Any procedure in which blood is withdrawn from a donor, a portion is separated and retained and the remainder is returned to the donor.
The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.
Centers for collecting, characterizing and storing human blood.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
The transfer of blood platelets from a donor to a recipient or reinfusion to the donor.
The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.
The removal of LEUKOCYTES from BLOOD to reduce BLOOD TRANSFUSION reactions and lower the chance of transmitting VIRUSES. This may be performed by FILTRATION or by CYTAPHERESIS.
The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.
The use of HIGH-ENERGY SHOCK WAVES, in the frequency range of 20-30 kHz, to cut through mineralized tissue.
Removal of degenerated and necrotic epithelium and underlying connective tissue of a periodontal pocket in an effort to convert a chronic ulcerated wound to an acute surgical wound, thereby insuring wound healing and attachment or epithelial adhesion, and shrinkage of the marginal gingiva. The term is sometimes used in connection with smoothing of a root surface or ROOT PLANING. (Jablonski; Illustrated Dictionary of Dentistry, 1982)
The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
The cells found in the body fluid circulating throughout the CARDIOVASCULAR SYSTEM.
Lasers which use a solid, as opposed to a liquid or gas, as the lasing medium. Common materials used are crystals, such as YAG (YTTRIUM aluminum garnet); alexandrite; and CORUNDUM, doped with a rare earth element such as a NEODYMIUM; ERBIUM; or HOLMIUM. The output is sometimes additionally modified by addition of non-linear optical materials such as potassium titanyl phosphate crystal, which for example is used with neodymium YAG lasers to convert the output light to the visible range.
Separation of one or more kinds of cells from whole blood with the return of other blood cell constituents to the patient or donor. This is accomplished with an instrument that uses centrifugation to separate the cells into different layers based on the differences in cell density (displacement) or drag coefficients in a current (elutriation). The procedure is commonly used in adoptive transfer to isolate NK cells, lymphocytes, or monocytes.
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.
The fraction of a blood sample, following CENTRIFUGATION, that is distinguished as a thin light-colored layer between the RED BLOOD CELLS, underneath it, and the PLASMA, above it. It is composed mostly of WHITE BLOOD CELLS and PLATELETS.
A health professional's obligation to breach patient CONFIDENTIALITY to warn third parties of the danger of their being assaulted or of contracting a serious infection.
A legal requirement that designated types of information acquired by professionals or institutions in the course of their work be reported to appropriate authorities.
Adherent debris produced when cutting the enamel or dentin in cavity preparation. It is about 1 micron thick and its composition reflects the underlying dentin, although different quantities and qualities of smear layer can be produced by the various instrumentation techniques. Its function is presumed to be protective, as it lowers dentin permeability. However, it masks the underlying dentin and interferes with attempts to bond dental material to the dentin.
A myodegeneration most frequent in calves and lambs whose dams have been fed during gestation or longer on feeds, especially legumes (FABACEAE), grown in certain areas where selenium is either deficient or unavailable in the soil. It has been recorded in many countries. It has been produced experimentally in several species of animals on low-selenium intake. A similar myopathy occurs naturally in goats, deer, foals, and dogs but proof of the etiology is lacking. (Merck Veterinary Manual, 5th ed)
The preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.
Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.
The part of a tooth from the neck to the apex, embedded in the alveolar process and covered with cementum. A root may be single or divided into several branches, usually identified by their relative position, e.g., lingual root or buccal root. Single-rooted teeth include mandibular first and second premolars and the maxillary second premolar teeth. The maxillary first premolar has two roots in most cases. Maxillary molars have three roots. (Jablonski, Dictionary of Dentistry, 1992, p690)
Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Data processing largely performed by automatic means.
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of PROTEINS; NUCLEIC ACIDS; and CARBOHYDRATES. (Segen, Dictionary of Modern Medicine, 1992)
A highly miniaturized version of ELECTROPHORESIS performed in a microfluidic device.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Electrophoresis applied to BLOOD PROTEINS.
An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current.
Electrophoresis in which cellulose acetate is the diffusion medium.
The techniques used to draw blood from a vein for diagnostic purposes or for treatment of certain blood disorders such as erythrocytosis, hemochromatosis, polycythemia vera, and porphyria cutanea tarda.
Financial support of research activities.
Health care professionals, technicians, and assistants staffing LABORATORIES in research or health care facilities.
Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
Chemicals necessary to perform experimental and/or investigative procedures and for the preparation of drugs and other chemicals.
Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.

Infection of apheresis cells by parvovirus B19. (1/271)

Parvovirus B19 is the only member of the Parvoviridae family known to cause disease in humans. Owing to the high level of cell tropism the virus can only replicate in proliferating and differentiating erythroid precursor cells, which are present in human bone marrow and foetal liver. As human bone marrow is very difficult to obtain, an alternative in vitro system for the propagation of B19 virus has been developed, based on the application of mobilized haemapoietic progenitor (apheresis) cells. These cells are routinely harvested from cancer patients after treatment with recombinant human granulocyte/macrophage colony-stimulating factor. Replication of parvovirus B19 in vitro is possible in these cells after stimulation with erythropoietin. Therefore, this system is an easily, accessible alternative to the use of human bone marrow in parvovirus B19 infection assays.  (+info)

CD34+ cell enumeration in peripheral blood and apheresis samples, using two laboratory diagnostic kits or an institutional protocol. (2/271)

In order to prepare the substitution of a commercially available diagnostic kit, ProCOUNT (Becton Dickinson) or Stem-Kit (Coulter Immunotech), for our institutional protocol, we compared the three techniques for the numeration of CD34+ progenitor cells in 50 peripheral blood and 51 apheresis samples, obtained from cancer patients or healthy donors. We show here that the three techniques yield results of the same order of magnitude. Although statistical analyses demonstrate significant differences between the three methods, these differences turned out to be clinically insignificant in most situations. Observed differences mostly affect samples with the highest content of CD34+ cells, while the three assays provide equivalent results for values that are close to clinically relevant thresholds (20 x 10(3) CD34+ cells/ml in peripheral blood to start apheresis, and accumulated number above 3 x 10(6) CD34+ cells/kg to stop apheresis). This study also supports the view that institutional protocols can provide a highly reliable determination of CD34+ cells counts and percentages. However, because institutional protocols often use research reagents and vary from institution to institution, the use of diagnostic kits may be prefered as one way to improve quality assurance in the practice of cell therapy.  (+info)

Superior autologous blood stem cell mobilization from dose-intensive cyclophosphamide, etoposide, cisplatin plus G-CSF than from less intensive chemotherapy regimens. (3/271)

The study purpose was to determine if G-CSF plus dose-intensive cyclophosphamide 5.25 g/m2, etoposide 1.05 g/m2 and cisplatin 105 mg/m2 (DICEP) results in superior autologous blood stem cell mobilization (BSCM) than less intensive chemotherapy. From January 1993 until May 1997, 152 consecutive patients with non-Hodgkin's lymphoma (n = 55), breast cancer (n = 47), Hodgkin's disease (n = 14), multiple myeloma (n = 9), AML (n = 9), or other cancers (n = 18) initially underwent BSCM by one of three methods: Group 1: G-CSF alone x 4 days (n = 30). Group 2: disease-oriented chemotherapy, dosed to avoid blood transfusions, followed by G-CSF starting day 7 or 8, and apheresis day 13 or 14 (n = 82). Group 3: DICEP days 1-3, G-CSF starting day 14, and apheresis planned day 19, 20 or 21 (n = 40). A multivariate analysis was performed to determine which factors independently predicted BSCM. The median peripheral blood CD34+ (PB CD34+) cell count the morning of apheresis linearly correlated with the number of CD34+ cells removed per litre of apheresis that day. The median PB CD34+ cell count and median CD34+ cells x 10(6) removed per litre of apheresis were highest for Group 3, intermediate for Group 2, and lowest for Group 1. By multivariate analysis, mobilization group (3 > 2 > 1), disease other than AML, no prior melphalan or mitomycin-C, and less than two prior chemotherapy regimens predicted better BSCM. Out of 15 Group 3 patients who had infiltrated marrows, 11 had no detectable cancer in marrow and apheresis products after DICEP. These data suggest that DICEP results in superior BSCM than less intensive chemotherapy regimens.  (+info)

Image-guided central venous catheters for apheresis. (4/271)

Apheresis is an increasingly important procedure in the treatment of a variety of conditions, sometimes performed via peripheral access because of concern over major complications associated with central venous catheter (CVC) placement. This study sought to determine the safety and success for ultrasound and fluoroscopically guided, non-tunneled dual lumen CVCs placed for apheresis. Prospective data collection was made of 200 attempted CVC placements in the radiology department utilizing real time sonographic guidance. The complications relating to placement were noted in all and the number of passes required for venepuncture and whether a single wall puncture was achieved was recorded in 185 cases. Duration of catheterization and reason for line removal were recorded in all. Our study group included 71 donors providing peripheral blood stem cells for allogeneic transplant. CVCs were successfully placed in all patients, 191 lines in the internal jugular and seven in the femoral vein. 86.5% required only a single pass and 80.5% with only anterior wall puncture. Inadvertent but clinically insignificant arterial puncture occurred in six (3%) cases. In no case did this prevent line placement. There were no other procedure-related complications. 173 (87.4%) catheters were removed the same day. No catheters were removed prematurely. There was one case of prolonged venous bleeding. Our study demonstrates the safety of central venous catheters for apheresis provided that duration of catheterization is short and real-time sonographic guidance is used for the puncture, and guide wire and catheter placement are confirmed fluoroscopically.  (+info)

Recombinant human thrombopoietin in combination with granulocyte colony-stimulating factor enhances mobilization of peripheral blood progenitor cells, increases peripheral blood platelet concentration, and accelerates hematopoietic recovery following high-dose chemotherapy. (5/271)

Lineage-specific growth factors mobilize peripheral blood progenitor cells (PBPC) and accelerate hematopoietic recovery after high-dose chemotherapy. Recombinant human thrombopoietin (rhTPO) may further increase the progenitor-cell content and regenerating potential of PBPC products. We evaluated the safety and activity of rhTPO as a PBPC mobilizer in combination with granulocyte colony-stimulating factor (G-CSF) in 29 breast cancer patients treated with high-dose chemotherapy followed by PBPC reinfusion. Initially, patients received escalating single doses of rhTPO intravenously (IV) at 0.6, 1.2, or 2.4 micrograms/kg, on day 1. Subsequent patients received rhTPO 0.6 or 0.3 micrograms/kg on days -3, -1, and 1, or 0.6 micrograms/kg on days -1 and 1. G-CSF, 5 micrograms/kg IV or subcutaneously (SC) twice daily, was started on day 3 and continued through aphereses. Twenty comparable, concurrently and identically treated patients (who were eligible and would have been treated on protocol but for the lack of study opening) mobilized with G-CSF alone served as comparisons. CD34(+) cell yields were substantially higher with the first apheresis following rhTPO and G-CSF versus G-CSF alone: 4.1 x 10(6)/kg (range, 1.3 to 17.6) versus 0.8 x 10(6)/ kg (range, 0.3 to 4.2), P =.0003. The targeted minimum yield of 3 x 10(6) CD34(+) cells/kg was procured following a single apheresis procedure in 61% of the rhTPO and G-CSF-mobilized group versus 10% of G-CSF-mobilized patients (P =.001). In rhTPO and G-CSF mobilized patients, granulocyte (day 8 v 9, P =.0001) and platelet recovery (day 9 v 10, P =.07) were accelerated, and fewer erythrocyte (3 v 4, P =.02) and platelet (4 v 5, P =.02) transfusions were needed compared with G-CSF-mobilized patients. Peripheral blood platelet counts, following rhTPO and G-CSF, were increased by greater than 100% and the platelet content of PBPC products by 60% to 110% on the first and second days of aphereses (P <.0001) with the greatest effect seen with repeated dosing of rhTPO at 0.6 microgram/kg. rhTPO is safe and well tolerated as a mobilizing agent before PBPC collection. Mobilization with rhTPO and G-CSF, in comparison to a comparable, nonrandomized G-CSF-mobilized group of patients, decreases the number of apheresis procedures required, may accelerate hematopoietic recovery, and may reduce the number of transfusions required following high-dose chemotherapy for breast cancer.  (+info)

Potential role for hyaluronan and the hyaluronan receptor RHAMM in mobilization and trafficking of hematopoietic progenitor cells. (6/271)

Although the mechanism(s) underlying mobilization of hematopoietic progenitor cells (HPCs) is unknown, detachment from the bone marrow (BM) microenvironment and motility are likely to play a role. This work analyzes the motile behavior of HPCs and the receptors involved. CD34(+)45(lo/med)Scatterlo/med HPCs from granulocyte colony-stimulating factor (G-CSF)-mobilized blood and mobilized BM were compared with steady-state BM for their ability to bind hyaluronan (HA), their expression of the HA receptors RHAMM and CD44, and their motogenic behavior. Although RHAMM and CD44 are expressed by mobilized blood HPCs, function blocking monoclonal antibodies (MoAbs) identified RHAMM as a major HA binding receptor, with a less consistent participation by CD44. Permeabilization of mobilized blood HPCs showed a pool of intracellular (ic) RHAMM and a smaller pool of icCD44. In contrast, steady-state BM HPCs have significantly larger pools of icRHAMM and icCD44. Also, in contrast to mobilized blood HPCs, for steady-state BM HPCs, MoAbs to RHAMM and CD44 act as agonists to upregulate HA binding. The comparison between mobilized and steady-state BM HPCs suggests that G-CSF mobilization is associated with depletion of intracellular stores of HA receptors and modulates HA receptor usage. To confirm that mobilization alters the HA receptor distribution and usage by HPCs, samples of BM were collected at the peak of G-CSF mobilization in parallel with mobilized blood samples. HA receptor distribution of mobilized BM HPCs was closely matched with mobilized blood HPCs and different from steady-state BM HPCs. Mobilized BM HPCs had lower pools of icHA receptors, similar to those of mobilized blood HPCs. Treatment of mobilized BM HPCs with anti-RHAMM MoAb decreased HA binding, in contrast to steady-state BM HPCs. Thus, G-CSF mobilization may stimulate an autocrine stimulatory loop for HPCs in which HA interacts with basal levels of RHAMM and/or CD44 to stimulate receptor recycling. Consistent with this, treatment of HPCs with azide, nystatin, or cytochalasin B increased HA binding, implicating an energy-dependent process involving lipid rafts and the cytoskeleton. Of the sorted HPCs, 66% were adherent and 27% were motile on fibronectin plus HA. HPC adherence was inhibited by MoAbs to beta1 integrin and CD44, but not to RHAMM, whereas HPC motility was inhibited by MoAb to RHAMM and beta1 integrin, but not to CD44. This finding suggests that RHAMM and CD44 play reciprocal roles in adhesion and motility by HPCs. The G-CSF-associated alterations in RHAMM distribution and the RHAMM-dependent motility of HPCs suggest a potential role for HA and RHAMM in trafficking of HPCs and the possible use of HA as a mobilizing agent in vivo.  (+info)

Autoaggression syndrome resembling acute graft-versus-host disease grade IV after autologous peripheral blood stem cell transplantation for breast cancer. (7/271)

Acute graft-versus-host disease (aGVHD) after autologous progenitor cell transplantation has been associated with blood transfusion or cyclosporine. Mild aGVHD grades I-II, identified as autoaggression or engraftment syndrome, has recently been described in autologous progenitor transplantation. Here, we report the first case of pathologically documented grade IV aGVHD after autologous peripheral blood progenitor cell transplantation in a patient with breast cancer. The allogeneic origin was excluded by molecular techniques, and no cyclosporine or cytokines were administered.  (+info)

Enrichment of peripheral blood CD34+ cells for transplantation using a fully automated immunomagnetic cell selection system and a novel octapeptide releasing agent. (8/271)

