Blood coagulation. Medical search

The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.

Endogenous substances, usually proteins, that are involved in the blood coagulation process.

Laboratory tests for evaluating the individual's clotting mechanism.

A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.

Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.

Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.

Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. It catalyzes the conversion of prothrombin to thrombin in conjunction with other cofactors.

Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.

Heat- and storage-stable plasma protein that is activated by tissue thromboplastin to form factor VIIa in the extrinsic pathway of blood coagulation. The activated form then catalyzes the activation of factor X to factor Xa.

The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.

Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder.

A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.

Storage-stable blood coagulation factor acting in the intrinsic pathway. Its activated form, IXa, forms a complex with factor VIII and calcium on platelet factor 3 to activate factor X to Xa. Deficiency of factor IX results in HEMOPHILIA B (Christmas Disease).

Use of a thrombelastograph, which provides a continuous graphic record of the physical shape of a clot during fibrin formation and subsequent lysis.

Activated form of factor VII. Factor VIIa activates factor X in the extrinsic pathway of blood coagulation.

An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.

A fibrin-stabilizing plasma enzyme (TRANSGLUTAMINASES) that is activated by THROMBIN and CALCIUM to form FACTOR XIIIA. It is important for stabilizing the formation of the fibrin polymer (clot) which culminates the coagulation cascade.

The time required by whole blood to produce a visible clot.

Activated form of factor XI. In the intrinsic pathway, Factor XI is activated to XIa by factor XIIa in the presence of cofactor HMWK; (HIGH MOLECULAR WEIGHT KININOGEN). Factor XIa then activates factor IX to factor IXa in the presence of calcium.

Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.

The natural enzymatic dissolution of FIBRIN.

Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These are the carboxylating enzymes and are mostly biotinyl-proteins. EC 6.4.

Agents that cause clotting.

A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily.

The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.

A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.

Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.

Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.

Activated form of factor IX. This activation can take place via the intrinsic pathway by the action of factor XIa and calcium, or via the extrinsic pathway by the action of factor VIIa, thromboplastin, and calcium. Factor IXa serves to activate factor X to Xa by cleaving the arginyl-leucine peptide bond in factor X.

Starches that have been chemically modified so that a percentage of OH groups are substituted with 2-hydroxyethyl ether groups.

Clotting time of PLASMA mixed with a THROMBIN solution. It is a measure of the conversion of FIBRINOGEN to FIBRIN, which is prolonged by AFIBRINOGENEMIA, abnormal fibrinogen, or the presence of inhibitory substances, e.g., fibrin-fibrinogen degradation products, or HEPARIN. BATROXOBIN, a thrombin-like enzyme unaffected by the presence of heparin, may be used in place of thrombin.

Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.

Agents that prevent clotting.

A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.

Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.

Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.

Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is often called hemophilia C.

A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.

A hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia.

Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.

An absence or reduced level of blood coagulation factor XII. It normally occurs in the absence of patient or family history of hemorrhagic disorders and is marked by prolonged clotting time.

Soluble protein fragments formed by the proteolytic action of plasmin on fibrin or fibrinogen. FDP and their complexes profoundly impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinolysis.

Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va.

Formation and development of a thrombus or blood clot in the blood vessel.

Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.

Activated form of factor V. It is an essential cofactor for the activation of prothrombin catalyzed by factor Xa.

A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.

A cell surface glycoprotein of endothelial cells that binds thrombin and serves as a cofactor in the activation of protein C and its regulation of blood coagulation.

The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.

Found in various tissues, particularly in four blood-clotting proteins including prothrombin, in kidney protein, in bone protein, and in the protein present in various ectopic calcifications.

The most common mineral of a group of hydrated aluminum silicates, approximately H2Al2Si2O8-H2O. It is prepared for pharmaceutical and medicinal purposes by levigating with water to remove sand, etc. (From Merck Index, 11th ed) The name is derived from Kao-ling (Chinese: "high ridge"), the original site. (From Grant & Hackh's Chemical Dictionary, 5th ed)

The vitamin K-dependent cofactor of activated PROTEIN C. Together with protein C, it inhibits the action of factors VIIIa and Va. A deficiency in protein S; (PROTEIN S DEFICIENCY); can lead to recurrent venous and arterial thrombosis.

A method of tissue ablation and bleeding control that uses ARGON plasma (ionized argon gas) to deliver a current of thermocoagulating energy to the area of tissue to be coagulated.

A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in detail, not the holy day.) Historical and clinical features resemble those in classic hemophilia (HEMOPHILIA A), but patients present with fewer symptoms. Severity of bleeding is usually similar in members of a single family. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Treatment is similar to that for hemophilia A. (From Cecil Textbook of Medicine, 19th ed, p1008)

Hemorrhagic and thrombotic disorders that occur as a consequence of inherited abnormalities in blood coagulation.

Absence or reduced levels of PROTHROMBIN in the blood.

Hemorrhagic and thrombotic disorders resulting from abnormalities or deficiencies of coagulation proteins.

A plasma protein which is the precursor of kallikrein. Plasma that is deficient in prekallikrein has been found to be abnormal in thromboplastin formation, kinin generation, evolution of a permeability globulin, and plasmin formation. The absence of prekallikrein in plasma leads to Fletcher factor deficiency, a congenital disease.

Two small peptide chains removed from the N-terminal segment of the alpha chains of fibrinogen by the action of thrombin during the blood coagulation process. Each peptide chain contains 18 amino acid residues. In vivo, fibrinopeptide A is used as a marker to determine the rate of conversion of fibrinogen to fibrin by thrombin.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A nutritional condition produced by a deficiency of VITAMIN K in the diet, characterized by an increased tendency to hemorrhage (HEMORRHAGIC DISORDERS). Such bleeding episodes may be particularly severe in newborn infants. (From Cecil Textbook of Medicine, 19th ed, p1182)

A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Exogenous or endogenous compounds which inhibit SERINE ENDOPEPTIDASES.

The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.

Blood coagulation disorder usually inherited as an autosomal recessive trait, though it can be acquired. It is characterized by defective activity in both the intrinsic and extrinsic pathways, impaired thromboplastin time, and impaired prothrombin consumption.

A family of snakes comprising three subfamilies: Azemiopinae (the mountain viper, the sole member of this subfamily), Viperinae (true vipers), and Crotalinae (pit vipers). They are widespread throughout the world, being found in the United States, Central and South America, Europe, Asia and Africa. Their venoms act on the blood (hemotoxic) as compared to the venom of elapids which act on the nervous system (neurotoxic). (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, pp333-36)

Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.

The use of green light-producing LASERS to stop bleeding. The green light is selectively absorbed by HEMOGLOBIN, thus triggering BLOOD COAGULATION.

Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Bleeding or escape of blood from a vessel.

A 3.5 per cent colloidal solution containing urea-cross-linked polymerized peptides. It has a molecular weight of approximately 35,000 and is prepared from gelatin and electrolytes. The polymeric solution is used as a plasma expander.

The rate dynamics in chemical or physical systems.

Proteins prepared by recombinant DNA technology.

Procedures using an electrically heated wire or scalpel to treat hemorrhage (e.g., bleeding ulcers) and to ablate tumors, mucosal lesions, and refractory arrhythmias. It is different from ELECTROSURGERY which is used more for cutting tissue than destroying and in which the patient is part of the electric circuit.

A family of ark shell mollusks, in the class BIVALVIA. They have soft bodies with platelike GILLS enclosed within two shells hinged together.

Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifically, Kallikreins are potent vasodilators and hypotensives and increase vascular permeability and affect smooth muscle. They act as infertility agents in men. Three forms are recognized, PLASMA KALLIKREIN (EC 3.4.21.34), TISSUE KALLIKREIN (EC 3.4.21.35), and PROSTATE-SPECIFIC ANTIGEN (EC 3.4.21.77).

A member of the serpin superfamily found in plasma that inhibits the lysis of fibrin clots which are induced by plasminogen activator. It is a glycoprotein, molecular weight approximately 70,000 that migrates in the alpha 2 region in immunoelectrophoresis. It is the principal plasmin inactivator in blood, rapidly forming a very stable complex with plasmin.

An autosomal recessive characteristic or a coagulation disorder acquired in association with VITAMIN K DEFICIENCY. FACTOR VII is a Vitamin K dependent glycoprotein essential to the extrinsic pathway of coagulation.

A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.

The number of PLATELETS per unit volume in a sample of venous BLOOD.

Physiologically inactive substances that can be converted to active enzymes.

Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.

An order of nematodes of the subclass SECERNENTEA. Its organisms are characterized by a single, ventral excretory gland and a relatively stout, short body.

Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.

Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders.

A peptidohydrolytic enzyme that is formed from PREKALLIKREIN by FACTOR XIIA. It activates FACTOR XII; FACTOR VII; and PLASMINOGEN. It is selective for both ARGININE and to a lesser extent LYSINE bonds. EC 3.4.21.34.

Limbless REPTILES of the suborder Serpentes.

Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.

Duration of blood flow after skin puncture. This test is used as a measure of capillary and platelet function.

Enzymes that catalyze the joining of two molecules by the formation of a carbon-carbon bond. These are the carboxylating enzymes and are mostly biotinyl-proteins. EC 6.4.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

A thrombin receptor subtype that couples to HETEROTRIMERIC GTP-BINDING PROTEINS resulting in the activation of a variety of signaling mechanisms including decreased intracellular CYCLIC AMP, increased TYPE C PHOSPHOLIPASES and increased PHOSPHOLIPASE A2.

A plant genus of the family MORACEAE. Puag-haad extract, from A. lakoocha, contains STILBENES and related 4-substituted RESORCINOLS.

Reduction of blood viscosity usually by the addition of cell free solutions. Used clinically (1) in states of impaired microcirculation, (2) for replacement of intraoperative blood loss without homologous blood transfusion, and (3) in cardiopulmonary bypass and hypothermia.

Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.

GLYCOSPHINGOLIPIDS with a sulfate group esterified to one of the sugar groups.

Precursor of plasmin (FIBRINOLYSIN). It is a single-chain beta-globulin of molecular weight 80-90,000 found mostly in association with fibrinogen in plasma; plasminogen activators change it to fibrinolysin. It is used in wound debriding and has been investigated as a thrombolytic agent.

Activated form of FACTOR XIII, a transglutaminase, which stabilizes the formation of the fibrin polymer (clot) culminating the blood coagulation cascade.

Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.

A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.

Serum proteins that inhibit, antagonize, or inactivate COMPLEMENT C1 or its subunits.

Amidines substituted with a benzene group. Benzamidine and its derivatives are known as peptidase inhibitors.

An arthropod subclass (Xiphosura) comprising the North American (Limulus) and Asiatic (Tachypleus) genera of horseshoe crabs.

Elements of limited time intervals, contributing to particular results or situations.

Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (BLOOD COAGULATION DISORDERS) or another abnormality causing a structural flaw in the blood vessels (HEMOSTATIC DISORDERS).

A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.

Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.

Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.

Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.

Proteins synthesized by organisms belonging to the phylum ARTHROPODA. Included in this heading are proteins from the subdivisions ARACHNIDA; CRUSTACEA; and HORSESHOE CRABS. Note that a separate heading for INSECT PROTEINS is listed under this heading.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

A fused four ring compound occurring free or combined in galls. Isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used in research and as a dye.

Inflammation of a vein associated with a blood clot (THROMBUS).

Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms.

Hormones produced by invertebrates, usually insects, mollusks, annelids, and helminths.

The sum of the weight of all the atoms in a molecule.

Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.

Solutions or mixtures of toxic and nontoxic substances elaborated by snake (Ophidia) salivary glands for the purpose of killing prey or disabling predators and delivered by grooved or hollow fangs. They usually contain enzymes, toxins, and other factors.

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

A family of soil bacteria. It also includes some parasitic forms.

The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.

Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other "foreign" surfaces.

A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. Light is then focused on the opposite side of the film to excite the surface plasmons, that is, the oscillations of free electrons propagating along the film's surface. The refractive index of light reflecting off this surface is measured. When the immobilized biomolecules are bound by their ligands, an alteration in surface plasmons on the opposite side of the film is created which is directly proportional to the change in bound, or adsorbed, mass. Binding is measured by changes in the refractive index. The technique is used to study biomolecular interactions, such as antigen-antibody binding.

Arginine derivative which is a substrate for many proteolytic enzymes. As a substrate for the esterase from the first component of complement, it inhibits the action of C(l) on C(4).

A class of receptors that are activated by the action of PROTEINASES. The most notable examples are the THROMBIN RECEPTORS. The receptors contain cryptic ligands that are exposed upon the selective proteolysis of specific N-terminal cleavage sites.

Venoms from SNAKES of the viperid family. They tend to be less toxic than elapid or hydrophid venoms and act mainly on the vascular system, interfering with coagulation and capillary membrane integrity and are highly cytotoxic. They contain large amounts of several enzymes, other factors, and some toxins.

An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.

An infant born at or after 42 weeks of gestation.

Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.

A genus of snakes of the family VIPERIDAE. It is distributed in West Pakistan, most of India, Burma, Ceylon, Thailand, southeast China, Taiwan, and a few islands of Indonesia. It hisses loudly when disturbed and strikes with great force and speed. Very prolific, it gives birth to 20-60 young. This viper is the leading cause of snakebite in India and Burma. (Moore: Poisonous Snakes of the World, 1980, p127)

Poisonous animal secretions forming fluid mixtures of many different enzymes, toxins, and other substances. These substances are produced in specialized glands and secreted through specialized delivery systems (nematocysts, spines, fangs, etc.) for disabling prey or predator.

Substances that display the physical properties of ELASTICITY and VISCOSITY. The dual-nature of these substances causes them to resist applied forces in a time-dependent manner.

Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.

The formation or presence of a blood clot (THROMBUS) within a vein.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.

Linear polymers in which orthophosphate residues are linked with energy-rich phosphoanhydride bonds. They are found in plants, animals, and microorganisms.

A genus of venomous snakes of the subfamily Crotalinae. Twelve species of this genus are found in North and Central America and Asia. Agkistrodon contortrix is the copperhead, A. piscivorus, the cottonmouth. The former is named for its russet or orange-brown color, the latter for the white interior of its mouth. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p336; Moore, Poisonous Snakes of the World, 1980, p75)

A clinical condition resulting from repeated physical and psychological injuries inflicted on a child by the parents or caregivers.

Extracellular vesicles generated by the shedding of CELL MEMBRANE blebs.

Important modulators of the activity of plasminogen activators. The inhibitors belong to the serpin family of proteins and inhibit both the tissue-type and urokinase-type plasminogen activators.

A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.

Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.

A genus of poisonous snakes of the VIPERIDAE family. About 50 species are known and all are found in tropical America and southern South America. Bothrops atrox is the fer-de-lance and B. jararaca is the jararaca. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p336)

Proteins and peptides found in SALIVA and the SALIVARY GLANDS. Some salivary proteins such as ALPHA-AMYLASES are enzymes, but their composition varies in different individuals.

A member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.

Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.

Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.

The coagulation of tissue by an intense beam of light, including laser (LASER COAGULATION). In the eye it is used in the treatment of retinal detachments, retinal holes, aneurysms, hemorrhages, and malignant and benign neoplasms. (Dictionary of Visual Science, 3d ed)

A genus of leguminous shrubs or trees, mainly tropical, yielding useful compounds such as ALKALOIDS and PLANT LECTINS.

The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.

A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.

The study of fluid channels and chambers of tiny dimensions of tens to hundreds of micrometers and volumes of nanoliters or picoliters. This is of interest in biological MICROCIRCULATION and used in MICROCHEMISTRY and INVESTIGATIVE TECHNIQUES.

A galanin receptor subtype with broad specificity for full length GALANIN, galanin peptide fragments and GALANIN-LIKE PEPTIDE.

