Erythrocytes
Blood Cell Count
Erythrocyte Transfusion
Erythrocyte Membrane
Erythrocyte Deformability
Leukocyte Count
Leukocytes
Erythrocyte Aggregation
The formation of clumps of RED BLOOD CELLS under low or non-flow conditions, resulting from the attraction forces between the red blood cells. The cells adhere to each other in rouleaux aggregates. Slight mechanical force, such as occurs in the circulation, is enough to disperse these aggregates. Stronger or weaker than normal aggregation may result from a variety of effects in the ERYTHROCYTE MEMBRANE or in BLOOD PLASMA. The degree of aggregation is affected by ERYTHROCYTE DEFORMABILITY, erythrocyte membrane sialylation, masking of negative surface charge by plasma proteins, etc. BLOOD VISCOSITY and the ERYTHROCYTE SEDIMENTATION RATE are affected by the amount of erythrocyte aggregation and are parameters used to measure the aggregation.
Hemoglobins
Erythrocyte Aging
Hemolysis
Hematocrit
Blood Preservation
Erythrocyte Volume
Erythrocyte Indices
Osmotic Fragility
Fetal Blood
Hematopoiesis
Blood Transfusion
Anemia, Sickle Cell
Blood Viscosity
The internal resistance of the BLOOD to shear forces. The in vitro measure of whole blood viscosity is of limited clinical utility because it bears little relationship to the actual viscosity within the circulation, but an increase in the viscosity of circulating blood can contribute to morbidity in patients suffering from disorders such as SICKLE CELL ANEMIA and POLYCYTHEMIA.
Erythropoiesis
The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.
Anion Exchange Protein 1, Erythrocyte
A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.
Hemorheology
Anemia, Hemolytic
Plasmodium falciparum
Lymphocytes
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Reticulocyte Count
Blood Component Transfusion
The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.
Rh-Hr Blood-Group System
Plasma
Blood Platelets
Blood Grouping and Crossmatching
Testing erythrocytes to determine presence or absence of blood-group antigens, testing of serum to determine the presence or absence of antibodies to these antigens, and selecting biocompatible blood by crossmatching samples from the donor against samples from the recipient. Crossmatching is performed prior to transfusion.
Leukocytes, Mononuclear
Spherocytosis, Hereditary
Technetium
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
Erythropoietin
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Glycophorin
The major sialoglycoprotein of the human erythrocyte membrane. It consists of at least two sialoglycopeptides and is composed of 60% carbohydrate including sialic acid and 40% protein. It is involved in a number of different biological activities including the binding of MN blood groups, influenza viruses, kidney bean phytohemagglutinin, and wheat germ agglutinin.
Granulocytes
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Rheology
Blood Substitutes
Blood Proteins
Sheep
Rosette Formation
The in vitro formation of clusters consisting of a cell (usually a lymphocyte) surrounded by antigenic cells or antigen-bearing particles (usually erythrocytes, which may or may not be coated with antibody or antibody and complement). The rosette-forming cell may be an antibody-forming cell, a memory cell, a T-cell, a cell bearing surface cytophilic antibodies, or a monocyte possessing Fc receptors. Rosette formation can be used to identify specific populations of these cells.
2,3-Diphosphoglycerate
A highly anionic organic phosphate which is present in human red blood cells at about the same molar ratio as hemoglobin. It binds to deoxyhemoglobin but not the oxygenated form, therefore diminishing the oxygen affinity of hemoglobin. This is essential in enabling hemoglobin to unload oxygen in tissue capillaries. It is also an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate by phosphoglycerate mutase (EC 5.4.2.1). (From Stryer Biochemistry, 4th ed, p160; Enzyme Nomenclature, 1992, p508)
Antigens, CD34
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Hemolytic Plaque Technique
A method to identify and enumerate cells that are synthesizing ANTIBODIES against ANTIGENS or HAPTENS conjugated to sheep RED BLOOD CELLS. The sheep red blood cells surrounding cells secreting antibody are lysed by added COMPLEMENT producing a clear zone of HEMOLYSIS. (From Illustrated Dictionary of Immunology, 3rd ed)
Blood Group Antigens
Heinz Bodies
Hematology
Cells, Cultured
Hemoglobin, Sickle
Neutrophils
Erythroid Precursor Cells
The cells in the erythroid series derived from MYELOID PROGENITOR CELLS or from the bi-potential MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS which eventually give rise to mature RED BLOOD CELLS. The erythroid progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E); BFU-E differentiate into CFU-E on stimulation by ERYTHROPOIETIN, and then further differentiate into ERYTHROBLASTS when stimulated by other factors.
Hemagglutination
Reticulocytes
Immature ERYTHROCYTES. In humans, these are ERYTHROID CELLS that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" (not the same as the ENDOPLASMIC RETICULUM), hence the name reticulocytes.
Erythroblasts
Oxygen
Bone Marrow Cells
Antibody Formation
ABO Blood-Group System
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
Models, Biological
Hemagglutination Tests
Blood Transfusion, Autologous
Tin Polyphosphates
Anemia, Hemolytic, Autoimmune
Spectrin
A high molecular weight (220-250 kDa) water-soluble protein which can be extracted from erythrocyte ghosts in low ionic strength buffers. The protein contains no lipids or carbohydrates, is the predominant species of peripheral erythrocyte membrane proteins, and exists as a fibrous coating on the inner, cytoplasmic surface of the membrane.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Potassium
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
Monocytes
Isoantibodies
Cell Differentiation
Anemia, Neonatal
Phenylhydrazines
Leukocyte Reduction Procedures
Membrane Proteins
Iron
beta-Thalassemia
A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.
Phagocytosis
Hemoglobinuria, Paroxysmal
A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
Malaria, Falciparum
Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
Cell Membrane Permeability
Blood Flow Velocity
Reference Values
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Sodium
Hematopoietic System
Dose-Response Relationship, Drug
Colony-Forming Units Assay
Venules
Liver
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Glucosephosphate Dehydrogenase Deficiency
Antigens, CD
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Coombs Test
A test to detect non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells.
Treatment Outcome
Hematopoietic Stem Cell Transplantation
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
Rabbits
Prospective Studies
Granulocyte Colony-Stimulating Factor
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Cell Lineage
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
Hydrogen-Ion Concentration
Leukemia
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
B-Lymphocytes
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
C-Reactive Protein
Dogs
Phenotype
Platelet Transfusion
Biological Transport
Immunoglobulin G
Chromium Isotopes
Horses
Folic Acid
Base Sequence
Phosphatidylserines
Erythroblastosis, Fetal
A condition characterized by the abnormal presence of ERYTHROBLASTS in the circulation of the FETUS or NEWBORNS. It is a disorder due to BLOOD GROUP INCOMPATIBILITY, such as the maternal alloimmunization by fetal antigen RH FACTORS leading to HEMOLYSIS of ERYTHROCYTES, hemolytic anemia (ANEMIA, HEMOLYTIC), general edema (HYDROPS FETALIS), and SEVERE JAUNDICE IN NEWBORN.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Exchange Transfusion, Whole Blood
Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.
Duffy Blood-Group System
Hemodilution
Bone Marrow Transplantation
Risk Factors
Elliptocytosis, Hereditary
Thalassemia
Oxyhemoglobins
Blood Group Incompatibility
An antigenic mismatch between donor and recipient blood. Antibodies present in the recipient's serum may be directed against antigens in the donor product. Such a mismatch may result in a transfusion reaction in which, for example, donor blood is hemolyzed. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984).
Leukapheresis
Pregnancy
Microscopy, Video
Blood
Amino Acid Sequence
Anemia, Macrocytic
Schizonts
Lutheran Blood-Group System
Microscopy, Electron, Scanning
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
Merozoites
Cord Blood Stem Cell Transplantation
Disease Models, Animal
Lab-On-A-Chip Devices
Microdevices that combine microfluidics technology with electrical and/or mechanical functions for analyzing very small fluid volumes. They consist of microchannels etched into substrates made of silicon, glass, or polymer using processes similar to photolithography. The test fluids in the channels can then interact with different elements such as electrodes, photodetectors, chemical sensors, pumps, and valves.
Inflammation
Isotope Labeling
Oxyquinoline
An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.
Sensitivity and Specificity
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Glutathione
Antigens, CD55
Microfluidics
Host-Parasite Interactions
Favism
alpha-Thalassemia
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Hematopoiesis, Extramedullary
Parasitemia
Oxidative Stress
Hemoglobin A
Urochordata
Mutation
Viscosity
Cell Count
Trout
Various fish of the family SALMONIDAE, usually smaller than salmon. They are mostly restricted to cool clear freshwater. Some are anadromous. They are highly regarded for their handsome colors, rich well-flavored flesh, and gameness as an angling fish. The genera Salvelinus, Salmo, and ONCORHYNCHUS have been introduced virtually throughout the world.
Blood Specimen Collection
DNA Adducts
Profound variation in dihydropyrimidine dehydrogenase activity in human blood cells: major implications for the detection of partly deficient patients. (1/1434)
Dihydropyrimidine dehydrogenase (DPD) is responsible for the breakdown of the widely used antineoplastic agent 5-fluorouracil (5FU), thereby limiting the efficacy of the therapy. To identify patients suffering from a complete or partial DPD deficiency, the activity of DPD is usually determined in peripheral blood mononuclear cells (PBM cells). In this study, we demonstrated that the highest activity of DPD was found in monocytes followed by that of lymphocytes, granulocytes and platelets, whereas no significant activity of DPD could be detected in erythrocytes. The activity of DPD in PBM cells proved to be intermediate compared with the DPD activity observed in monocytes and lymphocytes. The mean percentage of monocytes in the PBM cells obtained from cancer patients proved to be significantly higher than that observed in PBM cells obtained from healthy volunteers. Moreover, a profound positive correlation was observed between the DPD activity of PBM cells and the percentage of monocytes, thus introducing a large inter- and intrapatient variability in the activity of DPD and hindering the detection of patients with a partial DPD deficiency. (+info)Interaction of Borrelia burgdorferi with peripheral blood fibrocytes, antigen-presenting cells with the potential for connective tissue targeting. (2/1434)
BACKGROUND: Borrelia Burgdorferi has a predilection for collagenous tissue and can interact with fibronectin and cellular collagens. While the molecular mechanisms of how B. burgdorferi targets connective tissues and causes arthritis are not understood, the spirochetes can bind to a number of different cell types, including fibroblasts. A novel circulating fibroblast-like cell called the peripheral blood fibrocyte has recently been described. Fibrocytes express collagen types I and III as well as fibronectin. Besides playing a role in wound healing, fibrocytes have the potential to target to connective tissue and the functional capacity to recruit, activate, and present antigen to CD4(+) T cells. MATERIALS AND METHODS: Rhesus monkey fibrocytes were isolated and characterized by flow cytometry. B. burgdorferi were incubated with human or monkey fibrocyte cultures in vitro and the cellular interactions analyzed by light and electron microscopy. The two strains of B. burgdorferi studied included JD1, which is highly pathogenic for monkeys, and M297, which lacks the cell surface OspA and OspB proteins. RESULTS: In this study, we demonstrate that B. burgdorferi binds to both human and monkey (rhesus) fibrocytes in vitro. This process does not require OspA or OspB. In addition, the spirochetes are not phagocytosed but are taken into deep recesses of the cell membrane, a process that may protect them from the immune system. CONCLUSIONS: This interaction between B. burgdorferi and peripheral blood fibrocytes provides a potential explanation for the targeting of spirochetes to joint connective tissue and may contribute to the inflammatory process in Lyme arthritis. (+info)Quantification of T-cell progenitors during ontogeny: thymus colonization depends on blood delivery of progenitors. (3/1434)
An in vivo thymus reconstitution assay based on intrathymic injection of hematopoietic progenitors into irradiated chicks was used to determine the number of T-cell progenitors in peripheral blood, paraaortic foci, bone marrow (BM), and spleen during ontogeny. This study allowed us to analyze the regulation of thymus colonization occurring in three waves during embryogenesis. It confirmed that progenitors of the first wave of thymus colonization originate from the paraaortic foci, whereas progenitors of the second and the third waves originate from the BM. The analysis of the number of T-cell progenitors indicates that each wave of thymus colonization is correlated with a peak number of T-cell progenitors in peripheral blood, whereas they are almost absent during the periods defined as refractory for colonization. Moreover, injection of T-cell progenitors into the blood circulation showed that they homed into the thymus without delay during the refractory periods. Thus, thymus colonization kinetics depend mainly on the blood delivery of T-cell progenitors during embryogenesis. (+info)Expression of IkappaBalpha in the nucleus of human peripheral blood T lymphocytes. (4/1434)
According to current models the inhibitory capacity of I(kappa)B(alpha) would be mediated through the retention of Rel/NF-kappaB proteins in the cytosol. However, I(kappa)B(alpha) has also been detected in the nucleus of cell lines and when overexpressed by transient transfection. To gain better insight into the potential role of nuclear I(kappa)B(alpha) in a physiological context we have analysed its presence in the nucleus of human peripheral blood T lymphocytes (PBL). We demonstrate the nuclear localization of I(kappa)B(alpha) in PBL by different techniques: Western blot, indirect immunofluorescence and electron microscopy. Low levels of nuclear I(kappa)B(alpha) were detected in resting cells whereas a superinduction was obtained after PMA activation. The nuclear pool of I(kappa)B(alpha) showed a higher stability than cytosolic I(kappa)B(alpha) and was partially independent of the resynthesis of the protein. Unexpectedly, the presence of nuclear I(kappa)B(alpha) did not inhibit NF-kappaB binding to DNA and this phenomenon was not due to the presence of IkappaBbeta at the nuclear level. Immunoprecipitation experiments failed to demonstrate an association between nuclear I(kappa)B(alpha) and NF-kappaB proteins. Our results demonstrate that in resting and PMA-activated human PBL, I(kappa)B(alpha) is present in the nucleus in an apparently inactive form unable to disrupt NF-kappaB binding from DNA. (+info)Sensitive detection of squamous cells in bone marrow and blood of head and neck cancer patients by E48 reverse transcriptase-polymerase chain reaction. (5/1434)
In previous studies, we described the selective reactivity of monoclonal antibody E48 with normal squamous and transitional epithelia and their malignant counterparts and the capacity of monoclonal antibody E48 for selective tumor targeting in head and neck cancer patients. Cloning of the E48 encoding cDNA and elucidation of the gene structure enabled the selection of an intron-spanning primer set for the detection of circulating tumor cells in blood and bone marrow of head and neck cancer patients. Extensive optimizations led to a reproducible reverse transcriptase-PCR assay with an internal standard for RNA quality control and an external standard for sensitivity control. In reconstruction experiments, we were able to reach a reproducible sensitivity of one single tumor cell per 7 ml of blood (2 x 10(7) nucleated cells). When applying this method to patient material, we were able to detect positive signal in 35% of the bone marrow samples (0 of 2 stage II, 0 of 4 stage III, 4 of 11 stage IV, and 4 of 6 recurrences) and 10% of the blood samples (2 of 21) of patients with squamous cell carcinoma of the head and neck. The specificity of the method was demonstrated on 29 blood and bone marrow samples of noncancer controls, which were all negative. Our study shows the feasibility of E48 reverse transcriptase-PCR for the detection of squamous cells in nonsquamous tissues. (+info)Bacterial peptidoglycan polysaccharides in sterile human spleen induce proinflammatory cytokine production by human blood cells. (6/1434)
Peptidoglycan (PG) is the major component of the cell wall of gram-positive bacteria. In vitro, PG isolated from conventional bacterial cultures can induce secretion of proinflammatory cytokines by human monocytes, indicating that PG may be involved in immune responses against infections by gram-positive bacteria. To investigate the biologic activity of PG in human tissues, an improved method was developed to isolate significant amounts of PG from sterile human spleen tissue. Biochemical analysis demonstrated that PG isolated from human spleen is largely intact. Human whole blood cell cultures were able to produce the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1 and -6 after stimulation with PG isolated from human spleen. Cytokine induction was not sensitive to inhibition by polymyxin B, in contrast to lipopolysaccharide. Collectively, the data show that intact PG in sterile human tissue is biologically active and may induce local proinflammatory cytokine production. (+info)Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions. (7/1434)
The tetraspans are molecules with four transmembrane domains which are engaged in multimolecular complexes (the tetraspan web) containing a subset of beta1 integrins (in particular alpha3beta1, alpha4beta1 and alpha6beta1), MHC antigens and several unidentified molecules. The molecules associated with tetraspans are readily detected after immunoprecipitation performed in mild detergents such as Brij 97 or CHAPS. In this study we show that another classical mild detergent, digitonin, dissociated most of these associated molecules, including integrins, from the tetraspans CD9, CD37, CD53, CD63, CD82, Co-029, Talla-1 and NAG-2. In contrast, reciprocal immunoprecipitations from various cell lines demonstrated that two other tetraspans, CD81 and CD151, formed complexes with integrins not disrupted by digitonin. These complexes were CD81/alpha4beta1, CD151/alpha3beta1 and CD151/alpha6beta1. Furthermore, a new anti-CD151 monoclonal antibody (mAb), TS151r, was shown to have a restricted pattern of expression, inversely related to the sum of the levels of expression of alpha6beta1 and alpha3beta1. This mAb was unable to co-precipitate integrins in digitonin, suggesting that its epitope is blocked by the association with integrins. Indeed, the binding of TS151r to the cell surface was quantitatively diminished following alpha3beta1 overexpression. Altogether, these data suggest that, among tetraspans, CD81 interacts directly with the integrin alpha4beta1, and CD151 interacts directly with integrins alpha3beta1 and alpha6beta1. Because all tetraspan-tetraspan associations are disrupted by digitonin, it is likely that the other tetraspans interact indirectly with integrins, through interactions with CD81 or CD151. (+info)Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function. (8/1434)
The mouse NK1.1 Ag originally defined as NK cell receptor (NKR)-P1C (CD161) mediates NK cell activation. Here, we show that another member of the mouse CD161 family, NKR-P1B, represents a novel NK1.1 Ag. In contrast to NKR-P1C, which functions as an activating receptor, NKR-P1B inhibits NK cell activation. Association of NKR-P1B with Src homology 2-containing protein tyrosine phosphatase-1 provides a molecular mechanism for this inhibition. The existence of these two NK1.1 Ags with opposite functions suggests a potential role for NKR-P1 molecules, such as those of the Ly-49 gene family, in regulating NK cell function. (+info)
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NewYork-Presbyterian Queens - Overview of Blood and Blood Components
Overview of Blood and Blood Components
NewYork-Presbyterian Queens - High-Risk Newborn - Overview of Blood
Oldest Human Blood Cells Found in Prehistoric Caveman
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Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells. -...