Positive selection of CD34+ cells is being increasingly performed to support hematological reconstitution following high-dose and dose-intensive chemotherapy and to reduce the non-target cell content of transplants. The present study was designed to evaluate the performance of an immunomagnetic cell selection system, including comparison of enzyme and peptide releasing agents and of semi-automated and fully automated selection systems. A total of 74 immunomagnetic CD34+ cell selection procedures were performed involving 55 subjects, the majority of whom had hematologic malignancies. Median CD34+ cell purity with a newly developed specific octapeptide releasing agent (98.5%; 81.0-99.0%) was significantly higher (P = 0.002) than that with chymopapain (85.8%; 28.1-99.7%). No significant differences were observed between semi-automated and fully automated systems in CD34+ cell purity or yield or time to WBC or platelet recovery. Immunomagnetic selection was found to provide highly purified populations of CD34+ cells in sufficient numbers for use in transplantation procedures. CD34+ cell transplants supported rapid and reliable hematologic reconstitution. Use of a fully automated system markedly reduced the time and labor required for immunomagnetic selection, potentially affording more standardized and reproducible positive selection of CD34+ cells.  (+info)

TY - JOUR. T1 - Immediate therapeutic efficacy of low-density lipoprotein apheresis for drug-resistant nephrotic syndrome. T2 - evidence from the short-term results from the POLARIS Study. AU - Muso, Eri. AU - Mune, Masatoshi. AU - Hirano, Tsutomu. AU - Hattori, Motoshi. AU - Kimura, Kenjiro. AU - Watanabe, Tsuyoshi. AU - Yokoyama, Hitoshi. AU - Sato, Hiroshi. AU - Uchida, Shunya. AU - Wada, Takashi. AU - Shoji, Tetsuo. AU - Yuzawa, Yukio. AU - Takemura, Tsukasa. AU - Sugiyama, Satoshi. AU - Nishizawa, Yoshiki. AU - Ogahara, Satoru. AU - Yorioka, Noriaki. AU - Sakai, Soichi. AU - Ogura, Yosuke. AU - Yukawa, Susumu. AU - Iino, Yasuhiko. AU - Imai, Enyu. AU - Matsuo, Seiichi. AU - Saito, Takao. PY - 2015/6/17. Y1 - 2015/6/17. N2 - Background: Hyperlipidemia is not merely a complication but a major exacerbating factor in longstanding nephrotic syndrome (NS). Low-density lipoprotein apheresis (LDL-A) has been reported to ameliorate dyslipidemia and induce rapid remission of NS. Several clinical ...
TY - JOUR. T1 - Alirocumab in patients with heterozygous familial hypercholesterolemia undergoing lipoprotein apheresis. T2 - Rationale and design of the ODYSSEY ESCAPE trial. AU - Moriarty, Patrick M.. AU - Parhofer, Klaus G.. AU - Babirak, Stephan P.. AU - Degoma, Emil. AU - Duell, P. Barton. AU - Hohenstein, Bernd. AU - Ramlow, Wolfgang. AU - Simha, Vinaya. AU - Steinhagen-Thiessen, Elisabeth. AU - Thompson, Paul D.. AU - Vogt, Anja. AU - Von Stritzky, Berndt. AU - Du, Yunling. AU - Manvelian, Garen. PY - 2016/5/1. Y1 - 2016/5/1. N2 - Background Many patients with heterozygous familial hypercholesterolemia (HeFH) fail to reach optimal low-density lipoprotein cholesterol (LDL-C) levels with available lipid-lowering medications, including statins, and require treatment using alternative methods such as lipoprotein apheresis. Objective To evaluate the efficacy of alirocumab 150 mg every 2 weeks (Q2W) compared with placebo in reducing the frequency of lipoprotein apheresis treatments in patients ...
Aengevaeren, Wim R.M. et al Low Density Lipoprotein Apheresis Improves Regional Myocardial Perfusion in Patients With Hypercholesterolemia and Extensive Coronary Artery Disease. Journal of the American College of Cardiology 28.7 (1996): 1696-1704. Web. 19 Feb. 2018. ...
To carry out in vitro research procedures on plasma or leukocyte components of whole blood, it is often necessary to obtain larger quantities of plasma or leukocytes than can be safely obtained by simple phlebotomy. These components can be easily and safely obtained using a well-established standard apheresis procedure that is in common use at the National Institutes of Health Apheresis Unit. This protocol describes the implementation of the same apheresis procedure at the National Blood Transfusion Center in Bamako, Mali. This is not a research protocol per se, but rather an adjunct protocol which allows healthy donors 18-55 years of age to undergo apheresis. Subjects must already be enrolled in another protocol which has been approved by the National Institute of Allergy and Infectious Diseases Institutional Review Board and the Faculty of Medicine, Pharmacy, and Odonto-Stomatology Ethics Committee ...
TY - JOUR. T1 - Associations among white blood cells, CD34+ cells and GM-CFU in predicting the optimal timing of peripheral blood stem cell collections by apheresis. AU - Boulassel, M. R.. PY - 2008/2. Y1 - 2008/2. N2 - Aims: To analyze preapheresis blood CD34+ cells and corresponding apheresis products in order to investigate whether peripheral blood CD34+ cell counts correlate with peripheral blood progenitor cell (PBPC) yields and to determine the optimal timing for starting PBPC collections in our clinical setting. Material and Methods: Thirty-eight patients with hematological malignancies and undergoing varied mobilization regimens were enrolled. White blood cell counts (WBC), CD34+ cells and granulocyte-macrophage colony-forming units (GM-CFU) enumeration were performed on blood samples taken immediately prior to each apheresis procedure and in the corresponding PBPC collection. Results: A total of 61 apheresis procedures were performed, with a median of two collections per patient (range ...
You are not able to breathe fully; you just take little breaths while you are dealing with something like this, said his father, Farrukh Farid, a co-owner of the Wallingford-based company, Edible Arrangements. After searching the Internet for answers, and traveling to hospitals in several states to talk to doctors, he was surprised to find that Dr. Mistry at YNHH had treated nine children in the United Kingdom with the same condition as his son. Two had been treated with transplants, and one of those had later married and had children. Farid considered LDL (low-density lipoprotein) apheresis treatment for his son at Johns Hopkins Medical Center and also visited homeopathic and herbal specialists in Dubai and Southeast Asia, but he believed that a liver transplant was the best solution. The Farids expected to wait at least a year for a liver donation. Farrukh was surprised three months later when the phone rang while he was home playing with his son.. When I got the call, time stood still for ...
LDL apheresis, a potent therapeutic modality that removes cholesterol within several hours, has been reported to increase the skeletal muscle blood flow when repeated for 3 weeks.26 In the present study, we first demonstrated that a single session of LDL apheresis improved acetylcholine-induced endothelium-dependent vasodilatation associated with the reduction in plasma LDL cholesterol. This observation supports the concept that hypercholesterolemia causes endothelial dysfunction and indicates that short-term correction of hypercholesterolemia could restore endothelial function.. Although the precise mechanisms of amelioration of endothelium-dependent vasodilatation by lipid-lowering therapy remain to be elucidated, several possibilities have been suggested: (1) improvement of endothelium-derived relaxing factor (EDRF) production, (2) decrease in the inactivating factors of EDRF, (3) decrease in the endothelium-derived contracting factors, (4) regression of the diffusional barrier for EDRF, (5) ...
The global apheresis equipment market is expected to reach USD 3.7 billion by 2024, according to a new report by Grand View Research, Inc. The apheresis equipment industry is expected to be impacted by factors such as rising demand for plasma, platelets and other blood components, increasing incidence of chronic illnesses, presence and development of ideal reimbursement policies across various regions, and supportive government initiatives.. The U.S. Federal Government has been very involved in the funding of apheresis research through its benefit programs such as Medicare, Medicaid, veterans health administration military and employee insurance programs. Medicare provides coverage for apheresis regardless of whether the procedure is performed in a hospital or a blood center. In addition, private insurers have recently begun to closely examine apheresis procedures and issue policy statements pertaining to coverage.. Growing incidence of blood related disorders leading to the rise in demand for ...
Preventive Cardiology Inc. is the only practice in South Florida for B. Brauns LDL Apheresis treatment. Call today to learn more!
10. Taseva K, Fischer S, Passauer J, Weiss N, Bornstein SR, Julius U (2013) Factors inducing cardiovascular events in patients treated by lipoprotein apheresis. Atherosclerosis Supplements 14:51-55.. 11. Tselmin S, Rodionov RN, Müller G, Bornstein S, Julius U (2013) Homocysteine in lipoprotein apheresis in patients - Retrospective data analysis in apheresis center of a university hospital. Atherosclerosis Supplements 14:123-128.. 12. Giugliano RP, Ruff CT, Braunwald E, Murphy SA, Wiviott SD, Halperin JL, Waldo AL, Ezekowitz MD, Weitz JI, Spinar J, Ruzyloo W, Ruda M, Koretsune Y, Betcher J, Shi M, Grip LT, Patel SP, Patel I, Hanyok JJ, Mercuri M, Antmann EM, ENGAGE AF-TIMI 48 Investigators (2013) Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 369:2093-2104.. 13. Kucher N, Boekstegers P, Müller O, Kupatt C, Beyer-Westendorf J, Heitzer T, Tebbe U, Horstkotte J, Müller R, Blessing E, Greif M, Lange P, Hoffmann RT, Werth S, Bameyer A, Härtel D, Grünwald H, Empen K, ...
The Division also provides 24-hour consultation, execution, and monitoring of therapeutic apheresis procedures to all UCD clinical services, as well as other health systems in the greater Sacramento area. Therapies include plasma exchange, red cell exchange, leukoreduction and platelet reduction in addition to photopheresis. Members of the division are also involved in clinical apheresis research.. In addition to contributing to the professional development of the transfusion medicine fellow, members of the apheresis faculty are involved in teaching pathology residents and other medical trainees in the clinical applications and appropriate use of this specialized therapeutic modality.. Contact Apheresis Services at 916-734-3732.. ...
Protocol Design: This protocol is designed to perform collection of human specimens, such as blood, mucosal secretions, skin swabs, skin biopsy, or body fluids to support research studies. These samples will be used by laboratory researches in their work on the development of vaccines for HIV and other infectious diseases, to study the correlates of immunity related to infectious diseases and in laboratory work related to the development and/or validation of immunological assays.. In order to carry out research studies, it is often necessary to obtain larger quantities of plasma or mononuclea cells than can be safely obtained by simple phlebotomy. These components can be safely obtained using apheresis procedures in the Apheresis Clinic of the Clinical Center Department of Transfusion Medicine (DTM). The aphereses performed through this protocol conform to the requirements of the DTM Apheresis Clinic.. Subjects: Volunteers, at least 18 years old, (including participants in other NIH research ...
The TheraSorb® LDL therapy system consists of two reusable adsorbers, available in different sizes, that remove LDL cholesterol, Lp(a) and VLDL from the patient´s blood. The sepharose volume constituting the adsorbers is 100 mL for the LDL pro adsorber and 200 mL for the LDL adsorber. The plasma volumes processed during an LDL apheresis treatment can be adjusted to the patient´s need. Between the treatments, both adsorbers are stored in a preservation solution and must be kept at 2-8 °C. Up to 20 treatments can be performed with a single pair of either LDL pro or LDL adsorbers for one patient. The treatment is well tolerated due to the low bradykinin release, which otherwise can cause severe hypotension. Furthermore, the low extracorporeal volume of about 180 mL allows for the treatment of patients with a low body weight in double-needle mode. TheraSorb LDL removal is a highly selective procedure. - Suomi
One more dose collected may mean one more patient treated, one more person saved, or one more life renewed. Thats why more matters. And its why the Fresenius Kabi Amicus Separator is designed to help you increase your inventory of platelets, plasma, and red cells. Enhance the efficiency of your apheresis procedure, and expand the impact of your donors. ...
A pre-attached subassembly component of an apheresis kit for apheresis kit priming and/or for use as a replenishment fluid to maintain isovolemia in subjects undergoing an apheresis procedure.
It has been reported that an intensive, two GMA session per week produced a higher remission rate and in a shorter time as compared with one GMA session per week in patients with active UC [24]. In this study, we found that intensive GMA as two sessions per week, up to 10 sessions and weekly GMA, up to 10 sessions were associated with similar remission rates in patients with active CD, but time to remission was significantly better with the former as compared with the latter. The mean time to remission was 5 weeks in the weekly GMA vs 3 weeks in the intensive GMA. The obvious difference between the two treatment frequencies appears to be shortening of morbidity time by intensive GMA.. Dignass et al. compared 5 and 10 GMA apheresis treatments in steroid-refractory or steroid-dependent UC patients, and reported that 5 GMA sessions were not inferior to 10 sessions [26]. In their study protocol, patients received 5 GMA treatments, once a week over 5 consecutive weeks, or 10 treatments, twice weekly ...
Waldmann, Elisa; Vogt, Anja; Crispin, Alexander; Altenhofer, Julia; Riks, Ina und Parhofer, Klaus G. (2017): Effect of mipomersen on LDL-cholesterol in patients with severe LDL-hypercholesterolaemia and atherosclerosis treated by lipoprotein apheresis (The MICA-Study). In: Atherosclerosis, Vol. 259: S. 20-25 ...
Low-density lipoprotein (LDL) cholesterol apheresis is an effective treatment in lowering LDL cholesterol, improving clinical endpoints, and lowering lipop
I thank God every day for my good health and so I feel that if by being an apheresis donor I can help someone in need of platelets. I must do my part. It is always a very pleasant experience when I visit the Eastern Hills site. Everyone there is cheerful and they always make me feel like I am appreciated for taking the time to give. They are a wonderful group.. ...
Lipid apheresis removes LDL cholesterol and other factors of arteriosclerosis, such as lipoprotein(a) and triglycerides from the blood - among other things in case of severe fat metabolism disorders. It is particularly suitable for patients who do not react to treatment by special diet and medicines to reduce their LDL cholesterol, or do not react sufficiently to this.. ...
Preventive Cardiology Inc. provides comprehensive treatment for cardiovascular disease and looks to prevent heart disease. Visit our website for more info!
The Apheresis Center at the Mount Sinai Health System provides therapeutic apheresis (TA) and peripheral blood stem cell (PBSC) collection services.
Apparatus for carrying out therapeutic apheresis includes a filter device for being implanted in a blood vessel for carrying out in-vivo plasma separation having one or more elongated hollow tubes and a plurality of elongated hollow microporous fibers capable of separating plasma from whole blood at pressure and blood flow within a patients vein, a multiple lumen catheter secured to the proximal end of the filter device having one or more lumens in fluid communication with the interior of said one or more hollow tubes and a plasma return lumen, and therapeutic apheresis apparatus for removing and/or separating selected disease-related components from the separated plasma and means for directing plasma between said catheter and the selective component removal apparatus.
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Therapeutic apheresis plays a significant role in the treatment of many diseases, as well as, the research of cutting-edge therapies.
Transition from your COBE Spectra Apheresis System to the Spectra Optia Apheresis System: our team of experts is standing by and ready to help make the transition smooth and set you up with the right training that works best for your team.
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TY - JOUR. T1 - Rationale and study design of a clinical trial to assess the effects of LDL apheresis on proteinuria in diabetic patients with severe proteinuria and dyslipidemia. AU - Wada, Takashi. AU - Muso, Eri. AU - Maruyama, Shoichi. AU - Hara, Akinori. AU - Furuichi, Kengo. AU - Yoshimura, Kenichi. AU - Miyazaki, Mariko. AU - Sato, Eiichi. AU - Abe, Masanori. AU - Shibagaki, Yugo. AU - Narita, Ichiei. AU - Yokoyama, Hitoshi. AU - Mori, Noriko. AU - Yuzawa, Yukio. AU - Matsubara, Takeshi. AU - Tsukamoto, Tatsuo. AU - Wada, Jun. AU - Ito, Takafumi. AU - Masutani, Kosuke. AU - Tsuruya, Kazuhiko. AU - Fujimoto, Shoichi. AU - Tsuda, Akihiro. AU - Suzuki, Hitoshi. AU - Kasuno, Kenji. AU - Terada, Yoshio. AU - Nakata, Takeshi. AU - Iino, Noriaki. AU - Kobayashi, Shuzo. N1 - Publisher Copyright: © 2017, Japanese Society of Nephrology. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 2018/6/1. Y1 - 2018/6/1. N2 - Background: Diabetic nephropathy is a leading cause of end-stage ...
Familial hypercholesterolemia is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein, in the blood and early cardiovascular disease. Homozygous Familial Hypercholesterolemia (HoFH) is a rare, but very severe form of an inherited disorder resulting from a genetic mutation on chromosome number 19. This mutation makes the liver incapable of metabolizing cholesterol, specifically low-density lipoprotein (LDL), resulting in very high LDL levels. The disorder leads to aggressive atherosclerosis, which if left untreated, causes individuals to experience heart attacks or death before age 30. Many patients with homozygous FH must undergo LDL apheresis on a regular basis. LDL Apheresis is a process by which blood is removed, LDL-C is filtered out, and then the persons blood is returned to their body. It is similar to dialysis. This form of familial hypercholesterolemia occurs in about 1 in 160,000 to one million people worldwide.. ...
Anaphylactoid Reactions: Sudden and potentially life-threatening anaphylactoid reactions have occurred in some patients dialyzed with high-flux membranes treated concomitantly with an ACE inhibitor. In such patients, dialysis must be stopped immediately, and aggressive therapy for anaphylactoid reactions must be initiated. Symptoms have not been relieved by antihistamines in these situations. In these patients, consideration should be given to using a different type of dialysis membrane or a different class of antihypertensive agent. Anaphylactoid reactions have also been reported in patients undergoing low-density lipoprotein apheresis with dextran sulfate absorption and in patients undergoing desensitizing treatment with hymenoptera venom ...
