Death, Sudden
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Changes in haematological parameters and iron metabolism associated with a 1600 kilometre ultramarathon. (1/1800)
OBJECTIVE: To investigate haematological variations and iron related changes in the serum of participants in a 1600 kilometre ultramarathon run. PARTICIPANTS: Seven male and two female participants in a 1600 km foot race. METHODS: Blood samples were obtained from the participants before, after four and 11 days of running, and at the end of the event. Samples were analysed by standard methods for haemoglobin, packed cell volume, total red cell count, mean red cell volume, mean red cell haemoglobin, total white cell count and differential, platelets, reticulocytes, iron, ferritin, total iron binding capacity, percentage transferrin saturation, haptoglobin, and bilirubin and corrected for changes in plasma volume. RESULTS: The following variables decreased during the event (p < 0.05): haemoglobin, packed cell volume, mean red cell volume, percentage lymphocytes, percentage monocytes, serum iron, total iron binding capacity, and percentage transferrin saturation. Increases (p < 0.05) were found in plasma volume, total red cell count (day 4 only), total white cell count, percentage and absolute numbers of neutrophils and reticulocytes, absolute numbers of lymphocytes and monocytes (day 4 only), absolute numbers of eosinophils (day 11 and race end), absolute numbers of basophils (race end only), platelets, ferritin, haptoglobin, and bilirubin (day 4 only). CONCLUSION: Ultramarathon running is associated with a wide range of changes in haematological parameters, many of which are related to the normal acute phase response to injury. These should not be confused with indicators of disease. (+info)Cardiovascular and metabolic adaptations in horses competing in cross-country events. (2/1800)
The cardiovascular and metabolic response to two cross-country events (CC*: preliminary level and CC*** advanced level) were analysed in 8 male eventing horses (4 Anglo-Hunter and 4 Anglo-Arabian). This study focused on the establishment of the main metabolic pathways involved in the muscle energy resynthesis during the competitions. Heart rate (HR) was recorded throughout the CC events. Jugular venous blood samples were withdrawn before the warm-up period, immediately after the competitions and at 5 and 10 min in the recuperation period. The following haematological parameters were studied: red blood cells (RBC), packed cell volume (PCV), haemoglobin concentration (Hb), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), white blood cells (WBC), and number and percentages of lymphocytes (LYM) and granulocytes and monocytes (GRAN). One fraction of blood was centrifuged and, in plasma, lactate (LA), total plasma protein (TPP) and the rate of LA disappearance were determined. The competitions induced significant increases in RBC, Hb, PCV, MCV and TPP. Plasma LA response exceeded the anaerobic threshold of 4 mmol/l, reaching a maximum level of 13.3 mmol/l. HR ranged from 140 to more than 200 bpm, peaking at 230 bpm, revealing a limitation in the oxygen supply to the working muscles. It was concluded that muscle energy resynthesis during a CC event is provided both through oxidative processes and glycolysis with LA formation. Therefore, both stamina and power exercises are required for eventing horses. (+info)Insulin dependent diabetes mellitus (IDDM) and autoimmune thyroiditis in a boy with a ring chromosome 18: additional evidence of autoimmunity or IDDM gene(s) on chromosome 18. (3/1800)
A 4 year 3 month old boy with insulin dependent diabetes mellitus (IDDM), autoimmune thyroiditis, slight mental retardation, facial dysmorphism, and a de novo ring chromosome 18 (deletion 18q22.3-18qter) is described. This unique association of defects could represent a chance association. Alternatively, the clinical features could be the result of the chromosomal aberration. If so, one could speculate that a gene or genes on chromosome 18 might act as a suppressor or activator of the autoimmune process by itself or in concert with other IDDM loci. (+info)Absent pituitary gland and hypoplasia of the cerebellar vermis associated with partial ophthalmoplegia and postaxial polydactyly: a variant of orofaciodigital syndrome VI or a new syndrome? (4/1800)