A deficiency or absence of FIBRINOGEN in the blood.

A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

The relationship between the dose of an administered drug and the response of the organism to the drug.

A family of serine proteinase inhibitors which are similar in amino acid sequence and mechanism of inhibition, but differ in their specificity toward proteolytic enzymes. This family includes alpha 1-antitrypsin, angiotensinogen, ovalbumin, antiplasmin, alpha 1-antichymotrypsin, thyroxine-binding protein, complement 1 inactivators, antithrombin III, heparin cofactor II, plasminogen inactivators, gene Y protein, placental plasminogen activator inhibitor, and barley Z protein. Some members of the serpin family may be substrates rather than inhibitors of SERINE ENDOPEPTIDASES, and some serpins occur in plants where their function is not known.

A sulfated pentosyl polysaccharide with heparin-like properties.

A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.

OXIDOREDUCTASES which mediate vitamin K metabolism by converting inactive vitamin K 2,3-epoxide to active vitamin K.

A di-isopropyl-fluorophosphate which is an irreversible cholinesterase inhibitor used to investigate the NERVOUS SYSTEM.

A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.

Laboratory and other services provided to patients at the bedside. These include diagnostic and laboratory testing using automated information entry.

A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)

Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

Large members of the FALCONIFORMES order of birds, family Accipitridae, most especially the genera Aquila, Haliaeetus, Harpia, and Circaetus. They are characterized by their powerful talons, which carry long, curved, pointed claws and by their opposable hindtoe.

A group of substances similar to VITAMIN K 1 which contains a ring of 2-methyl-1,4-naphthoquinione and an isoprenoid side chain of varying number of isoprene units. In vitamin K 2, each isoprene unit contains a double bond. They are produced by bacteria including the normal intestinal flora.

The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.

A foul-smelling diamine formed by bacterial decarboxylation of lysine.

Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

A salt used to replenish calcium levels, as an acid-producing diuretic, and as an antidote for magnesium poisoning.

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

Family of calcium- and phospholipid-binding proteins which are structurally related and exhibit immunological cross-reactivity. Each member contains four homologous 70-kDa repeats. The annexins are differentially distributed in vertebrate tissues (and lower eukaryotes) and appear to be involved in MEMBRANE FUSION and SIGNAL TRANSDUCTION.

The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.

A deficiency of blood coagulation FACTOR XIII or fibrin stabilizing factor (FSF) that prevents blood clot formation and results in a clinical hemorrhagic diathesis.

Two-phase systems in which one is uniformly dispersed in another as particles small enough so they cannot be filtered or will not settle out. The dispersing or continuous phase or medium envelops the particles of the discontinuous phase. All three states of matter can form colloids among each other.

Venous vessels in the umbilical cord. They carry oxygenated, nutrient-rich blood from the mother to the FETUS via the PLACENTA. In humans, there is normally one umbilical vein.

Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.

A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.

Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).

Peptides composed of between two and twelve amino acids.

Control of bleeding during or after surgery.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

Established cell cultures that have the potential to propagate indefinitely.

Chemical groups containing the covalent disulfide bonds -S-S-. The sulfur atoms can be bound to inorganic or organic moieties.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).

Exosites 1 and 2 are essential for protection of fibrin-bound thrombin from heparin-catalyzed inhibition by antithrombin and heparin cofactor II. (1/3556)

Assembly of ternary thrombin-heparin-fibrin complexes, formed when fibrin binds to exosite 1 on thrombin and fibrin-bound heparin binds to exosite 2, produces a 58- and 247-fold reduction in the heparin-catalyzed rate of thrombin inhibition by antithrombin and heparin cofactor II, respectively. The greater reduction for heparin cofactor II reflects its requirement for access to exosite 1 during the inhibitory process. Protection from inhibition by antithrombin and heparin cofactor II requires ligation of both exosites 1 and 2 because minimal protection is seen when exosite 1 variants (gamma-thrombin and thrombin Quick 1) or an exosite 2 variant (Arg93 --> Ala, Arg97 --> Ala, and Arg101 --> Ala thrombin) is substituted for thrombin. Likewise, the rate of thrombin inhibition by the heparin-independent inhibitor, alpha1-antitrypsin Met358 --> Arg, is decreased less than 2-fold in the presence of soluble fibrin and heparin. In contrast, thrombin is protected from inhibition by a covalent antithrombin-heparin complex, suggesting that access of heparin to exosite 2 of thrombin is hampered when ternary complex formation occurs. These results reveal the importance of exosites 1 and 2 of thrombin in assembly of the ternary complex and the subsequent protection of thrombin from inhibition by heparin-catalyzed inhibitors. (+info)

Nonanticoagulant heparin prevents coronary endothelial dysfunction after brief ischemia-reperfusion injury in the dog. (2/3556)

BACKGROUND: Coronary endothelial dysfunction after brief ischemia-reperfusion (IR) remains a clinical problem. We investigated the role of heparin and N-acetylheparin, a nonanticoagulant heparin derivative, in modulating coronary endothelial function after IR injury, with an emphasis on defining the role of the nitric oxide (NO)-cGMP pathway in the heparin-mediated effect. METHODS AND RESULTS: Male mongrel dogs were surgically instrumented, and the effects of both bovine heparin and N-acetylheparin on coronary endothelial vasomotor function, expressed as percent change from baseline flow after acetylcholine challenge, were studied after 15 minutes of regional ischemia of the left anterior descending artery (LAD) followed by 120 minutes of reperfusion. In dogs treated with placebo (saline), coronary vasomotor function was significantly (P+info)

Distinct contributions of residue 192 to the specificity of coagulation and fibrinolytic serine proteases. (3/3556)

Archetypal members of the chymotrypsin family of serine proteases, such as trypsin, chymotrypsin, and elastase, exhibit relatively broad substrate specificity. However, the successful development of efficient proteolytic cascades, such as the blood coagulation and fibrinolytic systems, required the evolution of proteases that displayed restricted specificity. Tissue-type plasminogen activator (t-PA), for example, possesses exquisitely stringent substrate specificity, and the molecular basis of this important biochemical property of t-PA remains obscure. Previous investigations of related serine proteases, which participate in the blood coagulation cascade, have focused attention on the residue that occupies position 192 (chymotrypsin numbering system), which plays a pivotal role in determining both the inhibitor and substrate specificity of these enzymes. Consequently, we created and characterized the kinetic properties of new variants of t-PA that contained point mutations at position 192. These studies demonstrated that, unlike in coagulation serine proteases, Gln-192 does not contribute significantly to the substrate or inhibitor specificity of t-PA in physiologically relevant reactions. Replacement of Gln-192 with a glutamic acid residue did, however, decrease the catalytic efficiency of mature, two-chain t-PA toward plasminogen in the absence of a fibrin co-factor. (+info)

Age-related changes in blood coagulation and fibrinolysis in mice fed on a high-cholesterol diet. (4/3556)

To investigate the pathogenesis of hyperlipidemia-induced atherosclerosis, we examined age-dependent changes in platelet activity, blood coagulation and fibrinolysis in susceptibility to a high cholesterol diet (HCD) feeding in male ICR mice. Pretreatment of platelet-rich-plasma from HCD feeding mice for 3 days with epinephrine (300 microM) resulted in a marked enhancement of adenosine 5'-diphosphate (ADP: 0.1 microM) or collagen (0.7 microgram/ml)-stimulated aggregation compared with the same in control mice. Yohimbine as alpha 2-adrenergic blocker antagonized these aggregations in a dose-dependent manner. A significant increase in plasma total cholesterol and VLDL (very low-density lipoprotein)-LDL (low-density lipoprotein)-cholesterol and the liver/body weight ratio was observed in mice fed on HCD for 3 months (3-month HCD mice). In the early phase of this experiment, a significant increase in fibrinogen was observed. In the middle phase, increases in the activity of antithrombin III (ATIII) and alpha 2-plasmin inhibitor (alpha 2-Pl) followed. Plasminogen content gradually decreased in both normal diet and HCD mice throughout the experiment. The activity of plasminogen activator inhibitor (PAI) decreased in 3-month HCD mice. Morphological observation of the aortic arch from 3-month HCD mice revealed apparent atheromatous plaques not seen in control mice. These results suggest that 3-month HCD mice can be a convenient hyperlipidemia-induced atherosclerotic model and the changes in platelet activity, coagulation and fibrinolysis in the early phase may be a cause of pathologic changes in this model. (+info)

PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. (5/3556)

Plasminogen activator inhibitor type-1 (PAI-1) is a major physiological inhibitor of fibrinolysis, with its plasma levels correlating with the risk for myocardial infarction and venous thrombosis. The regulation of PAI-1 transcription by endothelial cells (ECs), a major source of PAI-1, remains incompletely understood. Adipocytes also produce PAI-1, suggesting possible common regulatory pathways between adipocytes and ECs. Peroxisomal proliferator-activated receptor-gamma (PPAR)gamma is a ligand-activated transcription factor that regulates gene expression in response to various mediators such as 15-deoxy-Delta12, 14-prostaglandin J2 (15d-PGJ2) and oxidized linoleic acid (9- and 13-HODE). The present study tested the hypotheses that human ECs express PPARgamma and that this transcriptional activator regulates PAI-1 expression in this cell type. We found that human ECs contain both PPARgamma mRNA and protein. Immunohistochemistry of human carotid arteries also revealed the presence of PPARgamma in ECs. Bovine ECs transfected with a PPAR response element (PPRE)-luciferase construct responded to stimulation by the PPARgamma agonist 15d-PGJ2 in a concentration-dependent manner, suggesting a functional PPARgamma in ECs. Treatment of human ECs with 15d-PGJ2, 9(S)-HODE, or 13(S)-HODE augmented PAI-1 mRNA and protein expression, whereas multiple PPARalpha activators did not change PAI-1 levels. Introduction of increasing amounts of a PPARgamma expression construct in human fibroblasts enhanced PAI-1 secretion from these cells in proportion to the amount of transfected DNA. Thus, ECs express functionally active PPARgamma that regulates PAI-1 expression in ECs. Our results establish a role for PPARgamma in the regulation of EC gene expression, with important implications for the clinical links between obesity and atherosclerosis. (+info)

Antithrombotic efficacy of thrombin inhibitor L-374,087: intravenous activity in a primate model of venous thrombus extension and oral activity in a canine model of primary venous and coronary artery thrombosis. (6/3556)

The small molecule direct thrombin inhibitor L-374,087 was characterized across species in an in vitro activated partial thromboplastin clotting time (aPTT) assay and in vivo in rhesus monkey and dog thrombosis models. In vitro in rhesus, dog, and human plasma, L-374,087 concentrations eliciting 2-fold increases in aPTT were 0.25, 1.9, and 0.28 microM, respectively. In anesthetized rhesus monkeys, 300 microgram/kg bolus plus 12 microgram/kg/min and 300 microgram/kg bolus plus 30 microgram/kg/min L-374,087 i.v. infusions significantly reduced jugular vein thrombus extension, with both regimens limiting venous thrombus extension to 2-fold that of baseline thrombus mass compared with a 5-fold extension observed in the vehicle control group. Antithrombotic efficacy in the rhesus with the lower-dose regimen was achieved with 2.3- to 2.4-fold increases in aPTT and prothrombin time. In a conscious instrumented dog model of electrolytic vessel injury, the oral administration of two 10 mg/kg L-374,087 doses 12 h apart significantly reduced jugular vein thrombus mass, reduced the incidence of and delayed time to occlusive coronary artery thrombosis, and significantly reduced coronary artery thrombus mass and ensuing posterolateral myocardial infarct size. Antithrombotic efficacy in the dog was achieved with 1.6- to 2.0-fold increases in aPTT at 1 to 6 h after oral dosing with L-374,087. These results indicate significant antithrombotic efficacy against both venous and coronary arterial thrombosis with L-374,087 with only moderate elevations in aPTT or prothrombin time. The oral efficacy of L-374,087 characterizes this compound as a prototype for the further development of orally active direct thrombin inhibitors. (+info)

Risk of clot formation in femoral arterial sheaths maintained overnight for neuroangiographic procedures. (7/3556)

BACKGROUND AND PURPOSE: The purpose of this study was to evaluate the presence of blood clots in femoral arterial sheaths maintained after cerebral angiography and the effect of heparinized saline on clot formation. METHODS: Twenty-three sheaths were evaluated in 18 patients. Sheaths were maintained for 14 to 80 hours (average, 33 hours; median, 24 hours). After the sheaths were removed, they were vigorously flushed with 60 mL of normal saline and the number and size of clots found in each sheath were recorded. Additionally, patients' age, catheter size, presence of heparin, amount of time the sheath was kept in the artery, and patients' coagulation status were recorded. RESULTS: Clots were found in 17 (74%) of the 23 sheaths. Ten catheters had continuous heparin drip, of which seven (70%) sustained clots. Of the 13 sheaths without heparin, 10 sustained clots (77%). The difference was not statistically significant. The average number of clots was 2.2, and the maximal length of clots ranged from 0.5 to 105 mm. No thromboembolic complications associated with sheath placement were encountered in our patient population. CONCLUSION: Blood clots are present in the vast majority of intraarterial sheaths maintained after cerebral angiography. These clots constitute a risk of thromboembolic complications in the event of repeat angiography. Sheath exchange should be considered before obtaining repeat cerebral angiograms. (+info)

Thrombelastographic changes and early rebleeding in cirrhotic patients with variceal bleeding. (8/3556)

BACKGROUND: Routine coagulation tests do not necessarily reflect haemostasis in vivo in cirrhotic patients, particularly those who have bleeding varices. Thrombelastography (TEG) can provide a global assessment of haemostatic function from initial clot formation to clot dissolution. AIM: To evaluate TEG changes in cirrhotic patients with variceal bleeding and their association with early rebleeding. PATIENTS/METHODS: Twenty cirrhotic patients with active variceal bleeding had serial TEG and routine coagulation tests daily for seven days. The TEG variables before the day of rebleeding (n = 6) were compared with those of patients without rebleeding (n = 14). RESULTS: Baseline characteristics of the rebleeding and non-rebleeding groups were comparable apart from a higher incidence of uncontrolled infection on the day of rebleeding in the rebleeding group (p = 0.007). The patients in the rebleeding group were more hypocoagulable before the day of rebleeding as shown by longer r (42 v 24 mm, p < 0.001) and k (48 v 13 mm, p < 0.001) and smaller a (12 v 38 degrees, p < 0.001) compared with the mean of daily results of the non-rebleeding group. Routine coagulation tests, however, showed no significant differences between the two groups. CONCLUSION: The results of serial TEG measurements suggest that hypocoagulability may be associated with early rebleeding in cirrhotic patients. (+info)

Blood Coagulation & Fibrinolysis. 16 (1): 1-7. doi:10.1097/00001721-200501000-00001. PMID 15650539. S2CID 44664652. Melzer C, ... It binds to the fibrin component of the thrombus (blood clot) and selectively converts thrombus-bound plasminogen to plasmin, ...

https://en.wikipedia.org/wiki/Tenecteplase

Marsh, NA (July 1998). "Use of snake venom fractions in the coagulation laboratory". Blood Coagulation & Fibrinolysis. 9 (5): ... Blood Coagulation & Fibrinolysis. 1 (3): 259-66. doi:10.1097/00001721-199008000-00002. PMID 2129412. Laboratory testing for the ... Blood. 68 (4): 869-74. doi:10.1182/blood.V68.4.869.869. PMID 3092888. Exner, T; Papadopoulos, G; Koutts, J (August 1990). "Use ... Exner, T; Rickard, KA; Kronenberg, H (October 1975). "Studies on phospholipids in the action of a lupus coagulation inhibitor ...