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Human Blood Showing Red Blood Cells Sem Stockfoto | Getty Images
Sample Page
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Blood Cells Isolated stock photo | iStock
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White Blood Cells
"White Blood Cells - The White Stripes". AllMusic. Retrieved September 24, 2011. "The White Stripes: White Blood Cells". ... "The White Stripes: White Blood Cells". Q (181): 122. September 2001. Blashill, Pat (June 25, 2001). "White Blood Cells". ... White Blood Cells". Hung Medien. Retrieved June 16, 2016. "Lescharts.com - The White Stripes - White Blood Cells". Hung Medien ... White Blood Cells". Recording Industry Association of America. Wikiquote has quotations related to White Blood Cells. (All ...
Blood Cells (film)
"Blood Cells". Rotten Tomatoes. Maher, Kevin. "Blood Cells". Blood Cells at IMDb (Articles needing cleanup from September 2022, ... Blood Cells is a 2014 British drama film directed by Luke Seomore & Joseph Bull. The script was written by Luke Seomore, Joseph ... "Biennale College, Cinema - Blood Cells by Joseph Bull, Luke Seomore". labiennale.org. Archived from the original on 14 October ... "BLOOD CELLS , British Board of Film Classification". Archived from the original on 23 December 2016. Retrieved 22 December 2016 ...
Packed red blood cells
... , also known as packed cells, are red blood cells that have been separated for blood transfusion. The ... A number of other versions also exist including whole blood, leukocyte reduced red blood cells, and washed red blood cells. ... The other options is using the person's own blood. This is known as autologous blood transfusion. The person's red blood cells ... whole blood is collected from a blood donation and is spun in a centrifuge. The red blood cells are denser and settle to the ...
Washed red blood cells
... are red blood cells which have had most of the plasma, platelets and white blood cells removed and ... These proteins are removed by the process of washing the red blood cells. There are multiple methods of washing red cells. ... However, in neonates, there is insufficient evidence to say whether washing red cells has any effect. Once red blood cells have ... The allergen is usually a protein in the plasma that is removed by the process of washing the red blood cells. Various proteins ...
Blood Cells, Molecules and Diseases
... is a peer-reviewed medical journal covering hematology. It was established in 1975 as Blood ... "Blood Cells, Molecules & Diseases". NLM Catalog. National Center for Biotechnology Information. Retrieved 2015-01-05. "Journals ... "Blood Cells, Molecules and Diseases". Ulrichsweb. Retrieved 2015-01-07. "Master Journal List". Intellectual Property & Science ... Cells and obtained its current title in 1995. The editor-in-chief is Mohandus Narla. It is published eight times per year by ...
Blood cell
Red blood cells are the most abundant cell in the blood, accounting for about 40-45% of its volume. Red blood cells are ... Major types of blood cells include red blood cells (erythrocytes), white blood cells (leukocytes), and platelets (thrombocytes ... A blood cell, also called a hematopoietic cell, hemocyte, or hematocyte, is a cell produced through hematopoiesis and found ... The Discovery of Blood Cells". Ann Clin Lab Sci. 33 (2): 237-8. PMID 12817630. Media related to Blood cells at Wikimedia ...
White blood cell
The different white blood cells are usually classified by cell lineage (myeloid cells or lymphoid cells). White blood cells are ... All white blood cells have nuclei, which distinguishes them from the other blood cells, the anucleated red blood cells (RBCs) ... T cells: CD4+ helper T cells: T cells displaying co-receptor CD4 are known as CD4+ T cells. These cells have T-cell receptors ... Lymphoid cells (lymphocytes) include T cells (subdivided into helper T cells, memory T cells, cytotoxic T cells), B cells ( ...
Red blood cell
Nearly half of the blood's volume (40% to 45%) is red blood cells. Packed red blood cells (pRBC) are red blood cells that have ... Blood can be given as a whole product or the red blood cells separated as packed red blood cells. Blood is often transfused ... Several blood tests involve red blood cells. These include a RBC count (the number of red blood cells per volume of blood), ... Red blood cells are cells present in blood to transport oxygen. The only known vertebrates without red blood cells are the ...
The Blood Cell
"Doctor Who: The Blood Cell: A 12th Doctor Novel (Dr Who)". Amazon.co.uk. Retrieved 12 June 2016. The Blood Cell on Tardis Data ... "Review: Doctor Who: Books: The Blood Cell". Sci-Fi Bulletin. Retrieved 12 June 2016. Mount, Paul. "DOCTOR WHO - THE BLOOD CELL ... The Blood Cell is a BBC Books original novel written by James Goss and based on the long-running British science fiction ... The Blood Cell gained generally positive reviews, calling it an "effective chiller". Most of them commented the unusual way of ...
Red blood cell indices
... are blood tests that provide information about the hemoglobin content and size of red blood cells. ... per red blood cell and is calculated by dividing the hemoglobin by the red blood cell count.[citation needed] M C H = H b R B C ... is the average volume of a red blood cell and is calculated by dividing the hematocrit (Hct) by the concentration of red blood ... 32-36 g/dL Red blood cell distribution width (RDW or RDW-CV or RCDW and RDW-SD) is a measure of the range of variation of red ...
White blood cell differential
... and red blood cells containing abnormal hemoglobins (such as Hemoglobin S in sickle cell disease) as white blood cells, leading ... The white blood cell differential is a common blood test that is often ordered alongside a complete blood count. The test may ... Other cells Various other abnormal cells may be present in the blood in certain conditions. For example, lymphoma cells may be ... Before automated cell counters were introduced, cell counts were performed manually; white and red blood cells, and platelets ...
Peripheral blood mononuclear cell
... is any peripheral blood cell having a round nucleus. These cells consist of lymphocytes (T cells, B cells, NK cells) and ... and only a small percentage of dendritic cells. These cells can be extracted from whole blood or buffy coat samples using a ... Collection and processing of marrow and blood hematopoietic stem cells", Hematopoietic Stem Cell Transplantation in Clinical ... Peripheral blood cell Delves, Peter, et al. Roitt's Essential Immunology, 11th Ed. ISBN 978-1-4051-3603-7 The impact of food ...
Nucleated red blood cell
A nucleated red blood cell (NRBC), also known by several other names, is a red blood cell that contains a cell nucleus. Almost ... Blood cell lineage Hematopoiesis Erythropoiesis Haematopoiesis Hematopoietic stem cell Hartenstein, V (2006). "Blood cells and ... all of these red blood cells are nucleated. In mammals, NRBCs occur in normal development as precursors to mature red blood ... "Nucleated Red Blood Cell Counts"". Wintrobe's Clinical Hematology (14th ed.). Wolters Kluwer Health. ISBN 978-1-4963-6713-6. ...
Red blood cell distribution width
Red blood cells have an average volume of 80-100 femtoliters, but individual cell volumes vary even in healthy blood. Certain ... "High RDW level in the blood". MrLabTest. Last update: 12/01/2021 RDW Blood Test - Red Blood Cell Distribution Width (All ... is a measure of the range of variation of red blood cell (RBC) volume that is reported as part of a standard complete blood ... there will normally be a mix of both large cells and small cells, causing the RDW to be elevated. An elevated RDW (red blood ...
Blood plasma
... is a light amber-colored liquid component of blood in which blood cells are absent, but contains proteins and ... In addition, some tests have to be done with whole blood, such as the determination of the amount of blood cells in blood via ... Blood plasma and blood serum are often used in blood tests. Some tests can be done only on plasma and some only on serum. Some ... Blood plasma is separated from the blood by spinning a vessel of fresh blood containing an anticoagulant in a centrifuge until ...
Necrotaxis
An historical view". Blood Cells. 19 (1): 5-19. PMID 8400312. Ragot R. (1993). "Negative necrotaxis". Blood Cells. 19 (1): 81-8 ... Bessis, M. (1964). "Studies on cell agony and death: an attempt at classification.". In DeReuck, A.V.S.; Knight, J. (eds.). ... Model experiments of necrotaxis deal with special way of killing the target cells. For this purpose laser irradiation is used ... Investigations of necrotaxis proved that ability to sense substances released from dying cells is present in unicellular level ...
Endothelial colony forming cell
"Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells". Nat. ... "Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood". Blood. ... doi:10.1182/blood-2004-04-1396. PMID 15226175. Sedwick C (2012). "On the hunt for vascular endothelial stem cells". PLOS Biol. ... Baker CD, Balasubramaniam V, Mourani PM, Sontag MK, Black CP, Ryan SL, Abman SH (2012). "Cord blood angiogenic progenitor cells ...
Jean Bernard (physician)
Pavlovsky, A (1977). "[Jean Bernard and Argentinian hematology]". Nouvelle revue française d'hématologie; blood cells. 18 (2): ... blood cells. 18 (2): 441-4. PMID 335357. Gaertner, H (1976). "[Professor Jean Bernard elected member of the Académie Francaise ... Golliet, P; Binet J L (1983). "[2 blood historians, or response of Lucien Lévy-Bruhl and Wifredo Lam to Jean Bernard]". ...
Erythrocyte aggregation
... is the reversible clumping of red blood cells (RBCs) under low shear forces or at stasis. Erythrocytes ... Cabel M, Meiselman HJ, Popel AS, Johnson PC (1997). "Contribution of red blood cell aggregation to venous vascular resistance ... Mesielman HJ (1993). "Red blood cell role in RBC aggregation: 1963-1993 and beyond". Clinical Hemorheology. 13: 575-592. Neu B ... Meiselman HJ (2009). "Red blood cell aggregation: 45 years being curious". Biorheology. 46 (1): 1-19. doi:10.3233/BIR-2009-0522 ...
Orders of magnitude (length)
... diameter of the nucleus of a typical eukaryotic cell[citation needed] about 7 μm - diameter of human red blood cells 3-8 μm - ... mean width of quartz unit cell 820 pm - mean width of ice unit cell 900 pm - mean width of coesite unit cell The nanometre (SI ... "Blood cells". biosbcc.net. Archived from the original on 23 July 2016. Retrieved 19 July 2016. According to The Physics ... mean longest dimension of a human red blood cell[citation needed] 5-20 μm - dust mite excreta 10.6 μm - wavelength of light ...
Mean platelet volume
Blood Cells. 11 (1): 127-35. PMID 4074887. "High MPV level in the blood". MrLabTest.com. 30 March 2021. v t e (Articles needing ... "CBC (Complete Blood Count), Blood". www.healthcare.uiowa.edu. Retrieved 2018-02-22. "Paris-Trousseau syndrome". MrLabTest. ... is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as ... Blood Transfusion: 1-9. doi:10.1007/s12288-021-01411-2. PMC 7988247. PMID 33776267. Gao Y, Li Y, Yu X, Guo S, Ji X, Sun T, et ...
Mitochondrial ferritin
2002). "Mitochondrial ferritin: a new player in iron metabolism". Blood Cells Mol. Dis. 29 (3): 376-83. doi:10.1006/bcmd. ... 2003). "Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia". Blood. 101 (5): 1996- ... Cell Biol. 40 (10): 2110-9. doi:10.1016/j.biocel.2008.02.010. hdl:10447/35800. PMID 18372207. Snyder AM, Wang X, Patton SM, et ... Cell. Biol. 26 (7): 2845-56. doi:10.1128/MCB.26.7.2845-2856.2006. PMC 1430308. PMID 16537925. Hasan MR, Tosha T, Theil EC (2008 ...
Hepcidin
This typically leads to anemia due to an inadequate amount of serum iron being available for developing red blood cells. When ... Moura IC, Hermine O (2015). "Erythroferrone: the missing link in β-thalassemia?". Blood. 126 (17): 1974-5. doi:10.1182/blood- ... Blood Cells Mol. Dis. 40 (1): 132-8. doi:10.1016/j.bcmd.2007.07.009. PMC 2211381. PMID 17905609. Pandur E, Nagy J, Poór VS, ... Blood. 106 (12): 3710-7. doi:10.1182/blood-2005-05-1857. PMID 16030190. hepcidin at the US National Library of Medicine Medical ...
GBA3
2010). "The cytosolic beta-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation". Blood Cells Mol. Dis. 46 ... 2003). "Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and ...
