocol which allows healthy donors 18-55 years of age to undergo apheresis. Subjects must already be enrolled in another protocol which has been approved by the National Institute of Allergy and Infectious Diseases Institutional Review Board and the Faculty of Medicine, Pharmacy, and Odonto-Stomatology Ethics Committee ...
TY - JOUR. T1 - Associations among white blood cells, CD34+ cells and GM-CFU in predicting the optimal timing of peripheral blood stem cell collections by apheresis. AU - Boulassel, M. R.. PY - 2008/2. Y1 - 2008/2. N2 - Aims: To analyze preapheresis blood CD34+ cells and corresponding apheresis products in order to investigate whether peripheral blood CD34+ cell counts correlate with peripheral blood progenitor cell (PBPC) yields and to determine the optimal timing for starting PBPC collections in our clinical setting. Material and Methods: Thirty-eight patients with hematological malignancies and undergoing varied mobilization regimens were enrolled. White blood cell counts (WBC), CD34+ cells and granulocyte-macrophage colony-forming units (GM-CFU) enumeration were performed on blood samples taken immediately prior to each apheresis procedure and in the corresponding PBPC collection. Results: A total of 61 apheresis procedures were performed, with a median of two collections per patient (range ...
You are not able to breathe fully; you just take little breaths while you are dealing with something like this," said his father, Farrukh Farid, a co-owner of the Wallingford-based company, Edible Arrangements. After searching the Internet for answers, and traveling to hospitals in several states to talk to doctors, he was surprised to find that Dr. Mistry at YNHH had treated nine children in the United Kingdom with the same condition as his son. Two had been treated with transplants, and one of those had later married and had children. Farid considered LDL (low-density lipoprotein) apheresis treatment for his son at Johns Hopkins Medical Center and also visited homeopathic and herbal specialists in Dubai and Southeast Asia, but he believed that a liver transplant was the best solution. The Farids expected to wait at least a year for a liver donation. Farrukh was surprised three months later when the phone rang while he was home playing with his son.. "When I got the call, time stood still for ...
LDL apheresis, a potent therapeutic modality that removes cholesterol within several hours, has been reported to increase the skeletal muscle blood flow when repeated for 3 weeks.26 In the present study, we first demonstrated that a single session of LDL apheresis improved acetylcholine-induced endothelium-dependent vasodilatation associated with the reduction in plasma LDL cholesterol. This observation supports the concept that hypercholesterolemia causes endothelial dysfunction and indicates that short-term correction of hypercholesterolemia could restore endothelial function.. Although the precise mechanisms of amelioration of endothelium-dependent vasodilatation by lipid-lowering therapy remain to be elucidated, several possibilities have been suggested: (1) improvement of endothelium-derived relaxing factor (EDRF) production, (2) decrease in the inactivating factors of EDRF, (3) decrease in the endothelium-derived contracting factors, (4) regression of the diffusional barrier for EDRF, (5) ...
The global apheresis equipment market is expected to reach USD 3.7 billion by 2024, according to a new report by Grand View Research, Inc. The apheresis equipment industry is expected to be impacted by factors such as rising demand for plasma, platelets and other blood components, increasing incidence of chronic illnesses, presence and development of ideal reimbursement policies across various regions, and supportive government initiatives.. The U.S. Federal Government has been very involved in the funding of apheresis research through its benefit programs such as Medicare, Medicaid, veterans health administration military and employee insurance programs. Medicare provides coverage for apheresis regardless of whether the procedure is performed in a hospital or a blood center. In addition, private insurers have recently begun to closely examine apheresis procedures and issue policy statements pertaining to coverage.. Growing incidence of blood related disorders leading to the rise in demand for ...
Preventive Cardiology Inc. is the only practice in South Florida for B. Brauns LDL Apheresis treatment. Call today to learn more!
The Division also provides 24-hour consultation, execution, and monitoring of therapeutic apheresis procedures to all UCD clinical services, as well as other health systems in the greater Sacramento area. Therapies include plasma exchange, red cell exchange, leukoreduction and platelet reduction in addition to photopheresis. Members of the division are also involved in clinical apheresis research.. In addition to contributing to the professional development of the transfusion medicine fellow, members of the apheresis faculty are involved in teaching pathology residents and other medical trainees in the clinical applications and appropriate use of this specialized therapeutic modality.. Contact Apheresis Services at 916-734-3732.. ...
Protocol Design: This protocol is designed to perform collection of human specimens, such as blood, mucosal secretions, skin swabs, skin biopsy, or body fluids to support research studies. These samples will be used by laboratory researches in their work on the development of vaccines for HIV and other infectious diseases, to study the correlates of immunity related to infectious diseases and in laboratory work related to the development and/or validation of immunological assays.. In order to carry out research studies, it is often necessary to obtain larger quantities of plasma or mononuclea cells than can be safely obtained by simple phlebotomy. These components can be safely obtained using apheresis procedures in the Apheresis Clinic of the Clinical Center Department of Transfusion Medicine (DTM). The aphereses performed through this protocol conform to the requirements of the DTM Apheresis Clinic.. Subjects: Volunteers, at least 18 years old, (including participants in other NIH research ...
The TheraSorb® LDL therapy system consists of two reusable adsorbers, available in different sizes, that remove LDL cholesterol, Lp(a) and VLDL from the patient´s blood. The sepharose volume constituting the adsorbers is 100 mL for the LDL pro adsorber and 200 mL for the LDL adsorber. The plasma volumes processed during an LDL apheresis treatment can be adjusted to the patient´s need. Between the treatments, both adsorbers are stored in a preservation solution and must be kept at 2-8 °C. Up to 20 treatments can be performed with a single pair of either LDL pro or LDL adsorbers for one patient. The treatment is well tolerated due to the low bradykinin release, which otherwise can cause severe hypotension. Furthermore, the low extracorporeal volume of about 180 mL allows for the treatment of patients with a low body weight in double-needle mode. TheraSorb LDL removal is a highly selective procedure. - Suomi
One more dose collected may mean one more patient treated, one more person saved, or one more life renewed. Thats why more matters. And its why the Fresenius Kabi Amicus Separator is designed to help you increase your inventory of platelets, plasma, and red cells. Enhance the efficiency of your apheresis procedure, and expand the impact of your donors. ...
It has been reported that an intensive, two GMA session per week produced a higher remission rate and in a shorter time as compared with one GMA session per week in patients with active UC [24]. In this study, we found that intensive GMA as two sessions per week, up to 10 sessions and weekly GMA, up to 10 sessions were associated with similar remission rates in patients with active CD, but time to remission was significantly better with the former as compared with the latter. The mean time to remission was 5 weeks in the weekly GMA vs 3 weeks in the intensive GMA. The obvious difference between the two treatment frequencies appears to be shortening of morbidity time by intensive GMA.. Dignass et al. compared 5 and 10 GMA apheresis treatments in steroid-refractory or steroid-dependent UC patients, and reported that 5 GMA sessions were not inferior to 10 sessions [26]. In their study protocol, patients received 5 GMA treatments, once a week over 5 consecutive weeks, or 10 treatments, twice weekly ...
Waldmann, Elisa; Vogt, Anja; Crispin, Alexander; Altenhofer, Julia; Riks, Ina und Parhofer, Klaus G. (2017): Effect of mipomersen on LDL-cholesterol in patients with severe LDL-hypercholesterolaemia and atherosclerosis treated by lipoprotein apheresis (The MICA-Study). In: Atherosclerosis, Vol. 259: S. 20-25 ...
Low-density lipoprotein (LDL) cholesterol apheresis is an effective treatment in lowering LDL cholesterol, improving clinical endpoints, and lowering lipop
I thank God every day for my good health and so I feel that if by being an apheresis donor I can help someone in need of platelets. I must do my part. It is always a very pleasant experience when I visit the Eastern Hills site. Everyone there is cheerful and they always make me feel like I am appreciated for taking the time to give. They are a wonderful group.". ...
Preventive Cardiology Inc. provides comprehensive treatment for cardiovascular disease and looks to prevent heart disease. Visit our website for more info!
The Apheresis Center at the Mount Sinai Health System provides therapeutic apheresis (TA) and peripheral blood stem cell (PBSC) collection services.
Apparatus for carrying out therapeutic apheresis includes a filter device for being implanted in a blood vessel for carrying out in-vivo plasma separation having one or more elongated hollow tubes and a plurality of elongated hollow microporous fibers capable of separating plasma from whole blood at pressure and blood flow within a patients vein, a multiple lumen catheter secured to the proximal end of the filter device having one or more lumens in fluid communication with the interior of said one or more hollow tubes and a plasma return lumen, and therapeutic apheresis apparatus for removing and/or separating selected disease-related components from the separated plasma and means for directing plasma between said catheter and the selective component removal apparatus.
Wholesale Volume Controller - Select 2017 high quality Wholesale Volume Controller products in best price from certified Chinese Speaker Volume Controller manufacturers, Electronic Volume Controller Ic suppliers, wholesalers and factory on Made-in-China.com
Mudah-mudahan tulisan-tulisan saya ini bermanfaat dalam menambah wawasan rekan-rekan sejawat dalam bidang keperawatan hematologi, transplantasi Sel Induk (sel stem)dan Apheresis ...
GMA Live! is currently unavailable to stream on-demand, but may be available on Hulu with Live TV depending on regional availability. Try Live TV for free.
Anaphylactoid Reactions: Sudden and potentially life-threatening anaphylactoid reactions have occurred in some patients dialyzed with high-flux membranes treated concomitantly with an ACE inhibitor. In such patients, dialysis must be stopped immediately, and aggressive therapy for anaphylactoid reactions must be initiated. Symptoms have not been relieved by antihistamines in these situations. In these patients, consideration should be given to using a different type of dialysis membrane or a different class of antihypertensive agent. Anaphylactoid reactions have also been reported in patients undergoing low-density lipoprotein apheresis with dextran sulfate absorption and in patients undergoing desensitizing treatment with hymenoptera venom ...
