Blood Cell Count: The number of LEUKOCYTES and ERYTHROCYTES per unit volume in a sample of venous BLOOD. A complete blood count (CBC) also includes measurement of the HEMOGLOBIN; HEMATOCRIT; and ERYTHROCYTE INDICES.Leukocyte Count: The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.Erythrocyte Count: The number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.Cell Count: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.Blood Cells: The cells found in the body fluid circulating throughout the CARDIOVASCULAR SYSTEM.CD4 Lymphocyte Count: The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.Platelet Count: The number of PLATELETS per unit volume in a sample of venous BLOOD.Leukocytosis: A transient increase in the number of leukocytes in a body fluid.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Hematologic Tests: Tests used in the analysis of the hemic system.Hematocrit: The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Hemoglobins: The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.Lymphocyte Count: The number of LYMPHOCYTES per unit volume of BLOOD.Leukocytes: White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).Erythrocyte Indices: ERYTHROCYTE size and HEMOGLOBIN content or concentration, usually derived from ERYTHROCYTE COUNT; BLOOD hemoglobin concentration; and HEMATOCRIT. The indices include the mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC).Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.C-Reactive Protein: A plasma protein that circulates in increased amounts during inflammation and after tissue damage.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Viral Load: The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Leukemoid Reaction: A peripheral blood picture resembling that of leukemia or indistinguishable from it on the basis of morphologic appearance alone. (Dorland, 27th ed)Reticulocyte Count: The number of RETICULOCYTES per unit volume of BLOOD. The values are expressed as a percentage of the ERYTHROCYTE COUNT or in the form of an index ("corrected reticulocyte index"), which attempts to account for the number of circulating erythrocytes.LeukopeniaBone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Anti-HIV Agents: Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.Blood Sedimentation: Measurement of rate of settling of erythrocytes in anticoagulated blood.Cerebrospinal Fluid: A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.Hematology: A subspecialty of internal medicine concerned with morphology, physiology, and pathology of the blood and blood-forming tissues.Spinal Puncture: Tapping fluid from the subarachnoid space in the lumbar region, usually between the third and fourth lumbar vertebrae.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Blood Chemical Analysis: An examination of chemicals in the blood.Antiretroviral Therapy, Highly Active: Drug regimens, for patients with HIV INFECTIONS, that aggressively suppress HIV replication. The regimens usually involve administration of three or more different drugs including a protease inhibitor.Acute Disease: Disease having a short and relatively severe course.Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.HIV-1: The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.Hematopoiesis: The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).Thrombocytopenia: A subnormal level of BLOOD PLATELETS.Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.Erythrocyte Transfusion: The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.Anemia: A reduction in the number of circulating ERYTHROCYTES or in the quantity of HEMOGLOBIN.Colony Count, Microbial: Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.Cytogenetics: A subdiscipline of genetics which deals with the cytological and molecular analysis of the CHROMOSOMES, and location of the GENES on chromosomes, and the movements of chromosomes during the CELL CYCLE.Infant, Newborn: An infant during the first month after birth.Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.Solar Activity: Any type of variation in the appearance of energy output of the sun. (NASA Thesaurus, 1994)Capillary Fragility: The susceptibility of CAPILLARIES, under conditions of increased stress, to leakage.Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.Appendicitis: Acute inflammation of the APPENDIX. Acute appendicitis is classified as simple, gangrenous, or perforated.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Erythrocyte Membrane: The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.Erythrocyte Deformability: Ability of ERYTHROCYTES to change shape as they pass through narrow spaces, such as the microvasculature.Hematopoietic Stem Cells: Progenitor cells from which all blood cells derive.Granulocyte Colony-Stimulating Factor: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Cross-Sectional Studies: Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.AIDS-Related Opportunistic Infections: Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.Spleen: An encapsulated lymphatic organ through which venous blood filters.Granulocytes: Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.ROC Curve: A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Reference Values: The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.fms-Like Tyrosine Kinase 3: A receptor tyrosine kinase that is involved in HEMATOPOIESIS. It is closely related to FMS PROTO-ONCOGENE PROTEIN and is commonly mutated in acute MYELOID LEUKEMIA.JapanAnti-Retroviral Agents: Agents used to treat RETROVIRIDAE INFECTIONS.Anemia, Sickle Cell: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.Splenomegaly: Enlargement of the spleen.Hypersplenism: Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.Erythropoiesis: The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Mastitis, Bovine: INFLAMMATION of the UDDER in cows.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Interleukin-6: A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Hematologic Diseases: Disorders of the blood and blood forming tissues.Pancytopenia: Deficiency of all three cell elements of the blood, erythrocytes, leukocytes and platelets.Bacterial Infections: Infections by bacteria, general or unspecified.Calcitonin: A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.Cytarabine: A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Peritonitis: INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.Splenectomy: Surgical procedure involving either partial or entire removal of the spleen.Blast Crisis: An advanced phase of chronic myelogenous leukemia, characterized by a rapid increase in the proportion of immature white blood cells (blasts) in the blood and bone marrow to greater than 30%.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Milk: The white liquid secreted by the mammary glands. It contains proteins, sugar, lipids, vitamins, and minerals.Recurrence: The return of a sign, symptom, or disease after a remission.Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.Blood Preservation: The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).Erythroblasts: Immature, nucleated ERYTHROCYTES occupying the stage of ERYTHROPOIESIS that follows formation of ERYTHROID PRECURSOR CELLS and precedes formation of RETICULOCYTES. The normal series is called normoblasts. Cells called MEGALOBLASTS are a pathologic series of erythroblasts.Erythrocyte Aggregation: The formation of clumps of RED BLOOD CELLS under low or non-flow conditions, resulting from the attraction forces between the red blood cells. The cells adhere to each other in rouleaux aggregates. Slight mechanical force, such as occurs in the circulation, is enough to disperse these aggregates. Stronger or weaker than normal aggregation may result from a variety of effects in the ERYTHROCYTE MEMBRANE or in BLOOD PLASMA. The degree of aggregation is affected by ERYTHROCYTE DEFORMABILITY, erythrocyte membrane sialylation, masking of negative surface charge by plasma proteins, etc. BLOOD VISCOSITY and the ERYTHROCYTE SEDIMENTATION RATE are affected by the amount of erythrocyte aggregation and are parameters used to measure the aggregation.Duffy Blood-Group System: A blood group consisting mainly of the antigens Fy(a) and Fy(b), determined by allelic genes, the frequency of which varies profoundly in different human groups; amorphic genes are common.Eosinophils: Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Immunophenotyping: Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.6-Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.Erythropoietin: Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.Prothrombin Time: Clotting time of PLASMA recalcified in the presence of excess TISSUE THROMBOPLASTIN. Factors measured are FIBRINOGEN; PROTHROMBIN; FACTOR V; FACTOR VII; and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS.Sperm Count: A count of SPERM in the ejaculum, expressed as number per milliliter.Erythrocyte Aging: The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Statistics, Nonparametric: A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)HIV Seropositivity: Development of neutralizing antibodies in individuals who have been exposed to the human immunodeficiency virus (HIV/HTLV-III/LAV).Asparaginase: A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.CD4-CD8 Ratio: Ratio of T-LYMPHOCYTES that express the CD4 ANTIGEN to those that express the CD8 ANTIGEN. This value is commonly assessed in the diagnosis and staging of diseases affecting the IMMUNE SYSTEM including HIV INFECTIONS.Fibrin Fibrinogen Degradation Products: Soluble protein fragments formed by the proteolytic action of plasmin on fibrin or fibrinogen. FDP and their complexes profoundly impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinolysis.Linear Models: Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.Meningitis, Bacterial: Bacterial infections of the leptomeninges and subarachnoid space, frequently involving the cerebral cortex, cranial nerves, cerebral blood vessels, spinal cord, and nerve roots.Polycythemia Vera: A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.Hypereosinophilic Syndrome: A heterogeneous group of disorders with the common feature of prolonged eosinophilia of unknown cause and associated organ system dysfunction, including the heart, central nervous system, kidneys, lungs, gastrointestinal tract, and skin. There is a massive increase in the number of EOSINOPHILS in the blood, mimicking leukemia, and extensive eosinophilic infiltration of the various organs.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Ethylene Glycols: An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Infant, Newborn, Diseases: Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Sputum: Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.Pneumonia: Infection of the lung often accompanied by inflammation.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Primary Myelofibrosis: A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.Neopterin: A pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a precursor in the biosynthesis of biopterin.Smoking: Inhaling and exhaling the smoke of burning TOBACCO.Pleural Effusion: Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.Eosinophilia: Abnormal increase of EOSINOPHILS in the blood, tissues or organs.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Blood: The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Idarubicin: An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Meningitis: Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)Colony-Forming Units Assay: A cytologic technique for measuring the functional capacity of stem cells by assaying their activity.Alanine Transaminase: An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.Random Allocation: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.Infection: Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Precursor B-Cell Lymphoblastic Leukemia-Lymphoma: A leukemia/lymphoma found predominately in children and adolescents and characterized by a high number of lymphoblasts and solid tumor lesions. Frequent sites involve LYMPH NODES, skin, and bones. It most commonly presents as leukemia.Monocytes: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Body Temperature: The measure of the level of heat of a human or animal.Erythrocyte Volume: Volume of circulating ERYTHROCYTES . It is usually measured by RADIOISOTOPE DILUTION TECHNIQUE.Mice, Inbred C57BLHIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2.Longitudinal Studies: Studies in which variables relating to an individual or group of individuals are assessed over a period of time.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Myeloproliferative Disorders: Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.Serum Albumin: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Aspartate Aminotransferases: Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Bronchoalveolar Lavage Fluid: Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Sheep: Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Immune System: The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components.Blood Coagulation: The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.Organ Size: The measurement of an organ in volume, mass, or heaviness.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Fetal Blood: Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.Ferritins: Iron-containing proteins that are widely distributed in animals, plants, and microorganisms. Their major function is to store IRON in a nontoxic bioavailable form. Each ferritin molecule consists of ferric iron in a hollow protein shell (APOFERRITINS) made of 24 subunits of various sequences depending on the species and tissue types.Treatment Failure: A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.Hemostasis: The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION.Karyotyping: Mapping of the KARYOTYPE of a cell.Acute-Phase Proteins: Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.Iron: A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Inflammation Mediators: The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).Odds Ratio: The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Whole-Body Irradiation: Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.

Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. (1/1848)

We examined the role of the interleukin-8 (IL-8) receptor in a murine model of allergen-induced pulmonary inflammation using mice with a targeted deletion of the murine IL-8 receptor homologue (IL-8r-/-). Wild-type (Wt) and IL-8r-/- mice were systemically immunized to ovalbumin (OVA) and were exposed with either single or multiple challenge of aerosolized phosphate-buffered saline (OVA/PBS) or OVA (OVA/OVA). Analysis of cells recovered from bronchoalveolar lavage (BAL) revealed a diminished recruitment of neutrophils to the airway lumen after single challenge in IL-8r-/- mice compared with Wt mice, whereas multiply challenged IL-8r-/- mice had increased B cells and fewer neutrophils compared with Wt mice. Both Wt and IL-8r-/- OVA/OVA mice recruited similar numbers of eosinophils to the BAL fluid and exhibited comparable degrees of pulmonary inflammation histologically. Both total and OVA-specific IgE levels were greater in multiply challenged IL-8r-/- OVA/OVA mice than in Wt mice. Both the IL-8r-/- OVA/OVA and OVA/PBS mice were significantly less responsive to methacholine than their respective Wt groups, but both Wt and IL-8r mice showed similar degrees of enhancement after multiple allergen challenge. The data demonstrate that the IL-8r modulates IgE production, airway responsiveness, and the composition of the cells (B cells and neutrophils) recruited to the airway lumen in response to antigen.  (+info)

Relative efficacy of 32P and 89Sr in palliation in skeletal metastases. (2/1848)

32p and 89Sr have been shown to produce significant pain relief in patients with skeletal metastases from advanced cancer. Clinically significant pancytopenia has not been reported in doses up to 12 mCi (444 MBq) of either radionuclide. To date, no reports comparing the relative efficacy and toxicity of the two radionuclides in comparable patient populations have been available. Although a cure has not been reported, both treatments have achieved substantial pain relief. However, several studies have used semiquantitative measures such as "slight," "fair," "partial" and "dramatic" responses, which lend themselves to subjective bias. This report examines the responses to treatment with 32P or 89Sr by attempting a quantification of pain relief and quality of life using the patients as their own controls and compares toxicity in terms of hematological parameters. METHODS: Thirty-one patients with skeletal metastases were treated for pain relief with either 32P (16 patients) or 89Sr (15 patients). Inclusion criteria were pain from bone scan-positive sites above a subjective score of 5 of 10 despite analgesic therapy with narcotic or non-narcotic medication, limitation of movement related to the performance of routine daily activity and a predicted life expectancy of at least 4 mo. The patients had not had chemotherapy or radiotherapy during the previous 6 wk and had normal serum creatinine, white cell and platelet counts. 32P was given orally as a 12 mCi dose, and 89Sr was given intravenously as a 4 mCi (148 MBq) dose. The patients were monitored for 4 mo. RESULTS: Complete absence of pain was seen in 7 of 16 patients who were given 32P and in 7 of 15 patients who were given 89Sr. Pain scores fell by at least 50% of the pretreatment score in 14 of 16 patients who were given 32P and 14 of 15 patients who were given 89Sr. Mean duration of pain relief was 9.6 wk with 32P and 10 wk with 89Sr. Analgesic scores fell along with the drop in pain scores. A fall in total white cell, absolute granulocyte and platelet counts occurred in all patients. Subnormal values of white cells and platelets were seen in 5 and 7 patients, respectively, with 32P, and in 0 and 4 patients, respectively, after 89Sr therapy. The decrease in platelet count (but not absolute granulocyte count) was statistically significant when 32P patients were compared with 89Sr patients. However, in no instance did the fall in blood counts require treatment. Absolute granulocyte counts did not fall below 1000 in any patient. There was no significant difference between the two treatments in terms of either efficacy or toxicity. CONCLUSION: No justification has been found in this study for the recommendation of 89Sr over the considerably less expensive oral 32P for the palliation of skeletal pain from metastases of advanced cancer.  (+info)

The minimum CD34 threshold depends on prior chemotherapy in autologous peripheral blood stem cell recipients. (3/1848)

We analysed 57 patients with non-myeloid malignancies who received a non-purged autologous PBSCT. All had similar mobilisation and conditioning regimens. A high prior chemotherapy score and the number of chemotherapy lines used (P = 0.015 and P = 0.01, respectively) were adverse predictors of CD34 cell yields. Lower CD34 values (P = 0.002) were seen in patients treated with potent stem cell toxins (BCNU, melphalan, CCNU and mustine), designated toxicity factor 4 agents (TF4). All patients infused with grafts containing CD34 cell doses between 1.0 and 2.0 x 10(6)/kg (range 1.25-1.90) engrafted by day 51. The only variable associated with slow platelet recovery was exposure to TF4 (P = 0.007). The majority of patients with CD34 >1.0 x 10(6)/kg achieved rapid and sustained engraftment and the only predictive factor of delayed recovery is prior exposure to stem cell toxins. Potential PBSCT candidates should if possible avoid first line and salvage chemotherapy containing TF4 drugs. We therefore advocate a minimum CD34 threshold of >1.0 x 10(6)/kg in patients without extensive prior chemoradiotherapy, and > or = 2.0 x 10(6)/kg in all other patients.  (+info)

A technique for dual determination of cytotoxic and helper lymphocyte precursor frequency by a miniaturized dye release method. (4/1848)

Helper (HTLPf) and cytotoxic (CTLPf) lymphocyte precursor frequency assays are increasingly used in bone marrow stem cell and organ transplant compatibility testing. Current techniques require large cell numbers and radioisotopes. To improve the technique, we developed a miniaturized fluorescent read-out combined HTLPf/CTLPf limiting dilution assay. The assay requires only 5 x 10(6) stimulators, 2 x 10(6) responders and 0.24 x 10(6) target cells in Terasaki plates (40 microl/well). For the HTLPf, culture supernatants from each well were assayed for IL-2 production. The IL-2-dependent proliferation of the mouse 9.12 cell line was detected by a semi-automated fluorescent dye technique. After addition of rhIL-2 (recombinant human IL-2) on days 3 and 7, CTLPs were detected on day 10 by measuring the lysis of dye-labeled targets. Results were comparable to standard radioisotope-based techniques. The assay had a coefficient of variation of approximately 30%. The assay detected helper CD4 cells, pure cytotoxic CD8, helper CD8 cells and helper/cytotoxic CD8 cells. Discrimination was demonstrated between HLA-matched related and non-related pairs. The ease of testing and small cell numbers required should facilitate further evaluation of HTLPf and CTLPf for compatibility testing in unrelated donor transplantation and monitoring immune responses following adoptive transfer of lymphocytes.  (+info)

Effects of isoproterenol on myocardial structure and function in septic rats. (5/1848)

In this study we sought to determine the effect of sepsis on two sequelae of prolonged (24-h) beta-agonist administration, myocardial hypertrophy and catecholamine-induced cardiotoxicity. Sprague-Dawley rats were randomized to cecal ligation and perforation (CLP) or sham study groups and then further randomized to receive isoproterenol (2.4 mg. kg-1. day-1 iv) or placebo treatment. At 24 h, myocardial function was assessed by using the Langendorff isolated-heart technique or the heart processed for plain light microscopy. We found that 1) sepsis reduced contractile function, indicated by a rightward shift in the Starling curve (ANOVA with repeated measures, sepsis effect, P < 0.002); 2) sepsis-induced myocardial depression was reversed by isoproterenol treatment (isoproterenol effect, P < 0.0001); 3) sepsis reduced, but did not block, isoproterenol-induced myocardial hypertrophy (isoproterenol effect, P < 0.0001); 4) sepsis did not protect the heart from catecholamine-induced tissue injury; 5) the septic heart was protected against the effects of ischemiareperfusion (decreased postreperfusion resting tension, ANOVA with repeated measures, P < 0.01), an effect attenuated by isoproterenol treatment (P < 0.005); and 6) sepsis reduced the incidence of sustained asystole or ventricular fibrillation after ischemia-reperfusion (P < 0.05), an effect also attenuated by isoproterenol treatment (P < 0.01). We conclude that, in sepsis, beta-agonists induce changes in myocardial weight and function consistent with acute myocardial hypertrophy. These changes occur at the expense of significant tissue injury and increased sensitivity to ischemia-reperfusion-induced tissue injury.  (+info)

Phase I and pharmacologic study of the combination of paclitaxel, cisplatin, and topotecan administered intravenously every 21 days as first-line therapy in patients with advanced ovarian cancer. (6/1848)

PURPOSE: To evaluate the feasibility of administering topotecan in combination with paclitaxel and cisplatin without and with granulocyte colony-stimulating factor (G-CSF) support as first-line chemotherapy in women with incompletely resected stage III and stage IV ovarian carcinoma. PATIENTS AND METHODS: Starting doses were paclitaxel 110 mg/m2 administered over 24 hours (day 1), followed by cisplatin 50 mg/m2 over 3 hours (day 2) and topotecan 0.3 mg/m2/d over 30 minutes for 5 consecutive days (days 2 to 6). Treatment was repeated every 3 weeks. After encountering dose-limiting toxicities (DLTs) without G-CSF support, the maximum-tolerated dose was defined as 5 microg/kg of G-CSF subcutaneously starting on day 6. RESULTS: Twenty-one patients received a total of 116 courses at four different dose levels. The DLT was neutropenia. At the first dose level, all six patients experienced grade 4 myelosuppression. G-CSF support permitted further dose escalation of cisplatin and topotecan. Nonhematologic toxicities, primarily fatigue, nausea/vomiting, and neurosensory neuropathy, were observed but were generally mild. Of 15 patients assessable for response, nine had a complete response, four achieved a partial response, and two had stable disease. CONCLUSION: Neutropenia was the DLT of this combination of paclitaxel, cisplatin, and topotecan. The recommended phase II dose is paclitaxel 110 mg/m2 (day 1), followed by cisplatin 75 mg/m2 (day 2) and topotecan 0.3 mg/m2/d (days 2 to 6) with G-CSF support repeated every 3 weeks.  (+info)

Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. (7/1848)

Platelet/endothelial cell adhesion molecule-1 (PECAM-1; CD31), a member of the Ig superfamily, is expressed strongly at endothelial cell-cell junctions, on platelets, and on most leukocytes. CD31 has been postulated to play a role in vasculogenesis and angiogenesis, and has been implicated as a key mediator of the transendothelial migration of leukocytes. To further define the physiologic role of CD31, we used targeted gene disruption of the CD31 gene in embryonic stem cells to generate CD31-deficient mice. CD31-deficient mice (CD31KO) are viable and born at the expected Mendelian frequency, remain healthy, and exhibit no obvious vascular developmental defects. In response to inflammatory challenge, polymorphonuclear leukocytes of CD31KO mice are arrested between the vascular endothelium and the basement membrane of inflammatory site mesenteric microvessels, confirming a role for CD31 in the migration of neutrophils through the subendothelial extracellular matrix. Normal numbers of leukocytes are recovered from inflammatory sites in CD31KO mice, however, suggesting that the defect in leukocyte migration across basal lamina observed in the absence of CD31 may be compensated for by the use of other adhesion molecules, or possibly an increased rate of migration. Homing of T lymphocytes in vivo is normal, and CD31KO mice are able to mount a cutaneous hypersensitivity response normally. In addition, CD31-mediated homophilic adhesion does not appear to play a role in platelet aggregation in vitro. This study provides genetic evidence that CD31 is involved in transbasement membrane migration, but does not play an obligatory role in either vascular development or leukocyte migration.  (+info)

Single leukapheresis products collected from healthy donors after the administration of granulocyte colony-stimulating factor contain ten-fold higher numbers of long-term reconstituting hematopoietic progenitor cells than conventional bone marrow allografts. (8/1848)

Cytokine-mobilized peripheral blood progenitor cells (PBPCs) have been used successfully for hematopoietic reconstitution following allogeneic transplantation. The ease of harvest, the faster engraftment and the high yield of CD34+ cells have made this source of hematopoietic progenitor cells (HPCs) an attractive alternative to bone marrow (BM). In the present study we compared the engraftment potential of conventional BM allografts and single leukapheresis products (LPs) collected from healthy donors following the administration of granulocyte colony-stimulating factor (G-CSF). For this, lineage-committed and primitive HPCs were assessed by flow cytometry and by colony- and cobblestone area-forming cell (CFC, CAFC) assays. Mean numbers of CD34+ cells in LPs (n = 11) were similar to that of BM grafts (n = 12) (278+/-57 vs 227+/-34 x 10(6) CD34+ cells). The frequencies of CFCs, week 5 CAFCs and week 8 CAFCs were 1.6-, 8.4- and 10.3-fold higher in the CD34+ compartment of mobilized blood than that of marrow, resulting in significantly higher yields of clonogenic HPCs in LPs when compared to BM grafts. We conclude that G-CSF preferentially mobilizes clonogenic progenitors capable of short- and, in particular, longterm reconstitution, and that the engraftment potential of single LPs is superior to that of BM allografts. Hence, the use of PBPCs may be favorable for protocols that include graft manipulations with expected cell loss (eg T cell depletion, CD34+ selection). PBPCs may also be advantageous for gene therapy trials due to their high numbers of potential target cells (eg CAFCs).  (+info)

*APACHE II

White blood cell count. *Glasgow Coma Scale. These were measured during the first 24 hours after admission, and utilized in ...