Lipid apheresis effectively lowers LDL-cholesterol even in drug-unresponsive severely hypercholesterolemic patients. This results in improvement of symptoms of coronary artery disease, reduces progression of coronary atherosclerosis, and decreases coronary event rates. Besides aggressive lipid lowering itself, these effects may also be due to nonselective removal of other high molecular weight proteins leading to improved hemorheology. Lipid apheresis is also used for treating symptoms of vascular diseases outside the coronary arteries, such as peripheral arterial disease and the angioneuropathic diabetic foot syndrome. This review discusses putative effects of lipid apheresis and rheophereis on restoring pathophysiological processes involved in the development of symptoms of peripheral arterial disease, critical limb ischemia, and the diabetic foot syndrome. The clinical experience with lipid apheresis and rheopheresis in treating patients with peripheral arterial disease and the diabetic foot syndrome
Low-density lipoprotein (LDL) is the major cholesterol carrying lipoprotein in your blood. LDL apheresis is a procedure that takes blood outside the body to remove the LDL-cholesterol and then returns the plasma and blood back to the body. This procedure is used if diet or lipid-lowering drug therapy has not lowered high LDL-cholesterol levels adequately.. Dr. Amale Lteif evaluates patients who might e candidates for LDDL apheresis and overseas this procedure which is performed at Spring Mill Indiana University Infusion Center using the LIPOSORBER system.. ...
HELP LDL Apheresis Reduces Plasma Pentraxin 3 in Familial Hypercholesterolemia. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
VA Balashova, VI Rugal, SS Bessmeltsev, SV Gritsaev, NYu Semenova, SV Voloshin, ZhV Chubukina, AV Shmidt, AD Garifullin, IM Zapreeva, AA Kuzyaeva, II Kostroma, AYu Kuvshinov, AV Chechetkin Russian Research Institute of Hematology and Transfusiology, 16 2-ya Sovetskaya str., Saint Petersburg, Russian Federation, 191024 For correspondence: Valentina Andreevna Balashova, MD, PhD, 16 2-ya Sovetskaya str., Saint Petersburg, Russian Federation, 191024; Tel.: +7(812)717-19-37; e-mail: [email protected] For citation: Balashova VA, Rugal VI, Bessmeltsev SS, et al. Correlation of CD34+ Hematopoietic Stem Cells and CFU in Peripheral Blood Apheresis Products in Patients with Malignant Lymphoproliferative Diseases Before and After Cryopreservation Prior to auto-HSCT. Clinical oncohematology. 2018;11(4):368-77. DOI: 10.21320/2500-2139-2018-11-4-368-377 ABSTRACT Aim. To establish correlation between CD34+ autologous hematopoietic stem cell (HSC) count and colony-forming units (CFU) in the same peripheral blood
Lipoprotein-apheresis (apheresis) removes LDL-cholesterol in patients with severe dyslipidemia. However, reduction is transient, indicating that the long-term cardiovascular benefits of apheresis may not solely be due to LDL removal. Microparticles (MPs) are submicron vesicles released from the plasma membrane of cells. MPs, particularly platelet-derived MPs, are increasingly being linked to the pathogenesis of many diseases. We aimed to characterize the effect of apheresis on MP size, concentration, cellular origin, and fatty acid concentration in individuals with familial hypercholesterolemia (FH). Plasma and MP samples were collected from 12 individuals with FH undergoing routine apheresis. Tunable resistive pulse sensing (np200) and nanoparticle tracking analysis measured a fall in MP concentration (33 and 15%, respectively; P , 0.05) pre- to post-apheresis. Flow cytometry showed MPs were predominantly annexin V positive and of platelet (CD41) origin both pre- (88.9%) and post-apheresis ...
The American Society for Apheresis (ASFA) has issued updated recommendations on the use of therapeutic apheresis in clinical practice. Published in the Sixth Edition of the ASFA Special Issue, these evidence-based guidelines were developed by a committee of United States-based experts from transfusion medicine/apheresis, hematology/oncology, nephrology, and other relevant fields. The updated guidelines include 78 diseases, each of which was assigned an indication category (I-IV) describing the role of apheresis therapy and a grade of recommendation (1A-2C) based on the quality of evidence available.. Reference. 1. Schwartz J, Winters JL, Padmanabhan A, Balogun RA, Delaney M, Linenberger ML, Szczepiorkowski ZM, Williams ME, Wu Y, Shaz BH. Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the writing committee of the american society for apheresis: the sixth special issue. J Clin Apher 2013;28: 145-284.. ...
LIFE 18™ - Theraline pro is a tubing set for all adsorption treatments with the LIFE 18 apheresis unit. It comprises the pump cassette and tubing lines to connect the patient, the separator, the appropriate adsorbers, and the system solutions with each other. it is a sterile, single-use disposable. Two chambers are integrated as reservoirs into the pump cassette to enable a
This method of platelet collection takes two hours and is performed through an automated process called plateletpheresis.. During the collection, the donors blood flows through the tubing into the apheresis instrument. Through centrifugation, the apheresis instrument extracts only the donors platelets which are collected in a sterile bag. The rest of the blood flows back through the tubing to the donor.. This is a sterile procedure, and the disposable materials are only used once before being discarded.. For your ultimate comfort, the donation by apheresis is carried out under the constant supervision of a nurse. ...
Though you earned a built-in bloodstream transfusion it may be crucial to wait around yr. Refreshing donors can begin donating bloodstream utilizing their 16th birthday up utilizing their 66th birthday. Presented then they meet apheresis donor selection wants and also have described a minimum of one entire bloodstream donation in the previous 2 yrs, existing entire bloodstream donors are currently eligible to begin donating simply by apheresis utilizing their 18th utilizing their 61st birthday. Should the anaemia is being treated successfully combined with the finger prick experiment finished before now serving bloodstream suggests that your bodys haemoglobin will become from your logical scale, on you are likely to donate. Herpes - Ive vaginal herpes. Whether it be someone who is definitely HIV-positive donates arteries devices, as with that an body organ or tissues, yet the one who receives yet the arteries health supplement tends to create that an HIV contamination as well. In order to ... Further key findings from the study suggest:. Neurology dominated the application market in terms of share at over 50.2% in 2013, due to increasing prevalence of blood disorder, plasma exchange due to growing rates of multiple sclerosis majority in the U.S.. Membrane filtration was the most dominant technology in the apheresis market, with revenue estimated at over USD 805.9 million in 2013. Centrifugation is expected to grow at the highest CAGR of 12.6% from 2014 to 2020. It finds usage in the apheresis of any blood component and is not restricted to plasma exchange as membrane filtration.. North America was the largest regional market in 2013, accounting for over 48.5% of global revenue due to the presence of high patient awareness levels, healthcare expenditure and sophisticated healthcare infrastructure.. Asia Pacific expected to grow at the fastest CAGR of 13.5% from 2014 to 2020. Large presence of unmet medical needs ...
Includes five uniform unlabeled microbead populations, used to construct calibration plots for electronic volume and light scatter instrumentation.
The process of removing components of a patients or donors blood and returning the unneeded parts. This process makes it possible to remove desired elements from large volumes of blood. Platelets, red cells, white cells, stem cells, or plasma can be removed separately. Apheresis can also be used to remove undesirable elements from the blood.. Tags: A, Cancer Dictionary, Uncategorized. ...
The worldwide Apheresis Equipment Market is anticipated to expand remarkably over the forecast period (2012 to 2020). In 2015, the industry generated reven
In this study, the in vitro and in vivo antitumor properties of the IL-2-activated MNCs from UCBCs in comparison with IL-2-activated MNCs from PBCs were explored. The NK cytotoxicity levels of UCBCs were very low compared with PBCs prior to in vitro activation (data not shown). After IL-2 activation, however, there was significant antitumor cytotoxicity against NK-sensitive/LAK-resistant and LAK-sensitive tumor target cells (Fig. 1)⇓ . Similar results have been observed by other investigators (20, 21, 22, 23, 24, 25, 26) . The activated UCBCs were not only cytotoxic to hematological malignant cells but also considerably cytotoxic to human breast cancer cells (Fig. 2)⇓ . The level of cytotoxicity of activated cord blood cells against breast cancer was not different from that of similarly activated MNCs from peripheral blood apheresis product. This result is different from what we observed with K562 and Raji tumor targets. The precise reason for this difference is not clear at this ...
I was an apheresis technician for about five years during nursing school. I have tons of donor experience collecting whole blood, platelets and granulocytes, but I have (very) limited therapeutic
During an apheresis donation1, an anticoagulant is added to the blood to prevent it from clotting once outside the body.. Depending on the type of donation you make, fluids may also be administered to you during the blood collection. ...
Learn about the different Apheresis procedures available at Inova including Extracorporeal Photopheresis (ECP), Leukapheresis (White Blood Cell Depletion), Plasmapheresis (Therapeutic Plasma Exchange), Plateletpheresis (Platelet Depletion), Red Blood Cell (RBC) Exchange and Therapeutic Phlebotomy.
BACKGROUND/AIMS: Peripheral blood stem cells (PBSC) are one of the most promising stem cell sources for treatment of ischaemic heart disease. However, the experience of mobilisation and collection of PBSC using granulocyte-colony stimulating factor (G-CSF) in patients with myocardial infarction (MI) is still limited. We report our experiences with the feasibility and safety of collection of mobilised PBSC with G-CSF in MI patients, and the influence of acute ischaemia on efficacy of PBSC collection.. METHODS: 74 patients with acute or old myocardial infarction (AMI vs OMI, n = 46 and n = 28) underwent PBSC collection after administration of G-CSF twice a day at a dose of 5 microg/kg for 3 days. Flow cytometric analysis of cell surface markers was performed.. RESULTS: No evidence of inflammation or ischaemia was observed during G-CSF mobilisation and PBSC collection. The yield of CD34(+) cells was 12.9 (SD 15.92) x10(9)/l (5.04% (5.30%) of total cells) with a product volume of 37.9 (8.4) ml after ...
Apheresis platelets contain significant amounts of free PDGF, TGF-β, and VEGF in the plasma on day 1 of storage, presumably as a function of the apheresis techniques employed for isolation of a concentrated product, compared with fresh plasma isolated from whole blood drawn directly into a heparinized tube from healthy controls, which included the platelet donors. These data should not be compared with serum levels of these growth factors, which would be released during the cellular (platelet) phase of clotting resulting in much higher levels of these factors compared with plasma (25-30). Importantly, healthy donors do not have significantly increased amounts of VEGF, TGF-β, PDGF, or FGF-2 in their plasma, and the presented data support this previous work (25, 30). These concentrations increased progressively during the storage interval, showing significant accumulation in the plasma fraction compared with the previous day, and reached a relative maximum at component outdate (day 5 or 7). In ...
An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.
This study will investigate the efficacy and tolerability of bortezomib + cyclophosphamide + filgrastim or lenograstim in patients with multiple myeloma. The
The study covers current and future market trends, drivers, challenges, and opportunities in US therapeutic apheresis market. It breaks down the market into hematology and oncology, neurology, rheumatology, and other therapeutic areas. Therapeutic apheresis has become an essential element of the blood and blood components industry value chain. Hospitals are the primary users of apheresis equipment and solutions; other users include blood banks and dialysis centers. End users include therapeutic apheresis nurses, referring physicians, hematologists, oncologists, rheumatologists, neurologists, nephrologists, cardiologists, and lipidologists. The study covers standard plasmapheresis or plasma exchange, extracorporeal immunoadsorption, plateletpheresis, red cell exchange, leukapheresis, and lipidpheresis. The two broad product categories are devices and disposables. The study discusses key trends that are expected to impact the market, including more applications across different therapeutics segments and
The study covers current and future market trends, drivers, challenges, and opportunities in US therapeutic apheresis market. It breaks down the market into hematology and oncology, neurology, rheumatology, and other therapeutic areas. Therapeutic apheresis has become an essential element of the blood and blood components industry value chain. Hospitals are the primary users of apheresis equipment and solutions; other users include blood banks and dialysis centers. End users include therapeutic apheresis nurses, referring physicians, hematologists, oncologists, rheumatologists, neurologists, nephrologists, cardiologists, and lipidologists. The study covers standard plasmapheresis or plasma exchange, extracorporeal immunoadsorption, plateletpheresis, red cell exchange, leukapheresis, and lipidpheresis. The two broad product categories are devices and disposables. The study discusses key trends that are expected to impact the market, including more applications across different therapeutics segments and
Background: Surgical bypass techniques and percutaneous catheter-based interventions may be used to successfully revascularize the limbs of patients with claudication. In many patients, however, the anatomic extent and distribution of arterial occlusion is too severe to permit relief of pain. Limited medical therapy is available for these pts.. Methods: A phase IIa randomized, double-blind, placebo-controlled clinical trial of autologous CD34+ stem cell (CD34) therapy was performed in pts with Rutherford class 3 at 3 centers in US. 3 treatment groups: placebo, low (1x10^5 CD34/kg body wt) and high dose (1x10^6 CD34/kg). All pts underwent mobilization with GCSF 5 mcg/kg/day SC for 5 d, followed by apheresis on d5 followed by selection for CD34 with Isolex 300i device. CD34 were injected IM at 8 locations in the ischemic limb. Placebo injections consisted of identical volumes of the diluent only.. Results: A total of 17 pts have been randomized, completed the injection procedure and completed the ...
TY - JOUR. T1 - Intermittent Granulocyte and Monocyte Apheresis Versus Mercaptopurine for Maintaining Remission of Ulcerative Colitis. T2 - A Pilot Study. AU - Sakuraba, Atsushi. AU - Sato, Toshiro. AU - Morohoshi, Yuichi. AU - Matsuoka, Katsuyoshi. AU - Okamoto, Susumu. AU - Inoue, Nagamu. AU - Takaishi, Hiromasa. AU - Ogata, Haruhiko. AU - Iwao, Yasushi. AU - Hibi, Toshifumi. PY - 2012/6. Y1 - 2012/6. N2 - The effect of granulocyte and monocyte adsorption apheresis (GMA) on prevention of relapse of ulcerative colitis (UC) is not clear. This was a pilot open-labeled, prospective, randomized, unblinded study to compare the tolerability and efficacy of intermittent GMA (once every 2weeks) with mercaptopurine to maintain remission of UC. Twenty-one patients with UC, who had achieved remission by induction therapies were randomly assigned to receive either intermittent GMA (N=10) or oral mercaptopurine (0.5mg/kg per day; N=11). The study period was 24months. The rate of the patients maintaining ...
The efficiency and efficacy of low-density lipoprotein (LDL) apheresis performed with a dextran sulphate cellulose (DSC) regenerating unit were tested in five familial hypercholesterolaemic patients. LDL apheresis was repeated four times at both bi-weekly and weekly intervals, processing one plasma volume each time. The efficiency of the procedure (i.e., the extent of lipoprotein removal) was nearly identical with both schedules. Efficacy parameters, i.e., decreases of plasma total and LDL cholesterol (TC and LDL-C) and apo B, were highly correlated (r , 0.96) with pre-apheresis levels, allowing an accurate prediction of the absolute lipid removal in the single individual. Plasma triglycerides, high-density lipoprotein cholesterol, apo A-I and apo A-II recovered rather rapidly, reaching 91-96% of the pre-apheresis values in 48 hours; the recovery of TC, LDL-C and apo B was much slower, with a relatively rapid early phase (80% recovery after about 7 days) followed by a successive slower rise. ...
Spieker, L E; Flammer, A J; Amacker, N; Sudano, I; Badimon, J J; Ruschitzka, F; Luscher, T F; Noll, G; Corti, R (2006). C-reactive protein influences shear stress-dependent platelet adhesion in patients with familiar hypercholesterolemia and coronary artery disease undergoing LDL apheresis. Thrombosis and Haemostasis, 96(4):540-542.. Sudano, I; Spieker, L E; Noll, G; Corti, R; Weber, R; Lüscher, T F (2006). Cardiovascular disease in HIV infection. American Heart Journal, 151(6):1147-1155.. Hermann, F; Spieker, L E; Ruschitzka, F; Sudano, I; Hermann, M; Binggeli, C; Lüscher, T F; Riesen, W; Noll, G; Corti, R (2006). Dark chocolate improves endothelial and platelet function. Heart, 92(1):119-120.. Sudano, I; Spieker, L E; Hermann, F; Flammer, A; Corti, R; Noll, G; Luscher, T F (2006). Protection of endothelial function: targets for nutritional and pharmacological interventions. Journal of Cardiovascular Pharmacology, 47 Sup:S136-S150.. Spieker, L E; Ruschitzka, F; Lüscher, T F; Noll, G (2004). ...