https://en.wikipedia.org/wiki/Dilute_Russell's_viper_venom_time

Blood Coagulation and Fibrinolysis. 12 (2): 123-8. doi:10.1097/00001721-200103000-00006. PMID 11302474. S2CID 28411589. North ...

https://en.wikipedia.org/wiki/Lactarius

Blood Coagulation and Fibrinolysis. 12 (2): 123-8. doi:10.1097/00001721-200103000-00006. PMID 11302474. S2CID 28411589. ... and impaired coagulation. No definitive antidote for amatoxin poisoning is available, but some specific treatments have been ...

https://en.wikipedia.org/wiki/Amanita_virosa

"Five novel mutations in the gene for human blood coagulation factor V associated with type I factor V deficiency". Blood. 98 (2 ... Both Factor X and Factor V circulate in the blood as inactive precursors prior to activation by the coagulation cascade. The ... doi:10.1182/blood.V98.2.358. PMID 11435304. Auerswald G (2006). "Prophylaxis in rare coagulation disorders -- factor X ... Furie B, Furie BC (May 1988). "The molecular basis of blood coagulation". Cell. 53 (4): 505-18. doi:10.1016/0092-8674(88)90567- ...

https://en.wikipedia.org/wiki/Prothrombinase

Fibrinogen, a protein involved in blood coagulation. This disambiguation page lists articles associated with the title Factor I ...

https://en.wikipedia.org/wiki/Factor_I

Studies of snake venom on blood coagulation. Part I: The thromboserpentin (thrombin-like) enzyme in the venoms. Thromb. Res. 2 ... The venom has both proteolytic and neurotoxic components and contains hemotoxins with blood coagulant properties, similar to ...

https://en.wikipedia.org/wiki/Vipera_ammodytes

anticoagulin A substance antagonistic to the coagulation of blood. anus The posterior opening of the digestive tract. apex / ... hemophagy feeding on blood. herbiphagy feeding on herbaceous plants. hindwing (Anatomical feature) the pair of wings of a four- ... anemic Deficient in blood quantity or quality. anteclypeus the lower (anterior) portion of the clypeus of insects. antennae The ... anaplasmosis Infection with Anaplasma, a genus of Sporozoa that infests red blood cells. anasa wilt A wilt disease of cucurbits ...

https://en.wikipedia.org/wiki/Glossary_of_entomology_terms

"Disseminated Intravascular Coagulation , National Heart, Lung, and Blood Institute (NHLBI)". www.nhlbi.nih.gov. Retrieved 2018- ... By the third day of illness, the patient's fever had reached 102 °F (39 °C), blood pressure acutely narrow and hypotensive (74/ ... and suspected disseminated intravascular coagulation: an overactivity of clotting proteins that can lead to eventual hemorrhage ...

https://en.wikipedia.org/wiki/Black_Creek_Canal_orthohantavirus

These products regulate the coagulation cascade and movements of white blood cells. Macrophages presented in humans are able to ... vomiting blood and bleeding from the lungs can also be found. Prolongation of prothrombin time in coagulation testing is ... Leptospirosis is a blood infection caused by the bacteria Leptospira. Signs and symptoms can range from none to mild (headaches ... For those who are infected, a complete blood count may show a high white cell count and a low platelet count. When a low ...

https://en.wikipedia.org/wiki/Leptospirosis

... is a saline liquid used to prevent coagulation of blood. It is composed of 2.05% dextrose, 0.8% sodium ... For usage, an equal volume of blood is gently, but thoroughly, mixed with the solution. This solution is used to study in vitro ... It is also used to preserve blood cells from other sources. The test was invented in 1941 by the American Hematologist, John ... Bellows Alsever (1908-1978). Alsever, J. B., & Ainslie, R. B. (1941). A new method for the preparation of dilute blood plasma ...

https://en.wikipedia.org/wiki/Alsever's_solution

This treatment results in activation of the extrinsic pathway of blood coagulation.[medical citation needed] NovoSeven was ... and has similar characteristics and functions with the native blood factor VII. Coagulation factor VIIa (recombinant)-jncw ( ... In April 2020, coagulation factor VIIa (recombinant)-jncw (Sevenfact) was approved for use in the United States. rFVIIa is a ... Sevenfact [coagulation factor VIIa (recombinant)-jncw] is approved for use in the United States and is indicated for the ...

https://en.wikipedia.org/wiki/Recombinant_factor_VIIa

Blood coagulation experiments. Sigmund Rascher experimented with the effects of Polygal, a substance made from beet and apple ... This caused the blood cells to congeal, and the blood was studied. When the Nazis removed blood from someone, they often ... blood coagulation and phlegmon.[2] According to the indictments at the Subsequent Nuremberg Trials,[3][4] these experiments ... Circulation of blood was interrupted by tying off blood vessels at both ends of the wound to create a condition similar to that ...

https://en.wikipedia.org/wiki/Nazi_human_experimentation

Blood coagulation experiments[edit]. Rascher experimented with the effects of Polygal, a substance made from beet and apple ... He conducted deadly experiments on humans about high altitude, freezing and blood coagulation under SS leader Heinrich Himmler' ... pectin, which aided blood clotting. He predicted that the preventive use of Polygal tablets would reduce bleeding from gunshot ...

https://en.wikipedia.org/wiki/Sigmund_Rascher

Produced and released by platelets they activate blood coagulation factor XII which is essential for blood clot formation. ... In humans polyphosphates are shown to play a key role in blood coagulation. ... "Newly discovered mechanism by which blood clots form". physorg.com. December 10, 2009. Retrieved 13 December 2009. Roewe J, ... that contributes to leakage from the blood vessels and thrombosis. Bacterial-derived polyphosphates impair the host immune ...

https://en.wikipedia.org/wiki/Polyphosphate

Platelets assist in blood clotting and coagulate when there are damages blood vessels. This coagulation attempts to cease ... A sample of blood is drawn from a patient's arm. A small amount of platelets in blood smears compared to the normal range of ... This maintenance of water concentration in the blood is essential for maintaining blood pressure and is affected in nephritis. ... This large size of the platelets also affects their ability to bind to each other to seal damaged blood vessels and stop ...

https://en.wikipedia.org/wiki/Epstein_syndrome

His major contribution was in isolating fibrin, a key protein in the blood coagulation process. His Copley work came when he ... In 1773 he produced evidence for the concept of a cell membrane in red blood cells - however, this last work was largely ... Falconar repeated Hewson's experiments on the spleen and thymus and as a result re-published Hewson's work on red blood cells ... He also demonstrated that red blood cells were discoid, rather than spherical as had been previously supposed by Anton van ...

https://en.wikipedia.org/wiki/William_Hewson_(surgeon)

His hematology research included important work on blood coagulation, blood platelets, hemorrhagic diseases, and hemoglobins. ...

https://en.wikipedia.org/wiki/C._Lockard_Conley

Collagen as haemostat: When collagen interacts with platelets it causes a rapid coagulation of blood. This rapid coagulation ... Collagen bases haemostat reduces blood loss in tissues and helps manage bleeding in cellular organs like the liver and spleen. ...

https://en.wikipedia.org/wiki/Biopolymer

Previously, to monitor coagulation effects, blood was placed in a glass tube, kept at 37 degrees Celsius, and manually ... Typically a sample of blood is put in a vial or cartridge along with coagulation activators. The sample is maintained at a ... Activated clotting time (ACT), also known as activated coagulation time, is a test of coagulation. The ACT test can be used to ... The coagulation end point can be determined by the optical (e.g., increased opacity detected by optical sensor) or mechanical ...

https://en.wikipedia.org/wiki/Activated_clotting_time

Together with integrin receptor α2β1 they provide coagulation cascade activation when a blood-vessel is damaged. When damage ... They control mainly cell proliferation, migration and adhesion, coagulation cascade activation and they affect ECM structure by ... This interaction activates signalling cascades leading to coagulation factors release. Mainly fibrillar collagens type I and ...

https://en.wikipedia.org/wiki/Collagen_receptor

It is used to diagnose blood coagulation disorders and to assess the effectiveness of fibrinolytic therapy. This test is ... is a blood test that measures the time it takes for a clot to form in the plasma of a blood sample containing anticoagulant, ... or under-filled in order to ensure the correct anticoagulant-to-blood ratio: one part anticoagulant per nine parts blood.[ ... In blood samples containing heparin, a substance derived from snake venom called batroxobin (formerly reptilase) is used ...

https://en.wikipedia.org/wiki/Thrombin_time

The inhibition of blood coagulation reduces resultant fibrinolysis, which would cause cell death and increase local ... PSGAG reaches peak blood concentration in 20-40 minutes when injected intramuscularly; 30-40% of it binds to blood proteins. It ... This lowers the viscosity of the synovial fluid (which increases friction) and causes white blood cells and enzymes to enter ... At 11 times the normal dose, they also had increased alanine transferase, cholesterol, and prothrombin time (i.e. coagulation ...

https://en.wikipedia.org/wiki/Polysulfated_glycosaminoglycan

One is von Willebrand factor (vWF), a multimeric protein that plays a major role in blood coagulation. Storage of long polymers ... white blood cells), allowing them to exit the blood vessel (extravasate) and enter the surrounding tissue, where they can ... Blood. 73 (5): 1109-12. doi:10.1182/blood.V73.5.1109.1109. PMID 2467701. McEver RP, Beckstead JH, Moore KL, Marshall-Carlson L ... Blood. 118 (15): 4265-73. doi:10.1182/blood-2010-11-321489. PMID 21803846. Valentijn KM, Sadler JE, Valentijn JA, Voorberg J, ...

https://en.wikipedia.org/wiki/Weibel–Palade_body

Blood coagulation factors[edit]. *Coagulation factor VIIIα. *Coagulation factor IXα ... Blood products of human origin and plasma substitutes[edit]. Blood and blood components[edit]. ... 11 Blood products of human origin and plasma substitutes *11.1 Blood and blood components ...

https://en.wikipedia.org/wiki/List_of_World_Health_Organization_Essential_Medicines

Among other things, he investigated the action of the venom of this snake on fibrinolysis and blood coagulation. Among his many ... The substance, a short kinin with nine amino acids only, was detected in the blood plasma of dogs after the addition of venom ... May-Grunwald-Giemsa blood staining technique video Kelen EM, Rosenfeld G, Vainzof M, & Machado ZC. Experimental defibrination ... Maurício Rocha e Silva and Wilson Teixeira Beraldo, a new endogenous peptide capable of causing a powerful fall of blood ...

https://en.wikipedia.org/wiki/Gastão_Rosenfeld

Once a successful biologist employed by Biosyn, he lost credibility when his research on blood-coagulation factors failed. ... Later in the film, Wu plans to get blood from Blue the Velociraptor to make an improved Indoraptor. However, he is told by ... As Hamada picks it up, he notices blood dripping from above and realizes the beast can disguise itself with camouflage. The ... After Blue is shot, she operates on the Velociraptor and saves Blue's life with a transfusion of Tyrannosaurus blood. Zia and ...

https://en.wikipedia.org/wiki/List_of_Jurassic_Park_characters

Joseph Lister studied the cause of blood coagulation and inflammation that resulted after previous injuries and surgical wounds ... In 1920, August Krogh won the Nobel Prize for discovering how, in capillaries, blood flow is regulated. In 1954, Andrew Huxley ... Bibcode:2000esrc.book.....A. Rampling, M. W. (2016). "The history of the theory of the circulation of the blood". Clinical ... Each substance is known for having a corresponding humour: black bile, phlegm, blood and yellow bile, respectively. Hippocrates ...

https://en.wikipedia.org/wiki/Physiology

Mans BJ, Louw AI, Neitz AW (October 2002). "Evolution of hematophagy in ticks: common origins for blood coagulation and ... It extracts blood by cutting a hole in the host's epidermis, into which it inserts its hypostome and prevents the blood from ... Newly hatched larvae attach to a host in order to obtain a blood meal. They remain on the host then develop into nymphs. Once ... Female adults then engorge on blood and prepare to drop off to lay her eggs on the ground, while males feed very little and ...

https://en.wikipedia.org/wiki/Tick

His dissertation work involved synthesis of heparinized block copolymers and analysis of their blood coagulation properties in ... early research focused on the failure of medical implants in the human body and the problems associated with blood coagulation ...

https://en.wikipedia.org/wiki/David_W._Grainger

... and abnormalities in blood clotting often consistent with disseminated intravascular coagulation (DIC) such as a prolonged ... This may cause vomiting blood, coughing up of blood, or blood in stool.[32] Bleeding into the skin may create petechiae, ... Blood products such as packed red blood cells, platelets, or fresh frozen plasma may also be used.[135] Other regulators of ... an initially decreased white blood cell count followed by an increased white blood cell count; elevated levels of the liver ...

https://en.m.wikipedia.org/wiki/Ebola_virus_disease

... ductus arteriosus blood vessel.[47][150] Prolonged use of salicylic acid over significant areas of the skin or under occlusive ...

https://en.wikipedia.org/wiki/Acne_vulgaris

Pages in category "Blood proteins". The following 39 pages are in this category, out of 39 total. This list may not reflect ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Category:Blood_proteins&oldid=804272786" ...

https://en.wikipedia.org/wiki/Category:Blood_proteins

Cord blood has a higher concentration of HSC than is normally found in adult blood. However, the small quantity of blood ... Coagulation issues and inflammation of atherosclerotic plaques are known to occur as a result of G-CSF injection. G-CSF has ... Umbilical cord blood[edit]. Umbilical cord blood is obtained when a mother donates her infant's umbilical cord and placenta ... Allogeneic cord blood is stored frozen at a cord blood bank because it is only obtainable at the time of childbirth. To ...

https://en.wikipedia.org/wiki/Bone_Marrow_Transplant

positive regulation of coagulation. • negative regulation of apoptotic signaling pathway. • neuron development. • memory. • ... blood vessel development. • membrane protein ectodomain proteolysis. • regulation of epidermal growth factor-activated receptor ...

https://en.wikipedia.org/wiki/PSEN1

McMullen BA, Fujikawa K, Kisiel W, et al. (1983). „Complete amino acid sequence of the light chain of human blood coagulation ... Hassan HJ, Leonardi A, Chelucci C, et al. (1990). „Blood coagulation factors in human embryonic-fetal development: preferential ... Leytus SP, Foster DC, Kurachi K, Davie EW (1986). „Gene for human factor X: a blood coagulation factor whose gene organization ... Fung MR, Hay CW, MacGillivray RT (1985). „Characterization of an almost full-length cDNA coding for human blood coagulation ...

https://hu.wikipedia.org/wiki/Stuart–Prower-faktor

t-PA is released into the blood very slowly by the damaged endothelium of the blood vessels, such that, after several days ( ... Coagulation inhibitors. *Antithrombin (inhibits II, IX, X, XI, XII). *Protein C (inhibits V, VIII)/Protein S (cofactor for ... In fibrinolysis, a fibrin clot, the product of coagulation, is broken down.[2] Its main enzyme plasmin cuts the fibrin mesh at ... Fibrinolysis is a process that prevents blood clots from growing and becoming problematic.[1] This process has two types: ...

https://en.wikipedia.org/wiki/Fibrinolysis

It is the blood plasma without the fibrinogens. Serum includes all proteins not used in blood clotting (coagulation) and all ... Anti-coagulated blood yields plasma containing fibrinogen and clotting factors. Coagulated blood (clotted blood) yields serum ... Serum is a clear, yellowish coloured fluid which is part of the blood.[1] It does not contain white or red blood cells or a ... "blood serum or serum". Collins Dictionary of Biology. 2005. Retrieved 16 June 2012.. ...

https://simple.wikipedia.org/wiki/Serum_

... tumours that block or hoard blood supply, and disseminated intravascular coagulation or other thromboses. ... This is due to the lysis of neutrophils, a type of white blood cell, caused by the lecithinases and other toxins released by ... compare to 4-5 kPa in venous blood under normal conditions, with 11-13 kPa in arteries and 21 kPa in air at sea level), so if ...