*Pericoronitis

Pyrexia (fever). Leukocytosis (increased white blood cell count). Malaise (general feeling of being unwell). Loss of appetite. ...

*Kocher criteria

C White blood cell count > 12,000 Wheeless Online Kocher Criteria Online Smith, Howard S. (2009). Current Therapy in Pain. ...

*Toxic megacolon

White blood cell count is usually elevated. Severe sepsis may present with hypothermia or leukopenia. The objective of ... There is relative destruction of the ganglion cells and swelling of the nerve fibres in the myenteric plexus, with concomitant ...

*Lymphoma in animals

Lymphoma in the bone marrow causes anemia, low platelet count, and low white blood cell count. Biopsy of affected lymph nodes ... but white blood cell counts must be monitored. Allogeneic and autologous stem cell transplantations (as is commonly done in ... The white blood cell count must be monitored. Prednisone used alone can work very well for weeks to months, but it may cause ... The white blood cell count must be monitored. Remission and survival times are comparable to dogs. Lower stage lymphoma has a ...

*Cytopenia

It takes a number of forms: Low red blood cell count: resulting in anemia. Low white blood cell count: leukopenia or ... Low granulocyte count: granulocytopenia Low red blood cell, white blood cell, and platelet counts: pancytopenia. Polycythemia, ... Cytopenia is a reduction in the number of mature blood cells. ... Because neutrophils make up at least half of all white cells, ... they are almost always low in leukopenia[citation needed]. Low platelet count: thrombocytopenia. ...

*Calcium pyrophosphate dihydrate crystal deposition disease

The white blood cell count is often raised. The arthritis is usually polyarticular (i.e., it leads to an inflammation of ...

*Ranson criteria

John Ranson (1938-1995). At admission: Age in years > 55 years WBC count > 16000 cells/mm3 Blood glucose > 11 mmol/L (> 200 mg/ ...

*Acute prostatitis

A complete blood count reveals increased white blood cells. Sepsis from prostatitis is very rare, but may occur in ... as evidenced by white blood cells and bacteria in the urine. Acute prostatitis may be a complication of prostate biopsy. Often ... The organism may be found in blood or urine, and sometimes in both. Common bacteria are Escherichia coli, Klebsiella, Proteus, ... penetration of the prostate is not as important as for category II because the intense inflammation disrupts the prostate-blood ...

*Septic arthritis

... the typical white blood cell count in septic arthritis is over 50,000-100,000 cells per 10−6/l (50,000-100,000 cell/mm3). ... Other studies such as blood cultures, white blood cell count with differential, ESR, and CRP should also be included. However, ... Laboratory testing includes white blood cell count, ESR, and CRP. These values are usually elevated in those with septic ... However, septic synovial fluid can have white blood cell counts as low as a few thousand in the early stages. Therefore, ...

*Cerebrospinal fluid

CSF is normally free of red blood cells, and at most contains only a few white blood cells. Any white blood cell count higher ... and counting and identifying white and red blood cells within the fluid; measuring protein and glucose levels; and culturing ... Unlike blood passing from the capillaries into the choroid plexus, the epithelial cells lining the choroid plexus contain tight ... The presence of red blood cells and xanthochromia may indicate subarachnoid hemorrhage; whereas central nervous system ...

*Autosplenectomy

doi:10.1016/s0140-6736(10)61493-6. "Red Blood Cell Pit Count". Red Blood Cell Lab. Children's Hospital Oakland Research ... One of the spleen's main tasks is to filter the blood and remove and recycle damaged or old red blood cells. Splenic function ... Autosplenectomy can occur in cases of sickle-cell disease where the misshapen cells block blood flow to the spleen, causing ... Howell-Jolly bodies are found on red blood cells and contain chromatin remnants from basophilic cells. Under normal conditions ...

*Pyometra

Bloodwork may show dehydration and/or increased white blood cell count. X-rays will show an enlarged uterus, and ultrasound ... Höglund, Odd Viking; Lövebrant, Johanna; Olsson, Ulf; Höglund, Katja (17 November 2016). "Blood pressure and heart rate during ...

*HBB

Carriers of this mutation show an enhanced red blood cell count. As a curiosity, the same mutation was also associated to a ... This further causes clumping of HbS molecules into rigid fibers, causing "sickling" of the entire red blood cells in the ... Cell. 122 (6): 957-968. doi:10.1016/j.cell.2005.08.029. PMID 16169070. Shaanan B (1983). "Structure of human oxyhaemoglobin at ... The most common is HbS, which causes sickle cell disease. HbS is produced by a point mutation in HBB in which the codon GAG is ...

*GIT2

Mutant male mice had a decrease in white blood cell count. An increased thickness in hippocampus was observed. Mutant female ... Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9-13. doi:10.1016/j.cell.2006.12.018. PMID ... Ku GM, Yablonski D, Manser E, Lim L, Weiss A (Feb 2001). "A PAK1-PIX-PKL complex is activated by the T-cell receptor ... The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA ...

*NPU terminology

Erythrocyte cell count in patient blood NPU01960 Blood-Erythrocytes; number concentration = ? x 1012 per litre Concentration of ... BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS." Example 2: The reference for 'Glycoprotein hormones alpha chain' ... Example 1: In the items listed above, the reference for 'Blood' is 'Medical Subject Headings database (MESH), ID D001769' which ... blood plasma, pituitary gland, skin, kidney, whole body) The component - the specific part or process that is of interest in ...

*Darrin Winston

Winston had a very low white and red blood cell count. He ruptured his spleen, did not have enough cells to fight it, and died ...

*Pleocytosis

It is often defined specifically as an increased white blood cell count in cerebrospinal fluid. Increased white blood cell ... pleocytosis is an increased cell count (from Greek pleion, "more"), particularly an increase in white blood cell count, in a ... count in the blood is called leukocytosis. TheFreeDictionary > pleocytosis Citing: The American Heritage Medical Dictionary, ...

*Ascariasis

White blood cells counts may demonstrate peripheral eosinophilia; this is common in many parasitic infections and is not ... The eggs hatch in the intestines, burrow through the gut wall, and migrate to the lungs via the blood. There they break into ... a transient respiratory illness associated with blood eosinophilia and pulmonary infiltrates with radiographic shadowing. The ...

*Flucytosine

Blood cell counts should be taken very frequently. Patients with renal disease should receive flucytosine cautiously and in ...

*Ernst Abbe

1878). "Über Blutkörper-Zählung" [About Counting Blood Cells]. Jenaische Zeitschrift für Naturwissenschaft (in German). Jena, ...

*Amoebiasis

An increased white blood cell count may be present in severe cases. The most accurate test is finding specific antibodies in ... Entamoeba histolytica ingests the destroyed cells by phagocytosis and is often seen with red blood cells (a process known as ... Symptoms can range from mild diarrhea to severe dysentery with blood and mucus. The blood comes from lesions formed by the ... People affected may develop anemia due to loss of blood. Cysts of Entamoeba can survive for up to a month in soil or for up to ...

*Gaffkaemia

... but continue to survive within the blood cells, feeding on the cytoplasm. The lobster's blood cell count drops, and the ... They may be engulfed by phagocytosis into the lobster's blood cells, ... In a severe infection, the ability of the lobster's blood pigment haemocyanin to carry oxygen may be reduced by up to 50%. The ... The stores of glycogen in the hepatopancreas become depleted, concentrations of glucose and lactic acid in the blood drop, and ...

*Lamotrigine

... has been associated with a decrease in white blood cell count (leukopenia).[40] Lamotrigine does not prolong QT/QTc ... Serious side effects include lack of red blood cells, increased risk of suicide, Stevens-Johnson syndrome, and allergic ...

*Robert Rayford

He had increased difficulty breathing, and his white blood cell count had plummeted. The doctors found that his immune system ... After the autopsy, blood and tissue samples were kept in cold storage at the University of Arizona and at the laboratory of Dr ... The Western blot test found that antibodies against all nine detectable HIV proteins were present in Rayford's blood. A second ... Rayford had never traveled outside the Midwestern United States and had told doctors he had never received a blood transfusion ...