Dexpramipexole
March 2017). "The targeted eosinophil-lowering effects of dexpramipexole in clinical studies". Blood Cells Mol. Dis. 2017 Mar: ... Gleich, Gerald (August 2018). "Dexpramipexole: a new antieosinophil drug?". Blood. 132 (5): 461-462. doi:10.1182/blood-2018-06- ... doi:10.1182/blood-2018-02-835330. PMC 6073324. PMID 29739754. Laidlaw, Tanya; et al. (February 2019). "Dexpramipexole depletes ... May 17, 2021). "Oral Dexpramipexole Efficacy in Lowering Blood Eosinophils in Patients with Moderate to Severe Uncontrolled ...
Neutrophil cytosolic factor 4
Matute JD, Arias AA, Dinauer MC, Patiño PJ (2006). "p40phox: the last NADPH oxidase subunit". Blood Cells Mol. Dis. 35 (2): 291 ... Blood. 88 (7): 2714-21. doi:10.1182/blood.V88.7.2714.bloodjournal8872714. PMID 8839867. "Entrez Gene: NCF4 neutrophil cytosolic ... Grandvaux N, Grizot S, Vignais PV, Dagher MC (1999). "The Ku70 autoantigen interacts with p40phox in B lymphocytes". J. Cell ... This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 ...
Triosephosphate isomerase deficiency
Tightly linked polymorphisms and a common haplotype in all known families". Blood Cells Mol. Dis. 22 (2): 115-25. doi:10.1006/ ...
Chloride potassium symporter 4
Blood Cells Mol. Dis. 24 (1): 31-40. doi:10.1006/bcmd.1998.0168. PMID 9516379. Su W, Shmukler BE, Chernova MN, et al. (1999). " ... 2005). "Oxygen dependence of K+-Cl− cotransport in human red cell ghosts and sickle cells". Bioelectrochemistry. 62 (2): 141-6 ... Blood. 103 (11): 4302-9. doi:10.1182/blood-2003-01-0107. PMID 14976052. Khan AI, Drew C, Ball SE, et al. ( ... J. Physiol., Cell Physiol. 285 (1): C22-30. doi:10.1152/ajpcell.00289.2002. PMID 12637262. Shen MR, Chou CY, Hsu KF, et al. ( ...
Pyruvate kinase PKLR
Baronciani L, Bianchi P, Zanella A (1996). "Hematologically important mutations: red cell pyruvate kinase". Blood Cells Mol. ... Baronciani L, Bianchi P, Zanella A (1999). "Hematologically important mutations: red cell pyruvate kinase (2nd update)". Blood ... 1994). "Molecular abnormality of erythrocyte pyruvate kinase deficiency in the Amish". Blood. 83 (8): 2311-6. doi:10.1182/blood ... Blood. 77 (9): 1871-5. doi:10.1182/blood.V77.9.1871.1871. PMID 2018831. Tani K, Fujii H, Nagata S, Miwa S (1988). "Human liver ...
Roland Mertelsmann
In: Blood Cells. 1982;8(3), S. 561-583. PMID 6984348 R. Mertelsmann, H. Tzvi Thaler, L. To, T. S. Gee, S. McKenzie, P. Schauer ... In: Blood. 2013 Jan 3;121(1), S. 239-241. doi:10.1182/blood-2012-09-454439. PMID 23287626 C. Dierks, J. Grbic, K. Zirlik, R. ... h.c. Roland Mertelsmann R. Mertelsmann: Plasticity of bone marrow-derived stem cells. In: J Hematother Stem Cell Res. 2000 Dec; ... The "Plasticity" of hematopoietic stem cells (HSC), i.e. the differentiation of HSC into cells of other organs, was intensively ...
Ariosa v. Sequenom
6,258,540, which claims methods of using cell-free fetal DNA (cffDNA) circulating in maternal plasma (cell-free blood) to ... but had traveled from the fetal blood into the maternal blood through the placenta. The paternal DNA in the mother's plasma had ... not just in the blood of the fetus, which was accessible only by invasive methods, such as amniocentesis, that created risks of ... and that paternal DNA was not native to the mother's blood. So they wanted to focus on genetic fragments containing paternally ...
Atrioventricular node
Contraction of heart muscle cells requires depolarization and repolarization of their cell membranes. Movement of ions across ... The blood supply of the AV node is from the atrioventricular nodal branch. The origin of this artery is most commonly (80-90% ... In right-dominant individuals the blood supply is from the right coronary artery while in left dominant individuals it ... Pejković, B.; Krajnc, I.; Anderhuber, F.; Kosutić, D. (2008). "Anatomical aspects of the arterial blood supply to the ...
Mycoplasma incognitus
It is known that the most frequently colonized sites are epithelial cell surfaces and red and white blood cells inside of the ... M. incognitus has the ability to alter red blood cells so that they swell and therefore cannot be compressed and passed through ... Since M. incognitus is a mycoplasma, it does not have a cell wall, which means that it is naturally immune to many different ... This mycoplasma acts by entering into the individual cells of the body where it can lie dormant for 10, 20, or 30 years. If the ...
Hemoencephalography
While the skull is largely translucent to these wavelengths of light, blood is not. The red light is used as a probe, while the ... Photoelectric cells in a spectrophotometer device worn on the forehead measure the amount of each wavelength of light reflected ... To keep up with the nutritional and waste removal demands of a higher metabolic rate, cerebral blood flow to the cortical area ... In contrast, the amount of infrared light scattered by the blood is largely impermeable to changes in the oxygenation level of ...
Ziziphus
It is believed to nourish the heart yin, augment the liver blood, and calm the spirit (TCM medical terms). It is used to treat ... Species in less humid environment are smaller or less robust, with less abundant and thinner foliage and have oleifera cells ...
Occupation of the Malheur National Wildlife Refuge
Other cell phone video footage shot by Ryan Bundy, another passenger, also showed Finicum taunting officers and daring them to ... Finicum, LaVoy (2015). Only by Blood and Suffering: Regaining Lost Freedom. Rochester, NY: Legends Library Publishing, Inc. ... "Ryan Bundy's cell phone video of moments before and after Finicum shooting released". Portland, Oregon: KATU. April 5, 2016. ... Shawna Cox, a passenger in Finicum's truck, recorded cell phone video of Finicum shouting to police that he intended to ignore ...
Prostaglandin-endoperoxide synthase 2
Cell Dev. Biol. 17 (5): 544-54. doi:10.1016/j.semcdb.2006.09.001. PMID 17071117. Minghetti L, Pocchiari M (2007). " ... particularly prostacyclin which is found in blood vessel lining. Prostacyclin relaxes or unsticks platelets, so selective COX-2 ... PTGS2 (COX-2) is unexpressed under normal conditions in most cells, but elevated levels are found during inflammation. PTGS1 ( ... Since PTGS2 (COX-2) is generally expressed only in cells where prostaglandins are upregulated (e.g., during inflammation), drug ...
Norovirus
Tan M, Hegde RS, Jiang X (2004). "The P Domain of Norovirus Capsid Protein Forms Dimer and Binds to Histo-Blood Group Antigen ... FUT2 fucosyltransferase transfers a fucose sugar to the end of the ABO(H) precursor in gastrointestinal cells and saliva glands ... Reports have shown a link between the expression of human histo-blood group antigens (HBGAs) and the susceptibility to ... Entry into the host cell is achieved by attachment to host receptors, which mediates endocytosis. Positive-stranded RNA virus ...
Carlos the Jackal
During his trial in France in 1997, he said, "When one wages war for 30 years, there is a lot of blood spilled-mine and others ... In June 2003, Carlos published a collection of writings from his jail cell. The book, whose title translates as Revolutionary ... a supporter of the imprisoned Red Army Faction and a member of the Revolutionary Cells, and Gabriele Kröcher-Tiedemann, from ... Venezuelan president Hugo Chávez had a sporadic correspondence with Carlos from the latter's prison cell in France. Chávez sent ...
Proto-oncogene tyrosine-protein kinase Src
Lyn and Fgr are highly expressed in malignant prostate cells compared to normal prostate cells. When the primary prostate cells ... Blood Cancer J. 3 (11): 61. doi:10.1038/s41408-021-00450-2. PMC 7973815. PMID 33737511. src+Gene at the US National Library of ... HSP90 inhibitor NVP-BEP800 has been described to affect stability of Src tyrosine kinase and growth of T-cell and B-cell acute ... Src, Fyn and Yes are expressed ubiquitously in all cell types while the others are generally found in hematopoietic cells. c- ...
Biliblanket
... since they are replacing and breaking down more red blood cells at a higher rate) and babies who have a blood group that is not ... Bilirubin is an orange yellow bile pigment that is produced as a byproduct of hemoglobin as red blood cells break down ( ... Nevertheless, when bilirubin levels become exceedingly high, the substance may move out of the blood, cross the blood brain ... Blood tests may be required daily during phototherapy to assess the bilirubin levels and determine if normal levels have been ...
Media
... the middle layer of the wall of a blood vessel Media, Illinois Media, Kansas Media, Pennsylvania Media (castra), a fort in the ... objects in which microorganisms or cells can experience growth Media filter, a filter consisting of several different filter ...
Robot research initiative
Stem Cell-based Biomedical Microrobot: Mesenchymal stem cell delivery scaffold with magnetic actuating system for articular ... Intravascular therapeutic Microbot Lab - Microrobot moving controlled through blood vessel for drug delivery and treatment of ... With size of 200~300 um, it is the world's first stem cell based microrobot. It was developed in 2017 and transferred and ...
Bohemic acid
Furthermore, the antitumor pharmacokinetics of marcellomycin in the human blood has been evaluated both in vitro and in vivo. ... Daskal, Y; Woodard, C; Crooke, ST; Busch, H (1978). "Comparative Ultrastructural Studies of Nucleoli of Tumor Cells Treated ...
Çayönü
Middle PPNB cell, Late PPNB large room, final PPNB An analysis of blood found at the site suggested that human sacrifice ... Loy, Thomas H.; Wood, Andrée R. (1989). "Blood Residue Analysis at Çayönü Tepesi, Turkey". Journal of Field Archaeology. 16 (4 ...
Euchambersia
... or alternatively a ganglion of nerve cells. It is also possible that this organ functioned as a replacement for the parietal ... would primarily have supported the trigeminal nerve as well as blood vessels. However, the fact that the canals also directly ...
Choriogenesis
April 1993). "Induction of choriogenesis by 20-hydroxyecdysone in the German cockroach". Tissue & Cell. 25 (2): 195-204. doi: ... an outer membrane of the placenta that eventually forms chorionic villi that allow the transfer of blood and nutrients from ...
Brain ischemia
Sickle cell anemia may cause brain ischemia associated with the irregularly shaped blood cells. Sickle shaped blood cells clot ... Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood ... Untreated heart attacks may slow blood flow enough that blood may start to clot and prevent the flow of blood to the brain or ... more easily than normal blood cells, impeding blood flow to the brain.[citation needed] Compression of blood vessels may also ...
Strømme syndrome
Most cilia are primary cilia, which are involved in cell signalling, sending and receiving signals to trigger cell migration, ... Platelets are cellular fragments formed from protrusions on megakaryocytes that enable blood clotting. Blood symptoms have not ... They also aid in cell migratory ability. They are made by the centrosome, which contains a pair of cylindrical centrioles at ... Mutations in this gene lead to impaired cell division during early development. Mitosis has been found to take longer when ...
Kherson
Stefania Berlinerblau (1852-1921) American anatomist and physician, investigated blood circulation Maximilian Bern (1849-1923) ... underground cells. The Kherson district leadership of the OUN was headed by Bogdan Bandera (brother of OUN leader Stepan ...
Caspase-activated DNase
"Heat shock protein 70 binds caspase-activated DNase and enhances its activity in TCR-stimulated T cells". Blood. 102 (5): 1788- ... Apoptosis is a cell self-destruct process that removes toxic and/or useless cells during mammalian development and other life ... The cell diversity is originated by cell differentiation, which has been attributed to the activation of specific transcription ... Despite this gene being present in every cell, this protein is only expressed in different tissues and cell variety such as ...
Job interview
Items like cell phones, a cup of coffee, and chewing gum are not recommended to bring to an interview, as it can lead to the ... behavior because it would evoke hostility and even changes in blood pressure and heart rate in study subjects. The key to ...
Candida blankii
Blood sample DNA sequencing of the 26S ribosomal subunit can definitively identify C. blankii. In nature, Candida blankii forms ... A diploid isolate of C. blankii had an observed "potential for use in single cell protein production from hemicellulose ... Fungal blood-stream infections (fungaemia) have been newly associated with C blankii. Polyene antifungals have been identified ...
Desmond Miles
While searching for the power cells in Manhattan and São Paulo, Desmond is hunted by the Templar Daniel Cross, dispatched by ... Because Abstergo can now collect anyone's genetic memories without having to use blood-related analysts, Desmond's body gives ... After finding the Key and all the power cells, Desmond and his allies enter the Central Vault, whereupon Minerva and Juno ... After William is captured while trying to recover the last power cell, Desmond storms Abstergo's facility in Rome, kills Cross ...
Charleston church shooting
At the jail, his cell-block neighbor was Michael Slager, the former North Charleston police officer charged with murder after ... The Rabbinical Assembly, in its own statement, quoted Leviticus, saying, "'Do not stand idly by the blood of your neighbor.' ... Drash, Wayne (December 17, 2015). "Inside the Bible Study Massacre: A mom 'laid in her son's blood'". CNN. Retrieved October 13 ...
Papillary carcinomas of the breast
PCB develop from the epithelial cells that line the outer surfaces of ducts leading from exocrine glands or organs, blood ... These cells, which are not myoepithelial cells, have been termed globoid cells. They have eosinophilic cytoplasm (i.e. pink or ... Epithelial cells lining the fronds' inner surfaces commonly form solid, cribriform (i.e. large nests of cells perforated by ... Mucin may also occur outside of cells in these lesions. The presence of signet ring-shaped cells bearing mucin-containing ...
CKLF-like MARVEL transmembrane domain-containing 5
... regulate the function of immunologically active blood cells (and, perhaps, blood platelets) and thereby the development, ... Preliminary studies suggest that CMTM5-v1 (which cells commonly secrete to the extracellular spaces such as the blood) or an ... The forced over expression of CMTM5-v1 in Huh7 human hepatic cells also inhibited the ability of these cells to grow in a mouse ... Cai B, Xiao Y, Li Y, Zheng S (August 2017). "CMTM5 inhibits renal cancer cell growth through inducing cell-cycle arrest and ...
Zdzisław Najmrodzki
On 19 November 1989 in Kraków, while drunk with 0.21 BAC of alcohol in his blood, Najmrodzki crashed a Polski Fiat 132p he had ... He left a letter addressed to the warden in his cell, thanking him for his hospitality. ...
Multiple system atrophy
Mesenchymal stem cell therapy may delay the progression of neurological deficits in patients with MSA-cerebellar type. Ronald ... Avoidance of triggers of low blood pressure, such as hot weather, alcohol, and dehydration, are crucial. The patient can be ... Multiple system atrophy can be explained as cell loss and gliosis or a proliferation of astrocytes in damaged areas of the ... Hass EW, Sorrentino ZA, Xia Y, Lloyd GM, Trojanowski JQ, Prokop S, Giasson BI (August 2021). "Disease-, region- and cell type ...
Papillary tumors of the pineal region
These cells have proteins that make up the characteristics of the tumor. These proteins arise from blood vessels, nerve cells ... Vacuolated, or clear cells are common. Necrosis or cell death is normally observed to some extent in most of these tumors cells ... Pineal region tumors are normally composed of a variety of cells including astrocytes, ganglion cells, blood vessels, and ... If the abnormal cells continue to grow, divide, and produce more abnormal cells, the mass of abnormal cells may eventually ...