The findings presented at EAS highlight mipomersens potential to treat the unique needs of patients with severe forms of FH, said Vice President and General Manager of Genzymes Cardiovascular Business, Paula Soteropoulos. Other than apheresis, there is no approved treatment that addresses the specific challenges faced by severe FH patients, which include elevated Lp(a) in addition to LDL-C. We believe mipomersen could play an important role as a targeted treatment for these patients. In a presentation entitled Mipomersen, an ApoB Synthesis Inhibitor, Might Reduce Necessity for Lipid Apheresis in CAD, K.G. Parhofer, M.D., of Ludwig-Maximilians University, Munich, Germany, focused on mipomersens potential to reduce the necessity for lipid-apheresis by lowering LDL-C values below thresholds for apheresis eligibility. Patients with severe forms of FH may be eligible for this treatment, a dialysis-like procedure where blood is filtered through a machine to remove excess cholesterol. ...
Product Synopsis 2015 Global Apheresis Equipment Industry Report is a professional and in-depth research report on the worlds major regional market
Another method of separating blood is through apheresis. During this procedure, blood is drawn from a donor in the same way as a routine blood donation, however instead of being collected in a bag, the blood travels via tubing to a machine where the components are separated. The machine will separate the components using either the centrifuge process where the inside of the machine spins like a centrifuge or by filtration using a series of micro filters to separate components by size. After the desired components are collected the blood travels back through the tubing and is reinfused into the donor. Apheresis may be used on patients who exhibit severe symptoms of a disease and removing the constituent helps the symptoms. However this process must be done fairly frequently and is usually used as a last resort, after other methods to control the symptoms have failed ...
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Just a quick hello for the most recent treatment developments. We returned to hospital this week for a procedure which is called a stem-cell harvest. (Apheresis) Essentially, Gavin is given a drug that forces his bone-marrow to produce so many new stem-cells that they are forced into his bloodstream, and are then collected from there […]. ...
We offer a variety of eLearning courses that will sharpen your knowledge of therapeutic apheresis, cell therapy and blood bank technology. Our eLearning programs address key terminology, concepts and principles related to our products and your work.
Component (usually about 98%) of some tree stump removal products. It accelerates the natural decomposition of the stump by ... Combats high blood pressure and was once used as a hypotensive. Electrolyte in a salt bridge Active ingredient of condensed ... Stan Roark (February 27, 2008). "Stump Removal for Homeowners". Alabama Cooperative Extension System. Archived from the ... tree stump removal, rocket propellants and fireworks. It is one of the major constituents of gunpowder (black powder). In ...
"Removal of the skin blood flow artifact in functional near-infrared spectroscopic imaging data through independent component ... Since the short separation channels measure the signal coming from the scalp, they allow the removal of the signal of ... Different fNIRS techniques can also use the way in which light propagates to estimate blood volume and oxygenation. The ... Through neuro-vascular coupling, neuronal activity is linked to related changes in localized cerebral blood flow. fNIRS and ...
... blood cells and plasma. The blood plasma components, such as the antibodies, are treated outside of the body. After removal of ... Corticosteroids cause white blood cell death, lowering their numbers throughout the body. They also cause white blood cells to ... Examination of the fundus (inner surface of eye) can show no results or it can show narrowing of the blood vessels, abnormal ... Instead of treating the plasma and blood cells, they are replaced with a healthy donor mixture. Patients who respond positively ...
... (Aβ or Abeta) denotes peptides of 36-43 amino acids that are the main component of the amyloid plaques found in ... Aβ can also form the deposits that line cerebral blood vessels in cerebral amyloid angiopathy. The plaques are composed of a ... and presequence protease The rate of removal is significantly increased during sleep. However, the significance of the ... It is an arginase inhibitor which readily crosses the blood brain barrier, and reduces arginine loss in the brain. Amyloid beta ...
Cases of very high blood pressure are treated with medications that relieve anxiety and relax the blood vessels. Scorpion ... One fluorescent component is beta-carboline. Accordingly, a hand-held ultraviolet lamp has long been a standard tool for ... They excrete insoluble compounds such as xanthine, guanine, and uric acid, not requiring water for their removal from the body ... Sinuses return deoxygenated blood or hemolymph to the heart; the hemolymph is re-oxygenated by cardiac pores. The mesosoma also ...
... nerves and blood vessels are present in the dermis. Those blood vessels provide nourishment and waste removal for both dermal ... Structural components of the dermis are collagen, elastic fibers, and extrafibrillar matrix. It also contains mechanoreceptors ... Within the reticular region are the roots of the hair, sebaceous glands, sweat glands, receptors, nails, and blood vessels. The ... Apart from these cells, the dermis is also composed of matrix components such as collagen (which provides strength), elastin ( ...
... is the removal of white blood cells (or leukocytes) from the blood or blood components supplied for blood ... of red blood cells from a processed unit of Red Blood Cells. Because blood from persons who possess the sickle cell mutation is ... defined as the routine application of this blood-processing step to all units of whole blood, red blood cells, and platelets ... After the removal of the leukocytes, the blood product is said to be leukoreduced. It is theorized that transfusions that ...
Citric and oxalic acids are used as rust removal. As acids, they can dissolve the iron oxides, but without damaging the base ... Human blood and urine contain these plus organic acid degradation products of amino acids, neurotransmitters, and intestinal ... bacterial action on food components. Examples of these categories are alpha-ketoisocaproic, vanilmandelic, and D-lactic acids, ... In the dissociated form, they may be able to chelate the metal ions, helping to speed removal. Biological systems create many ...
Blood sugars are the primary glutamate removal method from inter-synaptic spaces at the NMDA and AMPA receptor site. Persons in ... These enzymes go on to damage cell structures such as components of the cytoskeleton, membrane, and DNA. ... in which blood flow is reduced to inadequate levels. Ischemia is followed by accumulation of glutamate and aspartate in the ...
Component (usually about 98%) of some tree stump removal products. It accelerates the natural decomposition of the stump by ... Combats high blood pressure and was once used as a hypotensive.[43] ... Major uses of potassium nitrate are in fertilizers, tree stump removal, rocket propellants and fireworks. It is one of the ... "Stump Removal for Homeowners". Alabama Cooperative Extension System. Archived from the original on March 23, 2012. ...
... therapy with special cells and blood components 8-90...8-91: anesthesia and pain management 8-92...8-93: patient monitoring 8- ... removal of foreign material and debris 8-12...8-13: manipulation of digestive tract and urinary tract 8-14...8-17: Therapeutic ... Operations on the blood vessels (vascular surgery) 5-40...5-41: Operations on the hematopoietic and lymphatic system 5-42...5- ...
The average removal rate is 250 milliliter (1/2 pint) per hour. The fluid removed is isotonic to blood and therefore ... Aquapheresis therapy is delivered by three basic components: a console (the machine with two pumps), the blood filter circuit, ... The blood is outside the body for less than a minute and the total amount of blood is 33 milliliters (2.5 tablespoons). It is ... Using a form of ultrafiltration, the filter separates the excess salt and water from the blood and the blood is returned to the ...
Carbon dioxide is more readily dissolved in deoxygenated blood, facilitating its removal from the body after the oxygen has ... is formed during physiological respiration when oxygen binds to the heme component of the protein hemoglobin in red blood cells ... Because the reaction is slow, the Hb A1c proportion represents glucose level in blood averaged over the half-life of red blood ... Increased levels of this chemical are detected in the blood if red blood cells are being destroyed more rapidly than usual. ...
A surgical drain is often left in the pelvis for several days to allow drainage of blood and other fluid. Additional components ... Removal of select lymph nodes in the pelvis allows microscopic evaluation for evidence of cancer within these nodes. A ... The blood vessels leading to and from the prostate are divided and tied off. Recovery typically is rapid; individuals are ... Radical retropubic prostatectomy can be performed under general, spinal, or epidural anesthesia and requires blood transfusion ...
Cholesterol, fat, calcium, and other components contribute to the formation of plaque in the blood. Plaque is detrimental to ... The HDL capability of absorption of cholesterol and transport to the liver, aids in the removal of cholesterol in the body. On ... The filtration system of the liver aids in the removal of cholesterol from the body. Therefore, the cholesterol level in the ... This hydrolysis allows for the acceleration or continuation of cholesterol removal from the body to avoid a buildup. Following ...
... removal from the blood). In the healthy individual, the rates of appearance and disposal are essentially equal during exercise ... Although gluconeogenesis is an important component of hepatic glucose output, it alone can not sustain exercise. For this ... aids used in endurance sports to increase the volume percentage of red blood cells (hematocrit), such as through blood doping ... Plasma glucose is said to be maintained when there is an equal rate of glucose appearance (entry into the blood) and glucose ...
In the blood stream, nascent VLDL particles bump with HDL particles; as a result, HDL particles donate apolipoprotein C-II and ... Gram-positive bacteria has a similar component named Lipoteichoic acid, or LTA. HDL has the ability to bind LPS and LTA, ... If oxidised, the LDL can become trapped in the proteoglycans, preventing its removal by HDL cholesterol efflux. Normal ... In the blood stream, nascent chylomicron particles interact with HDL particles, resulting in HDL donation of apolipoprotein C- ...
Goodrich, RP, et al, "Defining 'Adequate' Pathogen Reduction Performance for Transfused Blood Components." Accepted for ... This overarching process, which has come to be known simply as virus removal, is one in which all of the viruses in a given ... Turner ML (2018). "Safety of blood, blood derivatives, and plasma-derived products". Handbook of Clinical Neurology. 153: 463- ... "Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders". Blood ...
ACE is a central component of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of ... peptidyl dipeptidase peptidyl dipeptidase-4 PDH peptidyl dipeptide hydrolase DCP CD143 ACE hydrolyzes peptides by the removal ... Therefore, ACE indirectly increases blood pressure by causing blood vessels to constrict. ACE inhibitors are widely used as ... Some studies suggest that ACE inhibitors that are able to pass the blood-brain-barrier (BBB) could enhance the activity of ...
As a major component of the high-density lipoprotein complex (protective "fat removal" particles), apo A1 helps to clear fats, ... including cholesterol, from white blood cells within artery walls, making the WBCs less likely to become fat overloaded, ... As the major component of HDL particles, it has a specific role in lipid metabolism. The text in a 2014 report suggested that ... The protein, as a component of HDL particles, enables efflux of fat molecules by accepting fats from within cells (including ...
Membrane fractionation has the advantage of minimal protein loss yet high removal of pathological plasma components. This ... Blood plasma is the liquid component of blood, which contains dissolved proteins, nutrients, ions, and other soluble components ... In whole blood, red blood cells, white blood cells, and platelets are suspended within the plasma. The goal of plasma ... There are several components that make up blood plasma, one of which is the protein albumin. Albumin is a highly water-soluble ...
During blood feeding by Ixodid ticks, the liquid portion of the meal is first concentrated by removal of water and excess ions ... what particular components of the tick body cause these reactions is unknown, but it could be a water-soluble component that is ... Tick removal[edit]. Tick removal. Compressing the body of the tick could cause more noxious substance (allergens, salivary ... Debate around the best method of tick removal is based around two main concerns. The first is that the method of removal could ...
Abel JJ, Rowntree LG, Turner BB (1913). "On the removal of diffusible substances from the circulating blood by means of ... An alternative method for extracorporeal separation of blood components such as plasma or cells is apheresis. Hemodialysis can ... The blood is then pumped through the dialyzer, and then the processed blood is pumped back into the patient's bloodstream ... There is some evidence of a reduction in the incidence of heart and blood problems and high blood pressure events when using ...
Goodrich, RP, et al, "Defining 'Adequate' Pathogen Reduction Performance for Transfused Blood Components." Accepted for ... Virus removal[edit]. This overarching process, which has come to be known simply as virus removal, is one in which all of the ... In many cases, researchers may be trying to extract the viruses from the blood for study, not specifically for blood ... "New York Blood Center". Retrieved 2010-11-23.. *^ Ruane PH, et al., "Photochemical Inactivation of Selected ...
... and return or exchange of blood plasma or components thereof from and to the blood circulation. It is thus an extracorporeal ... Other uses are the removal of blood proteins where these are overly abundant and cause hyperviscosity syndrome. Acute ... In such a plasma donation procedure, blood is removed from the body, blood cells and plasma are separated, and the blood cells ... Citrate binds to calcium in the blood, calcium being essential for blood to clot. Citrate is very effective in preventing blood ...
... the removal and return of (components of) blood plasma to blood circulation Plex, a magic robot character in the children's ...
Blood taken from a healthy donor can be separated into its component parts during blood donation, where the needed component is ... Leukocytapheresis - removal of malignant white blood cells in people with leukemia and very high white blood cell counts ... apheresis donors can donate blood more often than those donating whole blood. There are large categories of component ... Plasma exchange - removal of the liquid portion of blood to remove harmful substances. The plasma is replaced with a ...
Carbon dioxide is more readily dissolved in deoxygenated blood, facilitating its removal from the body after the oxygen has ... is formed during physiological respiration when oxygen binds to the heme component of the protein hemoglobin in red blood cells ... "Blood Tests". National Heart, Lung, and Blood Institute (NHLBI). Retrieved 2019-04-27.. ... Because the reaction is slow, the Hb A1c proportion represents glucose level in blood averaged over the half-life of red blood ...
Removal of any one piece destroys the function of the mousetrap. Intelligent design advocates assert that natural selection ... They argue that something that is at first merely advantageous can later become necessary as other components change. ... Behe argued that irreducibly complex biological mechanisms include the bacterial flagellum of E. coli, the blood clotting ... The statement formed a key component of Discovery Institute campaigns to present intelligent design as scientifically valid by ...
... "the fate of the Jews as a sort of blood bond to tie the civil and military leadership to the Nazi cause".[127] ... Hitler's earlier ideas about forcible removal of Jews from the German-controlled territories in order to achieve Lebensraum ... Hilberg divides this bureaucracy into four components or hierarchies: the Nazi Party, the civil service, industry, and the ...
On December 10, 2003, the American Broadcasting Company (ABC) announced the removal of its correspondents from the campaigns of ... but in light of Cheney's visit to his doctor for an inspection of a blood clot, Kucinich decided to postpone the scheduled ... he reluctantly agreed to vote with his colleagues for the Healthcare Bill without a public option component.[18] ...
The components of the medical interview[10] and encounter are: *Chief complaint (CC): the reason for the current medical visit ... After examination for signs and interviewing for symptoms, the doctor may order medical tests (e.g. blood tests), take a biopsy ... although even after removal, significant costs and barriers remain.[19] ... "Chairman's Reflections: Traditional Medicine Among Gulf Arabs, Part II: Blood-letting". Heart Views. 5 (2): 74-85 [80]. 2004. ...
Sides, Blood and Thunder, p. 181. *^ William E. Connelley. A Standard History of Kansas and Kansans, Vol. I. Chicago: Lewis ... "Removal History of the Delaware Tribe". Delaware Tribe of Indians. Retrieved 28 December 2017.. ... was a favorite component of headdresses and breast ornaments for males.[32] The Lenape also adorned themselves with various ... Sides, Hampton, Blood and Thunder: An Epic of the American West, Doubleday (2006), pp. 77-80, 94, 101, hardcover, 462 pages, ...
... and possibly testing for specific antibodies in the blood.[3][11] Blood tests are often negative in the early stages of the ... "Tick Removal". 23 June 2014. Archived from the original on 10 March 2015. Retrieved 2 March 2015.. ... inactivating key immune components such as complement, and hiding in the extracellular matrix, which may interfere with the ... "Tick removal and testing". Lyme Disease. Centers for Disease Control and Prevention. 22 April 2019. Archived from the original ...
Since this activated carbon has no effect on blood clotting factors, heparin or most other anticoagulants [11] this allows a ... Granulated carbons are used for water treatment, deodorization and separation of components of flow system and is also used in ... Some carbons are evaluated based on the dechlorination half-life length, which measures the chlorine-removal efficiency of ... Hemoperfusion is a treatment technique in which large volumes of the patient's blood are passed over an adsorbent substance in ...