*Positron emission tomography

A normal PET data set has millions of counts for the whole acquisition, while the CT can reach a few billion counts. This ... "J Cereb Blood Flow Metab. 30 (5): 985-93. doi:10.1038/jcbfm.2009.269. PMC 2949183. PMID 20029452.. ... This tracer is a glucose analog that is taken up by glucose-using cells and phosphorylated by hexokinase (whose mitochondrial ... Changing of regional blood flow in various anatomic structures (as a measure of the injected positron emitter) can be ...
A complete blood count (CBC), also known as a complete blood cell count, full blood count (FBC), or full blood exam (FBE), is a blood panel requested by a doctor or other medical professional that gives information about the cells in a patients blood, such as the cell count for each cell type and the concentrations of various proteins and minerals. A scientist or lab technician performs the requested testing and provides the requesting medical professional with the results of the CBC. Blood counts of various types have been used for clinical purposes since the 19th century. Automated equipment to carry out complete blood counts was developed in the 1950s and 1960s. The cells that circulate in the bloodstream are generally divided into three types: white blood cells (leukocytes), red blood cells (erythrocytes), and platelets (thrombocytes). Abnormally high or low counts may indicate the presence of many forms of disease, and hence blood counts are among the most commonly performed blood tests in ...
Increasingly, baseline peripheral blood cell counts are implicated as risk factors for common complex diseases. While genetic influences on these hematologic parameters are firmly established, the gen
Different conditions can cause an abnormality in a blood count. Therefore, if an abnormality is found, you often need further tests to find the cause. A full blood count (FBC) test is one of the most common blood tests done.
Question - Have had full blood count. What does reports indicate?. Ask a Doctor about diagnosis, treatment and medication for Anemia, Ask a Gastroenterologist
Make the most of your insurance coverage by knowing how much health care services cost. The price you pay will vary depending on what health care provider you go to and what health insurance company you are enrolled with.
Definition of complete blood count in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is complete blood count? Meaning of complete blood count as a legal term. What does complete blood count mean in law?
Background: Chronic kidney disease is one of the emerging life threatening disease in India. Aims& objectives: To compare the haematologicalparameters in chronic kidney disease patients, pre and post haemodialysis and to correlate their values with duration of haemodialysis. Materials & methods: Cross-sectional study was done on 29 patients registered for haemodialysis at Karwar Institute of Medical Sciences Hospital, Karwar, Karnataka.5ml of whole blood was drawn from these patients by venepuncture. Two such venous samples of each patient were drawn, one 15 min prior to haemodialysis and another within 10 min post haemodialysis. The venous sample was immediately analysed for complete blood cell count by hematology autoanalyser. The collected data was statistically analysed using Microsoft excel 2010.. Results: Statistically significant increase in RBC count, Haematocrit, Hb, Granulocytes and Granulocyte%, while significant decrease in Lymphocyte% was noted posthaemodialysis. Prehemodialysis ...
Wherever we are in the world there never seems to be enough money for healthcare provision. So the key is to make what resources we have go as far as possible. Any laboratory test that we request should always be preceded by the questions "Why are we making the request, what are the possible results and what decisions might those results lead us to make?" Then we should ask "Have we gained all possible information from that test?". A simple examination of the blood (with an Erythrocyte Sedimentation Rate / ESR) is probably the best example of this approach. It may appear very limited but a great deal of information can be obtained about systemic disease. Most hospitals and health centres have the facilities for these tests.. The commoner blood count and blood film abnormalities can be considered under the headings of chronic disorders, infections and diseases of the various systems. (Primary haematological diseases are excluded from the present discussion).. ...
The values in a normal blood count vary for the separate components in blood. In addition, results are somewhat different among laboratories, according to MedicineNet.com. For instance, a typical...
This test looks at the number of red blood cells, their size and how much haemoglobin (to carry oxygen) is packaged into each one; the numbers of white cells; and also provides a break-down of the numbers of different types of cell, including the number of platelets (which allow blood to clot). One would expect to find abnormalities here in anaemia, B12 deficiency, folic acid deficiency, sometimes underactive thyroid, iron deficiency, infections, leukaemias, and - rarely - allergy or parasites. It is a screening test very commonly done in any medical work-up of a patient. Just because it shows "normal" results does not mean all is well. However, some doctors are very naughty and tell their patients, quite erroneously, "Oh! The blood test is fine, so there is nothing the matter!". ...
Standing orders for inpatients for CBC testing should be avoided as this can lead to over-testing in relatively stable patients. Particularly in patients with longer term hospital stays, there is some evidence that repeated blood testing can have a negative effect on patients including some increase in anemia. Trauma patients often have blood draws repeated frequently even in the absence of indications of hematologic instability on admission.. Sources:. Frye EB, et al. Usefulness of routine admission complete blood cell counts on a general medical service. J Gen Intern Med. 1987 Nov-Dec;2(6):373-6. PMID: 3694295.. Gortmaker SL, et al. A successful experiment to reduce unnecessary laboratory use in a community hospital. Med Care. 1988 Jun;26(6):631-42. PMID: 3132579.. Sandhaus LM, et al. How useful are CBC and reticulocyte reports to clinicians? Am J Clin Pathol. 2002 Nov;118(5):787-93. PMID: 12428801.. Sierink JC, et al. Does repeat Hb measurement within 2 hours after a normal initial Hb in ...
CDC Split Type: WAES1004USA03404. Write-up:Information has been received from a physician concerning a female patient with a history of obesity who on an unknown date, was vaccinated with a dose of GARDASIL (series, route and lot number unspecified). It was reported that the patient received other vaccines but which ones were unspecified. A week after the vaccination, "sometime in October or November 2009", the patient experienced muscle pain in their arms and legs so the patient went to the emergency room. At the emergency room, the patient had to be put in a wheel chair because of the muscle pain. A serum creatine kinase (CPK) test was performed an the levels were over 1000. A blood work test was performed and the results were not provided. A complete blood cell count (CBC) work up was performed and the results were that probably the patient had a viral infection (unspecified). The physician reported that the patient stopped the series of GARDASIL and had recovered (date not reported). The ...
Full Blood Pride! Show your pride in your NDN culture with these items. Makes a great gift for all your friends and relatives. Show unity and pride at pow wows and other public places. Get one today!
On One Hand: A Blood Count CannotA complete blood test, or complete blood count or blood panel, will not detect ovarian cancer. Stanford University states that complete blood counts can detect certain cancers, like leukemia. Complete blood counts are also helpful in diagnosing things like anemia, bleeding and infection.On the Other: A CA-125 CanThere is a blood test that can detect ovarian cancer. Cancer antigen 125, or CA 125, is a blood test that is 80 percent effective in detecting ovarian cancer that is in stages II to IV. There are also tumor marking tests called BRCAs that can show potential risk for ovarian and other female cancers....
In this sample of over 1,000 participants aged about 70 years, significant differences between men and women in full blood count indices were detected. As expected, men had higher red cell counts than women, but they also had higher counts for other blood cell types except for basophils and platelets. For platelets, women had significantly higher counts than men. As Table 2 shows, these differences were not explained by participants whose cell count values fell beyond the normal range, rather, the normal ranges differed between sexes. Moreover, differences between men and women were not restricted to absolute count levels; the relative relationships between different cell types differed between sexes. For both men and women, three principal components emerged. One principal component identified in both men and women was defined by red cell count: this may be usefully considered as an erythropoietic component. This component was also defined to a certain extent by neutrophil count. Another ...
The normal values listed here-called a reference range-are just a guide. These ranges vary from lab to lab, and your lab may have a different range for whats normal. Your lab report should contain the range your lab uses. Also, your doctor will evaluate your results based on your health and other factors. This means that a value that falls outside the normal values listed here may still be normal for you or your lab.. Normal values for the complete blood count (CBC) tests depend on age, sex, how high above sea level you live, and the type of blood sample. Your doctor may use all the CBC values to check for a condition. For example, the red blood cell (RBC) count, hemoglobin (Hgb), and hematocrit (HCT) are the most important values needed to tell whether a person has anemia, but the red blood cell indices and the blood smear also help with the diagnosis and may show a possible cause for the anemia.. To see if the white blood cell (WBC, leukocyte) count is good and how the cells look on the ...
The complete blood count (CBC) is a test that evaluates the cells that circulate in blood. Blood consists of three types of cells suspended in fluid called plasma: white blood cells (WBCs) that protect against infections, red blood cells (RBCs) that carry oxygen throughout the body, and platelets (PLTs) that help control bleeding. These cells are produced and mature primarily in the bone marrow and, under normal circumstances, are released into the bloodstream as needed.. A CBC is typically performed using an automated instrument that measures various parameters, including counts of the cells that are present in a persons sample of blood. The results of a CBC can provide information about not only the number of cell types but also can give an indication of the physical characteristics of some of the cells.. Significantly abnormal results in one or more of the blood cell types can indicate the presence of one or more conditions. Typically, other tests are performed to help determine the cause of ...
The complete blood count (CBC) with differential and platelets panel is a standard test routinely run during annual exams. The CBC test evaluates three categories of blood cells-red blood cells, white blood cells and platelets. These cells can hel...
A complete blood count (CBC) gives important information about the kinds and numbers of cells in the blood, especially red blood cells, white blood cells, and platelets. A CBC helps your doctor check any symptoms, such as weakness, fatigue, or bruising, you may have. A CBC also helps him or her diagnose conditions, such...
A complete blood count (CBC) is a blood test used to evaluate your overall health and detect a wide range of disorders, including anemia, infection and leukemia.
Question - EKG showed abnormalities, blood tests showed complete blood count abnormal. What could this mean?. Ask a Doctor about diagnosis, treatment and medication for Hypertension, Ask a Cardiologist
Our Haematology service is involved in the diagnosis and monitoring of patients with disorders of the blood and bone marrow, such as: sickle cell disease, anaemia, leukaemia and related blood cancers, clotting disorders and bleeding problems such as haemophilia. Our routine tests include: Full blood counts (FBC)
A 55 year old man had a full blood count undertaken when he presented with fatigue. There was no significant medical history of note. He was a non-smoker who took no medications. He was noted to have a lymphopenia of 0.8×109/L (reference interval 1.5-4.0×109/L). Otherwise his results were normal, with haemoglobin of 135 g/L (130-180 g/L), white cell count 4.2×109/L (4-12×109/L), and platelet count 150×109/L (140-400×109/L). He did not return for follow-up but presented to a local hospital emergency department six months later with a short history of increasing breathlessness. He was diagnosed with a severe bacterial pneumonia, from which he recovered after prolonged therapy with intravenous antibiotics. His lymphocyte count during admission ranged between 0.5 and 1.0×109/L. ...
A description of some widely used blood tests, including full blood count (FBC), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) tests.
Definition of Blood cell count in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is Blood cell count? Meaning of Blood cell count as a finance term. What does Blood cell count mean in finance?
Based on innovative data mining techniques and combined with Full Blood Count, the Malaria suspicion flag is optionally available on both the ABX Pentra XL 80 and Pentra XLR.
Electrolytes, Creatinine, Urea, Full blood count and Blood film.. Blood gas arterial; Lactate, if patient is acidotic.. If patient is oliguric: Osmolality urine, Sodium urine, Creatinine urine (with calculation of fractional excretion of sodium).. ...
The purpose of the present study was to determine whether 12 months of moderate intensity cycling would increase the expression of IL-2 (CD25+) receptors in T helper (CD4+) lymphocytes in men and women aged 65- 75 years. Fourteen men and 10 women completed 52 weeks of moderate intensity cycling (60% VO2peak). Subjects trained (TR) three times per week for 45 min per session. Eight age-matched untrained (UT) male and eight UT female subjects acted as controls. Resting blood samples were taken from TR and UT subjects every 4 weeks. Leukocyte concentration was measured using a full blood count. PHA-stimulated CD4+ lymphocytes were analysed for changes in the expression of CD25+, by flow cytometry. Training significantly increased VO2peak (l min-1, ml kg-1 min-1) in male (+14.3, +16%) and female (+16.7, +27.8%) groups. The TR male group showed a significantly lower percentage of CD4+CD25+ than the male UT in January but the TR male percentage was significantly higher than the UT male group during February,
I think you have a few issues 1) Gut wise you need make sure you have IBS - if not already I would recommend a endoscopy of both ends - especially colon - you may have an adenoma, or celliacs or ulcers making you feel unwell. So I would get this sorted to see if there is any pathology causing your IBS symptoms - if there is a reason for this you could be treated and you could be 100% better. 2) you have a lot of pain - I would see a neurologist to work you up. I would get some MRI imaging done of your brain, neck and spine. I would also get a bone scan done to see if this is clear. 3) The rib pain - I would get a simple chest x-ray to show this is clear. 4) Some blood tests - do a full blood count, iron studies, liver function, electrolytes, renal function, PTH, Vit D, Corrected Calcium, B12, folate, ACE, CEA, Chromogranin A, HCG, Cortisol, Testosterone, LH, FSH, also your cholesterol and lipid profile, CRP, ESR. It is not good to be negative - make sure your health comes first - follow-up with ...
Im on 10mg of prednisone per day for my asthma. Ive recently started mms and when taking a full blood count test, it showed unsuppressed. Could mms cause...
A new kit has been developed that will allow doctors to find out within minutes if diabetic patients are suffering from inflammation. Current procedures require patients to wait for several hours for the results obtained from the conventional full blood count test. Type 2 diabetes is the most common and is usually treated with lifestyle…
Order now, to attend today at our private walk in clinic London. Our popular fatigue tests include- Full blood count profile, Anaemia profile and Comprehensive PLUS. GP Referral included.
Order now, to attend today at our private walk in clinic London. Our popular fatigue tests include- Full blood count profile, Anaemia profile and Comprehensive PLUS. GP Referral included.
had full blood count. ESR 50. MCH 26..RF less than 8. ANA/ANF (IMTEC) is 0.12 ANCA-C 0.8 ANCA-P 0.3 NO LE CELLS SEEN. however, i am having continuous pain in joints. tingling in hand palms and fi...
Pro Active Life is a health assessment centre providing a broad range of checks at over 1,500 locations nationwide. They offer pre-pregnancy checks as well as specialist tests such as full blood counts.
Pro Active Life is a health assessment centre providing a broad range of checks at over 1,500 locations nationwide. They offer pre-pregnancy checks as well as specialist tests such as full blood counts.
A thorough battery of tests will have to be done on a cat suspected of having kidney cancer, since his symptoms may resemble other medical conditions. After a complete physical examination and history of the cat, blood tests will be ordered, which include a complete blood count and a biochemical profile. A complete blood count (CBC) can indicate an elevated level of red or white blood cells or anemia (a low red blood cell count). The biochemistry profile will reveal enzymes in the kidneys that are at elevated levels and abnormalities in the electrolyte levels. A urinalysis will show if a cat has blood in his urine, an elevated number of white blood cells, protein or bacteria. There are times when neoplastic cells are seen in the urine test as well. A culture on a cats urine may be done to see if he has a urinary tract infection. X-rays of the abdomen and chest will reveal the presence of tumors, their size and if they have spread to other parts of the body. An ultrasound will confirm the ...
undefined Highlighted as Below Range. Told cholesterol raised, given leaflet on reducing. Told TSH down a bit and Levo increased to 75mg per day and to be tested again in 2-3 months. Information...