Lipid apheresis effectively lowers LDL-cholesterol even in drug-unresponsive severely hypercholesterolemic patients. This results in improvement of symptoms of coronary artery disease, reduces progression of coronary atherosclerosis, and decreases coronary event rates. Besides aggressive lipid lowering itself, these effects may also be due to nonselective removal of other high molecular weight proteins leading to improved hemorheology. Lipid apheresis is also used for treating symptoms of vascular diseases outside the coronary arteries, such as peripheral arterial disease and the angioneuropathic diabetic foot syndrome. This review discusses putative effects of lipid apheresis and rheophereis on restoring pathophysiological processes involved in the development of symptoms of peripheral arterial disease, critical limb ischemia, and the diabetic foot syndrome. The clinical experience with lipid apheresis and rheopheresis in treating patients with peripheral arterial disease and the diabetic foot syndrome
Low-density lipoprotein (LDL) is the major cholesterol carrying lipoprotein in your blood. LDL apheresis is a procedure that takes blood outside the body to remove the LDL-cholesterol and then returns the plasma and blood back to the body. This procedure is used if diet or lipid-lowering drug therapy has not lowered high LDL-cholesterol levels adequately.. Dr. Amale Lteif evaluates patients who might e candidates for LDDL apheresis and overseas this procedure which is performed at Spring Mill Indiana University Infusion Center using the LIPOSORBER system.. ...
HELP LDL Apheresis Reduces Plasma Pentraxin 3 in Familial Hypercholesterolemia. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
VA Balashova, VI Rugal, SS Bessmeltsev, SV Gritsaev, NYu Semenova, SV Voloshin, ZhV Chubukina, AV Shmidt, AD Garifullin, IM Zapreeva, AA Kuzyaeva, II Kostroma, AYu Kuvshinov, AV Chechetkin Russian Research Institute of Hematology and Transfusiology, 16 2-ya Sovetskaya str., Saint Petersburg, Russian Federation, 191024 For correspondence: Valentina Andreevna Balashova, MD, PhD, 16 2-ya Sovetskaya str., Saint Petersburg, Russian Federation, 191024; Tel.: +7(812)717-19-37; e-mail: [email protected] For citation: Balashova VA, Rugal VI, Bessmeltsev SS, et al. Correlation of CD34+ Hematopoietic Stem Cells and CFU in Peripheral Blood Apheresis Products in Patients with Malignant Lymphoproliferative Diseases Before and After Cryopreservation Prior to auto-HSCT. Clinical oncohematology. 2018;11(4):368-77. DOI: 10.21320/2500-2139-2018-11-4-368-377 ABSTRACT Aim. To establish correlation between CD34+ autologous hematopoietic stem cell (HSC) count and colony-forming units (CFU) in the same peripheral blood
The American Society for Apheresis (ASFA) has issued updated recommendations on the use of therapeutic apheresis in clinical practice. Published in the Sixth Edition of the ASFA Special Issue, these evidence-based guidelines were developed by a committee of United States-based experts from transfusion medicine/apheresis, hematology/oncology, nephrology, and other relevant fields. The updated guidelines include 78 diseases, each of which was assigned an indication category (I-IV) describing the role of apheresis therapy and a grade of recommendation (1A-2C) based on the quality of evidence available.. Reference. 1. Schwartz J, Winters JL, Padmanabhan A, Balogun RA, Delaney M, Linenberger ML, Szczepiorkowski ZM, Williams ME, Wu Y, Shaz BH. Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the writing committee of the american society for apheresis: the sixth special issue. J Clin Apher 2013;28: 145-284.. ...
LIFE 18™ - Theraline pro is a tubing set for all adsorption treatments with the LIFE 18 apheresis unit. It comprises the pump cassette and tubing lines to connect the patient, the separator, the appropriate adsorbers, and the system solutions with each other. it is a sterile, single-use disposable. Two chambers are integrated as reservoirs into the pump cassette to enable a
This method of platelet collection takes two hours and is performed through an automated process called plateletpheresis.. During the collection, the donors blood flows through the tubing into the apheresis instrument. Through centrifugation, the apheresis instrument extracts only the donors platelets which are collected in a sterile bag. The rest of the blood flows back through the tubing to the donor.. This is a sterile procedure, and the disposable materials are only used once before being discarded.. For your ultimate comfort, the donation by apheresis is carried out under the constant supervision of a nurse. ...
Though you earned a built-in bloodstream transfusion it may be crucial to wait around yr. Refreshing donors can begin donating bloodstream utilizing their 16th birthday up utilizing their 66th birthday. Presented then they meet apheresis donor selection wants and also have described a minimum of one entire bloodstream donation in the previous 2 yrs, existing entire bloodstream donors are currently eligible to begin donating simply by apheresis utilizing their 18th utilizing their 61st birthday. Should the anaemia is being treated successfully combined with the finger prick experiment finished before now serving bloodstream suggests that your bodys haemoglobin will become from your logical scale, on you are likely to donate. Herpes - Ive vaginal herpes. Whether it be someone who is definitely HIV-positive donates arteries devices, as with that an body organ or tissues, yet the one who receives yet the arteries health supplement tends to create that an HIV contamination as well. In order to ...
http://www.hexareports.com/report/apheresis-equipment-market/details. Further key findings from the study suggest:. Neurology dominated the application market in terms of share at over 50.2% in 2013, due to increasing prevalence of blood disorder, plasma exchange due to growing rates of multiple sclerosis majority in the U.S.. Membrane filtration was the most dominant technology in the apheresis market, with revenue estimated at over USD 805.9 million in 2013. Centrifugation is expected to grow at the highest CAGR of 12.6% from 2014 to 2020. It finds usage in the apheresis of any blood component and is not restricted to plasma exchange as membrane filtration.. North America was the largest regional market in 2013, accounting for over 48.5% of global revenue due to the presence of high patient awareness levels, healthcare expenditure and sophisticated healthcare infrastructure.. Asia Pacific expected to grow at the fastest CAGR of 13.5% from 2014 to 2020. Large presence of unmet medical needs ...
The process of removing components of a patients or donors blood and returning the unneeded parts. This process makes it possible to remove desired elements from large volumes of blood. Platelets, red cells, white cells, stem cells, or plasma can be removed separately. Apheresis can also be used to remove undesirable elements from the blood.. Tags: A, Cancer Dictionary, Uncategorized. ...
The worldwide Apheresis Equipment Market is anticipated to expand remarkably over the forecast period (2012 to 2020). In 2015, the industry generated reven
In this study, the in vitro and in vivo antitumor properties of the IL-2-activated MNCs from UCBCs in comparison with IL-2-activated MNCs from PBCs were explored. The NK cytotoxicity levels of UCBCs were very low compared with PBCs prior to in vitro activation (data not shown). After IL-2 activation, however, there was significant antitumor cytotoxicity against NK-sensitive/LAK-resistant and LAK-sensitive tumor target cells (Fig. 1)⇓ . Similar results have been observed by other investigators (20, 21, 22, 23, 24, 25, 26) . The activated UCBCs were not only cytotoxic to hematological malignant cells but also considerably cytotoxic to human breast cancer cells (Fig. 2)⇓ . The level of cytotoxicity of activated cord blood cells against breast cancer was not different from that of similarly activated MNCs from peripheral blood apheresis product. This result is different from what we observed with K562 and Raji tumor targets. The precise reason for this difference is not clear at this ...
I was an apheresis technician for about five years during nursing school. I have tons of donor experience collecting whole blood, platelets and granulocytes, but I have (very) limited therapeutic
During an apheresis donation1, an anticoagulant is added to the blood to prevent it from clotting once outside the body.. Depending on the type of donation you make, fluids may also be administered to you during the blood collection. ...
Learn about the different Apheresis procedures available at Inova including Extracorporeal Photopheresis (ECP), Leukapheresis (White Blood Cell Depletion), Plasmapheresis (Therapeutic Plasma Exchange), Plateletpheresis (Platelet Depletion), Red Blood Cell (RBC) Exchange and Therapeutic Phlebotomy.
Apheresis platelets contain significant amounts of free PDGF, TGF-β, and VEGF in the plasma on day 1 of storage, presumably as a function of the apheresis techniques employed for isolation of a concentrated product, compared with fresh plasma isolated from whole blood drawn directly into a heparinized tube from healthy controls, which included the platelet donors. These data should not be compared with serum levels of these growth factors, which would be released during the cellular (platelet) phase of clotting resulting in much higher levels of these factors compared with plasma (25-30). Importantly, healthy donors do not have significantly increased amounts of VEGF, TGF-β, PDGF, or FGF-2 in their plasma, and the presented data support this previous work (25, 30). These concentrations increased progressively during the storage interval, showing significant accumulation in the plasma fraction compared with the previous day, and reached a relative maximum at component outdate (day 5 or 7). In ...
An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.
The study covers current and future market trends, drivers, challenges, and opportunities in US therapeutic apheresis market. It breaks down the market into hematology and oncology, neurology, rheumatology, and other therapeutic areas. Therapeutic apheresis has become an essential element of the blood and blood components industry value chain. Hospitals are the primary users of apheresis equipment and solutions; other users include blood banks and dialysis centers. End users include therapeutic apheresis nurses, referring physicians, hematologists, oncologists, rheumatologists, neurologists, nephrologists, cardiologists, and lipidologists. The study covers standard plasmapheresis or plasma exchange, extracorporeal immunoadsorption, plateletpheresis, red cell exchange, leukapheresis, and lipidpheresis. The two broad product categories are devices and disposables. The study discusses key trends that are expected to impact the market, including more applications across different therapeutics segments and
The study covers current and future market trends, drivers, challenges, and opportunities in US therapeutic apheresis market. It breaks down the market into hematology and oncology, neurology, rheumatology, and other therapeutic areas. Therapeutic apheresis has become an essential element of the blood and blood components industry value chain. Hospitals are the primary users of apheresis equipment and solutions; other users include blood banks and dialysis centers. End users include therapeutic apheresis nurses, referring physicians, hematologists, oncologists, rheumatologists, neurologists, nephrologists, cardiologists, and lipidologists. The study covers standard plasmapheresis or plasma exchange, extracorporeal immunoadsorption, plateletpheresis, red cell exchange, leukapheresis, and lipidpheresis. The two broad product categories are devices and disposables. The study discusses key trends that are expected to impact the market, including more applications across different therapeutics segments and
Background: Surgical bypass techniques and percutaneous catheter-based interventions may be used to successfully revascularize the limbs of patients with claudication. In many patients, however, the anatomic extent and distribution of arterial occlusion is too severe to permit relief of pain. Limited medical therapy is available for these pts.. Methods: A phase IIa randomized, double-blind, placebo-controlled clinical trial of autologous CD34+ stem cell (CD34) therapy was performed in pts with Rutherford class 3 at 3 centers in US. 3 treatment groups: placebo, low (1x10^5 CD34/kg body wt) and high dose (1x10^6 CD34/kg). All pts underwent mobilization with GCSF 5 mcg/kg/day SC for 5 d, followed by apheresis on d5 followed by selection for CD34 with Isolex 300i device. CD34 were injected IM at 8 locations in the ischemic limb. Placebo injections consisted of identical volumes of the diluent only.. Results: A total of 17 pts have been randomized, completed the injection procedure and completed the ...