Blood cells: MedlinePlus Medical Encyclopedia Image
Browsing Regional Committee for Africa by Subject "Blood Cells"
Sickle-cell disease is a genetic blood disorder that affects the haemoglobin within the redblood cells. The recurrent pain and ... Browsing Regional Committee for Africa by Subject "Blood Cells". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. ... Sickle-Cell Disease in the African Region: Current Situation and the Way Forward Report of the Regional Director  ...
Quantitation of Cell-Derived Microparticles in Blood Products
Should blood products be routinely screened for cell-derived microparticles? This article discusses how such data could be ... Quantitation of Cell-Derived Microparticles in Blood Products and Its Potential Applications in Transfusion Laboratories. ... Cell-derived microparticles (MPs) are small fragments released from various cells when they are activated or undergo apoptosis ... Evaluating performance of blood product preparation instrument and processing. • Monitoring MP levels in stored blood products ...
Blood Cells
All about Blood Cells. Red Blood Cell. Red blood cells, or erythrocytes, contain the hemoglobin that carries oxygen and carbon ... Blood Cells themed gift box includes these mini microbes: Red Blood Cell, White Blood Cell, Plasma, Platelet, and Antibody.. ... Blood Cells. You wont faint at the sight of these adorable Blood Cells. Replace your hemophobia and learn to love your plasma ... White Blood Cell. White blood cells, or Leukocytes, are your bodys white knights. If an enemy germ invades you, they ride to ...
Fake Blood | Cells Album Review | Contactmusic.com
Review of Cells Album by Fake Blood. Remember The Wiseguys? You should. Their single Ooh La La soundtracked a Budweiser ... Instead, Keating sticks to his guns and the origins of Fake Blood throughout Cells. Lengthy in parts, which sometimes has an ... Fake Blood - Cells Album Review. By Dom Gourlay on 04 January 2013 ... Which is where his current alter ego Fake Blood comes in. Having adopted the moniker five years ago, more as an alias for a ...
Blood cell disguise halts multiple sclerosis | New Scientist
Disguising myelin as a red blood cell stops the immune system from treating it as a foreign invader, halting the debilitating ... The nanoparticles are consumed by another type of immune cell - macrophages - that mistake them for harmless dying red blood ... In MS, immune cells called T-cells treat myelin - which insulates nerves - as a foreign invader and destroy it. This disrupts ... cells. The team thinks the macrophages then send a message to the rest of the immune system that this particle, along with its ...
High blood sugar levels 'reprogramme' stem cells | University of Oxford
They removed the white blood cells from blood samples and grew them in an environment with normal glucose levels. Those from ... alters stem cells in the bone marrow that go on to become white blood cells called macrophages. As a result, these macrophages ... High blood sugar levels reprogramme stem cells. ResearchHealth. Findings explain higher risk of heart attack in people with ... High levels of glucose in the blood reprogrammes stem cells, leading to a lasting increase in the risk of developing ...
Blood Cell Tracking
... on WN Network delivers the latest Videos and Editable pages for News & Events, including Entertainment, ... Blood cell. A blood cell, also called a haematopoietic cell, hemocyte, or hematocyte, is a cell produced through hematopoiesis ... Red blood cells (Erythrocytes). Red blood cells primarily carry oxygen and collect carbon dioxide through the use of ... Together, these three kinds of blood cells add up to a total 45% of the blood tissue by volume, with the remaining 55% of the ...
Pre-Clinical Evaluation of Red Blood Cells for Transfusion Public Workshop
Session 5 - Potential Mechanisms of Red Blood Cell Transfusion Associated Toxicity. (Focus: How does red blood cell quality ... Hematopoietic Progenitor Cell, Apheresis and Marrow Donor History Questionnaire * Hematopoietic Progenitor Cell, Cord Blood ... Red Blood Cells as Transfusion Products. (Focus: State of the science overview of assessing quality and efficacy of red blood ... Blood Epidemiology and Clinical Therapeutics Branch Division of Blood Diseases and Resources National Heart, Lung, and Blood ...
Browsing by Subject "Blood Cells"
Sickle-cell disease is a genetic blood disorder that affects the haemoglobin within the redblood cells. The recurrent pain and ... Sickle-Cell Disease in the African Region: Current Situation and the Way Forward Report of the Regional Director  ... Status of blood safety in the WHO African Region: report of the 2006 Survey  ...
Laser Destroys Cancer Cells Circulating in the Blood - IEEE Spectrum
Laser Destroys Cancer Cells Circulating in the Blood The first study of a new treatment in humans demonstrates a noninvasive, ... Their wrist-worn device pumps blood out of the body, captures CTCs, and then pumps the cleansed blood back into the body. Still ... Heat from the laser causes vapor bubbles to form on the tumor cells. The bubbles expand and collapse, interacting with the cell ... Zharovs device can examine a liter of blood in about an hour, without the blood ever leaving the body. Its sensitivity is ...
People who've had COVID-19 show promising disease-fighting cells in their blood
A report published May 14 in the journal Cell offers some encouraging signs about how our immune systems respond to SARS-CoV-2 ... All the blood donors carried "helper" T cells, which rouse the immune system and assist antibody-producing immune cells. About ... Researchers observed that people who recover from COVID-19 carry immune cells in their blood called T cells that target the ... Importantly, they observed that people who recover from COVID-19 carry immune cells in their blood called T cells that target ...
Stream Of Blood Cells Stock Image - Royalty Free Image ID 100261839
Stock Image of Stream Of Blood Cells (Image ID 100261839). Royalty free stock image for instant download. ... HomeHealth and beautyHuman bodyStream Of Blood Cells. Stream Of Blood Cells Stock Photo. Photo by tigger11th. Published on 20 ... blood, cell, red, stream, hemoglobin, human, threedimensional, biological, biology, body, science, anatomy, 3d ... This royalty free image, "Stream Of Blood Cells", can be used in business, personal, charitable and educational design projects ...
Segregation analysis of human red blood cell thiopurine methyltransferase activity
High Blood Pressure? You Might Be Missing Key Cells
If you have high blood pressure, youve probably always blamed it on those few extra pounds or all that bacon you indulge in- ... Basically, the cells reside in part of the brain that helps regulate involuntary functions including blood pressure, and mice ... Scientists in Sweden discovered a group of nerve cells in the brains of mice that affect blood pressure as well as other ... If you have high blood pressure, youve probably always blamed it on those few extra pounds or all that bacon you indulge in- ...
Cord Blood Cells Foretell Food Allergy | The Scientist Magazine®
Cord Blood Cells Foretell Food Allergy. Scientists link an immune phenotype present at birth to the development of food ... and larger ratios of CD14+ monocytes to CD4+ T cells-two populations of immune cells that are inversely related in cord blood. ... and his colleagues examined the composition of immune cells in the cord blood of newborns enrolled in the Barwon Infant Study ( ... Whatever the cause, Berin said a cord blood-based test could be a useful predictor of which children are most at risk of ...
Red Blood Cell Physiology
... , Hemoglobin Production, Hemoglobin A2, Hemoglobin A, Hemoglobin F, Hemoglobin H, Hemoglobin Bart. ... Red Blood Cell Physiology. Red Blood Cell Physiology Aka: Red Blood Cell Physiology, Hemoglobin Production, Hemoglobin A2, ... Red Blood Cells start as Reticulocytes in Bone Marrow. *Reticulocytes are juvenile Red Blood Cells. *Nucleus extruded once RBC ... These images are a random sampling from a Bing search on the term "Red Blood Cell Physiology." Click on the image (or right ...
Cluster size distribution of cancer cells in blood using stopped-flow centrifugation along scale-matched gaps of a radially...
... defined here as cells or clusters thereof) in a blood sample. After off-chip removal of red blood cells, healthy white blood ... Tumor cells circulating in the blood are an excellent indicator for the prognosis of various cancers. In particular, the ... Simultaneous isolation and quantification of individual cells and cell clusters is possible thanks to a centrifugal ... cells using identical protocols and reagents. The propensity to form clusters was quantified for a number of cell lines, ...
Finding cancer cells in blood
Red blood cells and the majority of blood cells pass through the filter; tumor cells are larger and are trapped. They can be ... as low as one to ten cells per milliliter of blood-in the presence of large numbers of red blood cells and other cells. ... Finding cancer cells in blood. (Nanowerk News) Even in the early stages of cancer, individual cancer cells can be found in the ... Enrichment of cells: An approach called ensemble-decision aliquot ranking (eDAR) for isolating rare cells from peripheral blood ...
3D Blood Vessel Map Reveals Location of Stem Cells | Medgadget
3D Blood Vessel Map Reveals Location of Stem Cells. November 23rd, 2021 Conn Hastings Genetics, Medicine, Orthopedic Surgery, ... Understanding the distribution of specific cell types and blood vessels within our body is no easy task, and detailed maps are ... "We need to see whats happening inside the skull, including the relative locations of blood vessels and cells and how their ... To begin, the team used immunofluorescent stains to label specific cell types and blood vessels with identifying tags. They ...
Blood Biomarkers in Drug-Resistant Prostate Cancer Tumor Cells Identified
Blood markers associated with prostate tumor resistance to two common hormone therapies have been discovered by Duke Cancer ... "We have developed a method that allows us to examine the whole genome of rare circulating cancer cells in the blood, which is ... Blood Biomarkers in Drug-Resistant Prostate Cancer Tumor Cells Identified Personalised Printable Document (PDF). Please ... demonstrated that circulating tumor cells detected in blood have the potential to reveal important genetic information that ...
Frontiers in Physiology | Red Blood Cell Physiology
Advances our understanding of red blood cells considering increasingly complex approaches and new technological developments ... Advances our understanding of red blood cells considering increasingly complex approaches and new technological developments ... Storage of packed red blood cells impairs an inherent coagulation property of erythrocytes. in Red Blood Cell Physiology ... ERK1/2 phosphorylation and reactive oxidizing species in red blood cells from patients with Rheumatoid Arthritis. in Red Blood ...
Cell Lines and Blood Products | Fisher Scientific
Browse a full range of Cell Lines and Blood Products products from leading suppliers. Shop now at Fisher Scientific for all of ... Cell Lines and Blood Products. Cell Lines and Blood Products. Human- and animal-derived blood, blood products, cells, and cell ... culture enhancing reagents suitable for a variety of cell culture experiments and procedures. ...
Human Peripheral Blood CD4+CD45RO+ T Cells, Frozen | STEMCELL Technologies
Cells were obtained using Institutional Review Board (IRB)-approved consent forms and protocols. Certain produc ... Peripheral blood primary memory CD4+ T Cells are isolated by negative separation techniques based on the expression of both CD4 ... Primary human CD4+CD45RO+ T cells were isolated from peripheral blood (PB) mononuclear cells (MNCs) using negative ... CD4 and CD45RO are co-expressed on memory CD4+ T cells.. Cells were obtained using Institutional Review Board (IRB)-approved ...