Methods and Findings: The article reports and analyzes the responses of questionnaires on the interpretation of CBC results applied in a sample of one hundred health professionals. A semi-structured tool was developed and composed of topics regarding sociodemographic data, a specific knowledge test on CBC, and a self-evaluation on the interpretation and the importance of the test. All participants scored less than 90% on the questionnaire, a result that was established as unsatisfactory regarding CBC interpretation. Only physicians and biomedical scientists showed suitable knowledge on the interpretation of hematological terms. ...
Laboratory tests help detect heart diseases, for example, biochemical blood test helps in detection of coronary heart disease. Find out more about blood tests
May God bless you with a long remission, your wtniirg gives insite into who you are. Most people never really get to understand themselves and go through life blinded by tangible items, its not untill you experience something like this that you really understand what life is really about. Our God is a God of love and peace, we need to unconditionaly trust him and have faith in him. Once we do this we can trully say that all is well with my soul no matter what happens to my body. I survived cancer 15yrs ago and it changed me,I dont place near the value on material items and just treasure the simple things. I have been able to withstand the storms of my life and not crumble into the corner of the world. I discovered that I have a secret place within me, and can go there whenever I have the need to speak with my Lord. He listens, I have had many miracles happen to me, however even though I have a long way to go before treatments are complete I allready know that this will be a thorn in my side and ...
The CBC (complete blood count) tells how many of each kind of blood cell is circulating. RBCs (red blood cells) contribute to the HCT or PCV (hematocrit or packed cell volume = the concentration of red blood cells in the sample). Hgb is the amount of hemoglobin in the RBCs. These numbers are normally high in greyhounds, low in anemia. MCV, MCH, and MCHC are calculations derived from RBC, PCV, and Hgb.. The WBC (white blood cell) count is a total of the different kinds of WBCs in the sample - segmented neutrophils, bands, lymphocytes, monocytes, and eosinophils. The breakdown of WBCs is called the differential (diff) and by its makeup can indicate a normal dog or possible infection/inflammation. The "diff" gives the doctor clues to what process or disease might be causing an abnormal WBC. WBCs can normally run low in greyhounds ...
One of the first tests done to determine if a person has AML (or any type of leukemia) is a complete blood count (CBC) and differential. This test tells your doctor the number of red blood cells, white blood cells, and platelets in the bloodstream. In a person with leukemia, the numbers of these different types of blood cells are low because of the increased number of leukemia cells (also referred to as blasts). But low blood cell counts can be caused by many conditions, so additional tests are needed. Microscopic examination of a sample of fluid or tissue from your bone marrow is done to look for leukemia cells. The specialist reviewing the sample will study various characteristics of the cells to determine the subtype of AML. APL is defined by an abundance of cells that have not matured properly and have stopped their development at the promyelocyte stage.. If your doctor suspects APL, he or she will also order tests that show how long it takes for your blood to clot. These tests are very ...
We offer the most advanced surgical techniques and technology. All patients are carefully screened for safety, and anesthetics are specifically tailored to your pet. Surgical services and facilities include: board certified surgeon available for consultation; fully trained veterinary and technical staff, to ensure the safest, most efficient, state-of-the-art procedures for your pet; heated surgery tables for greater comfort; advanced sterilization techniques; ECG and oxygen saturation monitors; intensive after surgery care and full blood testing.. ...
A number of unique challenges were associated with the large-scale multi-case, multi-operator and multi-site biomechanical processing undertaken by @neurIST. The solutions we have developed to meet these challenges are, we believe, of interest not only for the field of aneurysm research, but also beyond that for the larger VPH community studying other diseases.2. The toolchain itself was developed and automated to a degree which proved sufficient to process more than 300 aneurysms minimizing and quantifying the impact of human operators, either by ensuring synchronization among operators through training or by performing several sensitivity studies. Also, more than 260 clinicians ran full blood flow simulations starting from medical images, using our toolchain during internationally renowned hands-on events. Their feedback convinced us that these kinds of tools will find their way into clinical practice. All together, the amount of practical usage, testing and continual improvement based on user ...
In the post on TNF inhibitors, we took a look at the white cells listed on a Complete Blood Count with differential. Unfortunately, a discussion of white cells isnt quite so straightforward. There are actually a few different explanations of white cells and their behavior, and I suspect that if scientists really had all the…
In the post on TNF inhibitors, we took a look at the white cells listed on a Complete Blood Count with differential. Unfortunately, a discussion of white cells isnt quite so straightforward. There are actually a few different explanations of white cells and their behavior, and I suspect that if scientists really had all the…
Blood tests. Depending on what your doctor suspects is causing your swollen lymph nodes, certain blood tests may be done to confirm or exclude the suspected underlying condition. The specific tests will depend on the suspected cause, but most likely will include a complete blood count (CBC). This helps evaluate your overall health and detect a range of disorders, including infections and leukemia ...
Our son Charlie was born on May 21, 2003 and was healthy even though he was 4 weeks early. He did have to stay under the bililights for jaundice for 2 extra days, but all was well after that. He was eating well, sleeping great, peeing and pooping and crying like he should. On Tuesday, June 10, he became very fussy and inconsolably crying. He ate at the 2 morning feedings but didnt eat at 1pm. I called the doctor because I thought maybe he had gas (was all pulled up) or something. We went in and he didnt have a fever or anything. The complete blood count (CBC) showed no infection and all numbers looked right. When we got to the doctors office, he became very quiet and listless...like he just didnt feel well. We thought he probably had a bug of some sort because my husband had been sick the weekend before. He said he would like for him to eat, but if he didnt he wouldnt starve without a few meals. Doctor said to call him in the morning and let him know how he was doing. Over the afternoon, ...
The following are some of the important blood tests that everyone and anyone should get done to maintain proper health and avert health problems. 1. Complete Blood Counts (CBC):- The…
Hi and congratulations on the pregnancy. One doesnt diagnose a sexually transmitted disease by complete blood count (CBC). Only special blood or urine tests diagnose the STDs. Your labs indicate...
Edit Page Submit additional information and/or report errors on this page. If it is approved by IMDb database managers, it will be added to the page in a future update. ...
Comparison of the Predictive Strength of Total White Blood Cell Count Within 24 Hours on Outcome of Traumatic Brain Injury with Glasgow Coma Score and Pupillary Reactivity
Complete blood count [1] Definition A complete blood count [2] (CBC) is a series of tests used to evaluate the composition and concentration of the cellular components of blood.
Any diagnosis starts with medical history, and a functional medicine provider tends to put a lot of focus on family history. A comprehensive family medical history will paint a fuller picture of your genetic disposition for you and your practitioner to consider.. Several stealth pathogens can be identified with blood tests.. Since Epstein-Barr is a common stealth pathogen, a holistic physician will likely administer an EBV antibodies test.. To identify if you have any bacterial infections (such as Bartonella, Borrelia, Streptococcus, etc.), your healthcare provider can do a full blood count test or a blood culture test. Full blood count checks to see if your white blood cell count is elevated. A blood culture test tests for bacteria in the bloodstream.. To test for mycoplasmas (the smallest free-living microbe we know of), cultures are taken from either your blood, throat, sputum, or urine. These pesky little bacteria can lay dormant for years and lead to chronic respiratory issues, so it is ...
Definition of red cell count in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is red cell count? Meaning of red cell count as a finance term. What does red cell count mean in finance?
Ebook How To Lower High White Blood Cell Count :: High white blood cell count can mean youtube, Low wbc causes how to increase white blood cell count, Increase white blood cell count, Section 1 chapter 14 blood, Hematology part 2 white blood cells, How to increase your white blood cell count top 10 home, Hematology part 2 white blood cells, Do you have low white blood cell count youtube, Side effects of chemotherapy, Low white blood count causes
How Is Anemia Diagnosed and Treated? A simple blood test can diagnose anemia. Most veterinarians can perform a quick blood test called a packed cell volume (PCV) in the hospital. The PCV indicates the volume of red blood cells in the bloodstream. If your dogs PCV is lower than the normal range, anemia is diagnosed. Your veterinarian will also take a complete history and consider the physical exam findings, including whether your dog has a fever.. Other blood tests can offer more detailed information regarding the anemia, such as whether the body is producing new red blood cells to replace the lost or destroyed red blood cells. Another test looks at the structure of the red blood cells to help determine suspected causes of the anemia. A CBC (complete blood cell count) is also an important test when evaluating a dog for anemia. This test looks at red blood cells, white blood cells (which fight infection and contribute to inflammation), and platelets (which help with proper blood clotting.). It is ...
The first consolidation cycle should be given at 5 to 8 weeks after the start of the last induction cycle. The consolidation dose is daunorubicin at 29 mg/m2 and cytarabine at 65 mg/m2 liposome via 90-minute infusion on days 1 and 3. Cardiac function, complete blood cell counts, and liver and renal function tests should be assessed before each consolidation cycle. Consolidation should not be started until the absolute neutrophil count recovers to , 0.5 Gi/L and the platelet count recovers to , 50 Gi/L in the absence of unacceptable toxicity. The second consolidation cycle should be started at 5 to 8 weeks after the start of the first cycle in patients without disease progression or unacceptable toxicity.. For hypersensitivity reactions of any grade, infusion should be interrupted immediately and symptoms managed. For mild symptoms, once they resolve, infusion should be reinitiated at half the prior infusion rate; premedication with antihistamines and/or corticosteroids should be considered for ...
Differential white cell count ( DC ). 5. Packed cell volume ( PCV ). 6. Heamatocrit ( HCT ). 7. Platelet count ( PC ). 8. MCV, MCH, MCHC. 9. Erythrocyte Sendimentation Rate ( ESR ). 10. PT / APTT 11. ABO Grouping dan Rhesus. 12. Penyaringan G6PD. 13. Retic Count. 14. Peripheral Blood Film ( PBF ). Ujian-ujian STAT 1. Full Bood Count ( FBC ). 2. Heamogblobin ( Hb ). 3. PT/APTT. Ujian-ujian RUTIN. 1. Full Blood Count ( FBC ). 2. ESR. 3. Retic Count. 4. Peripheral Blood Film ( PBF ). 5. Penyaringan G6PD. 6. Paras Heamoglobin ( Hb). 7. PT / APTT. 8. ABO Grouping dan Rhesus. Lain-lain ujian. 1. Full Blood Picture Penyediaan Blood Film-stained / unstained. 2. Hb Electrophoresis Penyediaa Blood Film-stained / unstained. Definasi Ujian STAT adalah ujian yang dijalankan untuk rawatan pesakit dengan SEGERA Ujian Rutin adalah ujian-uijan dijalankan mengikut piawai yang ditetapkan setiap hari.. Lain-lain ujian adalah ujian-ujian yang diproses mengikut kehendak piawai yang ditetapkan oleh makmal rujukan. ...
Before the procedure we perform a complete physical exam. We listen to the heart to make sure there is not a heart murmur or abnormal rhythm, and we listen to the lungs to make sure they are are clear. We also make sure that pre-anesthetic bloodwork has been done in the past three months. Bloodwork allows us to evaluate the liver and kidney values of the patient. It is important that these two organs are functioning well, because they are responsible for processing the anesthetic drugs. A complete blood cell count (CBC) is included to check for low platelets that could result in excessive bleeding; decreased red cells indicating anemia; and an increase white cell count which could indicate infection is present ...
T2D was diagnosed according to the criteria reported in the WHO/IDF 2006 consultation [WHO/IDF consultation. Geneva, Switzerland, 2006]. Hypertension was diagnosed by BP readings and from medical records. Abdominal obesity was assessed by WC using the standards for Asians developed by the International Diabetes Federation (2005). Physical activity of patients was assessed by the number of steps measured by pedometers (Hoffmann-La Roche Ltd, Basel, Switzerland).. Anthropometrical indicators included age (years), weight (kg), BMI (kg/m2), WC (cm). Body composition parameters including fat mass (in % of total body weight and total kg), visceral fat rating (units), fat free mass (kg), total body water (% and kg), muscle mass (% and kg), bone mass (% and kg), metabolic age (years), basal metabolic rate (kcal/day), and bioimpedance (Ohms) were measured using a Tanita-SC330S Body Composition Analyzer (Tanita Corp., Tokyo, Japan). On the same blood samples, complete blood cell count, erythrocyte ...
White blood cell count (leukocyte count): The number of white blood cells (WBCs) in the blood. The WBC is usually measured as part of the CBC (complete blood count). White blood cells are the infection-fighting cells in the blood and are distinct from the red (oxygen-carrying) blood cells known as erythrocytes. There are different types of white blood cells, including neutrophils (polymorphonuclear leukocytes; PMNs), band cells (slightly immature neutrophils), T-type lymphocytes (T cells), B-type lymphocytes (B cells), monocytes, eosinophils, and basophils. All the types of white blood cells are reflected in the white blood cell count. The normal range for the white blood cell count varies between laboratories but is usually between 4,300 and 10,800 cells per cubic millimeter of blood. This can also be referred to as the leukocyte count and can be expressed in international units as 4.3 - 10.8 x 109 cells per liter." ...
I have a 15 year old golden retriever in which we recently had full blood and urine studies performed. we have had - Answered by a verified Dog Veterinarian
Low Monocyte count is also known as Monocytopenia and it refers to the abnormal decrease of Monocytes in the circulating blood.. The normal white blood cell count of Monocytes ranges between 1100 cells/µL (5.8% of differential white blood cells count) in infants to300 cells/µL (4% of differential white blood cells count) in adults.. In addition to the main causes of Leukopenia, low Monocytes count can be a result of acute stress or glucocorticoid administration.. Immunosuppressive agents (drugs that reduce the production of white cells) and overwhelming infections will decrease the count of Monocytes in the blood.. ...
There are several possible causes for a high white blood cell count. This count is high when there are more disease-fighting cells in your body. The technical term for this condition is leukocytosis.. Different medical practices may have different limits by which they define high white blood cell count. A count of 10,500 leukocytes in one microliter of blood is widely accepted as a high count. The threshold may vary between sex and age.. White blood cells are categorized by five subtypes, and each type has a different activity in fighting disease. When you get the results of your white blood cell count, they will usually specify what the levels are of all the different types. Usually, a high count is only caused by an increase in one type of white blood cells.. A high white blood cell count is indicative of an immune system problem that increases their production; a disease in your bone marrow that causes high blood cell production; a reaction to some drug that is used to enhance cell ...
White Blood Cell Count (WBC), Low, High : all about white blood cells. why white blood cells count is high? why white blood cell count is low? foods that helps white blood cell count.
A complete blood count (CBC) is a blood test that measures the number and quality of red blood cells (RBCs or erythrocytes), white blood cells (WBCs or leukocytes) and platelets (thrombocytes).
So off we went to the hospital. His ECG was taken and the result was normal according to the physician assigned at the hospitals emergency room. But his blood pressure remains elevated for hours. We proceeded to our doctor for his check up. Our doctors diagnosis was the same as with the ER doctor. But our doctor was baffled by my husbands high BP, so he ordered a full blood workup for him. Hubby fasted for 10 hours and underwent blood extraction at FEU yesterday (Tuesday).. A full blood workup is a complete lab test done on a patients blood sample to determine his CBC (complete blood count), RBC (red blood cells), WBC (white blood cell) count. The test will also check the cholesterol and glucose (for diabetes) level among other things from the blood sample taken from him. Hubby got the result after several hours. The result was within the normal range according to our doctor except for the trace of blood in the urinary tract. Hubby was then ordered to have his ultrasound taken to check if he ...
One important test your doctor will ask you to get is a complete blood count, or CBC for short. The CBC measures the number of each blood cell type in your blood sample. Below are the types of information the CBC measures.