Other health conditions such as diabetes, abnormal blood clotting, ostomies, and obesity do not usually present a problem to ... She started with the removal of her original sex organs, the operation supervised by Dr. Magnus Hirschfeld. Lili went on to ... and breast augmentation are also aesthetic components of their surgical treatment. ... For trans men, these may include mastectomy (removal of the breasts) and chest reconstruction (the shaping of a male-contoured ...
However, the surgical removal of large pleural deposits with infusion of hyperthermic chemotherapy may offer significant ... Low grade sarcomas: Sarcoma is a cancer of the bone, cartilage, fat, muscle, blood vessels, or other connective or supportive ... the main component of mucus). ... could occur if the chemotherapy was given through the blood ...
Oct-1-en-3-one, the ketone analog that gives blood on skin its typical metallic, mushroom-like smell[10] ... The name 'mushroom alcohol' is used because octenol is the main flavour component of mushrooms.[7] ... Grapevine bunch rots: impacts on wine composition, quality, and potential procedures for the removal of wine faults. Steel CC, ...
Erectile) prosthesis explantation (removal of the prosthesis without replacement). There is also a possibility of fat embolism ... The blood supplies from the graft and the vein leading to the femoral artery are joined. ... Once the corporotomies are closed and all of the tubing and components of the prosthesis covered with a layer of Buck's fascia ... A later improvement involved the inclusion of a blood supply pedicle which was left in place to prevent tissue death before it ...
As in central apnea, pauses are followed by a relative decrease in blood oxygen and an increase in the blood carbon dioxide. ... Removal or reduction of parts of the soft palate and some or all of the uvula, such as uvulopalatopharyngoplasty (UPPP) or ... OSA also appears to have a genetic component; those with a family history of it are more likely to develop it themselves. ... high blood pressure,[57][58] stroke,[59] diabetes, clinical depression,[60] weight gain and obesity.[citation needed] ...
Cellular component. • cytoplasm. • perinuclear region of cytoplasm. • mitochondrion. • nuclear speck. • cytoplasmic vesicle. • ... "Blood chemicals link' to eczema". BBC News. 26 August 2007.. *^ Shu XQ, Mendell LM (July 1999). "Neurotrophins and hyperalgesia ... neurons they can influence dendritic spine formation and retraction as well as AMPA receptor insertion and removal.[59] At ... is strongly stimulated by calcium and is primarily under the control of a Cre regulatory component, suggesting a putative role ...
Removal in other cases is typically done with a cutting device which threads over the lead and is moved down the lead to remove ... Swelling, bruising or bleeding at the generator site, especially if the patient is taking blood thinners.[24] ... a pacing system that avoids these components offers theoretical advantages. Leadless pacemakers can be implanted into the heart ... In some cases such as a device that has been inserted for a short amount of time, removal may involve simple traction to pull ...
With so much blood going to the external surface of the body, less goes to the active muscles, the brain, and other internal ... The addition of water molecules, or any other molecules, to a gas, without removal of an equal number of other molecules, will ... Therefore, when applying more pressure to a gas saturated with water, all components will initially decrease in volume ... Also, if the atmosphere is as warm as or warmer than the skin during times of high humidity, blood brought to the body surface ...
doi:10.1182/blood-2012-04-418640. PMID 22653976.. *^ Lambrou GI, Papadimitriou L, Chrousos GP, Vlahopoulos SA (April 2012). " ... Individual components of the 19S particle have their own regulatory roles. Gankyrin, a recently identified oncoprotein, is one ... Pitzer F, Dantes A, Fuchs T, Baumeister W, Amsterdam A (September 1996). "Removal of proteasomes from the nucleus and their ... In particular, exit from mitosis requires the proteasome-dependent dissociation of the regulatory component cyclin B from the ...
Identification and removal of foreign substances present in organs, tissues, blood and lymph, by specialized white blood cells ... On one hand, γδ T cells may be considered a component of adaptive immunity in that they rearrange TCR genes to produce ... A scanning electron microscope image of normal circulating human blood. One can see red blood cells, several knobby white blood ... All white blood cells (WBCs) are known as leukocytes. Most leukocytes differ from other cells of the body in that they are not ...
Read, Peter (1981). The Stolen Generations: The Removal of Aboriginal children in New South Wales 1883 to 1969 (PDF). ... Over time Australia has used various means to determine membership of ethnic groups such as lineage, blood quantum, birth and ... there is also a Eurasian component that could indicate South Asian admixture or more recent European influence.[44][45] ... However, in 1889 Parliament recognised Fanny Cochrane Smith (d:1905) as the last surviving full-blooded Tasmanian Aborigine.[g] ...
Molds are ubiquitous in the biosphere, and mold spores are a common component of household and workplace dust. The vast ... "National Heart, Lung, and Blood Institute. October 1, 2010. Retrieved January 15, 2014.. ... Removal of affected materials after the source of moisture has been reduced and/or eliminated may be necessary.[42] Thus, the ... metabolites and other components.[6] The most common health problem is an allergic reaction. Other problems are respiratory and ...
A gallstone is a stone formed within the gallbladder out of bile components.[2] The term cholelithiasis may refer to the ... Gallstone complications may be detected on blood tests.[2]. A positive Murphy's sign is a common finding on physical ... Cholecystectomy (gallbladder removal) has a 99% chance of eliminating the recurrence of cholelithiasis. The lack of a ... The bile components that form gallstones include cholesterol, bile salts, and bilirubin.[2] Gallstones formed mainly from ...
Blood transfusion, and Blood substitute. A blood product (or blood-based product) is any component of blood which is collected ... Removal of a port is usually a simple outpatient procedure; however, installation is more complex and a good implant is fairly ... Early blood transfusions consisted of whole blood, but modern medical practice commonly uses only components of the blood, such ... Blood substitutes (also called 'artificial blood' or 'blood surrogates') are artificial substances aiming to provide an ...
Stevens, M. Allen (1986). "Inheritance of Tomato Fruit Quality Components". Plant Breeding Reviews. 4. Westport, CT: Avi ... who suggested that a new type of eggplant had been brought to Italy that was blood red or golden color when mature and could be ... The 2008 United States salmonellosis outbreak caused the temporary removal of tomatoes from stores and restaurants across the ...
Blood. 100 (9): 3063-3067. doi:10.1182/blood-2002-03-0996. Schey, S.A. (15 August 2004). "Phase I Study of an Immunomodulatory ... This is believed to be a main component of the mechanism in vivo by which thalidomide inhibits multiple myeloma. Additionally, ... with an added amino group at position 4 of the phthaloyl ring and removal of a carbonyl group from the phthaloyl ring. ... This explains the effect of thalidomide when given to ENL patients, as they commonly have high levels of TNF-α in their blood ...
Laser hair removal and electrolysis are also available, though these are provided (in the US) by licensed professionals in ... The entire follicle and root are fed by a supply of arteries, and blood carries nutrients to the follicle/root. Any time an ... Dairy products are good sources of calcium, a key component for hair growth. A balanced diet is extremely necessary for a ... In many gynecological exams a blood screen for thyroid is now a common protocol. Thyroid often shows up first in the behavior ...
... to feed on an uninfected host and regurgitate some of the infected blood from the first blood meal into the tissue of the ... The sustainable removal of the tsetse fly is in many cases the most cost-effective way of dealing with the T&T problem ... SIT is among the most environmentally friendly control tactics available, and is usually applied as the final component of an ... The tsetse are obligate parasites that live by feeding on the blood of vertebrate animals. Tsetse have been extensively studied ...
Ingenious experiments that first identified a stem cell-the blood-forming stem cell-which set the stage for all current ... The discovery of dendritic cells-the preeminent component of the immune system that initiates and regulates the body's response ... For revolutionizing the surgical removal of cataracts, turning a 10-day hospital stay into an outpatient procedure, and ... Discovery of the virus that causes hepatitis C and the development of screening methods that reduced the risk of blood ...
Cellular component. • integral component of membrane. • membrane. • platelet alpha granule membrane. • platelet dense granule ... doi:10.1182/blood-2004-07-2698. PMC 1895372 . PMID 16332977.. *^ Wein M, Sterbinsky SA, Bickel CA, Schleimer RP, Bochner BS ( ... In addition to GAGs, mucin is of interest in P-selectin mediated tumor metastasis.[25] Selective removal of mucin results in ... integral component of plasma membrane. • plasma membrane. Biological process. • leukocyte cell-cell adhesion. • heterophilic ...
Anemia from bleeding may require iron supplementation or blood transfusion. As WAS is primarily a disorder of the blood-forming ... For severely low platelet counts, patients may require platelet transfusions or removal of the spleen. For patients with ... "Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease". Nature ... The diagnosis is made on the basis of clinical parameters, the peripheral blood smear, and low immunoglobulin levels. Typically ...
Detail of the Last Supper from Tilman Riemenschneider's Altar of the Holy Blood, 1501-05, Rothenburg ob der Tauber, Bavaria ... Casting may be used to form hot liquid metals or various materials that cold set after mixing of components (such as epoxies, ... A wide variety of materials may be worked by removal such as carving, assembled by welding or modelling, or molded, or cast. ... Stone sculpture is an ancient activity where pieces of rough natural stone are shaped by the controlled removal of stone. Owing ...
Henna is an orange dye commonly used as a deposit-only hair color whose active component, lawsone, binds to keratin. It is ... a b Hair Dye Linked to Blood Cancer. Retrieved on 2010-12-21. ... Because there is essentially no lifting (i.e., removal) of natural hair color, the final color is less uniform/homogeneous than ... Articles link the development of some forms of cancer (including leukemia, non-Hodgkin's lymphoma, bladder cancer, blood cancer ...
... from a substance such as whole blood or plasma. Advantageously, the ... device and method for the removal of selected factors, such as cytokines or pharmaceuticals, ... The method of claim 1, wherein said blood component is plasma. 40. The method of claim 17, wherein said blood component is ... 1. A method for removing selected factors in a mammalian subjects blood or blood component, comprising contacting the blood or ...
A method for removing or reducing concentration or amount of a metabolic component in blood or plasma of a subject is also ... and the application of an electrical potential across these barriers to selectively remove metabolic components from blood or ... An electrophoresis system for removing or reducing concentration of a metabolic component from blood or plasma of a subject is ... US7066900B2 - Removal of metabolic components from blood - Google Patents. Removal of metabolic components from blood Download ...
"Blood Component Removal" by people in UAMS Profiles by year, and whether "Blood Component Removal" was a major or minor topic ... "Blood Component Removal" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Blood Component Removal" by people in Profiles over the past ten years. ... Blood Component Removal*Blood Component Removal. *Blood Component Removals. *Component Removal, Blood ...
Blood component therapy in clinical practice / edited by Robert W. Beal and James P. Isbister.. by Beal, Robert W , Isbister, ...
We show a nearly complete removal of both albumin and IgA from concentrated RBCs via this one-step-processes in samples ... The preparation of protein free RBC concentrate is important for blood transfusion to patients suffering from immunoglobulin A ... the development of a miniaturized system for removing plasma proteins and other low-molecular-weight compounds from red blood ... Acoustophoretic removal of proteins from blood components.. @article{Tenje2015AcoustophoreticRO, title={Acoustophoretic removal ...
Blood Component Removal Detailed Description:. Protocol Design: This protocol is designed to perform collection of human ... Blood is removed through a needle in the vein of one arm and spun in a machine that separates out the desired component (plasma ... Blood samples may be collected either by ordinary blood drawing (phlebotomy) or by apheresis, a procedure for collecting a ... These components can be safely obtained using apheresis procedures in the Apheresis Clinic of the Clinical Center Department of ...
Good health is absolutely important to a human being and to remain healthy people need to check their blood level parameters. ... DMCA / Removal Request. If you are the original writer of this essay and no longer wish to have your work published on the ... ,title=Calculating Blood Components of ... The chief blood components are Cholesterol, NaCl, Glucose, Urea, Lactate & Alanine.. There are quite a few number ways to ...
... such as blood, containing at least two compounds, the relative mobilities of which in an electric field vary as a function of ... Removal of metabolic components from blood. EP1434645A4 *. Sep 4, 2002. Dec 13, 2006. Gradipore Ltd. Removal of metabolic ... is injected into the blood, upstream from the cell, at the same flow rate (that is, approximately 8 units/hour/cm of blood) by ... the cell can consist of concentric annular components or of superimposed flat components. In the latter case the height of the ...
ABO Blood-Group System* * Adult * Aged * Blood Component Removal / methods* * Blood Group Incompatibility* ...
Three major types of blood products are transfused to patient … ... ABO histo-blood groups, citrate as anticoagulant, fractionation ... Limited number of important discoveries have greatly contributed to the progresses achieved in the blood transfusion; ... Blood Component Removal * Blood Platelets / metabolism * Blood Proteins / chemistry * Blood Transfusion / methods* ... Three major types of blood products are transfused to patients: red cell concentrates, platelet concentrates and fresh frozen ...
... a residual blood fluid, and an interface between the first separated blood component and the residual blood fluid. The method ... During the separating step, the method accumulates a second separated blood component in the interface without withdrawal from ... withdraws the first separated blood component out of the rotating chamber through a first outlet port, and also withdraws the ... the rotating chamber into flow communication with a selected outlet port and withdraws the second separated blood component ...
The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some ... Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in ... at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a ... The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. ...
Apheresis and Specimen Collection Procedures to Obtain Plasma Peripheral Blood Mononuclear Cells (PBMCs) and Other Specimens ... Blood is removed through a needle in the vein of one arm and spun in a machine that separates out the desired component (plasma ... Blood samples may be collected either by ordinary blood drawing (phlebotomy) or by apheresis, a procedure for collecting a ... These components can be safely obtained using apheresis procedures in the Apheresis Clinic of the Clinical Center Department of ...
Blood Donor Leukocyte Transfusion Granulocyte Colony-Stimulation Factor Blood Component Removal Drug: Filgrastim (G-CSF) Drug: ... Granulocyte components are not recognized as a licensed blood component by the Food and Drug Administration (FDA), and neither ... Improving White Blood Cell Collection From Healthy Donors. The safety and scientific validity of this study is the ... Initial blood tests will be done to check for eligibility.. *Participants will donate granulocytes by apheresis a maximum of 12 ...
... processing the blood to harvest components such as platelets, and returning processed blood to the donor through the single ... Processing is performed by a centrifuge which separates blood components into stratified layers with a buffy coat containing ... A storage bag receives processed blood during the draw cycle and blood is squeezed from the bag during the return cycle, a ... platelets and white blood cells stably interfacing a red blood cell layer. Blood is withdrawn during a draw cycle and returned ...
Removal of selected factors from whole blood or its components. 1998-03-24. Okarma et al.. ... will drive cellular blood components against the filter membrane. Contact with cellular blood components can also clog the ... includes a blood handling unit 36. mounted on the chassis panel 26. . The blood handling unit 36. includes a peristaltic blood ... i) Blood Supply and Return Paths. The arterial blood supply path 62. and venous blood return path 64. includes lengths of ...
Removal of selected factors from whole blood or its components. US5554340 *. 23 Oct 1995. 10 Sep 1996. Sapidyne, Inc.. Assay ... Removal of selected factors from whole blood or its components. US6120734 *. 24 Jun 1994. 19 Sep 2000. Sapidyne, Inc.. Assay ... Removal of selected factors from whole blood or its components; and prevention and treatment of septic shock syndrome. ... The barrier also functions as an immobilized component of the substrate to which the antibodies may be attached. Since assays ...
... from whole blood. More specifically, it relates to a process for making a microporous plasmapheresis membrane having an ... The present invention relates to the efficient removal of low density lipoprotein cholesterol complex (LDL-C) ... The plasma is treated in LDL-C removal device 28 exiting via plasma exit port 30. The remaining blood components (high ... The blood passes from blood removal apparatus 14 into whole blood tubing 16 and is pumped via optional blood pump 18 into LDL-C ...
Blood Component Removal (Apheresis) 12/01/2009 - "An open-label prospective randomized multicenter study shows very rapid ...