TO YOUR GOOD HEALTH: Thrombocythemia is too many clotting cells in the blood
blood cells Archives - Online Cancer Blog
White blood cells - Cancer Survivors Network
White Blood Cell 3D Models for Download | TurboSquid
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PlateletsMononuclear cellsVesselsTransfusionsDonorsBone2022HemoglobinGeneticAntibodiesOxygenPlateletNeutrophilsPeople with sickle cellTumorSerumDonorMiceImmune cellsPeripheral Blood Stem CellLeukocytesAnemiaProteinsSymptoms of Sickle Cell DiImmature cellsCancersEndothelial cellsInflammatoryInfectionBody'sLeukocyteRBCsClotsClinicalDisorderBacteriaResearchersHematopoietic stemCord bloodMarrowSurvivalGlucoseAllogeneicDisordersTypesAntibodyCancerFlow cytometryLeukemiaWhite BlooDetectCTCsTransplantationMicroliterTransfusion medicineHaematopoietic
Platelets11
- Blood is comprised of red blood cells, platelets, and various white blood cells. (medlineplus.gov)
- Replace your hemophobia and learn to love your plasma, platelets and all the wonderful cells pulsing through your veins. (giantmicrobes.com)
- Platelets, or thrombocytes, are the smallest cells (or cell fragments) in the blood. (giantmicrobes.com)
- The primary purpose of platelets is to prevent bleeding by creating blood clots, and the average person has between 150,000 to 400,000 platelets in every drop (or microliter) of blood. (giantmicrobes.com)
- Those immature cells then divide again, mature even more, and ultimately become red blood cells, white blood cells, or platelets. (merckvetmanual.com)
- Leukemia may affect red blood cells, white blood cells, and platelets. (cancer.gov)
- Red marrow contains blood stem cells that can become red blood cells, white blood cells, or platelets. (cancer.gov)
- Platelets that form blood clots to stop bleeding. (cancer.gov)
- Sometimes in AML, too many stem cells become abnormal red blood cells or platelets. (cancer.gov)
- These abnormal white blood cells, red blood cells, or platelets are also called leukemia cells or blasts. (cancer.gov)
- Leukemia cells can build up in the bone marrow and blood so there is less room for healthy white blood cells, red blood cells, and platelets. (cancer.gov)
Mononuclear cells7
- Primary human CD4+CD45RO+ T cells were isolated from peripheral blood (PB) mononuclear cells (MNCs) using negative immunomagnetic separation techniques. (stemcell.com)
- To find drugs suitable for repositioning for use against leukemia, samples from patients with chronic lymphocytic, acute myeloid and lymphocytic leukemias as well as peripheral blood mononuclear cells (PBMC) were tested in response to 1266 compounds from the LOPAC 1280 library (Sigma). (nature.com)
- In the present study 12 samples of leukemia and 4 samples of normal mononuclear cells were tested in response to 1266 mechanistically annotated compounds including Food and Drug Administration-approved drugs. (nature.com)
- Quinacrine was the only compound found with activity in the three leukemia subtypes tested with concurrent low toxicity in normal mononuclear cells, and was, therefore, selected for further preclinical evaluation. (nature.com)
- Twelve samples of leukemia (four acute lymphocytic leukemia, four acute myeloid leukemia (AML), four chronic lymphocytic leukemia), as well as peripheral blood mononuclear cells (PBMC) from four healthy donors were used for the compound screen. (nature.com)
- The aim of this study was to identify gene expression profiles in peripheral blood mononuclear cells (PBMCs) from sporadic amyotrophic lateral sclerosis (sALS) patients to gain insights into the pathogenesis of ALS. (nih.gov)
- Neonatal porcine islet transplanted NOD-SCID IL2rγ −/− mice received human peripheral blood mononuclear cells (PBMC) with in vitro expanded autologous Treg in the absence or presence of anti-human interleukin-10 (IL-10) monoclonal antibody. (diabetesjournals.org)
Vessels27
- The other blood components are suspended in plasma, and it allows them to travel through the blood vessels and around your body! (giantmicrobes.com)
- Scientists at Johns Hopkins used a combination of molecular labeling and imaging techniques to create a three-dimensional map of the blood vessels in the mouse skull. (medgadget.com)
- Their approach also reveals niches where stem cell populations lurk, which could help researchers to understand how blood vessels and cells behave in various states of disease or injury. (medgadget.com)
- Understanding the distribution of specific cell types and blood vessels within our body is no easy task, and detailed maps are hard to come by. (medgadget.com)
- We need to see what's happening inside the skull, including the relative locations of blood vessels and cells and how their organization changes during injury and over time," said Warren Grayson, a researcher involved in the study, in a Hopkins press release. (medgadget.com)
- To achieve this, his team has developed a series of tissue processing, staining, and imaging steps that allow them to create impressive 3D maps of the vessels and cells within the skull. (medgadget.com)
- To begin, the team used immunofluorescent stains to label specific cell types and blood vessels with identifying tags. (medgadget.com)
- Leaky blood vessels that lose their ability to protect the spinal cord from toxins may play a role in the development of amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig's disease, according to research published in the April issue of Nature Neuroscience. (news-medical.net)
- Blood vessels run through our brain and spinal cord and supply oxygen and other nutrients, and the lining of those blood vessels constitutes a biochemical barrier to protect the central nervous system from toxins, inflammatory cells, red blood cells, blood products, and a variety of other potential toxic insults. (news-medical.net)
- Rather, the word "barrier" describes an elaborate molecular lattice that lines the insides of the blood vessels that weave throughout the spinal cord. (news-medical.net)
- It's a bit like netting with very small openings that line the inside of blood vessels. (news-medical.net)
- Today, more and more physicians and researchers are discovering the benefits of fluorescence technologies in other areas such as neurosurgery, where it offers the ability to light up blood vessels and tissue. (zeiss.de)
- Depiction of blood flow in the brain under fluorescent light (INFRARED 800 - vessels with blood flow appear brightly lit on the surgical microscope monitor) and under normal lighting (second image). (zeiss.de)
- During surgery, the patient gets injected with a special dye that passes through their bloodstream to the blood vessels at the surgical site. (zeiss.de)
- These cells clog the circulation because they are unable to flow through the small blood vessels of our bodies. (wsfa.com)
- Because the red blood cells are blocked inside the blood vessels, not enough oxygen can be delivered to the other cells and organs. (wsfa.com)
- Glioblastomas are aggressive brain cancers that are nourished by an extensive network of blood vessels. (natureasia.com)
- Because the sickle cells are stiff, they have difficulty traveling through the smallest blood vessels (capillaries), blocking blood flow and reducing oxygen supply to tissues in areas where capillaries are blocked. (msdmanuals.com)
- Bone marrow is found in the center of most bones and has many blood vessels. (cancer.gov)
- They are stiff and sticky and block small blood vessels when they get stuck together. (kidshealth.org)
- Kids who have sickle cell disease may feel pain in different parts of the body when blood vessels get clogged with sickle cells. (kidshealth.org)
- Nobody knows exactly when sickle cells might get stuck or which blood vessels might get clogged. (kidshealth.org)
- Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation. (uos.ac.uk)
- Unexpectedly, these defects were not caused by loss of α5 from Pdgfrb-Cre expressing mural cells (pericytes and vascular smooth muscle cells), which wrap around the endothelium and stabilise blood vessels, nor by defects in the heart or great vessels, but were due to abnormal development of the lymphatic vasculature. (uos.ac.uk)
- As a consequence, α5-deficient mice develop dilated, blood-filled lymphatic vessels and lymphatic capillaries that are ectopically covered with smooth muscle cells. (uos.ac.uk)
- In twin-to-twin transfusion syndrome (TTTS), the communication of placental vessels between the donor and recipient twin creates an imbalance of blood flow resulting in anemia in the donor and polycythemia in the recipient. (jcnonweb.com)
- The communication of placental vessels between the donor and recipient twin creates an imbalance of blood flow resulting in anemia in the donor and polycythemia in the recipient. (jcnonweb.com)
Transfusions17
- We describe the methods used to quantitate MPs in blood components and discuss the application of these quantitative data in routine transfusion laboratories in order to manage quality, improve the outcomes of transfusions, and minimize their complications. (medscape.com)
- Many sickle cell patients require frequent blood transfusions, and in most cases, blood from other African Americans will be the perfect match. (wsfa.com)
- It can be extremely difficult to source blood for transfusions of people with very rare blood types. (nhsbt.nhs.uk)
- Likewise, people with blood diseases, such as sickle cell anemia and thalassemia, often require repeated blood transfusions with difficult-to-source blood which has been carefully matched to minor blood group antigens in order to avoid adverse transfusion reactions. (nhsbt.nhs.uk)
- To identify a 'hit list' of proteins for removal, we collaborated with Dr Fiona Regan (NHSBT Hammersmith) who conducted a 15-month NHSBT survey to identify which antigens most commonly caused difficulty in matching blood for transfusions. (nhsbt.nhs.uk)
- Regular blood transfusions are used to treat anaemia and can help prevent other symptoms associated with sickle cell, including strokes and Acute Chest Syndrome (when blood flow to the lungs becomes blocked. (sicklecellsociety.org)
- Ethnically match blood is required as it is less likely to be rejected by people having frequent blood transfusions, and some blood types, such as the Ro subtype, are more commonly found in people of African and Caribbean heritage than people with white heritage. (sicklecellsociety.org)
- Share personal experiences of receiving life-saving blood transfusions, being a first-time blood donor, and having a family member with sickle cell. (sicklecellsociety.org)
- To evaluate the frequency and risk factors associated with such alloimmunization, we determined the transfusion history, red-cell phenotype, and development of alloantibodies in 107 black patients with sickle cell anemia who received transfusions. (unboundmedicine.com)
- We compared the results with those from similar studies in 51 black patients with sickle cell disease who had not received transfusions and in 19 nonblack patients who received transfusions for other forms of chronic anemia. (unboundmedicine.com)
- Although they received transfusions less frequently, 30 percent of the patients with sickle cell anemia became alloimmunized, in contrast to 5 percent of the comparison-group patients with other forms of anemia (P less than 0.001). (unboundmedicine.com)
- Blood transfusions are a lifesaving treatment for many Americans. (kidshealth.org)
- Blood transfusions are one of the most frequent lifesaving procedures hospitals do. (kidshealth.org)
- The earliest known blood transfusions occurred in 1665, and the first human blood transfusion was performed by Dr. Philip Syng Physick in 1795. (medscape.com)
- Sometimes kids with sickle cell disease need blood transfusions (say: trans-FEW-zyuns). (kidshealth.org)
- Patients are exposed to multiple blood transfusions throughout their life with a higher risk of contacting viruses such as major human immunodeficiency virus (HIV). (bvsalud.org)
- The aim of this study was to estimate the prevalence HIV infection in sickle cell patient accounting the number of received transfusions. (bvsalud.org)
Donors24
- They saw that all 20 of the blood donors had produced antibodies-proteins that recognize and help fight pathogens the body has encountered before-to SARS-CoV-2. (popsci.com)
- All the blood donors carried "helper" T cells, which rouse the immune system and assist antibody-producing immune cells. (popsci.com)
- About 70 percent of the donors harbored "killer" T cells, which seek out and destroy cells that have been infected by the virus. (popsci.com)
- We considered infection to be acquired outside Israel when tropic virus type 1 (HTLV-1) in blood donors from Israel is 1 infection/100,000 persons. (cdc.gov)
- H classification of geographic origin of blood donors (both uman T-cell lymphotropic virus type 1 (HTLV-1) is HTLV-1 positive and HTLV-1 negative) is given in the prevalent mostly in Japan, Africa, the Caribbean Is- online Technical Appendix (available from www.cdc.gov/ lands, and South America ( 1,2 ). (cdc.gov)
- From January 9, 1995, through December 31, 2003, a Israel is an immigration state, providing a unique op- total of 1,256,669 blood donors were screened for HTLV-1 portunity to examine the prevalence of HTLV-1 infection infection in Israel. (cdc.gov)
- Donors from Middle Eastern and East- maternal and paternal countries of birth once for each do- ern European countries were at highest risk for HTLV-1 nor, regardless of the number of blood units donated. (cdc.gov)
- and Ma- systematic screening of blood donors, enabled us to exam- gen David Adom National Blood Services, Ramat Gan, Israel (V. ine the global epidemiology of HTLV-1 infection. (cdc.gov)
- Blood is first collected from donors and processed into different components, after which they are stored until needed in hospitals around the world. (plos.org)
- Finding donors whose blood types match the is crucial to reducing their complications. (wsfa.com)
- The LifeSouth Community Foundation is also providing a monetary grant to the Sickle Cell Foundation of Greater Montgomery in honor of its blood donors as part of Thursday's event. (wsfa.com)
- increase levels of confidence in giving blood and recruit new donors to the blood donation register. (sicklecellsociety.org)
- NHSBT estimate that 40,000 new Black-heritage donors are required this year to meet the needs of sickle cell patients across England. (sicklecellsociety.org)
- It is still vitally important that people continue to sign up to be donors and start donating blood. (sicklecellsociety.org)
- Donors need to wait 7 full days from having a Covid-19 vaccine before donating blood on the 8th day. (sicklecellsociety.org)
- We assessed the effect that racial differences might have on the frequency of alloimmunization by comparing the red-cell phenotypes of patients and blood-bank donors (n = 200, 90 percent white). (unboundmedicine.com)
- Comparison of red-cell phenotypes in the three study groups (the patients with sickle cell anemia, the patients with other forms of anemia, and the blood donors) revealed statistically significant differences between the patients with sickle cell anemia and the donors but not between the patients with other forms of anemia and the donors. (unboundmedicine.com)
- This will directly benefit patients coming into hospital, but also alleviate the constant pressures on blood supplies and the need for blood donors. (ivyroses.com)
- So there's always a need for blood donors. (kidshealth.org)
- About 15% of blood donors are high school and college students. (kidshealth.org)
- Mice and immune cells from blood donors were used for the investigations. (idw-online.de)
- Primary immune cells from blood donors were investigated in cooperation with Hendricus Garritsen from the Klinikum Braunschweig. (idw-online.de)
- Through international relationships with other registries, physicians and patients worldwide have access to 24.5 million potential donors and 622,000 cord blood units. (cryo-cell.com)
- Blood donors were included consecutively after a medical interview and screened for Human Immunodeficiency Virus, Hepatitis B virus, Hepatitis C virus and Treponema pallidum infections. (bvsalud.org)
Bone23
- University of Oxford researchers found that high blood glucose, a hallmark of diabetes, alters stem cells in the bone marrow that go on to become white blood cells called macrophages. (ox.ac.uk)
- Researchers also extracted stem cells from the bone marrow of mice with and without diabetes and transplanted these into mice with normal blood glucose levels. (ox.ac.uk)
- When the team looked at the mouse macrophages in more detail they found that those that had developed from stem cells in the bone marrow of diabetic mice had been permanently altered to become more inflammatory. (ox.ac.uk)
- A low white blood count is often caused by an autoimmune disorder, cancer or issues in the bone marrow. (reference.com)
- Bone marrow stem cells are extremely sensitive to the primary by-product of alcohol, which causes permanent damage to their DNA claims researchers from the Medical Research Council (MRC) Lab of Molecular Biology. (cellmedicine.com)
- When I first worked in this field nearly 30 years ago there was little interest in stem cells beyond the highly specialized experts working on bone marrow transplantation. (cbc-network.org)
- Production of red blood cells begins with stem cells in the bone marrow and ends with the release of mature red blood cells into the body's circulation. (merckvetmanual.com)
- Within the bone marrow, all blood cells begin from a single cell type called a stem cell. (merckvetmanual.com)
- Erythropoietin, a hormone produced by the kidneys, stimulates development of red blood cells in the bone marrow. (merckvetmanual.com)
- Many disorders can cause the bone marrow to produce too many or too few white blood cells, or to produce white blood cells that do not function as they should. (dana-farber.org)
- White blood cells are manufactured in bone marrow - the spongy tissue inside some of your larger bones. (xshotpix.com)
- Five different and diverse types of leukocytes exist, but they are all produced and derived from a multipotent cell in the bone marrow known as a hematopoietic stem cell. (techxplore.com)
- They irradiated the mice to remove their blood cells and then gave them mutated blood cells that contained the Tet2 mutation via a bone marrow transplant. (medscape.com)
- The present researchers are using stem cells from a number of sources of human adult tissue including whole blood, bone marrow, adipose (fatty) tissue , dental pulp and umbilical cord. (ivyroses.com)
- They have succeeded in growing cartilage , skin , adipose and visceral tissues and have recently managed to grow bone from blood-derived stem cells. (ivyroses.com)
- Adult acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes a large number of abnormal blood cells. (cancer.gov)