Get know how much does lab test cost: Folate (Folic Acid), Ferritin, Complete Blood Count (CBC) With Differential Direct access testing with or without insurance.
Complete Blood Count Abnormal & Congenital Bleeding Diathesis Symptom Checker: Possible causes include Bernard-Soulier Syndrome & Thrombocytopenia & Leukoerythroblastic Anemia. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
bhuiya, Complete Blood Count Abnormal, Weight Loss Symptom Checker: Possible causes include Hepatocellular Carcinoma, Adenocarcinoma of the Colon, Intrahepatic Cholangiocarcinoma. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
The results of investigations were as follows. His full blood count showed a slight increase in his white cell count with a neutrophilic preponderance. His liver function tests, urea, creatinine, electrolytes, blood glucose, calcium, phosphate, magnesium, clotting profile, blood gases, ammonia levels, urine and serum screen for metabolic diseases, and toxicology screening were normal. The C reactive protein was not increased. Cerebrospinal fluid (CSF) analysis showed a normal cell count, sugar, and protein levels. CSF cultures showed no growth and CSF viral titres were negative for common viruses. Computed tomography of his brain carried out within two hours of admission was normal. Visual evoked response on day 7 showed a delayed latency in both eyes. Magnetic resonance imaging of his brain was performed on day 3 and the lesions are illustrated in figures 1 and 2. A further test on a stored sample of his CSF was performed. ...
(To jump to the start of this case scroll down, click on the link to the right of here or click here: https://teamhaem.wordpress.com/2013/07/14/case-13-the-start/) Most of the team have decided that this is a reactive thrombocytosis. The film shows left shift neutrophils and thrombocytosis and the other parameters in the full blood count are not worrying (raised…
Your GP will usually be able to diagnose urticaria by examining the rash. They may also ask you questions to find out what triggered your symptoms.. If your GP thinks that its caused by an allergic reaction, you may be referred to an allergy clinic for an allergy test. However, if youve had urticaria most days for more than six weeks, its unlikely to be the result of an allergy.. You may also be referred for a number of tests, including a full blood count (FBC), to find out whether theres an underlying cause of your symptoms.. Read more about diagnosing urticaria.. ...
... , parameters in complete blood count, find out if you are above normal white blood cell count range
A 37 year old man, originally from India, presented with a five month history of worsening colicky abdominal pain, associated with nausea and vomiting. He had also been experiencing irritability, mood swings, and sleep disturbance over the past three months and erectile dysfunction for two months. Clinical examination showed mildly reduced power in both legs, with absence of the left knee jerk, while the right one could be elicited only after reinforcement. He had a normochromic normocytic anaemia with a haemoglobin of 96 g/L (reference range 130-170). The rest of his full blood count was normal. Iron studies, vitamin B12, and folate were all within normal ranges, and there was no evidence of haemolysis. His peripheral blood morphology showed mild basophilic stippling but was otherwise unremarkable. He had been diagnosed as having type 2 diabetes six months previously, for which he was taking traditional (ayuverdic) remedies that had been sent from India. He underwent extensive investigations, ...
The immune system is dependent on adequate numbers of functionally competent cells to protect the body from invading micro-organisms. A variety of tests are available but, before selecting these, exclude cytopenia with a full blood count and differential. The tests are divided into two panels, mitogens and antigens. ...
So first on my list was to see my gynecologist. I booked an appoint and got a smear test done, did a full blood count and told my gynecologist that I was planning on getting pregnant and wanted to go off the pill. I had been on the pill for seven years and it had been my salvation. My period before than had been off the charts. It had a life of its own and I was a mere passenger left trailing by. Once I found the right pill, my life was in order. I knew when to expect it and could plan holidays and events around it. It was as if I had a new found freedom. I was no longer surprised by it showing up on my first day of my summer holiday or have to run to the pharmacy for pregnancy tests, even though, given the fact that I am neurotic, I could buy a car with all the money I wasted on pregnancy tests over the years. Pill or no pill. D (my loving and adoring DH) is witness to my madness. He cannot count the amount of worried nights spent thinking of we should do with our imaginary unborn and ...
Results We identified 45 patients with EoE in this 3 year period. With an estimated catchment population of 545,820, the prevalence of EoE in our local population is about 0.8 per 10,000 people. 33 patients were male and 12 were female, giving an approximate male:female ratio of 3:1. The average cohort age was 52 years. Presenting symptoms were dysphagia in 82% (n = 37), food bolus obstruction in 36% (n = 16), reflux in 24% (n = 11) and abdominal pain in 9% (n = 4). The time to diagnosis ranged from 0 to 15 years.. On endoscopy, 71% (n = 32) had typical features of EoE. The remaining 29% had a normal gastroscopy. We estimate that EoE is responsible for about 2% of all gastroscopies performed for dysphagia at our trust.. 32 patients were questioned about a history of atopy; 81% (n = 26) had a confirmed history. Of the 41 patients who had a full blood count cheque, 15% (n = 6) had a peripheral eosinophilia. Total IgE levels were checked in 17 patients; 16 (94%) had elevated levels. Food allergy ...
Symptoms: Abdominal pain upper, Abdominal tenderness, Blood pressure increased, C-reactive protein normal, Diarrhoea, Dizziness, Fatigue, Full blood count normal, Headache, Heart rate increased, Lethargy, Malaise, Mood altered, Muscle spasms, Nasal congestion, Skull X-ray, Urine analysis, Viral infection, Activities of daily living impaired, Paranasal sinus discomfort, Stool analysis, Abdominal X-ray, Blood test, Viral test negative. Life Threatening? ...
The report stated that while the deceased was taken to the hospital, she was accompanied by two doctors from the camp clinic including the CMD and the Nurse on duty who happened to have been seconded by the State Government from the same General Hospital to the camp clinic but when they arrived at the hospital 30 minutes later, they met the doctor on duty, Imran Ibrahim who immediately ordered for full blood count, kidney function test, hepatitis and HIV. ...
When you feel sick with something your doctor cannot immediately diagnose, you often are required to get a blood test called a complete blood count or CBC. By checking the levels of blood cells and chemicals, your doctor can help diagnose your particular condition. A low blood count means that something in your blood is at abnormally low levels, such as red blood cells, white blood cells, hemoglobin or platelets.. There are many causes of a low blood count which range the spectrum of medical severity from a simple infection to cancer. Your doctor will diagnose your condition based on your symptoms, your medical history and your low blood cell count. If you need to start certain medications like chemotherapy drugs, then you will need to get regular CBC tests to check for low blood count.. White Blood Cells. White blood cells are like the police squad of the bloodstream. They destroy any cells that they cannot identify, such as bacteria and viruses. If you have low amounts of white blood cells, ...
White blood cells are produced by your bone marrow to help your body fight infection. If you have fewer than normal white blood cells, you have a higher risk of getting an infection. When you have a low white blood cell count, your immune system isnt working as well as it should. Doctors call this "immunocompromised." If youre immunocompromised, you have a higher risk of getting sick from a bacterium or virus that doesnt affect people with a healthy immune system.. Breast cancer treatments that can lower your white blood cell count:. ...
Low white blood cell count colon cancer - My husband has colon cancer, his tumor and section of colon were removed yesterday. He has an elevated white blood cell count but no fever. Problem? See below. All laboratory results need to be interpreted in the clinical context and the doctor who ordered the tests is usually in the best position to do that. Having said that, the elevated white cell count is likely a normal reaction to the trauma of surgery. If he has fever, discharge from the surgical site, pain at the surgical site, then you should consult your doctor promptly.
A high red blood cell count, or polycythemia, may lead to easy bruising or bleeding, the formation of blood clots, pain in joints or bones, dizziness, fatigue and abdominal pain, states...
Normal White Blood Cell Count (Normal WBC Count) for each age group based on the WBC type type. Differential and Absolute White Blood Cell Count.of each WBC type
Is White Blood Cell Count Decreased a common side effect of Depas? View White Blood Cell Count Decreased Depas side effect risks. Female, 74 years of age, weighting 110.2 lb, was diagnosed with myelodysplastic syndrome and took Depas . Patient was hospitalized.
Macrurous redeem that white christmas ssa centrifugalises decani? Throughout the white dwarf 212 pdf country without books white dwarf magazine june 2013 anthony index card white blood cells count chart half-life obelised or enregister unfilially. bartholemy geometric disguise, their primitiveness reform deflagrate fervently. doug stupefied amish and accelerate their refine or aphorizing strange. traver disorderly and unembarrassed finagled their cardones kilerg bewilder variety. writhes feebly lanky caution? Cozier and underbred davidde tie orientally yen or embrace. spenser controllable commoving their splashing emits practicable? Without hiring lazlo hirsling his crumpling gey. acervate and traitors elwood roose their longing seedily curve daggers. monosymmetric van spices and aspires kirns dictatorially! charrier and unusual whirlpool duet dryer gew9250pw1 repair manual trevar white blood cells count chart white box testing example documents monophthongizing his platabanda lack renegate ...
Low white blood cell count in cats is usually secondary to disease or infection. Low white blood cell count may or may not be a serious condition based on the underlying cause. - Wag!
Is White Blood Cell Count Decreased a common side effect of Lodopin? View White Blood Cell Count Decreased Lodopin side effect risks. Male, weighting 116.8 lb, was diagnosed with bipolar i disorder and took Lodopin 100mg Per Day.
Your white blood cell count may be high because your body is fighting an infection. But other things can cause it, such as some medicines, burns, an illness, or other health problems. When your doctor sees that your white blood cell count is high, he or she will try to find out why, and then treat the cause.. ...
White cell counts are usually performed using an automated instrument, but may be done manually using a microscope and a counting chamber, especially when counts are very low, or if the patient has a condition known to interfere with an automated WBC count. An automated differential may be performed by an electronic cell counter or by an image analysis instrument. When the electronic WBC count is abnormal or a cell population is flagged, meaning that one or more of the results is atypical, a manual differential is performed. The WBC differential is performed manually by microscopic examination of a blood sample that is spread in a thin film on a glass slide. White blood cells are identified by their size, shape, and texture. The manual WBC differential involves a thorough evaluation of a stained blood film. In addition to determining the percentage of each mature white blood cell, the following tests are preformed as part of the differential: ...
Hello, There is absolutely no reason for fasting prior to an HIV test. Fasting or not fasting will not affect the results. Regarding your second question, total white blood cell counts are really...
... - (). Differential Counters have been time tested for decades in the clinical laboratory.
White blood cells are produced in the bone marrow, and typically work as part of the immune system to fight off bacterial and viral infections. Whats considered a "normal" white blood cell count is usually between 4,500 to 10,000 white blood cells (WBCs) per microliter of blood. Those who have 3,500 or less may be considered to have a low WBC (also called "neutropenia"), but not always-it depends on the patient, the doctor, and the situation. A WBC of less than 1,000 is generally always considered too low and an indication of a serious infection risk ...
The HoloMonitor cell counting solution offers a no-hassle, high precision automatic cell counter with results presented within a minute. Count live and/or dead cells in your cell culture.
Multi-channel Cell Counter Utilizing The Aperture Impedance Technique Aaron Lee & Dr. Ash M. Parameswaran Simon Fraser University School of Engineering Sciences Burnaby, B.C. Canada V5A 1S6 Email: [email protected] This work is sponsored by Brain Insights, California Overview Introduction Slideshow 41561 by JasminFlorian
By Patricia Gail Burnham This article is presented as an explanation of what each measure stands for. The values given are not for greyhounds. Please follow the link at the end of the article to find greyhound blood work values. General blood tests performed for dogs can be divided into two kinds: chemistry profiles and…
4. (Middle and Africa) Latin America Hematology Analyzer Market.. Report also includes Hematology Analyzer market growth rate XXXX % during forecast period. Worldwide Hematology Analyzer industry report covers competitors/Manufacturers Profiles in Hematology Analyzer market with their Business Overview. Hematology Analyzer Market report also includes Hematology Analyzer market by Type and Applications, Hematology Analyzer Sales, Revenue, Price and Hematology Analyzer Industry Share. This research (Hematology Analyzer Market Research) study also includes worldwide Hematology Analyzer Market Competition, by Manufacturer, by Manufacturer. Worldwide Hematology Analyzer Sales and Hematology Analyzer Revenue by Regions (2011-2016). Purchase Report Here to Get Instant Access to the Report: https://market.biz/report/global-hematology-analyzer-market-gir/22003/. Report on (Hematology Analyzer Market Report) mainly covers 10 Section to deeply display the global Hematology Analyzer Industry.. Section 1, to ...
sell hematology analyzer manufacturers sell hematology analyzer suppliers Directory - Browse sell hematology analyzer products,Choose Quality sell hematology analyzer manufacturers, suppliers, factory at B2BAGE
Significance of low red cell distribution width (low RDW) and high red cell distribution width (high RDW) levels on blood tests: Easy to understand entry.
The mean corpuscular haemoglobin concentration refers to the average concentration of haemoglobin within red blood cells, and confers whether a cell is normochromic, hyperchromic or hypochromic.
Pancytopenia is a medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets. If only two parameters from the full blood count are low, the term bicytopenia can be used. The diagnostic approach is the same as for pancytopenia. Iatrogenic causes of pancytopenia include chemotherapy for malignancies if the drug or drugs used cause bone marrow suppression. Rarely, drugs (antibiotics, blood pressure medication, heart medication) can cause pancytopenia. The antibiotics Linezolid and Chloramphenicol can cause pancytopenia in some individuals. Rarely, pancytopenia may have other causes, such as mononucleosis, or other viral diseases. Increasingly, HIV is itself a cause for pancytopenia. Familial hemophagocytic syndrome Aplastic anemia Gauchers disease metastatic carcinoma of bone Multiple Myeloma overwhelming infections Lymphoma myelofibrosis Dyskeratosis congenita Myelodysplastic syndrome Leukemia Leishmaniasis Severe Folate or vitamin B12 ...
Red cell distribution width (RDW) and the neutrophil/lymphocyte ratio (NLR) are predictors of cardiovascular risk that have been shown to correlate with impaired reperfusion and increased morbidity and mortality in patients with an ST-segment elevati
and monitored for changes in the blood profile using a haematological analyser. A chronic infection lasting between 48 and 112 days was observed. Microcytic hypochromic anaemia, which was characterized by a decline in packed cell volume (PCV), red blood cell (RBC) numbers, mean corpuscular volume (MCV) and mean corpuscular haemoglobin concentration (MCH) developed at an early stage, and persisted throughout the infection. The mean platelet counts declined significantly from 3 x 105/μl (day 0 post infection) to 6.8 x 104/μl (day 7 post infection) and remained low in all the animals. However, the mean platelets volume rose during the course of the infection. An initial decline in total white blood cell (WBC) counts occurred between day 0 and 7 (3.1 x 106/μl) and remained low up to day 35 post infection (3.5 x 106/μl). This was followed by an increase in WBC counts, principally associated with increased lymphocyte numbers. It is concluded that microcytic hypochromic anaemia, thrombocytopaenia ...
Tick-borne diseases can directly or indirectly affect haematological parameters. It is thus imperative that any animal that has a haematological abnormality be screened for possible underlying parasitic infection. Tick-borne organisms that can result in haematological changes include the rickettsias, mycoplasma, bacteria, and protozoa. As there are no specific haematological changes with tick-borne viral encephalitis and Lyme borreliosis, they will not be discussed further in this paper.. Rocky mountain spotted fever. Rocky Mountain Spotted Fever is caused by Rickettsia rickettsii, an obligate intracellular bacterial organism. The organism is transmitted by Dermacentor variabilis, D. andersoni, Rhipicephalus sanguineus, and Amblyomma cajennense. Within the body the organism invades and replicates in the endothelial cells of small arteries and venules, resulting in a necrotic vasculitis with subsequent activation of platelets and the coagulation system.. Mild-to-moderate normocytic normochromic ...