https://en.m.wikipedia.org/wiki/Myonecrosis

APS provokes blood clots (thrombosis) in both arteries and veins as well as pregnancy-related complications such as miscarriage ... Thus, anti-annexin A5 antibodies increase phospholipid-dependent coagulation steps.[8] The Lupus anticoagulant antibodies are ... Kay Thackray (2003). Sticky Blood Explained. Braiswick. ISBN 978-1-898030-77-5.. A personal account of dealing with the ... Antiphospholipid syndrome can cause arterial or venous blood clots, in any organ system, or pregnancy-related complications. In ...

https://en.wikipedia.org/wiki/Antiphospholipid_syndrome

A quick anti-Xa-activity-based whole blood coagulation assay for monitoring unfractionated heparin during cardiopulmonary ... Effects of heparin on polymerase chain reaction for blood white cells»։ J. Clin. Lab. Anal. 13 (3): 133-40։ 1999։ PMID 10323479 ... Higgins, C. (October 2007)։ «The use of heparin in preparing samples for blood-gas analysis»։ Medical Laboratory Observer ... CBS News, Blood-thinning drug under suspicion Archived 2012-10-23 at the Wayback Machine. ...

https://hy.wikipedia.org/wiki/Հեպարին

The gut mucosal cells do not get enough nourishment from arterial blood supply to stay healthy, especially in very premature ... Additional laboratory changes (metabolic and respiratory acidosis, disseminated intravascular coagulation). More recently, ... The underlying mechanism is believed to involve a combination of poor blood flow and infection of the intestines.[2] Diagnosis ... blood in the stool, or vomiting of bile.[1][2] ... infants, where the blood supply is limited due to immature ...

https://en.wikipedia.org/wiki/Necrotizing_enterocolitis

A scanning electron microscope image of normal circulating human blood. One can see red blood cells, several knobby white blood ... The coagulation system overlaps with the immune system. Some products of the coagulation system can contribute to the non- ... Identification and removal of foreign substances present in organs, tissues, blood and lymph, by specialized white blood cells ... All white blood cells (WBCs) are known as leukocytes. Most leukocytes differ from other cells of the body in that they are not ...

https://en.wikipedia.org/wiki/Innate_immune_system

Roles of platelets and factor XI in the initiation of blood coagulation by thrombin. Thromb. Haemost.. July 2001, roč. 86, čís ... Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with ...

https://cs.wikipedia.org/wiki/Faktor_XI

Blood. 82 (5): 1532-7. PMID 8395910. "Entrez Gene: F2R coagulation factor II (thrombin) receptor". "José RJ, Williams AE, ... blood. 105 (8): 3178-84. doi:10.1182/blood-2004-10-3985. PMID 15626732. José RJ, Williams AE, Mercer PF, Sulikowski MG, Brown ... PAR-1 has multifaceted effects and plays a key role in mediating the interplay between coagulation and inflammation, which is ... Hoffman M, Church FC (Aug 1993). "Response of blood leukocytes to thrombin receptor peptides". Journal of Leukocyte Biology. 54 ...

https://en.wikipedia.org/wiki/Coagulation_factor_II_receptor

blood coagulation. • positive regulation of Arp2/3 complex-mediated actin nucleation. • actin filament-based movement. • ... 97 (9): 2633-9. doi:10.1182/blood.v97.9.2633. PMID 11313252.. *^ a b She HY, Rockow S, Tang J, Nishimura R, Skolnik EY, Chen M ...

https://en.wikipedia.org/wiki/Wiskott-Aldrich_syndrome_protein

Bipolar coagulation[edit]. This method uses electric current to cauterize sections of the fallopian tube, with or without ... Major complications from laparoscopic surgery may include need for blood transfusion, infection, conversion to open surgery, or ... Monopolar coagulation[edit]. This method uses electric current to cauterize the tube, but also allows radiating current to ... further damage the tubes as it spreads from the coagulation site. The tubes may also be transected after cauterization.[24] The ...

https://en.wikipedia.org/wiki/Tubal_ligation

... a condition of blood clotting in the blood vessels), coining the terms embolism and thrombosis.[56] He noted that blood clots ... claim made by the eminent French pathologist Jean Cruveilhier that phlebitis led to clot development and therefore coagulation ... He found an unusual number of white blood cells, and gave a detailed description in 1847 and named the condition as leukämie.[ ... Virchow correctly identified the condition as a blood disease, and named it leukämie in 1847 (later anglicised to leukemia).[34 ...

https://en.m.wikipedia.org/wiki/Rudolf_Virchow

... which draws large numbers of white blood cells to the area and increases the regional blood flow. ...

https://en.wikipedia.org/wiki/Abscess

Affecting blood pressure/(antihypertensive drugs): ACE inhibitors, angiotensin receptor blockers, beta-blockers, α blockers, ... Coagulation: anticoagulants, heparin, antiplatelet drugs, fibrinolytics, anti-hemophilic factors, haemostatic drugs. *HMG-CoA ... There are many variations in the routes of administration, including intravenous (into the blood through a vein) and oral ... There are three major categories of drug administration; enteral (by mouth), parenteral (into the blood stream), and other ( ...

https://en.m.wikipedia.org/wiki/Pharmaceutical

A coagulation, also known as clot is a semi-solid substance that blood forms, especially when it is in air. When a person ... Proteins in the blood plasma, called coagulation factors or clotting factors, respond in a complex cascade to form fibrin ... Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium lining the vessel. When ... A blood clot is also called a thrombus. The process is called coagulation. ...

https://simple.wikipedia.org/wiki/Coagulation

"Biochemistry and physiology of blood coagulation". Thromb. Haemost. 82 (2): 165-74. பப்மெட்:10605701. http://www.schattauer.de/ ... "Blood 93 (6): 1798-808. பப்மெட்:10068650. http://bloodjournal.hematologylibrary.org/cgi/content/full/93/6/1798. ...

https://ta.wikipedia.org/wiki/உயிர்ச்சத்து_கே

Routine blood tests (complete blood count, electrolytes, renal function, liver enzymes) are typically performed. Mast cell ... Additionally, it inhibits various proteins of the coagulation cascade, although effects of its deficiency on the development of ... Abdominal attacks have also been known to cause a significant increase in the patient's white blood cell count, usually in the ... In an emergency, fresh frozen blood plasma, which also contains C1-INH, can also be used. However, in most European countries, ...

https://en.wikipedia.org/wiki/Angioneurotic_oedema

... including disseminated intravascular coagulation (DIC), cellular necrosis (tissue death), low blood pressure, gangrene, and ... separation and removal of blood plasma from blood cells) and/or leukapheresis (removal of excess white blood cells) are often ... The bacteria cultures well on blood agar plates (heart infusion agar with 5% sheep or rabbit blood) and chocolate agar plates. ... In incidents where the patient is in full septic shock, whole blood smears may be effective. Immediate cleansing of wounds ...

https://en.wikipedia.org/wiki/Capnocytophaga_canimorsus

blood coagulation. • proteolysis. • ER to Golgi vesicle-mediated transport. • blood coagulation, extrinsic pathway. ... Leytus SP, Foster DC, Kurachi K, Davie EW (September 1986). "Gene for human factor X: a blood coagulation factor whose gene ... Blood coagulation pathways in vivo showing the central role played by thrombin ... Kaul RK, Hildebrand B, Roberts S, Jagadeeswaran P (1986). "Isolation and characterization of human blood-coagulation factor X ...

https://en.wikipedia.org/wiki/Factor_X

The Indians hold this bark in high regard, and use it for all sorts of diarrhea, that are with blood [i.e., bloody] and without ... disseminated intravascular coagulation, leukopenia, and neutropenia. Some people who have developed TTP due to quinine have ... Blood glucose, electrolyte and cardiac monitoring are not necessary when quinine is given by mouth. ... Quinine can cause unpredictable serious and life-threatening blood and cardiovascular reactions including low platelet count ...

https://en.wikipedia.org/wiki/Quinine

... mainly due to vasodilation of the peripheral small blood vessels), swelling of the conjunctiva, itching, and increased ...

https://en.wikipedia.org/wiki/Pink_Eye

Because the reaction is slow, the Hb A1c proportion represents glucose level in blood averaged over the half-life of red blood ... Increased levels of this chemical are detected in the blood if red blood cells are being destroyed more rapidly than usual. ... Hemoglobin concentration measurement is among the most commonly performed blood tests, usually as part of a complete blood ... It measures the degree of glycation (glucose binding) to albumin, the most common blood protein, and reflects average blood ...

https://en.wikipedia.org/wiki/Hemoglobin_deficiency

Several microangiopathic diseases, including disseminated intravascular coagulation and thrombotic microangiopathies, present ... Several blood tests involve red blood cells. These include a RBC count (the number of red blood cells per volume of blood), ... Main article: Blood transfusion. Red blood cells may be given as part of a blood transfusion. Blood may be donated from another ... Packed red blood cells (pRBC) are red blood cells that have been donated, processed, and stored in a blood bank for blood ...

https://en.m.wikipedia.org/wiki/Red_blood_cells

Another toxin is phallolysin, which has shown some hemolytic (red blood cell-destroying) activity in vitro. An unrelated ... and impaired coagulation.[74] ... accumulation of normally liver-removed substance in the blood.[ ...

https://en.m.wikipedia.org/wiki/Amanita_phalloides

Mathematical model of blood coagulation and the effects of inhibitors of Xa, Va:Xa and IIa. ... SBML L2V4 representation of Nagashima2002 - Simulating blood coagulation inhibitory effects. 58.52 KB. Preview , Download. ... and thrombin affect extrinsic pathway-triggered blood coagulation. Numerical simulation demonstrated a stronger inhibition of ... thrombin generation by fXa and thrombin inhibitors and has implications for the pharmacological regulation of blood coagulation ...

http://www.ebi.ac.uk/biomodels/MODEL1807230003

... it immediately contracts to limit the flow of blood. Within a few seconds cell-like blood platelets (about 1/8 the diameter of ... E. W. Davie, K. Fujikawa, M. E. Legaz and H. Kato, "Role of Proteases in Blood Coagulation," in Proteases and Biological ... Elliott D.L. (1978) Mathematical Models of Blood Coagulation Kinetics. In: Mohler R.R., Ruberti A. (eds) Recent Developments in ... If a mammalian blood vessel is severed, it immediately contracts to limit the flow of blood. Within a few seconds cell-like ...

https://link.springer.com/chapter/10.1007/978-3-642-45509-4_7

Today marks the third lustrum of the annual international sympo- sium on blood transfus ... Coagulation and Blood Transfusion. Proceedings of the Fifteenth Annual Symposium on Blood Transfusion, Groningen 1990, ... Structural and Functional Properties of Recombinant Coagulation Factors A. Pavirani, S. Krishnan, S. Jallat, F. Perraud, A. ... Today marks the third lustrum of the annual international sympo- sium on blood transfusion, organized by the Rode Kruis ...

https://link.springer.com/book/10.1007%2F978-1-4615-3900-1

New subscriptions to Blood Coagulation & Fibrinolysis are managed through Lippincott Williams & Wilkins (LWW) online store. If ... Subscription renewals for Blood Coagulation & Fibrinolysis are managed through Lippincott Williams & Wilkins online store. If ...

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A Laboratory Manual of Blood Coagulation Br Med J 1977; 1 :392 ... A Laboratory Manual of Blood Coagulation. Br Med J 1977; 1 doi ...

https://www.bmj.com/content/1/6057/392.3/submit-a-rapid-response

Coagulation Sample Collection for Coagulation Testing 1. Collection Tube. Blood should be collected in a blue-top tube ... Blood Specimens: Coagulation Blood Specimens: Coagulation. Sample Collection for Coagulation Testing. 1. Collection Tube. Blood ... Collection of blood for coagulation testing through intravenous lines that have been previously flushed with heparin should be ... Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays; Approved Guideline-Fifth ...

https://www.labcorp.com/resource/blood-specimens-coagulation

Blood coagulation is a basic physiological defense mechanism that occurs in all vertebrates to prevent blood loss following ... Blood coagulation is a basic physiological defense mechanism that occurs in all vertebrates to prevent blood loss following ... Comparative aspects of blood coagulation Vet J. 2004 Nov;168(3):238-51. doi: 10.1016/j.tvjl.2003.09.013. ... Thrombin converts soluble fibrinogen, via soluble fibrin monomers, into the insoluble fibrin that forms the matrix of a blood ...

https://pubmed.ncbi.nlm.nih.gov/15501141/?dopt=Abstract

6. Apparatus for testing blood coagulation comprising in combination: (a) a container for holding a blood sample; (b) an ... Method for measuring blood coagulation and device therefor. US4398894 *. Jun 8, 1981. Aug 16, 1983. Kabushiki Kaisha Kyoto ... A source of EMF 28 is connected between the two electrodes and the circuit is completed when a wet mass of blood coagulation ... The thread is of a material to which blood coagulation substances adhere, preferably a water wettable material such as glass, ...

http://www.google.com/patents/US3814585?dq=7,177,838

... pathway of blood coagulation is associated with increased blood thrombogenicity and increases in markers of blood coagulation ... blood coagulation. Summary. Summary: The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble ... blood coagulation tests*hemostasis*hemorrhage*blood coagulation factors*anticoagulants*thrombin*thromboplastin* ... the blood-clotting assay is prudent to ensure dengue protease inhibitors do not interfere with the blood coagulation cascade ( ...

https://www.labome.org/topics/physical/natural/biological/circulatory/blood/blood/hemostasis/blood-coagulation-19993.html

SEARCH RESULTS for: Blood Coagulation Factor [Drug Class] (630 results) *Share : JavaScript needed for Sharing tools. Bookmark ... ALPHANINE SD (coagulation factor ix (human)) kit. NDC Code(s): 63323-185-10, 68516-1002-2, 68516-3601-2, 68516-3602-2, view ...

https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Blood%20Coagulation%20Factor&searchdb=class

Current aspects of blood coagulation, fibrinolysis, and platelets. [M -C Shen; C -M Teng; Akikazu Takada;] ... coagulation_disorders> # Blood Coagulation Disorders. a schema:Intangible ;. schema:name "Blood Coagulation Disorders"@en ;. . ... coagulation_congresses> # Blood--Coagulation--Congresses. a schema:Intangible ;. schema:name "Blood--Coagulation--Congresses"@ ... schema:name "Blood Coagulation"@en ;. schema:name "Blood--Coagulation"@en ;. ..

http://www.worldcat.org/title/current-aspects-of-blood-coagulation-fibrinolysis-and-platelets/oclc/28224618

Blood Coagulation and it Biochemistry and Molecular Biology. Our laboratory has focused on understanding the metal- and ... Airway, Breathing & Lung Allergies & Immune System Bone, Joint & Muscle Brain, Spine & Nervous System Cancers, Tumors & Blood ... remain major areas of interest to understand protein complex formation on membrane surfaces during blood coagulation. ... Center Balloon Weight Loss Program Benign Hematology Program Beth Israel Deaconess HealthCare Biologic Therapy Program Blood ...

https://www.bidmc.org/research/research-by-department/medicine/hemostasis-and-thrombosis/biochemistry-and-molecular-biology-of-blood-coagulation

Diseases : Blood Coagulation Disorders, Drug-Induced Toxicity , Fibrinogen: Elevated, Hypothyroidism. Problem Substances : ... Diseases : Blood Coagulation Disorders, Clotting, Hypertension. Therapeutic Actions : Dietary Modification: Mediterranean Diet ... 8 Abstracts with Blood Coagulation Disorders Research. Filter by Study Type. Human Study. ... 2 Problem Substances Researched for Blood Coagulation Disorders Name. AC. CK. Focus. ...