We report two sibs with features overlapping those of orofaciodigital syndrome type VI (Varadi syndrome). Both presented at birth with oculomotor abnormalities, dysmorphic facial features, and dysgenesis of the cerebellar vermis. There were minimal oral manifestations (high arched palate) in both of them and one had postaxial polydactyly of both hands and one foot. In addition, there was evidence of aplasia of the pituitary gland on MRI scan in both of them with evidence of hypopituitarism. Both responded well to hormone replacement therapy with improvement in their linear growth and mental ability. These cases may represent a new autosomal recessive midline defect syndrome with features overlapping OFDS VI. Alternatively the features in these children could represent variability within OFDS VI. (+info)A three-month repeated oral administration study of a low viscosity grade of hydroxypropyl methylcellulose in rats. (5/1800)
The toxicity of the lowest viscosity grade of hydroxypropyl methylcellulose (HPMC) that is currently commercially available was investigated by means of a three-month repeated oral administration study in male and female Crj:CD (SD) IGS rats at doses of 505, 1,020 and 2,100 mg/kg/day. Body weights of males and females in the 2,100 mg/kg group were lower than those of the control group on and after day 28 of administration, but the differences were not statistically significant. The degree of suppression of body weight gain in males was higher than that in females. This tendency was similar to the results in other toxicity studies of HPMC that have been reported. Males in the 2,100 mg/kg group showed a tendency (not significant) for decreased food consumption and urine volume. Examinations of general signs, hematology, blood chemistry, ophthalmology, absolute and relative organ weights, autopsy and histopathology revealed only a few, apparently coincidental, statistically significant differences from the control, and no evidence of any dose-dependent changes was found. It was concluded that the lowest viscosity grade of HPMC showed extremely low toxicity under the conditions of this study, as has been found for higher viscosity grades. (+info)Changes in physiological parameters and feeding behaviour of Atlantic salmon Salmo salar infected with sea lice Lepeophtheirus salmonis. (6/1800)
Atlantic salmon Salmo salar L. artificially infected with salmon lice Lepeophtheirus salmonis (Kroyer 1837) recovered from detrimental physiological changes and skin damage induced by preadult lice as the parasites matured. Growth rates of Atlantic salmon remained unaffected by lice infection, but food consumption decreased with increasing feeding and movement of the lice prior to and post-mating, correlating with the appearance of head erosions and detrimental changes in physiological integrity. Food consumption of the fish increased as the lice moulted to the adult stage and gravid female lice settled in a posterior location on the fish, subsequently reducing the impact of infection and allowing recovery of the skin damage. However, the impact of preadults was limited, as the decrease in food consumption of fish at 21 d post-infection had no effect on either the specific growth rate or condition factor of the fish. Furthermore, the intensity of lice infections at each of the sample days was not correlated with food consumption, specific growth rate or any of the haematological or physiological parameters measured, either before or after infection, indicating that lice intensity was independent of social dominance/subordinance. This work has provided the first evidence that infected fish can recover from the detrimental changes caused by lice infection, even when they are still infected with lice. If fish can survive the preadult stage of lice, then the mortal impact of lice infections is greatly reduced. (+info)Anthropometric, lifestyle and metabolic determinants of resting heart rate. A population study. (7/1800)