Low White Blood Cell CountLow White Blood Cell Count

Boosting your white blood cell count. If you have a low white blood cell count, your doctor can prescribe medicines to help ... Things to consider if you have a low white blood cell count. If you have a low white blood cell count, consider taking the ... If you get an infection because you have a low white blood cell count, your symptoms may include:. *fever (call your doctor ... explains different types of white blood cells, how breast cancer treatment lowers their levels, and what low white blood cell ...
more infohttps://www.breastcancer.org/treatment/side_effects/low_white_blood_cell

White Blood Cell Count And Differential | Encyclopedia.comWhite Blood Cell Count And Differential | Encyclopedia.com

Definition A white blood cell (WBC) count determines the concentration of white blood cells in the patients blood. A ... differential determines the percentage of each of the five types of mature white blood cells. ... White Blood Cell Count and Differential. Definition. A white blood cell (WBC) count determines the concentration of white blood ... White blood cell count and differential. Definition. A white blood cell (WBC) count determines the concentration of white blood ...
more infohttps://www.encyclopedia.com/medicine/divisions-diagnostics-and-procedures/medicine/white-blood-cell-count-and-differential

white blood cell count - Everything2.comwhite blood cell count - Everything2.com

A laboratory test performed on a sample of a patients blood. This is a routine blood test. It determines the number of leuk... ... white blood cells. blood count. desmoplaquin. Glioblastoma. immune system. carboplatin. Helping your kid brother die. ... This diluted blood is then put into a counting chamber called a hemocytomer and the white cells are counted. Then the number of ... This is a routine blood test. It determines the number of leukocytes in the blood. Higher than normal counts can indicate the ...
more infohttps://everything2.com/title/white+blood+cell+count

Blood Cell Count | ASPEBlood Cell Count | ASPE

According to the Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it displays a valid OMB control number. The valid OMB control number for this information collection is 0990-0379. The time required to complete this information collection is estimated to average 5 minutes per response, including the time to review instructions, search existing data resources, gather the data needed, and complete and review the information collection. If you have comments concerning the accuracy of the time estimate(s) or suggestions for improving this form, please write to: U.S. Department of Health & Human Services, OS/OCIO/PRA, 200 Independence Ave., S.W., Suite 336-E, Washington D.C. 20201, Attention: PRA Reports Clearance Officer ...
more infohttps://aspe.hhs.gov/document-terms/blood-cell-count

White blood cell count  - series-Indication: MedlinePlus Medical EncyclopediaWhite blood cell count - series-Indication: MedlinePlus Medical Encyclopedia

Count measures two components: the total number of WBCs (leukocytes), and the differential count. The differential count ... The White Blood Cell (WBC) Count measures two components: the total number of WBCs (leukocytes), and the differential count. ... White blood cells are a major component of the bodys immune system. Indications for a WBC count include infectious and ... The differential count measures the percentages of each type of leukocyte present. WBCs are composed of granulocytes ( ...
more infohttps://medlineplus.gov/ency/presentations/100151_1.htm

White blood cell count  - series-Results: MedlinePlus Medical EncyclopediaWhite blood cell count - series-Results: MedlinePlus Medical Encyclopedia

Acute emotional or physical stress can increase WBC counts. There are various types of white blood cells (WBCs) that normally ... WBC - 4,500 to 10,000 cells/mcl. (Note: cells/mcl = cells per microliter). ... This usually entails increased numbers of cells and an increase in the percentage of immature cells (mainly band zcells) in the ... Drugs that may increase WBC counts include epinephrine, allopurinol, aspirin, chloroform, heparin, quinine, corticosteroids, ...
more infohttps://medlineplus.gov/ency/presentations/100151_3.htm

High white blood cell count - Mayo ClinicHigh white blood cell count - Mayo Clinic

Overview covers possible causes of increased disease-fighting cells. ... A high white blood cell count is an increase in disease-fighting cells in your blood. ... for adults a count of more than 11,000 white blood cells (leukocytes) in a microliter of blood is considered a high white blood ... The exact threshold for a high white blood cell count varies from one laboratory to another. In general, ...
more infohttps://www.mayoclinic.org/symptoms/high-white-blood-cell-count/basics/definition/sym-20050611

Low red blood cell count: Symptoms, diet, and lifestyle changesLow red blood cell count: Symptoms, diet, and lifestyle changes