- Tests that examine the blood and bone marrow are used to diagnose AML. (cancer.gov)
- Normally, the bone marrow makes blood stem cells (immature cells ) that become mature blood cells over time. (cancer.gov)
- Bangalore-based DKMS BMST Foundation India, part of Deutsche KnochenMarkSpenderdatei" or "German Bone Marrow Donor File") international nonprofit bone marrow donor center based in Germany, is dedicated to the fight against blood cancer and other blood disorders, such as thalassemia and aplastic anemia. (curriculum-magazine.com)
- G-CSF occurs naturally in the body and increases the number of stem cells that are produced in the bone marrow and flushed into the bloodstream. (curriculum-magazine.com)
- In some cases, a bone marrow transplant can cure sickle cell disease. (kidshealth.org)
- Bone marrow transplants replace the sickle cells with healthy cells from someone else. (kidshealth.org)
- Reauthorization of this significant, life-saving bill will advance the important work of the bone marrow and cord blood programs to promote new discoveries within the fields of cellular therapy and regenerative medicine," said Sen. Orin Hatch (R-Utah), lead sponsor of the bill in the Senate. (cryo-cell.com)
20221
- Blood;2022 Aug 01. (bvsalud.org)
Hemoglobin14
- Red blood cells, or erythrocytes, contain the hemoglobin that carries oxygen and carbon dioxide around the body. (giantmicrobes.com)
- Hemoglobin gives red blood cells their Characteristic color. (giantmicrobes.com)
- Sickle cell anemia, also known as Sickle Cell Disease (SCD), is a condition in which the hemoglobin is abnormal, causing the red blood cells to be rigid. (wsfa.com)
- Oxygen molecules attach themselves to carrier molecules, called hemoglobin, which are the iron-containing proteins in red blood cells that give the cells their red color. (merckvetmanual.com)
- Oxygen is carried from the lungs and delivered to all body tissues by the hemoglobin within red blood cells. (merckvetmanual.com)
- An animal's metabolism is geared to protect both the red blood cells and the hemoglobin from damage. (merckvetmanual.com)
- Interference with the formation or release of hemoglobin, the production or survival of red blood cells, or their metabolism causes disease. (merckvetmanual.com)
- Red blood cells contain a protein called hemoglobin, which carries oxygen from the lungs to the rest of the body. (xshotpix.com)
- Sidney M. Wolfe, MD. Cell-Free Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death. (citizen.org)
- Sickle cell disease is an inherited genetic abnormality of hemoglobin (the oxygen-carrying protein found in red blood cells) characterized by sickle (crescent)-shaped red blood cells and chronic anemia caused by excessive destruction of the abnormal red blood cells. (msdmanuals.com)
- Red blood cells contain hemoglobin, a protein that enables them to carry oxygen from the lungs and deliver it to all parts. (msdmanuals.com)
- In sickle cell disease, the red blood cells contain an abnormal form of hemoglobin (the protein that carries oxygen). (msdmanuals.com)
- The abnormal form of hemoglobin is called hemoglobin S. When red blood cells contain a large amount of hemoglobin S, they can become deformed into a sickle shape and less flexible. (msdmanuals.com)
- Anemia describes a diminished circulating red cell mass, expressed as grams of hemoglobin per 100 cc of whole blood. (medscape.com)
Genetic14
- Sickle-cell disease is a genetic blood disorder that affects the haemoglobin within the redblood cells. (who.int)
- The study, focusing on a small number of patients and using sophisticated blood analysis technology, demonstrated that circulating tumor cells detected in blood have the potential to reveal important genetic information that could guide treatments selection in the future, and suggest targets for new therapies. (medindia.net)
- Focusing both on genes that have previously been implicated in tumor progression, plus other genes important to cancer biology, the researchers found changes in multiple genetic pathways that appear to be in common among the men's circulating tumor cells. (medindia.net)
- These endothelial cells are characterized by the same genetic alterations as the glioblastoma cells and seem to be derived from glioblastoma stem-like cells. (natureasia.com)
- Sometimes a low white blood cell count is something you are born with (a genetic condition), which may or may not be a cause for concern. (xshotpix.com)
- An experimental gene therapy that modifies the genetic code of key blood cells to help them fight cancer showed promise in a preliminary study, with more than one-third of lymphoma patients showing no signs of the disease six months after one treatment. (advisory.com)
- Genetic mutations in peripheral blood cells might be a contributing cause of coronary heart disease (CHD) and atherosclerosis, especially in older people, new research suggests. (medscape.com)
- The presence of fetal cells in maternal circulation as early as 6 weeks of gestation has opened new avenues of noninvasive approach to prenatal diagnosis in identifying successfully both Chromosome and molecular genetic abnormalities. (who.int)
- A number of clinical and laboratory studies are continuing throughout the world to determine the feasibility of isolation of fetal cells from maternal blood and its subsequent use in genetic diagnosis by FISH and PCR technology. (who.int)
- CD7 is an attractive antigen for targeting T-ALL , but overlapping expression on healthy T cells leads to fratricide of CD7- CAR T cells , requiring additional genetic modification. (bvsalud.org)
- DNA is the genetic material of the cell. (khanacademy.org)
- Some bacteria also have specialized structures found on the cell surface, which may help them move, stick to surfaces, or even exchange genetic material with other bacteria. (khanacademy.org)
- Cells make those molecules according to the genetic blueprints. (engineeringchallenges.org)
- Sickle cell disease, a common genetic disorder in African Americans, can lead to a stroke. (cdc.gov)
Antibodies15
- Age was described as mean ± standard de- began screening all blood units for HTLV-1 antibodies in viation. (cdc.gov)
- The researchers found that blood cancer patients with COVID-19 who had higher CD8 T cells, many of whom had depleted antibodies from cancer treatments, were more than three times likelier to survive than patients with lower levels of CD8 T cells. (newswise.com)
- Additionally, because the current COVID-19 mRNA vaccinations induce both antibody and T cell responses, the findings suggest that vaccination of blood cancer patients could provide protection through T cell immunity, despite the absence of antibodies. (newswise.com)
- Immune profiling of 214 patient blood samples at Memorial Sloan Kettering and Penn Medicine revealed that patients with blood cancers, in particular patients treated with anti-CD20 antibodies, had decreased B cells and antibodies compared to patients with solid cancers and patients without cancer. (newswise.com)
- Additional analyses also revealed that among patients with blood cancers, including patients treated with chemotherapy and anti-CD20 antibodies, those with higher CD8 T cell counts had a 3.6 fold greater likelihood of survival compared to those with lower counts. (newswise.com)
- Thus, the authors concluded, CD8 T cells may influence recovery from COVID-19 when B cells and antibodies are deficient. (newswise.com)
- The next step is to better understand the immune responses blood cancer patients with COVID-19 experience after they recover and how protective their immunity is without B cells and antibodies, the researchers said. (newswise.com)
- Transfusion therapy for sickle cell anemia is limited by the development of antibodies to foreign red cells. (unboundmedicine.com)
- Of the 32 alloimmunized patients with sickle cell anemia, 17 had multiple antibodies and 14 had delayed transfusion reactions. (unboundmedicine.com)
- Open tubular capillaries coated with anti-CD4, anti-CD14, or anti-CD19 antibodies were used as affinity chromatography columns to separate target blood cells. (ttu.edu)
- The immune system makes proteins called antibodies that act as protectors if foreign cells enter the body. (kidshealth.org)
- Depending on which blood type you have, your immune system will make antibodies to react against other blood types. (kidshealth.org)
- If a patient gets the wrong blood type, the antibodies immediately set out to destroy the invading cells. (kidshealth.org)
- Because your blood contains the A marker, it makes B antibodies. (kidshealth.org)
- Your body will have both A and B antibodies and will therefore feel the need to defend itself against A, B, and AB blood. (kidshealth.org)
Oxygen12
- Haemoglobin (the main component of red blood cells) is an iron -containing protein that facilitates transportation of oxygen from the lungs to tissues and carbon dioxide from tissues to the lungs. (wn.com)
- Red blood cells primarily carry oxygen and collect carbon dioxide through the use of haemoglobin , and have a lifetime of about 120 days. (wn.com)
- The main function of red blood cells (also called erythrocytes) is to carry oxygen to the tissues, where it is required for cellular metabolism. (merckvetmanual.com)
- Oxygen is used by cells to produce energy that the body needs. (merckvetmanual.com)
- Having too few red blood cells means the blood carries less oxygen, resulting in fatigue and weakness. (merckvetmanual.com)
- When the number of red blood cells is too high, which is called polycythemia, blood can become too thick, impairing the ability of the heart to deliver oxygen throughout the body. (merckvetmanual.com)
- The total number of red cells, and thus the oxygen-carrying capacity, remains constant over time in healthy animals. (merckvetmanual.com)
- Sickle-cell anemia is a hereditary blood disorder that inhibits the blood's ability to carry oxygen. (jax.org)
- The sickle-shaped cells become more numerous when people have infections or low levels of oxygen in the blood. (msdmanuals.com)
- Red blood cells that carry oxygen and other substances to all tissues of the body. (cancer.gov)
- [3] studied 98 twins and found a significant intertwin difference in the Log 10 (NRBC/100 white blood cell [WBC]), concluding that the smaller twins experienced a relative lack of oxygen compared with the larger twin in utero . (jcnonweb.com)
- Blood carries oxygen to cells in the body. (cdc.gov)
Platelet6
- A number of studies have demonstrated the presence of MPs in packed red blood cells, platelet concentrate, and fresh frozen plasma in storage. (medscape.com)
- Blood Cells themed gift box includes these mini microbes: Red Blood Cell, White Blood Cell, Plasma, Platelet, and Antibody. (giantmicrobes.com)
- The stem cell divides to form immature forms of red blood cells, white blood cells, or a platelet-producing cell. (merckvetmanual.com)
- A blood stem cell goes through several steps to become a red blood cell, platelet, or white blood cell. (cancer.gov)
- Fresh whole blood has long been thought of as the criterion standard for transfusion, but the advent of whole blood fractionation techniques subsequent to World War II provided a means of more efficient use of the various components (i.e., packed red blood cells [PRBCs], fresh frozen plasma [FFP], individual factor concentrates, platelet concentrates, cryoprecipitate). (medscape.com)
- Blood stem cell donation is similar to blood platelet donation. (curriculum-magazine.com)
Neutrophils1
- Neutrophils and monocytes are white blood cells that are triggered by the body's immune system to arrive at a site of infection through a process known as chemotaxis, In eczema, there is a reduction in the cell-mediated immune response. (xshotpix.com)
People with sickle cell5
- There is no evidence to suggest that donating blood causes any additional risk of harm or injury to people with sickle cell trait. (cdc.gov)
- them from donating to Some blood donation centers may have rules about the specific those whose lives may parts of blood that they will take from people with sickle cell trait. (cdc.gov)
- People with sickle cell trait are able, and encouraged to register to be an organ and tissue donor. (cdc.gov)
- People with sickle cell trait can donate blood. (sicklecellsociety.org)
- In people with sickle cell trait, red blood cells are not fragile and do not break easily. (msdmanuals.com)
Tumor22
- Researchers used lasers to detect and destroy tumor cells in the veins of patients with melanoma. (ieee.org)
- Tumor cells that spread cancer via the bloodstream face a new foe: a laser beam, shined from outside the skin, that finds and kills these metastatic little demons on the spot. (ieee.org)
- Killing these circulating tumor cells, or CTCs, in the bloodstream before they have a chance to settle could help prevent metastasis and save lives. (ieee.org)
- Heat from the laser causes vapor bubbles to form on the tumor cells. (ieee.org)
- In one patient, we destroyed 96 percent of the tumor cells" that crossed the laser beam, says Zharov. (ieee.org)
- The researchers found that after stimulation in vitro, monocytes from food-allergic children made higher levels of cytokines known to be involved in allergy, such as tumor necrosis factor α (TNF-α), compared to the same cells from nonallergic children. (the-scientist.com)
- Certain subsets of these circulating tumor cells can cause metastasis. (nanowerk.com)
- In cases of breast cancer, it is known that these cells can differ from the original tumor cells, which allows them to survive treatment to cause later recurrence. (nanowerk.com)
- The eDAR process has a recovery of over 93% (number of runs n=9) with a zero false positive rate (n=8) and provides direct easy access to individual isolated live cells for downstream single-cell manipulation and analysis (CTCs=circulating tumor cells). (nanowerk.com)
- The detection of circulating tumor cells is a difficult challenge because it requires the detection of quantities as low as one to ten cells per milliliter of blood-in the presence of large numbers of red blood cells and other cells. (nanowerk.com)
- The blood is initially marked with fluorescent markers that specifically bind to the desired tumor cells. (nanowerk.com)
- tumor cells are larger and are trapped. (nanowerk.com)
- By using a second marker, certain subpopulations, such as tumor stem cells, can be identified. (nanowerk.com)
- Blood markers associated with prostate tumor resistance to two common hormone therapies have been discovered by Duke Cancer Institute researchers. (medindia.net)
- Multiple key gene alterations in the circulating prostate tumor cells of patients who had developed resistance to abiraterone or enzalutamide discovered. (medindia.net)
- Armstrong and colleagues from the DCI and the Duke Molecular Physiology Institute used a process called array-based comparative genomic hybridization to analyze the genome of the circulating tumor cells of 16 men with advanced, treatment-resistant prostate cancer. (medindia.net)
- Our research provides evidence supporting the ability to measure gains and losses of large scale sections of the circulating tumor cells genome in men with prostate cancer," said co-author Simon Gregory, Ph.D., director of the Section of Genomics and Epigenetics in the Duke Molecular Physiology Institute. (medindia.net)
- 4 Monolayer cultures of human tumor cell lines have been the general model in these efforts. (nature.com)
- Primary cultures of patient tumor cells represent an alternative tumor model system that has received very little attention in the context of cancer drug screening and development. (nature.com)
- Research efforts using primary cultures of patient tumor cell models have mainly focused on prediction of clinical activity of cancer drugs for individual patients. (nature.com)
- In addition, perform a peripheral blood examination for circulating tumor cells by flow cytometry. (medscape.com)
- Sometimes leukemia cells form a solid tumor called a myeloid sarcoma . (cancer.gov)
Serum2
- Isolated using density gradient separation or red blood cell lysis and cryopreserved in animal component-free CryoStor®CS10 medium (Catalog #07930) or serum-free medium, cells are collected using Institutional Review Board (IRB)-approved consent forms and protocols. (stemcell.com)
- In addition, perform serum β2 microglobulin (B-cell lymphoma) testing. (medscape.com)
Donor15
- In the field of transfusion medicine, a number of studies have documented increased levels of MPs in blood products, which have been associated with multiple factors, including donor variability, blood component processing, and storage. (medscape.com)
- This is largely due to an inability to filter different parts of the blood at certain blood donation/collection centers, and not due to Education is needed to concerns for the safety of the potential donor with sickle cell trait. (cdc.gov)
- For those looking to donate blood at this event, please call the Sickle Cell Foundation of Greater Montgomery, Inc. at 334-286-9122 or 1-888-767-4255, or call Stephanie Tyus-Shorter, Sickle Cell Outreach Coordinator, at 334-260-0803 to sign up to be a donor or for more information. (wsfa.com)
- Explain what happens when you register to be a blood donor. (sicklecellsociety.org)
- We conclude that alloimmunization is a common, clinically serious problem in sickle cell anemia and that it is partly due to racial differences between the blood-donor and recipient populations. (unboundmedicine.com)
- To get a blood transfusion safely, a person's immune system must recognize the donor cells as a match to his or her own cells. (kidshealth.org)
- Her stem cell transplant will only be possible if she finds a matching blood stem cell donor. (curriculum-magazine.com)
- A blood stem cell transplant infuses healthy blood stem cells from a matching donor to the patient. (curriculum-magazine.com)
- A successful blood stem cell transplant in 70% to 90% of these patients may give them a second chance at life, depending on the disease condition and the donor type. (curriculum-magazine.com)
- The remaining blood is routed back to the donor through the other arm. (curriculum-magazine.com)
- Through arteriovenous anastomosis, the blood flows from the donor to the recipient. (jcnonweb.com)
- If laser ablation is delayed, the continuous process of blood flowing unidirectionally makes the donor anemic. (jcnonweb.com)
- Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
- Standard leukopheresis processing of blood from the donor was performed without problems. (cdc.gov)
- The Cord Blood Association, together with the National Marrow Donor Program (NMDP), worked tirelessly with members of Congress this year and testified in support of the legislation that totals $115 million for five years for the National Cord Blood Inventory (NCBI) and $150 million in that same period for blood and marrow transplant programs through the C.W. Bill Young Transplantation Program. (cryo-cell.com)