Blood Component Removal (Apheresis) 2. Transplants (Transplant) 3. Plasmapheresis 4. Spinal Fusion (Spondylosyndesis) ... Factor I; Blood Coagulation Factor I; gamma-Fibrinogen; Factor I, Coagulation; I, Coagulation Factor; gamma Fibrinogen; ... 07/01/2003 - "ECC blood flow was at least 75 ml/min. Platelet and fibrinogen measurements were made hourly, and circuit ... leading to a significant reduction in allogeneic blood products transfusions. ". 05/01/2005 - "On multiple logistic regression ...
The blood circulates through a machine that separates it into its components. The required component (plasma or cells) is ... Skin biopsy Removal of a small skin sample for microscopic analysis. An area of skin is numbed with an anesthetic and a small ... Apheresis Collection of plasma (fluid portion of blood) or blood cells for analysis. Whole blood is collected through a needle ... Genetic studies Collection of a blood sample for gene testing.. Patients will be followed at least once a year with a brief ...
Fecal Impaction Removal. *Fecal Incontinence. *Fecal Occult Blood Test. *Feedback Systems. *Fertility Treatments ...
The article talks about the various ways in which skin tag removal can be done. It also lists the various precautions that ... Castor oil is another vital component, that helps in the removal of skin tags. A paste of proper consistency is formed, by ... There is blood loss caused by this method. However, the wound is cleaned and an antibacterial ointment is applied on it. ... The removal of skin tags is not covered by most of the insurance companies. The reason behind this being that the removal of ...
Recruitment of white blood cells. Removal of injurious agent. Regulation (control) of response. Resolution/repair. ... Involves recruitment of cellular component of inflammatory response, (-> phagocytosis). Release of chemical mediators,. ... Local increase in blood flow (local hyperaemia). Engorgement of capillary beds. Erythema (redness). 3. Increased intravascular ... BLOOD LEUKOCYTES. POLYMORPHONUCLEAR LEUKOCYTES- Neutrophils, eosinophils, basophils. MONONUCLEAR LEUKOCYTES- Monocytes ( ...
... an activity associated with removal of various intracellular components. They also observed a decrease in LC3B, an essential ... Article: Blood-Spinal Cord Barrier Alterations in Subacute and Chronic Stages of a Rat Model of Focal Cerebral Ischemi, ... University of South Florida (USF Health). "USF researchers find stroke damages blood-spinal cord barrier." Medical News Today. ... University of South Florida (USF Health). (2016, June 14). "USF researchers find stroke damages blood-spinal cord barrier." ...
Components in these kits are used to assist in the treatment and removal of sutures. ... Wall Mount Blood Pressure Unit, Arm, Adult, 11" to 16-3/8" Cuff Size, Nylon, Black Item # 30XG531 ...
... were used for analysis of blood smears coming from healthy male donors. Different blood plasma removal, matrix deposition, and ... Red and white blood cells chemical composition was analyzed using the differential m/z expression. Five seconds of exposure to ... This study sets the foundations for application of blood smear MALDI TOF MSI in clinical diagnostics and research. ... of blood smear. Integrated light microscope and MALDI IT-TOF mass spectrometer, together with a matrix sublimation device, ...
Blood Component Removal LDL Lipoproteins 2013 50 Citations Loss of plasma proprotein convertase subtilisin/kexin 9 (PCSK9) ...
Separation of blood into component parts and removal of a select portion from the blood. Plasmapharesis - plasma, ... Collection and later reinfusion of a patients own blood or blood components ... Removal of plasma from withdrawn blood by centrifuge. Collected cells are retransfused back into the donor. Fresh-frozen plasma ... Antigen on red blood cells of Rh-positive individuals. The factor was first identified in the blood of a rhesus monkey ...
Apo E is required for the normal removal of triglyceride-rich particles from the blood via hepatic apo E receptors. Apo C-II ... The triglyceride (TG) component of chylomicrons is removed by lipoprotein lipase located on the vascular endothelium of muscle ... The triglyceride component of chylomicrons is removed by lipoprotein lipase. The resulting chylomicron remnants are cleared by ... Laboratory investigations to exclude secondary disorders of lipid metabolism should include measurement of fasting blood ...
  • 4. A method according to claim 2 wherein, in the accumulating step, the second separation blood component comprises platelets. (
  • These components include red blood cells, platelets and plasma. (
  • The collection of platelets or plasma from volunteer donors, as opposed to the collection of whole blood, has not been nearly as successful. (
  • The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. (
  • A single needle system for withdrawing donated blood, processing the blood to harvest components such as platelets, and returning processed blood to the donor through the single needle. (
  • Processing is performed by a centrifuge which separates blood components into stratified layers with a buffy coat containing platelets and white blood cells stably interfacing a red blood cell layer. (
  • Thrombotic thrombocytopenic purpura (TTP) is a rare blood condition characterised by the formation of small clots (thrombi) within the circulation, which results in the consumption of platelets and thus a low platelet count (thrombocytopenia). (
  • Each multimer is able to bind to platelets or damaged endothelium (lining of blood vessels) at the site of an injury. (
  • As the condition progresses clots (thrombi) form within blood vessels and platelets (clotting cells) are consumed. (
  • red and white blood cells as well as platelets. (
  • Preparation of Components Centrifuge - light spin, platelets suspended Remove platelet rich plasma (PRP) Centrifuge PRP heavy spin Remove platelet poor plasma Freeze plasma solid within 8 hours Thaw plasma at 1-4C - precipitate forms Centrifuge, express plasma leaving cryoprecipitate. (
  • Plasma is the single largest component of blood and is the clear liquid that remains after the removal of red and white blood cells and platelets. (
  • any procedure in which blood is withdrawn from a donor, a portion (such as plasma, leukocytes, or platelets) is separated and retained, and the remainder is retransfused into the donor. (
  • Infusion of a patient's own blood from which certain cellular or fluid elements (for example, plasma, leukocytes, or platelets) have been removed. (
  • aph·e·re·sis/ ( af″ĕ-re´sis ) withdrawal of blood from a donor, with a portion (plasma, leukocytes, platelets, etc.) being separated and retained and the remainder retransfused into the donor. (
  • 2. apheresis (ăf′ə-rē′sĭs) Medicine A procedure in which blood is drawn from a donor and separated into its components, some of which are retained, such as plasma or platelets, and the remainder returned by transfusion to the donor. (
  • Red blood cells , platelets and plasma proteins cannot pass through the walls of the capillaries . (
  • All of the blood cells (red cells, white cells, platelets) are derived from stem cells in the bone marrow. (
  • The accumulation of ineffective lymphocytes can interfere with the production of other blood cells, such as red cells and platelets, and the immune system. (
  • Lifeblood continuously monitors bacterial contamination rates in Australia and these numbers are in line with international published data of approximately 1 in 1000 - 3000 units of platelets (single donor apheresis and whole blood pooled platelets). (
  • Von Willebrand disease is due to the lack of von Willebrand factor , a plasma protein that binds to factor VIII and promotes the interaction of platelets with the blood vessel . (
  • Disseminated intravascular coagulation is an acquired disorder in which platelets and blood-clotting components are consumed until a severe deficiency exists, resulting in a bleeding disorder. (
  • Platelets tend to adhere to such lesions and eventually form masses that, when reinforced by fibrin, may completely obstruct the blood flow. (
  • Other predisposing causes of thrombosis are an increase in platelet numbers in the blood and the formation of functionally abnormal platelets in diseases of the bone marrow . (
  • In addition, a subset of these patients will undergo several tests to understand the pathogenic changes affecting their blood vessels. (
  • Release of chemical mediators, Exudation of fluids and proteins from blood vessels. (
  • Fifth, The CBV and CBF in blood vessels are much higher than those in the brain parenchyma. (
  • Circulating ULvWF leads to the inappropriate formation of platelet clumps (thrombi) particularly within blood vessels supplying the brain and kidneys. (
  • Soft tissue includes connective tissue, muscle, fat, nerves and blood vessels that perform important functions throughout the body. (
  • Benign soft tissue tumors are more common, including lipomas (fatty tissue), hemangiomas (blood vessels) and leiomyomas (smooth muscles). (
  • For extremity sarcomas, our fellowship trained surgeons focus on limb salvage with preservation of critical structures including nerves and blood vessels. (
  • bradykinin , for example, causes contraction of most smooth muscles and has a very potent action in dilating certain blood vessels. (
  • The global component may be more pronounced in fNIRS than in functional magnetic resonance imaging (fMRI) acquisitions because the near-infrared lights pass through superficial layers of blood vessels in skin and yield significant signal changes primarily due to systemic components. (
  • Examination of the fundus (inner surface of eye) can show no results or it can show narrowing of the blood vessels, abnormal colouration of the optic disc, and retinal atrophy. (
  • Tissue fluid can pass into the surrounding lymph vessels, and eventually ends up rejoining the blood. (
  • The wounded area attempts to restore its normal state by constricting blood vessels to control bleeding. (
  • New blood vessels form. (
  • Thrombosis , the formation of a blood clot (thrombus) that tends to plug functionally normal blood vessels, is one of the major causes of death in Western societies. (
  • This obstruction may have disastrous consequences in arteries such as the coronary or cerebral blood vessels or a major artery of a limb or organ. (
  • The tea contains polyphenols, which fight free radicals, preventing aging and blood clots formation improving skin and vessels condition. (
  • The 20103 code identifies surgical exploration and enlargement of the defect, dissection, debridement, any foreign body removal, and cauterization of smaller blood vessels. (
  • If any extensive repairs are performed on structures, organs, muscles, major blood vessels, or subcutaneous tissue of the extremity, they should be reported with the appropriate repair code-in this case, the 35556 code. (
  • Any procedure in which blood is withdrawn from a donor, a portion is separated and retained and the remainder is returned to the donor. (
  • The development of single needle, single use, disposable blood collection sets has provided a safe, relatively inexpensive and donor comfortable medium for use in the blood collection process. (
  • In recent years, processing of whole blood from a donor has come to routinely include separating the blood into therapeutic components. (
  • Blood is withdrawn during a draw cycle and returned to the donor during a return cycle. (
  • A storage bag receives processed blood during the draw cycle and blood is squeezed from the bag during the return cycle, a portion returned to the donor and another portion entering the recirculation path. (
  • Blood cells or whole blood from a closely matched donor are infused into a patient. (
  • Laboratory technician hanging up bags of donor blood that are connected to filters (lower centre) by tubes. (
  • Transplant surgery is the surgical removal of an organ(s), tissue, or blood products from a donor and surgically placing or infusing them into a recipient. (
  • In the cartoon on the left, an IV is inserted in one arm of the donor, then whole blood is then introduced into the chamber or centrifuge and the blood separates into components by gravity along the wall of the chamber. (
  • The remaining components are then returned to the donor through an Iv in the other arm. (
  • a procedure in which blood is temporarily withdrawn, one or more components are selectively removed, and the rest of the blood is reinfused into the donor. (
  • The process is used in treating various disease conditions in the donor and for obtaining blood elements for the treatment of other patients or for research. (
  • The removal of whole blood from a patient or donor followed by separation into its components, some of which is discarded, with the rest being returned to the patient. (
  • Extraction of a specific component from donated blood, with the remainder returned to the donor. (
  • Instead of treating the plasma and blood cells, they are replaced with a healthy donor mixture. (
  • Jeffus S, Wehrli G. Blood banking and transfusion medicine for the apheresis medicine practitioner. (
  • Blood samples may be collected either by ordinary blood drawing (phlebotomy) or by apheresis, a procedure for collecting a larger quantity of blood cells or plasma than would be possible through simple blood drawing. (
  • These components can be safely obtained using apheresis procedures in the Apheresis Clinic of the Clinical Center Department of Transfusion Medicine (DTM). (
  • ABO histo-blood groups, citrate as anticoagulant, fractionation of plasma proteins, plastic bags and apheresis machines. (
  • To improve the amount and quality of granulocytes (white blood cells) collected by apheresis for donation. (
  • White blood cells will be collected through apheresis. (
  • Apheresis Collection of plasma (fluid portion of blood) or blood cells for analysis. (
  • therapeutic apheresis separation of whole blood into its major components and removal of the abnormal, pathogenic component. (
  • Bacterial contamination of blood components: risks, strategies, and regulation: joint ASH and AABB educational session in transfusion medicine. (
  • This invention provides a composition, device and method for the removal of selected factors, such as cytokines or pharmaceuticals, from a substance such as whole blood or plasma. (
  • Pharmaceuticals can be removed from an individual's whole blood or plasma, such as for use in treating drug overdosage. (
  • This work presents the development of a miniaturized system for removing plasma proteins and other low-molecular-weight compounds from red blood cell (RBC) concentrate in a simple one-step-process using integrated ultrasound. (
  • Blood is removed through a needle in the vein of one arm and spun in a machine that separates out the desired component (plasma or white blood cells). (
  • Three major types of blood products are transfused to patients: red cell concentrates, platelet concentrates and fresh frozen plasma. (
  • 3. A method according to claim 2 wherein, in the separating step, the first separated blood component comprises red blood cells and the residual blood fluid comprises plasma. (
  • The required component (plasma or cells) is removed and the rest of the blood is returned to the body through the same needle or through a second needle in the other arm. (
  • Different blood plasma removal, matrix deposition, and instrumental settings were evaluated using the negative and positive ionization modes while agreement between the light microscopy images and the lateral distributions of cellular marker compounds served as the MSI quality indicator. (
  • MONTREAL, Canada and CAMBRIDGE, United Kingdom, June 10 /PRNewswire-FirstCall/ - ProMetic Life Sciences Inc. (TSX:PLI) ("ProMetic") announces that Octapharma AG ("Octapharma"), one of the World's leading plasma fractionators and manufacturer of Octaplas(R) (Solvent/Detergent treated plasma), is sponsoring a Symposium during the 30th International Congress of the International Society of Blood Transfusion ("ISBT") meeting being held in Macao SAR, China. (
  • The Symposium is entitled "Prion safety and Transfusion Plasma" and will have some of the world leading authorities in Transmissible Spongiform Encephalopathy ("TSE") disease research presenting data on the utility of Pathogen Removal and Diagnostics Technologies Inc.'s ("PRDT") prion removal resin technology in this application. (
  • The use of PRDT's proprietary ligand technology, which is licensed exclusively to ProMetic, ensures the removal of any abnormal prion proteins that may be present in donated plasma. (
  • It can result from abnormal plasma components such as paraproteins (seen in Waldenstrom's macroglobulinemia [WM] and multiple myeloma [MM]) or immune complexes (systemic lupus erythematosis). (
  • vWF is a normal component of plasma, the straw-coloured fluid in which blood cells are suspended. (
  • These techniques are used widely in the food and blood plasma industries, as those products can be harmed by the presence of viral particles. (
  • Viral inactivation is used widely in the blood plasma industry. (
  • Especially blood plasma proteins (e.g. serum albumin) are known to interfere with electrospray ionization and result in analyte ion suppression. (
  • Plasmapheresis involves separating blood into two parts - blood cells and plasma. (
  • The blood plasma components, such as the antibodies, are treated outside of the body. (
  • After removal of the disease-associated antibodies, the blood cells and plasma are transfused back into the body. (
  • In vitro experiment on anti-angiogenic molecule docetaxel prodrug in perfluorocarbon (PFC) nanoparticles cites Cleanascite™ for lipid removal from plasma-enzyme-nanoparticle mixture. (
  • It is the main component of the extracellular fluid, which also includes plasma and transcellular fluid. (
  • Plasma, the major component in blood, communicates freely with interstitial fluid through pores and intercellular clefts in capillary endothelium . (
  • The resulting mixture that does pass through is essentially blood plasma without the plasma proteins. (
  • Weimer, T. 1997-09-01 00:00:00 BACKGROUND: The viral safety of human plasma products is based on the careful selection of donors and donations and the removal and inactivation of human pathogenic viruses that could potentially contaminate human plasma. (
  • Intravascular fluid is the plasma component of blood (McCance & Huether, 1998). (
  • Leucocyte filtration is a complicated process that is influenced by factors such as the blood component's prefiltration cellular composition and plasma content, the temperature of the blood component at the time of filtration, the filtration flow rate, the number of units transfused through the filter, and the timing of the filtration step. (
  • Therapeutic plasma exchange (TPE) facilitates the non-selective removal of pathogenic substances from a patient's plasma. (
  • During TPE the plasma is separated from the cellular blood components. (