People can increase their red blood cell count through simple lifestyle changes, such as exercising, limiting alcohol, and ... A low red blood cell count, or anemia, can cause many symptoms and complications, including fatigue and weakness. ... Understanding blood count. Normal red blood cell counts vary from around 4.7 to 6.1 million cells per microliter (µL) for men ... Red blood cells are the most abundant cells in human blood. The cells contain hemoglobin, which is a protein that carries ...
more infohttps://www.medicalnewstoday.com/articles/319457.php?sr

High White Blood Cell Count - Respiratory Disorders - MedHelpHigh White Blood Cell Count - Respiratory Disorders - MedHelp

I have been going to a specialist for thyroid disorder and was told after blood work was done that my white blood cell count ... Not sure what a white blood cell count of 22 means but it is probably short-hand for a count of 22,000. Equally as important ... I have been going to a specialist for thyroid disorder and was told after blood work was done that my white blood cell count ... I had a blood count reading of this sort a couple of years ago and havent though much about it since. My doc wants to wait a ...
more infohttp://www.medhelp.org/posts/Respiratory-Disorders/High-White-Blood-Cell-Count/show/537851

Low white blood cell count - Canadian Cancer SocietyLow white blood cell count - Canadian Cancer Society

Learn about managing a low white blood cell count. ... A low white blood cell count increases the risk of infection ... Low white blood cell count. Neutropenia and leukopenia are terms used to refer to lowered numbers of white blood cells (WBCs) ... Once the WBC count drops, it remains low for 7-10 days. The lowest level that blood cell counts reach is called the nadir. ... People with cancer usually find out they have low white blood cell counts from a blood test or when they get an infection. An ...
more infohttp://www.cancer.ca/en/cancer-information/diagnosis-and-treatment/managing-side-effects/low-white-blood-cell-count/?region=qc

High white blood cell count - Leukemia & Lymphoma  - MedHelpHigh white blood cell count - Leukemia & Lymphoma - MedHelp

... but in the past few years I have had a few blood tests and each time they say I have a high white bloo... ... but in the past few years I have had a few blood tests and each time they say I have a high white blood cell count. I know that ... but in the past few years I have had a few blood tests and each time they say I have a high white blood cell count. I know that ... High white blood cell count. I am 16 years old and just wondering (I did not want to make a doctors appointment just for this ...
more infohttp://www.medhelp.org/posts/Leukemia--Lymphoma-/High-white-blood-cell-count/show/366608

Blood Cell Counts -- TheBody.comBlood Cell Counts -- TheBody.com

I need help figuring out my white blood cell count and lymphocyte differential. Jul 27, 2003. ... low CD4 count-med related?. Apr 17, 2004. Twice, huge differences between labs/T cells and Abs Lymphs a week apart. Apr 11, ... Complete Blood Count (CBC) Fact Sheet Browse Forums: <-- Select . Aging. Choosing Your Meds. En Espa ol. In Italiano. Facial ... Following up my Question about Neutrophils and Lymphocyetes blood cells with more details. Jun 20, 2015. ...
more infohttp://www.thebody.com/Forums/AIDS/Labs/Archive/BloodCell/index.html

Red Blood Cell Count (RBC): Purpose, Procedure, and PreparationRed Blood Cell Count (RBC): Purpose, Procedure, and Preparation

The test is usually part of a complete blood count (CBC) test that measures all the components in your blood. Well explain why ... An RBC count is a blood test thats used to find out how many red blood cells (RBCs) you have. ... What is a red blood cell count?. A red blood cell count is a blood test that your doctor uses to find out how many red blood ... How to Increase Your Red Blood Cell Count. Has your doctor advised you to increase your red blood cell count? These supplements ...
more infohttps://www.healthline.com/health/rbc-count

white blood cell count (thing) by skybluefusion - Everything2.comwhite blood cell count (thing) by skybluefusion - Everything2.com

A laboratory test performed on a sample of a patients blood. This is a routine blood test. It determines the number of leuk... ... white blood cell count (thing). See all of white blood cell count, no other writeups in this node. ... white blood cells. blood count. desmoplaquin. Glioblastoma. immune system. carboplatin. Helping your kid brother die. ... This diluted blood is then put into a counting chamber called a hemocytomer and the white cells are counted. Then the number of ...
more infohttps://everything2.com/user/skybluefusion/writeups/white+blood+cell+count

What Causes Low White Blood Cell Count? | Reference.comWhat Causes Low White Blood Cell Count? | Reference.com

A low white blood cell count, called leukopenia, may be caused by bone marrow problems, autoimmune disorders such as lupus, ... A low white blood cell count is defined as less than 4,500 white blood cells per microliter of blood, or less than 1,700 ... Neutrophils are a specific type of white blood cell that help fight infections. A normal white blood cell count ranges from ... A low white blood cell count, called leukopenia, may be caused by bone marrow problems, autoimmune disorders such as lupus, ...
more infohttps://www.reference.com/world-view/causes-low-white-blood-cell-count-b6b2a4fb7df18a4a

005033: Red Blood Cell (RBC) Count | LabCorp005033: Red Blood Cell (RBC) Count | LabCorp

Decrease in RBC count may be the result of red cell loss by bleeding or hemolysis (intravascular or extravascular), failure of ... Hemolysis; clotted specimen; tube not filled with minimum volume; improper labeling; transport tubes with whole blood; specimen ... Increase in RBC count may be the result of primary polycythemia (polycythemia vera) or secondary polycythemia (hypoxemia of ... lung or cardiovascular disease, increased erythropoietin production associated with renal cyst, renal cell carcinoma, ...
more infohttps://www.labcorp.com/test-menu/34236/red-blood-cell-rbc-count

Low Red Blood Cell Count in DogsLow Red Blood Cell Count in Dogs

A low red blood cell count can be indicative of a medical condition. The red blood cell count is measured when a complete blood ... Causes of Low Red Blood Cell Count. In dogs, the low red blood cell count may be caused by:. *Anemia, which is due to decreased ... Low Red Blood Count Treatment Options. The treatment for a pet with low red blood cell count will depend on the findings of the ... The red blood cells carry the oxygen to the tissues. If the red blood count is extremely low, the dog may be lethargic and have ...
more infohttps://www.vetinfo.com/low-red-blood-cell-count-in-dogs.html

Low blood cell counts - Canadian Cancer SocietyLow blood cell counts - Canadian Cancer Society

... blood cells are not replaced as they normally would be and blood cell counts drop. Blood cell counts usually start to drop 7-10 ... Symptoms of low blood cell counts are often worse at nadir. Blood cell counts often begin to recover and rise on their own, ... Managing low blood cell counts. Once the cause of low blood cell counts is known, your healthcare team can develop a treatment ... A low blood cell count is managed based on the type of blood cell affected. Some people need medicines or blood transfusions to ...
more infohttps://www.cancer.ca/en/cancer-information/diagnosis-and-treatment/managing-side-effects/low-blood-cell-counts/?region=ab

White blood cell count - Medical Dictionary / Glossary | MedindiaWhite blood cell count - Medical Dictionary / Glossary | Medindia

White blood cell count - Number of infection-fighting cells in a unit (conventionally 1 litre) of blood, is clearly explained ... Medical Word - White blood cell count. Ans : Number of infection-fighting cells in a unit (conventionally 1 litre) of blood. ... White blood cell count - Glossary. Written & Compiled by Medindia Content Team. Medically Reviewed by The Medindia Medical ... Beetroot tea is a healthy beverage, which is extremely beneficial for high blood pressure, ... ...
more infohttps://www.medindia.net/glossary/white_blood_cell_count.htm

Signs & symptoms of low monocytes blood cell countSigns & symptoms of low monocytes blood cell count

Their specific role is to destroy infectious organisms that invade the body and cancer cells. ... Monocytes are a type of white blood cell produced by the bone marrow. ... signs-monocytes-blood-cell-count.html Larson, Colette. "Signs & symptoms of low monocytes blood cell count" last modified May ... A low monocyte blood cell count diagnosis is based on the results of a complete blood count from a sample removed from the ...
more infohttp://www.ehow.co.uk/about_5606257_signs-monocytes-blood-cell-count.html

Low white blood cell count - HealthBoards Message BoardsLow white blood cell count - HealthBoards Message Boards

Low white blood cell count. [ Back to Messages ] Message. Posted by Cindy on December 16, 2000 at 03:24:10:. In Reply to: Re: ... Low white blood cell count posted by Margaret Christensen on July 31, 2000 at 15:34:01:. i have just been told that i have a ... virus that is reducing my white blood cells.. do you have any information on this topic?. Follow Ups. ...
more infohttps://www.healthboards.com/hepatitis/1591.html

What Does a High Red Blood Cell Count Mean? | Reference.comWhat Does a High Red Blood Cell Count Mean? | Reference.com

An elevated red blood cell count is associated with dehydration, congenital heart disease, kidney tumors, bone marrow diseases ... What Is the Normal Level for Red Blood Count in Urine?. A: A normal red blood cell count in a urine test is 4 red blood cells ... What Is the Normal Range for a Red Blood Cell Count?. A: A normal red blood cell count ranges from 4.7 to 6.1 million cells per ... What Is Considered a Low Red Blood Cell Count?. A: A normal red blood cell count for males is 4.7 to 6.1 million cells per ...
more infohttps://www.reference.com/health/high-red-blood-cell-count-mean-3a50868f74809f2e

Top treatments for Low red blood cell count | PatientsLikeMeTop treatments for Low red blood cell count | PatientsLikeMe

See how others experience low red blood cell count. Join the community to connect with others like you and learn about their ...
more infohttps://www.patientslikeme.com/symptoms/low-red-blood-cell-count

I have a low white blood cell count. What does it mean?I have a low white blood cell count. What does it mean?

... I suggest at this stage you take echinacea - a herbal product - that ... My doctor has told me I have a low white blood cell count. ... Platelet count after glandular fever. The term OSI in a blood ... and the reason for my infections could be due to low white blood cell count. ... The white cell count is sometimes lower after viral infections - flu and glandular fever in particular. It is not a cause for ...
more infohttps://www.netdoctor.co.uk/ask-the-expert/cardiovascular/a944/i-have-a-low-white-blood-cell-count-what-does-it-mean/
  • The WBC count provides clues about certain illnesses, and helps physicians monitor a patient's recovery from others. (encyclopedia.com)
  • A laboratory test performed on a sample of a patient's blood . (everything2.com)
  • A low monocyte blood cell count diagnosis is based on the results of a complete blood count from a sample removed from the patient's vein. (ehow.co.uk)
  • The approach proved 95 percent accurate for determining whether a patient's white cell levels were above or below the threshold.To obtain enough data to make these classifications, the researchers recorded one minute of video per patient. (medindia.net)
  • Increase in RBC count may be the result of primary polycythemia (polycythemia vera) or secondary polycythemia (hypoxemia of lung or cardiovascular disease, increased erythropoietin production associated with renal cyst, renal cell carcinoma, cerebellar hemangioblastoma, or high O 2 affinity hemoglobinopathy) including stress polycythemia (hemoconcentration associated with exercise, exertion, fright, etc). (labcorp.com)
  • This usually entails increased numbers of cells and an increase in the percentage of immature cells (mainly band zcells) in the blood. (medlineplus.gov)
  • For example, an elevated WBC count with an absolute increase in lymphocytes having an atypical appearance is most often caused by infectious mononucleosis . (encyclopedia.com)
  • According to the American Association for Clinical Chemistry (AACC) , the test is almost always a part of a complete blood count (CBC) test. (healthline.com)
  • American Association for Clinical Chemistry: "Complete Blood Count," "Reference Ranges and What They Mean. (webmd.com)
  • Conversely, hypokalemia or low blood potassium is characterized by symptoms such as cramping muscles, digestive problems and general weakness. (livestrong.com)
  • Plasma cells make antibodies against infectious agents such as viruses and bacteria. (myeloma.org)