https://www.greenmedinfo.com/disease/blood-coagulation-disorders

1634 Studies found for: Blood Coagulation Disorders: Clinical Trials. Also searched for Hemostatic disorder, Diseases, Trials ... Units of blood products used (red blood cells, plasma, platelets, prothrombin complex concentrate, fibrinogen, Factor VIIa, ... Blood product transfusion. 100. All. 18 Years and older (Adult, Senior). NCT02557672. 14-009579. August 2016. July 2018. July ... Number of blood products transfused. 82. All. 12 Years and older (Child, Adult, Senior). NCT02132208. CHRcitadelle-trauma-01. ...

https://clinicaltrials.gov/ct2/results?term=Blood+Coagulation+Disorders%3A+Clinical+Trials

Coagulation Factor IX Human. Coagulation factor X. target. DB13152. Coagulation Factor IX Human. Coagulation factor XI. target ... Coagulation factor VII human. Coagulation factor X. target. DB13150. Coagulation factor VII human. Coagulation factor IX. ... Coagulation Factor IX Human. Coagulation factor VII. target. DB13152. Coagulation Factor IX Human. Coagulation factor VIII. ... Coagulation Factor IX (Recombinant). Coagulation factor X. target. DB00100. Coagulation

https://www.drugbank.ca/categories/DBCAT000075

Phys.org) -Stanching the free flow of blood from an injury remains a holy grail of clinical medicine. Controlling blood flow is ... As serine proteases play pivotal roles in blood coagulation, the innate immune system ... ... PhysOrg.com) -- Some things are more fun to learn than others, and the coagulation cascade has traditionally been ranked among ... Bio-inspired bleeding control: Researchers synthesize platelet-like nanoparticles that can do more than clot blood. ( ...

https://phys.org/tags/blood+coagulation/

Coagulation tests in 28 patients detected thrombocytopenia in 17, hypofibrinogenemia in ni … ... Patients with typhoid fever were studied to determine whether disseminated intravascular coagulation (DIC), circulating ... Studies of blood coagulation, bacteremia, and endotoxemia Arch Intern Med. 1978 Mar;138(3):407-10. doi: 10.1001/archinte.138.3. ... Coagulation tests in 28 patients detected thrombocytopenia in 17, hypofibrinogenemia in nine, and elevated titers of fibrinogen ...

https://pubmed.ncbi.nlm.nih.gov/629635/

Miscarriages Caused by Blood Coagulation Protein or Platelet Deficits * Sections Miscarriages Caused by Blood Coagulation ... Miscarriages Caused by Blood Coagulation Protein or Platelet Deficits) and Miscarriages Caused by Blood Coagulation Protein or ... Miscarriages Caused by Blood Coagulation Protein or Platelet Deficits. Updated: Dec 21, 2018 ... Bick RL, Hoppensteadt D. Recurrent miscarriage syndrome and infertility due to blood coagulation protein/platelet defects: a ...

https://emedicine.medscape.com/article/210857-overview

... allowing them to see results from their at-home blood clotting tests on an iOS device. ... The app connects via Bluetooth to the CoaguChek XS meter, which patients use to test PT/INR, the time it takes for blood to ... Roche unveiled a new app for patients on anticoagulation therapy, allowing them to see results from their at-home blood ... Earlier this year, Roche launched the CoaguChek INRange system in Europe, which helps patients and doctors monitor coagulation ...

https://www.fiercebiotech.com/medical-devices/roche-debuts-ios-app-for-blood-coagulation-test-device

Blood coagulation is viewed as a process resulting in fibrin polymerization, which is considered as the first step towards ... In this work a mathematical model for blood coagulation induced by an activator source is presented. ... In this work a mathematical model for blood coagulation induced by an activator source is presented. Blood coagulation is ... A mathematical model of blood coagulation induced by activation sources. Georgy Th. Guria 1, , Miguel A. Herrero 2, and Ksenia ...

http://www.aimsciences.org/journals/displayArticles.jsp?paperID=4275

Young, COVID = Pathological Blood Coagulation. As I have previously stated, when it comes to COVID, there is not 1 virus, not 1 ... circulatory problems that stem from pathological blood coagulation. In technical medical terms, this coagulation (lumping and ... People suffering from this kind of pathological blood coagulation will experience oxygen deprivation (hypoxia or under ... the blood changes from a liquid to a gel or semi-solid state, forming a blood clot... ...

https://bibliotecapleyades.net/ciencia3/ciencia_coronavirus115.htm

Essential Guide to Blood Coagulation has been updated to include the new anticoagulants and now has a dedicated chapter on ... Essential Guide to Blood Coagulation covers both the stable and the acute stages of hereditary and acquired bleeding and ... Essential Guide to Blood Coagulation, 2nd Edition. Jovan P. Antovic (Editor) , Margareta Blombäck (Editor) ... 16 Emergency conditions associated with coagulation: DIC, HIT and TTP/HUS, 182. Jovan P. Antovic and Margareta Holmström ...

https://www.wiley.com/en-us/Essential+Guide+to+Blood+Coagulation%2C+2nd+Edition-p-9781118327517

Blood coagulation in anhepatic pigs: effects of treatment with the AMC-bioartificial liver.. Sosef MN1, Van De Kerkhove MP, ... The aim of this study was to assess the contribution of BAL treatment on blood coagulation parameters. Pigs were anesthetized ... Coagulation parameters studied concerned prothrombin time (PT), platelet count, the procoagulant system (factors (F)II, FV, ... This demonstrates that this bioartificial liver is capable of synthesizing coagulation factors. ...

https://www.ncbi.nlm.nih.gov/pubmed/12871459

To allow blood coagulation, in humans there exist 13 blood clotting proteins, called coagulation factors, which are usually ... A Mechanistic Model of the Blood Coagulation Cascade. Blood is an essential component in human life, whose primary functions ... Graphical representation of the blood coagulation cascade model considered in this work. Legend. Blue box: coagulation factor; ... Since the aim of this work is the investigation of blood coagulation in vivo, we exclude a small set of reactions given in [30 ...

https://www.hindawi.com/journals/bmri/2014/863298/

... blood coagulation include Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes, A Microfluidic Flow ... Repeated Blood Collection for Blood Tests in Adult Zebrafish, Proliferation and Differentiation of Murine Myeloid Precursor ... Blood Collection for Biochemical Analysis in Adult Zebrafish, Procedure for Decellularization of Rat Livers in an Oscillating ... Evaluation of Blood Lactate and Plasma Insulin During High-Intensity Exercise by Antecubital Vein Catheterization, Direct ...

https://www.jove.com/keyword/blood+coagulation

Parallel Studies of Complement and Blood Coagulation. VII. The Effect of Ethionine. Christine E. Rice, Paul Boulanger, P. J. G ... Parallel Studies of Complement and Blood Coagulation Message Subject (Your Name) has forwarded a page to you from The Journal ... 3. A moderate to marked prolongation of the coagulation time of the plasma was recorded in guinea pigs that had received ...

https://www.jimmunol.org/content/68/6/673

... with modulatory effects or modulated by the coagulation cascade have been reported to affect the pathophysiology of the central ... being able to interfere with synaptic homeostasis other than coagulation itself. These specific functions modulate neuronal ... Blood coagulation factors and other proteins, with modulatory effects or modulated by the coagulation cascade have been ... "Neuro-Coagulopathy: Blood Coagulation Factors in Central Nervous System Diseases." Int. J. Mol. Sci. 18, no. 10: 2128. ...

http://www.mdpi.com/1422-0067/18/10/2128

Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo, Surface Engineering of Pancreatic Islets ... Video articles in JoVE about blood coagulation factors include An In Vitro Model of a Parallel-Plate Perfusion System to Study ... Blood Coagulation Factors: Endogenous substances, usually proteins, that are involved in the blood coagulation process. . ... Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo. Tim R. Glowka1, Pascal Paschenda2, Michael ...

https://www.jove.com/search?q=blood%20coagulation%20factors&page=6

Pericardial Blood Activates the Extrinsic Coagulation Pathway During Clinical Cardiopulmonary Bypass. Judith H. Chung, Nicolas ... Pericardial Blood Activates the Extrinsic Coagulation Pathway During Clinical Cardiopulmonary Bypass. Judith H. Chung, Nicolas ... Pericardial Blood Activates the Extrinsic Coagulation Pathway During Clinical Cardiopulmonary Bypass. Judith H. Chung, Nicolas ... Thrombogenic mechanisms in the human: fresh insights obtained by immunodiagnostic studies of coagulation markers. Blood Coagul ...

http://circ.ahajournals.org/content/93/11/2014.full

New subscriptions to Blood Coagulation & Fibrinolysis are managed through Lippincott Williams & Wilkins (LWW) online store. (lww.com)
Subscription renewals for Blood Coagulation & Fibrinolysis are managed through Lippincott Williams & Wilkins online store. (lww.com)
The first Sino-Japanese symposium on Coagulation, Fibrinolysis and Platelets, originating from the Hamamatsu symposium, held in early 1990, was held in Hanchow, Mainland China in October, 1990. (worldcat.org)
The dysfunction of the blood coagulation-fibrinolysis system is a salient characteristic of PE that varies in severity, and necessitates different treatments. (plos.org)
They active other coagulation factors within the body and these help to arrest clotting, resulting in fibrinolysis(Brand,1985). (ukessays.com)
Changes in platelet function, blood coagulation and fibrinolysis during insulin-induced hypoglycaemia in juvenile diabetics and normal subjects. (nih.gov)
FIELD OF THE INVENTION This invention relates to detecting changes in viscosity of biologic fluid test samples, e.g., detecting coagulation and coagulation-related activities including agglutination and fibrinolysis of human blood test samples, and more particularly to improved methods and apparatus for obtaining a coagulation time of a blood test sample. (google.com)
There are surprisingly few interventional studies to assess the true effects of estrogen-progestin regimens on blood coagulation and fibrinolysis, and the impact of the route of estrogen administration on hemostasis has not been well documented. (ahajournals.org)
Blood coagulation and fibrinolysis of the newborn viewed äs perinatal factors. (hu-berlin.de)
Alterations of fibrinolysis and blood coagulation induced by exercise, and the role of beta-adrenergic receptor-stimulation. (springer.com)

Within a few seconds cell-like blood platelets (about 1/8 the diameter of a red cell) touch the cut edges, break down, and aggregate into a plug-like mass. (springer.com)
Fibrin sticks at the site of cut with platelets to make stable blood clot. (ukessays.com)
Exposure of the blood to proteins such as tissue factor starts changes to blood platelets and the plasma protein fibrinogen, a clotting component. (omicsonline.org)
Although it behaves like a homogeneous fluid in large vessels such as arteries, human blood is really a suspension of solids (blood cells, platelets) that can alter their characteristics in response to chemical and physical provocation. (bcr.org)
The process begins when blood-clotting proteins bind to the membranes of activated platelets. (bcr.org)
There is ongoing debate whether an increase in the number of blood cells (especially platelets) is solely responsible for thrombotic complications observed in the course of this disease [ 4 , 5 ]. (mdpi.com)
The results showed that Cd intoxication impaired hepatorenal function and significantly prolonged prothrombin time and activated partial thromboplastin time and decreased fibrinogen level, red blood cells and platelets counts, hemoglobin concentration, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration. (hindawi.com)
Fibrin are long strands of protein which then form a mesh network securing the platelets laid down in the previous phases of hemostasis and trapping other blood cells and components to form a blood clot . (healthhype.com)
The reason for the thrombosis could be excessive activation of the coagulation factors and platelets. (thieme.com)
According to Prof. Violi, these "reactive oxygen species" not only activate blood clotting and platelets but also cause the blood vessels to constrict (vasoconstriction). (thieme.com)
The values for coagulation indices, clotting time, and Russel viper venom time were consistent with decreased thrombotic tendency of platelets from animals on the SSO diet relative to the low fat, REF diet animals, while an increased tendency to thrombosis was observed with SF-fed marmosets. (ahajournals.org)
In this paper, we describe how the circulating blood cells - monocytes, platelets, neutrophils and their microparticles - co-operate in regulating the expression, availability and activity of monocyte-derived TF. (biochemsoctrans.org)
The reason why this is so hinges on the several thrombin-dependent positive feedback reactions of the coagulation cascade, including the activation of FVIII and FV in addition to the potent activation of platelets. (biochemsoctrans.org)
Conclusions In this population-based cohort, we found associations of long-term exposure to PM with markers of inflammation (hs-CRP) and coagulation (platelets). (bmj.com)
Independent of adding exogenous tissue factor (TF), human blood treated in vitro with corn trypsin inhibitor (CTI, to block Factor XIIa) will generate thrombin after an initiation time ( T i ) of 1 to 2 hours (depending on donor), while activation of platelets with the GPVI-activator convulxin reduces T i to ~20 minutes. (pubmedcentralcanada.ca)
Next, we showed that "contact activation," despite use of the best available inhibitor (CTI) to prevent it, builds up enough autocatalytic strength to trigger coagulation without exogenous TF, particularly upon activated platelets. (pubmedcentralcanada.ca)
2016 -06-09 Hysteresis-like binding of coagulation factors x/xa to procoagulant activated platelets and phospholipids results from multistep association and membrane-dependent multimerization (Podoplelova et al. (vcell.org)
In contrast, regular exercise causes decreased activity of platelets and the coagulation system resulting in an improvement in haemostatic balance. (springer.com)

Bovine thrombin is a topical thrombin indicated to aid hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques (like suture, ligature, or cautery) is ineffective or impractical [FDA Label]. (drugbank.ca)
Blood Coagulation Testing is a method used for diagnostics of the hemostasis system. (sbwire.com)
Blood coagulation is an essential part of hemostasis, the discontinuance of blood loss from a damaged vessel, wherein a damaged blood vessel wall is secured by a platelet and fibrin-containing clot to quit bleeding and start repair of the damaged vessel. (omicsonline.org)
Hemostasis is the mechanism to prevent blood loss. (healthhype.com)
There are four main phases to hemostasis with the blood coagulation phase following vascular constriction (first phase) and then the platelet plug (second phase). (healthhype.com)
We developed hepatocyte crush method: (HeCM) using a monopolar soft-coagulation devices for not only hemostasis, but also detachment of blood vessels. (sages.org)
Besides the plasma coagulation factors, undisturbed hemostasis is dependent on thrombocytes and their normal functions. (dtic.mil)
We conclude that oral estrogen/progesterone replacement therapy may result in coagulation activation and increased fibrinolytic potential, whereas opposed transdermal estrogen appears without any substantial effects on hemostasis. (ahajournals.org)
STUDY SELECTION: Articles were selected that provided data on the effects of colloids on hemostasis and postoperative blood loss in humans. (pptaglobal.org)
In general, the aim of the third step of Hemostasis, Blood Coagulation (secondary hemostasis), is what? (brainscape.com)
Clinical standards for patient blood management and perioperative hemostasis and coagulation management. (minervamedica.it)
Patient blood management is currently defined as the application of evidence based medical and surgical concepts designed to maintain hemoglobin (Hb), optimize hemostasis and minimize blood loss to improve patient outcome. (minervamedica.it)
Cinnella G, Pavesi M, De Gasperi A, Ranucci M, Mirabella L. Clinical standards for patient blood management and perioperative hemostasis and coagulation management. (minervamedica.it)