AIM: To clarify the determinants of resting heart rate at the population level in a random sample of the Belgian population. METHODS AND RESULTS: Data of 5027 men and 4150 women aged 25-74 years obtained from a Belgian nationwide survey were analysed. In multivariate analysis, blood pressure strongly correlated with heart rate in men (t = 12.4 for systolic; t = 8.8 for diastolic) and women (t = 12.0 for systolic; t = 7.7 for diastolic). Age (t = -3.4 in men; t = -8.1 in women) and height (t = -3.7 in men; t = -3.1 in women) correlated negatively with heart rate. Smoking raised heart rate in men (1-19 cigarettes.day-1, t = 6.1; > or = 20 cigarettes.day-1, t = 10.3) and women (> or = 20 cigarettes.day-1, t = 3.5). Serum phosphorus correlated negatively with heart rate (t = -3.5 in men; t = -8.3 in women). Serum log alkaline phosphatase (t = 6.7 in men; t = 7.2 in women) and serum protein (t = 5.3 in men; t = 4.4 in women) correlated positively with heart rate. CONCLUSION: At the population level, blood pressure, cigarette smoking, serum alkaline phosphatase and serum protein correlate independently, significantly and positively with heart rate, and age, height and serum phosphorus negatively. (+info)Randomized prospective study comparing cost-effectiveness of teicoplanin and vancomycin as second-line empiric therapy for infection in neutropenic patients. (8/1800)
BACKGROUND AND OBJECTIVE: The current health-care philosophy dictates that new therapies should always be evaluated for their economic impact. Along with acquisition cost, the cost of delivery, monitoring, adverse effects and treatment failure must also be considered when determining the total cost of therapy. These auxiliary costs can be significant and greatly alter the overall cost of a drug treatment. We conducted a prospective randomized study to evaluate the efficacy, safety and cost of vancomycin and teicoplanin therapy in patients with neutropenia, after the failure of empirical treatment with a combination of piperacillin/tazobactam and amikacin. DESIGN AND METHODS: Seventy-six febrile episodes from 66 patients with hematologic malignancies under treatment, neutropenia (neutrophils <500/mm3) and fever (38 degrees C twice or 38.5 degrees C once) resistant to the combination piperacillin/tazobactam and amikacin were included in the study. RESULTS: Primary success of second-line therapy was obtained in 35 cases (46%) with no significant difference between vancomycin (17/38) and teicoplanin arms (18/38). No difference in renal or hepatic toxicity related to the antibiotic therapy was observed. The average cost per patient according to glycopeptide used was $450+/-180 for the teicoplanin group and $473+/-347 for the vancomycin group. Interestingly, in the teicoplanin arm, drug acquisition accounted for 97% of the total cost, while in the vancomycin arm administration and monitoring play an important role in overall costs. INTERPRETATION AND CONCLUSIONS: In conclusion, our pharmacoeconomic analysis demonstrates that teicoplanin and vancomycin can be administered in neutropenic hematologic patients with similar efficacy and direct costs. (+info)www.medicinenet.com/sudden_death/article.htm
Sudden death is death that occurs unexpectedly and without warning, often due to a cardiac arrest or other underlying medical condition.
In the medical field, sudden death is defined as death that occurs within one hour of the onset of symptoms, with no prior knowledge of any serious medical condition. It is often caused by a cardiac arrhythmia, such as ventricular fibrillation or tachycardia, which can lead to cardiac arrest and sudden death if not treated promptly.
Other possible causes of sudden death include:
1. Heart disease: Coronary artery disease, heart failure, and other heart conditions can increase the risk of sudden death.
2. Stroke: A stroke can cause sudden death by disrupting blood flow to the brain or other vital organs.
3. Pulmonary embolism: A blood clot in the lungs can block blood flow and cause sudden death.
4. Trauma: Sudden death can occur as a result of injuries sustained in an accident or other traumatic event.
5. Drug overdose: Taking too much of certain medications or drugs can cause sudden death due to cardiac arrest or respiratory failure.
6. Infections: Sepsis, meningitis, and other severe infections can lead to sudden death if left untreated.
7. Genetic conditions: Certain inherited disorders, such as Long QT syndrome, can increase the risk of sudden death due to cardiac arrhythmias.
The diagnosis of sudden death often requires an autopsy and a thorough investigation into the individual's medical history and circumstances surrounding their death. Treatment and prevention strategies may include defibrillation, CPR, medications to regulate heart rhythm, and lifestyle modifications to reduce risk factors such as obesity, smoking, and high blood pressure.