TY - JOUR. T1 - Intermittent Granulocyte and Monocyte Apheresis Versus Mercaptopurine for Maintaining Remission of Ulcerative Colitis. T2 - A Pilot Study. AU - Sakuraba, Atsushi. AU - Sato, Toshiro. AU - Morohoshi, Yuichi. AU - Matsuoka, Katsuyoshi. AU - Okamoto, Susumu. AU - Inoue, Nagamu. AU - Takaishi, Hiromasa. AU - Ogata, Haruhiko. AU - Iwao, Yasushi. AU - Hibi, Toshifumi. PY - 2012/6. Y1 - 2012/6. N2 - The effect of granulocyte and monocyte adsorption apheresis (GMA) on prevention of relapse of ulcerative colitis (UC) is not clear. This was a pilot open-labeled, prospective, randomized, unblinded study to compare the tolerability and efficacy of intermittent GMA (once every 2weeks) with mercaptopurine to maintain remission of UC. Twenty-one patients with UC, who had achieved remission by induction therapies were randomly assigned to receive either intermittent GMA (N=10) or oral mercaptopurine (0.5mg/kg per day; N=11). The study period was 24months. The rate of the patients maintaining ...
The efficiency and efficacy of low-density lipoprotein (LDL) apheresis performed with a dextran sulphate cellulose (DSC) regenerating unit were tested in five familial hypercholesterolaemic patients. LDL apheresis was repeated four times at both bi-weekly and weekly intervals, processing one plasma volume each time. The efficiency of the procedure (i.e., the extent of lipoprotein removal) was nearly identical with both schedules. Efficacy parameters, i.e., decreases of plasma total and LDL cholesterol (TC and LDL-C) and apo B, were highly correlated (r , 0.96) with pre-apheresis levels, allowing an accurate prediction of the absolute lipid removal in the single individual. Plasma triglycerides, high-density lipoprotein cholesterol, apo A-I and apo A-II recovered rather rapidly, reaching 91-96% of the pre-apheresis values in 48 hours; the recovery of TC, LDL-C and apo B was much slower, with a relatively rapid early phase (80% recovery after about 7 days) followed by a successive slower rise. ...
Spieker, L E; Flammer, A J; Amacker, N; Sudano, I; Badimon, J J; Ruschitzka, F; Luscher, T F; Noll, G; Corti, R (2006). C-reactive protein influences shear stress-dependent platelet adhesion in patients with familiar hypercholesterolemia and coronary artery disease undergoing LDL apheresis. Thrombosis and Haemostasis, 96(4):540-542.. Sudano, I; Spieker, L E; Noll, G; Corti, R; Weber, R; Lüscher, T F (2006). Cardiovascular disease in HIV infection. American Heart Journal, 151(6):1147-1155.. Hermann, F; Spieker, L E; Ruschitzka, F; Sudano, I; Hermann, M; Binggeli, C; Lüscher, T F; Riesen, W; Noll, G; Corti, R (2006). Dark chocolate improves endothelial and platelet function. Heart, 92(1):119-120.. Sudano, I; Spieker, L E; Hermann, F; Flammer, A; Corti, R; Noll, G; Luscher, T F (2006). Protection of endothelial function: targets for nutritional and pharmacological interventions. Journal of Cardiovascular Pharmacology, 47 Sup:S136-S150.. Spieker, L E; Ruschitzka, F; Lüscher, T F; Noll, G (2004). ...
The findings presented at EAS highlight mipomersens potential to treat the unique needs of patients with severe forms of FH," said Vice President and General Manager of Genzymes Cardiovascular Business, Paula Soteropoulos. "Other than apheresis, there is no approved treatment that addresses the specific challenges faced by severe FH patients, which include elevated Lp(a) in addition to LDL-C. We believe mipomersen could play an important role as a targeted treatment for these patients." In a presentation entitled "Mipomersen, an ApoB Synthesis Inhibitor, Might Reduce Necessity for Lipid Apheresis in CAD," K.G. Parhofer, M.D., of Ludwig-Maximilians University, Munich, Germany, focused on mipomersens potential to reduce the necessity for lipid-apheresis by lowering LDL-C values below thresholds for apheresis eligibility. Patients with severe forms of FH may be eligible for this treatment, a dialysis-like procedure where blood is filtered through a machine to remove excess cholesterol. ...
Another method of separating blood is through apheresis. During this procedure, blood is drawn from a donor in the same way as a routine blood donation, however instead of being collected in a bag, the blood travels via tubing to a machine where the components are separated. The machine will separate the components using either the centrifuge process where the inside of the machine spins like a centrifuge or by filtration using a series of micro filters to separate components by size. After the desired components are collected the blood travels back through the tubing and is reinfused into the donor. Apheresis may be used on patients who exhibit severe symptoms of a disease and removing the constituent helps the symptoms. However this process must be done fairly frequently and is usually used as a last resort, after other methods to control the symptoms have failed ...
We offer a variety of eLearning courses that will sharpen your knowledge of therapeutic apheresis, cell therapy and blood bank technology. Our eLearning programs address key terminology, concepts and principles related to our products and your work.
Bone marrow is collected via multiple aspirations from the posterior-superior iliac crest in a sterile environment (usually a surgical operating room) while the patient is under anesthesia. Ideally, HPCs should be collected while the patients marrow is normocellular and uninvolved by the malignancy. Currently, bone marrow HPC collection is rarely, if ever, done for the purpose of autologous transplantation because HPCs can be collected from peripheral blood and engraft more rapidly when collected this way. Hematopoietic progenitor cells are normally infrequent in the blood but are mobilized into the blood during the recovery after chemotherapy and following treatment with granulocyte colony-stimulating factor (G-CSF). Peripheral blood progenitor cells (PBPCs) are collected using apheresis with continuous-flow cell separation. One to four daily apheresis sessions are usually required to achieve the minimal target CD34+ cell dose (at least 2 × 106/kg). The collected PBPCs are subsequently ...
Conclusion: Therapeutic apheresis is a progressively developing, safe, and effective treatment modality with add-on indications. Physicians should keep track of new developments on this modality to implement the appropriate indications into clinical practice. HIPPOKRATIA 2018, 22(4): 167-172.. Keywords: therapeutic apheresis, indications, ASFA. Corresponding author: Ersan Sibel, MD, Department of Nephrology of Izmir Tepecik Research and Training Hospital, University of Health Sciences, 35170, Izmir, Turkey, tel: +902324696969, fax: +902324330756, e-mail: [email protected] Introduction. Therapeutic apheresis (TA) is a general term for all extracorporeal blood purification procedures in which components of blood are separated through an extracorporeal device to treat a disease1. Depletion of the offending pathogenic constituent from the blood is attained by discarding the collected constituents (antibodies, toxins, cellular elements, etc.) and replacing it with either patients own plasma or ...
Effects of erythrocytapheresis transfusion on the viscoelasticity of sickle cell blood.: Red blood cells containing hemoglobin S are less deformable than normal
An apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield of the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield of the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield may be associated therewith, thereby providing a blood component product.
A method separates blood by centrifugation in a rotating chamber into a first separated blood component, a residual blood fluid, and an interface between the first separated blood component and the residual blood fluid. The method withdraws the first separated blood component out of the rotating chamber through a first outlet port, and also withdraws the residual blood fluid out of the rotating chamber through a second outlet port. During the separating step, the method accumulates a second separated blood component in the interface without withdrawal from the rotating chamber by monitoring the location of the interface within the rotating chamber and maintaining the interface at a location spaced away from flow communication with both the first and second outlet pods. After a selected time period, the method shifts the location of the interface within the rotating chamber into flow communication with a selected outlet port and withdraws the second separated blood component from the rotating chamber
The growing acceptance of disposable apheresis kits due to their relatively low prices, has created abundant opportunities for small manufacturers thus expanding the market potential. Big players are launching smart platform architecture that includes technologies such as selective double filtration, plasma exchange, double filtration with adsorption, and hemoperfusion, which facilities blood purification treatments boosting the market.
The team used intervention, granulocyte/monocyte apheresis with the Adacolumn Apheresis System or sham apheresis in a 2:1 ratio for 9 weeks of treatment in a North American pivotal study.. The research team also conducted a smaller, companion study of identical design in Europe and Japan including 47 patients.. The researchers found in the pivotal study, that clinical remission rates were 17% and 11% for the granulocyte/monocyte apheresis- and sham-treatment groups, respectively.. The team observed clinical response in 44% and 39% of the granulocyte/monocyte apheresis- and sham-treatment groups, respectively.. Similar changes were observed for the apheresis- and sham-treatment groups for endoscopic remission and response, and changes in Mayo and quality-of-life scores.. The researchers noted that the companion study and pooled data from both studies also yielded similar results.. Dr Sands team concluded, "In this study, granulocyte/monocyte apheresis was well tolerated but did not demonstrate ...
Another method of separating blood is through apheresis. During this procedure, blood is drawn from a donor in the same way as a routine blood donation, however instead of being collected in a bag, the blood travels via tubing to a machine where the components are separated. The machine will separate the components using either the centrifuge process where the inside of the machine spins like a centrifuge or by filtration using a series of micro filters to separate components by size. After the desired components are collected the blood travels back through the tubing and is reinfused into the donor. Apheresis may be used on patients who exhibit severe symptoms of a disease and removing the constituent helps the symptoms. However this process must be done fairly frequently and is usually used as a last resort, after other methods to control the symptoms have failed ...
Learn about the various components of blood for religious, cultural, or personal reasons for any process that involves blood removal or storage.
Human blood consists of about 22% solids and 78% water. The components of blood are plasma, fat globules, chemicals, and gases.