Thrombin converts soluble fibrinogen, via soluble fibrin monomers, into the insoluble fibrin that forms the matrix of a blood clot as well as exerting positive-feedback regulation that effectively promotes additional thrombin generation that facilitates the rapid development of a thrombus. (nih.gov)
Levothyroxine replacement therapy increases coagulation (fibrinogen) following initiation of treatment. (greenmedinfo.com)
Coagulation tests in 28 patients detected thrombocytopenia in 17, hypofibrinogenemia in nine, and elevated titers of fibrinogen-related antigens in 20. (nih.gov)
Coagulation parameters studied concerned prothrombin time (PT), platelet count, the procoagulant system (factors (F)II, FV, FVII, FVIII and fibrinogen), anticoagulant system (AT III), fibrinolytic system (t-PA, PAI-1) as well as markers of coagulation factor activation (TAT complexes, prothrombin fragment F1 + 2). (nih.gov)
The optimum pH for this coagulation was determined for 3 of these, and was found in each case to be approximately pH 6.5, the same as that for the action of thrombin on fibrinogen. (rupress.org)
Standard laboratory tests (blood count, international normalized ratio (INR) / prothrombin time (PT), activated partial thromboplastin time (aPTT) fibrinogen concentration (FIB) were routinely available for guiding transfusion of coagulation blood products. (clinicaltrials.gov)
The investigators expect to measure platelet number, blood cells counts, and levels of fibrinogen, thrombin-antithrombin complex, tissue plasminogen activator, plasminogen activator inhibitor, and factor VII of rats that will be exposed to concentrated New York City particles and filtered air for 6 hours. (epa.gov)
As a result, blood coagulation status can be measured by relating the time scale of speckle intensity fluctuations with clinically relevant coagulation metrics including clotting time and fibrinogen content. (osapublishing.org)
Our results report a close correlation between coagulation metrics measured using LSR and conventional coagulation results of activated partial thromboplastin time, prothrombin time and functional fibrinogen levels, creating the unique opportunity to evaluate a patient's coagulation status in real-time at the point of care. (osapublishing.org)
Evidence for disseminated intravascular coagulation was inconclusive due to the presence of normal to elevated fibrinogen levels, relatively low levels of circulating fibrin split products, and the lack of widespread fibrin thrombus deposition. (ajtmh.org)
The coagulation system was evaluated using a routine coagulation function test performed in the hospital laboratory before coronary angiography, and measurements included prothrombin time, international normalized ratio, activated partial thromboplastin time, fibrinogen time, and thrombin time. (ovid.com)
A prolongation of the activated partial thromboplastin time was found after radiation alone, although the fibrinogen concentration, the substrate of the coagulation cascade, was increased as well. (dtic.mil)
Applying mixed regression models, we analysed associations of long-term (mean of 365 days prior to blood draw) particle exposure at each participant's residence with the level of high-sensitivity C reactive protein (hs-CRP), fibrinogen, platelet and white cell count (WCC), adjusting for short-term PM exposure (moving averages of 1-7 days), personal characteristics, season, ambient temperature (1-5 days), ozone and time trend. (bmj.com)
One hour thereafter, levels of melatonin, fibrinogen, and D-dimer as well as activities of coagulation factor VII (FVII:C) and VIII (FVIII:C) were measured in plasma. (uzh.ch)
Based on a 5-yr experience in POC-supported coagulation management in liver transplantation 19 - 20 we developed and implemented an algorithm including POC-supported coagulation management in cardiovascular surgery, based on first-line therapy with specific coagulation factor concentrates, such as fibrinogen concentrate and prothrombin complex concentrate (PCC), combined with point-of-care thromboelastometry and impedance aggregometry. (asahq.org)

RMS due to blood protein or platelet defects may come about through either of two mechanisms: (1) disorders associated with a hemorrhagic tendency or (2) defects associated with a thrombotic tendency. (medscape.com)
Essential Guide to Blood Coagulation covers both the stable and the acute stages of hereditary and acquired bleeding and thrombotic disorders. (wiley.com)
In order to diagnose disorders in these coagulation factors, different biological tests have been developed (prothrombin time, activated partial thromboplastin time, activated cephalin clotting time, etc. (spiedigitallibrary.org)
Coagulation disorders can lead to an increased risk of haemorrhage or thrombosis. (spiedigitallibrary.org)
Hemophilia A, one of the most common genetic bleeding disorders, is caused by various mutations in the blood coagulation factor VIII ( F8 ) gene. (pnas.org)
Coagulopathies are group of bleeding disorders that affect blood clotting process in the body. (ukessays.com)
Coagulation disorders lead to excessive or prolonged bleeding after an injury (Thijs,1993). (ukessays.com)
These tests determine the quantities of coagulation factors, because these disorders are caused when one or more of coagulation factors are increased, low, or absent(Fihn,1995). (ukessays.com)
They are also aid in the diagnosis of bleeding disorders and monitor the patient's blood clot status and effectiveness of anticoagulant therapy (Fihn,1995). (ukessays.com)
Disorders of coagulation can accelerate to an expanded risk of bleeding (hemorrhage) or obstructive clotting (thrombosis). (omicsonline.org)
Journal of Blood Disorders & transfusion publishs the work related all blood coagulation diseases of all major clinical and medical classifications. (omicsonline.org)
Journal of Blood Disorders & transfusion have a world class Editorial Board and maintains its quality publication with support of its editors in Peer review process. (omicsonline.org)
Understanding blood flow and coagulation is crucial to treating blood disorders such as hemophilia and thrombosis, and to dealing with diseases such as AIDS, malaria, and diabetes that have hematologic consequences. (bcr.org)
Essential advisor to Blood Coagulation covers either the good and the intense phases of hereditary and purchased bleeding and thrombotic disorders. (bitmicro.com)
These types of disruption is seen with various blood clotting disorders. (healthhype.com)
The internationally renowned expert has an assumption of why COVID-19 can so often lead to coagulation disorders. (thieme.com)
In addition to Prof. Violi, several other scientists also point to coagulation disorders in their works published in the Thieme medical journal Thrombosis and Haemostasis and recommend appropriate treatment for these patients. (thieme.com)

Under-filling of citrate collection tubes results in an increased anticoagulant-to-blood ratio and can extend clot-based coagulation assays. (labcorp.com)
Lupus anticoagulants (LA) are are nonspecific antibodies that extend clot-based coagulation assays as the result of their interaction with phospholipid in the reaction mixture. (labcorp.com)
Since the time a vessel is allowed to leak or the ease with which it may be pathogenically blocked have a great bearing on the survival of the human organism, coagulation assays, particularly those which deal with the rate of clot formation, are useful in many respects. (google.com)

The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot. (labome.org)
Prothrombin is administered as part of a cocktail containing several coagulation factors. (drugbank.ca)
Treatment of anhepatic pigs with the AMC-BAL based on freshly isolated porcine hepatocytes does not result in an improved coagulation state due to extensive consumption of clotting factors. (nih.gov)
However, increased levels of TAT complexes and prothrombin fragments F1 + 2 during treatment of anhepatic pigs indicate synthesis and direct activation of coagulation factors, leading to thrombin generation. (nih.gov)
This demonstrates that this bioartificial liver is capable of synthesizing coagulation factors. (nih.gov)
Blood coagulation factors and other proteins, with modulatory effects or modulated by the coagulation cascade have been reported to affect the pathophysiology of the central nervous system (CNS). (mdpi.com)
De Luca C, Virtuoso A, Maggio N, Papa M. Neuro-Coagulopathy: Blood Coagulation Factors in Central Nervous System Diseases. (mdpi.com)
The coagulation mechanism implies a complex series of cascading enzymatic reactions involving proteins, referred to as coagulation factors. (spiedigitallibrary.org)
Blood coagulation factors are proteins that released along with blood proteins. (ukessays.com)
Coagulations tests such as ThrombinTime (TT) ,PT (Prothrombin Time) and Activated partial thromboplastin time (APTT) are performed to determine the defects associated with coagulation factors of the coagulation cascade(Fihn,1995). (ukessays.com)
Patient 1 had normal TT, PT and APTT .Patient had adequate levels of coagulation factors in the extrinsic, intrinsic and common pathways. (ukessays.com)
Subject matter wherein the peptide composition is related to fibrinopeptides, blood-coagulation factors or derivative. (patentgenius.com)
To Analyze the Global Blood Coagulation Testing Market based on various factors- price analysis, supply chain analysis, porters five force analysis etc. (sbwire.com)
This study testified that HCT, flow velocity, and tubing size were substantial factors affecting the backscattering properties during flowing blood coagulation. (spiedigitallibrary.org)
The discussions of biochemical principles of fibrin formation (Blomback), interactions of soluble clotting factors (Denson, Hemker, and Hanahan), and the structure of individual clotting factors (Esnouf and Magnusson) are sophisticated considerations of highly specialized subjects of coagulation. (annals.org)
It covers the volumes, prices, historical growth and future perspectives in the Blood Coagulation Analyzer market and further lays out an analysis of the factors influencing the supply/demand for Blood Coagulation Analyzer, and the opportunities/challenges faced by industry participants. (sbwire.com)
The coagulation process involves 12 clotting factors (11 different specialized chemicals and calcium) which act on each other to lead to clot formation and this is known as the coagulation cascade . (healthhype.com)
Extrinsic pathway which is mediated by factors outside of the blood released during injury. (healthhype.com)
Intrinsic pathway which is mediated by factors within the blood coming into contact with the damaged area. (healthhype.com)
The "Coagulation Factors 2009: Target Pipeline and Corporate Benchmark Analysis" report is the most complete and up-to-date evaluation and assessment of the recombinant and plasma-derived coagulation factor pipelines. (pipelinereview.com)
The authors analyze and assess the target pipeline for each of the coagulation factors used for systemic and topical administration. (pipelinereview.com)
Technologies used for creation of next generation coagulation factors are discussed and assessed. (pipelinereview.com)
Replacement of plasma-derived coagulation factors by marketed recombinant molecules is ongoing and will further increase by new recombinant coagulation factors in development. (pipelinereview.com)
Blood coagulation analyzer Worldwide Market Research Report examined the growth rate and the Blood coagulation analyzer Market value based on industry dynamics, growth-driving factors. (einpresswire.com)
Blood coagulation analyzer Market report serves a clear insight about the prominent factors that are witnessed to transform the worldwide market in the upcoming years. (einpresswire.com)
Abnormal coagulation factors in Chinese patients with COVID-19 were associated with poor prognosis (5). (who.int)
RVV came to be useful in laboratory tests for blood clotting factors V, X, prothrombin and phospholipid. (wikipedia.org)
in this study, one would expect the clotting time to be significantly shortened if there was only a deficiency of coagulation factors alone. (wikipedia.org)

All heatstoke animals displayed and activated coagulation evidenced by increased prothrombin time (PT), activated partial thromboplastin time (aPTT), D-dimer, and decreased platelet count, protein C. Furthermore, the animals displayed systemic inflammation evidenced by increased the serum levels of cytokines interleukin-1ß (IL-1ß), tumor necrosis factor α (TNF-α) and malondialdehyde (MDA). (sigmaaldrich.com)

The present study began with mathematical modeling of how inhibitors of both factor Xa (fXa) and thrombin affect extrinsic pathway-triggered blood coagulation. (ebi.ac.uk)
Background Coagulation during cardiopulmonary bypass (CPB) traditionally has been attributed to activation of the contact system of plasma proteins and the intrinsic coagulation pathway by blood contact with negatively charged surfaces not lined by endothelium. (ahajournals.org)
Recent studies have focused on the possible role of the extrinsic coagulation pathway during cardiac surgery. (ahajournals.org)
We postulated that the wound activates the extrinsic coagulation pathway during CPB by producing procoagulant cells and enzymes that enter the general circulation. (ahajournals.org)
Conclusions These data provide direct evidence of TF expression, activation of the extrinsic coagulation pathway, and thrombin formation in the surgical wound. (ahajournals.org)
During CPB, the contact system of plasma proteins 3 and the intrinsic coagulation pathway are stimulated by contact with large areas of nonendothelialized biomaterials in the extracorporeal circuit. (ahajournals.org)
Recent reports have reevaluated the relative roles of the intrinsic and extrinsic coagulation pathways during clinical cardiac surgery 5 6 and have provided indirect evidence that the extrinsic coagulation pathway is activated during open heart surgery. (ahajournals.org)
Evidence for stimulation of the extrinsic coagulation pathway during CPB is largely circumstantial. (ahajournals.org)
A coagulation analyzer is a type of automated analyzer that measures blood platelet levels, coagulation pathway speed, and thrombolin and thromboplastin levels in a blood sample. (sbwire.com)
This pathway is triggered by the blood coming into contact with the collagen into damaged vessel wall. (healthhype.com)
0.05), in which the blood coagulation pathway was significantly enriched. (soton.ac.uk)

PhysOrg.com) -- Some things are more fun to learn than others, and the coagulation cascade has traditionally been ranked among the less fun. (phys.org)
In this work we present coagSODA, a CUDA-powered computational tool that was purposely developed for the analysis of a large mechanistic model of the blood coagulation cascade (BCC), defined according to both mass-action kinetics and Hill functions. (hindawi.com)
Their role is to activate steps in the process called coagulation cascade(Brandt JT,1985). (ukessays.com)
Emad Tajkhorshid, PhD , professor of biochemistry, biophysics, and pharmacology at the University of Illinois, has been using molecular dynamics (MD) modeling to simulate the earliest stages in the coagulation cascade. (bcr.org)
Tajkhorshid is currently using his lubed-up model to pursue an even more ambitious goal: simulating how different coagulation proteins form complexes on the membrane surface in order to become fully activated, thereby driving the coagulation cascade forward. (bcr.org)
The pathways involved the series of chemical reactions known as the coagulation cascade. (healthhype.com)
If one chemical (blood clotting factor) is missing or fails to act appropriately, the entire cascade can be disrupted and the formation of a blood clot may not occur or arise very slowly. (healthhype.com)
This is the start of the coagulation cascade. (healthhype.com)
The formation of fibrin during haemostasis stems from local exposure of TF (tissue factor) and the consequential activation of the coagulation cascade leading to the generation of thrombin at the site of injury. (biochemsoctrans.org)
TF serves as a cellular receptor and cofactor for plasma FVIIa, the enzyme initiating the coagulation protease cascade, leading ultimately to the generation of thrombin and fibrin. (biochemsoctrans.org)
The protein Tissue Factor (TF) initiates this cascade when blood vessels are disrupted, but how this cascade is triggered in the absence of exogenous TF remains the subject of much debate. (pubmedcentralcanada.ca)

Human Blood Coagulation. (annals.org)

These proteins, in fact, showed peculiar properties, being able to interfere with synaptic homeostasis other than coagulation itself. (mdpi.com)
Endogenous substances, usually proteins, that are involved in the blood coagulation process. (jove.com)
Once clot is formed, other blood coagulation proteins take place in the body(Thijs,1993). (ukessays.com)
The most likely causes of the hemorrhagic tendencies of this disease in infected monkeys were thrombocytopenia and decreased synthesis of coagulation and other plasma proteins due to severe hepatocellular necrosis. (ajtmh.org)
The market size of recombinant and plasma-derived coagulation factor products exceeded US$ 7.5 bln in 2008, the majority (US$ 5.5 bln) generated by recombinant proteins. (pipelinereview.com)

Researchers within The Didar Lab and the Michael G. DeGroote Institute for Infectious Disease Research , created a novel surface modification process applied to catheters to lower the risk of blood thrombosis. (mcmaster.ca)
The CVD method is a simple, straightforward, and non-invasive procedure, with the potential to not only prevent catheter thrombosis, but also thrombosis associated with other widely used blood contacting medical devices. (mcmaster.ca)
Blood-contacting medical devices such as catheters, heart valves and vascular grafts are prone to thrombosis, which can lead to thromboembolic complications and device failure," explained Maryam Badv, PhD candidate, School of Biomedical Engineering and lead author on the study. (mcmaster.ca)