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Browsing Information products by Subject "Blood Chemical Analysis"
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Urine11
- This study was designed to assess the concentration of various toxic elements in three body fluids: blood, urine and sweat. (nih.gov)
- Blood, urine, and sweat were collected from 20 individuals (10 healthy participants and 10 participants with various health problems) and analyzed for approximately 120 various compounds, including toxic elements. (nih.gov)
- Toxic elements were found to differing degrees in each of blood, urine, and sweat. (nih.gov)
- Biomonitoring for toxic elements through blood and/or urine testing may underestimate the total body burden of such toxicants. (nih.gov)
- HTLV-III/LAV has been isolated from blood, semen, saliva, tears, urine, cerebrospinal fluid, brain tissue, and cervical secretions and is likely to be present in other body fluids, secretions, and tissues of infected humans or experimentally infected nonhuman primates. (cdc.gov)
- Results of urine dry chemical analysis were positive for occult blood and leukocytes. (cdc.gov)
- Obtain a urine sample for myoglobin analysis. (medscape.com)
- While chemical methods for quantitative analysis of other hormones in blood and urine were in common use in the middle 1950's, such specific analytical procedures were not available for peptide hormones. (nobelprize.org)
- 5) Subject to the provisions of subsection (c) of this Code section, there is any amount of marijuana or a controlled substance, as defined in Code Section 16-13-21, present in the person's blood or urine, or both, including the metabolites and derivatives of each or both without regard to whether or not any alcohol is present in the person's breath or blood. (justia.com)
- 2) When a person undergoes a chemical test at the request of a law enforcement officer, only a physician, registered nurse, laboratory technician, emergency medical technician, or other qualified person may withdraw blood for the purpose of determining the alcoholic content therein, provided that this limitation shall not apply to the taking of breath or urine specimens. (justia.com)
- Collection of oral fluid is typically thought about less intrusive than either blood or urine, and could be an exceptional matrix to tie current drug use with behavioral disability. (x-10dz.com)
PFAS4
- A thin layer of grease proofing on the pizza box seems the perfect solution, until scientists realized that the degreasing chemicals often used are per- and polyfluoroalkyl substances, aka PFAS. (technologynetworks.com)
- But the same chemical properties that made PFAS so desirable to industry mean that these compounds accumulate in bodies and the environment. (technologynetworks.com)
- Out of 5,000-6,000 potential PFAS chemicals, the EPA has developed standards to test for roughly 40 of them to date. (technologynetworks.com)
- SPRINGFIELD, Ill. (WTVO) - Multiple states are considering bans on cosmetics and other products that contain so-called "forever chemicals," also known as PFAs. (mystateline.com)
Quantitative4
- 12. 5-Diethylamino-naphthalene-1-sulfonyl chloride (DensCl): a novel triplex isotope labeling reagent for quantitative metabolome analysis by liquid chromatography mass spectrometry. (nih.gov)
- 15. Overcoming Sample Matrix Effect in Quantitative Blood Metabolomics Using Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry. (nih.gov)
- 18. Chemical Isotope Labeling LC-MS for High Coverage and Quantitative Profiling of the Hydroxyl Submetabolome in Metabolomics. (nih.gov)
- /analysis Used for the identification or quantitative determination of a substance or its constituents and metabolites. (nih.gov)
Urinalysis1
- Urinalysis tests are different from hair or blood tests. (x-10dz.com)
SAMPLES7
- 1). This method involves the extraction of the analyte from hair samples using 30:70 sulfuric:nitric acid and subsequent analysis by cold vapor atomic fluorescence spectrometry. (cdc.gov)
- HCBD has been detected in air and water samples collected near chemical manufacturing facilities. (nih.gov)
- Position a loosened blood pressure cuff on the arm, and place a venous line for blood samples in the antecubital vein. (medscape.com)
- Obtain blood samples for the following tests: creatine kinase, ammonia, and lactate. (medscape.com)
- We obtained 78 human blood samples from areas in Haiti with high transmission of malaria and found no drug resistance-associated mutations in Plasmodium falciparum chloroquine resistance transporter and Kelch 13 genes. (cdc.gov)
- We confirmed 80 positive samples from these patients by using a nested PCR specific for the 18S rRNA gene for analysis of pfcrt and k13 genes. (cdc.gov)