Human blood consists of about 22% solids and 78% water. The components of blood are plasma, fat globules, chemicals, and gases.
Learning various parts of blood and serum and what impact they may have on an individual if the blood count is elevated or depleted
I am here to report an issue with my Lenovo X220 using an intel gma 3000. When I got the system, I was able to assign unique .icm color profiles, using
hereditary galactose intolerance, Lapp lactase deficiency or malabsorption syndrome glucose-galactose.Precautions: renovascular hypertension, bilateral renal artery stenosis, renal artery stenosis only - risk of severe hypotension and renal failure; CHF decompensation, hypotension; chronic renal insufficiency (creatinine clearance (CC) of less than 60 ml / min); significant hypovolemia and hyponatremia (due to salt-free diet and / or previous therapy with diuretics, dialysis, vomiting, diarrhea), cerebrovascular disease (including cerebrovascular insufficiency, coronary heart disease, coronary insufficiency) - the risk of excessive reduction of blood pressure; stenosis of the aortic or mitral valve, hypertrophic obstructive cardiomyopathy, hemodialysis using vysokoprotochnyh nitron polyacrylic membrane - the risk of anaphylactoid reactions; condition after kidney transplantation - is no clinical experience;apheresis procedure to low density lipoprotein (LDL), simultaneous desensitizing therapy ...
Cholesterol crystal embolism (CCE) is caused by the shedding of cholesterol crystals into the bloodstream, and it has been recently recognized as a serious complication after vascular procedures. Our
Through the use of sophisticated apheresis machines, the transfusion specialists separate patient blood into its cellular and liquid fractions and, depending on the particular disease process, cleanse an individuals blood of either harmful cellular material or soluble plasma factors. For example, by removing plasma ("plasmapheresis") the Apheresis Unit treats a large number of antibody-mediated autoimmune diseases such as myasthenia gravis (a neurological disorder), Goodpastures syndrome (a kidney disorder), and TTP/HUS (a clotting disorder often associated with viral infection or the ingestion of bacterially contaminated food).. Other procedures include removing elevated levels of white cells ("leukapheresis") to prevent the neurological and pulmonary damage resulting from impeded blood flow that can be experienced by newly diagnosed leukemic patients (hyperleukocytic syndrome) or removing and exchanging red blood cells for fresh banked cells ("erythrocytapheresis") to prevent or treat the ...
A simple blood separation kit that is suitable for small surgeries for single-usage to separate whole blood into blood components, the separation kit comprising: a) two reservoirs for separating whole blood into blood components, each reservoir being connected to the other reservoir via a hollow tube at an outlet/inlet port, permitting transfer of blood components between said reservoirs; b) a pump mechanism in communication with the two reservoirs via the hollow tube and for injecting/suctioning blood components into and out of the reservoirs via the hollow tube; and c) a valve means for substantially closing the inlet/outlet port of the reservoirs while the pump mechanism is in operation injecting/suctioning blood components into or out of the reservoirs.
Abstract: The French Registry for Plasma Exchange (PE) was set up in 1985. For 13 years it has allowed for the analysis of the techniques used, along with the indications and complications. After a decrease in the number of participating centers due to the heaviness of the data collection mode, the telematic network created in 1991 led to a new increase in participants from 26 in 1990 to 69 in 1998. Follow-up shows a slight fall in activity since some protocols ended, while the neurological pathologies remain the most frequent indicators. The important modifications observed over the years are the increase of the centrifugation technique, the development of plasma treatment, and the plasma substitution by an association of albumin-pentastarch.The French Registry for plasma exchange is the largest data base dealing with therapeutic hemapheresis. The registry set-up through the internet is the first step toward an international data base. ...
Apheresis or automated blood collection (ABC) is a procedure to remove and separate individual components of the blood such as stem cells, but also platelets. The remaining blood is then returned into the bloodstream of the patient. Apheresis may be performed via the veins of the arm. In general, however, a so called Shaldon or dialysis catheter is used. This catheter contains two lumens (channels) and is placed in a jugular or subclavian vein. The procedure does not cause pain or stress to the patient. A session takes about four hours and is repeated every day until an adequate quantity of cells has been collected, however not more than four times.. ...
Apheresis or automated blood collection (ABC) is a procedure to remove and separate individual components of the blood such as stem cells, but also platelets. The remaining blood is then returned into the bloodstream of the patient. Apheresis may be performed via the veins of the arm. In general, however, a so called Shaldon or dialysis catheter is used. This catheter contains two lumens (channels) and is placed in a jugular or subclavian vein. The procedure does not cause pain or stress to the patient. A session takes about four hours and is repeated every day until an adequate quantity of cells has been collected, however not more than four times.. ...
Terkko Navigator is a medical library community for the University of Helsinki and Helsinki University Central Hospital. Personalize your own library of feeds, journals, books, links and more ⇒ ⇒
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Blood, Plasma, and Cellular Blood Components INTRODUCTION This chapter of the Guideline provides recommendations to Sponsors of Requests for Revision for new monographs for blood, plasma, and cellular
Health,Blood, Blood groups, Blood cell, RBC,WBC, Platelates, Haemoglobin, Heart..Blood components. etc EVS MCQ Question,Short Types Question Answer.
Your doctor will provide you with detailed instructions about the administration of Mozobil (plerixafor injection) for your stem cell mobilization.
After that he walked me down to the Apheresis/Cellular Therapy clinic where the nurses had me fill out paperwork, drew more blood and checked my veins to see if Id need a tube implanted in my chest for the stem cell harvest procedure or not. They decided it would be easier to have one, so it will be done sometime in the next few weeks. ...
I am unable to make a specific diagnosis based on the information that you provide. There are a number of diseases of the kidney that are treated with apheresis and Cytoxan (cyclophosphamide). I suggest that you discuss your concerns with the physicians who are caring for your wife. They are the best to discuss the…
Homozygous Familial Hypercholesterolemia information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Blood Components & Preparation. UROOJ MUHAMMAD ISMAIL SYED ADNAN ALI WAHIDI NAJMA SOMROO NUZHAT HINA HINA KHAN SANAM QURBAN. Basic Blood Components. Red Blood Cells Platelets Fresh Frozen Plasma (FFP) Cryoprecipitated Anti-hemophilic Factor Granulocytes. Terms to...
Dry the beef cubes with paper towels and then sprinkle them with salt and pepper. In batches in single layers, sear the beef in the hot oil for 3 to 5 minutes, turning to brown on all sides. Remove the seared cubes to the plate with the bacon and continue searing until all the beef is browned. Set aside. Perhaps these socalled journalists have come to buy the idea (courtesy of the entertainment world) that a woman should be able to wear a bikini six weeks after giving birth. In this way its almost a good thing that Aishwarya hasnt snapped back into shape immediately: shes setting a good example for what a normal, healthy new mothers body should be allowed to look like. Good for her! Last apheresis donation: At least 48 hours since your last platelet apheresis donation, however, twoweek intervals are recommended between each donation. The authentic hogans lie scattered amid red rock monoliths that litter the desert like abandoned castles. At Exit 36, handpainted signs promising Navajo tacos ...
Terumo Penpol is Indias first and largest manufacturer of Blood Bags and ranks among one of the largest producers of Blood Bags in Asia.Terumo Penpol has come a long way since its beginning in 1987. Terumo Penpol offers customers a wide range of Blood Bags and Blood Bank Equipment meeting high quality standards like ISO 9001:2000, CE-Mark, and S-Mark.Our commitment to society is, better ways to better health care by providing best quality products with unmatched service levels.Categories: Blood Collection Supplies and EquipmentTerumo Penpol personifies the story of a home grown R&D initiative commercialized successfully. Practicing the concept of Quality First approach in manufacturing, Terumo Penpol has been serving Blood Centers across the globe for more than 25 years. Partnering with Terumo Corporation, Japan, a global leader in healthcare products, has enabled Terumo Penpol to harness the combined strengths in Technology and Manufacturing to continue redefining standards in Blood Transfusion
Terumo Penpol is Indias first and largest manufacturer of Blood Bags and ranks among one of the largest producers of Blood Bags in Asia.Terumo Penpol has come a long way since its beginning in 1987. Terumo Penpol offers customers a wide range of Blood Bags and Blood Bank Equipment meeting high quality standards like ISO 9001:2000, CE-Mark, and S-Mark.Our commitment to society is, better ways to better health care by providing best quality products with unmatched service levels.Categories: Blood Collection Supplies and EquipmentTerumo Penpol personifies the story of a home grown R&D initiative commercialized successfully. Practicing the concept of Quality First approach in manufacturing, Terumo Penpol has been serving Blood Centers across the globe for more than 25 years. Partnering with Terumo Corporation, Japan, a global leader in healthcare products, has enabled Terumo Penpol to harness the combined strengths in Technology and Manufacturing to continue redefining standards in Blood Transfusion
Whole blood collections are manufactured into various blood components, and each component type is intended to meet a particular patients clinical need. These include red blood cells to improve oxygen delivery to tissues, platelets to treat bleeding, or plasma to replace proteins. See the Circular of Information for more indications.
The latest issue of the Alimentary Pharmacology & Therapeutics investigates granulocyte/monocyte adsorptive apheresis in ulcerative colitis.. ...
This study will examine whether 240 µg/kg plerixafor given alone for up to 4 days is safe and well tolerated in multiple myeloma (MM) patients. In add
Plasma is a blood component, derived from whole blood by plasmapheresis, and used for various therapeutic and medical applications. Human plasma is a sourc
A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.
Background: Neurological disorders are common complications following coronary artery bypass graft (CABG). Dizziness in convalescence period is of high importance because it can prolong patients stay at the hospital and decrease in sense of rehealing. Transfusion indication is seen in hemoglobin levels ,7 g/dl; however, dizziness has been frequently observed in patients with hemoglobin levels 7-10 g/dl and they have dramatic response to transfusion. Therefore, this study was designed to evaluate effect of transfusion on dizziness in hemoglobin levels of 7-10 g/dl to set a more accurate indication for transfusion in anemic patients after elective off-pump CABG. Materials and Methods: This clinical trial study was conducted on 90 patients undergoing elective off-pump CABG surgery from January to June 2011, in Afshar cardiovascular center, Yazd, Iran. Patients with hemoglobin levels of 7-10 g/ dl measured 48 h after CABG were included in this study and those who stayed in ICU more than 48 h were ...