The report studies the industry for (Blood Coagulation Analyzer Market) mainly covers 13 Topics acutely display the global Blood Coagulation Analyzer Market. (sbwire.com)

this polymerizes into fibrin strands which reinforce the platelet plug and form a blood clot. (springer.com)
23230 B Claims ABSTRACT OF THE DISCLOSURE A freshly drawn sample of venous blood is placed in a container, such as a hypodermic syringe, and a thread is moved lengthwise through the sample until a substantially continuous mass of fibrin and/or red blood cells form thereon, marking the endpoint of the test. (google.com)
The coagulation factor VIII is a robust initiator of thrombin which is later required for the generation of fibrin to form a platelet plug and its gene is expressed in the X chromosome. (drugbank.ca)
Blood coagulation is viewed as a process resulting in fibrin polymerization, which is considered as the first step towards thrombi formation. (aimsciences.org)
14 the tilt-tube method, where the tube containing a blood sample is tilted back and forth until a fibrin network is formed, and the wire-loop technique, where a wire loop is passed through the mixture until a clot forms and adheres to the loop. (spiedigitallibrary.org)
High-quality serum thus is obtained by Iater centrifugation, free from the cracking of blood corpuscle, hemolysis, separation of fibrin protein, etc. (alibaba.com)
It binds to the fibrin component of the thrombus (blood clot) and selectively converts thrombus-bound plasminogen to plasmin, which degrades the fibrin matrix of the thrombus. (wikipedia.org)

Essential Guide to Blood Coagulation has been updated to include the new anticoagulants and now has a dedicated chapter on antiplatelet drugs. (wiley.com)

The results demonstrated stronger inhibition of endogenous thrombin potential by argatroban than by DX-9065a, especially when coagulation was initiated at higher tissue factor concentrations, while argatroban appeared to be slightly less potent in its ability to prolong clot time. (ebi.ac.uk)
The reaction sequence is initiated by the expression of tissue factor on the surface of activated cells and results in the generation of thrombin, the most important enzyme in blood clot formation. (nih.gov)
On the assumption that the processes which lead to the development of an in vitro clot are analogous to those which produce in vivo thrombi, techniques have been developed for in vitro coagulation studies. (google.com)
Due to this deficiency, the blood cannot clot properly and the patients that present this disease are prone to prolonged or excessive bleeding. (drugbank.ca)
The app connects via Bluetooth to the CoaguChek XS meter, which patients use to test PT/INR, the time it takes for blood to clot. (fiercebiotech.com)
the blood changes from a liquid to a gel or semi-solid state, forming a blood clot. (bibliotecapleyades.net)
Most systems currently measuring the clotting time use one of the two following principles: the immobilization of a moving probe immersed in the sample when a clot is formed 15 , 16 or the change in optical density of the mixture when coagulation has occurred. (spiedigitallibrary.org)
The blood sample will completely contact with coagulant and clot within 5-8mins. (alibaba.com)
Blood coagulation is the process of forming a blood clot . (healthhype.com)
Nevertheless, the net result of all the processes is to conclude with the formation of a blood clot. (healthhype.com)
During blood coagulation, changes in the viscoelastic properties of the clot restrict Brownian displacements of light scattering centers within the sample, altering the rate of speckle intensity fluctuations. (osapublishing.org)
CTI-treated human blood will clot in vitro due to the combined activity of XIIa and XIa, a process enhanced by platelet activators and which proceeds in the absence of any evidence for kinetically significant blood borne tissue factor. (pubmedcentralcanada.ca)
Dilute Russell's viper venom time (dRVVT) is a laboratory test often used for detection of lupus anticoagulant (LA). Russell's viper venom (RVV) was known to clot blood many years ago. (wikipedia.org)

A concise full-color overview of the mechanisms of blood ailments and issues - in accordance with a Harvard clinical university hematology course2015 Doody's center name! (bitmicro.com)
This new report provides analyses of 100 major and emerging suppliers of immunodiagnostics, microbiology, cancer diagnostic, molecular diagnostic, hematology, coagulation and blood banking instruments and reagents. (aarkstore.com)

This study demonstrates differential inhibition of thrombin generation by fXa and thrombin inhibitors and has implications for the pharmacological regulation of blood coagulation by the anticoagulant protease inhibitors. (ebi.ac.uk)

Still another object is to provide test methods and apparatus for determination of blood coagulation time which may be essentially fully automated, being subject little, if at all, to human error or judgment. (google.com)
A highly sensitive label-free assay for the determination of blood coagulation Factor XIII activity is demonstrated through the controlled assembly of peptide-functionalized gold nanoparticles (AuNPs). (rsc.org)

The extrinsic-intrinsic model of blood clotting has in recent years given way to a new cell-based model of clotting. (healthhype.com)

Intestinal bleeding, however, did not correlate with abnormalities of coagulation tests. (nih.gov)
Also, the ameliorating and counteracting effects of CAPE on different disease modalities of hematological, blood coagulation, and vascular abnormalities have recently been emerged. (hindawi.com)
The disease in infected animals was also characterized by the development of hypotension and coagulation abnormalities as indicated by severe thrombocytopenia and prolongation of the activated partial thromboplastin time. (ajtmh.org)

The aim of this study was to assess the contribution of BAL treatment on blood coagulation parameters. (nih.gov)
We aimed to evaluate blood coagulation parameters and platelet indices as potential predictors for the onset and severity of PE. (plos.org)
Furthermore, OCT has the potential to represent the process of flowing blood coagulation with proper parameters. (spiedigitallibrary.org)
Dr Christine Nadziejko of the New York University School of Medicine hypothesized that exposure of healthy rats to ambient particles may cause changes in blood coagulation parameters. (epa.gov)
The investigators objective is to prove the hypothesis that particulate matter may exert its adverse health effects by altering blood coagulation parameters. (epa.gov)
Dr. Nadziejko and her colleagues at the New York University School of Medicine plan to evaluate the effects of exposing healthy rats to concentrated ambient particles (CAPs) and changes in blood coagulation parameters. (epa.gov)
Investigators expect the results to show altered blood coagulation parameters in rats exposed to CAPs. (epa.gov)
The kinetic model consisting of 76 ordinary differential equations (76 species, 57 reactions, 105 kinetic parameters) predicted the clotting of resting and convulxin-activated human blood as well as predicted T i of human blood under 50 different initial conditions that titrated increasing levels of TF, Xa, Va, XIa, IXa, and VIIa. (pubmedcentralcanada.ca)
In such procedures blood parameters can drastically change within the lapse of a few seconds to minutes due to exposure of patients' haemostatic system to large disturbances such as haemo-dilution or anticoagulation. (omicsonline.org)
Changes in platelet function and some plasma parameters of coagulation exhibit a significant correlation to base excess, pH and lactate. (springer.com)
We found an abnormal pattern of coagulation parameters and association of advanced age and comorbidities with a high rate of mortality in severe COVID-19 patients, which should be taken into consideration in their hospital management. (who.int)
There is no available study related to the evaluation of coagulation parameters in COVID-19 patients from the Islamic Republic of Iran. (who.int)
The aims of the present study were to find the coagulation profile of 74 consecutive ICU-admitted patients with COVID-19 from Kermanshah Province, Islamic Republic of Iran, and to determine the influence of age and comorbidities on the level of these parameters. (who.int)
In addition, we aimed to compare coagulation parameters between survivors and non-survivors to detect their effects on the severity and outcome of the disease. (who.int)

Deerfield Beach, FL -- ( SBWIRE ) -- 01/01/2018 -- The report that is written on the titled Blood Coagulation Analyzer Market 2017 covers all the aspects of the global market study. (sbwire.com)
In this report, the global Blood Conservation System market is valued at USD XX million in 2017 and is expected to reach USD XX million by the end of 2025, growing at a CAGR of XX% between 2017 and 2025. (reportsnreports.com)

Blood coagulation is a basic physiological defense mechanism that occurs in all vertebrates to prevent blood loss following vascular injury. (nih.gov)
The realization that TF of blood vessels is predominantly localized in adventitia, deeply hidden away from the vessel lumen, prompted the launching of an 'envelope' theory, entailing the notion of TF as a haemostatic envelope encapsulating the vascular bed, already present for initiating blood clotting should the integrity of the vasculature be compromised [ 8 ]. (biochemsoctrans.org)

Refinement of this model by Xray crystallography and NMR spectroscopy coupled to biochemical studies of protein-membrane interaction remain major areas of interest to understand protein complex formation on membrane surfaces during blood coagulation. (bidmc.org)
in all mammals, coagulation includes both a cellular (platelet) and a protein (coagulation factor) component. (omicsonline.org)
The protein is increasingly produced when clots have already formed in the blood vessels. (thieme.com)
CONCLUSIONS: This study identified novel protein-level molecular indicators on the sexually dimorphic effect of vitamin D status correction associated with blood coagulation among overweight adults. (soton.ac.uk)

Elliott D.L. (1978) Mathematical Models of Blood Coagulation Kinetics. (springer.com)
The "Platelet-Plasma" model lays the groundwork for integration of coagulation reaction kinetics and donor specific descriptions of platelet function. (pubmedcentralcanada.ca)

This study was designed to determine whether blood contact with the surgical wound activated monocytes to express TF and stimulated the extrinsic coagulation system to produce thrombin during clinical cardiac surgery. (ahajournals.org)

Reasons that cause coagulation issues include liver disease, thrombophilia and hemophilia. (sbwire.com)
Additionally some unwanted interactions of the blood with artificial surfaces may cause coagulation activation, blood platelet aggregation [ 5 ] or proinflammatory effects [ 6 , 7 ]. (omicsonline.org)

Impact of different storage times at room temperature of unspun citrated blood samples on routine coagulation tests results. (ovid.com)

Evacuated collection tubes must be filled to completion to ensure that a 9:1 blood-to-anticoagulant ratio is achieved. (labcorp.com)
The sample should be mixed immediately by three to six complete gentle end-over-end inversions to ensure adequate mixing of the anticoagulant with the blood. (labcorp.com)
Moreover, according to the International Self-Monitoring Association of Oral Anticoagulated Patients (ISMAAP), nearly four milion people are under oral anticoagulant therapy in Europe and need to monitor their coagulation time daily to self-adjust the dosage of their treatment and thus maintain the optimal therapeutic range. (spiedigitallibrary.org)

Faced with a bleeding patient, it may be difficult to determine whether blood loss is due to a local factor, or an underlying hemostatic defect. (wiley.com)
Also searched for Hemostatic disorder and Coagulation disorder . (clinicaltrials.gov)
Faced with a bleeding sufferer, it can be tough to figure out even if blood loss is because of an area issue or an underlying hemostatic illness. (bitmicro.com)
Almost the entire hemostatic mechanism is regulated by various chemicals that are in constant circulation in the blood stream. (healthhype.com)

Patients with elevated hematocrits have a relatively low amount of plasma for a given whole blood (collection) volume. (labcorp.com)
An onion-olive-oil combination reduces arterial blood pressure, plasma viscosity and hematocrit, indicating the cardiovascular benefits of a Mediterranean diet. (greenmedinfo.com)
3. A moderate to marked prolongation of the coagulation time of the plasma was recorded in guinea pigs that had received repeated doses of ethionine. (jimmunol.org)
Methods and Results Blood samples taken from 20 consenting patients who had elective cardiac surgery were assayed for peripheral blood mononuclear cell tissue factor (TF) expression, plasma F1.2, and factor VII and VIIa concentrations. (ahajournals.org)
A surface plasmon resonance (SPR) apparatus was used to investigate blood plasma coagulation in real-time as a function of thromboplastin and heparin concentrations. (spie.org)
Nine of the 17 venoms here tested were found capable of coagulating citrated blood or plasma. (rupress.org)
HES200 has a greater effect on blood cells and plasma separation than does HES130. (unboundmedicine.com)
Transfusion rates of allogeneic blood products (Red blood cells = RBC, Fresh frozen plasma = FFP, Platelet concentrates = PLT) and patient adverse outcomes in two cohorts before and after the implementation of a SONOCLOT based coagulation management algorithm were evaluated on an observational basis in 1754 patients undergoing different types of cardiac surgery. (clinicaltrials.gov)
BACKGROUND OF THE INVENTION Blood coagulation is a complex chemical and physical reaction that occurs when blood (herein, 'blood' shall mean whole blood, citrated blood, platelet concentrate, plasma, or control mixtures of plasma and blood cells, unless otherwise specifically called out, and may include heparinized blood) comes into contact with an activating agent, such as an activating surface or an activating agent. (google.com)
Biochemical markers evidenced by cellular ischemia and injury/dysfunction included increased plasma levels of blood urea nitrogen (BUN), creatinine, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and alkaline phosphatase (ALP) were all elevated during heatstroke. (sigmaaldrich.com)
however, in case of any injury disrupting the endothelium, it can no longer detain plasma factor VII [FVII (coagulation factor VII)] or FVIIa (activated FVII) from binding to TF. (biochemsoctrans.org)
Although not yet proven, the normally occurring trace amounts of FVIIa in the circulating plasma might provide for the enzymatic potential of the very first FVIIa-TF complexes, formed on injury-related exposure to the blood of extravascular TF sites, thus initiating the cascading process. (biochemsoctrans.org)
Clotting of blood involves a series of reactions wherein at each step an inactive zymogen is converted to an active enzyme by the product of the previous step, sometimes in plasma and usually on efficient catalytic surfaces provided by the activating platelet. (pubmedcentralcanada.ca)
Effects of different plasma substitutes on blood coagulation: a comparative review. (pptaglobal.org)
OBJECTIVE: To compare the effects of different colloid plasma substitutes on blood coagulation and postoperative blood loss. (pptaglobal.org)
Multivariate analysis of covariance and regression analysis controlled for age, body mass index, mean arterial blood pressure, heart rate, and norepinephrine plasma level. (uzh.ch)
There might be a dose-response relationship between the plasma concentration of melatonin and coagulation activity. (uzh.ch)
TRANFUSION of packed red blood cells (PRBC), fresh frozen plasma (FFP), cryoprecipitate, and platelet concentrates is strongly associated with increased morbidity and mortality in cardiovascular surgery, patients with myocardial infarction, and critically ill patients. (asahq.org)

This report offers key statistics on the market status of the Blood Coagulation Analyzer Manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the Blood Coagulation Analyzer Industry. (sbwire.com)
Additionally, the Blood Coagulation Analyzer industry development trends and marketing channels are analysed. (sbwire.com)
This estimation covers Blood coagulation analyzer industry key vendor's examination based on the company's synopsis, Blood coagulation analyzer company profiles, financial study, market revenue, and opportunities by leading topographical regions. (einpresswire.com)
The Blood coagulation analyzer industry advancement trends and advertising channels have also been studied. (einpresswire.com)
The Blood coagulation analyzer research analysis includes all facets of the Blood coagulation analyzer market worldwide, which begins with the definition of the Blood coagulation analyzer industry and progress towards Blood coagulation analyzer market segments. (einpresswire.com)
The leading manufacturers influence the operations in the Blood coagulation analyzer industry impute to their strong geographical extend and huge production facilities. (einpresswire.com)

When the inflammation-coagulation interactions overwhelm the natural defence systems, catastrophic events occur, such as manifested in severe sepsis or inflammatory bowel disease. (labome.org)
Combination treatment with Gua Sha and Blood-letting causes attenuation of systemic inflammation, activated coagulation, tissue ischemia and injury during heatstroke in rats. (sigmaaldrich.com)
We used repeated measurements to examine the association of long-term fine and ultrafine particle exposure with several blood markers of inflammation and coagulation. (bmj.com)