Mice7
- Scientists in Sweden discovered a group of nerve cells in the brains of mice that affect blood pressure as well as other cardiovascular activity-and can cause problems if they're missing, LiveScience reports. (newser.com)
- Basically, the cells reside in part of the brain that helps regulate involuntary functions including blood pressure, and mice with thyroid hormone problems are missing the cells, which leads to high blood pressure and other problems. (newser.com)
- The team studied mice with a mutation in a gene for superoxide dismutase 1 (SOD-1), which in healthy people and mice plays an important role keeping cells safe from damaging molecules known as free radicals. (news-medical.net)
- In the Nature Neuroscience paper, the group from Rochester's Center for Neurodegenerative and Vascular Brain Disorders and UCSD showed that a breakdown in the natural barrier between the blood and the spinal cord breaks down early on in mice destined to get ALS, long before nerve cells appear sick or die. (news-medical.net)
- In the study, the presence of clonal hematopoiesis of indeterminate potential (CHIP) - defined as an expanded somatic blood-cell clone in persons without other hematologic abnormalities - was associated with nearly a doubling in the risk for CHD in humans and with accelerated atherosclerosis in mice. (medscape.com)
- Adoptive transfer with expanded autologous Treg prevented islet xenograft rejection in human PBMC-reconstituted mice by inhibiting graft infiltration of effector cells and their function. (diabetesjournals.org)
- Epidermal growth factor increases insulin secretion and lowers blood glucose in diabetic mice. (bvsalud.org)
Immune cells7
- In MS, immune cells called T-cells treat myelin - which insulates nerves - as a foreign invader and destroy it. (newscientist.com)
- Researchers observed that people who recover from COVID-19 carry immune cells in their blood called T cells that target the novel coronavirus. (popsci.com)
- Ramirez and her colleagues also investigated how immune cells from stored blood samples that had been collected between 2015 and 2018-well before the novel coronavirus appeared on the scene-reacted to the viral proteins. (popsci.com)
- FLICKR, DEAN HOCHMAN Children prone to developing food allergies are born with some immune cells ready to cause inflammation, according to a study published today (January 13) in Science Translational Medicine . (the-scientist.com)
- Peter Vuillermin , a pediatric specialist at Deakin University in Victoria, Australia, and his colleagues examined the composition of immune cells in the cord blood of newborns enrolled in the Barwon Infant Study (BIS), a large-scale project aimed at identifying prenatal and early-life causes of noncommunicable diseases. (the-scientist.com)
- The team found that cord blood from infants who went on to develop confirmed food allergies had lower frequencies of Tregs and larger ratios of CD14+ monocytes to CD4+ T cells-two populations of immune cells that are inversely related in cord blood. (the-scientist.com)
- In 2013, the scientists discovered that immune cells in the blood and brain of mammals produce itaconic acid - a substance that had previously only been found in the metabolism of fungi. (idw-online.de)
Peripheral Blood Stem Cell1
- Blood stem cells are donated through the Peripheral Blood Stem Cell donation (PBSC) method. (curriculum-magazine.com)
Leukocytes7
- White blood cells, or Leukocytes, are your body's white knights. (giantmicrobes.com)
- Enhanced apoptosis in the leukocytes of peripheral blood of PEM patients may be a marker of increased infection and immune disturbances. (who.int)
- White blood cells ( WBCs ), or leukocytes (also spelled "leucocytes"), are cells of the immune system defending the body against both infectious disease and foreign materials. (techxplore.com)
- Leukocytes are found throughout the body, including the blood and lymphatic system. (techxplore.com)
- The number of leukocytes in the blood is often an indicator of disease. (techxplore.com)
- The physical properties of leukocytes, such as volume, conductivity, and granularity, may change due to activation, the presence of immature cells, or the presence of malignant leukocytes in leukemia. (techxplore.com)
- In the original blood sample, only 14.2% of the leukocytes were CD4+ cells. (ttu.edu)
Anemia9
- Anemia, polycythemia, and white blood cells disorders. (mayoclinic.org)
- When the number of red blood cells is too low, this is called anemia. (merckvetmanual.com)
- Anemia is a condition in which a person has an abnormally low red blood cell count, which can cause the skin to appear pale. (xshotpix.com)
- About one-third of patients developed anemia or blood-count-related problems during the study. (advisory.com)
- Worsening anemia, fever, and shortness of breath with pain in the long bones, abdomen, and chest can indicate sickle cell crisis. (msdmanuals.com)
- Overview of Anemia Anemia is a condition in which the number of red blood cells is low. (msdmanuals.com)
- Blood cancer and blood disorders like Thalassemia and Aplastic Anemia are on the rise and every 5 minutes, someone in India is diagnosed with the disease. (curriculum-magazine.com)
- Lymphoma, Leukemia, Myeloma and Hodgkin disease & other blood disorders such as Aplastic Anemia & Thalassemia can be treated with a blood stem cell transplant. (curriculum-magazine.com)
- That leads to too few red blood cells, a condition called anemia . (kidshealth.org)
Proteins10
- For the experiment, Ramirez and her colleagues collected blood samples donated by 20 adults who'd recovered from relatively mild cases of COVID-19 and exposed them to proteins from SARS-CoV-2. (popsci.com)
- She and her team also detected two types of T cells that sprung into action when viral proteins were near. (popsci.com)
- While the T cells reacted most strongly to the spike protein, they also recognized several other proteins from SARS-CoV-2. (popsci.com)
- Initially, genes associated with membrane proteins were targeted, such as glycophorin A, as these were easiest to detect presence/absence from the cell surface. (nhsbt.nhs.uk)
- most blood groups are determined by membrane proteins (or sugars attached to these proteins), therefore the removal of membrane proteins potentially enables us to make RBCs with increased transfusion compatibility (Image right: Multiple blood group proteins are targeted for removal) . (nhsbt.nhs.uk)
- The blood group proteins Rh, Kell, Duffy and GPB, as well as the ABO group (a carbohydrate), were identified as key targets. (nhsbt.nhs.uk)
- These markers (also called antigens ) are proteins and sugars that our bodies use to identify the blood cells as belonging in us. (kidshealth.org)
- Most bacteria are, however, surrounded by a rigid cell wall made out of peptidoglycan , a polymer composed of linked carbohydrates and small proteins. (khanacademy.org)
- For instance, although archaea also have a cell wall, it's not made out of peptidoglycan-although it does contain carbohydrates and proteins. (khanacademy.org)
- Proteins are usually found in the blood and only in small amounts in the urine. (testing.com)
Symptoms of Sickle Cell Di1
- What Are the Signs & Symptoms of Sickle Cell Disease? (kidshealth.org)
Immature cells1
- This usually entails increased numbers of cells and an increase in the percentage of immature cells (mainly band zcells) in the blood. (medlineplus.gov)
Cancers8
- Among the genomic changes in the patients' individual cancers, we were able to find key similarities between the cancer cells of men who have hormone-resistant prostate cancer," Armstrong said. (medindia.net)
- Learn more about the heart of our mission-delivering cures for blood cancers-in our 2020 Report to the Community. (bethematch.org)
- After your baby is born, that lifeline can give hope to patients with blood cancers. (bethematch.org)
- Mission advocates for patients with blood cancers. (bethematch.org)
- We can inform patients that while their vaccine response likely will not be as robust as their friends/family who don't have blood cancers, it is still critical and potentially lifesaving. (newswise.com)
- We aim to improve the understanding of the role of cancer stem cells in a range of cancers, through world-leading research. (cardiff.ac.uk)
- In which condition is stem cells transplant used to treat blood cancers? (curriculum-magazine.com)
- Enacting this bill will also reaffirm the commitment that Congress made three decades ago to help patients with blood cancers and other life-threatening diseases by increasing access to life-saving transplants. (cryo-cell.com)
Endothelial cells2
- Two groups now show that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. (natureasia.com)
- Analysis of the expression of Pdgfrb during lymphatic development suggests that these defects probably arise from loss of α5β1 integrin in subsets of specialised Prox1(+)Pdgfrb(+) venous endothelial cells that are essential for the separation of the jugular lymph sac from the cardinal vein and formation of the lymphovenous valve leaflets. (uos.ac.uk)
Inflammatory4
- Those from people with type 2 diabetes showed a greatly exaggerated inflammatory response compared to the cells from people without the condition. (ox.ac.uk)
- A team of researchers from Australia and China has shown that a consequence of this increased monocyte activity could be a deficit of anti-inflammatory T regulatory cells (Tregs). (the-scientist.com)
- Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce nonclassic 'Th2-type' immunity associated with development of food allergy," Science Translational Medicine, doi:10.1126/scitranslmed.aad4322, 2016. (the-scientist.com)
- This molecule could be a drug candidate that can be further developed to treat shock resulting from blood poisoning and autoimmune diseases such as psoriasis and inflammatory bowel disease (IBD) - without the known side effects of anti-inflammatory drugs currently in use. (idw-online.de)
Infection7
- Doctors often order a complete blood count, or CBC, because they are searching for abnormalities in the blood stream, such as too many white blood cells, which may be a sign of infection or inflammation. (reference.com)
- In addition, serologic testing for HIV infection should be considered in patients with coexistent HIV risk factors, aggressive histologies (DLBCL, Burkitt or T-cell lymphoma), or unusual clinical presentations. (medscape.com)
- Granulocytes , which are white blood cells that help fight infection and disease. (cancer.gov)
- Kids with sickle cell disease may need to go to the hospital if they have a lot of pain or a serious infection. (kidshealth.org)
- The part of the blood that protects from vaccinia infection is taken out, cleaned, and bottled. (cdc.gov)
- Since the white blood cells affect how well the body fights off infection, abnormal white blood cells can lead to severe, life-threatening conditions within the body. (yourlawyer.com)
- BRICS is a joint research centre of TU Braunschweig, the Helmholtz Centre for Infection Research (HZI) and the Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH. (idw-online.de)
Body's3
- Plasma also helps maintain normal blood pressure and helps regulate the body's temperature. (giantmicrobes.com)
- LifeSouth Community Blood Center in Montgomery is hosting a special event to help us better understand how the disorder affects the body's red blood cells. (wsfa.com)
- The rate of blood cell production is determined by the body's needs. (merckvetmanual.com)
Leukocyte1
- A dipstick test may check for the presence of an enzyme called leukocyte esterase that is found in white blood cells. (testing.com)
RBCs4
- Red blood cells (RBCs) are known to undergo compositional changes during storage, which may impact the cells' function and eventually the recipients' health. (plos.org)
- The RBCs' unique ability to deform is intrinsically related to the complex interplay between the spectrin network and the cytoplasmic membrane, which form the outer layer of the cell. (plos.org)
- for example replicating disease states for study, improving properties of lab grown blood, or even utilising RBCs as drug delivery vehicles. (nhsbt.nhs.uk)
- Using CRISPR-Cas9 we were able to generate BEL-A lines deficient for each of these targets and confirmed that the cells were still capable of developing into reticulocytes (young RBCs). (nhsbt.nhs.uk)
Clots2
- Problems with severe bleeding and blood clots may occur. (cancer.gov)
- Aspirin may help reduce your risk for stroke by preventing blood clots, but you should check with your doctor before taking aspirin to make sure it is right for you. (cdc.gov)
Clinical11
- Considering the clinical importance of MP levels, transfusion laboratories should routinely screen blood products for them. (medscape.com)
- [ 6-9 ] This relationship is supported by clinical studies that have shown an association between adverse clinical outcomes and blood products that have been stored for longer periods of time. (medscape.com)
- The purpose of the public workshop is to discuss new methodologies for pre-clinical evaluation of the safety and efficacy of red blood cell transfusion products. (aabb.org)
- We have developed a method that allows us to examine the whole genome of rare circulating cancer cells in the blood, which is unique in each patient, and which can change over time during treatment," said senior author Andrew Armstrong, M.D., a medical oncologist and co-director of Genitourinary Clinical-Translational Research at the Duke Cancer Institute (DCI). (medindia.net)
- All sorts of claims are made for the current and future clinical applications of these cells based sometimes on fact and sometimes on wishful thinking. (cbc-network.org)
- It is further expected that if and when ' blood production ' is fully scaled up to serve the NHS, such production systems will be able to operate continuously, enabling constant production of red blood cells for clinical use. (ivyroses.com)
- Lastly, to gain insight into the behavior of CD19- CAR T cells with low levels of CD7 gene expression (CD7lo) in humans , we mined single- cell gene and T-cell receptor (TCR) expression data sets from our institutional CD19- CAR T-cell clinical study . (bvsalud.org)
- Human γδ T cells, which play innate and adaptive, protective as well as destructive, roles in the immune response, were discovered in 1986, but the clinical significance of alterations of the levels of these cells in the peripheral blood in human diseases has not been comprehensively reviewed. (tau.ac.il)
- These collective data suggest that enumeration of γδ T cells and their subsets in the peripheral blood of patients could be a useful tool to evaluate diagnosis and prognosis in the clinical setting. (tau.ac.il)
- Bank, I & Marcu-Malina, V 2014, ' Quantitative Peripheral Blood Perturbations of γδ T Cells in Human Disease and Their Clinical Implications ', Clinical Reviews in Allergy and Immunology , vol. 47, no. 3, pp. 311-333. (tau.ac.il)
- T cell-mediated rejection remains a barrier to the clinical application of islet xenotransplantation. (diabetesjournals.org)
Disorder5
- A white blood count that is too high may indicate an immune system disorder or a reaction to medication. (reference.com)
- Sickle cell disease is an inherited blood disorder that primarily affects people of African ancestry. (wsfa.com)
- Donated blood forms a key part of the current treatments for sickle cell disorder. (sicklecellsociety.org)
- Heart Failure (HF) Heart failure is a disorder in which the heart is unable to keep up with the demands of the body, leading to reduced blood flow, back-up (congestion) of blood in the veins and lungs, and/or. (msdmanuals.com)
- Having a personal history of a blood disorder such as myelodysplastic syndrome . (cancer.gov)
Bacteria2
- After all, red blood cells dominate the 70 trillion cells and friendly bacteria in your body. (giantmicrobes.com)
- Archaea may also have most of these cell surface features, but their versions of a particular feature are typically different from those of bacteria. (khanacademy.org)
Researchers7
- In a study published today in Science Translational Medicine , researchers revealed that their system accurately detected these cells in 27 out of 28 people with cancer, with a sensitivity that is about 1,000 times better than current technology. (ieee.org)
- Of course, the extra weight and the bacon are still factors, but if the same cell cluster exists in humans, researchers think it could lead to a new way of treating high blood pressure and other heart problems. (newser.com)
- In the journal Angewandte Chemie ( 'Sensitive and High-Throughput Isolation of Rare Cells from Peripheral Blood with Ensemble-Decision Aliquot Ranking' ), researchers at the University of Washington (Seattle, USA) describe a new chip-based method that allows for the detection and isolation of tiny concentrations of such cells in blood. (nanowerk.com)
- The results are quite impressive, with the researchers using the map to identify niches within the skull that contain communities of stem cells. (medgadget.com)
- For the study, researchers administered a so-called CAR-T cell therapy. (advisory.com)
- Researchers are developing highly targeted methods of isolating and purifying haematopoietic stem cells (HSCs) which are the progenitors of red blood cells , as well as environments that support the transition of HSCs into red blood cells in the laboratory. (ivyroses.com)
- Researchers at the University of Washington have developed an injectable material that can help blood clot faster and more effectively, plugging up the wound to stop the bleeding. (engineeringchallenges.org)
Hematopoietic stem1
- Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
Cord blood17
- Scientists who studied nearly 700 newborns for one year observed that monocytes found in umbilical cord blood of infants who had food allergies a year later were more active and proinflammatory than those in newborns without such allergies. (the-scientist.com)
- Whatever the cause, Berin said a cord blood-based test could be a useful predictor of which children are most at risk of developing food allergy and which would benefit most from early intervention. (the-scientist.com)
- But so can a cure-a marrow or cord blood transplant. (bethematch.org)
- Learn more about donating cord blood and how cord blood saves lives. (bethematch.org)
- News and info by and for marrow or cord blood transplant patients, their families and friends. (bethematch.org)
- Today we hear about stem cells coming from cord blood, placenta, embryos, the fat collected during liposuction and even from baby teeth! (cbc-network.org)
- Hetastarch (HES) processing of umbilical cord blood has been the industry standard since 1988, and thousands of transplants using HES-processed cord blood have been successful. (cryo-cell.com)