Cerebral and myocardial infarctions share common aspects of pathobiochemistry. The central problem is the oxygen supply of the infarcted region. To maintain this supply, H.E.L.P.-apheresis (Heparin-mediated Extracorporeal LDL/Fibrinogen Precipitation) has already proven beneficial in the prevention and therapy of myocardial infarction. Since H.E.L.P.-apheresis can lower significantly plasma viscosity and erythrocyte aggregation without reducing the oxygen transport capacity, patients with cerebral infarction (stroke) may also benefit from our experiences in myocardial ischemia. The system is designed to remove selectively plasma fibrinogen, LDL-cholesterol and lipoprotein(a) from blood circulation, simultaneously. The removal of the plasma compounds is achieved by extracorporeal precipitation with heparin at low pH. Excess heparin is completely removed by an adsorber before the plasma is given back to the patient. H.E.L.P.-apheresis has proved to be safe in patients with coronary heart disease and
What is this new research into a new treatment?. We have undertaken the first trial to use macrophages as a cell therapy for liver disease. The trial was based on our previous work on a mouse model of chronic liver disease, conducted at the MRC-CRM, which found that these macrophages helped to reduce scarring and stimulate regeneration. This was a Phase 1 safety trial in patients with established liver cirrhosis. The team separated blood cells called monocytes from the patients blood through a process called apheresis. These cells differentiated it into macrophages of a similar variety that found to stimulate regeneration in mice. What does the treatment involve?. The patient comes to be screened, to find out if their suitable for the study. The treatment involves the patient being connected to a cell separation or Apheresis Unit. The Apheresis Unit separates the monocytes (macrophage precursors) from the rest of the blood. This takes two or three hours. Those monocytes are then taken to the ...
Dear user, weve recently made some changes in our website to make it more secure & accessible. We request you to Reset your password in case you get any problem in logging in your account ...
CLOSE © Remedica 2018. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise without the prior permission of the copyright owners. While every effort is made by the publishers and editorial board to see that no inaccurate or misleading data, opinions, or statements appear in this journal, they wish to make it clear that the material contained in the publication represents a summary of the independent evaluations and opinions of the authors and contributors. As a consequence, the board, publishers, and any supporting company accept no responsibility for the consequences of any such inaccurate or misleading data or statements. Neither do they endorse the content of the publication or the use of any drug or device in a way that lies outside its current licensed application in any territory. For detailed information on any drugs or devices discussed ...
Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research, videos and posters.
You can give platelets at your local blood center. They set you up like they are taking blood and then they hook you up to an apheresis machine. You blood goes thru the machine and separated out into plasma, red blood cells and platelets. It keeps your platelets and puts the rest back in you. Its very interesting. They use them mostly for leukemia patients. Your platelets are only good for 5 days after you donate them. They said they go through them all...they never have to get rid of any. They are always in need of more. ...
Q --Could you explain why a person would receive a transfusion of just platelets, rather than getting all the good stuff contained in whole blood? I hope it is not just another way the government is
The global blood preparation market is segmented into its product type, blood thinning agents, and geography. On the basis of product type, the market is divided into blood components, whole blood, and blood derivatives.
KEGG : 36 Autosomal recessive hypercholesterolemia (ARH) is a rare disorder characterized by elevated low-density lipoprotein (LDL) serum levels, xanthomatosis, and premature coronary artery disease. Several dyslipidemias have been identified which lead to severe primary hypercholesterolemia. Among them, ARH is characterized by clinical symptoms and plasma cholesterol levels intermediate between those found in heterozygous and homozygous familial hypercholesterolemia (FH) [DS:H00155] individuals. ARH patients develop symptomatic coronary artery disease later in life and their xanthomas tend to be large and bulky. In 2001, ARH was found to be caused by mutations in the LDL receptor adaptor protein 1 (LDLRAP1). In ARH, the internalization of the ligand-receptor complex cannot occur and all the LDL receptors accumulate on the cell membrane. In general, ARH patients show a better response to lipid-lowering therapy than the FH patients, and they rarely require LDL apheresis ...
Noninvasive blood component measurement is a relevant topic in biomedical engineering. Noninvasive blood component measurement based on dynamic spectroscopy can effectively avoid the influence of individual differences and improve its prediction precision. The relationship between the perfusion index and pre
1. Taniguchi Ishikawa E*, Chang KH*, Nayak R, Olsson HA, Ficker AM, Dunn SK, Madhu MN, Sengupta A, Whitsett JA, Grimes HL, Cancelas JA. Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated membrane β1/β2-integrin expression. Nat Commun 2013 Apr 3;4:art. No. 1660. doi: 10.1038/ncomms2645. PMID: 23552075, PMCID: 3627399.. 2. Dumont LJ*, Cancelas JA*, Graminske S, Friedman KD, Vassallo RR, Whitley PH, Rugg N, Dumont DF, Herschel L, Siegal AH, Szczepiorkowski ZM, Fender L, Razatos A. In vitro and in vivo quality of leukocyte-reduced apheresis platelets stored in a new platelet additive solution. Transfusion 2013, May;53(5):972-80. PMID: 22882530. 3. Chang KH, Sanchez-Aguilera A, Shen S, Sengupta A, Madhu MN, Ficker AM, Dunn SK, Kuenzi AM, Anrett JL, Santho RA, Agirre X, Perentesis JP, Deininger MW, Zheng Y, Bustelo XR, Williams DA, Cancelas JA. Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation and survival. Blood 2012 Jul ...
Component (usually about 98%) of some tree stump removal products. It accelerates the natural decomposition of the stump by ... Combats high blood pressure and was once used as a hypotensive. Electrolyte in a salt bridge Active ingredient of condensed ... Major uses of potassium nitrate are in fertilizers, tree stump removal, rocket propellants and fireworks. It is one of the ... Stan Roark (February 27, 2008). "Stump Removal for Homeowners". Alabama Cooperative Extension System. Archived from the ...
Carbon dioxide is more readily dissolved in deoxygenated blood, facilitating its removal from the body after the oxygen has ... is formed during physiological respiration when oxygen binds to the heme component of the protein hemoglobin in red blood cells ... Because the reaction is slow, the Hb A1c proportion represents glucose level in blood averaged over the half-life of red blood ... Increased levels of this chemical are detected in the blood if red blood cells are being destroyed more rapidly than usual. ...
Goodrich, RP, et al, "Defining 'Adequate' Pathogen Reduction Performance for Transfused Blood Components." Accepted for ... Virus removal[edit]. This overarching process, which has come to be known simply as virus removal, is one in which all of the ... In many cases, researchers may be trying to extract the viruses from the blood for study, not specifically for blood ... "New York Blood Center". Nybloodcenter.org. Retrieved 2010-11-23.. *^ Ruane PH, et al., "Photochemical Inactivation of Selected ...
... blood cells and plasma. The blood plasma components, such as the antibodies, are treated outside of the body. After removal of ... Corticosteroids cause white blood cell death, lowering their numbers throughout the body. They also cause white blood cells to ... Examination of the fundus (inner surface of eye) can show no results or it can show narrowing of the blood vessels, abnormal ... Instead of treating the plasma and blood cells, they are replaced with a healthy donor mixture. Patients who respond positively ...
Blood sugars are the primary glutamate removal method from inter-synaptic spaces at the NMDA and AMPA receptor site. Persons in ... These enzymes go on to damage cell structures such as components of the cytoskeleton, membrane, and DNA. ... in which blood flow is reduced to inadequate levels. Ischemia is followed by accumulation of glutamate and aspartate in the ...
During blood feeding by Ixodid ticks, the liquid portion of the meal is first concentrated by removal of water and excess ions ... what particular components of the tick body cause these reactions is unknown, but it could be a water-soluble component that is ... Tick removal[edit]. Tick removal. Compressing the body of the tick could cause more noxious substance (allergens, salivary ... Debate around the best method of tick removal is based around two main concerns. The first is that the method of removal could ...
Those blood vessels provide nourishment and waste removal for both dermal and epidermal cells. The dermis is composed of three ... Structural components of the dermis are collagen, elastic fibers, and extrafibrillar matrix. It also contains mechanoreceptors ... Within the reticular region are the roots of the hair, sebaceous glands, sweat glands, receptors, nails, and blood vessels. The ... Apart from these cells, the dermis is also composed of matrix components such as collagen (which provides strength), elastin ( ...
Component (usually about 98%) of some tree stump removal products. It accelerates the natural decomposition of the stump by ... Combats high blood pressure and was once used as a hypotensive.[43] ... Major uses of potassium nitrate are in fertilizers, tree stump removal, rocket propellants and fireworks. It is one of the ... "Stump Removal for Homeowners". Alabama Cooperative Extension System. Archived from the original on March 23, 2012. ...
... is the removal of white blood cells (or leukocytes) from the blood or blood components supplied for blood ... of red blood cells from a processed unit of Red Blood Cells. Because blood from persons who possess the sickle cell mutation is ... defined as the routine application of this blood-processing step to all units of whole blood, red blood cells, and platelets ... After the removal of the leukocytes, the blood product is said to be leukoreduced. It is theorized that transfusions that ...
Carbon dioxide is more readily dissolved in deoxygenated blood, facilitating its removal from the body after the oxygen has ... is formed during physiological respiration when oxygen binds to the heme component of the protein hemoglobin in red blood cells ... "Blood Tests". National Heart, Lung, and Blood Institute (NHLBI). Retrieved 2019-04-27.. ... Because the reaction is slow, the Hb A1c proportion represents glucose level in blood averaged over the half-life of red blood ...
... therapy with special cells and blood components 8-90...8-91: anesthesia and pain management 8-92...8-93: patient monitoring 8- ... removal of foreign material and debris 8-12...8-13: manipulation of digestive tract and urinary tract 8-14...8-17: Therapeutic ... Operations on the blood vessels (vascular surgery) 5-40...5-41: Operations on the hematopoietic and lymphatic system 5-42...5- ...
A major component of this new constitution was the removal of blood quantum for tribal membership, which effectively increased ... From these convictions (leading to an eleven-year prison sentence and removal from office), to his then-extravagant $120,000 ... The new constitution did not come without controversy; while there was no minimum blood quantum for tribal membership, there ... was an enforced blood quantum of ¼ to be elected to tribal office. Additionally, women were given the right to vote with the ...