- The Delaware Public Laboratory Chemical Terrorism Preparedness section has the capability to ship specimens and samples for chemical analysis to various partner laboratories within our region and throughout the United States. (delaware.gov)
Platelet3
- A Blood test exposing a low platelet count can make us susceptible to bleeding, in some cases even without an injury that we see. (x-10dz.com)
- Some of the reasons for a low Blood platelet count include autoimmune illness, where the impacted specific produces an antibody to his/her own platelets, chemotherapy, leukemia, viral infections and some medicines. (x-10dz.com)
- High Blood platelet counts are constantly found where a condition including bone marrow such as leukemia, cancer and other Blood borne conditions that are exposed by Blood test results. (x-10dz.com)
Biological3
- To measure such a small amount of ACTH with prevailing biological methods as much as 250 ml of blood was necessary! (nobelprize.org)
- The lack of specific procedures to measure peptide hormones in blood with some degree of accuracy brought about stagnation within a large section of biological and medical research. (nobelprize.org)
- A medicine screening test describes the technical analysis of a biological sample for the presence of controlled substances. (x-10dz.com)
Fluids2
- This was to become the starting-point for radioimmunological determination of insulin and, later, for all peptide hormones in blood, other fluids and tissues. (nobelprize.org)
- Detection times for drugs in oral fluids are about just like that in blood, roughly 1-24 hours. (x-10dz.com)
Hormones2
- The organs of the body produce several types of chemicals including hormones, enzymes, and other vital substances. (brighthub.com)
- A blood test can show hyper- or hypothyroidism by the concentration of thyroid hormones in a blood sample. (brighthub.com)
Glucose2
- Scientists from Zhejiang University in China reported that the potential benefits could be linked to the antioxidant properties of anthocyanins in berries and their regulation of inflammatory responses, as well as via pathways to reduce blood glucose and insulin resistance. (nutraingredients-usa.com)
- Discover how you can provide solutions to support your consumers in their search for the best meals and ingredients to regulate blood glucose in our new. (nutraingredients-usa.com)
Specimens1
- Specimens were grouped together and then shipped to the laboratory for chemical analysis. (cdc.gov)
Tissues2
19991
- 1,3-Hexachlorobutadiene was assigned a final priority of `high' carcinogenicity concern and placed on the Final Candidate list of chemicals for Committee review on August 6, 1999. (nih.gov)
Molecules1
- Purines are made from molecules, such as ATP and ADP -- the major chemicals used for energy storage in cells, but which also play a role in communications used by cells under stress, known as purinergic signaling. (eurekalert.org)
Stool1
- At QY 160, the caption was changed from Feces to Stool analysis . (nih.gov)
Screening1
- 1985. Urinary screening for potentially genotoxic exposures in a chemical industry. (cdc.gov)
Amplification2
- Three products that had the same molecular weight as those from Kato, Saitama, and Kawasaki genotypes were generated from the blood sample by using type-specific amplification. (cdc.gov)
- The current proposal, aiming the integration of "all laboratory-based process steps" in one single step, is both challenging and feasible: development of a microfluidic chip that combines blood sample processing (DNA extraction/purification, multiplex amplification) and detection of EGFR mutations in tumour DNA by means of gold and silver-nanoparticles (Ag and Au-nanoprobes). (europa.eu)
Reagent1
- The FUJI DRI-CHEM slide reagent has high reliability and stability brought by fine chemical technology cultivated through the long history of FUJIFILM in photographic film manufacturing. (fujifilm.com)
Metabolites2
- Hardly anyone will certainly test your blood for THC metabolites, unless you're in a rehab program or possibly applying for a government position. (x-10dz.com)
- THC metabolites do not remain in blood for more than a number of days. (x-10dz.com)
Toxic2
Concentration1
- Similarly, a pee drug concentration can not be reliably correlated to blood concentration or dosage. (x-10dz.com)
Detect1
- Running a liver panel can reveal chemical imbalances which may detect liver damage due to toxins, hepatitis, or cirrhosis. (brighthub.com)
Drugs2
- Acute-phase whole blood was collected before administration of antimicrobial drugs. (cdc.gov)
- When checked in a specialized lab for chemical analysis, as a result traces of the drugs reveal up. (x-10dz.com)
Reveal1
- If you wonder what lab tests indicate chemical imbalance, the answer is that most tests reveal some type of information which can give a better glimpse into the internal function of the body. (brighthub.com)
Insulin1