  • 8. A method in accordance with claim 7 wherein excess quantities of said photoactivated cortisone are removed from the extracorporeal stream by withdrawing blood plasma at said centrifuge and replacing same with fresh photoactivated cortisone-free plasma. (
  • An antibody is a protein produced by lymphocytes (nongranular white blood cells) that binds to an antigen, facilitating its removal by phagocytosis (or engulfing by macrophages) or lysis (cell rupture or decomposition). (
  • Its removal in newborn mice results in a deficiency of one type of white blood cells (lymphocytes) and a consequent likelihood of early death from infection. (
  • Preparations of thymus glands from various species contain a protein component, called thymosin, that promotes the development of lymphocytes. (
  • In CLL, high numbers of abnormal lymphocytes are found in the blood, lymph nodes, spleen, and bone marrow. (
  • Stage III - Increased abnormal lymphocytes with anemia (low red blood cell count), with or without an enlarged spleen, liver, or lymph nodes. (
  • Advantageously, the invention provides for the treatment or prevention of septic shock syndrome or other conditions evidenced by the presence of cytokines in a patient by contacting the patient's whole blood with a composition comprising silica and a surface treatment material, such as heparin, but preferably human serum albumin (HSA). (
  • Peripheral blood smear: rouleaux formation can be seen in patient's paraproteinemia. (
  • One of the fundamental, yet most problematic, components of the hemodialysis prescription is the patient's estimated dry weight (EDW). (
  • Further, the physician must be aware that the patient's posture prior to the blood draw is significant. (
  • Secretion removal from patient's air passages to allow ventilation. (
  • it is released from the breakdown of hemoglobin when red blood cells die. (
  • The red colour of blood reflects the colour of the hemoglobin inside the red blood cells. (
  • [17] In 1851, [18] German physiologist Otto Funke published a series of articles in which he described growing hemoglobin crystals by successively diluting red blood cells with a solvent such as pure water, alcohol or ether, followed by slow evaporation of the solvent from the resulting protein solution. (
  • The role of hemoglobin in the blood was elucidated by French physiologist Claude Bernard . (
  • Based in New Jersey, it's principal products include: AlbuSorb™& AlbuVoid™ for albumin depletion, Cleanascite™ for lipid adsorption and clarification, HemogloBind™ & HemoVoid™ for hemoglobin removal, NuGel™ for functional & chemical proteomics, and ProCipitate™ & ProPrep™ for nucleic acid isolation. (
  • The yellow breakdown product of heme catabolism (heme is the principle component of hemoglobin, present in red blood cells). (
  • Heme is an essential component of iron-containing proteins called hemoproteins, including hemoglobin (the protein that carries oxygen in the blood). (
  • Pulse oximeters that measure oxygenated and deoxygenated hemoglobin in arterial blood. (
  • The test classifies blood into four groups designated A, B, AB, and O. Antibody screening is a test to detect atypical antibodies in the serum that may have been formed as a result of transfusion or pregnancy. (
  • This test insures that no antibodies are detected in the recipient's serum that will react with the donor's red blood cells. (
  • The tests are performed on blood after it has been separated into cells and serum (the yellow liquid left after the blood cells are removed). (
  • When red blood cells having a certain blood type antigen are mixed with serum containing antibodies against that antigen, the antibodies combine with and stick to the antigen. (
  • In 1901, Karl Landsteiner, an Austrian pathologist, randomly combined the serum and red blood cells of his colleagues. (
  • Laboratory evaluation includes a complete blood count (CBC), peripheral blood smear, serum electrolytes and serum viscosity. (
  • Compared with urine samples, blood serum samples show smaller variability under normal physiological conditions so are a better choice for elemental screening, say the researchers. (
  • Publication date: Available online 19 November 2019Source: Protein Expression and PurificationAuthor(s): Chandler B. Est, Regina M. MurphyAbstractRetinol binding protein IV (RBP) functions as the principal carrier of retinol (Vitamin A) in the blood, where RBP circulates bound to another serum protein, transthyretin. (
  • Excessive serum and lipase surrounding taxane prodrug in PFC nanoparticles was optimized using Cleanascite™, a lipid removal reagent. (
  • At 32 5/7 weeks of gestation, the patient complained of epigastric pain, blood pressure was 180/110 mmHg, proteinuria was documented (780 mg protein in a 24-hour urine collection), schistocytes were detected in the peripheral smear, platelet count was 60,000 cells per mm 3 , and serum glutamic oxaloacetic transaminase was 234 U/l. (
  • He originally developed the small molecule drug, called CPHPC, to remove a normal blood protein, called serum amyloid P component (SAP), from amyloid deposits. (
  • The type and screen (T&S) is performed on persons who may need a transfusion of blood products. (
  • Roberson RS, Lockhart E, Shapiro NI, Bandarenko N, McMahon TJ, Massey MJ, White WD, Bennett-Guerrero E. Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers. (
  • White blood cells called granulocytes help the body fight infection. (
  • Researchers want to study the best ways to collect these white blood cells. (
  • Red and white blood cells chemical composition was analyzed using the differential m / z expression. (
  • Red blood cells (RBC) circulate for approximately 4 months through the human vascular system [ 1 ]. (
  • A lack of adequate numbers of oxygen-carrying red blood cells. (
  • The antigens found on the surface of red blood cells are important because they determine a person's blood type. (
  • A person's ABO blood type-A, B, AB, or O-is based on the presence or absence of the A and B antigens on his red blood cells. (
  • By the time a person is six months old, he or she will have developed antibodies against the antigens that his or her red blood cells lack. (
  • Protein [immunoglobulin] made by white blood cells in response to foreign substances [antigens] in the blood - An antibody is specific to an antigen and inactivates it. (
  • This procedure can remove toxic substances or autoantibodies from the blood and can collect blood cells. (
  • Failure of blood cell production due to aplasia (absence of formation) of bone marrow cells. (
  • A common filtration stage for whole blood is the removal of leucocytes (white blood cells). (
  • Using cell culture and mouse models, as well as patient-derived tumor tissues, and tumor cells circulating in the blood (Circulating Tumor Cells/CTCs), the Maheswaran Lab has uncovered novel tumor cell characteristics that promote metastasis in breast cancer patients. (
  • Upon reaching these distal sites, the tumor cells continue to grow and evolve well after removal of the primary tumor resulting in overt metastasis and disease recurrence, the leading causes of cancer-related deaths. (
  • Using cell culture and mouse models and patient derived tissues and circulating tumor cells (CTCs) enriched from the blood of women with breast cancer, we characterize the contribution of oncogenic and tumor microenvironment-derived signals, epithelial to mesenchymal transition and tumor heterogeneity to cancer progression and therapeutic responses. (
  • CTCs represent an extremely rare population of cells in the blood and their isolation presents a tremendous technical challenge. (
  • It causes a rush of white blood cells to the problem area and eradicates blemishes. (
  • They start creating a rush of white blood cells in the area of the tag. (
  • The abundant amount of white blood cells turns the skin area from pink to mild red color. (
  • The phenomena happened because of the concentration of white blood cells in the spot area. (
  • Each year, approximately 13,898,000 units of red cells or whole blood are transfused in the United States alone ( 1 ). (
  • From 1976 through September 1998, 26 fatalities thought to be secondary to contaminated whole blood or red cells were reported to the U.S. Food and Drug Administration (FDA) ( 36 ). (
  • This webinar will provide an introduction to leukapheresis, a process that can yield large quantities of primary cells from peripheral blood. (
  • Once inside the cell, these mildly thiol-reactive probes react with intracellular components to produce cells that are both fluorescent and viable for at least 24 hours after loading. (
  • They also cause white blood cells to recirculate away from the area of damage (the retina). (
  • This minimizes damage caused by the antibodies produced by the white blood cells. (
  • Cellular food is transported in blood to provide energy for all the cells' needs. (
  • Do the cells of the body tell the blood how it should work? (
  • No. The cells and the blood work together to provide optimum conditions for correct functioning of all the cells-with their different requirements-in all the tissues and organs of the whole body, including the cells of the blood itself. (
  • As insulin is distributed in the bloodstream, it reduces the blood sugar to normal levels again by increasing the amount of sugar that all cells take in. (
  • There are about fifteen organs classed as hormone-producing (endocrine) glands, 1 and their products, carried by the blood, affect either every cell in general or specifically target certain cells. (
  • abbreviated Hb or Hgb , is the iron -containing oxygen -transport metalloprotein in the red blood cells (erythrocytes) of almost all vertebrates [4] (the exception being the fish family Channichthyidae [5] ) as well as the tissues of some invertebrates . (
  • In mammals , the protein makes up about 96% of the red blood cells' dry content (by weight), and around 35% of the total content (including water). (
  • Haemoglobin is also found outside red blood cells and their progenitor lines. (
  • During human pregnancy, a subset of placental cytotrophoblasts (CTBs) differentiates into cells that aggressively invade the uterus and its vasculature, anchoring the progeny and rerouting maternal blood to the placenta. (
  • On average, a person has about 11 litres (2.4 imperial gallons) of interstitial fluid providing the cells of the body with nutrients and a means of waste removal. (
  • The composition of tissue fluid depends upon the exchanges between the cells in the tissue and the blood . (
  • This provides a means of delivering materials to the cells, intercellular communication, as well as removal of metabolic waste. (
  • With kidney cancers, surgical biopsy and removal of the bulk of the tumor is often a required treatment anyway, so isolating the stem cells directly from tumor biopsies may be the most practical approach for culturing kidney organoids and testing potential therapies for the patient. (
  • The blood treatment method involves removing white cells from the blood through leukoreduction, and then removing prions from the red-cell concentrate using a technique commonly employed for purifying proteins for drug research. (
  • They took 500 mL of scrapie-infected hamster whole blood and purged it of white cells using leukoreduction. (
  • The initial wound touches off a series of separate - yet interdependent - responses to the injury, including inflammation , epithelialization (growth of new skin), angiogenesis (blood vessel regeneration), and the accumulation of cells necessary to heal the tissue. (
  • White blood cells clean the wound of debris and bacteria . (
  • Leucodepletion is a technical term for the removal of leucocytes (white blood cells) from blood components using special filters. (
  • Early removal of leucocytes (within 24 hours) may reduce the likelihood of significant bacterial contamination of red cells, particularly relating to Yersinia enterocolitica and coagulase-negative Staphylococcus. (
  • How many white blood cells are removed during leucodepletion and how is this monitored? (
  • A medical test involving the removal of cells or a small piece of tissue for examination. (
  • A hormone that induces cells to take up glucose from the blood. (
  • The invention pertains to the field of blood component separation and collection. (
  • Various techniques and apparatus have been developed to facilitate the collection of whole blood and the subsequent separation of therapeutic components therefrom. (
  • The processing of blood components may involve centrifugal separation and/or filtering of the blood components. (
  • 2. The system of claim 1 , wherein the chamber comprises a separation chamber, wherein blood components are centrifugally separated in the interior of the container, and wherein the system further comprises a centrifuge rotor configured to be rotated about an axis of rotation, the rotor comprising a portion configured to receive the chamber. (
  • Withdrawal and separation of blood elements into component parts and removal of a select portion from the blood. (
  • We describe a principal component spatial filter algorithm for separation of the global and local effects. (
  • Automated units for blood component collection, separation, and reinfusion. (
  • Preparation of Components Collect unit within 15 minutes to prevent activation of coagulation system Draw into closed system - primary bag with satellite bags with hermetic seal between. (
  • Treatment involves the removal of the inciting cause of the activation of the blood coagulation system. (
  • Blood oxygenation level dependent (BOLD) signals in functional magnetic resonance imaging (fMRI) are often small compared to the level of noise in the data. (
  • Surgical instruments should be presoaked or rinsed to prevent drying of blood and to soften or remove blood from the instruments. (
  • Following the major outbreak of BSE in the United Kingdom in the mid 1980's and the first reported cases of the human disease equivalent, vCJD, in 1996 a number of measures were taken to reduce the risk of secondary transmission of vCJD by blood or surgical instruments. (
  • In this study, an endoscopic surgical approach directed toward the removal of intraventricular hematoma was evaluated for its safety and efficacy. (
  • This occurs most frequently in the leg veins and may be due to slowing of the blood flow during a prolonged surgical procedure or confinement to bed. (
  • In some cases, if pituitary surgery is not successful, surgical removal of the adrenal glands (bilateral adrenalectomy) may take the place of drug therapy. (
  • Surgical removal of the adrenal glands is a final measure for halting excess cortisol production This is used only when all other measures fail in individuals with pituitary tumors. (
  • HVS can also be secondary to increased cellular components due to leukemia or myeloproliferative disorders. (
  • Treatment for HVS secondary to excess cellular components should be treated in an analogous manner, with removal of the specific blood component. (
  • Normal brain parenchyma was automatically segmented with the time-to-peak criteria after cerebrospinal fluid removal and preliminary vessel voxel removal. (
  • We confirmed the necessity of dual thresholds including CBF and CBV for proper removal of vessel voxels. (
  • The automatic scaling and vessel removal techniques provide an alternative method for obtaining improved quantitative assessment of CBV and CBF in patients with thromboembolic cerebral arterial disease. (
  • What factors determine the flow rate of blood through a vessel? (
  • L-arginine helps maintain the body's fluid balance (urea, creatinine), and aids in wound healing, hair growth, sperm production (spermatogenesis), blood vessel relaxation (vasodilation), and fights infection. (
  • While the process of thrombosis is not completely understood, the chief underlying cause is believed to be a lesion ( atherosclerosis ) that destroys the normal endothelial surface of the blood vessel. (
  • Chromatographic methods of removing viruses are great for purifying the protein and are also effective against all types of viruses, but the level of virus removal is dependent on the column composition and the reagents that are used in the process. (
  • Additionally, UV/VIS spectrophotometry was used to determine the protein content of a whole blood sample and IL-DLLME, SPE and PP extracts of the same sample. (
  • A 24-year-old nulliparous woman developed mildly elevated blood pressure (140-150/90-100 mmHg) without proteinuria (20 mg protein in a 24-hour urine collection) at 30 6/7 weeks of gestation. (
  • A method separates blood by centrifugation in a rotating chamber into a first separated blood component, a residual blood fluid, and an interface between the first separated blood component and the residual blood fluid. (
  • The method withdraws the first separated blood component out of the rotating chamber through a first outlet port, and also withdraws the residual blood fluid out of the rotating chamber through a second outlet port. (
  • The first and second panels are oriented in a fluid processing cartridge for mounting as an integrated unit on a fluid processing machine and for removal as an integrated unit from the fluid processing machine. (
  • This difference is created by the direction of the flow of blood and the imbalance in solutes created by the net movement of water favoring the tissue fluid. (
  • Sometimes the removal of tissue fluid does not function correctly, and there is a build-up. (
  • Not all of the contents of the blood pass into the tissue, which means that tissue fluid and blood are not the same. (
  • Tissue fluid also contains some types of white blood cell , which help combat infection. (
  • Avoid Lugol solution and saturated solution of potassium iodide (SSKI, PIMA) with hyperkalemia (high amounts of potassium in the blood), pulmonary edema (fluid in the lungs), bronchitis, or tuberculosis. (
  • According to Gutch, Stoner, and Corea (1999), estimated dry weight is the "ideal postdialysis weight after the removal of all or most excess body fluid" (p. 114). (
  • While fluid moves among compartments related to hydrostatic and osmotic pressures, only fluid contained in the intravascular space is available for removal during ultrafiltration (Ahmad, 1999). (
  • As a basis for determining the intravascular fluid volume available for removal during dialysis, an important step in determining EDW, a quick overview of intravascular refill is warranted. (
  • 10 . The filter assembly of claim 1 wherein said first fluid inlet is adapted to be fluidly connected to a patient to draw a body fluid from said patient and into said first chamber, said second fluid outlet adapted to be fluidly connected to a patient to return at least a component of said body fluid to said patient. (