The average removal rate is 250 milliliter (1/2 pint) per hour. The fluid removed is isotonic to blood and therefore ... Aquapheresis therapy is delivered by three basic components: a console (the machine with two pumps), the blood filter circuit, ... The blood is outside the body for less than a minute and the total amount of blood is 33 milliliters (2.5 tablespoons). It is ... Using a form of ultrafiltration, the filter separates the excess salt and water from the blood and the blood is returned to the ...
Citric and oxalic acids are used as rust removal. As acids, they can dissolve the iron oxides, but without damaging the base ... Human blood and urine contain these plus organic acid degradation products of amino acids, neurotransmitters, and intestinal ... bacterial action on food components. Examples of these categories are alpha-ketoisocaproic, vanilmandelic, and D-lactic acids, ... In the dissociated form, they may be able to chelate the metal ions, helping to speed removal. Biological systems create many ...
... removal from the blood). In the healthy individual, the rates of appearance and disposal are essentially equal during exercise ... Although gluconeogenesis is an important component of hepatic glucose output, it alone can not sustain exercise. For this ... aids used in endurance sports to increase the volume percentage of red blood cells (hematocrit), such as through blood doping ... Dalsgaard, MK (2006). "Fuelling cerebral activity in exercising man". Journal of Cerebral Blood Flow and Metabolism. 26 (6): ...
A surgical drain is often left in the pelvis for several days to allow drainage of blood and other fluid. Additional components ... Removal of select lymph nodes in the pelvis allows microscopic evaluation for evidence of cancer within these nodes. A ... The blood vessels leading to and from the prostate are divided and tied off. Recovery typically is rapid; individuals are ... Radical retropubic prostatectomy can be performed under general, spinal, or epidural anesthesia and requires blood transfusion ...
Treatment of diabetic foot ulcers should include: blood sugar control, removal of dead tissue from the wound, wound dressings, ... A key feature of wound healing is stepwise repair of lost extracellular matrix (ECM) that forms the largest component of the ... Nitric oxide produced by EcNOS, maintains the diameter of blood vessels and proper blood flow to tissues. In addition to this, ... Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of the diabetic foot. Wound ...
... and return or exchange of blood plasma or components thereof from and to the blood circulation. It is thus an extracorporeal ... Other uses are the removal of blood proteins where these are overly abundant and cause hyperviscosity syndrome. Examples of ... In such a plasma donation procedure, blood is removed from the body, blood cells and plasma are separated, and the blood cells ... Citrate binds to calcium in the blood, calcium being essential for blood to clot. Citrate is very effective in preventing blood ...
Goodrich, RP, et al, "Defining 'Adequate' Pathogen Reduction Performance for Transfused Blood Components." Accepted for ... This overarching process, which has come to be known simply as virus removal, is one in which all of the viruses in a given ... In many cases, researchers may be trying to extract the viruses from the blood for study, not specifically for blood ... It is important to consider, however, the fact that the level of removal of the viruses is dependent on the size of the pores ...
As a major component of the high-density lipoprotein complex (protective "fat removal" particles), apo A1 helps to clear fats, ... including cholesterol, from white blood cells within artery walls, making the WBCs less likely to become fat overloaded, ... The protein, as a component of HDL particles, enables efflux of fat molecules by accepting fats from within cells (including ... Apolipoprotein A1 is the major protein component of HDL particles in plasma. Chylomicrons secreted from the intestinal ...
The rate of removal is significantly increased during sleep. However, the significance of the lymphatic system in Aβ clearance ... Roher AE, Lowenson JD, Clarke S, Woods AS, Cotter RJ, Gowing E, Ball MJ (Nov 1993). "beta-Amyloid-(1-42) is a major component ... New research has shown promise in testing whole blood samples for amyloid beta levels on the basis of electrical impedance. ... Aβ is the main component of amyloid plaques (extracellular deposits found in the brains of patients with Alzheimer's disease). ...
In humans, the blood-brain barrier, blood-cerebrospinal fluid barrier, and similar fluid-brain barriers separate the peripheral ... On one hand, γδ T cells are a component of adaptive immunity as they rearrange TCR genes to produce receptor diversity and can ... Additionally, the loss of the thymus at an early age through genetic mutation or surgical removal results in severe ... Leukocytes (white blood cells) act like independent, single-celled organisms and are the second arm of the innate immune system ...
Membrane fractionation has the advantage of minimal protein loss yet high removal of pathological plasma components. This ... Blood plasma is the liquid component of blood, which contains dissolved proteins, nutrients, ions, and other soluble components ... In whole blood, red blood cells, white blood cells, and platelets are suspended within the plasma. The goal of plasma ... There are several components that make up blood plasma, one of which is the protein albumin. Albumin is a highly water-soluble ...
... entry into the blood) and glucose disposal (removal from the blood). In the healthy individual, the rates of appearance and ... Although gluconeogenesis is an important component of hepatic glucose output, it alone can not sustain exercise. For this ... aids used in endurance sports to increase the volume percentage of red blood cells (hematocrit), such as through blood doping ... More simply put, oxygen consumption is dictated by the quantity of blood distributed by the heart as well as the working ...
... the removal and return of (components of) blood plasma to blood circulation Prairie Lindy Exchange, various lindy exchanges in ...
... reducing oxygen transfer to the blood as well as the removal of carbon dioxide. This can result in shortness of breath, a ... About 20% of the inhaled fibers are transported by cytoskeletal components of the alveolar epithelium to the interstitial ... When such fibers reach the alveoli (air sacs) in the lung, where oxygen is transferred into the blood, the foreign bodies ( ... asbestosis may produce reduction in diffusion capacity and a low amount of oxygen in the blood of the arteries. ...
... "the fate of the Jews as a sort of blood bond to tie the civil and military leadership to the Nazi cause".[127] ... Hitler's earlier ideas about forcible removal of Jews from the German-controlled territories in order to achieve Lebensraum ... Hilberg divides this bureaucracy into four components or hierarchies: the Nazi Party, the civil service, industry, and the ...
Abel, J. J., Rountree, L. G., and Turner, B. B. The removal of diffusible substances from the circulating blood by means of ... An alternative method for extracorporeal separation of blood components such as plasma or cells is apheresis. Hemodialysis can ... The blood is then pumped through the dialyzer, and then the processed blood is pumped back into the patient's bloodstream ... These communicate with the space around the hollow fibers, the "dialysate compartment." Blood is pumped via the blood ports ...
PRF accrues all blood sample components supporting healing and immunity on just one fibrin membrane [19]. Dr. Joseph Choukroun ... 31] reported that the use of PRF had no effect on pain following the surgical removal of impacted mandibular third molars and ... He used autogenous whole blood to create a PRF clot with the help of a centrifuge [20]. Growth factors (Platelet-Derived Growth ... 19] also reported that PRF had no effect on pain following removal of mandibular third molars (no impaction), similar to that ...
Red Blood Cell (RBC) Exchange and Therapeutic Phlebotomy. ... Red Blood Cell (RBC) Exchange and Therapeutic Phlebotomy. ... White Blood Cell Depletion), Plasmapheresis (Therapeutic Plasma Exchange), Plateletpheresis (Platelet Depletion), ... White Blood Cell Depletion), Plasmapheresis (Therapeutic Plasma Exchange), Plateletpheresis (Platelet Depletion), ... It is usually done to remove whole blood and red blood cells, and/or iron stores. Removal of blood from the body is called ...
... from a substance such as whole blood or plasma. Advantageously, the ... device and method for the removal of selected factors, such as cytokines or pharmaceuticals, ... The method of claim 1, wherein said blood component is plasma. 40. The method of claim 17, wherein said blood component is ... 1. A method for removing selected factors in a mammalian subjects blood or blood component, comprising contacting the blood or ...
A method for removing or reducing concentration or amount of a metabolic component in blood or plasma of a subject is also ... and the application of an electrical potential across these barriers to selectively remove metabolic components from blood or ... An electrophoresis system for removing or reducing concentration of a metabolic component from blood or plasma of a subject is ... US7066900B2 - Removal of metabolic components from blood - Google Patents. Removal of metabolic components from blood Download ...
Blood component therapy in clinical practice / edited by Robert W. Beal and James P. Isbister.. by Beal, Robert W , Isbister, ...
We show a nearly complete removal of both albumin and IgA from concentrated RBCs via this one-step-processes in samples ... The preparation of protein free RBC concentrate is important for blood transfusion to patients suffering from immunoglobulin A ... the development of a miniaturized system for removing plasma proteins and other low-molecular-weight compounds from red blood ... Acoustophoretic removal of proteins from blood components.. @article{Tenje2015AcoustophoreticRO, title={Acoustophoretic removal ...
Blood Component Removal Detailed Description:. Protocol Design: This protocol is designed to perform collection of human ... Blood is removed through a needle in the vein of one arm and spun in a machine that separates out the desired component (plasma ... Blood samples may be collected either by ordinary blood drawing (phlebotomy) or by apheresis, a procedure for collecting a ... These components can be safely obtained using apheresis procedures in the Apheresis Clinic of the Clinical Center Department of ...
... such as blood, containing at least two compounds, the relative mobilities of which in an electric field vary as a function of ... Removal of metabolic components from blood. EP1434645A4 *. Sep 4, 2002. Dec 13, 2006. Gradipore Ltd. Removal of metabolic ... is injected into the blood, upstream from the cell, at the same flow rate (that is, approximately 8 units/hour/cm of blood) by ... the cell can consist of concentric annular components or of superimposed flat components. In the latter case the height of the ...
... a residual blood fluid, and an interface between the first separated blood component and the residual blood fluid. The method ... During the separating step, the method accumulates a second separated blood component in the interface without withdrawal from ... withdraws the first separated blood component out of the rotating chamber through a first outlet port, and also withdraws the ... the rotating chamber into flow communication with a selected outlet port and withdraws the second separated blood component ...
The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some ... Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in ... at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a ... The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. ...
Apheresis and Specimen Collection Procedures to Obtain Plasma Peripheral Blood Mononuclear Cells (PBMCs) and Other Specimens ... Blood is removed through a needle in the vein of one arm and spun in a machine that separates out the desired component (plasma ... Blood samples may be collected either by ordinary blood drawing (phlebotomy) or by apheresis, a procedure for collecting a ... These components can be safely obtained using apheresis procedures in the Apheresis Clinic of the Clinical Center Department of ...