- A high blood sugar may point to insulin resistance, a pre-cursor to diabetes. (brighthub.com)
Tests4
- What Lab Tests Indicate Chemical Imbalance? (brighthub.com)
- Tests which can show a chemical imbalance include blood sugar or a cholesterol blood test . (brighthub.com)
- 3) The person tested may have a physician or a qualified technician, chemist, registered nurse, or other qualified person of his or her own choosing administer a chemical test or tests in addition to any administered at the direction of a law enforcement officer. (justia.com)
- 4) Upon the request of the person who shall submit to a chemical test or tests at the request of a law enforcement officer, full information concerning the test or tests shall be made available to such person or such person's attorney. (justia.com)
Results2
- Long made a motion to suppress the intoxilyzer results on the basis that she had not been afforded her statutory right to an independent blood test. (findlaw.com)
- In addition, Long testified that Officer Anderson informed her that the results of the blood test would probably be higher than the intoxilyzer, so it would be to her benefit not to take it. (findlaw.com)
Products1
- The basic premise is an analysis of the normal chemical reactions and products of muscle activity. (medscape.com)
Sample5
- It can generate plasma sample by aspirating and separating the whole blood inside the PF within 1 minute. (fujifilm.com)
- Pleural fluid analysis is a test that examines a sample of fluid that has collected in the pleural space. (medlineplus.gov)
- New age diagnostic tools, such as microfluidic platforms and nanodiagnostics are emerging technologies for DNA analysis requiring lower sample volumes and providing comparable sensitivity and specificity at lower costs. (europa.eu)
- Nonetheless, sample preparation and detection of the result of a chemical analysis on-chip are still weak points in many lab-on-a-chip devices. (europa.eu)
- Motorists will be needed to carry out a blood test if this 2nd sample reveals the presence of one of these medicines. (x-10dz.com)
Potentially1
- These 144 patients were potentially eligible for genotyping analysis. (cdc.gov)
Human4
- Levels of PCBs, PCDDs and PDCFs in human milk and blood : second round of quality control studies. (who.int)
- Levels of PCBs, PCDDs, and PCDFs in human milk and blood : second round of quality control studies / edited by Erkki J. Yrjänheikki. (who.int)
- 2. Development of high-performance chemical isotope labeling LC-MS for profiling the human fecal metabolome. (nih.gov)
- 19. Chemical Isotope Labeling LC-MS for Human Blood Metabolome Analysis. (nih.gov)
Clinical1
- Awards for a Clinical Center and a Data Coordinating Center under this RFA will not be made to the same Principal Investigator to ensure that data analysis is done independently of data acquisition. (nih.gov)
Found1
- Analysis of the most predictive chemicals found they belong to certain kinds of lipids (fats that included eicosanoids and sphingolipids) and purines. (eurekalert.org)
Liver1
- The liver is a vital organ, and its function is generally impaired by chemicals. (nih.gov)
Levels1
- Blood sugar levels are remaining high. (brighthub.com)
Medicines1
- Tell your provider if you take medicines to thin the blood. (medlineplus.gov)
White1
- In a blood test, your condition manifests itself in a high white blood cell count. (brighthub.com)
Collection3
- The collection procedure was designed to provide 100 mg of hair for analysis (or at least a minimum of 50 mg). (cdc.gov)
- In addition to Fuji tubes (0.5/1.5 mL), commercially available blood collection tubes can be used as specimen tubes. (fujifilm.com)
- This is a collection of blood in the pleura. (medlineplus.gov)
High2
- Blood pressure, high. (nih.gov)
- High numbers of platelets make an individual more susceptible to Blood clot. (x-10dz.com)
Whole blood1
- DNA from the whole blood and eschar was isolated and screened for O. tsutsugamushi by using PCR primers E and B to target the 56-kDa type-specific antigen gene ( 3 ). (cdc.gov)
Methods1
- ICP/MS methods are used to determine lead in the blood of preschool children. (delaware.gov)
Remove1
- Immediately release and remove the blood pressure cuff. (medscape.com)
Specific1
- However, sequence analysis of amplicons yielded by using type-specific primers and those yielded by using primers E and B demonstrated a co-infection in the blood with 2 genotypes of O. tsutsugamushi , which were designated as ZZF-KW (661 bp, GenBank accession no. (cdc.gov)
Time1
- 17. Retention time shift analysis and correction in chemical isotope labeling liquid chromatography/mass spectrometry for metabolome analysis. (nih.gov)
Major1
- LeadingMarketResearch.coms new report is an analysis of major business opportunities emerging in the U.S. automated microbiology market during the next five years. (aarkstore.com)