Tabuchi and colleagues 7 observed increased fibrinolytic activity in blood aspirated from the pericardial cavity during clinical cardiac surgery and suggested that raising pericardial blood heparin concentrations may reduce blood activation during CPB. (ahajournals.org)
In PE patients, the coagulation-fibrinolytic system is thought to be one of the most seriously affected systems by maternal inflammatory reactions and immune dysfunction [5] . (plos.org)
In light of this, the present study aims to systemically evaluate the blood coagulation and fibrinolytic systems in CAE patients. (ovid.com)
Disequilibrium of the coagulation/fibrinolytic system may contribute to thrombus formation and clinical coronary events in patients with CAE. (ovid.com)
Bennett NB, Ogston CM, Ogston D. The effect of prolonged exercise on the components of the blood fibrinolytic enzyme system. (springer.com)

Tissue factor (TF) can also stimulate the transcription of the gene encoding VEGF-A. The relationship between coagulation and angiogenesis in myeloproliferative neoplasms is not fully understood. (mdpi.com)
When the blood vessel wall is damaged, the tissue releases tissue factor also known as tissue thromboplastin ( Factor III ). (healthhype.com)
The transmembrane glycoprotein TF (tissue factor) plays an essential role in haemostasis as the principal initiator of blood coagulation. (biochemsoctrans.org)
This invention provides a method of inhibiting coagulation in extracorporeal circulation in a subject, comprising administration of a therapeutically effective amount of a monoclonal antibody which inhibits the ability of tissue factor to bind to factor VII/VIIa. (google.com)
The method prevents complex formation between tissue factor and factor VII/VIIa and thus inhibits coagulation of blood in extracorporeal procedures such as cardiopulmonary bypass and other shunt procedures. (google.com)

Different blood conservation strategies were used and included consistently cell salvage, standardized application of tranexamic acid and retrograde autologous cardiopulmonary bypass (CPB) priming. (clinicaltrials.gov)

This lets him cover a larger territory in the circulatory system at a longer timescale, modeling changes in blood viscosity and simulating the kinds of abnormal red blood cell aggregation that occurs in diseases such as atherosclerosis, AIDS, myeloma, and diabetes mellitus. (bcr.org)

14 - 18 However, these studies vary widely with respect to the scope of POC measurements performed, availability and use of coagulation factor concentrates, and by consideration of either the intraoperative or postoperative period. (asahq.org)

L1106] Hemophilia A is a hereditary hemorrhagic disorder generated by the congenital deficit of the coagulation factor VIII. (drugbank.ca)
Hemophilia A, a genetic bleeding disorder, is often caused by chromosomal inversions that involve a portion of the blood coagulation factor VIII ( F8 ) gene that encodes one of the key enzymes in blood clotting. (pnas.org)
In hemophilia, there, which is an x-linked inherited coagulation disorder, there is a defect in what? (brainscape.com)

Objectives Changes in air temperature are associated with an increase in cardiovascular events, but the role of procoagulant and proinflammatory blood markers is still poorly understood. (bmj.com)

For use in the emergency reversal of coagulation factor deficiency in patients receiving vitamin K antagonist therapy. (drugbank.ca)
Earlier this year, Roche launched the CoaguChek INRange system in Europe , which helps patients and doctors monitor coagulation and response to vitamin K antagonist therapy. (fiercebiotech.com)

The first epidermal growth factor-like domain (EGF-1) from blood coagulation factor VII (FVII) contains two unusual O-linked glycosylation sites at Ser-52 and Ser-60. (rcsb.org)

The thread is of a material to which blood coagulation substances adhere, preferably a water wettable material such as glass, or plant or animal fibers, e.g., cotton or wool. (google.com)

The preventative effect of caffeic acid phenyl ester (CAPE) against hematological, blood coagulation, and hepatorenal disturbances in cadmium (Cd) intoxication was investigated in rats. (hindawi.com)
It is concluded that CAPE is a promising compound that can counteract the hematological and blood coagulation disturbances, oxidative stress, and hepatorenal damages in Cd intoxication. (hindawi.com)
Professor Francesco Violi at Sapienza University of Rome suspects that the disturbances in the blood clotting mechanism play a central role in the disease. (thieme.com)

Today marks the third lustrum of the annual international sympo- sium on blood transfusion, organized by the Rode Kruis Bloedbank Groningen-Drenthe. (springer.com)
I am happy to note that the initiative has been successful: over the past fourteen years the Rode Kruis Bloedbank Groningen-Drenthe has succeeded in organizing an annual symposium on blood transfusion, with a different theme each year, and with an average attendance of 250 participants from some 26 countries world-wide. (springer.com)
Implementing coagulation management algorithms based on Point-of-care (POC) testing devices such as thromboelastography (TEG) or rotational thromboelastometry (ROTEM) have been shown to reduce transfusion rates and the occurrence of adverse patient outcomes. (clinicaltrials.gov)
Indication for red blood cells (RBC) transfusion were a hematocrit (HCT) level below 21% during CPB, below 25% for patients with preserved left ventricular function and 28% for patients with a left ventricular function ≤ 30% and patients undergoing emergency procedures. (clinicaltrials.gov)
This goal was motivated historically by known blood risks including transmissible infectious disease, transfusion reactions, and potential effects of immunomodulation. (minervamedica.it)
There is a pressing need for this new "standard of care" so as to reduce blood transfusion and promote the availability of transfusion alternatives. (minervamedica.it)
Patient blood management therefore encompasses an evidence-based medical and surgical approach that is multidisciplinary (transfusion medicine specialists, surgeons, anesthesiologists, and critical care specialists) and multiprofessional (physicians, nurses, pump technologists and pharmacists). (minervamedica.it)
3 - 13 Furthermore, blood transfusion is associated with prolonged hospital stay as well as increased hospital costs. (asahq.org)
Smaller studies suggest that implementation of point-of-care (POC) coagulation tests coupled to algorithm-based management decreases transfusion requirements in cardiac surgery. (asahq.org)

Surface-energy dependent contact activation of blood factor XII. (nextbio.com)
The simultaneous increase of TF concentration and activity, VEGF-A in the blood of patients with ET, as well as a positive correlation between the concentration of TF and VEGF-A demonstrates the coexistence of TF-dependent coagulation and activation of angiogenesis. (mdpi.com)
Acute exercise causes a temporary short lasting activation of blood coagulation, platelet function and the prostaglandin system, the extent of these alterations being significantly less pronounced in well trained athletes than in untrained persons. (springer.com)

This can be potentially dangerous, because when blood coagulates or clots, it can get stuck and prevent blood flow. (bibliotecapleyades.net)
When blood clots, it can't enter the capillary system to facilitate the exchange of oxygen and carbon dioxide. (bibliotecapleyades.net)
Blood Coagulation (thrombogenesis) is the intricate process by which blood forms clots. (omicsonline.org)
Hyperactivity of the blood coagulation process (thrombophilia) could explain why many patients suffer a heart attack or stroke, which are caused by blood clots in the coronary or cerebral arteries. (thieme.com)

Their utility as molecular wires has also led to their incorporation into redox reactions in higher‐order organisms, where they participate in numerous physiological processes, including blood coagulation. (intechopen.com)

Pro-coagulation tube is used in blood collection for biochemistry and immunology in medical inspection. (alibaba.com)

It is also indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA, e.g., warfarin) therapy in adult patients with acute major bleeding or who require rapid reversal of therapy. (drugbank.ca)
Patients with typhoid fever were studied to determine whether disseminated intravascular coagulation (DIC), circulating bacteria, and endotoxemia were responsible for the signs and symptoms of their illnesses. (nih.gov)
In 25 patients with positive blood cultures for Salmonella typhi, quantitative cultures detected from less than 10 to 9 x 10(2) bacteria/ml. (nih.gov)
Roche unveiled a new app for patients on anticoagulation therapy, allowing them to see results from their at-home blood clotting tests on an iOS device. (fiercebiotech.com)
In India, Dr. Subhasmita Swain at SOA University developed a biomedical patch that can coagulate blood flow in patients . (biofuelsdigest.com)
Data analysis focusing on coagulation management using a dedicated algorithm in the present quality control study is done for 1754 out of 2199 consecutive patients undergoing cardiac surgery comprising the initial cohort from 2009 to 2011 (before implementation of the algorithm) and the subsequent cohort from 2013 to 2015 (after implementation of the algorithm). (clinicaltrials.gov)
The aim of this study was to evaluate the concentration of TF in relation to VEGF-A in the blood of patients with essential thrombocythemia (ET). (mdpi.com)
The aim of this prospective, nonrandomized study was to investigate the potential contribution of a monopolar soft-coagulation device to the limitation of intraoperative blood loss in patients undergoing TLH. (sages.org)
In CAE patients, the circulating coagulation system was normal. (ovid.com)
Patients with hemophilia A have a deficiency in which coagulation factor? (brainscape.com)
Blood management focus on the perioperative management of patients undergoing surgery or other invasive procedures in which significant blood loss occurs or is expected. (minervamedica.it)
The main aim of the present study was to find the coagulation profile of intensive care unit (ICU) admitted patients with COVID-19 from Kermanshah, Islamic Republic of Iran. (who.int)
More comparison of reports from various populations related to the clinical course, outcome of COVID-19 and blood coagulation profile in these patients are necessary to help the management and treatment of the disease. (who.int)

E. W. Davie, K. Fujikawa, M. E. Legaz and H. Kato, "Role of Proteases in Blood Coagulation," in Proteases and Biological Control , ed. by E. Reich et al, Vol. 2 of Cold Spring Harbor Conference on Cell Proliferation, 1975. (springer.com)
Coagulation, meanwhile, involves a complicated dance between cell membranes and biological molecules. (bcr.org)
Conclusions The authors observed different temperature effects on blood markers in two potentially susceptible groups probably indicating varying underlying biological mechanisms. (bmj.com)

Takeda tapped Roche's Foundation Medicine to develop tissue- and blood-based companion diagnostic tests for its portfolio of lung cancer therapies. (fiercebiotech.com)
Algorithm for LA testing with dRVVT screen and confirm reagents This in vitro diagnostic test is based on the ability of the venom of the Russelli viper to accelerate blood clotting. (wikipedia.org)

However Information regarding a SONOCLOT based coagulation management algorithm however is lacking. (clinicaltrials.gov)

Blood coagulation in anhepatic pigs: effects of treatment with the AMC-bioartificial liver. (nih.gov)
It has been proved that after exposure, Cd enters the blood and binds to the erythrocyte membranes and blood albumin and then is transported to liver, where it bounds to metallothionein (MT) [ 9 ]. (hindawi.com)
The Cd-MT complex is then released back into circulation [ 9 ] and accumulates in the blood system, kidney, liver, lung, testis, brain, and bone [ 10 ]. (hindawi.com)
1) For detachment of the vein, a monopolar soft-coagulation device is pressed on the resection surface of the liver to crush hepatocytes (hepatocyte crush method: HeCM). (sages.org)

BACKGROUND OF THE INVENTION The present invention relates to the testing of blood coagulation or clotting time and, more particularly, to novel and improved methods and apparatus for invitro testing of coagulation of fresh samples of venous blood. (google.com)
A further major object is to provide blood coagulation test methods and apparatus which generally operate 3,814,585 Patented June 4, 1974 to provide a test endpoint in less time than conventional tests providing the same information. (google.com)
To consider the effect of blood flow, in the present study, d 1/e versus time from the coagulating porcine blood circulated in a mock flow loop with various steady laminar flows at mean flow speed in the range from 5 to 25 mm/s . (spiedigitallibrary.org)
The results showed that there were positive correlations between coagulation time (t c ) and HCT, velocity, and tubing size, respectively. (spiedigitallibrary.org)
Elasticity varied with time from 50 Pa at coagulation to 1300 Pa at 120 minutes. (archives-ouvertes.fr)
A system and method for determining a coagulation time, e.g. (google.com)
Resistance to agitator movement due to coagulation is detected, and the coagulation time is measured. (google.com)
Ongoing patent expirations and failed life cycle management efforts leave the established companies vulnerable regarding the future growth perspective of their recombinant coagulation factor business, but at the same time opens the door to potential new market entrants. (pipelinereview.com)
We demonstrated that affinity based poly ethylene NPs absorbed to polymer films on the QCM constitute a powerful tool with no need for pretreatment for measuring PT in whole blood samples in real time, while these coatings are reusable up to 10 times. (omicsonline.org)

APTT was usually prolonged when patient had less than 30% levels of normal coagulation activity. (ukessays.com)

L1053] The hemophilia A is characterized by the deficiency of the coagulation factor VIII that results in prolonged blood flow after injury or surgery as well as recurrent bleeding. (drugbank.ca)

We have developed and investigated a novel optical approach, Laser Speckle Rheology (LSR), to evaluate a patient's coagulation status by measuring the viscoelastic properties of blood during coagulation. (osapublishing.org)

Experiments with combined anti-XI and anti-XII antibodies prevented thrombin production, demonstrating that a leak of XIIa past saturating amounts of CTI (and not "blood-borne TF" alone) was responsible for in vitro initiation without added TF. (pubmedcentralcanada.ca)

The synthesis of a series of novel macrocyclic compounds designed to target blood coagulation Factor XIa is described. (diva-portal.org)

Anatomy12

Organisms15

Diseases26

Chemicals and Drugs120

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes33

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science3

Named Groups1

Health Care2

Exosites 1 and 2 are essential for protection of fibrin-bound thrombin from heparin-catalyzed inhibition by antithrombin and heparin cofactor II. (1/3556)

Nonanticoagulant heparin prevents coronary endothelial dysfunction after brief ischemia-reperfusion injury in the dog. (2/3556)

Distinct contributions of residue 192 to the specificity of coagulation and fibrinolytic serine proteases. (3/3556)

Age-related changes in blood coagulation and fibrinolysis in mice fed on a high-cholesterol diet. (4/3556)

PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. (5/3556)

Antithrombotic efficacy of thrombin inhibitor L-374,087: intravenous activity in a primate model of venous thrombus extension and oral activity in a canine model of primary venous and coronary artery thrombosis. (6/3556)

Risk of clot formation in femoral arterial sheaths maintained overnight for neuroangiographic procedures. (7/3556)

Thrombelastographic changes and early rebleeding in cirrhotic patients with variceal bleeding. (8/3556)

Blood Coagulation

Blood Coagulation Factors

Blood Coagulation Tests

Disseminated Intravascular Coagulation

Blood Coagulation Disorders

Thromboplastin

Factor Xa

Prothrombin Time

Factor VII

Partial Thromboplastin Time

Factor X

Prothrombin

Factor IX

Thrombelastography

Factor VIIa

Thrombin

Factor XIII

Whole Blood Coagulation Time

Factor XIa

Factor VIII

Fibrinolysis

Carbon-Carbon Ligases

Coagulants

Antithrombin III

Hemostasis

Protein C

Fibrinogen

Factor V

Factor IXa

Hydroxyethyl Starch Derivatives

Thrombin Time

Factor XIIa

Anticoagulants

Fibrin

Plasma Substitutes

Factor XII

Factor XI

Vitamin K

Factor XI Deficiency

Antithrombins

Factor XII Deficiency

Fibrin Fibrinogen Degradation Products

Factor VIIIa

Thrombosis

Blood Platelets

Factor Va

Heparin

Thrombomodulin

Hemophilia A

1-Carboxyglutamic Acid

Kaolin

Protein S

Argon Plasma Coagulation

Hemophilia B

Blood Coagulation Disorders, Inherited

Hypoprothrombinemias

Coagulation Protein Disorders

Prekallikrein

Fibrinopeptide A

Amino Acid Sequence

Vitamin K Deficiency

Platelet Activation

Molecular Sequence Data

Serine Proteinase Inhibitors

Platelet Aggregation

Factor X Deficiency

Viperidae

Transglutaminases

Laser Coagulation

Hemostatics

Binding Sites

Hemorrhage

Polygeline

Kinetics

Recombinant Proteins

Electrocoagulation

Arcidae

Kallikreins

alpha-2-Antiplasmin

Factor VII Deficiency