Blood Donor Leukocyte Transfusion Granulocyte Colony-Stimulation Factor Blood Component Removal Drug: Filgrastim (G-CSF) Drug: ... Granulocyte components are not recognized as a licensed blood component by the Food and Drug Administration (FDA), and neither ... Improving White Blood Cell Collection From Healthy Donors. The safety and scientific validity of this study is the ... Initial blood tests will be done to check for eligibility.. *Participants will donate granulocytes by apheresis a maximum of 12 ...
... processing the blood to harvest components such as platelets, and returning processed blood to the donor through the single ... Processing is performed by a centrifuge which separates blood components into stratified layers with a buffy coat containing ... A storage bag receives processed blood during the draw cycle and blood is squeezed from the bag during the return cycle, a ... platelets and white blood cells stably interfacing a red blood cell layer. Blood is withdrawn during a draw cycle and returned ...
Removal of selected factors from whole blood or its components. 1998-03-24. Okarma et al.. ... will drive cellular blood components against the filter membrane. Contact with cellular blood components can also clog the ... includes a blood handling unit 36. mounted on the chassis panel 26. . The blood handling unit 36. includes a peristaltic blood ... i) Blood Supply and Return Paths. The arterial blood supply path 62. and venous blood return path 64. includes lengths of ...
Removal of selected factors from whole blood or its components. US5554340 *. 23 Oct 1995. 10 Sep 1996. Sapidyne, Inc.. Assay ... Removal of selected factors from whole blood or its components. US6120734 *. 24 Jun 1994. 19 Sep 2000. Sapidyne, Inc.. Assay ... Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome. ... The barrier also functions as an immobilized component of the substrate to which the antibodies may be attached. Since assays ...
... from whole blood. More specifically, it relates to a process for making a microporous plasmapheresis membrane having an ... The present invention relates to the efficient removal of low density lipoprotein cholesterol complex (LDL-C) ... The plasma is treated in LDL-C removal device 28 exiting via plasma exit port 30. The remaining blood components (high ... The blood passes from blood removal apparatus 14 into whole blood tubing 16 and is pumped via optional blood pump 18 into LDL-C ...
Blood Component Removal (Apheresis) 12/01/2009 - "An open-label prospective randomized multicenter study shows very rapid ...
Blood Component Removal (Apheresis) 2. Transplants (Transplant) 3. Plasmapheresis 4. Spinal Fusion (Spondylosyndesis) ... Factor I; Blood Coagulation Factor I; gamma-Fibrinogen; Factor I, Coagulation; I, Coagulation Factor; gamma Fibrinogen; ... 07/01/2003 - "ECC blood flow was at least 75 ml/min. Platelet and fibrinogen measurements were made hourly, and circuit ... leading to a significant reduction in allogeneic blood products transfusions. ". 05/01/2005 - "On multiple logistic regression ...
The blood circulates through a machine that separates it into its components. The required component (plasma or cells) is ... Skin biopsy Removal of a small skin sample for microscopic analysis. An area of skin is numbed with an anesthetic and a small ... Apheresis Collection of plasma (fluid portion of blood) or blood cells for analysis. Whole blood is collected through a needle ... Genetic studies Collection of a blood sample for gene testing.. Patients will be followed at least once a year with a brief ...
Fecal Impaction Removal. *Fecal Incontinence. *Fecal Occult Blood Test. *Feedback Systems. *Fertility Treatments ...
Recruitment of white blood cells. Removal of injurious agent. Regulation (control) of response. Resolution/repair. ... Involves recruitment of cellular component of inflammatory response, (-> phagocytosis). Release of chemical mediators,. ... Local increase in blood flow (local hyperaemia). Engorgement of capillary beds. Erythema (redness). 3. Increased intravascular ... BLOOD LEUKOCYTES. POLYMORPHONUCLEAR LEUKOCYTES- Neutrophils, eosinophils, basophils. MONONUCLEAR LEUKOCYTES- Monocytes ( ...
... an activity associated with removal of various intracellular components. They also observed a decrease in LC3B, an essential ... Article: Blood-Spinal Cord Barrier Alterations in Subacute and Chronic Stages of a Rat Model of Focal Cerebral Ischemi, ... University of South Florida (USF Health). "USF researchers find stroke damages blood-spinal cord barrier." Medical News Today. ... University of South Florida (USF Health). (2016, June 14). "USF researchers find stroke damages blood-spinal cord barrier." ...
Blood Component Removal LDL Lipoproteins 2013 50 Citations Loss of plasma proprotein convertase subtilisin/kexin 9 (PCSK9) ...
Separation of blood into component parts and removal of a select portion from the blood. Plasmapharesis - plasma, ... Collection and later reinfusion of a patients own blood or blood components ... Removal of plasma from withdrawn blood by centrifuge. Collected cells are retransfused back into the donor. Fresh-frozen plasma ... Antigen on red blood cells of Rh-positive individuals. The factor was first identified in the blood of a rhesus monkey ...
... and blood test values. Articles will cover a range of topics, including medical tests, treatments, the future of research, ... Fecal occult blood test (FOBT) A test using agents that can detect certain components of blood (often iron metabolites) in ... The removal of part or all of the colon. Colonoscopy (coal un OSS kow pee) The examination of the entire length of the colon, ... A red blood cell. Red blood cells are responsible for carrying oxygen to body tissues. Erythropenia (eh REETH ro PEA nee uh) ...
  • Possible side effects include fatigue, decreased blood pressure during the procedure, dizziness, temporary increase in itching, and low grade fever. (inova.org)
  • A solution containing citrate is used to keep your blood from clotting during the treatment. (inova.org)
  • Normal brain parenchyma was automatically segmented with the time-to-peak criteria after cerebrospinal fluid removal and preliminary vessel voxel removal. (hindawi.com)
  • We confirmed the necessity of dual thresholds including CBF and CBV for proper removal of vessel voxels. (hindawi.com)
  • The automatic scaling and vessel removal techniques provide an alternative method for obtaining improved quantitative assessment of CBV and CBF in patients with thromboembolic cerebral arterial disease. (hindawi.com)
  • What factors determine the flow rate of blood through a vessel? (coursehero.com)
  • L-arginine helps maintain the body's fluid balance (urea, creatinine), and aids in wound healing, hair growth, sperm production (spermatogenesis), blood vessel relaxation (vasodilation), and fights infection. (livingnaturally.com)
  • While the process of thrombosis is not completely understood, the chief underlying cause is believed to be a lesion ( atherosclerosis ) that destroys the normal endothelial surface of the blood vessel. (britannica.com)
  • One way is by producing a blood vessel-constricting protein ( angiotensin ) that also signals the body to retain sodium and water. (healthline.com)
  • e) measuring the amount of chromogen produced in the second liquid phase in order to determine the amount of the analyte in the liquid sample, wherein the measurement is carried out in the transparent nonporous vessel of step (d) without prior removal of the porous solid phase. (google.co.uk)
  • 5. A method in accordance with claim 1 or 3 wherein said withdrawn blood is formed into an extracorporeal flowing stream, passed through a treatment station whereat said irradiation is effected and returned to said subject in a continuous operation. (google.ca)
  • 8. A method in accordance with claim 7 wherein excess quantities of said photoactivated cortisone are removed from the extracorporeal stream by withdrawing blood plasma at said centrifuge and replacing same with fresh photoactivated cortisone-free plasma. (google.ca)
  • Extracorporeal processing of blood is known to have varied uses. (google.com.au)
  • Additional uses for extracorporeal processing include extracting blood components useful in treating disease conditions or in research and/or diagnosis. (google.com.au)
  • Blood oxygenation level dependent (BOLD) signals in functional magnetic resonance imaging (fMRI) are often small compared to the level of noise in the data. (nih.gov)
  • Effect of Skin blood flow (SBF) on functional near-infrared spectroscopy (fNIRS) measurement of cortical activity proves to be an illusive subject matter with divided stances in the neuroscientific literature on its extent. (frontiersin.org)
  • This additional process will add another level of safety to the already established treatment protocols and is particularly relevant since there is no commercially available diagnostic test for detection of the blood-borne form of the vCJD agent. (bio-medicine.org)
  • The PRDT prion removal technology is presently being used in the P-Capt(R) prion filter, CE marked in September 2006, and marketed by MacoPharma for the elimination of TSEs such as vCJD in red blood cell concentrates. (bio-medicine.org)
  • The risk of transmission of CJD and vCJD by blood and blood products. (who.int)
  • Two cases of probable transmission of vCJD by blood components have now been reported. (springer.com)
  • This study describes a potential method for removing the prion particles that can cause vCJD from donated blood. (medpagetoday.com)
  • Reassure patients that in the United States and Canada the blood supply is safe, because donors are rigorously screened for potential exposure to vCJD, or mad-cow disease. (medpagetoday.com)
  • If proven in further studies using animal and human blood, it could be an a more effective alternative to the current practice in the U.S. and in Britain of screening blood donors for possible contacts with people who are known to have vCJD. (medpagetoday.com)
  • In the Dec. 8 issue of The Lancet, British researchers reported a third case of vCJD in an at-risk group who were given tainted blood transfusions. (medpagetoday.com)
  • Two other cases -- identified after death and reported two years ago -- were previously identified among 66 people who got blood transfusions from donors who subsequently developed vCJD, according to Stephen Wroe, M.D., of the National Prion Clinic at the National Hospital for Neurology and Neurosurgery in London. (medpagetoday.com)
  • A continuous forced flow electrophoresis cell and a method of operation for the fractionation of an aqueous liquid, such as blood, containing at least two compounds, the relative mobilities of which in an electric field vary as a function of the pH, in order to obtain one fraction enriched and one depleted. (google.com)
  • During the separating step, the method accumulates a second separated blood component in the interface without withdrawal from the rotating chamber by monitoring the location of the interface within the rotating chamber and maintaining the interface at a location spaced away from flow communication with both the first and second outlet pods. (google.co.uk)
  • After a selected time period, the method shifts the location of the interface within the rotating chamber into flow communication with a selected outlet port and withdraws the second separated blood component from the rotating chamber through the selected outlet port. (google.co.uk)
  • 4. The system of claim 2 , further comprising at least one valving member on the centrifuge rotor, the valving member being configured to control flow of at least some of the blood components during rotation of the rotor. (google.com)
  • To improve the quantitative assessment of cerebral blood volume (CBV) and flow (CBF) in the brain voxels from MR perfusion images. (hindawi.com)