  • The characteristic symptoms are excessive urine production due to high blood-glucose levels, excessive thirst, increased fluid uptake, unexplained weight loss and lethargy. (
  • Signs and symptoms of leukostasis causing HVS are seen with white blood cell counts greater than 100,000, but can also be seen with a lower WBC. (
  • They cause lymphocytopenia, a condition where white blood cell levels are abnormally low. (
  • Corticosteroids cause white blood cell death, lowering their numbers throughout the body. (
  • CLL is one of a group of diseases that affects a type of white blood cell called a lymphocyte. (
  • Afibrinogenemia, or hypofibrinogenemia, refers to a reduction in the amount of the clotting factor fibrinogen in the blood . (
  • Effect of Skin blood flow (SBF) on functional near-infrared spectroscopy (fNIRS) measurement of cortical activity proves to be an illusive subject matter with divided stances in the neuroscientific literature on its extent. (
  • Blood typing is a laboratory test that identifies blood group antigens (substances that stimulate an immune response) belonging to the ABO blood group system. (
  • In addition to the well-defined hormones, other substances, which are found in blood and in tissues and are of uncertain function, may be concerned in various ways with physiological regulation in vertebrates, although their hormonal status has not yet been established. (
  • Promotes harmful substances removal and internal body environment cleansing. (
  • All the components of the tea drink have therapeutic effect on excretory system, promoting harmful substances removal. (
  • In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. (
  • 3. The system of claim 2 , wherein the system is configured so that the pump pumps blood components from the chamber during rotation of the centrifuge rotor. (
  • 4. The system of claim 2 , further comprising at least one valving member on the centrifuge rotor, the valving member being configured to control flow of at least some of the blood components during rotation of the rotor. (
  • Processing is performed by a centrifuge which separates blood components into stratified layers with a buffy coat containing. (
  • If desired, at least portions of the treated blood may then be separated, as for example by a continuous centrifuge, before returning the remaining diverted blood to the subject. (
  • 7. A method in accordance with claim 3 including the further step of separating at least portions of said lymphocyte population before returning said blood to said subject, by passing said bloodstream through a continuous flow centrifuge. (
  • Beclin-1, explained the researchers, helps induce autophagy, an activity associated with removal of various intracellular components. (
  • The cholesterol obstructs the arteries when it amasses in the body resulting in the limitation of blood flow. (
  • A continuous forced flow electrophoresis cell and a method of operation for the fractionation of an aqueous liquid, such as blood, containing at least two compounds, the relative mobilities of which in an electric field vary as a function of the pH, in order to obtain one fraction enriched and one depleted. (
  • During the separating step, the method accumulates a second separated blood component in the interface without withdrawal from the rotating chamber by monitoring the location of the interface within the rotating chamber and maintaining the interface at a location spaced away from flow communication with both the first and second outlet pods. (
  • After a selected time period, the method shifts the location of the interface within the rotating chamber into flow communication with a selected outlet port and withdraws the second separated blood component from the rotating chamber through the selected outlet port. (
  • This does not let the blood flow towards the tag. (
  • To improve the quantitative assessment of cerebral blood volume (CBV) and flow (CBF) in the brain voxels from MR perfusion images. (
  • Parametric measurements, such as cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT), and time-to-peak (TTP), are used to evaluate local perfusions [ 1 - 5 ]. (
  • While detection and correction strategies for most of these physiological and systemic interferences are widely practiced, effect of scalp-hemodynamic and skin blood flow (SBF) has been subject to much divided perspective. (
  • One major issue regularly observed in publications from researchers new to the field is the failure to consider possible signal contamination by hemodynamic changes unrelated to neurovascular coupling (i.e., scalp blood flow and systemic blood flow). (
  • The downward flow of the blood drives the filtration process. (
  • Its function, which is not yet established, may be to regulate the rate of blood flow or to participate in the inflammatory response of an animal to injury. (
  • Systemic effects, such as blood pressure, respiratory and blood flow variation, alter relative blood oxyhemoglobin and deoxyhemoglobin concentrations. (
  • Central co-ordination of the case, particularly visits his blood flow. (
  • Chylomicrons exchange surface components with high-density lipoproteins (HDL) and acquire apo C-II and apo E in the process. (
  • Kidney, bone marrow or other organ biopsy Removal of a small sample of organ tissue. (
  • EXAMPLE: bone marrow aspiration - DIAGNOSISES: blood disorders such as anemia, pancytopenias, and leukemia. (
  • These include a recommendation that bone should be processed to remove blood and marrow and that pooling of donations is never advantageous. (
  • This work confirms that the majority of blood and marrow components can be removed without the need for morselising the bone prior to washing. (
  • Leukemia is a type of cancer that affects the blood and bone marrow. (
  • Heme is vital for all of the body's organs, although it is most abundant in the blood, bone marrow, and liver. (
  • This additional process will add another level of safety to the already established treatment protocols and is particularly relevant since there is no commercially available diagnostic test for detection of the blood-borne form of the vCJD agent. (
  • The PRDT prion removal technology is presently being used in the P-Capt(R) prion filter, CE marked in September 2006, and marketed by MacoPharma for the elimination of TSEs such as vCJD in red blood cell concentrates. (
  • The risk of transmission of CJD and vCJD by blood and blood products. (
  • Two cases of probable transmission of vCJD by blood components have now been reported. (
  • If proven in further studies using animal and human blood, it could be an a more effective alternative to the current practice in the U.S. and in Britain of screening blood donors for possible contacts with people who are known to have vCJD. (
  • In the Dec. 8 issue of The Lancet, British researchers reported a third case of vCJD in an at-risk group who were given tainted blood transfusions. (
  • Two other cases -- identified after death and reported two years ago -- were previously identified among 66 people who got blood transfusions from donors who subsequently developed vCJD, according to Stephen Wroe, M.D., of the National Prion Clinic at the National Hospital for Neurology and Neurosurgery in London. (
  • This study describes a potential method for removing the prion particles that can cause vCJD from donated blood. (
  • Reassure patients that in the United States and Canada the blood supply is safe, because donors are rigorously screened for potential exposure to vCJD, or mad-cow disease. (
  • The collection of blood from volunteer donors has become a very successful and very refined activity. (
  • Such sets have made possible large-scale collection of blood from volunteer donors at sites such as church halls, schools or offices which might be remote from medical facilities. (
  • In addition, they provide a potentially much larger reservoir of donarable blood than is available from the available group of paid donors. (
  • Integrated light microscope and MALDI IT-TOF mass spectrometer, together with a matrix sublimation device, were used for analysis of blood smears coming from healthy male donors. (
  • All donors are carefully screened to make sure there is a suitable blood type match and to prevent any transmissible diseases or other complications. (
  • Living donors must be physically fit, in good general health, and have no existing disorders such as diabetes, high blood pressure, cancer, kidney disease, or heart disease. (
  • The American Red Cross asks all potential blood donors whether they have ever had a blood relative with Creutzfeldt-Jakob disease, and whether they had lived in the United Kingdom for at least three months since 1980, whether they had received a blood transfusion in England since 1980, or whether they had traveled or lived in Europe for a cumulative five years or more since 1980. (
  • The leucocytes present in donated blood play no therapeutic role in transfusion and may be a cause of adverse transfusion reactions. (
  • Dynamic-susceptibility-contrast MR imaging is used to diagnose cerebral blood perfusion. (
  • Second, although the concentration-time curve measured in a venous voxel has been proposed to correct for the partial volume of blood in arterial voxels [ 14 , 15 ], the assumption that at least one venous voxel consists of 100% blood is not guaranteed for all MR brain perfusion studies [ 14 , 16 ]. (
  • As a result of this success, bacterial contamination of blood products has emerged as the greatest residual source of transfusion-transmitted disease. (
  • Given the reduction of viral transmission via allogeneic blood, the low but known risk of bacterial contamination has emerged as the greatest residual threat of transfusion-transmitted disease (Fig. 1 ). (
  • All platelet components from the Australian Red Cross Lifeblood are screened for bacterial contamination. (
  • Additionally, knowledge of potential bacterial contamination should enable early clinical review and consideration of antibiotic intervention in situations where components have already been transfused. (
  • This is especially the case with platelet components stored at room temperature as it has been demonstrated that cytokine production occurs more rapidly at 20 °C than 4 °C. (
  • However, studies relating to bacterial growth in platelet components are much less convincing. (
  • Apo E is required for the normal removal of triglyceride-rich particles from the blood via hepatic apo E receptors. (
  • In the current study, Dr. Rohwer and colleagues looked at the ability of affinity resin chromatography to remove infectious prion particles from the blood of hamsters infected with scrapie. (
  • Careful analysis of the person's blood and physical condition help to determine the stage of the disease - a crucial first step in deciding on the proper course of treatment. (
  • Over the last 20 years, astounding reductions in the risk of viral infection via allogeneic blood have been achieved. (
  • Allogeneic blood for transfusion is a potential source of infection by a variety of known and unknown transmissible agents. (
  • To this end, astounding reductions in the viral risk of allogeneic blood has been accomplished ( 27 ). (
  • 5. A method in accordance with claim 1 or 3 wherein said withdrawn blood is formed into an extracorporeal flowing stream, passed through a treatment station whereat said irradiation is effected and returned to said subject in a continuous operation. (
  • Abdominal sarcomas can extend to involve nearby organs, requiring removal or presurgical treatment. (
  • Also, blood has to be in the right places at the right times, at the right temperature and pressure, and it carries regulatory messages between organs via blood 'messengers' called hormones. (
  • It is important to develop an instrument wherein blood parameters can be calculated which will be non-invasive, user friendly, portable and reliable. (
  • Third, the phase between blood and tissues can cause signal cancellation in the voxels that consist of both blood and tissues [ 17 ]. (
  • Fourth, the changes in MR relativity are different in tissues and blood [ 18 , 19 ]. (
  • claimed that such changes are highly correlated with blood oxygen level dependent (BOLD) of functional magnetic resonance imaging (fMRI) and gray matter, as opposed to SBF or other soft tissues. (
  • Haemoglobin in the blood carries oxygen from the lungs or gills to the rest of the body (i.e. the tissues). (
  • A recirculation system is provided so that blood flows at a reduced rate through the processing system during the return cycle in order to minimize return cycle time while maintaining the stable position of the interface between buffy coat and red blood cell layers. (
  • Although there are over 600 known red blood cell antigens organized into 22 blood group systems, routine blood typing is usually concerned with only two systems: the ABO and Rh blood group systems. (
  • Antibody screening helps to identify antibodies against several other groups of red blood cell antigens. (
  • Appropriate testing to ensure a match of red blood cell type (A, B, AB, or O) is essential. (
  • The carotid glands are stimulated by a decrease in the oxygen content of the blood and are considered to be the source of a substance, the nature of which has not yet been established with certainty, that promotes the process of red blood cell formation (erythropoiesis). (
  • Others enter the blood through leakage from cell damage and cell death. (
  • Despite this large number, sepsis associated with the transfusion of bacterially contaminated red cell blood components is generally regarded as a very rare event. (
  • Blood is fundamental to the function of every cell of every component in our bodies. (
  • Next, 2-propranol and water was added to red blood cell aliquots and mixture was centrifuged. (
  • The method withdraws the first separated blood component out of the rotating chamber. (
  • In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via. (
  • The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. (
  • Further processing produces blood products used to treat blood disorders or to replace blood lost through surgery or an accident. (
  • This paper summarizes the current status of detection, prevention, and elimination of bacteria in blood products for transfusion. (
  • Blood provides this coordinated environment by regulating acidity/alkalinity (pH), providing oxygen (and removing carbon dioxide and other waste products), and carrying essential vitamins and minerals. (
  • Cleaning is the removal of foreign material (e.g., soil, and organic material) from objects and is normally accomplished using water with detergents or enzymatic products. (
  • The models which they call "tubuloids," are formed from kidney tubules, which are an essential component of the kidney, functioning to filter waste products from the blood and eventually leading to their removal from the body via urine. (
  • Many of these products are specifically made for skin tag removal. (
  • Glands that secrete their products directly into the blood stream rather than into ducts. (
  • Acute bronchitis, unfractionated products of intra-ocular or components of calcitonin. (
  • Units designed for warming blood products and IV solutions. (
  • FNHTR are caused not only by leucocyte antigen-antibody reactions but also by the cytokines produced by leucocytes in the transfused blood component. (
  • This would be more effectively prevented if the leucocytes were removed immediately after the blood is collected, avoiding the formation of cytokines. (
  • Leucodepletion of blood components removes ≥ 99% of contaminating leucocytes resulting in a reduction in the leucocyte count to less than 1 x 10 6 per unit. (
  • The blood circulates through a machine that separates it into its components. (
  • Protocol Design: This protocol is designed to perform collection of human specimens, such as blood, mucosal secretions, skin swabs, skin biopsy, or body fluids to support research studies. (
  • Skin biopsy Removal of a small skin sample for microscopic analysis. (
  • If the blood glucose ever drops too much, we lose consciousness. (
  • This system uses the hormone glucagon (also from the pancreas) and it works by releasing glucose into the blood from stores located mostly in the liver. (
  • Glucagon is released when blood glucose levels are low, stimulating the liver to convert stored glycogen into glucose and release it into the blood stream. (
  • Boosts blood pH to be able to assistance neutralize uric acid as well as help avoid uric acid stone make-up in the kidneys. (
  • 4. - 5 In this paper, we use the term global components to denote the combined systemic components not associated with task-specific activity in fNIRS data. (
  • I am also collaborating with Drs. Daniel Haber and Mehmet Toner to define cancer biology across several tumor types including breast, prostate, liver and lung cancers as well as melanoma using CTCs isolated from the blood of cancer patients. (
  • Removal of amyloid from the liver was associated with improved function. (
  • This phase effect is TE dependent and can cause unexpected signal changes in arterial voxels that do not consist of 100% blood. (
  • It is important to consider, however, the fact that the level of removal of the viruses is dependent on the size of the pores of the nanofilter. (
  • Emitted infrared lights are differentially absorbed by oxyhemoglobin and deoxyhemoglobin and relative concentrations of blood oxyhemoglobin and deoxyhemoglobin are measured, 1 providing a noninvasive technique for measuring blood oxygen level dependent (BOLD) responses to neuronal activation in the cerebral cortex. (
  • Accidental consumption or overdoses of the anticoagulant drug warfarin can lead to a deficiency of the vitamin K-dependent blood-clotting proteins and a serious bleeding tendency. (
  • Physiologic monitoring systems that detect and display ECG's, respiratory rate, non-invasive and invasive blood pressure, body temperature, airway gas concentrations, and others. (
  • You can buy any product that's labeled as a USB charging pen for skin tag or mole removal. (
  • Examples of dry materials: Biologically contaminated laboratory materials, blood soiled articles, cultures, petri dishes containing media and stocks of infectious agents. (
  • Blood typing and screening tests are performed in a blood bank laboratory by technologists trained in blood bank and transfusion services. (
  • Leucocyte depletion may be performed before storage (at the blood collection centre) or after storage (in the hospital laboratory or at the bedside). (
  • Inflammatory mediators include blackening of the removal from coronary heart disease and treating the use which may be justified. (
  • Blood and urine samples and cardiovascular testing will also be collected or performed on healthy volunteers for research purposes and to support the identification and validation of new biomarker candidates. (