- In 2009, a new advanced technology for processing cord blood known as PrepaCyte-CB was developed. (cryo-cell.com)
- Cryo-Cell is the first major cord blood bank to embrace this superior technology, which yields the maximum recovery of healthy stem cells and provides superior red blood cell depletion over all other methods. (cryo-cell.com)
- Our premium processing method is just another example of how Cryo-cell continues to set the gold standard in the cord blood industry . (cryo-cell.com)
- As the premier cord blood processing technology, PrepaCyte-CB has been shown to lead to earlier engraftment. (cryo-cell.com)
- PrepaCyte-CB recovers significantly more viable stem cells than the processing methods used by other cord blood banks . (cryo-cell.com)
- In a comparison conducted by the St. Louis Cord Blood Bank, PrepaCyte-CB recovered the highest percentage of colony-forming stem cell units (CFUs), capturing 51 percent more than the standard HES 1 method as offered by Viacord and 70 percent more than the AutoXpress (AXP) 2 method as used by Cord Blood Registry (CBR). (cryo-cell.com)
- Through our commitment to quality , we are able to offer the best cord blood product when it comes to what matters most. (cryo-cell.com)
- The bill, now on its way to the President's desk, authorizes $23 million per year for the next five years for cord blood inventory growth and diversity. (cryo-cell.com)
- Rep. Chris Smith (R-NJ), lead sponsor of the House version of the bill, said, "It remains one of the best kept secrets in America that umbilical cord blood stem cells and adult stem cells in general are curing people of a myriad of terrible conditions and diseases in adults as well as children. (cryo-cell.com)
- Cord blood, what was once seen as medical waste, is now making miracles. (cryo-cell.com)
Marrow1
- 1 Because 2 × 10 8 /kg cells is our usual target for collection during an autologous marrow harvest, those receiving ≤2 × 10 8 /kg nucleated cells may have represented a group of patients with compromised marrow reserve due to either high-risk disease or previous chemotherapy who subsequently had problems during the transplant. (ashpublications.org)
Survival9
- 50% cell survival compared with control) at 10 μ M drug concentration. (nature.com)
- The effect of cell dose on disease-free survival and transplant-related mortality in 85 AML patients allografted in first remission (cell numbers not available for two patients). (ashpublications.org)
- We have also found in a number of different studies that the nucleated cell dose significantly affects transplant-related mortality, 1 , 3-5 survival, 1 , 3 and the speed as well as completeness of hematologic reconstitution after autologous 1 , 6 and allogeneic 3-5 transplantation for hematologic malignancies. (ashpublications.org)
- In multivariate analysis, patients receiving the higher cell dose had a significantly better disease-free survival (relative risk 2.17, P = .045). (ashpublications.org)
- 1 The higher toxic death rate and poorer disease-free survival in patients receiving ≤2 × 10 8 nucleated cells/kg was only partially due to incomplete or delayed hematopoietic reconstitution with resultant increase in bleeding or infections because the cell dose did not affect the probability or rapidity of engraftment significantly in this group of 74 patients. (ashpublications.org)
- Opinions are embraced and defended, but transfusion of red blood cells has not reliably demonstrated increased survival, other than in 2 specific populations, as follows: (1) those with active hemorrhage, and (2) those with active cardiac ischemia. (medscape.com)
- She has been struggling to survive each day but has now reached a point where a stem cell transplant is her only chance at survival. (curriculum-magazine.com)
- However, for patients who cannot be treated with chemotherapy, their only hope of survival is through a blood stem cell transplant. (curriculum-magazine.com)
- Sometimes, the only treatment option for survival of a blood cancer patient is with a blood stem-cell transplant. (curriculum-magazine.com)
Glucose8
- High levels of glucose in the blood 'reprogrammes' stem cells, leading to a lasting increase in the risk of developing dangerous atherosclerosis, according to research funded by the British Heart Foundation published today in Circulation. (ox.ac.uk)
- This finding explains why people with diabetes are at increased risk of heart attack, even after their blood glucose levels are brought back under control, a paradox that has troubled doctors for years. (ox.ac.uk)
- They removed the white blood cells from blood samples and grew them in an environment with normal glucose levels. (ox.ac.uk)
- They also want to find out whether short periods of increased blood glucose in people without diabetes have this damaging effect. (ox.ac.uk)
- The effect of fluoride was studied by adding variable amounts of fluoride (0.i to 10.0mMF) to red cell suspension from normal healthy adult males with 3.75mM D-glucose and measuring the rate of production of lactate and the results are presented in table 1. (fluoridealert.org)
- The activity of the key enzyme of pentose phosphate pathway, glucose-6-phosphate dehydrogenase, was found to be increased by 24% in red cells of these patients compared to controls (Table 2). (fluoridealert.org)
- In unstressed situation, 5 to 10% of the total glucose consumption of human red cells is channeled via HMP shunt (Gaetani et al. (fluoridealert.org)
- Glucose This is a type of sugar that is used to provide energy to cells. (testing.com)
Allogeneic4
- Allogeneic transfusion of whole blood and fractionated blood components remains a controversial topic with respect to transfusion triggers and practices. (medscape.com)
- Technology making the transfusion of allogeneic blood products feasible includes Karl Landsteiner's landmark identification of the human blood groups A, B, and O in 1901. (medscape.com)
- Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
- Quality of life after allogeneic hematopoietic cell transplantation. (bvsalud.org)
Disorders8
- What Are White Blood Cell Disorders? (dana-farber.org)
- Patients with white blood cell disorders are treated at the Blood Disorders Center within the Dana-Farber/Boston Children's Cancer and Blood Disorders Center, where your child will receive care from some of the world's most experienced pediatric hematologists with deep expertise in the conditions they treat. (dana-farber.org)
- What is the latest research on white blood cell disorders? (dana-farber.org)
- The production of specific sub types of cells can also be provided to research groups in order to develop treatments for blood disorders. (ivyroses.com)
- In several hereditary disorders, red blood cells become spherical (in hereditary spherocytosis), oval (in hereditary elliptocytosis), or sickle-shaped (in sickle cell disease). (msdmanuals.com)
- In patients suffering from blood cancer or other blood disorders, they have defects in the blood-forming (hematopoietic) system. (curriculum-magazine.com)
- As per the Globocan 2020 reports, every year over 70 thousand people die of blood cancer and over 1 lakh people are diagnosed with a form of blood cancer of blood disorders in India. (curriculum-magazine.com)
- Sickle Cell Disease (SCD) belongs to a group of inherited red blood cell disorders. (who.int)
Types16
- The presence of circulating tumour cells (CTCs) in the blood of a patient, as found in most forms of epithelial cancer 1 - 5 , has been identified as a reliable indicator of the prognosis of various cancer types. (nature.com)
- The secret of their success is to virtually divide the sample into aliquots (portions) and to search these for the presence or absence of the desired cell types. (nanowerk.com)
- It's clear that these changes occur before the loss of neurons, and it's well known that the types of changes we are seeing certainly injure or kill these types of cells, which are extremely sensitive to their biochemical environment. (news-medical.net)
- In this work, the team showed that the barrier between the blood and the spinal cord weakens in all three types of genetically based ALS cases that involve SOD-1 mutations, allowing toxic substances to flood into the spinal cord and directly affect neurons. (news-medical.net)
- CRISPR-Cas9 technology was being hailed as a revolutionary new approach to gene editing, with many laboratories reporting successful edits in a variety of cell types. (nhsbt.nhs.uk)
- The study included 101 patients who had one of three types of a blood cancer called non-Hodgkin lymphoma, which had not responded to treatment. (advisory.com)
- CD95 counts in the 3 types of white blood cells were significantly higher in PEM infants and showed improvement after nutritional rehabilitation yet not reaching the control values. (who.int)
- Producing HSCs on demand will also provide the opportunity to tailor cells, providing for all blood group types, including rare blood cell groups, removing any immunogenicity or patient rejection and reaction issues. (ivyroses.com)
- Two capillary columns were also run in tandem, separating two blood cell types from a single sample with high purity. (ttu.edu)
- What Are the Blood Types? (kidshealth.org)
- O positive blood is one of the two most common blood types (the other being A positive). (kidshealth.org)
- Along with O positive, it's one of the two most common blood types. (kidshealth.org)
- This blood type has all three types of markers - A, B, and Rh factor. (kidshealth.org)
- Why Are Blood Types Important? (kidshealth.org)
- It also means that you-for some definition of the word you-actually consist of both of the major types of cells: prokaryotic and eukaryotic. (khanacademy.org)
- Other leukemias of specified cell types have been approved for compensation. (yourlawyer.com)
Antibody2
- The spike is really a fantastic protein because it's able to trigger both antibody immune responses and T cell immune responses," says Alba Grifoni, an immunologist at the La Jolla Institute and another coauthor of the new research. (popsci.com)
- Several aspects of the OT-CAC method were studied, such as the affinity of one antibody between two different cell lines, the effect of shear force, and the recovery of captured cells. (ttu.edu)
Cancer26
- Cancer spreads when cells from primary tumors break off and travel through the bloodstream and lymph system, settling in new areas of the body and forming secondary tumors. (ieee.org)
- If that kind of thing feels good to you, imagine how satisfying it would be to point this laser at your loved one ' s cancer cells. (ieee.org)
- Nanowerk News ) Even in the early stages of cancer, individual cancer cells can be found in the blood. (nanowerk.com)
- Experiments with blood containing a known number of breast cancer cells yielded a recovery rate of 93 % and a false positive rate of zero. (nanowerk.com)
- Conn Hastings received a PhD from the Royal College of Surgeons in Ireland for his work in drug delivery, investigating the potential of injectable hydrogels to deliver cells, drugs and nanoparticles in the treatment of cancer and cardiovascular diseases. (medgadget.com)
- The cure for blood cancer is in the hands of ordinary people. (bethematch.org)
- Every three minutes, someone is diagnosed with a blood cancer like leukemia. (bethematch.org)
- Supporting previous studies, patients with blood cancer were more likely to die from COVID-19 than patients with solid tumors or without cancer. (newswise.com)
- Out of 100 patients admitted to Penn Medicine hospitals, 22 had a blood cancer diagnosis and were 2.6 fold more likely to die compared to patients with solid cancer, the authors found. (newswise.com)
- Many screening approaches for identification of new cancer drug candidates have utilized cell-free assays for detection of specific interactions with known or emerging molecular targets. (nature.com)
- This work suggests that some putative cancer stem cells promote cancer growth both directly and indirectly, and may explain the failure of certain anti-angiogenic cancer drugs and aid the design of new therapies. (natureasia.com)
- A low white blood cell count can be caused by many health conditions including infections, autoimmune diseases (such as lupus and rheumatoid arthritis), or be a side effect of cancer treatment. (xshotpix.com)
- The cells were then modified to contain a gene that fights cancer-turning the cells into "cancer killers," according to AP -and reintroduced into patients' bloodstreams. (advisory.com)
- Most AML subtypes are based on how mature (developed) the cancer cells are at the time of diagnosis and how different they are from normal cells. (cancer.gov)
- Agilent's companion diagnostic for Mirati's non-small cell lung cancer treatment Krazati will be available through Quest's national healthcare network. (genomeweb.com)
- FoundationOne Liquid CDx , a liquid biopsy test, is the only blood-based CDx approved for the targeted cancer therapy. (genomeweb.com)
- Every 5 minutes, someone in India is diagnosed with blood cancer and many of them children and young people. (curriculum-magazine.com)
- Kriti, a 22-year-old girl who was diagnosed with blood cancer when she was 12-year-old and is on medication for the last 10 years. (curriculum-magazine.com)
- What is blood cancer and its incidence in India? (curriculum-magazine.com)
- Blood cancer refers to defects in the blood-forming system, which cause cancer cells to enter the bloodstream and multiply uncontrollably, crowding out the healthy cells. (curriculum-magazine.com)
- Most often blood cancer can be treated by administering chemotherapy. (curriculum-magazine.com)
- ABRAXANE ® is a prescription medicine used to treat advanced non-small cell lung cancer, in combination with carboplatin, in people who cannot be treated with surgery or radiation. (abraxane.com)
- Women who have a close blood relative with breast cancer are also at greater risk. (abraxane.com)
- Vaccines made from survivin peptide may help the body build an effective immune response to kill cancer cells that express survivin. (clinicaltrials.gov)
- Lenalidomide may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. (clinicaltrials.gov)
- Separating circulating cancer cells from blood cells for diagnostic, prognostic and treatment purposes may become much easier using an acoustic separation method and an inexpensive, disposable chip, according to a team of engineers. (engineeringchallenges.org)
Flow cytometry1
- This volume percentage hematocrit is measured by centrifuge or flow cytometry and is 45% of cells to total volume in males and 40% in females. (wn.com)
Leukemia2
- The leukemia cells can spread outside the blood to other parts of the body, including the central nervous system (brain and spinal cord ), skin, and gums . (cancer.gov)
- Chimeric antigen receptor ( CAR ) T cell therapy targeting T-cell acute lymphoblastic leukemia ( T-ALL ) faces limitations such as antigen selection and limited T-cell persistence. (bvsalud.org)
White Bloo15
- My white blood cell counts are too low! (cancer.org)
- My white blood cell counts stayed high for a chemo patient. (cancer.org)
- What Is a Normal White Blood Cell Count for a Female? (reference.com)
- The normal white blood cell count for a female is between 3.5 and 10.5 billion cells per liter, as stated by Mayo Clinic. (reference.com)
- We found that the patients with atopic dermatitis had significantly higher white blood cell counts, neutrophil counts, lymphocyte counts, NLR, eosinophil counts, and PLT than the healthy controls (Table 1), but there were no statistically significant differences between PLR, RDW, MPV, and RPR of patients and controls. (xshotpix.com)
- Can allergies lower white blood cell count? (xshotpix.com)
- That's why a high white blood cell count usually requires further investigation. (xshotpix.com)
- What causes a low white blood cell count? (xshotpix.com)
- What should your white blood cell count be? (xshotpix.com)
- A white blood cell count of less than 4,000 cells per microliter of blood is considered low. (xshotpix.com)
- Can you have leukopenia if your white blood cell count is low? (xshotpix.com)
- A team of scientists from the Max Planck Institute for Intelligent Systems (MPI-IS) in Stuttgart invented a tiny micro-robot that resembles a white blood cell traveling through the circulatory system. (techxplore.com)
- A lymphoid stem cell becomes a white blood cell . (cancer.gov)
- In AML, the myeloid stem cells usually become a type of immature white blood cell called myeloblasts (or myeloid blasts ). (cancer.gov)
- The PML-RARA gene sends a message that stops promyelocytes (a type of white blood cell) from maturing. (cancer.gov)
Detect5
- It could thus be quite informative to detect these cells in the blood and examine them more closely. (nanowerk.com)
- This method supports surgeons to detect blood flow anomalies that occur during surgery. (zeiss.de)
- They used whole-exome sequencing to detect CHIP in peripheral blood cells and then linked that presence with CHD among participants of four case-control studies, for a total of 4726 patients with CHD and 3529 controls. (medscape.com)
- Several attempts have been made to detect and retrieve fetal nucleated cells including nucleated erythrocytes (NRBCs), leucocytes and trophoblasts in maternal blood. (who.int)
- and yet another is the need to create inexpensive and rapid diagnostic devices such as gene chips and sensors able to detect minute amounts of chemicals in the blood. (engineeringchallenges.org)
CTCs1
- Melanoma CTCs absorb more of this energy than normal cells, causing them to heat up quickly and expand. (ieee.org)
Transplantation2
- 1 The number of nucleated cells infused during transplantation is a variable which is usually controllable. (ashpublications.org)
- To the best of our knowledge, only the transmission of malarial parasites has been reported during stem cell transplantation. (cdc.gov)
Microliter1
- Note: cells/mcl = cells per microliter). (medlineplus.gov)
Transfusion medicine3
- In recent years, the field of transfusion medicine has seen increased study of cell-derived microparticles (MPs). (medscape.com)
- Blood banks around the world store blood components for several weeks ensuring its availability for transfusion medicine. (plos.org)
- The long term storage of blood components is essential in transfusion medicine. (plos.org)
Haematopoietic2
- A blood cell , also called a haematopoietic cell , hemocyte , or hematocyte , is a cell produced through hematopoiesis and found mainly in the blood . (wn.com)
- Studies on signalling pathways that govern haematopoietic stem cell (HSC) self-renewal and fate decisions are critical to understand how a balanced array of progenies is produced on a daily basis to maintain homeostasis of the blood system and how this balance is skewed during disease formation such as Leukaemia. (cardiff.ac.uk)