  • Parametric measurements, such as cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), and time-to-peak (TTP), are used to evaluate local perfusions [ 1 - 5 ]. (hindawi.com)
  • While detection and correction strategies for most of these physiological and systemic interferences are widely practiced, effect of scalp-hemodynamic and skin blood flow (SBF) has been subject to much divided perspective. (frontiersin.org)
  • One major issue regularly observed in publications from researchers new to the field is the failure to consider possible signal contamination by hemodynamic changes unrelated to neurovascular coupling (i.e., scalp blood flow and systemic blood flow). (frontiersin.org)
  • The downward flow of the blood drives the filtration process. (sciencephoto.com)
  • Its function, which is not yet established, may be to regulate the rate of blood flow or to participate in the inflammatory response of an animal to injury. (britannica.com)
  • Systemic effects, such as blood pressure, respiratory and blood flow variation, alter relative blood oxyhemoglobin and deoxyhemoglobin concentrations. (spiedigitallibrary.org)
  • Leucocyte filtration is a complicated process that is influenced by factors such as the blood component's prefiltration cellular composition and plasma content, the temperature of the blood component at the time of filtration, the filtration flow rate, the number of units transfused through the filter, and the timing of the filtration step. (transfusion.com.au)
  • 7. A method in accordance with claim 3 including the further step of separating at least portions of said lymphocyte population before returning said blood to said subject, by passing said bloodstream through a continuous flow centrifuge. (google.ca)
  • Central co-ordination of the case, particularly visits his blood flow. (imagenenaccion.org)
  • however, behind the original thrombus, the whole blood content of the vein may clot to form a large mass. (britannica.com)
  • Warfarin inhibits the action of vitamin K and renders the blood less able to clot. (britannica.com)
  • Inferior Vena Cava (IVC) filters, or blood clot filters, are small devices designed to catch blood clots that may break free inside the deep veins of the body and travel toward the lungs. (aboutlawsuits.com)
  • The agency indicated that the blood clot filters should be removed in many cases once the danger of a pulmonary embolism has passed. (aboutlawsuits.com)
  • The researchers found that filter recipients were twice as likely to have a blood clot travel to their lungs than those on blood thinners. (aboutlawsuits.com)
  • A study published in August 2015 in a letter in JAMA warned that the long-term risks of IVC filters may negate any health benefits they provide in catching blood clots. (aboutlawsuits.com)
  • 1 The plasminogen (Plg) system ( Figure 1 ) is the major proteolytic pathway responsible for dissolution of blood clots. (pubmedcentralcanada.ca)
  • Dynamic-susceptibility-contrast MR imaging is used to diagnose cerebral blood perfusion. (hindawi.com)
  • Second, although the concentration-time curve measured in a venous voxel has been proposed to correct for the partial volume of blood in arterial voxels [ 14 , 15 ], the assumption that at least one venous voxel consists of 100% blood is not guaranteed for all MR brain perfusion studies [ 14 , 16 ]. (hindawi.com)
  • As a result of this success, bacterial contamination of blood products has emerged as the greatest residual source of transfusion-transmitted disease. (asm.org)
  • Since the 1980s, with the recognition of human immunodeficiency virus contamination of the blood supply, only a blood supply with a zero risk to recipients has been politically acceptable ( 67 ). (asm.org)
  • Given the reduction of viral transmission via allogeneic blood, the low but known risk of bacterial contamination has emerged as the greatest residual threat of transfusion-transmitted disease (Fig. 1 ). (asm.org)
  • Additionally, knowledge of potential bacterial contamination should enable early clinical review and consideration of antibiotic intervention in situations where components have already been transfused. (transfusion.com.au)
  • Bacterial contamination of blood components: risks, strategies, and regulation: joint ASH and AABB educational session in transfusion medicine. (transfusion.com.au)
  • In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. (google.com)
  • 3. The system of claim 2 , wherein the system is configured so that the pump pumps blood components from the chamber during rotation of the centrifuge rotor. (google.com)
  • Processing is performed by a centrifuge which separates blood components into stratified layers with a buffy coat containing. (google.es)
  • If desired, at least portions of the treated blood may then be separated, as for example by a continuous centrifuge, before returning the remaining diverted blood to the subject. (google.ca)
  • Careful analysis of the person's blood and physical condition help to determine the stage of the disease - a crucial first step in deciding on the proper course of treatment. (uptodate.com)
  • Over the last 20 years, astounding reductions in the risk of viral infection via allogeneic blood have been achieved. (asm.org)
  • To this end, astounding reductions in the viral risk of allogeneic blood has been accomplished ( 27 ). (asm.org)
  • Blood typing is a laboratory test that identifies blood group antigens (substances that stimulate an immune response) belonging to the ABO blood group system. (surgeryencyclopedia.com)
  • In addition to the well-defined hormones, other substances, which are found in blood and in tissues and are of uncertain function, may be concerned in various ways with physiological regulation in vertebrates, although their hormonal status has not yet been established. (britannica.com)
  • Promotes harmful substances removal and internal body environment cleansing. (nlstar.com)
  • Further processing produces blood products used to treat blood disorders or to replace blood lost through surgery or an accident. (sciencephoto.com)
  • Living donors must be physically fit, in good general health, and have no existing disorders such as diabetes, high blood pressure, cancer, kidney disease, or heart disease. (surgeryencyclopedia.com)
  • The total number of neutrophils in the blood, a measure of one's ability to fight infection. (oreilly.com)
  • Blood for transfusion is a potential source of infection by a variety of known and unknown transmissible agents. (asm.org)
  • Commonly known risk factors for infection with hepatitis C virus (HCV) include blood transfusion, injection drug use, intranasal cocaine use, and body tattoos. (stanford.edu)
  • Third, the phase between blood and tissues can cause signal cancellation in the voxels that consist of both blood and tissues [ 17 ]. (hindawi.com)
  • Fourth, the changes in MR relativity are different in tissues and blood [ 18 , 19 ]. (hindawi.com)
  • claimed that such changes are highly correlated with blood oxygen level dependent (BOLD) of functional magnetic resonance imaging (fMRI) and gray matter, as opposed to SBF or other soft tissues. (frontiersin.org)
  • Haemoglobin in the blood carries oxygen from the lungs or gills to the rest of the body (i.e. the tissues). (wikipedia.org)
  • Afibrinogenemia, or hypofibrinogenemia, refers to a reduction in the amount of the clotting factor fibrinogen in the blood . (britannica.com)
  • Protocol Design: This protocol is designed to perform collection of human specimens, such as blood, mucosal secretions, skin swabs, skin biopsy, or body fluids to support research studies. (clinicaltrials.gov)
  • Legal investigations may require typing of blood or such other body fluids as semen or saliva to identify criminal suspects. (surgeryencyclopedia.com)
  • In another aspect the invention is a system for controlling and driving blood fluids having infrared communication abilities to transmit and receive real time data. (google.ca)
  • In still another aspect, the invention is a system for controlling and driving blood fluids having an upright tower design that reduces the footprint of the system. (google.ca)
  • A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. (google.com.au)
  • The invention generally relates to component exchange between fluids. (google.com.au)
  • Some of these proteins enter the blood stream by purposeful secretion to orchestrate biological processes in health or in disease, for example hormones, cytokines and growth factors. (news-medical.net)
  • The collection of blood from volunteer donors has become a very successful and very refined activity. (google.co.uk)
  • Such sets have made possible large-scale collection of blood from volunteer donors at sites such as church halls, schools or offices which might be remote from medical facilities. (google.co.uk)
  • In addition, they provide a potentially much larger reservoir of donarable blood than is available from the available group of paid donors. (google.co.uk)
  • The American Red Cross asks all potential blood donors whether they have ever had a blood relative with Creutzfeldt-Jakob disease, and whether they had lived in the United Kingdom for at least three months since 1980, whether they had received a blood transfusion in England since 1980, or whether they had traveled or lived in Europe for a cumulative five years or more since 1980. (medpagetoday.com)
  • I am also collaborating with Drs. Daniel Haber and Mehmet Toner to define cancer biology across several tumor types including breast, prostate, liver and lung cancers as well as melanoma using CTCs isolated from the blood of cancer patients. (massgeneral.org)
  • FNHTR are caused not only by leucocyte antigen-antibody reactions but also by the cytokines produced by leucocytes in the transfused blood component. (transfusion.com.au)
  • This would be more effectively prevented if the leucocytes were removed immediately after the blood is collected, avoiding the formation of cytokines. (transfusion.com.au)
  • Leucodepletion of blood components removes ≥ 99% of contaminating leucocytes resulting in a reduction in the leucocyte count to less than 1 x 10 6 per unit. (transfusion.com.au)
  • Boosts blood pH to be able to assistance neutralize uric acid as well as help avoid uric acid stone make-up in the kidneys. (omex3.com)
  • When it comes to components of the urinary system, the kidneys are multi-functional powerhouses of activity. (healthline.com)
  • Urea is synthesized in the liver and transported through the blood to the kidneys for removal. (healthline.com)
  • The kidneys need constant pressure to filter the blood. (healthline.com)
  • This phase effect is TE dependent and can cause unexpected signal changes in arterial voxels that do not consist of 100% blood. (hindawi.com)
  • It is important to consider, however, the fact that the level of removal of the viruses is dependent on the size of the pores of the nanofilter. (wikipedia.org)
  • Emitted infrared lights are differentially absorbed by oxyhemoglobin and deoxyhemoglobin and relative concentrations of blood oxyhemoglobin and deoxyhemoglobin are measured, 1 providing a noninvasive technique for measuring blood oxygen level dependent (BOLD) responses to neuronal activation in the cerebral cortex. (spiedigitallibrary.org)
  • Accidental consumption or overdoses of the anticoagulant drug warfarin can lead to a deficiency of the vitamin K-dependent blood-clotting proteins and a serious bleeding tendency. (britannica.com)
  • According to the method, blood is withdrawn from the subject and passed through an ultraviolet radiation field in the presence. (google.ca)
  • Physiologic monitoring systems that detect and display ECG's, respiratory rate, non-invasive and invasive blood pressure, body temperature, airway gas concentrations, and others. (medwow.com)